Abstract:
Provided is an automatic analysis device that enables a reagent to be reliably loaded in and loaded out within a stipulated amount of time, even during analysis and without stopping the analysis, and that enables a reagent to be exchanged without causing a long wait for the operator. Provided is the automatic analysis device that comprises the following: a reagent cooling box that cools and holds a plurality of reagent containers, and that accommodates therein a reagent holder for movably holding the reagent containers which are inside the reagent cooling box and a reagent loader for loading the reagent containers into and out of the reagent cooling box by moving in a vertical direction with respect to the reagent cooling box; a reagent cooling box cover that covers the upper surface of the reagent cooling box and that has an opening through which the reagent loader can pass; an instruction means that provides instructions for the movement of the reagent loader; and a control device that includes, within the time of one cycle, a first time slot in which an operation for analysis is carried out and a second time slot in which an operation for the loading in or out of the reagent containers is carried out, and that executes control so that the reagent loader is not moved if the driving of the reagent loader was instructed by the instruction means in the second time slot.

Description:
TECHNICAL FIELD 
       [0001]    The present invention relates to an automated analyzer for performing qualitative/qualitative analysis of a biological sample such as blood or urine. 
       BACKGROUND ART 
       [0002]    An automated analyzer adds a reagent specifically reacting with a specific component contained in a biological sample such as blood or urine, causes the reagent to react with the specific component, and measures an absorbance and an amount of luminescence of a reaction liquid, thereby performing quantitative/qualitative analysis. 
         [0003]    Generally, the automated analyzer includes a reagent container depository that can store a plurality of reagents corresponding to a plurality of analysis items so as to enable the analysis to be performed with respect to the plurality of analysis items. An analyzer management operator mounts reagents necessary for analysis of a day in the reagent container depository in advance. However, if shortage of reagents occurs during the analysis, the operator interrupts the analysis to replace the reagent. 
         [0004]    Meanwhile, the number of analysis items for the automated analyzer has recently increased, and the number of automated analyzers that can mount many reagent containers by downsizing each reagent container so as to serve as analyzers compatible with analysis having many analysis items has increased. If the number of reagent containers mounted in the analyzer increases, it is highly likely that the shortage of reagents occurs, compared with a conventional analyzer. To address the problem, there is known an automated analyzer including a mechanism that can automatically add a reagent container to a reagent container depository (see, for example, Patent Document 1). 
       CITATION LIST 
     Patent Literature 
       [0005]    Patent Document 1: JP Patent Publication 2005-37171 A 
       SUMMARY OF INVENTION 
     Technical Problem 
       [0006]    In the automated analyzer described in Patent Document 1, the reagent can be automatically added during the analysis. However, it is necessary to temporarily stop the reagent container depository (reagent cooler) in order to displace the reagent from a reagent container temporary depository to the reagent cooler, which requires the analysis to be temporarily interrupted or requires a user to wait until the analysis is over. Furthermore, even if sample dispensing is interrupted, the reagent cooler is not stopped until completion of dispensing of all reagents to already dispensed samples (to complete the analysis of the already dispensed samples for avoiding waste of the samples). For the period of time, the user is forced to wait. 
         [0007]    As a process capability of the automated analyzer is enhanced and space saving is achieved, the consumption of reagents per analysis time increases. In addition, the reagent cooler and a reagent container displacement mechanism incessantly operate during the analysis. Owing to this, temporarily stopping the reagent cooler and the reagent container displacement mechanism due to frequent reagent replacement causes reduction of an analysis throughput. Needs grows to automatically replace the reagent to reduce operator&#39;s waiting time as much as possible without interrupting the analysis. 
         [0008]    An object of the present invention is to provide an automated analyzer that can load and unload a reagent within a specified time even during analysis without interrupting the analysis and replace the reagent without keeping an operator waiting for a long period of time. 
       Solution to Problem 
       [0009]    To address the problem, the present invention is characterized in that an automated analyzer includes: a reagent holder holding a plurality of reagent containers so as to be movable; a reagent cooler for cooling the reagent containers held on the reagent holder; a reagent loader moving vertically with respect to the reagent cooler in order to load and unload the reagent container to and from the reagent cooler; instruction means for instructing displacement of the reagent loader; and a control section for exercising control so as not to vertically displace the reagent loader when the instruction means instructs driving the reagent loader in a second period, wherein one cycle time includes a first period for implementing operation for analysis and the second period for implementing operation for loading/unloading the reagent container. 
       Advantageous Effects of Invention 
       [0010]    According to the present invention, it is possible to implement loading/unloading of a reagent container while suppressing user waiting time within certain time even during analysis, and to improve user work efficiency. Objects other than the abovementioned object, configurations, and advantages will be readily apparent from the description of embodiments given below. 
     
    
     
       BRIEF DESCRIPTION OF DRAWINGS 
         [0011]      FIG. 1  is a configuration diagram of an automated analyzer according to an embodiment of the present invention. 
           [0012]      FIG. 2  is an explanatory diagram of a configuration of a peripheral part of a reagent cooler used in the automated analyzer according to the embodiment of the present invention. 
           [0013]      FIG. 3  is a configuration diagram of a reagent container used in the automated analyzer according to the embodiment of the present invention. 
           [0014]      FIG. 4  is an explanatory diagram of functions of a control section used in the automated analyzer according to the embodiment of the present invention. 
           [0015]      FIG. 5  is a flowchart diagram illustrating logic for creating a load reagent request at a time of planning to load a reagent container in the automated analyzer according to the embodiment of the present invention. 
           [0016]      FIG. 6  is a flowchart diagram illustrating logic for creating an unload reagent request at a time of planning to unload the reagent container in the automated analyzer according to the embodiment of the present invention. 
           [0017]      FIG. 7  is a time chart diagram illustrating timing of mechanism operation implemented by a reagent cooler, a reagent loader, and a reagent container displacement mechanism in the automated analyzer according to the embodiment of the present invention. 
           [0018]      FIG. 8  is a flowchart diagram illustrating logic for determining switchover between operation for loading the reagent container and operation for unloading operation of the reagent container in the automated analyzer according to the embodiment of the present invention. 
           [0019]      FIG. 9  is an explanatory diagram of a reagent loadable/unloadable confirmation screen used in the automated analyzer according to the embodiment of the present invention. 
           [0020]      FIG. 10  is a flowchart diagram illustrating process implemented when an operator operates a reagent loader switch in the automated analyzer according to the embodiment of the present invention. 
       
    
    
     DESCRIPTION OF EMBODIMENTS 
       [0021]    A configuration and operation of an automated analyzer  100  according to an embodiment of the present invention will be described hereinafter. The automated analyzer  100  is intended to allow one system to implement different types of analysis, for example, biochemical analysis and immune analysis. It is noted that the same constituent elements are denoted by the same reference characters. 
         [0022]    First, an overall configuration of the automated analyzer  100  according to the embodiment of the present invention will be described with reference to  FIG. 1 .  FIG. 1  is a configuration diagram of the automated analyzer  100  according to the embodiment of the present invention. The automated analyzer  100  includes a rack transport line  3  transporting a sample container rack  2 , a reagent cooler  5  a reagent loader  6 , an incubator disk  9 , a sample dispensing mechanism  10 , a reagent dispensing mechanism  11 , a reaction container/sample dispensing chip storage section  12 , a replacement/supplementation reaction container/sample dispensing chip storage section  13 , a reaction container stirring mechanism  14 , a disposal hole  15 , a transport mechanism  16 , nozzles  17   a ,  17   b , detection units  18   a ,  18   b , and a control section  19 . It is noted that an automated analyzer may have another configuration if the configuration can realize the present invention and enables a plurality of reagent containers to be held. 
         [0023]    The sample container rack  2  stores a plurality of sample containers  1  each storing a biological sample (hereinafter, referred to as “sample”) such as blood or urine. The rack transport line  3  transports the sample container rack  2 . 
         [0024]    The reagent cooler  5  (reagent container holding section) is covered with a reagent cooler cover  7 , and stores a plurality of reagent containers  4  storing various reagents used for reagent analysis in a condition of keeping the reagent containers  4  at a constant temperature. In the present embodiment, the reagent cooler  5  is configured with an outer circumferential holder  51  that has positions  53  therein for holding the reagent containers  4  on a circumference of a circle and can be driven to rotate and an inner circumferential holder  52  that has positions for fixedly holding the reagent containers  4 . Furthermore, the reagent loader  6  is provided adjacent to the inner circumferential holder  52  as described later, and a motor vertically driving the reagent loader  6  is provided. Moreover, a reagent container opening mechanism (not shown) for opening the reagent containers  4  is provided in the reagent cooler  5 , whereby it is possible to open/close a lid of each reagent container  4  in the reagent cooler  5  and to suppress degradation of the reagents. It is noted that the reagent cooler  5  is not limited to a disk type but may be a serial type of arranging the reagent containers  4  in one or more lines. 
         [0025]    The reagent loader  6  is provided in an inner circumferential portion of the reagent cooler  5 . In addition, a reagent container displacement mechanism  20  for displacing the reagent container  4  between the reagent cooler  5  and the reagent loader  6  is provided near the reagent cooler  5  and the reagent loader  6  in a movable manner. When one reagent container  4  is loaded, the reagent container displacement mechanism  20  transports the loading target reagent container  4  from the reagent loader  6  to the outer circumferential holder  51 . When one reagent container  4  is unloaded, the reagent container displacement mechanism  20  transports the reagent container  4  from the outer circumferential holder  51  to the reagent loader  6 . Detailed configurations of the reagent loader  6  and the reagent container displacement mechanism  20  will be described later with reference to  FIG. 2 . 
         [0026]    The incubator disk  9  has a plurality of container holding holes that can store a plurality of reaction containers  8  for mixing the sample with reagents on a circumference of a circle, and is driven to intermittently rotate so as to locate each reaction container  8  at a predetermined position as analysis progresses. In a portion in which the incubator disk  9  is stopped, process necessary for steps such as sample or reagent dispensing, stirring, and analysis steps is implemented. 
         [0027]    The sample dispensing mechanism  10  includes an arm section driven to rotate and vertically driven, and a nozzle section sucking and discharging the sample. A sample dispensing chip  10   a  can be detachably attached to a tip end of the nozzle section. The sample dispensing mechanism  10  moves downward the nozzle section with respect to the sample container  1  transported to a sample dispensing position by the rack transport line  3  to suck a predetermined amount of the sample, and rotates the arm section to discharge the sample to one reaction container  8  located at a predetermined position on the incubator disk  9 . 
         [0028]    The reagent dispensing mechanism  11  includes a nozzle section sucking and discharging the reagents. The reagent dispensing mechanism  11  discharges, through a reagent cooler cover opening  7   a  provided in the reagent cooler cover  7  to the reaction container  8  located at the predetermined position on the incubator disk  9 , predetermined amounts of the reagents sucked from the reagent container  4  by operation for horizontal driving, perpendicular driving, and suction/discharging. 
         [0029]    The reaction container stirring mechanism  14  stirs a reaction liquid stored in the reaction container  8  taken out from the incubator disk  9 . 
         [0030]    The reaction container/sample dispensing chip storage section  13  stores a plurality of unused reaction containers  8  and a plurality of unused sample dispensing chips  10   a . The reaction container/sample dispensing chip storage section  12  is prepared for replacing or refilling the reaction container/sample dispensing chip storage section  13 . When the sample dispensing chip  10   a  is attached to the nozzle tip end of the sample dispensing mechanism  10  and the sample in the sample container is sucked, the used sample dispensing chip  10   a  is disposed of from the disposal hole  15 . The used reaction container  8  completed with analysis is similarly disposed of from the exhaust hole. 
         [0031]    The transport mechanism  16  includes a gripper section gripping the sample dispensing chip  10   a  and the reaction container  8  stored in the reaction container/sample dispensing chip storage section  13 . The transport mechanism  16  also includes a drive section transporting the gripper mechanism along XYZ axes. Specifically, the transport mechanism  16  is provided to be movable in X-axis, Y-axis, and Z-axis directions (not shown). The transport mechanism  16  transports the reaction container  8  stored in the reaction container/sample dispensing chip storage section  13  to the incubator disk  9 , disposes of the used reaction container  8  to the disposal hole  15 , and transports the unused sample dispensing chip  10   a  to a chip attachment position  16   a.    
         [0032]    The nozzles  17   a  and  17   b  suck the reaction liquids mixed in the reaction containers  8  of the incubator disk  9 . The nozzles  17   a  and  17   b  feed the reaction liquids to the respective detection units  18   a  and  18   b  by being driven to rotate or vertically driven. The detection units  18   a  and  18   b  perform detection process on the reaction liquids sucked and fed by the nozzles  17   a  and  17   b  to detect a specific component. 
         [0033]    An operator operates a reagent loader switch  21  to notify the automated analyzer  100  of start of loading and unloading of the reagent container  4 . Detailed process implemented when the reagent loader switch  21  is depressed will be described later with reference to  FIG. 8 . 
         [0034]    The control section  19  exercises control over the entire operation of the automated analyzer  100 . The control section  19  includes a controller  19   a , a display section  19   b , an input section  19   c , and a storage section  19   d . A detailed configuration of the control section  19  will be described later with reference to  FIG. 4 . 
         [0035]    A configuration of a peripheral part of the reagent cooler  5  (reagent container holding section) used in the automated analyzer  100  according to the embodiment of the present invention will next be described with referring to  FIG. 2 .  FIG. 2  is an explanatory diagram of a configuration of the reagent cooler  5  used in the automated analyzer  100  according to the embodiment of the present invention. 
         [0036]    The reagent cooler  5  includes the outer circumferential holder  51  that holds a plurality of reagent containers  4  on the circumference of a circle and that can be driven to rotate, the inner circumferential holder  52  that fixedly holds the reagent containers  4 . The reagent cooler  5  also includes the reagent loader  6  that is provided on an inner circumferential side of the outer circumferential holder  51  (near a center of the reagent cooler  5 ) and that can be driven vertically. Preferably, the inner circumferential holder  52  and the reagent loader  6  are provided on the same circumference of a circle. 
         [0037]    The reagent loader  6  has a plurality of positions into which the reagent containers  4  are inserted, and can vertically move the reagent container  4  inserted into each position and can transfer the reagent container  4  inside or outside of the reagent cooler  5 . While the reagent loader  6  shown in  FIG. 2  is configured such that five positions are provided and up to five reagent containers  4  can be installed, the number of the installable reagent containers  4  is not limited to five. 
         [0038]    Furthermore, a reader (not shown) is provided near the reagent loader  6  to read out an individual identification label  4   d  (RFID tag in the present embodiment) adhering to a wall surface of each reagent container  4  and to transmit identification information thereon to the controller  19   a  of the control section  19 . It is noted that a barcode label or the like may be used as the individual identification label  4   d  for the reagent container  4 . The identification information recorded in the individual identification label  4   d  includes a reagent identification number (identification code) for identifying reagents stored in the reagent container  4 , inspection item names corresponding to the stored reagents, reagent identification codes, a lot number, a sequence number, and the like. 
         [0039]    The reagent container displacement mechanism  20  radially displaces each reagent container  4  among the outer circumferential holder  51 , the inner circumferential holder, and the reagent loader  6 . The reagent container displacement mechanism  20  can rotationally move about the center of the reagent cooler  5  that serves as an axis, and access all positions and all positions in the outer circumferential holder  51 , the inner circumferential holder  52 , and the reagent loader within the reagent cooler  5 . While the reagent cooler  5  includes one reagent container displacement mechanism  20  in the present embodiment, the reagent cooler  5  may include a plurality of reagent container displacement mechanisms  20 . Further, while the reagent container displacement mechanism  20  is configured to be independent of the reagent cooler  5  and the reagent loader  6  in the present embodiment, the reagent container displacement mechanism  20  may be a mechanism configured to be included in the reagent cooler  5  or in the reagent loader  6 . 
         [0040]    Analysis operation implemented by each of the outer circumferential holder  51 , the reagent loader, and the reagent container displacement mechanism  20  of the reagent cooler  5  will next be described in accordance with analysis steps. 
         [0041]    First, to dispense a first reagent, the outer circumferential holder  51  rotates to displace the target reagent container  4  to a position at which the reagent dispensing mechanism  11  can access the reagent container  4  (displacement  1  for reagent dispensing). The reagent dispensing mechanism  11  accesses the reagent container  4  installed in the reagent cooler  5 , sucks the reagent, and then dispenses the first reagent to the reaction container  8  installed in the incubator disk  9 . 
         [0042]    When sample dispensing is over and reaction time specified for every analysis item passes, a second reagent is dispensed to the reaction container  8  on the incubator disk  9 . In a case of implementing immune analysis, the second reagent contains magnetic particles; therefore, it is necessary to implement stirring process for dispersing the magnetic particles in the liquid before dispensing. In the automated analyzer  100  according to the present embodiment, a stirring mechanism for stirring the magnetic particles is provided near the inner circumferential holder  52  of the reagent cooler  5 . Owing to this, before and after stirring of the magnetic particles, the reagent container displacement mechanism  20  displaces the reagent container  4  between the inner circumferential holder  52  and the outer circumferential holder  51 . At timing of stirring the magnetic particles, the outer circumferential holder  51  rotates and the reagent container displacement mechanism  20  implements operation for reagent container displacement to displace the target reagent container toward the inner circumferential holder  52 , thereby displacing the reagent container  4  to a magnetic particle stirring position at which the magnetic particle stirring mechanism can access the reagent container  4 . 
         [0043]    The magnetic particle stirring mechanism accesses the reagent container  4  displaced to the magnetic particle stirring position to stir the magnetic particles. To displace the reagent container  4  completed with stirring of the magnetic particles from the inner circumferential holder  52  to the outer circumferential holder  51 , the reagent cooler  5  is driven to rotate to displace a vacant position to an access position of the reagent container displacement mechanism  20  (displacement after stirring of magnetic particles). To dispense the second reagent after the reagent container is displaced to the outer circumferential holder  51 , the reagent cooler  5  rotates to displace the target reagent container  4  to a position at which the reagent dispensing mechanism  11  can access the target reagent container  4  (displacement  2  for reagent dispensing). The reagent dispensing mechanism  11  accesses the reaction container  4  installed in the reagent cooler  5 , sucks the reagent, and then dispenses the second reagent to the reaction container  8  installed on the incubator disk  9 . In this way, the reagent cooler  5  and the reagent container displacement mechanism  20  operate, thereby performing a series of reagent dispensing operation in the analysis. 
         [0044]    In the automated analyzer  100  according to the present embodiment, only one reagent container displacement mechanism  20  is provided from the viewpoint of space saving, and the one reagent container displacement mechanism  20  implements both the displacement of the reagent container for access to the magnetic particle stirring mechanism and the displacement of the reagent container to/from the reagent loader  6  for reagent loading/unloading. Owing to this, at timing at which the reagent container displacement mechanism  20  is implementing the displacement of the reagent container for the analysis, the reagent container cannot be displaced to the reagent loader  6  for loading/unloading. It applies to the outer circumferential holder  51 . To implement the loading/unloading of the reagent container without delay in analysis operation during implementation of the analysis, timing at which the analysis operation is not implemented is allocated to the reagent container loading/unloading by the outer circumferential holder  51  and the reagent container displacement mechanism. 
         [0045]    At the reagent container loading/unloading timing, the outer circumferential holder  51  is driven to rotate to locate one position to be close to the reagent loader  6 . Subsequently, the reagent container displacement mechanism is caused to operate. In a case of reagent loading, the reagent container displacement mechanism displaces the reagent container from the position of the reagent loader  6  to a vacant position of the outer circumferential holder  51 . In a case of reagent unloading, the reagent container displacement mechanism displaces the reagent container from the position on the outer circumferential holder  51  to a vacant position on the reagent loader  6 . 
         [0046]    A configuration of the reagent container  4  used in the automated analyzer  100  according to the embodiment of the present invention will next be described with reference to  FIG. 3 .  FIG. 3  is a configuration diagram of the reagent container  4  used in the automated analyzer  100  according to the embodiment of the present invention. 
         [0047]    Each reagent container  4  is configured with small bottles  4   a  to  4   c  storing a plurality of types of (three types in the present embodiment) reagents. One reagent container  4  (that is, the small bottles  4   a  to  4   c ) stores a set of reagents necessary for one analysis item. Examples of the reagents stored in the bottles  4   a  to  4   c  of the reagent container  4  include a luminous label reagent containing a luminous label and a magnetic particle reagent containing magnetic particles. 
         [0048]    Functions of the control section  19  used in the automated analyzer  100  according to the embodiment of the present invention will next be described with reference to  FIG. 4 .  FIG. 4  is a functional block diagram of the control section  19  used in the automated analyzer  100  according to the embodiment of the present invention. The control section  19  exercises control over the entire operation of the automated analyzer  100 . 
         [0049]    The control section  19  exercises control over the loading/unloading of the reagent container  4  and sample analysis process on the basis of a preset program or an operator&#39;s command input by the input section  19   c  or the like. The control section  19  includes the controller  19   a  that exercises control over operation of the automated analyzer  100  and process for an analysis result, the input section  19   c  to which information/setting about the sample and analysis items is input and which transmits the information to the controller  19   a  as needed, the display section  19   b  that displays an analysis-related setting input screen and the analysis result, and the storage section  19   d  that stores the analysis-related setting, the information on the sample, the reagents, and the like, the analysis result, and the like. 
         [0050]    The storage section  19   d  includes a reagent loading/unloading information storage section  119   f , a mounted reagent information storage section  119   g , a reagent position information storage section  119   h , and a mechanism control information storage section  119   i.    
         [0051]    The mounted reagent information storage section  119   g  is a functional block that stores reagent use history information and identification information on the reagent container  4  to be associated with each other. Here, the reagent use history information is reagent information on the reagents stored in a plurality of reagent containers  4  mounted in the reagent cooler  5  or installed in the reagent loader  6  and includes at least information about a reagent condition indicating whether each reagent can be used. In other words, the mounted reagent information storage section  119   g  stores the identification information on the reagent container and the information about the reagent condition to be associated with each other. 
         [0052]    A reading mechanism such as an RFID reader or a barcode reader is provided in a moving route of the reagent loader. The reading mechanism can read out the individual identification information on the reagent container  4  displaced by the reagent loader. When the reading mechanism reads out the identification information and the information about the reagent condition from the individual identification information  4   d  for the reagent container loaded into the reagent cooler  5 , the individual identification information is transmitted to the storage section  19   d  via the controller  19   a  and stored in the mounted reagent information storage section  119   g . Conversely, when the reading mechanism reads out the individual identification information for the reagent container unloaded from the reagent cooler  5 , the individual identification information and the associated reagent use history information are deleted from the mounted reagent information storage section  119   g . It is noted that the information about the reagent condition may be read out from the individual identification information  4   d , or may be retrieved and obtained from information stored in the storage section on the basis of the identification information read out from the individual identification information  4   d.    
         [0053]    The reagent loading/unloading information storage section  119   f  is a functional block that stores information about a displace reagent request on the reagent container  4  and the identification information on the reagent container  4  to be associated with each other. Here, the information about the displace reagent request is information on a plurality of reagent containers  4  installed in the reagent cooler  5  or the reagent loader  6 . The reagent displacement request information includes at least information about a load reagent request and information about an unload reagent request. The reagent loading/unloading information storage section  119   f  stores the information about the load reagent request and the information about the unload reagent request of which the reagent loading/unloading information storage section  119   f  is notified by a reagent loading/unloading management section  119   a  to be described later. Furthermore, the input section  19   c  is notified of a reagent unloading instruction from the operator via means such as a dedicated screen or a switch, and the reagent unloading instruction is stored in the reagent loading/unloading information storage section  119   f  as the information about the unload reagent request. 
         [0054]    When the reagent container displacement mechanism  20  operates to displace the to-be-loaded reagent container  4  from the reagent loader  6  to the outer circumferential holder  51 , the information about the load reagent request on the reagent container  4  is deleted from the reagent loading/unloading information storage section  119   f . Further, when the reagent container  4  to be unloaded from the reagent cooler  5  is displaced from the outer circumferential holder  51  to the reagent loader  6 , the information about the unload reagent request on the reagent container  4  is deleted from the reagent loading/unloading information storage section  119   f.    
         [0055]    The reagent position information storage section  119   h  is a functional block that stores information about a reagent position condition. The information about the reagent position condition is information as to whether the reagent container is held in a position on the outer circumferential holder  51 , the inner circumferential holder  52 , or the reagent loader. 
         [0056]    The mechanism control information storage section  119   i  is a functional block that stores information about mechanism control to be described later. 
         [0057]    The controller  19   a  includes the reagent loading/unloading management section  119   a , a reagent condition management section  119   b , a reagent position management section  119   c , a mechanism operation control section  119   d , and an analyzer condition management section  119   e.    
         [0058]    The reagent loading/unloading management section  119   a  is a functional block that manages the loading/unloading of each reagent container  4  in the reagent cooler  5  (including the reagent loader  6 ) on the basis of a reagent condition of the reagent container  4  and a vacant condition of each position. Specifically, the reagent loading/unloading management section  119   a  plans the reagent displacement request information (reagent load request information and reagent unload request information) according to the reagent condition information acquired from the mounted reagent information storage section  119   g  and to the reagent position condition information acquired from the reagent position information storage section  119   h . The reagent loading/unloading management section  119   a  stores the created information about the displace reagent request in the reagent loading/unloading information storage section  119   f  as the information about the load reagent request or the information about the unload reagent request. The reagent loading/unloading management section  119   a  manages a progress of each step when the reagent container displacement mechanism  20  or the reagent loader  6  implements the reagent container loading/unloading. Planning of the reagent loading/unloading will be described later in detail. 
         [0059]    Here, the information about the load reagent request includes at least information regarding which one of loading target reagent containers held at each position is loaded to which one of positions on the reagent loader  6 . The information about the unload reagent request includes at least information regarding which one of reagent containers held at each position is unloaded to which positions of the outer circumferential holder  51 . 
         [0060]    The reagent condition management section  119   b  is a functional block that provides the information about a reagent condition indicating a latest condition of the reagent container  4  in the reagent cooler  5  (including the reagent loader  6 ). When the reagent loading/unloading management section  119   a  instructs the reagent condition management section  119   b  to obtain the information about the reagent condition, the reagent condition management section  119   b  obtains the mounted reagent information from the mounted reagent information storage section  119   g . The reagent condition management section  119   b  updates the information about the reagent condition on the basis of the obtained mounted reagent information. The reagent condition management section  119   b  notifies the reagent loading/unloading management section  119   a  of the updated information about the reagent condition. 
         [0061]    The reagent position condition management section  119   c  is a functional block that provides the information about the reagent position condition indicating a condition of each position in the reagent cooler  5  (including the reagent loader  6 ). When the reagent loading/unloading management section  119   a  instructs the reagent position management section  119   c  to obtain the information about the reagent position condition, the reagent position management section  119   c  obtains, from the reagent position information storage section  119   h , the information (information about the reagent position) as to whether the reagent container is installed at any position of the outer circumferential holder  51  and the inner circumferential holder  52  or any position of the reagent loader  6 . The reagent position management section  119   c  updates the information about the reagent position condition on the basis of the obtained information the reagent position, and notifies the reagent loading/unloading management section  119   a  of the updated information about the reagent position condition. 
         [0062]    The mechanism operation control section  119   d  is a functional block that controls the outer circumferential holder  51 , the reagent loader  6 , and the reagent container displacement mechanism  20  to operate. Specifically, the mechanism operation control section  119   d  plans to drive the outer circumferential holder  51  to rotate, vertically drive the reagent loader  6 , and cause the reagent container displacement mechanism  20  to operate on the basis of the information about the displace reagent request obtained from the reagent loading/unloading information storage section  119   f  and information about the analyzer condition obtained from the analyzer condition management section  119   e  to be described later. Created mechanism control information is stored in the mechanism control information storage section  119   i . The mechanism operation control section  119   d  extracts the mechanism control information from the mechanism control information storage section  119   i  at timing of implementing controlling the outer circumferential holder  51 , the reagent loader  6 , and the reagent container displacement mechanism  20  to operate, and instructs the mechanisms to be controlled on the basis of the mechanism control information. 
         [0063]    The analyzer condition management section  119   e  is a functional block that provides the information about the analyzer condition. The analyzer condition management section  119   e  manages information as to whether analysis is being implemented as the information about the analyzer condition to be provided. 
         [0064]    The input section  19   c  includes a load/unload reagent request input section  119   j  that enables the operator to instruct the automated analyzer  100  to load/unload the reagent container. While the input section is not particularly limited to a specific example, it is possible to instruct the automated analyzer  100  to unload the reagent designated by the operator via, for example, depression of the loader switch arranged near the reagent loader  6  or the dedicated screen. 
         [0065]    The display section  19   b  can display a reagent loadable/unloadable display section  119   k  on the screen. The display section will be described later in detail. 
         [0066]    Planning and implementation of the loading and unloading of the reagent container  4  in the automated analyzer  100  according to the embodiment of the present invention will next be described with reference to  FIGS. 5 to 7 . 
         [0067]    A method of creating, by the reagent loading/unloading management section  119   a , the information about the load reagent request for loading the reagent container on the reagent loader  6  to the outer circumferential holder  51  will be described with reference to  FIG. 5 . 
         [0068]    First, when the reader detects presence of the to-be-loaded reagent container by moving downward the reagent loader  6  in a condition in which the reagent container  4  is installed on the reagent loader  6 , process is started (Step S 50 ). The reagent loading/unloading management section  119   a  obtains the already created information about the load reagent request from the reagent loading/unloading information storage section  119   f  (Step S 51 ), and confirms whether there is information about a load reagent request on the reagent container (Step S 52 ). When the information about the load reagent request is already stored for the loading target reagent container  4  (Step S 52 ; YES), the process is ended. 
         [0069]    When the information about the load reagent request is not stored in Step S 20  (Step S 52 ; NO), the reagent loading/unloading management section  119   a  obtains the information about the reagent condition on the target reagent container  4  from the mounted reagent information storage section  119   g  (Step S 53 ). The information about the reagent condition at a time of loading can be classified into information about three conditions, i.e., (1) a loadable condition in which the target reagent container  4  can be loaded to the device, (2) an unloadable condition in which the target reagent container cannot be loaded to the device, and (3) a temporary unloadable condition in which the target reagent container cannot be temporarily loaded to the device. It is confirmed whether the reagent condition of the target reagent container  4  is the loadable condition out of these reagent conditions. When the obtained information about the reagent condition on the reagent container  4  does not indicate the loadable condition (Step S 54 ; NO), it is not appropriate to load the reagent container  4  to the outer circumferential holder  51 . Therefore, the process is ended and the reagent container  4  is left mounted on the reagent loader  6 . 
         [0070]    It is noted that (2) the unloadable condition means the reagent condition in which the reagent container  4  is continuously unusable in the future as well since the reagent has expired or none of the reagents is left. (3) The temporarily unloadable condition means the reagent condition in which the reagent is unusable for a resolvable reason such as presence of bubbles on a liquid surface or temporary inability to read out the individual identification information. (1) The loadable condition means the reagent condition other than the above conditions. 
         [0071]    When the reagent condition information on the reagent container  4  indicates the loadable condition in Step S 40  (Step S 54 ; YES), the reagent loading/unloading management section  119   a  obtains the information about the reagent position condition from the reagent position information storage section  119   h . The reagent loading/unloading management section  119   a  determines which position of the outer circumferential holder  51  the target reagent container  4  is loaded to on the basis of the information about the reagent condition and the information about the reagent position condition, and creates the information about the load reagent request (Step S 55 ). The reagent loading/unloading management section  119   a  then instructs the created information about the load reagent request to be stored in the reagent loading/unloading information storage section  119   f  (Step S 56 ), thereby ending the process (Step S 57 ). 
         [0072]    A series of steps described above is implemented to all the reagent containers  4  installed at the positions of the reagent loader  6  per cycle. Thus, when the reagent container to be loaded is installed on the reagent loader  6 , it is possible to create a plan to load a new reagent container from a position of the reagent loader  6  to the vacant position of the reagent cooler  5  irrespective of whether the analysis is being implemented. 
         [0073]    Regarding a method of determining a reagent loading order and installation positions of the reagent containers  4  when the loading target reagent containers  4  are loaded to the positions in the reagent cooler  5 , the reagent containers  4  are loaded from the reagent loader  6  to vacant positions of the outer circumferential holder  51  in an ascending order of position numbers on the reagent loader  6  such that the reagent container held at the position having a lowest position number is loaded first when the reagent containers  4  are loaded from the reagent loader  6  to the reagent cooler  5 . While it is described that the order of loading the reagent containers  4  to the reagent cooler  5  is the ascending order in the embodiment of the present invention, the loading order may be set by another logic such as a descending order of the position numbers. Further, as for the method of determining the positions on the outer circumferential holder  51  that is a loading destination, the first reagent container  4  is loaded to the position at the vacant position having a lowest position number out of the vacant positions of the outer circumferential holder  51 , that is, the vacant positions of the reagent cooler  5  are used in an ascending order of the position numbers. While it is described that as for the method of determining the positions on the reagent cooler  5  as the loading destination, the order is the ascending order of the position numbers on the reagent cooler  5  in the embodiment of the present invention, the order is not limited to the ascending order but may be a descending order of the position numbers on the reagent cooler  5  or the like. 
         [0074]    A method of creating, by the reagent loading/unloading management section  119   a , the information about the unload reagent request for unloading the reagent container on the outer circumferential holder  51  to the reagent loader  6  will next be described with reference to  FIG. 6 . 
         [0075]    When the operator instructs the automated analyzer  100  to unload the reagent container or when the controller  19  detects occurrence of the reagent container to be unloaded due to a change in the information about the reagent condition, process is started (Step S 60 ). The reagent loading/unloading management section  119   a  obtains the information about the unload reagent request from the reagent loading/unloading information storage section  119   f  (Step S 61 ), and confirms whether there is information about an unload reagent request included therein (Step S 62 ). When the information about the unload reagent request for the unloading target reagent container  4  is already stored (Step S 62 ; YES), the process is ended. 
         [0076]    When the information about the unload reagent request is not stored in Step S 120  (Step S 62 ; NO), the reagent loading/unloading management section  119   a  obtains the information about the reagent condition on the reagent container  4  from the mounted reagent information storage section  119   g  (Step S 63 ). The information about the reagent condition at a time of unloading can be classified into information about three conditions, i.e., (1) a usable condition in which the reagent container  4  is usable for analysis, (2) an unusable condition in which the reagent container  4  is unusable for the analysis, and (3) a temporarily unusable condition in which the reagent container  4  is temporarily unusable for the analysis. It is confirmed whether the reagent condition of the target reagent container  4  is the usable condition out of these reagent conditions. When the obtained information about the reagent condition on the reagent container  4  indicates the usable condition (step S 64 ; YES), the process is ended. It is noted that the conditions (1) to (3) are almost the same as contents of the information about the reagent condition identified by the loading condition shown in  FIG. 5 . 
         [0077]    When the information about the reagent condition on the reagent container  4  does not indicate the usable condition in Step S 140  (Step S 64 ; NO), then the reagent loading/unloading management section  119   a  obtains the information about the reagent position condition from the reagent position information storage section  119   h , and creates information about an unload reagent request on the reagent container  4  on the basis of the information about the reagent condition and the information about the reagent position condition (Step S 65 ). The reagent loading/unloading management section  119   a  instructs the created information about the unload reagent request to be stored in the reagent loading/unloading information storage section  119   f  (Step S 66 ), thereby ending the step (Step S 67 ). 
         [0078]    A series of steps described above is implemented to all the reagent containers  4  installed in the reagent cooler  5  whenever reagent dispensing process is implemented to the reagent containers held in the reagent cooler  5 . It is thereby possible to create an implementation plan for displacing the loading target reagent containers from the positions of the outer circumferential holder  51  to the vacant positions of the reagent loader  6  irrespective of whether the analysis is being implemented. 
         [0079]    An order of displacing the reagent containers  4  from the outer circumferential holder  51  of the reagent cooler  5  to the reagent loader  6  is determined by a factor for unloading the reagent containers  4  and position information on the outer circumferential holder  51 . As the factor for unloading the reagent container  4 , three types of factors are present, that is, an unloading factor by operator&#39;s designation, an unloading factor because the reagent container  4  becomes temporarily unusable, and an unloading factor because the reagent container  4  becomes unusable. Among these factors, the reagent container unloaded by operator&#39;s designation is highest in an order of priority, followed by the reagent container unloaded because the reagent container becomes temporarily unusable and the reagent container because the reagent container becomes unusable. If the factor for unloading the reagent container  4  is the same among a plurality of reagent containers  4 , the reagent container at the position having the lowest position number on the reagent cooler  5  where the reagent containers  4  are installed is the highest in the order of priority. 
         [0080]    As logic for determining the positions on the displacement destination when the reagent containers  4  are displaced from the outer circumferential holder  51  to the positions on the reagent loader  6 , the first reagent container  4  is displaced to the position at which no reagent container  4  is installed and which has the lowest position number among all the positions. The positions on the displacement destination are used in an ascending order of the position numbers on the reagent loader  6 . While it is described that as for the logic for determining the positions on the reagent loader  6  that is the displacement destination, the order is the ascending order of the position numbers on the reagent loader  6 , the order is not limited to the ascending order but may be the descending order of the position numbers on the reagent loader  6  or the like. When the reagent containers  4  are fully installed at all the positions on the reagent loader  6 , the next reagent container cannot be unloaded until the reagent container  4  already installed at the position is taken outside from the reagent loader  6 . 
         [0081]    Mechanism control in the automated analyzer  100  according to the embodiment of the present invention will next be described with reference to  FIG. 7 .  FIG. 7  illustrates timing of operation (motions) per cycle of the outer circumferential holder  51  of the reagent cooler  5 , the reagent loader  6 , and the reagent container displacement mechanism  20 . A horizontal axis indicates time and it is assumed in the present embodiment that one cycle is 12 seconds. Analysis process is established by combining a plurality of cycles each corresponding to one cycle time. The mechanisms to operate vary depending on each cycle time, and the mechanism operation control section  119   d  manages control over those mechanisms, thereby performing the analysis. 
         [0082]    During the analysis, the outer circumferential holder  51  is driven to rotate, and sequentially implements following procedures: displacement before stirring of magnetic particles (motion 1) for transporting the reagent container that stores magnetic particles to be close to an access position of the stirring mechanism; displacement after stirring of magnetic particles (motion 2) for displacing the reagent container completed with stirring of the magnetic particles from the access position of the stirring mechanism; and displacement  1  for reagent dispensing (motion 3) and displacement  2  for reagent dispensing (motion 4) for displacing the dispensing target reagent container to an access position of the reagent dispensing mechanism. In addition, the outer circumferential holder  51  implements displacement for reagent loading/unloading (motion 5) for locating the vacant position on the outer circumferential holder  51  to be close to the reagent loader  6  so as to load the reagent container from the reagent loader  6  or for locating the position of the outer circumferential holder  51  that stores the reagent container to be close to the reagent loader  6  so as to unload the reagent container outside of the reagent cooler. 
         [0083]    The reagent container displacement mechanism  20  implements displacement before stirring of magnetic particles (motion 6) for drawing the reagent container transported by driving the outer circumferential holder  51  to rotate to the access position of the stirring mechanism, and displacement after stirring of magnetic particles (motion 7) for removing the reagent container completed with stirring of the magnetic particles from the access position of the stirring mechanism. In addition, the reagent container displacement mechanism  20  implements displacement for reagent loading/unloading (motion 8) for displacing the loading target reagent container from the reagent loader to the outer circumferential holder  51  or for displacing the loading target reagent container from the outer circumferential holder  51  to the reagent loader. 
         [0084]    Timing (first period  71 ) for the outer circumferential holder  51  to implement the motions 1 to 4 and for the reagent container displacement mechanism to implement the motions 6 and 7 is secured in one cycle in order to implement the analysis operation. In the first period  71 , the reagent loader  6  can vertically move at arbitrary timing in response to an operator&#39;s instruction and can implement operation for reagent loading/unloading. Timing (second period  72 ) for the outer circumferential holder  51  to implement the motion 5 and for the reagent container displacement mechanism to implement the motion 8 is also secured in one cycle in order to implement loading/unloading operation to load and unload the reagent container to or from the reagent reservoir  5 . In the second period  72 , the reagent loader  6  does not vertically move even if an operator&#39;s instruction is present since the reagent container displacement mechanism possibly accesses the reagent loader. While the second period  72  is set between the motions 3 and 4 in the present embodiment, the setting of the second period  72  is not limited thereto and at least one second period may be set in one cycle, i.e., a plurality of second periods  72  may be set in one cycle. Alternatively, the second period  72  may be set once in a plurality of cycles. 
         [0085]    As for timing and frequency of setting the second period  72 , it is preferable to set at least one second period  72  in one cycle time since the target reagent container  4  is possibly in a used condition (unusable condition as the reagent condition) when, for example, second reagent dispensing is implemented once among analysis steps. In the present embodiment, one second period  72  is set in one cycle time. However, in a case of the automated analyzer in which the number of positions of the reagent loader  6  is five or more, the reagent containers  4  are replaced frequently during the analysis, and many reagent containers  4  can be displaced for loading/unloading in a short time, the number of times of implementing the operation for displacement for reagent loading/unloading may be increased to the number such as two or three, while ensuring that the analysis operation and the use of the mechanisms do not overlap. If one second period  72  is set in one cycle, either loading operation or unloading operation is implemented in the cycle. If a plurality of second periods  72  are set in one cycle, the second periods may be used individually for loading and unloading such as one second period for unloading and the other second period for loading. 
         [0086]    If there is no reagent container to be loaded or unloaded, neither the outer circumferential holder nor the reagent container displacement mechanism operates in the second period. 
         [0087]    Setting the first period and the second period in one cycle enables the displacement operation for reagent loading/unloading to be implemented at the timing of receiving the operator&#39;s instruction via means such as the operation screen or the loader switch. 
         [0088]      FIG. 8  illustrates a flow for determining which is implemented, the loading operation of the reagent container  4  or the unloading operation thereof if one second period  72  is set in one cycle. 
         [0089]    First, when the timing at which loading/unloading of the reagent container can be implemented starts, the mechanism operation control section  119   d  obtains the information about the load reagent request and the information about the unload reagent request from the reagent loading/unloading information storage section  119   f  (Step S 801 ). The mechanism operation control section  119   d  confirms whether there is a load reagent request from the information about the load reagent request (Step S 802 ). 
         [0090]    When there is the load reagent request for the target reagent container  4  (Step S 802 ; YES), the mechanism operation control section  119   d  obtains the information about the reagent position condition on the reagent cooler  5  from the reagent position information storage section  119   h  (Step S 803 ). The mechanism operation control section  119   d  confirms whether all the positions are fully used in the outer circumferential holder  51  from the obtained information about the reagent position condition on the reagent cooler  5  (Step S 804 ). 
         [0091]    If all the positions are not fully used in the reagent cooler  5  (Step S 804 ; NO), the mechanism operation control section  119   d  creates information about mechanism control of reagent loading operation on the reagent cooler  5  and the reagent container displacement mechanism  20  (Step S 805 ), and stores the information about the mechanism control in the mechanism control information storage section  119   i  (Step S 810 ). 
         [0092]    If there is no information about the load reagent request in Step S 802  (Step S 802 ; NO) or if all the positions are fully used in the reagent cooler  5  in Step S 804  (Step S 804 ; YES), the mechanism operation control section  119   d  confirms whether there is an unload reagent request from the information about the unload reagent request obtained in Step S 801  (Step S 806 ). If there is no unload reagent request for the target reagent container  4  (Step S 806 ; NO), the process is ended. 
         [0093]    If there is the unload reagent request for the target reagent container  4  (Step S 806 ; YES), the mechanism operation control section  119   d  obtains the information about the reagent position condition on the reagent loader  6  from the reagent position information storage section  119   h  (Step S 807 ). The mechanism operation control section  119   d  confirms whether all the positions are fully used in the reagent loader  6  from the obtained information about the reagent position condition on the reagent loader  6  (Step S 808 ). If all the positions are fully used in the reagent loader  6  (Step S 808 ; YES), the process is ended. 
         [0094]    If all the positions are not fully used in the reagent loader  6  (Step S 808 ; NO), the mechanism operation control section  119   d  creates information about mechanism control of reagent unloading operation on the reagent cooler  5  and the reagent container displacement mechanism  20  (Step S 809 ), and stores the information about the mechanism control in the mechanism control information storage section  119   i  (Step S 810 ). 
         [0095]    If the reagent containers  4  are fully installed in all the positions on the outer circumferential holder  51  of the reagent cooler  5  in the automated analyzer  100  as a precondition, a new reagent cannot be loaded to the analyzer  100 . To prevent such a condition, the automated analyzer according to the present invention is configured such that whenever there is a reagent container that becomes unusable because, for example, none of the reagents is left or the reagent has expired, or there is a reagent container instructed to be unloaded by a user is automatically displaced from the outer circumferential holder  51  to the reagent loader  6  using the second period described above to secure as many vacant positions as possible on the outer circumferential holder  51 . 
         [0096]    By doing so, when the user instructs the reagent loader  6  to move upward by depression of the loader switch or the like, then the reagent loader  6  moves upward, and the reagent container  4  stored in the position on the reagent loader  6  is unloaded outside of the reagent cooler  5 . After the vacant position is secured on the outer circumferential disk of the reagent cooler  5  by the operation described above, the user installs the reagent container  4  to be loaded to the reagent cooler  5  at the position and instructs the reagent loader  6  to move downward, thereby making it possible to load the reagent container  4  into the reagent cooler  5 . 
         [0097]    Furthermore, the unloading target reagent container is displaced to the vacant position on the reagent loader  6  whenever the unloading target reagent container occurs. Therefore, even if the reagent container instructed to be loaded and the reagent container instructed to be unloaded are present in the reagent cooler, it is possible to give higher priority to the displacement of the reagent container instructed to be loaded and to promptly supplement the necessary reagent container. 
         [0098]    Moreover, before start of the displacement for the reagent loading or unloading to/from the reagent cooler  5 , the information about the load reagent request or the information about the unload reagent request from the reagent loading/unloading management section  119   a  or the input section  19   c  is stored in the reagent loading/unloading information storage section  119   f  Therefore, the mechanism operation control section  119   d  can control the reagent cooler  5  and the reagent container displacement mechanism  20  to operate to load/unload the reagent container  4  certainly once per cycle time. While it is described in the present embodiment that the automated analyzer  100  is an automated immune analyzer, the automated analyzer  100  may be a biochemical automated analyzer, and contents of the analysis operation performed by the reagent cooler  5 , the reagent loader  6 , and the reagent container displacement mechanism  20  vary depending on analysis steps and configurations of the mechanisms. 
         [0099]    A screen used when the operator confirms whether the reagent container  4  is loadable or unloadable will next be described with reference to  FIG. 9 . The display section  19   b  includes the reagent loadable/unloadable display section  119   k , and the reagent loadable/unloadable display section  119   k  includes a reagent loadable/unloadable confirmation screen  22 . 
         [0100]    As shown in  FIG. 9 , the reagent loadable/unloadable confirmation screen  22  includes an analyzer name display section  22   a , a reagent loadable/unloadable information display section  22   b , a load/unload reagent request result display section  22   c , and a screen close button  22   d.    
         [0101]    The reagent loadable/unloadable confirmation screen  22  can be opened from the display section  19   b  and displays reagent loadable/unloadable information and a load/unload reagent request result. The operator can close the reagent loadable/unloadable confirmation screen  22  by depressing the screen close button  22   d . The reagent loadable/unloadable information displayed on the reagent loadable/unloadable confirmation screen  22  is configured with the analyzer name display section  22   a  and the reagent loadable/unloadable information display section  22   b . The operator can confirm the reagent loadable/unloadable information per analysis module by referring to the reagent loadable/unloadable confirmation screen  22 . 
         [0102]    As the load/unload reagent request result on the reagent loadable/unloadable confirmation screen  22 , a date, time, each target analysis module, and the load/unload reagent request result are displayed on the load/unload reagent request result display section  22   c  when the operator issues a load/unload reagent request to the automated analyzer  100  via the reagent loader switch  21 . It is possible to confirm previous request process results by scrolling the load/unload reagent request result display section  22   c.    
         [0103]    The reagent loading/unloading management section  119   a  obtains information about a control condition on each mechanism from the mechanism operation control section  119   d  and obtains information about an analyzer condition from the analyzer condition management section  119   e  at regular intervals. The reagent loading/unloading management section  119   a  determines whether the reagent container is loadable or unloadable on the basis of the obtained information, and stores a determination result in the reagent loading/unloading information storage section  119   f  as the reagent loadable/unloadable information. In this case, if the reagent loadable/unloadable information differs between before update and after update, the reagent loading/unloading management section  119   a  transmits, to the reagent loadable/unloadable display section  119   k , a request to update display of the reagent loadable/unloadable information. 
         [0104]    Upon receiving the request to update the display of the reagent loadable/unloadable information, the reagent loadable/unloadable display section  119   k  updates the reagent loadable/unloadable confirmation screen  22  to display latest reagent loadable/unloadable information in the reagent loadable/unloadable information display section  22   b  corresponding to each of the analysis modules displayed in the analyzer name display section  22   a . The operator can recognize whether the automated analyzer  100  is in a condition of being able to load/unload the reagent container  4  by confirming the reagent loadable/unloadable confirmation screen  22 . 
         [0105]    While the reagent loadable/unloadable confirmation screen  22  displays both the reagent loadable/unloadable information and the load/unload reagent request result in the embodiment of the present invention, the reagent loadable/unloadable confirmation screen  22  does not necessarily display both of the information but may display only one of the reagent loadable/unloadable information and the load/unload reagent request result, and the two pieces of information may be displayed on different screens. 
         [0106]      FIG. 10  illustrates a process flow when the operator depresses the reagent loader switch  21  to instruct the automated analyzer  100  to load/unload the reagent container  4 . 
         [0107]    The operator can instruct the automated analyzer  100  to start loading/unloading the reagent container  4  by operating the reagent loader switch  21 . When operator&#39;s depressing the reagent loader switch  21  is detected (Step S 100 ), the load/unload reagent request input section  119   j  requests the reagent loading/unloading management section  119   a  to start operation for reagent container loading/unloading. The reagent loading/unloading management section  119   a  obtains the reagent loadable/unloadable information from the reagent loading/unloading information storage section  119   f , and confirms whether the reagent container  4  is loadable/unloadable (Step S 101 ). The determination of whether the reagent container  4  is loadable/unloadable is made by referring to the information about the position condition and the information about the analyzer condition. Specifically, the determination depends on whether there is a vacant position on the outer circumferential holder  51  and whether the analyzer condition is a condition in which the operation for the reagent container loading/unloading is possible. 
         [0108]    When the reagent container  4  is loadable/unloadable (Step S 102 ; YES), the reagent loading/unloading management section  119   a  starts process for loading/loading the reagent container  4  (Step S 103 ). The reagent loading/unloading management section  119   a  then displays, on the reagent loadable/unloadable display section  119   k , that is, on the load/unload reagent request result display section  22   c  on the reagent loadable/unloadable confirmation screen  22 , the request result to the effect that the request to load/unload the reagent container  4  has been accepted (Step S 104 ), thus ending the process (Step S 105 ). 
         [0109]    On the other hand, when the reagent container  4  is not loadable/unloadable (Step S 102 ; NO), the reagent loading/unloading management section  119   a  displays, on the reagent loadable/unloadable display section  119   k , that is, on the load/unload reagent request result display section  22   c  on the reagent loadable/unloadable confirmation screen  22 , the request result to the effect that the request to load/unload the reagent container  4  is unacceptable (Step S 104 ), and the process for loading/unloading the reagent container  4  is not implemented. The operator can recognize whether the request to load/unload reagent has been accepted by confirming the load/unload reagent request result display section  22   c  on the reagent loadable/unloadable confirmation screen  22 . 
         [0110]    While the reagent loader switch  21  is a hardware switch in the embodiment of the present invention, the reagent loader switch  21  is not limited to the hardware switch but may be a software switch such as the key on the screen of the display section  19   b.    
       REFERENCE SIGNS LIST 
       [0000]    
       
           1 : Sample container 
           2 : Sample container rack 
           3 : Rack transport line 
           4 : Reagent container 
           4   a : Inner bottle 
           4   b : Intermediate bottle 
           4   c : Outer bottle 
           4   d : Individual identification label 
           5 : Reagent cooler 
           51 : Outer circumferential holder 
           52 : Inner circumferential holder 
           53 : Position 
           6 : Reagent loader 
           6   a : Reagent loading position 
           6   b : RFID read-out position 
           6   c : Reagent installation position 
           7 : Reagent cooler cover 
           7   a : Reagent cooler cover opening 
           8 : Reaction container 
           9 : Incubator disk 
           10 : Sample dispensing mechanism 
           11 : Reagent dispensing mechanism 
           12 : Reaction container/sample dispensing chip storage section 
           13 : Reaction container/sample dispensing chip storage section 
           15 : Disposal hole 
           16 : Transport mechanism 
           16   a : Chip attachment position 
           17   a ,  17   b : Nozzle 
           18   a ,  18   b : Detection unit 
           19 : Control section 
           19   a : Controller 
           119   a : Reagent loading/unloading management section 
           119   b : Reagent condition management section 
           119   c : Reagent position management section 
           119   d : Mechanism operation control section 
           119   e : Analyzer condition management section 
           19   b : Display section 
           119   k : Reagent loadable/unloadable display section 
           19   c : Input section 
           119   j : Load/unload reagent request input section 
           19   d : Storage section 
           119   f : Reagent loading/unloading information storage section 
           119   g : Mounted reagent information storage section 
           119   h : Reagent position information storage section 
           119   i : Mechanism control information storage section 
           20 : Reagent container displacement mechanism 
           21 : Reagent loader switch 
           22 : Reagent loadable/unloadable confirmation screen 
           22   a : Analyzer name display section 
           22   b : Reagent loadable/unloadable information display section 
           22   c : Load/unload reagent request result display section 
           22   d : Screen close button 
           100 : Automated analyzer 
           71 : First period 
           72 : Second period