Abstract:
Disclosed are chromene-2 derivatives and the use thereof in the treatment of fibrosis. Specifically, disclosed are the derivatives of a compound having a main structure of 6,7-dimethoxy-chromenylium perchlorate (1) and pharmaceutical compositions, combinations and pharmaceutically suitable salts thereof for the treatment of fibrosis.

Description:
FIELD OF THE INVENTION 
       [0001]    The present invention is related to chromene-2 derivatives and use thereof in the treatment of fibrosis. The invention is related to the derivatives of a compound having a main structure of 6,7-dimethoxy-chromenylium perchlorate (1) and pharmaceutical compositions, combinations and pharmaceutically suitable salts thereof for the treatment of fibrosis. 
         [0002]    The R1 and R2 positions are selected as main replacement positions and these points are combined with hydroxyl (—OH), methyl (—CH3), ethyl (—C2H5) and combinations thereof. 
         [0003]    The compounds of this invention have the ability to affect the TGF□ signal transduction pathways for synthesis of collagen, elastin, fibronectin, COMP (Cartilage Oligomeric Protein). Osteopontin etc, and inhibit epithelial mesenchimal cell transition. Thus, said compounds can be effectively used in the treatment of idiopathic pulmonary fibrosis-IPF, Chronic Obstructive Pulmonary Disease (COPD), sarcoidosis, kidney fibrosis, heart fibrosis, atherosclerosis, pancreatic fibrosis, pancreatitis, liver fibrosis and cirrhosis, non-alcoholic steatohepatitis-NASH) and alcoholic siteatohepatitis 
         [0004]    Lung fibrosis is a disease with an unknown etiology. Although multiple factors have been blamed for development of IPF actual cause for development of IPF is unknown. Since its cause is unknown it is named as idiopathic lung fibrosis. IPF is commonly accepted as a disease of elderly, and its prevalence is 20/100,000 for men and 13/100,000 for women. Currently, it is estimated that 5 million people are affected from this disease worldwide (Eric B Meltzer and Paul W Noble Idiopathic pulmonary fibrosis.  Orphanet Journal of Rare Diseases  2008, 3:8:1-15). It is commonly accepted that growth factors and cytokine, which are secreted by macrophages accumulate in the lung as a response to inflammation, play significant role in development of IPF (Todd N W, Scheraga R G, Galvin J R, Iacono A T, Britt E J, Luzina I G, et al. Lymphocyte aggregates persist and accumulate in the lungs of patients with idiopathic pulmonary fibrosis. J Inflamm Res 2013; 6: 63-70.) Cytokines IL4, IL13 and TGF□ secreted by macrophages initiates EMT process and during which alveolar epithelia cells turn mesenchima fibroblasts, (Kim K K, Kugler M C, Wolters P J, Robillard L, Galvez M G, Brumwell A N. et al. Alveolar epithelial cell mesenchymal transition develops in vivo during pulmonary fibrosis and is regulated by the extracellular matrix. Proc Natl Acad Sci USA 2006; 103: 13180-1318. Konigshoff M. Lung cancer in pulmonary fibrosis: tales of epithelial cell plasticity. Respiration 2011; 81: 353-358). Among the secreted cytokines TGFb induces expression and deposition of collagen from alveolar epithelial cells. (Broekelmann T J, Limper A H, Colby T V, McDonald J A. Transforming growth factor beta 1 is present at sites of extracellular matrix gene expression in human pulmonary fibrosis.  Proc Natl Acad Sci USA  1991:88:6642-6646. Khalil N, O&#39;Connor R N, Flanders K C, Unruh H. TGF-b1, but not TGF-b2 or TGF-b3, is differentially present in epithelial cells of advanced pulmonary fibrosis: an immunohistochemical study.  Am J Respir Cell Mol Biol  1996; 14:131-138). Structural proteins deposited at extracellular matrix reduces the size of alveolar space, limits diffusion of oxygen and make breathing impossible. (Zhang K, Rekhter M D, Gordon D, Phan S H, Myofibroblasts and their role in lung collagen gene expression during pulmonary fibrosis: a combined immunohistochemical and in situ hybridization study.  Am J Pathol  1994; 145:114-125. Turner-Warwick M, Burrows B, Johnson A: Cryptogenic fibrosing alveolitis: clinical features and their influence on survival.  Thorax  1980, 35(3):171-180. Agusti A G, Roca J, Gea J, Wagner P D, Xaubet A, Rodriguez-Roisin R: Mechanisms of gas-exchange impairment in idiopathic pulmonary fibrosis.  Am Rev Respir Dis  1991, 143(2):219-225). Uncontrolled growth of lung cells and deposition of matrix proteins perturbs the structure of lung which can be visulized by computerised tomography (CT). According to the results obtained from CT scans, one of the hallmark of lung fibrosis is the formation of “honey comb” structures, and this is “gold standard” in defining this disease. (Parambil J G, Myers J L, Ryu J H: Histopathologic features and outcome of patients with acute exacerbation of idiopathic pulmonary fibrosis undergoing surgical lung biopsy.  Chest  2005, 128(5):3310-3315. Akira M, Hamada H, Sakatani M, Kobayashi C, Nishioka M. Yamamoto S: CT findings during phase of accelerated deterioration in patients with idiopathic pulmonary fibrosis.  AJR Am J Roentgenol  1997, 168(1):79-83). Since lung fibrosis was initially thought to develop as a result of inflammation it was treated with anti-inflammatory compounds such as prednisol, n-acetyl cystein, cyclophosphamide, and cortisol. However, none of these treatment options produced significant survival benefit for IPF patients. (Collard H R, Ryu J H, Douglas W W, Schwarz M I, Curran-Everett D. King T E Jr., Brown K K: Combined corticosteroid and cyclophosphamide therapy does not alter survival in idiopathic pulmonary fibrosis.  Chest  2004, 125(6):2169-2174. Behr J, Maier K, Degenkolb B. Krombach F, Vogelmeier C: Antioxidative and clinical effects of high-dose N-acetylcysteine in fibrosing alveolitis. Adjunctive therapy to maintenance immunosuppression.  Am J Respir Crit Care Med  1997, 156(6):1897-1901. Zisman D A, Lynch J P 3rd, Toews G B, Kazerooni E A, Flint A, Martinez F J: Cyclophosphamide in the treatment of idiopathic pulmonary fibrosis: a prospective study in patients who failed to respond to corticosteroids.  Chest  2000, 117(6):1619-1626). At the beginning of 2000, small molecule named “Pirfenidone” was tested against IPF in USA and Japan. In 2008, a japanese company Shinogi completed a successful phase III study and got approval for the use Pirfenidone to treat IPF patients in Japan. (Azuma A, Nukiwa T, Tsuboi E. et al. Double-blind, placebo-controlled, trial of pirfenidone in patients with idiopathic pulmonary fibrosis. Am J Respir Crit Care Med 2005; 171:1040-1047). In addition to this, US company called InterMune conducted 3 independent phase 3 studies and showed the efficacy of this compound against IPF and got FDA approval in October of 2014, and began marketing Pirfenidone under the brand name Esbriest. Also, in October 2014, another novel drug “Nintedanib” produced by Boehringer Ingelheim (BI) got approval for IPF (Jason Potts, Dinesh Yogaratnam. Pirfenidone: A Novel Agent for the Treatment of Idiopathic Pulmonary Fibrosis  The Annals of Pharmacotherapy  n 2013 March, Volume 47 361-367, and InterMune and BI Web sites). 
         [0005]    Currently, the only treatment options for IPF are Pirfeinidone and Nintedanib and both drugs have limited efficacy. One of the main reasons for having difficulty to treat this disease is the fact that factor(s) causing the development of this disease are not fully understood. For this very reason, we believe that there is still need for development of new drug candidates to effective treatment of IPF. 
         [0006]    In this respect, there are some patents or patent applications claiming the use of Chromene derivatives as an alternative treatment options. Some of these are shown below; 
         [0000]    
       
                 
         
             
             
         
       
     
         [0007]    EP2295053A1 discloses Chromene and some of its derivatives generated by changing R1 and R2 have been claimed for treatment of fibrosis. 
         [0000]    
       
                 
         
             
             
         
       
     
         [0008]    U.S. Pat. No. 8,048,912,B2 discloses the compound created from Chromene has been claimed to be used against fibrosis caused by TGF-beta. 
         [0000]    
       
                 
         
             
             
         
       
     
         [0009]    US 2009/0088477 A1 discloses the main structure shown below and its derivatives have been claimed to be used against asthma, COPD and atherosclerosis. 
         [0000]    
       
                 
         
             
             
         
       
     
         [0010]    WO 2006 070984 discloses the main structure shown below and its derivatives have been claimed to be used against diseases which derive from collagen deposition. 
         [0000]    
       
                 
         
             
             
         
       
     
         [0011]    US 2012/0196867 A1 discloses the main structure shown below and its has been claimed to be used against COPD as phosphodiesterase inhibitor. 
         [0000]    
       
                 
         
             
             
         
       
     
         [0012]    EP2620443A1 discloses the main structure shown below and its derivatives have been claimed to be used against fibrosis as Galectin-3 inhibitor. 
         [0000]    
       
                 
         
             
             
         
       
     
         [0013]    WO2006070984A1 discloses the main structure shown below and its derivatives have been claimed to be used against fibroplasias and TGF-induced fibrosis. 
         [0000]    
       
                 
         
             
             
         
       
     
       OBJECT OF THE INVENTION 
       [0014]    Although derivatives of 6,7-dimethoxy 2H-chromen-2-one (1) have been claimed to be used as anti-fibrotic agent, currently there is no chromene-derived anti-fibrotic drugs. In the present invention, carbonyl oxygen is removed from Chromene structure, this yielded positively charged chromene, then from this structure, 72 different molecules composed of 8 different molecule (4,5,6,7,8,9,10,11) with 9 different combinations were generated. 
     
    
     
       DESCRIPTION OF THE DRAWINGS 
         [0015]      FIG. 1 : Inhibitor effect of 6,7-dimethoxy 2H-chromen-one (1) on TGFbeta-induced collagen synthesis in L929 cells. 
           [0016]      FIG. 2 : Inhibitor effect of 6,7-dimethoxy 2H-chromen-one (1) on proliferation of L929 cells. 
           [0017]      FIG. 3 : Inhibitor effect of 6,7-dimethoxy 2H-chromen-one (1) on TGFbeta-induced secreted collagen synthesis in L929 cells 
           [0018]      FIG. 4 : 6,7-dimethoxy-2H-chromen-2-one 
           [0019]      FIG. 5 : Main compound produced from 6,7-dimethoxy-2H-chromen-2-one 
           [0020]      FIG. 6 : Side chain added to the compound described at  FIG. 5 , 
           [0021]      FIG. 7 : First structure produced from  FIG. 5 . 
           [0022]      FIG. 8 : 6,7-dimethoxy-chromenylium perchlorate. 
           [0023]      FIG. 9 : 6-ethoxy-7 methoxy 2,3,4,5,8-pentamethyl naphatehalen-1-ylium 
           [0024]      FIG. 10 : 7-ethoxy-6-methoxy-2,3,4,5,8-pentamethyl naphatehalen-1-ylium. 
           [0025]      FIG. 11 : 6,7-diethoxy-2,3,4,5,8-pentamethyl naphatehalen-1-ylium. 
           [0026]      FIG. 12 : 6-hydroperoxy-7-methoxy-2,3,4,5,8-pentamethylnaphatehalen-1-ylium 
           [0027]      FIG. 13 : 7-hydroperoxy-6-methoxy-2,3,4,5,8-pentamethylnaphatehalen-1-ylium 
           [0028]      FIG. 14 : 6,7-dihydroperoxy-2,3,4,5,8-pentamethylnaphatehalen-1-ylium 
           [0029]      FIG. 15 : 7-ethoxy-6-hydroperoxy-2,3,4,5,8-pentamethylnaphatehalen-1-ylium 
           [0030]      FIG. 16 : 6-ethoxy-7-hydroperoxy-2,3,4,5,8-pentamethylnaphatehalen-1-ylium 
           [0031]      FIG. 17 : Second structure produced from  FIG. 5 . 
           [0032]      FIG. 18 : 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6,7-dimethoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-(1:1) formaldehyde compound 
           [0033]      FIG. 19 : 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6-ethoxy-7-methoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-(1:1) formaldehyde compound 
           [0034]      FIG. 20 : 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-7-ethoxy-6-methoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-(1:1) formaldehyde compound 
           [0035]      FIG. 21 : 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6,7-diethoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-(1:1) formaldehyde compound 
           [0036]      FIG. 22 : 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6-hydroperoxy-7-methoxy-3,4,5,8-tetramethyl-1λ 3 -chromen (1:1) formaldehyde compound  FIG. 23 : 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-7-hydroperoxy-6-methoxy-3,4,5,8-tetramethyl-1λ 3 -chromen (1:1) formaldehyde compound  FIG. 24 : 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6,7-dihydroperoxy-3,4,5,8-tetramethyl-1λ 3 -chromen (1:1) formaldehyde compound 
           [0037]      FIG. 25 : 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-7-ethoxy-6-hydroperoxy-3,4,5,8-tetramethyl-1λ 3 -chromen (1:1) formaldehyde compound 
           [0038]      FIG. 26 : 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6-ethoxy-7-hydroperoxy-3,4,5,8-tetramethyl-1λ 3 -chromen (1:1) formaldehyde compound 
           [0039]      FIG. 27 : 3th structure produced from  FIG. 5 . 
           [0040]      FIG. 28 : 7-ethoxy-6methoxy-2,3,4,5,8-pentamethylnaphthalen-1-ylium 
           [0041]      FIG. 29 : 6,7-diethoxy-2,3,4,5,8-pentamethyl naphatehalen-1-ylium 
           [0042]      FIG. 30 : 6-methoxy-2,3,4,5,8-pentamethyl-7-propoxynaphatehalen-1-ylium 
           [0043]      FIG. 31 : 6-ethoxy-2,3,4,5,8-pentamethyl-7-propoxynaphatehalen-1-ylium 
           [0044]      FIG. 32 : 7-ethoxy-6-hydroperoxy-2,3,4,5,8-pentamethyl naphatehalen-1-ylium 
           [0045]      FIG. 33 : 7-(hydroxymethoxy)-6-methoxy-2,3,4,5,8-pentamethyl naphatehalen-1-ylium 
           [0046]      FIG. 34 : 6-hydroperoxy-7-(hydroxymethoxy)-2,3,4,5,8-pentamethyl naphatehalen-1-ylium 
           [0047]      FIG. 35 : 6-hydroperoxy-2,3,4,5,8-pentamethyl-7-propoxynaphatehalen-1-ylium 
           [0048]      FIG. 36 : 6-ethoxy-7-(hydroxymethoxy)-2,3,4,5,8-pentamethylnaphatehalen-1-ylium 
           [0049]      FIG. 37 : 4th structure produced from  FIG. 5 . 
           [0050]      FIG. 38 : 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-7-ethoxy-6-methoxy-3,4,5,8-tetramethyl-1λ 3 -chromen and methyl-λ 1 -oxidane (4:1:1) formaldehyde compound 
           [0051]      FIG. 39 : 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6,7-diethoxy-3,4,5,8-tetramethyl-1λ 3 -chromen and methyl-λ 1 -oxidane (3:1:1) formaldehyde compound 
           [0052]      FIG. 40 : 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6-methoxy-3,4,5,8-tetramethyl-7-propoxy-1λ 3 -chromen and methyl-λ 1 -oxidane (3:1:1) formaldehyde compound 
           [0053]      FIG. 41 : 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6-ethoxy-3,4,5,8-tetramethyl-7-propoxy-1λ 3 -chromen and methyl-λ 1 -oxidane (3:1:1) formaldehyde compound 
           [0054]      FIG. 42 : 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-7-ethoxy-6-hydroperoxy-3,4,5,8-tetramethyl-1λ 3 -chromen and methyl-λ 1 -oxidane (3:1:1) formaldehyde compound 
           [0055]      FIG. 43 : 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6-methoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-7-yl)oxy)methanol and methyl-λ 1 -oxidane (3:1:1) formaldehyde compound 
           [0056]      FIG. 44 : 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6-hydroperoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-7-yl)oxy)methanol and methyl-λ 1 -oxidane (3:1:1) formaldehyde compound 
           [0057]      FIG. 45 : 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6-hydroperoxy-3,4,5,8-tetramethyl-7-propoxy-1λ 3 -chromen and methyl λ 1 -oxidane (3:1:1) formaldehyde compound 
           [0058]      FIG. 46 : 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6-ethoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-7-yl)oxy)methanol and methyl-λ 1 -oxidane (3:1:1) formaldehyde compound 
           [0059]      FIG. 47 : 5th structure produced from  FIG. 5 . 
           [0060]      FIG. 48 : 6-ethoxy 7-methoxy-2,3,4,5,8-pentamethylnaphatehalen-1-ylium 
           [0061]      FIG. 49 : 7-methoxy-2,3,4,5,8-pentamethyl-6-propoxynaphatehalen-1-ylium 
           [0062]      FIG. 50 : 6,7-diethoxy-2,3,4,5,8-pentamethylnaphatehalen-1-ylium 
           [0063]      FIG. 51 : 7-ethoxy-2,3,4,5,8-pentamethyl-6-propoxynaphatehalen-1-ylium 
           [0064]      FIG. 52 : 6-(hydroxymethoxy)-7-methoxy-2,3,4,5,8-pentamethylnaphatehalen-1-ylium 
           [0065]      FIG. 53 : 6-ethoxy-7-hydroperoxy-2,3,4,5,8-pentamethylnaphatehalen-1-ylium 
           [0066]      FIG. 54 : 7-hydroperoxy-6-(hydroxymethoxy)-2,3,4,5,8-pentamethylnaphatehalen-1-ylium 
           [0067]      FIG. 55 : 7-ethoxy-6-(hydroxymethoxy)-2,3,4,5,8-pentamethylnaphatehalen-1-ylium 
           [0068]      FIG. 56 : 7-hydroperoxy-2,3,4,5,8-pentamethyl-6-propoxynaphatehalen-1-ylium 
           [0069]      FIG. 57 : 6th structure produced from  FIG. 5 . 
           [0070]      FIG. 58 : 1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(6-ethoxy-7-methoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-2-yl)butan-1-one and methyl λ 1 -oxidane (3:1:1) formaldehyde compound 
           [0071]      FIG. 59 : 3-(6,7-diethoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-2-yl)-1-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-1-one-and methyl-λ 1 -oxidane (3:1:1) formaldehyde compound 
           [0072]      FIG. 60 : 1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(7-methoxy-3,4,5,8-tetramethyl-6-propoxy-1λ 3 -chromen-2-yl)butan-1 I-one and methyl λ 1 -oxidane (3:1:1) formaldehyde compound 
           [0073]      FIG. 61 : 1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(7-ethoxy-3,4,5,8-tetramethyl-6-propoxy-1λ 3 -chromen-2-yl)butan-1-one and methyl λ 1 -oxidane (3:1:1) formaldehyde compound 
           [0074]      FIG. 62 : 1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(6-(hydroxymethoxy)-7-methoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-2-yl)butan-1-one and methyl λ 1 -oxidane (3:1:1) formaldehyde compound 
           [0075]      FIG. 63 : 1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(6-ethoxy-7-hydroperoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-2-yl)butan-1-one-and methyl-λ 1 -oxidane (3:1:1) formaldehyde compound 
           [0076]      FIG. 64 : 1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(7-hydroperoxy-6-(hydroxyperoxy)-3,4,5,8-tetramethyl-1λ 3 -chromen-2-yl)butan-1-one and methyl λ 1 -oxidane (3:1:1) formaldehyde compound 
           [0077]      FIG. 65 : 1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(7-ethoxy-6-(hydroxyperoxy)-3,4,5,8-tetramethyl-1λ 3 -chromen-2-yl)butan-1-one and methyl λ 1 -oxidane (3:1:1) formaldehyde compound 
           [0078]      FIG. 66 : 1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(7-hydroperoxy-3,4,5,8-tetramethyl-6-propoxy-1λ 3 -chromen-2-yl)butan-1-one and methyl λ 1 -oxidane (3:1:1) formaldehyde compound 
           [0079]      FIG. 67 : 7th structure produced from  FIG. 5 . 
           [0080]      FIG. 68 : 6,7-diethoxy-2,3,4,5,8-pentamethylnaphatehalen-1-ylium 
           [0081]      FIG. 69 : 7-ethoxy-2,3,4,5,8-pentamethyl-6-propoxynaphatehalen-1-ylium 
           [0082]      FIG. 70 : 6-ethoxy-2,3,4,5,8-pentamethyl-7-propoxynaphatehalen-1-ylium 
           [0083]      FIG. 71 : 2,3,4,5,8-pentamethyl-6,7-dipropoxynaphatehalen-1-ylium 
           [0084]      FIG. 72 : 7-ethoxy-6-(hydroxymethoxy)-2,3,4,5,8-pentamethylnaphatehalen-1-ylium 
           [0085]      FIG. 73 : 6-ethoxy-7-(hydroxymethoxy)-2,3,4,5,8-pentamethylnaphatehalen-1-ylium 
           [0086]      FIG. 74 : 6,7-bis(hydroxymethoxy)-2,3,4,5,8-pentamethynaphatehalen-1-ylium 
           [0087]      FIG. 75 : 6-(hydroxymethoxy)-2,3,4,5,8-pentamethyl-7-propoxynaphatehalen-1-ylium 
           [0088]      FIG. 76 : 7-(hydroxymethoxy)-2,3,4,5,8-pentamethyl-6-propoxynaphatehalen-1-ylium 
           [0089]      FIG. 77 : 8th structure produced from  FIG. 5 . 
           [0090]      FIG. 78 : 3-(6,7-diethoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-2-yl)-1-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-1-one-and methyl-λ 1 -oxidane (3:1:1) formaldehyde compound 
           [0091]      FIG. 79 : 1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(7-ethoxy,3,4,5,8-tetramethyl-6-propoxy-1λ 3 -chromen-2-yl)butan-1-one-methyl-λ 1 -oxidane(3:1:1) formaldehyde compound 
           [0092]      FIG. 80 : 1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(6-ethoxy-3,4,5,8-tetramethyl-7-propoxy-1λ 3 -chromen-2-yl)butan-1-one-methyl-λ 1 -oxidane(3:1:1) formaldehyde compound 
           [0093]      FIG. 81 : 1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(3,4,5,8-tetramethyl-6,7-dipropoxy-1λ 3 -chromen-2-yl)butan-1-one-methyl-λ 1 -oxidane(3:1:1) formaldehyde compound 
           [0094]      FIG. 82 : 1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(7-ethoxy-6-(hydroxyperoxy)-3,4,5,8-tetramethyl-1λ 3 -chromen-2-yl)butan-1-one and methyl λ 1 -oxidane (3:1:1) formaldehyde compound 
           [0095]      FIG. 83 : 1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(6-ethoxy-7-(hydroxymethoxy)-3,4,5,8-tetramethyl-1λ 3 -chromen-2-yl)butan-1-one-and-methyl-λ 1 -oxidane(3:1:1) formaldehyde compound 
           [0096]      FIG. 84 : 3-(6,7-bis(hydroxymethoxy)-3,4,5,8-tetramethyl-1λ 3 -chromen-2-yl)-1-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-1-one-and-methyl-λ 1 -oxidane(3:1:1) formaldehyde compound 
           [0097]      FIG. 85 : 1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(6-(hydroxymethoxy)-(3,4,5,8-tetramethyl-7-propoxy-1λ 3 -chromen-2-yl)butan-1-one-and-methyl-λ 1 -oxidane(3:1:1) formaldehyde compound 
           [0098]      FIG. 86 : 1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(7-(hydroxymethoxy)-(3,4,5,8-tetramethyl-6-propoxy-1λ 3 -chromen-2-yl)butan-1-one-and-methyl-λ 1 -oxidane(3:1:1) formaldehyde compound. 
       
    
    
     EXPLANATION OF REFERENCES OF FIGURES 
       [0000]    
       
         1: 6,7-dimethoxy-2H-chromen-2-one 
         2: Main compound produced from 6,7-dimethoxy-2H-chromen-2-one 
         3: Side chain added to the compound described at  FIG. 5   
         4: First structure produced from  FIG. 5 . 
         4.1: 6,7-dimethoxy-chromenylium perchlorate 
         4.2: 6-ethoxy-7 methoxy 2,3,4,5,8-pentamethyl naphatehalen-1-ylium 
         4.3: 7-ethoxy-6-methoxy-2,3,4,5,8-pentamethyl naphatehalen-1-ylium 
         4.4: 6,7-diethoxy-2,3,4,5,8-pentamethyl naphatehalen-1-ylium 
         4.5: 6-hydroperoxy-7-methoxy-2,3,4,5,8-pentamethylnaphatehalen-1-ylium 
         4.6: 7-hydroperoxy-6-methoxy-2,3,4,5,8-pentamethylnaphatehalen-1-ylium 
         4.7: 6,7-dihydroperoxy-2,3,4,5,8-pentamethylnaphatehalen-1-ylium 
         4.8: 7-ethoxy-6-hydroperoxy-2,3,4,5,8-pentamethylnaphatehalen-1-ylium 
         4.9: 6-ethoxy-7-hydroperoxy-2,3,4,5,8-pentamethylnaphatehalen-1-ylium 
         5: Second structure produced from  FIG. 5 . 
         5.1: 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6,7-dimethoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-(1:1) formaldehyde compound 
         5.2: 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6-ethoxy-7-methoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-(1:1) formaldehyde compound 
         5.3: 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-7-ethoxy-6-methoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-(1:1) formaldehyde compound 5.4: 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6,7-diethoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-(1:1) 
         formaldehyde compound 5.5: 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6-hydroperoxy-7-methoxy-3,4,5,8-tetramethyl-1λ 3 -chromen (1:1) formaldehyde compound 
         5.6: 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-7-hydroperoxy-6-methoxy-3,4,5,8-tetramethyl-1λ 3 -chromen (1:1) formaldehyde compound 
         5.7: 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6,7-dihydroperoxy-3,4,5,8-tetramethyl-1λ 3 -chromen (1:1) formaldehyde compound 
         5.8: 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-7-ethoxy-6-hydroperoxy-3,4,5,8-tetramethyl-1λ 3 -chromen (1:1) formaldehyde compound 
         5.9: 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6-ethoxy-7-hydroperoxy-3,4,5,8-tetramethyl-1λ 3 -chromen (1:1) formaldehyde compound
 
6: 3th structure produced from  FIG. 5 .
 
6.1: 7-ethoxy-6methoxy-2,3,4,5,8-pentamethylnaphthalen-1-ylium
 
6.2: 6,7-diethoxy-2,3,4,5,8-pentamethyl naphatehalen-1-ylium
 
6.3: 6-methoxy-2,3,4,5,8-pentamethyl-7-propoxynaphatehalen-1-ylium
 
6.4: 6-ethoxy-2,3,4,5,8-pentamethyl-7-propoxynaphatehalen-1-ylium
 
6.5: 7-ethoxy-6-hydroperoxy-2,3,4,5,8-pentamethyl naphatehalen-1-ylium
 
6.6: 7-(hydroxymethoxy)-6-methoxy-2,3,4,5,8-pentamethyl naphatehalen-1-ylium
 
6.7: 6-hydroperoxy-7-(hydroxymethoxy)-2,3,4,5,8-pentamethyl naphatehalen-1-ylium
 
6.8: 6-hydroperoxy-2,3,4,5,8-pentamethyl-7-propoxynaphatehalen-1-ylium
 
6.9: 6-ethoxy-7-(hydroxymethoxy)-2,3,4,5,8-pentamethylnaphatehalen-1-ylium
 
7: 4th structure produced from  FIG. 5 
 
7.1: 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-7-ethoxy-6-methoxy-3,4,5,8-tetramethyl-1λ 3 -chromen and methyl-λ 1 -oxidane (4:1:1) formaldehyde compound
 
7.2: 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6,7-diethoxy-3,4,5,8-tetramethyl-1 λ 3 -chromen and methyl-λ 1 -oxidane (3:1:1) formaldehyde compound
 
7.3: 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6-methoxy-3,4,5,8-tetramethyl-7-propoxy-1λ 3 -chromen and methyl-λ 1 -oxidane (3:1:1) formaldehyde compound
 
7.4: 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6-ethoxy-3,4,5,8-tetramethyl-7-propoxy-1λ 3 -chromen and methyl-λ 1 -oxidane (3:1:1) formaldehyde compound
 
         7.5: 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-7-ethoxy-6-hydroperoxy-3,4,5,8-tetramethyl-1λ 3 -chromen and methyl-λ 1 -oxidane (3:1:1) formaldehyde compound 
         7.6: 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6-methoxy-3,4,5,8-tetramethyl-1 λ 3 -chromen-7-yl)oxy)methanol and methyl-λ 1 -oxidane (3:1:1) formaldehyde compound
 
7.7: 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6-hydroperoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-7-yl)oxy)methanol and methyl-λ 1 -oxidane (3:1:1) formaldehyde compound
 
7.8: 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6-hydroperoxy-3,4,5,8-tetramethyl-7-propoxy-1λ 3 -chromen and methyl λ 1 -oxidane (3:1:1) formaldehyde compound
 
7.9: 2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6-ethoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-7-yl)oxy)methanol and methyl-λ 1 -oxidane (3:1:1) formaldehyde compound
 
8: 5th structure produced from  FIG. 5 .
 
8.1: 6-ethoxy 7-methoxy-2,3,4,5,8-pentamethylnaphatehalen-1-ylium
 
8.2: 7-methoxy-2,3,4,5,8-pentamethyl-6-propoxynaphatehalen-1-ylium
 
8.3: 6,7-diethoxy-2,3,4,5,8-pentamethylnaphatehalen-1-ylium
 
8.4: 7-ethoxy-2,3,4,5,8-pentamethyl-6-propoxynaphatehalen-1-ylium
 
8.5: 6-(hydroxymethoxy)-7-methoxy-2,3,4,5,8-pentamethylnaphatehalen-1-ylium
 
8.6: 6-ethoxy-7-hydroperoxy-2,3,4,5,8-pentamethylnaphatehalen-1-ylium
 
8.7: 7-hydroperoxy-6-(hydroxymethoxy)-2,3,4,5,8-pentamethylnaphatehalen-1-ylium
 
8.8: 7-ethoxy-6-(hydroxymethoxy)-2,3,4,5,8-pentamethylnaphatehalen-1-ylium
 
8.9: 7-hydroperoxy-2,3,4,5,8-pentamethyl-6-propoxynaphatehalen-1-ylium
 
9: 6th structure produced from  FIG. 5 .
 
9.1: 1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(6-ethoxy-7-methoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-2-yl)butan-1-one and methyl λ 1 -oxidane (3:1:1) formaldehyde compound
 
9.2: 3-(6,7-diethoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-2-yl)-1-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-1-one-and methyl-λ 1 -oxidane (3:1:1) formaldehyde compound
 
9.3: 1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(7-methoxy-3,4,5,8-tetramethyl-6-propoxy-1λ 3 -chromen-2-yl)butan-1-one and methyl λ 1 -oxidane (3:1:1) formaldehyde compound
 
9.4: 1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(7-ethoxy-3,4,5,8-tetramethyl-6-propoxy-1λ 3 -chromen-2-yl)butan-1-one and methyl λ 1 -oxidane (3:1:1) formaldehyde compound
 
9.5: 1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(6-(hydroxymethoxy)-7-methoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-2-yl)butan-1-one and methyl λ 1 -oxidane (3:1:1) formaldehyde compound
 
9.6: 1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(6-ethoxy-7-hydroperoxy-3,4,5,8-tetramethyl-1 λ 3 -chromen-2-yl)butan-1-one-and methyl-λ 1 -oxidane (3:1:1) formaldehyde compound
 
9.7: 1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(7-hydroperoxy-6-(hydroxyperoxy)-3,4,5,8-tetramethyl-1λ 3 -chromen-2-yl)butan-1-one and methyl-λ 1 -oxidane (3:1:1) formaldehyde compound
 
9.8: 1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(7-ethoxy-6-(hydroxyperoxy)-3,4,5,8-tetramethyl-1λ 3 -chromen-2-yl)butan-1-one and methyl λ 1 -oxidane (3:1:1) formaldehyde compound
 
9.9: 1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(7-hydroperoxy-3,4,5,8-tetramethyl-6-propoxy-1λ 3 -chromen-2-yl)butan-1-one and methyl λ 1 -oxidane (3:1:1) formaldehyde compound
 
10: 7th structure produced from  FIG. 5 .
 
10.1: 6,7-diethoxy-2,3,4,5,8-pentamethylnaphatehalen-1-ylium
 
10.2: 7-ethoxy-2,3,4,5,8-pentamethyl-6-propoxynaphatehalen-1-ylium
 
10.3: 6-ethoxy-2,3,4,5,8-pentamethyl-7-propoxynaphatehalen-1-ylium
 
10.4: 2,3,4,5,8-pentamethyl-6,7-dipropoxynaphatehalen-1-ylium
 
10.3: 7-ethoxy-6-(hydroxymethoxy)-2,3,4,5,8-pentamethylnaphatehalen-1-ylium
 
10.6: 6-ethoxy-7-(hydroxymethoxy)-2,3,4,5,8-pentamethylnaphatehalen-1-ylium
 
10.7: 6,7-bis(hydroxymethoxy)-2,3,4,5,8-pentamethylnaphatehalen-1-ylium
 
10.8: 6-(hydroxymethoxy)-2,3,4,5,8-pentamethyl-7-propoxynaphatehalen-1-ylium
 
10.9: 7-(hydroxymethoxy)-2,3,4,5,8-pentamethyl-6-propoxynaphatehalen-1-ylium
 
11: 8th structure produced from  FIG. 5  11.1: 3-(6,7-diethoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-2-yl)-1-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-1-one-and methyl-λ 1 -oxidane (3:1:1) formaldehyde compound
 
11.2: 1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(7-ethoxy,3,4,5,8-tetramethyl-6-propoxy-1λ 3 -chromen-2-yl)butan-1-one-methyl-λ 1 -oxidane(3:1:1) formaldehyde compound
 
11.3: 1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(6-ethoxy-3,4,5,8-tetramethyl-7-propoxy-1λ 3 -chromen-2-yl)butan-1-one-methyl-λ 1 -oxidane(3:1:1) formaldehyde compound
 
11.4: 1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(0,3,4,5,8-tetramethyl-6,7-dipropoxy-1λ 3 -chromen-2-yl)butan-1-one-methyl-λ 1 -oxidane(3:1:1) formaldehyde compound
 
11.5: 1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(7-ethoxy-6-(hydroxyperoxy)-3,4,5,8-tetramethyl-1λ 3 -chromen-2-yl)butan-1-one and methyl λ 1 -oxidane (3:1:1) formaldehyde compound
 
11.6: 1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(6-ethoxy-7-(hydroxymethoxy)-3,4,5,8-tetramethyl-1λ 3 -chromen-2-yl)butan-1-one-and-methyl-λ 1 -oxidane(3:1:1) formaldehyde compound
 
11.7: 3-(6,7-bis(hydroxymethoxy)-3,4,5,8-tetramethyl-1λ 3 -chromen-2-yl)-1-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-1-one-and-methyl-λ 1 -oxidane(3:1:1) formaldehyde compound
 
11.8: 1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(6-(hydroxymethoxy)-(3,4,5,8-tetramethyl-7-propoxy-1λ 3 -chromen-2-yl)butan-1-one-and-methyl-λ 1 -oxidane(3:1:1) formaldehyde compound
 
11.9: 1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(7-(hydroxymethoxy)-(3,4,5,8-tetramethyl-6-propoxy-1λ 3 -chromen-2-yl)butan-1-one-and-methyl-λ 1 -oxidane(3:1:1) formaldehyde compound
 
       
     
       DESCRIPTION OF THE INVENTION 
       [0123]    The present invention is about novel compounds which may offer alternative treatment options against IPF, which believed to develop as a consequences of smoking, pollution, allergens, toxins and seen in people who are older than 50 years old. The compounds mentioned in this application have been generated from “6,7-dimethoxy 2H-chromen-one (1), which was identified from local medicinal plants during our screening studies. The anti-fibrotic activity of this compound (“6,7-dimethoxy 2H-chromen-one (I) against TGF beta-induced collagen synthesis using 1.929 cells has been identified. For this, in 96-well plates, 1.929 cells were cultured in DMEM supplemented with % 10 serum, 10 μg/ml ascorbic acid and 20 μM prolin until they reached to confluency. Confluent cells were treated with 50 micromole of our compound (named as CP1) dissolved in DMSO for 1 hour, then 5 ng/ml of Mouse TGFβ2 was added and cells were further incubated for 72 hours at incubator supplied with 5% CO 2  and 80% humidity. At the end of this incubation one of the plate was used to determine cell viability by using MTT test,  FIG. 2 . The second 96-well plate was used to determine the level of total collagen. To determine the level of total collagen medium was removed and cells were fixed to bottom of the plated by adding % 0.5 gluteraldehyde prepared in 1×PBS for 30 minutes, then gluteraldehyde was removed, cells were washed with water and incubated with 100 microliter of 0.5 molar acetic acid for 30 minutes. At the end of 30 min, acetic acid was removed, cells were washed with water, air dried and 100 microliter “sircol dye solution” was added and further incubated for two hours at room temperature. Then, “sircol dye solution” was removed, plates was washed with water, air dried and 300 microliter of alkaline solution was added and shaken for 3 hours at room temperature to extract collagen-bound sircol. Absorbance of developed color was determined at 600 nm. As shown at  FIG. 1 , TGFβ induced collagen level by % 20 compared to control cells, however, in the presence of CP1 TGFβ induced collagen level by % 10, in other words CP1 inhibited TGFβ-induced collagen synthesis by % 50. In addition to total collagen, we also determined the level of “secreted collagen” by using ELISA. Briefly, supernatant (200 microliter) of cultured cells were transferred into “high affinity binding ELISA plates” and incubated this at 4° C. for 16 hours, then supernatant was removed, plate was washed with PBST (% 0.1 Tween-20 in 1×PBS) and blocked with % 1 BSA prepared in PBST for 2 hours, plate was washed with PBST and anti-collagen type I antibody (1:2000 dilution) prepared in % 1 BSA was added and incubated for 1 hour at room temperature, this antibody was removed, plate was washed with PBST and relevant secondary antibody prepared in % 1 BSA was added at 1:2000 dilution and incubated at room temperature for 1 hour, then secondary antibody was removed, plate was washed with PBST and ELISA was performed. As shown at  FIG. 3 , present compound (CP1) significantly inhibits TGFβ-induced secreted collagen level. These results strongly indicate that the compounds derived from CP1 may offer alternative treatment options to treat fibrosis patients. 
         [0124]    Structure of the above mentioned (CP1) compound is 6,7-dimethoxy 2H-chromen-2-one (1) and its chemical Formula is C 11 H 10 O 4   
         [0000]    
       
                 
         
             
             
         
       
     
         [0125]    With this application, carbonyl oxygen is removed from Chromene structure, this yielded positively charged chromene ring, then from this structure, 8 different molecules (4,5,6,7,8,9,10,11) and their 9 different combinations were generated. 
         [0126]    R1 and R2 positions of these 8 compound were chosen as site of modifications, and methyl(—CH3), ethyl(—C2H5), hydroxyl (—OH), and their combinations with one another were chosen to represent R and R2. 
         [0127]    Eight different structure and their derivatives are explained below; 
         [0128]    In the first compound (4), produced from main compound (2): when R1 and R2 are are methyl (—CH3), and in this compound (6,7-dimethoxy-chromenylium perchlorate(4.1) R3,R4,R5,R6 and R7 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0129]    In the first compound (4), produced from main compound (2); when R1 is ethyl (—C2H5) and R2 is methyl(—CH3), and in this compound (6-ethoxy-7 methoxy 2,3,4,5,8-pentamethyl naphatehalen-1-ylium (4.2); R3,R4,R5,R6 and R7 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0130]    In the first compound (4), produced from main compound (2); when R1 is methyl (—CH3) and R2 is ethyl(—C2H5), and in this compound (7-ethoxy-6-methoxy-2,3,4,5,8-pentamethyl naphatehalen-1-ylium (4.3) R3,R4,R5,R6 and R7 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0131]    In the first compound (4), produced from main compound (2); when R1 and R2 are ethyl(—C2H5), and in this compound (6,7-diethoxy-2,3,4,5,8-pentamethyl naphatehalen-1-ylium) (4.4); R3,R4,R5,R6 and R7 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 1 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0132]    In the first compound (4), produced from main compound (2): when R1 is hydroxyl (—OH) and R2 is methyl (—CH3), and in this compound (6-hydroperoxy-7-methoxy-2,3,4,5,8-pentamethylnaphatehalen-1-ylium) (4.5); R3,R4,R5,R6 and R7 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0133]    In the first compound (4), produced from main compound (2); when R1 is methyl (—CH3) and R2 is hydroxyl (—OH), and in this compound (7-hydroperoxy-6-methoxy-2,3,4,5,8-pentamethylnaphatehalen-1-ylium) (4.6); R3,R4,R5,R6 and R7 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0134]    In the first compound (4), produced from main compound (2); when R1 and R2 are hydroxyl (—OH), and in this compound (6,7-dihydroperoxy-2,3,4,5,8-pentamethylnaphatehalen-1-ylium) (4.7); R3,R4,R5,R6 and R7 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0135]    In the first compound (4), produced from main compound (2); when R1 is hydroxyl (—OH) and R2 is ethyl (—C2H5, and in this compound (7-ethoxy-6-hydroperoxy-2,3,4,5,8-pentamethylnaphatehalen-1-ylium) (4.8); R3,R4,R5,R6 and R7 can be: hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another in the first compound (4), produced from main compound (2); when R1 is ethyl (—C2H5) and R2 is hydroxyl (—OH), and in this compound (6-ethoxy-7-hydroperoxy-2,3,4,5,8-pentamethyl naphatehalen-1-ylium) (4.9) R3,R4,R5,R6 and R7 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another 
         [0136]    In the second compound (5), produced from main compound (2); when R1, R2, R11 and R12 are methyl (—CH3), and in this compound (2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6,7-dimethoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-(1:1) formaldehyde compound (5.1) R3,R4,R5,R6, R7,R8,R9 and R10 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0137]    In the second compound (5), produced from main compound (2); when R1 is ethyl (—C2H5) R2 is methyl (—CH3), R11 and R12 are methyl (—CH3 and in this compound (2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6-ethoxy-7-methoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-(1:1) formaldehyde compound) (5.2) R3,R4,R5,R6, R7,R8,R9 and R10 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0138]    In the second compound (5), produced from main compound (2); when R1 is methyl (—CH3), R2 is ethyl (—C2H5), R11 and R12 are methyl (—CH3) and in this compound (2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-7-ethoxy-6-methoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-(1:1) formaldehyde compound) (5.2) R3,R4,R5,R6, R7,R8,R9 and R10 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6 alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0139]    In the second compound (5), produced from main compound (2); when R1 and R2 are ethyl (—C2H5), R11 and R12 are methyl (—CH3) and in this compound (2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6,7-diethoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-(1:1) formaldehyde compound) (5.4) R3,R4,R5,R6, R7,R8,R9 and R10 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6 alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0140]    In the second compound (5), produced from main compound (2); when R1 is hydroxyl(—OH) R2 is methyl (—CH3), R11 methyl (—CH3), R12 methyl (—CH3) and in this compound (2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6-hydroperoxy-7-methoxy-3,4,5,8-tetramethyl-1λ 3 -chromen (1:1) formaldehyde compound) (5.5) R3,R4,R5,R6, R7,R8,R9 and R10 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6 alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0141]    In the second compound (5), produced from main compound (2): when R1, methyl (—CH3) R2 hydroxyl (—OH), R11 methyl (—CH3), R12 methyl (—CH3) and in this compound (2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6-hydroperoxy-7-methoxy-3,4,5,8-tetramethyl-1 λ 3 -chromen (1:1) formaldehyde compound) (5.6) R3,R4,R5,R6, R7,R8,R9 and R10 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 1 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6 alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0142]    In the second compound (5), produced from main compound (2); when R1 and R2 are hydroxyl (—OH), R11 methyl (—CH3), R12 methyl (—CH3) and in this compound (2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6,7-dihydroperoxy-3,4,5,8-tetramethyl-1λ 3 -chromen (1:1) formaldehyde compound) (5.7) R3,R4,R5,R6, R7,R8,R9 and R10 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0143]    In the second compound (5), produced from main compound (2); when R1 is hydroxyl(—OH) and R2 is ethyl (—C2H5), R11 methyl (—CH3), R12 methyl (—CH3), and in this compound (2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-7-ethoxy-6-hydroperoxy-3,4,5,8-tetramethyl-1λ 3 -chromen (1:1) formaldehyde compound) (5.8) R3,R4,R5,R6, R7,R8,R9 and R10 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6 alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0144]    In the second compound (5), produced from main compound (2); when R1 is ethyl (—C2H5), R2 is hydroxyl (—OH), R11 methyl (—CH3), R12 methyl (—CH3), and in this compound (2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6-ethoxy-7-hydroperoxy-3,4,5,8-tetramethyl-1λ 3 -chromen (1:1) formaldehyde compound) (5.9) R3,R4,R5,R6, R7,R8,R9 and R10 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 1 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0145]    In the third compound (6), produced from main compound (2); when R1 and R2 are methyl (—CH3), and in this compound (7-ethoxy-6-methoxy-2,3,4,5,8-pentamethyl naphatehalen-1-ylium (6.1) R3,R4,R5,R6 and R7 can be: hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0146]    In the third compound (6), produced from main compound (2); when R1 is ethyl (—C2H5) and R2 is methyl (—CH3), and in this compound (6,7-diethoxy-2,3,4,5,8-pentamethyl naphatehalen-1-ylium (6.2) R3,R4,R5,R6 and R7 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0147]    In the third compound (6), produced from main compound (2); when R1 is methyl (—CH3) and R2 is ethyl (—C2H5), and in this compound (6-methoxy-2,3,4,5,8-pentamethyl-7-propoxynaphatehalen-1-ylium (6.3) R3,R4,R5,R6 and R7 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6 alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0148]    In the third compound (6), produced from main compound (2); when R1 is ethyl (—C2H5) and R2 is ethyl (—C2H5), and in this compound (6-ethoxy-2,3,4,5,8-pentamethyl-7-propoxynaphatehalen-1-ylium (6.4) R3,R4,R5,R6 and R7 can be: hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6 alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0149]    In the third compound (6), produced from main compound (2); when R1 is hydroxyl(—OH) and R2 is methyl (—CH3), and in this compound (7-ethoxy-6-hydroperoxy-2,3,4,5,8-pentamethyl naphatehalen-1-ylium (6.5) R3,R4,R5,R6 and R7 can be: hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6 alkenyl, carboxyl (—COOH) and their combinations with one another 
         [0150]    In the third compound (6), produced from main compound (2); when R1 is methyl (—CH3) and R2 is hydroxyl (—OH), and in this compound (7-(hydroxymethoxy)-6-methoxy-2,3,4,5,8-pentamethyl naphatehalen-1-ylium (6.6); R3,R4,R5,R6 and R7 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6 alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0151]    In the third compound (6), produced from main compound (2); when R1 and R2 are hydroxyl (—OH), and in this compound (6-hydroperoxy-7-(hydroxymethoxy)-2,3,4,5,8-pentamethyl naphatehalen-1-ylium (6.7); R3,R4,R5,R6 and R7 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0152]    In the third compound (6), produced from main compound (2); when R1 is hydroxyl (—OH) and R2 is ethyl (—C2H5), and in this compound (6-hydroperoxy-2,3,4,5,8-pentamethyl-7-propoxynaphatehalen-1-ylium(6.8) R3,R4,R5,R6 and R7 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6 alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0153]    In the third compound (6), produced from main compound (2); when R1 is ethyl (—C2H5) and R2 is is hydroxyl (—OH), and in this compound (6-ethoxy-7-(hydroxymethoxy)-2,3,4,5,8-pentamethylnaphatehalen-1-ylium (6.9); R3,R4,R5,R6 and R7 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0154]    In the fourth compound (7), produced from main compound (2); when R1,R2,R1 and R12 are methyl (—CH3), and in this compound (2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-7-ethoxy-6-methoxy-3,4,5,8-tetramethyl-1λ 3 -chromen and methyl-λ 1 -oxidane (4:1:1) formaldehyde compound) (7.1); R3,R4,R5,R6, R7,R8,R9 and R10 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0155]    In the fourth compound (7), produced from main compound (2); when R1 is ethyl(—C2H5), R2 is methyl (—CH3), R11 and R12 are methyl (—CH3), and in this compound (2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6,7-diethoxy-3,4,5,8-tetramethyl-1λ 3 -chromen and methyl-λ 1 -oxidane (3:1:1) formaldehyde compound) (7.2) R3,R4,R5,R6, R7,R8,R9 and R10 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0156]    In the fourth compound (7), produced from main compound (2); when R1 is methyl(—CH3), R2 is ethyl (—C2H5), R11 and R12 are methyl (—CH3), and in this compound (2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6-methoxy-3,4,5,8-tetramethyl-7-propoxy-1λ 3 -chromen and methyl-λ 1 -oxidane (3:1:1) formaldehyde compound) (7.3) R3,R4,R5,R6, R7,R8,R9 and R10 can be: hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6 alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0157]    In the fourth compound (7), produced from main compound (2); when R1 and R2 are ethyl (—C2H5), R11 and R12 are methyl (—CH3), and in this compound (2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6-ethoxy-3,4,5,8-tetramethyl-7-propoxy-1λ 3 -chromen and methyl-λ 1 -oxidane (3:1:1) formaldehyde compound) (7.4) R3,R4,R5,R6, R7,R8,R9 and R10 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6 alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0158]    In the fourth compound (7), produced from main compound (2); when R1 is hydroxyl(—OH), R2 is methyl (—CH3), R11 and R12 are methyl (—CH3), and in this compound (2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-7-ethoxy-6-hydroperoxy-3,4,5,8-tetramethyl-1λ 3 -chromen and methyl-λ 1 -oxidane (3:1:1) formaldehyde compound) (7.5) R3,R4,R5,R6, R7,R8,R9 and R10 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0159]    In the fourth compound (7), produced from main compound (2); when R1 is methyl (—CH3), R2 is hydroxyl (—OH), R11 and R12 are methyl (—CH3), and in this compound (2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6-methoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-7-yl)oxy)methanol and methyl-λ 1 -oxidane (3:1:1) formaldehyde compound) (7.6) R3,R4,R5,R6, R7,R8,R9 and R10 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0160]    In the fourth compound (7), produced from main compound (2); when R1 and R2 are hydroxyl (—OH), R11 and R12 are methyl (—CH3), and in this compound (2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6-hydroperoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-7-yl)oxy)methanol and methyl-λ 1 -oxidane (3:1:1)) formaldehyde compound) (7.7) R3,R4,R5,R6, R7,R8,R9 and R10 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 1 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0161]    In the fourth compound (7), produced from main compound (2); when R1 is hydroxyl(—OH), R2 is ethyl (—C2H5), R11 and R12 are methyl (—CH3), and in this compound (2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6-hydroperoxy-3,4,5,8-tetramethyl-7-propoxy-1 λ 3 -chromen and methyl-λ 1 -oxidane (3:1:1) formaldehyde compound) (7.8) R3,R4,R5,R6, R7,R8,R9 and R10 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0162]    In the fourth compound (7), produced from main compound (2); when R1 is ethyl(—C2H5), R2 is hydroxyl (—OH), R11 and R12 are methyl (—CH3), and in this compound (2-(4-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-2-yl)-6-ethoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-7-yl)oxy)methanol and methyl-λ 1 -oxidane (3:1:1) formaldehyde compound) (7.9) R3,R4,R5,R6, R7,R8,R9 and R10 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0163]    In the fifth compound (8), produced from main compound (2); when R1 and R2 are methyl and in this compound (6-ethoxy 7-methoxy-2,3,4,5,8-pentamethylnaphatehalen-1-ylium (8.1); R3,R4,R5,R6 and R7 can be: hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0164]    In the fifth compound (8), produced from main compound (2); when R1 is ethyl(—C2H5) and R2 is methyl(—CH3), and in this compound (7-methoxy-2,3,4,5,8-pentamethyl-6-propoxynaphatehalen-1-ylium (8.2); R3,R4,R5,R6 and R7 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0165]    In the fifth compound (8), produced from main compound (2); when R1 is methyl(—CH3) and R2 is ethyl(—C2H5), and in this compound (6,7-diethoxy-2,3,4,5,8-pentamethylnaphatehalen-1-ylium (8.3) R3,R4,R5,R6 and R7 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0166]    In the fifth compound (8), produced from main compound (2); when R1 and R2 are ethyl (—C2H5), and in this compound (7-ethoxy-2,3,4,5,8-pentamethyl-6-propoxynaphatehalen-1-ylium (8.4); R3,R4,R5,R6 and R7 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0167]    In the fifth compound (8), produced from main compound (2); when R1 is hydroxyl (—OH), and R2 is methyl (—CH3) and in this compound (6-(hydroxymethoxy)-7-methoxy-2,3,4,5,8-pentamethylnaphatehalen-1-ylium (8.5); R3,R4,R5,R6 and R7 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0168]    In the fifth compound (8), produced from main compound (2); when R1 is methyl (—CH3), and R2 is hydroxyl (—OH), and in this compound (6-ethoxy-7-hydroperoxy-2,3,4,5,8-pentamethylnaphatehalen-1-ylium (8.6), R3,R4,R5,R6 and R7 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0169]    In the fifth compound (8), produced from main compound (2); when R1 and R2 are hydroxyl (—OH), and in this compound (7-hydroperoxy-6-(hydroxymethoxy)-2,3,4,5,8-pentamethylnaphatehalen-1-ylium (8.7), R3,R4,R5,R6 and R7 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6 alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0170]    In the fifth compound (8), produced from main compound (2); when R1 is hydroxyl (—OH), and R2 is ethyl (—C2H5), and in this compound (7-ethoxy-6-(hydroxymethoxy)-2,3,4,5,8-pentamethylnaphatehalen-1-ylium (8.8): R3,R4,R5,R6 and R7 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0171]    In the fifth compound (8), produced from main compound (2); when R1 is ethyl (—C2H5), R2 is hydroxyl (—OH), and in this compound (7-hydroperoxy-2,3,4,5,8-pentamethyl-6-propoxynaphatehalen-1-ylium (8.9); R3,R4,R5,R6 and R7 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0172]    In the sixth compound (9), produced from main compound (2); when R1,R2,R11 and R12 are methyl (—CH3), and in this compound (1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(6-ethoxy-7-methoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-2-yl)butan-1-one and methyl λ 1 -oxidane (3:1:1) formaldehyde compound(9.1); R3,R4,R5,R6,R7,R8,R9 and R10 can be: hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6 alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0173]    In the sixth compound (9), produced from main compound (2); when R1 is ethyl (—C2H5), R2 is methyl (—CH3), R11 and R12 are methyl (—CH3), and in this compound (3-(6,7-diethoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-2-yl)-1-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-1-one- and methyl-λ 1 -oxidane (3:1:1) formaldehyde compound(9.2); R3, R4, R5, R6, R7, R8, R9 and R10 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0174]    In the sixth compound (9), produced from main compound (2); when R1 is methyl (—CH3), R2 is ethyl (—C2H5), R11 and R12 are methyl (—CH3), and in this compound (1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(7-methoxy-3,4,5,8-tetramethyl-6-propoxy-1λ 3 -chromen-2-yl)butan-1-one and methyl λ 1 -oxidane (3:1:1) formaldehyde compound(93); R3,R4,R5,R6,R7,R8,R9 and R10 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0175]    In the sixth compound (9), produced from main compound (2); when R1 and R2 are ethyl (—C2H5), R11 and R12 are methyl (—CH3), and in this compound (I-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(7-ethoxy-3,4,5,8-tetramethyl-6-propoxy-1λ 3 -chromen-2-yl)butan-1-one and methyl λ 1 -oxidane (3:1:1) formaldehyde compound(9.4); R3,R4,R5,R6,R7,R8,R9 and R10 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0176]    In the sixth compound (9), produced from main compound (2); when R1 is hydroxyl (—OH), R2 is methyl (—CH3), R11 and R12 are methyl (—CH3), and in this compound (1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(6-(hydroxymethoxy)-7-methoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-2-yl)butan-1-one and methyl λ 1 -oxidane (3:1:1) formaldehyde compound(9.5); R3,R4,R5,R6,R7,R8,R9 and R10 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0177]    In the sixth compound (9), produced from main compound (2); when R1 is methyl (—CH3), R2 is hydroxyl(—OH), R11 and R12 are methyl (—CH3), and in this compound (1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(6-ethoxy-7-hydroperoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-2-yl)butan-1-one-and methyl-λ 1 -oxidane (3:1:1) formaldehyde compound(9.6); R3,R4,R5,R6,R7,R8,R9 and R10 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0178]    In the sixth compound (9), produced from main compound (2); when R1 and R2 are hydroxyl (—OH), R11 and R12 are methyl (—CH3), and in this compound (1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(7-hydroperoxy-6-(hydroxyperoxy)-3,4,5,8-tetramethyl-1λ 3 -chromen-2-yl)butan-1-one and methyl-λ 1 -oxidane (3:1:1) formaldehyde compound (9.7); R3,R4,R5,R6,R7,R8,R9 and R10 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0179]    In the sixth compound (9), produced from main compound (2); when R1 is hydroxyl (—OH), R2 is ethyl (—C2H5), R11 and R12 are methyl (—CH3), and in this compound (1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(7-ethoxy-6-(hydroxyperoxy)-3,4,5,8-tetramethyl-1λ 3 -chromen-2-yl)butan-1-one and methyl λ 1 -oxidane (3:1:1) formaldehyde compound (9.8); R3,R4,R5,R6,R7,R8,R9 and R10 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0180]    In the sixth compound (9), produced from main compound (2); when R1 is ethyl (—C2H5), R2 is hydroxyl (—OH), R11 and R12 are methyl (—CH3), and in this compound (1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(7-hydroperoxy-3,4,5,8-tetramethyl-6-propoxy-1λ 3 -chromen-2-yl)butan-1-one and methyl λ 1 -oxidane (3:1:1) formaldehyde compound (9.9); R3,R4,R5,R6,R7,R5,R9 and R10 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0181]    In the seventh compound (10), produced from main compound (2); when R1 and R2 are methyl (—CH3), and in this compound (6,7-diethoxy-2,3,4,5,8-pentamethylnaphatehalen-1-ylium(10.1); R3,R4,R5,R6 and R7 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0182]    In the seventh compound (10), produced from main compound (2): when R1 is ethyl (—C2H5) and R2 is methyl (—CH3), and in this compound 7-ethoxy-2,3,4,5,8-pentamethyl-6-propoxynaphatehalen-1-ylium (10.2); R3,R4,R5,R6 and R7 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6 alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0183]    In the seventh compound (10), produced from main compound (2); when R1 is methyl (—CH3) and R2 is ethyl (—C2H5), and in this compound 6-ethoxy-2,3,4,5,8-pentamethyl-7-propoxynaphatehalen-1-ylium (10.3); R3,R4,R5,R6 and R7 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0184]    In the seventh compound (10), produced from main compound (2); when R1 and R2 are ethyl (—C2H5), and in this compound 2,3,4,5,8-pentamethyl-6,7-dipropoxynaphatehalen-1-ylium (10.4); R3,R4,R5,R6 and R7 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H1-15), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0185]    In the seventh compound (10), produced from main compound (2); when R1 is hydroxyl (—OH) and R2 is methyl (—CH3), and in this compound 7-ethoxy-6-(hydroxymethoxy)-2,3,4,5,8-pentamethylnaphatehalen-1-ylium (10.5); R3,R4,R5,R6 and R7 can be; hydrogen, (—H), hydroxyl, (—CL), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0186]    In the seventh compound (10), produced from main compound (2); when R1 is methyl (—CH3) and R2 is hydroxyl (—OH), and in this compound 6-ethoxy-7-(hydroxymethoxy)-2,3,4,5,8-pentamethylnaphatehalen-1-ylium (10.6); R3,R4,R5,R6 and R7 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6 alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0187]    In the seventh compound (10), produced from main compound (2): when R1 and R2 are hydroxyl (—OH), and in this compound 6,7-bis(hydroxymethoxy)-2,3,4,5,8-pentamethylnaphatehalen-1-ylium (10.7) R3,R4,R5,R6 and R7 can be: hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6 alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0188]    In the seventh compound (10), produced from main compound (2): when R1 is hydroxyl(—OH) and R2 is ethyl (—C2H5), and in this compound 6-(hydroxymethoxy)-2,3,4,5,8-pentamethyl-7-propoxynaphatehalen-1-ylium (10.8); R3,R4,R5,R6 and R7 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0189]    In the seventh compound (10), produced from main compound (2); when R1 is ethyl (—C2H5) and R2 is hydroxyl(—OH), and in this compound 7-(hydroxymethoxy)-2,3,4,5,8-pentamethyl-6,7-propoxynaphatehalen-1-ylium (10.9); R3,R4,R5,R6 and R7 can be: hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0190]    In the eight compound (11), produced from main compound (2); when R1,R2,R11 and R12 are methyl (—CH3), and in this compound (3-(6,7-diethoxy-3,4,5,8-tetramethyl-1λ 3 -chromen-2-yl)-1-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-1-one-and methyl-λ 1 -oxidane (3:1:1) formaldehyde compound (11.1); R3,R4,R5,R6,R7,R8,R9 and R10 can be: hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6 alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0191]    In the eight compound (11), produced from main compound (2); when R1 is ethyl (—C2H5), R2 is methyl (—CH3) R11 and R12 are methyl (—CH3) and in this compound (1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(7-ethoxy,3,4,5,8-tetramethyl-6-propoxy-1λ 3 -chromen-2-yl)butan-1-one-methyl-λ 1 -oxidane(3:1:1) formaldehyde compound (11.2); R3,R4,R5,R6,R7,R8,R9 and R10 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0192]    In the eight compound (11), produced from main compound (2): when R1 is methyl (—CH3), R2 is ethyl (—C2H5), R11 and R12 are methyl (—CH3) and in this compound (1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(6-ethoxy-3,4,5,8-tetramethyl-7-propoxy-1λ 3 -chromen-2-yl)butan-1-one-methyl-λ 1 -oxidane (3:1:1) formaldehyde compound (11.3); R3,R4,R5,R6,R7,R8,R9 and R10 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0193]    In the eight compound (11), produced from main compound (2); when R land R2 are ethyl (—C2H5), R11 and R12 are methyl (—CH3) and in this compound (1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(0,3,4,5,8-tetramethyl-6,7-dipropoxy-1λ 3 -chromen-2-yl)butan-1-one-methyl-λ 1 -oxidane(3:1:1) formaldehyde compound (11.4); R3,R4,R5,R6,R7,R8,R9 and R10 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0194]    In the eight compound (11), produced from main compound (2); when R1 is hydroxyl (—OH), R2 is methyl (—CH3), R11 and R12 are methyl (—CH3) and in this compound (1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(7-ethoxy-6-(hydroxyperoxy)-3,4,5,8-tetramethyl-1λ 3 -chromen-2-yl)butan-1-one and methyl λ 1 -oxidane (3:1:1) formaldehyde compound (11.5); R3,R4,R5,R6,R7,R8,R9 and R10 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0195]    In the eight compound (11), produced from main compound (2); when R1 is methyl (—CH3), R2 is hydroxyl (—OH), R11 and R12 are methyl (—CH3) and in this compound (1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(6-ethoxy-7-(hydroxymethoxy)-3,4,5,8-tetramethyl-1λ 3 -chromen-2-yl)butan-1-one-and-methyl-λ 1 -oxidane(3:1:1) formaldehyde compound (11.6); R3,R4,R5,R6,R7,R8,R9 and R10 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0196]    In the eight compound (11), produced from main compound (2); when R1 and R2 are hydroxyl (—OH), R11 and R12 are methyl (—CH3) and in this compound (3-(6,7-bis(hydroxymethoxy)-3,4,5,8-tetramethyl-1λ 3 -chromen-2-yl)-1-(3,4-dimethoxy-2,5,6-trimethylphenyl)butan-1-one-and-methyl-λ 1 -oxidane(3:1:1) formaldehyde compound (11.7); R3,R4,R5,R6,R7,R8,R9 and R10 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0197]    In the eight compound (11), produced from main compound (2); when R1 is hydroxyl (—OH), R2 is ethyl (—C2H5), R1 and R12 are methyl (—CH3) and in this compound 1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(6-(hydroxymethoxy)-(3,4,5,8-tetramethyl-7-propoxy-1λ 3 -chromen-2-yl)butan-1-one-and-methyl-λ 1 -oxidane(3:1:1) formaldehyde compound (11.8); R3,R4,R5,R6,R7,R8,R9 and R10 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another. 
         [0198]    In the eight compound (11), produced from main compound (2); when R1 is ethyl (—C2H5), R2 is hydroxyl (—OH), R11 and R12 are methyl (—CH3) and in this compound (1-(3,4-dimethoxy-2,5,6-trimethylphenyl)-3-(7-(hydroxymethoxy)-(3,4,5,8-tetramethyl-6-propoxy-1λ 3 -chromen-2-yl) butan-1-one-and-methyl-λ 1 -oxidane(3:1:1) formaldehyde compound (11.9); R3,R4,R5,R6,R7,R8,R9 and R10 can be; hydrogen, (—H), hydroxyl, (—OH), fluoride (—F), chloride, (—CL), bromide (—Br), iodine (—I), methyl (—CH3), ethyl (—C2H5), amino (—NH2), nitro (—NO2), C 3 -C 6  cycloalkenyl, C 1 -C 6  alkoxide, C 1 -C 6  alkyl, C 1 -C 6  fluoroalkyl, C 2 -C 6  alkenyl, carboxyl (—COOH) and their combinations with one another.