Abstract:
The invention relates to the detection or prediction of metastases of head and neck squamous cell carcinoma (HNSCC) with the use of gene expression profiles. A gene signature has been identified which is able to detect or predict the occurrence of these metastases better than current clinical methods. Part of the invention are micro-arrays comprising this signature and methods for performing the detection and/or prediction.

Description:
FIELD OF THE INVENTION 
       [0001]    The invention relates to the field of tumour diagnosis, in particular to predict the existence of metastases of a tumour, more in particular to the detection of lymph node metastases of head and neck squamous cell carcinoma (HNSCC) especially those that arise in the oral cavity and oropharynx. 
       STATE OF THE PRIOR ART 
       [0002]    Head and neck squamous cell carcinoma (HNSCC) consists of a heterogenous group of neoplasms that arise from the epithelium of the upper aero-digestive tract. HNSCC is the fifth most common malignancy in humans and is particularly frequent in regions where alcohol and tobacco use is high (Sankanarayanan, R. et al., (1998) Anticancer Res. 18, 4779-4786). The survival rate of patients with cervical lymph node metastases is reduced by almost 50% (Jones, A. S. et al., (1994) Clin. Otolaryngol. 19, 63-69; Hahn, S. S. et al., (1987) J. Radiat. Oncol. Biol. Phys. 13, 1143-1147). As with most forms of cancer, treatment depends largely on progression stage (Forastiere, A. et al., (2001) N. Eng. J. Med. 345, 1890-1900). 
         [0003]    Metastasis is the process whereby cancers spread to distinct sites in the body. It is the principal cause of death in individuals suffering from cancer. For some tumor types, the earliest detectable sign of metastasis is the presence of malignant cells in lymph nodes close to the site of the primary tumour. Early detection of local lymph node metastases is currently pivotal for appropriate treatment of many types of cancer. However, because of difficulties in detecting lymph node metastases reliably, many patients currently receive inappropriate treatment. 
         [0004]    Most patients with HNSCC, especially those in the oral cavity or oropharynx have the primary tumour removed. Treatment of clinically diagnosed lymph node metastasis positive patients (N+) involves the additional surgical removal of a significant portion of the neck, including all five local lymph node levels: radical neck dissection (RND) (Robbins, K. T. et al., (2002) Arch. Otolaryngol. Head Neck Surg. 128, 751-758). However, after histological examination of the removed tissue, approximately 10-20% of the clinically diagnosed N+ patients appear to be N0 (metastasis free) (Woolgar, J. A., (1999) Br. J. Oral Maxillofac. Surg. 37, 205-209). Clinical diagnosis of N0 lymph node status is even less accurate. Histological examination of electively operated clinically diagnosed N0 patients reveals that about one-third have positive neck nodes (Jones, A. S. et al., (1993) Eur. Arch. Otorhinolaryngol. 250, 446-449). Different strategies exist for neck treatment of N0 diagnosed patients (Pillsbury, H. C., et al., (1997) Laryngoscope 107, 1294-1315). One is the so-called “watch and wait” strategy by which N0 diagnosed patients do not undergo any neck dissection. The involves the risk of fatality by allowing overlooked metastases to develop and spread further. Since the prevalence of false-negative predictions is very high, most clinics perform neck surgery for all diagnosed N0 patients. In this case most often a supra-omohyoidal neck dissection (SOHND) is performed, removing the three upper lymph node levels (Robbins, K. T. et al., supra). This treatment is less appropriate than an RND for those N+ patients falsely diagnosed as N0 and, moreover, completely unnecessary for all patients correctly diagnosed as N0. Although SOHND is less rigorous than RND, the treatment cause disfigurement, long-term discomfort, pain and can lead to additional complications such as shoulder disability (e.g. Short, S. O. et al., (1984) Am. J. Surg. 148, 478-482). Both treatments strategies result in over- or undertreatment due to limitations in detecting lymph node metastasis reliably. 
         [0005]    DNA microarray based gene expression profiling has previously been shown to be useful for cancer classification (e.g. Valk, P. J. et al., (2004) N. Eng. J. Med. 350, 1605-1616) and prognosis-based treatment (Van &#39;t Veer, L. J. et al., (2002) Nature 415, 530-536 and WO 2004/065545). Gene expression profiling has revealed genes that are differentially regulated in metastases (Clark, E. A. et al., (2000) Nature 406, 532-535; Saha, S. et al., (2001) Science 294, 1343-1346) and a 17-gene expression signature was recently found that is common to both primary tumours and metastases (Ramaswamy, S. et al., (2003) Nat. Genet. 33, 49-54). It was also found that a signature derived from fibroblasts which are active in wound healing can be predictive for metastasis in several tumour types (Chang, H. Y., et al. (2004) PLoS Biol. 2(2):e7, to be found at: http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=314300). 
         [0006]    For HNSCC such expression signatures are starting to be uncovered (Chung, C. H. et al., (2004) Cancer Cell 5, 489-500), but as yet without independent validation for reliability and clinical outcome. 
         [0007]    Thus, there is still a large need for a reliable diagnostic tool on basis of expression of genes with which a reliable and accurate prediction can be established for the presence or occurrence of lymph node metastasis in HNSCC. 
       SUMMARY OF THE INVENTION 
       [0008]    The invention now provides a nucleotide array of maximal 50 nucleotide sequences, preferably maximal 100 nucleotide sequences, more preferably maximal 1000 nucleotide sequences, for the detection of metastasis in head and neck squamous cell cancer (HNSCC) comprising at least 1 of the elements of Table 5, more preferably 2 of the elements, more preferably 3 of the elements, more preferably 4 of the elements, more preferably 5 of the elements, more preferably 6 of the elements %, more preferably 7 of the elements, more preferably 8 of the elements, more preferably 9 of the elements, more preferably 10 of the elements and most preferably at least 20 of the elements. Alternatively, a nucleotide array for the detection of metastasis in HNSCC has 50 or more of the elements of the genes listed in Table 4. 
         [0009]    Further provided is a method to establish reference and control gene expression profiles of patients having had metastasis after HNSCC(N+ group) or no metastasis after HNSCC(N0 group) by analysing the gene expression from a tumour biopsy sample of each patient, or from pooled samples of each group of patients, on an array according to the invention. 
         [0010]    Another embodiment of the invention is a method to predict the presence or risk of occurrence of lymph node metastasis of a HNSCC patient. comprising: 
         [0011]    a. taking a biopsy sample from the tumour of the patient; 
         [0012]    b. isolating the nucleic acid from the biopsy sample; 
         [0013]    c. analyse the gene expression profile of said nucleic acid by assaying it with a nucleotide array according to the invention; 
         [0014]    d. classifying the expression profile as N+ or N0 by determining whether the expression profile would match the expression profile of a group of HNSCC patients known to have developed metastasis. 
         [0015]    Preferably, the biopsy samples in the above methods are fresh biopsy samples. 
         [0016]    A preferred embodiment for the method to predict the presence or risk of metastasis is a method, wherein the analysis of the gene expression profile comprises: 
         [0017]    a. hybridising the nucleic acid form the biopsy sample with the nucleotide array according to the invention; 
         [0018]    b. determining the amount of hybridisation of each of the elements of the nucleotide array relative to the amount of hybridisation of each element with a reference sample, said step optionally involving a normalisation step; 
         [0019]    c. determining for each element of the array whether the expression of the corresponding gene in the biopsy sample is more or less than the expression of the corresponding gene in the reference sample. 
         [0020]    Preferably, the expression profile is classified as N+ (high risk of metastasis) or N0 (low or no risk of metastasis) according to the steps of: 
         [0021]    a. determining the collective correlation of the classifier/predictor genes or elements present in the expression profile with the average N+ or N0 profile from primary tumors with previously established N-status; and 
         [0022]    b. determining the predictive threshold based on the correlation threshold from primary tumors with previously established N-status 
         [0023]    In another preferred embodiment the method is a method, wherein the gene expression profile of a group of HNSCC patients known to have developed metastasis is the expression profile contained in the dataset E-UMCU-11, available in the public microarray database ArrayExpress (http://www.ebi.ac.uk/arrayexpress/). 
         [0024]    Calculation of the correlation as performed in the above methods is preferably done using the cosine correlation method. 
         [0025]    Normalization of the expression profile is preferably achieved by correcting the expression data for experimental variations with the help of expression data of a control gene or element which is not affected by the tumour state, preferably by calculating the ratio of the expression data of each gene or element in the array of claim  1  or  2  with the expression of a control gene or element or the mean of a pool of control genes or elements. 
     
    
     
       LEGENDS TO THE FIGURES 
         [0026]      FIG. 1 . A predictor for HNSCC lymph node metastasis. (a) Expression profiles of the 102 predictor genes on the 82 primary tumor training set (middle). The predictor genes are clustered based on their similarities across the 82 tumors (Pearson around zero correlation, centroid clustering). Tumors are rank-ordered according to their correlation with the average N0 expression profile (left). The solid line represents the threshold for optimal overall accuracy. Tumors above the threshold show an expression profile that indicates that the patient is free of lymph node metastasis. In the right panel the patient&#39;s histological N-status, including the 3 year follow-up period, and the clinical diagnosis are shown (black indicates post-operative histological N+, white indicates post-operative histological N0, dark grey indicates clinical N+ and light grey indicates clinical N0 assessment). The asterix indicates a patient that developed lymph node metastasis post-treatment. (b) Expression profiles and tumor correlations from 6 training tumors samples (circles) and their technical replicates (squares). (c) as (a) only for a independent validation set of 22 primary HNSCC tumors. The threshold is set according to the optimal threshold established with the latter half of the training set ( FIG. 2   d ). 
           [0027]      FIG. 2 . Long-term tissue storage results in loss of predictive accuracy. (a) The mean correlation with the average no-metastasis profile and the standard deviation range for N0 patients (blue) and N+ patients (red) in the training set are shown for each year of surgery. (b) The N0 (blue), N+ (red) and overall (green) predictive accuracies increase from 40-45% for samples from 1996, to 89-100% for samples from 2000. (c, d) Correlation data from tumors with longer (c) or shorter (d) storage time. The predictor correctly predicts 22 of the 38 and 38 of the 44 samples, respectively. 
           [0028]      FIG. 3 . The predictor outperforms current clinical diagnosis on the validation set. (a) Predictive accuracies (PA) of current clinical diagnosis (blue) and the predictor (red) on the validation set. Error bars are based on the standard error for predictive accuracy. The predictor has a N0 PA of 100%, N+ PA of 77%, and overall PA of 86%. Clinical diagnosis has a N0 PA of 67%, N+ PA of 71%, and overall PA of 68%. (b, c) Treatment accuracy for the validation set, based on current clinical diagnosis (b) or if based on predictor outcome (c). Completely appropriate treatment is shown in green and under- or overtreatment in red. Current diagnosis resulted in 23% of patients receiving appropriate treatment (50% of N+ receiving an RND). Predictor based treatment would result in 86% of patients receiving appropriate treatment (75% of N0 that no longer receive any neck dissection and 100% of N+ receiving a RND). 
           [0029]      FIG. 4 . Study design and procedures overview. a, RNA was isolated from 2-3 tumor sections, followed by mRNA amplification and fluorescent labeling. After hybridization, scanned images were quantified and the data was normalized. Duplicates of each tumor were averaged and a predictor was designed using the differentially expressed genes. Quality control monitoring occurred after total RNA isolation, cRNA synthesis, labeling, scanning and normalization. b, The training experiment design involved 82 primary HNSCC tumors, compared in duplicate dye-swap against a common reference pool containing equal amounts of cRNA from each tumor. Nine reference pool self-self comparisons were generated in parallel, to establish an error-model for technical variation. c, The predictor was designed using a double loop training-validation protocol. 
           [0030]      FIG. 5 . The predictive outcome of different signatures is stable. Predictive correlation outcome of 66 tumor samples using a multiple training approach. A thousand different molecular signatures comprising 50 (A), 100 (B) or 200 (C) genes were used to predict each sample approximately 100 times. Samples from patients without metastasis are colored blue (top line in the graph), samples from patients with lymph node metastasis are colored red (bottom line in the graph). The shaded area represents the 95%-confidence interval for the sample predictions. 
       
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
       [0031]    The inventors herein show that it is possible to give a more accurate prediction of the presence of lymph node metastasis of HNSCC than currently possible, by measuring mRNA expression of a concise set of genes (the predictor signature). It appeared possible to give an accurate prediction on basis of a set of 102 genes listed in Table I. It appeared that half of these genes have not been directly associated with tumorigenesis or metastasis before. Besides expected epithelial marker genes, interesting categories include genes (putatively) coding for extracellular matrix components, genes involved in cell adhesion including three members of the plakin family of cytolinkers and the enzyme transglutaminase 3, which play a role in maintaining tissue integrity; cell death genes; cell growth and maintenance genes and genes encoding hydrolyzing activities including proteins involved in degradation of the extracellular matrix (uPA and PAI-1) and a metalloproteinase. Another feature of the metastasis signature is that there is more down-regulation associated with metastasis (two thirds) than up-regulation. It is likely that this involves stromal and immune-regulatory components (Pollard, J. W. (2004) Nat. Rev. Cancer 4, 71-78; Chambers, A. F. et al. (2002) Nat. Rev. Cancer 2, 563-572). Many of the predictor genes belong to this categories, strengthening the argument for profiling bulk tumour tissue rather than laser-dissected regions densely populated with tumour cells. 
         [0032]    It is shown herein that a diagnosis/prediction of the presence of metastases can be given using expression data of a set of only five genes from this large set of 102 genes. Table 2 indicates 15 of the genes which rank high in predictive value and which can especially be used to give a diagnosis or prediction of metastasis in HNSCC. Of course, accuracy of prediction will increase when more then five, preferably all 15 and even more preferably all 102 genes will be used on an array for gene expression analysis for the diagnostic/predictive signature. 
         [0033]    Gene expression analysis is preferably done using a micro-array. The techniques for measuring and comparing gene expression on micro-arrays is well established within the art. It should be understood that it is not necessary to have the full length nucleotides encoding the above mentioned genes on said array: a stretch of nucleotides which is sufficient to establish unique hybridisation with the RNA expressed from said genes in the tumour cells can be used. Such a stretch of nucleotides is hereinafter referred to as ‘element’. Preferably for the specific use of gene expression analysis for the current invention (i.e. with relation to detection of the presence of or the risk for metastases of HNSCC) such an array need not contain a large number of (different) genes or elements. It would be sufficient for the array to contain the necessary genes, as discussed above, and, preferably, some control genes, as will be discussed below. The array, which can be used for the analysis of the invention thus does not need to contain more than 1000 genes or elements, preferably not more than 500 genes or elements, more preferably not more than 200 genes or elements and most preferably from about 50 to about 150 genes or elements. 
         [0034]    To investigate a gene expression profile the array should be subjected to hybridisation with target polynucleotide molecules from a clinically relevant source, in this case e.g. a person with HNSCC. Therefore, preferably a fresh frozen (within 1 hour from surgical removal), liquid nitrogen (at least −80° C.) stored tumour sample needs to be available. Said target polynucleotide molecules should be expressed RNA or a nucleic acid derived therefrom (e.g., cDNA or amplified RNA derived from cDNA that incorporates an RNA polymerase promoter). If the target molecules consist of RNA, it may be total cellular RNA, poly(A) +  messenger RNA (mRNA) or fraction thereof, cytoplasmic mRNA, or RNA transcribed from cDNA (cRNA). Methods for preparing total and poly(A) +  messenger RNA are well known in the art, and are described e.g. in Sambrook et al., (1989) Molecular Cloning—A Laboratory Manual (2 nd  Ed.) Vols. 1-3, Cold Spring Harbor, N.Y. In one embodiment, RNA is extracted from cells using guanidinium thiocyanate lysis followed by CsCl centrifugation (Chrigwin et al., (1979) Biochem. 18:5294-5299). In another embodiment, total RNA is extracted using a silica-gel based column, commercially available examples of which include RNeasy (Qiagen, Valencia, Calif., USA) and StrataPrep (Stratagene, La Jolla, Calif., USA). Poly(A) +  messenger RNA can be selected, e.g. by selection with oligo-dT cellulose or, alternatively, by oligo-dT primed reverse transcription of total cellular RNA. In another embodiment, the polynucleotide molecules analyzed by the invention comprise cDNA, or PCR products of amplified RNA or cDNA. 
         [0035]    Preferably, the target polynucleotides are detectably labelled at one or more nucleotides. Any method known in the art may be used to detectably label the nucleotides. Preferably, this labelling incorporates the label uniformly along the length of the polynucleotide and is carried out at a high degree of efficiency. One embodiment for this labelling uses oligo-dT primed reverse transcription to incorporate the label; however, conventional methods hereof are biased toward generating 3′ end fragments. Thus, in this embodiment, random primers (e.g. 9-mers) are used in reverse transcription to uniformly incorporate labelled nucleotides over the full length of the target polynucleotides. Alternatively, random primers may be used in conjunction with PCR methods or T7 promoter-based in vitro transcription methods in order to amplify the target polynucleotides. 
         [0036]    In a preferred embodiment, the detectable label is a luminescent label. For example, fluorescent labels, bioluminescent labels, chemiluminescent labels and calorimetric labels may be used. In a highly preferred embodiment, the label is a fluorescent label, such as a Cy5 or Cy3, fluorescein, a phosphor, a rhodamine, or a polymethine dye or derivative. In another embodiment, the detectable label is a radiolabeled nucleotide. 
         [0037]    The array may be any nucleotide array which represents five or more of the genes of Table 2 or Table 1. To indicate the difference with the existing very large arrays of e.g. Affymetrix, the dedicated arrays of the present invention should preferably comprise no more than 50, or 100, or 250 or, alternatively 500 or 1000 genes altogether. Presence of other genes on the array is allowable and the expression data from such other genes need not necessarily be considered for the present application. The methods of the invention can be applied on the above mentioned dedicated arrays, but can also be performed on arrays that are commercially available (e.g. from Agilent US; Affymetrix Inc, CA, USA; and others). It is also possible to work with self-made arrays by spotting or synthesizing nucleotides which are known to selectively hybridise to the target genes on a surface. Methods to prepare such arrays are well within the skill of the artisan. The microarrays can comprise cDNA, but can also comprise short oligonucleotides (Affymetrix and Nimblegen) or long oligonucleotides which are synthesized in situ_(Agilent); in another embodiment the arrays comprise long oligonucleotides and are self-made by spotting. 
         [0038]    Nucleic acid hybridisation and wash conditions are chosen so that the target polynucleotide molecules specifically hybridize to the complementary polynucleotide sequences of the array, preferably to a specific array site, wherein its complementary DNA is located. Optimal hybridisation conditions will depend on the type (e.g., RNA or DNA) of the target nucleotides and array. General parameters for specific (i.e., stringent) conditions of hybridisation are described in Sambrook et al. (supra). Typical hybridisation conditions for cDNA microarrays are hybridisation in 5×SSC plus 0.2% SDS at 65° C. four hours, followed by washes at 25° C. in low stringency wash buffer (1×SSC plus 0.2% SDS), followed by 10 minutes at 25° C. in higher stringency wash buffer (0.1×SSC plus 0.2% SDS). 
         [0039]    When fluorescently labelled probes are used, the fluorescence emissions at each site of the microarray may be detected by scanning confocal laser microscopy. In one embodiment, the arrays is scanned with a laser fluorescent scanner with a computer controlled X-Y stage and a microscope objective. Fluorescent laser scanning devices are described in e.g. Schena et al. (1996) Genome Res. 6:639-645. Signals are recorded and, in a preferred embodiment, analysed by computer using a 12 or 16 bit analog to digital board. In one embodiment the scanned image is despeckled using a graphics program (e.g., Hijaak Graphics Suite) and then analysed using an image gridding program that creates a spreadsheet of the average hybridisation at each wavelength at each site. 
         [0040]    Not all of the genes are evenly contributing to the discriminating effect. As is shown in Table 1, the genes differ in significant expression. Although the statistical data presented in the Examples are calculated with all of the 102 genetic elements of Table 1, it is submitted that a good distinction between the two groups of patients and therewith a good diagnosing/predicting ability of the signature gene set can also be achieved with only a part of the elements of Table 1. At least 5 (5%) of the elements of Table 1 are included in the analysis, more preferably 20%, more preferably 40%, more preferably 60%, more preferably 80%, more preferably 90% and most preferably all of the elements. It would be advisable not to randomly choose the elements, but to pick the most discriminating genes in this list. Table 2 gives an overview of the top 15 genes out of the 102 genes of table 1, of which at least 5, more preferably at least 6, more preferably at least 7, more preferably at least 8, more preferably at least 9, more preferably at least 10, more preferably at least 11, more preferably at least 12, more preferably at least 13, more preferably at least 14, and most preferably all 15 can be used for making up the signature with which the microarray analysis is performed. 
         [0041]    It furthermore has been found that a more comprehensive set of predicting genes can be compiled by repeatedly calculating a predictive signature via a multiple training approach (similar to Michiels, S. et al., Lancet 365:488-492, 2005). In this study (see Examples) it appeared that from the originally more than 2000 differentially expressed genes only 825 (Table 3) had a predictive character, and that for these a subgroup of 179 (Table 4) genes was used in more than half of the signatures. From this group again a supergroup of 61 genes (Table 5) could be distinguished which was predominantly used to discriminate between N+ and N0. It will be understood that preferably an array would comprise at least three, but preferably five, more preferably 10, even more preferably 25 and most preferably 61 of the genes of Table 65. However, it also appeared possible to classify on basis of genes, which did not occur in Table 5, but in such cases many genes are required to achieve an acceptable prediction. Thus, an array could also comprise at least 10, preferably 25, more preferably 50, and most preferably 100 of the genes of Table 5. 
         [0042]    As indicated above, various combinations of these genes can be used for determining the presence of lymph node metastases in several ways. 
         [0043]    On dual channel DNA microarrays this is performed by determining the expression level ratios of the genes in the primary tumour sample versus expression of the same genes in reference material. The reference material can be derived from a pool of total RNA or amplified mRNA from a set of HNSCC primary tumours with established lymph node metastasis characteristics. The individual gene expression ratios contribute towards the expression ratio signature of a sample. The degree of correlation of a sample&#39;s signature with the signatures of samples with known metastatic status (preferably calculated by the cosine correlation (Jones, W. P., &amp; Furnas, G. W. (1987). Pictures of Relevance: A Geometric Analysis of Similarity Measures. Journal of the American Society for Information Science, 36 (6), 420-442) as, e.g, provided by the Genesis software; http://genome.tugraz.at/Software/Genesis/Description.html) is used to predict the metastatic state of the unknown sample. The correlation threshold for predicting the metastatic state is based on the optimal threshold for discriminating between the metastatic states of the samples with known metastatic states, which can easily be determined by a person skilled in the art 
         [0044]    Other measurements of absolute expression and expression ratios of these genes can also be used. Reference material can be derived from other sources than a pool of samples with known metastatic states. Preferably, however, samples with known metastatic states are still required to determine the correlation threshold for determining the metastatic status. 
         [0045]    Expression ratios can also be derived from single channel microarray experiments, using as a reference so-called housekeeping genes (i.e. with stable expression across many different samples) or a collection of housekeeping genes or any collection of genes or features with stable expression. Again here it is preferred to use samples with known metastatic states to determine the correlation threshold for determining the metastatic status. 
         [0046]    Gene expression measurements and the derived ratios can also be obtained by (quantitative) reverse transcription PCR or any other assay for gene expression, using as a reference any gene or collection of genes that have stable expression across many samples. In a specific embodiment of this application of the invention, samples with known metastatic states are still required to determine the correlation threshold for determining the metastatic status. 
         [0047]    In the absence of tumour samples with known metastatic states for calibration of the prediction, the genes or various combinations of the (expression analysis of the) genes can still be used to predict the metastatic state. In these embodiments of the invention an absolute or relative measurement of gene expression is determined for example using single or dual channel DNA microarrays, or by other methods such as (quantitative) reverse transcription PCR. Increased expression of the genes in table 1 or 2 with a positive N+ correlation will hereby contribute positively towards prediction of the N+ status and negatively towards prediction of the N0 status. Conversely, increased expression of the genes in table 1 or 2 with a negative N+ correlation will contribute positively towards N0 prediction and negatively towards N+ prediction. Increased expression in both cases indicates an increase relative to a suitable marker gene or feature, set of genes or features or collectively in relation to each other. 
         [0048]    However, a person skilled in the art is able to obtain the reference data that have been produced in the below example, since this data is available as dataset E-UMCU-11 from the public micro-array database ArrayEcpress (http://www.ebi.ac.uk/arrayexpress/). When desiring to predict or determine the presence of metastases for a certain patient, the practitioner should take a biopsy from that patient, isolate the RNA and determine the expression of at least 5 of the elements of Table 1. To normalize these expression data with respect to the data of the reference set E-UMCU-11, it is possible to correct the data for variations with the help of expression data of a control gene or element which is not affected by the tumour state (such as a housekeeping gene), which is present in the reference set E-UMCU-11 and should also be available on the array that has been used to determine the expression profile of the patient to be assessed. In stead of one control gene or element, also the mean value of a poll of control genes or elements can be taken. This correction can, for instance, be done by subtracting the expression level of the control gene(s)/element(s) from the expression levels of each of the tested genes/elements. Preferably, the ratio for every tested gened with respect to the control gene(s) is calculated for both the patient&#39;s expression profile as well as for the expression data of the reference set. 
         [0049]    With these figures, the correlation with the mean value of the N0 values of the reference set should be calculated. If this correlation is negative (i.e. a value below zero) it can be concluded that the patient is N+ (i.e. having or prone to develop metastases). Conversely, the correlation can be calculated with respect to the mean value of the N+ values of the reference set. Then a negative correlation indicates a match with the N0 group. 
         [0050]    Further enablement for a diagnosis/prediction of cancer metastasis on basis of gene expression analyses can be found in WO 03/010337, indicating that methods as have been generally described above are well within the skills of the practitioners in the art. 
       EXAMPLE 
     Data Accessibility 
       [0051]    MIAME 1  compliant data in MAGE-ML 2  format as well as complete descriptions of protocols, microarrays and clinical parameters have been submitted to the public microarray database ArrayExpress (http://www.ebi.ac.uk/arrayexpress/) with the following accession numbers: Microarray layout, A-UMCU-3; HNSCC tumour data, E-UMCU-11; Protocols for sectioning of tumour material, P-UMCU-18; RNA isolation, P-UMCU-19; DNase treatment, P-UMCU-20; mRNA amplification, P-UMCU-21; generating reference pool, P-UMCU-26; cRNA labeling, P-UMCU-22; hybridization and washing of slides, P-UMCU-23 and P-UMCU-24; scanning of slides, P-UMCU-25; Image analysis, P-UMCU-11 
       Tumor Samples 
       [0052]    For the training set, 92 samples were randomly taken from a collection of primary tumours surgically removed between 1996 and 2000 and that fulfilled the following criteria: biopsy-proven HNSCC in the oropharynx and oral cavity; no previous malignancies in the head and neck region; tumour sections contained more than 50% tumour cells. Of these 92 tumours, 82 passed total RNA and cRNA quality control (QC) and were included in this study. For the validation set, 27 tumours were randomly taken from the same collection of tumours, surgically removed between 2000 and March 2001, and that fulfilled the same selection criteria. Of these, 22 passed total RNA and cRNA QC and were included in this study. The diagnostic procedures for clinical staging of cervical lymph nodes was performed according to the Netherlands national guidelines for oral cavity and oropharynx carcinomas, by clinical examination (palpation) of the neck region, followed by bilateral ultrasound examination, computed tomography (CT) and/or magnetic resonance imaging (MRI). Suspected nodes were subjected to aspiration cytology. In this way, patients were pre-operatively classified as either N0 or N+, the latter in the case of aspirates yielding metastatic tumour cells. Only in the case of obvious neck involvement, as shown by huge swelling, were the patients classified as N+ without additional efforts to prove the presence of metastasis. 
         [0053]    Surgery was aimed at complete tumour removal. With regard to the neck, in the case of clinical N0 only a SOHND was performed 3 . In cases clinically classified as N+ a RND was performed including all five lymph node levels 3 . Postoperative irradiation was administered in accordance with current practice and depending on margin status, tumour growth features, number of positive nodes and extracapsular growth. In practice, 36 out of 60 clinically assessed N0 patients and 38 out of 43 clinically assessed N+ patients received radiation therapy. This treatment as well as additional clinical information is presented in Supplemental data 2 (for accessibility, see above). After surgery, patients were periodically checked for development of neck metastasis, and patients initially classified as N0 but showing positive nodes in their surgical specimen or developing neck nodes within a time span of 3 years after surgery without having another head and neck cancer that could be responsible for this metastasis, were retrospectively added to the N+ patient group. Less than 5% of patients with HNSCC in the oral cavity or oropharynx subsequently develop metastasis after treatment 4,5 . Here, for the training and validation cohorts, one patient subsequently developed positive neck nodes after surgery. Three years is to be considered as a reliable time period, since at least 80% of the recurrences are known to take place in the first two years after surgery (Takes, R. P. et al. (2001) J Pathol 194, 298-302; Jones, K. R., et al., (1992) Arch. Otolaryngol. Head Neck Surg. 118, 483-485) 
         [0054]    Fresh tumour tissue was taken from the surgical specimen, snap-frozen in liquid nitrogen immediately after surgical removal and stored at −80° C. Frozen sections were cut for RNA isolation and immediately transferred to a RNAlater solution (Ambion). A haematoxylin and eosin stained section was prepared for tumour percentage assessment. Only samples with at least 50 percent tumour cells were used. For a small number of samples the tumour percentage was increased by removing areas with no tumour cells. 
       RNA Isolation 
       [0055]    Total RNA was isolated from 2-3 sections (20 μm) with TRIzol reagent (Invitrogen), followed by a purification using the RNeasy mini-kit (Qiagen) and a DNase treatment using the Qiagen DNA-free kit. The yield and quality of total RNA was checked by spectrophotometry and by the Agilent 2100 Bioanalyser (Agilent). Total RNA quality control criteria were in accordance with the Tumour Analysis Best Practices Working Group 6 , discarding samples with no clear 18S and 28S ribosomal bands. We also removed samples that had a yield lower than 500 ng total RNA or showed mycoplasma contamination. 
         [0000]    cRNA Synthesis and Labeling 
         [0056]    mRNA was amplified by in vitro transcription using T7 RNA polymerase on 1 μg of total RNA. First a double stranded cDNA template was generated including the T7 promoter. Next, this template was used for in vitro transcription with the T7 megascript kit (Ambion) to generate CRNA. During the in vitro transcription, 5-(3-aminoallyl)-UTP (Ambion) was incorporated into the single-stranded cRNA. The yield and quality of the cRNA was analyzed by spectrophotometry and by the Agilent 2100 Bioanalyser. Samples with a yield less than 5000 ng or with small cRNA fragments (median less than 500 bp) were not used. 
         [0057]    Cy3 or cy5 fluorophores (Amersham) were coupled to 500 ng of cRNA. After coupling, free dye molecules were removed using Clontech ChromoSpin-30 columns (Clontech). The yield and label incorporation (5-7%) of the cy-labeled cRNA was checked using spectrophotometry. Before hybridization, 300 ng of cy-labeled cRNA from one tumor was mixed with an equal amount of reverse color cy-labeled material from the reference sample. 
       Microarray Production 
       [0058]    The Human Array-Ready Oligo set (version 2.0) was purchased from Qiagen and printed on Corning UltraGAPS slides as described elsewhere 7 . The microarrays contained 70-mer oligonucleotides representing 21,329 genes as well as 3871 additional features for control purposes. 
       Microarray Hybridization 
       [0059]    Before use, the microarray slides were treated with sodium-borohydrate solution to reduce auto-fluorescence in the cy3-channel 8 . The labelled cRNA targets were hybridized on the microarray for 10 hours at 42° C. using the Ventana Discovery Hybridization Station in combination with the ChipMap-80 Kit (Ventana Europe). After hybridization the slides were manually washed and scanned in the Agilent G2565AA DNA Microarray Scanner (100% laser power, 30% PMT). 
       Pre-Processing of Expression Data 
       [0060]    The scanned images were quantified and background corrected using Imagene 4.0 software (Biodiscovery). The expression data was normalized for dye and print-tip biases using a Lowess per print-tip normalization algorithms applied in the statistical package R 10 . Following normalization, variance stabilization (VSN) 11  was applied to stabilize variance in the intensity data. Both duplicate dye-swap hybridizations of each tumour were averaged and for each gene a tumour-reference ratio was calculated. Reference versus reference hybridizations were used to build a gene error model for technical variation. Nine reference self-self comparisons were performed in dye-swap (18 hybridizations), resulting in nine reference ratios for each gene on the microarray. These nine reference ratios yield an estimate of the technical variation for each gene. To test whether a gene in a tumour samples shows differential expression, a Student&#39;s t-test was applied on the tumour ratio and the corresponding nine reference ratios (technical variation). The calculated p-values for differential expression were used to select those genes that show differential expression in the tumour samples. 
       Supervised Classification 
       [0061]    A classifier was constructed to distinguish between N0 and N+ patients. Of the 21,329 genes on the microarray, 6221 were excluded based on aberrant signal and spot morphology in one of the 164 hybridizations. From these remaining 15,108 genes, only genes that were significantly different from the reference in at least 31 tumours were selected based on the error model for technical variation (p&lt;0.01). This resulted in a set of 1,986 genes. For these genes the signal-to-noise-ratio (SNR) 12  was computed and employed to rank the genes (top ranked genes being genes that are best suited to distinguish the outcome classes). The optimal gene set to employ in the classifier (a nearest mean classifier similar to the classifier employed in 13 ), was determined by gradually expanding the gene set starting from the highest ranked gene. At each expansion round the nearest mean classifiers was trained on a training set and tested on a test set. The performance on the test set served as a quality measure of the gene set. The performance was measured as the average of the false positive (N0 classified as N+) and false negative (N+ classified as N0) rates of the test samples. Initially the performance increases as the set is expanded. The expansion of the gene set is terminated when the performance deteriorates, i.e. when the optimal performance is reached. The steps of ranking the genes and training and testing the classifier are performed in a 10-fold cross-validation procedure. The output of this procedure is an optimal number of top-ranked genes and a trained classifier. To ensure independent validation, this process of optimizing the set of genes and training the classifier is wrapped in a second 3-fold cross-validation loop. This entails that the optimization of the gene set and the training of the classifier is performed on ⅔ of the data, while the classifier is validated on ⅓ of the data. Since this ⅓ of the data is never involved in any of the gene selection and training steps, this ensures completely independent validation of the classifier, which avoids selection bias 14,15  and therefore results in a reliable performance estimate. This double-loop procedure determined 102 genes to form the final diagnostic classifier. This classifier was trained on the complete set of 82 samples by recalculating the signal-to-noise ratio for all genes and subsequently selecting the top 102 genes. The predictor was trained using the 102 selected genes and the 82 training samples. A decision threshold for this classifier was fixed such that the highest overall predictive accuracy for both N0 and N+ tumours. was reached. 
       Statistics 
       [0062]    Odds ratios (OR) were calculated by fitting a logistic regression model on the prediction outcome of the validation set. The predictor had an infinitive OR since no false negative prediction was made. To get an estimate of the OR for the predictor, one false negative was artificially introduced resulting in a predictor OR of 30 (p=0.006) and a clinical OR of 4.2 (p=0.15). The standard error for predictive accuracy ( FIG. 3   a ) includes the predictions made on the latter half of the training set. 
       Selection of Predictive Genes 
       [0063]    A multiple training approach was used to identify a complete set of predictive genes, based on the 66 tumor samples from 1998 to 2001. The tumor samples were randomly divided into a training set and test set using a 10-fold cross validation procedure. Based on the training set, P-values were calculated for all 3064 differentially expressed genes based on the difference in expression between N+ and N0 tumor samples (Student&#39;s T-test). The set of genes with lowest P-values (i.e. most-predictive) was used for prediction of the test samples by calculating the correlation with the average N+ and average N0 training profile and, based on these correlations, classifying the test samples as N0 or N+. Repeating this resampling procedure a thousand times resulted in multiple predictions for each tumor sample, based on the different predictive gene sets. This approach was repeated three times to determine 1000 predictive gene sets consisting of 50 genes, 1000 gene sets of 100 genes and 1000 gene sets of 200 genes. All gene sets had predictive value ( FIG. 1 ). Genes selected at least once are listed in Table 3. This consists of 825 genes with predictive power for detection or prediction of metastasis in head and neck squamous cell carcinoma. Small and large sets of genes from this list can be used for prediction ( FIG. 5 ). Genes selected more frequently, that is present in more than 50% of the 200 gene set predictors are listed in Table 4. This consists of 179 genes with strongest predictive power for detection or prediction of metastasis in head and neck squamous cell carcinoma. Small and large sets of genes from this list can be used for prediction. Genes selected most frequently (more than 90%) are listed in Table 5. This consists of 51 genes with the highest predictive power. Small and large sets of genes from this list can be used for prediction. This list consists of genes, most/all of which have never before been associated with prediction of metastasis in tumors, especially metastasis in head-neck squamous cell carcinoma. 
       REFERENCES 
       [0000]    
       
         1. Brazma, A. et al. Minimum information about a microarray experiment (MIAME)-toward standards for microarray data. Nat. Genet. 29, 365-371 (2001). 
         2. Spellman, P. T. et al. Design and implementation of microarray gene expression markup language (MAGE-ML). Genome Biol. 3, RESEARCH0046 (2002). 
         3. Robbins, K. T. et al. Neck dissection classification update: revisions proposed by the American Head and Neck Society and the American Academy of Otolaryngology-Head and Neck Surgery. Arch. Otolaryngol. Head Neck Surg. 128, 751-758 (2002). 
         4. Carvalho, A. L., Kowalski, L. P., Borges, J. A., Aguiar, S., Jr. &amp; Magrin, J. Ipsilateral neck cancer recurrences after elective supraomohyoid neck dissection. Arch. Otolaryngol. Head Neck Surg. 126, 410-412 (2000). 
         5. Ridge, J. A. Squamous cancer of the head and neck: surgical treatment of local and regional recurrence. Semin. Oncol. 20, 419-429 (1993). 
         6. Expression profiling-best practices for data generation and interpretation in clinical trials. Nat. Rev. Genet. 5, 229-237 (2004). 
         7. van de Peppel, J. et al. Monitoring global messenger RNA changes in externally controlled microarray experiments. EMBO Rep. 4, 387-393 (2003). 
         8. Raghavachari, N., Bao, Y. P., Li, G., Xie, X. &amp; Muller, U. R. Reduction of autofluorescence on DNA microarrays and slide surfaces by treatment with sodium borohydride. Anal. Biochem. 312, 101-105 (2003). 
         9. Yang, Y. H. et al. Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation. Nucleic Acids Res. 30, e15 (2002). 
         10. Ihaka, R. &amp; Gentleman, R. R: a language for data analysis and graphics. J. Comp. Graph. Statist. 5, 299-314 (1996). 
         11. Huber, W., von Heydebreck, A., Sultmann, H., Poustka, A. &amp; Vingron, M. Variance stabilization applied to microarray data calibration and to the quantification of differential expression. Bioinformatics 18 Suppl 1, S96-S104 (2002). 
         12. Golub, T. R. et al. Molecular classification of cancer: class discovery and class prediction by gene expression monitoring. Science 286, 531-537 (1999). 
         13. van &#39;t Veer, L. J. et al. Gene expression profiling predicts clinical outcome of breast cancer. Nature 415, 530-536 (2002). 
         14. Simon, R., Radmacher, M. D., Dobbin, K. &amp; McShane, L. M. Pitfalls in the use of DNA microarray data for diagnostic and prognostic classification. J. Natl. Cancer Inst. 95, 14-18 (2003). 
         15. Ambroise, C. &amp; McLachlan, G. J. Selection bias in gene extraction on the basis of microarray gene-expression data. Proc Natl Acad Sci USA 99, 6562-6566 (2002). 
       
     
         [0000]    
       
         
               
             
               
               
               
               
             
               
               
               
               
             
           
               
                 TABLE 1 
               
             
             
               
                   
               
               
                 Complete list of the 102 HNSCC predictor genes 
               
             
          
           
               
                 Gene 
                 GenBank ID 
                 Gene name 
                 N+ corr 
               
               
                   
               
             
          
           
               
                 FTH1 
                 NM_002032 
                 ferritin, heavy polypeptide 
                 0.726 
               
               
                   
                   
                 1 
               
               
                 COL5A1 
                 NM_000093 
                 COL5A1 protein (collagen 
                 0.627 
               
               
                   
                   
                 5 type A1 like) 
               
               
                 NCOR2 
                 NM_006312 
                 Nuclear receptor co- 
                 0.617 
               
               
                   
                   
                 repressor 2 
               
               
                 P4HA1 
                 NM_000917 
                 proline 4-hydroxylase 
                 0.572 
               
               
                   
                   
                 alpha polypeptide I 
               
               
                 TNFAIP3 
                 NM_006290 
                 tumour necrosis factor, 
                 0.536 
               
               
                   
                   
                 alpha-induced protein 3 
               
               
                 PLAU 
                 NM_002658 
                 urokinase plasminogen 
                 0.535 
               
               
                   
                   
                 activator (uPA) 
               
               
                 COL5A3 
                 NM_015719 
                 Collagen, type V, alpha 3 
                 0.521 
               
               
                 SPOCK 
                 NM_004598 
                 Sparc/osteonectin, cwcv 
                 0.500 
               
               
                   
                   
                 and kazal-like domains 
               
               
                   
                   
                 proteoglycan (testican) 
               
               
                 FAP 
                 NM_004460 
                 fibroblast activation 
                 0.498 
               
               
                   
                   
                 protein, alpha 
               
               
                 ADAM12 
                 NM_003474 
                 a disintegrin and 
                 0.482 
               
               
                   
                   
                 metalloproteinase domain 
               
               
                   
                   
                 12 (meltrin alpha) 
               
               
                 TPM2 
                 NM_003289 
                 tropomyosin 2 (beta) 
                 0.470 
               
               
                 MICAL2 
                 NM_014632 
                 flavoprotein 
                 0.459 
               
               
                   
                   
                 oxidoreductase MICAL2 
               
               
                 D2S448 
                 XM_056455 
                 D2S448 (Melanoma 
                 0.446 
               
               
                   
                   
                 associated gene) 
               
               
                 PAI-1 
                 NM_000602 
                 plasminogen activator 
                 0.440 
               
               
                   
                   
                 inhibitor type 1 
               
               
                 REN 
                 NM_000537 
                 renin 
                 0.383 
               
               
                 POSTN 
                 NM_006475 
                 periostin, osteoblast 
                 0.367 
               
               
                   
                   
                 specific factor 
               
               
                 CKTSF1B1 
                 NM_013372 
                 cysteine knot superfamily 
                 0.330 
               
               
                   
                   
                 1, BMP antagonist 1 
               
               
                   
                   
                 (DRM/GREMLIN) 
               
               
                 IER3 
                 NM_003897 
                 immediate early response 
                 0.303 
               
               
                   
                   
                 3 
               
               
                 MMD 
                 NM_012329 
                 monocyte to macrophage 
                 0.300 
               
               
                   
                   
                 differentiation-associated 
               
               
                 CTDSP1 
                 NM_021198 
                 CTD (carboxy-terminal 
                 0.260 
               
               
                   
                   
                 domain, RNA polymerase 
               
               
                   
                   
                 II, polypeptide A) small 
               
               
                   
                   
                 phosphatase 1 
               
               
                 PSMD2 
                 NM_002808 
                 proteasome (prosome, 
                 0.256 
               
               
                   
                   
                 macropain) 26S subunit, 
               
               
                   
                   
                 non-ATPase, 2 
               
               
                 MAN1B1 
                 NM_016219 
                 mannosidase, alpha, class 
                 0.254 
               
               
                   
                   
                 1B, member 1 
               
               
                 DKK3 
                 NM_013253 
                 dickkopf homolog 3 
                 0.140 
               
               
                   
                   
                 ( Xenopus laevis ) 
               
               
                 NT5C3 
                 NM_016489 
                 5′-nucleotidase, cytosolic 
                 0.138 
               
               
                   
                   
                 III 
               
               
                 DAPK3 
                 NM_001348 
                 death-associated protein 
                 0.022 
               
               
                   
                   
                 kinase 3 
               
               
                 NDUFB4 
                 NM_004547 
                 NADH dehydrogenase 
                 0.012 
               
               
                   
                   
                 (ubiquinone) 1 beta 
               
               
                   
                   
                 subcomplex, 4, 15 kDa 
               
               
                 UBA52 
                 NM_003333 
                 ubiquitin A-52 residue 
                 −0.002 
               
               
                   
                   
                 ribosomal protein fusion 
               
               
                   
                   
                 product 1 
               
               
                 C9orf5 
                 NM_032012 
                 chromosome 9 open 
                 −0.075 
               
               
                   
                   
                 reading frame 5 
               
               
                 COPG 
                 NM_016128 
                 Coat protein gamma-cop 
                 −0.081 
               
               
                 RGS5 
                 NM_003617 
                 regulator of G-protein 
                 −0.097 
               
               
                   
                   
                 signalling 5 
               
               
                 FLJ12236 
                 AK022298 
                   Homo sapiens  cDNA 
                 −0.104 
               
               
                   
                   
                 FLJ12236 fis, clone 
               
               
                   
                   
                 MAMMA1001244 
               
               
                 IDI1 
                 NM_004508 
                 Isopentenyl-diphosphate 
                 −0.126 
               
               
                   
                   
                 delta isomerase 
               
               
                 RPL37A 
                 NM_000998 
                 ribosomal protein L37a 
                 −0.162 
               
               
                 ZDHHC18 
                 NM_032283 
                 Zinc finger DHHC domain 
                 −0.175 
               
               
                   
                   
                 containing protein 18 
               
               
                 MO30 
                 M26463 
                 
                   Homo sapiens 
                 
                 −0.194 
               
               
                   
                   
                 immunoglobulin mu chain 
               
               
                   
                   
                 antibody MO30 (IgM) 
               
               
                   
                   
                 mRNA, complete cds 
               
               
                 FLJ20073 
                 NM_017654 
                 Hypothetical protein 
                 −0.215 
               
               
                   
                   
                 FLJ20073 
               
               
                 FLJ30814 
                 AK055376 
                   Homo sapiens  cDNA 
                 −0.222 
               
               
                   
                   
                 FLJ30814 fis, clone 
               
               
                   
                   
                 FEBRA2001529 
               
               
                 PLK2 
                 NM_006622 
                 polo-like kinase 2 
                 −0.230 
               
               
                 MMPL1 
                 NM_004142 
                 Matrix metalloproteinase- 
                 −0.230 
               
               
                   
                   
                 like 1 
               
               
                   
                 Z95126 
                 Human DNA sequence 
                 −0.232 
               
               
                   
                   
                 from clone RP1-30P20 on 
               
               
                   
                   
                 chromosome Xq21.1-21.3 
               
               
                 BAL 
                 NM_031458 
                 B aggressive lymphoma 
                 −0.234 
               
               
                   
                   
                 protein (BAL) 
               
               
                 OSBP2 
                 NM_030758 
                 Oxysterol binding protein 
                 −0.244 
               
               
                   
                   
                 2 
               
               
                 PARVB 
                 NM_013327 
                 Parvin, beta 
                 −0.286 
               
               
                 CEBPA 
                 NM_004364 
                 CCAAT/enhancer binding 
                 −0.290 
               
               
                   
                   
                 protein (C/EBP), alpha 
               
               
                 ZNF533 
                 NM_152520 
                 zinc finger protein 533 
                 −0.291 
               
               
                 ABCA12 
                 NM_015657 
                 ATP-binding cassette, sub- 
                 −0.293 
               
               
                   
                   
                 family A (ABC1), member 
               
               
                   
                   
                 12 
               
               
                 LOR 
                 NM_000427 
                 loricrin 
                 −0.322 
               
               
                 E2F5 
                 NM_001951 
                 E2F transcription factor 5, 
                 −0.356 
               
               
                   
                   
                 p130-binding 
               
               
                 APM2 
                 NM_006829 
                 Adipose specific 2 
                 −0.360 
               
               
                 CAPNS2 
                 NM_032330 
                 CAPNS2 (calpain small 
                 −0.360 
               
               
                   
                   
                 subunit 2) 
               
               
                 MGC13219 
                 NM_032931 
                 Hypothetical protein 
                 −0.367 
               
               
                   
                   
                 MGC13219 
               
               
                 FLJ22202 
                 NM_024883 
                 Hypothetical protein 
                 −0.383 
               
               
                   
                   
                 FLJ22202 
               
               
                 KRT23 
                 NM_173213 
                 keratin 23 (histone 
                 −0.409 
               
               
                   
                   
                 deacetylase inducible) 
               
               
                 PPT2 
                 NM_005155 
                 palmitoyl-protein 
                 −0.417 
               
               
                   
                   
                 thioesterase 2 
               
               
                 PGBD5 
                 NM_024554 
                 piggyBac transposable 
                 −0.469 
               
               
                   
                   
                 element derived 5 
               
               
                 SSH2 
                 NM_033389 
                 SSH2 (slingshot 2) 
                 −0.475 
               
               
                 ALOX12B 
                 NM_001139 
                 arachidonate 12- 
                 −0.480 
               
               
                   
                   
                 lipoxygenase, 12R type 
               
               
                 MAL2 
                 NM_052886 
                 mal, T-cell differentiation 
                 −0.544 
               
               
                   
                   
                 protein 2 
               
               
                 ZD52F1 
                 NM_033317 
                 Hypothetical gene ZD52F1 
                 −0.562 
               
               
                 EPPK1 
                 AB107036 
                 Epiplakin 1 
                 −0.566 
               
               
                 S100A7 
                 NM_002963 
                 S100 calcium binding 
                 −0.580 
               
               
                   
                   
                 protein A7 (psoriasin 1) 
               
               
                 FLJ22184 
                 NM_025094 
                 Hypothetical protein 
                 −0.586 
               
               
                   
                   
                 FLJ22184 
               
               
                 MAP17 
                 NM_005764 
                 membrane-associated 
                 −0.591 
               
               
                   
                   
                 protein 17 (MAP17) 
               
               
                 FLJ13497 
                 AK023559 
                   Homo sapiens  cDNA 
                 −0.603 
               
               
                   
                   
                 FLJ13497 fis, clone 
               
               
                   
                   
                 PLACE14518 
               
               
                 ECM1 
                 NM_022664 
                 extracellular matrix 
                 −0.610 
               
               
                   
                   
                 protein 1 
               
               
                 TGM3 
                 NM_003245 
                 transglutaminase 3 (E 
                 −0.629 
               
               
                   
                   
                 polypeptide, protein- 
               
               
                   
                   
                 glutamine-gamma- 
               
               
                   
                   
                 glutamyltransferase) 
               
               
                 RAD17 
                 NM_133344 
                 RAD 17 homolog ( S.   
                 −0.631 
               
               
                   
                   
                   pombe ) 
               
               
                 FLJ30988 
                 AK055550 
                   Homo sapiens  cDNA 
                 −0.650 
               
               
                   
                   
                 FLJ30988 fis, clone 
               
               
                   
                   
                 HLUNG1000030 
               
               
                 C10orf26 
                 NM_017787 
                 chromosome 10 open 
                 −0.653 
               
               
                   
                   
                 reading frame 26 
               
               
                 PALM2 
                 NM_053016 
                 paralemmin 2 
                 −0.655 
               
               
                 C4.4A 
                 NM_014400 
                 GPI-anchored metastasis- 
                 −0.665 
               
               
                   
                   
                 associated protein homolog 
               
               
                   
                   
                 (C4.4A) 
               
               
                 ECG2 
                 NM_032566 
                 Esophagus cancer-related 
                 −0.670 
               
               
                   
                   
                 gene-2 protein precursor 
               
               
                   
                   
                 (ECRG-2) 
               
               
                 PPL 
                 NM_002705 
                 periplakin 
                 −0.672 
               
               
                 HPCAL1 
                 NM_002149 
                 hippocalcin-like 1 
                 −0.674 
               
               
                 SLPI 
                 NM_003064 
                 secretory leukocyte 
                 −0.677 
               
               
                   
                   
                 protease inhibitor 
               
               
                   
                   
                 (antileukoproteinase) 
               
               
                 PI3 
                 NM_002638 
                 protease inhibitor 3, skin- 
                 −0.680 
               
               
                   
                   
                 derived (SKALP) 
               
               
                 FLJ25911 
                 AK098777 
                 Hypothetical protein 
                 −0.680 
               
               
                   
                   
                 FLJ25911 [Fragment] 
               
               
                 CLIC3 
                 NM_004669 
                 chloride intracellular 
                 −0.691 
               
               
                   
                   
                 channel 3 
               
               
                 BENE 
                 NM_005434 
                 BENE protein 
                 −0.698 
               
               
                 FLJ00074 
                 AK024480 
                 FLJ00074 protein 
                 −0.699 
               
               
                   
                   
                 [Fragment] 
               
               
                 DKFZp547F 
                 AL512697 
                   Homo sapiens  mRNA; 
                 −0.706 
               
               
                 134 
                   
                 cDNA DKFZp547F134 
               
               
                   
                   
                 (from clone 
               
               
                   
                   
                 DKFZp547F134) 
               
               
                 PLA2G4B 
                 NM_005090 
                 phospholipase A2, group 
                 −0.707 
               
               
                   
                   
                 IVB (cytosolic) 
               
               
                   
                 AF339799 
                   Homo sapiens  clone 
                 −0.708 
               
               
                   
                   
                 IMAGE: 2363394, mRNA 
               
               
                   
                   
                 sequence 
               
               
                 TRGV9 
                 BC062761 
                 T cell receptor gamma 
                 −0.710 
               
               
                   
                   
                 variable 9 
               
               
                 DSG3 
                 NM_001944 
                 desmoglein 3 (pemphigus 
                 −0.711 
               
               
                   
                   
                 vulgaris antigen) 
               
               
                 FLJ12787 
                 NM_032175 
                 Hypothetical protein 
                 −0.734 
               
               
                   
                   
                 FLJ12787 
               
               
                 LLGL2 
                 NM_004524 
                 lethal giant larvae 
                 −0.738 
               
               
                   
                   
                 homolog 2 ( Drosophila ) 
               
               
                 SMC5L1 
                 NM_015110 
                 SMC5 structural 
                 −0.741 
               
               
                   
                   
                 maintenance of 
               
               
                   
                   
                 chromosomes 5-like 1 
               
               
                 ODCP 
                 NM_052998 
                 Ornithine decarboxylase- 
                 −0.741 
               
               
                   
                   
                 like protein (EC 4.1.1.17) 
               
               
                   
                   
                 (ODC-paralogue) (ODC-p) 
               
               
                 FLJ31161 
                 AK055723 
                   Homo sapiens  cDNA 
                 −0.747 
               
               
                   
                   
                 FLJ31161 fis, clone 
               
               
                   
                   
                 KIDNE1000028 
               
               
                 FLJ21214 
                 AK024867 
                   Homo sapiens  cDNA: 
                 −0.748 
               
               
                   
                   
                 FLJ21214 fis, clone 
               
               
                   
                   
                 COL00523 
               
               
                 SPINK5 
                 NM_006846 
                 serine protease inhibitor, 
                 −0.749 
               
               
                   
                   
                 Kazal type, 5 
               
               
                 KIAA0350 
                 XM_290667 
                 KIAA0350 protein 
                 −0.760 
               
               
                 PGLYRPL 
                 NM_052890 
                 peptidoglycan recognition 
                 −0.764 
               
               
                   
                   
                 protein L precursor 
               
               
                 S100A9 
                 NM_002965 
                 S100 calcium binding 
                 −0.773 
               
               
                   
                   
                 protein A9 (calgranulin B) 
               
               
                 DNAH11 
                 NM_003777 
                 Dynein, axonemal, heavy 
                 −0.776 
               
               
                   
                   
                 chain-11 
               
               
                 LAGY 
                 NM_032495 
                 lung cancer-associated Y 
                 −0.793 
               
               
                   
                   
                 protein; homeodomain- 
               
               
                   
                   
                 only protein 
               
               
                 IVL 
                 NM_005547 
                 involucrin 
                 −0.801 
               
               
                 TNFRSF5 
                 NM_001250 
                 tumor necrosis factor 
                 −0.802 
               
               
                   
                   
                 receptor superfamily, 
               
               
                   
                   
                 member 5 (CD40) 
               
               
                 SRP19 
                 NM_003135 
                 signal recognition particle 
                 −0.814 
               
               
                   
                   
                 19 kDa 
               
               
                 KLK12 
                 NM_019598 
                 kallikrein 12 
                 −0.837 
               
               
                 IL22RA1 
                 NM_021258 
                 interleukin 22 receptor, 
                 −0.885 
               
               
                   
                   
                 alpha 1 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
               
               
               
               
             
           
               
                 TABLE 2 
               
               
                   
               
               
                 Gene 
                 GenBank ID 
                 Gene name 
                 N+ corr. 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                 COL5A3 
                 NM_015719 
                 Collagen, type V, alpha 3 
                 0.520719 
               
               
                 COL5A1 
                 NM_000093 
                 COL5A1 protein (collagen 5 
                 0.626949 
               
               
                   
                   
                 type A1 like) 
               
               
                 ZD52F1 
                 NM_033317 
                 Hypothetical gene ZD52F1 
                 −0.56185 
               
               
                 FLJ25911 
                 AK098777 
                 Hypothetical protein FLJ25911 
                 −0.6799 
               
               
                   
                   
                 [Fragment] 
               
               
                 EPPK1 
                 AB107036 
                 Epiplakin 1 
                 −6.56641 
               
               
                 KIAA0350 
                 XM_290667 
                 KIAA0350 protein 
                 −0.76021 
               
               
                 DNAH11 
                 NM_003777 
                 Dynein, axonemal, heavy 
                 −0.77599 
               
               
                   
                   
                 chain-11 
               
               
                 PI3 
                 NM_002638 
                 protease inhibitor 3, skin- 
                 −0.67983 
               
               
                   
                   
                 derived (SKALP) 
               
               
                 P4HA1 
                 NM_000917 
                 procollagen-proline, 
                 0.572479 
               
               
                   
                   
                 2-oxoglutarate 4-dioxygenase 
               
               
                   
                   
                 (proline 4-hydroxylase), 
               
               
                   
                   
                 alpha polypeptide I 
               
               
                 ODCP 
                 NM_052998 
                 Ornithine decarboxylase-like 
                 −0.74146 
               
               
                   
                   
                 protein (EC 4.1.1.17) (ODC- 
               
               
                   
                   
                 paralogue) (ODC-p) 
               
               
                 MMD 
                 NM_012329 
                 monocyte to macrophage 
                 0.299881 
               
               
                   
                   
                 differentiation-associated 
               
               
                 TPM2 
                 NM_003289 
                 tropomyosin 2 (beta) 
                 0.470038 
               
               
                 SRP19 
                 NM_003135 
                 signal recognition particle 
                 −0.81361 
               
               
                   
                   
                 19 kDa 
               
               
                 IL22RA1 
                 NM_021258 
                 interleukin 22 receptor, 
                 −0.88482 
               
               
                   
                   
                 alpha 1 
               
               
                 FLJ31161 
                 AK055723 
                   Homo sapiens  cDNA FLJ31161 
                 −0.7475 
               
               
                   
                   
                 fis, clone KIDNE1000028 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
               
               
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 3 
               
             
             
               
                   
               
               
                 List of 825 genes with predictive value 
               
             
          
           
               
                   
                   
                   
                   
                 N+ 
                   
               
               
                 UniProt 
                 Gene_symbol 
                 GB_accession 
                 UniGene_ID 
                 correlation 
                 Gene 
               
               
                   
               
             
          
           
               
                 Q9NZQ6 
                 COL5A3 
                 NM_015719 
                 235368 
                 0.57481098 
                 Collagen, type V, alpha 3 
               
               
                 FINC_HUMAN 
                 FN1 
                 NM_002026 
                 287820 
                 0.55126846 
                 Fibronectin 1 
               
               
                 FSL1_HUMAN 
                 FSTL1 
                 NM_007085 
                 296267 
                 0.53452734 
                 Follistatin-like 1 
               
               
                 ER22_HUMAN 
                 KDELR2 
                 NM_006854 
                 118778 
                 0.52986731 
                 KDEL (Lys-Asp-Glu- 
               
               
                   
                   
                   
                   
                   
                 Leu) endoplasmic 
               
               
                   
                   
                   
                   
                   
                 reticulum protein 
               
               
                   
                   
                   
                   
                   
                 retention receptor 2 
               
               
                 PCO1_HUMAN 
                 PCOLCE 
                 NM_002593 
                 202097 
                 0.52672595 
                 Procollagen C- 
               
               
                   
                   
                   
                   
                   
                 endopeptidase 
               
               
                   
                   
                   
                   
                   
                 enhancer 
               
               
                 SPRC_HUMAN 
                 SPARC 
                 NM_003118 
                 111779 
                 0.51922531 
                 Secreted protein, 
               
               
                   
                   
                   
                   
                   
                 acidic, cysteine-rich 
               
               
                   
                   
                   
                   
                   
                 (osteonectin) 
               
               
                 NC5R_HUMAN 
                 DIA1 
                 NM_007326 
                 274464 
                 0.51482855 
                 Diaphorase (NADH) 
               
               
                   
                   
                   
                   
                   
                 (cytochrome b-5 
               
               
                   
                   
                   
                   
                   
                 reductase) 
               
               
                 SEPR_HUMAN 
                 FAP 
                 NM_004460 
                 418 
                 0.51466336 
                 Fibroblast activation 
               
               
                   
                   
                   
                   
                   
                 protein, alpha 
               
               
                 HSAC013564 
                 COL5A1 
                 NM_000093 
                 146428 
                 0.51225806 
                 Collagen, type V, alpha 1 
               
               
                 HSAC009848 
                 ZFP93 
                 NM_004234 
                 298089 
                 0.50989391 
                 Zinc finger protein 93 
               
               
                   
                   
                   
                   
                   
                 homolog (mouse) 
               
               
                 PGCV_HUMAN 
                 CSPG2 
                 U16306 
                 81800 
                 0.50906177 
                 Chondroitin sulfate 
               
               
                   
                   
                   
                   
                   
                 proteoglycan 2 
               
               
                   
                   
                   
                   
                   
                 (versican) 
               
               
                 Q14521 
                 LLGL2 
                 NM_004524 
                 3123 
                 −0.50695888 
                 Lethal giant larvae 
               
               
                   
                   
                   
                   
                   
                 homolog 2 ( Drosophila ) 
               
               
                 CA14_HUMAN 
                 COL4A1 
                 NM_001845 
                 119129 
                 0.50664753 
                 Collagen, type IV, 
               
               
                   
                   
                   
                   
                   
                 alpha 1 
               
               
                 HSAC014709 
                 TEM1 
                 NM_020404 
                 195727 
                 0.50647843 
                 Tumor endothelial 
               
               
                   
                   
                   
                   
                   
                 marker 1 precursor 
               
               
                 UROK_HUMAN 
                 PLAU 
                 NM_002658 
                 77274 
                 0.50439834 
                 Plasminogen activator, 
               
               
                   
                   
                   
                   
                   
                 urokinase 
               
               
                 Q8N6P7 
                 IL22R 
                 NM_021258 
                 110915 
                 −0.49928496 
                 Interleukin 22 receptor 
               
               
                 LEG1_HUMAN 
                 LGALS1 
                 NM_002305 
                 227751 
                 0.48740219 
                 Lectin, galactoside- 
               
               
                   
                   
                   
                   
                   
                 binding, soluble, 1 
               
               
                   
                   
                   
                   
                   
                 (galectin 1) 
               
               
                 CA25_HUMAN 
                 COL5A2 
                 NM_000393 
                 82985 
                 0.48675513 
                 Collagen, type V, alpha 2 
               
               
                 CA13_HUMAN 
                 COL3A1 
                 NM_000090 
                 119571 
                 0.48459913 
                 Collagen, type III, 
               
               
                   
                   
                   
                   
                   
                 alpha 1 (Ehlers-Danlos 
               
               
                   
                   
                   
                   
                   
                 syndrome type IV, 
               
               
                   
                   
                   
                   
                   
                 autosomal dominant) 
               
               
                 Q9BYD5 
                 LOC84518 
                 NM_032488 
                 148590 
                 −0.48449285 
                 Protein related with 
               
               
                   
                   
                   
                   
                   
                 psoriasis 
               
               
                 BGH3_HUMAN 
                 TGFBI 
                 NM_000358 
                 118787 
                 0.48290139 
                 Transforming growth 
               
               
                   
                   
                   
                   
                   
                 factor, beta-induced, 
               
               
                   
                   
                   
                   
                   
                 68 kD 
               
               
                 CQT6_HUMAN 
                 CTRP6 
                 NM_031910 
                 22011 
                 0.47978614 
                 Complement-c1q tumor 
               
               
                   
                   
                   
                   
                   
                 necrosis factor-related 
               
               
                   
                   
                   
                   
                   
                 protein 6 
               
               
                 AD12_HUMAN 
                 ADAM12 
                 NM_003474 
                 8850 
                 0.47905457 
                 A disintegrin and 
               
               
                   
                   
                   
                   
                   
                 metalloproteinase 
               
               
                   
                   
                   
                   
                   
                 domain 12 (meltrin 
               
               
                   
                   
                   
                   
                   
                 alpha) 
               
               
                 Q8N3N2 
                 FLJ11196 
                 NM_018357 
                 6166 
                 0.47772636 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ11196 
               
               
                 CATK_HUMAN 
                 CTSK 
                 NM_000396 
                 83942 
                 0.47734967 
                 Cathepsin K 
               
               
                   
                   
                   
                   
                   
                 (pycnodysostosis) 
               
               
                 Q96DR2 
                 0 
                 AK055031 
                 44289 
                 −0.47659518 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ30469 fis, clone 
               
               
                   
                   
                   
                   
                   
                 BRAWH1000037, 
               
               
                   
                   
                   
                   
                   
                 weakly similar to 
               
               
                   
                   
                   
                   
                   
                 UROKINASE 
               
               
                   
                   
                   
                   
                   
                 PLASMINOGEN 
               
               
                   
                   
                   
                   
                   
                 ACTIVATO 
               
               
                 P03996 
                 ACTA2 
                 NM_001613 
                 195851 
                 0.47560995 
                 Actin, alpha 2, smooth 
               
               
                   
                   
                   
                   
                   
                 muscle, aorta 
               
               
                 K6A2_HUMAN 
                 0 
                 AK027727 
                 184581 
                 0.47396182 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ14821 fis, clone 
               
               
                   
                   
                   
                   
                   
                 OVARC1000556, 
               
               
                   
                   
                   
                   
                   
                 highly similar to 
               
               
                   
                   
                   
                   
                   
                 RIBOSOMAL 
               
               
                   
                   
                   
                   
                   
                 PROTEIN S6 KINASE 
               
               
                   
                   
                   
                   
                   
                 II 
               
               
                 Q9HBB0 
                 THY1 
                 AK057865 
                 125359 
                 0.4727028 
                 Thy-1 cell surface 
               
               
                   
                   
                   
                   
                   
                 antigen 
               
               
                 TM29_HUMAN 
                 TRIM29 
                 NM_012101 
                 82237 
                 −0.47250994 
                 Tripartite motif- 
               
               
                   
                   
                   
                   
                   
                 containing 29 
               
               
                 TIM2_HUMAN 
                 0 
                 AL110197 
                 6441 
                 0.47199573 
                   Homo sapiens  mRNA; 
               
               
                   
                   
                   
                   
                   
                 cDNA DKFZp586J021 
               
               
                   
                   
                   
                   
                   
                 (from clone 
               
               
                   
                   
                   
                   
                   
                 DKFZp586J021) 
               
               
                 MM02_HUMAN 
                 MMP2 
                 NM_004530 
                 111301 
                 0.47026319 
                 Matrix 
               
               
                   
                   
                   
                   
                   
                 metalloproteinase 2 
               
               
                   
                   
                   
                   
                   
                 (gelatinase A, 72 kD 
               
               
                   
                   
                   
                   
                   
                 gelatinase, 72 kD type 
               
               
                   
                   
                   
                   
                   
                 IV collagenase) 
               
               
                 MCA2_HUMAN 
                 JTV1 
                 NM_006303 
                 301613 
                 0.46964142 
                 JTV1 gene 
               
               
                 CA16_HUMAN 
                 COL6A1 
                 NM_001848 
                 108885 
                 0.46942561 
                 Collagen, type VI, 
               
               
                   
                   
                   
                   
                   
                 alpha 1 
               
               
                 EVA1_HUMAN 
                 EVA1 
                 AF275945 
                 116651 
                 −0.4689165 
                 Epithelial V-like antigen 1 
               
               
                 CA21_HUMAN 
                 COL1A2 
                 NM_000089 
                 179573 
                 0.46739585 
                 Collagen, type I, alpha 2 
               
               
                 CA36_HUMAN 
                 COL6A3 
                 NM_004369 
                 80988 
                 0.46507048 
                 Collagen, type VI, 
               
               
                   
                   
                   
                   
                   
                 alpha 3 
               
               
                 OPN3_HUMAN 
                 OPN3 
                 NM_014322 
                 279926 
                 0.46101056 
                 Opsin 3 
               
               
                   
                   
                   
                   
                   
                 (encephalopsin, 
               
               
                   
                   
                   
                   
                   
                 panopsin) 
               
               
                 Q9UBG0 
                 KIAA0709 
                 NM_006039 
                 7835 
                 0.46012143 
                 Endocytic receptor 
               
               
                   
                   
                   
                   
                   
                 (macrophage mannose 
               
               
                   
                   
                   
                   
                   
                 receptor family) 
               
               
                 TPM2_HUMAN 
                 TPM2 
                 NM_003289 
                 300772 
                 0.46003075 
                 Tropomyosin 2 (beta) 
               
               
                 INVO_HUMAN 
                 IVL 
                 NM_005547 
                 157091 
                 −0.45860578 
                 Involucrin 
               
               
                 O88386 
                 RAB10 
                 NM_016131 
                 236494 
                 −0.45006586 
                 RAB10, member RAS 
               
               
                   
                   
                   
                   
                   
                 oncogene family 
               
               
                 PEPL_HUMAN 
                 PPL 
                 NM_002705 
                 74304 
                 −0.44874989 
                 Periplakin 
               
               
                 HSAC002603 
                 FLJ11036 
                 NM_018306 
                 16740 
                 −0.44841185 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ11036 
               
               
                 TNR5_HUMAN 
                 TNFRSF5 
                 NM_001250 
                 25648 
                 −0.44547341 
                 Tumor necrosis factor 
               
               
                   
                   
                   
                   
                   
                 receptor superfamily, 
               
               
                   
                   
                   
                   
                   
                 member 5 
               
               
                 FRIH_HUMAN 
                 FTH1 
                 AK054816 
                 62954 
                 0.4396982 
                 Ferritin, heavy 
               
               
                   
                   
                   
                   
                   
                 polypeptide 1 
               
               
                 P4H2_HUMAN 
                 P4HA2 
                 NM_004199 
                 3622 
                 0.42478412 
                 Procollagen-proline, 2- 
               
               
                   
                   
                   
                   
                   
                 oxoglutarate 4- 
               
               
                   
                   
                   
                   
                   
                 dioxygenase (proline 4- 
               
               
                   
                   
                   
                   
                   
                 hydroxylase), alpha 
               
               
                   
                   
                   
                   
                   
                 polypeptide II 
               
               
                 P09526 
                 RAP1B 
                 NM_015646 
                 156764 
                 0.42234208 
                 RAP1B, member of 
               
               
                   
                   
                   
                   
                   
                 RAS oncogene family 
               
               
                 PS23_HUMAN 
                 SPUVE 
                 NM_007173 
                 25338 
                 0.42080095 
                 Protease, serine, 23 
               
               
                 HSAC011159 
                 0 
                 AF009267 
                 102238 
                 −0.46560322 
                   Homo sapiens  clone 
               
               
                   
                   
                   
                   
                   
                 FBA1 Cri-du-chat 
               
               
                   
                   
                   
                   
                   
                 region mRNA 
               
               
                 SDC2_HUMAN 
                 SDC2 
                 J04621 
                 1501 
                 0.45455196 
                 Syndecan 2 (heparan 
               
               
                   
                   
                   
                   
                   
                 sulfate proteoglycan 1, 
               
               
                   
                   
                   
                   
                   
                 cell surface-associated, 
               
               
                   
                   
                   
                   
                   
                 fibroglycan) 
               
               
                 HSAC013320 
                 0 
                 AL162069 
                 140978 
                 −0.44362782 
                   Homo sapiens  mRNA; 
               
               
                   
                   
                   
                   
                   
                 cDNA DKFZp762H106 
               
               
                   
                   
                   
                   
                   
                 (from clone 
               
               
                   
                   
                   
                   
                   
                 DKFZp762H106) 
               
               
                 TAGL_HUMAN 
                 TAGLN 
                 NM_003186 
                 75777 
                 0.4376112 
                 Transgelin 
               
               
                 MM01_HUMAN 
                 MMP1 
                 NM_002421 
                 83169 
                 0.4326825 
                 Matrix 
               
               
                   
                   
                   
                   
                   
                 metalloproteinase 1 
               
               
                   
                   
                   
                   
                   
                 (interstitial 
               
               
                   
                   
                   
                   
                   
                 collagenase) 
               
               
                 P05209 
                 K-ALPHA-1 
                 NM_006082 
                 334842 
                 0.42236541 
                 Tubulin, alpha, 
               
               
                   
                   
                   
                   
                   
                 ubiquitous 
               
               
                 TSP2_HUMAN 
                 THBS2 
                 NM_003247 
                 108623 
                 0.46791583 
                 Thrombospondin 2 
               
               
                 Q8N789 
                 DKFZP434K0410 
                 AL137589 
                 152149 
                 −0.43787021 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 DKFZp434K0410 
               
               
                 O60335 
                 KIAA0594 
                 AB011166 
                 103283 
                 −0.42578156 
                 KIAA0594 protein 
               
               
                 P05209 
                 K-ALPHA-1 
                 NM_006082 
                 334842 
                 0.42277793 
                 Tubulin, alpha, 
               
               
                   
                   
                   
                   
                   
                 ubiquitous 
               
               
                 TNI3_HUMAN 
                 TNFAIP3 
                 NM_006290 
                 211600 
                 0.408128 
                 Tumor necrosis factor, 
               
               
                   
                   
                   
                   
                   
                 alpha-induced protein 3 
               
               
                 FGR1_HUMAN 
                 FGFR1 
                 NM_023109 
                 748 
                 0.43553561 
                 Fibroblast growth factor 
               
               
                   
                   
                   
                   
                   
                 receptor 1 (fms-related 
               
               
                   
                   
                   
                   
                   
                 tyrosine kinase 2, 
               
               
                   
                   
                   
                   
                   
                 Pfeiffer syndrome) 
               
               
                 CAD2_HUMAN 
                 CDH2 
                 NM_001792 
                 161 
                 0.3922152 
                 Cadherin 2, type 1, N- 
               
               
                   
                   
                   
                   
                   
                 cadherin (neuronal) 
               
               
                 TCOF_HUMAN 
                 TCOF1 
                 NM_000356 
                 301266 
                 0.38956707 
                 Treacher Collins- 
               
               
                   
                   
                   
                   
                   
                 Franceschetti 
               
               
                   
                   
                   
                   
                   
                 syndrome 1 
               
               
                 O14635 
                 0 
                 AF005082 
                 113261 
                 −0.45637623 
                   Homo sapiens  skin- 
               
               
                   
                   
                   
                   
                   
                 specific protein (xp33) 
               
               
                   
                   
                   
                   
                   
                 mRNA, partial cds 
               
               
                 GLSK_HUMAN 
                 GLS 
                 NM_014905 
                 239189 
                 0.43214995 
                 Glutaminase 
               
               
                 Q9BRJ6 
                 MGC11257 
                 NM_032350 
                 334368 
                 0.42954566 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 MGC11257 
               
               
                 ALK1_HUMAN 
                 SLPI 
                 NM_003064 
                 251754 
                 −0.41872706 
                 Secretory leukocyte 
               
               
                   
                   
                   
                   
                   
                 protease inhibitor 
               
               
                   
                   
                   
                   
                   
                 (antileukoproteinase) 
               
               
                 AQP3_HUMAN 
                 AQP3 
                 NM_004925 
                 234642 
                 −0.42891866 
                 Aquaporin 3 
               
               
                 SPIB_HUMAN 
                 SPIB 
                 NM_003121 
                 192861 
                 −0.41021146 
                 Spi-B transcription 
               
               
                   
                   
                   
                   
                   
                 factor (Spi-1/PU.1 
               
               
                   
                   
                   
                   
                   
                 related) 
               
               
                 P05209 
                 K-ALPHA-1 
                 NM_006082 
                 334842 
                 0.41796901 
                 Tubulin, alpha, 
               
               
                   
                   
                   
                   
                   
                 ubiquitous 
               
               
                 DRG1_HUMAN 
                 DRG1 
                 NM_004147 
                 115242 
                 0.41879372 
                 Developmentally 
               
               
                   
                   
                   
                   
                   
                 regulated GTP binding 
               
               
                   
                   
                   
                   
                   
                 protein 1 
               
               
                 PHMX_HUMAN 
                 PHEMX 
                 NM_005705 
                 271954 
                 0.38728757 
                 Pan-hematopoietic 
               
               
                   
                   
                   
                   
                   
                 expression 
               
               
                 P05209 
                 K-ALPHA-1 
                 NM_006082 
                 334842 
                 0.41741385 
                 Tubulin, alpha, 
               
               
                   
                   
                   
                   
                   
                 ubiquitous 
               
               
                 HSAC018335 
                 0 
                 AL137428 
                 306459 
                 −0.45404252 
                   Homo sapiens  mRNA; 
               
               
                   
                   
                   
                   
                   
                 cDNA 
               
               
                   
                   
                   
                   
                   
                 DKFZp761N1323 (from 
               
               
                   
                   
                   
                   
                   
                 clone 
               
               
                   
                   
                   
                   
                   
                 DKFZp761N1323) 
               
               
                 POSN_HUMAN 
                 OSF-2 
                 NM_006475 
                 136348 
                 0.42814786 
                 Osteoblast specific 
               
               
                   
                   
                   
                   
                   
                 factor 2 (fasciclin I-like) 
               
               
                 DHC3_HUMAN 
                 CBR3 
                 NM_001236 
                 154510 
                 −0.48089013 
                 Carbonyl reductase 3 
               
               
                 NCR2_HUMAN 
                 NCOR2 
                 NM_006312 
                 287994 
                 0.42024512 
                 Nuclear receptor co- 
               
               
                   
                   
                   
                   
                   
                 repressor 2 
               
               
                 HSAC015262 
                 0 
                 AK021531 
                 224398 
                 0.43632187 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ11469 fis, clone 
               
               
                   
                   
                   
                   
                   
                 HEMBA1001658 
               
               
                 Q14113 
                 AEBP1 
                 NM_001129 
                 118397 
                 0.42087649 
                 AE binding protein 1 
               
               
                 TBX2_HUMAN 
                 TBX2 
                 AK001031 
                 322856 
                 0.41381789 
                 T-box 2 
               
               
                 CRF_HUMAN 
                 CRH 
                 NM_000756 
                 75294 
                 −0.41353804 
                 Corticotropin releasing 
               
               
                   
                   
                   
                   
                   
                 hormone 
               
               
                 Q9NUJ7 
                 FLJ11323 
                 NM_018390 
                 25625 
                 −0.43842923 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ11323 
               
               
                 Q96DU1 
                 AKAP2 
                 AJ303079 
                 42322 
                 −0.44106809 
                 A kinase (PRKA) 
               
               
                   
                   
                   
                   
                   
                 anchor protein 2 
               
               
                 P05209 
                 K-ALPHA-1 
                 NM_006082 
                 334842 
                 0.40736744 
                 Tubulin, alpha, 
               
               
                   
                   
                   
                   
                   
                 ubiquitous 
               
               
                 Q969Y7 
                 MGC4677 
                 NM_052871 
                 337986 
                 0.39455354 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 MGC4677 
               
               
                 Q9BXY6 
                 FLJ13962 
                 NM_024862 
                 330407 
                 −0.44327759 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ13962 
               
               
                 K1CW_HUMAN 
                 HAIK1 
                 NM_015515 
                 9029 
                 −0.42594883 
                 Type I intermediate 
               
               
                   
                   
                   
                   
                   
                 filament cytokeratin 
               
               
                 HSAC019114 
                 FLJ22622 
                 NM_025151 
                 324841 
                 −0.4331912 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ22622 
               
               
                 PGS2_HUMAN 
                 DCN 
                 NM_001920 
                 76152 
                 0.39882715 
                 Decorin 
               
               
                 DCOP_HUMAN 
                 ODC-p 
                 NM_052998 
                 91681 
                 −0.41609162 
                 Ornithine 
               
               
                   
                   
                   
                   
                   
                 decarboxylase-like 
               
               
                   
                   
                   
                   
                   
                 protein 
               
               
                 HSAC020747 
                 0 
                 AK056828 
                 350748 
                 −0.40822563 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ32266 fis, clone 
               
               
                   
                   
                   
                   
                   
                 PROST1000419 
               
               
                 P05209 
                 K-ALPHA-1 
                 NM_006082 
                 334842 
                 0.39997295 
                 Tubulin, alpha, 
               
               
                   
                   
                   
                   
                   
                 ubiquitous 
               
               
                 Q96F00 
                 0 
                 AK025719 
                 251664 
                 0.39457176 
                   Homo sapiens  cDNA: 
               
               
                   
                   
                   
                   
                   
                 FLJ22066 fis, clone 
               
               
                   
                   
                   
                   
                   
                 HEP10611 
               
               
                 ISK5_HUMAN 
                 SPINK5 
                 NM_006846 
                 331555 
                 −0.43770884 
                 Serine protease 
               
               
                   
                   
                   
                   
                   
                 inhibitor, Kazal type, 5 
               
               
                 GFR1_HUMAN 
                 GFRA1 
                 NM_005264 
                 105445 
                 0.37859516 
                 GDNF family receptor 
               
               
                   
                   
                   
                   
                   
                 alpha 1 
               
               
                 AAF24516 
                 NUDEL 
                 NM_030808 
                 3850 
                 −0.40726277 
                 LIS1-interacting protein 
               
               
                   
                   
                   
                   
                   
                 NUDEL; 
               
               
                   
                   
                   
                   
                   
                 endooligopeptidase A 
               
               
                 P05209 
                 K-ALPHA-1 
                 NM_006082 
                 334842 
                 0.39594293 
                 Tubulin, alpha, 
               
               
                   
                   
                   
                   
                   
                 ubiquitous 
               
               
                 O60836 
                 T1A-2 
                 NM_013317 
                 135150 
                 0.37127534 
                 Lung type-I cell 
               
               
                   
                   
                   
                   
                   
                 membrane-associated 
               
               
                   
                   
                   
                   
                   
                 glycoprotein 
               
               
                 KLKA_HUMAN 
                 KLK10 
                 NM_002776 
                 69423 
                 −0.40584943 
                 Kallikrein 10 
               
               
                 Q96KC3 
                 MGC3047 
                 NM_032348 
                 59384 
                 0.39922401 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 MGC3047 
               
               
                 O95274 
                 C4.4A 
                 NM_014400 
                 11950 
                 −0.39942513 
                 GPI-anchored 
               
               
                   
                   
                   
                   
                   
                 metastasis-associated 
               
               
                   
                   
                   
                   
                   
                 protein homolog 
               
               
                 HSAC015726 
                 SERPINB13 
                 AJ001696 
                 241407 
                 −0.41273549 
                 Serine (or cysteine) 
               
               
                   
                   
                   
                   
                   
                 proteinase inhibitor, 
               
               
                   
                   
                   
                   
                   
                 clade B (ovalbumin), 
               
               
                   
                   
                   
                   
                   
                 member 13 
               
               
                 SEN7_HUMAN 
                 SENP7 
                 AL136599 
                 30443 
                 −0.37916215 
                 Sentrin/SUMO-specific 
               
               
                   
                   
                   
                   
                   
                 protease 
               
               
                 HSAC015968 
                 RPL34P2 
                 AL049714 
                 247903 
                 −0.39984188 
                 Ribosomal protein L34 
               
               
                   
                   
                   
                   
                   
                 pseudogene 2 
               
               
                 IM8B_HUMAN 
                 TIMM8B 
                 NM_012459 
                 279915 
                 −0.39646264 
                 Translocase of inner 
               
               
                   
                   
                   
                   
                   
                 mitochondrial 
               
               
                   
                   
                   
                   
                   
                 membrane 8 homolog 
               
               
                   
                   
                   
                   
                   
                 B (yeast) 
               
               
                 P05209 
                 K-ALPHA-1 
                 NM_006082 
                 334842 
                 0.39265415 
                 Tubulin, alpha, 
               
               
                   
                   
                   
                   
                   
                 ubiquitous 
               
               
                 CYTB_HUMAN 
                 CSTB 
                 NM_000100 
                 695 
                 −0.39593616 
                 Cystatin B (stefin B) 
               
               
                 MMDP_HUMAN 
                 MMD 
                 NM_012329 
                 79889 
                 0.35585533 
                 Monocyte to 
               
               
                   
                   
                   
                   
                   
                 macrophage 
               
               
                   
                   
                   
                   
                   
                 differentiation- 
               
               
                   
                   
                   
                   
                   
                 associated 
               
               
                 Q9H5J1 
                 PREI3 
                 NM_015387 
                 107942 
                 −0.39957843 
                 Preimplantation protein 3 
               
               
                 Q9Y283 
                 INVS 
                 NM_014425 
                 104715 
                 0.38165914 
                 Inversin 
               
               
                 S107_HUMAN 
                 S100A7 
                 NM_002963 
                 112408 
                 −0.38002947 
                 S100 calcium binding 
               
               
                   
                   
                   
                   
                   
                 protein A7 (psoriasin 1) 
               
               
                 SR19_HUMAN 
                 SRP19 
                 NM_003135 
                 2943 
                 −0.39927981 
                 Signal recognition 
               
               
                   
                   
                   
                   
                   
                 particle 19 kD 
               
               
                 MA17_HUMAN 
                 DD96 
                 NM_005764 
                 271473 
                 −0.38289729 
                 Epithelial protein up- 
               
               
                   
                   
                   
                   
                   
                 regulated in carcinoma, 
               
               
                   
                   
                   
                   
                   
                 membrane associated 
               
               
                   
                   
                   
                   
                   
                 protein 17 
               
               
                 O75943 
                 RAD17 
                 NM_002873 
                 16184 
                 −0.38971266 
                 RAD17 homolog ( S. pombe ) 
               
               
                 THA_HUMAN 
                 THRA 
                 NM_003250 
                 724 
                 0.38475204 
                 Thyroid hormone 
               
               
                   
                   
                   
                   
                   
                 receptor, alpha 
               
               
                   
                   
                   
                   
                   
                 (erythroblastic 
               
               
                   
                   
                   
                   
                   
                 leukemia viral (v-erb-a) 
               
               
                   
                   
                   
                   
                   
                 oncogene homolog, 
               
               
                   
                   
                   
                   
                   
                 avian) 
               
               
                 HSAC008967 
                 0 
                 AK021982 
                 287465 
                 0.38611307 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ11920 fis, clone 
               
               
                   
                   
                   
                   
                   
                 HEMBB1000312 
               
               
                 TFE2_HUMAN 
                 TCF3 
                 M31523 
                 101047 
                 0.38678059 
                 Transcription factor 3 
               
               
                   
                   
                   
                   
                   
                 (E2A immunoglobulin 
               
               
                   
                   
                   
                   
                   
                 enhancer binding 
               
               
                   
                   
                   
                   
                   
                 factors E12/E47) 
               
               
                 SUL2_HUMAN 
                 KIAA1247 
                 AB033073 
                 43857 
                 0.39182636 
                 Similar to glucosamine- 
               
               
                   
                   
                   
                   
                   
                 6-sulfatases 
               
               
                 HRA3_HUMAN 
                 HTRA3 
                 AY040094 
                 60440 
                 0.38043383 
                 Serine protease 
               
               
                   
                   
                   
                   
                   
                 HTRA3 
               
               
                 CN4A_HUMAN 
                 PDE4A 
                 NM_006202 
                 89901 
                 0.36750244 
                 Phosphodiesterase 4A, 
               
               
                   
                   
                   
                   
                   
                 cAMP-specific 
               
               
                   
                   
                   
                   
                   
                 (phosphodiesterase E2 
               
               
                   
                   
                   
                   
                   
                 dunce homolog, 
               
               
                   
                   
                   
                   
                   
                   Drosophila ) 
               
               
                 LTB2_HUMAN 
                 LTBP2 
                 NM_000428 
                 83337 
                 0.36424793 
                 Latent transforming 
               
               
                   
                   
                   
                   
                   
                 growth factor beta 
               
               
                   
                   
                   
                   
                   
                 binding protein 2 
               
               
                 CSF2_HUMAN 
                 CSF2 
                 NM_000758 
                 1349 
                 0.34759785 
                 Colony stimulating 
               
               
                   
                   
                   
                   
                   
                 factor 2 (granulocyte- 
               
               
                   
                   
                   
                   
                   
                 macrophage) 
               
               
                 S109_HUMAN 
                 S100A9 
                 NM_002965 
                 112405 
                 −0.38115533 
                 S100 calcium binding 
               
               
                   
                   
                   
                   
                   
                 protein A9 (calgranulin 
               
               
                   
                   
                   
                   
                   
                 B) 
               
               
                 MAL2_HUMAN 
                 MAL2 
                 NM_052886 
                 76550 
                 −0.37756452 
                 Mal, T-cell 
               
               
                   
                   
                   
                   
                   
                 differentiation protein 2 
               
               
                 HSAC004288 
                 LANO 
                 NM_018214 
                 35091 
                 −0.39020801 
                 LAP (leucine-rich 
               
               
                   
                   
                   
                   
                   
                 repeats and PDZ) and 
               
               
                   
                   
                   
                   
                   
                 no PDZ protein 
               
               
                 P05209 
                 K-ALPHA-1 
                 NM_006082 
                 334842 
                 0.37816007 
                 Tubulin, alpha, 
               
               
                   
                   
                   
                   
                   
                 ubiquitous 
               
               
                 EMP3_HUMAN 
                 EMP3 
                 NM_001425 
                 9999 
                 0.37961495 
                 Epithelial membrane 
               
               
                   
                   
                   
                   
                   
                 protein 3 
               
               
                 LUM_HUMAN 
                 LUM 
                 NM_002345 
                 79914 
                 0.36091717 
                 Lumican 
               
               
                 Q8NC43 
                 FLJ23091 
                 NM_024911 
                 250746 
                 0.4002659 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ23091 
               
               
                 HRA1_HUMAN 
                 PRSS11 
                 NM_002775 
                 75111 
                 0.38314991 
                 Protease, serine, 11 
               
               
                   
                   
                   
                   
                   
                 (IGF binding) 
               
               
                 CAH6_HUMAN 
                 CA6 
                 NM_001215 
                 100322 
                 0.38495881 
                 Carbonic anhydrase VI 
               
               
                 SCGF_HUMAN 
                 SCGF 
                 NM_002975 
                 105927 
                 0.38520465 
                 Stem cell growth factor; 
               
               
                   
                   
                   
                   
                   
                 lymphocyte secreted 
               
               
                   
                   
                   
                   
                   
                 C-type lectin 
               
               
                 CALD_HUMAN 
                 CALD1 
                 NM_033138 
                 325474 
                 0.36017333 
                 Caldesmon 1 
               
               
                 SYH_HUMAN 
                 HARS 
                 NM_002109 
                 77798 
                 0.34476889 
                 Histidyl-tRNA 
               
               
                   
                   
                   
                   
                   
                 synthetase 
               
               
                 Q8IXQ7 
                 LABH1 
                 NM_032604 
                 98608 
                 0.36012503 
                 Lung alpha/beta 
               
               
                   
                   
                   
                   
                   
                 hydrolase 1 
               
               
                 WEE1_HUMAN 
                 WEE1 
                 X62048 
                 75188 
                 −0.38967133 
                 WEE1+ homolog ( S. pombe ) 
               
               
                 Q9H0B8 
                 DKFZP434B044 
                 NM_031476 
                 262958 
                 0.36902739 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 DKFZp434B044 
               
               
                 M1B1_HUMAN 
                 MAN1B1 
                 NM_016219 
                 279881 
                 0.37430439 
                 Mannosidase, alpha, 
               
               
                   
                   
                   
                   
                   
                 class 1B, member 1 
               
               
                 FBX8_HUMAN 
                 FBXO8 
                 NM_012180 
                 76917 
                 −0.37436238 
                 F-box only protein 8 
               
               
                 SM3C_HUMAN 
                 SEMA3C 
                 NM_006379 
                 171921 
                 0.35697551 
                 Sema domain, 
               
               
                   
                   
                   
                   
                   
                 immunoglobulin 
               
               
                   
                   
                   
                   
                   
                 domain (Ig), short basic 
               
               
                   
                   
                   
                   
                   
                 domain, secreted, 
               
               
                   
                   
                   
                   
                   
                 (semaphorin) 3C 
               
               
                 RB25_HUMAN 
                 CATX-8 
                 NM_020387 
                 150826 
                 −0.38816294 
                 CATX-8 protein 
               
               
                 ROL_HUMAN 
                 HNRPL 
                 NM_001533 
                 2730 
                 0.34146766 
                 Heterogeneous nuclear 
               
               
                   
                   
                   
                   
                   
                 ribonucleoprotein L 
               
               
                 FX37_HUMAN 
                 MGC11279 
                 NM_024326 
                 10915 
                 −0.38119046 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 MGC11279 
               
               
                 HSAC003262 
                 KIAA0350 
                 AB002348 
                 23263 
                 −0.39564135 
                 KIAA0350 protein 
               
               
                 P05209 
                 K-ALPHA-1 
                 NM_006082 
                 334842 
                 0.37391308 
                 Tubulin, alpha, 
               
               
                   
                   
                   
                   
                   
                 ubiquitous 
               
               
                 BTE4_HUMAN 
                 KLF16 
                 NM_031918 
                 303194 
                 0.40092333 
                 Kruppel-like factor 16 
               
               
                 MK_HUMAN 
                 MDK 
                 NM_002391 
                 82045 
                 −0.38900237 
                 Midkine (neurite 
               
               
                   
                   
                   
                   
                   
                 growth-promoting 
               
               
                   
                   
                   
                   
                   
                 factor 2) 
               
               
                 Q9NRD9 
                 DUOX1 
                 NM_017434 
                 272813 
                 −0.3913498 
                 Dual oxidase 1 
               
               
                 P05209 
                 K-ALPHA-1 
                 NM_006082 
                 334842 
                 0.36936704 
                 Tubulin, alpha, 
               
               
                   
                   
                   
                   
                   
                 ubiquitous 
               
               
                 Z185_HUMAN 
                 ZNF185 
                 NM_007150 
                 16622 
                 −0.36378851 
                 Zinc finger protein 185 
               
               
                   
                   
                   
                   
                   
                 (LIM domain) 
               
               
                 TBG2_HUMAN 
                 TUBG2 
                 NM_016437 
                 279669 
                 0.34203519 
                 Tubulin, gamma 2 
               
               
                 AAKC_HUMAN 
                 PRKAB2 
                 NM_005399 
                 50732 
                 −0.35738949 
                 Protein kinase, AMP- 
               
               
                   
                   
                   
                   
                   
                 activated, beta 2 non- 
               
               
                   
                   
                   
                   
                   
                 catalytic subunit 
               
               
                 HSAC006508 
                 COL18A1 
                 AF018081 
                 78409 
                 0.37705859 
                 Collagen, type XVIII, 
               
               
                   
                   
                   
                   
                   
                 alpha 1 
               
               
                 Q9BSY6 
                 ZD52F10 
                 NM_033317 
                 32343 
                 −0.37419257 
                 Hypothetical gene 
               
               
                   
                   
                   
                   
                   
                 ZD52F10 
               
               
                 SOX4_HUMAN 
                 0 
                 AJ420500 
                 351928 
                 −0.41521785 
                   Homo sapiens  mRNA 
               
               
                   
                   
                   
                   
                   
                 full length insert cDNA 
               
               
                   
                   
                   
                   
                   
                 clone EUROIMAGE 
               
               
                   
                   
                   
                   
                   
                 1977059 
               
               
                 P05209 
                 K-ALPHA-1 
                 NM_006082 
                 334842 
                 0.37198391 
                 Tubulin, alpha, 
               
               
                   
                   
                   
                   
                   
                 ubiquitous 
               
               
                 MIC2_HUMAN 
                 MIC2 
                 NM_002414 
                 177543 
                 0.36316608 
                 Antigen identified by 
               
               
                   
                   
                   
                   
                   
                 monoclonal antibodies 
               
               
                   
                   
                   
                   
                   
                 12E7, F21 and O13 
               
               
                 VWF_HUMAN 
                 VWF 
                 NM_000552 
                 110802 
                 −0.36187757 
                 Von Willebrand factor 
               
               
                 MFA5_HUMAN 
                 MAGP2 
                 NM_003480 
                 300946 
                 0.34145531 
                 Microfibril-associated 
               
               
                   
                   
                   
                   
                   
                 glycoprotein-2 
               
               
                 ELAF_HUMAN 
                 PI3 
                 NM_002638 
                 112341 
                 −0.39367703 
                 Protease inhibitor 3, 
               
               
                   
                   
                   
                   
                   
                 skin-derived (SKALP) 
               
               
                 WD13_HUMAN 
                 WDR13 
                 NM_017883 
                 12142 
                 0.35576479 
                 WD repeat domain 13 
               
               
                 PCB1_HUMAN 
                 PCBP1 
                 NM_006196 
                 2853 
                 −0.35199657 
                 Poly(rC) binding 
               
               
                   
                   
                   
                   
                   
                 protein 1 
               
               
                 DYHC_HUMAN 
                 DNCH1 
                 AB002323 
                 7720 
                 0.36908919 
                 Dynein, cytoplasmic, 
               
               
                   
                   
                   
                   
                   
                 heavy polypeptide 1 
               
               
                 Q8WUB2 
                 HSU79274 
                 NM_013300 
                 150555 
                 −0.41095099 
                 Protein predicted by 
               
               
                   
                   
                   
                   
                   
                 clone 23733 
               
               
                 Q96N74 
                 PGLYRP 
                 NM_052890 
                 282244 
                 −0.37818832 
                 Peptidoglycan 
               
               
                   
                   
                   
                   
                   
                 recognition protein L 
               
               
                   
                   
                   
                   
                   
                 precursor 
               
               
                 HSAC018816 
                 0 
                 AK055723 
                 310919 
                 −0.37825237 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ31161 fis, clone 
               
               
                   
                   
                   
                   
                   
                 KIDNE1000028 
               
               
                 PPL2_HUMAN 
                 PPIL2 
                 NM_014337 
                 93523 
                 −0.34926253 
                 Peptidylprolyl 
               
               
                   
                   
                   
                   
                   
                 isomerase 
               
               
                   
                   
                   
                   
                   
                 (cyclophilin)-like 2 
               
               
                 HSAC015090 
                 0 
                 AK055294 
                 211132 
                 0.34738745 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ30732 fis, clone 
               
               
                   
                   
                   
                   
                   
                 FEBRA2000126, 
               
               
                   
                   
                   
                   
                   
                 weakly similar to  Mus   
               
               
                   
                   
                   
                   
                   
                   musculus  PDZ domain 
               
               
                   
                   
                   
                   
                   
                 actin 
               
               
                 P05209 
                 K-ALPHA-1 
                 NM_006082 
                 334842 
                 0.36404497 
                 Tubulin, alpha, 
               
               
                   
                   
                   
                   
                   
                 ubiquitous 
               
               
                 DSG3_HUMAN 
                 DSG3 
                 NM_001944 
                 1925 
                 −0.35916779 
                 Desmoglein 3 
               
               
                   
                   
                   
                   
                   
                 (pemphigus vulgaris 
               
               
                   
                   
                   
                   
                   
                 antigen) 
               
               
                 CTGF_HUMAN 
                 CTGF 
                 NM_001901 
                 75511 
                 0.36449331 
                 Connective tissue 
               
               
                   
                   
                   
                   
                   
                 growth factor 
               
               
                 Q96BW1 
                 0 
                 AK056354 
                 91612 
                 0.34964326 
                 Homo sapiens, clone 
               
               
                   
                   
                   
                   
                   
                 MGC: 23937 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 3930177, 
               
               
                   
                   
                   
                   
                   
                 mRNA, complete cds 
               
               
                 P05209 
                 K-ALPHA-1 
                 NM_006082 
                 334842 
                 0.36440521 
                 Tubulin, alpha, 
               
               
                   
                   
                   
                   
                   
                 ubiquitous 
               
               
                 HSAC020349 
                 0 
                 BC014584 
                 348710 
                 0.33020586 
                 Homo sapiens, clone 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 4047062, 
               
               
                   
                   
                   
                   
                   
                 mRNA 
               
               
                 G3P2_HUMAN 
                 GAPD 
                 NM_002046 
                 169476 
                 0.36112372 
                 Glyceraldehyde-3- 
               
               
                   
                   
                   
                   
                   
                 phosphate 
               
               
                   
                   
                   
                   
                   
                 dehydrogenase 
               
               
                 DES1_HUMAN 
                 DESC1 
                 NM_014058 
                 201877 
                 −0.37199135 
                 DESC1 protein 
               
               
                 PAI2_HUMAN 
                 SERPINB2 
                 NM_002575 
                 75716 
                 −0.39418824 
                 Serine (or cysteine) 
               
               
                   
                   
                   
                   
                   
                 proteinase inhibitor, 
               
               
                   
                   
                   
                   
                   
                 clade B (ovalbumin), 
               
               
                   
                   
                   
                   
                   
                 member 2 
               
               
                 PYG2_HUMAN 
                 0 
                 BC006132 
                 172084 
                 0.36848424 
                 Homo sapiens, clone 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 3627860, 
               
               
                   
                   
                   
                   
                   
                 mRNA, partial cds 
               
               
                 CA17_HUMAN 
                 COL7A1 
                 NM_000094 
                 1640 
                 0.35840992 
                 Collagen, type VII, 
               
               
                   
                   
                   
                   
                   
                 alpha 1 (epidermolysis 
               
               
                   
                   
                   
                   
                   
                 bullosa, dystrophic, 
               
               
                   
                   
                   
                   
                   
                 dominant and 
               
               
                   
                   
                   
                   
                   
                 recessive) 
               
               
                 Q8NG54 
                 FLJ21212 
                 NM_024642 
                 47099 
                 −0.35274616 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ21212 
               
               
                 Q9H6K5 
                 FLJ22184 
                 NM_025094 
                 288540 
                 −0.36166463 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ22184 
               
               
                 Q96FP4 
                 0 
                 BC010607 
                 104679 
                 0.34999129 
                 Homo sapiens, clone 
               
               
                   
                   
                   
                   
                   
                 MGC: 18216 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 4156235, 
               
               
                   
                   
                   
                   
                   
                 mRNA, complete cds 
               
               
                 HSAC019418 
                 0 
                 AK021970 
                 333438 
                 −0.37893723 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ11908 fis, clone 
               
               
                   
                   
                   
                   
                   
                 HEMBB1000089 
               
               
                 HSAC019917 
                 0 
                 AF130069 
                 343363 
                 −0.34377216 
                   Homo sapiens  clone 
               
               
                   
                   
                   
                   
                   
                 FLB8436 PRO2277 
               
               
                   
                   
                   
                   
                   
                 mRNA, complete cds 
               
               
                 HSAC003296 
                 TACSTD2 
                 NM_002353 
                 23582 
                 −0.3427956 
                 Tumor-associated 
               
               
                   
                   
                   
                   
                   
                 calcium signal 
               
               
                   
                   
                   
                   
                   
                 transducer 2 
               
               
                 TTC7_HUMAN 
                 KIAA1140 
                 AB032966 
                 131728 
                 0.34916061 
                 KIAA1140 protein 
               
               
                 G3P2_HUMAN 
                 GAPD 
                 NM_002046 
                 169476 
                 0.35497237 
                 Glyceraldehyde-3- 
               
               
                   
                   
                   
                   
                   
                 phosphate 
               
               
                   
                   
                   
                   
                   
                 dehydrogenase 
               
               
                 Q86VR7 
                 0 
                 BC016993 
                 293236 
                 −0.40258581 
                 Homo sapiens, clone 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 4401841, 
               
               
                   
                   
                   
                   
                   
                 mRNA 
               
               
                 G3P2_HUMAN 
                 GAPD 
                 NM_002046 
                 169476 
                 0.35582864 
                 Glyceraldehyde-3- 
               
               
                   
                   
                   
                   
                   
                 phosphate 
               
               
                   
                   
                   
                   
                   
                 dehydrogenase 
               
               
                 Q96CG8 
                 0 
                 BC014245 
                 283713 
                 0.34868937 
                 Homo sapiens, Similar 
               
               
                   
                   
                   
                   
                   
                 to RIKEN cDNA 
               
               
                   
                   
                   
                   
                   
                 1110014B07 gene, 
               
               
                   
                   
                   
                   
                   
                 clone MGC: 20766 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 4586039, 
               
               
                   
                   
                   
                   
                   
                 mRNA, complete c 
               
               
                 HSAC004760 
                 0 
                 S73288 
                 46320 
                 −0.36573481 
                 Small proline-rich 
               
               
                   
                   
                   
                   
                   
                 protein SPRK [human, 
               
               
                   
                   
                   
                   
                   
                 odontogenic 
               
               
                   
                   
                   
                   
                   
                 keratocysts, mRNA 
               
               
                   
                   
                   
                   
                   
                 Partial, 317 nt] 
               
               
                 KLK5_HUMAN 
                 KLK5 
                 NM_012427 
                 50915 
                 −0.36794706 
                 Kallikrein 5 
               
               
                 SREC_HUMAN 
                 SREC 
                 NM_003693 
                 57735 
                 0.35910977 
                 Acetyl LDL receptor; 
               
               
                   
                   
                   
                   
                   
                 SREC 
               
               
                 Q8IVC7 
                 EPSTI1 
                 NM_033255 
                 343800 
                 −0.35253232 
                 Epithelial stromal 
               
               
                   
                   
                   
                   
                   
                 interaction 1 (breast) 
               
               
                 HSAC008195 
                 0 
                 AF339799 
                 174045 
                 −0.36573039 
                   Homo sapiens  clone 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 2363394, 
               
               
                   
                   
                   
                   
                   
                 mRNA sequence 
               
               
                 TPM2_HUMAN 
                 TPM1 
                 NM_000366 
                 77899 
                 0.3486721 
                 Tropomyosin 1 (alpha) 
               
               
                 Q9UFS8 
                 AGS3 
                 AL117478 
                 239370 
                 −0.35552159 
                 Likely ortholog of rat 
               
               
                   
                   
                   
                   
                   
                 activator of G-protein 
               
               
                   
                   
                   
                   
                   
                 signaling 3 
               
               
                 G3P2_HUMAN 
                 GAPD 
                 NM_002046 
                 169476 
                 0.35209827 
                 Glyceraldehyde-3- 
               
               
                   
                   
                   
                   
                   
                 phosphate 
               
               
                   
                   
                   
                   
                   
                 dehydrogenase 
               
               
                 HSAC011719 
                 CLDN5 
                 NM_003277 
                 110903 
                 −0.35850977 
                 Claudin 5 
               
               
                   
                   
                   
                   
                   
                 (transmembrane 
               
               
                   
                   
                   
                   
                   
                 protein deleted in 
               
               
                   
                   
                   
                   
                   
                 velocardiofacial 
               
               
                   
                   
                   
                   
                   
                 syndrome) 
               
               
                 G3P2_HUMAN 
                 GAPD 
                 NM_002046 
                 169476 
                 0.34936984 
                 Glyceraldehyde-3- 
               
               
                   
                   
                   
                   
                   
                 phosphate 
               
               
                   
                   
                   
                   
                   
                 dehydrogenase 
               
               
                 HSAC002456 
                 0 
                 AK055225 
                 15167 
                 −0.34350313 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ30663 fis, clone 
               
               
                   
                   
                   
                   
                   
                 FCBBF1000598, 
               
               
                   
                   
                   
                   
                   
                 moderately similar to 
               
               
                   
                   
                   
                   
                   
                 ZINC FINGER 
               
               
                   
                   
                   
                   
                   
                 PROTEIN 84 
               
               
                 P05209 
                 K-ALPHA-1 
                 NM_006082 
                 334842 
                 0.35175871 
                 Tubulin, alpha, 
               
               
                   
                   
                   
                   
                   
                 ubiquitous 
               
               
                 HSAC014332 
                 BENE 
                 U17077 
                 185055 
                 −0.36524246 
                 BENE protein 
               
               
                 G3P2_HUMAN 
                 GAPD 
                 NM_002046 
                 169476 
                 0.34976822 
                 Glyceraldehyde-3- 
               
               
                   
                   
                   
                   
                   
                 phosphate 
               
               
                   
                   
                   
                   
                   
                 dehydrogenase 
               
               
                 HSAC020817 
                 0 
                 AK055932 
                 350820 
                 −0.36618612 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ31370 fis, clone 
               
               
                   
                   
                   
                   
                   
                 NB9N42000122 
               
               
                 KLKB_HUMAN 
                 KLK11 
                 NM_006853 
                 57771 
                 −0.34648295 
                 Kallikrein 11 
               
               
                 AAC1_HUMAN 
                 ACTN1 
                 NM_001102 
                 119000 
                 0.33964129 
                 Actinin, alpha 1 
               
               
                 G3P2_HUMAN 
                 GAPD 
                 NM_002046 
                 169476 
                 0.3514833 
                 Glyceraldehyde-3- 
               
               
                   
                   
                   
                   
                   
                 phosphate 
               
               
                   
                   
                   
                   
                   
                 dehydrogenase 
               
               
                 Q8WW05 
                 0 
                 AC006017 
                 131311 
                 −0.34898752 
                   Homo sapiens  PAC 
               
               
                   
                   
                   
                   
                   
                 clone RP5-981O7 from 
               
               
                   
                   
                   
                   
                   
                 7q34-q36 
               
               
                 HAS3_HUMAN 
                 HAS3 
                 AF232772 
                 85962 
                 −0.37055655 
                 Hyaluronan synthase 3 
               
               
                 HSAC019767 
                 0 
                 AK022838 
                 336419 
                 −0.35771887 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ12776 fis, clone 
               
               
                   
                   
                   
                   
                   
                 NT2RP2001678 
               
               
                 O60565 
                 CKTSF1B1 
                 NM_013372 
                 40098 
                 0.33592448 
                 Cysteine knot 
               
               
                   
                   
                   
                   
                   
                 superfamily 1, BMP 
               
               
                   
                   
                   
                   
                   
                 antagonist 1 
               
               
                 HSAC013123 
                 DKFZp547D065 
                 AL390147 
                 134742 
                 0.35377439 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 DKFZp547D065 
               
               
                 G3P2_HUMAN 
                 GAPD 
                 NM_002046 
                 169476 
                 0.35115594 
                 Glyceraldehyde-3- 
               
               
                   
                   
                   
                   
                   
                 phosphate 
               
               
                   
                   
                   
                   
                   
                 dehydrogenase 
               
               
                 Q14707 
                 KTN1 
                 NM_004986 
                 211577 
                 0.34546179 
                 Kinectin 1 (kinesin 
               
               
                   
                   
                   
                   
                   
                 receptor) 
               
               
                 HSAC001617 
                 UCRP 
                 AF388367 
                 8201 
                 −0.32315934 
                 Usher critical region 
               
               
                   
                   
                   
                   
                   
                 protein pseudogene 
               
               
                 HSAC017169 
                 0 
                 AL137617 
                 274583 
                 −0.36507656 
                   Homo sapiens  mRNA; 
               
               
                   
                   
                   
                   
                   
                 cDNA 
               
               
                   
                   
                   
                   
                   
                 DKFZp434C0512 (from 
               
               
                   
                   
                   
                   
                   
                 clone 
               
               
                   
                   
                   
                   
                   
                 DKFZp434C0512) 
               
               
                 Q9H7K0 
                 0 
                 AK024480 
                 13766 
                 −0.35542828 
                   Homo sapiens  mRNA 
               
               
                   
                   
                   
                   
                   
                 for FLJ00074 protein, 
               
               
                   
                   
                   
                   
                   
                 partial cds 
               
               
                 G3P2_HUMAN 
                 GAPD 
                 NM_002046 
                 169476 
                 0.34999375 
                 Glyceraldehyde-3- 
               
               
                   
                   
                   
                   
                   
                 phosphate 
               
               
                   
                   
                   
                   
                   
                 dehydrogenase 
               
               
                 HSAC015798 
                 0 
                 AK000745 
                 243901 
                 0.33333793 
                   Homo sapiens  mRNA; 
               
               
                   
                   
                   
                   
                   
                 cDNA 
               
               
                   
                   
                   
                   
                   
                 DKFZp564C1563 (from 
               
               
                   
                   
                   
                   
                   
                 clone 
               
               
                   
                   
                   
                   
                   
                 DKFZp564C1563) 
               
               
                 CLH1_HUMAN 
                 CLTC 
                 NM_004859 
                 178710 
                 0.33305718 
                 Clathrin, heavy 
               
               
                   
                   
                   
                   
                   
                 polypeptide (Hc) 
               
               
                 PAI1_HUMAN 
                 SERPINE1 
                 NM_000602 
                 82085 
                 0.32335137 
                 Serine (or cysteine) 
               
               
                   
                   
                   
                   
                   
                 proteinase inhibitor, 
               
               
                   
                   
                   
                   
                   
                 clade E (nexin, 
               
               
                   
                   
                   
                   
                   
                 plasminogen activator 
               
               
                   
                   
                   
                   
                   
                 inhibitor type 1), 
               
               
                 HSAC018152 
                 0 
                 AK057719 
                 303105 
                 −0.33343853 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ33157 fis, clone 
               
               
                   
                   
                   
                   
                   
                 UTERU2000393 
               
               
                 HSAC019360 
                 0 
                 AK024104 
                 333154 
                 −0.33563282 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ14042 fis, clone 
               
               
                   
                   
                   
                   
                   
                 HEMBA1006038, 
               
               
                   
                   
                   
                   
                   
                 weakly similar to 
               
               
                   
                   
                   
                   
                   
                 LAMININ ALPHA-5 
               
               
                   
                   
                   
                   
                   
                 CHAIN 
               
               
                 Q9H7E9 
                 FLJ20989 
                 NM_023080 
                 169615 
                 0.33185124 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ20989 
               
               
                 TGF1_HUMAN 
                 TGFB1 
                 NM_000660 
                 1103 
                 0.36859438 
                 Transforming growth 
               
               
                   
                   
                   
                   
                   
                 factor, beta 1 
               
               
                 Q9NRA1 
                 PDGFC 
                 NM_016205 
                 43080 
                 0.33440168 
                 Platelet derived growth 
               
               
                   
                   
                   
                   
                   
                 factor C 
               
               
                 HSAC020279 
                 0 
                 BC014381 
                 348523 
                 −0.38018709 
                 Homo sapiens, clone 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 4046329, 
               
               
                   
                   
                   
                   
                   
                 mRNA 
               
               
                 Q8IXK0 
                 EDR2 
                 NM_004427 
                 165263 
                 0.3333879 
                 Early development 
               
               
                   
                   
                   
                   
                   
                 regulator 2 
               
               
                   
                   
                   
                   
                   
                 (polyhomeotic 2 
               
               
                   
                   
                   
                   
                   
                 homolog) 
               
               
                 HSAC017377 
                 PRO0514 
                 NM_014131 
                 278939 
                 −0.32206704 
                 PRO0514 protein 
               
               
                 Q9BPY8 
                 SMAP31 
                 NM_032495 
                 13775 
                 −0.39460445 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 SMAP31 
               
               
                 MT70_HUMAN 
                 M6A 
                 NM_019852 
                 268149 
                 0.35349822 
                 Putative 
               
               
                   
                   
                   
                   
                   
                 methyltransferase 
               
               
                 UDP2_HUMAN 
                 UGP2 
                 NM_006759 
                 77837 
                 0.32421497 
                 UDP-glucose 
               
               
                   
                   
                   
                   
                   
                 pyrophosphorylase 2 
               
               
                 O00205 
                 SULT2B1 
                 NM_004605 
                 94581 
                 −0.36104276 
                 Sulfotransferase family, 
               
               
                   
                   
                   
                   
                   
                 cytosolic, 2B, member 1 
               
               
                 Q96A75 
                 PGS1 
                 NM_024419 
                 278682 
                 0.33507703 
                 Phosphatidylglycerophosphate 
               
               
                   
                   
                   
                   
                   
                 Synthase 
               
               
                 PI4K_HUMAN 
                 PIK4CA 
                 NM_058004 
                 334874 
                 0.32401638 
                 Phosphatidylinositol 4- 
               
               
                   
                   
                   
                   
                   
                 kinase, catalytic, alpha 
               
               
                   
                   
                   
                   
                   
                 polypeptide 
               
               
                 SPT1_HUMAN 
                 SPINT1 
                 NM_003710 
                 233950 
                 −0.34424419 
                 Serine protease 
               
               
                   
                   
                   
                   
                   
                 inhibitor, Kunitz type 1 
               
               
                 TGM1_HUMAN 
                 TGM1 
                 NM_000359 
                 22 
                 −0.36535457 
                 Transglutaminase 1 (K 
               
               
                   
                   
                   
                   
                   
                 polypeptide epidermal 
               
               
                   
                   
                   
                   
                   
                 type I, protein- 
               
               
                   
                   
                   
                   
                   
                 glutamine-gamma- 
               
               
                   
                   
                   
                   
                   
                 glutamyltransferase) 
               
               
                 FPGT_HUMAN 
                 FPGT 
                 NM_003838 
                 150926 
                 −0.334427 
                 Fucose-1-phosphate 
               
               
                   
                   
                   
                   
                   
                 guanylyltransferase 
               
               
                 Q9H3D4 
                 TP63 
                 Y16961 
                 137569 
                 −0.33233956 
                 Tumor protein 63 kDa 
               
               
                   
                   
                   
                   
                   
                 with strong homology 
               
               
                   
                   
                   
                   
                   
                 to p53 
               
               
                 G3P2_HUMAN 
                 GAPD 
                 NM_002046 
                 169476 
                 0.3376594 
                 Glyceraldehyde-3- 
               
               
                   
                   
                   
                   
                   
                 phosphate 
               
               
                   
                   
                   
                   
                   
                 dehydrogenase 
               
               
                 TENA_HUMAN 
                 HXB 
                 NM_002160 
                 289114 
                 0.31189127 
                 Hexabrachion 
               
               
                   
                   
                   
                   
                   
                 (tenascin C, cytotactin) 
               
               
                 OAS1_HUMAN 
                 OAS1 
                 NM_016816 
                 82396 
                 −0.34392735 
                 2′,5′-oligoadenylate 
               
               
                   
                   
                   
                   
                   
                 synthetase 1 (40-46 kD) 
               
               
                 Q969E4 
                 MGC15737 
                 NM_032926 
                 39122 
                 0.34380675 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 MGC15737 
               
               
                 G3P2_HUMAN 
                 GAPD 
                 NM_002046 
                 169476 
                 0.33818775 
                 Glyceraldehyde-3- 
               
               
                   
                   
                   
                   
                   
                 phosphate 
               
               
                   
                   
                   
                   
                   
                 dehydrogenase 
               
               
                 IL6_HUMAN 
                 IL6 
                 NM_000600 
                 93913 
                 0.30335363 
                 Interleukin 6 
               
               
                   
                   
                   
                   
                   
                 (interferon, beta 2) 
               
               
                 LMB3_HUMAN 
                 LAMB3 
                 NM_000228 
                 75517 
                 0.32051769 
                 Laminin, beta 3 (nicein 
               
               
                   
                   
                   
                   
                   
                 (125 kD), kalinin 
               
               
                   
                   
                   
                   
                   
                 (140 kD), BM600 
               
               
                   
                   
                   
                   
                   
                 (125 kD)) 
               
               
                 HSAC015555 
                 DKFZp761K1423 
                 NM_018422 
                 236438 
                 −0.33416824 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 DKFZp761K1423 
               
               
                 BASP_HUMAN 
                 BASP1 
                 NM_006317 
                 79516 
                 0.3230565 
                 Brain abundant, 
               
               
                   
                   
                   
                   
                   
                 membrane attached 
               
               
                   
                   
                   
                   
                   
                 signal protein 1 
               
               
                 Q8NG12 
                 FLJ22792 
                 NM_024921 
                 267038 
                 −0.36618724 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ22792 
               
               
                 Q99603 
                 TRG@ 
                 AK056843 
                 112259 
                 −0.36306016 
                 T cell receptor gamma 
               
               
                   
                   
                   
                   
                   
                 locus 
               
               
                 TDE2_HUMAN 
                 KIAA1253 
                 AB033079 
                 146668 
                 0.32859657 
                 KIAA1253 protein 
               
               
                 ALC1_HUMAN 
                 IGHM 
                 X58529 
                 293441 
                 0.30789147 
                 Immunoglobulin heavy 
               
               
                   
                   
                   
                   
                   
                 constant mu 
               
               
                 G3P2_HUMAN 
                 GAPD 
                 NM_002046 
                 169476 
                 0.338632 
                 Glyceraldehyde-3- 
               
               
                   
                   
                   
                   
                   
                 phosphate 
               
               
                   
                   
                   
                   
                   
                 dehydrogenase 
               
               
                 KCC1_HUMAN 
                 CAMK1 
                 NM_003656 
                 184402 
                 0.32331521 
                 Calcium/calmodulin- 
               
               
                   
                   
                   
                   
                   
                 dependent protein 
               
               
                   
                   
                   
                   
                   
                 kinase I 
               
               
                 Q8NCP6 
                 GLE1L 
                 NM_001499 
                 169363 
                 0.33812915 
                 GLE1 RNA export 
               
               
                   
                   
                   
                   
                   
                 mediator-like (yeast) 
               
               
                 COM5_HUMAN 
                 HT002 
                 AK023070 
                 238928 
                 0.31500738 
                 HT002 protein; 
               
               
                   
                   
                   
                   
                   
                 hypertension-related 
               
               
                   
                   
                   
                   
                   
                 calcium-regulated gene 
               
               
                 HSAC001787 
                 SPC18 
                 NM_014300 
                 9534 
                 0.32516848 
                 Signal peptidase 
               
               
                   
                   
                   
                   
                   
                 complex (18 kD) 
               
               
                 HSAC020210 
                 0 
                 BC012014 
                 348340 
                 0.32291489 
                 Homo sapiens, clone 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 4509827, 
               
               
                   
                   
                   
                   
                   
                 mRNA, partial cds 
               
               
                 Q96AL8 
                 0 
                 BC016969 
                 7155 
                 −0.36007634 
                 Homo sapiens, clone 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 4428577, 
               
               
                   
                   
                   
                   
                   
                 mRNA, partial cds 
               
               
                 PEDF_HUMAN 
                 SERPINF1 
                 NM_002615 
                 173594 
                 0.3214249 
                 Serine (or cysteine) 
               
               
                   
                   
                   
                   
                   
                 proteinase inhibitor, 
               
               
                   
                   
                   
                   
                   
                 clade F (alpha-2 
               
               
                   
                   
                   
                   
                   
                 antiplasmin, pigment 
               
               
                   
                   
                   
                   
                   
                 epithelium derived 
               
               
                 GA15_HUMAN 
                 DDIT3 
                 NM_004083 
                 337761 
                 0.30554219 
                 DNA-damage-inducible 
               
               
                   
                   
                   
                   
                   
                 transcript 3 
               
               
                 NGAL_HUMAN 
                 LCN2 
                 NM_005564 
                 204238 
                 −0.34145982 
                 Lipocalin 2 (oncogene 
               
               
                   
                   
                   
                   
                   
                 24p3) 
               
               
                 RHOC_HUMAN 
                 ARHC 
                 NM_005167 
                 179735 
                 0.35111593 
                 Ras homolog gene 
               
               
                   
                   
                   
                   
                   
                 family, member C 
               
               
                 G3P2_HUMAN 
                 GAPD 
                 NM_002046 
                 169476 
                 0.33567842 
                 Glyceraldehyde-3- 
               
               
                   
                   
                   
                   
                   
                 phosphate 
               
               
                   
                   
                   
                   
                   
                 dehydrogenase 
               
               
                 O95491 
                 DNAH11 
                 NM_003777 
                 349084 
                 −0.37201261 
                 Dynein, axonemal, 
               
               
                   
                   
                   
                   
                   
                 heavy polypeptide 11 
               
               
                 NIF3_HUMAN 
                 NLI-IF 
                 NM_021198 
                 283724 
                 0.341321 
                 Nuclear LIM interactor- 
               
               
                   
                   
                   
                   
                   
                 interacting factor 
               
               
                 Q96MC2 
                 0 
                 AK057222 
                 123428 
                 −0.36359079 
                 Homo sapiens, Similar 
               
               
                   
                   
                   
                   
                   
                 to CG10958 gene 
               
               
                   
                   
                   
                   
                   
                 product, clone 
               
               
                   
                   
                   
                   
                   
                 MGC: 16372 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 3929220, 
               
               
                   
                   
                   
                   
                   
                 mRNA, complete cds 
               
               
                 KVB1_HUMAN 
                 KCNAB1 
                 AK057059 
                 172471 
                 −0.32465311 
                 Potassium voltage- 
               
               
                   
                   
                   
                   
                   
                 gated channel, shaker- 
               
               
                   
                   
                   
                   
                   
                 related subfamily, beta 
               
               
                   
                   
                   
                   
                   
                 member 1 
               
               
                 P20172 
                 AP2M1 
                 NM_004068 
                 152936 
                 0.33712949 
                 Adaptor-related protein 
               
               
                   
                   
                   
                   
                   
                 complex 2, mu 1 
               
               
                   
                   
                   
                   
                   
                 subunit 
               
               
                 CDX1_HUMAN 
                 CDX1 
                 NM_001804 
                 1545 
                 0.32711759 
                 Caudal type homeo 
               
               
                   
                   
                   
                   
                   
                 box transcription factor 1 
               
               
                 G3P2_HUMAN 
                 GAPD 
                 NM_002046 
                 169476 
                 0.32910404 
                 Glyceraldehyde-3- 
               
               
                   
                   
                   
                   
                   
                 phosphate 
               
               
                   
                   
                   
                   
                   
                 dehydrogenase 
               
               
                 LCFD_HUMAN 
                 FACL4 
                 NM_022977 
                 81452 
                 −0.33567272 
                 Fatty-acid-Coenzyme A 
               
               
                   
                   
                   
                   
                   
                 ligase, long-chain 4 
               
               
                 Q9NX63 
                 FLJ20420 
                 NM_017812 
                 6693 
                 −0.34188068 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ20420 
               
               
                 IBP7_HUMAN 
                 IGFBP7 
                 NM_001553 
                 119206 
                 0.32895548 
                 Insulin-like growth 
               
               
                   
                   
                   
                   
                   
                 factor binding protein 7 
               
               
                 HSAC018498 
                 0 
                 AK024867 
                 306710 
                 −0.35579721 
                   Homo sapiens  cDNA: 
               
               
                   
                   
                   
                   
                   
                 FLJ21214 fis, clone 
               
               
                   
                   
                   
                   
                   
                 COL00523 
               
               
                 HSAC009099 
                 0 
                 AK024849 
                 287650 
                 −0.33929018 
                   Homo sapiens  cDNA: 
               
               
                   
                   
                   
                   
                   
                 FLJ21196 fis, clone 
               
               
                   
                   
                   
                   
                   
                 COL00193 
               
               
                 Q8IYN2 
                 0 
                 AK026349 
                 288361 
                 0.32392521 
                   Homo sapiens  cDNA: 
               
               
                   
                   
                   
                   
                   
                 FLJ22696 fis, clone 
               
               
                   
                   
                   
                   
                   
                 HSI11696 
               
               
                 Q96ML0 
                 0 
                 AK056768 
                 310758 
                 −0.36516521 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ32206 fis, clone 
               
               
                   
                   
                   
                   
                   
                 PLACE6003109 
               
               
                 HSAC001114 
                 0 
                 AL137723 
                 5855 
                 −0.35802784 
                   Homo sapiens  mRNA; 
               
               
                   
                   
                   
                   
                   
                 cDNA 
               
               
                   
                   
                   
                   
                   
                 DKFZp434D0818 (from 
               
               
                   
                   
                   
                   
                   
                 clone 
               
               
                   
                   
                   
                   
                   
                 DKFZp434D0818) 
               
               
                 HSAC019203 
                 0 
                 AF339829 
                 326716 
                 −0.3385585 
                   Homo sapiens  clone 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 609847, mRNA 
               
               
                   
                   
                   
                   
                   
                 sequence 
               
               
                 IF42_HUMAN 
                 EIF4A2 
                 NM_001967 
                 173912 
                 0.32373865 
                 Eukaryotic translation 
               
               
                   
                   
                   
                   
                   
                 initiation factor 4A, 
               
               
                   
                   
                   
                   
                   
                 isoform 2 
               
               
                 HSAC013605 
                 0 
                 AL512697 
                 147587 
                 −0.3486998 
                   Homo sapiens  mRNA; 
               
               
                   
                   
                   
                   
                   
                 cDNA DKFZp547F134 
               
               
                   
                   
                   
                   
                   
                 (from clone 
               
               
                   
                   
                   
                   
                   
                 DKFZp547F134) 
               
               
                 Q96N43 
                 0 
                 AK055994 
                 28345 
                 −0.3643947 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ25084 fis, clone 
               
               
                   
                   
                   
                   
                   
                 CBL08511 
               
               
                 O94781 
                 LAMP3 
                 NM_014398 
                 10887 
                 −0.3448522 
                 Lysosomal-associated 
               
               
                   
                   
                   
                   
                   
                 membrane protein 3 
               
               
                 Q8N336 
                 DKFZp547C176 
                 AL359601 
                 48448 
                 −0.32503335 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 DKFZp547C176 
               
               
                 BAC1_HUMAN 
                 BACH1 
                 NM_001186 
                 154276 
                 −0.34061833 
                 BTB and CNC 
               
               
                   
                   
                   
                   
                   
                 homology 1, basic 
               
               
                   
                   
                   
                   
                   
                 leucine zipper 
               
               
                   
                   
                   
                   
                   
                 transcription factor 1 
               
               
                 G3P2_HUMAN 
                 GAPD 
                 NM_002046 
                 169476 
                 0.32785053 
                 Glyceraldehyde-3- 
               
               
                   
                   
                   
                   
                   
                 phosphate 
               
               
                   
                   
                   
                   
                   
                 dehydrogenase 
               
               
                 FX32_HUMAN 
                 0 
                 NM_058229 
                 61661 
                 0.30830001 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ32424 fis, clone 
               
               
                   
                   
                   
                   
                   
                 SKMUS2000954, 
               
               
                   
                   
                   
                   
                   
                 moderately similar to 
               
               
                   
                   
                   
                   
                   
                   Homo sapiens  F-box 
               
               
                   
                   
                   
                   
                   
                 protein 
               
               
                 DSC2_HUMAN 
                 DSC2 
                 NM_004949 
                 239727 
                 −0.34044888 
                 Desmocollin 2 
               
               
                 K2CE_HUMAN 
                 KRT6B 
                 NM_005555 
                 335952 
                 −0.31728346 
                 Keratin 6B 
               
               
                 ANXB_HUMAN 
                 ANXA11 
                 NM_001157 
                 75510 
                 −0.30741089 
                 Annexin A11 
               
               
                 Q9BZC1 
                 BRUNOL4 
                 NM_020180 
                 41641 
                 0.30753295 
                 Bruno-like 4, RNA 
               
               
                   
                   
                   
                   
                   
                 binding protein 
               
               
                   
                   
                   
                   
                   
                 ( Drosophila ) 
               
               
                 MYPH_HUMAN 
                 MYBPH 
                 NM_004997 
                 927 
                 0.28279614 
                 Myosin binding protein H 
               
               
                 ETFA_HUMAN 
                 ETFA 
                 NM_000126 
                 169919 
                 −0.31059939 
                 Electron-transfer- 
               
               
                   
                   
                   
                   
                   
                 flavoprotein, alpha 
               
               
                   
                   
                   
                   
                   
                 polypeptide (glutaric 
               
               
                   
                   
                   
                   
                   
                 aciduria II) 
               
               
                 EMP2_HUMAN 
                 EMP2 
                 NM_001424 
                 29191 
                 −0.31207607 
                 Epithelial membrane 
               
               
                   
                   
                   
                   
                   
                 protein 2 
               
               
                 O95712 
                 PLA2G4B 
                 NM_005090 
                 198161 
                 −0.37069629 
                 Phospholipase A2, 
               
               
                   
                   
                   
                   
                   
                 group IVB (cytosolic) 
               
               
                 HSAC020830 
                 0 
                 AK055817 
                 350833 
                 −0.30730506 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ31255 fis, clone 
               
               
                   
                   
                   
                   
                   
                 KIDNE2005603, 
               
               
                   
                   
                   
                   
                   
                 moderately similar to 2- 
               
               
                   
                   
                   
                   
                   
                 OXOGLUTARATE 
               
               
                   
                   
                   
                   
                   
                 DEHYDROGENA 
               
               
                 LOL1_HUMAN 
                 LOXL1 
                 NM_005576 
                 65436 
                 0.30369668 
                 Lysyl oxidase-like 1 
               
               
                 HSAC007550 
                 0 
                 AK056805 
                 162859 
                 0.30195444 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ32243 fis, clone 
               
               
                   
                   
                   
                   
                   
                 PROST1000039 
               
               
                 HPC1_HUMAN 
                 HPCAL1 
                 NM_002149 
                 3618 
                 −0.3406495 
                 Hippocalcin-like 1 
               
               
                 Q9H5G9 
                 FLJ23447 
                 NM_024825 
                 175024 
                 −0.34322107 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ23447 
               
               
                 RSG4_HUMAN 
                 RASAL1 
                 NM_004658 
                 198312 
                 −0.36721309 
                 RAS protein activator 
               
               
                   
                   
                   
                   
                   
                 like 1 (GAP1 like) 
               
               
                 HSAC009467 
                 0 
                 AK021980 
                 289068 
                 0.28867038 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ11918 fis, clone 
               
               
                   
                   
                   
                   
                   
                 HEMBB1000272 
               
               
                 Q9BXL5 
                 EDAG-1 
                 NM_018437 
                 176626 
                 −0.29674005 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 EDAG-1 
               
               
                 Q96HM7 
                 0 
                 BC016154 
                 350580 
                 0.32162091 
                 Homo sapiens, clone 
               
               
                   
                   
                   
                   
                   
                 MGC: 13247 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 4040497, 
               
               
                   
                   
                   
                   
                   
                 mRNA, complete cds 
               
               
                 HSAC014243 
                 0 
                 AK057730 
                 184050 
                 −0.34785224 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ25001 fis, clone 
               
               
                   
                   
                   
                   
                   
                 CBL00443 
               
               
                 Q9NSU6 
                 0 
                 AL137734 
                 149356 
                 −0.31041517 
                   Homo sapiens  mRNA; 
               
               
                   
                   
                   
                   
                   
                 cDNA 
               
               
                   
                   
                   
                   
                   
                 DKFZp586C0721 (from 
               
               
                   
                   
                   
                   
                   
                 clone 
               
               
                   
                   
                   
                   
                   
                 DKFZp586C0721); 
               
               
                   
                   
                   
                   
                   
                 partial cds 
               
               
                 Q9UHJ4 
                 KV8.1 
                 NM_014379 
                 13285 
                 −0.32573332 
                 Neuronal potassium 
               
               
                   
                   
                   
                   
                   
                 channel alpha subunit 
               
               
                 SPSY_HUMAN 
                 SMS 
                 NM_004595 
                 89718 
                 0.30387323 
                 Spermine synthase 
               
               
                 HSAC003848 
                 0 
                 AL050204 
                 28540 
                 −0.32209004 
                   Homo sapiens  mRNA; 
               
               
                   
                   
                   
                   
                   
                 cDNA 
               
               
                   
                   
                   
                   
                   
                 DKFZp586F1223 (from 
               
               
                   
                   
                   
                   
                   
                 clone 
               
               
                   
                   
                   
                   
                   
                 DKFZp586F1223) 
               
               
                 Q8NG17 
                 0 
                 AK057423 
                 344530 
                 −0.32147722 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ32861 fis, clone 
               
               
                   
                   
                   
                   
                   
                 TESTI2003589 
               
               
                 Q9Y6H1 
                 LOC51142 
                 NM_016139 
                 180859 
                 0.28850691 
                 16.7 Kd protein 
               
               
                 Q8TCZ2 
                 DKFZP761H2024 
                 NM_031462 
                 169388 
                 0.29944756 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 DKFZp761H2024 
               
               
                 MAT3_HUMAN 
                 MATR3 
                 NM_018834 
                 78825 
                 0.33085933 
                 Matrin 3 
               
               
                 TG37_HUMAN 
                 TG737 
                 NM_006531 
                 2291 
                 −0.31723327 
                 Probe hTg737 
               
               
                   
                   
                   
                   
                   
                 (polycystic kidney 
               
               
                   
                   
                   
                   
                   
                 disease, autosomal 
               
               
                   
                   
                   
                   
                   
                 recessive, in) 
               
               
                 TRIO_HUMAN 
                 TRIO 
                 NM_007118 
                 171957 
                 0.3112166 
                 Triple functional 
               
               
                   
                   
                   
                   
                   
                 domain (PTPRF 
               
               
                   
                   
                   
                   
                   
                 interacting) 
               
               
                 PIMT_HUMAN 
                 PCMT1 
                 NM_005389 
                 79137 
                 0.30318248 
                 Protein-L-isoaspartate 
               
               
                   
                   
                   
                   
                   
                 (D-aspartate) O- 
               
               
                   
                   
                   
                   
                   
                 methyltransferase 
               
               
                 HSAC018541 
                 0 
                 AK025055 
                 306756 
                 0.29732767 
                   Homo sapiens  cDNA: 
               
               
                   
                   
                   
                   
                   
                 FLJ21402 fis, clone 
               
               
                   
                   
                   
                   
                   
                 COL03734 
               
               
                 FXO4_HUMAN 
                 MLLT7 
                 NM_005938 
                 239663 
                 −0.3275796 
                 Myeloid/lymphoid or 
               
               
                   
                   
                   
                   
                   
                 mixed-lineage 
               
               
                   
                   
                   
                   
                   
                 leukemia (trithorax 
               
               
                   
                   
                   
                   
                   
                 homolog,  Drosophila ); 
               
               
                   
                   
                   
                   
                   
                 translocated to, 7 
               
               
                 HSAC005508 
                 LOC57099 
                 NM_020371 
                 63168 
                 −0.31221717 
                 Cell death regulator 
               
               
                   
                   
                   
                   
                   
                 aven 
               
               
                 HSAC013183 
                 0 
                 AL049328 
                 135642 
                 −0.30015385 
                   Homo sapiens  mRNA; 
               
               
                   
                   
                   
                   
                   
                 cDNA DKFZp564E026 
               
               
                   
                   
                   
                   
                   
                 (from clone 
               
               
                   
                   
                   
                   
                   
                 DKFZp564E026) 
               
               
                 JAK1_HUMAN 
                 JAK1 
                 NM_002227 
                 50651 
                 −0.32933441 
                 Janus kinase 1 (a 
               
               
                   
                   
                   
                   
                   
                 protein tyrosine kinase) 
               
               
                 HSAC018490 
                 0 
                 AK024712 
                 306702 
                 −0.32269088 
                   Homo sapiens  cDNA: 
               
               
                   
                   
                   
                   
                   
                 FLJ21059 fis, clone 
               
               
                   
                   
                   
                   
                   
                 CAS00740 
               
               
                 NHR1_HUMAN 
                 SLC9A3R1 
                 NM_004252 
                 184276 
                 −0.32298859 
                 Solute carrier family 9 
               
               
                   
                   
                   
                   
                   
                 (sodium/hydrogen 
               
               
                   
                   
                   
                   
                   
                 exchanger), isoform 3 
               
               
                   
                   
                   
                   
                   
                 regulatory factor 1 
               
               
                 HSAC018263 
                 0 
                 AL109730 
                 306331 
                 0.30249865 
                   Homo sapiens  mRNA 
               
               
                   
                   
                   
                   
                   
                 full length insert cDNA 
               
               
                   
                   
                   
                   
                   
                 clone EUROIMAGE 
               
               
                   
                   
                   
                   
                   
                 68600 
               
               
                 IRK3_HUMAN 
                 KCNJ3 
                 NM_002239 
                 37169 
                 −0.27575989 
                 Potassium inwardly- 
               
               
                   
                   
                   
                   
                   
                 rectifying channel, 
               
               
                   
                   
                   
                   
                   
                 subfamily J, member 3 
               
               
                 CTR1_HUMAN 
                 0 
                 AL050021 
                 14846 
                 −0.29584263 
                   Homo sapiens  mRNA; 
               
               
                   
                   
                   
                   
                   
                 cDNA DKFZp564D016 
               
               
                   
                   
                   
                   
                   
                 (from clone 
               
               
                   
                   
                   
                   
                   
                 DKFZp564D016) 
               
               
                 FAN_HUMAN 
                 NSMAF 
                 NM_003580 
                 78687 
                 0.31613497 
                 Neutral 
               
               
                   
                   
                   
                   
                   
                 sphingomyelinase (N- 
               
               
                   
                   
                   
                   
                   
                 SMase) activation 
               
               
                   
                   
                   
                   
                   
                 associated factor 
               
               
                 Q96NA9 
                 MEG3 
                 AK055725 
                 112844 
                 0.25180621 
                 Maternally expressed 3 
               
               
                 HSAC020071 
                 0 
                 AK057520 
                 345390 
                 −0.33442472 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ32958 fis, clone 
               
               
                   
                   
                   
                   
                   
                 TESTI2008234 
               
               
                 EML1_HUMAN 
                 EMAPL 
                 NM_004434 
                 12451 
                 0.29532372 
                 Echinoderm 
               
               
                   
                   
                   
                   
                   
                 microtubule-associated 
               
               
                   
                   
                   
                   
                   
                 protein-like 
               
               
                 O75915 
                 JWA 
                 NM_006407 
                 92384 
                 0.3125817 
                 Vitamin A responsive; 
               
               
                   
                   
                   
                   
                   
                 cytoskeleton related 
               
               
                 TRKB_HUMAN 
                 0 
                 AJ420458 
                 351930 
                 −0.30975194 
                   Homo sapiens  mRNA 
               
               
                   
                   
                   
                   
                   
                 full length insert cDNA 
               
               
                   
                   
                   
                   
                   
                 clone EUROIMAGE 
               
               
                   
                   
                   
                   
                   
                 1630957 
               
               
                 Q9P1S1 
                 FLJ10116 
                 NM_018000 
                 79741 
                 −0.30735296 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ10116 
               
               
                 Q96B21 
                 0 
                 BC016153 
                 283552 
                 −0.31888744 
                 Homo sapiens, Similar 
               
               
                   
                   
                   
                   
                   
                 to hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ10134, clone 
               
               
                   
                   
                   
                   
                   
                 MGC: 13208 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 3841102, 
               
               
                   
                   
                   
                   
                   
                 mRNA, complet 
               
               
                 RB3D_HUMAN 
                 GOV 
                 AF019226 
                 8036 
                 −0.30399168 
                 Glioblastoma 
               
               
                   
                   
                   
                   
                   
                 overexpressed 
               
               
                 CGD1_HUMAN 
                 CCND1 
                 NM_053056 
                 82932 
                 0.2829885 
                 Cyclin D1 (PRAD1: 
               
               
                   
                   
                   
                   
                   
                 parathyroid 
               
               
                   
                   
                   
                   
                   
                 adenomatosis 1) 
               
               
                 NPS1_HUMAN 
                 NIPSNAP1 
                 NM_003634 
                 173878 
                 0.29229903 
                 Nipsnap homolog 1 ( C. elegans ) 
               
               
                 COR3_HUMAN 
                 SPRR3 
                 NM_005416 
                 139322 
                 −0.33687812 
                 Small proline-rich 
               
               
                   
                   
                   
                   
                   
                 protein 3 
               
               
                 LDHA_HUMAN 
                 LDHA 
                 NM_005566 
                 2795 
                 0.30841977 
                 Lactate dehydrogenase A 
               
               
                 KPCI_HUMAN 
                 PRKCI 
                 NM_002740 
                 1904 
                 −0.32314399 
                 Protein kinase C, iota 
               
               
                 IF42_HUMAN 
                 EIF4A2 
                 NM_001967 
                 173912 
                 0.28965638 
                 Eukaryotic translation 
               
               
                   
                   
                   
                   
                   
                 initiation factor 4A, 
               
               
                   
                   
                   
                   
                   
                 isoform 2 
               
               
                 HSAC009161 
                 0 
                 AK026955 
                 287737 
                 0.30940785 
                   Homo sapiens  cDNA: 
               
               
                   
                   
                   
                   
                   
                 FLJ23302 fis, clone 
               
               
                   
                   
                   
                   
                   
                 HEP11143 
               
               
                 PLE1_HUMAN 
                 PLEC1 
                 NM_000445 
                 79706 
                 0.30274257 
                 Plectin 1, intermediate 
               
               
                   
                   
                   
                   
                   
                 filament binding 
               
               
                   
                   
                   
                   
                   
                 protein, 500 kD 
               
               
                 HSAC014877 
                 0 
                 BE961032 
                 200400 
                 −0.2926312 
                 Human DNA sequence 
               
               
                   
                   
                   
                   
                   
                 from BAC 15E1 on 
               
               
                   
                   
                   
                   
                   
                 chromosome 12. 
               
               
                   
                   
                   
                   
                   
                 Contains Cytochrome 
               
               
                   
                   
                   
                   
                   
                 C Oxidase Polypeptide 
               
               
                   
                   
                   
                   
                   
                 VIa-liv 
               
               
                 O94920 
                 KIAA0831 
                 NM_014924 
                 103000 
                 −0.34631714 
                 KIAA0831 protein 
               
               
                 ACBP_HUMAN 
                 DBI 
                 NM_020548 
                 78888 
                 −0.31289222 
                 Diazepam binding 
               
               
                   
                   
                   
                   
                   
                 inhibitor (GABA 
               
               
                   
                   
                   
                   
                   
                 receptor modulator, 
               
               
                   
                   
                   
                   
                   
                 acyl-Coenzyme A 
               
               
                   
                   
                   
                   
                   
                 binding protein) 
               
               
                 HSAC000440 
                 HBP17 
                 NM_005130 
                 1690 
                 −0.28350117 
                 Heparin-binding growth 
               
               
                   
                   
                   
                   
                   
                 factor binding protein 
               
               
                 MY10_HUMAN 
                 MYO10 
                 NM_012334 
                 61638 
                 0.28091339 
                 Myosin X 
               
               
                 CP2B_HUMAN 
                 CYP27B1 
                 NM_000785 
                 199270 
                 0.28232127 
                 Cytochrome P450, 
               
               
                   
                   
                   
                   
                   
                 subfamily XXVIIB (25- 
               
               
                   
                   
                   
                   
                   
                 hydroxyvitamin D-1- 
               
               
                   
                   
                   
                   
                   
                 alpha-hydroxylase), 
               
               
                   
                   
                   
                   
                   
                 polypeptide 1 
               
               
                 HSAC007525 
                 0 
                 AL133568 
                 161454 
                 0.27850204 
                   Homo sapiens  mRNA; 
               
               
                   
                   
                   
                   
                   
                 cDNA DKFZp434N197 
               
               
                   
                   
                   
                   
                   
                 (from clone 
               
               
                   
                   
                   
                   
                   
                 DKFZp434N197) 
               
               
                 Q9BV47 
                 MGC1136 
                 NM_024025 
                 8719 
                 0.27658422 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 MGC1136 
               
               
                 IHA_HUMAN 
                 INHA 
                 NM_002191 
                 1734 
                 0.28237705 
                 Inhibin, alpha 
               
               
                 COXM_HUMAN 
                 COX7B 
                 NM_001866 
                 75752 
                 −0.29046875 
                 Cytochrome c oxidase 
               
               
                   
                   
                   
                   
                   
                 subunit VIIb 
               
               
                 SM4D_HUMAN 
                 SEMA4D 
                 NM_006378 
                 79089 
                 −0.29092767 
                 Sema domain, 
               
               
                   
                   
                   
                   
                   
                 immunoglobulin 
               
               
                   
                   
                   
                   
                   
                 domain (Ig), 
               
               
                   
                   
                   
                   
                   
                 transmembrane 
               
               
                   
                   
                   
                   
                   
                 domain (TM) and short 
               
               
                   
                   
                   
                   
                   
                 cytoplasmic domain, 
               
               
                   
                   
                   
                   
                   
                 (se 
               
               
                 SZ06_HUMAN 
                 SCYB6 
                 NM_002993 
                 164021 
                 0.25934353 
                 Small inducible 
               
               
                   
                   
                   
                   
                   
                 cytokine subfamily B 
               
               
                   
                   
                   
                   
                   
                 (Cys-X-Cys), member 
               
               
                   
                   
                   
                   
                   
                 6 (granulocyte 
               
               
                   
                   
                   
                   
                   
                 chemotactic protein 2) 
               
               
                 DTNA_HUMAN 
                 0 
                 AK054766 
                 351299 
                 0.25246747 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ30204 fis, clone 
               
               
                   
                   
                   
                   
                   
                 BRACE2001496 
               
               
                 Q9H668 
                 FLJ22559 
                 NM_024928 
                 273387 
                 0.27961608 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ22559 
               
               
                 LDHA_HUMAN 
                 LDHA 
                 NM_005566 
                 2795 
                 0.30032227 
                 Lactate dehydrogenase A 
               
               
                 LDHA_HUMAN 
                 LDHA 
                 NM_005566 
                 2795 
                 0.30160612 
                 Lactate dehydrogenase A 
               
               
                 Q8NAZ8 
                 MAIL 
                 NM_031419 
                 301183 
                 −0.32420971 
                 Molecule possessing 
               
               
                   
                   
                   
                   
                   
                 ankyrin repeats 
               
               
                   
                   
                   
                   
                   
                 induced by 
               
               
                   
                   
                   
                   
                   
                 lipopolysaccharide 
               
               
                   
                   
                   
                   
                   
                 (MAIL), homolog of 
               
               
                   
                   
                   
                   
                   
                 mouse 
               
               
                 CBX3_HUMAN 
                 CBX3 
                 NM_016587 
                 278554 
                 0.28827974 
                 Chromobox homolog 3 
               
               
                   
                   
                   
                   
                   
                 (HP1 gamma homolog, 
               
               
                   
                   
                   
                   
                   
                   Drosophila ) 
               
               
                 CLF6_HUMAN 
                 FLJ20396 
                 NM_017801 
                 283685 
                 0.30443015 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ20396 
               
               
                 Q9Y4H4 
                 C6orf9 
                 NM_022107 
                 288316 
                 0.3070718 
                 Chromosome 6 open 
               
               
                   
                   
                   
                   
                   
                 reading frame 9 
               
               
                 HSAC018947 
                 FLJ10257 
                 AK001119 
                 321149 
                 0.25119607 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ10257 
               
               
                 O60687 
                 SRPUL 
                 NM_014467 
                 126782 
                 0.3005592 
                 Sushi-repeat protein 
               
               
                 ETV6_HUMAN 
                 ETV6 
                 NM_001987 
                 169081 
                 0.28814409 
                 Ets variant gene 6 
               
               
                   
                   
                   
                   
                   
                 (TEL oncogene) 
               
               
                 BIR2_HUMAN 
                 BIRC2 
                 NM_001166 
                 289107 
                 0.27998085 
                 Baculoviral IAP repeat- 
               
               
                   
                   
                   
                   
                   
                 containing 2 
               
               
                 IRS2_HUMAN 
                 IRS2 
                 AF073310 
                 143648 
                 0.26611452 
                 Insulin receptor 
               
               
                   
                   
                   
                   
                   
                 substrate 2 
               
               
                 L10K_HUMAN 
                 HSPC023 
                 NM_014047 
                 279945 
                 0.28479353 
                 HSPC023 protein 
               
               
                 HSAC017376 
                 0 
                 BF541376 
                 278937 
                 0.27795661 
                 ESTs, Weakly similar 
               
               
                   
                   
                   
                   
                   
                 to FRHUL ferritin light 
               
               
                   
                   
                   
                   
                   
                 chain [ H. sapiens ] 
               
               
                 LDHA_HUMAN 
                 LDHA 
                 NM_005566 
                 2795 
                 0.29743949 
                 Lactate dehydrogenase A 
               
               
                 D103_HUMAN 
                 DEFB3 
                 NM_018661 
                 283082 
                 −0.32396031 
                 Defensin, beta 3 
               
               
                 Q9BUC9 
                 DAP 
                 NM_004394 
                 75189 
                 0.30044109 
                 Death-associated 
               
               
                   
                   
                   
                   
                   
                 protein 
               
               
                 Q9BSU0 
                 FLJ22457 
                 NM_024901 
                 238707 
                 −0.29867151 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ22457 
               
               
                 LDHA_HUMAN 
                 LDHA 
                 NM_005566 
                 2795 
                 0.29428289 
                 Lactate dehydrogenase A 
               
               
                 TPTE_HUMAN 
                 TPTE 
                 NM_013315 
                 122986 
                 0.29338232 
                 Transmembrane 
               
               
                   
                   
                   
                   
                   
                 phosphatase with 
               
               
                   
                   
                   
                   
                   
                 tensin homology 
               
               
                 HSAC018269 
                 0 
                 AL110206 
                 306339 
                 0.29149163 
                   Homo sapiens  mRNA; 
               
               
                   
                   
                   
                   
                   
                 cDNA 
               
               
                   
                   
                   
                   
                   
                 DKFZp586N2022 (from 
               
               
                   
                   
                   
                   
                   
                 clone 
               
               
                   
                   
                   
                   
                   
                 DKFZp586N2022) 
               
               
                 Q8WWY3 
                 PRPF31 
                 NM_015629 
                 183438 
                 0.28992597 
                 PRP31 pre-mRNA 
               
               
                   
                   
                   
                   
                   
                 processing factor 31 
               
               
                   
                   
                   
                   
                   
                 homolog (yeast) 
               
               
                 Q9NWG1 
                 SDCCAG1 
                 NM_004713 
                 54900 
                 0.27325851 
                 Serologically defined 
               
               
                   
                   
                   
                   
                   
                 colon cancer antigen 1 
               
               
                 ID1_HUMAN 
                 ID1 
                 NM_002165 
                 75424 
                 −0.30300715 
                 Inhibitor of DNA 
               
               
                   
                   
                   
                   
                   
                 binding 1, dominant 
               
               
                   
                   
                   
                   
                   
                 negative helix-loop- 
               
               
                   
                   
                   
                   
                   
                 helix protein 
               
               
                 HSAC018258 
                 0 
                 AL080208 
                 306325 
                 −0.32407958 
                   Homo sapiens  mRNA; 
               
               
                   
                   
                   
                   
                   
                 cDNA 
               
               
                   
                   
                   
                   
                   
                 DKFZp586C1523 (from 
               
               
                   
                   
                   
                   
                   
                 clone 
               
               
                   
                   
                   
                   
                   
                 DKFZp586C1523) 
               
               
                 E2F5_HUMAN 
                 E2F5 
                 NM_001951 
                 2331 
                 −0.32253572 
                 E2F transcription factor 
               
               
                   
                   
                   
                   
                   
                 5, p130-binding 
               
               
                 GPX7_HUMAN 
                 CL683 
                 NM_015696 
                 43728 
                 0.27876425 
                 Weakly similar to 
               
               
                   
                   
                   
                   
                   
                 glutathione peroxidase 2 
               
               
                 AMD1_HUMAN 
                 AMPD1 
                 NM_000036 
                 89570 
                 0.30648359 
                 Adenosine 
               
               
                   
                   
                   
                   
                   
                 monophosphate 
               
               
                   
                   
                   
                   
                   
                 deaminase 1 (isoform 
               
               
                   
                   
                   
                   
                   
                 M) 
               
               
                 SDC1_HUMAN 
                 SDC1 
                 NM_002997 
                 82109 
                 −0.29681828 
                 Syndecan 1 
               
               
                 HSAC010708 
                 FLJ10852 
                 NM_019028 
                 95744 
                 −0.27932774 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 similar to ankyrin 
               
               
                   
                   
                   
                   
                   
                 repeat-containing 
               
               
                   
                   
                   
                   
                   
                 priotein AKR1 
               
               
                 HSAC016387 
                 0 
                 AK023404 
                 255890 
                 −0.30644116 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ13342 fis, clone 
               
               
                   
                   
                   
                   
                   
                 OVARC1001950 
               
               
                 MU81_HUMAN 
                 MUS81 
                 NM_025128 
                 288798 
                 0.30225775 
                 MUS81 endonuclease 
               
               
                 LDHA_HUMAN 
                 LDHA 
                 NM_005566 
                 2795 
                 0.29433701 
                 Lactate dehydrogenase A 
               
               
                 NFC2_HUMAN 
                 NFATC2 
                 NM_012340 
                 248037 
                 −0.28597821 
                 Nuclear factor of 
               
               
                   
                   
                   
                   
                   
                 activated T-cells, 
               
               
                   
                   
                   
                   
                   
                 cytoplasmic, 
               
               
                   
                   
                   
                   
                   
                 calcineurin-dependent 2 
               
               
                 CAV2_HUMAN 
                 CAV2 
                 NM_001233 
                 139851 
                 0.28575252 
                 Caveolin 2 
               
               
                 HSAC012923 
                 0 
                 AK024243 
                 130874 
                 −0.30558024 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ14181 fis, clone 
               
               
                   
                   
                   
                   
                   
                 NT2RP2004300 
               
               
                 RAG2_HUMAN 
                 RAG2 
                 AF080577 
                 159376 
                 0.27054284 
                 Recombination 
               
               
                   
                   
                   
                   
                   
                 activating gene 2 
               
               
                 HSAC001602 
                 TOM1L2 
                 AK055959 
                 8125 
                 −0.30209679 
                 Target of myb1-like 2 
               
               
                   
                   
                   
                   
                   
                 (chicken) 
               
               
                 HSAC013938 
                 FLJ11585 
                 NM_023075 
                 154145 
                 −0.27045129 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ11585 
               
               
                 WNT3_HUMAN 
                 WNT3 
                 NM_030753 
                 224667 
                 −0.22616384 
                 Wingless-type MMTV 
               
               
                   
                   
                   
                   
                   
                 integration site family, 
               
               
                   
                   
                   
                   
                   
                 member 3 
               
               
                 P02570 
                 ACTB 
                 NM_001101 
                 288061 
                 0.30930373 
                 Actin, beta 
               
               
                 Y469_HUMAN 
                 KIAA0469 
                 NM_014851 
                 7764 
                 −0.27875891 
                 KIAA0469 gene 
               
               
                   
                   
                   
                   
                   
                 product 
               
               
                 ALDR_HUMAN 
                 AKR1B1 
                 NM_001628 
                 75313 
                 0.24791515 
                 Aldo-keto reductase 
               
               
                   
                   
                   
                   
                   
                 family 1, member B1 
               
               
                   
                   
                   
                   
                   
                 (aldose reductase) 
               
               
                 HSAC003731 
                 0 
                 AK023559 
                 27091 
                 −0.30440343 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ13497 fis, clone 
               
               
                   
                   
                   
                   
                   
                 PLACE1004518 
               
               
                 Q9Y605 
                 PGR1 
                 NM_033296 
                 285902 
                 0.23312692 
                 T-cell activation protein 
               
               
                 KFP3_HUMAN 
                 KIFAP3 
                 NM_014970 
                 171374 
                 0.29438383 
                 Kinesin-associated 
               
               
                   
                   
                   
                   
                   
                 protein 3 
               
               
                 LDHA_HUMAN 
                 LDHA 
                 NM_005566 
                 2795 
                 0.29008023 
                 Lactate dehydrogenase A 
               
               
                 HSAC016288 
                 0 
                 AL080073 
                 251414 
                 −0.27036219 
                   Homo sapiens  mRNA; 
               
               
                   
                   
                   
                   
                   
                 cDNA 
               
               
                   
                   
                   
                   
                   
                 DKFZp564B1462 (from 
               
               
                   
                   
                   
                   
                   
                 clone 
               
               
                   
                   
                   
                   
                   
                 DKFZp564B1462) 
               
               
                 HSAC003517 
                 0 
                 AL133611 
                 25362 
                 −0.29482254 
                   Homo sapiens  mRNA; 
               
               
                   
                   
                   
                   
                   
                 cDNA 
               
               
                   
                   
                   
                   
                   
                 DKFZp434O1317 (from 
               
               
                   
                   
                   
                   
                   
                 clone 
               
               
                   
                   
                   
                   
                   
                 DKFZp434O1317) 
               
               
                 CPG2_HUMAN 
                 LOC51137 
                 NM_016128 
                 102950 
                 −0.27178678 
                 Coat protein gamma- 
               
               
                   
                   
                   
                   
                   
                 cop 
               
               
                 TS22_HUMAN 
                 TSC22 
                 AK027071 
                 114360 
                 0.2800433 
                 Transforming growth 
               
               
                   
                   
                   
                   
                   
                 factor beta-stimulated 
               
               
                   
                   
                   
                   
                   
                 protein TSC-22 
               
               
                 S108_HUMAN 
                 S100A8 
                 NM_002964 
                 100000 
                 −0.30596008 
                 S100 calcium binding 
               
               
                   
                   
                   
                   
                   
                 protein A8 (calgranulin 
               
               
                   
                   
                   
                   
                   
                 A) 
               
               
                 GLGB_HUMAN 
                 GBE1 
                 NM_000158 
                 1691 
                 −0.28462395 
                 Glucan (1,4-alpha-), 
               
               
                   
                   
                   
                   
                   
                 branching enzyme 1 
               
               
                   
                   
                   
                   
                   
                 (glycogen branching 
               
               
                   
                   
                   
                   
                   
                 enzyme, Andersen 
               
               
                   
                   
                   
                   
                   
                 disease, glycogen 
               
               
                   
                   
                   
                   
                   
                 stora 
               
               
                 TCPZ_HUMAN 
                 CCT6A 
                 NM_001762 
                 82916 
                 0.26946642 
                 Chaperonin containing 
               
               
                   
                   
                   
                   
                   
                 TCP1, subunit 6A (zeta 
               
               
                   
                   
                   
                   
                   
                 1) 
               
               
                 NUDM_HUMAN 
                 NDUFA10 
                 NM_004544 
                 198271 
                 0.26779732 
                 NADH dehydrogenase 
               
               
                   
                   
                   
                   
                   
                 (ubiquinone) 1 alpha 
               
               
                   
                   
                   
                   
                   
                 subcomplex, 10 (42 kD) 
               
               
                 Q9P005 
                 HSPC159 
                 NM_014181 
                 114771 
                 −0.29780343 
                 HSPC159 protein 
               
               
                 HSAC013665 
                 0 
                 BC009462 
                 149596 
                 −0.30540195 
                 Homo sapiens, Similar 
               
               
                   
                   
                   
                   
                   
                 to RIKEN cDNA 
               
               
                   
                   
                   
                   
                   
                 2310038H17 gene, 
               
               
                   
                   
                   
                   
                   
                 clone MGC: 15974 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 3542748, 
               
               
                   
                   
                   
                   
                   
                 mRNA, complete c 
               
               
                 LDHA_HUMAN 
                 LDHA 
                 NM_005566 
                 2795 
                 0.29038588 
                 Lactate dehydrogenase A 
               
               
                 Q96B64 
                 C1orf29 
                 NM_006820 
                 75470 
                 −0.28141634 
                 Chromosome 1 open 
               
               
                   
                   
                   
                   
                   
                 reading frame 29 
               
               
                 OSB2_HUMAN 
                 OSBP2 
                 AF288741 
                 7740 
                 −0.2741057 
                 Oxysterol binding 
               
               
                   
                   
                   
                   
                   
                 protein 2 
               
               
                 IMD2_HUMAN 
                 IMPDH2 
                 NM_000884 
                 75432 
                 0.25505345 
                 IMP (inosine 
               
               
                   
                   
                   
                   
                   
                 monophosphate) 
               
               
                   
                   
                   
                   
                   
                 dehydrogenase 2 
               
               
                 NID2_HUMAN 
                 NID2 
                 NM_007361 
                 82733 
                 0.2691638 
                 Nidogen 2 
               
               
                 HSAC019850 
                 0 
                 AJ420542 
                 339283 
                 −0.30808045 
                   Homo sapiens  mRNA 
               
               
                   
                   
                   
                   
                   
                 full length insert cDNA 
               
               
                   
                   
                   
                   
                   
                 clone EUROIMAGE 
               
               
                   
                   
                   
                   
                   
                 1090104 
               
               
                 Q8WW54 
                 LOC51326 
                 NM_016632 
                 264509 
                 0.27687084 
                 ARF protein 
               
               
                 ELM1_HUMAN 
                 ELMO1 
                 AL136787 
                 31463 
                 −0.27259252 
                 Engulfment and cell 
               
               
                   
                   
                   
                   
                   
                 motility 1 (ced-12 
               
               
                   
                   
                   
                   
                   
                 homolog,  C. elegans ) 
               
               
                 HSAC014487 
                 KIAA1733 
                 AB051520 
                 191979 
                 −0.26781459 
                 KIAA1733 protein 
               
               
                 ENOB_HUMAN 
                 ENO3 
                 NM_001976 
                 118804 
                 0.26094659 
                 Enolase 3, (beta, 
               
               
                   
                   
                   
                   
                   
                 muscle) 
               
               
                 LDHA_HUMAN 
                 LDHA 
                 NM_005566 
                 2795 
                 0.29558421 
                 Lactate dehydrogenase A 
               
               
                 OM07_HUMAN 
                 LOC54543 
                 AK027539 
                 112318 
                 0.28422476 
                 6.2 kd protein 
               
               
                 HSAC003197 
                 0 
                 AK025726 
                 22867 
                 −0.28883729 
                   Homo sapiens  cDNA: 
               
               
                   
                   
                   
                   
                   
                 FLJ22073 fis, clone 
               
               
                   
                   
                   
                   
                   
                 HEP11868 
               
               
                 Q92922 
                 SMARCC1 
                 NM_003074 
                 172280 
                 −0.28726269 
                 SWI/SNF related, 
               
               
                   
                   
                   
                   
                   
                 matrix associated, actin 
               
               
                   
                   
                   
                   
                   
                 dependent regulator of 
               
               
                   
                   
                   
                   
                   
                 chromatin, subfamily c, 
               
               
                   
                   
                   
                   
                   
                 member 1 
               
               
                 Q9Y2F1 
                 KIAA0942 
                 NM_015310 
                 6763 
                 −0.28114819 
                 KIAA0942 protein 
               
               
                 SIVA_HUMAN 
                 SIVA 
                 NM_006427 
                 112058 
                 0.2653505 
                 CD27-binding (Siva) 
               
               
                   
                   
                   
                   
                   
                 protein 
               
               
                 LMA3_HUMAN 
                 LAMA3 
                 NM_000227 
                 83450 
                 0.25310579 
                 Laminin, alpha 3 
               
               
                   
                   
                   
                   
                   
                 (nicein (150 kD), kalinin 
               
               
                   
                   
                   
                   
                   
                 (165 kD), BM600 
               
               
                   
                   
                   
                   
                   
                 (150 kD), epilegrin) 
               
               
                 HSAC010931 
                 0 
                 AK054565 
                 99014 
                 0.2461665 
                   Homo sapiens , clone 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 3632168, 
               
               
                   
                   
                   
                   
                   
                 mRNA 
               
               
                 ALM1_HUMAN 
                 ABLIM 
                 NM_002313 
                 158203 
                 −0.29500492 
                 Actin binding LIM 
               
               
                   
                   
                   
                   
                   
                 protein 
               
               
                 TKNK_HUMAN 
                 TAC3 
                 NM_013251 
                 9730 
                 0.2856172 
                 Tachykinin 3 
               
               
                   
                   
                   
                   
                   
                 (neuromedin K, 
               
               
                   
                   
                   
                   
                   
                 neurokinin beta) 
               
               
                 HPS3_HUMAN 
                 HPS3 
                 AY033141 
                 282804 
                 −0.32252959 
                 Hermansky-Pudlak 
               
               
                   
                   
                   
                   
                   
                 syndrome 3 
               
               
                 HSAC021198 
                 0 
                 AK055550 
                 351640 
                 −0.2982647 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ30988 fis, clone 
               
               
                   
                   
                   
                   
                   
                 HLUNG1000030 
               
               
                 Q9H657 
                 FLJ22593 
                 NM_024703 
                 101265 
                 0.28723669 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ22593 
               
               
                 Q14244 
                 MAP7 
                 NM_003980 
                 146388 
                 −0.26283399 
                 Microtubule-associated 
               
               
                   
                   
                   
                   
                   
                 protein 7 
               
               
                 SPB7_HUMAN 
                 SERPINB7 
                 NM_003784 
                 138202 
                 −0.33063598 
                 Serine (or cysteine) 
               
               
                   
                   
                   
                   
                   
                 proteinase inhibitor, 
               
               
                   
                   
                   
                   
                   
                 clade B (ovalbumin), 
               
               
                   
                   
                   
                   
                   
                 member 7 
               
               
                 TR1A_HUMAN 
                 TNFRSF1A 
                 NM_001065 
                 159 
                 0.28778288 
                 Tumor necrosis factor 
               
               
                   
                   
                   
                   
                   
                 receptor superfamily, 
               
               
                   
                   
                   
                   
                   
                 member 1A 
               
               
                 TPP2_HUMAN 
                 TPP2 
                 NM_003291 
                 1117 
                 −0.28378443 
                 Tripeptidyl peptidase II 
               
               
                 RU17_HUMAN 
                 SNRP70 
                 NM_003089 
                 174051 
                 0.30742876 
                 Small nuclear 
               
               
                   
                   
                   
                   
                   
                 ribonucleoprotein 70 kD 
               
               
                   
                   
                   
                   
                   
                 polypeptide (RNP 
               
               
                   
                   
                   
                   
                   
                 antigen) 
               
               
                 RB6A_HUMAN 
                 RAB6A 
                 AK057157 
                 5636 
                 −0.3002715 
                 RAB6A, member RAS 
               
               
                   
                   
                   
                   
                   
                 oncogene family 
               
               
                 NDKB_HUMAN 
                 NME2 
                 NM_002512 
                 275163 
                 0.27328053 
                 Non-metastatic cells 2, 
               
               
                   
                   
                   
                   
                   
                 protein (NM23B) 
               
               
                   
                   
                   
                   
                   
                 expressed in 
               
               
                 KU70_HUMAN 
                 G22P1 
                 NM_001469 
                 197345 
                 0.27324664 
                 Thyroid autoantigen 
               
               
                   
                   
                   
                   
                   
                 70 kD (Ku antigen) 
               
               
                 Q8IVU3 
                 FLJ20637 
                 NM_017912 
                 179669 
                 −0.27130275 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ20637 
               
               
                 TPSN_HUMAN 
                 TAPBP 
                 AF029750 
                 179600 
                 −0.26528001 
                 TAP binding protein 
               
               
                   
                   
                   
                   
                   
                 (tapasin) 
               
               
                 ZEP1_HUMAN 
                 HIVEP1 
                 NM_002114 
                 306 
                 0.25935225 
                 Human 
               
               
                   
                   
                   
                   
                   
                 immunodeficiency virus 
               
               
                   
                   
                   
                   
                   
                 type I enhancer binding 
               
               
                   
                   
                   
                   
                   
                 protein 1 
               
               
                 Q9H8B3 
                 0 
                 AK023854 
                 154751 
                 −0.28222739 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ13792 fis, clone 
               
               
                   
                   
                   
                   
                   
                 THYRO1000072, 
               
               
                   
                   
                   
                   
                   
                 weakly similar to 
               
               
                   
                   
                   
                   
                   
                 MYOSIN LIGHT 
               
               
                   
                   
                   
                   
                   
                 CHAIN KINASE, SMO 
               
               
                 HSAC018635 
                 0 
                 AK026731 
                 306873 
                 −0.26370149 
                   Homo sapiens  cDNA: 
               
               
                   
                   
                   
                   
                   
                 FLJ23078 fis, clone 
               
               
                   
                   
                   
                   
                   
                 LNG05870 
               
               
                 HSAC018455 
                 0 
                 AK024098 
                 306663 
                 −0.25828945 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ14036 fis, clone 
               
               
                   
                   
                   
                   
                   
                 HEMBA1004709 
               
               
                 ECG2_HUMAN 
                 ECG2 
                 NM_032566 
                 244569 
                 −0.36634539 
                 Esophagus cancer- 
               
               
                   
                   
                   
                   
                   
                 related gene-2 
               
               
                 DLK_HUMAN 
                 DLK1 
                 NM_003836 
                 169228 
                 −0.29226303 
                 Delta-like 1 homolog 
               
               
                   
                   
                   
                   
                   
                 ( Drosophila ) 
               
               
                 LDHA_HUMAN 
                 LDHA 
                 NM_005566 
                 2795 
                 0.29093325 
                 Lactate dehydrogenase A 
               
               
                 CRTC_HUMAN 
                 CALR 
                 NM_004343 
                 16488 
                 0.26036309 
                 Calreticulin 
               
               
                 HSAC013371 
                 LOC51087 
                 NM_015982 
                 142989 
                 0.2559957 
                 Germ cell specific Y- 
               
               
                   
                   
                   
                   
                   
                 box binding protein 
               
               
                 HSAC011127 
                 0 
                 AL133645 
                 101651 
                 −0.30011435 
                   Homo sapiens  mRNA; 
               
               
                   
                   
                   
                   
                   
                 cDNA DKFZp434C107 
               
               
                   
                   
                   
                   
                   
                 (from clone 
               
               
                   
                   
                   
                   
                   
                 DKFZp434C107) 
               
               
                 BAA09603 
                 DJ-1 
                 NM_007262 
                 10958 
                 0.2951662 
                 RNA-binding protein 
               
               
                   
                   
                   
                   
                   
                 regulatory subunit 
               
               
                 ATF7_HUMAN 
                 ATF7 
                 NM_006856 
                 55888 
                 −0.28947132 
                 Activating transcription 
               
               
                   
                   
                   
                   
                   
                 factor 7 
               
               
                 RHG6_HUMAN 
                 ARHGAP6 
                 NM_001174 
                 250830 
                 −0.28626769 
                 Rho GTPase activating 
               
               
                   
                   
                   
                   
                   
                 protein 6 
               
               
                 EPOR_HUMAN 
                 EPOR 
                 NM_000121 
                 89548 
                 −0.27351061 
                 Erythropoietin receptor 
               
               
                 SN23_HUMAN 
                 SNAP23 
                 BC003686 
                 184376 
                 0.26960802 
                 Synaptosomal- 
               
               
                   
                   
                   
                   
                   
                 associated protein, 
               
               
                   
                   
                   
                   
                   
                 23 kD 
               
               
                 HSAC018299 
                 0 
                 AK000293 
                 306391 
                 −0.26323331 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ20286 fis, clone 
               
               
                   
                   
                   
                   
                   
                 HEP04358 
               
               
                 AMD_HUMAN 
                 PAM 
                 NM_000919 
                 83920 
                 0.2573707 
                 Peptidylglycine alpha- 
               
               
                   
                   
                   
                   
                   
                 amidating 
               
               
                   
                   
                   
                   
                   
                 monooxygenase 
               
               
                 MAGC_HUMAN 
                 MAGEA12 
                 NM_005367 
                 169246 
                 0.23080255 
                 Melanoma antigen, 
               
               
                   
                   
                   
                   
                   
                 family A, 12 
               
               
                 HSAC011887 
                 0 
                 AK021693 
                 113660 
                 0.28054849 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ11631 fis, clone 
               
               
                   
                   
                   
                   
                   
                 HEMBA1004267 
               
               
                 HSAC002243 
                 0 
                 U80766 
                 13252 
                 0.28054079 
                 Human EST clone 
               
               
                   
                   
                   
                   
                   
                 22453 mariner 
               
               
                   
                   
                   
                   
                   
                 transposon Hsmar1 
               
               
                   
                   
                   
                   
                   
                 sequence 
               
               
                 LDHA_HUMAN 
                 LDHA 
                 NM_005566 
                 2795 
                 0.28016177 
                 Lactate dehydrogenase A 
               
               
                 HSAC015540 
                 0 
                 AK021431 
                 235543 
                 −0.27184922 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ11369 fis, clone 
               
               
                   
                   
                   
                   
                   
                 HEMBA1000338 
               
               
                 VTNC_HUMAN 
                 VTN 
                 NM_000638 
                 2257 
                 0.26296734 
                 Vitronectin (serum 
               
               
                   
                   
                   
                   
                   
                 spreading factor, 
               
               
                   
                   
                   
                   
                   
                 somatomedin B, 
               
               
                   
                   
                   
                   
                   
                 complement S-protein) 
               
               
                 RS4Y_HUMAN 
                 RPS4Y 
                 NM_001008 
                 180911 
                 0.25349604 
                 Ribosomal protein S4, 
               
               
                   
                   
                   
                   
                   
                 Y-linked 
               
               
                 Q9NXV4 
                 FLJ20038 
                 AL117436 
                 72071 
                 0.2341145 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ20038 
               
               
                 LDHA_HUMAN 
                 LDHA 
                 NM_005566 
                 2795 
                 0.28721692 
                 Lactate dehydrogenase A 
               
               
                 RT36_HUMAN 
                 MRPS36 
                 NM_033281 
                 41182 
                 −0.27224936 
                 Mitochondrial 
               
               
                   
                   
                   
                   
                   
                 ribosomal protein S36 
               
               
                 HSAC016670 
                 0 
                 AF127771 
                 269645 
                 −0.24620011 
                   Homo sapiens  cell-line 
               
               
                   
                   
                   
                   
                   
                 E8CASS clone E24L 
               
               
                   
                   
                   
                   
                   
                 estradiol-induced 
               
               
                   
                   
                   
                   
                   
                 mRNA sequence 
               
               
                 HS71_HUMAN 
                 HSPA1A 
                 NM_005345 
                 8997 
                 0.23168516 
                 Heat shock 70 kD 
               
               
                   
                   
                   
                   
                   
                 protein 1A 
               
               
                 SPCQ_HUMAN 
                 SPTBN4 
                 NM_025213 
                 32706 
                 −0.3053758 
                 Spectrin, beta, non- 
               
               
                   
                   
                   
                   
                   
                 erythrocytic 4 
               
               
                 Q00007 
                 PPP2R2A 
                 NM_002717 
                 179574 
                 −0.29293379 
                 Protein phosphatase 2 
               
               
                   
                   
                   
                   
                   
                 (formerly 2A), 
               
               
                   
                   
                   
                   
                   
                 regulatory subunit B 
               
               
                   
                   
                   
                   
                   
                 (PR 52), alpha isoform 
               
               
                 P02570 
                 ACTB 
                 NM_001101 
                 288061 
                 0.28900489 
                 Actin, beta 
               
               
                 PSS1_HUMAN 
                 PTDSS1 
                 NM_014754 
                 77329 
                 0.27454166 
                 Phosphatidylserine 
               
               
                   
                   
                   
                   
                   
                 synthase 1 
               
               
                 RBP1_HUMAN 
                 RALBP1 
                 NM_006788 
                 75447 
                 −0.26200162 
                 RalA binding protein 1 
               
               
                 Q86WL8 
                 0 
                 AK055310 
                 65771 
                 −0.25500063 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ30748 fis, clone 
               
               
                   
                   
                   
                   
                   
                 FEBRA2000399, 
               
               
                   
                   
                   
                   
                   
                 moderately similar to 
               
               
                   
                   
                   
                   
                   
                 ZINC FINGER 
               
               
                   
                   
                   
                   
                   
                 PROTEIN 45 
               
               
                 HSAC017300 
                 0 
                 AL137712 
                 278565 
                 0.24979685 
                   Homo sapiens  mRNA; 
               
               
                   
                   
                   
                   
                   
                 cDNA 
               
               
                   
                   
                   
                   
                   
                 DKFZp434H0923 (from 
               
               
                   
                   
                   
                   
                   
                 clone 
               
               
                   
                   
                   
                   
                   
                 DKFZp434H0923) 
               
               
                 SPL1_HUMAN 
                 SPARCL1 
                 NM_004684 
                 75445 
                 0.26009914 
                 SPARC-like 1 (mast9, 
               
               
                   
                   
                   
                   
                   
                 hevin) 
               
               
                 Q13018 
                 PLA2R1 
                 U17033 
                 171945 
                 −0.25693813 
                 Phospholipase A2 
               
               
                   
                   
                   
                   
                   
                 receptor 1, 180 kD 
               
               
                 Q9NPE2 
                 NEUGRIN 
                 NM_016645 
                 323467 
                 0.23781654 
                 Mesenchymal stem cell 
               
               
                   
                   
                   
                   
                   
                 protein DSC92 
               
               
                 Q9H652 
                 MGC4171 
                 NM_024307 
                 289015 
                 −0.32024804 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 MGC4171 
               
               
                 K22E_HUMAN 
                 KRT2A 
                 NM_000423 
                 707 
                 −0.2888545 
                 Keratin 2A (epidermal 
               
               
                   
                   
                   
                   
                   
                 ichthyosis bullosa of 
               
               
                   
                   
                   
                   
                   
                 Siemens) 
               
               
                 KPT2_HUMAN 
                 PCTK2 
                 NM_002595 
                 183302 
                 −0.28303243 
                 PCTAIRE protein 
               
               
                   
                   
                   
                   
                   
                 kinase 2 
               
               
                 Q96B23 
                 0 
                 BC016149 
                 33862 
                 −0.27418789 
                   Homo sapiens , clone 
               
               
                   
                   
                   
                   
                   
                 MGC: 12909 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 4040087, 
               
               
                   
                   
                   
                   
                   
                 mRNA, complete cds 
               
               
                 DAF_HUMAN 
                 DAF 
                 NM_000574 
                 1369 
                 −0.27270806 
                 Decay accelerating 
               
               
                   
                   
                   
                   
                   
                 factor for complement 
               
               
                   
                   
                   
                   
                   
                 (CD55, Cromer blood 
               
               
                   
                   
                   
                   
                   
                 group system) 
               
               
                 Q09753 
                 DEFB1 
                 NM_005218 
                 32949 
                 −0.26188185 
                 Defensin, beta 1 
               
               
                 HSAC001158 
                 0 
                 AK026673 
                 6127 
                 0.25225961 
                   Homo sapiens  cDNA: 
               
               
                   
                   
                   
                   
                   
                 FLJ23020 fis, clone 
               
               
                   
                   
                   
                   
                   
                 LNG00943 
               
               
                 DECR_HUMAN 
                 DECR1 
                 NM_001359 
                 81548 
                 0.24937384 
                 2,4-dienoyl CoA 
               
               
                   
                   
                   
                   
                   
                 reductase 1, 
               
               
                   
                   
                   
                   
                   
                 mitochondrial 
               
               
                 CIT2_HUMAN 
                 CITED2 
                 AF109161 
                 82071 
                 −0.24627852 
                 Cbp/p300-interacting 
               
               
                   
                   
                   
                   
                   
                 transactivator, with 
               
               
                   
                   
                   
                   
                   
                 Glu/Asp-rich carboxy- 
               
               
                   
                   
                   
                   
                   
                 terminal domain, 2 
               
               
                 IPO4_HUMAN 
                 FLJ23338 
                 NM_024658 
                 61790 
                 0.21814335 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ23338 
               
               
                 HSAC009416 
                 0 
                 AK023616 
                 288949 
                 0.27291917 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ13554 fis, clone 
               
               
                   
                   
                   
                   
                   
                 PLACE1007478 
               
               
                 SPEE_HUMAN 
                 SRM 
                 NM_003132 
                 76244 
                 0.26205253 
                 Spermidine synthase 
               
               
                 GLT2_HUMAN 
                 GALNT2 
                 NM_004481 
                 130181 
                 0.25166558 
                 UDP-N-acetyl-alpha-D- 
               
               
                   
                   
                   
                   
                   
                 galactosamine:polypeptide 
               
               
                   
                   
                   
                   
                   
                 N- 
               
               
                   
                   
                   
                   
                   
                 acetylgalactosaminyltransferase 
               
               
                   
                   
                   
                   
                   
                 2 (GalNAc- 
               
               
                   
                   
                   
                   
                   
                 T2) 
               
               
                 EF1G_HUMAN 
                 EEF1G 
                 BC004215 
                 2186 
                 0.24251596 
                 Eukaryotic translation 
               
               
                   
                   
                   
                   
                   
                 elongation factor 1 
               
               
                   
                   
                   
                   
                   
                 gamma 
               
               
                 IF42_HUMAN 
                 EIF4A2 
                 NM_001967 
                 173912 
                 0.22487428 
                 Eukaryotic translation 
               
               
                   
                   
                   
                   
                   
                 initiation factor 4A, 
               
               
                   
                   
                   
                   
                   
                 isoform 2 
               
               
                 Q9P221 
                 FLJ20654 
                 AB040940 
                 5131 
                 −0.21966498 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ20654 
               
               
                 HSAC005138 
                 KIAA0303 
                 AB002301 
                 54985 
                 −0.27897249 
                 KIAA0303 protein 
               
               
                 KLK7_HUMAN 
                 KLK7 
                 NM_005046 
                 151254 
                 −0.27760264 
                 Kallikrein 7 
               
               
                   
                   
                   
                   
                   
                 (chymotryptic, stratum 
               
               
                   
                   
                   
                   
                   
                 corneum) 
               
               
                 ITP1_HUMAN 
                 ICAP-1A 
                 NM_004763 
                 173274 
                 0.24572607 
                 Integrin cytoplasmic 
               
               
                   
                   
                   
                   
                   
                 domain-associated 
               
               
                   
                   
                   
                   
                   
                 protein 1 
               
               
                 CT26_HUMAN 
                 C20orf26 
                 AL117439 
                 302122 
                 −0.30839956 
                 Chromosome 20 open 
               
               
                   
                   
                   
                   
                   
                 reading frame 26 
               
               
                 MK06_HUMAN 
                 MAPK6 
                 NM_002748 
                 271980 
                 −0.26984777 
                 Mitogen-activated 
               
               
                   
                   
                   
                   
                   
                 protein kinase 6 
               
               
                 HSAC004393 
                 0 
                 AF144233 
                 37372 
                 −0.26241142 
                   Homo sapiens  DNA 
               
               
                   
                   
                   
                   
                   
                 binding peptide mRNA, 
               
               
                   
                   
                   
                   
                   
                 partial cds 
               
               
                 UBC3_HUMAN 
                 CDC34 
                 NM_004359 
                 76932 
                 0.25377891 
                 Cell division cycle 34 
               
               
                 HSAC014234 
                 0 
                 AK056507 
                 183953 
                 −0.24069092 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ31945 fis, clone 
               
               
                   
                   
                   
                   
                   
                 NT2RP7006980 
               
               
                 BRAF_HUMAN 
                 BRAF 
                 NM_004333 
                 622 
                 0.23815317 
                 V-raf murine sarcoma 
               
               
                   
                   
                   
                   
                   
                 viral oncogene 
               
               
                   
                   
                   
                   
                   
                 homolog B1 
               
               
                 HSAC019969 
                 COE2 
                 AK001144 
                 343814 
                 0.23670517 
                 Similar to 
               
               
                   
                   
                   
                   
                   
                 TRANSCRIPTION 
               
               
                   
                   
                   
                   
                   
                 FACTOR COE2 
               
               
                   
                   
                   
                   
                   
                 (EARLY B-CELL 
               
               
                   
                   
                   
                   
                   
                 FACTOR 2) (EBF-2) 
               
               
                   
                   
                   
                   
                   
                 (OLF-1/EBF-LIKE 3) 
               
               
                   
                   
                   
                   
                   
                 (OE-3) (O/E- 
               
               
                 HSAC019505 
                 0 
                 AY039026 
                 334395 
                 −0.18416075 
                 Homo sapiens 
               
               
                   
                   
                   
                   
                   
                 immunoglobulin mu 
               
               
                   
                   
                   
                   
                   
                 chain antibody MO30 
               
               
                   
                   
                   
                   
                   
                 (IgM) mRNA, complete 
               
               
                   
                   
                   
                   
                   
                 cds 
               
               
                 EMP1_HUMAN 
                 EMP1 
                 NM_001423 
                 79368 
                 −0.30522881 
                 Epithelial membrane 
               
               
                   
                   
                   
                   
                   
                 protein 1 
               
               
                 Q9NRI6 
                 PYY2 
                 NM_021093 
                 157195 
                 −0.28539523 
                 Peptide YY, 2 
               
               
                   
                   
                   
                   
                   
                 (seminalplasmin) 
               
               
                 HSAC008290 
                 MGC5618 
                 BC016015 
                 177781 
                 0.28148678 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 MGC5618 
               
               
                 O94927 
                 KIAA0841 
                 AB020648 
                 7426 
                 −0.2681492 
                 KIAA0841 protein 
               
               
                 PRL1_HUMAN 
                 PROL1 
                 NM_021225 
                 87198 
                 −0.26726353 
                 Proline-rich 1 
               
               
                 Q9NWQ8 
                 PAG 
                 NM_018440 
                 266175 
                 0.26596376 
                 Phosphoprotein 
               
               
                   
                   
                   
                   
                   
                 associated with 
               
               
                   
                   
                   
                   
                   
                 glycosphingolipid- 
               
               
                   
                   
                   
                   
                   
                 enriched microdomains 
               
               
                 HSAC009739 
                 0 
                 AK021991 
                 296675 
                 0.26376015 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ11929 fis, clone 
               
               
                   
                   
                   
                   
                   
                 HEMBB1000434 
               
               
                 TAP4_HUMAN 
                 TFAP4 
                 NM_003223 
                 3005 
                 −0.24676795 
                 Transcription factor 
               
               
                   
                   
                   
                   
                   
                 AP-4 (activating 
               
               
                   
                   
                   
                   
                   
                 enhancer binding 
               
               
                   
                   
                   
                   
                   
                 protein 4) 
               
               
                 CSR3_HUMAN 
                 CSRP3 
                 NM_003476 
                 83577 
                 0.22957104 
                 Cysteine and glycine- 
               
               
                   
                   
                   
                   
                   
                 rich protein 3 (cardiac 
               
               
                   
                   
                   
                   
                   
                 LIM protein) 
               
               
                 MYH7_HUMAN 
                 MYH7 
                 NM_000257 
                 929 
                 0.22417182 
                 Myosin, heavy 
               
               
                   
                   
                   
                   
                   
                 polypeptide 7, cardiac 
               
               
                   
                   
                   
                   
                   
                 muscle, beta 
               
               
                 Q13513 
                 HSU47926 
                 NM_014262 
                 46458 
                 0.2822699 
                 Hypothetical protein B 
               
               
                 CU97_HUMAN 
                 FLJ21324 
                 AL161960 
                 4746 
                 −0.27189524 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ21324 
               
               
                 Q96EL2 
                 MRPS24 
                 NM_032014 
                 284286 
                 0.26906488 
                 Mitochondrial 
               
               
                   
                   
                   
                   
                   
                 ribosomal protein S24 
               
               
                 PYR1_HUMAN 
                 CAD 
                 NM_004341 
                 154868 
                 0.26618776 
                 Carbamoyl-phosphate 
               
               
                   
                   
                   
                   
                   
                 synthetase 2, aspartate 
               
               
                   
                   
                   
                   
                   
                 transcarbamylase, and 
               
               
                   
                   
                   
                   
                   
                 dihydroorotase 
               
               
                 SPS2_HUMAN 
                 SPS2 
                 NM_012248 
                 118725 
                 0.23578101 
                 Selenophosphate 
               
               
                   
                   
                   
                   
                   
                 synthetase 2 
               
               
                 HSAC005553 
                 KIAA0483 
                 AB007952 
                 64691 
                 −0.23107771 
                 KIAA0483 protein 
               
               
                 Q8NC10 
                 FLJ20258 
                 NM_017729 
                 28907 
                 −0.29044408 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ20258 
               
               
                 HSAC007558 
                 0 
                 AK024653 
                 163440 
                 −0.28942837 
                   Homo sapiens  cDNA: 
               
               
                   
                   
                   
                   
                   
                 FLJ21000 fis, clone 
               
               
                   
                   
                   
                   
                   
                 CAE03359 
               
               
                 Q96HT2 
                 0 
                 BC008122 
                 334931 
                 −0.28388928 
                   Homo sapiens , clone 
               
               
                   
                   
                   
                   
                   
                 MGC: 18053 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 4148889, 
               
               
                   
                   
                   
                   
                   
                 mRNA, complete cds 
               
               
                 P02570 
                 ACTB 
                 NM_001101 
                 288061 
                 0.28095417 
                 Actin, beta 
               
               
                 Q96HG1 
                 0 
                 BC008642 
                 42239 
                 −0.26271036 
                   Homo sapiens , clone 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 3868989, 
               
               
                   
                   
                   
                   
                   
                 mRNA, partial cds 
               
               
                 Q9H5C5 
                 FLJ23584 
                 NM_024588 
                 22195 
                 −0.25933423 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ23584 
               
               
                 HSAC014930 
                 0 
                 AK022228 
                 202577 
                 −0.25403533 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ12166 fis, clone 
               
               
                   
                   
                   
                   
                   
                 MAMMA1000616 
               
               
                 Q8ND68 
                 PLVAP 
                 NM_031310 
                 107125 
                 0.24973622 
                 Plasmalemma vesicle 
               
               
                   
                   
                   
                   
                   
                 associated protein 
               
               
                 Q9NPW0 
                 DKFZp547M236 
                 NM_018713 
                 20981 
                 −0.24604121 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 DKFZp547M236 
               
               
                 HSAC001572 
                 0 
                 AK055659 
                 8037 
                 0.24451604 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ31097 fis, clone 
               
               
                   
                   
                   
                   
                   
                 IMR321000210 
               
               
                 PARB_HUMAN 
                 PARVB 
                 NM_013327 
                 8836 
                 −0.2429299 
                 Parvin beta 
               
               
                 HSAC009747 
                 0 
                 AK022065 
                 296683 
                 −0.23257064 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ12003 fis, clone 
               
               
                   
                   
                   
                   
                   
                 HEMBB1001537 
               
               
                 RL3_HUMAN 
                 RPL3 
                 BC011860 
                 119598 
                 0.22612107 
                 Ribosomal protein L3 
               
               
                 CA1B_HUMAN 
                 COL11A1 
                 NM_001854 
                 82772 
                 0.22373492 
                 Collagen, type XI, 
               
               
                   
                   
                   
                   
                   
                 alpha 1 
               
               
                 STAT_HUMAN 
                 STATH 
                 NM_003154 
                 37048 
                 −0.18441286 
                 Statherin 
               
               
                 HSAC015960 
                 0 
                 AF153502 
                 247887 
                 0.27007396 
                   Homo sapiens  SNAI1P 
               
               
                   
                   
                   
                   
                   
                 pseudogene 
               
               
                 T1L1_HUMAN 
                 TOM1L1 
                 NM_005486 
                 153504 
                 −0.25974431 
                 Target of myb1-like 1 
               
               
                   
                   
                   
                   
                   
                 (chicken) 
               
               
                 Q8WV53 
                 DKFZP564A2416 
                 NM_015535 
                 5297 
                 0.25296148 
                 DKFZP564A2416 
               
               
                   
                   
                   
                   
                   
                 protein 
               
               
                 HS9A_HUMAN 
                 HSPCA 
                 AK056446 
                 289088 
                 0.25051774 
                 Heat shock 90 kD 
               
               
                   
                   
                   
                   
                   
                 protein 1, alpha 
               
               
                 BM88_HUMAN 
                 BM88 
                 NM_016564 
                 22140 
                 −0.24739798 
                 BM88 antigen 
               
               
                 HSAC021209 
                 0 
                 AK021479 
                 351685 
                 −0.24183743 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ11417 fis, clone 
               
               
                   
                   
                   
                   
                   
                 HEMBA1000960 
               
               
                 TIG2_HUMAN 
                 RARRES2 
                 NM_002889 
                 37682 
                 0.24052315 
                 Retinoic acid receptor 
               
               
                   
                   
                   
                   
                   
                 responder (tazarotene 
               
               
                   
                   
                   
                   
                   
                 induced) 2 
               
               
                 ABC3_HUMAN 
                 ABCA3 
                 NM_001089 
                 26630 
                 −0.23736913 
                 ATP-binding cassette, 
               
               
                   
                   
                   
                   
                   
                 sub-family A (ABC1), 
               
               
                   
                   
                   
                   
                   
                 member 3 
               
               
                 Q96SG6 
                 0 
                 BC014899 
                 72087 
                 −0.23557118 
                   Homo sapiens , clone 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 3912307, 
               
               
                   
                   
                   
                   
                   
                 mRNA 
               
               
                 COP1_HUMAN 
                 0 
                 AK056926 
                 350222 
                 0.23440455 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ32364 fis, clone 
               
               
                   
                   
                   
                   
                   
                 PUAEN1000147 
               
               
                 HSAC005034 
                 0 
                 AF070602 
                 51649 
                 −0.22614962 
                   Homo sapiens  clone 
               
               
                   
                   
                   
                   
                   
                 24504 mRNA 
               
               
                   
                   
                   
                   
                   
                 sequence 
               
               
                 Q9BV20 
                 MGC3207 
                 AK026666 
                 13075 
                 0.21874807 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 MGC3207 
               
               
                 IL8_HUMAN 
                 IL8 
                 NM_000584 
                 624 
                 0.21295363 
                 Interleukin 8 
               
               
                 TGM3_HUMAN 
                 TGM3 
                 NM_003245 
                 2022 
                 −0.30559572 
                 Transglutaminase 3 (E 
               
               
                   
                   
                   
                   
                   
                 polypeptide, protein- 
               
               
                   
                   
                   
                   
                   
                 glutamine-gamma- 
               
               
                   
                   
                   
                   
                   
                 glutamyltransferase) 
               
               
                 FILA_HUMAN 
                 0 
                 BE551792 
                 251440 
                 −0.2882993 
                 EST, Highly similar to 
               
               
                   
                   
                   
                   
                   
                 A48118 major 
               
               
                   
                   
                   
                   
                   
                 epidermal calcium- 
               
               
                   
                   
                   
                   
                   
                 binding protein 
               
               
                   
                   
                   
                   
                   
                 profilaggrin [ H. sapiens ] 
               
               
                 Q96DP9 
                 0 
                 AK055428 
                 351007 
                 −0.28316024 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ30866 fis, clone 
               
               
                   
                   
                   
                   
                   
                 FEBRA2004110, highly 
               
               
                   
                   
                   
                   
                   
                 similar to 
               
               
                   
                   
                   
                   
                   
                 PHOSPHOLIPASE 
               
               
                   
                   
                   
                   
                   
                 ADRAB-B PRECURSO 
               
               
                 Q9C0G8 
                 KIAA1695 
                 AB051482 
                 288841 
                 0.27341074 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ22297 
               
               
                 PPIG_HUMAN 
                 PPIG 
                 NM_004792 
                 77965 
                 −0.26853004 
                 Peptidyl-prolyl 
               
               
                   
                   
                   
                   
                   
                 isomerase G 
               
               
                   
                   
                   
                   
                   
                 (cyclophilin G) 
               
               
                 ANX1_HUMAN 
                 ANXA1 
                 NM_000700 
                 78225 
                 −0.26467494 
                 Annexin A1 
               
               
                 Q9H8H3 
                 DKFZP586A0522 
                 NM_014033 
                 288771 
                 −0.26179709 
                 DKFZP586A0522 
               
               
                   
                   
                   
                   
                   
                 protein 
               
               
                 ENOA_HUMAN 
                 ENO1 
                 NM_001428 
                 254105 
                 0.25723939 
                 Enolase 1, (alpha) 
               
               
                 SOX5_HUMAN 
                 SOX5 
                 NM_006940 
                 87224 
                 −0.25633005 
                 SRY (sex determining 
               
               
                   
                   
                   
                   
                   
                 region Y)-box 5 
               
               
                 MSX1_HUMAN 
                 MSX1 
                 NM_002448 
                 1494 
                 0.2563254 
                 Msh homeo box 
               
               
                   
                   
                   
                   
                   
                 homolog 1 ( Drosophila ) 
               
               
                 HSAC019559 
                 0 
                 AK021983 
                 334535 
                 −0.25479699 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ11921 fis, clone 
               
               
                   
                   
                   
                   
                   
                 HEMBB1000318 
               
               
                 HSAC016142 
                 0 
                 X76785 
                 249131 
                 0.24660385 
                   H. sapiens  genomic 
               
               
                   
                   
                   
                   
                   
                 DNA, integration site 
               
               
                   
                   
                   
                   
                   
                 for Epstein-Barr virus 
               
               
                 Q9HBZ7 
                 FLJ11305 
                 AK024478 
                 7049 
                 0.24408926 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ11305 
               
               
                 CMST_HUMAN 
                 SLC35A1 
                 NM_006416 
                 82921 
                 −0.23742472 
                 Solute carrier family 35 
               
               
                   
                   
                   
                   
                   
                 (CMP-sialic acid 
               
               
                   
                   
                   
                   
                   
                 transporter), member 1 
               
               
                 SIM1_HUMAN 
                 SIM1 
                 NM_005068 
                 105925 
                 −0.23141341 
                 Single-minded 
               
               
                   
                   
                   
                   
                   
                 homolog 1 ( Drosophila ) 
               
               
                 Q8IXU2 
                 FLJ20190 
                 NM_017705 
                 257511 
                 0.21886983 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ20190 
               
               
                 C166_HUMAN 
                 ALCAM 
                 Y10183 
                 10247 
                 0.19097406 
                 Activated leucocyte cell 
               
               
                   
                   
                   
                   
                   
                 adhesion molecule 
               
               
                 Q96AP0 
                 24432 
                 NM_022914 
                 78019 
                 0.1866136 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 24432 
               
               
                 HSAC018926 
                 0 
                 AK000989 
                 319540 
                 −0.1726173 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ10127 fis, clone 
               
               
                   
                   
                   
                   
                   
                 HEMBA1002973, 
               
               
                   
                   
                   
                   
                   
                 moderately similar to 
               
               
                   
                   
                   
                   
                   
                 CAMP-DEPENDENT 
               
               
                   
                   
                   
                   
                   
                 3′,5′-CYCLI 
               
               
                 HSAC019510 
                 H2AFKP 
                 Z80777 
                 334456 
                 −0.2885027 
                 H2A histone family, 
               
               
                   
                   
                   
                   
                   
                 member K, 
               
               
                   
                   
                   
                   
                   
                 pseudogene 
               
               
                 HSAC021283 
                 0 
                 BC018033 
                 351860 
                 −0.27842193 
                   Homo sapiens , clone 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 4800052, 
               
               
                   
                   
                   
                   
                   
                 mRNA, partial cds 
               
               
                 Q9NQ25 
                 CRACC 
                 AB027233 
                 132906 
                 −0.25159742 
                 19A24 protein 
               
               
                 MGP_HUMAN 
                 MGP 
                 NM_000900 
                 279009 
                 0.25075401 
                 Matrix Gla protein 
               
               
                 HSAC018514 
                 0 
                 AK024924 
                 306729 
                 −0.24315744 
                   Homo sapiens  cDNA: 
               
               
                   
                   
                   
                   
                   
                 FLJ21271 fis, clone 
               
               
                   
                   
                   
                   
                   
                 COL01751 
               
               
                 ABC6_HUMAN 
                 ABCB6 
                 NM_005689 
                 107911 
                 0.24312557 
                 ATP-binding cassette, 
               
               
                   
                   
                   
                   
                   
                 sub-family B 
               
               
                   
                   
                   
                   
                   
                 (MDR/TAP), member 6 
               
               
                 HSAC016919 
                 HEP27 
                 NM_005794 
                 272499 
                 0.23808329 
                 Short-chain alcohol 
               
               
                   
                   
                   
                   
                   
                 dehydrogenase family 
               
               
                   
                   
                   
                   
                   
                 member 
               
               
                 CD45_HUMAN 
                 PTPRC 
                 NM_002838 
                 170121 
                 −0.23455219 
                 Protein tyrosine 
               
               
                   
                   
                   
                   
                   
                 phosphatase, receptor 
               
               
                   
                   
                   
                   
                   
                 type, C 
               
               
                 Q9ULT2 
                 KIAA1138 
                 AB032964 
                 115726 
                 −0.22789488 
                 KIAA1138 protein 
               
               
                 SY3L_HUMAN 
                 SCYA3 
                 NM_002983 
                 73817 
                 0.22252932 
                 Small inducible 
               
               
                   
                   
                   
                   
                   
                 cytokine A3 
               
               
                 MM26_HUMAN 
                 MMP26 
                 NM_021801 
                 204732 
                 0.18951291 
                 Matrix 
               
               
                   
                   
                   
                   
                   
                 metalloproteinase 26 
               
               
                 PRL4_HUMAN 
                 PROL4 
                 NM_007244 
                 45033 
                 −0.01191859 
                 Proline rich 4 (lacrimal) 
               
               
                 P78545 
                 ELF3 
                 NM_004433 
                 166096 
                 −0.29828398 
                 E74-like factor 3 (ets 
               
               
                   
                   
                   
                   
                   
                 domain transcription 
               
               
                   
                   
                   
                   
                   
                 factor, epithelial- 
               
               
                   
                   
                   
                   
                   
                 specific) 
               
               
                 NIC1_HUMAN 
                 NICE-1 
                 NM_019060 
                 110196 
                 −0.2971944 
                 NICE-1 protein 
               
               
                 CLD7_HUMAN 
                 CLDN7 
                 NM_001307 
                 278562 
                 −0.28206037 
                 Claudin 7 
               
               
                 KLKA_HUMAN 
                 0 
                 AK026045 
                 275464 
                 −0.28180039 
                   Homo sapiens  cDNA: 
               
               
                   
                   
                   
                   
                   
                 FLJ22392 fis, clone 
               
               
                   
                   
                   
                   
                   
                 HRC07868 
               
               
                 Q9P0A7 
                 C20orf30 
                 NM_014145 
                 3576 
                 0.27874372 
                 Chromosome 20 open 
               
               
                   
                   
                   
                   
                   
                 reading frame 30 
               
               
                 HSAC019283 
                 0 
                 AK026112 
                 330418 
                 −0.27010085 
                   Homo sapiens  cDNA: 
               
               
                   
                   
                   
                   
                   
                 FLJ22459 fis, clone 
               
               
                   
                   
                   
                   
                   
                 HRC10045 
               
               
                 Q9NYJ6 
                 LOC51328 
                 NM_016637 
                 272413 
                 −0.2695095 
                 Ncaml 
               
               
                 Q96HJ4 
                 NUF2R 
                 NM_031423 
                 234545 
                 −0.2663022 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 NUF2R 
               
               
                 PAB4_HUMAN 
                 PABPC4 
                 NM_003819 
                 169900 
                 0.25652471 
                 Poly(A) binding protein, 
               
               
                   
                   
                   
                   
                   
                 cytoplasmic 4 
               
               
                   
                   
                   
                   
                   
                 (inducible form) 
               
               
                 HSAC012638 
                 FLJ12994 
                 NM_022841 
                 126908 
                 −0.25215608 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ12994 
               
               
                 HS47_HUMAN 
                 SERPINH2 
                 NM_001235 
                 9930 
                 0.2460832 
                 Serine (or cysteine) 
               
               
                   
                   
                   
                   
                   
                 proteinase inhibitor, 
               
               
                   
                   
                   
                   
                   
                 clade H (heat shock 
               
               
                   
                   
                   
                   
                   
                 protein 47), member 2 
               
               
                 Q9ULL9 
                 KIAA1201 
                 AB033027 
                 251278 
                 −0.24435799 
                 KIAA1201 protein 
               
               
                 TYY1_HUMAN 
                 YY1 
                 NM_003403 
                 97496 
                 0.23844943 
                 YY1 transcription factor 
               
               
                 HSAC016540 
                 ENPP3 
                 NM_005021 
                 264750 
                 0.23341437 
                 Ectonucleotide 
               
               
                   
                   
                   
                   
                   
                 pyrophosphatase/phosphodiesterase 3 
               
               
                 IP3K_HUMAN 
                 ITPKA 
                 NM_002220 
                 2722 
                 0.231694 
                 Inositol 1,4,5- 
               
               
                   
                   
                   
                   
                   
                 trisphosphate 3-kinase A 
               
               
                 HSAC009930 
                 MGC17528 
                 BC010541 
                 300893 
                 −0.23039734 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 MGC17528 
               
               
                 CRE3_HUMAN 
                 CREB3 
                 NM_006368 
                 287921 
                 0.22584512 
                 CAMP responsive 
               
               
                   
                   
                   
                   
                   
                 element binding protein 
               
               
                   
                   
                   
                   
                   
                 3 (luman) 
               
               
                 HSAC016682 
                 0 
                 AK057367 
                 270002 
                 −0.22515872 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ32805 fis, clone 
               
               
                   
                   
                   
                   
                   
                 TESTI2002690 
               
               
                 TFE2_HUMAN 
                 TCF3 
                 M31523 
                 101047 
                 0.21777199 
                 Transcription factor 3 
               
               
                   
                   
                   
                   
                   
                 (E2A immunoglobulin 
               
               
                   
                   
                   
                   
                   
                 enhancer binding 
               
               
                   
                   
                   
                   
                   
                 factors E12/E47) 
               
               
                 BIN1_HUMAN 
                 BIN1 
                 NM_004305 
                 193163 
                 0.2155171 
                 Bridging integrator 1 
               
               
                 HSAC012959 
                 0 
                 AK023520 
                 131798 
                 −0.21368949 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ13458 fis, clone 
               
               
                   
                   
                   
                   
                   
                 PLACE1003361 
               
               
                 Q64320 
                 STXBP1 
                 NM_003165 
                 239356 
                 −0.19357344 
                 Syntaxin binding 
               
               
                   
                   
                   
                   
                   
                 protein 1 
               
               
                 3BH1_HUMAN 
                 HSD3B1 
                 NM_000862 
                 38586 
                 −0.19079495 
                 Hydroxy-delta-5-steroid 
               
               
                   
                   
                   
                   
                   
                 dehydrogenase, 3 
               
               
                   
                   
                   
                   
                   
                 beta- and steroid delta- 
               
               
                   
                   
                   
                   
                   
                 isomerase 1 
               
               
                 P04270 
                 ACTA1 
                 NM_001100 
                 1288 
                 0.17079596 
                 Actin, alpha 1, skeletal 
               
               
                   
                   
                   
                   
                   
                 muscle 
               
               
                 GLPB_HUMAN 
                 GYPA 
                 NM_002099 
                 108694 
                 −0.2797532 
                 Glycophorin A 
               
               
                   
                   
                   
                   
                   
                 (includes MN blood 
               
               
                   
                   
                   
                   
                   
                 group) 
               
               
                 TIG3_HUMAN 
                 RARRES3 
                 NM_004585 
                 17466 
                 −0.26355336 
                 Retinoic acid receptor 
               
               
                   
                   
                   
                   
                   
                 responder (tazarotene 
               
               
                   
                   
                   
                   
                   
                 induced) 3 
               
               
                 Q9HAE0 
                 FLJ11783 
                 NM_024891 
                 232167 
                 −0.26191261 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ11783 
               
               
                 OFU1_HUMAN 
                 POFUT1 
                 AF375884 
                 178292 
                 0.25365544 
                 Protein O- 
               
               
                   
                   
                   
                   
                   
                 fucosyltransferase 1 
               
               
                 HSAC009500 
                 MMPL1 
                 NM_004142 
                 290222 
                 −0.25346089 
                 Matrix 
               
               
                   
                   
                   
                   
                   
                 metalloproteinase-like 1 
               
               
                 COXK_HUMAN 
                 COX7A1 
                 NM_001864 
                 114346 
                 0.25190367 
                 Cytochrome c oxidase 
               
               
                   
                   
                   
                   
                   
                 subunit VIIa 
               
               
                   
                   
                   
                   
                   
                 polypeptide 1 (muscle) 
               
               
                 BTE1_HUMAN 
                 BTEB1 
                 NM_001206 
                 150557 
                 0.24546012 
                 Basic transcription 
               
               
                   
                   
                   
                   
                   
                 element binding protein 
               
               
                 OPSD_HUMAN 
                 RHO 
                 NM_000539 
                 247565 
                 0.24293319 
                 Rhodopsin (opsin 2, 
               
               
                   
                   
                   
                   
                   
                 rod pigment) (retinitis 
               
               
                   
                   
                   
                   
                   
                 pigmentosa 4, 
               
               
                   
                   
                   
                   
                   
                 autosomal dominant) 
               
               
                 PLCB_HUMAN 
                 AGPAT2 
                 NM_006412 
                 209119 
                 0.24123053 
                 1-acylglycerol-3- 
               
               
                   
                   
                   
                   
                   
                 phosphate O- 
               
               
                   
                   
                   
                   
                   
                 acyltransferase 2 
               
               
                   
                   
                   
                   
                   
                 (lysophosphatidic acid 
               
               
                   
                   
                   
                   
                   
                 acyltransferase, beta) 
               
               
                 Q15668 
                 NPC2 
                 NM_006432 
                 119529 
                 0.22752332 
                 Niemann-Pick disease, 
               
               
                   
                   
                   
                   
                   
                 type C2 
               
               
                 Q9UBI4 
                 STOML1 
                 NM_004809 
                 194816 
                 0.21956228 
                 Stomatin (EBP72)-like 1 
               
               
                 AAP04413 
                 0 
                 AL133654 
                 201603 
                 0.21881691 
                   Homo sapiens  mRNA; 
               
               
                   
                   
                   
                   
                   
                 cDNA 
               
               
                   
                   
                   
                   
                   
                 DKFZp434D0917 (from 
               
               
                   
                   
                   
                   
                   
                 clone 
               
               
                   
                   
                   
                   
                   
                 DKFZp434D0917) 
               
               
                 Q8WWF8 
                 0 
                 BC017586 
                 55150 
                 −0.19756688 
                   Homo sapiens , Similar 
               
               
                   
                   
                   
                   
                   
                 to RIKEN cDNA 
               
               
                   
                   
                   
                   
                   
                 1700028N11 gene, 
               
               
                   
                   
                   
                   
                   
                 clone MGC: 26610 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 4837506, 
               
               
                   
                   
                   
                   
                   
                 mRNA, complete c 
               
               
                 HSAC018492 
                 0 
                 AK024800 
                 306704 
                 −0.28750526 
                   Homo sapiens  cDNA: 
               
               
                   
                   
                   
                   
                   
                 FLJ21147 fis, clone 
               
               
                   
                   
                   
                   
                   
                 CAS09371 
               
               
                 Q9C0D8 
                 0 
                 BC008941 
                 207024 
                 −0.28684225 
                   Homo sapiens , Similar 
               
               
                   
                   
                   
                   
                   
                 to hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ20515, clone 
               
               
                   
                   
                   
                   
                   
                 MGC: 2696 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 2820596, 
               
               
                   
                   
                   
                   
                   
                 mRNA, complete 
               
               
                 DDC_HUMAN 
                 DDC 
                 NM_000790 
                 150403 
                 −0.2843375 
                 Dopa decarboxylase 
               
               
                   
                   
                   
                   
                   
                 (aromatic L-amino acid 
               
               
                   
                   
                   
                   
                   
                 decarboxylase) 
               
               
                 FBW4_HUMAN 
                 SHFM3 
                 AK056917 
                 24307 
                 0.28026937 
                 Split hand/foot 
               
               
                   
                   
                   
                   
                   
                 malformation 
               
               
                   
                   
                   
                   
                   
                 (ectrodactyly) type 3 
               
               
                 QCAA000051 
                 0 
                 0 
                 0 
                 −0.26836294 
                 Randomized negative 
               
               
                   
                   
                   
                   
                   
                 control 
               
               
                 Q9UM77 
                 OR1E3P 
                 U53583 
                 248182 
                 −0.2620377 
                 Olfactory receptor, 
               
               
                   
                   
                   
                   
                   
                 family 1, subfamily E, 
               
               
                   
                   
                   
                   
                   
                 member 3 pseudogene 
               
               
                 TYBP_HUMAN 
                 TYROBP 
                 NM_003332 
                 9963 
                 −0.25688511 
                 TYRO protein tyrosine 
               
               
                   
                   
                   
                   
                   
                 kinase binding protein 
               
               
                 SCP1_HUMAN 
                 SYCP1 
                 NM_003176 
                 112743 
                 −0.25216102 
                 Synaptonemal complex 
               
               
                   
                   
                   
                   
                   
                 protein 1 
               
               
                 Q9HCH7 
                 KIAA1595 
                 AB046815 
                 286173 
                 0.25125685 
                 KIAA1595 protein 
               
               
                 HSAC012142 
                 ERH 
                 NM_004450 
                 118757 
                 0.24637661 
                 Enhancer of 
               
               
                   
                   
                   
                   
                   
                 rudimentary homolog 
               
               
                   
                   
                   
                   
                   
                 ( Drosophila ) 
               
               
                 ACLY_HUMAN 
                 ACLY 
                 NM_001096 
                 174140 
                 0.24619185 
                 ATP citrate lyase 
               
               
                 S3B2_HUMAN 
                 SF3B2 
                 NM_006842 
                 75916 
                 0.24414637 
                 Splicing factor 3b, 
               
               
                   
                   
                   
                   
                   
                 subunit 2, 145 kD 
               
               
                 O14731 
                 PKMYT1 
                 NM_004203 
                 77783 
                 0.24202938 
                 Membrane-associated 
               
               
                   
                   
                   
                   
                   
                 tyrosine- and 
               
               
                   
                   
                   
                   
                   
                 threonine-specific 
               
               
                   
                   
                   
                   
                   
                 cdc2-inhibitory kinase 
               
               
                 HSAC003854 
                 0 
                 AK025794 
                 28631 
                 −0.24081021 
                   Homo sapiens  cDNA: 
               
               
                   
                   
                   
                   
                   
                 FLJ22141 fis, clone 
               
               
                   
                   
                   
                   
                   
                 HEP21327 
               
               
                 HSAC020709 
                 0 
                 AK057203 
                 350710 
                 −0.23982763 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ32641 fis, clone 
               
               
                   
                   
                   
                   
                   
                 SYNOV2001035 
               
               
                 UNRI_HUMAN 
                 UNRIP 
                 NM_007178 
                 3727 
                 0.23894091 
                 Unr-interacting protein 
               
               
                 PGTA_HUMAN 
                 RABGGTA 
                 NM_004581 
                 78920 
                 −0.23645356 
                 Rab 
               
               
                   
                   
                   
                   
                   
                 geranylgeranyltransferase, 
               
               
                   
                   
                   
                   
                   
                 alpha subunit 
               
               
                 HSAC019191 
                 0 
                 AL080233 
                 326580 
                 −0.23022427 
                   Homo sapiens  mRNA; 
               
               
                   
                   
                   
                   
                   
                 cDNA DKFZp586L111 
               
               
                   
                   
                   
                   
                   
                 (from clone 
               
               
                   
                   
                   
                   
                   
                 DKFZp586L111) 
               
               
                 SDB2_HUMAN 
                 SDCBP2 
                 NM_015685 
                 64179 
                 −0.22859025 
                 Syndecan binding 
               
               
                   
                   
                   
                   
                   
                 protein (syntenin) 2 
               
               
                 CTC9_HUMAN 
                 C20orf129 
                 AK055793 
                 70704 
                 −0.22775703 
                 Chromosome 20 open 
               
               
                   
                   
                   
                   
                   
                 reading frame 129 
               
               
                 PCN2_HUMAN 
                 PCNT2 
                 NM_006031 
                 15896 
                 −0.22667113 
                 Pericentrin 2 (kendrin) 
               
               
                 IF42_HUMAN 
                 EIF4A2 
                 NM_001967 
                 173912 
                 0.22657769 
                 Eukaryotic translation 
               
               
                   
                   
                   
                   
                   
                 initiation factor 4A, 
               
               
                   
                   
                   
                   
                   
                 isoform 2 
               
               
                 HSAC018456 
                 0 
                 AK024123 
                 306664 
                 −0.22504349 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ14061 fis, clone 
               
               
                   
                   
                   
                   
                   
                 HEMBB1000749 
               
               
                 HSAC018632 
                 0 
                 AK026722 
                 306870 
                 0.22009923 
                   Homo sapiens  cDNA: 
               
               
                   
                   
                   
                   
                   
                 FLJ23069 fis, clone 
               
               
                   
                   
                   
                   
                   
                 LNG05603 
               
               
                 ATS1_HUMAN 
                 ADAMTS1 
                 NM_006988 
                 8230 
                 0.20713748 
                 A disintegrin-like and 
               
               
                   
                   
                   
                   
                   
                 metalloprotease 
               
               
                   
                   
                   
                   
                   
                 (reprolysin type) with 
               
               
                   
                   
                   
                   
                   
                 thrombospondin type 1 
               
               
                   
                   
                   
                   
                   
                 motif, 1 
               
               
                 Q96DP3 
                 WAC 
                 AB058747 
                 70333 
                 0.20422375 
                 WW domain-containing 
               
               
                   
                   
                   
                   
                   
                 adapter with a coiled- 
               
               
                   
                   
                   
                   
                   
                 coil region 
               
               
                 HSAC002790 
                 DKFZp667O2416 
                 AK056427 
                 19066 
                 −0.19264477 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 DKFZp667O2416 
               
               
                 AN11_HUMAN 
                 ANAPC11 
                 NM_016476 
                 183180 
                 0.18856896 
                 APC11 anaphase 
               
               
                   
                   
                   
                   
                   
                 promoting complex 
               
               
                   
                   
                   
                   
                   
                 subunit 11 homolog 
               
               
                   
                   
                   
                   
                   
                 (yeast) 
               
               
                 Q96M94 
                 KIAA1677 
                 AB051464 
                 61603 
                 0.17363087 
                 KIAA1677 
               
               
                 HSAC017386 
                 HSPC073 
                 NM_014163 
                 278948 
                 0.15730714 
                 HSPC073 protein 
               
               
                 HSAC006154 
                 CD14 
                 NM_000591 
                 75627 
                 0.27102209 
                 CD14 antigen 
               
               
                 PPIF_HUMAN 
                 PPIF 
                 NM_005729 
                 173125 
                 −0.26443857 
                 Peptidylprolyl 
               
               
                   
                   
                   
                   
                   
                 isomerase F 
               
               
                   
                   
                   
                   
                   
                 (cyclophilin F) 
               
               
                 Q9NT21 
                 0 
                 AL137581 
                 112589 
                 −0.26076922 
                   Homo sapiens  mRNA; 
               
               
                   
                   
                   
                   
                   
                 cDNA 
               
               
                   
                   
                   
                   
                   
                 DKFZp434B0610 (from 
               
               
                   
                   
                   
                   
                   
                 clone 
               
               
                   
                   
                   
                   
                   
                 DKFZp434B0610); 
               
               
                   
                   
                   
                   
                   
                 partial cds 
               
               
                 Q9H6B9 
                 FLJ22408 
                 NM_024794 
                 156457 
                 −0.25752275 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ22408 
               
               
                 LDHA_HUMAN 
                 LDHA 
                 NM_005566 
                 2795 
                 0.25289918 
                 Lactate dehydrogenase A 
               
               
                 H2AY_HUMAN 
                 H2AFY 
                 NM_004893 
                 75258 
                 −0.2518442 
                 H2A histone family, 
               
               
                   
                   
                   
                   
                   
                 member Y 
               
               
                 HSAC009983 
                 0 
                 AK022320 
                 301232 
                 −0.2470859 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ12258 fis, clone 
               
               
                   
                   
                   
                   
                   
                 MAMMA1001510 
               
               
                 HSAC014390 
                 0 
                 AK001865 
                 188228 
                 0.24557304 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ11003 fis, clone 
               
               
                   
                   
                   
                   
                   
                 PLACE1002851 
               
               
                 GT4R_HUMAN 
                 SLC2A4RG 
                 NM_020062 
                 170088 
                 0.24473836 
                 SLC2A4 regulator 
               
               
                 FOS_HUMAN 
                 FOS 
                 NM_005252 
                 25647 
                 −0.24335376 
                 V-fos FBJ murine 
               
               
                   
                   
                   
                   
                   
                 osteosarcoma viral 
               
               
                   
                   
                   
                   
                   
                 oncogene homolog 
               
               
                 Q9BWL3 
                 DKFZP586G1722 
                 NM_015449 
                 31989 
                 0.24290984 
                 DKFZP586G1722 
               
               
                   
                   
                   
                   
                   
                 protein 
               
               
                 CY1_HUMAN 
                 CYC1 
                 NM_001916 
                 289271 
                 0.242676 
                 Cytochrome c-1 
               
               
                 Q8IX90 
                 0 
                 BC013418 
                 88523 
                 0.24027868 
                   Homo sapiens , clone 
               
               
                   
                   
                   
                   
                   
                 MGC: 4832 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 3604003, 
               
               
                   
                   
                   
                   
                   
                 mRNA, complete cds 
               
               
                 GALA_HUMAN 
                 GAL 
                 M77140 
                 1907 
                 0.23487288 
                 Galanin 
               
               
                 P02593 
                 CALM2 
                 AK055130 
                 182278 
                 0.23450179 
                 Calmodulin 2 
               
               
                   
                   
                   
                   
                   
                 (phosphorylase kinase, 
               
               
                   
                   
                   
                   
                   
                 delta) 
               
               
                 HSAC020657 
                 0 
                 AK057533 
                 350657 
                 0.2332272 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ32971 fis, clone 
               
               
                   
                   
                   
                   
                   
                 TESTI2008847 
               
               
                 Q9H125 
                 C20orf118 
                 AL079335 
                 287784 
                 0.22896758 
                 Chromosome 20 open 
               
               
                   
                   
                   
                   
                   
                 reading frame 118 
               
               
                 Q8N8N8 
                 DKFZP434G145 
                 BC007359 
                 31931 
                 0.22106691 
                 DKFZP434G145 
               
               
                   
                   
                   
                   
                   
                 protein 
               
               
                 GBAP_HUMAN 
                 GABARAP 
                 NM_007278 
                 7719 
                 −0.22052485 
                 GABA(A) receptor- 
               
               
                   
                   
                   
                   
                   
                 associated protein 
               
               
                 DYI4_HUMAN 
                 DNAI2 
                 NM_023036 
                 147472 
                 0.2163783 
                 Dynein intermediate 
               
               
                   
                   
                   
                   
                   
                 chain 2 
               
               
                 HSAC017486 
                 HDAC3 
                 AF130111 
                 279789 
                 −0.21279266 
                 Histone deacetylase 3 
               
               
                 NUBM_HUMAN 
                 0 
                 AK055875 
                 324151 
                 0.21264326 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ31313 fis, clone 
               
               
                   
                   
                   
                   
                   
                 LIVER1000230, highly 
               
               
                   
                   
                   
                   
                   
                 similar to NADH- 
               
               
                   
                   
                   
                   
                   
                 UBIQUINONE 
               
               
                   
                   
                   
                   
                   
                 OXIDOREDUCTASE 
               
               
                 NRCA_HUMAN 
                 NRCAM 
                 NM_005010 
                 7912 
                 −0.20902953 
                 Neuronal cell adhesion 
               
               
                   
                   
                   
                   
                   
                 molecule 
               
               
                 IF42_HUMAN 
                 EIF4A2 
                 NM_001967 
                 173912 
                 0.20860474 
                 Eukaryotic translation 
               
               
                   
                   
                   
                   
                   
                 initiation factor 4A, 
               
               
                   
                   
                   
                   
                   
                 isoform 2 
               
               
                 CATB_HUMAN 
                 CTSB 
                 NM_001908 
                 297939 
                 0.20693544 
                 Cathepsin B 
               
               
                 HSAC009142 
                 0 
                 AK026499 
                 287713 
                 −0.20623884 
                   Homo sapiens  cDNA: 
               
               
                   
                   
                   
                   
                   
                 FLJ22752 fis, clone 
               
               
                   
                   
                   
                   
                   
                 KAIA0555 
               
               
                 NGAP_HUMAN 
                 RASAL2 
                 NM_004841 
                 227806 
                 0.18773486 
                 RAS protein activator 
               
               
                   
                   
                   
                   
                   
                 like 2 
               
               
                 H10_HUMAN 
                 H1F0 
                 BC000145 
                 226117 
                 0.18021445 
                 H1 histone family, 
               
               
                   
                   
                   
                   
                   
                 member 0 
               
               
                 RNP_HUMAN 
                 RNASE1 
                 NM_002933 
                 78224 
                 0.17681221 
                 Ribonuclease, RNase 
               
               
                   
                   
                   
                   
                   
                 A family, 1 (pancreatic) 
               
               
                 HSAC021160 
                 0 
                 AK054984 
                 351562 
                 0.13703193 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ30422 fis, clone 
               
               
                   
                   
                   
                   
                   
                 BRACE2008861 
               
               
                 Q9BYE3 
                 LEP16 
                 NM_032563 
                 244349 
                 −0.28446955 
                 Epidermal 
               
               
                   
                   
                   
                   
                   
                 differentiation complex 
               
               
                   
                   
                   
                   
                   
                 protein like protein 
               
               
                 O75042 
                 0 
                 AK024906 
                 160613 
                 −0.26547427 
                   Homo sapiens  cDNA: 
               
               
                   
                   
                   
                   
                   
                 FLJ21253 fis, clone 
               
               
                   
                   
                   
                   
                   
                 COL01316 
               
               
                 HSAC017211 
                 0 
                 AK021887 
                 277001 
                 −0.26476404 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ11825 fis, clone 
               
               
                   
                   
                   
                   
                   
                 HEMBA1006494 
               
               
                 IDI1_HUMAN 
                 IDI1 
                 NM_004508 
                 76038 
                 −0.25999498 
                 Isopentenyl- 
               
               
                   
                   
                   
                   
                   
                 diphosphate delta 
               
               
                   
                   
                   
                   
                   
                 isomerase 
               
               
                 HSAC006238 
                 TMSB4X 
                 AK055976 
                 75968 
                 0.25632509 
                 Thymosin, beta 4, X 
               
               
                   
                   
                   
                   
                   
                 chromosome 
               
               
                 ETS2_HUMAN 
                 ETS2 
                 NM_005239 
                 85146 
                 −0.2516845 
                 V-ets erythroblastosis 
               
               
                   
                   
                   
                   
                   
                 virus E26 oncogene 
               
               
                   
                   
                   
                   
                   
                 homolog 2 (avian) 
               
               
                 SSB4_HUMAN 
                 MGC3181 
                 NM_032627 
                 324618 
                 0.24973691 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 MGC3181 
               
               
                 O60426 
                 FADS3 
                 NM_021727 
                 21765 
                 0.24927285 
                 Fatty acid desaturase 3 
               
               
                 LDHA_HUMAN 
                 LDHA 
                 NM_005566 
                 2795 
                 0.24753928 
                 Lactate dehydrogenase A 
               
               
                 KB15_HUMAN 
                 KIAA1115 
                 NM_014931 
                 72172 
                 −0.24331719 
                 KIAA1115 protein 
               
               
                 HSAC014795 
                 PLSCR1 
                 NM_021105 
                 198282 
                 −0.24294281 
                 Phospholipid 
               
               
                   
                   
                   
                   
                   
                 scramblase 1 
               
               
                 CO1A_HUMAN 
                 CORO1A 
                 NM_007074 
                 109606 
                 −0.24222576 
                 Coronin, actin binding 
               
               
                   
                   
                   
                   
                   
                 protein, 1A 
               
               
                 K1CP_HUMAN 
                 KRT16 
                 NM_005557 
                 115947 
                 −0.23828098 
                 Keratin 16 (focal non- 
               
               
                   
                   
                   
                   
                   
                 epidermolytic 
               
               
                   
                   
                   
                   
                   
                 palmoplantar 
               
               
                   
                   
                   
                   
                   
                 keratoderma) 
               
               
                 CT11_HUMAN 
                 C20orf11 
                 NM_017896 
                 103808 
                 0.23722689 
                 Chromosome 20 open 
               
               
                   
                   
                   
                   
                   
                 reading frame 11 
               
               
                 HSAC016239 
                 0 
                 AL049369 
                 250724 
                 −0.23637937 
                   Homo sapiens  mRNA; 
               
               
                   
                   
                   
                   
                   
                 cDNA 
               
               
                   
                   
                   
                   
                   
                 DKFZp586D0518 (from 
               
               
                   
                   
                   
                   
                   
                 clone 
               
               
                   
                   
                   
                   
                   
                 DKFZp586D0518) 
               
               
                 LDHA_HUMAN 
                 LDHA 
                 NM_005566 
                 2795 
                 0.23548608 
                 Lactate dehydrogenase A 
               
               
                 ST24_HUMAN 
                 STK24 
                 NM_003576 
                 168913 
                 −0.23478567 
                 Serine/threonine 
               
               
                   
                   
                   
                   
                   
                 kinase 24 (STE20 
               
               
                   
                   
                   
                   
                   
                 homolog, yeast) 
               
               
                 O60527 
                 SDCCAG8 
                 AF039690 
                 300642 
                 −0.23195532 
                 Serologically defined 
               
               
                   
                   
                   
                   
                   
                 colon cancer antigen 8 
               
               
                 HSAC018030 
                 0 
                 AL049275 
                 302051 
                 −0.23020458 
                   Homo sapiens  mRNA; 
               
               
                   
                   
                   
                   
                   
                 cDNA DKFZp564H213 
               
               
                   
                   
                   
                   
                   
                 (from clone 
               
               
                   
                   
                   
                   
                   
                 DKFZp564H213) 
               
               
                 HSAC018565 
                 0 
                 AK025194 
                 306784 
                 0.22999594 
                   Homo sapiens  cDNA: 
               
               
                   
                   
                   
                   
                   
                 FLJ21541 fis, clone 
               
               
                   
                   
                   
                   
                   
                 COL06166 
               
               
                 PO43_HUMAN 
                 POU4F3 
                 NM_002700 
                 248019 
                 −0.22881509 
                 POU domain, class 4, 
               
               
                   
                   
                   
                   
                   
                 transcription factor 3 
               
               
                 HSAC015174 
                 0 
                 AC006328 
                 213956 
                 0.22863598 
                   Homo sapiens  BAC 
               
               
                   
                   
                   
                   
                   
                 clone RP11-102O5 
               
               
                   
                   
                   
                   
                   
                 from Y 
               
               
                 Q9H0N3 
                 DKFZP566M1046 
                 NM_032127 
                 8039 
                 0.22863435 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 DKFZp566M1046 
               
               
                 7B2_HUMAN 
                 SGNE1 
                 NM_003020 
                 2265 
                 −0.22641912 
                 Secretory granule, 
               
               
                   
                   
                   
                   
                   
                 neuroendocrine protein 
               
               
                   
                   
                   
                   
                   
                 1 (7B2 protein) 
               
               
                 IP3S_HUMAN 
                 ITPR2 
                 NM_002223 
                 238272 
                 −0.2261709 
                 Inositol 1,4,5- 
               
               
                   
                   
                   
                   
                   
                 triphosphate receptor, 
               
               
                   
                   
                   
                   
                   
                 type 2 
               
               
                 Q9UEF2 
                 UBC 
                 M26880 
                 183704 
                 −0.22356958 
                 Ubiquitin C 
               
               
                 HSAC018590 
                 0 
                 AK025451 
                 306812 
                 −0.22302005 
                   Homo sapiens  cDNA: 
               
               
                   
                   
                   
                   
                   
                 FLJ21798 fis, clone 
               
               
                   
                   
                   
                   
                   
                 HEP00573 
               
               
                 Q8WY82 
                 0 
                 BC006284 
                 333388 
                 −0.22271485 
                   Homo sapiens , clone 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 3957135, 
               
               
                   
                   
                   
                   
                   
                 mRNA, partial cds 
               
               
                 TSP4_HUMAN 
                 THBS4 
                 NM_003248 
                 75774 
                 0.22139735 
                 Thrombospondin 4 
               
               
                 HSAC002075 
                 LOC51170 
                 NM_016245 
                 12150 
                 0.22091464 
                 Retinal short-chain 
               
               
                   
                   
                   
                   
                   
                 dehydrogenase/reductase 
               
               
                   
                   
                   
                   
                   
                 retSDR2 
               
               
                 HSAC009969 
                 0 
                 AK021935 
                 301153 
                 0.21899011 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ11873 fis, clone 
               
               
                   
                   
                   
                   
                   
                 HEMBA1007066 
               
               
                 HSAC007149 
                 0 
                 AL080078 
                 85335 
                 −0.21515156 
                   Homo sapiens  mRNA; 
               
               
                   
                   
                   
                   
                   
                 cDNA 
               
               
                   
                   
                   
                   
                   
                 DKFZp564D1462 (from 
               
               
                   
                   
                   
                   
                   
                 clone 
               
               
                   
                   
                   
                   
                   
                 DKFZp564D1462) 
               
               
                 MK01_HUMAN 
                 MAPK1 
                 AL157438 
                 324473 
                 0.21202447 
                 Mitogen-activated 
               
               
                   
                   
                   
                   
                   
                 protein kinase 1 
               
               
                 9KD_HUMAN 
                 MGC10471 
                 NM_030818 
                 24998 
                 −0.21138421 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 MGC10471 
               
               
                 HSAC018712 
                 KAP4.14 
                 NM_033059 
                 307015 
                 −0.21048412 
                 Keratin associated 
               
               
                   
                   
                   
                   
                   
                 protein 4.14 
               
               
                 TYPH_HUMAN 
                 ECGF1 
                 NM_001953 
                 73946 
                 −0.20356611 
                 Endothelial cell growth 
               
               
                   
                   
                   
                   
                   
                 factor 1 (platelet- 
               
               
                   
                   
                   
                   
                   
                 derived) 
               
               
                 Q9UBF4 
                 KIAA1036 
                 NM_014909 
                 155182 
                 0.20323707 
                 KIAA1036 protein 
               
               
                 CIQ5_HUMAN 
                 KCNQ5 
                 NM_019842 
                 283644 
                 0.20086104 
                 Potassium voltage- 
               
               
                   
                   
                   
                   
                   
                 gated channel, KQT- 
               
               
                   
                   
                   
                   
                   
                 like subfamily, member 5 
               
               
                 P39028 
                 RPS23 
                 NM_001025 
                 3463 
                 0.19967718 
                 Ribosomal protein S23 
               
               
                 NF3L_HUMAN 
                 NIF3L1 
                 NM_021824 
                 21943 
                 −0.18719016 
                 NIF3 NGG1 interacting 
               
               
                   
                   
                   
                   
                   
                 factor 3-like 1 ( S. pombe ) 
               
               
                 GTO1_HUMAN 
                 GSTTLp28 
                 NM_004832 
                 11465 
                 0.17999128 
                 Glutathione-S- 
               
               
                   
                   
                   
                   
                   
                 transferase like; 
               
               
                   
                   
                   
                   
                   
                 glutathione transferase 
               
               
                   
                   
                   
                   
                   
                 omega 
               
               
                 RAC2_HUMAN 
                 HSPC022 
                 NM_014029 
                 301175 
                 0.17873117 
                 HSPC022 protein 
               
               
                 Q9HAC8 
                 FLJ11807 
                 NM_024954 
                 285813 
                 0.17686817 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ11807 
               
               
                 RALA_HUMAN 
                 0 
                 AK026850 
                 6906 
                 0.17343054 
                   Homo sapiens  cDNA: 
               
               
                   
                   
                   
                   
                   
                 FLJ23197 fis, clone 
               
               
                   
                   
                   
                   
                   
                 REC00917 
               
               
                 CSR2_HUMAN 
                 CSRP2 
                 NM_001321 
                 10526 
                 0.17334591 
                 Cysteine and glycine- 
               
               
                   
                   
                   
                   
                   
                 rich protein 2 
               
               
                 HSAC019311 
                 0 
                 BC005220 
                 332008 
                 −0.17218654 
                   Homo sapiens , Similar 
               
               
                   
                   
                   
                   
                   
                 to chaperonin 
               
               
                   
                   
                   
                   
                   
                 containing TCP1, 
               
               
                   
                   
                   
                   
                   
                 subunit 8 (theta), clone 
               
               
                   
                   
                   
                   
                   
                 MGC: 12240 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 393033 
               
               
                 MNK2_HUMAN 
                 GPRK7 
                 NM_017572 
                 261828 
                 −0.16694331 
                 G protein-coupled 
               
               
                   
                   
                   
                   
                   
                 receptor kinase 7 
               
               
                 HSAC014448 
                 FLJ13385 
                 NM_024853 
                 190279 
                 −0.16552904 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ13385 
               
               
                 143F_HUMAN 
                 YWHAH 
                 NM_003405 
                 349530 
                 0.14759809 
                 Tyrosine 3- 
               
               
                   
                   
                   
                   
                   
                 monooxygenase/tryptophan 
               
               
                   
                   
                   
                   
                   
                 5- 
               
               
                   
                   
                   
                   
                   
                 monooxygenase 
               
               
                   
                   
                   
                   
                   
                 activation protein, eta 
               
               
                   
                   
                   
                   
                   
                 polypeptide 
               
               
                 Q96MZ7 
                 0 
                 AK056203 
                 323813 
                 0.1170698 
                   Homo sapiens , clone 
               
               
                   
                   
                   
                   
                   
                 MGC: 2867 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 2988664, 
               
               
                   
                   
                   
                   
                   
                 mRNA, complete cds 
               
               
                 LOXR_HUMAN 
                 ALOX12B 
                 NM_001139 
                 136574 
                 −0.33086759 
                 Arachidonate 12- 
               
               
                   
                   
                   
                   
                   
                 lipoxygenase, 12R type 
               
               
                 BD02_HUMAN 
                 DEFB2 
                 NM_004942 
                 105924 
                 −0.30510738 
                 Defensin, beta 2 
               
               
                 HSAC016948 
                 FLJ20433 
                 NM_017820 
                 272799 
                 −0.29024904 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ20433 
               
               
                 S112_HUMAN 
                 S100A12 
                 NM_005621 
                 19413 
                 −0.28725669 
                 S100 calcium binding 
               
               
                   
                   
                   
                   
                   
                 protein A12 
               
               
                   
                   
                   
                   
                   
                 (calgranulin C) 
               
               
                 HSAC018084 
                 0 
                 AF130062 
                 302146 
                 −0.25929293 
                   Homo sapiens  clone 
               
               
                   
                   
                   
                   
                   
                 FLB7715 PRO2051 
               
               
                   
                   
                   
                   
                   
                 mRNA, complete cds 
               
               
                 Q9NPA8 
                 DC6 
                 NM_020189 
                 283740 
                 0.25384995 
                 DC6 protein 
               
               
                 HSAC004275 
                 0 
                 AK001638 
                 34790 
                 −0.24604722 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ10776 fis, clone 
               
               
                   
                   
                   
                   
                   
                 NT2RP4000323 
               
               
                 HSAC018560 
                 0 
                 AK025177 
                 306778 
                 −0.24446302 
                   Homo sapiens  cDNA: 
               
               
                   
                   
                   
                   
                   
                 FLJ21524 fis, clone 
               
               
                   
                   
                   
                   
                   
                 COL05921 
               
               
                 HSAC020812 
                 0 
                 AK055957 
                 350815 
                 −0.24373933 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ31395 fis, clone 
               
               
                   
                   
                   
                   
                   
                 NT2NE1000122 
               
               
                 HSAC018421 
                 0 
                 AK022022 
                 306620 
                 −0.24043929 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ11960 fis, clone 
               
               
                   
                   
                   
                   
                   
                 HEMBB1001008 
               
               
                 O95204 
                 MP1 
                 NM_014889 
                 260116 
                 −0.23934663 
                 Metalloprotease 1 
               
               
                   
                   
                   
                   
                   
                 (pitrilysin family) 
               
               
                 Q96IC1 
                 AGRN 
                 AF016903 
                 273330 
                 0.23808476 
                 Agrin 
               
               
                 AKBA_HUMAN 
                 AKR1B10 
                 NM_020299 
                 116724 
                 −0.23802389 
                 Aldo-keto reductase 
               
               
                   
                   
                   
                   
                   
                 family 1, member B10 
               
               
                   
                   
                   
                   
                   
                 (aldose reductase) 
               
               
                 LDHA_HUMAN 
                 LDHA 
                 NM_005566 
                 2795 
                 0.23795266 
                 Lactate dehydrogenase A 
               
               
                 PTK6_HUMAN 
                 PTK6 
                 NM_005975 
                 51133 
                 −0.23581278 
                 PTK6 protein tyrosine 
               
               
                   
                   
                   
                   
                   
                 kinase 6 
               
               
                 NUOM_HUMAN 
                 NDUFV3 
                 NM_021075 
                 351217 
                 −0.23366493 
                 NADH dehydrogenase 
               
               
                   
                   
                   
                   
                   
                 (ubiquinone) 
               
               
                   
                   
                   
                   
                   
                 flavoprotein 3 (10 kD) 
               
               
                 GBP2_HUMAN 
                 GBP2 
                 NM_004120 
                 171862 
                 −0.23313126 
                 Guanylate binding 
               
               
                   
                   
                   
                   
                   
                 protein 2, interferon- 
               
               
                   
                   
                   
                   
                   
                 inducible 
               
               
                 Q9Y2I3 
                 KIAA0977 
                 NM_014900 
                 300855 
                 −0.23204872 
                 KIAA0977 protein 
               
               
                 ATS2_HUMAN 
                 ADAMTS2 
                 NM_014244 
                 120330 
                 0.2317392 
                 A disintegrin-like and 
               
               
                   
                   
                   
                   
                   
                 metalloprotease 
               
               
                   
                   
                   
                   
                   
                 (reprolysin type) with 
               
               
                   
                   
                   
                   
                   
                 thrombospondin type 1 
               
               
                   
                   
                   
                   
                   
                 motif, 2 
               
               
                 Q9P1G3 
                 PRO1853 
                 NM_018607 
                 52891 
                 −0.23061723 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 PRO1853 
               
               
                 Q92616 
                 GCN1L1 
                 D86973 
                 75354 
                 0.22882625 
                 GCN1 general control 
               
               
                   
                   
                   
                   
                   
                 of amino-acid synthesis 
               
               
                   
                   
                   
                   
                   
                 1-like 1 (yeast) 
               
               
                 SLI1_HUMAN 
                 FHL1 
                 NM_001449 
                 239069 
                 0.22601495 
                 Four and a half LIM 
               
               
                   
                   
                   
                   
                   
                 domains 1 
               
               
                 HSAC010091 
                 R33729_1 
                 Z78330 
                 10927 
                 −0.22537096 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 R33729_1 
               
               
                 S6AC_HUMAN 
                 SLC6A12 
                 U27699 
                 82535 
                 −0.22507903 
                 Solute carrier family 6 
               
               
                   
                   
                   
                   
                   
                 (neurotransmitter 
               
               
                   
                   
                   
                   
                   
                 transporter, 
               
               
                   
                   
                   
                   
                   
                 betaine/GABA), 
               
               
                   
                   
                   
                   
                   
                 member 12 
               
               
                 Y110_HUMAN 
                 KIAA0110 
                 NM_014628 
                 124 
                 0.22461245 
                 Gene predicted from 
               
               
                   
                   
                   
                   
                   
                 cDNA with a complete 
               
               
                   
                   
                   
                   
                   
                 coding sequence 
               
               
                 HSAC013952 
                 SP3 
                 X68560 
                 154295 
                 −0.22445276 
                 Sp3 transcription factor 
               
               
                 SYD_HUMAN 
                 DARS 
                 NM_001349 
                 80758 
                 0.22434629 
                 Aspartyl-tRNA 
               
               
                   
                   
                   
                   
                   
                 synthetase 
               
               
                 RL7_HUMAN 
                 RPL7 
                 NM_000971 
                 153 
                 0.22410736 
                 Ribosomal protein L7 
               
               
                 SNK_HUMAN 
                 SNK 
                 NM_006622 
                 3838 
                 −0.22350301 
                 Serum-inducible kinase 
               
               
                 ID3_HUMAN 
                 ID3 
                 NM_002167 
                 76884 
                 −0.22236535 
                 Inhibitor of DNA 
               
               
                   
                   
                   
                   
                   
                 binding 3, dominant 
               
               
                   
                   
                   
                   
                   
                 negative helix-loop- 
               
               
                   
                   
                   
                   
                   
                 helix protein 
               
               
                 RMP1_HUMAN 
                 RAMP1 
                 NM_005855 
                 32989 
                 0.22176553 
                 Receptor (calcitonin) 
               
               
                   
                   
                   
                   
                   
                 activity modifying 
               
               
                   
                   
                   
                   
                   
                 protein 1 
               
               
                 FK26_HUMAN 
                 KIAA1049 
                 NM_014972 
                 227835 
                 0.22124994 
                 KIAA1049 protein 
               
               
                 IEX1_HUMAN 
                 IER3 
                 NM_052815 
                 76095 
                 0.22091401 
                 Immediate early 
               
               
                   
                   
                   
                   
                   
                 response 3 
               
               
                 PTPK_HUMAN 
                 PTPRK 
                 NM_002844 
                 79005 
                 0.22006385 
                 Protein tyrosine 
               
               
                   
                   
                   
                   
                   
                 phosphatase, receptor 
               
               
                   
                   
                   
                   
                   
                 type, K 
               
               
                 HPS4_HUMAN 
                 0 
                 AK057648 
                 350640 
                 0.21953415 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ33086 fis, clone 
               
               
                   
                   
                   
                   
                   
                 TRACH2000461 
               
               
                 LDHB_HUMAN 
                 LDHB 
                 BC008952 
                 234489 
                 0.21684934 
                 Lactate dehydrogenase B 
               
               
                 Q8NDB6 
                 PRO0659 
                 AK054721 
                 6451 
                 0.21637177 
                 PRO0659 protein 
               
               
                 N7BM_HUMAN 
                 DAP13 
                 NM_018838 
                 44163 
                 −0.21579024 
                 13 kDa differentiation- 
               
               
                   
                   
                   
                   
                   
                 associated protein 
               
               
                 Q9H7Z7 
                 C9orf15 
                 NM_025072 
                 288102 
                 −0.21525058 
                 Chromosome 9 open 
               
               
                   
                   
                   
                   
                   
                 reading frame 15 
               
               
                 TM22_HUMAN 
                 TRIM22 
                 NM_006074 
                 318501 
                 −0.21520167 
                 Tripartite motif- 
               
               
                   
                   
                   
                   
                   
                 containing 22 
               
               
                 Q9H749 
                 DKFZP586D0919 
                 AL050100 
                 49378 
                 0.21169944 
                 DKFZP586D0919 
               
               
                   
                   
                   
                   
                   
                 protein 
               
               
                 Q969K7 
                 CAC-1 
                 NM_033504 
                 343912 
                 −0.21091675 
                 CAC-1 
               
               
                 OAS3_HUMAN 
                 OAS3 
                 NM_006187 
                 56009 
                 −0.20966638 
                 2′-5′-oligoadenylate 
               
               
                   
                   
                   
                   
                   
                 synthetase 3 (100 kD) 
               
               
                 PAN2_HUMAN 
                 PANX2 
                 NM_052839 
                 343259 
                 0.20929628 
                 Pannexin 2 
               
               
                 IFT1_HUMAN 
                 IFIT1 
                 NM_001548 
                 20315 
                 −0.20924493 
                 Interferon-induced 
               
               
                   
                   
                   
                   
                   
                 protein with 
               
               
                   
                   
                   
                   
                   
                 tetratricopeptide 
               
               
                   
                   
                   
                   
                   
                 repeats 1 
               
               
                 Q96HK5 
                 LOC51030 
                 NM_016078 
                 6776 
                 −0.20809385 
                 CGI-148 protein 
               
               
                 DDX3_HUMAN 
                 DDX3 
                 NM_001356 
                 147916 
                 −0.20803591 
                 DEAD/H (Asp-Glu-Ala- 
               
               
                   
                   
                   
                   
                   
                 Asp/His) box 
               
               
                   
                   
                   
                   
                   
                 polypeptide 3 
               
               
                 IF42_HUMAN 
                 EIF4A2 
                 NM_001967 
                 173912 
                 0.20756638 
                 Eukaryotic translation 
               
               
                   
                   
                   
                   
                   
                 initiation factor 4A, 
               
               
                   
                   
                   
                   
                   
                 isoform 2 
               
               
                 Q9NPI0 
                 0 
                 AK027724 
                 334557 
                 −0.20655815 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ14818 fis, clone 
               
               
                   
                   
                   
                   
                   
                 OVARC1000168 
               
               
                 P11082 
                 PPP2CB 
                 NM_004156 
                 80350 
                 −0.20633072 
                 Protein phosphatase 2 
               
               
                   
                   
                   
                   
                   
                 (formerly 2A), catalytic 
               
               
                   
                   
                   
                   
                   
                 subunit, beta isoform 
               
               
                 HSAC004729 
                 0 
                 AK021604 
                 44787 
                 −0.20569729 
                   Homo sapiens  mRNA; 
               
               
                   
                   
                   
                   
                   
                 cDNA 
               
               
                   
                   
                   
                   
                   
                 DKFZp434O0227 (from 
               
               
                   
                   
                   
                   
                   
                 clone 
               
               
                   
                   
                   
                   
                   
                 DKFZp434O0227) 
               
               
                 THTR_HUMAN 
                 TST 
                 NM_003312 
                 351863 
                 −0.20339936 
                 Thiosulfate 
               
               
                   
                   
                   
                   
                   
                 sulfurtransferase 
               
               
                   
                   
                   
                   
                   
                 (rhodanese) 
               
               
                 APL1_HUMAN 
                 APOL1 
                 AF323540 
                 114309 
                 −0.2014645 
                 Apolipoprotein L, 1 
               
               
                 Q96IP9 
                 H41 
                 AF103803 
                 283690 
                 −0.19892848 
                 Hypothetical protein 
               
               
                 PSB5_HUMAN 
                 PSMB5 
                 NM_002797 
                 78596 
                 0.19884452 
                 Proteasome (prosome, 
               
               
                   
                   
                   
                   
                   
                 macropain) subunit, 
               
               
                   
                   
                   
                   
                   
                 beta type, 5 
               
               
                 Q96MH6 
                 0 
                 AK056932 
                 280858 
                 −0.19855951 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ32370 fis, clone 
               
               
                   
                   
                   
                   
                   
                 PUAEN1000322 
               
               
                 Q96DR8 
                 LOC118430 
                 NM_058173 
                 348419 
                 −0.19728271 
                 Small breast epithelial 
               
               
                   
                   
                   
                   
                   
                 mucin 
               
               
                 HSAC020134 
                 0 
                 BG912466 
                 347715 
                 −0.19659403 
                   Homo sapiens  mRNA 
               
               
                   
                   
                   
                   
                   
                 full length insert cDNA 
               
               
                   
                   
                   
                   
                   
                 clone EUROIMAGE 
               
               
                   
                   
                   
                   
                   
                 152428 
               
               
                 APA1_HUMAN 
                 APOA1 
                 NM_000039 
                 93194 
                 0.19456431 
                 Apolipoprotein A-I 
               
               
                 IKBA_HUMAN 
                 NFKBIA 
                 NM_020529 
                 81328 
                 0.19434039 
                 Nuclear factor of kappa 
               
               
                   
                   
                   
                   
                   
                 light polypeptide gene 
               
               
                   
                   
                   
                   
                   
                 enhancer in B-cells 
               
               
                   
                   
                   
                   
                   
                 inhibitor, alpha 
               
               
                 S61G_HUMAN 
                 SEC61G 
                 NM_014302 
                 9950 
                 0.19385443 
                 Sec61 gamma 
               
               
                 Q8TB66 
                 NIFK 
                 NM_032390 
                 142838 
                 0.19235852 
                 Nucleolar protein 
               
               
                   
                   
                   
                   
                   
                 interacting with the 
               
               
                   
                   
                   
                   
                   
                 FHA domain of pKi-67 
               
               
                 FXLA_HUMAN 
                 PCCX2 
                 AB031230 
                 199009 
                 −0.19227016 
                 Protein containing 
               
               
                   
                   
                   
                   
                   
                 CXXC domain 2 
               
               
                 HSAC005389 
                 PRO2086 
                 NM_014111 
                 60082 
                 −0.19183233 
                 PRO2086 protein 
               
               
                 TGDS_HUMAN 
                 TDPGD 
                 NM_014305 
                 12393 
                 0.19120788 
                 DTDP-D-glucose 4,6- 
               
               
                   
                   
                   
                   
                   
                 dehydratase 
               
               
                 Q9NYL1 
                 PTOV1 
                 NM_017432 
                 19555 
                 0.18942731 
                 Prostate tumor over 
               
               
                   
                   
                   
                   
                   
                 expressed gene 1 
               
               
                 RET7_HUMAN 
                 RBP7 
                 NM_052960 
                 292718 
                 0.18902609 
                 Retinoid binding 
               
               
                   
                   
                   
                   
                   
                 protein 7 
               
               
                 Q9H5V9 
                 FLJ22965 
                 NM_022101 
                 248572 
                 0.18655842 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ22965 
               
               
                 O94911 
                 ABCA8 
                 NM_007168 
                 38095 
                 −0.18602829 
                 ATP-binding cassette, 
               
               
                   
                   
                   
                   
                   
                 sub-family A (ABC1), 
               
               
                   
                   
                   
                   
                   
                 member 8 
               
               
                 AAH50307 
                 MORC 
                 NM_014429 
                 278908 
                 −0.18567819 
                 Microrchidia homolog 
               
               
                   
                   
                   
                   
                   
                 (mouse) 
               
               
                 TR1B_HUMAN 
                 TNFRSF1B 
                 NM_001066 
                 256278 
                 0.18560882 
                 Tumor necrosis factor 
               
               
                   
                   
                   
                   
                   
                 receptor superfamily, 
               
               
                   
                   
                   
                   
                   
                 member 1B 
               
               
                 HS71_HUMAN 
                 HSPA1A 
                 NM_005345 
                 8997 
                 0.18329446 
                 Heat shock 70 kD 
               
               
                   
                   
                   
                   
                   
                 protein 1A 
               
               
                 Q9C086 
                 PAPA-1 
                 NM_031288 
                 118282 
                 −0.18173371 
                 PAP-1 binding protein 
               
               
                 HSAC005625 
                 0 
                 AL050367 
                 66762 
                 0.17583034 
                   Homo sapiens  mRNA; 
               
               
                   
                   
                   
                   
                   
                 cDNA DKFZp564A026 
               
               
                   
                   
                   
                   
                   
                 (from clone 
               
               
                   
                   
                   
                   
                   
                 DKFZp564A026) 
               
               
                 HSAC000871 
                 0 
                 AK024270 
                 4094 
                 0.17415618 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ14208 fis, clone 
               
               
                   
                   
                   
                   
                   
                 NT2RP3003264 
               
               
                 Q9H655 
                 FLJ22595 
                 NM_025047 
                 287702 
                 −0.17240792 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ22595 
               
               
                 HSAC018574 
                 0 
                 AK025291 
                 306794 
                 −0.16937687 
                   Homo sapiens  cDNA: 
               
               
                   
                   
                   
                   
                   
                 FLJ21638 fis, clone 
               
               
                   
                   
                   
                   
                   
                 COL08269 
               
               
                 Q9UK76 
                 HN1 
                 NM_016185 
                 109706 
                 0.16129563 
                 Hematological and 
               
               
                   
                   
                   
                   
                   
                 neurological expressed 1 
               
               
                 INI2_HUMAN 
                 G1P3 
                 NM_022873 
                 265827 
                 −0.15984033 
                 Interferon, alpha- 
               
               
                   
                   
                   
                   
                   
                 inducible protein (clone 
               
               
                   
                   
                   
                   
                   
                 IFI-6-16) 
               
               
                 HRG_HUMAN 
                 HRG 
                 NM_000412 
                 1498 
                 0.15777333 
                 Histidine-rich 
               
               
                   
                   
                   
                   
                   
                 glycoprotein 
               
               
                 Q9ULD2 
                 ATIP1 
                 AB033114 
                 7946 
                 −0.15367977 
                 AT2 receptor- 
               
               
                   
                   
                   
                   
                   
                 interacting protein 1 
               
               
                 TRBM_HUMAN 
                 THBD 
                 NM_000361 
                 2030 
                 −0.1417714 
                 Thrombomodulin 
               
               
                 HSAC015082 
                 0 
                 AK023326 
                 210844 
                 −0.13617964 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ13264 fis, clone 
               
               
                   
                   
                   
                   
                   
                 OVARC1000936, 
               
               
                   
                   
                   
                   
                   
                 weakly similar to COAT 
               
               
                   
                   
                   
                   
                   
                 PROTEIN GP37 
               
               
                 HSAC002372 
                 0 
                 AK023269 
                 14355 
                 0.13539305 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ13207 fis, clone 
               
               
                   
                   
                   
                   
                   
                 NT2RP4000023 
               
               
                 ITB4_HUMAN 
                 ITGB4 
                 NM_000213 
                 85266 
                 0.12885959 
                 Integrin, beta 4 
               
               
                 HSAC013491 
                 0 
                 AL157491 
                 145211 
                 −0.11058947 
                   Homo sapiens  mRNA; 
               
               
                   
                   
                   
                   
                   
                 cDNA 
               
               
                   
                   
                   
                   
                   
                 DKFZp434K1111 (from 
               
               
                   
                   
                   
                   
                   
                 clone 
               
               
                   
                   
                   
                   
                   
                 DKFZp434K1111) 
               
               
                 Q8TAD5 
                 SPANXB1 
                 NM_032461 
                 293266 
                 0.08476128 
                 SPANX family, 
               
               
                   
                   
                   
                   
                   
                 member B1 
               
               
                 Q96SV0 
                 FLJ14621 
                 NM_032811 
                 10056 
                 −0.08227502 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ14621 
               
               
                 Q9ULE7 
                 KIAA1273 
                 AB033099 
                 23413 
                 −0.05093065 
                 KIAA1273 protein 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
               
               
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 4 
               
             
             
               
                   
               
               
                 List of 179 genes with strong predictive value 
               
             
          
           
               
                   
                   
                   
                   
                 N+ 
                   
               
               
                 UniProt 
                 Gene_symbol 
                 GB_accession 
                 UniGene_ID 
                 correlation 
                 Gene 
               
               
                   
               
             
          
           
               
                 Q9NZQ6 
                 COL5A3 
                 NM_015719 
                 235368 
                 0.57481098 
                 Collagen, type V, alpha 3 
               
               
                 FINC_HUMAN 
                 FN1 
                 NM_002026 
                 287820 
                 0.55126846 
                 Fibronectin 1 
               
               
                 FSL1_HUMAN 
                 FSTL1 
                 NM_007085 
                 296267 
                 0.53452734 
                 Follistatin-like 1 
               
               
                 ER22_HUMAN 
                 KDELR2 
                 NM_006854 
                 118778 
                 0.52986731 
                 KDEL (Lys-Asp-Glu- 
               
               
                   
                   
                   
                   
                   
                 Leu) endoplasmic 
               
               
                   
                   
                   
                   
                   
                 reticulum protein 
               
               
                   
                   
                   
                   
                   
                 retention receptor 2 
               
               
                 PCO1_HUMAN 
                 PCOLCE 
                 NM_002593 
                 202097 
                 0.52672595 
                 Procollagen C- 
               
               
                   
                   
                   
                   
                   
                 endopeptidase 
               
               
                   
                   
                   
                   
                   
                 enhancer 
               
               
                 SPRC_HUMAN 
                 SPARC 
                 NM_003118 
                 111779 
                 0.51922531 
                 Secreted protein, 
               
               
                   
                   
                   
                   
                   
                 acidic, cysteine-rich 
               
               
                   
                   
                   
                   
                   
                 (osteonectin) 
               
               
                 NC5R_HUMAN 
                 DIA1 
                 NM_007326 
                 274464 
                 0.51482855 
                 Diaphorase (NADH) 
               
               
                   
                   
                   
                   
                   
                 (cytochrome b-5 
               
               
                   
                   
                   
                   
                   
                 reductase) 
               
               
                 SEPR_HUMAN 
                 FAP 
                 NM_004460 
                 418 
                 0.51466336 
                 Fibroblast activation 
               
               
                   
                   
                   
                   
                   
                 protein, alpha 
               
               
                 HSAC013564 
                 COL5A1 
                 NM_000093 
                 146428 
                 0.51225806 
                 Collagen, type V, alpha 
               
               
                   
                   
                   
                   
                   
                 1 
               
               
                 HSAC009848 
                 ZFP93 
                 NM_004234 
                 298089 
                 0.50989391 
                 Zinc finger protein 93 
               
               
                   
                   
                   
                   
                   
                 homolog (mouse) 
               
               
                 PGCV_HUMAN 
                 CSPG2 
                 U16306 
                 81800 
                 0.50906177 
                 Chondroitin sulfate 
               
               
                   
                   
                   
                   
                   
                 proteoglycan 2 
               
               
                   
                   
                   
                   
                   
                 (versican) 
               
               
                 Q14521 
                 LLGL2 
                 NM_004524 
                 3123 
                 −0.50695888 
                 Lethal giant larvae 
               
               
                   
                   
                   
                   
                   
                 homolog 2 ( Drosophila ) 
               
               
                 CA14_HUMAN 
                 COL4A1 
                 NM_001845 
                 119129 
                 0.50664753 
                 Collagen, type IV, 
               
               
                   
                   
                   
                   
                   
                 alpha 1 
               
               
                 HSAC014709 
                 TEM1 
                 NM_020404 
                 195727 
                 0.50647843 
                 Tumor endothelial 
               
               
                   
                   
                   
                   
                   
                 marker 1 precursor 
               
               
                 UROK_HUMAN 
                 PLAU 
                 NM_002658 
                 77274 
                 0.50439834 
                 Plasminogen activator, 
               
               
                   
                   
                   
                   
                   
                 urokinase 
               
               
                 Q8N6P7 
                 IL22R 
                 NM_021258 
                 110915 
                 −0.49928496 
                 Interleukin 22 receptor 
               
               
                 LEG1_HUMAN 
                 LGALS1 
                 NM_002305 
                 227751 
                 0.48740219 
                 Lectin, galactoside- 
               
               
                   
                   
                   
                   
                   
                 binding, soluble, 1 
               
               
                   
                   
                   
                   
                   
                 (galectin 1) 
               
               
                 CA25_HUMAN 
                 COL5A2 
                 NM_000393 
                 82985 
                 0.48675513 
                 Collagen, type V, alpha 
               
               
                   
                   
                   
                   
                   
                 2 
               
               
                 CA13_HUMAN 
                 COL3A1 
                 NM_000090 
                 119571 
                 0.48459913 
                 Collagen, type III, 
               
               
                   
                   
                   
                   
                   
                 alpha 1 (Ehlers-Danlos 
               
               
                   
                   
                   
                   
                   
                 syndrome type IV, 
               
               
                   
                   
                   
                   
                   
                 autosomal dominant) 
               
               
                 Q9BYD5 
                 LOC84518 
                 NM_032488 
                 148590 
                 −0.48449285 
                 Protein related with 
               
               
                   
                   
                   
                   
                   
                 psoriasis 
               
               
                 BGH3_HUMAN 
                 TGFBI 
                 NM_000358 
                 118787 
                 0.48290139 
                 Transforming growth 
               
               
                   
                   
                   
                   
                   
                 factor, beta-induced, 
               
               
                   
                   
                   
                   
                   
                 68 kD 
               
               
                 CQT6_HUMAN 
                 CTRP6 
                 NM_031910 
                 22011 
                 0.47978614 
                 Complement-c1q tumor 
               
               
                   
                   
                   
                   
                   
                 necrosis factor-related 
               
               
                   
                   
                   
                   
                   
                 protein 6 
               
               
                 AD12_HUMAN 
                 ADAM12 
                 NM_003474 
                 8850 
                 0.47905457 
                 A disintegrin and 
               
               
                   
                   
                   
                   
                   
                 metalloproteinase 
               
               
                   
                   
                   
                   
                   
                 domain 12 (meltrin 
               
               
                   
                   
                   
                   
                   
                 alpha) 
               
               
                 Q8N3N2 
                 FLJ11196 
                 NM_018357 
                 6166 
                 0.47772636 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ11196 
               
               
                 CATK_HUMAN 
                 CTSK 
                 NM_000396 
                 83942 
                 0.47734967 
                 Cathepsin K 
               
               
                   
                   
                   
                   
                   
                 (pycnodysostosis) 
               
               
                 Q96DR2 
                 0 
                 AK055031 
                 44289 
                 −0.47659518 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ30469 fis, clone 
               
               
                   
                   
                   
                   
                   
                 BRAWH1000037, 
               
               
                   
                   
                   
                   
                   
                 weakly similar to 
               
               
                   
                   
                   
                   
                   
                 UROKINASE 
               
               
                   
                   
                   
                   
                   
                 PLASMINOGEN 
               
               
                   
                   
                   
                   
                   
                 ACTIVATO 
               
               
                 P03996 
                 ACTA2 
                 NM_001613 
                 195851 
                 0.47560995 
                 Actin, alpha 2, smooth 
               
               
                   
                   
                   
                   
                   
                 muscle, aorta 
               
               
                 K6A2_HUMAN 
                 0 
                 AK027727 
                 184581 
                 0.47396182 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ14821 fis, clone 
               
               
                   
                   
                   
                   
                   
                 OVARC1000556, 
               
               
                   
                   
                   
                   
                   
                 highly similar to 
               
               
                   
                   
                   
                   
                   
                 RIBOSOMAL 
               
               
                   
                   
                   
                   
                   
                 PROTEIN S6 KINASE 
               
               
                   
                   
                   
                   
                   
                 II 
               
               
                 Q9HBB0 
                 THY1 
                 AK057865 
                 125359 
                 0.4727028 
                 Thy-1 cell surface 
               
               
                   
                   
                   
                   
                   
                 antigen 
               
               
                 TM29_HUMAN 
                 TRIM29 
                 NM_012101 
                 82237 
                 −0.47250994 
                 Tripartite motif- 
               
               
                   
                   
                   
                   
                   
                 containing 29 
               
               
                 TIM2_HUMAN 
                 0 
                 AL110197 
                 6441 
                 0.47199573 
                   Homo sapiens  mRNA; 
               
               
                   
                   
                   
                   
                   
                 cDNA DKFZp586J021 
               
               
                   
                   
                   
                   
                   
                 (from clone 
               
               
                   
                   
                   
                   
                   
                 DKFZp586J021) 
               
               
                 MM02_HUMAN 
                 MMP2 
                 NM_004530 
                 111301 
                 0.47026319 
                 Matrix 
               
               
                   
                   
                   
                   
                   
                 metalloproteinase 2 
               
               
                   
                   
                   
                   
                   
                 (gelatinase A, 72 kD 
               
               
                   
                   
                   
                   
                   
                 gelatinase, 72 kD type 
               
               
                   
                   
                   
                   
                   
                 IV collagenase) 
               
               
                 MCA2_HUMAN 
                 JTV1 
                 NM_006303 
                 301613 
                 0.46964142 
                 JTV1 gene 
               
               
                 CA16_HUMAN 
                 COL6A1 
                 NM_001848 
                 108885 
                 0.46942561 
                 Collagen, type VI, 
               
               
                   
                   
                   
                   
                   
                 alpha 1 
               
               
                 EVA1_HUMAN 
                 EVA1 
                 AF275945 
                 116651 
                 −0.4689165 
                 Epithelial V-like antigen 
               
               
                   
                   
                   
                   
                   
                 1 
               
               
                 CA21_HUMAN 
                 COL1A2 
                 NM_000089 
                 179573 
                 0.46739585 
                 Collagen, type I, alpha 
               
               
                   
                   
                   
                   
                   
                 2 
               
               
                 CA36_HUMAN 
                 COL6A3 
                 NM_004369 
                 80988 
                 0.46507048 
                 Collagen, type VI, 
               
               
                   
                   
                   
                   
                   
                 alpha 3 
               
               
                 OPN3_HUMAN 
                 OPN3 
                 NM_014322 
                 279926 
                 0.46101056 
                 Opsin 3 
               
               
                   
                   
                   
                   
                   
                 (encephalopsin, 
               
               
                   
                   
                   
                   
                   
                 panopsin) 
               
               
                 Q9UBG0 
                 KIAA0709 
                 NM_006039 
                 7835 
                 0.46012143 
                 Endocytic receptor 
               
               
                   
                   
                   
                   
                   
                 (macrophage mannose 
               
               
                   
                   
                   
                   
                   
                 receptor family) 
               
               
                 TPM2_HUMAN 
                 TPM2 
                 NM_003289 
                 300772 
                 0.46003075 
                 Tropomyosin 2 (beta) 
               
               
                 INVO_HUMAN 
                 IVL 
                 NM_005547 
                 157091 
                 −0.45860578 
                 Involucrin 
               
               
                 O88386 
                 RAB10 
                 NM_016131 
                 236494 
                 −0.45006586 
                 RAB10, member RAS 
               
               
                   
                   
                   
                   
                   
                 oncogene family 
               
               
                 PEPL_HUMAN 
                 PPL 
                 NM_002705 
                 74304 
                 −0.44874989 
                 Periplakin 
               
               
                 HSAC002603 
                 FLJ11036 
                 NM_018306 
                 16740 
                 −0.44841185 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ11036 
               
               
                 TNR5_HUMAN 
                 TNFRSF5 
                 NM_001250 
                 25648 
                 −0.44547341 
                 Tumor necrosis factor 
               
               
                   
                   
                   
                   
                   
                 receptor superfamily, 
               
               
                   
                   
                   
                   
                   
                 member 5 
               
               
                 FRIH_HUMAN 
                 FTH1 
                 AK054816 
                 62954 
                 0.4396982 
                 Ferritin, heavy 
               
               
                   
                   
                   
                   
                   
                 polypeptide 1 
               
               
                 P4H2_HUMAN 
                 P4HA2 
                 NM_004199 
                 3622 
                 0.42478412 
                 Procollagen-proline, 2- 
               
               
                   
                   
                   
                   
                   
                 oxoglutarate 4- 
               
               
                   
                   
                   
                   
                   
                 dioxygenase (proline 4- 
               
               
                   
                   
                   
                   
                   
                 hydroxylase), alpha 
               
               
                   
                   
                   
                   
                   
                 polypeptide II 
               
               
                 P09526 
                 RAP1B 
                 NM_015646 
                 156764 
                 0.42234208 
                 RAP1B, member of 
               
               
                   
                   
                   
                   
                   
                 RAS oncogene family 
               
               
                 PS23_HUMAN 
                 SPUVE 
                 NM_007173 
                 25338 
                 0.42080095 
                 Protease, serine, 23 
               
               
                 HSAC011159 
                 0 
                 AF009267 
                 102238 
                 −0.46560322 
                   Homo sapiens  clone 
               
               
                   
                   
                   
                   
                   
                 FBA1 Cri-du-chat 
               
               
                   
                   
                   
                   
                   
                 region mRNA 
               
               
                 SDC2_HUMAN 
                 SDC2 
                 J04621 
                 1501 
                 0.45455196 
                 Syndecan 2 (heparan 
               
               
                   
                   
                   
                   
                   
                 sulfate proteoglycan 1, 
               
               
                   
                   
                   
                   
                   
                 cell surface-associated, 
               
               
                   
                   
                   
                   
                   
                 fibroglycan) 
               
               
                 HSAC013320 
                 0 
                 AL162069 
                 140978 
                 −0.44362782 
                   Homo sapiens  mRNA; 
               
               
                   
                   
                   
                   
                   
                 cDNA DKFZp762H106 
               
               
                   
                   
                   
                   
                   
                 (from clone 
               
               
                   
                   
                   
                   
                   
                 DKFZp762H106) 
               
               
                 TAGL_HUMAN 
                 TAGLN 
                 NM_003186 
                 75777 
                 0.4376112 
                 Transgelin 
               
               
                 MM01_HUMAN 
                 MMP1 
                 NM_002421 
                 83169 
                 0.4326825 
                 Matrix 
               
               
                   
                   
                   
                   
                   
                 metalloproteinase 1 
               
               
                   
                   
                   
                   
                   
                 (interstitial 
               
               
                   
                   
                   
                   
                   
                 collagenase) 
               
               
                 P05209 
                 K-ALPHA-1 
                 NM_006082 
                 334842 
                 0.42236541 
                 Tubulin, alpha, 
               
               
                   
                   
                   
                   
                   
                 ubiquitous 
               
               
                 TSP2_HUMAN 
                 THBS2 
                 NM_003247 
                 108623 
                 0.46791583 
                 Thrombospondin 2 
               
               
                 Q8N789 
                 DKFZP4 
                 AL137589 
                 152149 
                 −0.43787021 
                 Hypothetical protein 
               
               
                   
                 34K0410 
                   
                   
                   
                 DKFZp434K0410 
               
               
                 O60335 
                 KIAA0594 
                 AB011166 
                 103283 
                 −0.42578156 
                 KIAA0594 protein 
               
               
                 P05209 
                 K-ALPHA-1 
                 NM_006082 
                 334842 
                 0.42277793 
                 Tubulin, alpha, 
               
               
                   
                   
                   
                   
                   
                 ubiquitous 
               
               
                 TNI3_HUMAN 
                 TNFAIP3 
                 NM_006290 
                 211600 
                 0.408128 
                 Tumor necrosis factor, 
               
               
                   
                   
                   
                   
                   
                 alpha-induced protein 3 
               
               
                 FGR1_HUMAN 
                 FGFR1 
                 NM_023109 
                 748 
                 0.43553561 
                 Fibroblast growth factor 
               
               
                   
                   
                   
                   
                   
                 receptor 1 (fms-related 
               
               
                   
                   
                   
                   
                   
                 tyrosine kinase 2, 
               
               
                   
                   
                   
                   
                   
                 Pfeiffer syndrome) 
               
               
                 CAD2_HUMAN 
                 CDH2 
                 NM_001792 
                 161 
                 0.3922152 
                 Cadherin 2, type 1, N- 
               
               
                   
                   
                   
                   
                   
                 cadherin (neuronal) 
               
               
                 TCOF_HUMAN 
                 TCOF1 
                 NM_000356 
                 301266 
                 0.38956707 
                 Treacher Collins- 
               
               
                   
                   
                   
                   
                   
                 Franceschetti 
               
               
                   
                   
                   
                   
                   
                 syndrome 1 
               
               
                 O14635 
                 0 
                 AF005082 
                 113261 
                 −0.45637623 
                   Homo sapiens  skin- 
               
               
                   
                   
                   
                   
                   
                 specific protein (xp33) 
               
               
                   
                   
                   
                   
                   
                 mRNA, partial cds 
               
               
                 GLSK_HUMAN 
                 GLS 
                 NM_014905 
                 239189 
                 0.43214995 
                 Glutaminase 
               
               
                 Q9BRJ6 
                 MGC11257 
                 NM_032350 
                 334368 
                 0.42954566 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 MGC11257 
               
               
                 ALK1_HUMAN 
                 SLPI 
                 NM_003064 
                 251754 
                 −0.41872706 
                 Secretory leukocyte 
               
               
                   
                   
                   
                   
                   
                 protease inhibitor 
               
               
                   
                   
                   
                   
                   
                 (antileukoproteinase) 
               
               
                 AQP3_HUMAN 
                 AQP3 
                 NM_004925 
                 234642 
                 −0.42891866 
                 Aquaporin 3 
               
               
                 SPIB_HUMAN 
                 SPIB 
                 NM_003121 
                 192861 
                 −0.41021146 
                 Spi-B transcription 
               
               
                   
                   
                   
                   
                   
                 factor (Spi-1/PU.1 
               
               
                   
                   
                   
                   
                   
                 related) 
               
               
                 P05209 
                 K-ALPHA-1 
                 NM_006082 
                 334842 
                 0.41796901 
                 Tubulin, alpha, 
               
               
                   
                   
                   
                   
                   
                 ubiquitous 
               
               
                 DRG1_HUMAN 
                 DRG1 
                 NM_004147 
                 115242 
                 0.41879372 
                 Developmentally 
               
               
                   
                   
                   
                   
                   
                 regulated GTP binding 
               
               
                   
                   
                   
                   
                   
                 protein 1 
               
               
                 PHMX_HUMAN 
                 PHEMX 
                 NM_005705 
                 271954 
                 0.38728757 
                 Pan-hematopoietic 
               
               
                   
                   
                   
                   
                   
                 expression 
               
               
                 P05209 
                 K-ALPHA-1 
                 NM_006082 
                 334842 
                 0.41741385 
                 Tubulin, alpha, 
               
               
                   
                   
                   
                   
                   
                 ubiquitous 
               
               
                 HSAC018335 
                 0 
                 AL137428 
                 306459 
                 −0.45404252 
                   Homo sapiens  mRNA; 
               
               
                   
                   
                   
                   
                   
                 cDNA 
               
               
                   
                   
                   
                   
                   
                 DKFZp761N1323 (from 
               
               
                   
                   
                   
                   
                   
                 clone 
               
               
                   
                   
                   
                   
                   
                 DKFZp761N1323) 
               
               
                 POSN_HUMAN 
                 OSF-2 
                 NM_006475 
                 136348 
                 0.42814786 
                 Osteoblast specific 
               
               
                   
                   
                   
                   
                   
                 factor 2 (fasciclin I-like) 
               
               
                 DHC3_HUMAN 
                 CBR3 
                 NM_001236 
                 154510 
                 −0.48089013 
                 Carbonyl reductase 3 
               
               
                 NCR2_HUMAN 
                 NCOR2 
                 NM_006312 
                 287994 
                 0.42024512 
                 Nuclear receptor co- 
               
               
                   
                   
                   
                   
                   
                 repressor 2 
               
               
                 HSAC015262 
                 0 
                 AK021531 
                 224398 
                 0.43632187 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ11469 fis, clone 
               
               
                   
                   
                   
                   
                   
                 HEMBA1001658 
               
               
                 Q14113 
                 AEBP1 
                 NM_001129 
                 118397 
                 0.42087649 
                 AE binding protein 1 
               
               
                 TBX2_HUMAN 
                 TBX2 
                 AK001031 
                 322856 
                 0.41381789 
                 T-box 2 
               
               
                 CRF_HUMAN 
                 CRH 
                 NM_000756 
                 75294 
                 −0.41353804 
                 Corticotropin releasing 
               
               
                   
                   
                   
                   
                   
                 hormone 
               
               
                 Q9NUJ7 
                 FLJ11323 
                 NM_018390 
                 25625 
                 −0.43842923 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ11323 
               
               
                 Q96DU1 
                 AKAP2 
                 AJ303079 
                 42322 
                 −0.44106809 
                 A kinase (PRKA) 
               
               
                   
                   
                   
                   
                   
                 anchor protein 2 
               
               
                 P05209 
                 K-ALPHA-1 
                 NM_006082 
                 334842 
                 0.40736744 
                 Tubulin, alpha, 
               
               
                   
                   
                   
                   
                   
                 ubiquitous 
               
               
                 Q969Y7 
                 MGC4677 
                 NM_052871 
                 337986 
                 0.39455354 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 MGC4677 
               
               
                 Q9BXY6 
                 FLJ13962 
                 NM_024862 
                 330407 
                 −0.44327759 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ13962 
               
               
                 K1CW_HUMAN 
                 HAIK1 
                 NM_015515 
                 9029 
                 −0.42594883 
                 Type I intermediate 
               
               
                   
                   
                   
                   
                   
                 filament cytokeratin 
               
               
                 HSAC019114 
                 FLJ22622 
                 NM_025151 
                 324841 
                 −0.4331912 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ22622 
               
               
                 PGS2_HUMAN 
                 DCN 
                 NM_001920 
                 76152 
                 0.39882715 
                 Decorin 
               
               
                 DCOP_HUMAN 
                 ODC-p 
                 NM_052998 
                 91681 
                 −0.41609162 
                 Ornithine 
               
               
                   
                   
                   
                   
                   
                 decarboxylase-like 
               
               
                   
                   
                   
                   
                   
                 protein 
               
               
                 HSAC020747 
                 0 
                 AK056828 
                 350748 
                 −0.40822563 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ32266 fis, clone 
               
               
                   
                   
                   
                   
                   
                 PROST1000419 
               
               
                 P05209 
                 K-ALPHA-1 
                 NM_006082 
                 334842 
                 0.39997295 
                 Tubulin, alpha, 
               
               
                   
                   
                   
                   
                   
                 ubiquitous 
               
               
                 Q96F00 
                 0 
                 AK025719 
                 251664 
                 0.39457176 
                   Homo sapiens  cDNA: 
               
               
                   
                   
                   
                   
                   
                 FLJ22066 fis, clone 
               
               
                   
                   
                   
                   
                   
                 HEP10611 
               
               
                 ISK5_HUMAN 
                 SPINK5 
                 NM_006846 
                 331555 
                 −0.43770884 
                 Serine protease 
               
               
                   
                   
                   
                   
                   
                 inhibitor, Kazal type, 5 
               
               
                 GFR1_HUMAN 
                 GFRA1 
                 NM_005264 
                 105445 
                 0.37859516 
                 GDNF family receptor 
               
               
                   
                   
                   
                   
                   
                 alpha 1 
               
               
                 AAF24516 
                 NUDEL 
                 NM_030808 
                 3850 
                 −0.40726277 
                 LIS1-interacting protein 
               
               
                   
                   
                   
                   
                   
                 NUDEL; 
               
               
                   
                   
                   
                   
                   
                 endooligopeptidase A 
               
               
                 P05209 
                 K-ALPHA-1 
                 NM_006082 
                 334842 
                 0.39594293 
                 Tubulin, alpha, 
               
               
                   
                   
                   
                   
                   
                 ubiquitous 
               
               
                 O60836 
                 T1A-2 
                 NM_013317 
                 135150 
                 0.37127534 
                 Lung type-I cell 
               
               
                   
                   
                   
                   
                   
                 membrane-associated 
               
               
                   
                   
                   
                   
                   
                 glycoprotein 
               
               
                 KLKA_HUMAN 
                 KLK10 
                 NM_002776 
                 69423 
                 −0.40584943 
                 Kallikrein 10 
               
               
                 Q96KC3 
                 MGC3047 
                 NM_032348 
                 59384 
                 0.39922401 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 MGC3047 
               
               
                 O95274 
                 C4.4A 
                 NM_014400 
                 11950 
                 −0.39942513 
                 GPI-anchored 
               
               
                   
                   
                   
                   
                   
                 metastasis-associated 
               
               
                   
                   
                   
                   
                   
                 protein homolog 
               
               
                 HSAC015726 
                 SERPINB13 
                 AJ001696 
                 241407 
                 −0.41273549 
                 Serine (or cysteine) 
               
               
                   
                   
                   
                   
                   
                 proteinase inhibitor, 
               
               
                   
                   
                   
                   
                   
                 clade B (ovalbumin), 
               
               
                   
                   
                   
                   
                   
                 member 13 
               
               
                 SEN7_HUMAN 
                 SENP7 
                 AL136599 
                 30443 
                 −0.37916215 
                 Sentrin/SUMO-specific 
               
               
                   
                   
                   
                   
                   
                 protease 
               
               
                 HSAC015968 
                 RPL34P2 
                 AL049714 
                 247903 
                 −0.39984188 
                 Ribosomal protein L34 
               
               
                   
                   
                   
                   
                   
                 pseudogene 2 
               
               
                 IM8B_HUMAN 
                 TIMM8B 
                 NM_012459 
                 279915 
                 −0.39646264 
                 Translocase of inner 
               
               
                   
                   
                   
                   
                   
                 mitochondrial 
               
               
                   
                   
                   
                   
                   
                 membrane 8 homolog 
               
               
                   
                   
                   
                   
                   
                 B (yeast) 
               
               
                 P05209 
                 K-ALPHA-1 
                 NM_006082 
                 334842 
                 0.39265415 
                 Tubulin, alpha, 
               
               
                   
                   
                   
                   
                   
                 ubiquitous 
               
               
                 CYTB_HUMAN 
                 CSTB 
                 NM_000100 
                 695 
                 −0.39593616 
                 Cystatin B (stefin B) 
               
               
                 MMDP_HUMAN 
                 MMD 
                 NM_012329 
                 79889 
                 0.35585533 
                 Monocyte to 
               
               
                   
                   
                   
                   
                   
                 macrophage 
               
               
                   
                   
                   
                   
                   
                 differentiation- 
               
               
                   
                   
                   
                   
                   
                 associated 
               
               
                 Q9H5J1 
                 PREI3 
                 NM_015387 
                 107942 
                 −0.39957843 
                 Preimplantation protein 
               
               
                   
                   
                   
                   
                   
                 3 
               
               
                 Q9Y283 
                 INVS 
                 NM_014425 
                 104715 
                 0.38165914 
                 Inversin 
               
               
                 S107_HUMAN 
                 S100A7 
                 NM_002963 
                 112408 
                 −0.38002947 
                 S100 calcium binding 
               
               
                   
                   
                   
                   
                   
                 protein A7 (psoriasin 1) 
               
               
                 SR19_HUMAN 
                 SRP19 
                 NM_003135 
                 2943 
                 −0.39927981 
                 Signal recognition 
               
               
                   
                   
                   
                   
                   
                 particle 19 kD 
               
               
                 MA17_HUMAN 
                 DD96 
                 NM_005764 
                 271473 
                 −0.38289729 
                 Epithelial protein up- 
               
               
                   
                   
                   
                   
                   
                 regulated in carcinoma, 
               
               
                   
                   
                   
                   
                   
                 membrane associated 
               
               
                   
                   
                   
                   
                   
                 protein 17 
               
               
                 O75943 
                 RAD17 
                 NM_002873 
                 16184 
                 −0.38971266 
                 RAD17 homolog ( S.   
               
               
                   
                   
                   
                   
                   
                   pombe ) 
               
               
                 THA_HUMAN 
                 THRA 
                 NM_003250 
                 724 
                 0.38475204 
                 Thyroid hormone 
               
               
                   
                   
                   
                   
                   
                 receptor, alpha 
               
               
                   
                   
                   
                   
                   
                 (erythroblastic 
               
               
                   
                   
                   
                   
                   
                 leukemia viral (v-erb-a) 
               
               
                   
                   
                   
                   
                   
                 oncogene homolog, 
               
               
                   
                   
                   
                   
                   
                 avian) 
               
               
                 HSAC008967 
                 0 
                 AK021982 
                 287465 
                 0.38611307 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ11920 fis, clone 
               
               
                   
                   
                   
                   
                   
                 HEMBB1000312 
               
               
                 TFE2_HUMAN 
                 TCF3 
                 M31523 
                 101047 
                 0.38678059 
                 Transcription factor 3 
               
               
                   
                   
                   
                   
                   
                 (E2A immunoglobulin 
               
               
                   
                   
                   
                   
                   
                 enhancer binding 
               
               
                   
                   
                   
                   
                   
                 factors E12/E47) 
               
               
                 SUL2_HUMAN 
                 KIAA1247 
                 AB033073 
                 43857 
                 0.39182636 
                 Similar to glucosamine- 
               
               
                   
                   
                   
                   
                   
                 6-sulfatases 
               
               
                 HRA3_HUMAN 
                 HTRA3 
                 AY040094 
                 60440 
                 0.38043383 
                 Serine protease 
               
               
                   
                   
                   
                   
                   
                 HTRA3 
               
               
                 CN4A_HUMAN 
                 PDE4A 
                 NM_006202 
                 89901 
                 0.36750244 
                 Phosphodiesterase 4A, 
               
               
                   
                   
                   
                   
                   
                 cAMP-specific 
               
               
                   
                   
                   
                   
                   
                 (phosphodiesterase E2 
               
               
                   
                   
                   
                   
                   
                 dunce homolog, 
               
               
                   
                   
                   
                   
                   
                   Drosophila ) 
               
               
                 LTB2_HUMAN 
                 LTBP2 
                 NM_000428 
                 83337 
                 0.36424793 
                 Latent transforming 
               
               
                   
                   
                   
                   
                   
                 growth factor beta 
               
               
                   
                   
                   
                   
                   
                 binding protein 2 
               
               
                 CSF2_HUMAN 
                 CSF2 
                 NM_000758 
                 1349 
                 0.34759785 
                 Colony stimulating 
               
               
                   
                   
                   
                   
                   
                 factor 2 (granulocyte- 
               
               
                   
                   
                   
                   
                   
                 macrophage) 
               
               
                 S109_HUMAN 
                 S100A9 
                 NM_002965 
                 112405 
                 −0.38115533 
                 S100 calcium binding 
               
               
                   
                   
                   
                   
                   
                 protein A9 (calgranulin 
               
               
                   
                   
                   
                   
                   
                 B) 
               
               
                 MAL2_HUMAN 
                 MAL2 
                 NM_052886 
                 76550 
                 −0.37756452 
                 Mal, T-cell 
               
               
                   
                   
                   
                   
                   
                 differentiation protein 2 
               
               
                 HSAC004288 
                 LANO 
                 NM_018214 
                 35091 
                 −0.39020801 
                 LAP (leucine-rich 
               
               
                   
                   
                   
                   
                   
                 repeats and PDZ) and 
               
               
                   
                   
                   
                   
                   
                 no PDZ protein 
               
               
                 P05209 
                 K-ALPHA-1 
                 NM_006082 
                 334842 
                 0.37816007 
                 Tubulin, alpha, 
               
               
                   
                   
                   
                   
                   
                 ubiquitous 
               
               
                 EMP3_HUMAN 
                 EMP3 
                 NM_001425 
                 9999 
                 0.37961495 
                 Epithelial membrane 
               
               
                   
                   
                   
                   
                   
                 protein 3 
               
               
                 LUM_HUMAN 
                 LUM 
                 NM_002345 
                 79914 
                 0.36091717 
                 Lumican 
               
               
                 Q8NC43 
                 FLJ23091 
                 NM_024911 
                 250746 
                 0.4002659 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ23091 
               
               
                 HRA1_HUMAN 
                 PRSS11 
                 NM_002775 
                 75111 
                 0.38314991 
                 Protease, serine, 11 
               
               
                   
                   
                   
                   
                   
                 (IGF binding) 
               
               
                 CAH6_HUMAN 
                 CA6 
                 NM_001215 
                 100322 
                 0.38495881 
                 Carbonic anhydrase VI 
               
               
                 SCGF_HUMAN 
                 SCGF 
                 NM_002975 
                 105927 
                 0.38520465 
                 Stem cell growth factor; 
               
               
                   
                   
                   
                   
                   
                 lymphocyte secreted 
               
               
                   
                   
                   
                   
                   
                 C-type lectin 
               
               
                 CALD_HUMAN 
                 CALD1 
                 NM_033138 
                 325474 
                 0.36017333 
                 Caldesmon 1 
               
               
                 SYH_HUMAN 
                 HARS 
                 NM_002109 
                 77798 
                 0.34476889 
                 Histidyl-tRNA 
               
               
                   
                   
                   
                   
                   
                 synthetase 
               
               
                 Q8IXQ7 
                 LABH1 
                 NM_032604 
                 98608 
                 0.36012503 
                 Lung alpha/beta 
               
               
                   
                   
                   
                   
                   
                 hydrolase 1 
               
               
                 WEE1_HUMAN 
                 WEE1 
                 X62048 
                 75188 
                 −0.38967133 
                 WEE1+ homolog ( S.   
               
               
                   
                   
                   
                   
                   
                   pombe ) 
               
               
                 Q9H0B8 
                 DKFZP434B044 
                 NM_031476 
                 262958 
                 0.36902739 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 DKFZp434B044 
               
               
                 M1B1_HUMAN 
                 MAN1B1 
                 NM_016219 
                 279881 
                 0.37430439 
                 Mannosidase, alpha, 
               
               
                   
                   
                   
                   
                   
                 class 1B, member 1 
               
               
                 FBX8_HUMAN 
                 FBXO8 
                 NM_012180 
                 76917 
                 −0.37436238 
                 F-box only protein 8 
               
               
                 SM3C_HUMAN 
                 SEMA3C 
                 NM_006379 
                 171921 
                 0.35697551 
                 Sema domain, 
               
               
                   
                   
                   
                   
                   
                 immunoglobulin 
               
               
                   
                   
                   
                   
                   
                 domain (Ig), short basic 
               
               
                   
                   
                   
                   
                   
                 domain, secreted, 
               
               
                   
                   
                   
                   
                   
                 (semaphorin) 3C 
               
               
                 RB25_HUMAN 
                 CATX-8 
                 NM_020387 
                 150826 
                 −0.38816294 
                 CATX-8 protein 
               
               
                 ROL_HUMAN 
                 HNRPL 
                 NM_001533 
                 2730 
                 0.34146766 
                 Heterogeneous nuclear 
               
               
                   
                   
                   
                   
                   
                 ribonucleoprotein L 
               
               
                 FX37_HUMAN 
                 MGC11279 
                 NM_024326 
                 10915 
                 −0.38119046 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 MGC11279 
               
               
                 HSAC003262 
                 KIAA0350 
                 AB002348 
                 23263 
                 −0.39564135 
                 KIAA0350 protein 
               
               
                 P05209 
                 K-ALPHA-1 
                 NM_006082 
                 334842 
                 0.37391308 
                 Tubulin, alpha, 
               
               
                   
                   
                   
                   
                   
                 ubiquitous 
               
               
                 BTE4_HUMAN 
                 KLF16 
                 NM_031918 
                 303194 
                 0.40092333 
                 Kruppel-like factor 16 
               
               
                 MK_HUMAN 
                 MDK 
                 NM_002391 
                 82045 
                 −0.38900237 
                 Midkine (neurite 
               
               
                   
                   
                   
                   
                   
                 growth-promoting 
               
               
                   
                   
                   
                   
                   
                 factor 2) 
               
               
                 Q9NRD9 
                 DUOX1 
                 NM_017434 
                 272813 
                 −0.3913498 
                 Dual oxidase 1 
               
               
                 P05209 
                 K-ALPHA-1 
                 NM_006082 
                 334842 
                 0.36936704 
                 Tubulin, alpha, 
               
               
                   
                   
                   
                   
                   
                 ubiquitous 
               
               
                 Z185_HUMAN 
                 ZNF185 
                 NM_007150 
                 16622 
                 −0.36378851 
                 Zinc finger protein 185 
               
               
                   
                   
                   
                   
                   
                 (LIM domain) 
               
               
                 TBG2_HUMAN 
                 TUBG2 
                 NM_016437 
                 279669 
                 0.34203519 
                 Tubulin, gamma 2 
               
               
                 AAKC_HUMAN 
                 PRKAB2 
                 NM_005399 
                 50732 
                 −0.35738949 
                 Protein kinase, AMP- 
               
               
                   
                   
                   
                   
                   
                 activated, beta 2 non- 
               
               
                   
                   
                   
                   
                   
                 catalytic subunit 
               
               
                 HSAC006508 
                 COL18A1 
                 AF018081 
                 78409 
                 0.37705859 
                 Collagen, type XVIII, 
               
               
                   
                   
                   
                   
                   
                 alpha 1 
               
               
                 Q9BSY6 
                 ZD52F10 
                 NM_033317 
                 32343 
                 −0.37419257 
                 Hypothetical gene 
               
               
                   
                   
                   
                   
                   
                 ZD52F10 
               
               
                 SOX4_HUMAN 
                 0 
                 AJ420500 
                 351928 
                 −0.41521785 
                   Homo sapiens  mRNA 
               
               
                   
                   
                   
                   
                   
                 full length insert cDNA 
               
               
                   
                   
                   
                   
                   
                 clone EUROIMAGE 
               
               
                   
                   
                   
                   
                   
                 1977059 
               
               
                 P05209 
                 K-ALPHA-1 
                 NM_006082 
                 334842 
                 0.37198391 
                 Tubulin, alpha, 
               
               
                   
                   
                   
                   
                   
                 ubiquitous 
               
               
                 MIC2_HUMAN 
                 MIC2 
                 NM_002414 
                 177543 
                 0.36316608 
                 Antigen identified by 
               
               
                   
                   
                   
                   
                   
                 monoclonal antibodies 
               
               
                   
                   
                   
                   
                   
                 12E7, F21 and O13 
               
               
                 VWF_HUMAN 
                 VWF 
                 NM_000552 
                 110802 
                 −0.36187757 
                 Von Willebrand factor 
               
               
                 MFA5_HUMAN 
                 MAGP2 
                 NM_003480 
                 300946 
                 0.34145531 
                 Microfibril-associated 
               
               
                   
                   
                   
                   
                   
                 glycoprotein-2 
               
               
                 ELAF_HUMAN 
                 PI3 
                 NM_002638 
                 112341 
                 −0.39367703 
                 Protease inhibitor 3, 
               
               
                   
                   
                   
                   
                   
                 skin-derived (SKALP) 
               
               
                 WD13_HUMAN 
                 WDR13 
                 NM_017883 
                 12142 
                 0.35576479 
                 WD repeat domain 13 
               
               
                 PCB1_HUMAN 
                 PCBP1 
                 NM_006196 
                 2853 
                 −0.35199657 
                 Poly(rC) binding 
               
               
                   
                   
                   
                   
                   
                 protein 1 
               
               
                 DYHC_HUMAN 
                 DNCH1 
                 AB002323 
                 7720 
                 0.36908919 
                 Dynein, cytoplasmic, 
               
               
                   
                   
                   
                   
                   
                 heavy polypeptide 1 
               
               
                 Q8WUB2 
                 HSU79274 
                 NM_013300 
                 150555 
                 −0.41095099 
                 Protein predicted by 
               
               
                   
                   
                   
                   
                   
                 clone 23733 
               
               
                 Q96N74 
                 PGLYRP 
                 NM_052890 
                 282244 
                 −0.37818832 
                 Peptidoglycan 
               
               
                   
                   
                   
                   
                   
                 recognition protein L 
               
               
                   
                   
                   
                   
                   
                 precursor 
               
               
                 HSAC018816 
                 0 
                 AK055723 
                 310919 
                 −0.37825237 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ31161 fis, clone 
               
               
                   
                   
                   
                   
                   
                 KIDNE1000028 
               
               
                 PPL2_HUMAN 
                 PPIL2 
                 NM_014337 
                 93523 
                 −0.34926253 
                 Peptidylprolyl 
               
               
                   
                   
                   
                   
                   
                 isomerase 
               
               
                   
                   
                   
                   
                   
                 (cyclophilin)-like 2 
               
               
                 HSAC015090 
                 0 
                 AK055294 
                 211132 
                 0.34738745 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ30732 fis, clone 
               
               
                   
                   
                   
                   
                   
                 FEBRA2000126, 
               
               
                   
                   
                   
                   
                   
                 weakly similar to  Mus   
               
               
                   
                   
                   
                   
                   
                   musculus  PDZ domain 
               
               
                   
                   
                   
                   
                   
                 actin 
               
               
                 P05209 
                 K-ALPHA-1 
                 NM_006082 
                 334842 
                 0.36404497 
                 Tubulin, alpha, 
               
               
                   
                   
                   
                   
                   
                 ubiquitous 
               
               
                 DSG3_HUMAN 
                 DSG3 
                 NM_001944 
                 1925 
                 −0.35916779 
                 Desmoglein 3 
               
               
                   
                   
                   
                   
                   
                 (pemphigus vulgaris 
               
               
                   
                   
                   
                   
                   
                 antigen) 
               
               
                 CTGF_HUMAN 
                 CTGF 
                 NM_001901 
                 75511 
                 0.36449331 
                 Connective tissue 
               
               
                   
                   
                   
                   
                   
                 growth factor 
               
               
                 Q96BW1 
                 0 
                 AK056354 
                 91612 
                 0.34964326 
                   Homo sapiens , clone 
               
               
                   
                   
                   
                   
                   
                 MGC: 23937 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 3930177, 
               
               
                   
                   
                   
                   
                   
                 mRNA, complete cds 
               
               
                 P05209 
                 K-ALPHA-1 
                 NM_006082 
                 334842 
                 0.36440521 
                 Tubulin, alpha, 
               
               
                   
                   
                   
                   
                   
                 ubiquitous 
               
               
                 HSAC020349 
                 0 
                 BC014584 
                 348710 
                 0.33020586 
                   Homo sapiens , clone 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 4047062, 
               
               
                   
                   
                   
                   
                   
                 mRNA 
               
               
                 G3P2_HUMAN 
                 GAPD 
                 NM_002046 
                 169476 
                 0.36112372 
                 Glyceraldehyde-3- 
               
               
                   
                   
                   
                   
                   
                 phosphate 
               
               
                   
                   
                   
                   
                   
                 dehydrogenase 
               
               
                 DES1_HUMAN 
                 DESC1 
                 NM_014058 
                 201877 
                 −0.37199135 
                 DESC1 protein 
               
               
                 PAI2_HUMAN 
                 SERPINB2 
                 NM_002575 
                 75716 
                 −0.39418824 
                 Serine (or cysteine) 
               
               
                   
                   
                   
                   
                   
                 proteinase inhibitor, 
               
               
                   
                   
                   
                   
                   
                 clade B (ovalbumin), 
               
               
                   
                   
                   
                   
                   
                 member 2 
               
               
                 PYG2_HUMAN 
                 0 
                 BC006132 
                 172084 
                 0.36848424 
                   Homo sapiens , clone 
               
               
                   
                   
                   
                   
                   
                 IMAGE: 3627860, 
               
               
                   
                   
                   
                   
                   
                 mRNA, partial cds 
               
               
                 CA17_HUMAN 
                 COL7A1 
                 NM_000094 
                 1640 
                 0.35840992 
                 Collagen, type VII, 
               
               
                   
                   
                   
                   
                   
                 alpha 1 (epidermolysis 
               
               
                   
                   
                   
                   
                   
                 bullosa, dystrophic, 
               
               
                   
                   
                   
                   
                   
                 dominant and 
               
               
                   
                   
                   
                   
                   
                 recessive) 
               
               
                 Q8NG54 
                 FLJ21212 
                 NM_024642 
                 47099 
                 −0.35274616 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ21212 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
               
               
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 5 
               
             
             
               
                   
               
               
                 List of 61 genes with highest predictive value 
               
             
          
           
               
                   
                   
                   
                   
                 N+ 
                   
               
               
                 UniProt 
                 Gene_symbol 
                 GB_accession 
                 UniGene_ID 
                 correlation 
                 Gene 
               
               
                   
               
             
          
           
               
                 FSL1_HUMAN 
                 FSTL1 
                 NM_007085 
                 296267 
                 0.53452734 
                 Follistatin-like 1 
               
               
                 ER22_HUMAN 
                 KDELR2 
                 NM_006854 
                 118778 
                 0.52986731 
                 KDEL (Lys-Asp-Glu- 
               
               
                   
                   
                   
                   
                   
                 Leu) endoplasmic 
               
               
                   
                   
                   
                   
                   
                 reticulum protein 
               
               
                   
                   
                   
                   
                   
                 retention receptor 2 
               
               
                 PCO1_HUMAN 
                 PCOLCE 
                 NM_002593 
                 202097 
                 0.52672595 
                 Procollagen C- 
               
               
                   
                   
                   
                   
                   
                 endopeptidase 
               
               
                   
                   
                   
                   
                   
                 enhancer 
               
               
                 SPRC_HUMAN 
                 SPARC 
                 NM_003118 
                 111779 
                 0.51922531 
                 Secreted protein, 
               
               
                   
                   
                   
                   
                   
                 acidic, cysteine-rich 
               
               
                   
                   
                   
                   
                   
                 (osteonectin) 
               
               
                 NC5R_HUMAN 
                 DIA1 
                 NM_007326 
                 274464 
                 0.51482855 
                 Diaphorase (NADH) 
               
               
                   
                   
                   
                   
                   
                 (cytochrome b-5 
               
               
                   
                   
                   
                   
                   
                 reductase) 
               
               
                 HSAC009848 
                 ZFP93 
                 NM_004234 
                 298089 
                 0.50989391 
                 Zinc finger protein 93 
               
               
                   
                   
                   
                   
                   
                 homolog (mouse) 
               
               
                 Q14521 
                 LLGL2 
                 NM_004524 
                 3123 
                 −0.50695888 
                 Lethal giant larvae 
               
               
                   
                   
                   
                   
                   
                 homolog 2 
               
               
                   
                   
                   
                   
                   
                 ( Drosophila ) 
               
               
                 Q8N6P7 
                 IL22R 
                 NM_021258 
                 110915 
                 −0.49928496 
                 Interleukin 22 
               
               
                   
                   
                   
                   
                   
                 receptor 
               
               
                 LEG1_HUMAN 
                 LGALS1 
                 NM_002305 
                 227751 
                 0.48740219 
                 Lectin, galactoside- 
               
               
                   
                   
                   
                   
                   
                 binding, soluble, 1 
               
               
                   
                   
                   
                   
                   
                 (galectin 1) 
               
               
                 Q9BYD5 
                 LOC84518 
                 NM_032488 
                 148590 
                 −0.48449285 
                 Protein related with 
               
               
                   
                   
                   
                   
                   
                 psoriasis 
               
               
                 CQT6_HUMAN 
                 CTRP6 
                 NM_031910 
                 22011 
                 0.47978614 
                 Complement-c1q 
               
               
                   
                   
                   
                   
                   
                 tumor necrosis factor- 
               
               
                   
                   
                   
                   
                   
                 related protein 6 
               
               
                 AD12_HUMAN 
                 ADAM12 
                 NM_003474 
                 8850 
                 0.47905457 
                 A disintegrin and 
               
               
                   
                   
                   
                   
                   
                 metalloproteinase 
               
               
                   
                   
                   
                   
                   
                 domain 12 (meltrin 
               
               
                   
                   
                   
                   
                   
                 alpha) 
               
               
                 Q8N3N2 
                 FLJ11196 
                 NM_018357 
                 6166 
                 0.47772636 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ11196 
               
               
                 Q96DR2 
                   
                 AK055031 
                 44289 
                 −0.47659518 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ30469 fis, clone 
               
               
                   
                   
                   
                   
                   
                 BRAWH1000037, 
               
               
                   
                   
                   
                   
                   
                 weakly similar to 
               
               
                   
                   
                   
                   
                   
                 UROKINASE 
               
               
                   
                   
                   
                   
                   
                 PLASMINOGEN 
               
               
                   
                   
                   
                   
                   
                 ACTIVATO 
               
               
                 P03996 
                 ACTA2 
                 NM_001613 
                 195851 
                 0.47560995 
                 Actin, alpha 2, 
               
               
                   
                   
                   
                   
                   
                 smooth muscle, aorta 
               
               
                 K6A2_HUMAN 
                   
                 AK027727 
                 184581 
                 0.47396182 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ14821 fis, clone 
               
               
                   
                   
                   
                   
                   
                 OVARC1000556, 
               
               
                   
                   
                   
                   
                   
                 highly similar to 
               
               
                   
                   
                   
                   
                   
                 RIBOSOMAL 
               
               
                   
                   
                   
                   
                   
                 PROTEIN S6 
               
               
                   
                   
                   
                   
                   
                 KINASE II 
               
               
                 TM29_HUMAN 
                 TRIM29 
                 NM_012101 
                 82237 
                 −0.47250994 
                 Tripartite motif- 
               
               
                   
                   
                   
                   
                   
                 containing 29 
               
               
                 TIM2_HUMAN 
                   
                 AL110197 
                 6441 
                 0.47199573 
                 
                   Homo sapiens 
                 
               
               
                   
                   
                   
                   
                   
                 mRNA; cDNA 
               
               
                   
                   
                   
                   
                   
                 DKFZp586J021 (from 
               
               
                   
                   
                   
                   
                   
                 clone 
               
               
                   
                   
                   
                   
                   
                 DKFZp586J021) 
               
               
                 MCA2_HUMAN 
                 JTV1 
                 NM_006303 
                 301613 
                 0.46964142 
                 JTV1 gene 
               
               
                 OPN3_HUMAN 
                 OPN3 
                 NM_014322 
                 279926 
                 0.46101056 
                 Opsin 3 
               
               
                   
                   
                   
                   
                   
                 (encephalopsin, 
               
               
                   
                   
                   
                   
                   
                 panopsin) 
               
               
                 Q9UBG0 
                 KIAA0709 
                 NM_006039 
                 7835 
                 0.46012143 
                 Endocytic receptor 
               
               
                   
                   
                   
                   
                   
                 (macrophage 
               
               
                   
                   
                   
                   
                   
                 mannose receptor 
               
               
                   
                   
                   
                   
                   
                 family) 
               
               
                 TPM2_HUMAN 
                 TPM2 
                 NM_003289 
                 300772 
                 0.46003075 
                 Tropomyosin 2 (beta) 
               
               
                 INVO_HUMAN 
                 IVL 
                 NM_005547 
                 157091 
                 −0.45860578 
                 Involucrin 
               
               
                 PEPL_HUMAN 
                 PPL 
                 NM_002705 
                 74304 
                 −0.44874989 
                 Periplakin 
               
               
                 HSAC002603 
                 FLJ11036 
                 NM_018306 
                 16740 
                 −0.44841185 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ11036 
               
               
                 TNR5_HUMAN 
                 TNFRSF5 
                 NM_001250 
                 25648 
                 −0.44547341 
                 Tumor necrosis factor 
               
               
                   
                   
                   
                   
                   
                 receptor superfamily, 
               
               
                   
                   
                   
                   
                   
                 member 5 
               
               
                 FRIH_HUMAN 
                 FTH1 
                 AK054816 
                 62954 
                 0.4396982 
                 Ferritin, heavy 
               
               
                   
                   
                   
                   
                   
                 polypeptide 1 
               
               
                 P4H2_HUMAN 
                 P4HA2 
                 NM_004199 
                 3622 
                 0.42478412 
                 Procollagen-proline, 
               
               
                   
                   
                   
                   
                   
                 2-oxoglutarate 4- 
               
               
                   
                   
                   
                   
                   
                 dioxygenase (proline 
               
               
                   
                   
                   
                   
                   
                 4-hydroxylase), alpha 
               
               
                   
                   
                   
                   
                   
                 polypeptide II 
               
               
                 PS23_HUMAN 
                 SPUVE 
                 NM_007173 
                 25338 
                 0.42080095 
                 Protease, serine, 23 
               
               
                 HSAC011159 
                   
                 AF009267 
                 102238 
                 −0.46560322 
                   Homo sapiens  clone 
               
               
                   
                   
                   
                   
                   
                 FBA1 Cri-du-chat 
               
               
                   
                   
                   
                   
                   
                 region mRNA 
               
               
                 HSAC013320 
                   
                 AL162069 
                 140978 
                 −0.44362782 
                 
                   Homo sapiens 
                 
               
               
                   
                   
                   
                   
                   
                 mRNA; cDNA 
               
               
                   
                   
                   
                   
                   
                 DKFZp762H106 
               
               
                   
                   
                   
                   
                   
                 (from clone 
               
               
                   
                   
                   
                   
                   
                 DKFZp762H106) 
               
               
                 Q8N789 
                 DKFZP434K0410 
                 AL137589 
                 152149 
                 −0.43787021 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 DKFZp434K0410 
               
               
                 O60335 
                 KIAA0594 
                 AB011166 
                 103283 
                 −0.42578156 
                 KIAA0594 protein 
               
               
                 TCOF_HUMAN 
                 TCOF1 
                 NM_000356 
                 301266 
                 0.38956707 
                 Treacher Collins- 
               
               
                   
                   
                   
                   
                   
                 Franceschetti 
               
               
                   
                   
                   
                   
                   
                 syndrome 1 
               
               
                 O14635 
                   
                 AF005082 
                 113261 
                 −0.45637623 
                   Homo sapiens  skin- 
               
               
                   
                   
                   
                   
                   
                 specific protein 
               
               
                   
                   
                   
                   
                   
                 (xp33) mRNA, partial 
               
               
                   
                   
                   
                   
                   
                 cds 
               
               
                 GLSK_HUMAN 
                 GLS 
                 NM_014905 
                 239189 
                 0.43214995 
                 Glutaminase 
               
               
                 Q9BRJ6 
                 MGC11257 
                 NM_D32350 
                 334368 
                 0.42954566 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 MGC11257 
               
               
                 AQP3_HUMAN 
                 AQP3 
                 NM_004925 
                 234642 
                 −0.42891866 
                 Aquaporin 3 
               
               
                 SPIB_HUMAN 
                 SPIB 
                 NM_003121 
                 192861 
                 −0.41021146 
                 Spi-B transcription 
               
               
                   
                   
                   
                   
                   
                 factor (Spi-1/PU.1 
               
               
                   
                   
                   
                   
                   
                 related) 
               
               
                 DRG1_HUMAN 
                 DRG1 
                 NM_004147 
                 115242 
                 0.41879372 
                 Developmentally 
               
               
                   
                   
                   
                   
                   
                 regulated GTP 
               
               
                   
                   
                   
                   
                   
                 binding protein 1 
               
               
                 PHMX_HUMAN 
                 PHEMX 
                 NM_005705 
                 271954 
                 0.38728757 
                 Pan-hematopoietic 
               
               
                   
                   
                   
                   
                   
                 expression 
               
               
                 HSAC018335 
                   
                 AL137428 
                 306459 
                 −0.45404252 
                 
                   Homo sapiens 
                 
               
               
                   
                   
                   
                   
                   
                 mRNA; cDNA 
               
               
                   
                   
                   
                   
                   
                 DKFZp761N1323 
               
               
                   
                   
                   
                   
                   
                 (from clone 
               
               
                   
                   
                   
                   
                   
                 DKFZp761N1323) 
               
               
                 POSN_HUMAN 
                 OSF-2 
                 NM_006475 
                 136348 
                 0.42814786 
                 Osteoblast specific 
               
               
                   
                   
                   
                   
                   
                 factor 2 (fasciclin I- 
               
               
                   
                   
                   
                   
                   
                 like) 
               
               
                 DHC3_HUMAN 
                 CBR3 
                 NM_001236 
                 154510 
                 −0.48089013 
                 Carbonyl reductase 3 
               
               
                 HSAC015262 
                   
                 AK021531 
                 224398 
                 0.43632187 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ11469 fis, clone 
               
               
                   
                   
                   
                   
                   
                 HEMBA1001658 
               
               
                 Q14113 
                 AEBP1 
                 NM_001129 
                 118397 
                 0.42087649 
                 AE binding protein 1 
               
               
                 CRF_HUMAN 
                 CRH 
                 NM_000756 
                 75294 
                 −0.41353804 
                 Corticotropin 
               
               
                   
                   
                   
                   
                   
                 releasing hormone 
               
               
                 Q9NUJ7 
                 FLJ11323 
                 NM_018390 
                 25625 
                 −0.43842923 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ11323 
               
               
                 Q96DU1 
                 AKAP2 
                 AJ303079 
                 42322 
                 −0.44106809 
                 A kinase (PRKA) 
               
               
                   
                   
                   
                   
                   
                 anchor protein 2 
               
               
                 Q969Y7 
                 MGC4677 
                 NM_052871 
                 337986 
                 0.39455354 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 MGC4677 
               
               
                 Q9BXY6 
                 FLJ13962 
                 NM_024862 
                 330407 
                 −0.44327759 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ13962 
               
               
                 K1CW_HUMAN 
                 HAIK1 
                 NM_015515 
                 9029 
                 −0.42594883 
                 Type I intermediate 
               
               
                   
                   
                   
                   
                   
                 filament cytokeratin 
               
               
                 HSAC019114 
                 FLJ22622 
                 NM_025151 
                 324841 
                 −0.4331912 
                 Hypothetical protein 
               
               
                   
                   
                   
                   
                   
                 FLJ22622 
               
               
                 PGS2_HUMAN 
                 DCN 
                 NM_001920 
                 76152 
                 0.39882715 
                 Decorin 
               
               
                 DCOP_HUMAN 
                 ODC-p 
                 NM_052998 
                 91681 
                 −0.41609162 
                 Ornithine 
               
               
                   
                   
                   
                   
                   
                 decarboxylase-like 
               
               
                   
                   
                   
                   
                   
                 protein 
               
               
                 HSAC020747 
                 0 
                 AK056828 
                 350748 
                 −0.40822563 
                   Homo sapiens  cDNA 
               
               
                   
                   
                   
                   
                   
                 FLJ32266 fis, clone 
               
               
                   
                   
                   
                   
                   
                 PROST1000419 
               
               
                 Q96F00 
                 0 
                 AK025719 
                 251664 
                 0.39457176 
                   Homo sapiens  cDNA: 
               
               
                   
                   
                   
                   
                   
                 FLJ22066 fis, clone 
               
               
                   
                   
                   
                   
                   
                 HEP10611 
               
               
                 ISK5_HUMAN 
                 SPINK5 
                 NM_006846 
                 331555 
                 −0.43770884 
                 Serine protease 
               
               
                   
                   
                   
                   
                   
                 inhibitor, Kazal type, 
               
               
                   
                   
                   
                   
                   
                 5 
               
               
                 GFR1_HUMAN 
                 GFRA1 
                 NM_005264 
                 105445 
                 0.37859516 
                 GDNF family receptor 
               
               
                   
                   
                   
                   
                   
                 alpha 1 
               
               
                 AAF24516 
                 NUDEL 
                 NM_030808 
                 3850 
                 −0.40726277 
                 LIS1-interacting 
               
               
                   
                   
                   
                   
                   
                 protein NUDEL; 
               
               
                   
                   
                   
                   
                   
                 endooligopeptidase A 
               
               
                 O60836 
                 T1A-2 
                 NM_013317 
                 135150 
                 0.37127534 
                 Lung type-I cell 
               
               
                   
                   
                   
                   
                   
                 membrane- 
               
               
                   
                   
                   
                   
                   
                 associated 
               
               
                   
                   
                   
                   
                   
                 glycoprotein 
               
               
                 KLKA_HUMAN 
                 KLK10 
                 NM_002776 
                 69423 
                 −0.40584943 
                 Kallikrein 10