Abstract:
An inhalation device for the uptake of medicaments that are in the form of dry powder contained in the blisters of specially designed single dose blister strips. The device is comprised of a mouthpiece (A), a strip support surface area (B). and one or more storage areas (C). Furthermore, the single dose blister strip is described. It is comprised of two sheets (17, 20) that are fixed in such a manner so that when they get separated the powder becomes available for inhalation.

Description:
BACKGROUND OF THE INVENTION 
     The present invention refers to an inhaler for the uptake of medicaments in the form of dry powder and to specialty designed single dose blister strips that are used with the said inhaler. 
     FIELD OF THE INVENTION 
     The inhaling devices currently used can be separated into two categories: 
     1. Those where the pharmaceutical powder is stored in a container out of which a measured amount of powder can be released via specific mechanisms. EP0069715 for example, describes a device in which the powder is metered in given dosages through apertures located in a rotatable disc, these apertures being introduced into an airduct or channel through which air is inhaled, by rotating the disc. 
     DESCRIPTION OF PRIOR ART 
     2. Those where measured amounts of pharmaceutical powder can be stored separately in special containers. GB2242134 for example, describes a device which uses a flexible strip defining a plurality of pockets each of which contains a dose of medicament which can be inhaled. The device contains a chamber in which the strip is housed, an opening station which contains means for peeling the two sheets or the strip apart and an outlet through which the user can inhale the medicament. 
     The major disadvantages of these and other similar devices are that a. the user cannot visually verify whether he has received the entire dose of the medicament, and b. they function through complicated internal mechanisms. 
     SUMMARY OF THE INVENTION 
     The advantage of the present invention is that the user can visually check the presence of the medicament in the blister of the strip prior to inhalation and verify after the inhalation that he has received the entire dose of the medicament. Additionally, the device is simple to manufacture and easy to operate. 
     The device of the present invention is comprised of three parts: the mouthpiece, through which the powder is inhaled, the blister strip support surface and the strip storage compartment(s), which house(s) a large number of blister strips. The three parts are connected to each other and can be independently opened. The support surface contains an attachment point, where the blister strip is attached with the help of an attachment formation; a cavity, which accommodates the blister of the strip; and strip guides, which secure the proper and firm placement of the strip on the surface. The single dose blister strip is comprised of two sheets that can be pealed away from each other. The base sheet has a blister which contains the powder, and an attachment formation which fits to the attachment point of the support surface. The cover sheet seals the base sheet only in the area around the blister. The principle of use is that the user securely attaches the blister strip on the attachment surface, pulls away the cover sheet of the blister by exercising a slight force, checks the content of the blister, inhales the medicament, and finally verifies that he has received the entire dose. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         FIGS. 1-9  depict examples of the invention. 
         FIG. 1  shows different views of an example of an inhaler. 
         FIG. 2  shows the mouthpiece of the device along with its component parts. 
         FIG. 3  shows the part of the device that contains the area on which the blisters are placed. 
         FIG. 4  shows the blister storage compartment. 
         FIG. 5  shows a single dose blister strip and the way it is put together. 
         FIG. 6  shows the process that reveals the powder in the blister. 
         FIG. 7  shows the flow of air and powder during the inhalation process. 
         FIGS. 8 and 9  are further examples of inhalers based on the principle of the present invention. 
     
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
     The inhaler ( FIG. 1 ) includes 3 basic parts, the mouthpiece A with its cover, part B with the surface on which the blister strip is placed, and the blister strip storage part C. The parts are connected to each other and can be opened independently. 
     The mouthpiece ( FIG. 2 ) is comprised of parts  1 ,  2  and  3 . Part  1  locks in part  2  and part  2  locks in part  3 . 
     Part  1  is the external part of the mouthpiece, and may have air openings at its base. 
     Part  2  is a cylinder with a wider base. The top of the cylinder has an opening  4 , which serves as the exit of the powder from the device. Inside the cylinder there is formation  5 , which may be of helical or other shape, through which the inhaled powder containing air exits the device. The end of formation  5  at the base of part  2  is blocked in half with surface  6 . 
     Part  3  is also a cylinder, which has a wider top. The interior of part  3  is divided into in chambers  7  and  8 , by an upright flat divider surface  9 . The base of part  3  touches the blister. It has two holes,  10  and  11 , one on each side of divider  9 . Hole  11  may contain a sieve, in order to black the passage of larger particles. Chamber  7  contains hole  10 , and is blocked at its top with surface  6 . Furthermore, chamber  7  contains hole  12 , which serves as the air entrance. 
     The single dose blister strip is placed on the attachment surface of part B ( FIG. 3 ). This surface has a protrusion  13  that serves as the attachment point, a cavity  14  which receives the blister of the strip, and a system of strip guides,  15  and  16  in the specific example. The protrusion, the cavity and the guides enable the correct alignment of the strip on the surface of part B and secure its firm placement during the use of the device. The lower portion of part B can be used as a storage compartment for the blister strips. 
     The strip storage part C ( FIG. 4 ) can be of various shapes, and may contain a grid, depending on the number of strips it accommodates, e.g. 30 or 60. 
     The blister strip ( FIG. 5 ) consists of two sheets ( FIG. 5A ) made of suitable material e.g. PVC, aluminium, polyamide, paper, polyester, vinyl gum. One of the two sheets is the base sheet  17 , which has the blister  18  that contains the powder, and the attachment hole  19 . The other is the cover sheet  20  that is fixed to the base sheet, e.g. by heat adhesion, and air-tightly seals only the area around blister  18 , as shown in the drawing ( FIG. 5B , darkened area). Sheet  20  is then folded by a 180-degree rotation around axis DE, revealing hole  19  and covering the flat surface of blister  18  ( FIG. 5C ). 
     The process by which the blister-contained powder is exposed takes place in two stages ( FIG. 6 ). 
     During the first stage  FIG. 6A ) and while the mouthpiece is open, the user secures the strip on the support surface of part B by placing hole  19  around protrusion  13 . Blister  18  is then placed in cavity  14  with the assistance of guides  15  and  16 . During the second stage ( FIG. 6B ), the user closes the mouthpiece and pulls cover sheet  20  towards the direction of the arrow until it is completely detached. 
     At this point and after lifting the mouthpiece, the user can verify that the powder contained in blister  18  has been revealed and is available for inhalation ( FIG. 6C ). The user then just closes the mouthpiece and inhales. Finally, by opening again the mouthpiece, he can visually check whether he has inhaled the medicament. 
     During the process of inhalation ( FIG. 7 ) the air that is breathed-in enters the mouthpiece via the air openings, and then enters chamber  7  through hole  12 . From there on and passing through hole  10 , the air carries along the powder which is located in blister  18  and passing through hole  11  brings it to chamber  8 . From there and through formation  5 , the powder exits the device. 
     Another example of the invention is shown in  FIG. 8 . The attachment point for the blister strip on surface B is cavity  21 . The mouthpiece A contains projection  22  which, when said mouthpiece is closed, enters cavity  21  and in this way secures the blister. In this case, the blister is placed on surface B with hole  19  above cavity  21 . Alternatively, blister strip hole  19  could be replaced by a cavity. 
       FIG. 9  shows another embodiment of the invention. In this case, the attaching component of the blister strip is formation  23  that is placed in the openings  24  of guides  15  and  16  of surface B. 
     It is obvious that there may be variations relating to the shape and the positions of the attachment point, the cavity and the guides on surface B, which can achieve appropriate and secure attachment of the blister. All these different embodiments are also included in the scope of the present invention. 
     A further embodiment of the inhaler would include its use through the nose. This could be achieved by substituting the mouthpiece with the appropriate attachment.