Abstract:
Preparation of an orally administrable pharmaceutical composition containing traditional Chinese medicine for hematologic diseases is disclosed. The pharmaceutical composition is for immunotherapy and is made from natural, non-toxic medicinal materials through extraction and other preparing processes. The pharmaceutical composition is helpful to prevent, mitigate and cure cancers.

Description:
BACKGROUND OF THE INVENTION 
       [0001]    1. Technical Field 
         [0002]    The present invention relates to relates to pharmaceutical compositions for treating hematologic diseases, including hematologic cancers, and more particularly to a method for preparing pharmaceutical compositions for immunotherapy from natural medicinal materials. The disclosed method involves processing the natural medicinal materials according to their respective properties, so as to obtain the best effects on preventing, mitigating and curing hematologic diseases. 
         [0003]    2. Description of Related Art 
         [0004]    Cancers are diseases incurred by abnormal control mechanism for cell division and cell proliferation. Virtually all kinds of cells have the possibility to become tumor cells. However, most human cancers associate with malignant tumors of epithelial cells. This type covers the majority of cancers, and some of them are common cancers, such as breast cancer, prostate cancer and lung cancer. The known malignant epithelial cell tumors can be categorized into malignant squamous epithelial cell tumors (turned from normal epithelial cells) and malignant adenoma. 
         [0005]    For controlling cancers, the currently employed therapies are surgical removal, chemotherapy, radiotherapy, immunotherapy and passive immunotherapy, among others. The determination of therapies depends on the tumor positions, malignant levels, evolution and patients&#39; conditions. Some experimental therapies have been also developed for cancers. The aim is to find cancer treatments that can completely eliminate cancer cells while forming no harm to healthy calls. Surgical removal is only effective when there are no spreading or remote metastases. Chemotherapy is not a perfect solution as it is also toxic to the non-targeted cells. Radiotherapy has the same problem. Briefly, cancers represent various tumors in different kinds of cells, and there is not a “single cure” for all of them. Conventionally, the aforementioned therapies are implemented alternatively or simultaneously according to the progress of the cancers to be treated for optimizing the curative effects. However, removal, chemotherapy and radiotherapy are particularly burdens to a patient&#39;s weak body. Moreover, once the metastases happen, it will be difficult to control the progress with any of the known therapies. For all these reasons, how to treat cancers is still a big challenge to the human. 
         [0006]    Immunity protects our health and it is activated by leukocytes. In other words, leukocytes are soldiers fighting invaders for us. There are three kinds of leukocytes: 
         [0007]    (1) Lymphocytes: It&#39;s lymphocytes main duty to identify enemies and call immunocytes to attack the abnormal cells. 
         [0008]    (2) Macrophages: they eat any bacteria and abnormal cells upon detection. 
         [0009]    (3) Granulocyte: granulocytes are also referred to as phagocytic cells, serving to expel bacteria and abnormal cells. 
         [0010]    When lymphocytes, macrophages and granulocyte work together, they can have pathogens and unwanted old cells removed from human body. However, tumor cells and virus-infected cells are not foreign invaders, but our own cells. This prevents our immune system from properly identifying the targets. Thus, it is critical to have our immunocytes activated. 
         [0011]    Immune system has three main functions: 
         [0012]    (1) Guarding from microbial infection: when body cells are invaded, it can expel the infective source and control the infection. 
         [0013]    (2) Rejecting cells from other individuals: it produces antibodies after blood transfusion or organ transplantation to reject the foreign cells. 
         [0014]    (3) Removing mutated cells and old tissues: when finding trouble cells or unwanted, old cells, it removes them by phagocytosis. 
         [0015]    In addition to proper treatments using surgical removal, chemotherapy and radiotherapy, it is important for a patient having a cancer to improve his/her immunity. This may be achieved by ingesting good food, having good lifestyle, and supplementing nutrition that helps to activate lymphocytes, namely B cells, T cells, and NK cells. 
         [0016]    There are thousands cancer cells generated in human body. Immune system keeps monitoring through blood circulation, and once finding cancer cells, it attacks. However, cancer cells are extremely tenacious and cunning They will fight back whenever immunologic inadequacy happens. Immunologic inadequacy means that various immunocytes such as T cells, B cells and NK cells are less active. If the inadequate immunity is not recovered in time to call the immunocytes to fight back, cancers will unavoidably happen. 
         [0017]    The principle of immunotherapy for treating cancers is to strengthen our immune system so as to clean all the pathogens, old cells, cancer cells, and virus-infected cells. Immunotherapy has proven to provide good curative effects on maintaining health, curing diseases, and providing nourishment during convalescence, and is known as effective to various diseases, from cough and colds to AIDS and cancers. We can say as long as good immunity is maintained well, the body can cure diseases by itself. 
         [0018]    In this regard, regularly taking health supplement products is an effective way. There are many immunity-strengthening products in the forms of orally administrable pharmaceutical compositions available on the market. The active ingredients are digested by macrophages in the small intestines, and act on receptors of cell membrane of most human cells, so as to make some actions taking place in cell nucleus stronger, thereby activating immunocytes. 
       SUMMARY OF THE INVENTION 
       [0019]    The present invention is an application of cancer immunotherapy. By strengthening the activity of autoimmune cells, the autoimmune functionality can identify and clean cancer cells, thereby maintaining health. 
         [0020]    The present invention involves selecting natural medicinal materials, immersing the materials with the presence of base liquor or honey, processing the soaks according to the properties of the respective materials, performing extraction, concentration and other processes, so as to produce orally administrable pharmaceutical compositions having preventing, mitigating and curing effects on hematologic diseases. 
     
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         [0021]      FIG. 1  is a flowchart of the method of the present invention. 
           [0022]      FIG. 2  illustrates the mechanism of the present invention. 
       
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
       [0023]    The invention as well as a preferred mode of use, further objectives and advantages thereof will be best understood by reference to the following detailed description of illustrative embodiments when read in conjunction with the accompanying drawings. 
         [0024]      FIG. 1  is a flowchart of the method of the present invention. As shown, selected medicinal materials  10  are first processed by stir-frying  14  and other primary processing processes according to their respective properties, so as to release the active ingredients from the medicinal materials  10 . In this step, the medicinal materials that have toxic side effects are reduced in terms of toxicity. The medicinal materials  10  then receive immersion  20  separately under different conditions determined according to their respective properties, so as to further release active substances. As disagglomeration happens in the soak of the immersion  20 , each of the medicinal materials  10  has its ingredients balanced by the fermentable substances of the base liquor used in the immersion  20 . Then some adjuvants are added into the soaks of the medicinal materials  10  after the immersion  20 . The soaks then receive extraction  30 , which extracts more active substances from the medicinal materials  10 , and chelates the medicinal materials  10  at different temperatures, thereby further enhancing the effects of the extracted substances and obtaining botanical extracts that are nutrimental, gentle, non-toxic and effective. In this manner, each of the medicinal materials  10  is processed to give out its most valuable essentials that are helpful to improve immunity, to enhance health and to cure diseases. The extracts obtained after the extraction  30  are then mixed in a predetermined ratio into a mixture. The mixture receives concentration  40  and forms a concentrate. After filling  41  and sterilization  50 , the product  60 , or the pharmaceutical composition, is ready to serve. 
         [0025]    In the present invention, the selected medicinal materials  10  are processed by stir-frying  14  and other primary processing processes so that the medicinal materials  10  can have their active ingredients released completely, and this helps to reduce amount of the toxic medicinal materials that have toxic side effects. Therein, stir-frying  14  is applied to  Semiaquilegia adoxoides (DC.) makino.  This process promotes synergism between the medical materials, enhances the curative and detoxifying effects, and modulates the performance of the medical materials. The substance so obtained thus is useful for remedium corrigents, thereby contributing to relieving cough and asthma, and reinforcing the spleen to benefit the qi. The medicinal materials  10  are processed separately during the primary processing stage, and then receive different process of immersion  20 . The immersion  20  includes immersion  21  for  Baphicacanthus cusia  (Nees)  Bremek  (Natural Indigo), immersion  22  for  Mucuna macrocarpa Wallich,  immersion  23  for  Solanum lyratumThunb  (BittersweetHerb) and immersion  24  for  Semiaquilegia adoxoides (DC.) makino.  A base liquor is used in each said immersion so as to make the medicinal materials  10  release their active substances. The consequent disagglomeration allows the medicinal materials  10  to be sufficiently affected by the fermentable substances in the base liquor and present the most balanced effects. 
         [0026]    After the immersion  20 , the soaks of the medicinal materials  10  are put into the process of extraction  30 . Particularly, among the extraction  30 , extraction  31  has  Glehnia littoralis Fr:Schmidt ex Miq  added, extraction  32  has  Hedyotis diffusa  added, extraction  33  has  Pseudobulb of Appendiculate Cremastra  added, and extraction  34  has  Parispolyphylla Smith varchinensis (Franch.) Hara  added. Thereby, more effective substances can be extracted from the medicinal materials  10 , and the medicinal materials  10  are chelated at different temperatures, thereby further enhancing the effects of the extracted substances and obtaining botanical extracts that are nutrimental, gentle, non-toxic and effective. In this manner, each of the medicinal materials  10  is processed to give out its most valuable essentials that are helpful to improve immunity, to enhance health and to cure diseases. 
         [0027]    The extracts obtained after the extraction  30  are then mixed in a predetermined ratio into a mixture, or mixed in different ratios into various mixtures. The mixtures receive concentration  40  and form concentrates. After filling  41  and sterilization  50 , the products  60 , or the pharmaceutical compositions, are ready to serve for meeting different needs. 
         [0028]    As described previously, in one embodiment, the product  60  of the made of the medicinal materials  10  including  Parispolyphylla Smith varchinensis (Franch.) Hara, Hedyotis diffusa  (white flower snake-tongue grass),  Mucuna macrocarpa Wallich, Pseudobulb of Appendiculate Cremastra, Solanum lyratumThunb  (BittersweetHerb),  Glehnia littoralis Fr.Schmidt ex Miq, Semiaquilegia adoxoides  (DC.) makino.,  and  Baphicacanthus cusia  (Nees)  Bremek.  (Natural Indigo) as the main ingredients thereof. The product  60  has been proven to be curatively effective to all hematologic cancers, such as leukemia, primary brain tumors, osteocarcinoma, and prostate cancer. 
         [0029]      FIG. 2  illustrates the mechanism of the present invention. In use, the inventive product  60  has its active ingredients carried by rhodocytes  71  circulated in human blood  70 , thereby helping leukocytes  72  to improve the performance of body apparatuses  80 . Also, rhodocytes  71  can carry hydrophilic active molecules to make them attach to the surfaces of T cells  81 . As a result, the active molecules in the pharmaceutical composition can activate the T cells  81 , to generate activated T cells  82 . Meanwhile, T cell&#39;s receptor  83  and the major histocompatibility complex  84  and the antigen  85  act on the antigen presenting cells  90 , so as to make the antigen-presenting cell precursors  91  and tumor antigen-related cytokines  92  change. The activated T cells  82  can secrete cytokines and generate cytotoxic T cells  86  that attack tumor cells  93 . Further, granzyme acts to break the tumor cells  93 , forming disagglomerated tumor cells  94 . Thereby, the inventive product  60  is useful to improve human immunity. When taken into body by the macrophages of the small intestines, it presents powerful catalyzing effects on the receptors of the membrane of most human cells, so as to make some actions taking place in cell nucleus stronger, thereby accomplishing immunotherapy. (See Appendix I, FR-AC00384 Rat Orally Administrated Acute Toxicity Test CHSG-608, and Appendix II FR-SC00031-Final Rat 13-Week Appendix Repeated Dose (Subchronic) Toxicity Test CHSG-608). 
         [0030]    To sum up, the present invention is accomplished by selecting various natural medicinal materials and implementing immersion, extraction, concentration, and other processes, so as to prepare pharmaceutical products for different immunotherapy-related treatments, thereby preventing, mitigating and curing hematologic diseases. The present invention has been described with reference to the preferred embodiments and it is understood that the embodiments are not intended to limit the scope of the present invention. Moreover, as the contents disclosed herein should be readily understood and can be implemented by a person skilled in the art, all equivalent changes or modifications which do not depart from the concept of the present invention should be encompassed by the appended claims.