Abstract:
A clamping and cutting device that has a blade and blade receptacle aspect of the cutting mechanism with open clamping mechanisms that are actuated in a step-wise fashion due to a mechanical timing mechanism.

Description:
CROSS-REFERENCE TO RELATED APPLICATION 
       [0001]    This application is a continuation of International Application No. PCT/US2015/061821, filed Nov. 20, 2015, entitled “Multi-Component Detachable Cutting and Clamping Tool and Methods of Using Same,” which claims priority under 35 USC §119(e) and to U.S. Provisional Patent Application Ser. No. 62/082,723, filed Nov. 21, 2014, entitled “Multi-Component Detachable Cutting and Clamping Tool and Methods of Using and Making Same,” the disclosures of which are incorporated herein in their entirety. 
     
    
     BACKGROUND 
       [0002]    Field of the Invention 
         [0003]    Disclosed embodiments relate to a multi-component detachable cutting and clamping tool in the technical field of medical devices, and more particularly in the technical field of obstetric medical devices. 
         [0004]    Background 
         [0005]    Maternal and infant infections represent one of the most common complications of childbirth in developing countries where most infants are born worldwide. In developing nations where health care infrastructure is commonly limited, most deliveries occur outside a hospital setting with help from family or birth attendants, resulting in up to half of all mothers and newborns not receiving skilled care during and immediately after birth. Nearly all (99%) of newborn deaths occur in low- to middle-income countries, where most birth practices involve severing the umbilical cord using non-sterile or incompletely sterile instruments that can lead to infection. It is believed that effective prenatal and postnatal care, including treatment of maternal infections during pregnancy, ensuring a clean birth, care of umbilical cord, and immediate breastfeeding could reduce up to 75% of infant deaths occurring under one-month. For these reasons, cost-effective, non-reusable, safe, and easy-to-use clamping and cutting implements are necessary components of helping reduce neonatal mortality in developing countries. In addition, tracking infant and maternal outcomes both in and outside of hospital settings in some developing countries can be difficult and so unique identifiers or radiofrequency identification (RFID) tags embedded within novel umbilical cord clamping and cutting devices or other surgical instruments could be used to improve outcome tracking. These unique identifiers could be combined with low-cost SMS-based or internet-enabled repositories or databases so that detailed analysis can be performed by aid organizations or governments so that appropriate interventions or policies may be utilized. 
         [0006]    In developed countries, umbilical cord infections are relatively uncommon, however, additional challenges remain. The current limitations of the procedure in developed countries include: procedure duration, infant security/identification, cost, number of instruments required for both placement and sometimes removal of clamps prior to discharge from the hospital, usability, and difficulty in collecting umbilical cord blood once permanent clamps are applied. The increased duration and cost of the procedure are due to the number of reusable and disposable implements required and the need to coordinate movements accurately in a critical point in the birthing process, especially for high-risk infants and mothers. Infant security and identification is necessary in preventing infants being mistaken, lost, or stolen. While this is an uncommon occurrence, it is considered a never-event with significant resources allocated for prevention. Infant security and identification is most commonly addressed through obvious devices or bands applied either to the infant&#39;s wrist or on the clamping implement. The obvious nature of these security devices represents a fundamental weakness in infant protection. Beyond the use of unique identifiers or embedded RFID tags, local identifiers, for example, a logo of the birthing facility or color-based system, could be used to allow emergency personnel to better care for abandoned infants. 
         [0007]    The first few weeks of a newborn mammal&#39;s life are critical to its long-term survival and health. Umbilical cord care is just as important in veterinary use as it is in human use, especially since the environment an animal is born into is usually less sterile than that of a human birth. The umbilical cord is usually severed immediately after a birth, and typically a disinfectant is applied to prevent pathogens from entering an animal&#39;s body through the cord. Umbilical cord devices can be used in veterinary medicine as an effective way to prevent umbilical cord bleeding and infection in the first few days of life. Large animal births, in particular, could benefit from an improved means of severing the umbilical cord, as many large animal births are not attended by a trained veterinarian but by a livestock handler. 
         [0008]    A key disadvantage of the present umbilical cord clamping and cutting method in both developed and developing markets is its multi-step nature. The procedure of severing the umbilical cord in developed countries involves multiple pieces of equipment: hemostats, plastic clamps, and a cutting implement. In practice, two metal hemostats are secured to the umbilical cord in a spaced relation to one another, and the cord is then cut between the two clamps using scissors. Due to the material properties of the umbilical cord and its slippery nature after birth, this method often requires two hands and multiple attempts to sever. The metal hemostat on the baby&#39;s side is then replaced with a permanent plastic clamp and the other is removed when the placenta is discarded. Prior to leaving the hospital facility, the permanent plastic clamp is usually removed, requiring an additional hinge cutting device. In developing countries, the method for severing the umbilical cord often involves the use of clamping implements or devices, usually a type of string or plastic clamp, to stop the flow of blood and a sharp blade, often contaminated or reused, to sever the cord between the two clamped areas. There are clear opportunities for innovation in these areas. 
         [0009]    Various surgical instruments and devices have been developed to separate and clamp the umbilical cord joining a newborn infant and the mother, however, most are reusable, difficult to use, and/or are not cost-effective. Reusability is an understandable health concern due to the possibility of contamination and subsequent infection; those that claim not to be reusable still utilize a metallic cutting implement that can be removed and reused. The metallic blade is problematic for several reasons: it is a safety hazard, can corrode prior to use, there is a risk of the blade being removed for reuse, and it is less economical to manufacture and distribute. In addition, variations on obstetric scissors do not provide adequate protection from unintended blood splatter, placing the infant, mother, and birth attendant at risk from contracting blood-borne pathogens, including HIV and Hepatitis viral infections. Furthermore, it is usually necessary to first orient the device so that the clamp side with the blade remains on the mother&#39;s side of the cord to be discarded with the placenta. Improper orientation or use of such devices is more likely to occur in developing nations due to difficulties in training and language barriers. 
         [0010]    The phrase “elongate biological organ” as used herein is intended to connote an umbilical cord, an artery, a vein, a capillary, a conduit, a tube, a duct, and in general any flexible and/or deformable member which is capable of being clamped and then severed. Although the present invention will be referred to hereinafter in connection with the clamping and severing of an umbilical cord, the invention is not to be taken limited solely to use in connection with umbilical cords. 
         [0011]    While certain novel features of this embodiment are shown and described below, it is not intended to be limited to the details specified, since a person of ordinary skill in the relevant art will understand that various omissions, modifications, substitutions and changes in the forms and details illustrated and in its operation may be made without departing in any way from the spirit of the embodiment. No feature is critical or essential unless it is expressly stated as being “critical” or “essential.” 
       SUMMARY 
       [0012]    This application discloses a cutter clamp assembly that can cut and clamp an elongate biological organ, such as an umbilical cord, having a cutter assembly and one or more clamps. 
     
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         [0013]      FIGS. 1A-C  are schematic illustrations of a cutter clamp assembly according to an embodiment. 
           [0014]      FIGS. 2A-C  are schematic illustrations of the cutter assembly of the cutter clamp assembly of  FIGS. 1A-C  in open, partially closed, and fully closed configurations, respectively. 
           [0015]      FIGS. 3A-B  are schematic illustrations of a clamp of the cutter clamp assembly of  FIGS. 1A-C  in open and closed configurations, respectively. 
           [0016]      FIG. 4  is a schematic illustration of the cutter clamp assembly of  FIGS. 1A-C  with a clamp in the closed configuration and the cutter assembly in the partially closed configuration, and an elongate biological organ disposed in the cutter clamp assembly. 
           [0017]      FIG. 5  is a flow chart illustrating a method of cutting and clamping an elongate biological organ, according to an embodiment. 
           [0018]      FIGS. 6A-B  are perspective views of a cutter clamp assembly according to another embodiment, in an open configuration. 
           [0019]      FIG. 6C  is a perspective view of the cutter clamp assembly of  FIG. 6A-B  in a fully closed configuration. 
           [0020]      FIGS. 7A-B  are perspective views of the cutter assembly of the cutter clamp assembly of  FIGS. 6A-C  in open and fully closed configurations, respectively. 
           [0021]      FIGS. 8A-B  are perspective views of the blade portion and blade receptacle portion, respectively, of the cutter assembly of  FIGS. 7A-B . 
           [0022]      FIGS. 9A-C  are perspective views of a clamp of the cutter clamp assembly of  FIGS. 6A-C  in an open configuration. 
           [0023]      FIG. 9D  is a perspective view of the claim of  FIGS. 9A-C  in a closed configuration. 
           [0024]      FIGS. 10A-B  are perspective views of the cutter clamp assembly of  FIGS. 6A-C  disposed about an elongate biological organ and after cutting and clamping the organ, respectively. 
           [0025]      FIG. 10C  is a perspective view of a claim of the cutter clamp assembly of  FIGS. 10A-B , clamped to the cut end of the organ. 
           [0026]      FIG. 11  is perspective view of a cutter clamp assembly having a ratchet, according to an embodiment, in an open configuration. 
           [0027]      FIG. 12  is a perspective view of a cutter clamp assembly having a ratchet and excluding a cutter assembly latch, according to an embodiment, in an open configuration. 
       
    
    
     DETAILED DESCRIPTION 
       [0028]    Apparatus and methods for performing a procedure to cut and clamp an elongate biological organ, such as an umbilical cord, are described herein. In some embodiments, a method for cutting and clamping an elongate biological organ includes disposing about an elongate biological organ (e.g., an umbilical cord) a cutter clamp assembly. The cutter clamp assembly has a clamp with a lower jaw portion and an upper jaw portion coupled for relative movement between an open configuration defining an organ receiving zone therebetween and a closed configuration defining a clamped zone therebetween. The cutter clamp assembly includes a cutter assembly having a blade portion and a blade receptacle portion coupled for relative movement between a first, open configuration, a second, partially closed configuration, and a third, fully closed configuration. The blade portion includes a blade projecting toward the receptacle portion. 
         [0029]    The cutter assembly defines a cutting zone between the blade portion and the blade receptacle portion. The blade is at least partially clear of the cutting zone when the cutter assembly is disposed in the partially closed configuration and the blade is disposed across the cutting zone when the cutter assembly is disposed in the fully closed configuration. The cutter assembly is releasably coupled to the clamp with the clamped zone of the clamp disposed laterally adjacent to the cutting zone of the cutter assembly. 
         [0030]    The cutter clamp assembly further includes a cutting timer mechanism configured such that relative movement of the blade portion and the blade receptacle portion between the open configuration and the partially closed configuration of the cutter assembly produces relative movement of the upper jaw portion and the lower jaw portion between the open configuration and the closed configuration of the clamp. The cutting timer mechanism is configured to permit further relative movement of the blade portion and the blade receptacle portion between the partially closed configuration and the fully closed configuration of the cutter assembly without further relative movement of the upper jaw portion and the lower jaw portion of the clamp. 
         [0031]    With the cutter clamp assembly disposed about the elongate biological organ, or more specifically, with a first portion of the organ disposed in the organ receiving zone of the clamp, and a second portion of the organ disposed in the cutting zone of the cutter assembly, manual pressure can be applied to the blade portion and the blade receptacle portion of the cutter assembly to urge the cutter assembly from the open configuration to the partially closed configuration and thus to urge the clamp from the open configuration to the closed configuration and to clamp the first portion of the elongate biological organ. 
         [0032]    Further manual pressure can be applied to the blade portion and the blade receptacle portion to urge the cutter assembly from the partially closed configuration to the fully closed configuration and to cut the second portion of the organ. Upon cutting of the second portion of the organ, the clamp can be separated from the cutter assembly, with the clamp at least temporarily retained on the second portion of the organ. 
         [0033]    In some embodiments, a cutter clamp assembly is provided to perform the above cutting and clamping procedure. Such an assembly can include, for example, a clamp, a cutter assembly, and a cutting timer mechanism. The clamp can include a lower jaw portion and an upper jaw portion coupled for relative movement between a first, open configuration and a second, closed configuration. The clamp can define between the upper jaw portion and the lower jaw portion an organ receiving zone in the open configuration of the clamp and a clamped zone between the upper jaw portion and the lower jaw portion in the closed configuration of the clamp. The clamp can be configured to receive a first portion of an elongate compressible biological organ in the organ receiving zone and to compress the received first portion of the organ between the upper jaw portion and the lower jaw portion into the clamped zone. 
         [0034]    The cutter assembly of the cutter clamp assembly can include a first portion and a second portion coupled for relative movement between a first, open configuration, a second, partially closed configuration, and a third, fully closed configuration. Either the first portion or the second portion can include a blade projecting toward the other of the first portion and the second portion. The cutter assembly can further define a cutting zone between the first portion and the second portion such that the blade is at least partially clear of the cutting zone when the cutter assembly is disposed in the partially closed configuration, and the blade is disposed completely across the cutting zone when the cutter assembly is disposed in the fully closed configuration. 
         [0035]    The cutter assembly can be releasably coupled to the clamp by a mounting connection between the lower jaw portion of the clamp and the second portion of the cutter assembly, with the clamped zone of the clamp disposed laterally adjacent to the cutting zone of the cutter assembly, such that a second portion of the elongate biological organ can be received in the cutting zone when the first portion of the organ is disposed in the clamped zone. 
         [0036]    The cutting timer mechanism of the cutter clamp assembly can include a first timer portion disposed on the upper jaw portion of the clamp and a second timer portion disposed on the first portion of the cutter assembly. The first timer portion can be engageable with the second timer portion such that relative movement of the first portion and the second portion of the cutter assembly between the open configuration and the partially closed configuration of the cutter assembly produces relative movement of the upper jaw portion and the lower jaw portion between the open configuration and the closed configuration of the clamp. The cutting timer mechanism can be configured to permit further relative movement of the first portion and the second portion of the cutter assembly between the partially closed configuration and the fully closed configuration of the cutter assembly without further relative movement of the upper jaw portion and the lower jaw portion of the clamp. 
         [0037]      FIG. 1A  is a schematic illustration of a cutter clamp assembly, according to an embodiment. The cutter clamp assembly  1000  can include a cutter assembly  1100  configured to cut an elongate biological organ, a first clamp  1200  configured to clamp a portion of the organ and removably coupled to the cutter assembly  1100  via a first clamp mount  1300 , a second clamp  1400  configured to clamp a portion of the organ and removably coupled to the cutter assembly  1100  via a second clamp mount  1500 , and a cutting timer mechanism  1600  coupled to the cutter assembly  1100  and the first clamp  1200 . 
         [0038]    The cutter clamp assembly  1000  can be disposed about an elongate biological organ O (also referred to herein as “organ”), as shown in  FIG. 1B . More specifically, the organ O can be placed in a desired position relative to the cutter clamp assembly  1000  in which a first portion of the organ O is disposed in a cutting zone of the cutter assembly  1100 , a second portion of the organ O is disposed in an organ receiving zone of the first clamp  1200 , and a third portion of the organ O is disposed in an organ receiving zone of the second clamp  1400 , the first portion of the organ O being disposed between both the second and third portions of the organ O. When the organ O is in the desired position relative to the cutter clamp assembly  1000 , the cutter clamp assembly  1000  can be actuated to transition (1) the first clamp  1200  from its open configuration to its closed configuration and to clamp the second portion of the organ O, and (2) the second clamp  1400  from its open configuration to its closed configuration and to clamp the third portion of the organ O. 
         [0039]    The cutter clamp assembly  1000  can be further actuated to transition the cutter assembly  1100  from its open configuration to its closed configuration and to cut the first portion of the organ. In some embodiments, when the cutter clamp assembly  1000  is actuated to transition the first clamp  1200  to its closed configuration and the second clamp  1400  to its closed configuration, the cutter assembly  1100  is also transitioned. In such embodiments, upon actuation of the cutter clamp assembly  1000 , the cutter assembly  1100  is transitioned from its open configuration to a partially closed configuration. Upon proper clamping of the organ O between the first clamp  1200  and the second clamp  1400 , the cutter assembly  1000  can be further actuated to transition the cutter assembly  1100  from its partially closed configuration to a fully closed configuration and to cut the first portion of the organ. In this manner, the cutter clamp assembly  1000  can both clamp and cut an organ O in response to a continuous force or movement applied to the cutter clamp assembly  1000 , e.g., a continuous manual movement provided by an operator of the cutter clamp assembly  1000 . Enabling both cutting and clamping in response to a continuous manual movement can simplify the procedure and promote repeatable safe and effective operations. 
         [0040]    As shown in  FIG. 1C , after the cutter clamp assembly  1000  has clamped and cut the organ O, the first clamp  1200  and the second clamp  1400  can be decoupled or otherwise separated from the cutter assembly  1100 , with the first clamp  1200  removably coupled to or retained on the second portion of the organ O and the second clamp  1400  removably coupled to or retained on the third portion of the organ O. For example, during a procedure on an umbilical cord, after the cutter clamp assembly  1000  has clamped and cut the umbilical cord, the first clamp  1200  and the second clamp  1400  can be separated from the cutter assembly  1100 , with the first clamp  1200  retained on a portion of the umbilical cord that is attached to a placenta, and the second clamp  1400  retained on a portion of the umbilical cord that is attached to a newborn. 
         [0041]    Upon separation of both the first clamp  1200  and the second clamp  1400  from the cutter assembly  1100 , one or both of the first clamp  1200  and the second clamp  1400  can be independently transitioned from its closed configuration to its opened position to separate one or both of the first clamp  1200  and the second clamp  1400  from the organ O, to sample contents of the organ O, or to readjust one or both of the first clamp  1200  and the second clamp&#39;s  1400  position relative to the organ O and then independently re-transition one or both of the first clamp  1200  and the second clamp  1400  from its opened configuration to its closed configuration to re-clamp the organ O. 
         [0042]    Although the cutter clamp assembly  1000  has been shown and described as having two clamps (i.e., the first clamp  1200  and the second clamp  1400 ), in other embodiments, the cutter clamp assembly  1000  can have any suitable number of clamps configured to clamp a portion or portions of an elongate biological organ. For example, in alternative embodiments, a cutter clamp assembly can include only one clamp configured to clamp a portion of an elongate biological organ. 
         [0043]    In some embodiments, the clamp(s) (e.g., the first clamp  1200  and/or the second clamp  1400 ) can include one or more indicia of identification. Indicia of identification, for example, can include a unique identification code or symbol, radio-frequency identification (RFID), a bar code, a logo, a color code, etc. The indicia of identification can be associated with, for example, a particular health care facility, a particular patient or relative of the patient, a particular geographical region, etc. In some instances, for example in developed countries, the indicia of identification can help identify abandoned newborns, and in developing countries, the indicia of identification can aid in the collection of regional and national health outcome statistics. In some embodiments, alternatively or in addition to the indicia of identification on the one or more clamps, indicia of identification can be disposed on the cutter assembly. 
         [0044]    In some embodiments, the clamps (e.g., the first clamp  1200  and the second clamp  1400 ) can include matching or corresponding identification or visual indicium. For example, after an umbilical cord procedure (i.e., after clamping and cutting of the umbilical cord), the clamp attached to the placenta side of the cord can be matched to the clamp attached to the newborn side of the cord. In this manner, a health care practitioner, for example, can identify or match the placenta to the corresponding newborn from which it was previously attached. 
         [0045]      FIGS. 2A-C  are schematic illustrations of the cutter assembly  1100  of the cutter clamp assembly  1000  of  FIGS. 1A-C  in open, partially closed, and fully closed configurations, respectively. As shown, the cutter assembly  1100  includes a blade receptacle portion  1120  and a blade portion  1110  rotationally coupled or hinged to the blade receptacle portion  1120  via a cutter assembly hinge  1160 . The cutter assembly hinge  1160  is configured to promote relative angular movement or otherwise provide a pivot point between the blade portion  1110  and the receptacle portion  1120 . In this manner, as discussed above with respect to  FIGS. 1A-1C , transition of the cutter assembly  1100  between configurations (e.g., open configuration, partially closed configuration, fully closed configuration) can include the blade portion  1110  and the blade receptacle portion  1120  rotating relative to each other about the cutter assembly hinge  1160 . A cutting zone  1180  is defined between the blade portion  1110  and the blade receptacle portion  1122 . As shown, the cutting zone  1180  is defined at least partially within the blade receptacle  1122 . 
         [0046]    The blade portion  1110  includes a blade  1112  configured to pierce or cut the organ O when placed into contact with the organ O. As shown, the blade  1112  projects toward the blade receptacle portion  1122 . As shown across  FIGS. 2A-2C , when the cutter assembly  1100  is in its open configuration ( FIG. 2A ), the blade  1112  is clear of the cutting zone  1180 . When the cutter assembly  1100  is in its partially closed configuration ( FIG. 2B ), the blade  1112  is at least partially clear of the cutting zone  1180 . When the cutter assembly  1100  in in its fully closed configuration ( FIG. 2C ), the blade  1112  is disposed completely across the cutting zone. In such embodiments, in use, in some instances, the blade  1112  may make contact with and at least partially pierce (e.g., prior to severance of the organ O) the organ O when the cutter assembly  1100  is in its partially closed configuration. In alternative embodiments, unlike as illustrated in  FIG. 2B , the blade may be completely clear of the cutting zone when the cutter assembly is disposed in its partially closed configuration. 
         [0047]    The blade  1112  can be shaped and sized in any suitable manner configured to cut the organ O. For example, in some embodiments, the blade  1112  can be constructed at least partially from non-metallic materials to promote safety for users and patients of the cutter clamp assembly  1000 . As such, the blade  1112  can be configured to cut an elongate biological organ while limiting the blade&#39;s  1112  ability to undesirably cut, for example, a finger of a user of the cutter clamp assembly  1000 . Further, the non-metallic construction of the blade  1112  can limit or prevent reuse or multiple reuses of the cutter clamp assembly  1000 , thereby limiting or reducing the likelihood of insanitary uses of the cutter clamp assembly  1000 . Even further, the non-metallic construction of the blade  1112  can promote a more cost-effective cutter clamp assembly  1000 , due in part to the cost-effective manufacturing processes (e.g., injection molding) available in connection with such materials. As a further example, in some embodiments, the blade  1112  can be constructed from degradable materials (e.g., a degradable polymer) to reduce waste and waste collection, particularly for example, in developing countries or regions without suitable and safe waste collection. As a further example, in some embodiments, the blade  1112  can be constructed with anti-microbial additive materials (e.g., an antimicrobial composite polymer) to discourage colonization of a bacterial, for example, in developing countries or regions. The blade  1112  and the blade portion  1110  can be monolithically formed, or alternatively, the blade  1112  and the blade portion  1110  can be formed separately and then joined together. 
         [0048]    The blade receptacle portion  1120  defines a blade receptacle  1122  configured to receive a portion of the blade  1112 . For example, when the cutter assembly  1100  is in its fully closed configuration ( FIG. 2C ), a portion of the blade  1112  is disposed across or within the blade receptacle  1122 . In this manner, in use, the blade  1112  can sever and pass through a portion of the organ as the blade  1112  transitions from being clear of the cutter zone  1180  to at least partially being disposed within the receptacle  1122 . 
         [0049]    To cut an elongate biological organ (e.g., an umbilical cord), the cutter assembly  1100  can be manipulated from a first, open configuration, to a second, partially closed configuration, to a third, fully closed configuration, as shown in sequence in  FIGS. 2A-2C , respectively. With the cutter assembly  1100  disposed about the organ (i.e., between the blade portion  1110  and the blade receptacle portion  1120 , the cutter assembly  1100  can be manipulated (e.g., by a manual force applied by a user to the blade portion  1110  and/or the blade receptacle portion  1120 ) to transition the cutter assembly  1100  from its open configuration ( FIG. 2A ) to its partially closed configuration ( FIG. 2B ). Although not shown in  FIG. 2B , as described above with reference to  FIGS. 1A-1C , and described further herein with respect to  FIGS. 3A, 3B and 4 , the first clamp  1200  and the second clamp  1400  are configured to clamp portions of the organ when the cutter assembly  1100  is in its partially closed configuration ( FIG. 2B ) and coupled to the first clamp  1200  and the second clamp  1400 . 
         [0050]    As shown in sequence from  FIGS. 2B to 2C , the cutter assembly  1100  can be further manipulated (e.g., by the manual force) to transition the cutter assembly  1100  from its partially closed configuration ( FIG. 2B ) to its fully closed configuration ( FIG. 2C ) (i.e., the blade portion  1110  and the blade receptacle portion pivot about the cutter assembly hinge  1160 ) and to cut or sever the organ (not shown). As shown in  FIG. 2C , the blade  1112  of the blade portion  1110  is disposed within the blade receptacle  1122  of the blade receptacle portion  1120  when the cutter assembly  1100  is in its fully closed configuration. When the cutter assembly  1100  is in its fully closed configuration ( FIG. 2C ), the cutter assembly latch  1170  can be actuated to lock or limit relative movement between the blade portion  1110  and the blade receptacle  1122 . 
         [0051]    In some embodiments, the cutter assembly latch  1170  can be reversibly actuate-able such that the latch  1170  can temporarily lock the cutter assembly  1100  in its fully closed configuration (e.g., during storage prior to use and/or after use). In alternative embodiments, the cutter assembly latch  1170  can be substantially permanently actuated such that the cutter assembly  1100  is locked in its fully closed configuration when the cutter assembly latch  1170  is engaged. In such embodiments, the cutter assembly latch  1170  can limit or prevent reuse of the cutter assembly  1100  and potential contamination resulting from such reuse. Further, in yet alternative embodiments, a cutter assembly can include multiple cutter assembly latches. For example, in such embodiments, the cutter assembly can include a first cutter assembly latch to temporarily lock the cutter assembly in its fully closed configuration (e.g., for safe and sanitary storage prior to use), and a second cutter assembly latch to substantially permanently lock the cutter assembly in its fully closed configuration (e.g., for safe and sanitary storage after use, and to prevent reuse). In some embodiments, the latch  1170  can self-engage in response to the force applied to transition the cutter assembly  1100  from its partially closed configuration to its fully closed configuration. Such self-engagement (e.g., via an interference fit) can provide for desirable locking of the cutter assembly, as discussed above, without requiring a user of the assembly from separately manipulating the latch. In yet alternative embodiments, the latch  1170  can require manipulation by a user to engage. 
         [0052]    Although the cutter assembly latch  1170  is shown and described as moving pivotally about a hinge, in alternative embodiments, a cutter assembly latch  1170  can move linearly with alternative mechanisms for connecting the moveable portions, e.g., the blade portion  2110  and the blade receptacle portion  2130 . 
         [0053]      FIGS. 3A and 3B  are schematic illustrations of the first clamp  1200  of the cutter clamp assembly  1000  of  FIGS. 1A-C  in open and closed configurations, respectively. For efficiency, only the first clamp  1200  will be discussed, however, it should be understood that the second clamp  1400  can be the same as or similar to the first clamp  1200 . As shown, the first clamp  1200  includes a first clamp upper jaw portion  1220  and a first clamp lower jaw portion  1210  rotationally coupled or hinged to the first clamp upper jaw portion  1220  via a first clamp hinge  1230 . 
         [0054]    The first clamp hinge  1230  is configured to promote relative angular movement or otherwise provide a pivot point between the first clamp upper jaw portion  1220  and the first clamp lower jaw portion  1210 . In this manner, as discussed above with respect to  FIGS. 1A-1C , transition of the cutter clamp assembly  1000  between configurations (e.g., from open configuration to partially closed configuration) can include the first clamp upper jaw portion  1220  and the first clamp lower jaw portion  1210  rotating relative to each other about the first clamp hinge  1230 . 
         [0055]    To clamp the organ O (e.g., an umbilical cord), the first clamp  1200  can be manipulated from a first, open configuration, to a second, closed configuration, as shown in sequence in  FIGS. 3A and 3B , respectively. With the first clamp  1200  disposed about the organ O (i.e., the organ O is positioned within the first clamp organ receiving zone  1251  defined between the first clamp upper jaw portion  1220  and the first clamp lower jaw portion  1210 ), the first clamp  1200  can be manipulated (e.g., by a manual force applied by a user to the first clamp upper jaw portion  1220  and/or the first clamp lower jaw portion  1210 ) to transition the first clamp  1200  from its open configuration ( FIG. 3A ) to its closed configuration ( FIG. 3B ). As shown schematically in  FIG. 3B , the organ O is clamped and deformed within the first clamp  1200  clamped zone  2252 . 
         [0056]    Further, as shown in  FIG. 3B , the first clamp  1200  includes a first clamp latch  1240 . When the first clamp  1200  is in its closed configuration ( FIG. 3B ), the first clamp latch  1240  can be actuated to lock or limit relative movement between the first clamp upper jaw portion  1220  and the first clamp lower jaw portion  1210 . In this manner, the first clamp  1200  can be secured in its closed configuration during storage prior to use and/or after use. Further, after use, i.e., when a portion of an organ is clamped by the first clamp  1200 , the first clamp latch  1240  can secure the organ in its clamped or deformed configuration (e.g., to promote sanitation and limit undesirable contamination of the organ or patient). The first clamp  1200  can be further manipulated to disengage the first clamp latch  1240  and/or transition the first clamp  1200  from its closed configuration to its open configuration. For example, in a procedure involving clamping an umbilical cord, the first clamp  1200  can clamp the umbilical cord to facilitate the cutting of the umbilical cord, and then the first clamp  1200  can be disengaged (moved from its closed configuration to its open configuration) or separated from the umbilical cord such that blood can be withdrawn from the umbilical cord, the first clamp  1200  can be repositioned and re-engaged, or simply removed from the cord. 
         [0057]    In some embodiments, the latch  1240  can self-engage in response to the force applied to transition the first clamp  1200  from its open configuration to its closed configuration. Such self-engagement (e.g., via an interference fit) can provide for desirable locking of the first clamp  1200 , as discussed above, without requiring a user of the cutter clamp assembly  1000  from separately manipulating the latch  1240 . In alternative embodiments, the latch may require manipulation of the latch by a user to engage the latch. In alternative embodiments, a latch can be substantially permanently engaged such that the latch locks the first clamp in its closed configuration. In such embodiments, the latch can limit or prevent reuse of the clamp and potential complications resulting from removal of the latch from the organ or patient. For example, in procedures in which umbilical cord blood collection is not performed, the latch can remain engaged such that the organ remains clamped by the latch. In such cases, in some instances, the latch can remain clamped about the organ at least until the organ is detached from the patient or when a trained healthcare personnel removes the clamp. 
         [0058]    Although the latch  1240  is shown and described as moving pivotally about a hinge, in alternative embodiments, a latch can move linearly with alternative mechanisms for connecting movable portions. 
         [0059]      FIG. 4  is a side-view schematic illustration of the cutter clamp assembly  1000  with the first clamp  1200  in its closed configuration and clamped about the organ O, and the cutter assembly  1100  in its partially closed configuration. With the organ O clamped by the first clamp  1200 , the organ O is positioned and arranged to be cut by the cutter assembly  1100 . Said another way, the cutter clamp assembly  1000  is configured such that, in use, the first clamp  1200  clamps the organ O such that the organ O is secured (e.g., prior to cutting or severing of the organ O) in a position to promote proper cutting of the organ O by the cutter assembly  1100 . 
         [0060]      FIG. 5  shows a schematic flow diagram of a method of cutting and clamping an elongate biological organ, according to an embodiment. The method  100  includes disposing a cutter clamp assembly (e.g., the cutter clamp assembly  1000  or any other cutter clamp assembly described herein) around an elongate biological organ (e.g., an umbilical cord), at  102 . 
         [0061]    The cutter clamp assembly can include a clamp with a lower jaw portion and an upper jaw portion coupled for relative movement between an open configuration defining an organ receiving zone therebetween and a closed configuration defining a clamped zone therebetween. The cutter clamp assembly can further include a cutter assembly having a blade portion and a blade receptacle portion coupled for relative movement between a first, open configuration, a second, partially closed configuration, and a third, fully closed configuration. The blade portion can include a blade projecting toward the receptacle portion, and the cutter assembly can define a cutting zone between the blade portion and the blade receptacle portion. In such a manner, the blade is clear of the cutting zone when the cutter assembly is disposed in the partially closed configuration and the blade is disposed across the cutting zone when the cutter assembly is disposed in the fully closed configuration. 
         [0062]    The cutter assembly can be releasably coupled to the clamp with the clamped zone of the clamp disposed laterally adjacent to the cutting zone of the cutter assembly. The cutter clamp assembly can further include a cutting timer mechanism configured such that relative movement of the blade portion and the blade receptacle portion between the open configuration and the partially closed configuration of the cutter assembly produces relative movement of the upper jaw portion and the lower jaw portion between the open configuration and the closed configuration of the clamp. The cutting timer mechanism can permit further relative movement of the blade portion and the blade receptacle portion between the partially closed configuration and the fully closed configuration of the cutter assembly without further relative movement of the upper jaw portion and the lower jaw portion of the clamp. 
         [0063]    At  102 , a first portion of the organ is disposed in the organ receiving zone of the clamp, and a second portion of the organ is disposed in the cutting zone of the cutter assembly (e.g., the cutting zone being laterally off-set from the organ receiving zone of the clamp). In this manner, a user can visually confirm proper positioning of the organ relative to the cutter clamp assembly prior to clamping or cutting of the organ, and the cutting and clamping of the organ can be temporally off-set. 
         [0064]    The method  100  further includes applying manual pressure to the blade portion and the blade receptacle portion of the cutter assembly to urge the cutter assembly from the open configuration to the partially closed configuration and thus to urge the clamp from the open configuration to the closed configuration and to clamp the first portion of the organ, at  104 . In this manner, the first portion of the organ can be clamped and secured such that the second portion of the organ is suitably arranged to be cut by the cutter assembly. For example, with the first portion of the organ being clamped when the second portion of the organ is cut, fluids within the organ are limited or prevented from undesirably flowing out of the organ through the opening caused by the cutting. Further, with the organ clamped prior to severance of the organ, potential contamination or infection of the organ or patient (e.g., newborn and/or mother) is limited. 
         [0065]    The method  100  further includes applying further manual pressure to the blade portion and the blade receptacle portion to urge the cutter assembly from the partially closed configuration to the fully closed configuration to cut or sever the second portion of the organ, at  106 . 
         [0066]    The method  100  further includes separating the clamp from the cutter assembly, with the clamp retained on the second portion of the organ, at  108 . In this manner, the second portion of the organ can remain clamped when separated from the cutter assembly. 
         [0067]    In some embodiments, a method can further include disengaging the clamp (e.g., causing the clamp to transition from its closed configuration to its open configuration) to reposition and reclamp the organ, withdrawn organ fluid or blood, or replace with a different clamp. 
         [0068]      FIGS. 6A and 6B  are perspective views of a cutter clamp assembly  2000  according to another embodiment, in an open configuration.  FIG. 6C  is a perspective view of the cutter clamp assembly  2000  in a fully closed configuration. The cutter clamp assembly  2000  includes a cutter assembly  2100  configured to cut an elongate biological organ, a first clamp  2200  configured to clamp a portion of the organ and removably coupled to the cutter assembly  2100  via a first clamp mount  2300 , and a second clamp  2400  configured to clamp a portion of the organ and removably coupled to the cutter assembly  2100  via a second clamp mount  2500 . 
         [0069]    The cutter assembly  2100  of the cutter clamp assembly  2000 , as illustrated in  FIG. 7A  in perspective view, in an open configuration, and in  FIG. 7B  in perspective view, in a closed configuration, includes a blade portion  2110  and a blade receptacle portion  2120  rotatably coupled to the blade portion  2110  via a cutter assembly hinge  2160 . The blade portion  2110 , as illustrated in  FIG. 8A  in perspective view, includes a blade  2112  configured to pierce, cut, and/or sever an elongate biological organ (not shown). The blade  2112  includes a blade tip  2113  configured to initiate a cut or pierce of an elongate biological organ. The blade portion  2110  further includes a blade portion grip  2116  ergonomically designed to facilitate gripping, actuating, or otherwise manipulating of the cutter clamp assembly  2000  by a user. As shown, the blade  2112  projects toward the blade receptacle portion  2122  of the cutter assembly  2100 . 
         [0070]    As shown in  FIGS. 6A-C , the blade receptacle portion  2120  (illustrated in  FIG. 8B  in perspective view) of the cutter assembly  2100  is rotationally coupled or hinged to the blade portion  2110  via the cutter assembly hinge  2160 . The cutter assembly hinge  2160  is configured to promote relative angular movement or otherwise provide a pivot point between the blade portion  2110  and the blade receptacle portion  2120 . In this manner, transition of the cutter assembly  2110  between configurations (e.g., open configuration, partially closed configuration, fully closed configuration) includes the blade portion  2110  and the blade receptacle portion  2120  rotating relative to each other about the cutter assembly hinge  2160 . 
         [0071]    The blade receptacle portion  2120  includes a blade receptacle  2122  configured to receive and at least partially surround the blade  2112  when the cutter assembly  2100  is in its partially closed configuration and/or its fully closed configuration. In this manner, the blade tip  2113  can be disposed within the blade receptacle  2122 , e.g., during storage of the cutter assembly  2100  or upon completion of a procedure, to limit or prevent undesirable or accidental cutting. The blade receptacle portion  2120  further includes a blade receptacle organ receiver  2124  configured to receive and/or guide a portion of the organ prior to cutting of the organ. The blade receptacle organ receiver  2124  provides repeatable and easy positioning of a portion of the organ in preparation for cutting of the organ by the blade  2112 , and provides suitable seating of the portion of the organ during the cutting of the same. For example, in use, a portion of an organ can be positioned across the blade receptacle organ receiver  2124  when the cutter assembly  2100  is in its open configuration. Further, the cutter assembly  2100  can be actuated such that the blade  2112  pierces the organ when the organ is disposed within the blade receptacle organ receiver  2124 . In this manner, the blade receptacle organ receiver  2124  at least temporarily contains the organ and provides a surface or counter-force to facilitate cutting or severing of the organ, and limits or prevents the organ from undesirably slipping or sliding away from the blade portion  2110  upon, e.g., upon contact with the blade  2112 . 
         [0072]    The blade receptacle portion  2120  further includes a blade receptacle portion grip  2126  ergonomically designed to facilitate gripping, actuating, or otherwise manipulating of the cutter clamp assembly  2000  by a user. In this manner, in use, a user can grip both the blade receptacle portion grip  2126  and the blade portion grip  2116  and apply forces (e.g., a user can squeeze both grips, with one or two hands) thereto to actuate the cutter clamp assembly  2100  to cut or sever an organ. 
         [0073]    The cutter assembly hinge  2160  of the cutter assembly  2100  includes a cutter hinge pin  2161  rotatably coupled to and disposed within a cutter hinge socket  2162 . The cutter assembly hinge  2160  further includes a cutter hinge stabilizer  2163  configured to stabilize or guide the cutter assembly  2100  between configurations. As shown, the cutter hinge stabilizer  2163  includes a cutter hinge stabilizer projection  2164  (projecting from the blade portion  2110 ) and a cutter hinge stabilizer receptacle (or guide)  2167  configured to receive the projection  2164  to provide stiffening or stabilization (e.g., limit undesirably lateral movement) between the blade portion  2110  and the blade receptacle portion  2120 . The cutter hinge stabilizer  2163  is further configured to inhibit an organ from extending or sliding into, or otherwise interfering with the hinge  2160  and impeding actuation of the cutter assembly  2100  (e.g., preventing the cutter assembly  2100  from fully transitioning from its open configuration to its partially closed configuration, and to its fully closed configuration) when the organ is clamped or in the process of being clamped or when the organ is cut or in the process of being cut. In this manner, interruption of the hinge  2160  during transitioning of the cutter assembly  2100  between configurations can be inhibited by the cutter hinge stabilizer  2163 . 
         [0074]    The cutter assembly hinge  2160  further includes a cutter hinge stop  2166  configured to limit or set a maximum angle defined between the blade portion  21110  and the blade receptacle portion  2120 . Similarly stated, the cutter hinge stop  2166  is configured to limit or prevent relative angular rotation between the blade portion  2110  and the blade receptacle portion  2120  beyond a threshold. As shown in  FIGS. 7B and 8B , the cutter hinge stop  2166  includes a projection extending from the blade receptacle portion  2120  that corresponds with and is operably coupled to the blade portion  2110 . In use, for example, as the cutter assembly  2100  is moved to the open configuration (e.g., from its partially closed configuration), relative movement of the blade portion  2110  relative to the blade receptacle portion  2120  is limited by contact between the projection of the cutter hinge stop  2166  and the corresponding surface of the blade portion  2110 . 
         [0075]    The cutter assembly  2100  further includes a cutter assembly latch  2170  configured to, when engaged, releasably retain the cutter assembly  2100  in its fully closed configuration. Said another way, the cutter assembly latch  2170  is configured to, when engaged, limit relative movement between the blade portion  2110  and the blade receptacle portion  2120  (e.g., during storage before or after use of the cutter clamp assembly  2000  in a procedure). The cutter assembly latch  2170  includes a cutter assembly latch projection  2172  extending from the blade portion  2110  and a cutter assembly latch receptacle  2174  defined by the blade receptacle portion  2120  and configured to receive, engage with and be releasably coupled to the cutter assembly latch projection  2172 . In use, when the cutter assembly is transitioned to its fully closed configuration (e.g., in response to a manual force provided by a user to the blade portion grip  2116  and the blade receptacle portion grip  2126 ), the cutter assembly latch projection  2172  is urged into the cutter assembly latch receptacle  2174  beyond a threshold (by way of a snap or interference fit) such that the cutter assembly latch  2170  engages. In this manner, the latch  2170  can self-engage, e.g., without requiring separate manipulation of the latch  2170  by a user. Such self-engagement promotes ease of use by allowing, for example, a single user to perform effectively and safely a cut/clamp procedure with the cutter assembly  2100 . 
         [0076]    In this embodiment, the cutter assembly latch  2170  can be engaged and disengaged by a user. For example, to disengage the cutter assembly latch  2170 , a user can manipulate the cutter assembly latch projection  2172  (e.g., press the latch projection from its biased position) to free or separate the latch projection  2172  from the latch receptacle  2174  such that the cutter assembly  2100  can be transitioned from its fully closed configuration to its partially closed or open configurations. In alternative embodiments, the cutter assembly latch  2170  can be substantially permanently engaged such that the cutter assembly latch  2170  locks the cutter assembly  2100  in its fully closed configuration when the cutter assembly latch  2170  is engaged. In such embodiments, the cutter assembly latch can limit or prevent reuse of the cutter assembly  2100  and potential contamination resulting from such reuse. 
         [0077]    Moreover, as discussed above, the cutter clamp assembly includes a first clamp  2200 , as illustrated in  FIGS. 9A-C  in perspective views, in an open configuration, and in  FIG. 9D  in perspective view, in a closed configuration. The first clamp  2200  is configured to clamp a portion of an elongate biological organ, and includes a first clamp upper jaw portion  2220  and a first clamp lower jaw portion  2210  rotationally coupled or hinged to the first clamp upper jaw portion  2220  via a first clamp hinge  2230 . The first clamp hinge  2230  is configured to promote relative angular movement or otherwise provide a pivot section or point between the first clamp upper jaw portion  2220  and the first clamp lower jaw portion  2210 . In this manner, the first clamp can transition between configurations (e.g., open and closed configurations) by the first clamp upper jaw portion  2220  and the first clamp lower jaw portion  2210  rotating relative to each other about the first clamp hinge  2230 . 
         [0078]    Similar to the discussion with respect to the first clamp  1200 , to clamp an organ, the first clamp  2200  can be manipulated from a first, open configuration, to a second, closed configuration. 
         [0079]    The first clamp hinge  2230  is configured to be biased to its open configuration. The first clamp hinge  2230  includes a first clamp hinge guard  2232  configured to facilitate clamping (i.e., movement of the first clamp hinge  2230  from its open, biased configuration, to its closed, unbiased configuration) of an organ by providing stabilization or stiffening of the first clamp upper jaw portion  2220 , the first clamp lower jaw portion  2210 , and the desired dynamics of the first clamp hinge  2230  as the first clamp  2200  transitions between configurations. The first clamp hinge guard  2232  is further configured to limit or prevent the organ from extending or sliding into, or otherwise interfering with the first clamp hinge  2230  (e.g., preventing the first clamp  2230  from fully transitioning to its closed position) when the organ is clamped or in the process of being clamped by the first clamp hinge  2230 . As shown, the first clamp hinge guard  2232  includes a first clamp hinge guard projection  2233  and a first clamp hinge guard receptacle  2234  configured to receive or slidably mate with the first clamp hinge guard projection  2233 , e.g., when the first clamp  2200  is in its closed configuration. In use, for example, as the first clamp  2200  is manipulated to clamp an organ, i.e., as the first clamp  2200  is transitioned from its open configuration to its closed configuration, the first clamp hinge guard projection  2233  will slide into the first clamp hinge guard receptacle  2234 . In this manner, in use, the first clamp hinge guard  2232  provides stiffening or stabilization (e.g., lateral stabilization) to promote proper clamping of an organ while limiting any undesirable counterforces by the organ from contributing to or causing incomplete clamping of the organ. Similarly stated, the first clamp hinge guard  2232  promotes continuous desirable alignment between the first clamp lower jaw  2210  and the first clamp upper jaw portion  2220  during clamping and cutting of the organ. 
         [0080]    The first clamp lower jaw  2210  of the first clamp  2200  includes a first clamp organ receiver  2214  configured to receive a portion of an organ to be clamped, and a first clamp lower jaw teeth  2216  configured to grip, hold or otherwise promote retainment of, the portion of the organ to be clamped. In this manner, in use, the first clamp organ receiver  2214  and the first clamp lower jaw teeth  2216  can promote proper positioning and retainment of the organ in preparation for and during clamping of the organ, and during cutting of the organ. The first clamp upper jaw portion  2220  includes a first clamp actuator arm  2224  having stiffening ribs  2225  to provide structural stiffening or support, and a first clamp upper jaw lever  2221  coupled to the actuator arm  2224  via a first clamp upper jaw lever support  2223 . The stiffening ribs  2225 , in use, for example, provide stabilizing support to the first clamp actuator arm  2224  to resist undesirable movement of the actuator arm  2224  in response to torque generated in part by the interaction of the first clamp  2200  and the cutting timing mechanism  2600 , as described in further detail herein. The upper jaw lever  2221 , collectively with the first clamp lower jaw  2210 , is configured to compress or clamp a portion of the organ when the portion of the organ is disposed in the first clamp organ receiver  2214 . 
         [0081]    The upper jaw lever  2221  includes first clamp upper jaw teeth  2222  configured to grip, hold or otherwise promote retainment of the portion of the organ to be clamped. Disposed between the first clamp upper jaw lever  2221  and the first clamp actuator arm  2224  is a first clamp upper jaw lever support  2223  (e.g., a fulcrum) configured to provide support about which the upper jaw lever  2221  can pivot or move, e.g., in response to contact with the organ, relative to the first clamp actuator arm  2224 , the first clamp hinge  2230  and the first clamp lower jaw  2210 . 
         [0082]    As discussed in further detail herein, during a clamp and cut procedure, predictable and repeatable timing of the clamping relative to the cutting is important to the effectiveness, safety and overall success of such a procedure. Elongate biological organs, however, vary in size, stiffness and other properties, across various patients. Accordingly, the upper jaw lever  2221 , the upper jaw lever support  2223  and the actuator arm  2224  are collectively configured to promote predictable and repeatable clamp and cut timing for a wide range of organs having various properties and characteristics. For example, in use, as the first clamp  2200  is actuated (i.e., transitioned from its open configuration to its closed configuration) and the upper jaw lever  2221  and the lower jaw  2210  come into contact with a portion of the organ, the allowance of relative movement between the first clamp upper jaw lever  2221  and the first clamp actuator arm  2224  allows for suitable clamping of the organ without undesirably affecting the timing of the clamping relative to the subsequent cutting or severing of the organ, as will be discussed in further detail herein with respect to the cutter timer mechanism  2600 . Further, such relative movement allows for use of a single-sized clamp for clamping of organs having various sizes, e.g., small diameter organs and large diameter organs, without having to design and manufacture clamps of various sizes to facilitate various sized organs. 
         [0083]    The first clamp  2200  further includes a first clamp latch  2240  having a first clamp latch first portion  2242  and a first clamp latch second portion  2244  configured to removably engage with or couple to the first portion  2242 . When engaged, the first clamp  2200  is removably locked in its closed configuration. Similarly stated, the first clamp latch  2240 , when engaged, is configured to limit relative movement between the first clamp lower jaw  2210  and the first clamp upper jaw portion  2220  (e.g., the first clamp actuator arm  2224  of the upper jaw portion  2220 ). In this manner, the first clamp  2200  can be secured in its closed configuration during storage prior to use and/or after use. Further, after use, i.e., when a portion of an organ is clamped by the first clamp  2200 , the first clamp latch  2240  can secure the organ in its clamped or deformed configuration (e.g., to promote sanitation and limit undesirable contamination of the organ or patient). The first clamp  2200  can be further manipulated to disengage the first clamp latch  2240  and/or transition the first clamp  2200  from its closed configuration to its open configuration. For example, in a procedure involved clamping an umbilical cord, the first clamp  2200  can clamp the umbilical cord to facilitate the cutting of the umbilical cord, and then the first clamp  2200  can be disengaged (moved from its closed configuration to its open configuration) or separated from the umbilical cord such that blood can be withdrawn from the umbilical cord. 
         [0084]    In some embodiments, the latch  2240  can self-engage in response to the force applied to transition the first clamp  2200  from its open configuration to its closed configuration. Such self-engagement (e.g., via an interference fit) can provide for desirable locking of the first clamp  2200 , as discussed above, without requiring a user of the cutter clamp assembly  2000  from separately manipulating the latch  2240 . Such self-engagement can further promote ease of use by allowing, for example, a single user to perform effectively and safely a cut/clamp procedure with the cutter assembly  2100 . In alternative embodiments, the latch may require manipulation of the latch by a user to engage the latch. 
         [0085]    In yet alternative embodiments, the latch can be substantially permanently engaged such that the latch locks the first clamp in its closed configuration when the latch is engaged or actuated. In such embodiments, the latch can limit or prevent reuse of the clamp and potential complications resulting from removal of the latch from the organ or patient. For example, in procedures in which umbilical cord blood collection is not performed, the latch can remain engaged such that the organ remains clamped by the latch. In such cases, in some instances, the latch can remain clamped about the organ at least until the organ is detached from the patient or when a trained healthcare personnel removes the clamp. 
         [0086]    As discussed above and as illustrated, for example, in  FIGS. 6A-6C , the first clamp  2200  is removably coupled to the cutter assembly  2100  via the first clamp mount  2300 . The first clamp mount  2300  is configured to operably and removably couple the first clamp  2200  to the cutter assembly  2100  such that, as discussed further herein, the first clamp  2200  can be actuated when coupled to the cutter assembly  2100 , and decoupled or separated from the cutter assembly  2100  when the first clamp  2200  is in its closed configuration and the cutter assembly  2100  has transitioned from its open configuration its fully closed configuration. In this manner, in use, the first clamp  2200  can separate from the cutter assembly  2100  and maintain clamping of a portion of the organ when the organ has been cut or severed by the cutter assembly  2100 . 
         [0087]    The first clamp mount  2300  includes a collection of corresponding features of the cutter assembly  2100  and the first clamp  2200 . Referring to the cutter assembly  2100 , the first clamp mount  2300  includes a first clamp mount cutter portion  2130  of the cutter assembly  2100 , defining a first post  2131  and a second post  2132  extending from the blade receptacle portion  2120 . Referring to the first clamp  2200 , the first clamp lower jaw portion  2210  of the first clamp  2200  includes a first clamp mount clamp portion  2212  configured to releasably mate with the first clamp mount cutter portion  2130  of the cutter assembly  2100 . As shown, for example in  FIG. 6A , the first clamp mount clamp portion  2212  of the first clamp lower jaw  2210  defines receptacles or sockets configured to receive and slidably and removably mate with the first post  2131  and the second post  2132  of the first clamp mount cutter portion  2130 . 
         [0088]    As discussed above, in use, a force applied at and to the cutter assembly, e.g., the blade receptacle portion grip  2126  and the blade portion grip  2116 , can actuate the cutter clamp assembly  2000  such that relative movement of the blade portion  2110  and the blade receptacle portion  2120  of the cutter assembly  2100  between its open configuration and its partially closed configuration produces relative movement of the first clamp upper jaw portion  2220  and the first clamp lower jaw portion  2210  of the first clamp  2200  between its open configuration and its closed configuration. To facilitate such suitable timing and transfer of forces to cause transitions between such configurations, the cutter clamp assembly  2000  includes a cutting timer mechanism  2600 . 
         [0089]    The cutting timer mechanism  2600  includes a first clamp cutting timer shoulder  2226  of the first clamp  2200  extending laterally from the first clamp actuator arm  2224 . The first clamp cutting timer shoulder  2226  defines a first clamp cutting timer receptacle  2227  configured to slidably couple to or mate with a corresponding first projection  2152  of a cutting timer blade portion  2150  (of the cutting timer mechanism  2600 ) of the cutter assembly  2100 . As shown, for example in  FIG. 7 , the first projection  2152  of the cutting timer blade portion  2150  extends from the blade  2112  of the cutter assembly  2100 , and is configured to slide within or be guided by the first clamp cutting timer receptacle  2227  when the first clamp  2200  is coupled to the cutter assembly  2100  and the cutter assembly  2100  transitions from its open configuration to its partially closed configuration. 
         [0090]    Moreover, with the first clamp  2200  in its closed configuration, as the cutter assembly  2100  transitions from its partially closed configuration to its fully closed configuration, the first projection  2152  slides towards and beyond an edge of the first clamp cutting timer receptacle  2227 . With the first projection  2152  separated from the first clamp cutting timer receptacle  2227 , further relative movement of the cutter assembly  2100  (from its partially closed configurations towards its fully closed configuration) includes the first projection  2152  of the cutting timer blade portion  2150  interfere with and push the first clamp upper jaw portion  2220  such that the first clamp mount cutter portion  2130  of the cutter assembly  2100  is decoupled or separated from the first clamp mount clamp portion  2212 , and the first clamp  2200  is decoupled or separated from the cutter assembly  2100 . 
         [0091]    As discussed herein, the cutter clamp assembly  2000  further includes a second clamp  2400  configured to clamp a portion of an elongate biological organ and removably coupled to the cutter assembly  2100  via the second clamp mount  2500 . The second clamp  2400  is the same as and functions the same as the first clamp  2200 , but is a mirror image of the first clamp  2200 . Similarly, the second clamp mount  2400  is the same as and functions the same as the first clamp mount  2300 . For example, the second clamp  2400  includes a second clamp upper jaw portion  2420  and a second clamp lower jaw portion  2410  rotationally coupled or hinged to the second clamp upper jaw portion  2320  via second clamp hinge  2420 . 
         [0092]    Similar to the discussion with respect to the first clamp  1200  and the first clamp  2200 , to clamp an organ, the second clamp  2400  can be manipulated from a first, open configuration, to a second, closed configuration. With the second clamp  2400  disposed about an organ (i.e., the organ is positioned within a second clamp organ receiving zone  2451  defined between the second clamp upper jaw portion  2420  and the second clamp lower jaw portion  2410 ), the second clamp  2400  can be manipulated (e.g., by a manual force applied by a user to the second clamp upper jaw portion  2420  and/or the second clamp lower jaw portion  2410 ) to transition the second clamp  2400  from its open configuration to its closed configuration. 
         [0093]    The second clamp hinge  2430  is configured to be biased to its open configuration. The second clamp hinge  2430  includes a second clamp hinge guard  2432  configured to facilitate clamping (i.e., movement of the second clamp hinge  2430  from its open, biased configuration, to its closed, unbiased configuration) of an organ by providing stabilization or stiffening of the second clamp upper jaw portion  2420 , the second clamp lower jaw portion  2410 , and the desired dynamics of the second clamp hinge  2430  as the second clamp  2400  transitions between configurations. The second clamp hinge guard  2432  is further configured to limit or prevent the organ from extending or sliding into, or otherwise interfering with the second clamp hinge  2430  (e.g., preventing the second clamp  2430  from fully transitioning to its closed position) when the organ is clamped or in the process of being clamped by the second clamp hinge  2430 . As shown, the second clamp hinge guard  2432  includes a second clamp hinge guard projection  2433  and a second clamp hinge guard receptacle  2434  configured to receive or slidably mate with the second clamp hinge guard projection  2433 , e.g., when the second clamp  2400  is in its closed configuration. In use, for example, as the second clamp  2400  is manipulated to clamp an organ, i.e., as the second clamp  2400  is transitioned from its open configuration to its closed configuration, the second clamp hinge guard projection  2433  will slide into the second clamp hinge guard receptacle  2434 . In this manner, in use, the second clamp hinge guard  2432  provides stiffing or stabilization (e.g., lateral stabilization) to promote proper clamping of an organ while limiting any undesirable counterforces by the organ from contributing to or causing incomplete clamping of the organ. Similarly stated, the second clamp hinge guard  2432  promotes continuous desirable alignment between the second clamp lower jaw  2410  and the second clamp upper jaw portion  2420  during clamping and cutting of the organ. 
         [0094]    The second clamp lower jaw  2410  of the second clamp  2400  includes a second clamp organ receiver  2414  configured to receive a portion of an organ to be clamped, and a second clamp lower jaw teeth  2416  configured to grip, hold or otherwise promote retainment of the portion of the organ to be clamped. In this manner, in use, the second clamp organ receiver  2414  and the second clamp lower jaw teeth  2416  can promote proper positioning and retainment of the organ in preparation for and during clamping of the organ, and during cutting of the organ. 
         [0095]    The second clamp upper jaw portion  2420  includes a second clamp actuator arm  2424  having stiffening ribs  2425  to provide structural stiffening or support, and a second clamp upper jaw lever  2421  coupled to the actuator arm  2424  via a second clamp upper jaw lever support  2423 . The stiffening ribs  2425 , in use, for example, provide stabilizing support to the second clamp actuator arm  2424  to resist undesirable movement of the actuator arm  2424  in response to torque generated in part by the interaction of the second clamp  2400  and the cutting timing mechanism  2600 , as described in further detail herein. The upper jaw lever  2421 , collectively with the second clamp lower jaw  2410 , is configured to compress or clamp a portion of the organ when the portion of the organ is disposed in the second clamp organ receiver  2414 . 
         [0096]    The upper jaw lever  2421  includes second clamp upper jaw teeth  2422  configured to grip, hold or otherwise promote retainment of the portion of the organ to be clamped. Disposed between the second clamp upper jaw lever  2421  and the second clamp actuator arm  2424  is a second clamp upper jaw lever support  2423  (e.g., a fulcrum) configured to provide support about which the upper jaw lever  2421  can pivot or move, e.g., in response to contact with the organ, relative to the second clamp actuator arm  2424 , the second clamp hinge  2430  and the second clamp lower jaw  2410 . 
         [0097]    As discussed in further detail herein, during a clamp and cut procedure, predictable and repeatable timing of the clamping relative to the cutting is important to the effectiveness, safety and overall success of such a procedure. Elongate biological organs, however, vary in size, stiffness and other properties, across various patients. Accordingly, the upper jaw lever  2421 , the upper jaw lever support  2423  and the actuator arm  2424  are collectively configured to promote predictable and repeatable clamp and cut timing for a wide range of organs having various properties and characteristics. For example, in use, as the second clamp  2400  is actuated (i.e., transitioned from its open configuration to its closed configuration) and the upper jaw lever  2421  and the lower jaw  2410  come into contact with a portion of the organ, the allowance of relative movement between the second clamp upper jaw lever  2421  and the second clamp actuator arm  2424  allows for suitable clamping of the organ without undesirably affecting the timing of the clamping relative to the subsequent cutting or severing of the organ, as will be discussed in further detail herein with respect to the cutter timer mechanism  2600 . Further, such relative movement allows for use of a single-sized clamp for clamping of organs having various sizes, e.g., small diameter organs and large diameter organs, without having to design and manufacture clamps of various sizes to facilitate various sized organs. 
         [0098]    The second clamp  2400  further includes a second clamp latch  2440  having a second clamp latch second portion  2442  and a second clamp latch second portion  2444  configured to removably engage with or couple to the second portion  2442 . When engaged, the second clamp  2400  is removably locked in its closed configuration. Similarly stated, the second clamp latch  2440 , when engaged, is configured to limit relative movement between the second clamp lower jaw  2410  and the second clamp upper jaw portion  2420  (e.g., the second clamp actuator arm  2424  of the upper jaw portion  2420 ). In this manner, the second clamp  2400  can be secured in its closed configuration during storage prior to use and/or after use. Further, after use, i.e., when a portion of an organ is clamped by the second clamp  2400 , the second clamp latch  2440  can secure the organ in its clamped or deformed configuration (e.g., to promote sanitation and limit undesirable contamination of the organ or patient). The second clamp  2400  can be further manipulated to disengage the second clamp latch  2440  and/or transition the second clamp  2400  from its closed configuration to its open configuration. For example, in a procedure involved clamping an umbilical cord, the second clamp  2400  can clamp the umbilical cord to facilitate the cutting of the umbilical cord, and then the second clamp  2400  can be disengaged (moved from its closed configuration to its open configuration) or separated from the umbilical cord such that blood can be withdrawn from the umbilical cord. 
         [0099]    In some embodiments, the latch  2440  can self-engage in response to the force applied to transition the second clamp  2400  from its open configuration to its closed configuration. Such self-engagement (e.g., via an interference fit) can provide for desirable locking of the second clamp  2400 , as discussed above, without requiring a user of the cutter clamp assembly  2000  from separately manipulating the latch  2440 . Such self-engagement can further promote ease of use by allowing, for example, a single user to perform effectively and safely a cut/clamp procedure with the cutter assembly  2100 . In alternative embodiments, the latch may require manipulation of the latch by a user to engage the latch. 
         [0100]    In yet alternative embodiments, the latch can be substantially permanently engaged such that the latch locks the second clamp in its closed configuration when the latch is engaged or actuated. In such embodiments, the latch can limit or prevent reuse of the clamp and potential complications resulting from removal of the latch from the organ or patient. For example, in procedures in which umbilical cord blood collection is not performed, the latch can remain engaged such that the organ remains clamped by the latch. In such cases, in some instances, the latch can remain clamped about the organ at least until the organ is detached from the patient or when a trained healthcare personnel removes the clamp. 
         [0101]    As discussed above and as illustrated, for example, in  FIGS. 6A-6C , the second clamp  2400  is removably coupled to the cutter assembly  2100  via the second clamp mount  2300 . The second clamp mount  2300  is configured to operably and removably couple the second clamp  2400  to the cutter assembly  2100  such that, as discussed further herein, the second clamp  2400  can be actuated when coupled to the cutter assembly  2100 , and decoupled or separated from the cutter assembly  2100  when the second clamp  2400  is in its closed configuration and the cutter assembly  2100  has transitioned from its open configuration its fully closed configuration. In this manner, in use, the second clamp  2400  can separate from the cutter assembly  2100  and maintain clamping of a portion of the organ when the organ has been cut or severed by the cutter assembly  2100 . 
         [0102]    The second clamp mount  2300  includes a collection of corresponding features of the cutter assembly  2100  and the second clamp  2400 . Referring to the cutter assembly  2100 , the second clamp mount  2300  includes a second clamp mount cutter portion  2140  of the cutter assembly  2100 , defining a first post  2141  and a second post  2142  extending from the blade receptacle portion  2120 . Referring to the second clamp  2400 , the second clamp lower jaw portion  2410  of the second clamp  2400  includes a second clamp mount clamp portion  2412  configured to releasably mate with the second clamp mount cutter portion  2140  of the cutter assembly  2100 . As shown, for example in  FIG. 6A , the second clamp mount clamp portion  2412  of the second clamp lower jaw  2410  defines receptacles or sockets configured to receive and slidably and removably mate with the second post  2131  and the second post  2132  of the second clamp mount cutter portion  2140 . 
         [0103]    As discussed above, in use, a force applied at and to the cutter assembly, e.g., the blade receptacle portion grip  2126  and the blade portion grip  2116 , can actuate the cutter clamp assembly  2000  such that relative movement of the blade portion  2110  and the blade receptacle portion  2120  of the cutter assembly  2100  between its open configuration and its partially closed configuration produces relative movement of the second clamp upper jaw portion  2420  and the second clamp lower jaw portion  2410  of the second clamp  2400  between its open configuration and its closed configuration. To facilitate such suitable timing and transfer of forces to cause transitions between such configurations, the cutter clamp assembly  2000  includes a cutting timer mechanism  2600 . 
         [0104]    The cutting timer mechanism  2600  includes a second clamp cutting timer shoulder  2426  of the second clamp  2400  extending laterally from the second clamp actuator arm  2424 . The second clamp cutting timer shoulder  2426  defines a second clamp cutting timer receptacle  2427  configured to slidably couple to or mate with a corresponding second projection  2154  of a cutting timer blade portion  2150  (of the cutting timer mechanism  2600 ) of the cutter assembly  2100 . As shown, for example in  FIG. 7 , the second projection  2154  of the cutting timer blade portion  2150  extends from the blade  2112  of the cutter assembly  2100 , and is configured to slide within or be guided by the second clamp cutting timer receptacle  2427  when the second clamp  2400  is coupled to the cutter assembly  2100  and the cutter assembly  2100  transitions from its open configuration to its partially closed configuration. 
         [0105]    Moreover, with the second clamp  2400  in its closed configuration, as the cutter assembly  2100  transitions from its partially closed configuration to its fully closed configuration, the second projection  2154  slides towards and beyond an edge of the second clamp cutting timer receptacle  2427 . With the second projection  2154  separated from the second clamp cutting timer receptacle  2427 , further relative movement of the cutter assembly  2100  (from its partially closed configurations towards its fully closed configuration) includes the second projection  2154  of the cutting timer blade portion  2150  interfere with and push the second clamp upper jaw portion  2420  such that the second clamp mount cutter portion  2140  of the cutter assembly  2100  is decoupled or separated from the second clamp mount clamp portion  2412 , and the second clamp  2400  is decoupled or separated from the cutter assembly  2100 . 
         [0106]    In use, as illustrated in  FIGS. 10A-10C , during an umbilical cord procedure, for example, with the cutter assembly  2100  coupled to the first clamp  2200  via the first clamp mount  2300  and the cutter assembly  2100  coupled to the second clamp  2400  via the second clamp mount  2500 , the umbilical cord can be disposed across the cutter clamp assembly  2000  in preparation for clamping and cutting of the umbilical cord (see e.g.,  FIG. 10A ). More specifically, a first portion “Fp” of the umbilical cord can be disposed across the first clamp organ receiver  2214  and within the first clamp organ receiving zone  2251 . A second portion “Sp” of the umbilical cord can be disposed across the blade receptacle portion organ receiver  2124  and within the cutting zone  2180 . A third portion “Tp” of the umbilical cord can be disposed across the second clamp organ receiver  2414  and within the second clamp organ receiving zone  2451 . In this manner, as illustrated in  FIG. 10A , the second portion of the umbilical cord (i.e., the portion of the umbilical cord to be cut) is disposed between the first and third portions of the umbilical cord (i.e., the portions of the umbilical cord to be clamped). 
         [0107]    Due in part to the symmetry on either side of the blade  2112 , a user can approach the umbilical cord from various sides and angles. In some instances, for example, the first portion of the umbilical cord can be on the placenta-side of the umbilical cord while the third portion of the umbilical cord is on the newborn-side of the umbilical cord. In other instances, for example, the first portion of the umbilical cord can be on the newborn-side and the third portion of the umbilical cord can be on the placenta side. Such a configuration promotes repeatable approaches regardless of the particular user, and similarly limits potential for mistakes (e.g., by an untrained user). 
         [0108]    With the umbilical cord suitably positioned relative to the cutter clamp assembly  2000 , pressure (e.g., manual pressure from a user) can be applied to the blade portion  2110  of the cutter assembly  2100  and the blade receptacle portion  2120  of the cutter assembly  2100  to transition the cutter assembly  2100  from its open configuration to its partially closed configuration and thus to transition (1) the first clamp  2200  from its open configuration to its closed configuration and to clamp the first portion of the umbilical cord between the first clamp lower jaw  2210  and the first clamp upper jaw lever  2221 , and (2) the second clamp  2400  from its open configuration to its closed configuration and to clamp the third portion of the umbilical cord between the second clamp lower jaw  2410  and the second clamp upper jaw lever  2421 . 
         [0109]    As discussed herein, the pressure applied to transition the cutter assembly  2100  to its partially closed configuration causes the first projection  2152  of the cutting timer blade portion  2150  to slide along the first clamp cutting timer receptacle  2227  of the first clamp cutting timer shoulder  2226  such that the pressure is transferred from the first projection to the first clamp  2200  to urge the first clamp  2200  to its closed configuration. Further, the first clamp latch  2240  engages when the first clamp  2200  is in its closed configuration and the first portion of the organ is clamped by the first clamp  2200 . 
         [0110]    Similarly, the pressure applied to transition the cutter assembly  2100  to its partially closed configuration causes the second projection  2252  of the cutting timer blade portion  2150  to slide along the second clamp cutting timer receptacle  2427  of the second clamp cutting timer shoulder  2426  such that the pressure is transferred from the second projection to the second clamp  2400  to urge the second clamp  2400  to its closed configuration. Further, the second clamp latch  2440  engages when the second clamp  2400  is in its closed configuration and the third portion of the organ is clamped by the second clamp  2400 . 
         [0111]    In some instances, with the cutter assembly  2100  in its partially closed configuration, the blade tip  2113  can pierce and at least partially cut the second portion of the organ such that the blade portion  2112  is in communication with contents (e.g., blood) of the organ. With the first clamp  2200  and the second clamp  2400  in close proximity to the blade  2110  (i.e., on either side of the blade  2110 ), content splatter in response to the cutting and clamping is limited or at least partially contained in the cutter clamp assembly  2000 , thereby promoting sanitation of the area surrounding the procedure. Said another way, the first clamp  2200  and the second clamp  2400 , in some instances, can intercept or block content from splattering from the cutter clamp assembly  2000 . 
         [0112]    Further, with the first clamp  2200  and the second clamp  2400  and their closed configurations, further pressure applied to transition the cutter assembly  2100  towards its fully closed configuration causes the first clamp  2200  and the second clamp  2400  to separate from the cutter assembly  2100 , with the first clamp  2200  retained on the first portion of the organ and the second clamp  2400  retained on the third portion of the organ. 
         [0113]    Further pressure (e.g., manual pressure by a user) can be applied to the blade portion  2110  of the cutter assembly  2100  and the blade receptacle portion  2120  of the cutter assembly  2100  to transition the cutter assembly  2100  from its partially closed configuration to its fully closed configuration (see e.g.,  FIG. 10B ), and to cut or sever the second portion of the organ. Upon the further pressure, the cutter assembly latch  2170  engages when the cutter assembly  2100  is in its fully closed configuration such that further relative movement between the blade portion  2110  and the blade receptacle portion  2120  is limited. 
         [0114]    As illustrated in  FIG. 10C , upon severance of the umbilical cord, the first clamp  2200  can be separated from the cutter assembly  2100  while remaining clamped to a portion of the umbilical cord. 
         [0115]    In an alternative embodiment, a cutter clamp assembly can be configured similar to or the same as the cutter clamp assembly  2000 , except that a cutter hinge of the cutter assembly includes a ratchet mechanism configured to allow movement of the cutter assembly from its open configuration to its partially closed configuration, and further to its fully closed configuration, but to limit movement in a reversed direction, i.e., from the fully closed configuration to the partially closed configuration, and from the partially closed configuration to the open configuration. In this manner, when a cutter clamp assembly having a ratchet mechanism is used to clamp and cut an elongate biological organ, the ratchet mechanism can limit or prevent opening or removal of the cutter assembly prior to complete actuation or complete or suitable severing of the organ. In some embodiments, the ratchet mechanism can substantially permanently secure the cutter assembly in its closed configuration. 
         [0116]      FIG. 11  illustrates a cutter clamp assembly  3000  having a cutter hinge ratchet  3165 . The cutter clamp assembly  3000  can be constructed and function similar to any of the cutter clamp assemblies described herein, e.g., the cutter clamp assembly  2000 . Thus, some details regarding the cutter clamp assembly  3000  are not described below. It should be understood that for features and functions not specifically discussed, those features and functions can be the same as or similar to any of the cutter clamp assemblies described herein. 
         [0117]    As shown in  FIG. 11 , the cutter clamp assembly  3000  includes a cutter hinge ratchet  3165 . The cutter hinge ratchet  3165  is configured to allow movement of the cutter hinge stabilizer projection  3164  (projecting from the blade portion  3110 ) relative to the cutter hinge stabilizer receptacle (or guide)  3167  when the projection  3164  is disposed within the stabilizer receptacle  3167  and the cutter assembly  3000  is moving from an open configuration to a partially closed configuration or from a partially closed configuration to a fully closed configuration. Further, the cutter hinge ratchet  3165  is configured to limit or prevent movement of the cutter hinge stabilizer projection  3164  from the cutter hinge stabilizer receptacle  3167  when the projection  3164  is disposed within the stabilizing receptacle  3167 . Similarly stated, the cutter hinge ratchet  3165  limits or prevents the cutter assembly  3100  from transitioning from a closed configuration to a partially closed configuration or from the partially closed configuration to an open configuration. In this manner, when the cutter clamp assembly  3000  is used to clamp and cut an elongate biological organ, the ratchet mechanism can limit or prevent opening or removal of the cutter assembly  3000  prior to complete actuation or complete or suitable severing of the organ. Further, the cutter hinge ratchet  3165  can limit or prevent reuse of the cutter assembly (and the cutter clamp assembly), thereby limiting insanitation and infections due to such reuse. 
         [0118]    In an alternative embodiment, a cutter clamp assembly can be configured similar to or the same as the cutter clamp assembly  3000 , except that the cutter assembly excludes a cutter assembly latch. In such embodiments, the cutter hinge ratchet can be configured to lock the cutter assembly in its fully closed configuration (e.g., after the cutter assembly is used in a procedure) such that the cutter assembly cannot transition from its fully closed configuration (e.g., from its fully closed configuration to its partially closed configuration or its open configuration). 
         [0119]      FIG. 12  illustrates a cutter clamp assembly  4000  having a cutter hinge ratchet  3165  and excluding a cutter assembly latch  2170 . The cutter clamp assembly  4000  can be constructed and function similar to any of the cutter clamp assemblies described herein, e.g., the cutter clamp assembly  1000 ,  2000 , and/or  3000 . Thus, some details regarding the cutter clamp assembly  4000  are not described below. It should be understood that for features and functions not specifically discussed, those features and functions can be the same as or similar to any of the cutter clamp assemblies described herein. 
         [0120]    As shown in  FIG. 12 , the cutter clamp assembly  4000  includes a cutter hinge ratchet  4165 . The cutter hinge ratchet  4165  is configured to allow movement of the cutter hinge stabilizer projection  4165  (projecting from the blade portion  4110 ) relative to the cutter hinge stabilizer receptacle (or guide)  4167  when the projection  4164  is disposed within the stabilizer receptacle  4167  and the cutter assembly  4000  is moving from an open configuration to a partially closed configuration or from a partially closed configuration to a fully closed configuration. Further, the cutter hinge ratchet  4165  is configured to limit or prevent movement of the cutter hinge stabilizer projection  4164  from the cutter hinge stabilizer receptacle  4167  when the projection  3164  is disposed within the stabilizing receptacle  4167 . Similarly stated, the cutter hinge ratchet  4165  limits or prevents the cutter assembly  4100  from transitioning from a closed configuration to a partially closed configuration or from the partially closed configuration to an open configuration. In this manner, when the cutter clamp assembly  4000  is used to clamp and cut an elongate biological organ, the ratchet mechanism can limit or prevent opening or removal of the cutter assembly  4000  prior to complete actuation or complete or suitable severing of the organ. Further, the cutter hinge ratchet  4165  can limit or prevent reuse of the cutter assembly (and the cutter clamp assembly), thereby limiting insanitation and infections due to such reuse. 
         [0121]    In alternative embodiments, cutter clamp assemblies can be constructed and function similar to or the same as any of the cutter clamp assemblies described above, but can include a blade portion grip and/or a blade receptacle portion grip having a greater width over a greater extent of each side of the cutter assembly, and/or can define finger indentations for improved comfort and more secured grip, thereby promoting effective, repeatable (i.e., consistent use across various users), and easy actuation of the cutter clamp assembly by a user. In some embodiments, a blade portion grip and/or a blade receptacle portion grip can include one or more eye loops (e.g., allowing a user to slide his/her finger therethrough) to promote more stability, grip, and a better transfer of force from the user to the cutter clamp assembly. In some embodiments, a blade portion grip and/or a blade receptacle portion grip can extend beyond one or more edges of the blade portion and/or the blade receptacle portion, thereby providing more grip surface area for a user, and/or providing improved torque (e.g., due to a greater distance of the applied force by the user from the cutter assembly hinge) when a user applies a manual force to the cutter clamp assembly. 
         [0122]    Optionally, an antibacterial agent, such as Chlorhexidine, can be packaged with a cutter-clamp assembly (e.g., any of the cutter-clamp assemblies described herein) so that the antibacterial agent can be applied to the organ (e.g., the umbilical cord) stump after delivery. As another option, the packaged antibacterial agent, such as Chlorhexidine, may be laid and/or stabilized across the cutting zone of the cutter assembly so that the package is opened and automatically dispersed on the organ during clamping and cutting of the organ. Said another way, actuation of one or more clamps, or actuation of the cutter assembly, can cause the antibacterial agent (e.g., by piercing a package containing the antibacterial agent) to be released at or near the cutting or clamping zones, thereby limiting complications resulting of insanitation or infections. 
         [0123]    While various embodiments have been described above, it should be understood that they have been presented in a way of example only, and not limitation. Where schematics and/or embodiments described above indicate certain components arranged in certain orientations or positions, the arrangement of components may be modified. While the embodiments have been particularly shown and described, it will be understood that various changes in form and details may be made. 
         [0124]    Although various embodiments have been described as having particular features and/or combinations of components, other embodiments are possible having a combination of any features and/or components from any of the embodiments discussed above.