Abstract:
The present invention provides a process for characterizing a glatiramer acetate related drug substance or drug product comprising the steps of:
   a) obtaining a batch of the glatiramer acetate related drug substance or drug product;   b) contacting mammalian cells with an amount of the glatiramer acetate related drug substance or drug product of step a); and   c) i) determining the level of expression of at least one gene selected from the group consisting of ABCF2, ABI2, ACP6, AFG3L2, ALMS1, ARPC4, CALM3, CCDC64, CD84, CDC6, CHAF1A, CLU, COX11, DLGAP1, DTX4, FAM49B, FHL1, FNTB, GYPC, HFE, IL10, LPHN1, NACA, OLAH, PATZ1, PDK1, POLI, REEP5, RPL5, RPS6KA2, SEC31A, SETBP1, SNRPA1, SYNCRIP, TNFSF9, TOMM40, TPM1, TSHZ1, TSPAN13, UBAP2, VAV3, VDAC2, and ZFAND6; ii) determining the level of expression of at least one gene selected from the group consisting of BIRC3, CCL24, CCR1, CISH, CSF1R, CX3CR1, CXCL10, HSPD1, ICAM1, IL1B, IFNGR1, IL27, IL2RG, IL7R, IL1RN, MMP1, MMP9, MMP14, PGRMC1, PRDM1, CARD15, CCL2, CCL5, CD14, IL10, THBD, and NFKBIA, wherein if IL1B, IL10, or MMP9 is the at least one gene selected in part (c)(ii), then selecting at least a second different gene from the group other than IL1B, IL10, or MMP9; iii) determining the level of expression of at least one gene selected from the group consisting of C13ORF31, C14ORF10, C1ORF51, C1ORF63, CBR4, CB36, CD9, COL6A1, DAB2, GATA2, KIAA0907, LOC100506233, MCM6, MMP1, MS4A4A, MTSS1, PCMTD1, STK4, STX7, TAF15, TARP, TIA1, TMF1, TRGC2, TXNDC11, and ZCCHC7, and ZCCHC7; iv) determining the level of expression of at least one gene selected from the group consisting of ANXA1, ARRB2, BEAN, BIN1, C1ORF63, CD44, CD9, CFP, COL6A1, CRIP2, EPB41, Fam119a, FGR, FOX03B, HSD11B1, HSPD1P6, LOC387790, MPEG1, MYB, OLIG1, PLD1, PPP4R2, PRDM1, RBM6, SNX27, 5OD2, STATH, TARP, TREM1, TRGC2, UBN2, and ZCCHC7; v) determining the level of expression of at least one gene selected from the group consisting of ADAM9, ADAMDEC1, AKR1C2, ANXA2, ANXA2P2, ARHGAP18, ARHGAP18, ARL6IP5, ARL6IP5, ATP2C1, BID, BIRC3, BTG1, CARD15, C1ORF21, C13ORF31, C5ORF13, C5ORF32, C9ORF130, CAST, CCL2, CCL5, CD14, CD300A, CD36, CD40, CD55, CD9, CENTA2, CHST11, COL6A1, CRYBB2, CXCL10, CYLD, DAB2, EBI3, EBI2, ECOP, EGF, FABP4, FXYD2, GHRL, GIMAP8, GLIPR1, G0S2, HMGB2, HNRPLL, ICAM1, ICAM2, IFIH1, IFNGR1, IL10, MORA, IL4I1, INADL, ISG20, ITGB5, KIAA1505, KYNU, LACTB, L0054103, LOC388344, LOC652751, LPAAT-THETA, LPXN, MAFB, MALT1, MFI2, MGC5618, MGLL, MITF, MLF1, MMPI, MMP9, MPEG1, MTSS1, MXD1, NT5E, NFKBIE, NFKBIA, NFE2L3, NFE2L3, OSBPL11, P2RX4, P2RY5, PLEKHO1, POPDC3, PLAUR, PRDM1, PSCDBP, PTX3, RAB27B, RCSD1, RPL13, SGIP1, SLC39A8, SNORD68, SRPX2, SRA1, SLIC1, SLAMF8, SLIC1, SOD2, STATH, STEAP1, SYNJ2, SYNJ2, TATDN3, TGM5, THBD, TNFAIP3, TNFAIP6, TNFRSF9, TNFSF13B, TPSAB1, TPSB2, TREM1, TXNL2, VPS33A, and VSNL1; vi) determining the level of expression of at least one gene selected from the group consisting of ACTN4, BTBD14A, C14ORF10, CISH, CLK1, CRLF3, FAM62A, FBX045, GAPDHS, HDAC4, HIC2, HNRPD, HSPD1, LOC648342, MYB, NAPB, OXCT2, SERPINB2, SFRS14, SPFH1, STT3B, WDFY1, ZNF250, and ZNF566; vii) determining the level of expression of at least one gene selected from the group consisting of A2M, ABCB1, ABCC3, ABHD2, ACPP, ADAMDEC1, ADFP, ADORA2B, ADORA3, AHNAK, ALCAM, ANKH, ANKRD57, ANXA2, ANXA2P2, APBB1IP, AQP1, ARHGAP18, ARHGAP20, ARHGEF3, ARID5B, ARMC9, ATF5, ATP1B1, ATP6V0D2, ATP9A, ATP10A, AYTL1, BCL2A1, BCL6, C3AR1, C13ORD31, C9ORF88, C9ORF89, C1ORF21, C1ORF21, C10ORF95, C13ORF31, C21ORF7, CARD12, CARD15, CCDC83, CCL5, CCL24, CCND1, CCR1, CD9, CD36, CD52, CD86, CD109, CD180, CD244, CDK5RAP2, CDKN1A, CENTA2, CKB, CKLF, CLEC7A, CNIH3, COL6A1, COL22A1, CRIP2, CSF1R, CSPG4, CTSL, CTSLL3, CX3CR1, CXCR7, CYBB, CYP1B1, DAB2, DAPP1, DDIT4L, DIXDC1, DOCK4, DOK2, DKFZP56400823, DKFZP686O1327, EBI2, EMP1, EMR2, ENPP2, EPAS1, EPS8, EPSTI1, EVL, FABP4, FADS3, FAM26B, FGD2, FGD2, FGD4, FGL2, FN1, FTH1, GBP2, GBP3, GBP5, GCNT1, GDPD1, GNDL, GNLY, GLIPR1, GLIS3, GPC1, GPR35, H2A/R, HAVCR2, HMCN1, HIPK2, HIST2H2AA, HIVEP1, HMOX1, HSPB7, ICAM1, ID2, ID2B, IFI30, IFI44, IFNGR1, IGFBP3, IL2RG, IL4I1, IL1ORA, IL27RA, IL7R, IL10, INA, IRF7, ITGB5, ITGB7, KIAA1505, KIAA1706, KMO, LBH, LFNG, LILRB1, LILRB2, LMNA, L0051334, LOC201895, LOC284262, L0051334, LOC643424, LOC643834, LOC643847, LOC644242, LOC645238, LOC650429, LOC650446, LOC652543, LOC653610, LOC653754, LPAAT-THETA, LPXN, MAF, MAFB, MAML2, MAML3, MARCH1, MCOLN3, MDGA1, ME1, MFI1, MFI2, MGC45491, MGLL, MITF, MMP1, MMP2, MMP9, MMP14, MMP19, MTMR11, MTSS1, MTSUl, NGEF, NME7, NPTX1, NRCAM, NRP1, NRP2, NT5E, OAS1, OLR1, P2RY5, P2RY14, PALLD, PAPSS2, PAQR5, PCDHGA1, PCDHGA2, PCDHGA3, PCDHGA4, PCDHGA5, PCDHGA6, PCDHGA7, PCDHGA8, PCDHGA9, PCDHGA10, PCDHGA11, PCDHGA12, PCDHGB1, PCDHGB2, PCDHGB3, PCDHGB4, PCDHGB5, PCDHGB7, PCDHGC3, PCDHGC4, PCDHGC5, PDK4, PDLIM7, PFKFB4, PGA5, PDLIM4, PHLDA1, PLA2G4A, PLEKHA7, PLEKHO1, POPDC3, PRDM1, PRSS23, PSCDBP, PSD3, PTAFR, PTGS1, PTPRO, PTRF, PTX3, RAB27B, RAB38, RAB7B, RAPH1, RASGRF1, RGL1, RGS13, RHBDF1, RIN2, S100A2, SART2, SERPINE2, SERTAD1, SETBP1, SGIP1, SH3TC1, SKIL, SLA, SLAMF7, SLAMF8, SLC6AS, SLC7A11, SLC12A6, SLC37A2, SLC41A2, SLC38A6, SLC43A2, SNAI3, ST3GAL5, STATH, STEAP1, SUCNR1, SYTL1, TBXAS1, TCF4, TFAP2A, THBD, TLR4, TM7SF4, TMEM39A, TMEM158, TNCRNA, TNFSF13B, TNFRSF21, TREM1, TRIM22, TRPA1, TRPM8, TRPS1, TUBB2A, UBXD5, UGCG, UPP1, VASH1, VEGF, VSNL1, and ZFP36L1; viii) determining the level of expression of at least one gene selected from the group consisting of ABCG1, ADAMTS1, ANKRD41, ANXA3, APCDD1, BCL2, BCL11A, BMP8B, C1ORF71, C1ORF76, ClORD121, C12ORF24, C16ORF73, C16ORF74, C20ORD27, C20ORF103, C20ORF112, CACNA2D3, CAMTA1, CAV1, CCDC85B, CDCA7L, CEBPD, CKAP4, CNTN4, COL8A2, CSPG5, CXCR4, DCUN1D4, DEPDC6, DMRT2, DUSP2, DZIP1, EBF3, EGR4, FAM117A, FKBP4, FL135848, FLOT2, GFI1, GMDS, GPR18, HAL, HNF4G, HSPC049, IL17D, IRX3, KBTBD11, KCNQ4, KCTD15, KIAA0146, KIAA0984, KIAA1026, KIAA1553, KLHL23, LGR4, LOC201164, LOC284454, LOC387763, LOC642083, LOC648232, MGC2408, MICAL1, MID1IP1, MSRB3, MUC19, NAPSB, NR1D2, PCDH8, PDE4B, PDGFD, PER2, PHF15, PKP2, PLK2, OAF, OSBPL1A, OSR2, OXCT2, PGM1, PMAIP1, PNMA6A, POU4F2, PSAT1, RAB33A, RASGRP2, RBM38, RET, RFTN1, SERPINB2, SERPINB10, SLAIN1, SLC1A3, SLC16A1, SLC19A1, SLC27A2, SLC29A1, SLC39A14, SLCO4A1, SNF1LK, SOX12, SPFH1, SPRY1, STEAP3, 5YDE2, SYNPO2, TARP, TEAD4, TDRD7, TMEM67, TPD52, TRGC2, TRGV2, TRGV9, TRIB3, TSPAN2, TUBA1, VIT, WDR49, WNT3, WT1, and YES1; ix) determining the level of expression of at least one gene selected from the group consisting of AHRR, CCDC36, CYP1B1, DOC1, EPB41L3, GAS7, GPR68, NPTX1, PDCD6, and TIPARP; x) determining the level of expression of at least one gene selected from the group consisting of ADRB2, COTL1, LOC285758, LOC644137, MALAT1, PRG1, RNF43, SAT1, THAP5, TIMP3, and TSC22D1; xi) determining the level of expression of at least one gene selected from the group consisting of AW011738, Bst2, Daxx, Gm16340, Hck, Herc6, Ifi202b, Ifi203, Ifi204, Ifi44, Ifi441, Ifit2, Inpp5b, LOC100044068, LOC100862473, Mx1, Oas11, Phf11d, Oyhin1, Sdc3, Setdb2, Tor3a, Usp18, and Zcchc2; xii) determining the level of expression of at least one gene selected from the group consisting of Ccdc711, D13ERTD608E, Fads2, Gm2a, Ifi2711, Ighm, Klk1, Scd2, Siglech, and Tspan2; xiii) determining the level of expression of at least one gene selected from the group consisting of Ahrr, AI607873, Atp10a, AW011738, Casp44, Cxc13, Gm9706, Ifi202b, Ifit2, Ifitm6, I118, Lcn2, LOC100044068, Ms4a6d, Mx1, Papd7, Rsad2, Slfn3, Slfn4, Tdrd7, Tiparp, and Zcchc2; xiv) determining the level of expression of at least one gene selected from the group consisting of Aldoc, Casp6, Ccdc711, Cox7a1, Egln3, Fam162a, Gfi1, Gpi1, Grhpr, Ifi2711, Ighm, Kcnq5, Klhdc2, Pgk1, Pkm, Tpi1, and Trappc6a; xv) determining the level of expression of at least one gene selected from the group consisting of 1600014C10Rik, 2810474O19Rik, 6720475J19Rik, Adam8, Adar, Agrn, Ahrr, AI607873, Amigo2, Ankfy1, Apobec1, Arf4, Asb2, Ascc3, Atp10a, Atp8b4, AW011738, B4galt5, BC147527, Bst2, Casp4, Chic1, Cmpk2, Csprs, Cxc13, Cybb, Daxx, Ddit3, Ddx24, Ddx58, Ddx60, Dpp4, Eif2ak2, Emr1, Epsti1, Evi2a, Fcgr1, Fcgr4, Ftsjd2, Gcnt1, Gm11772, Gm14446, Gm15433, Gm16340, Gm20559, Gm2666, Gm7609, Gm9706, Gpnmb, Gpr15, H2-T10, H2-T9, Hck, Helz2, Herc6, Hsh2d, Hspa1b, Ifi202b, Ifi203, Ifi204, Ifi205, Ifi2712a, Ifi35, Ifi44, Ifi441, Ifit1, Ifit1, Ifit2, Ifit3, Ifitm3, I118, I17r, Inpp5b, Ins16, Irf7, Isg20, Klrk1, Lga1s3bp, Lga1s9, LOC100041903, LOC100044068, LOC100503923, LOC100505160, LOC100862473, LOC664787, Lpar6, Ly6cl, Ly6c2, Mb21d1, Mitd1, Mlk1, Mmp8, Mnda, Mnda1, Ms4a4c, Ms4a6d, Mx1, Naa20, Nceh1, Ncoa7, Ngp, Nlrc5, Nmral1, Nqo1, Nt5c3, Oas1a, Oas2, Oas3, Oas11, Oas12, Ogfr, Papd7, Parp10, Parp11, Parp12, Parp14, Phf11d, Pik3ap1, Pla2g7, Plec, Pnpt1, Ppm1k, Pydc4, Pyhin1, Ramp3, Rnf213, Rnf8, Rsad2, Rtp4, Samd91, Scin, Sdc3, Setdb2, Sgcb, Shisa5, Slco3a1, Slfn1, Slfn3, Slfn4, Slfn5, Slfn8, Slfn9, St3ga16, Tcstv3, Tdrd7, Tiparp, Tmem140, Tmeml84b, Tnfsf10, Torlaip2, Tor3a, Trafd1, Trim25, Trim30a, Trim30d, Trim34a, Trim34b, Tspo, Uba7, Ubr4, Usp18, Wnt10a, Xaf1, Xaf1, Zc3hav1, Zcchc2, Zfyve26, Znfx1, and Zufsp; xvi) determining the level of expression of at least one gene selected from the group consisting of Ccdc711, D13ERTD608E, Fads2, Gm2a, Ifi2711, Ighm, Klk1, Scd2, Siglech, and Tspan2; xvii) determining the level of expression of at least one gene selected from the group consisting of CC12, CYBASC3, CYP1B1, FCAR, HBEGF, ID1, IL1B, IL4I1, MSC, NQO1, PPP1R15A, PRDM1, SLC7A11, SRXN1, TIPARP, TMEM138, TXNRD1, and VEGF; xviii) determining the level of expression of at least one gene selected from the group consisting of BCL2, CACNA2D3, C13ORF18, C20ORF103, C5ORF13, CDCA7, DEPDC6, GATM, HAL, HSPA1A, HSPC049, LOC645919, LRMP, OAF, POU4F2, RASGRP2, RET, SERPINB2, SERPINB8, SPFH1, and TDRD7; xix) determining the level of expression of at least one gene selected from the group consisting of ABCC1, ABHD12, ABHD5, ACPP, ACSL1, ADFP, ADORA2B, ADORA3, AHRR, AKNA, AKR1C1, AKR1C2, AKR1C3, ALAS1, ALOX5AP, ANKRD57, ANXA2, APBB1IP, APRIN, ARHGAP20, ARHGEF3, ARRB2, ARRDC4, ASB2, ATF5, ATG7, ATP6V0B, ATP6V0C, ATP9A, ATP9B, AXL, AYTL1, BCL2A1, BCL3, BCL6, BHLHB2, BTG1, BTG2, BTG3, C10ORF22, C10ORF54, C10ORF56, C12ORF35, C13ORF31, C14ORF43, C15ORF39, C17ORF32, C19ORF58, C1ORF122, C1ORF144, C1ORF162, C1ORF21, C1ORF38, C3AR1, C5ORF20, C6ORF166, C9ORF16, C9ORF88, CALN1, CARD15, CCL2, CCL5, CCND3, CCNL1, CCR1, CD109, CD244, CD300A, CD40, CD44, CD83, CD9, CDCA4, CDK5RAP2, CDKN1A, CHST11, CIDEC, CKB, CLEC5A, CLEC7A, CMTM3, CPEB2, CPEB4, CSF1R, CSGLCA-T, CSGLCA-T, CSPG2, CSPG2, CTSB, CTSH, CUTL1, CXCL1, CXCL2, CXXC5, CYBASC3, CYBB, CYLD, CYLD, CYP1B1, DDB1, DGAT2, DKFZP68601327, DOC1, DOK2, DUSP6, EBI2, ECGF1, ECOP, EFHD2, EIF1, ELL2, ELOVL1, EMP2, EMR2, EPAS1, EPB41L3, EPB41L3, EXT1, F3, FADS3, FAM100B, FCAMR, FCAR, FGD3, FGD4, FGL2, FLJ20489, FLJ20701, FLJ90013, FLRT2, FPRL1, FTH1, FUCA1, GAS7, GCNT1, GNA15, GPR35, GPR68, GSR, GSR, H2A, HBEGF, HERPUD1, HIPK2, HIST2H2AA, HIVEP1, HMOX1, HNRPLL, HPCAL1, ID1, ID2, IER5, IFI30, IFNGR1, IFNGR2, IGFBP3, MORA, IL1B, IL1R1, IL1RN, IL1RN, IL21R, IL27RA, IL27RA, IL4I1, IL4R, IRF5, ITGB7, JDP2, JUN, JUNB, JUND, KCNN4, KIAA0247, KIAA0999, KIAA1505, KIAA1706, KIAA1913, KITLG, KLF13, KLF4, KLF6, KLHL18, LACTB, LAT, LHX2, LOC113179, LOC338758, LOC440934, L0054103, LOC644242 LOC648998 LOC650429, LOC650446, LOC651816, LOC653524, LOC653361, LOC653840, LOC653361, LOC653506, LOC653610, LOC653840, LOC653626, LPAAT-THETA, LPL, LPXN, LRG1, LRP10, MAFB, MAFF, MALT1, MAML2, MAP1LC3B, MARCKSL1, MBP, MCL1, ME1, METRNL, MGAT4A, MGC13379, MGLL, MMP2, MMP9, MOBKL2A, MSC, MST150, MTF1, MTUS1, MYH10, NAB1, NCF1, NCF2, NCF4, NEU1, NFE2L3, NFKB1, NFKB2, NFKBIA, NFKBIE, NFXL1, NINJ1, NOTCH1, NOTCH2NL, NPTX1, NQO1, NRP1, NRP2, NT5E, NUAK1, P2RY5, P2RY6, PACSIN2, PDCD6, PDK4, PDLIM4, PECAM1, PEX19, PGD, PHLDA1, PHLDA2, PIK3R5, PIR, PITPNA, PKM2, PLAU, PLAUR, PLEKHO1, PNKD, POPDC3, PPIF, PPP1R15A, PRDM1, PRKCA, PSCD4, PSCDBP, PSMD1, PTAFR, PTGS1, PTPN14, PTPRE, PTX3, QPRT, RAB13, RAB27B, RAB38, RAB6IP1, RAI17, RAP2B, RAPGEF1, RCN1, RELB, RGL1, RGS1, RGS2, RIN3, RIT1, RND3, RSNL2, RSPO3, RUNX3, SAMSN1, SAP30, SASH1, SAT1, SDC4, SEMA4C, SERPINE2, SERTAD1, SFRS7, SGK, SH3GL1, SH3TC1, SLAMF8, SLC15A3, SLC16A3, SLC20A1, SLC23A2, SLC25A14, SLC25A19, SLC25A20, SLC2A1, SLC2A6, SLC37A2, SLC39A8, SLC43A2, SLC45A3, SLC4A2, SLC4A5, SLC6A6, SLC7A11, SLC7A11, SLIC1, SMOX, SNAI3, SOD2, SPRY2, SPSB1, SQRDL, SQSTM1, SRXN1, SSH1, ST3GAL5, STAT1, STK40, TFAP2A, TFDP1, TFEB, TGIF, THBD, TIPARP, TMEM138, TMTC1, TNFAIP3, TNFAIP6, TNFAIP8L1, TNFRSF10D, TNFRSF1B, TNFRSF21, TNFSF13B, TNFSF7, TP53BP2, TRAF3, TRAF3IP2, TRIB1, TRIB3, TRIM16, TRIM16L, TRPA1, TRPS1, TRPS1, TSHZ3, TTLL4, TXNRD1, UBE2S, UGCG, ULBP2, UPP1, URP2, VASH1, VEGF, VSNL1, YRDC, ZBTB24, ZCCHC10, ZFAND5, ZFP36L1, ZNF366, ZNF516, and ZNF697; xx) determining the level of expression of at least one gene selected from the group consisting of ABHD14B, ACTN1, ACY1L2, ADA, ADD2, AFF1, AIG1, AK2, AKAP1, ALS2CR13, ANKRD45, ANKRD55, APPL, ARHGEF6, ATG16L2, ATP8B3, ATP8B4, ATPBD1C, B3GNT7, BCL11A, BCL2, BMP8B, BRE, BSPRY, BTBD14A, C13ORF18, C13ORF18, C14ORF106, C15ORF41, C16ORF73, C1ORF121, C1ORF63, C1QBP, C1S, C20ORF103, C20ORF112, C20ORF12, C3ORF14, C5ORF13, C6ORF147, C7ORF24, C9ORF103, CABC1, CACNA2D3, CACYBP, CALCOCO2, CAMSAP1L1, CAMSAP1L1, CAT, CAV1, CDCA7, CERKL, CHST12, CHST5, CITED4, CLINT1, CLSTN2, CLTCL1, CNTN4, COL4A1, COL8A2, CUGBP2, CXORF21, DAB1, DENND4A, DEPDC6, DHRS9, DMRT2, DUT, EIF4A2, ESD, FLJ12078, FLJ20152, FLJ23861, FLJ36166, FOXP1, GATM, GGA2, GOLGA1, GOLGA8C, GOLGA8D, GOLGA8E, GOLGA8F, GOLGA8G, GPD1L, GPR18, HADH, HAL, HDAC9, HGF, HIG2, HISPPD1, HNRPA3, HNRPH3, HOXB3, HSPA1A, HSPA4L, HSPB1, HSPC049, ID2, ID2B, IDH1, IDH1, IHPK2, IRX3, ITGA4, KBTBD11, KCNN2, KIAA0960, KLF10, LARS, LGR4, LIMA1, LIX1L, LOC129285, LOC148203, LOC197322, LOC203274, LOC220594, LOC254559, LOC284702, LOC285084, LOC285758, LOC340061, LOC340061, LOC388189, LOC474170, LOC643458, LOC645919, LOC646456, LOC90835 LONRF1, LRMP, LYST, MACF1, MDH1, METTL7B, METTL8, MICAL1, MLSTD1, MNDA, MRPL24, MS4A3, MS4A4A, MS4A6A, MS4A7, MSRB3, MT1E, MT1H, MT1M, MTBP, MTHFD1, MTL5, MTR, MUC19, MUM1, MYADM, NAPSB, NAPSB, NAT11, NOC2L, NPAL3, OAF, OCRL, OMA1, OSBPL1A, OXCT2, PDCD4, PHACTR3, PHYH, PIGM, PIWIL4, PNMA6A, POU4F2, PRKAB2, PRLR, PSAT1, PSAT1, PTGER3, PTPLAD2, RABGAP1L, RAD17, RASGRP2, RBKS, RET, RNASEH2B, RNASET2, SELPLG, SERPINB10, SERPINB2, SERPINB8, SERPINI2, SKAP2, SLAIN1, SLC16A4, SLC22A15, SLC22A16, SLC40A1, SMARCA2, SNAPC3, SNX10, SPFH1, SPTBN1, ST3GAL3, STAR, STRBP, SYNPO2, TADA1L, TCFL5, TDRD7, THTPA, TIFA, TLE1, TMEM14A TOP2B, TPD52, TPM1, TRAF3IP3, TSPAN2, TTC9C, UBE2B, UBP1, UHRF2, VLDLR, VPS35, WASF1, WDFY1, WDR49, WDR68, WHDC1L1, WHDC1L2, ZBTB33, ZBTB44, ZF, ZNF207, ZNF519, ZNF658, and ZNF92; xxi) determining the level of expression of at least one gene selected from the group consisting of CCL2, CCL5, CXCL10, IL1RN, and MMP9; xxii) determining the level of expression of at least one gene selected from the group consisting of CCL5, CXCL10, and MMP9; xxiii) determining the level of expression of at least one gene selected from the group consisting of IL10 and CCL2; xxiv) determining the level of expression of at least one gene selected from the group consisting of IFNg, TNF, CCL3, CXCL8, and IL-10; xxv) determining the level of expression of at least one gene selected from the group consisting of MMP9, CCL2, CCL5, CXCL1, and IL1B; xxvi) determining the level of expression of at least one gene selected from the group consisting of MMP9, CXCL10, CCL2, and CCL5; xxix) determining the level of expression of at least one gene selected from the group consisting of CCL3, MMP9, CCL22, CCL24, CX3CL1, CCL20, CCL2, TNF, IL8, CCL13, CCL5, IL1B, CCL8, IL10, CXCL11, CXCL13, CXCL10, CCL7, CCL1, CXCL1, IFNg, CCL26, and MIF; or xxx) determining the level of expression of at least one gene selected from the group consisting of CCL3, MMP9, CCL22, CCL24, CX3CL1, CCL20, CCL2, TNF, IL8, CCL13, CCL5, IL1B, CCL8, IL10, CXCL11, CXCL13, CXCL10, CCL7, CCL1, CXCL1, IFNg, CCL26, MIF, IL16, IL6, CCL25, IL2, CCL19, CXCL2, CXCL9, and CXCL5,
 
thereby characterizing the glatiramer acetate related drug substance or drug product of step a).

Description:
[0001]    This application claims the benefit of U.S. Provisional Application No. 62/162,308, filed May 15, 2015, U.S. Provisional Application No. 62/134,245, filed Mar. 17, 2015, U.S. Provisional Application No. 62/078,369, filed Nov. 11, 2014, U.S. Provisional Application No. 62/047,437, filed Sep. 8, 2014, U.S. Provisional Application No. 62/025,953, filed Jul. 17, 2014, U.S. Provisional Application No. 62/020,358, filed Jul. 2, 2014, and U.S. Provisional Application No. 62/019,857, filed Jul. 1, 2014, the contents of which are hereby incorporated by reference. 
     
    
       [0002]    Throughout this application various publications are referenced by numerical identifiers in parentheses. Full citations of these references can be found following the Examples. The disclosures of these publications in their entireties are hereby incorporated by reference into this application in order to more fully describe the state of the art to which this invention pertains. 
         [0003]    Multiple sclerosis (MS) is a chronic, debilitating autoimmune disease of the central nervous system (CNS) with either relapsing-remitting (RR) or progressive course leading to neurologic deterioration and disability. At time of initial diagnosis, RRMS is the most common form of the disease (1) which is characterized by unpredictable acute episodes of neurological dysfunction (relapses), followed by variable recovery and periods of clinical stability. The vast majority of RRMS patients eventually develop secondary progressive (SP) disease with or without superimposed relapses. Around 15% of patients develop a sustained deterioration of their neurological function from the beginning; this form is called primary progressive (PP) MS. Patients who have experienced a single clinical event (Clinically Isolated Syndrome or “CIS”) and who show lesion dissemination on subsequent magnetic resonance imaging (MRI) scans according to McDonald&#39;s criteria, are also considered as having relapsing MS.(2) 
         [0004]    With a prevalence that varies considerably around the world, MS is the most common cause of chronic neurological disability in young adults.(3, 4) Anderson et al. estimated that there were about 350,000 physician-diagnosed patients with MS in the United States in 1990 (approx. 140 per 100,000 population).(5) It is estimated that about 2.5 million individuals are affected worldwide.(6) In general, there has been a trend toward an increasing prevalence and incidence of MS worldwide, but the reasons for this trend are not fully understood.(5) 
         [0005]    Current therapeutic approaches consist of i) symptomatic treatment ii) treatment of acute relapses with corticosteroids and iii) treatment aimed to modify the course of the disease. Currently approved therapies target the inflammatory processes of the disease. Most of them are considered to act as immunomodulators but their mechanisms of action have not been completely elucidated. Immunosuppressants or cytotoxic agents are also used in some patients after failure of conventional therapies. Several medications have been approved and clinically ascertained as efficacious for the treatment of RR-MS; including BETASERON®, AVONEX® and REBIF®, which are derivatives of the cytokine interferon beta (IFNB), whose mechanism of action in MS is generally attributed to its immunomodulatory effects, antagonizing pro-inflammatory reactions and inducing suppressor cells.(7) Other approved drugs for the treatment of MS include Mitoxantrone and Natalizumab. 
         [0006]    Copaxone® (Teva Pharmaceutical Industries Ltd.) is a glatiramer acetate drug product approved for treatment of patients with relapsing-remitting multiple sclerosis (RRMS) and clinically isolated syndrome (CIS) (8). Glatiramer acetate drug substance (GA), the active substance of Copaxone®, is a complex mixture of polypeptides and is the first member of the glatiramoid class; i.e., a complex mixture of synthetic polypeptides of varying sizes assembled from four naturally occurring amino acids: L-glutamic acid, L-alanine, L-lysine, and L-tyrosine, in a defined molar ratio (9). 
         [0007]    GA elicits anti-inflammatory as well as neuroprotective effects in various animal models of chronic inflammatory and neurodegenerative diseases (10-14) and has been shown to be safe and effective in reducing relapses and delaying neurologic disability in MS patients following long-term treatment (15). 
         [0008]    The mechanisms underlying GA therapeutic activity are not fully elucidated, but GA activity on immune cells has been well demonstrated. GA appears to act as an altered peptide ligand (APL) of encephalitogenic epitopes within myelin basic protein (MBP) (16) and demonstrates cross-reactivity with MBP at the humoral and cellular levels (17-23). The unique antigenic sequences of the GA polypeptide mixture compete with myelin antigens for binding to MHC class II molecules on antigen presenting cells. (APCs) and presentation to the T cell receptor (TCR), resulting in the induction of anergy or deletion of autoreactive MBP-reactive T cells and proliferation of GA-reactive T cells. At initiation of Copaxone® treatment, GA-reactive CD4+ T-cell lines from MS patients secrete both pro-inflammatory T helper type 1 (Th1) and anti-inflammatory Th2 cytokines (21, 24), but continued exposure to Copaxone® induces a shift in GA-reactive T cells toward the Th2 phenotype (21, 23, 25-28). 
         [0009]    Copaxone® also increases the number and suppressive capacity of CD4+CD25+FOXP3+ regulatory T cells, which are functionally impaired in MS patients (29-31). Furthermore, treatment leads to antigen-nonspecific modulation of APC function. Copaxone® treatment promotes development of anti-inflammatory type II monocytes characterized by an increase in interleukin (IL)-10 and transforming growth factor-beta (TGF-β) and decreased production of IL-12 and tumor necrosis factor (TNF) (32). 
       SUMMARY OF THE INVENTION 
       [0010]    The present invention provides a process for characterizing a glatiramer acetate related drug substance or drug product comprising the steps of:
   a) obtaining a batch of the glatiramer acetate related drug substance or drug product;   b) contacting mammalian cells with an amount of the glatiramer acetate related drug substance or drug product of step a); and   c) i) determining the level of expression of at least one gene selected from the group consisting of ABCF2, ABI2, ACP6, AFG3L2, ALMS1, ARPC4, CALMS, CCDC64, CD84, CDC6, CHAF1A, CLU, COX11, DLGAP1, DTX4, FAM49B, FHL1, FNTB, GYPC, HFE, IL10, LPHN1, NACA, OLAH, PATZ1, PDK1, POLI, REEP5, RPL5, RPS6KA2, SEC31A, SETBP1, SNRPA1, SYNCRIP, TNFSF9, TOMM40, TPM1, TSHZ1, TSPAN13, UBAP2, VAV3, VDAC2, and ZFAND6 (hereinafter Gene Group 1); ii) determining the level of expression of at least one gene selected from the group consisting of BIRC3, CCL24, CCR1, CISH, CSF1R, CX3CR1, CXCL10, HSPD1, ICAM1, IL1B, IFNGR1, IL27, IL2RG, IL7R, IL1RN, MMP1, MMP9, MMP14, PGRMC1, PRDM1, CARD15, CCL2, CCL5, CD14, IL10, THBD, and NFKBIA (hereinafter Gene Group 2), wherein if IL1B, IL10, or MMP9 is the at least one gene selected in part (c) (ii), then selecting at least a second different gene from the group other than IL1B, IL10, or MMP9; iii) determining the level of expression of at least one gene selected from the group consisting of C13ORF31, C14ORF10, C1ORF51, C1ORF63, CBR4, CB36, CD9, COL6A1, DAB2, GATA2, KIAA0907, LOC100506233, MCM6, MMP1, MS4A4A, MTSS1, PCMTD1, STK4, STX7, TAF15, TARP, TIA1, TMF1, TRGC2, TXNDC11, and ZCCHC7 (hereinafter Gene Group 3); iv) determining the level of expression of at least one gene selected from the group consisting of ANXA1, ARRB2, BEAN, BIN1, C1ORF63, CD44, CD9, CFP, COL6A1, CRIP2, EPB41, Fam119a, FGR, FOXO3B, HSD11B1, HSPD1P6, LOC387790, MPEG1, MYB, OLIG1, PLD1, PPP4R2, PRDM1, RBM6, SNX27, SOD2, STATH, TARP, TREM1, TRGC2, UBN2, and ZCCHC7 (hereinafter Gene Group 4); v) determining the level of expression of at least one gene selected from the group consisting of ADAM9, ADAMDEC1, AKR1C2, ANXA2, ANXA2P2, ARHGAP18, ARHGAP18, ARL6IP5, ARL6IP5, ATP2C1, BID, BIRC3, BTG1, CARD15, C1ORF21, C13ORF31, C5ORF13, C5ORF32, C9ORF130, CAST, CCL2, CCL5, CD14, CD300A, CD36, CD40, CD55, CD9, CENTA2, CHST11, COL6A1, CRYBB2, CXCL10, CYLD, DAB2, EBI3, EBI2, ECOP, EGF, FABP4, FXYD2, GHRL, GIMAP8, GLIPR1, GOS2, HMGB2, HNRPLL, ICAM1, ICAM2, IFIH1, IFNGR1, IL10, IL1ORA, IL411, INADL, ISG20, ITGB5, KIAA1505, KYNU, LACTB, LOC54103, LOC388344, LOC652751, LPAAT-THETA, LPXN, MAFB, MALT1, MFI2, MGC5618, MGLL, MITF, MLF1, MMP1, MMP9, MPEG1, MTSS1, MXD1, NT5E, NFKBIE, NFKBIA, NFE2L3, NFE2L3, OSBPL11, P2RX4, P2RY5, PLEKHO1, POPDC3, PLAUR, PRDM1, PSCDBP, PTX3, RAB27B, RCSD1, RPL13, SGIP1, SLC39A8, SNORD68, SRPX2, SRA1, SLIC1, SLAMF8, SLIC1, SOD2, STATH, STEAP1, SYNJ2, SYNJ2, TATDN3, TGM5, THBD, TNFAIP3, TNFAIP6, TNFRSF9, TNFSF13B, TPSAB1, TPSB2, TREM1, TXNL2, VPS33A, and VSNL1 (hereinafter Gene Group 5); vi) determining the level of expression of at least one gene selected from the group consisting of ACTN4, BTBD14A, C14ORF10, CISH, CLK1, CRLF3, FAM62A, FBXO45, GAPDHS, HDAC4, HIC2, HNRPD, HSPD1, LOC648342, MYB, NAPB, OXCT2, SERPINB2, SFRS14, SPFH1, STT3B, WDFY1, ZNF250, and ZNF566 (hereinafter Gene Group 6); vii) determining the level of expression of at least one gene selected from the group consisting of A2M, ABCB1, ABCC3, ABHD2, ACPP, ADAMDEC1, ADFP, ADORA2B, ADORA3, AHNAK, ALCAM, ANKH, ANKRD57, ANXA2, ANXA2P2, APBB1IP, AQP1, ARHGAP18, ARHGAP20, ARHGEF3, ARID5B, ARMC9, ATF5, ATP1B1, ATP6V0D2, ATP9A, ATP10A, AYTL1, BCL2A1, BCL6, C3AR1, C13ORD31, C9ORF88, C9ORF89, C1ORF21, C1ORF21, C10ORF95, C13ORF31, C21ORF7, CARD12, CARD15, CCDC83, CCL5, CCL24, CCND1, CCR1, CD9, CD36, CD52, CD86, CD109, CD180, CD244, CDK5RAP2, CDKN1A, CENTA2, CKB, CKLF, CLEC7A, CNIH3, COL6A1, COL22A1, CRIP2, CSF1R, CSPG4, CTSL, CTSLL3, CX3CR1, CXCR7, CYBB, CYP1B1, DAB2, DAPP1, DDIT4L, DIXDC1, DOCK4, DOK2, DKFZP56400823, DKFZP68601327, EBI2, EMP1, EMR2, ENPP2, EPAS1, EPS8, EPSTI1, EVL, FABP4, FADS3, FAM26B, FGD2, FGD2, FGD4, FGL2, FN1, FTH1, GBP2, GBP3, GBP5, GCNT1, GDPD1, GNDL, GNLY, GLIPR1, GLIS3, GPC1, GPR35, H2A/R, HAVCR2, HMCN1, HIPK2, HIST2H2AA, HIVEP1, HMOX1, HSPB7, ICAM1, ID2, ID2B, IFI30, IFI44, IFNGR1, IGFBP3, IL2RG, IL4I1, IL10RA, IL27RA, IL7R, IL10, INA, IRF7, ITGB5, ITGB7, KIAA1505, KIAA1706, KMO, LBH, LFNG, LILRB1, LILRB2, LMNA, LOC51334, LOC201895, LOC284262, LOC51334, LOC643424, LOC643834, LOC643847, LOC644242, LOC645238, LOC650429, LOC650446, LOC652543, LOC653610, LOC653754, LPAAT-THETA, LPXN, MAF, MAFB, MAML2, MAML3, MARCH1, MCOLN3, MDGA1, ME1, MFI1, MFI2, MGC45491, MGLL, MITF, MMP1, MMP2, MMP9, MMP14, MMP19, MTMR11, MTSS1, MTSU1, NGEF, NME7, NPTX1, NRCAM, NRP1, NRP2, NT5E, OAS1, OLR1, P2RY5, P2RY14, PALLD, PAPSS2, PAQP5, PCDHGA1, PCDHGA2, PCDHGA3, PCDHGA4, PCDHGA5, PCDHGA6, PCDHGA7, PCDHGA8, PCDHGA9, PCDHGA10, PCDHGA11, PCDHGA12, PCDHGB1, PCDHGB2, PCDHGB3, PCDHGB4, PCDHGB5, PCDHGB7, PCDHGC3, PCDHGC4, PCDHGC5, PDK4, PDLIM7, PFKFB4, PGA5, PDLIM4, PHLDA1, PLA2G4A, PLEKHA7, PLEKHO1, POPDC3, PRDM1, PRSS23, PSCDBP, PSD3, PTAFR, PTGS1, PTPRO, PTRF, PTX3, RAB27B, RAB38, RAB7B, RAPH1, RASGRF1, RGL1, RGS13, RHBDF1, RIN2, S100A2, SART2, SERPINE2, SERTAD1, SETBP1, SGIP1, SH3TC1, SKIL, SLA, SLAMF7, SLAMF8, SLC6AS, SLC7A11, SLC12A6, SLC37A2, SLC41A2, SLC38A6, SLC43A2, SNAI3, ST3GAL5, STATH, STEAP1, SUCNR1, SYTL1, TBXAS1, TCF4, TFAP2A, THBD, TLR4, TM7SF4, TMEM39A, TMEM158, TNCRNA, TNFSF13B, TNFRSF21, TREM1, TRIM22, TRPA1, TRPM8, TRPS1, TUBB2A, UBXD5, UGCG, UPP1, VASH1, VEGF, VSNL1, and ZFP36L1 (hereinafter Gene Group 7); viii) determining the level of expression of at least one gene selected from the group consisting of ABCG1, ADAMTS1, ANKRD41, ANXA3, APCDD1, BCL2, BCL11A, BMP8B, C1ORF71, C1ORF76, C1ORD121, C12ORF24, C16ORF73, C16ORF74, C20ORD27, C20ORF103, C20ORF112, CACNA2D3, CAMTA1, CAV1, CCDC85B, CDCA7L, CEBPD, CKAP4, CNTN4, COL8A2, CSPG5, CXCR4, DCUN1D4, DEPDC6, DMRT2, DUSP2, DZIP1, EBF3, EGR4, FAM117A, FKBP4, FL135848, FLOT2, GFI1, GMDS, GPR18, HAL, HNF4G, HSPC049, IL17D, IRX3, KBTBD11, KCNQ4, KCTD15, KIAA0146, KIAA0984, KIAA1026, KIAA1553, KLHL23, LGR4, LOC201164, LOC284454, LOC387763, LOC642083, LOC648232, MGC2408, MICAL1, MID1IP1, MSRB3, MUC19, NAPSB, NR1D2, PCDH8, PDE4B, PDGFD, PER2, PHF15, PKP2, PLK2, OAF, OSBPL1A, OSR2, OXCT2, PGM1, PMAIP1, PNMA6A, POU4F2, PSAT1, RAB33A, RASGRP2, RBM38, RET, RFTN1, SERPINE2, SERPINB10, SLAIN1, SLC1A3, SLC16A1, SLC19A1, SLC27A2, SLC29A1, SLC39A14, SLCO4A1, SNF1LK, SOX12, SPFH1, SPRY1, STEAP3, SYDE2, SYNPO2, TARP, TEAD4, TDRD7, TMEM67, TPD52, TRGC2, TRGV2, TRGV9, TRIB3, TSPAN2, TUBA1, VIT, WDR49, WNT3, WT1, and YES1 (hereinafter Gene Group 8); ix) determining the level of expression of at least one gene selected from the group consisting of AHRR, CCDC36, CYP1B1, DOC1, EPB41L3, GAS7, GPR68, NPTX1, PDCD6, and TIPARP (hereinafter Gene Group 9); x) determining the level of expression of at least one gene selected from the group consisting of ADRB2, COTL1, LOC285758, LOC644137, MALAT1, PRG1, RNF43, SAT1, THAP5, TIMP3, and TSC22D1 (hereinafter Gene Group 10); xi) determining the level of expression of at least one gene selected from the group consisting of AW011738, Bst2, Daxx, Gm16340, Hck, Herc6, Ifi202b, Ifi203, Ifi204, Ifi44, Ifi441, Ifit2, Inpp5 b, LOC100044068, LOC100862473, Mx1, Oas11, Phf11d, Oyhin1, Sdc3, Setdb2, Tor3a, Usp18, and Zcchc2 (hereinafter Gene Group 11); xii) determining the level of expression of at least one gene selected from the group consisting of Ccdc711, D13ERTD608E, Fads2, Gm2a, Ifi2711, Ighm, Klk1, Scd2, Siglech, and Tspan2 (hereinafter Gene Group 12); xiii) determining the level of expression of at least one gene selected from the group consisting of Ahrr, AI607873, Atp10a, AW011738, Casp44, Cxc13, Gm9706, Ifi202b, Ifit2, Ifitm6, I118, Lcn2, LOC100044068, Ms4a6d, Mx1, Papd7, Rsad2, Slfn3, Slfn4, Tdrd7, Tiparp, and Zcchc2 (hereinafter Gene Group 13); xiv) determining the level of expression of at least one gene selected from the group consisting of Aldoc, Casp6, Ccdc711, Cox7a1, Egln3, Fam162a, Gfi1, Gpi1, Grhpr, Ifi2711, Ighm, Kcnq5, Klhdc2, Pgk1, Pkm, Tpi1, and Trappc6a (hereinafter Gene Group 14); xv) determining the level of expression of at least one gene selected from the group consisting of 1600014C10Rik, 2810474O19Rik, 6720475J19Rik, Adam8, Adar, Agrn, Ahrr, AI607873, Amigo2, Ankfy1, Apobec1, Arf4, Asb2, Ascc3, Atp10a, Atp8b4, AW011738, B4galt5, BC147527, Bst2, Casp4, Chic1, Cmpk2, Csprs, Cxc13, Cybb, Daxx, Ddit3, Ddx24, Ddx58, Ddx60, Dpp4, Eif2ak2, Emr1, Epsti1, Evi2a, Fcgr1, Fcgr4, Ftsjd2, Gcnt1, Gm11772, Gm14446, Gm15433, Gm16340, Gm20559, Gm2666, Gm7609, Gm9706, Gpnmb, Gpr15, H2-T10, H2-T9, Hck, Helz2, Herc6, Hsh2d, Hspa1b, Ifi202b, Ifi203, Ifi204, Ifi205, Ifi2712a, Ifi35, Ifi44, Ifi441, Ifih1, Ifit1, Ifit2, Ifit3, Ifitm3, I118, I17r, Inpp5b, Ins16, Irf7, Isg20, Klrk1, Lgals3 bp, Lgals9, LOC100041903, LOC100044068, LOC100503923, LOC100505160, LOC100862473, LOC664787, Lpar6, Ly6c1, Ly6c2, Mb21d1, Mitd1, Mlk1, Mmp8, Mnda, Mnda1, Ms4a4c, Ms4a6d, Mx1, Naa20, Nceh1, Ncoa7, Ngp, Nlrc5, Nmral1, Nqo1, Nt5c3, Oas1a, Oas2, Oas3, Oas11, Oas12, Ogfr, Papd7, Parp10, Parp11, Parp12, Parp14, Phf11d, Pik3ap1, Pla2g7, Plec, Pnpt1, Ppm1k, Pydc4, Pyhin1, Ramp3, Rnf213, Rnf8, Rsad2, Rtp4, Samd9l, Scin, Sdc3, Setdb2, Sgcb, Shisa5, Slco3a1, Slfn1, Slfn3, Slfn4, Slfn5, Slfn8, Slfn9, St3gal6, Tcstv3, Tdrd7, Tiparp, Tmem140, Tmem184b, Tnfsf10, Torlaip2, Tor3a, Trafd1, Trim25, Trim30a, Trim30d, Trim34a, Trim34b, Tspo, Uba7, Ubr4, Usp18, Wnt10a, Xaf1, Xaf1, Zc3hav1, Zcchc2, Zfyve26, Znfx1, and Zufsp (hereinafter Gene Group 15); xvi) determining the level of expression of at least one gene selected from the group consisting of Ccdc711, D13ERTD608E, Fads2, Gm2a, Ifi2711, Ighm, Klk1, Scd2, Siglech, and Tspan2 (hereinafter Gene Group 16); xvii) determining the level of expression of at least one gene selected from the group consisting of CC12, CYBASC3, CYP1B1, FCAR, HBEGF, ID1, IL1B, IL4I1, MSC, NQO1, PPP1R15A, PRDM1, SLC7A11, SRXN1, TIPARP, TMEM138, TXNRD1, and VEGF (hereinafter Gene Group 17); xviii) determining the level of expression of at least one gene selected from the group consisting of BCL2, CACNA2D3, C13ORF18, C20ORF103, C5ORF13, CDCA7, DEPDC6, GATM, HAL, HSPA1A, HSPC049, LOC645919, LRMP, OAF, POU4F2, RASGRP2, RET, SERPINB2, SERPINB8, SPFH1, and TDRD7 (hereinafter Gene Group 18); xix) determining the level of expression of at least one gene selected from the group consisting of ABCC1, ABHD12, ABHD5, ACPP, ACSL1, ADFP, ADORA2B, ADORA3, AHRR, AKNA, AKR1C1, AKR1C2, AKR1C3, ALAS1, ALOX5AP, ANKRD57, ANXA2, APBB1IP, APRIN, ARHGAP20, ARHGEF3, ARRB2, ARRDC4, ASB2, ATF5, ATG7, ATP6V0B, ATP6V0C, ATP9A, ATP9B, AXL, AYTL1, BCL2A1, BCL3, BCL6, BHLHB2, BTG1, BTG2, BTG3, C10ORF22, C10ORF54, C10ORF56, C12ORF35, C13ORF31, C14ORF43, C15ORF39, C17ORF32, C19ORF58, C1ORF122, C1ORF144, C1ORF162, C1ORF21, C1ORF38, C3AR1, C5ORF20, C6ORF166, C9ORF16, C9ORF88, CALN1, CARD15, CCL2, CCL5, CCND3, CCNL1, CCR1, CD109, CD244, CD300A, CD40, CD44, CD83, CD9, CDCA4, CDK5RAP2, CDKN1A, CHST11, CIDEC, CKB, CLEC5A, CLEC7A, CMTM3, CPEB2, CPEB4, CSF1R, CSGLCA-T, CSGLCA-T, CSPG2, CSPG2, CTSB, CTSH, CUTL1, CXCL1, CXCL2, CXXC5, CYBASC3, CYBB, CYLD, CYLD, CYP1B1, DDB1, DGAT2, DKFZP68601327, DOC1, DOK2, DUSP6, EBI2, ECGF1, ECOP, EFHD2, EIF1, ELL2, ELOVL1, EMP2, EMR2, EPAS1, EPB41L3, EPB41L3, EXT1, F3, FADS3, FAM100B, FCAMR, FCAR, FGD3, FGD4, FGL2, FLJ20489, FLJ20701, FLJ90013, FLRT2, FPRL1, FTH1, FUCA1, GAS7, GCNT1, GNA15, GPR35, GPR68, GSR, GSR, H2A, HBEGF, HERPUD1, HIPK2, HIST2H2AA, HIVEP1, HMOX1, HNRPLL, HPCAL1, ID1, ID2, IER5, IFI30, IFNGR1, IFNGR2, IGFBP3, IL1ORA, IL1B, IL1R1, IL1RN, IL1RN, IL21R, IL27RA, IL27RA, IL411, IL4R, IRF5, ITGB7, JDP2, JUN, JUNB, JUND, KCNN4, KIAA0247, KIAA0999, KIAA1505, KIAA1706, KIAA1913, KITLG, KLF13, KLF4, KLF6, KLHL18, LACTB, LAT, LHX2, LOC113179, LOC338758, LOC440934, LOC54103, LOC644242, LOC648998, LOC650429, LOC650446, LOC651816, LOC653524, LOC653361, LOC653840, LOC653361, LOC653506, LOC653610, LOC653840, LOC653626, LPAAT-THETA, LPL, LPXN, LRG1, LRP10, MAFB, MAFF, MALT1, MAML2, MAP1LC3B, MARCKSL1, MBP, MCL1, ME1, METRNL, MGAT4A, MGC13379, MGLL, MMP2, MMP9, MOBKL2A, MSC, MST150, MTF1, MTUS1, MYH10, NAB1, NCF1, NCF2, NCF4, NEU1, NFE2L3, NFKB1, NFKB2, NFKBIA, NFKBIE, NFXL1, NINJ1, NOTCH1, NOTCH2NL, NPTX1, NQO1, NRP1, NRP2, NT5E, NUAK1, P2RY5, P2RY6, PACSIN2, PDCD6, PDK4, PDLIM4, PECAM1, PEX19, PGD, PHLDA1, PHLDA2, PIK3R5, PIR, PITPNA, PKM2, PLAU, PLAUR, PLEKHO1, PNKD, POPDC3, PPIF, PPP1R15A, PRDM1, PRKCA, PSCD4, PSCDBP, PSMD1, PTAFR, PTGS1, PTPN14, PTPRE, PTX3, QPRT, RAB13, RAB27B, RAB38, RAB6IP1, RAI17, RAP2B, RAPGEF1, RCN1, RELB, RGL1, RGS1, RGS2, RIN3, RIT1, RND3, RSNL2, RSPO3, RUNX3, SAMSN1, SAP30, SASH1, SAT1, SDC4, SEMA4C, SERPINE2, SERTAD1, SFRS7, SGK, SH3GL1, SH3TC1, SLAMF8, SLC15A3, SLC16A3, SLC20A1, SLC23A2, SLC25A14, SLC25A19, SLC25A20, SLC2A1, SLC2A6, SLC37A2, SLC39A8, SLC43A2, SLC45A3, SLC4A2, SLC4A5, SLC6A6, SLC7A11, SLC7A11, SLIC1, SMOX, SNAI3, SOD2, SPRY2, SPSB1, SQRDL, SQSTM1, SRXN1, SSH1, ST3GAL5, STAT1, STK40, TFAP2A, TFDP1, TFEB, TGIF, THBD, TIPARP, TMEM138, TMTC1, TNFAIP3, TNFAIP6, TNFAIP8L1, TNFRSF10D, TNFRSF1B, TNFRSF21, TNFSF13B, TNFSF7, TP53BP2, TRAF3, TRAF3IP2, TRIB1, TRIB3, TRIM16, TRIM16L, TRPA1, TRPS1, TRPS1, T5HZ3, TTLL4, TXNRD1, UBE2S, UGCG, ULBP2, UPP1, URP2, VASH1, VEGF, VSNL1, YRDC, ZBTB24, ZCCHC10, ZFAND5, ZFP36L1, ZNF366, ZNF516, and ZNF697 (hereinafter Gene Group 19); xx) determining the level of expression of at least one gene selected from the group consisting of ABHD14B, ACTN1, ACY1L2, ADA, ADD2, AFF1, AIG1, AK2, AKAP1, ALS2CR13, ANKRD45, ANKRD55, APPL, ARHGEF6, ATG16L2, ATP8B3, ATP8B4, ATPBD1C, B3GNT7, BCL11A, BCL2, BMP8B, BRE, BSPRY, BTBD14A, C13ORF18, C13ORF18, C14ORF106, C15ORF41, C16ORF73, C1ORF121, C1ORF63, C1QBP, C1S, C20ORF103, C20ORF112, C20ORF12, C3ORF14, C5ORF13, C6ORF147, C7ORF24, C9ORF103, CABC1, CACNA2D3, CACYBP, CALCOCO2, CAMSAP1L1, CAMSAP1L1, CAT, CAV1, CDCA7, CERKL, CHST12, CHST5, CITED4, CLINT1, CLSTN2, CLTCL1, CNTN4, COL4A1, COL8A2, CUGBP2, CXORF21, DAB1, DENND4A, DEPDC6, DHRS9, DMRT2, DUT, EIF4A2, ESD, FLJ12078, FLJ20152, FLJ23861, FLJ36166, FOXP1, GATM, GGA2, GOLGA1, GOLGA8C, GOLGA8D, GOLGA8E, GOLGA8F, GOLGA8G, GPD1L, GPR18, HADH, HAL, HDAC9, HGF, HIG2, HISPPD1, HNRPA3, HNRPH3, HOXB3, HSPA1A, HSPA4L, HSPB1, HSPC049, ID2, ID2B, IDH1, IDH1, IHPK2, IRX3, ITGA4, KBTBD11, KCNN2, KIAA0960, KLF10, LARS, LGR4, LIMA1, LIX1L, LOC129285, LOC148203, LOC197322, LOC203274, LOC220594, LOC254559, LOC284702, LOC285084, LOC285758, LOC340061, LOC340061, LOC388189, LOC474170, LOC643458, LOC645919, LOC646456, LOC90835 LONRF1, LRMP, LYST, MACF1, MDH1, METTL7B, METTL8, MICAL1, MLSTD1, MNDA, MRPL24, MS4A3, MS4A4A, MS4A6A, MS4A7, MSRB3, MT1E, MT1H, MT1M, MTBP, MTHFD1, MTL5, MTR, MUC19, MUM1, MYADM, NAPSB, NAPSB, NAT11, NOC2L, NPAL3, OAF, OCRL, OMA1, OSBPL1A, OXCT2, PDCD4, PHACTR3, PHYH, PIGM, PIWIL4, PNMA6A, POU4F2, PRKAB2, PRLR, PSAT1, PSAT1, PTGER3, PTPLAD2, RABGAP1L, RAD17, RASGRP2, RBKS, RET, RNASEH2B, RNASET2, SELPLG, SERPINB10, SERPINB2, SERPINB8, SERPINI2, SKAP2, SLAIN1, SLC16A4, SLC22A15, SLC22A16, SLC40A1, SMARCA2, SNAPC3, SNX10, SPFH1, SPTBN1, ST3GAL3, STAR, STRBP, SYNPO2, TADA1L, TCFL5, TDRD7, THTPA, TIFA, TLE1, TMEM14A TOP2B, TPD52, TPM1, TRAF3IP3, TSPAN2, TTC9C, UBE2B, UBP1, UHRF2, VLDLR, VPS35, WASF1, WDFY1, WDR49, WDR68, WHDC1L1, WHDC1L2, ZBTB33, ZBTB44, ZF, ZNF207, ZNF519, ZNF658, and ZNF92 (hereinafter Gene Group 20); xxi) determining the level of expression of at least one gene selected from the group consisting of CCL2, CCL5, CXCL10, IL1RN, and MMP9 (hereinafter Gene Group 21); xxii) determining the level of expression of at least one gene selected from the group consisting of CCL5, CXCL10, and MMP9 (hereinafter Gene Group 22); xxiii) determining the level of expression of at least one gene selected from the group consisting of IL10 and CCL2 (hereinafter Gene Group 23); xxiv) determining the level of expression of at least one gene selected from the group consisting of IFNg, TNF, CCL3, CXCL8, and IL-10 (hereinafter Gene Group 24); xxv) determining the level of expression of at least one gene selected from the group consisting of MMP9, CCL2, CCL5, CXCL1, and IL1B (hereinafter Gene Group 25); xxvi) determining the level of expression of at least one gene selected from the group consisting of MMP9, CXCL10, CCL2, and CCL5 (hereinafter Gene Group 26); xxix) determining the level of expression of at least one gene selected from the group consisting of CCL3, MMP9, CCL22, CCL24, CX3CL1, CCL20, CCL2, TNF, IL8, CCL13, CCL5, IL1B, CCL8, IL10, CXCL11, CXCL13, CXCL10, CCL7, CCL1, CXCL1, IFNg, CCL26, and MIF (hereinafter Gene Group 29); or xxx) determining the level of expression of at least one gene selected from the group consisting of CCL3, MMP9, CCL22, CCL24, CX3CL1, CCL20, CCL2, TNF, IL8, CCL13, CCL5, IL1B, CCL8, IL10, CXCL11, CXCL13, CXCL10, CCL7, CCL1, CXCL1, IFNg, CCL26, MIF, IL16, IL6, CCL25, IL2, CCL19, CXCL2, CXCL9, and CXCL5 (hereinafter Gene Group 30),
 
thereby characterizing the glatiramer acetate related drug substance or drug product of step a).
   
 
         [0014]    The present invention also provides a process for discriminating between glatiramer acetate related drug substances or drug products comprising the steps of:
   a) characterizing two or more glatiramer acetate related drug substances or drug products according to the process of the claimed invention to obtain characteristics of each of the glatiramer acetate related drug substances or drug products; and   b) comparing the characteristics of the glatiramer acetate related drug substances or drug products obtained in step a), thereby discriminating between glatiramer acetate related drug substances or drug products.   
 
         [0017]    The present invention also provides a process for characterizing a glatiramer acetate related drug substance or drug product comprising the steps of:
   a) obtaining a batch of the glatiramer acetate related drug substance or drug product;   b) contacting mammalian cells with an amount of the glatiramer acetate related drug substance or drug product of step a); and   c) xxii) determining the protein level expression of at least one protein selected from the group consisting of RANTES, IP-10, and MMP-9 (hereinafter Protein Group A); xxiii) determining the protein level expression of at least one protein selected from the group consisting of IL10 and MCP-1 (hereinafter Protein Group B); xxiv) determining the protein level expression of at least one protein selected from the group consisting of IFNg, TNFa, MIP-1a, IL-8, and IL-10 (hereinafter Protein Group C); xxv) determining the protein level expression of at least one protein selected from the group consisting of MMP-9, MCP-1, RANTES, Gro-a, and IL-1b (hereinafter Protein Group D); xxvi) determining the protein level expression of at least one protein selected from the group consisting of MMP-9, IP-10, MCP-1, and RANTES (hereinafter Protein Group E); xxvii) determining the protein level expression of at least one protein selected from the group consisting of MIP-1a, MMP-9, MDC, CCL24, CX3CL1, MIP-3a, MCP-1, TNF-α, IL-8, MCP-4, RANTES, IL-1b, MCP-2, IL-10, I-TAC, CXCL13, IP-10, MCP-3, CCL1, CXCL1, INF-g, CCL26, and MIF (hereinafter Protein Group F); or xxviii) determining the protein level 3U expression of at least one protein selected from the group consisting of MIP-1a, MMP-9, MDC, CCL24, CX3CL1, MIP-3a, MCP-1, TNF-a, IL-8, MCP-4, RANTES, IL-1b, MCP-2, IL-10, I-TAC, CXCL13, IP-10, MCP-3, CCL1, CXCL1, INF-g, CCL26, MIF, IL-16, IL-6, TECK, IL-2, MIP-3b, CXCL2, MIG, and CXCL5 (hereinafter Protein Group G),
 
thereby characterizing the glatiramer acetate related drug substance or drug product of step a).
   
 
         [0021]    The present invention also provides a process for characterizing a glatiramer acetate related drug substance or drug product comprising the steps of:
   a) obtaining a batch of the glatiramer acetate related drug substance or drug product;   b) contacting mammalian cells with an amount of the glatiramer acetate related drug substance or drug product of step a); and   c) i) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 1; ii) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 2, wherein if IL1B, IL10, or MMP9 is the at least one gene selected in part (c)(ii), then selecting at least a second different gene from the group other than IL1B, IL10, or MMP9; iii) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 3; iv) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 4; v) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 5; vi) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 6; vii) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 7; viii) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 8; ix) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 9; x) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 10; xi) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 11; xii) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 12; xiii) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 13; xiv) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 14; xv) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 15; xvi) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 16; xvii) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 17; xviii) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 18; xix) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 19; xx) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 20; xxi) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 21; xxii) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 22; xxiii) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 23; xxiv) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 24; xxv) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 25; xxvi) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 26; xxix) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 29; or xxx) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 30,
 
thereby characterizing the glatiramer acetate related drug substance or drug product of step a).
   
 
     
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         [0025]      FIG. 1 : Framework of studies conducted in mouse splenocytes and human THP-1 monocyte cell line. 
           [0026]      FIG. 2 : Roadmap for human THP-1 monocyte cell line study. 
           [0027]      FIG. 3 : Levels of Copaxone® measured over time in cell culture medium from human THP-1 monocyte cell line. Copaxone® concentration in medium over time remains steady in the range of 44-52 μg/mL over 24 hours. 
           [0028]      FIGS. 4A-D : Differentially expressed genes in human THP-1 monocyte cell line (a) Increased expression of IL10 with GA treatment at 6 hours for the single IL10 probeset on the array (207433_at) (FDR adjusted p&lt;3.1e-9); (b-d) Increased expression of IL1RN with GA treatment at 6 hours for multiple probesets (adjusted p values as shown). 
           [0029]      FIG. 5 : Pathways enriched in experimental systems in mouse splenocytes, human THP-1 monocyte cell line and PBMCs from MS patients among top genes modulated by Copaxone® at 6 hours (subject to FC and adjusted p value filters of 1.5 and 1e-5, respectively). The volcano plot show-log (adjusted p value) for the enrichment plotted versus the fold enrichment score from DAVID for each pathway. A selected subset of pathways are labeled. 
           [0030]      FIG. 6 : Probeset for cytokine-cytokine receptor interaction pathway genes significantly modulated by Copaxone® at 6 hours in human THP-1 monocyte cell line (subject to FC and adjusted p value filters of 1.5 and 1e-5, respectively). The volcano plot show-log (adjusted p value) for differential pexpression plotted versus the fold change from LIMMA for each probeset. 
           [0031]      FIG. 7 : MMP9 is significantly upregulated by Probioglat stimulation in human THP-1 monocyte cell line compared to Copaxone® stimulation at 6 and 24 hours (FDR adjusted p values for each timepoint are 2.74e-6, 0.098, and 0.004 for 6, 12, and 24 hours, respectively). 
           [0032]      FIG. 8 : CD14 expression in human THP-1 monocyte cell line is significantly higher with Probioglat stimulation compared to Copaxone® stimulation at 6 hours. 
           [0033]      FIG. 9 : Focus on the “response to LPS” pathway as differentially expressed by Probioglat versus Copaxone® at 6 hours in human THP-1 monocyte cell line. 
           [0034]      FIG. 10 : Pathway-level analysis depicts enrichment among genes upregulated by Probioglat stimulation compared with Copaxone® at 6 hours in human THP-1 monocyte cell line (a) Pathways enriched among genes upregulated by Probioglat stimulation compared with GA at 6 hours. The volcano plot shows −log (adjusted p value) for the enrichment plotted versus the fold enrichment score from DAVID for each pathway; (b) Focus on response to LPS pathway, differentially expressed by Probioglat versus GA at 6 hours. The volcano plot shows −log (adjusted p value) for differential expression plotted versus the fold change from LIMMA for each probeset. A selected subset of pathways are labeled. 
           [0035]      FIG. 11 : Each present probeset for ICAM1 is significantly upregulated by Probioglat stimulation compared to Copaxone® stimulation at 6 hours in human THP-1 monocyte cell line. 
           [0036]      FIG. 12 : CISH is downregulated by Probioglat stimulation compared to Copaxone® stimulation at 6 hours in human human THP-1 monocyte cell line. 
           [0037]      FIG. 13 : Upregulation of IL10 with GA treatment in all three studies in mouse splenocytes, human THP-1 monocyte cell line and PBMCs from MS patients. 
           [0038]      FIG. 14 : Overlap of genes significantly modulated by GA between studies in three model systems in mouse splenocytes, human THP-1 monocyte cell line and PBMCs from MS patients. 
           [0039]      FIGS. 15A-B : Higher levels of (a) CD14 and (b) CD40 (bottom) are induced by a Probioglat generic than by Copaxone® or other generics in human monocytes. 
           [0040]      FIG. 16 : Expression of IL1B in Copaxone® and multiple generics in mouse splenocytes. 
           [0041]      FIG. 17 : Expression of CD44 in Copaxone and Escadra generic in human monocytes. 
           [0042]      FIG. 18 : IL27 expression in Copaxone® and various generics in mouse splenocytes. 
           [0043]      FIG. 19 : MMP9 expression induced by Copaxone®, Probioglat, and other generics in human monocytes. 
           [0044]      FIG. 20 : Significant gene expression difference are observed between Copaxone® and the purported generics Natco and Escadra in many genes, including several relevant to MS. 
           [0045]      FIG. 21 : MMP14 expression is significantly elevated by TV-5010 relative to Copaxone® in mouse splenocytes. 
           [0046]      FIG. 22 : The expression of PGRMC1 and IL1B shows significantly different expression following stimulation with proposed generics from different manufacturers in human THP-1 monocytes. 
           [0047]      FIG. 23 : Pathway-level analysis depicts enrichment among genes upregulated by Copaxone® stimulation compared with mannitol control at 6 hours in human THP-1 monocyte cell line. 
           [0048]      FIG. 24 : IL1RN is significantly upregulated by Copaxone stimulation in human THP-1 monocyte cell line compared to mannitol control at 6 hours (FDR adjusted p value&lt;2.8e-10). 
           [0049]      FIG. 25 a   : Higher level of CYP1B1 is induced by Polimunol generic than by Copaxone® in human THP-1 monocyte cell line at 6 hours (FDR adjusted p values&lt;1.5e-10). 
           [0050]      FIG. 25 b   : Higher level of GPR68 is induced by Polimunol generic than by Copaxone® in human THP-1 monocyte cell line at 6 hours (FDR adjusted p values&lt;1.5e-5). 
           [0051]      FIG. 26 : Lower level of ADRB2 is induced by Polimunol generic than by Copaxone® in human THP-1 monocyte cell line at 6 hours (FDR adjusted p value&lt;0.009). 
           [0052]      FIGS. 27A-E : Copaxone® treatment in mouse splenocytes upregulated (a-b) anti-inflammatory cytokines and (c-d) markers of regulatory T cells, and (e) downregulated pro-inflammatory cytokines. 
           [0053]      FIG. 28 : Pathways enriched among probesets modulated by Copaxone® relative to medium in splenocytes from mice immunized with Copaxone®. 
           [0054]      FIG. 29 : IL18 expression is reduced to a greater extent by Copaxone® than Polimunol, regardless of which substance is utilized for the immunization in mouse splenocytes. 
           [0055]      FIG. 30 : Pathways enriched among top probesets upregulated by Polimunol relative to Copaxone® (in Copaxone®-immunized mice). 
           [0056]      FIG. 31 : Pathways enriched among top probesets upregulated by Polimunol relative to Copaxone® (in Polimunol-immunized mice). 
           [0057]      FIG. 32 a   : IL-18 signaling pathway (from Dinarello, Front Immunol, 2013;  FIG. 1 ). 
           [0058]      FIG. 32 b   : Mice definicient for IL-18 are resistant to EAE (from Shi, J. Immuno, 2000;  FIG. 1 a   ). 
           [0059]      FIG. 33 : Type I interferon signaling pathway (from Trinchieri et al, Journal of Experimental Medicine, 2010;  FIG. 1 ) 
           [0060]      FIGS. 34A-C : Anti-inflammatory gene IL1RN is significantly upregulated by Copaxone in human THP-1 monocyte cell line. 
           [0061]      FIG. 35 : Pathways enriched among top probesets modulated by Copaxone relative to mannitol control in human THP-1 monocyte cell line. 
           [0062]      FIG. 36 : Genes in the cytokine-cytokine receptor interaction pathway modulated by Copaxone® relative to mannitol control (each point represents a probeset, labeled with its gene annotation) in human THP-1 monocyte cell line. 
           [0063]      FIG. 37 : CYP1B1 is significantly upregulated by Polimunol relative to Copaxone®. 
           [0064]      FIG. 38 : Pathways significantly enriched among top probesets differentially expressed between Polimunol and Copaxone®. 
           [0065]      FIG. 39 : Genes in the cytokine-cytokine receptor interaction pathway, which is significantly enriched among top probesets differentially expressed between Polimunol and Copaxone® (each point represents a probeset, labeled with its gene annotation). 
           [0066]      FIG. 40 a   : Volcano plot showing probesets driving the enrichment of the response to lipopolysaccharide pathway among probesets upregulated by Polimunol relative to Copaxone®. The dashed line indicates significance level of adjusted p value&lt;0.05. 
           [0067]      FIG. 40 b   : Volcano plot showing probesets driving the enrichment of the response to lipopolysaccharide pathway among probesets upregulated by Probioglat relative to Copaxone® in prior study (FDA-2014-P-0933-0001 available at www.regulations.gov/#?documentDetail;D=FDA-2014-P-0933-0001, and also described herein). The dashed line indicates significance level of adjusted p value&lt;0.05. 
           [0068]      FIG. 41 : Expression levels of genes differing between Probioglat and GA (a) MMP9 is significantly upregulated following stimulation by Probioglat compared to GA at 6 and 24 hours (FDR-adjusted p values for the single MMP9 probeset on the chip, 203936_s_at, are 2.74e-6, 0.098, and 0.004 for the 6, 12, and 24 hour timepoints, respectively); (b) CD14 expression is significantly higher with stimulation by Probioglat compared to GA at 6 hours (the single CD14 probeset on the chip is shown, 201743_at); (c) Both present ICAM1 probesets are significantly upregulated following stimulation by Probioglat compared to GA at 6 hours (A: probeset 202637_s_at; B: probeset 202638_s_at); (d) CISH is downregulated following stimulation by Probioglat compared to GA at 6 hours (both present probesets are shown, A: probeset 223961_s_at; B: probeset 223377_x_at). 
           [0069]      FIG. 42 : Expression levels of genes differing between Probioglat and GA by qRT-PCR in primary human monocytes. CCL2 (p&lt;0.009), CCL5 (p&lt;0.029), CXCL10 (p&lt;0.020), MMP9 (p&lt;0.009), and IL1RN (p&lt;0.013) are expressed more highly under Probioglat stimulation relative to GA stimulation. 
           [0070]      FIG. 43 : Principal Component Analysis (PCA; a multivariate approach) showed that the main effect in the first principal component remained due to treatment effects after batch correction (a) First principal component accounts for experimental factor (treatment time 6, 12, 24 hours); (b) PCA demonstrates batch effect correction required for scan date (legand as in (c)); (c) After batch correction, PCA shows more uniform distribution of scan dates. 
           [0071]      FIG. 44 : Box plots showing maximum and minimum expression values for Probioglat (red lines) and Copaxone (blue lines). 
           [0072]      FIGS. 45A-B : Protein levels at 24 hours are consistent with upregulation of pro-inflammatory mRNA markers by Probioglat vesus Copaxone® treatment at 6h (a) CCL, CXCL10 and MMP-9 protein levels are higher with Probioglat versus Copaxone at 24 hr, consistent with mRNA level observations by RT-PCR and microarray in THP-1 cells; (b) CCL2 and IL-10 protein levels are higher with Probioglat versus Copaxone at 24 hr, consistent with mRNA level observations by microarray (not tested by RT-PCR in THP-1 cells. 
           [0073]      FIG. 46 : Number of relapses reported to the Patient Support Program in Mexico. 
           [0074]    FIGS.  47 A_E: Levels of Secreted Protein with Polimunol Versus GA Treatment: Levels of IFNg, TNFa, MIP1a (CCL3), IL-8 (CXCL8), and IL-10 were higher with Polimunol versus GA treatment. 
           [0075]      FIGS. 48A-E : Levels of Secreted Protein with Polimunol Versus GA Treatment: Consistent with gene level data, levels of MMP-9, MCP-1 (CCL2), RANTES (CCL5), Gro-a (CXCL1), and IL-1b were higher with Polimunol versus GA treatment. 
           [0076]      FIGS. 49A-E : Levels of Secreted Protein with Probioglat Versus GA Treatment: Levels of IFNg, TNFa, MIP1a (CCL3), IL-8 (CXCL8), and IL-10 were higher with Probioglat versus GA treatment. 
           [0077]      FIGS. 50A-D : Levels of Secreted Protein with Probioglat Versus GA Treatment: Consistent with gene level data, levels of MMP-9, MCP-1 (CCL2), RANTES (CCL5), and IP-10 (CXCL10) were higher with Probioglat versus GA treatment. 
       
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
     Embodiments of the Invention 
       [0078]    The present invention provides a process for characterizing a glatiramer acetate related drug substance or drug product comprising the steps of:
   a) obtaining a batch of the glatiramer acetate related drug substance or drug product;   b) contacting mammalian cells with an amount of the glatiramer acetate related drug substance or drug product of step a); and   c) i) determining the level of expression of at least one gene selected from the group consisting of Gene Group 1; ii) determining the level of expression of at least one gene selected from the group consisting of Gene Group 2, wherein if IL1B, IL10, or MMP9 is the at least one gene selected in part (c)(ii), then selecting at least a second different gene from the group other than IL1B, IL10, or MMP9; iii) determining the level of expression of at least one gene selected from the group consisting of Gene Group 3; iv) determining the level of expression of at least one gene selected from the group consisting of Gene Group 4; v) determining the level of expression of at least one gene selected from the group consisting of Gene Group 5; vi) determining the level of expression of at least one gene selected from the group consisting of Gene Group 6; vii) determining the level of expression of at least one gene selected from the group consisting of Gene Group 7; viii) determining the level of expression of at least one gene selected from the group consisting of Gene Group 8; ix) determining the level of expression of at least one gene selected from the group consisting of Gene Group 9; x) determining the level of expression of at least one gene selected from the group consisting of Gene Group 10; xi) determining the level of expression of at least one gene selected from the group consisting of Gene Group 11; xii) determining the level of expression of at least one gene selected from the group consisting of Gene Group 12; xiii) determining the level of expression of at least one gene selected from the group consisting of Gene Group 13; xiv) determining the level of expression of at least one gene selected from the group consisting of Gene Group 14; xv) determining the level of expression of at least one gene selected from the group consisting of Gene Group 15; xvi) determining the level of expression of at least one gene selected from the group consisting of Gene Group 16; xvii) determining the level of expression of at least one gene selected from the group consisting of Gene Group 17; xviii) determining the level of expression of at least one gene selected from the group consisting of Gene Group 18; xix) determining the level of expression of at least one gene selected from the group consisting of Gene Group 19; xx) determining the level of expression of at least one gene selected from the group consisting of Gene Group 20; xxi) determining the level of expression of at least one gene selected from the group consisting of Gene Group 21; xxii) determining the level of expression of at least one gene selected from the group consisting of Gene Group 22; xxiii) determining the level of expression of at least one gene selected from the group consisting of Gene Group 23; xxiv) determining the level of expression of at least one gene selected from the group consisting of Gene Group 24; xxv) determining the level of expression of at least one gene selected from the group consisting of Gene Group 25; xxvi) determining the level of expression of at least one gene selected from the group consisting of Gene Group 26; xxix) determining the level of expression of at least one gene selected from the group consisting of Gene Group 29; or xxx) determining the level of expression of at least one gene selected from the group consisting of Gene Group 30,
 
thereby characterizing the glatiramer acetate related drug substance or drug product of step a).
   
 
         [0082]    In some embodiments of the present invention step (c) comprises i) determining the level of expression of at least one gene selected from the group consisting of Gene Group 1; ii) determining the level of expression of at least one gene selected from the group consisting of Gene Group 3; or vi) determining the level of expression of at least one gene selected from the group consisting of Gene Group 6. 
         [0083]    In some embodiments of the present invention, all genes Gene Group 1, are selected for determining the level of expression. 
         [0084]    In some embodiments of the present invention, all genes ABCF2, ABI2, ACP6, AFG3L2, ALMS1, ARPC4, CALM3, CCDC64, CD84, CDC6, CHAF1A, CLU, COX11, DLGAP1, DTX4, FAM49B, FHL1, FNTB, GYPC, HFE, LPHN1, OLAH, PATZ1, PDK1, POLI, REEP5, RPS6KA2, SEC31A, SETBP1, SNRPA1, SYNCRIP, TNFSF9, TOMM40, TPM1, TSPAN13, UBAP2, VAV3, VDAC2, and ZFAND6, are selected for determining the level of expression. 
         [0085]    In some embodiments of the present invention, if the at least one gene selected in part(c)(i) is IL10, the process comprises the step of selecting at least a second different gene from the group of (c)(i) and (c)(ii) other than IL10. 
         [0086]    In some embodiments of the present invention, if the at least one gene selected in part(c) (ii) is CARD15, CCL2, CCL5, CD14, IL10, THBD, or NFKBIA, the process comprises the step of selecting at least a second different gene from the group of (c)(i) and (c)(ii) other than CARD15, CCL2, CCL5, CD14, IL10, THBD, or NFKBIA. 
         [0087]    In one or more embodiments of the present invention, if two or more genes are selected in step (c), then the second or additional gene selected is different from the other selected gene or genes 
         [0088]    In one or more embodiments of the present invention, the level of expression is determined for all genes identified in Table 5 or Table 12 to be involved in one or more than one pathway. 
         [0089]    In one or more embodiments of the present invention, the level of expression is determined for at least one gene identified in Table 5 or Table 12 to be involved in at least one pathway. 
         [0090]    In one or more embodiments of the present invention, the level of expression is determined for at least one gene identified in Table 5 or Table 12 to be involved in two or more pathways. 
         [0091]    In one or more embodiments of the present invention, the level of expression is determined for at least one gene identified in Table 5 or Table 12 to be involved in three or more pathways. 
         [0092]    In one or more embodiments of the present invention, the level of expression is determined for at least one gene identified in Table 5 or Table 12 to be involved in four or more pathways. 
         [0093]    In one or more embodiments of the present invention, the level of expression is determined for at least one gene identified in Table 5 or Table 12 to be involved in five or more pathways. 
         [0094]    In one or more embodiments of the present invention, the level of expression is determined for at least one gene identified in Table 5 or Table 12 to be involved in six pathways. 
         [0095]    In one or more embodiments of the present invention, the level of expression is determined for at least one gene which is involved in only one pathway set forth in Table 5 or Table 12. 
         [0096]    In one or more embodiments of the present invention, the level of expression is determined for at least two genes identified in Table 5 or Table 12 to be involved in the same pathway. 
         [0097]    In one or more embodiments of the present invention, the level of expression is determined for at least three genes identified in Table 5 or Table 12 to be involved in the same pathway. 
         [0098]    In one or more embodiments of the present invention, the level of expression is determined for at least four genes identified in Table 5 or Table 12 to be involved in the same pathway. 
         [0099]    In one or more embodiments of the present invention, the level of expression is determined for at least five genes identified in Table 5 or Table 12 to be involved in the same pathway. 
         [0100]    In one or more embodiments of the present invention, the level of expression is determined for at least six genes identified in Table 5 or Table 12 to be involved in the same pathway. 
         [0101]    In one or more embodiments of the present invention, the level of expression is determined for all genes identified in Table 6 to be involved in one or more than one pathway. 
         [0102]    In one or more embodiments of the present invention, the level of expression is determined for at least one gene identified in Table 6 to be involved in at least one pathway. 
         [0103]    In one or more embodiments of the present invention, the level of expression is determined for at least one gene identified in Table 6 to be involved in two or more pathways. 
         [0104]    In one or more embodiments of the present invention, the level of expression is determined for at least one gene identified in Table 6 to be involved in three or more pathways. 
         [0105]    In one or more embodiments of the present invention, the level of expression is determined for at least one gene identified in Table 6 to be involved in four or more pathways. 
         [0106]    In one or more embodiments of the present invention, the level of expression is determined for at least one gene identified in Table 6 to be involved in five or more pathways. 
         [0107]    In one or more embodiments of the present invention, the level of expression is determined for at least one gene identified in Table 6 to be involved in six or more pathways. 
         [0108]    In one or more embodiments of the present invention, the level of expression is determined for at least one gene which is involved in only one pathway set forth in Table 6. 
         [0109]    In one or more embodiments of the present invention, the level of expression is determined for at least two genes identified in Table 6 to be involved in the same pathway. 
         [0110]    In one or more embodiments of the present invention, the level of expression is determined for at least three genes identified in Table 6 to be involved in the same pathway. 
         [0111]    In one or more embodiments of the present invention, the level of expression is determined for at least four genes identified in Table 6 to be involved in the same pathway. 
         [0112]    In one or more embodiments of the present invention, the level of expression is determined for at least five genes identified in Table 6 to be involved in the same pathway. 
         [0113]    In one or more embodiments of the present invention, the level of expression is determined for at least six genes identified in Table 6 to be involved in the same pathway. 
         [0114]    In one or more embodiments of the present invention, contacting the mammalian cells in step (b) comprises i) administering to a mammal a predetermined amount of glatiramer acetate related drug substance or drug product of step (a), or ii) incubating the cells with an amount of the glatiramer acetate related drug substance or drug product of step (a), or a combination thereof; and wherein step (c) comprises i) determining the level of expression of at least one gene selected from the group consisting of Gene Group 1, thereby characterizing the glatiramer acetate related drug substance or drug product of step (a). 
         [0115]    In one or more embodiments of the present invention, contacting the mammalian cells in step (b) comprises i) administering to a mammal a predetermined amount of glatiramer acetate related drug substance or drug product of step (a), and ii) obtaining cells from the mammal at one or more predetermined time points; and wherein step (c) comprises determining the level of expression of at least one gene selected from the group consisting of Gene Group 1, thereby characterizing the glatiramer acetate related drug substance or drug product of step (a). 
         [0116]    In one or more embodiments, the mammal is human and the cells are peripheral mononuclear blood cells. 
         [0117]    In one or more embodiments, the predetermined time point is 0, 1, 2, or 3 months. 
         [0118]    In one or more embodiments, contacting the mammalian cells in step (b) comprises incubating monocytic cell line cells with an amount of the glatiramer acetate related drug substance or drug product of step (a); and wherein step (c) comprises determining the level of expression of at least one gene selected from the group consisting of Gene Group 1; ii) determining the level of expression of at least one gene selected from the group consisting of Gene Group 2; iii) determining the level of expression of at least one gene selected from the group consisting of Gene Group 3; iv) determining the level of expression of at least one gene selected from the group consisting of Gene Group 4; v) determining the level of expression of at least one gene selected from the group consisting of Gene Group 5; vi) determining the level of expression of at least one gene selected from the group consisting of Gene Group 6; vii) determining the level of expression of at least one gene selected from the group consisting of Gene Group 7; viii) determining the level of expression of at least one gene selected from the group consisting of Gene Group 8; ix) determining the level of expression of at least one gene selected from the group consisting of Gene Group 9; x) determining the level of expression of at least one gene selected from the group consisting of Gene Group 10; xvii) determining the level of expression of at least one gene selected from the group consisting of Gene Group 17; xviii) determining the level of expression of at least one gene selected from the group consisting of Gene Group 18; xix) determining the level of expression of at least one gene selected from the group consisting of Gene Group 19; xx) determining the level of expression of at least one gene selected from the group consisting of Gene Group 20; xxi) determining the level of expression of at least one gene selected from the group consisting of Gene Group 21; xxii) determining the level of expression of at least one gene selected from the group consisting of Gene Group 22; xxiii) determining the level of expression of at least one gene selected from the group consisting of Gene Group 23; xxiv) determining the level of expression of at least one gene selected from the group consisting of Gene Group 24; xxv) determining the level of expression of at least one gene selected from the group consisting of Gene Group 25; xxvi) determining the level of expression of at least one gene selected from the group consisting of Gene Group 26; xxix) determining the level of expression of at least one gene selected from the group consisting of Gene Group 29; or xxx) determining the level of expression of at least one gene selected from the group consisting of Gene Group 30, thereby characterizing the glatiramer acetate related drug substance or drug product of step (a). 
         [0119]    In one or more embodiments, contacting the mammalian cells in step (b) comprises incubating monocytic cell line cells with an amount of the glatiramer acetate related drug substance or drug product of step (a); and wherein step (c) comprises i) determining the level of expression of at least one gene selected from the group consisting of Gene Group 2; ii) determining the level of expression of at least one gene selected from the group consisting of Gene Group 3; iii) determining the level of expression of at least one gene selected from the group consisting of Gene Group 4; iv) determining the level of expression of at least one gene selected from the group consisting of Gene Group 5; v) determining the level of expression of at least one gene selected from the group consisting of Gene Group 6; vi) determining the level of expression of at least one gene selected from the group consisting of Gene Group 7; or, vii) determining the level of expression of at least one gene selected from the group consisting of Gene Group 8; ix) determining the level of expression of at least one gene selected from the group consisting of Gene Group 9; x) determining the level of expression of at least one gene selected from the group consisting of Gene Group 10; xvii) determining the level of expression of at least one gene selected from the group consisting of Gene Group 17; xviii) determining the level of expression of at least one gene selected from the group consisting of Gene Group 18; xix) determining the level of expression of at least one gene selected from the group consisting of Gene Group 19; xx) determining the level of expression of at least one gene selected from the group consisting of Gene Group 20; xxi) determining the level of expression of at least one gene selected from the group consisting of Gene Group 21; xxii) determining the level of expression of at least one gene selected from the group consisting of Gene Group 22; xxiii) determining the level of expression of at least one gene selected from the group consisting of Gene Group 23; xxiv) determining the level of expression of at least one gene selected from the group consisting of Gene Group 24; xxv) determining the level of expression of at least one gene selected from the group consisting of Gene Group 25; xxvi) determining the level of expression of at least one gene selected from the group consisting of Gene Group 26; xxix) determining the level of expression of at least one gene selected from the group consisting of Gene Group 29; or xxx) determining the level of expression of at least one gene selected from the group consisting of Gene Group 30, thereby characterizing the glatiramer acetate related drug substance or drug product of step a). 
         [0120]    In one or more embodiments of the present invention, the mammalian cells are THP-1 cells. 
         [0121]    In one or more embodiments of the present invention, contacting the mammalian cells in step (b) comprises i) immunizing a mammal with a predetermined amount of glatiramer acetate related drug substance or drug product, ii) preparing a culture of cells from the mammal of step i) at one or more predetermined time points after immunization, and iii) incubating cells from the culture of cells obtained from the mammal with an amount of the glatiramer acetate related drug substance or drug product of step (a); and wherein step (c) comprises i) determining the level of expression of at least one gene selected from the group consisting of Gene Group 1; xi) determining the level of expression of at least one gene selected from the group consisting of Gene Group 11; xii) determining the level of expression of at least one gene selected from the group consisting of Gene Group 12; xiii) determining the level of expression of at least one gene selected from the group consisting of Gene Group 13; xiv) determining the level of expression of at least one gene selected from the group consisting of Gene Group 14; xv) determining the level of expression of at least one gene selected from the group consisting of Gene Group 15; or xvi) determining the level of expression of at least one gene selected from the group consisting of Gene Group 16, thereby characterizing the glatiramer acetate related drug substance or drug product of step (a). 
         [0122]    In one or more embodiments of the present invention, the glatiramer acetate related drug substance or drug product of step (iii) is the same glatiramer acetate related drug substance or drug product of step (i). 
         [0123]    In one or more embodiments of the present invention, the glatiramer acetate related drug substance or drug product of step (iii) is a different glatiramer acetate related drug substance or drug product of step (i). 
         [0124]    In one or more embodiments of the present invention, the incubation is for about 24 hours, for about 12 hours, or for about 6 hours. 
         [0125]    In one or more embodiments of the present invention, the predetermined time point after immunization is 3 days. 
         [0126]    In one or more embodiments of the present invention, the contacting of step (b) is in a cell culture. 
         [0127]    In one or more embodiments of the present invention, the culture is a primary culture. 
         [0128]    In one or more embodiments of the present invention, the contacting of step (b) is in a mammal. 
         [0129]    In one or more embodiments of the present invention, the mammal is a rodent or human. 
         [0130]    In one or more embodiments of the present invention, the glatiramer acetate related drug substance or drug product is other than glatiramer acetate drug substance or drug product. 
         [0131]    In one or more embodiments of the present invention, the cell is of a type i) selected from the group of cell types consisting of FoxP3+ T cells, regulatory T cells, natural killer T cells, T helper 2 cells, CD8+ T cells, CD4+ T cells, B cells, macrophage cells, monocyte cells, eosinophils, dendritic cells, granulocytes, megakaryocytes, and myeloid progenitors; ii) selected from the group of cell types identified in Table 9; iii) selected from the group of cell types identified in Table 10; or iv) selected from the group of cell types identified in Table 11. 
         [0132]    In one or more embodiments of the present invention, the process of characterizing two or more glatiramer acetate related drug substances or drug products further comprises obtaining characteristics of each of the glatiramer acetate related drug substances or drug products; and comparing the characteristics of the drug related substances or drug products, thereby discriminating between glatiramer acetate related drug substances or drug products. 
         [0133]    In one or more embodiments of the present invention, the mammal is a rodent or human. 
         [0134]    In one or more embodiments of the present invention, the level of expression is determined in hematological cells. 
         [0135]    In one or more embodiments of the present invention, the level of expression is determined in splenocytes. 
         [0136]    In one or more embodiments of the present invention, the level of expression is determined in monocytes. 
         [0137]    In one or more embodiments of the present invention, the monocytes are THP-1. 
         [0138]    In one or more embodiments of the present invention, the level of expression is determined in peripheral blood mononuclear cells. 
         [0139]    In one or more embodiments of the present invention, the peripheral blood mononuclear cells are from a human. 
         [0140]    In one or more embodiments of the present invention, the human has previously been treated with a glatiramer acetate related drug substance or drug product. 
         [0141]    In one or more embodiments of the present invention, the human is a naïve human. 
         [0142]    In one or more embodiments of the present invention, the human is a glatiramoid naïve human. 
         [0143]    In one or more embodiments of the present invention, the human is afflicted with RRMS. 
         [0144]    In one or more embodiments of the present invention, the rodent is a mouse. 
         [0145]    In one or more embodiments of the present invention, the mouse is a female (SJL X BALB/C) F1 mouse. 
         [0146]    In one or more embodiments of the present invention, the mouse is about 8 to 12 weeks old. 
         [0147]    In one or more embodiments of the present invention, the primary culture is a culture of spleen cells. 
         [0148]    In some embodiments of the present invention, the primary culture is a culture of lymph node cells. 
         [0149]    In some embodiments of the present invention, the primary culture of spleen cells is prepared about 3 days after immunization. 
         [0150]    In one or more embodiments of the present invention, the glatiramer acetate related drug substance is a glatiramoid or the glatiramer acetate related drug product comprises a glatiramoid. 
         [0151]    In one or more embodiments of the present invention, the glatiramer acetate related drug substance is a glatiramoid other than glatiramer acetate related drug substance, or the glatiramer acetate related drug product comprises a glatiramoid other than glatiramer acetate drug substance. 
         [0152]    In one or more embodiments of the present invention, process for characterizing a glatiramer acetate related drug substance or drug product comprising the steps of:
   a) obtaining a batch of the glatiramer acetate related drug substance or drug product;   b) contacting a first group of mammalian cells with an amount of the glatiramer acetate related drug substance or drug product of step a);   c) contacting a second group of mammalian cells of the same type with an amount of a reference standard; and   d) determining a set of genes differentially expressed by the first group after the contacting of step (b) relative to genes expressed by the second group after the contacting of step (c),
 
thereby characterizing the glatiramer acetate related drug substance or drug product of step a).
   
 
         [0157]    In one or more embodiments of the present invention, the cells are THP-1 cells. 
         [0158]    In one or more embodiments of the present invention, the reference standard is glatiramer acetate related drug substance or drug product. 
         [0159]    In one or more embodiments of the present invention, the reference standard is mannitol 
         [0160]    In one or more embodiments of the present invention, the reference standard is medium. 
         [0161]    In one or more embodiments of the present invention, the determining step (d) comprises comparing the expression of genes expressed by the first group to the expression of genes expressed by the second group. 
         [0162]    In one or more embodiments of the present invention, the determining step (d) comprises comparing the expression of genes by bother the first group of cells and by the second group of cells to expression of the genes by the same type of cells exposed to mannitol or medium. 
         [0163]    In one or more embodiments of the present invention, process for discriminating between glatiramer acetate related drug substances or drug products comprising the step of characterizing two or more glatiramer acetate related drug substances or drug products to obtain characteristics of each of the glatiramer acetate related drug substances or drug products; and comparing the characteristics of the glatiramer acetate related drug substances or drug products, thereby discriminating between glatiramer acetate related drug substances or drug products. 
         [0164]    In some embodiments of the present invention in a process for producing a drug product comprising a glatiramer acetate related drug substance which involves an array of testing, the improvement comprising including in the array of testing the steps of:
   a) characterizing the glatiramer acetate related drug substance according to the process of any one of the above characterization methods; and   b) i) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 1 is not substantially identical to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug substance under the same conditions; ii) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 2 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; iii) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 3 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; iv) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 4 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; v) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 5 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; vi) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 6, is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; vii) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 7, is upregulated to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug substance under the same conditions; viii) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 8, is downregulated to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug substance under the same conditions; or ix) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 9 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; x) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 10 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xi) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 11 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xii) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 12 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xiii) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 13 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xiv) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 14 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xv) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 15 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xvi) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 16 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xvii) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 17 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xviii) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 18 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xix) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 19 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xx) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 20 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxi) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 21 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxii) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 22 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxiii) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 23 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxiv) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 24 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxv) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 25 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxvi) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 26 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxix) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 29 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; or xxx) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 30 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions.   
 
         [0167]    In one or more embodiments of the present invention, in the process for producing a drug product comprising a glatiramer acetate related drug substance which involves an array of testing, the characterizing the glatiramer acetate related drug substance further comprises including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 1 is not substantially identical to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug substance under the same conditions. 
         [0168]    In one or more embodiments of the present invention, in the process for producing a drug product comprising a glatiramer acetate related drug substance which involves an array of testing, the characterizing the glatiramer acetate related drug substance further comprises including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of ABCF2, ABI2, ACP6, AFG3L2, ALMS1, ARPC4, CALM3, CCDC64, CD84, CDC6, CHAF1A, CLU, COX11, DLGAP1, DTX4, FAM49B, FHL1, FNTB, GYPC, HFE, LPHN1, OLAH, PATZ1, PDK1, POLI, REEP5, RPS6KA2, SEC31A, SETBP1, SNRPA1, SYNCRIP, TNFSF9, TOMM40, TPM1, TSPAN13, UBAP2, VAV3, VDAC2, and ZFAND6 is not substantially identical to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug substance under the same conditions. 
         [0169]    In one or more embodiments of the present invention, in the process for producing a drug product comprising a glatiramer acetate related drug substance which involves an array of testing, the characterizing the glatiramer acetate related drug substance further comprises including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 2 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions. 
         [0170]    In one or more embodiments of the present invention, in the process for producing a drug product comprising a glatiramer acetate related drug substance which involves an array of testing, the characterizing the glatiramer acetate related drug substance further comprises including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 3 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions. 
         [0171]    In one or more embodiments of the present invention, in the process for producing a drug product comprising a glatiramer acetate related drug substance which involves an array of testing, the characterizing the glatiramer acetate related drug substance further comprises including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 4 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions. 
         [0172]    In one or more embodiments of the present invention, in the process for producing a drug product comprising a glatiramer acetate related drug substance which involves an array of testing, the characterizing the glatiramer acetate related drug substance further comprises including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 5 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions. 
         [0173]    In one or more embodiments of the present invention, in the process for producing a drug product comprising a glatiramer acetate related drug substance which involves an array of testing, the characterizing the glatiramer acetate related drug substance further comprises including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 6 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions. 
         [0174]    In one or more embodiments of the present invention, in the process for producing a drug product comprising a glatiramer acetate related drug substance which involves an array of testing, the characterizing the glatiramer acetate related drug substance further comprises i) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of ABI2, ARPC4, CD84, CLU, HFE, and IL10 is upregulated relative to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug substance under the same conditions; or ii) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of ABCF2, ACP6, AFG3L2, CHAF1A, COX11, LPHN1, NACA, OLAH, POLI, SEC31A, SNRPA1, SYNCRIP, TNFSF9, TOMM40, TSHZ1, TSPAN13, UBAP2, VDAC2, and TSHZ1 is downregulated relative to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug substance under the same conditions. 
         [0175]    In one or more embodiments of the present invention, in the process for producing a drug product comprising a glatiramer acetate related drug substance which involves an array of testing, the characterizing the glatiramer acetate related drug substance further comprises, if, one or more genes selected from the group consisting of ABI2, ARPC4, HFE, and IL10 is upregulated relative to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug substance under the same conditions, then including the batch of the glatiramer acetate related drug substance in the production of the drug product. 
         [0176]    In one or more embodiments of the present invention, in the process for producing a drug product comprising a glatiramer acetate related drug substance which involves an array of testing, the characterizing the glatiramer acetate related drug substance further comprises, if, one or more genes selected from the group consisting of ACP6, LPHN1, POLI, SEC31A, SYNCRIP, and TSHZ1 is downregulated relative to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug substance under the same conditions, then including the batch of the glatiramer acetate related drug substance in the production of the drug product. 
         [0177]    In one or more embodiments of the present invention, in the process for producing a drug product comprising a glatiramer acetate related drug substance which involves an array of testing, the characterizing the glatiramer acetate related drug substance further comprises i) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of CCL2, CCL5, MMP1, MMP9, CXCL10, CARD15, CD14, ICAM1, BIRC3, THBD, NFKBIA, IL10, PRDM1 is substantially identical to the level of expression by the same type of cells in the presence of glatiramer acetate drug substance under the same conditions; ii) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of CISH and HSPD1 is substantially identical to the level of expression by the same type of cells in the presence of glatiramer acetate drug substance under the same conditions; iii) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of CC124, CCR1, CSF1R, CX3CR1, IL27, IFNGR1, IL2RG, and IL7R is not substantially identical to the level of expression by the same type of cells in the absence of the glatiramer acetate drug related substance under the same conditions; iv) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of PGRMC1 is upregulated or substantially identical to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug substance under the same conditions; v) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of MMP14 is substantially identical to the level of expression by the same type of cells in the presence of glatiramer acetate drug substance under the same conditions; vi) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of IL1RN is upregulated to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug substance under the same conditions; or vii) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of IL1B is substantially identical to the level of expression by the same type of cells in the presence of glatiramer acetate drug substance under the same conditions. 
         [0178]    In one or more embodiments of the present invention, in the process for producing a drug product comprising a glatiramer acetate related drug substance which involves an array of testing, the characterizing the glatiramer acetate related drug substance further comprises including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 5 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions. 
         [0179]    In one or more embodiments of the present invention, in the process for producing a drug product comprising a glatiramer acetate related drug substance which involves an array of testing, the characterizing the glatiramer acetate related drug substance further comprises including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 6 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions. 
         [0180]    In one or more embodiments of the present invention, in the process for producing a drug product comprising a glatiramer acetate related drug substance which involves an array of testing, the characterizing the glatiramer acetate related drug substance further comprises including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 7, is upregulated to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug substance under the same conditions. 
         [0181]    In one or more embodiments of the present invention, in the process for producing a drug product comprising a glatiramer acetate related drug substance which involves an array of testing, the characterizing the glatiramer acetate related drug substance further comprises including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 8, is downregulated to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug substance under the same conditions. 
         [0182]    In some embodiments of the present invention in a process for releasing a drug product comprising a glatiramer acetate related drug substance, which process involves an array of testing, the improvement comprising including in the array of testing the steps of:
   a) characterizing the glatiramer acetate related drug product according to the process of any one of the above characterization methods; and   b) i) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 1 is not substantially identical to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug product under the same conditions; ii) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 2 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug product under the same conditions; iii) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 3 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug product under the same conditions; iv) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 4 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug product under the same conditions; v) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 5 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug product under the same conditions; vi) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 6, is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug product under the same conditions; vii) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 7, is upregulated to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug substance under the same conditions; viii) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 8, is downregulated to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug substance under the same conditions, ix) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 9 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug product under the same conditions; x) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 10 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug product under the same conditions; xi) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 11 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xii) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 12 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xiii) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 13 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xiv) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 14 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xv) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 15 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xvi) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 16 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xvii) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 17 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xviii) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 18 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xix) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 19 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xx) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 20 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxi) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 21 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxii) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 22 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxiii) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 23 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxiv) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 24 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxv) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 25 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxvi) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 26 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxix) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 29 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; or xxx) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 30 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions.   
 
         [0185]    In one or more embodiments of the present invention, in the process for releasing a drug product comprising a glatiramer acetate related drug substance which involves an array of testing, the characterizing the glatiramer acetate related drug product further comprises releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 1 is not substantially identical to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug product under the same conditions. 
         [0186]    In one or more embodiments of the present invention, in the process for releasing a drug product comprising a glatiramer acetate related drug substance which involves an array of testing, the characterizing the glatiramer acetate related drug product further comprises releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of ABCF2, ABI2, ACP6, AFG3L2, ALMS1, ARPC4, CALM3, CCDC64, CD84, CDC6, CHAF1A, CLU, COX11, DLGAP1, DTX4, FAM49B, FHL1, FNTB, GYPC, HFE, LPHN1, OLAH, PATZ1, PDK1, POLI, REEP5, RPS6KA2, SEC31A, SETBP1, SNRPA1, SYNCRIP, TNFSF9, TOMM40, TPM1, TSPAN13, UBAP2, VAV3, VDAC2, and ZFAND6 is not substantially identical to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug product under the same conditions. 
         [0187]    In one or more embodiments of the present invention, in the process for releasing a drug product comprising a glatiramer acetate related drug substance which involves an array of testing, the characterizing the glatiramer acetate related drug product further comprises releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 2 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug product under the same conditions. 
         [0188]    In one or more embodiments of the present invention, in the process for releasing a drug product comprising a glatiramer acetate related drug substance which involves an array of testing, the characterizing the glatiramer acetate related drug product further comprises releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 3 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug product under the same conditions. 
         [0189]    In one or more embodiments of the present invention, in the process for releasing a drug product comprising a glatiramer acetate related drug substance which involves an array of testing, the characterizing the glatiramer acetate related drug product further comprises releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 4 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug product under the same conditions. 
         [0190]    In one or more embodiments of the present invention, in the process for releasing a drug product comprising a glatiramer acetate related drug substance which involves an array of testing, the characterizing the glatiramer acetate related drug product further comprises releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 5, is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug product under the same conditions. 
         [0191]    In one or more embodiments of the present invention, in the process for releasing a drug product comprising a glatiramer acetate related drug substance which involves an array of testing, the characterizing the glatiramer acetate related drug product further comprises releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 6 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug product under the same conditions. 
         [0192]    In one or more embodiments of the present invention, in the process for releasing a drug product comprising a glatiramer acetate related drug substance which involves an array of testing, the characterizing the glatiramer acetate related drug substance further comprises i) releasing the batch of the glatiramer acetate related drug product if the level of expression of one of more genes selected from the group consisting of ABI2, ARPC4, CD84, CLU, HFE, and IL10 is upregulated relative to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug product under the same conditions; or ii) releasing the batch of the glatiramer acetate related drug product if the level of expression of one of more genes selected from the group consisting of ABCF2, ACP6, AFG3L2, CHAF1A, COX11, LPHN1, NACA, OLAH, POLI, SEC31A, SNRPA1, SYNCRIP, TNFSF9, TOMM40, TSHZ1, TSPAN13, UBAP2, VDAC2, and TSHZ1 is downregulated relative to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug product under the same conditions. 
         [0193]    In one or more embodiments of the present invention, in the process for releasing a drug product comprising a glatiramer acetate related drug substance which involves an array of testing, the characterizing the glatiramer acetate related drug substance further comprises, if, one or more genes selected from the group consisting of ABI2, ARPC4, HFE, and IL10 is upregulated relative to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug product under the same conditions, then releasing the batch of the glatiramer acetate related drug product. 
         [0194]    In one or more embodiments of the present invention, in the process for releasing a drug product comprising a glatiramer acetate related drug substance which involves an array of testing, the characterizing the glatiramer acetate related drug product further comprises, if, one or more genes selected from the group consisting of ACP6, LPHN1, POLI, SEC31A, SYNCRIP, and TSHZ1 is downregulated relative to the level of expression by the same type of cells in the presence of the glatiramer acetate drug product under the same conditions, then releasing the batch of the glatiramer acetate related drug product. 
         [0195]    In one or more embodiments of the present invention, in the process for releasing a drug product comprising a glatiramer acetate related drug substance which involves an array of testing, the characterizing the glatiramer acetate related drug product further comprises i) releasing the batch of the glatiramer acetate related drug product if the level of expression of one of more genes selected from the group consisting of CCL2, CCL5, MMP1, MMP9, CXCL10, CARD15, CD14, ICAM1, BIRC3, THBD, NFKBIA, IL10, PRDM1 is substantially identical to the level of expression by the same type of cells in the presence of glatiramer acetate drug substance under the same conditions; ii) releasing the batch of the glatiramer acetate related drug product if the level of expression of one of more genes selected from the group consisting of CISH and HSPD1 is substantially identical to the level of expression by the same type of cells in the presence of glatiramer acetate drug substance under the same conditions; iii) releasing the batch of the glatiramer acetate related drug product if the level of expression of one of more genes selected from the group consisting of CC124, CCR1, CSF1R, CX3CR1, IL27, IFNGR1, IL2RG, and IL7R is not substantially identical to the level of expression by the same type of cells in the absence of the glatiramer acetate drug related substance under the same conditions; iv) releasing the batch of the glatiramer acetate related drug product if the level of expression of PGRMC1 is upregulated or substantially identical to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug substance under the same conditions; v) releasing the batch of the glatiramer acetate related drug product if the level of expression of MMP14 is substantially identical to the level of expression by the same type of cells in the presence of glatiramer acetate drug substance under the same conditions; vi) releasing the batch of the glatiramer acetate related drug product if the level of expression of IL1RN is upregulated to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug substance under the same conditions; or vii) releasing the batch of the glatiramer acetate related drug product if the level of expression of IL1B is substantially identical to the level of expression by the same type of cells in the presence of glatiramer acetate drug substance under the same conditions. 
         [0196]    In one or more embodiments of the present invention, in the process for releasing a drug product comprising a glatiramer acetate related drug substance which involves an array of testing, the characterizing the glatiramer acetate related drug product further comprises releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 5, is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug product under the same conditions. 
         [0197]    In one or more embodiments of the present invention, in the process for releasing a drug product comprising a glatiramer acetate related drug substance which involves an array of testing, the characterizing the glatiramer acetate related drug product further comprises releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 6 is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug product under the same conditions. 
         [0198]    In one or more embodiments of the present invention, in the process for releasing a drug product comprising a glatiramer acetate related drug substance which involves an array of testing, the characterizing the glatiramer acetate related drug product further comprises releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 7, is upregulated to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug substance under the same conditions. 
         [0199]    In one or more embodiments of the present invention, in the process for releasing a drug product comprising a glatiramer acetate related drug substance which involves an array of testing, the characterizing the glatiramer acetate related drug product further comprises releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 8, is downregulated to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug substance under the same conditions. 
         [0200]    In one or more embodiments of the present invention, a glatiramer acetate related drug product produced by a process of the present invention, wherein the glatiramer acetate related drug product is other than glatiramer acetate drug product. 
         [0201]    In one or more embodiments of the present invention, a glatiramer acetate related drug product other than glatiramer acetate drug product which is capable of inducing a level of expression of ABCF2, ABI2, ACP6, AFG3L2, ALMS1, ARPC4, CALM3, CCDC64, CD84, CDC6, CHAF1A, CLU, COX11, DLGAP1, DTX4, FAM49B, FHL1, FNTB, GYPC, HFE, LPHN1, OLAH, PATZ1, PDK1, POLI, REEP5, RPS6KA2, SEC31A, SETBP1, SNRPA1, SYNCRIP, TNFSF9, TOMM40, TPM1, TSPAN13, UBAP2, VAV3, VDAC2, and ZFAND6 that is not substantially identical to the level of expression of the genes induced in the same tpe of cells and under the same conditions in the absence of the glatiramer acetate related drug product. 
         [0202]    In one or more embodiments of the present invention, a glatiramer acetate related drug product, wherein the glatiramer acetate related drug product is capable of inducing a level of expression of Gene Group 1. 
         [0203]    In one or more embodiments of the present invention, the glatiramer acetate related drug product, which is capable of upregulating genes ABI2, ARPC4, HFE, and IL10 relative to the level of expression of the genes in the same type of cells and under the same conditions in the absence of the glatiramer acetate related drug product, and capable of downregulating genes ACP6, LPHN1, POLI, SEC31A, SYNCRIP, and TSHZ1 relative to the level of expression of the genes in the same type of cells and under the same conditions in the absence of the glatiramer acetate related drug product. 
         [0204]    In one or more embodiments of the present invention, a glatiramer acetate related drug product other than glatiramer acetate drug product which is capable of inducing a level of expression of Gene Group 7 and Gene Group 8, that is not substantially identical to the level of expression of the genes induced in the same type of cells and under the same conditions in the absence of the glatiramer acetate related drug product. 
         [0205]    In one or more embodiments of the present invention, the glatiramer acetate related drug product, which is capable of upregulating genes Gene Group 7, relative to the level of expression of the genes in the same type of cells and under the same conditions in the absence of the glatiramer acetate related drug product, and capable of downregulating genes Gene Group 8 relative to the level of expression of the genes in the same type of cells and under the same conditions in the absence of the glatiramer acetate related drug product 
         [0206]    In some embodiments of the present invention, the process further comprises i) determining the one or more proteins produced by each of the one of more genes selected in step c); and ii) determining protein level expression for each protein in step i). 
         [0207]    In some embodiments of the present invention, the process further comprises i) determining the one or more proteins produced by each of the one of more genes selected in step b); and ii) determining protein level expression for each protein in step i). 
         [0208]    In some embodiments of the present invention, the process further comprises determining the set of proteins produced by each gene of the set of genes in step d). 
         [0209]    In some embodiments of the present invention, in a process for characterizing a glatiramer acetate related drug substance or drug product comprising the steps of:
   a) obtaining a batch of the glatiramer acetate related drug substance or drug product;   b) contacting mammalian cells with an amount of the glatiramer acetate related drug substance or drug product of step a); and   c) xxii) determining the protein level expression of at least one protein selected from the group consisting of Protein Group A; xxiii) determining the protein level expression of at least one protein selected from the group consisting of Protein Group B; xxiv) determining the protein level expression of at least one protein selected from the group consisting of Protein Group C; xxv) determining the protein level expression of at least one protein selected from the group consisting of Protein Group D; xxvi) determining the protein level expression of at least one protein selected from the group consisting of Protein Group E; xxvii) determining the protein level expression of at least one protein selected from the group consisting of Protein Group F; or xxviii) determining the protein level expression of at least one protein selected from the group consisting of Protein Group G,
 
thereby characterizing the glatiramer acetate related drug substance or drug product of step a).
   
 
         [0213]    In some embodiments of the present invention, in a process for characterizing a glatiramer acetate related drug substance or drug product comprising the steps of:
   a) obtaining a batch of the glatiramer acetate related drug substance or drug product;   b) contacting mammalian cells with an amount of the glatiramer acetate related drug substance or drug product of step a); and   c) i) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 1; ii) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 2, wherein if IL1B, IL10, or MMP9 is the at least one gene selected in part (c)(ii), then selecting at least a second different gene from the group other than IL1B, IL10, or MMP9; iii) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 3; iv) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 4; v) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 5; vi) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 6; vii) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 7; viii) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 8; ix) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 9; x) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 10; xi) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 11; xii) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 12; x) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 13; xiv) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 14; xv) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 15; xvi) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 16; xvii) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 17; xviii) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 18; xix) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 19; xx) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 20; xxi) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 21; xxii) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 22; xxiii) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 23; xxiv) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 24; xxv) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 25; xxvi) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 26; xxix) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 29; or xxx) determining the protein level expression of at least one protein produced by a gene selected from the group consisting of Gene Group 30,
 
thereby characterizing the glatiramer acetate related drug substance or drug product of step a).
   
 
         [0217]    In some embodiments of the present invention the process, wherein contacting the mammalian cells in step (b) comprises incubating monocytic cell line cells with an amount of the glatiramer acetate related drug substance or drug product of step (a); and wherein step (c) comprises xxii) determining the protein level expression of at least one protein selected from the group consisting of Protein Group A; xxiii) determining the protein level expression of at least one protein selected from the group consisting of Protein Group B; xxiv) determining the protein level expression of at least one protein selected from the group consisting of Protein Group C; xxv) determining the protein level expression of at least one protein selected from the group consisting of Protein Group D; xxvi) determining the protein level expression of at least one protein selected from the group consisting of Protein Group E; xxvii) determining the protein level expression of at least one protein selected from the group consisting of Protein Group F; or xxviii) determining the protein level expression of at least one protein selected from the group consisting of Protein Group G, thereby characterizing the glatiramer acetate related drug substance or drug product of step (a). 
         [0218]    In some embodiments of the present invention, the process wherein the mammalian cells are THP-1 cells. 
         [0219]    In some embodiments of the present invention, the process, wherein the incubation is for about 24 hours. 
         [0220]    In some embodiments of the present invention, the process, wherein contacting the mammalian cells in step (b) comprises i) immunizing a mammal with a predetermined amount of glatiramer acetate related drug substance or drug product, ii) preparing a culture of cells from the mammal of step i) at one or more predetermined time points after immunization, and iii) incubating cells from the culture of cells obtained from the mammal with an amount of the glatiramer acetate related drug substance or drug product of step (a), thereby characterizing the glatiramer acetate related drug substance or drug product of step (a). 
         [0221]    In some embodiments of the present invention, the process, wherein the glatiramer acetate related drug substance or drug product of step (iii) is the same glatiramer acetate related drug substance or drug product of step (i). 
         [0222]    In some embodiments of the present invention, the process, wherein the glatiramer acetate related drug substance or drug product of step (iii) is a different glatiramer acetate related drug substance or drug product of step (i). 
         [0223]    In some embodiments of the present invention, in a process for producing a drug product comprising a glatiramer acetate related drug substance which involves an array of testing, the improvement comprising including in the array of testing the steps of:
   a) characterizing the glatiramer acetate related drug substance according to the process of any one of the above characterization methods; and   b) xxii) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more proteins selected from the group consisting of Protein Group A is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate related drug substance under the same conditions; xxiii) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more proteins selected from the group consisting of Protein Group B is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate related drug substance under the same conditions; xxiv) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more proteins selected from the group consisting of Protein Group C is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate related drug substance under the same conditions; xxv) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more proteins selected from the group consisting of Protein Group D is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate related drug substance under the same conditions; xxvi) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more proteins selected from the group consisting of Protein Group E is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate related drug substance under the same conditions; xxvii) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more proteins selected from the group consisting of Protein Group F is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate related drug substance under the same conditions; or xxviii) including the batch of the glatiramer acetate related drug substance in the production of the drug product if the level of expression of one or more proteins selected from the group consisting of Protein Group G is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate related drug substance under the same conditions.   
 
         [0226]    In some embodiments of the present invention, in a process for releasing a drug product comprising a glatiramer acetate related drug substance, which process involves an array of testing, the improvement comprising including in the array of testing the steps of:
   a) characterizing the glatiramer acetate related drug product according to the process of any one of the above characterization methods; and   b) xxii) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more proteins selected from the group consisting of Protein Group A is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate related drug product under the same conditions; xxiii) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more proteins selected from the group consisting of Protein Group B is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate related drug product under the same conditions; xxiv) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more proteins selected from the group consisting of Protein Group C is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate related drug product under the same conditions; xxv) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more proteins selected from the group consisting of Protein Group D is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate related drug product under the same conditions; xxvi) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more proteins selected from the group consisting of Protein Group E is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate related drug product under the same conditions; xxvii) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more proteins selected from the group consisting of Protein Group F is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate related drug product under the same conditions; or xxviii) releasing the batch of the glatiramer acetate related drug product if the level of expression of one or more proteins selected from the group consisting of Protein Group G is substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate related drug product under the same conditions.   
 
         [0229]    In some embodiments of the present invention, in a process for discriminating between glatiramer acetate related drug substances or drug products comprising the steps of:
   a) characterizing one or more glatiramer acetate related drug substances or drug products according to the process of any one of the above characterization methods to obtain characteristics of each of the glatiramer acetate related drug substances or drug products;   b) obtaining characteristics of a glatiramer acetate drug substance or drug product; and   c) comparing the characteristics of the glatiramer acetate related drug substances or drug products obtained in steps a) and b),
 
thereby discriminating between glatiramer acetate related drug substances or drug products.
   
 
       ADDITIONAL EMBODIMENTS OF THE INVENTION 
       [0233]    In a process for producing a drug product comprising a glatiramer acetate related drug substance, the improvement comprising the steps of:
   a) characterizing the glatiramer acetate related drug substance according to the process of any one of the above characterization methods; and   b) i) discarding the batch of the glatiramer acetate related drug substance as unacceptable for inclusion in the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 1 is substantially identical to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug substance under the same conditions; ii) discarding the batch of the glatiramer acetate related drug substance as unacceptable for inclusion in the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 2 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; iii) discarding the batch of the glatiramer acetate related drug substance as unacceptable for inclusion in the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 3 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; iv) discarding the batch of the glatiramer acetate related drug substance as unacceptable for inclusion in the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 4 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; v) discarding the batch of the glatiramer acetate related drug substance as unacceptable for inclusion in the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 5 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; vi) discarding the batch of the glatiramer acetate related drug substance as unacceptable for inclusion in the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 6, is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; vii) discarding the batch of the glatiramer acetate related drug substance as unacceptable for inclusion in the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 7, is downregulated or substantially identical to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug substance under the same conditions; viii) discarding the batch of the glatiramer acetate related drug substance as unacceptable for inclusion in the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 8, is upregulated or substantially identical to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug substance under the same conditions; ix) discarding the batch of the glatiramer acetate related drug substance as unacceptable for inclusion in the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 9 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; x) discarding the batch of the glatiramer acetate related drug substance as unacceptable for inclusion in the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 10 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xi) discarding the batch of the glatiramer acetate related drug substance as unacceptable for inclusion in the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 11 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xii) discarding the batch of the glatiramer acetate related drug substance as unacceptable for inclusion in the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 12 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xiii) discarding the batch of the glatiramer acetate related drug substance as unacceptable for inclusion in the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 13 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xiv) discarding the batch of the glatiramer acetate related drug substance as unacceptable for inclusion in the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 14 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xv) discarding the batch of the glatiramer acetate related drug substance as unacceptable for inclusion in the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 15 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xvi) discarding the batch of the glatiramer acetate related drug substance as unacceptable for inclusion in the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 16 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xvii) discarding the batch of the glatiramer acetate related drug substance as unacceptable for inclusion in the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 17 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xviii) discarding the batch of the glatiramer acetate related drug substance as unacceptable for inclusion in the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 18 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xix) discarding the batch of the glatiramer acetate related drug substance as unacceptable for inclusion in the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 19 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xx) discarding the batch of the glatiramer acetate related drug substance as unacceptable for inclusion in the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 20 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxi) discarding the batch of the glatiramer acetate related drug substance as unacceptable for inclusion in the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 21 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxii) discarding the batch of the glatiramer acetate related drug substance as unacceptable for inclusion in the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 22 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxiii) discarding the batch of the glatiramer acetate related drug substance as unacceptable for inclusion in the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 23 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxiv) discarding the batch of the glatiramer acetate related drug substance as unacceptable for inclusion in the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 24 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxv) discarding the batch of the glatiramer acetate related drug substance as unacceptable for inclusion in the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 25 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxvi) discarding the batch of the glatiramer acetate related drug substance as unacceptable for inclusion in the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 26 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxix) discarding the batch of the glatiramer acetate related drug substance as unacceptable for inclusion in the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 29 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; or xxx) discarding the batch of the glatiramer acetate related drug substance as unacceptable for inclusion in the drug product if the level of expression of one or more genes selected from the group consisting of Gene Group 30 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions.   
 
         [0236]    In a process for releasing a drug product comprising a glatiramer acetate related drug substance, the improvement comprising the steps of:
   a) characterizing the glatiramer acetate related drug product according to the process of any one of the above characterization methods; and   b) i) discarding the batch of the glatiramer acetate related drug product as unacceptable for release if the level of expression of one or more genes selected from the group consisting of Gene Group 1 is substantially identical to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug product under the same conditions; ii) discarding the batch of the glatiramer acetate related drug product as unacceptable for release if the level of expression of one or more genes selected from the group consisting of Gene Group 2 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug product under the same conditions; iii) discarding the batch of the glatiramer acetate related drug product as unacceptable for release if the level of expression of one or more genes selected from the group consisting of Gene Group 3 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug product under the same conditions; iv) discarding the batch of the glatiramer acetate related drug product as unacceptable for release if the level of expression of one or more genes selected from the group consisting of Gene Group 4 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug product under the same conditions; v) discarding the batch of the glatiramer acetate related drug product as unacceptable for release if the level of expression of one or more genes selected from the group consisting of Gene Group 5, is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug product under the same conditions; vi) discarding the batch of the glatiramer acetate related drug product as unacceptable for release if the level of expression of one or more genes selected from the group consisting of Gene Group 6 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug product under the same conditions; vii) discarding the batch of the glatiramer acetate related drug product as unacceptable for release if the level of expression of one or more genes selected from the group consisting of Gene Group 7, is downregulated or substantially identical to the level of expression by the same type of cells in the absence of glatiramer acetate drug product under the same conditions; viii) discarding the batch of the glatiramer acetate related drug product as unacceptable for release if the level of expression of one or more genes selected from the group consisting of Gene Group 8, is upregulated or substantially identical to the level of expression by the same type of cells in the absence of glatiramer acetate drug product under the same conditions; ix) discarding the batch of the glatiramer acetate related drug product as unacceptable for release if the level of expression of one or more genes selected from the group consisting of Gene Group 9 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug product under the same conditions; x) discarding the batch of the glatiramer acetate related drug product as unacceptable for release if the level of expression of one or more genes selected from the group consisting of Gene Group 10 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug product under the same conditions; xi) discarding the batch of the glatiramer acetate related drug product as unacceptable for release if the level of expression of one or more genes selected from the group consisting of Gene Group 11 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xii) discarding the batch of the glatiramer acetate related drug product as unacceptable for release if the level of expression of one or more genes selected from the group consisting of Gene Group 12 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xiii) discarding the batch of the glatiramer acetate related drug product as unacceptable for release if the level of expression of one or more genes selected from the group consisting of Gene Group 13 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xiv) discarding the batch of the glatiramer acetate related drug product as unacceptable for release if the level of expression of one or more genes selected from the group consisting of Gene Group 14 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xv) discarding the batch of the glatiramer acetate related drug product as unacceptable for release if the level of expression of one or more genes selected from the group consisting of Gene Group 15 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xvi) discarding the batch of the glatiramer acetate related drug product as unacceptable for release if the level of expression of one or more genes selected from the group consisting of Gene Group 16 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xvii) discarding the batch of the glatiramer acetate related drug product as unacceptable for release if the level of expression of one or more genes selected from the group consisting of Gene Group 17 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xviii) discarding the batch of the glatiramer acetate related drug product as unacceptable for release if the level of expression of one or more genes selected from the group consisting of Gene Group 18 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xix) discarding the batch of the glatiramer acetate related drug product as unacceptable for release if the level of expression of one or more genes selected from the group consisting of Gene Group 19 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xx) discarding the batch of the glatiramer acetate related drug product as unacceptable for release if the level of expression of one or more genes selected from the group consisting of Gene Group 20 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxi) discarding the batch of the glatiramer acetate related drug product as unacceptable for release if the level of expression of one or more genes selected from the group consisting of Gene Group 21 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxii) discarding the batch of the glatiramer acetate related drug product as unacceptable for release if the level of expression of one or more genes selected from the group consisting of Gene Group 22 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxiii) discarding the batch of the glatiramer acetate related drug product as unacceptable for release if the level of expression of one or more genes selected from the group consisting of Gene Group 23 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxiv) discarding the batch of the glatiramer acetate related drug product as unacceptable for release if the level of expression of one or more genes selected from the group consisting of Gene Group 24 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxv) discarding the batch of the glatiramer acetate related drug product as unacceptable for release if the level of expression of one or more genes selected from the group consisting of Gene Group 25 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxvi) discarding the batch of the glatiramer acetate related drug product as unacceptable for release if the level of expression of one or more genes selected from the group consisting of Gene Group 26 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxix) discarding the batch of the glatiramer acetate related drug product as unacceptable for release if the level of expression of one or more genes selected from the group consisting of Gene Group 29 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; or xxx) discarding the batch of the glatiramer acetate related drug product as unacceptable for release if the level of expression of one or more genes selected from the group consisting of Gene Group 20 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions.   
 
         [0239]    In one or more embodiments of the present invention, in a process for identifying suboptimal activity of a glatiramer acetate related drug substance or drug product comprising the steps of:
   a) administering a glatiramer acetate related drug substance or drug product to a mammal;   b) characterizing the glatiramer acetate related drug substance or drug product according to the process of any one of the above characterization methods; and   c) i) identifying the glatiramer acetate related drug substance or drug product as causing a suboptimal activity if the level of expression of one or more genes selected from the group consisting of Gene Group 1 is substantially identical to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug substance or drug product under the same conditions; ii) identifying the glatiramer acetate related drug substance or drug product as causing a suboptimal activity if the level of expression of one or more genes selected from the group consisting of Gene Group 2 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate related drug substance or drug product under the same conditions; iii) identifying the glatiramer acetate related drug substance or drug product as causing a suboptimal activity if the level of expression of one or more genes selected from the group consisting of Gene Group 3 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate related drug substance or drug product under the same conditions; iv) identifying the glatiramer acetate related drug substance or drug product as causing a suboptimal activity if the level of expression of one or more genes selected from the group consisting of Gene Group 4 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate related drug substance or drug product under the same conditions; v) identifying the glatiramer acetate related drug substance or drug product as causing a suboptimal activity if the level of expression of one or more genes selected from the group consisting of Gene Group 5 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance or drug product under the same conditions; vi) identifying the glatiramer acetate related drug substance or drug product as causing a suboptimal activity if the level of expression of one or more genes selected from the group consisting of Gene Group 6, is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate related drug substance or drug product under the same conditions; vii) identifying the glatiramer acetate related drug substance or drug product as causing a suboptimal activity if the level of expression of one or more genes selected from the group consisting of Gene Group 7, is downregulated or substantially identical to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug substance or drug product under the same conditions; viii) identifying the glatiramer acetate related drug substance or drug product as causing a suboptimal activity if the level of expression of one or more genes selected from the group consisting of Gene Group 8, is upregulated or substantially identical to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug substance or drug product under the same conditions; ix) identifying the glatiramer acetate related drug substance or drug product as causing a suboptimal activity if the level of expression of one or more genes selected from the group consisting of Gene Group 9 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance or drug product under the same conditions; x) identifying the glatiramer acetate related drug substance or drug product as causing a suboptimal activity if the level of expression of one or more genes selected from the group consisting of Gene Group 10 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance or drug product under the same conditions; xi) identifying the glatiramer acetate related drug substance or drug product as causing a suboptimal activity if the level of expression of one or more genes selected from the group consisting of Gene Group 11 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xii) identifying the glatiramer acetate related drug substance or drug product as causing a suboptimal activity if the level of expression of one or more genes selected from the group consisting of Gene Group 12 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xiii) identifying the glatiramer acetate related drug substance or drug product as causing a suboptimal activity if the level of expression of one or more genes selected from the group consisting of Gene Group 13 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xiv) identifying the glatiramer acetate related drug substance or drug product as causing a suboptimal activity if the level of expression of one or more genes selected from the group consisting of Gene Group 14 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xv) identifying the glatiramer acetate related drug substance or drug product as causing a suboptimal activity if the level of expression of one or more genes selected from the group consisting of Gene Group 15 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xvi) identifying the glatiramer acetate related drug substance or drug product as causing a suboptimal activity if the level of expression of one or more genes selected from the group consisting of Gene Group 16 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xvii) identifying the glatiramer acetate related drug substance or drug product as causing a suboptimal activity if the level of expression of one or more genes selected from the group consisting of Gene Group 17 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xviii) identifying the glatiramer acetate related drug substance or drug product as causing a suboptimal activity if the level of expression of one or more genes selected from the group consisting of Gene Group 18 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xix) identifying the glatiramer acetate related drug substance or drug product as causing a suboptimal activity if the level of expression of one or more genes selected from the group consisting of Gene Group 19 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xx) identifying the glatiramer acetate related drug substance or drug product as causing a suboptimal activity if the level of expression of one or more genes selected from the group consisting of Gene Group 20 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxi) identifying the glatiramer acetate related drug substance or drug product as causing a suboptimal activity if the level of expression of one or more genes selected from the group consisting of Gene Group 21 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxii) identifying the glatiramer acetate related drug substance or drug product as causing a suboptimal activity if the level of expression of one or more genes selected from the group consisting of Gene Group 22 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxiii) identifying the glatiramer acetate related drug substance or drug product as causing a suboptimal activity if the level of expression of one or more genes selected from the group consisting of Gene Group 23 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxiv) identifying the glatiramer acetate related drug substance or drug product as causing a suboptimal activity if the level of expression of one or more genes selected from the group consisting of Gene Group 24 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxv) identifying the glatiramer acetate related drug substance or drug product as causing a suboptimal activity if the level of expression of one or more genes selected from the group consisting of Gene Group 25 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxvi) identifying the glatiramer acetate related drug substance or drug product as causing a suboptimal activity if the level of expression of one or more genes selected from the group consisting of Gene Group 26 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; xxix) identifying the glatiramer acetate related drug substance or drug product as causing a suboptimal activity if the level of expression of one or more genes selected from the group consisting of Gene Group 29 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions; or xxx) identifying the glatiramer acetate related drug substance or drug product as causing a suboptimal activity if the level of expression of one or more genes selected from the group consisting of Gene Group 30 is not substantially identical to the level of expression by the same type of cells in the presence of the glatiramer acetate drug substance under the same conditions.   
 
         [0243]    The Additional Embodiments described above can be readily applied and practiced with features of Embodiments of the Invention described in the section preceeding the Additional Embodiments. 
         [0244]    For example, in a process for producing a drug product comprising a glatiramer acetate related drug substance, where the batch of the glatiramer acetate related drug substance is included in the drug product if the level of expression of one or more genes selected from one or more Gene Groups is substantially upregulated relative to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug substance under the same conditions, then conversely the batch of the glatiramer acetate related drug substance is discarded if the level of expression of one or more genes selected from one or more Gene Groups is not substantially upregulated relative to the level of expression by the same type of cells in the absence of the glatiramer acetate related drug substance under the same conditions as unacceptable for inclusion in the drug product. 
       DEFINITIONS 
       [0245]    As used herein, a “naïve human” is a human that has not been treated with any multiple sclerosis drug. 
         [0246]    As used herein, a “glatiramoid naïve human” is a human that has not been treated with any glatiramoid drug. A glatiramoid naïve human could have been treated with another multiple sclerosis drug. 
         [0247]    As used herein, “in the blood of” is represented by peripheral blood mononuclear cells (PBMCs), lymphocytes, monocytes, macrophages, basophils, dendritic cells or other cells derived from a mammal&#39;s blood. 
         [0248]    As used herein, a “reference standard” is a sample or value which serves as a point of comparison for another sample or value which differs from the reference standard with respect to one or more variables. With specific regard to a human, a “reference standard” is a value or range of values that characterizes a defined population in a defined state of health. For example, a reference standard can characterize a healthy human or a human afflicted with multiple sclerosis, and when the human is afflicted with multiple sclerosis the human can be naïve or having received glatiramer acetate drug substance. 
         [0249]    As used herein, the term “glatiramer acetate related drug substance” (GARDS) is intended to include include polypeptides with a predetermined sequence as well as mixtures of polypeptides assembled from the four amino acids glutamic acid (E), alanine (A), lysine (K), and tyrosine (Y); from any three of the amino acids Y, E, A and K, i.e. YAK, YEK, YEA or EAK; or from three of the amino acids Y, E, A and K and a fourth amino acid. Examples of glatiramer acetate related polypeptides are disclosed in U.S. Pat. Nos. 6,514,938 A1, 7,299,172 B2, 7,560,100 and 7,655,221 B2 and U.S. Patent Application Publication No. US 2009-0191173 A1, the disclosures of which are hereby incorporated by reference in their entireties. Glatiramer acetate related substances include glatiramoids. 
         [0250]    As used herein, a “glatiramer acetate related drug product” (GARDP) contains a glatiramer acetate related drug substance. 
         [0251]    As used herein, a “glatiramer acetate related drug substance or drug product” is a glatiramer acetate related drug substance or a glatiramer acetate related drug product. 
         [0252]    As used herein a “glatiramoid” is a complex mixture of synthetic proteins and polypeptides of varying sizes assembled from four naturally occurring amino acids: L-glutamic acid, L-alanine, L-lysine, and L-tyrosine, in a defined molar ratio. Examples of glatiramoids include glatiramer acetate drug substance (e.g. Copaxone®) as well as glatiramoids other than Copaxone®, e.g. GA-Natco. 
         [0253]    As used herein, a “glatiramer acetate drug substance” (GADS) is glatiramer acetate produced by Teva Pharmaceutical Industries, Ltd. and is the active ingredient in a glatiramer acetate drug product. 
         [0254]    As used herein, a “glatiramer acetate drug product” (GADP) contains a glatiramer acetate drug substance produced by Teva Pharmaceutical Industries, Ltd. which consists of the acetate salts of synthetic polypeptides, containing four naturally occurring amino acids: L-glutamic acid, L-alanine, L-tyrosine, and L-lysine with an average molar fraction of 0.141, 0.427, 0.095, and 0.338, respectively, and has an average molecular weight of 5,000-9,000 daltons. (8) Copaxone® is a glatiramer acetate drug product. 
         [0255]    As used herein, a “glatiramer acetate drug substance or drug product” is a glatiramer acetate drug substance or a glatiramer acetate drug product. 
         [0256]    As used herein a “glatiramer acetate reference standard” is or contains the drug substance found in a glatiramer acetate drug product. 
         [0257]    As used herein “suboptimal activity” refers to a negative response or to a response which is less than the response to glatiramer acetate drug substance or glatiramer acetate drug product produced by Teva Pharmaceutical Industries, Ltd. 
         [0258]    As used herein, “release” of a drug product refers to making the product available to consumers. 
         [0259]    As used herein, “about” with regard to a stated number encompasses a range of +10 percent to −10 percent of the stated value. By way of example, about 100 mg therefore includes the range 90-110 mg and therefore also includes 90, 91, 92, 93, 94, 95 96, 97, 98, 99, 100, 101, 102, 103, 104, 105, 106, 107, 108, 109 and 110 mg. Accordingly, about 100 mg includes, in an embodiment, 100 mg. 
         [0260]    As used herein, “hematological cell” comprises neutrophils, erythrocytes, basophils, monocytes, eosinophils, platelets, lymphocytes, and splenocytes. 
         [0261]    As used herein, an “array of testing” for a glatiramer acetate related drug substance or drug product includes, but is not limited to, any analytical method test such as in vitro tests or molecular weight tests, biological assays such as the ex vivo tests and clinical efficacy tests which characterize the GARDS or GARDP, or clinical trials. Examples of testing for a glatiramer acetate related drug substance or drug product are disclosed in U.S. Patent Application Publication Nos. US 2012-0309671 and US 2011-0230413, and in PCT International Application Publication Nos. WO 2000/018794, WO 2012/051106, WO 2013/055683, WO 2014/058976, the disclosures of which are hereby incorporated by reference in their entireties. 
         [0262]    It is understood that where a parameter range is provided, all integers within that range, tenths thereof, and hundredths thereof, are also provided by the invention. For example, “0.2-5 mg” is a disclosure of 0.2 mg, 0.21 mg, 0.22 mg, 0.23 mg etc. up to 0.3 mg, 0.31 mg, 0.32 mg, 0.33 mg etc. up to 0.4 mg, 0.5 mg, 0.6 mg etc. up to 5.0 mg. 
         [0263]    All combinations of the various elements described herein are within the scope of the invention. 
         [0264]    It is understood that where “at least one” or “one or more” is recited along with a list, then 1, 2, 3, 4 . . . or all members of that list are disclosed in every combination. For example, in a group of 43 genes, “at least one” and “one or more” is a disclosure of one gene, two genes, three genes, etc., in any combination, up to the forty three genes. 
         [0265]    As used herein, “characterization” or “characterizing” is understood to include obtaining information which was produced in the same location or country, or a different location or country from where any remaining steps of the method are performed. 
         [0266]    As used herein, processes of producing a glatiramer acetate related drug substance or drug product are known in the art. Examples of such manufacturing processes are disclosed in U.S. Pat. No. 5,800,808, and in PCT International Application Publication Nos. WO 2005/032553, WO 2005/032395, WO 1999/22402, the disclosures of which are hereby incorporated by reference in their entireties. 
         [0267]    Each embodiment disclosed herein is contemplated as being applicable to each of the other disclosed embodiments. Thus, all combinations of the various elements described herein are within the scope of the invention. 
         [0268]    This invention will be better understood by reference to the Experimental Details which follow, but those skilled in the art will readily appreciate that the specific experiments detailed are only illustrative of the invention as described more fully in the claims which follow thereafter. 
       EXPERIMENTAL DETAILS 
     Methods 
       [0269]    The null hypothesis in traditional gene-expression studies, including Teva&#39;s studies with the glatiramoids, is that there are no significant gene expression differences induced between the treatments. As such, the expectation is that regardless of the biological system used for testing, genes would show no statistically significant, nor biologically meaningful differences among the various treatments. Only in cases where the treatments induce significant observable effects, genes differentially expressed between treatments will pass the stringent statistical tests, and false discovery rate (FDR) correction for multiple hypotheses (Benjamini and Hochberg, 1995). These stringent requirements were imposed a priori across all tests to ensure robustness of results and minimizing of spurious findings. Such statistically significant differences, if biologically meaningful (i.e., related to the disease biology or any of the drug&#39;s known or putative targets and downstream pathways), warrant further studies, as two drugs that have identical activities in biological systems should not induce statistically observable and biologically enriched differences when compared against each other. 
         [0270]    These studies were not designed to establish a particular set of genes in a specific model system as a panel to evaluate sameness between differently manufactured glatiramoids. Instead, these were designed to assess the degree of similarity in the impact of two glatiramoids on relevant biological pathways. The application of robust methodology (high number of replicates, conditions and time-points, where relevant) was aimed to describe pathways changed by different treatments out of the entire milieu of genomic patterns. The results obtained across the tested experimental models revealed statistically significant differences between drugs, which were intended to be similar and to perform the same function, despite stringent statistical threshold requirements. This was noteworthy particularly in genes highly relevant to disease processes and drug response mechanisms. In addition, the differences observed revealed a complex interplay between immunological pathways, such that some differences were common to multiple systems, while many others were dependent on the specific model system (for example, some key genes modulated in T cells were not the same as in monocytes). This is not surprising for a process that involves multifaceted interactions between many immune system components, and is also exemplified in experimental studies of Copaxone®&#39;s mechanism of action. Thus, no single model system, characterization method, or set of genes tested was sufficient to comprehensively capture the differences between the drugs. These observations indicate a need for in-depth investigation of comparative gene expression profiles in several relevant pre-clinical systems as key indicators of similarity and/or sameness between generic candidates and the original drug within the context of Non-Biological Complex Drugs (NBCD). Ideally, the concordance between high-resolution physicochemical measures (e.g. ion motility mass spectrometry, IMMS), gene expression profiling and clinical trials would allow a more definitive assessment of equivalence in terms of patient benefit and safety. 
       Mice 
       [0271]    All experimental procedures conformed to accepted ethical standards for use of animals in research and were in accordance with Committee for the Care and Use of Experimental Animals guidelines and approved by the Teva Institutional Animal Care and Use Committee. 
       Preparation of Mouse Spleen Cell Cultures 
       [0272]    All experimental procedures conformed to accepted ethical standards for use of animals in research and were in accordance with Committee for the Care and Use of Experimental Animals guidelines and approved by the Teva Institutional Animal Care and Use Committee. 
       Mouse Splenocytes: Gene Expression Analysis 
       [0273]    In the first of the genomic studies, 8- to 12-week old female mice (N=8) of the (Balb/c x SJL) F1 variety (Harlan, Israel) were injected subcutaneously with glatiramer acetate (GA) in order to induce specific GA-reactive T cells as would be present in a Copaxone® treated patient. 
         [0274]    After 3 days, the mice were sacrificed and cells from their spleens (splenocytes) were isolated because such cells are representative of, and commonly utilized as a gold standard to study the immune system. The aqueous activator samples, mannitol (the non-active excipient in Copaxone® and all other marketed proposed generics) and medium were used as negative controls. 
         [0275]    Given the robustness of the model established in our first mouse splenocyte study, we sought to expand the scope of the investigation using the exact same study design, but with an expanded set of treatments ( FIG. 1 ). In addition to comparing Copaxone® to a purported foreign generic version, we also sought to compare purported generics from various manufacturers to each other. Using the mouse splenocyte procedure described herein, we generated expression data in response to activation with proposed generic glatiramer acetate samples from Escadra (Argentina), Probioglat (Mexico; Probiomed), and Hangzhou (China: API). A total of 21 samples of Copaxone® from 21 different batches were used, along with 10 samples from 2 lots of Escadra, 12 samples from 4 batches of Natco, 4 samples from 1 batch of Probioglat, 5 samples of Hangzhou from 2 batches, 12 samples of GA-RS from 1 batch, and 8 samples of medium. 
       Mouse Splenocytes: RNA Isolation and Microarray Expression Profiling 
       [0276]    Extraction of total RNA from activated splenocytes was extracted using PerfectPure RNA Cultures CEKK kit 50 (5Prime GmbH, Hamburg, Germany) and following the manufacturer&#39;s instructions. RNA quality was assessed using the absorbance ratio at 260/280 nm and gel electrophoresis (Experion, Bio-Rad, Hercules, Calif., USA). Total RNA extracted from samples was hybridized to Illumina Mouse WG-6V2 microarray chips containing more than 45,200 transcripts. 
         [0277]    Samples were randomized on the chips to avoid batch effects. Illumina&#39;s BeadStudio software was utilized for image processing, quantification of signal intensity per bead, and background signal correction. Multiple probes were analyzed for a given gene were averaged and batch correction was conducted using Partek. Further analysis was conducted individually within the context of known pathways, and batch correction was conducted using ComBat, as implemented in the SVA R package sva: Surrogate Variable Analysis. Available: www.bioconductor.org/packages/release/bioc/html/sva.html). Briefly, ComBat is an empirical Bayesian approach utilizing location and scale metrics across several genes to adjust for batch effects in datasets, even datasets containing small sample sizes. Treatment labels were added as covariates to the batch correction in order to preserve relevant treatment effects. Principal Component Analysis (a multivariate approach) showed that the main effect in the first principal component remained due to treatment effects after batch correction. 
         [0000]    Mouse Splenocytes: Gene Expression Analysis—Polimunol versus Copaxone® Gene Expression Studies 
       Mice 
       [0278]    All experimental procedures conformed to accepted ethical standards for use of animals in research and were in accordance with Committee for the Care and Use of Experimental Animals guidelines and approved by the Teva Institutional Animal Care and Use Committee. For these experiments, 8- to 12-week-old female (Balb/c X SJL) F1 mice (Janvier, France) were purchased. Mice were kept at 21±3° C.; the relative humidity was 30-70%, the light/dark cycle was 12/12 h. Animals were maintained on a standard rodent pellet diet and sterile filtered tap water available ad libitum. 
         [0279]    Preparation of Mouse Spleen Cell Cultures 
         [0280]    To stimulate induction of GA-reactive T cells, twelve mice were injected with 100 μL of a 2.5 mg/mL solution of GA reference standard (GA-RS) in phosphate-buffered saline (250 μg GARS per mouse). GA-RS (Teva) is a selected GA drug substance batch defined as the standard batch and used as a reference in quality control release tests of all Copaxone® batches. Another group of twelve mice were injected with 100 μL of a 2.5 mg/mL solution of Polimunol in phosphate-buffered saline (250 μg Polimunol per mouse). Polimunol is a proposed generic manufactured a company other than Teva. Mice were housed for 3 days after immunization; mice were then sacrificed and their spleens were aseptically removed and placed on ice in RPMI 1640. A single cell suspension was prepared. After red blood cells lysis, splenocytes from the same immunization group were pulled and resuspended to a final concentration of 10×106 cells/mL in defined cell culture media (DCCM1) (Biological Industries, Beit Haemek, Israel) (96.7% v/v) enriched with L-glutamine 2 mM (1% v/v), MEM Non-Essential Amino Acids 2 mM (1% v/v), sodium pyruvate 1 mM (1% v/v), antibiotic/antimycotic solution (0.2% v/v) and 2-mercaptoethanol 50 mM (0.1% v/v). 
       In Vitro Cell Activation 
       [0281]    Splenocytes were treated with activator samples diluted in medium (125 μL per well of 80 μg/mL solutions, final concentration in the well: 40 μg/mL) of: i) 3 different batches of GA drug product manufactured by Teva ii) one batch of proposed generic (Polimunol). Polimunol is a product marketed as generic GA and manufactured by a company other than Teva (i.e. Synthon). The activator samples, mannitol (the nonactive excipient in Copaxone®), and medium were added to 96-well tissue culture plates (three wells per sample). Splenocytes (125 μL 10×10 6  SPL cell/mL suspension) were added to the activator solutions. Each activator sample was loaded in two different plates. One for the cells from mice immunized with GA and one for cells from mice immunized with proposed generic. Plates were incubated for 24 h at 37° C. Cells were collected from the wells and were centrifuged at 300 g for 5 minutes. Supernatants were aspirated and cell pellets were resuspended in RLT buffer (from RNeasy mini kit of Qiagen, Cat #74106) for cell lysis. The cell lysates were centrifuged and supernatants were collected and frozen at −70° C. Samples were sent for further processing. 
         [0282]    Analysis Methods 
         [0283]    For additional detail on experimental methods used in mouse studies, please refer to publications [Bakshi et al; Towfic et al]. Note that in this study, mice were immunized with either Copaxone® or Polimunol, and subsequently splenocytes were isolated and treated ex vivo with Copaxone® or Polimunol. RNA was extracted and expression profiled across the entire genome using the Affymetrix Mouse Genome 430 2 chip. Three lots of Copaxone®, and one lot of Polimunol were comparatively tested in six replicates each. 
       Outlier Identification and Normalization 
       [0284]    Outlier samples were identified using the R package ArrayQCMetrics and excluded from further data processing steps. A sample was considered an outlier if it failed more than half of the included tests either before or after RMA normalization. Data were RMA normalized using the Affy R package. 
       Batch Correction 
       [0285]    Correction for batch variation was performed using ComBat as described above (THP-1 methods). Date of microarray experiment was used as batch, and the combination of treatment and immunization was used as covariate. Principal Component Analysis (a multivariate approach) showed that the main effect in the first principal component remained due to treatment effects after batch correction. 
       Differential Expression Analysis 
       [0286]    Differentially expressed probesets were identified across conditions using linear models for microarray data (LIMMA; Smyth, G. K. (2004)), a standard R Bioconductor package. Linear models and empirical Bayes methods for assessing differential expression in microarray experiments. Statistical Applications in Genetics and Molecular Biology 3, No. 1, Article 3). To compare GA and purported generic, comparisons were corrected to compare each treatment relative to mannitol control (e.g., [GA vs mannitol] was compared via LIMMA to [Polimunol vs mannitol]). Probesets were filtered by MAS5 calls of presence on the chip (to be considered present, a probeset was required to have on average a call of present or marginal across samples). Probesets were mapped to genes using the annotation available for the Mouse 430 2 chip from Affymetrix. Unless otherwise noted, FDR adjusted p values reported for genes represent the lowest FDR adjusted p value for present probesets for that gene. 
       Pathway Enrichment Analysis 
       [0287]    Upregulated and downregulated probesets were analyzed separately for pathway enrichment, using DAVID (Huang et al, Nucleic Acids Res 2009). Pathway enrichment results were visualized using volcano plots, plotting either −log adjusted p values or untransformed adjusted p values versus enrichment scores for the pathways. For comparisons between branded GA and Polimunol, upregulated or downregulated probesets with FDR-adjusted p values&lt;0.05 and fold changes (FC) with absolute value greater than 1.2 were used for pathway enrichment. For comparisons between branded GA and mannitol, upregulated or downregulated probesets with FDR-adjusted p values&lt;0.05 and FC with absolute value greater than 2 were used for pathway enrichment. DAVID runs were conducted in December 2014 and January 2015. 
       Human Monocyte Cell Line: Gene Expression Analysis 
       [0288]    THP-1 human monocytes (TIB-202) were purchased from ATCC®. Cells were maintained in recommended RPMI-1640 media containing FCS, L-Glutamine, Sodium Pyruvate, D-Glucose, HEPES, and 2-mercaptoethanol at 37° C. and 5% CO2. Prior to treatment cells were passed and plated in a 6-well plate at a concentration of 1.0×10 6  cells/mL. Cells were allowed to recover for four hours after passage (prior to treatment). Using a predetermined non toxic concentration the cells were spiked with 50 μg/mL of either Copaxone®, GA/RS, Escadra, Probioglat, and Natco, and 100 μg/mL mannitol was spiked as a negative control (vehicle). Each sample was analyzed in six replicates. Cells were treated for 6, 12, and 24 hours. Following treatment time cells were lysed using a Qiagen® based lysis kit. Prior to RNA isolation samples were randomized in order to avoid batch effect. Total RNA was isolated using Qiagen® RNeasy kit. RNA quality was assessed by determining the absorbance ratio 260/280 nm as well as electrophoresis bioanalyzer with 260/280 ratio of 1.9-2.1 and RIN of above 9 were deemed acceptable. Gene expression was measured using Affymetrix® U133 plus 2.0 format. Sample processing was executed according to established manufacturer protocols. The scheme in ( FIG. 2 ) illustrates the general experimental outline. 
       Human Monocyte Cell Line: RNA Isolation and Microarray Expression Profiling 
       [0289]    RNA from THP-1 cells was extracted and expression profiled across the entire genome using the Affymetrix Human Genome U133 Plus 2.0 chip, interrogating a total of over 47,000 transcripts. Four batches of Copaxone® and one batch of Probioglat were comparatively tested in six biological replicates each. Key identified genes were independently evaluated for level of gene expression by quantitative Real-Time PCR of samples collected in the same experiments. 
       Methods for Studies Using MS Patient Data 
       [0290]    Patient studies utilized a subset of MS patients treated with Copaxone® from FORTE clinical trial with time-series PBMC expression profiling. Timepoints of 0, 1, 2, 3 months were used. The study included 9 patients for a total of 36 samples. 
       Repeated-Measures ANOVA 
       [0291]    ANOVA was run taking into account multiple timepoints from each patient. Variability within patients across timepoints was taken into account in the p value calculation. 
         [0000]    qRT-PCR Analysis 
         [0292]    Key genes identified by differential expression analysis were assayed using qRT-PCR. RNA was utilized from each of 6 biological samples for each treatment (Copaxone® and Probioglat) and 15 technical replicates were performed for each sample (a total of 90 observations per transcript per treatment). Since three Copaxone® batches and one Probioglat batch were available, a total of 360 observations from each transcript were evaluated. To evaluate the data, the 2 −ΔΔct  approximation was utilized with GAPDH as reference transcript and vehicle control (mannitol) as calibrator. A one-sided t-test with unequal variance was used to compare the RNA expression from the two treatments. 
         [0000]    Human Monocyte Cell Line: Gene Expression Analysis—Polimunol versus Copaxone® Gene Expression Studies 
       Experimental Design 
       [0293]    Cells from a human monocyte cell line (THP-1) were stimulated with either branded glatiramer acetate—Copaxone®, or the purported generic Polimunol, or vehicle control (mannitol) for 6 hours. RNA was extracted and expression profiled in a blinded fashion across the entire genome, using the Affymetrix Human Genome U133 Plus 2.0 chip, interrogating a total of over 47,000 transcripts. Three lots of Copaxone® (148, 164, 166) and one lot of Polimunol (XBN) were comparatively tested in six replicates each. This entire experiment was performed independently twice, using an identical study design, reagents and compounds by the same technicians on two separate days; resulting in twelve replicates total per condition. 
       A Priori Power Analysis 
       [0294]    Using the R statistical package ssize.fdr, power calculations were performed to determine the number of samples needed to detect differentially expressed genes with a fold-change between treatments of as low as 1.3 with 80% power. Based on the results of these power calculations, the experiment was designed to include six replicates of each condition. The order in which the samples were processed was randomized with respect to treatment and stimulation time in order to avoid creating confounding batch effects. 
       Outlier Identification and Normalization 
       [0295]    Outlier samples were identified using the R package ArrayQCMetrics and excluded from further data processing steps. A sample was considered an outlier if it failed more than half of the included tests either before or after RMA normalization. Data were RMA normalized using the Affy R package. 
       Batch Correction 
       [0296]    Correction for batch variation was performed using ComBat (Johnson et al, Biostat, 2007), as implemented in the SVA R package (Leek J T, Johnson W E, Parker H S, Jaffe A E, Storey J D (2013) sva: Surrogate Variable Analysis. Available: www.bioconductor.org/packages/release/bioc/html/sva.html). Briefly, ComBat is an empirical Bayesian approach utilizing location and scale metrics across several genes to adjust for batch effects in datasets, even datasets containing small sample sizes. Date of experiment was utilized as batch. Treatment labels were added as covariates to the batch correction in order to preserve relevant treatment effects. Principal Component Analysis (a multivariate approach) showed that the main effect in the first principal component remained due to treatment effects after batch correction. 
         [0297]    Treatment labels were added as covariates to the batch correction to preserve relevant treatment effects. Principal Component Analysis showed the main effect in PC1 remained due to treatment effects after batch correction ( FIG. 43 ). 
       Differential Expression Analysis 
       [0298]    Differentially expressed probesets were identified across conditions using linear models for microarray data (LIMMA; Smyth, G. K. (2004)), a standard R Bioconductor package. Linear models and empirical Bayes methods for assessing differential expression in microarray experiments. Statistical Applications in Genetics and Molecular Biology 3, No. 1, Article 3). To compare Copaxone® and a purported generic, comparisons were corrected to compare each treatment relative to mannitol control (e.g., [GA vs mannitol] was compared via LIMMA to [purported generic vs mannitol]). For use in pathway analyses, probesets were filtered by MAS5 calls of presence on the chip for the relevant samples in the comparison (e.g., to be considered present, a probeset was required to have on average a call of present or marginal across samples). An additional QC step was performed to remove probesets determined to be highly variable between multiple THP-1 datasets, as follows: a probeset was deemed highly variable if across three THP-1 studies to date, that probeset was observed to be upregulated, downregulated, and not modulated by Copaxone across the three studies. This criterion resulted in filtering out 216 probesets. Probesets were mapped to genes using the annotation available for the U133 Plus 2.0 chip from Affymetrix. FDR adjusted p values reported for genes represent the lowest FDR adjusted p value for present probesets for that gene. 
       Pathway Enrichment Analysis 
       [0299]    Upregulated and downregulated probesets were analyzed separately for pathway enrichment, using DAVID (Huang et al, Nucleic Acids Res 2009). Pathway enrichment results were visualized using volcano plots, plotting −log p values versus enrichment scores. For comparisons between Copaxone and Polimunol, upregulated or downregulated probesets with FDR-adjusted p values&lt;0.05 and fold changes (FC) with absolute value greater than 1.1 were used for pathway enrichment. For comparisons between Copaxone® and mannitol, upregulated or downregulated probesets with FDR=adjusted p values&lt;0.05 and FC with absolute value greater than 1.3 were used for pathway enrichment. DAVID runs were conducted December 5 and 10, 2014. 
       Protein Concentrations 
       [0300]    THP-1 cells were activated with GA or Probioglat as described above. The supernatant (1.0 mL of cell culture media) was collected at the 24 hour timepoint (to account for the time duration required for translation relative to the 6 hour mRNA data reported herein). 
         [0301]    A Luminex assay was utilized to measure the concentrations of a panel of 45 chemokines and cytokines (in pg/ml) using Bio-Plex Human Chemokine (Bio Rad kit) and Luminex Performance Assay (R&amp;D kit). Three of the genes that were found to significantly differ between GA and Probioglat by qRT-PCR (CXCL10, MMP9, and CCL5/RANTES) had corresponding proteins present in the Luminex panel. In addition, two other genes that were found to differ significantly between GA and Probioglat using the genome-wide microarray mRNA data were also present in the Luminex panel (CCL2, IL10). 
         [0302]    To calculate the fold change between the protein expression levels with Probioglat and with GA, the values for the four GA batches were averaged together and compared to the value for Probioglat (Probioglat expression level/average GA expression level). 
       Primary Human Monocyte Study 
       [0303]    50 mL of blood was obtained from a healthy donor, and CD14+ cells were separated from whole blood using magnetic beads (Miltenyi Biotech). Purity was determined by FACS analysis using the following antibodies: CD14, CD15, CD16, CD45 (BD Biosciences). Into each plate of the 6 well plate 0.5 mL containing 1.0×10 6  cells was added. In addition 0.5 mL of either Copaxone, Probioglat (100 μg/mL) or mannitol (200 μg/mL) was added, total volume in each well was 1 mL. Final concentration of Copaxone and Probioglat was 50 μg/mL and mannitol final concentration was 100 μg/mL. Cells were incubated for 6 hours at 37° C. at 5% CO 2  followed by centrifugation to pellet the cells. The cell pellets were then processed using a Qiagen RNeasy RNA purification protocol. 
         [0304]    Expression levels of nine genes were measured using RT-PCR with GAPDH as reference transcript. Analyses reported compared Probioglat samples to GA samples as calibrator. Similar results were obtained when using mannitol as reference (i.e., the same set of genes were significantly upregulated in Probioglat relative to Copaxone). Differences in expression levels were evaluated for significance using one-sided t-tests with unequal variance. 
       Example 1 
     Analysis of Time-sensitive Modulation of Genes by Copaxone® Treatment in TRP-1 Monocyte Cell Line 
       [0305]    Three time points were tested to identify the time point reflecting the greatest impact of treatment in each model system. Examining the number of genes modulated by Copaxone® relative to the mannitol control, the 6 hour time point demonstrated the largest number of genes significantly modulated by Copaxone® (6,890 with an FDR-adjusted p&lt;0.05), over 2-fold more than at 12 hours (3,118 with FDR-adjusted p&lt;0.05) and nearly 4-fold more than at 24 hours (1,791 with FDR-adjusted p&lt;0.05) (Table 1). Subsequent analyses focused on the 6 hour time point, as the time point reflected the greatest impact of treatment in this model system. 
         [0000]    
       
         
               
             
               
               
               
               
             
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
             
           
               
                 TABLE 1 
               
             
             
               
                   
               
               
                 Numbers of genes significantly modulated by GA treatment 
               
               
                 in THP-1 monocyte cell line at each timepoint 
               
             
          
           
               
                   
                 6 hr 
                 12 hr 
                 24 hr 
               
             
          
           
               
                   
                 Up- 
                 Down- 
                 Up- 
                 Down- 
                 Up- 
                 Down- 
               
               
                   
                 regu- 
                 regu- 
                 regu- 
                 regu- 
                 regu- 
                 regu- 
               
               
                   
                 lated 
                 lated 
                 lated 
                 lated 
                 lated 
                 lated 
               
               
                   
               
             
          
           
               
                 nominal 
                 3511 
                 4909 
                 2377 
                 3430 
                 1410 
                 3724 
               
               
                 p &lt; 0.05 
                   
                   
                   
                   
                   
                   
               
               
                 FDR 
                 2824 
                 4066 
                 1308 
                 1810 
                 606 
                 1185 
               
               
                 p &lt; 0.05 
                   
                   
                   
                   
                   
                   
               
               
                 FDR 
                 257 
                 119 
                 68 
                 10 
                 15 
                 0 
               
               
                 p &lt; 1e−5, 
                   
                   
                   
                   
                   
                   
               
               
                 |FC| &gt;= 1.5 
                   
                   
                   
                   
                   
                   
               
               
                 FDR 
                 557 
                 508 
                 210 
                 50 
                 57 
                 6 
               
               
                 p &lt; 1e−5, 
                   
                   
                   
                   
                   
                   
               
               
                 |FC| &gt;= 1.3 
               
               
                   
               
               
                 * FC—Fold Change; FDR—False Discovery Rate correction 
               
             
          
         
       
     
       GA Mechanism of Action 
       [0306]    To gain insight into GA&#39;s MOA, the effect of GA treatment on THP-1 human monocytes was examined, since as discussed above, antigen-presenting cells in general, including monocytes in particular, have been shown to be involved in GA treatment effects (Weber et al., Nat. Med. 2007; Kim et al, J. Immunol. Batim. Md. 2004; Burger et al., Proc. Natl. Acad. Sci. 2009; Smyth, Stat. Appl. Genet. Mol. Biol. 2004; Comi et al., Neurol. Barc. Spain 2002). In particular, the THP-1 cell line has been used to examine GA effects (Rizvi et al., Int. J. Nanomedicine, 2006). In addition, genes associated with monocytes in particular have previously been shown to be differentially expressed following treatment with a purported generic marketed by Natco in India, as compared with Copaxone (Huang et al., Nucleic Acids Res. 2009). 
         [0307]    mRNA expression levels were compared between GA and control (mannitol) tested with 6 sample replicates for each of 4 batches of GA and for mannitol, using LIMMA (Sim et al., Nat. Biotechnol. 2011) (Methods). Many genes were modulated significantly (FDR-adjusted p-value&lt;0.05) at each timepoint by treatment with branded GA (Table 1; Table 2 lists top modulated probesets). For example, at 6 hours of GA treatment, 2824 genes were significantly increased in expression (here termed upregulated) by FDR-adjusted p-value&lt;0.05 (3511 genes by nominal p-value&lt;0.05) and 4066 genes were significantly decreased in expression (here termed downregulated) by FDR-adjusted p-value&lt;0.05 (4909 genes by nominal p-value&lt;0.05). Fewer genes were significantly modulated as treatment time increased, with approximately half as many modulated at 12 hours, and approximately one-quarter at 24 hours (Table 1). We chose 6h for initial downstream analysis since this timepoint reflects the greatest impact of treatment. Levels of GA persisted in the cell culture medium in the range of 44-52 μg/mL over 24 hours ( FIG. 3 ), indicates that this observation is unlikely to reflect a decrease in concentration of drug. Rather, this decrease in number of genes affected from early to later timepoints represents an attribute of the response of the cells to the drug. 
         [0308]    GA impacts expression most pronouncedly at 6h (Table 2). The use of this early timepoint may also be biologically relevant given that GA is thought to be rapidly degraded at the injection site, eventually without measurable blood levels (Vieira et al., J. Immunol. Baltim. Md 1950, 2003; Thamilarasan et al., J. Neuroinflammation 2013; Comi et al, Neurol 2002, Rizvi et al, Int J Nanomed 2006). 
         [0309]    The differentially expressed genes included several anti-inflammatory genes. For instance, IL10, the gene encoding the anti-inflammatory cytokine IL-10, was increased in expression (upregulated) at the 6 hour timepoint (FDR adjusted p value 3.1e-9; fold change (FC) 1.52;  FIG. 4 a   ). Expression of IL1RN, encoding IL-1ra, a protein that inhibits the activities of the pro-inflammatory cytokines IL-1a and IL-1b, was increased (upregulated) at all three timepoints.  FIG. 4 b - d    shows the 6h timepoint for all present probesets (FDR adjusted p values 6.7e-16, 1.7e-10, and 1.2e-9, and FC 1.43, 1.35, and 1.26, respectively). 
         [0310]    To determine whether the differentially-expressed genes related to one another in a coordinated fashion, top significantly up- and down-regulated genes were examined for pathway enrichment using DAVID as described in Methods ( FIG. 5 ; Table 5). The top genes significantly upregulated by Copaxone in the human THP-1 cell line at 6 hours of treatment were enriched significantly (by Benjamini corrected p value&lt;0.05) for 114 pathways (Table 5), including many immune-related pathways ( FIG. 5 ). For example, the regulation of immune system process (GO:0002682) and cytokine-cytokine receptor interaction (hsa04060) pathways were both significantly enriched among the top upregulated genes. The top upregulated genes identified as members of the cytokine-cytokine receptor interaction pathway (hsa04060) are shown in  FIG. 6 . In addition, 9 pathways were significantly enriched among genes downregulated by GA (Table 5). 
         [0000]    
       
         
               
             
               
               
               
               
               
               
             
               
             
               
               
               
               
               
               
             
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 2 
               
             
             
               
                   
               
               
                 Human monocyte study: probesets significantly modulated by 
               
               
                 Copaxone ® relative to mannitol at 6 hours, subject to 
               
               
                 fold-change and adjusted p value filters of 1.5 and 1e−5 
               
             
          
           
               
                 ID 
                 Gene 
                 raw.FC 
                 AveExpr 
                 P.Value 
                 adj.P.Val 
               
               
                   
               
             
          
           
               
                 Upregulated: 
               
             
          
           
               
                 201005_at 
                 CD9 
                 3.77232321 
                 10.8126963 
                 1.14E−34 
                 6.23E−30 
               
               
                 206835_at 
                 STATH 
                 7.52573433 
                 10.4825707 
                 1.00E−33 
                 2.74E−29 
               
               
                 1553982_a_at 
                 RAB7B 
                 2.26468475 
                 11.7452289 
                 1.26E−31 
                 2.30E−27 
               
               
                 242871_at 
                 PAQR5 
                 3.9374814 
                 9.90015385 
                 7.51E−31 
                 1.01E−26 
               
               
                 1555759_a_at 
                 CCL5 
                 2.21501539 
                 13.5769189 
                 9.21E−31 
                 1.01E−26 
               
               
                 228766_at 
                 — 
                 2.3291844 
                 10.5559717 
                 3.35E−30 
                 3.06E−26 
               
               
                 209555_s_at 
                 CD36 
                 2.44281389 
                 9.32514677 
                 7.64E−29 
                 5.66E−25 
               
               
                 203939_at 
                 NT5E 
                 5.3338766 
                 8.32269063 
                 8.29E−29 
                 5.66E−25 
               
               
                 208789_at 
                 PTRF 
                 2.82016222 
                 9.15275301 
                 1.88E−28 
                 1.14E−24 
               
               
                 230266_at 
                 RAB7B 
                 2.23824891 
                 11.7520076 
                 2.34E−28 
                 1.28E−24 
               
               
                 206488_s_at 
                 CD36 
                 2.15872949 
                 10.8868374 
                 3.67E−28 
                 1.83E−24 
               
               
                 208121_s_at 
                 PTPRO 
                 2.14699192 
                 9.81795145 
                 4.30E−28 
                 1.96E−24 
               
               
                 203037_s_at 
                 MTSS1 
                 3.1858517 
                 11.4020576 
                 7.89E−28 
                 3.32E−24 
               
               
                 1405_i_at 
                 CCL5 
                 2.29122708 
                 13.3028093 
                 2.79E−27 
                 1.06E−23 
               
               
                 204655_at 
                 CCL5 
                 2.25036905 
                 13.1626051 
                 2.90E−27 
                 1.06E−23 
               
               
                 206171_at 
                 ADORA3 
                 2.10036549 
                 10.0753041 
                 3.42E−27 
                 1.17E−23 
               
               
                 219386_s_at 
                 SLAMF8 
                 2.98872777 
                 10.0302719 
                 3.80E−27 
                 1.22E−23 
               
               
                 226218_at 
                 — 
                 3.50148157 
                 7.21345525 
                 1.83E−26 
                 5.55E−23 
               
               
                 218559_s_at 
                 MAFB 
                 2.64025573 
                 12.4234341 
                 3.40E−26 
                 9.78E−23 
               
               
                 223125_s_at 
                 C1ORF21 
                 2.21866076 
                 11.0023707 
                 4.15E−26 
                 1.13E−22 
               
               
                 203887_s_at 
                 THBD 
                 1.79337816 
                 12.8191102 
                 4.45E−26 
                 1.15E−22 
               
               
                 227265_at 
                 KIAA1505 
                 2.50321069 
                 9.85031558 
                 4.61E−26 
                 1.15E−22 
               
               
                 205495_s_at 
                 GNLY 
                 2.40116081 
                 7.73128126 
                 5.34E−26 
                 1.27E−22 
               
               
                 216250_s_at 
                 LPXN 
                 2.1444933 
                 11.2374219 
                 1.42E−25 
                 3.23E−22 
               
               
                 237252_at 
                 THBD 
                 2.06547107 
                 9.51011605 
                 2.22E−25 
                 4.86E−22 
               
               
                 235457_at 
                 MAML2 
                 2.62488399 
                 8.91497905 
                 5.79E−25 
                 1.22E−21 
               
               
                 225171_at 
                 ARHGAP18 
                 1.83225951 
                 10.7080346 
                 6.66E−25 
                 1.35E−21 
               
               
                 204684_at 
                 NPTX1 
                 2.87807656 
                 10.9346668 
                 1.40E−24 
                 2.74E−21 
               
               
                 230925_at 
                 APBB1IP 
                 1.94283823 
                 12.7655513 
                 2.02E−24 
                 3.81E−21 
               
               
                 201590_x_at 
                 ANXA2 
                 1.68959054 
                 13.1436175 
                 3.46E−24 
                 6.31E−21 
               
               
                 206157_at 
                 PTX3 
                 1.98670615 
                 11.2102165 
                 3.62E−24 
                 6.38E−21 
               
               
                 216080_s_at 
                 FADS3 
                 2.27239911 
                 9.71739825 
                 3.75E−24 
                 6.39E−21 
               
               
                 221463_at 
                 CCL24 
                 3.58807723 
                 8.40481021 
                 3.93E−24 
                 6.39E−21 
               
               
                 210427_x_at 
                 ANXA2 
                 1.67415609 
                 13.1118777 
                 3.98E−24 
                 6.39E−21 
               
               
                 213503_x_at 
                 ANXA2 
                 1.72399354 
                 13.1135447 
                 4.18E−24 
                 6.51E−21 
               
               
                 238681_at 
                 GDPD1 
                 2.92185146 
                 7.19901556 
                 4.29E−24 
                 6.51E−21 
               
               
                 202458_at 
                 PRSS23 
                 2.98100135 
                 7.79000143 
                 5.03E−24 
                 7.43E−21 
               
               
                 203761_at 
                 SLA 
                 1.78030673 
                 11.2608124 
                 6.52E−24 
                 9.38E−21 
               
               
                 1558397_at 
                 — 
                 2.20691751 
                 9.17869031 
                 8.35E−24 
                 1.17E−20 
               
               
                 214054_at 
                 DOK2 
                 1.67191836 
                 12.2431311 
                 8.80E−24 
                 1.20E−20 
               
               
                 228937_at 
                 C13ORF31 
                 2.42816683 
                 9.90878354 
                 9.66E−24 
                 1.29E−20 
               
               
                 211676_s_at 
                 IFNGR1 
                 1.64276331 
                 12.0995889 
                 1.08E−23 
                 1.41E−20 
               
               
                 230966_at 
                 IL4I1 
                 3.68319718 
                 10.6065738 
                 1.18E−23 
                 1.50E−20 
               
               
                 208816_x_at 
                 ANXA2P2 
                 1.61606927 
                 11.6007732 
                 1.33E−23 
                 1.66E−20 
               
               
                 204912_at 
                 IL10RA 
                 1.88097974 
                 10.4596073 
                 1.53E−23 
                 1.83E−20 
               
               
                 220014_at 
                 LOC51334 
                 3.95258058 
                 6.49298277 
                 1.54E−23 
                 1.83E−20 
               
               
                 218856_at 
                 TNFRSF21 
                 1.97277863 
                 11.9973199 
                 2.06E−23 
                 2.40E−20 
               
               
                 34210_at 
                 CD52 
                 1.74841624 
                 11.3194919 
                 2.57E−23 
                 2.92E−20 
               
               
                 211564_s_at 
                 PDLIM4 
                 2.13518707 
                 9.68326105 
                 2.72E−23 
                 3.03E−20 
               
               
                 223502_s_at 
                 TNFSF13B 
                 1.73530598 
                 10.5512407 
                 2.94E−23 
                 3.21E−20 
               
               
                 202727_s_at 
                 IFNGR1 
                 1.5463282 
                 12.4669611 
                 3.25E−23 
                 3.48E−20 
               
               
                 201243_s_at 
                 ATP1B1 
                 2.26738679 
                 11.039008 
                 4.33E−23 
                 4.56E−20 
               
               
                 209606_at 
                 PSCDBP 
                 2.53767762 
                 8.05776375 
                 4.93E−23 
                 5.08E−20 
               
               
                 222670_s_at 
                 MAFB 
                 2.65652588 
                 11.7521547 
                 6.27E−23 
                 6.35E−20 
               
               
                 223394_at 
                 SERTAD1 
                 1.65031524 
                 9.76915308 
                 6.91E−23 
                 6.87E−20 
               
               
                 214175_x_at 
                 PDLIM4 
                 1.85137891 
                 9.80931564 
                 8.66E−23 
                 8.45E−20 
               
               
                 223660_at 
                 ADORA3 
                 1.89720977 
                 9.3830598 
                 9.01E−23 
                 8.64E−20 
               
               
                 203217_s_at 
                 ST3GAL5 
                 1.78903169 
                 9.10901818 
                 1.17E−22 
                 1.11E−19 
               
               
                 204257_at 
                 FADS3 
                 1.78672893 
                 9.74459459 
                 1.23E−22 
                 1.14E−19 
               
               
                 223398_at 
                 C9ORF89 
                 1.54418891 
                 11.0771528 
                 1.25E−22 
                 1.14E−19 
               
               
                 211986_at 
                 AHNAK 
                 1.64967948 
                 12.0209047 
                 1.63E−22 
                 1.45E−19 
               
               
                 201278_at 
                 DAB2 
                 1.56823308 
                 9.36397364 
                 1.64E−22 
                 1.45E−19 
               
               
                 229797_at 
                 MCOLN3 
                 2.09980647 
                 10.05118 
                 2.01E−22 
                 1.75E−19 
               
               
                 202284_s_at 
                 CDKN1A 
                 1.789083 
                 11.1500265 
                 2.69E−22 
                 2.22E−19 
               
               
                 228579_at 
                 — 
                 1.73158064 
                 8.85026747 
                 3.40E−22 
                 2.78E−19 
               
               
                 204653_at 
                 TFAP2A 
                 1.98518712 
                 8.32878609 
                 5.70E−22 
                 4.39E−19 
               
               
                 201952_at 
                 ALCAM 
                 1.52577304 
                 12.9059918 
                 6.14E−22 
                 4.66E−19 
               
               
                 202087_s_at 
                 CTSL 
                 1.91284953 
                 11.1924209 
                 6.47E−22 
                 4.84E−19 
               
               
                 208978_at 
                 CRIP2 
                 1.99640335 
                 10.1060568 
                 6.82E−22 
                 5.04E−19 
               
               
                 219434_at 
                 TREM1 
                 1.77683606 
                 11.1148543 
                 6.95E−22 
                 5.07E−19 
               
               
                 235911_at 
                 MFI2 
                 1.81455526 
                 10.1578351 
                 7.75E−22 
                 5.57E−19 
               
               
                 225173_at 
                 ARHGAP18 
                 1.85956949 
                 10.0159515 
                 7.95E−22 
                 5.65E−19 
               
               
                 204661_at 
                 CD52 
                 1.6752998 
                 11.8608631 
                 9.08E−22 
                 6.28E−19 
               
               
                 202756_s_at 
                 GPC1 
                 1.88792383 
                 8.93231998 
                 9.08E−22 
                 6.28E−19 
               
               
                 227240_at 
                 NGEF 
                 1.97393626 
                 9.35225393 
                 9.96E−22 
                 6.66E−19 
               
               
                 220484_at 
                 MCOLN3 
                 2.10889009 
                 9.93061659 
                 9.98E−22 
                 6.66E−19 
               
               
                 214297_at 
                 CSPG4 
                 1.98668454 
                 8.74794884 
                 9.99E−22 
                 6.66E−19 
               
               
                 203355_s_at 
                 PSD3 
                 1.68707305 
                 9.97354098 
                 1.13E−21 
                 7.47E−19 
               
               
                 212386_at 
                 — 
                 1.80977269 
                 8.4443852 
                 1.22E−21 
                 7.91E−19 
               
               
                 201242_s_at 
                 ATP1B1 
                 2.36020561 
                 10.833866 
                 1.62E−21 
                 1.03E−18 
               
               
                 203760_s_at 
                 SLA 
                 1.76467647 
                 10.2984296 
                 1.71E−21 
                 1.07E−18 
               
               
                 204475_at 
                 MMP1 
                 4.89045646 
                 6.14908101 
                 1.97E−21 
                 1.21E−18 
               
               
                 228964_at 
                 PRDM1 
                 2.42316104 
                 9.16116313 
                 2.05E−21 
                 1.24E−18 
               
               
                 205566_at 
                 ABHD2 
                 1.61609464 
                 9.56280738 
                 2.12E−21 
                 1.27E−18 
               
               
                 224990_at 
                 LOC201895 
                 1.75486717 
                 9.56572435 
                 2.15E−21 
                 1.28E−18 
               
               
                 214830_at 
                 SLC38A6 
                 1.70065597 
                 9.60777602 
                 2.38E−21 
                 1.38E−18 
               
               
                 222876_s_at 
                 CENTA2 
                 1.62337809 
                 9.52111995 
                 3.45E−21 
                 1.92E−18 
               
               
                 218501_at 
                 ARHGEF3 
                 1.72054917 
                 9.02047119 
                 3.66E−21 
                 2.02E−18 
               
               
                 206134_at 
                 ADAMDEC1 
                 1.90734854 
                 8.46538539 
                 3.83E−21 
                 2.10E−18 
               
               
                 219385_at 
                 SLAMF8 
                 2.3601546 
                 8.87175449 
                 4.64E−21 
                 2.49E−18 
               
               
                 212298_at 
                 NRP1 
                 2.26706147 
                 9.0154209 
                 5.27E−21 
                 2.77E−18 
               
               
                 1556314_a_at 
                 — 
                 1.94563197 
                 9.96244884 
                 5.97E−21 
                 3.05E−18 
               
               
                 204834_at 
                 FGL2 
                 2.41220628 
                 9.04212862 
                 7.43E−21 
                 3.63E−18 
               
               
                 227052_at 
                 — 
                 1.7292497 
                 9.65138189 
                 8.49E−21 
                 4.11E−18 
               
               
                 223501_at 
                 — 
                 1.77755998 
                 10.4775991 
                 9.58E−21 
                 4.59E−18 
               
               
                 238669_at 
                 PTGS1 
                 1.79526928 
                 9.00713066 
                 1.52E−20 
                 7.11E−18 
               
               
                 203936_s_at 
                 MMP9 
                 1.83742157 
                 9.54268719 
                 2.01E−20 
                 9.33E−18 
               
               
                 205128_x_at 
                 PTGS1 
                 1.50682893 
                 10.8982825 
                 2.46E−20 
                 1.12E−17 
               
               
                 223019_at 
                 C9ORF88 
                 1.71440506 
                 9.42451447 
                 2.48E−20 
                 1.12E−17 
               
               
                 218223_s_at 
                 PLEKHO1 
                 1.76062083 
                 9.13759715 
                 2.55E−20 
                 1.14E−17 
               
               
                 226545_at 
                 CD109 
                 2.22747108 
                 10.1210564 
                 2.62E−20 
                 1.17E−17 
               
               
                 37145_at 
                 GNLY 
                 2.52474166 
                 7.62618078 
                 2.77E−20 
                 1.21E−17 
               
               
                 211661_x_at 
                 PTAFR 
                 1.65459655 
                 9.40348625 
                 3.20E−20 
                 1.39E−17 
               
               
                 223434_at 
                 GBP3 
                 1.79281477 
                 8.94069901 
                 5.65E−20 
                 2.39E−17 
               
               
                 221011_s_at 
                 LBH /// LOC653743 
                 2.14546482 
                 7.91354368 
                 6.67E−20 
                 2.79E−17 
               
               
                 227478_at 
                 LOC284262 
                 2.55523487 
                 8.16720299 
                 7.57E−20 
                 3.09E−17 
               
               
                 205933_at 
                 SETBP1 
                 2.06852059 
                 8.31470678 
                 9.65E−20 
                 3.88E−17 
               
               
                 223126_s_at 
                 C1ORF21 
                 2.0098249 
                 9.34926366 
                 1.00E−19 
                 3.99E−17 
               
               
                 214255_at 
                 ATP10A 
                 1.87404352 
                 8.48741153 
                 1.17E−19 
                 4.64E−17 
               
               
                 203888_at 
                 THBD 
                 1.74251135 
                 12.1003768 
                 1.32E−19 
                 5.18E−17 
               
               
                 239761_at 
                 GCNT1 
                 1.60737016 
                 9.89061934 
                 1.78E−19 
                 6.90E−17 
               
               
                 205505_at 
                 GCNT1 
                 1.68341734 
                 9.51667582 
                 1.80E−19 
                 6.93E−17 
               
               
                 203665_at 
                 HMOX1 
                 2.77855009 
                 12.0276078 
                 1.83E−19 
                 7.00E−17 
               
               
                 228490_at 
                 ABHD2 
                 1.7612845 
                 9.44137483 
                 1.92E−19 
                 7.27E−17 
               
               
                 213428_s_at 
                 COL6A1 
                 1.6365876 
                 9.11385826 
                 2.21E−19 
                 8.27E−17 
               
               
                 202748_at 
                 GBP2 
                 2.05214857 
                 8.5030424 
                 2.71E−19 
                 1.01E−16 
               
               
                 63825_at 
                 ABHD2 
                 1.60237791 
                 9.12592031 
                 3.53E−19 
                 1.28E−16 
               
               
                 205542_at 
                 STEAP1 
                 1.7513289 
                 7.91561507 
                 4.15E−19 
                 1.49E−16 
               
               
                 215813_s_at 
                 PTGS1 
                 1.51668643 
                 10.9189252 
                 4.31E−19 
                 1.53E−16 
               
               
                 205891_at 
                 ADORA2B 
                 1.56662939 
                 10.2505629 
                 4.70E−19 
                 1.66E−16 
               
               
                 218613_at 
                 LOC653754 
                 1.55398123 
                 9.29556045 
                 4.95E−19 
                 1.73E−16 
               
               
                 205076_s_at 
                 MTMR11 
                 1.59326395 
                 11.2341764 
                 5.05E−19 
                 1.76E−16 
               
               
                 212086_at 
                 LMNA 
                 1.50357006 
                 12.1481348 
                 5.14E−19 
                 1.78E−16 
               
               
                 203104_at 
                 CSF1R 
                 1.64383545 
                 11.9446038 
                 5.33E−19 
                 1.83E−16 
               
               
                 228368_at 
                 ARHGAP20 
                 2.23117651 
                 8.70947261 
                 5.37E−19 
                 1.84E−16 
               
               
                 227889_at 
                 AYTL1 
                 1.59282395 
                 10.8879284 
                 5.43E−19 
                 1.84E−16 
               
               
                 203797_at 
                 VSNL1 
                 1.7623632 
                 9.20419419 
                 5.45E−19 
                 1.84E−16 
               
               
                 210145_at 
                 PLA2G4A 
                 1.69920287 
                 9.86166848 
                 5.50E−19 
                 1.84E−16 
               
               
                 220307_at 
                 CD244 
                 1.51030196 
                 11.2887381 
                 6.64E−19 
                 2.20E−16 
               
               
                 201280_s_at 
                 DAB2 
                 1.6207775 
                 8.250618 
                 7.03E−19 
                 2.30E−16 
               
               
                 205898_at 
                 CX3CR1 
                 1.5834422 
                 12.3392251 
                 7.53E−19 
                 2.45E−16 
               
               
                 212171_x_at 
                 VEGF 
                 1.67886192 
                 11.082533 
                 8.08E−19 
                 2.61E−16 
               
               
                 205419_at 
                 EBI2 
                 1.87963971 
                 10.3117587 
                 8.24E−19 
                 2.64E−16 
               
               
                 242794_at 
                 MAML3 
                 1.71070972 
                 8.2000023 
                 8.71E−19 
                 2.76E−16 
               
               
                 1553141_at 
                 C13ORF31 
                 2.23957531 
                 8.21534882 
                 9.28E−19 
                 2.90E−16 
               
               
                 1556034_s_at 
                 MTMR11 
                 1.54656669 
                 10.734173 
                 9.32E−19 
                 2.90E−16 
               
               
                 202436_s_at 
                 CYP1B1 
                 2.02651623 
                 11.7446834 
                 1.35E−18 
                 4.08E−16 
               
               
                 205718_at 
                 ITGB7 
                 1.61859456 
                 10.0388412 
                 1.64E−18 
                 4.92E−16 
               
               
                 222062_at 
                 IL27RA 
                 1.84145262 
                 8.80213383 
                 1.77E−18 
                 5.26E−16 
               
               
                 1565752_at 
                 FGD2 
                 2.03973925 
                 8.7032554 
                 1.80E−18 
                 5.32E−16 
               
               
                 203140_at 
                 BCL6 
                 1.6321005 
                 9.84693758 
                 1.88E−18 
                 5.54E−16 
               
               
                 209568_s_at 
                 RGL1 
                 1.79068455 
                 9.03375054 
                 2.04E−18 
                 5.92E−16 
               
               
                 212977_at 
                 CXCR7 
                 1.95857569 
                 9.06724806 
                 2.73E−18 
                 7.74E−16 
               
               
                 225809_at 
                 DKEZP564O0823 
                 2.61498482 
                 6.81686881 
                 3.21E−18 
                 8.90E−16 
               
               
                 223723_at 
                 MFI2 
                 1.83918768 
                 7.73004392 
                 3.45E−18 
                 9.49E−16 
               
               
                 204141_at 
                 TUBB2A 
                 1.92337874 
                 7.9645182 
                 3.55E−18 
                 9.72E−16 
               
               
                 219358_s_at 
                 CENTA2 
                 1.61743685 
                 10.3689956 
                 3.67E−18 
                 9.97E−16 
               
               
                 218280_x_at 
                 HIST2H2AA /// LOC653610 ///H2A/R 
                 1.92645343 
                 11.1017962 
                 3.91E−18 
                 1.05E−15 
               
               
                 200884_at 
                 CKB 
                 1.62119168 
                 10.3585418 
                 3.91E−18 
                 1.05E−15 
               
               
                 213265_at 
                 PGA5 /// LOC643834 /// LOC643847 
                 1.54256466 
                 9.03735387 
                 4.18E−18 
                 1.12E−15 
               
               
                 228499_at 
                 PFKFB4 
                 1.54265427 
                 8.78361163 
                 4.58E−18 
                 1.22E−15 
               
               
                 214581_x_at 
                 TNFRSF21 
                 1.96726151 
                 10.3862452 
                 5.13E−18 
                 1.35E−15 
               
               
                 219256_s_at 
                 SH3TC1 
                 1.81211933 
                 8.14371592 
                 5.59E−18 
                 1.46E−15 
               
               
                 227134_at 
                 SYTL1 
                 1.63431503 
                 10.2085878 
                 5.74E−18 
                 1.50E−15 
               
               
                 210512_s_at 
                 VEGF 
                 1.61269337 
                 12.1528461 
                 5.88E−18 
                 1.52E−15 
               
               
                 220066_at 
                 CARD15 
                 1.63208119 
                 8.81134661 
                 6.12E−18 
                 1.58E−15 
               
               
                 207610_s_at 
                 EMR2 
                 1.96904599 
                 7.45239164 
                 6.31E−18 
                 1.62E−15 
               
               
                 225337_at 
                 ABHD2 
                 1.52226303 
                 10.585684 
                 6.47E−18 
                 1.65E−15 
               
               
                 1553906_s_at 
                 FGD2 
                 1.56817402 
                 11.6738144 
                 8.15E−18 
                 2.05E−15 
               
               
                 210757_x_at 
                 DAB2 
                 1.51596174 
                 9.71603785 
                 8.84E−18 
                 2.22E−15 
               
               
                 205306_x_at 
                 KMO 
                 1.52538689 
                 9.01246744 
                 1.07E−17 
                 2.64E−15 
               
               
                 203980_at 
                 FABP4 
                 2.44504844 
                 7.91709543 
                 1.14E−17 
                 2.81E−15 
               
               
                 205798_at 
                 IL7R 
                 2.15224639 
                 6.90018766 
                 1.20E−17 
                 2.94E−15 
               
               
                 235299_at 
                 — 
                 2.92455443 
                 6.38887226 
                 1.23E−17 
                 2.99E−15 
               
               
                 201422_at 
                 IFI30 
                 1.53617841 
                 12.1952 
                 1.33E−17 
                 3.23E−15 
               
               
                 201951_at 
                 ALCAM 
                 1.56151412 
                 11.2835886 
                 1.36E−17 
                 3.29E−15 
               
               
                 219412_at 
                 RAB38 
                 1.69022517 
                 7.7984244 
                 1.40E−17 
                 3.36E−15 
               
               
                 214290_s_at 
                 HIST2H2AA /// LOC653610 /// H2A/R 
                 1.8793137 
                 12.5116024 
                 1.77E−17 
                 4.19E−15 
               
               
                 223092_at 
                 ANKH 
                 1.74621066 
                 9.31182429 
                 1.93E−17 
                 4.53E−15 
               
               
                 1552553_a_at 
                 CARD12 
                 1.8300836 
                 8.04038883 
                 1.98E−17 
                 4.61E−15 
               
               
                 1565754_x_at 
                 FGD2 
                 2.05302245 
                 8.76658914 
                 1.98E−17 
                 4.61E−15 
               
               
                 1562475_at 
                 DKFZP686O1327 
                 1.84932663 
                 8.38987825 
                 2.25E−17 
                 5.18E−15 
               
               
                 202435_s_at 
                 CYP1B1 
                 1.96043252 
                 11.3853309 
                 2.26E−17 
                 5.18E−15 
               
               
                 222877_at 
                 NRP2 
                 2.43002847 
                 6.1162318 
                 2.37E−17 
                 5.41E−15 
               
               
                 201125_s_at 
                 ITGB5 
                 1.55447321 
                 9.61610321 
                 2.48E−17 
                 5.62E−15 
               
               
                 204222_s_at 
                 GLIPR1 
                 1.64989211 
                 10.4691144 
                 3.30E−17 
                 7.31E−15 
               
               
                 1553142_at 
                 C13ORF31 
                 2.72312753 
                 7.05894587 
                 3.42E−17 
                 7.51E−15 
               
               
                 201279_s_at 
                 DAB2 
                 1.51128632 
                 9.36621678 
                 3.53E−17 
                 7.64E−15 
               
               
                 203234_at 
                 UPP1 
                 1.74387737 
                 9.56780561 
                 3.97E−17 
                 8.52E−15 
               
               
                 226136_at 
                 — 
                 1.5023264 
                 9.021618 
                 4.37E−17 
                 9.27E−15 
               
               
                 206206_at 
                 CD180 
                 1.61188665 
                 9.82309399 
                 6.95E−17 
                 1.43E−14 
               
               
                 212387_at 
                 — 
                 1.62401877 
                 7.80816226 
                 1.05E−16 
                 2.07E−14 
               
               
                 204268_at 
                 S100A2 
                 1.79310512 
                 8.64238178 
                 1.22E−16 
                 2.38E−14 
               
               
                 209122_at 
                 ADFP 
                 1.61478632 
                 13.4092966 
                 1.23E−16 
                 2.41E−14 
               
               
                 219994_at 
                 APBB1IP 
                 1.87740546 
                 9.6208094 
                 1.42E−16 
                 2.74E−14 
               
               
                 210095_s_at 
                 IGFBP3 
                 2.98798358 
                 8.63072598 
                 1.43E−16 
                 2.74E−14 
               
               
                 227948_at 
                 FGD4 
                 1.62553487 
                 7.73111329 
                 1.54E−16 
                 2.92E−14 
               
               
                 243483_at 
                 TRPM8 
                 2.13837999 
                 7.16652124 
                 1.62E−16 
                 3.04E−14 
               
               
                 212062_at 
                 ATP9A 
                 2.12888023 
                 7.50745486 
                 1.77E−16 
                 3.29E−14 
               
               
                 218502_s_at 
                 TRPS1 
                 1.61387671 
                 8.89822927 
                 1.95E−16 
                 3.60E−14 
               
               
                 213891_s_at 
                 — 
                 1.67207935 
                 8.30917084 
                 2.03E−16 
                 3.68E−14 
               
               
                 200878_at 
                 EPAS1 
                 1.51714595 
                 9.20362299 
                 2.04E−16 
                 3.69E−14 
               
               
                 201565_s_at 
                 ID2 
                 1.52829092 
                 12.7810873 
                 2.26E−16 
                 4.06E−14 
               
               
                 212190_at 
                 SERPINE2 
                 1.92452066 
                 9.90116936 
                 2.57E−16 
                 4.60E−14 
               
               
                 224480_s_at 
                 LPAAT-THETA 
                 1.96245654 
                 8.74709429 
                 2.64E−16 
                 4.67E−14 
               
               
                 220333_at 
                 PAQR5 
                 3.58344803 
                 7.84174393 
                 2.70E−16 
                 4.76E−14 
               
               
                 218589_at 
                 P2RY5 
                 1.65149795 
                 9.3651465 
                 3.00E−16 
                 5.23E−14 
               
               
                 225166_at 
                 ARHGAP18 
                 1.75622288 
                 7.33398136 
                 3.29E−16 
                 5.64E−14 
               
               
                 226066_at 
                 MITF 
                 1.750697 
                 7.87439597 
                 3.35E−16 
                 5.73E−14 
               
               
                 221211_s_at 
                 C21ORF7 
                 2.08949444 
                 5.978895 
                 3.41E−16 
                 5.80E−14 
               
               
                 225842_at 
                 PHLDA1 
                 2.51724542 
                 8.55236084 
                 3.48E−16 
                 5.89E−14 
               
               
                 1554992_at 
                 RASGRF1 
                 1.56735654 
                 6.94135257 
                 3.77E−16 
                 6.35E−14 
               
               
                 225097_at 
                 HIPK2 
                 1.50753986 
                 10.7130384 
                 3.84E−16 
                 6.45E−14 
               
               
                 212464_s_at 
                 FN1 
                 1.70809888 
                 9.26484812 
                 4.53E−16 
                 7.53E−14 
               
               
                 240076_at 
                 — 
                 1.5987436 
                 8.40204375 
                 4.66E−16 
                 7.73E−14 
               
               
                 203798_s_at 
                 VSNL1 
                 1.91644457 
                 7.87623269 
                 4.84E−16 
                 7.92E−14 
               
               
                 204575_s_at 
                 MMP19 /// LOC652543 
                 1.83367508 
                 7.70439226 
                 4.88E−16 
                 7.96E−14 
               
               
                 204465_s_at 
                 INA 
                 1.60147629 
                 8.20221976 
                 5.17E−16 
                 8.36E−14 
               
               
                 201566_x_at 
                 ID2 /// ID28 
                 1.57371123 
                 10.7833858 
                 5.52E−16 
                 8.87E−14 
               
               
                 230360_at 
                 GLDN 
                 1.98086959 
                 6.74193069 
                 6.80E−16 
                 1.07E−13 
               
               
                 222146_s_at 
                 TCF4 
                 1.54556332 
                 7.51472351 
                 8.25E−16 
                 1.28E−13 
               
               
                 224341_x_at 
                 TLR4 
                 1.7396424 
                 8.97197657 
                 8.61E−16 
                 1.32E−13 
               
               
                 219637_at 
                 ARMC9 
                 1.80286893 
                 7.06720581 
                 8.87E−16 
                 1.35E−13 
               
               
                 211138_s_at 
                 KMO 
                 1.54711526 
                 8.79132849 
                 9.12E−16 
                 1.38E−13 
               
               
                 202437_s_at 
                 CYP1B1 
                 1.80921395 
                 12.1893518 
                 9.54E−16 
                 1.43E−13 
               
               
                 235458_at 
                 HAVCR2 
                 2.48536941 
                 7.7122454 
                 9.75E−16 
                 1.46E−13 
               
               
                 203922_s_at 
                 CYBB 
                 1.58449815 
                 10.3814577 
                 1.07E−15 
                 1.58E−13 
               
               
                 212143_s_at 
                 IGFBP3 
                 2.76854721 
                 7.92968375 
                 1.26E−15 
                 1.82E−13 
               
               
                 227716_at 
                 UBXD5 
                 1.51942114 
                 9.002862 
                 1.28E−15 
                 1.83E−13 
               
               
                 214211_at 
                 FTH1 
                 1.55999567 
                 12.4970466 
                 1.33E−15 
                 1.90E−13 
               
               
                 229004_at 
                 — 
                 1.51039984 
                 9.12368109 
                 1.55E−15 
                 2.18E−13 
               
               
                 202609_at 
                 EPS8 
                 1.5924097 
                 8.52061192 
                 1.82E−15 
                 2.52E−13 
               
               
                 217757_at 
                 A2M 
                 1.67532065 
                 8.4520092 
                 1.98E−15 
                 2.73E−13 
               
               
                 1552798_a_at 
                 TLR4 
                 1.62695353 
                 9.04302518 
                 2.09E−15 
                 2.88E−13 
               
               
                 57715_at 
                 FAM26B 
                 1.79873285 
                 7.75582627 
                 2.40E−15 
                 3.27E−13 
               
               
                 226282_at 
                 — 
                 1.60485814 
                 9.41013847 
                 2.84E−15 
                 3.80E−13 
               
               
                 222838_at 
                 SLAMF7 
                 1.86121844 
                 7.05728625 
                 3.11E−15 
                 4.13E−13 
               
               
                 216442_x_at 
                 FN1 
                 1.69780521 
                 10.1409361 
                 3.73E−15 
                 4.87E−13 
               
               
                 201324_at 
                 EMP1 
                 2.82050293 
                 6.11305975 
                 3.81E−15 
                 4.94E−13 
               
               
                 210264_at 
                 GPR35 
                 1.59109619 
                 9.60072153 
                 3.91E−15 
                 5.05E−13 
               
               
                 222858_s_at 
                 DAPP1 
                 1.6313133 
                 10.6750257 
                 4.54E−15 
                 5.78E−13 
               
               
                 209684_at 
                 RIN2 
                 2.16288563 
                 7.25953396 
                 5.48E−15 
                 6.84E−13 
               
               
                 201069_at 
                 MMP2 
                 1.51386957 
                 8.69855532 
                 6.09E−15 
                 7.55E−13 
               
               
                 204998_s_at 
                 ATF5 
                 1.63500149 
                 10.6267979 
                 6.14E−15 
                 7.60E−13 
               
               
                 202434_s_at 
                 CYP1B1 
                 2.2027314 
                 9.83119314 
                 6.94E−15 
                 8.52E−13 
               
               
                 205099_s_at 
                 CCR1 
                 1.57264838 
                 9.76018397 
                 7.25E−15 
                 8.85E−13 
               
               
                 207233_s_at 
                 MITF 
                 1.66865012 
                 8.30250431 
                 8.03E−15 
                 9.72E−13 
               
               
                 205552_s_at 
                 OAS1 
                 1.79452532 
                 7.29881386 
                 8.53E−15 
                 1.02E−12 
               
               
                 226550_at 
                 — 
                 1.79237731 
                 7.77105086 
                 9.20E−15 
                 1.09E−12 
               
               
                 212090_s_at 
                 MTUS1 
                 1.62315248 
                 8.50418445 
                 9.61E−15 
                 1.13E−12 
               
               
                 222651_s_at 
                 TRPS1 
                 1.5940306 
                 10.0878238 
                 9.64E−15 
                 1.13E−12 
               
               
                 211719_x_at 
                 FN1 
                 1.74293625 
                 10.1007312 
                 9.80E−15 
                 1.15E−12 
               
               
                 227609_at 
                 EPSTI1 
                 1.73531372 
                 7.62913716 
                 1.06E−14 
                 1.24E−12 
               
               
                 1558105_a_at 
                 — 
                 1.89855059 
                 6.81046182 
                 1.07E−14 
                 1.25E−12 
               
               
                 225207_at 
                 PDK4 
                 2.24881528 
                 8.76581849 
                 1.08E−14 
                 1.25E−12 
               
               
                 237160_at 
                 CCDC83 
                 2.26816884 
                 5.8347316 
                 1.15E−14 
                 1.33E−12 
               
               
                 211026_s_at 
                 MGLL 
                 1.80987658 
                 8.99536888 
                 1.33E−14 
                 1.53E−12 
               
               
                 229450_at 
                 — 
                 2.07979683 
                 6.90012377 
                 1.42E−14 
                 1.62E−12 
               
               
                 215602_at 
                 FGD2 
                 2.01984347 
                 7.85983935 
                 1.54E−14 
                 1.74E−12 
               
               
                 228708_at 
                 RAB27B 
                 1.75996236 
                 8.57073526 
                 1.63E−14 
                 1.83E−12 
               
               
                 210258_at 
                 RGS13 
                 2.4181722 
                 5.06675503 
                 1.77E−14 
                 1.97E−12 
               
               
                 210895_s_at 
                 CD86 
                 1.74036933 
                 7.80363779 
                 1.88E−14 
                 2.07E−12 
               
               
                 223672_at 
                 SGIP1 
                 1.58033388 
                 8.69396513 
                 1.96E−14 
                 2.14E−12 
               
               
                 210513_s_at 
                 VEGF 
                 1.62960752 
                 9.66705476 
                 2.08E−14 
                 2.25E−12 
               
               
                 212614_at 
                 ARID5B 
                 1.64330835 
                 6.34592171 
                 2.09E−14 
                 2.26E−12 
               
               
                 1553995_a_at 
                 NT5E 
                 2.06345466 
                 6.49987213 
                 2.17E−14 
                 2.32E−12 
               
               
                 233540_s_at 
                 CDK5RAP2 
                 1.77928193 
                 10.6899414 
                 2.34E−14 
                 2.48E−12 
               
               
                 204059_s_at 
                 ME1 
                 1.78078662 
                 11.5066468 
                 2.46E−14 
                 2.58E−12 
               
               
                 211527_x_at 
                 VEGF 
                 1.68079685 
                 9.90807927 
                 2.48E−14 
                 2.60E−12 
               
               
                 214724_at 
                 DIXDC1 
                 1.55892061 
                 7.67060007 
                 2.63E−14 
                 2.74E−12 
               
               
                 227556_at 
                 NME7 
                 2.07486651 
                 9.31851129 
                 2.92E−14 
                 3.02E−12 
               
               
                 237442_at 
                 APBB1IP 
                 1.97657406 
                 7.17373032 
                 3.09E−14 
                 3.18E−12 
               
               
                 224218_s_at 
                 TRPS1 
                 1.52587932 
                 8.16882094 
                 3.38E−14 
                 3.46E−12 
               
               
                 225188_at 
                 RAPH1 
                 1.90298066 
                 6.31647018 
                 3.68E−14 
                 3.73E−12 
               
               
                 244414_at 
                 MAML2 
                 2.39160043 
                 8.05798482 
                 3.70E−14 
                 3.74E−12 
               
               
                 209906_at 
                 C3AR1 
                 1.62034968 
                 8.32122922 
                 3.73E−14 
                 3.76E−12 
               
               
                 210510_s_at 
                 NRP1 
                 1.56055098 
                 7.3171434 
                 3.77E−14 
                 3.78E−12 
               
               
                 226629_at 
                 SLC43A2 
                 1.57641868 
                 8.50211433 
                 3.97E−14 
                 3.94E−12 
               
               
                 237030_at 
                 ACPP 
                 1.53890938 
                 8.05225501 
                 4.15E−14 
                 4.10E−12 
               
               
                 213338_at 
                 TMEM158 
                 1.73773739 
                 10.7585184 
                 4.18E−14 
                 4.13E−12 
               
               
                 219926_at 
                 POPDC3 
                 2.12181972 
                 6.63647483 
                 5.99E−14 
                 5.68E−12 
               
               
                 200897_s_at 
                 PALLD 
                 1.64882729 
                 8.35346573 
                 6.07E−14 
                 5.74E−12 
               
               
                 208436_s_at 
                 IRF7 
                 1.55075885 
                 8.74418094 
                 6.34E−14 
                 5.96E−12 
               
               
                 228438_at 
                 TRPA1 
                 1.65933581 
                 10.3950167 
                 6.81E−14 
                 6.30E−12 
               
               
                 227747_at 
                 — 
                 1.55198677 
                 7.93194342 
                 6.84E−14 
                 6.32E−12 
               
               
                 1554867_a_at 
                 LOC51334 
                 1.86507425 
                 7.40812044 
                 6.90E−14 
                 6.36E−12 
               
               
                 1563445_x_at 
                 CTSLL3 
                 1.82851184 
                 6.84405898 
                 9.09E−14 
                 8.12E−12 
               
               
                 242903_at 
                 IFNGR1 
                 1.7678462 
                 7.97757472 
                 9.49E−14 
                 8.42E−12 
               
               
                 229900_at 
                 CD109 
                 1.54089288 
                 8.62103824 
                 1.05E−13 
                 9.24E−12 
               
               
                 210495_x_at 
                 FN1 
                 1.61505134 
                 10.0973935 
                 1.07E−13 
                 9.43E−12 
               
               
                 218854_at 
                 SART2 
                 1.54263807 
                 8.36626559 
                 1.13E−13 
                 9.81E−12 
               
               
                 224989_at 
                 — 
                 1.78010467 
                 7.75893731 
                 1.17E−13 
                 1.02E−11 
               
               
                 238638_at 
                 SLC37A2 
                 1.63842433 
                 9.93438242 
                 1.31E−13 
                 1.13E−11 
               
               
                 212382_at 
                 — 
                 1.60505834 
                 7.06996616 
                 1.35E−13 
                 1.15E−11 
               
               
                 209047_at 
                 AQP1 
                 2.44653569 
                 7.84720827 
                 1.38E−13 
                 1.17E−11 
               
               
                 236345_at 
                 TBXAS1 
                 1.66860916 
                 8.46774141 
                 1.40E−13 
                 1.18E−11 
               
               
                 228873_at 
                 COL22A1 
                 1.56093003 
                 7.43196243 
                 1.41E−13 
                 1.19E−11 
               
               
                 239519_at 
                 NRP1 
                 2.19110297 
                 5.55763801 
                 1.43E−13 
                 1.20E−11 
               
               
                 220935_s_at 
                 CDK5RAP2 
                 1.84541222 
                 10.4100106 
                 1.54E−13 
                 1.28E−11 
               
               
                 1560228_at 
                 SNAI3 
                 1.91948596 
                 7.8146015 
                 1.56E−13 
                 1.30E−11 
               
               
                 218934_s_at 
                 HSPB7 
                 1.65040526 
                 8.10534113 
                 2.40E−13 
                 1.90E−11 
               
               
                 210146_x_at 
                 LILRB2 
                 1.9982938 
                 6.76423766 
                 2.86E−13 
                 2.22E−11 
               
               
                 209348_s_at 
                 MAF 
                 1.56472875 
                 8.72338323 
                 3.17E−13 
                 2.42E−11 
               
               
                 1558569_at 
                 LOC645238 
                 1.75050375 
                 7.56283286 
                 3.25E−13 
                 2.47E−11 
               
               
                 243856_at 
                 — 
                 1.73115631 
                 8.03640769 
                 3.81E−13 
                 2.86E−11 
               
               
                 223798_at 
                 SLC41A2 
                 1.94681117 
                 6.54582797 
                 3.90E−13 
                 2.92E−11 
               
               
                 215990_s_at 
                 BCL6 
                 1.50671943 
                 8.04953142 
                 4.81E−13 
                 3.52E−11 
               
               
                 202869_at 
                 OAS1 
                 1.63942747 
                 6.73520018 
                 5.30E−13 
                 3.86E−11 
               
               
                 225631_at 
                 KIAA1706 
                 1.53753899 
                 7.78142994 
                 5.56E−13 
                 4.03E−11 
               
               
                 204116_at 
                 IL2RG 
                 1.53970115 
                 7.99806857 
                 5.88E−13 
                 4.22E−11 
               
               
                 225189_s_at 
                 RAPH1 
                 1.85367315 
                 6.14549622 
                 6.27E−13 
                 4.47E−11 
               
               
                 211066_x_at 
                 PCDHGC3 /// PCDHGB4 /// PCDHGA8 
                 1.58678656 
                 10.4111947 
                 7.90E−13 
                 5.53E−11 
               
               
                   
                 /// PCDHGA12 /// PCDHGC5 /// 
               
               
                   
                 PCDHGC4 /// PCDHGB7 /// PCDHGB6 
               
               
                   
                 /// PCDHGB5 /// PCDHGB3 /// 
               
               
                   
                 PCDHGB2 /// PCDHGB1 /// 
               
               
                   
                 PCDHGA11 /// PCDHGA10 /// 
               
               
                   
                 PCDHGA9 /// PCDHGA7 /// PCDHGA6 
               
               
                   
                 /// PCDHGA5 /// PCDHGA4 /// 
               
               
                   
                 PCDHGA3 /// PCDHGA2 /// PCDHGA1 
               
               
                 221266_s_at 
                 TM7SF4 
                 1.83671444 
                 6.22762311 
                 8.02E−13 
                 5.60E−11 
               
               
                 1560485_at 
                 HIVEP1 
                 1.6480621 
                 6.99003908 
                 8.06E−13 
                 5.62E−11 
               
               
                 204881_s_at 
                 UGCG 
                 1.5102382 
                 9.51481557 
                 8.38E−13 
                 5.83E−11 
               
               
                 235286_at 
                 CKLF 
                 1.61741462 
                 8.34288205 
                 9.26E−13 
                 6.36E−11 
               
               
                 205003_at 
                 DOCK4 
                 1.5112689 
                 8.20388936 
                 1.02E−12 
                 6.92E−11 
               
               
                 218686_s_at 
                 RHBDF1 
                 1.51723286 
                 7.92482272 
                 1.05E−12 
                 7.08E−11 
               
               
                 221565_s_at 
                 FAM26B 
                 1.59642371 
                 7.91366407 
                 1.09E−12 
                 7.32E−11 
               
               
                 206675_s_at 
                 SKIL 
                 1.61042514 
                 7.42083013 
                 1.16E−12 
                 7.69E−11 
               
               
                 242358_at 
                 — 
                 2.20249712 
                 6.04968315 
                 1.24E−12 
                 8.20E−11 
               
               
                 241392_at 
                 TMEM39A 
                 1.61384348 
                 7.05009494 
                 1.87E−12 
                 1.19E−10 
               
               
                 232333_at 
                 MAML2 
                 1.68481156 
                 8.01950459 
                 2.06E−12 
                 1.30E−10 
               
               
                 228762_at 
                 LFNG 
                 1.55190457 
                 9.0403074 
                 2.08E−12 
                 1.31E−10 
               
               
                 242907_at 
                 GBP2 
                 2.14738965 
                 6.03707956 
                 2.72E−12 
                 1.64E−10 
               
               
                 203753_at 
                 TCF4 
                 1.50293289 
                 7.66442858 
                 2.78E−12 
                 1.68E−10 
               
               
                 207542_s_at 
                 AQP1 
                 1.69421791 
                 6.82177348 
                 3.02E−12 
                 1.81E−10 
               
               
                 242157_at 
                 — 
                 1.57383098 
                 8.76647265 
                 3.26E−12 
                 1.94E−10 
               
               
                 204058_at 
                 ME1 
                 1.73420796 
                 9.51508263 
                 3.53E−12 
                 2.08E−10 
               
               
                 209921_at 
                 SLC7A11 
                 1.94348494 
                 9.29226579 
                 3.63E−12 
                 2.13E−10 
               
               
                 211030_s_at 
                 SLC6A6 
                 1.51035569 
                 7.57360907 
                 3.78E−12 
                 2.21E−10 
               
               
                 209392_at 
                 ENPP2 
                 1.82310668 
                 5.23034508 
                 4.76E−12 
                 2.73E−10 
               
               
                 243894_at 
                 SLC41A2 
                 1.69547735 
                 5.15085274 
                 4.80E−12 
                 2.75E−10 
               
               
                 229937_x_at 
                 LILRB1 
                 1.58545389 
                 7.41501062 
                 5.00E−12 
                 2.84E−10 
               
               
                 214857_at 
                 C10ORF95 
                 1.60255368 
                 7.13065345 
                 5.02E−12 
                 2.85E−10 
               
               
                 230944_at 
                 MGC45491 
                 1.55203348 
                 7.47887362 
                 5.53E−12 
                 3.14E−10 
               
               
                 228057_at 
                 DDIT4L 
                 1.68290143 
                 9.61033195 
                 6.99E−12 
                 3.82E−10 
               
               
                 204105_s_at 
                 NRCAM 
                 2.27634648 
                 6.95288228 
                 7.49E−12 
                 4.07E−10 
               
               
                 205681_at 
                 BCL2A1 
                 1.64702983 
                 9.50173198 
                 8.19E−12 
                 4.40E−10 
               
               
                 242405_at 
                 MAML2 
                 1.86052011 
                 7.15057318 
                 1.10E−11 
                 5.73E−10 
               
               
                 217678_at 
                 SLC7A11 
                 1.75913555 
                 8.8692241 
                 1.22E−11 
                 6.25E−10 
               
               
                 211962_s_at 
                 ZFP36L1 
                 1.59912563 
                 8.8232205 
                 1.23E−11 
                 6.27E−10 
               
               
                 221060_s_at 
                 TLR4 
                 1.53812487 
                 8.81340284 
                 2.27E−11 
                 1.08E−09 
               
               
                 200907_s_at 
                 PALLD 
                 1.50739688 
                 7.44132987 
                 2.28E−11 
                 1.08E−09 
               
               
                 228918_at 
                 SLC43A2 
                 1.66364865 
                 7.20166079 
                 2.29E−11 
                 1.09E−09 
               
               
                 1555606_a_at 
                 GDPD1 
                 1.51121338 
                 6.61034166 
                 2.39E−11 
                 1.13E−09 
               
               
                 228450_at 
                 PLEKHA7 
                 1.50941089 
                 6.45253703 
                 2.70E−11 
                 1.26E−09 
               
               
                 229221_at 
                 — 
                 1.60263592 
                 8.59003199 
                 4.03E−11 
                 1.79E−09 
               
               
                 229635_at 
                 LOC643424 
                 1.53074512 
                 7.55215178 
                 4.38E−11 
                 1.94E−09 
               
               
                 1569149_at 
                 PDLIM7 
                 1.54849621 
                 9.14969141 
                 5.56E−11 
                 2.41E−09 
               
               
                 207433_at 
                 IL10 
                 1.52400243 
                 5.63708634 
                 7.49E−11 
                 3.14E−09 
               
               
                 221815_at 
                 ABHD2 
                 1.55904737 
                 8.11542769 
                 1.01E−10 
                 4.08E−09 
               
               
                 203060_s_at 
                 PAPSS2 
                 1.5764103 
                 7.75963014 
                 1.25E−10 
                 4.94E−09 
               
               
                 232746_at 
                 CXCR7 
                 2.0719893 
                 6.54641126 
                 1.43E−10 
                 5.55E−09 
               
               
                 1560960_at 
                 MDGA1 
                 1.97885133 
                 5.71541524 
                 1.47E−10 
                 5.70E−09 
               
               
                 234645_at 
                 MAML2 
                 1.87005824 
                 6.53786268 
                 1.72E−10 
                 6.50E−09 
               
               
                 223596_at 
                 SLC12A6 
                 1.50709112 
                 7.32492551 
                 1.75E−10 
                 6.60E−09 
               
               
                 87100_at 
                 ABHD2 
                 1.51939681 
                 7.38326685 
                 1.79E−10 
                 6.75E−09 
               
               
                 213931_at 
                 ID2 /// ID2B 
                 2.71874933 
                 9.84931953 
                 1.87E−10 
                 7.02E−09 
               
               
                 216874_at 
                 DKFZP686O1327 
                 1.70886875 
                 5.93467446 
                 2.11E−10 
                 7.76E−09 
               
               
                 244375_at 
                 EVL 
                 1.56523772 
                 7.93537524 
                 2.24E−10 
                 8.16E−09 
               
               
                 1569150_x_at 
                 PDLIM7 
                 1.54117409 
                 9.37943359 
                 2.24E−10 
                 8.18E−09 
               
               
                 214453_s_at 
                 IFI44 
                 1.79674041 
                 6.65852583 
                 2.78E−10 
                 9.87E−09 
               
               
                 204999_s_at 
                 ATF5 
                 1.64452594 
                 9.14215678 
                 3.41E−10 
                 1.18E−08 
               
               
                 215836_s_at 
                 PCDHGC3 /// PCDHGB4 /// PCDHGA8 
                 1.52441384 
                 9.29079122 
                 4.72E−10 
                 1.60E−08 
               
               
                   
                 /// PCDHGA12 /// PCDHGC5 /// 
               
               
                   
                 PCDHGC4 /// PCDHGB7 /// PCDHGB6 
               
               
                   
                 /// PCDHGB5 /// PCDHGB3 /// 
               
               
                   
                 PCDHGB2 /// PCDHGB1 /// 
               
               
                   
                 PCDHGA11 /// PCDHGA10 /// 
               
               
                   
                 PCDHGA9 /// PCDHGA7 /// PCDHGA6 
               
               
                   
                 /// PCDHGA5 /// PCDHGA4 /// 
               
               
                   
                 PCDHGA3 /// PCDHGA2 /// PCDHGA1 
               
               
                 208161_s_at 
                 ABCC3 
                 1.61726316 
                 8.40189868 
                 5.05E−10 
                 1.69E−08 
               
               
                 202827_s_at 
                 MMP14 
                 1.62314882 
                 10.2030389 
                 5.39E−10 
                 1.78E−08 
               
               
                 208712_at 
                 CCND1 
                 1.5393933 
                 7.40438263 
                 6.16E−10 
                 2.01E−08 
               
               
                 223939_at 
                 SUCNR1 
                 1.57537424 
                 8.40597144 
                 7.17E−10 
                 2.32E−08 
               
               
                 205960_at 
                 PDK4 
                 1.69465703 
                 7.19094792 
                 1.28E−09 
                 3.84E−08 
               
               
                 214841_at 
                 CNIH3 
                 1.56253317 
                 6.14111085 
                 1.40E−09 
                 4.15E−08 
               
               
                 209993_at 
                 ABCB1 
                 1.58407983 
                 5.06880643 
                 1.52E−09 
                 4.48E−08 
               
               
                 1557938_s_at 
                 PTRF 
                 1.50339198 
                 6.8700736 
                 1.62E−09 
                 4.73E−08 
               
               
                 232068_s_at 
                 TLR4 
                 1.74396268 
                 6.76798691 
                 1.84E−09 
                 5.28E−08 
               
               
                 242321_at 
                 — 
                 1.6662739 
                 6.52856887 
                 2.12E−09 
                 5.99E−08 
               
               
                 219574_at 
                 MARCH1 
                 1.64000788 
                 5.55000344 
                 3.54E−09 
                 9.43E−08 
               
               
                 202638_s_at 
                 ICAM1 
                 1.58753294 
                 6.72394157 
                 3.76E−09 
                 9.97E−08 
               
               
                 219496_at 
                 ANKRD57 
                 1.50970429 
                 7.47583744 
                 4.86E−09 
                 1.26E−07 
               
               
                 1555756_a_at 
                 CLEC7A 
                 1.65932872 
                 7.0882743 
                 5.25E−09 
                 1.35E−07 
               
               
                 241929_at 
                 CD36 
                 1.82152709 
                 8.32014251 
                 5.66E−09 
                 1.44E−07 
               
               
                 1556423_at 
                 VASH1 
                 1.55220936 
                 7.02874938 
                 8.01E−09 
                 1.97E−07 
               
               
                 229435_at 
                 GLIS3 
                 1.5824943 
                 4.92660385 
                 8.07E−09 
                 1.98E−07 
               
               
                 217997_at 
                 PHLDA1 
                 2.01871208 
                 7.37991533 
                 8.18E−09 
                 2.00E−07 
               
               
                 235944_at 
                 HMCN1 
                 1.51434592 
                 7.331681 
                 9.15E−09 
                 2.21E−07 
               
               
                 206637_at 
                 P2RY14 
                 1.69022854 
                 4.58701985 
                 9.57E−09 
                 2.30E−07 
               
               
                 213293_s_at 
                 TRiM22 
                 1.54165851 
                 6.59931282 
                 9.57E−09 
                 2.30E−07 
               
               
                 238581_at 
                 GBP5 
                 1.57383447 
                 7.67594481 
                 1.03E−08 
                 2.46E−07 
               
               
                 1558404_at 
                 LOC644242 /// LOC650429 /// 
                 1.85121181 
                 5.31545142 
                 1.46E−08 
                 3.35E−07 
               
               
                   
                 LOC650446 
               
               
                 230559_x_at 
                 FGD4 
                 1.51987215 
                 5.45151267 
                 1.69E−08 
                 3.83E−07 
               
               
                 1553151_at 
                 ATP6V0D2 
                 1.52950999 
                 6.78084809 
                 1.69E−08 
                 3.84E−07 
               
               
                 1554285_at 
                 HAVCR2 
                 1.64907555 
                 7.49492704 
                 3.00E−08 
                 6.38E−07 
               
               
                 244579_at 
                 TRPS1 
                 1.5354261 
                 8.45494277 
                 5.93E−08 
                 1.16E−06 
               
               
                 228640_at 
                 — 
                 1.5809974 
                 4.58101232 
                 7.52E−08 
                 1.43E−06 
               
               
                 210004_at 
                 OLR1 
                 1.59400178 
                 5.26939608 
                 8.40E−08 
                 1.58E−06 
               
               
                 243556_at 
                 NGEF 
                 1.50840974 
                 6.73352627 
                 1.18E−07 
                 2.14E−06 
               
               
                 210360_s_at 
                 MTSS1 
                 1.7452905 
                 6.18923946 
                 1.40E−07 
                 2.49E−06 
               
               
                 217999_s_at 
                 PHLDA1 
                 1.73310668 
                 6.08679858 
                 2.07E−07 
                 3.52E−06 
               
               
                 227062_at 
                 TNCRNA 
                 1.56840333 
                 10.0441571 
                 2.18E−07 
                 3.69E−06 
               
               
                 237904_at 
                 ADORA3 
                 1.52521897 
                 6.15098521 
                 2.49E−07 
                 4.15E−06 
               
               
                 1563621_at 
                 KIAA1706 
                 1.55572929 
                 7.60284745 
                 6.48E−07 
                 9.74E−06 
               
             
          
           
               
                 Down regulated: 
               
             
          
           
               
                 207725_at 
                 POU4F2 
                 −2.8001105 
                 9.19852692 
                 2.12E−22 
                 1.81E−19 
               
               
                 212993_at 
                 — 
                 −1.8809512 
                 9.86599984 
                 2.25E−22 
                 1.89E−19 
               
               
                 211421_s_at 
                 RET 
                 −2.0125505 
                 9.36968529 
                 3.53E−22 
                 2.84E−19 
               
               
                 227899_at 
                 VIT 
                 −1.8754322 
                 7.70929876 
                 4.25E−22 
                 3.36E−19 
               
               
                 225224_at 
                 C20ORF112 
                 −2.04379 
                 8.5964785 
                 1.37E−21 
                 8.79E−19 
               
               
                 213361_at 
                 TDRD7 
                 −1.8488643 
                 10.2732718 
                 2.93E−21 
                 1.67E−18 
               
               
                 214539_at 
                 SERPINB10 
                 −2.1313083 
                 8.01802953 
                 3.16E−21 
                 1.78E−18 
               
               
                 235275_at 
                 OXCT2 
                 −2.0229254 
                 12.4009174 
                 4.06E−21 
                 2.20E−18 
               
               
                 203685_at 
                 BCL2 
                 −2.3112793 
                 8.44431889 
                 4.88E−21 
                 2.59E−18 
               
               
                 227037_at 
                 LOC201164 
                 −1.5468442 
                 9.38990462 
                 5.65E−21 
                 2.94E−18 
               
               
                 219714_s_at 
                 CACNA2D3 
                 −2.206206 
                 9.82724428 
                 5.72E−21 
                 2.95E−18 
               
               
                 206643_at 
                 HAL 
                 −1.9307917 
                 9.28853464 
                 6.18E−21 
                 3.10E−18 
               
               
                 211144_x_at 
                 TRGC2 /// TRGV2 /// TRGV9 /// TARP 
                 −1.5748474 
                 10.586818 
                 7.12E−21 
                 3.54E−18 
               
               
                   
                 /// LOC642083 
               
               
                 217521_at 
                 — 
                 −1.7887534 
                 8.38380263 
                 7.38E−21 
                 3.63E−18 
               
               
                 208206_s_at 
                 RASGRP2 
                 −1.9706562 
                 9.9264082 
                 1.25E−20 
                 5.95E−18 
               
               
                 228977_at 
                 IL17D 
                 −2.1132305 
                 7.51309566 
                 2.19E−20 
                 1.01E−17 
               
               
                 209813_x_at 
                 TRGC2 /// TRGV2 /// TRGV9 /// TARP 
                 −1.6036338 
                 10.7697475 
                 3.87E−20 
                 1.65E−17 
               
               
                   
                 /// LOC642083 
               
               
                 204614_at 
                 SERPINB2 
                 −2.3610663 
                 10.8353035 
                 6.10E−20 
                 2.57E−17 
               
               
                 212110_at 
                 SLC39A14 
                 −1.682778 
                 10.5673949 
                 7.23E−20 
                 3.00E−17 
               
               
                 202444_s_at 
                 SPFH1 
                 −1.8415073 
                 9.34800962 
                 7.37E−20 
                 3.03E−17 
               
               
                 216920_s_at 
                 TRGC2 /// TRGV2 /// TRGV9 /// TARP 
                 −1.5704575 
                 11.3491957 
                 8.78E−20 
                 3.56E−17 
               
               
                   
                 /// LOC642083 
               
               
                 202441_at 
                 SPFH1 
                 −1.6532676 
                 11.1411892 
                 1.45E−19 
                 5.66E−17 
               
               
                 211919_s_at 
                 CXCR4 
                 −1.5387599 
                 11.0738986 
                 3.40E−19 
                 1.25E−16 
               
               
                 204610_s_at 
                 CCDC85B 
                 −1.729942 
                 9.65009386 
                 6.61E−19 
                 2.20E−16 
               
               
                 200999_s_at 
                 CKAP4 
                 −1.6192589 
                 11.5934013 
                 8.23E−19 
                 2.64E−16 
               
               
                 207865_s_at 
                 BMP8B 
                 −2.145585 
                 9.11410521 
                 9.38E−19 
                 2.90E−16 
               
               
                 217028_at 
                 CXCR4 
                 −1.5274428 
                 11.5438714 
                 1.14E−18 
                 3.50E−16 
               
               
                 201968_s_at 
                 PGM1 
                 −1.5051483 
                 9.06546368 
                 2.12E−18 
                 6.10E−16 
               
               
                 219463_at 
                 C20ORF103 
                 −1.5731957 
                 10.0186106 
                 2.55E−18 
                 7.26E−16 
               
               
                 212242_at 
                 TUBA1 
                 −1.5626324 
                 11.2879097 
                 2.82E−18 
                 7.96E−16 
               
               
                 213484_at 
                 — 
                 −1.5736546 
                 8.53538561 
                 3.16E−18 
                 8.83E−16 
               
               
                 209201_x_at 
                 CXCR4 
                 −1.5448129 
                 11.1194624 
                 3.16E−18 
                 8.83E−16 
               
               
                 218858_at 
                 DEPDC6 
                 −1.7866919 
                 7.55045943 
                 5.06E−18 
                 1.34E−15 
               
               
                 202236_s_at 
                 SLC16A1 
                 −1.5384699 
                 10.1675739 
                 9.26E−18 
                 2.30E−15 
               
               
                 208158_s_at 
                 OSBPL1A 
                 −1.6142678 
                 8.3746552 
                 1.71E−17 
                 4.06E−15 
               
               
                 202932_at 
                 YES1 
                 −1.6455703 
                 8.57014581 
                 2.47E−17 
                 5.62E−15 
               
               
                 243209_at 
                 KCNQ4 
                 −2.2463943 
                 6.9665965 
                 2.56E−17 
                 5.79E−15 
               
               
                 215806_x_at 
                 TRGC2 /// TRGV2 /// TRGV9 /// TARP 
                 −1.5328764 
                 11.0634752 
                 3.51E−17 
                 7.61E−15 
               
               
                   
                 /// LOC642083 
               
               
                 204521_at 
                 C12ORF24 
                 −1.5676281 
                 10.1844282 
                 3.88E−17 
                 8.36E−15 
               
               
                 204301_at 
                 KBTBD11 
                 −1.5574513 
                 10.253905 
                 4.37E−17 
                 9.27E−15 
               
               
                 227920_at 
                 KIAA1553 
                 −1.6307063 
                 8.01525239 
                 5.17E−17 
                 1.09E−14 
               
               
                 218251_at 
                 MID1IP1 
                 −1.559714 
                 9.78570246 
                 5.29E−17 
                 1.11E−14 
               
               
                 212646_at 
                 RFTN1 
                 −1.658315 
                 8.57843565 
                 5.38E−17 
                 1.12E−14 
               
               
                 222799_at 
                 HSPC049 
                 −1.5489442 
                 8.60085628 
                 1.10E−16 
                 2.17E−14 
               
               
                 227103_s_at 
                 MGC2408 
                 −1.581709 
                 8.7267591 
                 1.30E−16 
                 2.51E−14 
               
               
                 206067_s_at 
                 WT1 
                 −1.511783 
                 9.85618462 
                 1.37E−16 
                 2.66E−14 
               
               
                 214369_s_at 
                 RASGRP2 
                 −1.5808582 
                 9.41805033 
                 1.69E−16 
                 3.15E−14 
               
               
                 206589_at 
                 GFI1 
                 −1.5996464 
                 11.7281473 
                 1.99E−16 
                 3.65E−14 
               
               
                 225619_at 
                 SLAIN1 
                 −2.2453889 
                 7.41012008 
                 2.01E−16 
                 3.68E−14 
               
               
                 212660_at 
                 PHF15 
                 −1.69531 
                 8.00752875 
                 2.63E−16 
                 4.66E−14 
               
               
                 218971_s_at 
                 HSPC049 
                 −1.5087203 
                 9.12721477 
                 3.08E−16 
                 5.33E−14 
               
               
                 201690_s_at 
                 TPD52 
                 −1.5492402 
                 9.27038373 
                 3.25E−16 
                 5.59E−14 
               
               
                 229638_at 
                 IRX3 
                 −1.6570492 
                 11.8844594 
                 3.38E−16 
                 5.76E−14 
               
               
                 223062_s_at 
                 PSAT1 
                 −1.556602 
                 9.43823571 
                 4.70E−16 
                 7.77E−14 
               
               
                 225510_at 
                 OAF 
                 −1.6632727 
                 10.1142626 
                 6.67E−16 
                 1.05E−13 
               
               
                 209485_s_at 
                 OSBPL1A 
                 −1.6049308 
                 8.36910929 
                 7.34E−16 
                 1.15E−13 
               
               
                 204432_at 
                 SOX12 
                 −1.7584476 
                 6.5781916 
                 8.71E−16 
                 1.33E−13 
               
               
                 205768_s_at 
                 SLC27A2 
                 −1.6303006 
                 7.69181894 
                 8.98E−16 
                 1.36E−13 
               
               
                 211576_s_at 
                 SLC19A1 
                 −1.5339487 
                 9.8247482 
                 9.81E−16 
                 1.46E−13 
               
               
                 201688_s_at 
                 TPD52 
                 −1.6048433 
                 8.65393713 
                 9.93E−16 
                 1.48E−13 
               
               
                 50314_i_at 
                 C20ORF27 
                 −1.561172 
                 9.67877203 
                 1.14E−15 
                 1.66E−13 
               
               
                 1553436_at 
                 MUC19 
                 −1.64037 
                 7.99717726 
                 1.18E−15 
                 1.71E−13 
               
               
                 202800_at 
                 SLC1A3 
                 −1.5176496 
                 8.18097955 
                 1.51E−15 
                 2.13E−13 
               
               
                 41037_at 
                 TEAD4 
                 −1.6405647 
                 6.31029525 
                 1.70E−15 
                 2.36E−13 
               
               
                 216953_s_at 
                 WT1 
                 −1.5276508 
                 7.76890727 
                 2.15E−15 
                 2.95E−13 
               
               
                 228055_at 
                 NAPSB 
                 −1.5385754 
                 10.1648177 
                 2.61E−15 
                 3.52E−13 
               
               
                 218424_s_at 
                 STEAP3 
                 −1.7692882 
                 7.88028032 
                 2.78E−15 
                 3.74E−13 
               
               
                 212855_at 
                 DCUN1D4 
                 −1.508562 
                 7.88887861 
                 2.92E−15 
                 3.90E−13 
               
               
                 202933_s_at 
                 YES1 
                 −1.5437793 
                 9.12374841 
                 3.76E−15 
                 4.89E−13 
               
               
                 1553138_a_at 
                 ANKRD41 
                 −2.0146608 
                 6.96935627 
                 6.26E−15 
                 7.73E−13 
               
               
                 227242_s_at 
                 EBF3 
                 −1.8363477 
                 4.86769268 
                 8.15E−15 
                 9.84E−13 
               
               
                 237265_at 
                 C16ORF73 
                 −1.5296704 
                 9.74165113 
                 9.60E−15 
                 1.13E−12 
               
               
                 213478_at 
                 KIAA1026 
                 −1.8330762 
                 7.39399329 
                 1.16E−14 
                 1.34E−12 
               
               
                 225081_s_at 
                 CDCA7L 
                 −1.5491727 
                 10.2951966 
                 1.46E−14 
                 1.66E−12 
               
               
                 211299_s_at 
                 FLOT2 
                 −1.6145204 
                 9.10864173 
                 1.58E−14 
                 1.79E−12 
               
               
                 213568_at 
                 OSR2 
                 −2.2462672 
                 5.99962469 
                 1.64E−14 
                 1.83E−12 
               
               
                 227662_at 
                 SYNPO2 
                 −1.5973696 
                 8.62811124 
                 1.76E−14 
                 1.96E−12 
               
               
                 200998_s_at 
                 CKAP4 
                 −1.6910951 
                 9.77491302 
                 2.08E−14 
                 2.25E−12 
               
               
                 209900_s_at 
                 SLC16A1 
                 −1.5885969 
                 7.84437981 
                 2.30E−14 
                 2.43E−12 
               
               
                 229084_at 
                 CNTN4 
                 −1.6415136 
                 7.72735571 
                 2.30E−14 
                 2.43E−12 
               
               
                 238694_at 
                 — 
                 −1.5762461 
                 7.26420148 
                 3.38E−14 
                 3.46E−12 
               
               
                 1555788_a_at 
                 TRIB3 
                 −1.5022329 
                 9.92495817 
                 3.64E−14 
                 3.70E−12 
               
               
                 221900_at 
                 COL8A2 
                 −1.5627579 
                 10.2358313 
                 4.09E−14 
                 4.05E−12 
               
               
                 225016_at 
                 APCDD1 
                 −1.6872345 
                 6.47036912 
                 4.21E−14 
                 4.14E−12 
               
               
                 225768_at 
                 NR1D2 
                 −1.7351352 
                 6.8044854 
                 5.44E−14 
                 5.24E−12 
               
               
                 222095_s_at 
                 C1ORF76 
                 −1.7301956 
                 7.38672115 
                 6.40E−14 
                 6.00E−12 
               
               
                 229103_at 
                 WNT3 
                 −1.7749895 
                 5.55503782 
                 7.97E−14 
                 7.21E−12 
               
               
                 205769_at 
                 SLC27A2 
                 −1.7824201 
                 7.67753108 
                 1.53E−13 
                 1.27E−11 
               
               
                 201689_s_at 
                 TPD52 
                 −1.645479 
                 8.12663653 
                 1.59E−13 
                 1.31E−11 
               
               
                 201350_at 
                 FLOT2 
                 −1.5079906 
                 11.0344892 
                 2.08E−13 
                 1.68E−11 
               
               
                 221648_s_at 
                 C1ORF121 
                 −1.517313 
                 8.36815023 
                 2.55E−13 
                 2.00E−11 
               
               
                 208078_s_at 
                 SNF1LK 
                 −1.597736 
                 7.64505173 
                 2.81E−13 
                 2.18E−11 
               
               
                 1562484_at 
                 FLJ35848 
                 −1.9050209 
                 6.65405977 
                 3.15E−13 
                 2.41E−11 
               
               
                 1555370_a_at 
                 CAMTA1 
                 −1.7040191 
                 6.36041757 
                 3.26E−13 
                 2.47E−11 
               
               
                 218376_s_at 
                 MICAL1 
                 −1.5055354 
                 11.194367 
                 3.44E−13 
                 2.61E−11 
               
               
                 204567_s_at 
                 ABCG1 
                 −1.8330717 
                 5.8226155 
                 3.51E−13 
                 2.66E−11 
               
               
                 39966_at 
                 CSPG5 
                 −1.6105172 
                 7.68266153 
                 4.12E−13 
                 3.07E−11 
               
               
                 218326_s_at 
                 LGR4 
                 −1.696564 
                 6.525917 
                 5.28E−13 
                 3.85E−11 
               
               
                 212430_at 
                 RBM38 
                 −1.5884137 
                 8.88476901 
                 5.78E−13 
                 4.17E−11 
               
               
                 227236_at 
                 TSPAN2 
                 −1.7695047 
                 6.98434119 
                 7.37E−13 
                 5.19E−11 
               
               
                 204794_at 
                 DUSP2 
                 −1.5957268 
                 8.45706393 
                 7.96E−13 
                 5.57E−11 
               
               
                 230888_at 
                 HSPC049 
                 −1.577802 
                 7.20584208 
                 9.14E−13 
                 6.29E−11 
               
               
                 212097_at 
                 CAV1 
                 −1.6628831 
                 7.59130877 
                 9.63E−13 
                 6.57E−11 
               
               
                 209353_s_at 
                 C1ORF76 
                 −1.7131519 
                 7.30778535 
                 1.02E−12 
                 6.92E−11 
               
               
                 201801_s_at 
                 SLC29A1 
                 −1.6246978 
                 8.73200853 
                 1.05E−12 
                 7.08E−11 
               
               
                 210279_at 
                 GPR18 
                 −1.5350315 
                 8.98079125 
                 1.29E−12 
                 8.49E−11 
               
               
                 52651_at 
                 COL8A2 
                 −1.577706 
                 9.9516637 
                 1.31E−12 
                 8.57E−11 
               
               
                 235758_at 
                 PNMA6A 
                 −1.5784572 
                 7.86091427 
                 1.34E−12 
                 8.77E−11 
               
               
                 222162_s_at 
                 ADAMTS1 
                 −1.842254 
                 6.45805339 
                 1.37E−12 
                 8.95E−11 
               
               
                 209369_at 
                 ANXA3 
                 −1.7449323 
                 5.34631362 
                 1.41E−12 
                 9.18E−11 
               
               
                 219911_s_at 
                 SLCO4A1 
                 −1.5143987 
                 8.17455361 
                 1.50E−12 
                 9.71E−11 
               
               
                 1557919_a_at 
                 LOC648232 
                 −1.5028156 
                 12.5466889 
                 1.73E−12 
                 1.11E−10 
               
               
                 219497_s_at 
                 BCL11A 
                 −1.5825853 
                 9.14635109 
                 1.85E−12 
                 1.18E−10 
               
               
                 232271_at 
                 HNF4G 
                 −1.5978388 
                 7.3715225 
                 2.04E−12 
                 1.29E−10 
               
               
                 206653_at 
                 — 
                 −1.5611734 
                 6.70426513 
                 2.13E−12 
                 1.33E−10 
               
               
                 225782_at 
                 MSRB3 
                 −1.5020089 
                 8.17316381 
                 2.54E−12 
                 1.55E−10 
               
               
                 223704_s_at 
                 DMRT2 
                 −1.6370445 
                 6.61601092 
                 5.67E−12 
                 3.20E−10 
               
               
                 1558613_at 
                 OAF 
                 −1.5776535 
                 7.5183993 
                 6.15E−12 
                 3.44E−10 
               
               
                 1555434_a_at 
                 SLC39A14 
                 −1.5483414 
                 7.91388969 
                 6.58E−12 
                 3.65E−10 
               
               
                 1556194_a_at 
                 — 
                 −1.7264827 
                 7.80933003 
                 1.10E−11 
                 5.73E−10 
               
               
                 219304_s_at 
                 PDGFD 
                 −1.5313053 
                 8.14849618 
                 1.10E−11 
                 5.73E−10 
               
               
                 200894_s_at 
                 FKBP4 
                 −1.6280907 
                 8.06454238 
                 1.28E−11 
                 6.49E−10 
               
               
                 210347_s_at 
                 BCL11A 
                 −1.5419287 
                 7.82101671 
                 1.36E−11 
                 6.85E−10 
               
               
                 221249_s_at 
                 FAM117A 
                 −1.5920148 
                 8.42643515 
                 1.45E−11 
                 7.21E−10 
               
               
                 239410_at 
                 — 
                 −1.521547 
                 6.86497836 
                 1.72E−11 
                 8.46E−10 
               
               
                 206039_at 
                 RAB33A 
                 −1.5487461 
                 8.85562976 
                 2.20E−11 
                 1.05E−09 
               
               
                 1554660_a_at 
                 C1ORF71 
                 −1.5203911 
                 7.61313106 
                 2.54E−11 
                 1.19E−09 
               
               
                 209776_s_at 
                 SLC19A1 
                 −1.5451778 
                 7.72495148 
                 2.90E−11 
                 1.34E−09 
               
               
                 1560495_at 
                 — 
                 −1.6478409 
                 7.28259363 
                 3.01E−11 
                 1.386−09 
               
               
                 202234_s_at 
                 SLC16A1 
                 −1.5891823 
                 7.76240785 
                 4.97E−11 
                 2.16E−09 
               
               
                 207768_at 
                 EGR4 
                 −2.266679 
                 5.08097601 
                 7.18E−11 
                 3.02E−09 
               
               
                 207717_s_at 
                 PKP2 
                 −1.5155863 
                 4.5970225 
                 1.26E−10 
                 4.97E−09 
               
               
                 213912_at 
                 KIAA0984 
                 −1.5617265 
                 6.49154577 
                 1.30E−10 
                 5.13E−09 
               
               
                 222891_s_at 
                 BCL11A 
                 −1.5929549 
                 8.42933212 
                 2.00E−10 
                 7.44E−09 
               
               
                 213268_at 
                 CAMTA1 
                 −1.7460973 
                 5.75010725 
                 2.03E−10 
                 7.52E−09 
               
               
                 232007_at 
                 — 
                 −1.5199738 
                 9.70608088 
                 2.60E−10 
                 9.33E−09 
               
               
                 227099_s_at 
                 LOC387763 
                 −1.5087957 
                 6.4279952 
                 2.97E−10 
                 1.05E−08 
               
               
                 232614_at 
                 BCL2 
                 −1.6221488 
                 7.30276639 
                 2.99E−10 
                 1.05E−08 
               
               
                 222668_at 
                 KCTD15 
                 −1.5400712 
                 5.79509816 
                 3.31E−10 
                 1.15E−08 
               
               
                 213610_s_at 
                 KLHL23 
                 −1.5730988 
                 7.2326013 
                 4.60E−10 
                 1.56E−08 
               
               
                 206935_at 
                 PCDH8 
                 −1.6992238 
                 5.66380311 
                 6.65E−10 
                 2.16E−08 
               
               
                 203708_at 
                 PDE4B 
                 −1.5144333 
                 7.44164625 
                 8.10E−10 
                 2.59E−08 
               
               
                 1554298_a_at 
                 WDR49 
                 −1.5642625 
                 6.77053726 
                 8.63E−10 
                 2.73E−08 
               
               
                 212558_at 
                 SPRY1 
                 −1.6087624 
                 5.95823849 
                 1.41E−09 
                 4.18E−08 
               
               
                 242509_at 
                 C16ORF74 
                 −1.5318238 
                 6.48465026 
                 2.21E−09 
                 6.20E−08 
               
               
                 201939_at 
                 PLK2 
                 −1.5317787 
                 7.43694803 
                 5.43E−09 
                 1.39E−07 
               
               
                 242245_at 
                 SYDE2 
                 −1.5851454 
                 4.93022084 
                 5.57E−09 
                 1.42E−07 
               
               
                 204557_s_at 
                 DZIP1 
                 −1.5326546 
                 5.01217049 
                 5.85E−09 
                 1.48E−07 
               
               
                 204875_s_at 
                 GMDS 
                 −1.7607496 
                 6.33236847 
                 9.81E−09 
                 2.35E−07 
               
               
                 204285_s_at 
                 PMAIP1 
                 −1.7424137 
                 10.9563243 
                 1.15E−08 
                 2.73E−07 
               
               
                 213006_at 
                 CEBPD 
                 −1.9902998 
                 8.08295825 
                 1.47E−08 
                 3.38E−07 
               
               
                 1554830_a_at 
                 STEAP3 
                 −1.6156641 
                 5.65856155 
                 2.19E−08 
                 4.84E−07 
               
               
                 204286_s_at 
                 PMAIP1 
                 −1.7353429 
                 9.45448346 
                 6.05E−08 
                 1.18E−06 
               
               
                 228325_at 
                 KIAA0146 
                 −1.8819676 
                 8.36526925 
                 8.31E−08 
                 1.57E−06 
               
               
                 1569377_at 
                 TMEM67 
                 −1.9524092 
                 4.4888277 
                 1.11E−07 
                 2.04E−06 
               
               
                 242892_at 
                 PER2 
                 −2.1304461 
                 6.97699912 
                 1.72E−07 
                 3.00E−06 
               
               
                 1555847_a_at 
                 LOC84454 
                 −2.1798122 
                 9.88866319 
                 1.88E−07 
                 3.24E−06 
               
               
                   
               
             
          
         
       
     
       Discussion 
     Example 1 
       [0311]    The significant gene-expression changes observed in the human THP-1 cell line due to treatment with branded GA included changes consistent with previous literature (as discussed below), supporting the validity of the chosen model system and current study design for revealing relevant treatment effects. 
         [0312]    For example, expression of the anti-inflammatory gene IL10 was increased at the 6 hour timepoint, consistent with known GA mechanism with regard to monocytes (Kim et al. J. Immunol. Baltim. Md 1950, 2004; Weber et al. Nat. Med. 2007; Mahad et al. Brain J. Neurol. 2006). GA is thought to induce an anti-inflammatory effect, mediated by secretion of IL-4, IL-10, and other anti inflammatory cytokines both in terms of T cells (Th1 to Th2 shift) but also in terms of monocytes, resulting in a shift from monocyte production of IL-12 to anti-inflammatory IL-10. For example, monocytes from mice treated with GA secreted more IL-10 than monocytes from untreated mice (Weber, Nat Med 2007), and monocytes isolated from MS patients treated with GA were shown to produce more IL-10 relative to untreated patients (Kim, J Immunol 2004). In addition, dendritic cells exposed to GA during maturation increased their production of IL-10 (Mahad et al. Brain J. Neurol. 2006). 
         [0313]    Another anti-inflammatory gene, IL1RN (encoding IL-1ra, a protein that inhibits the activities of IL-1a and IL-1b) showed increased expression at all three timepoints. These observations are consistent with work showing that blood levels of soluble IL1-ra increase with GA treatment in patients with MS as well as EAE mice, and that soluble IL1-ra is upregulated by GA treatment in human monocytes either stimulated with LPS or activated by T cell contact (Burger et al, PNAS 2009). 
         [0314]    Branded GA significantly modulated many pathways (Table 5). At 6h, pathways enriched significantly among upregulated genes included broad categories such as immune response and regulation of immune processes, and more specifically cytokine-cytokine receptor interactions. Other significantly enriched pathways included adhesion, and other pathways with broad relevance to the disease process and/or proposed action of GA. Several of these pathways were also significantly enriched among genes modulated by GA in monocytes from RRMS patients (Rosenberg, The Lancet 2005). 
       Example 2 
     Differences in Gene Expression Induced by Probioglat Versus Branded GA 
       [0315]    To identify differences between branded GA and differently manufactured glatiramoids, differential gene expression analysis was performed to compare directly between profiles induced by branded GA and by the purported generic glatiramoid, Probioglat. The standard R LIMMA bioconductor package was utilized to measure differentially expressed probesets across the entire microarray. To compare GA and Probioglat, comparisons were corrected to compare each treatment relative to mannitol control (i.e., [GA vs mannitol] was compared via LIMMA to [Probioglat vs mannitol]). Probesets were filtered by calls of presence on the chip for the relevant samples in the comparison (to be considered present at a given timepoint, a probeset was required to have on average a call of present or marginal across the relevant samples at that timepoint). Probesets were mapped to genes using the annotation available for the U133 Plus 2.0 chip from Affymetrix. FDR adjusted p values reported for genes represent the lowest FDR adjusted p value for present probesets for that gene. 
         [0316]    Many significant differences were observed between GA and Probioiglat (Table 3). As expected based on the more extensive response to GA at 6h, the most differences were observed at the 6h timepoint. 
         [0000]                                                                                                                    TABLE 3                   Dynamic profiles of differentially expressed RNA after stimulation       of THP-1 cells by Probioglat versus Copaxone ®                Stimulation time                6 hours   12 hours   24 hours                Significance   Genes   Probesets   Genes   Probesets   Genes   Probesets           threshold   #   #   #   #   #   #                    Upregulated:   FDR-   115   138   5   5   1   1           adjusted p                   (MMP9)               value &lt; 0.05                                   Nominal   2,597   3,310   1,296   1,560   1,625   1,959           p value &lt; 0.05                               Total   FDR-   136   162   7   7   1   1       modulated   adjusted p                   (MMP9)           (up- and   value &lt; 0.05                               down-   Nominal   4,863   6,208   3,051   3,992   2,843   3,486       regulated):   p value &lt; 0.05               Numbers of genes and probesets modulated by Probioglat relative to GA            
(percent of probesets detected as significantly differentiated between treatments as percentage of the total 47,000 probesets included in the Affymetrix U133 Plus 2.0 chip)
 
         [0317]    See Table 4a for the full list of differentially-expressed probesets at 6h: 138 upregulated, 24 downregulated (126 upregulated, 22 downregulated after presence/absence filtering). These differences included proinflammatory genes that were increased in expression by Probioglat relative to GA, including CCL5, CCL2, MMP9, MMP1, CXCL10, CD14, ICAM1 and BIRC3 (all significant by FDR adjusted p value&lt;0.05) (Table 4a). At the same time, differences were observed in levels of anti-inflammatory genes. Probioglat downregulated anti-inflammatory genes CISH and HSPD1 relative to GA, and upregulated IL10 and PRDM1 relative to branded GA (all significant by FDR adjusted p value&lt;0.05). 
         [0000]    
       
         
               
             
               
               
               
               
               
               
               
               
             
               
             
               
               
               
               
               
               
               
               
             
               
             
               
               
               
               
               
               
               
               
             
               
             
               
               
               
               
               
               
               
               
             
               
             
               
               
               
               
               
               
               
               
             
               
             
               
               
               
               
               
               
               
               
             
           
               
                 TABLE 4a 
               
             
             
               
                   
               
               
                 Human monocyte study: probesets significantly modulated by Copaxone ® relative to Probioglat 
               
               
                 Comparing GA to Probioglat (mannitol-corrected): 
               
             
          
           
               
                 Gene 
                 ID 
                 raw. FC 
                 AveExpr 
                 t 
                 P. Value 
                 adj. P. Val 
                 B 
               
               
                   
               
             
          
           
               
                 Upregulated: 
               
               
                 6 hr: 
               
             
          
           
               
                 MMP9 
                 203936_s_at 
                 −1.2926295 
                 9.63366142 
                 −9.0041791 
                 5.02E−11 
                 2.74E−06 
                 13.793663 
               
               
                 CXCL10 
                 204533_at 
                 −1.4567769 
                 5.93611913 
                 −6.8101441 
                 4.11E−08 
                 0.00056208 
                 8.11662055 
               
               
                 PRDM1 
                 228964_at 
                 −1.3131543 
                 9.26923221 
                 −6.9712916 
                 2.48E−08 
                 0.00056208 
                 8.55501455 
               
               
                 LPXN 
                 216250_s_at 
                 −1.1874257 
                 11.315416 
                 −6.8905168 
                 3.19E−08 
                 0.00056208 
                 8.33560319 
               
               
                 FABP4 
                 203980_at 
                 −1.3897081 
                 8.03922119 
                 −6.4609935 
                 1.24E−07 
                 0.00100306 
                 7.15838496 
               
               
                 — 
                 240076_at 
                 −1.2154985 
                 8.47153306 
                 −6.4502687 
                 1.28E−07 
                 0.00100306 
                 7.12879005 
               
               
                 COL6A1 
                 213428_s_at 
                 −1.1799797 
                 9.17734162 
                 −6.5227006 
                 1.02E−07 
                 0.00100306 
                 7.3284926 
               
               
                 SLC39A8 
                 209267_s_at 
                 −1.1409956 
                 10.4538343 
                 −6.3855772 
                 1.58E−07 
                 0.00107772 
                 6.95009387 
               
               
                 MGC5618 
                 221477_s_at 
                 −1.1617675 
                 10.5471179 
                 −6.2424898 
                 2.48E−07 
                 0.00135843 
                 6.55382496 
               
               
                 SLC39A8 
                 219869_s_at 
                 −1.14866 
                 10.1877186 
                 −6.2694824 
                 2.28E−07 
                 0.00135843 
                 6.62867956 
               
               
                 — 
                 226218_at 
                 −1.2937342 
                 7.33564432 
                 −6.1059571 
                 3.84E−07 
                 0.00140732 
                 6.17456221 
               
               
                 STEAP1 
                 205542_at 
                 −1.198521 
                 7.98610593 
                 −6.0852841 
                 4.10E−07 
                 0.00140732 
                 6.11705174 
               
               
                 CHST11 
                 219634_at 
                 −1.1616563 
                 9.51077621 
                 −6.0764318 
                 4.21E−07 
                 0.00140732 
                 6.09241933 
               
               
                 CD9 
                 201005_at 
                 −1.1480015 
                 10.9097322 
                 −6.0774378 
                 4.20E−07 
                 0.00140732 
                 6.09521866 
               
               
                 TNF5F13B 
                 223502_s_at 
                 −1.137131 
                 10.6086468 
                 −6.1814333 
                 3.02E−07 
                 0.00140732 
                 6.38434731 
               
               
                 LACTB 
                 226354_at 
                 −1.1146026 
                 10.6969136 
                 −6.1724213 
                 3.10E−07 
                 0.00140732 
                 6.35931437 
               
               
                 ARL6IP5 
                 200761_s_at 
                 −1.1108957 
                 11.9357889 
                 −6.0645684 
                 4.38E−07 
                 0.00140732 
                 6.05940234 
               
               
                 NFKBIE 
                 203927_at 
                 −1.1646409 
                 10.0523732 
                 −5.9997498 
                 5.38E−07 
                 0.00157615 
                 5.87889643 
               
               
                 SLIC1 
                 228869_at 
                 −1.1244476 
                 10.0277009 
                 −5.994027 
                 5.48E−07 
                 0.00157615 
                 5.86295139 
               
               
                 MMP1 
                 204475_at 
                 −1.5039262 
                 6.32353561 
                 −5.9312361 
                 6.69E−07 
                 0.00174156 
                 5.68791885 
               
               
                 SOD2 
                 215223_s_at 
                 −1.2035944 
                 9.66361398 
                 −5.9462273 
                 6.38E−07 
                 0.00174156 
                 5.72972041 
               
               
                 NFKBIA 
                 201502_s_at 
                 −1.1701699 
                 11.8415908 
                 −5.9153553 
                 7.04E−07 
                 0.0017486 
                 5.64362855 
               
               
                 ADAMDEC1 
                 206134_at 
                 −1.1861199 
                 8.53747931 
                 −5.7927992 
                 1.04E−06 
                 0.00247065 
                 5.30158178 
               
               
                 MPEG1 
                 226841_at 
                 −1.141713 
                 9.90354597 
                 −5.7187643 
                 1.32E−06 
                 0.00281664 
                 5.09479213 
               
               
                 ANXA2P2 
                 208816_x_at 
                 −1.1086074 
                 11.6486476 
                 −5.7130844 
                 1.34E−06 
                 0.00281664 
                 5.07892372 
               
               
                 — 
                 244434_at 
                 −1.2846909 
                 6.48107186 
                 −5.6742369 
                 1.52E−06 
                 0.00284109 
                 4.97038261 
               
               
                 CCL2 
                 216598_s_at 
                 −1.2516796 
                 11.2421198 
                 −5.6653825 
                 1.56E−06 
                 0.00284109 
                 4.94564092 
               
               
                 ISG20 
                 204698_at 
                 −1.2176821 
                 6.18754674 
                 −5.677111 
                 1.50E−06 
                 0.00284109 
                 4.97841335 
               
               
                 MTSS1 
                 203037_s_at 
                 −1.2132697 
                 11.5042636 
                 −5.6909681 
                 1.44E−06 
                 0.00284109 
                 5.0171321 
               
               
                 IFNGR1 
                 211676_s_at 
                 −1.1076638 
                 12.1480464 
                 −5.6472459 
                 1.65E−06 
                 0.0029127 
                 4.89496045 
               
               
                 — 
                 230795_at 
                 −1.1702144 
                 9.26991641 
                 −5.6333398 
                 1.73E−06 
                 0.00294926 
                 4.85610012 
               
               
                 NFE2L3 
                 236471_at 
                 −1.3257415 
                 5.26403664 
                 −5.6026446 
                 1.90E−06 
                 0.00315306 
                 4.77032024 
               
               
                 CD36 
                 209555_s_at 
                 −1.1414722 
                 9.39991418 
                 −5.5482888 
                 2.26E−06 
                 0.00363742 
                 4.61841752 
               
               
                 CYLD 
                 221903_s_at 
                 −1.1207309 
                 9.54523467 
                 −5.5045621 
                 2.60E−06 
                 0.00406002 
                 4.49622693 
               
               
                 ICAM1 
                 202638_s_at 
                 −1.4084929 
                 6.8285265 
                 −5.4886851 
                 2.73E−06 
                 0.00415135 
                 4.45186392 
               
               
                 KIAA1505 
                 227265_at 
                 −1.1673293 
                 9.93164349 
                 −5.4623712 
                 2.97E−06 
                 0.00423964 
                 4.37834442 
               
               
                 BID 
                 227143_s_at 
                 −1.1112086 
                 11.5740779 
                 −5.471422 
                 2.89E−06 
                 0.00423964 
                 4.40363069 
               
               
                 BID 
                 211725_s_at 
                 −1.1017724 
                 11.8106494 
                 −5.4568423 
                 3.02E−06 
                 0.00423964 
                 4.36289801 
               
               
                 IL10 
                 207433_at 
                 −1.2783883 
                 5.71640286 
                 −5.3801791 
                 3.86E−06 
                 0.00508408 
                 4.14877517 
               
               
                 ANXA2 
                 201590_x_at 
                 −1.1067663 
                 13.1932317 
                 −5.3762172 
                 3.91E−06 
                 0.00508408 
                 4.13771284 
               
               
                 TNFAIP6 
                 206026_s_at 
                 −1.2533604 
                 5.46505459 
                 −5.3471287 
                 4.28E−06 
                 0.00544542 
                 4.0565035 
               
               
                 CD14 
                 201743_at 
                 −1.1688628 
                 9.56313815 
                 −5.3162757 
                 4.72E−06 
                 0.00586803 
                 3.97039297 
               
               
                 ICAM1 
                 202637_s_at 
                 −1.253703 
                 7.7078627 
                 −5.2602772 
                 5.64E−06 
                 0.00674579 
                 3.81417837 
               
               
                 ANXA2 
                 210427_x_at 
                 −1.1021711 
                 13.1600502 
                 −5.2581893 
                 5.68E−06 
                 0.00674579 
                 3.80835622 
               
               
                 SYNJ2 
                 212828_at 
                 −1.1079961 
                 9.8266126 
                 −5.2259269 
                 6.29E−06 
                 0.00731141 
                 3.71841109 
               
               
                 GLIPR1 
                 226142_at 
                 −1.1476518 
                 8.96232728 
                 −5.2116592 
                 6.57E−06 
                 0.00744619 
                 3.67864746 
               
               
                 ECOP 
                 238604_at 
                 −1.1291845 
                 9.93048271 
                 −5.2069623 
                 6.67E−06 
                 0.00744619 
                 3.66555947 
               
               
                 CD40 
                 205153_s_at 
                 −1.1516665 
                 8.96773222 
                 −5.1878467 
                 7.09E−06 
                 0.00775153 
                 3.61230284 
               
               
                 IFIH1 
                 219209_at 
                 −1.1839872 
                 8.4216604 
                 −5.1481808 
                 8.03E−06 
                 0.0086134 
                 3.50184783 
               
               
                 IL4I1 
                 230966_at 
                 −1.2886142 
                 10.7302425 
                 −5.1035983 
                 9.25E−06 
                 0.00953971 
                 3.3777992 
               
               
                 MAFB 
                 218559_s_at 
                 −1.1661498 
                 12.5070822 
                 −5.0783026 
                 1.00E−05 
                 0.01013992 
                 3.30746517 
               
               
                 DAB2 
                 201278_at 
                 −1.1002534 
                 9.40858428 
                 −5.0704754 
                 1.03E−05 
                 0.01020405 
                 3.28570957 
               
               
                 P2RX4 
                 204088_at 
                 −1.11462 
                 10.5804136 
                 −5.0589302 
                 1.06E−05 
                 0.01039288 
                 3.25362692 
               
               
                 MLF1 
                 204784_s_at 
                 −1.1629248 
                 9.99075341 
                 −5.0382007 
                 1.14E−05 
                 0.01089897 
                 3.19604331 
               
               
                 STATH 
                 206835_at 
                 −1.2217631 
                 10.6277925 
                 −4.9970174 
                 1.29E−05 
                 0.01198544 
                 3.08172746 
               
               
                 GIMAP8 
                 235306_at 
                 −1.1769391 
                 7.15724646 
                 −4.9534429 
                 1.48E−05 
                 0.01329267 
                 2.96090645 
               
               
                 TATDN3 
                 235069_at 
                 −1.1552651 
                 9.09091742 
                 −4.9541849 
                 1.48E−05 
                 0.01329267 
                 2.96296263 
               
               
                 SYNJ2 
                 216180_s_at 
                 −1.1540719 
                 8.13588041 
                 −4.929194 
                 1.60E−05 
                 0.01372355 
                 2.89373383 
               
               
                 TREM1 
                 219434_at 
                 −1.1280034 
                 11.1714599 
                 −4.9272524 
                 1.61E−05 
                 0.01372355 
                 2.88835722 
               
               
                 ANXA2 
                 213503_x_at 
                 −1.1003875 
                 13.1627385 
                 −4.8992037 
                 1.76E−05 
                 0.01434614 
                 2.81072248 
               
               
                 G0S2 
                 213524_s_at 
                 −1.1355006 
                 8.75639391 
                 −4.864242 
                 1.96E−05 
                 0.01577044 
                 2.71404776 
               
               
                 IL10RA 
                 204912_at 
                 −1.1199911 
                 10.5172379 
                 −4.8323374 
                 2.17E−05 
                 0.01717268 
                 2.62592271 
               
               
                 BIRC3 
                 210538_s_at 
                 −1.257364 
                 4.57445587 
                 −4.8159991 
                 2.28E−05 
                 0.01765329 
                 2.58083111 
               
               
                 NT5E 
                 203939_at 
                 −1.2383789 
                 8.45460557 
                 −4.8143591 
                 2.29E−05 
                 0.01765329 
                 2.57630644 
               
               
                 CCL5 
                 1555759_a_i 
                 −1.0910656 
                 13.6361191 
                 −4.8032103 
                 2.37E−05 
                 0.01802488 
                 2.54555373 
               
               
                 SRPX2 
                 205499_at 
                 −1.224512 
                 6.16138512 
                 −4.767627 
                 2.65E−05 
                 0.01937153 
                 2.4474847 
               
               
                 ARL6IP5 
                 200760_s_at 
                 −1.1107109 
                 11.7204466 
                 −4.7591181 
                 2.72E−05 
                 0.01959427 
                 2.42405329 
               
               
                 EBI3 
                 219424_at 
                 −1.1775996 
                 7.06372735 
                 −4.7474062 
                 2.82E−05 
                 0.01976554 
                 2.39181393 
               
               
                 CD40 
                 215346_at 
                 −1.1705995 
                 8.77095715 
                 −4.7439006 
                 2.86E−05 
                 0.01976554 
                 2.38216714 
               
               
                 SRA1 
                 224130_s_at 
                 −1.094757 
                 10.8027383 
                 −4.7442703 
                 2.85E−05 
                 0.01976554 
                 2.38318441 
               
               
                 — 
                 238501_at 
                 −1.2105582 
                 5.44953239 
                 −4.73925 
                 2.90E−05 
                 0.01977223 
                 2.36937124 
               
               
                 SLIC1 
                 229045_at 
                 −1.1547886 
                 8.27898536 
                 −4.7357646 
                 2.93E−05 
                 0.01977223 
                 2.35978293 
               
               
                 C5ORF13 
                 238411_x_at 
                 −1.1683694 
                 3.79974787 
                 −4.7297145 
                 2.98E−05 
                 0.01979262 
                 2.34314234 
               
               
                 CARD15 
                 220066_at 
                 −1.1393689 
                 8.86627619 
                 −4.7275995 
                 3.00E−05 
                 0.01979262 
                 2.33732587 
               
               
                 PLEKHO1 
                 218223_s_at 
                 −1.1393641 
                 9.19617144 
                 −4.7232262 
                 3.05E−05 
                 0.01982503 
                 2.32530094 
               
               
                 NFE2L3 
                 204702_s_at 
                 −1.1949945 
                 6.87002251 
                 −4.7001908 
                 3.27E−05 
                 0.02069819 
                 2.26199661 
               
               
                 P2RY5 
                 218589_at 
                 −1.1719902 
                 9.42743243 
                 −4.6980902 
                 3.29E−05 
                 0.02069819 
                 2.25622666 
               
               
                 P5CDBP 
                 209606_at 
                 −1.1833853 
                 8.14303401 
                 −4.6940285 
                 3.34E−05 
                 0.02072301 
                 2.24507189 
               
               
                 PTX3 
                 206157_at 
                 −1.1323376 
                 11.2731131 
                 −4.6853648 
                 3.43E−05 
                 0.0210494 
                 2.22128475 
               
               
                 GHRL 
                 223862_at 
                 −1.184681 
                 7.10722772 
                 −4.6529266 
                 3.79E−05 
                 0.02252098 
                 2.13230051 
               
               
                 SGIP1 
                 223672_at 
                 −1.1713796 
                 8.75400755 
                 −4.6556052 
                 3.76E−05 
                 0.02252098 
                 2.13964377 
               
               
                 RPL13 /// LO           
                 214976_at 
                 −1.1498626 
                 6.91302234 
                 −4.6576183 
                 3.73E−05 
                 0.02252098 
                 2.14516306 
               
               
                 C13ORF31 
                 1553141_at 
                 −1.2240082 
                 8.3027252 
                 −4.6445617 
                 3.89E−05 
                 0.02286455 
                 2.10937474 
               
               
                 — 
                 228573_at 
                 −1.0954948 
                 10.1938031 
                 −4.631833 
                 4.05E−05 
                 0.02353205 
                 2.07450537 
               
               
                 — 
                 213891_s_at 
                 −1.1613505 
                 8.36985954 
                 −4.6072376 
                 4.37E−05 
                 0.02435882 
                 2.00718586 
               
               
                 C9ORF130 
                 227893_at 
                 −1.1466602 
                 7.47771908 
                 −4.6095058 
                 4.34E−05 
                 0.02435882 
                 2.01339098 
               
               
                 VPS33A 
                 204590_x_at 
                 −1.1717826 
                 7.44063872 
                 −4.5964894 
                 4.51E−05 
                 0.0246793 
                 1.97779156 
               
               
                 LACTB 
                 1552486_s_at 
                 −1.1146334 
                 9.43978855 
                 −4.5992016 
                 4.48E−05 
                 0.0246793 
                 1.98520746 
               
               
                 RAB27B 
                 228708_at 
                 −1.2146134 
                 8.64471961 
                 −4.5896791 
                 4.61E−05 
                 0.02495536 
                 1.95917448 
               
               
                 FXYD2 
                 207434_s_at 
                 −1.2391134 
                 6.87935784 
                 −4.5721048 
                 4.87E−05 
                 0.02609092 
                 1.91116075 
               
               
                 SOD2 
                 216841_s_at 
                 −1.1587002 
                 8.29547849 
                 −4.5601654 
                 5.05E−05 
                 0.02658149 
                 1.87856531 
               
               
                 INADL 
                 214493_s_at 
                 −1.1876014 
                 5.13104061 
                 −4.5382854 
                 5.40E−05 
                 0.02787086 
                 1.81888217 
               
               
                 BID 
                 204493_at 
                 −1.0962323 
                 11.1430522 
                 −4.5406927 
                 5.36E−05 
                 0.02787086 
                 1.82544538 
               
               
                 BTG1 
                 240347_at 
                 −1.1577464 
                 6.46143817 
                 −4.5117153 
                 5.86E−05 
                 0.02941834 
                 1.74649575 
               
               
                 CENTA2 
                 219358_s_at 
                 −1.1328376 
                 10.4221094 
                 −4.5125118 
                 5.85E−05 
                 0.02941834 
                 1.74866433 
               
               
                 LOC54103 
                 213142_x_at 
                 −1.1327449 
                 10.7990817 
                 −4.5010122 
                 6.06E−05 
                 0.02985684 
                 1.71736561 
               
               
                 — 
                 232297_at 
                 −1.1396483 
                 8.4593218 
                 −4.4977208 
                 6.12E−05 
                 0.02989176 
                 1.7084108 
               
               
                 THBD 
                 203887_s_at 
                 −1.0860181 
                 12.8670409 
                 −4.4922535 
                 6.23E−05 
                 0.02996581 
                 1.6935397 
               
               
                 KYNU 
                 210663_s_at 
                 −1.1273404 
                 10.5827862 
                 −4.4730592 
                 6.61E−05 
                 0.03124079 
                 1.64136616 
               
               
                 TATDN3 
                 228867_at 
                 −1.0979673 
                 8.53193411 
                 −4.4719767 
                 6.63E−05 
                 0.03124079 
                 1.6384252 
               
               
                 ITGB5 
                 201125_s_at 
                 −1.1305667 
                 9.66682508 
                 −4.4663279 
                 6.74E−05 
                 0.03151651 
                 1.62308225 
               
               
                 HNRPLL 
                 225386_s_at 
                 −1.088481 
                 10.9979975 
                 −4.4607622 
                 6.86E−05 
                 0.03178871 
                 1.60796956 
               
               
                 CRYBB2 
                 206777_s_at 
                 −1.1273748 
                 9.09050704 
                 −4.4486878 
                 7.12E−05 
                 0.03248173 
                 1.57520029 
               
               
                 CD55 
                 1555950_a_i 
                 −1.101176 
                 11.0430169 
                 −4.4455718 
                 7.19E−05 
                 0.03248173 
                 1.56674717 
               
               
                 MPEG1 
                 226818_at 
                 −1.102944 
                 9.97050985 
                 −4.4364675 
                 7.39E−05 
                 0.03312876 
                 1.54205788 
               
               
                 POPDC3 
                 219926_at 
                 −1.2923154 
                 6.73431127 
                 −4.4296067 
                 7.55E−05 
                 0.03333429 
                 1.52346112 
               
               
                 PLAUR 
                 214866_at 
                 −1.1197536 
                 10.1465619 
                 −4.4291541 
                 7.56E−05 
                 0.03333429 
                 1.52223465 
               
               
                 MGLL 
                 239914_at 
                 −1.1755243 
                 5.02263039 
                 −4.4192631 
                 7.79E−05 
                 0.03354952 
                 1.49543825 
               
               
                 EBI2 
                 205419_at 
                 −1.1647466 
                 10.3787766 
                 −4.4209004 
                 7.75E−05 
                 0.03354952 
                 1.49987275 
               
               
                 TP5AB1 /// T 
                 207741_x_at 
                 −1.154419 
                 7.49088254 
                 −4.4208416 
                 7.76E−05 
                 0.03354952 
                 1.49971361 
               
               
                 SLAMF8 
                 219386_s_at 
                 −1.1604525 
                 10.1187042 
                 −4.4123213 
                 7.96E−05 
                 0.03370605 
                 1.47664099 
               
               
                 VSNL1 
                 203797_at 
                 −1.1465556 
                 9.26432896 
                 −4.4080282 
                 8.07E−05 
                 0.03370605 
                 1.46501964 
               
               
                 ICAM2 
                 213620_s_at 
                 −1.129714 
                 7.80787761 
                 −4.4083036 
                 8.06E−05 
                 0.03370605 
                 1.46576519 
               
               
                 KYNU 
                 217388_s_at 
                 −1.1268071 
                 11.2241113 
                 −4.4076297 
                 8.08E−05 
                 0.03370605 
                 1.4639412 
               
               
                 ARHGAP18 
                 225166_at 
                 −1.1854012 
                 7.40195979 
                 −4.3979297 
                 8.32E−05 
                 0.03445978 
                 1.43769541 
               
               
                 MITF 
                 226066_at 
                 −1.1771138 
                 7.94053593 
                 −4.3803753 
                 8.78E−05 
                 0.03578326 
                 1.39023722 
               
               
                 MXD1 
                 226275_at 
                 −1.1272655 
                 8.58697195 
                 −4.3782779 
                 8.84E−05 
                 0.03578326 
                 1.38457024 
               
               
                 — 
                 241389_at 
                 −1.1324551 
                 7.7082004 
                 −4.3740983 
                 8.95E−05 
                 0.03597723 
                 1.37327956 
               
               
                 EGF 
                 206254_at 
                 −1.2273072 
                 5.23328013 
                 −4.3445051 
                 9.80E−05 
                 0.03909529 
                 1.29342221 
               
               
                 MALT1 
                 210017_at 
                 −1.1361187 
                 7.85916694 
                 −4.3417635 
                 9.88E−05 
                 0.03913824 
                 1.28603152 
               
               
                 AKR1C2 
                 211653_x_at 
                 −1.214586 
                 9.21551731 
                 −4.3261491 
                 0.00010361 
                 0.03933789 
                 1.24396403 
               
               
                 LPAAT-THETA 
                 224480_s_at 
                 −1.2033448 
                 8.82402466 
                 −4.3329062 
                 0.00010149 
                 0.03933789 
                 1.26216342 
               
               
                 MFI2 
                 235911_at 
                 −1.1178645 
                 10.2132798 
                 −4.3339031 
                 0.00010118 
                 0.03933789 
                 1.26484915 
               
               
                 ARHGAP18 
                 225171_at 
                 −1.1011604 
                 10.7603262 
                 −4.329986 
                 0.0001024 
                 0.03933789 
                 1.25429744 
               
               
                 TXNL2 
                 209080_x_at 
                 −1.0905642 
                 11.1937357 
                 −4.3267122 
                 0.00010343 
                 0.03933789 
                 1.24548038 
               
               
                 CD55 
                 201926_s_at 
                 −1.0876428 
                 11.0124454 
                 −4.3312016 
                 0.00010202 
                 0.03933789 
                 1.25757168 
               
               
                 ADAM9 
                 202381_at 
                 −1.1288776 
                 10.068453 
                 −4.2795249 
                 0.00011941 
                 0.04461757 
                 1.11860933 
               
               
                 OS8PL11 
                 218304_s_at 
                 −1.1200967 
                 8.80861724 
                 −4.268338 
                 0.00012355 
                 0.04461757 
                 1.08859065 
               
               
                 C5ORF32 
                 224797_at 
                 −1.1088424 
                 9.60174121 
                 −4.2676443 
                 0.00012381 
                 0.04461757 
                 1.08672987 
               
               
                 CD300A 
                 209933_s_at 
                 −1.0919093 
                 11.068246 
                 −4.2779818 
                 0.00011998 
                 0.04461757 
                 1.11446708 
               
               
                 ATP2C1 
                 237278_x_at 
                 −1.1252002 
                 4.516837 
                 −4.2604681 
                 0.00012654 
                 0.04474124 
                 1.06748681 
               
               
                 TGM5 
                 207911_s_at 
                 −1.0985729 
                 10.9973837 
                 −4.255458 
                 0.00012848 
                 0.04474124 
                 1.05405768 
               
               
                 CAST 
                 208908_s_at 
                 −1.0958388 
                 10.4613552 
                 −4.2557149 
                 0.00012838 
                 0.04474124 
                 1.05474617 
               
               
                 TNFRSF9 
                 207536_s_at 
                 −1.1669411 
                 6.64800587 
                 −4.2459826 
                 0.00013222 
                 0.04518347 
                 1.02867283 
               
               
                 HMGB2 
                 243368_at 
                 −1.1602025 
                 4.88716386 
                 −4.2463169 
                 0.00013209 
                 0.04518347 
                 1.02956814 
               
               
                 TNFAIP3 
                 202644_s_at 
                 −1.1253187 
                 10.6490533 
                 −4.2484635 
                 0.00013123 
                 0.04518347 
                 1.03531746 
               
               
                 C1ORF21 
                 223125_s_at 
                 −1.1101543 
                 11.0658204 
                 −4.2399019 
                 0.00013469 
                 0.04573895 
                 1.01239127 
               
               
                 — 
                 212387_at 
                 −1.148179 
                 7.86470579 
                 −4.2245512 
                 0.0001411 
                 0.04762227 
                 0.97132047 
               
             
          
           
               
                 12 hr: 
               
             
          
           
               
                 PRDM1 
                 228964_at 
                 −1.3131187 
                 7.67111264 
                 −8.6246024 
                 1.41E−10 
                 7.72E−06 
                 11.3048141 
               
               
                 RCSD1 
                 239328_at 
                 −1.2917804 
                 9.91539671 
                 −6.452108 
                 1.22E−07 
                 0.0033307 
                 6.31495199 
               
               
                 BTG1 
                 240347_at 
                 −1.2562187 
                 6.63516956 
                 −5.7047112 
                 1.33E−06 
                 0.02422499 
                 4.46209908 
               
               
                 FBXO45 
                 225099_at 
                 1.13350791 
                 9.69247626 
                 5.51958363 
                 2.40E−06 
                 0.03282196 
                 3.99779146 
               
               
                 ZNF566 
                 240239_at 
                 1.20902406 
                 6.20206745 
                 5.35216774 
                 4.09E−06 
                 0.04477351 
                 3.57707114 
               
             
          
           
               
                 24 hr: 
               
             
          
           
               
                 MMP9 
                 203936_s_at 
                 −1.2587837 
                 8.76550502 
                 −6.6308842 
                 7.89E−08 
                 0.00431641 
                 6.0372842 
               
             
          
           
               
                 Downregulated: 
               
               
                 6 hr: 
               
             
          
           
               
                 LOC648342 
                 1569392_at 
                 1.25828385 
                 6.46339373 
                 5.71764607 
                 1.32E−06 
                 0.00281664 
                 5.09166798 
               
               
                 BTBD14A 
                 243431_at 
                 1.31196093 
                 8.69387594 
                 5.37680876 
                 3.90E−06 
                 0.00508408 
                 4.13936456 
               
               
                 SERPINB2 
                 204614_at 
                 1.25751853 
                 10.7388922 
                 5.14040426 
                 8.23E−06 
                 0.00865761 
                 3.48020227 
               
               
                 MYB 
                 204798_at 
                 1.09897729 
                 13.1513017 
                 5.00361266 
                 1.27E−05 
                 0.01194194 
                 3.10002645 
               
               
                 STT3B 
                 238303_at 
                 1.2645975 
                 6.00460112 
                 4.9254338 
                 1.62E−05 
                 0.01372355 
                 2.88332163 
               
               
                 HSPD1 
                 241716_at 
                 1.30689927 
                 6.02121553 
                 4.9223221 
                 1.64E−05 
                 0.01372355 
                 2.87470616 
               
               
                 ACTN4 
                 232058_at 
                 1.19228742 
                 8.60657642 
                 4.91815847 
                 1.66E−05 
                 0.01372355 
                 2.86317939 
               
               
                 FAM62A 
                 244234_at 
                 1.14840119 
                 7.29749849 
                 4.78192868 
                 2.54E−05 
                 0.01899888 
                 2.48688527 
               
               
                 HIC2 
                 1559600_at 
                 1.17980654 
                 8.38342055 
                 4.76703429 
                 2.66E−05 
                 0.01937153 
                 2.4458524 
               
               
                 OXCT2 
                 235275_at 
                 1.16642629 
                 12.3300201 
                 4.71420617 
                 3.13E−05 
                 0.02014951 
                 2.30050545 
               
               
                 — 
                 228907_at 
                 1.17599277 
                 8.21884465 
                 4.6120071 
                 4.30E−05 
                 0.02435882 
                 2.02023432 
               
               
                 GAPDHS 
                 222280_at 
                 1.1646993 
                 7.71035699 
                 4.60723903 
                 4.37E−05 
                 0.02435882 
                 2.00718978 
               
               
                 SPFH1 
                 202441_at 
                 1.12657525 
                 11.0883546 
                 4.55979394 
                 5.06E−05 
                 0.02658149 
                 1.87755147 
               
               
                 NAPB 
                 1570441_at 
                 1.20267749 
                 5.92073389 
                 4.52611168 
                 5.61E−05 
                 0.02866712 
                 1.78570418 
               
               
                 HNRPD 
                 213359_at 
                 1.16888386 
                 9.72519123 
                 4.50340998 
                 6.02E−05 
                 0.02985684 
                 1.72389004 
               
               
                 CISH 
                 223377_x_at 
                 1.09133621 
                 9.01105134 
                 4.49116936 
                 6.25E−05 
                 0.02996581 
                 1.69059129 
               
               
                 SFRS14 
                 64371_at 
                 1.12400512 
                 8.1962891 
                 4.44643142 
                 7.17E−05 
                 0.03248173 
                 1.5690791 
               
               
                 C14ORF10 
                 239188_at 
                 1.16314645 
                 6.54891766 
                 4.38855767 
                 8.56E−05 
                 0.03519643 
                 1.4123519 
               
               
                 — 
                 232903_at 
                 1.21778341 
                 6.93050721 
                 4.29620676 
                 0.0001135 
                 0.04279881 
                 1.16341547 
               
               
                 HDAC4 
                 232225_at 
                 1.14445571 
                 7.77327378 
                 4.27489999 
                 0.00012111 
                 0.04461757 
                 1.10619611 
               
               
                 CLK1 
                 214683_s_at 
                 1.160507 
                 9.27028645 
                 4.268656 
                 0.00012343 
                 0.04461757 
                 1.08944366 
               
               
                 CRLF3 
                 235803_at 
                 1.19940674 
                 9.07113133 
                 4.2670238 
                 0.00012404 
                 0.04461757 
                 1.08506571 
               
               
                 ZNF250 
                 241738_at 
                 1.11389598 
                 4.2390353 
                 4.26401964 
                 0.00012518 
                 0.04473242 
                 1.07700912 
               
               
                 WDFY1 
                 234157_at 
                 1.20859908 
                 6.39798409 
                 4.25895039 
                 0.00012712 
                 0.04474124 
                 1.06341818 
               
             
          
           
               
                 12 hr: 
               
             
          
           
               
                 FBXO45 
                 225099_at 
                 1.13350791 
                 9.69247626 
                 5.51958363 
                 2.40E−06 
                 0.03282196 
                 3.99779146 
               
               
                 ZNF566 
                 240239_at 
                 1.20902406 
                 6.20206745 
                 5.35216774 
                 4.09E−06 
                 0.04477351 
                 3.57707114 
               
               
                   
               
               
                             indicates data missing or illegible when filed 
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
             
               
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
               
             
           
               
                 TABLE 4b 
               
             
             
               
                   
               
               
                 Probioglat expression values for key genes compared to the 
               
               
                 range set by observed expression values under Copaxone ® treatment 
               
             
          
           
               
                   
                   
                 Copaxone 
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 Expression Value 
                   
                   
                   
                   
                   
                   
               
             
          
           
               
                   
                   
                 Range 
                 Probioglat Expression Values 
               
             
          
           
               
                   
                   
                 Maxi- 
                 Mini- 
                 Sample 
                 Sample 
                 Sample 
                 Sample 
                 Sample 
                 Sample 
               
               
                 Probeset 
                 Gene 
                 mum 
                 mum 
                 1 
                 2 
                 3 
                 4 
                 5 
                 6 
               
               
                   
               
             
          
           
               
                 203936_s_at 
                 MMP9 
                 9.97 
                 9.53 
                 
                   10.14 
                 
                 
                   10.05 
                 
                 
                   10.12 
                 
                 
                   10.14 
                 
                 
                   10.04 
                 
                 
                   10.04 
                 
               
               
                 201743_at 
                 CD14 
                 9.69 
                 9.32 
                 
                   9.75 
                 
                 
                   9.75 
                 
                 9.67 
                 
                   9.79 
                 
                 
                   9.71 
                 
                 
                   9.86 
                 
               
               
                 202637_s_at 
                 ICAM1 
                 8.06 
                 7.44 
                 
                   8.14 
                 
                 7.96 
                 
                   8.26 
                 
                 7.84 
                 
                   8.18 
                 
                 7.92 
               
               
                 202638_s_at 
                 ICAM1 
                 7.30 
                 6.51 
                 
                   7.67 
                 
                 
                   7.54 
                 
                 
                   7.45 
                 
                 
                   7.32 
                 
                 7.19 
                 6.94 
               
               
                 223961_s_at 
                 CISH 
                 7.69 
                 7.24 
                 7.31 
                 
                   7.20 
                 
                 7.41 
                 7.37 
                 7.62 
                 
                   7.23 
                 
               
               
                 223377_x_at 
                 CISH 
                 9.11 
                 8.86 
                 
                   8.81 
                 
                 
                   8.81 
                 
                 
                   8.82 
                 
                 
                   8.85 
                 
                 
                   8.84 
                 
                 8.88 
               
               
                   
               
               
                   Red  text indicates that the expression value for this Probioglat treated sample is outside of the observed range of all Copaxone samples. 
               
             
          
         
       
     
       Discussion 
     Example 2 
     Pro-Inflammatory Genes 
       [0318]    Gene-level differentiation analysis identifies specific pro-inflammatory markers when comparing Probioglat to Copaxone®. Upon comparison of GA with Probioglat, significant gene-expression differences were seen (Table 3). Only one batch of Probioglat was available to compare to the four batches of GA, prohibiting the possibility to study batch-to-batch variability. However, the range of variation defined by the four GA batches represents a range of variation that has been demonstrated to be safe and effective by Copaxone®&#39;s clinical trials. The fact that any single batch of Probioglat results in values outside of that range (as illustrated in Table 4b and  FIG. 44 ), coupled with lack of PK or PD markers to determine equivalence of the two glatiramoids, warrants further investigation. 
         [0319]    The consistent confirmatory results obtained by single-probeset, pathway and independent qRT-PCR analysis are particularly robust, given the stringent statistical framework employed. It should be noted that fewer genes were significantly modulated by GA relative to Probioglat than by GA relative to mannitol, an observation expected given the intended mimicry of structure between the compounds. Indeed many genes were modulated in the same direction by both GA and Probioglat versus control, but to differing extents (the cases for many genes discussed below, except where noted). It is striking that differences were observed between branded GA and the designed purported generic, Probioglat. Two drugs cannot be said to have identical effects if significant differences are manifest. Importantly, the significant differences in gene expression observed between Probioglat and Copaxone® were seen in genes tied to highly relevant disease pathoetiology and known GA mode of action (MOA). Bioinformatic analysis of differentially expressed genes (by FDR corrected p value) following Probioglat versus Copaxone® stimulation of human monocytes at 6 hours identified a number of genes tied to important immune system functions, in particular inflammation: CCL5, CCL2, MMP9, MMP1, CXCL10, CD14, ICAM1 and BIRC3. Several of these genes have been reported in the literature as modulated by GA treatment in patients.
       1. CCL5 (RANTES) is a key chemokine thought to attract inflammatory immune cells to the CNS, and was significantly upregulated in Probioglat treatment relative to Copaxone® treatment at 6 hours (FDR adjusted p value 0.018, FC 1.09 in gene expression analysis; p value 4e-5, FC 1.12 in qRT-PCR confirmation). Indeed, an antibody blocking CCL5 was shown to reduce disease metrics including immune infiltration into the CNS in a viral MS model (Glass et al, Immunol Res, 2004; Chirstensen et al. Mult. Scler. J. 2013). Expression of the CCL5 receptor, CCR5, on GA-reactive T cells from MS patients was shown to be downregulated by chronic (1 year) GA treatment (Allie et al, Arch Neurol 2005; Kouwenhoven et al. J. Neuroimmunol. 2002). This gene was tested and confirmed to be upregulated with Probioglat treatment relative to GA treatment in primary human monocytes (p&lt;0.029, FC 1.53).   2. Expression of MMP9 (Matrix Metalloproteinase 9) was significantly higher with Probioglat versus GA stimulation at 6h (FDR-adjusted p-value 2.8e-6, FC 1.29 in gene-expression analysis,  FIG. 41 a   ; p-value 0.02, FC 1.24 in qRT-PCR confirmation), and at 24h (FDR-adjusted p-value 0.004, FC 1.25). The MMP9 gene was also upregulated with Probioglat relative to GA treatment in primary human monocytes (p&lt;0.009, FC 1.4). This protein is reported to increase access of immune cells to the CNS by contributing to disruption of the blood brain barrier (BBB) (Rosenberg et al, The Lancet 2005), and high levels of MMP9 have been associated with Multiple Sclerosis (Christensen et al, Mult. Scler 2013; Milward et al., J. Neuroimmunol. 2008; Knop et al, Neurology 2013; Parks et al, Nat. Rev. Immunol 2004). MMP9 was upregulated with Probioglat relative to Copaxone® stimulation at 6 hours (FDR adjusted p value 2.8e-6 in gene expression analysis; p value 0.02 in qRT-PCR confirmation). Expression levels of MMP9 at both the mRNA and protein level were increased in immature dendritic cells from MS patients relative to healthy controls (Kouwenhoven et al, J Neuroimmunol 2002). Elevated MMP9 levels were reported in patients with gadolinium-enhancing lesions relative to patients without (Waubant et al, Dis Markers 2006; Antonelli et al, Autoimmun. Rev. 2014), and MMP9 has been proposed as a biomarker for both MS diagnosis and progression (Milward et al, J Neuroimmunol 2008; Peperzak et al, J. Immunol. Batim. Md 1950, 2013). GA has been reported to inhibit MMP9 expression in healthy human peripheral blood mononuclear cells (PBMC) (Knop et al, Neurology 2013 (Meeting Abstract); Adrem and Ulevitch, Nature 2000). Increased expression of MMP9 for Probioglat relative to Copaxone® at multiple timepoints ( FIG. 7 ).   3. The level of MMP1, another matrix metalloproteinase gene, was increased after Probioglat stimulation compared to Copaxone® at 6 hours (FDR adjusted p value 0.002, FC 1.50 in gene expression analysis; p value 0.02, FC 1.25 in qRT-PCR confirmation). Matrix metalloproteinases are known to cleave pro-inflammatory cytokines and chemokines to regulate inflammation (Parks et al, Nat Rev Immunol, 2004; Baumann et al, J. Exp. Med. 2010). Levels of MMP1 mRNA, as well as secreted MMP1, were observed to be higher in immature dendritic cells from MS patients relative to healthy controls (Kouwenhoven et al, J Neuroimmunol 2002; Parks et al, Nat Rev Immunol, 2004).   4. Expression of the chemokine CXCL10 was increased by Probioglat stimulation compared to Copaxone® at 6 hours (FDR adjusted p value 0.0006, FC 1.46 in gene expression analysis; p value 0.0029, FC 2.28 in qRT-PCR confirmation). This finding was confirmed by qRT-PCR in primary human monocytes, where CXCL10 was upregulated by Probioglat relative to Copaxone treatment with p value&lt;0.02 and fold change of 2.1. CXCL10 level in peripheral fluids was previously shown as associated with host immune response, particularly with regard to Th-1 cells (Antonelli et al, Autoimm. Rev., 2014; Natarajan et al, J. Nueroimmunol. 2013). CXCL10 is involved in recruiting CD8+ and Th1 CD4+ effector T cells to sites of inflammation (Peperzak et al, J Immunol, 2013; Hedegaard et al, PLoS ONE 2011). A study using monocytes from RRMS patients demonstrated CXCL10 to be increased by GA therapy within the first two months of treatment (Thamilarasan et al, J Neuroinflammation 2013; Rosenberg, The Lancet 2005).   5. CD14 is a marker of monocyte activation known to enhance inflammatory responses. CD14 was upregulated in human monocytes stimulated by Probioglat versus Copaxone 6 hours (FDR adjusted p value 0.006, FC 1.17; qRT-PCR not tested;  FIG. 41 b   ). CD14 was not modulated by GA treatment versus mannitol control. This marker of monocyte activation enhances inflammatory responses (Mycko et al, Ann. Neurol. 1998). In complex with LPS binding protein (LBP), CD14 interacts with LPS and helps to present it to toll-like receptor 4 (TLR4), activating downstream expression of inflammatory genes via NF-kB (Park et al, Exp Mol Med, 2013). CD14 has also been shown to be a coreceptor for other TLRs, and was demonstrated to be required for induction of proinflammatory cytokines via TLR7 and TLR9 in mouse and human cells in vitro (Baumann et al, J Exp Med, 2010; Bullard et al, J. Immunol. 2007). Increased expression of CD14 for Probioglat was determined relative to Copaxone® ( FIG. 8 ).   6. CARD15 (NOD2), another gene upregulated by Probioglat versus Copaxone at 6 hours (FDR adjusted p value 0.02, FC 1.14; qRT-PCR not tested), is also a key player in the immune response to LPS, participating in activation of NF-kB. Activation of NOD2 by peptidoglycan has been shown to induce CNS demyelination in rats (Natarajan et al, 2013; Sellner et al, Clin. Exp. Immunol. 2013). In addition, a SNP in NOD2 was shown to affect the responses of Th2 and Th17 cells to myelin basic protein (MBP) in MS (Hedegaard et al, 2011; Bertrand et al, Immunity 2009).   7. BIRC3 expression was increased by Probioglat relative to Copaxone® at 6 hours (FDR adjusted p value 0.018, FC 1.26; qRT-PCR not tested). This gene codes for an Inhibitor of Apoptosis Protein (IAP-1), which in addition to its role in cell survival plays a role in both innate immunity (Bertrand, 2009; Kearny et al, J. Biol. Chem. 2013) and inflammation (Labbe et al, 2011; Ashburner et al, Nat. Genet. 2000), and has been suggested to have an immunomodulatory effect in autoimmune demyelination (Hebb et al, 2008; Kanehisa et al, Nucleic Acis Res. 2000). IAPs including IAP-1 are required for production of pro-inflammatory cytokines via several different pathways, including TLR4 activation (Tseng et al, 2010; Zanin-Zhorov et al, J. Clin. Invest. 2006) and NOD2 activation by TNFα (Kearney et al, JBC, 2012; Qin et al, Proc. Natl. Acad. Sci. 2012).
           CCL2 (MCP-1) is another pro-inflammatory cytokine that was also expressed significantly more highly with Probioglat treatment relative to Copaxone at 6 hours (FDR adjusted p value 0.003, FC 1.25; qRT-PCR not tested). CCL2 expression was decreased by GA treatment relative to mannitol control, and decreased to a lesser extent by Probioglat relative to mannitol control. CCL2 is thought to recruit inflammatory cells into the CNS in EAE and in MS (Mahad et al, 2006; Waubant, Dis. Markers 2006). This gene was also confirmed to be upregulated with Probioglat relative to GA treatment in primary human monocytes (p&lt;0.009, FC 1.24).   
           8. ICAM1 expression was increased by Probioglat relative to Copaxone® at 6 hours (FDR adjusted p value 0.004, FC 1.41; qRT-PCR not tested;  FIG. 41 c   ). ICAM1 is an adhesion molecule that plays a key role in inflammatory processes by promoting leukocyte adhesion to the endothelium of the vascular wall, and is known to have an important role in inflammatory cell infiltration into the CNS in both EAE and MS (Mycko et al, Ann. Neurol. 1994; Labbe et al, Immunity 2011). In mice null for ICAM1, T cells produced significantly less IFNγ and showed much less infiltration into the spinal cord (Bullard et al, J Immunol, 2007; Hebb et al, Mult. Scler. Houndmills Basingstoke Engl. 2008). In PBMC from RRMS patients, ICAM1 levels were higher versus healthy controls, and chronic treatment with GA affected surface ICAM1 levels in multiple immune cell types (Sellner et al, Clin Exp Immunol 2013; Tseng et al, Nat. Immunol. 2010). Increased expression of ICAM1 for Probioglat was determined compared to Copaxone® stimulation ( FIG. 11 ).       
 
       Anti-Inflammatory Genes 
       [0329]    As discussed herein, a number of pro-inflammatory genes and pathways were shown to be significantly upregulated by Probioglat as compared to Copaxone®. At the same time, several anti-inflammatory genes were downregulated by Probioglat stimulation in comparison with Copaxone® at 6 hours.
       1. CISH, also known as SOCS (Suppressor of Cytokine Signaling), was expressed at lower level with Probioglat relative to Copaxone® at 6 hours (FDR adjusted p value 0.03, FC −1.09;  FIG. 41 d   ). A closely related protein, SOCS3, has been shown in myeloid cells to protect from EAE, the mouse model of MS, via deactivating neuroinflammatory responses (Qin et al, PNAS 2012; Bakshi et al, Expert Opin. THer. Targets 2013). Both present probesets for this gene were affected in the same direction ( FIG. 12 ). A SNP in SOCS1, another family member, has been identified as a risk factor for MS (Towfic et al, PLoS ONE 2014).   2. HSPD1, also known as HSP-60 (heat shock 60 kDa protein 1), was downregulated in Probioglat relative to Copaxone® at 6 hours (FDR adjusted p value 0.01, FC −1.31). Zanin-Zhorov et al (2006) showed that HSP60 as well as synthetic peptide derived from HSP60 act as co-stimulators of Tregs through the TLR2 pathway. Tregs are immune regulatory cells that inhibit lympho-proliferation and IFNG and TNF secretion by pro-inflammatory T cells. Zanin-Zhorov et al concluded that HSP60 can downregulate adaptive immune responses by upregulating Tregs. Thus, downregulation of HSPD1 may result in less inhibition of immune response by Probioglat compared to Copaxone®.       
 
         [0332]    It should be noted, however, the anti-inflammatory cytokine IL10, known to be relevant to the GA mechanism of action, was also expressed at a higher level subsequent Probioglat relative to Copaxone treatment at 6 hours (FDR adjusted p value 0.005, FC 1.28). The same observation holds for another gene at 6 and 12 hours, PRDM1 (Blimp1) (FDR adjusted p value 0.0006 and 7.7e-6, and FC 1.31 and 1.31 respectively), that when deleted results in inflammatory pathology (Chiang et al, PNAS 2013; Johnson et al, Biostat. Oxf. Engl. 2007). Blimp1 is a target of FOXP3 and is needed for production of IL10 by Tregs; its expression can also be induced by IL2 and proinflammatory cytokines in Tregs (Cretney et al, Nat Immunol. 2011; Leek et al, Surrogate Variabel Analysis 2013). However, it is not clear what these observations would imply for APCs such as monocytes. It is possible that higher Blimp1 could be an attempted protective response to a higher inflammatory milieu. A statidtically significant difference in such a mechanistically relevant gene—in either direction—between two therapeutics intended to be identical presents motivation for further study. 
       Example 3 
     Pathway Enrichment Analysis 
       [0333]    Upregulated and downregulated genes were analyzed separately for pathway enrichment, using DAVID (Huang et al, Nucleic Acids Res 2009). 
         [0334]    Pathway enrichment results were visualized using volcano plots, plotting −log p values versus enrichment scores. For GA MOA, to obtain top-gene lists of appropriate size (tens-hundreds) for use with DAVID, an absolute-value-fold-change cutoff of 1.5 and p-value cutoff of 1e-5 were utilized to obtain gene lists for pathway enrichment at 6h. For comparisons between branded GA and Probioglat, upregulated or downregulated genes with FDR-adjusted p values&lt;0.05 were used for pathway enrichment. 
         [0335]    DAVID runs were conducted May 21, 2014. Please note that the GO databases are updated daily (as noted on the GO site:www.geneontology.org/GO.downloads.ontology.shtml) and therefore performing the same enrichments on the same genesets may yield slightly varying results depending on the run date, as illustrated by the differences in Table 6 (results from runs on differing dates using broader or more restrictive subsets of GO). Thus, the pathway p values may change slightly between runs conducted at different times; the overall picture of enriched pathways, however, is expected to remain consistent. Three time points were tested to identify the fold change and p value filters were used to obtain top gene lists of appropriate size (i.e. tens to hundreds) for use with DAVID (Table 5). 
         [0336]    No pathways were enriched significantly among downregulated genes, however 106 pathways were enriched significantly (Benjamini corrected p value&lt;0.05) among genes upregulated by Probioglat relative to GA, including immune system process (GO:0002376), immune system process (GO:0002376) and immune response (GO:0006955) pathways (Benjamini-corrected p-values 1.5e-5 and 3.3e-4, respectively), and many other immune system related pathways, such as regulation of lymphocyte mediated immunity (GO:0002706, Benjamini-corrected p-value 0.007) and B cell proliferation (GO:0042100 Benjamini-corrected p-value 0.049) ( FIG. 10  and Table 6). Multiple significantly enriched pathways were relevant to inflammation, including response to lipopolysaccharide (LPS) (GO:0032496;  FIG. 9 ), regulation of inflammatory response (GO:0050727), regulation of tumor necrosis factor production (GO:0032680), and NOD-like receptor signaling (hsa04621) (Benjamini-corrected p-values of 8.7e-4, 0.015, 0.028, and 0.027, respectively). No pathways were enriched significantly among genes downregulated by Probioglat versus GA. 
         [0337]    Genes analyzed for pathway enrichment (Tables 5 and 6), using DAVID (conducted May 21, 2014). Performing the same enrichments on the same genesets may yield slightly varying results depending on the run date (GO databases are updated daily: www.geneontology.org/GO.downloads.ontology.shtml). 
         [0000]    
       
         
               
             
               
               
               
               
               
             
               
             
               
               
               
               
               
             
               
             
               
               
               
               
               
             
               
               
             
               
             
               
               
             
               
             
               
               
             
               
               
               
             
               
               
             
               
               
               
             
               
               
             
               
               
               
             
           
               
                 TABLE 5 
               
               
                   
               
               
                 Human monocyte study: pathways significantly enriched among 
               
               
                 genes significantly upregulated by Copaxone ® relative to mannitol at 
               
               
                 6 hours. 
               
               
                 Pathways significantly enriched among top genes modulated by GA relative to mannitol control at 6 hours: 
               
               
                 Top genes are defined by cutoffs of |FC|&gt;1.5 and p-value&lt;1e−5 to obtain lists of appropriate size for use with DAVID. 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                   
                 Term 
                 P value 
                 Fold Enrichment 
                 Benjamini 
               
               
                   
                   
               
             
          
           
               
                 Enriched among top downregulated genes: 
               
             
          
           
               
                   
                 GO: 0007275~multicellular 
                 6.94E−06 
                 2.168367347 
                 0.00270611 
               
               
                   
                 organismal 
               
               
                   
                 development 
               
               
                   
                 GO: 0048731~system 
                 5.04E−06 
                 2.396166134 
                 0.00294797 
               
               
                   
                 development 
               
               
                   
                 GO: 0048513~organ 
                 2.61E−06 
                 2.760084926 
                 0.00305609 
               
               
                   
                 development 
               
               
                   
                 GO: 0048856~anatomical 
                 3.69E−05 
                 2.164502165 
                 0.00861537 
               
               
                   
                 structure development 
               
               
                   
                 GO: 0030154~cell 
                 4.49E−05 
                 2.555555556 
                 0.00871888 
               
               
                   
                 differentiation 
               
               
                   
                 GO: 0032502~developmental 
                 3.28E−05 
                 1.984126984 
                 0.00955745 
               
               
                   
                 process 
               
               
                   
                 GO: 0003006~reproductive 
                 8.34E−05 
                 6.25 
                 0.01385786 
               
               
                   
                 developmental 
               
               
                   
                 process 
               
               
                   
                 GO: 0048869~cellular 
                 0.00010797 
                 2.410901468 
                 0.0156803 
               
               
                   
                 developmental process 
               
               
                   
                 GO: 0009653~anatomical 
                 0.00030745 
                 2.643171806 
                 0.03921862 
               
               
                   
                 structure morphogenesis 
               
             
          
           
               
                 Enriched among top upregulated genes: 
               
             
          
           
               
                   
                 GO: 0005886~plasma 
                 1.02E−13 
                 2.419799407 
                 2.18E−17 
               
               
                   
                 membrane 
               
               
                   
                 GO: 0031226~intrinsic to 
                 1.09E−11 
                 3.267558528 
                 7.78E−10 
               
               
                   
                 plasma membrane 
               
               
                   
                 GO: 0016020~membrane 
                 8.59E−12 
                 1.538151311 
                 9.23E−10 
               
               
                   
                 GO: 0005887~integral to 
                 2.42E−11 
                 3.249703017 
                 1.04E−09 
               
               
                   
                 plasma membrane 
               
               
                   
                 GO: 0044459~plasma 
                 1.97E−11 
                 2.403721216 
                 1.06E−09 
               
               
                   
                 membrane part 
               
               
                   
                 GO: 0005576~extracellular 
                 1.37E−10 
                 2.823873071 
                 4.90E−Q9 
               
               
                   
                 region 
               
               
                   
                 GO: 0031224~intrinsic to 
                 4.97E−10 
                 1.683683794 
                 1.53E−08 
               
               
                   
                 membrane 
               
               
                   
                 GO: 0004871~signal 
                 1.04E−10 
                 2.537224567 
                 2.51E−08 
               
               
                   
                 transducer activity 
               
               
                   
                 GO: 0060089~molecular 
                 1.04E−10 
                 2.537224567 
                 2.51E−08 
               
               
                   
                 transducer activity 
               
               
                   
                 GO: 0004872~receptor 
                 6.20E−11 
                 2.976306146 
                 2.99E−08 
               
               
                   
                 activity 
               
               
                   
                 GO: 0044425~membrane 
                 1.40E−09 
                 1.538980298 
                 3.75E−08 
               
               
                   
                 part 
               
               
                   
                 GO: 0016021~integral to 
                 1.98E−09 
                 1.675513671 
                 4.73E−08 
               
               
                   
                 membrane 
               
               
                   
                 GO: 0044421~extracellular 
                 3.24E−09 
                 3.610050499 
                 6.97E−08 
               
               
                   
                 region part 
               
               
                   
                 GO: 0004888~transmembrane 
                 2.35E−09 
                 3.768030976 
                 3.78E−07 
               
               
                   
                 receptor activity 
               
               
                   
                 GO: 0006955~immune 
                 9.81E−10 
                 3.570488309 
                 6.34E−07 
               
               
                   
                 response 
               
               
                   
                 GO: 0009611~response 
                 3.29E−10 
                 4.097150568 
                 6.39E−07 
               
               
                   
                 to wounding 
               
               
                   
                 GO: 0009605~response 
                 7.26E−10 
                 3.127282815 
                 7.04E−07 
               
               
                   
                 to external stimulus 
               
               
                   
                 GO: 0002376~immune 
                 1.92E−09 
                 2.852452609 
                 9.30E−07 
               
               
                   
                 system process 
               
               
                   
                 GO: 0050896~response 
                 2.41E−09 
                 1.852190811 
                 9.36E−07 
               
               
                   
                 to stimulus 
               
               
                   
                 GO: 00322501~multicellular 
                 7.40E−09 
                 1.769727444 
                 2.39E−06 
               
               
                   
                 organismal process 
               
               
                   
                 GO: 0050793~regulation 
                 3.28E−08 
                 3.160728606 
                 9.08E−06 
               
               
                   
                 of developmental 
               
               
                   
                 process 
               
               
                   
                 GO: 0009897~external 
                 5.99E−07 
                 6.496675192 
                 1.17E−05 
               
               
                   
                 side of plasma 
               
               
                   
                 membrane 
               
               
                   
                 GO: 0051239~regulation 
                 7.17E−08 
                 2.791593852 
                 1.54E−05 
               
               
                   
                 of multicellular 
               
               
                   
                 organismal process 
               
               
                   
                 GO: 0006952~defense 
                 6.90E−08 
                 3.417964583 
                 1.67E−05 
               
               
                   
                 response 
               
               
                   
                 GO: 0006954~inflammatory 
                 8.72E−08 
                 4.475172847 
                 1.69E−05 
               
               
                   
                 response 
               
               
                   
                 GO: 0031012~extracellular 
                 1.51E−06 
                 5.017117426 
                 2.70E−05 
               
               
                   
                 matrix 
               
               
                   
                 GO: 0048583~regulation 
                 1.68E−07 
                 3.612684989 
                 2.96E−05 
               
               
                   
                 of response to stimulus 
               
               
                   
                 GO: 0005578~proteinaceous 
                 2.00E−06 
                 5.309782609 
                 3.07E−05 
               
               
                   
                 extracellular matrix 
               
               
                   
                 GO: 0009986~cell surface 
                 1.88E−06 
                 4.06706753 
                 3.10E−05 
               
               
                   
                 GO: 0002682~regulation 
                 3.21E−07 
                 3.763213531 
                 5.19E−05 
               
               
                   
                 of immune system 
               
               
                   
                 process 
               
               
                   
                 GO: 0005615~extracellular 
                 6.96E−06 
                 3.371290545 
                 9.98E−05 
               
               
                   
                 space 
               
               
                   
                 GO: 0048731~system 
                 7.36E−07 
                 1.917675905 
                 0.00010967 
               
               
                   
                 development 
               
               
                   
                 GO: 0051707~response 
                 1.25E−06 
                 4.4259178 
                 0.00017294 
               
               
                   
                 to other organism 
               
               
                   
                 GO: 0007275~multicellular 
                 2.71E−06 
                 1.742406265 
                 0.00032825 
               
               
                   
                 organismal 
               
               
                   
                 development 
               
               
                   
                 GO: 0032101~regulation 
                 2.59E−06 
                 6.287901089 
                 0.00033427 
               
               
                   
                 of response to external 
               
               
                   
                 stimulus 
               
               
                   
                 GO: 0022610~biological 
                 3.65E−06 
                 2.940010571 
                 0.00039282 
               
               
                   
                 adhesion 
               
               
                   
                 GO: 0007155~cell 
                 3.47E−06 
                 2.948386669 
                 0.00039594 
               
               
                   
                 adhesion 
               
               
                   
                 GO: 0048856~anatomical 
                 4.11E−06 
                 1.792006443 
                 0.00041352 
               
               
                   
                 structure development 
               
               
                   
                 GO: 0065008~regulation 
                 5.75E−06 
                 2.067363531 
                 0.00050661 
               
               
                   
                 of biological quality 
               
               
                   
                 GO: 0007166~cell surface 
                 5.31E−06 
                 2.24578872 
                 0.00051425 
               
               
                   
                 receptor linked signal 
               
               
                   
                 transduction 
               
               
                   
                 GO: 0050727~regulation 
                 5.72E−06 
                 8.870431894 
                 0.00052809 
               
               
                   
                 of inflammatory 
               
               
                   
                 response 
               
               
                   
                 GO: 0006950~response 
                 6.47E−06 
                 1.896821914 
                 0.0005449 
               
               
                   
                 to stress 
               
               
                   
                 GO: 0032502~developmental 
                 9.45E−06 
                 1.642672573 
                 0.00073237 
               
               
                   
                 process 
               
               
                   
                 GO: 0031347~regulation 
                 9.45E−06 
                 5.519379845 
                 0.0007628 
               
               
                   
                 of defense response 
               
               
                   
                 GO: 0009607~response 
                 1.20E−05 
                 3.375586386 
                 0.00089042 
               
               
                   
                 to biotic stimulus 
               
               
                   
                 GO: 0019955~cytokine 
                 1.09E−05 
                 6.970960427 
                 0.00131926 
               
               
                   
                 binding 
               
               
                   
                 GO: 0050776~regulation 
                 2.06E−05 
                 4.292850991 
                 0.00147588 
               
               
                   
                 of immune response 
               
               
                   
                 GO: 0040011~locomotion 
                 2.38E−05 
                 3.210251542 
                 0.00164377 
               
               
                   
                 GO: 0080134~regulation 
                 2.54E−05 
                 3.700142913 
                 0.00169407 
               
               
                   
                 of response to stress 
               
               
                   
                 GO: 0007626~locomotory 
                 3.53E−05 
                 4.081231576 
                 0.00227722 
               
               
                   
                 behavior 
               
               
                   
                 GO: 0002684~positive 
                 4.09E−05 
                 4.024547804 
                 0.00255401 
               
               
                   
                 regulation of immune 
               
               
                   
                 system process 
               
               
                   
                 GO: 0000267~cell 
                 0.00027348 
                 1.99311488 
                 0.00366864 
               
               
                   
                 fraction 
               
               
                   
                 GO: 0045028~purinergic 
                 5.12E−05 
                 13.86854232 
                 0.00411604 
               
               
                   
                 nudeotide receptor 
               
               
                   
                 activity, G-protein 
               
               
                   
                 coupled 
               
               
                   
                 GO: 0001608~nucleotide 
                 5.12E−05 
                 13.86854232 
                 0.00411604 
               
               
                   
                 receptor activity, G- 
               
               
                   
                 protein coupled 
               
               
                   
                 GO: 0004930~G-protein 
                 4.66E−05 
                 4.292644053 
                 0.00449193 
               
               
                   
                 coupled receptor activity 
               
               
                   
                 GO: 0016502~nucleotide 
                 8.64E−05 
                 12.54772877 
                 0.00594437 
               
               
                   
                 receptor activity 
               
               
                   
                 GO: 0001614~purinergic 
                 8.64E−05 
                 12.54772877 
                 0.00594437 
               
               
                   
                 nucleotide receptor 
               
               
                   
                 GO: 0005626~insoluble 
                 0.00050614 
                 2.119836435 
                 0.00638231 
               
               
                   
                 friction 
               
               
                   
                 GO: 0048513~organ 
                 0.00010948 
                 1.845652496 
                 0.00640896 
               
               
                   
                 development 
               
               
                   
                 GO: 0002697~regulation 
                 0.00010851 
                 6.009002251 
                 0.00655072 
               
               
                   
                 of immune effector 
               
               
                   
                 process 
               
               
                   
                 GO: 0051384~response 
                 0.00011695 
                 7.046016823 
                 0.00664447 
               
               
                   
                 to glucocorticoid 
               
               
                   
                 stimulus 
               
               
                   
                 GO: 0005624~membrane 
                 0.00064098 
                 2.128163382 
                 0.00762936 
               
               
                   
                 fraction 
               
               
                   
                 hsa04060:Cytokine- 
                 7.88E−05 
                 3.910866911 
                 0.00816277 
               
               
                   
                 cytokine receptor 
               
               
                   
                 interaction 
               
               
                   
                 GO: 0031349~positive 
                 0.00015337 
                 6.7584243 
                 0.00822279 
               
               
                   
                 regulation of defense 
               
               
                   
                 response 
               
               
                   
                 GO: 0048584~positive 
                 0.00015308 
                 3.789715034 
                 0.00844122 
               
               
                   
                 regulation of response to 
               
               
                   
                 stimulus 
               
               
                   
                 GO: 0031960~response 
                 0.00017474 
                 6.623255814 
                 0.00911158 
               
               
                   
                 to corticosteroid 
               
               
                   
                 stimulus 
               
               
                   
                 GO: 0042221~response 
                 0.00023157 
                 1.879298045 
                 0.01115792 
               
               
                   
                 to chemical stimulus 
               
               
                   
                 GO: 0065007~biological 
                 0.00022752 
                 1.23581669 
                 0.01124356 
               
               
                   
                 regulation 
               
               
                   
                 GO: 0050865~regulation 
                 0.00022283 
                 4.295743747 
                 0.01130118 
               
               
                   
                 of cell activation 
               
               
                   
                 GO: 0048545~response 
                 0.00025981 
                 4.216192937 
                 0.0122074 
               
               
                   
                 to steroid hormone 
               
               
                   
                 stimulus 
               
               
                   
                 GO: 0006935~chemotaxis 
                 0.00027256 
                 4.651162791 
                 0.01249951 
               
               
                   
                 GO: 0042330~taxis 
                 0.00027256 
                 4.651162791 
                 0.01249951 
               
               
                   
                 GO: 0002703~regulation 
                 0.0003028 
                 7.429934407 
                 0.01355657 
               
               
                   
                 of leukocyte mediated 
               
               
                   
                 immunity 
               
               
                   
                 GO: 0002822~regulation 
                 0.00034918 
                 7.244186047 
                 0.01492816 
               
               
                   
                 of adaptive immune 
               
               
                   
                 response based on 
               
               
                   
                 somatic recombination 
               
               
                   
                 of immune receptors 
               
               
                   
                 built from 
               
               
                   
                 immunoglobulin 
               
               
                   
                 superfamily domains 
               
               
                   
                 G0: 0001568~blood 
                 0.00034714 
                 3.471867967 
                 0.01517609 
               
               
                   
                 vessel development 
               
               
                   
                 G0: 0030154~cell 
                 0.00037713 
                 1.79379845 
                 0.01576601 
               
               
                   
                 differentiation 
               
               
                   
                 GO: 0001944~vasculature 
                 0.00039042 
                 3.42764035 
                 0.01597268 
               
               
                   
                 development 
               
               
                   
                 G0: 0002819~regulation 
                 0.00040094 
                 7.067498582 
                 0.0160609 
               
               
                   
                 of adaptive immune 
               
               
                   
                 response 
               
               
                   
                 GO: 0051241~negative 
                 0.0004538 
                 4.902080783 
                 0.01743952 
               
               
                   
                 regulation of 
               
               
                   
                 multicellular organismal 
               
               
                   
                 GO: 0051704~multi- 
                 0.00044925 
                 2.222569065 
                 0.01761538 
               
               
                   
                 organism process 
               
               
                   
                 GO: 0007165~signal 
                 0.00048801 
                 1.566926487 
                 0.01837798 
               
               
                   
                 transduction 
               
               
                   
                 GO: 0009617~response 
                 0.00051926 
                 4.267561736 
                 0.01917123 
               
               
                   
                 to bacterium 
               
               
                   
                 GO: 0048519~negative 
                 0.00057125 
                 1.628669462 
                 0.01993331 
               
               
                   
                 regulation of biological 
               
               
                   
                 process 
               
               
                   
                 GO: 0050864~regulation 
                 0.00056871 
                 8.564554932 
                 0.0202092 
               
               
                   
                 of B cell activation 
               
               
                   
                 GO: 0001525~angiogenesis 
                 0.00056006 
                 4.224015187 
                 0.02027648 
               
               
                   
                 GO: 0048869~cellular 
                 0.00059519 
                 1.735654039 
                 0.02039329 
               
               
                   
                 developments process 
               
               
                   
                 GO: 0002694~regulation 
                 0.00064956 
                 4.139534884 
                 0.02184996 
               
               
                   
                 of leukocyte activation 
               
               
                   
                 GO: 0044243~multicellular 
                 0.00070212 
                 20.69767442 
                 0.02319544 
               
               
                   
                 organismal catabolic 
               
               
                   
                 process 
               
               
                   
                 GO: 0030574~collagen 
                 0.00070212 
                 20.69767442 
                 0.02319544 
               
               
                   
                 cataboltc process 
               
               
                   
                 GO: 0016477~cell 
                 0.00071879 
                 3.203211517 
                 0.02334233 
               
               
                   
                 migration 
               
               
                   
                 GO: 0045595~regulation 
                 0.0007682 
                 2.517284727 
                 0.02373537 
               
               
                   
                 of cell differentiation 
               
               
                   
                 GO: 0032879~regulation 
                 0.0007822 
                 2.358709335 
                 0.02378398 
               
               
                   
                 of localization 
               
               
                   
                 GO: 0050729~positive 
                 0.00076295 
                 11.49870801 
                 0.0239569 
               
               
                   
                 regulation of 
               
               
                   
                 inflammatory response 
               
               
                   
                 GO: 0007186~G-protein 
                 0.00075328 
                 2.725619677 
                 0.0240464 
               
               
                   
                 coupled receptor protein 
               
               
                   
                 signaling pathway 
               
               
                   
                 GO: 0051270~regulation 
                 0.00083518 
                 3.642790698 
                 0.02498336 
               
               
                   
                 of cell motion 
               
               
                   
                 GO: 0048518~positive 
                 0.0009722 
                 1.559204424 
                 0.02858412 
               
               
                   
                 regulation of biological 
               
               
                   
                 process 
               
               
                   
                 GO: 001816~cytokine 
                 0.00105123 
                 7.526427061 
                 0.0299652 
               
               
                   
                 production 
               
               
                   
                 GO: 0007610~behavior 
                 0.00104771 
                 2.759689922 
                 0.03031177 
               
               
                   
                 GO: 00550878~regulation 
                 0.00117703 
                 4.87004104 
                 0.03300809 
               
               
                   
                 of body fluid levels 
               
               
                   
                 GO: 0032496~response 
                 0.0013154 
                 5.681714546 
                 0.03578575 
               
               
                   
                 to lipopolysaccharide 
               
               
                   
                 GO: 0002683~negative 
                 0.0013154 
                 5.681714546 
                 0.03578575 
               
               
                   
                 regulation of immune 
               
               
                   
                 GO: 0051674~localization 
                 0.00131424 
                 2.989664083 
                 0.03626342 
               
               
                   
                 of cell 
               
               
                   
                 GO: 0048870~cell motility 
                 0.00131424 
                 2.989664083 
                 0.03626342 
               
               
                   
                 GO: 0046903~secretion 
                 0.00139387 
                 3.163975707 
                 0.03684834 
               
               
                   
                 GO: 0006928~cell motion 
                 0.0013811 
                 2.469196246 
                 0.03702169 
               
               
                   
                 GO: 0048514~blood 
                 0.00142405 
                 3.398125651 
                 0.03712585 
               
               
                   
                 vessel morphogenesis 
               
               
                   
                 GO: 0001501~skeletal 
                 0.00146721 
                 3.143950545 
                 0.03772332 
               
               
                   
                 system development 
               
               
                   
                 GO: 0050867~positive 
                 0.00151961 
                 4.664264658 
                 0.03853451 
               
               
                   
                 regulation of cell 
               
               
                   
                 activation 
               
               
                   
                 GO: 0030247~polysaccharide 
                 0.0007648 
                 5.243826948 
                 0.04514181 
               
               
                   
                 binding 
               
               
                   
                 GO: 0001871~pattern 
                 0.0007648 
                 5.243826948 
                 0.04514181 
               
               
                   
                 binding 
               
               
                   
                 GO: 0004222~metalloendopeptidase 
                 0.00087418 
                 6.148387097 
                 0.04585047 
               
               
                   
                 activity 
               
               
                   
                 GO: 0002698~negative 
                 0.00196103 
                 15.05285412 
                 0.0488232 
               
               
                   
                 regulation of immune 
               
               
                   
                 effector process 
               
               
                   
                 GO: 0002698~positive 
                 0.00201705 
                 6.536107711 
                 0.04892898 
               
               
                   
                 regulation of response to 
               
               
                   
                 external stimulus 
               
               
                   
                 GO: 0010033~response 
                 0.00199539 
                 2.03004903 
                 0.04902907 
               
               
                   
                 to organic substance 
               
               
                   
                   
               
             
          
           
               
                 Term 
                 Probesets 
               
               
                   
               
             
          
           
               
                 Enriched among top downregulated genes: 
               
             
          
           
               
                 GO: 0007275~multicellular 
                 207865_S_AT, 41037_AT, 201350_AT, 229638_AT, 222162_S_AT, 204457_S_AT, 
               
               
                 organismal 
                 39966_AT, 52651_AT, 227242_S_AT, 227236_AT, 200894_S_AT, 239410_AT, 
               
               
                 development 
                 217028_AT, 206589_AT, 211299_S_AT, 208078_S_AT, 223704_S_AT, 201688_S_AT, 
               
               
                   
                 201689_S_AT, 216953_S_AT, 201690_S_AT, 229103_AT, 218326_S_AT, 202800_AT, 
               
               
                   
                 210347_S_AT, 232614_AT, 212558_AT, 206935_AT, 229084_AT, 219497_S_AT, 
               
               
                   
                 227103_S_AT, 235275_AT, 211919_S_AT, 212097_AT, 206067_S_AT, 243209_AT, 
               
               
                   
                 207725_AT, 209201_X_AT, 213478_AT, 213568_AT, 211421_S_AT, 221900_AT, 
               
               
                   
                 222891_S_AT, 203685_AT, 207717_S_AT 
               
               
                 GO: 0048731~system 
                 207865_S_AT, 41037_AT, 201350_AT, 229638_AT, 222162_S_AT, 39966_AT, 
               
               
                 development 
                 52651_AT, 227236_AT, 239410_AT, 217028_AT, 206589_AT, 211299_S_AT, 
               
               
                   
                 223704_S_AT, 201688_S_AT, 201689_S_AT, 216953_S_AT, 201690_S_AT, 
               
               
                   
                 229103_AT, 218326_S_AT, 202800_AT, 232614_AT, 210347_S_AT, 212558_AT, 
               
               
                   
                 206935_AT, 229084_AT, 219437_S_AT, 227103_S_AT, 235275_AT, 211919_S_AT, 
               
               
                   
                 206067_S_AT, 212097_AT, 243209_AT, 207725_AT, 209201_X_AT, 213478_AT, 
               
               
                   
                 213568_AT, 211421_S_AT, 221900_AT, 222891_S_AT, 203685_AT, 207717_S_AT 
               
               
                 GO: 0048513~organ 
                 207865_S_AT, 41037_AT, 201350_AT, 222162_S_AT, 52651_AT, 239410_AT, 
               
               
                 development 
                 217028_AT, 206589_AT, 211299_S_AT, 223704_S_AT, 201688_S_AT, 201689_S_AT, 
               
               
                   
                 216953_S_AT, 201690_S_AT, 229103_AT, 218326_S_AT, 232614_AT, 210347_S_AT, 
               
               
                   
                 212558_AT, 206935_AT, 229084_AT, 219497_S_AT, 227103_S_AT, 235275_AT, 
               
               
                   
                 211919_5_AT, 206067_S_AT, 212097_AT, 243209_AT, 207725_AT, 209201_X_AT, 
               
               
                   
                 213478_AT, 211421_S_AT, 213568_AT, 221900_AT, 203685_AT, 2228911_S_AT, 
               
               
                   
                 207717_S_AT 
               
               
                 GO: 0048856~anatomical 
                 207865_S_AT, 41037_AT, 201350_AT, 229638_AT, 222162_S_AT, 39966_AT, 
               
               
                 structure development 
                 52651_AT, 227236_AT, 239410_AT, 217028_AT, 206589_AT, 211299_S_AT, 
               
               
                   
                 223704_S_AT, 201688_S_AT, 201689_S_AT, 216953_S_AT, 201690_S_AT, 
               
               
                   
                 229103_AT, 218326_S_AT, 202800_AT, 232614_AT, 210347_S_AT, 212558_AT, 
               
               
                   
                 206935_AT, 229084_AT, 219497_S_AT, 227103_S_AT, 235275_AT, 211919_S_AT, 
               
               
                   
                 206067_S_AT, 212097_AT, 243203_AT, 207725_AT, 209201_X_AT, 213478_AT, 
               
               
                   
                 213568_AT, 211421_S_AT, 221900_AT, 222891_S_AT, 203685_AT, 207717_S_AT 
               
               
                 GO: 0030154~cell 
                 207865_S_AT, 213361_AT, 41037_AT, 229638_AT, 204557_S_AT, 39966_AT, 
               
               
                 differentiation 
                 227236_AT, 217028_AT, 206539_AT, 208078_S_AT, 201688_S_AT, 201688_S_AT, 
               
               
                   
                 216953_S_AT, 201690_S_AT, 229103_AT, 202800_AT, 210347_S_AT, 232614_AT, 
               
               
                   
                 212558_AT, 229084_AT, 219497_S_AT, 227103_S_AT, 235275_AT, 212097_AT, 
               
               
                   
                 206067_S_AT, 211919_S_AT, 207725_AT, 209201_X_AT, 213478_AT, 211421_S_AT, 
               
               
                   
                 222891_S_AT, 203685_AT 
               
               
                 GO: 0032502~developmental 
                 207865_S_AT, 213361_AT, 41037_AT, 201350_AT, 229638_AT, 222162_S_AT, 
               
               
                 process 
                 204557_S_AT, 39966_AT, 52651_AT, 227242_S_AT, 227236_AT, 200894_S_AT, 
               
               
                   
                 239410_AT, 217028_AT, 206589_AT, 211299_S_AT, 208078_S_AT, 223704_S_AT, 
               
               
                   
                 201688_S_AT, 201689_S_AT, 216953_S_AT, 201690_S_AT, 229103_AT, 
               
               
                   
                 218326_S_AT, 202800_AT, 210347_S_AT, 232614_AT, 212558_AT, 206935_AT, 
               
               
                   
                 229084_AT, 219497_S_AT, 227103_S_AT, 235275_AT, 211919_S_AT, 212097_AT, 
               
               
                   
                 206067_S_AT, 243209_AT, 207725_AT, 209201_X_AT, 213478_AT, 213568_AT, 
               
               
                   
                 211421_S_AT, 221900_AT, 222891_S_AT, 203685_AT, 207717_S_AT 
               
               
                 GO: 0003006~reproductive 
                 213361_AT, 218326_S_AT, 232614_AT, 222162_S_AT, 204557_S_AT, 206067_S_AT, 
               
               
                 developmental 
                 211919_S_AT, 200894_S_AT, 209201_X_AT, 217028_AT, 203685_AT, 223704_S_AT, 
               
               
                 process 
                 216953_S_AT 
               
               
                 GO: 0048869~cellular 
                 207865_S_AT, 213361_AT, 41037_AT, 229638_AT, 204557_S_AT, 39966_AT, 
               
               
                 developmental process 
                 227236_AT, 217028_AT, 206589_AT, 208078_S_AT, 201688_S_AT, 201689_S_AT, 
               
               
                   
                 216953_S_AT, 201690_S_AT, 229103_AT, 202800_AT, 210347_S_AT, 232614_AT, 
               
               
                   
                 212558_AT, 229084_AT, 219497_S_AT, 227103_S_AT, 235275_AT, 212097_AT, 
               
               
                   
                 206067_S_AT, 211919_S_AT, 207725_AT, 209201_X_AT, 213478_AT, 211421_S_AT, 
               
               
                   
                 222891_S_AT, 203685_AT 
               
               
                 GO: 0009653~anatomical 
                 41037_AT, 222162_S_AT, 526S1_AT, 217028_AT, 206589_AT, 201688_S_AT, 
               
               
                 structure morphogenesis 
                 201689_S_AT, 216953_S_AT, 201690_S_AT, 229103_AT, 218326_S_AT, 202800_AT, 
               
               
                   
                 232614_AT, 229084_AT, 206935_AT, 206067_S_AT, 211919_S_AT, 212097_AT, 
               
               
                   
                 243209_AT, 207725_AT, 213568_AT, 211421_S_AT, 209201_X_AT, 221900_AT, 
               
               
                   
                 203685_AT 
               
             
          
           
               
                 Enriched among top upregulated genes: 
               
             
          
           
               
                 GO: 0005886~plasma 
                 219358_S_AT, 1553995_A_AT, 210495_X_AT, 229221_AT, 223723_AT, 212298_AT, 
               
               
                 membrane 
                 209555_S_AT, 223660_AT, 211066_X_AT, 219412_AT, 205798_AT, 228579_AT, 
               
               
                   
                 230360_AT, 226545_AT, 242903_AT, 207610_S_AT, 220307_AT, 226629_AT, 
               
               
                   
                 201590_X_AT, 203922_S_AT, 229937_X_AT, 214830_AT, 203104_AT, 212977_AT, 
               
               
                   
                 202756_S_AT, 228766_AT, 230925_AT, 243556_AT, 201005_AT, 201242_S_AT, 
               
               
                   
                 242907_AT, 209122_AT, 205128_X_AT, 214211_AT, 237252_AT, 214297_AT, 
               
               
                   
                 202727_S_AT, 221060_S_AT, 211719_X_AT, 223596_AT, 223501_AT, 205898_AT, 
               
               
                   
                 34210_AT, 205099_S_AT, 218613_AT, 210146_X_AT, 215836_S_AT, 217678_AT, 
               
               
                   
                 232068_S_AT, 209047_AT, 238581_AT, 1554992_AT, 209906_AT, 243483_AT, 
               
               
                   
                 210510_S_AT, 211030_S_AT, 211676_S_AT, 208121_S_AT, 238669_AT, 
               
               
                   
                 204105_S_AT, 219994_AT, 201125_S_AT, 203355_S_AT, 202638_S_AT, 
               
               
                   
                 201243_S_AT, 204912_AT, 201069_AT, 206206_AT, 228918_AT, 222877_AT, 
               
               
                   
                 227134_AT, 203217_S_AT, 229900_AT, 244375_AT, 206488_S_AT, 206171_AT, 
               
               
                   
                 208789_AT, 1553151_AT, 220066_AT, 228640_AT, 237442_AT, 203939_AT, 
               
               
                   
                 205542_AT, 218589_AT, 243894_AT, 213428_S_AT, 205891_AT, 203665_AT, 
               
               
                   
                 207542_S_AT, 202748_AT, 208816_X_AT, 239519_AT, 208161_S_AT, 221266_S_AT, 
               
               
                   
                 209921_AT, 223502_S_AT, 1557938_S_AT, 212086_X_AT, 220484_AT, 
               
               
                   
                 203887_S_AT, 224341_X_AT, 223939_AT, 206637_AT, 1555756_A_AT, 209392_AT, 
               
               
                   
                 209993_AT, 215813_S_AT, 201324_AT, 212464_S_AT, 216442_X_AT, 213503_X_AT, 
               
               
                   
                 227240_AT, 210427_X_AT, 202609_AT, 214724_AT, 226218_AT, 204661_AT, 
               
               
                   
                 211661_X_AT, 210895_S_AT, 222062_AT, 204116_AT, 232746_AT, 223092_AT, 
               
               
                   
                 225188_AT, 202827_S_AT, 205419_AT, 235299_AT, 1560960_AT, 201952_AT, 
               
               
                   
                 225189_S_AT, 1552798_A_AT, 210264_AT, 205718_AT, 237904_AT, 203888_AT, 
               
               
                   
                 223798_AT, 212096_S_AT, 210258_AT, 210004_AT, 222876_S_AT, 229797_AT, 
               
               
                   
                 218223_S_AT, 241929_AT, 219434_AT, 201951_AT 
               
               
                 GO: 0031226~intrinsic to 
                 223723_AT, 229221_AT, 209555_S_AT, 223660_AT, 203217_S_AT, 206488_S_AT, 
               
               
                 plasma membrane 
                 206171_AT, 228579_AT, 228640_AT, 242903_AT, 205542_AT, 205891_AT, 
               
               
                   
                 207542_S_AT, 208161_S_AT, 203922_S_AT, 203104_AT, 202756_S_AT, 
               
               
                   
                 224341_X_AT, 203887_S_AT, 228766_AT, 209392_AT, 201005_AT, 201242_S_AT, 
               
               
                   
                 237252_AT, 214297_AT, 202727_S_AT, 221060_S_AT, 202609_AT, 223596_AT, 
               
               
                   
                 34210_AT, 204661_AT, 205898_AT, 205099_S_AT, 211661_X_AT, 222062_AT, 
               
               
                   
                 204116_AT, 210146_X_AT, 202827_S_AT, 223092_AT, 209047_AT, 205419_AT, 
               
               
                   
                 232068_S_AT, 209906_AT, 1560960_AT, 211030_S_AT, 210264_AT, 211676_S_AT, 
               
               
                   
                 208121_S_AT, 1552798_A_AT, 205718_AT, 237904_AT, 203888_AT, 204105_S_AT, 
               
               
                   
                 210004_AT, 241929_AT, 201125_S_AT, 202638_S_AT, 201243_S_AT 
               
               
                 GO: 0016020~membrane 
                 1553995_A_AT, 223723_AT, 212298_AT, 223660_AT, 222838_AT, 219412_AT, 
               
               
                   
                 205798_AT, 205960_AT, 228579_AT, 238681_AT, 217997_AT, 226545_AT, 
               
               
                   
                 227747_AT, 205505_AT, 220307_AT, 226629_AT, 216080_S_AT, 201590_X_AT, 
               
               
                   
                 203922_S_AT, 218686_S_AT, 221815_AT, 203104_AT, 202756_S_AT, 228766_AT, 
               
               
                   
                 205128_X_AT, 214211_AT, 214581_X_AT, 63825_AT, 211719_X_AT, 223501_AT, 
               
               
                   
                 205898_AT, 205099_S_AT, 219574_AT, 210146_X_AT, 215836_S_AT, 235944_AT, 
               
               
                   
                 209047_AT, 240076_AT, 1554992_AT, 219926_AT, 235458_AT, 211676_S_AT, 
               
               
                   
                 225842_AT, 238669_AT, 204257_AT, 204105_S_AT, 224989_AT, 206134_AT, 
               
               
                   
                 202638_S_AT, 239761_AT, 201243_S_AT, 204312_AT, 238638_AT, 228318_AT, 
               
               
                   
                 227134_AT, 222877_AT, 212062_AT, 202434_S_AT, 222858_S_AT, 204222_S_AT, 
               
               
                   
                 229900_AT, 241392_AT, 206488_S_AT, 208789_AT, 1553151_AT, 220066_AT, 
               
               
                   
                 228640_AT, 205542_AT, 213338_AT, 203665_AT, 205891_AT, 202748_AT, 
               
               
                   
                 208816_X_AT, 239519_AT, 208161_S_AT, 218856_AT, 210145_AT, 223502_S_AT, 
               
               
                   
                 227889_AT, 236345_AT, 1557938_S_AT, 205003_AT, 212086_X_AT, 223939_AT, 
               
               
                   
                 203887_S_AT, 206637_AT, 211138_S_AT, 1555756_A_AT, 215813_S_AT, 
               
               
                   
                 227240_AT, 210427_X_AT, 226218_AT, 204661_AT, 225809_AT, 210895_S_AT, 
               
               
                   
                 222062_AT, 232746_AT, 210512_S_AT, 225188_AT, 211527_X_AT, 224990_AT, 
               
               
                   
                 1560960_AT, 201952_AT, 225189_S_AT, 210264_AT, 205718_AT, 210258_AT, 
               
               
                   
                 210757_X_AT, 222876_S_AT, 210004_AT, 229797_AT, 201280_S_AT, 201951_AT, 
               
               
                   
                 220333_AT, 219358_S_AT, 210495_X_AT, 229221_AT, 209555_S_AT, 202435_S_AT, 
               
               
                   
                 211066_X_AT, 217999_S_AT, 224480_S_AT, 242871_AT, 214255_AT, 230360_AT, 
               
               
                   
                 242903_AT, 228490_AT, 207610_S_AT, 229937_X_AT, 214830_AT, 227052_AT, 
               
               
                   
                 212977_AT, 230925_AT, 243556_AT, 201005_AT, 201242_S_AT, 242907_AT, 
               
               
                   
                 209122_AT, 237252_AT, 212171_X_AT, 214297_AT, 237030_AT, 202727_S_AT, 
               
               
                   
                 221060_S_AT, 223596_AT, 34210_AT, 205566_AT, 218613_AT, 217678_AT, 
               
               
                   
                 232068_S_AT, 238581_AT, 57715_AT, 209906_AT, 243483_AT, 210510_S_AT, 
               
               
                   
                 210513_S_AT, 211030_S_AT, 208121_S_AT, 223434_AT, 204881_S_AT, 225097_AT, 
               
               
                   
                 219994_AT, 205306_X_AT, 203355_S_AT, 201125_S_AT, 226136_AT, 201069_AT, 
               
               
                   
                 206206_AT, 203217_S_AT, 201278_AT, 244375_AT, 206171_AT, 218854_AT, 
               
               
                   
                 237442_AT, 203939_AT, 218589_AT, 243894_AT, 213428_S_AT, 202436_S_AT, 
               
               
                   
                 207542_S_AT, 221565_S_AT, 201279_S_AT, 219386_S_AT, 221266_S_AT, 
               
               
                   
                 209921_AT, 225337_AT, 220484_AT, 224341_X_AT, 228762_AT, 209392_AT, 
               
               
                   
                 201324_AT, 209993_AT, 212464_S_AT, 1555606_A_AT, 216442_X_AT, 
               
               
                   
                 213503_X_AT, 228708_AT, 202609_AT, 214724_AT, 211661_X_AT, 214841_AT, 
               
               
                   
                 204116_AT, 225207_AT, 219385_AT, 202827_S_AT, 223092_AT, 87100_AT, 
               
               
                   
                 205419_AT, 235286_AT, 235299_AT, 1554285_AT, 202437_S_AT, 1552798_A_AT, 
               
               
                   
                 203888_AT, 237904_AT, 223798_AT, 212096_S_AT, 218223_S_AT, 241929_AT, 
               
               
                   
                 219434_AT 
               
               
                 GO: 0005887~integral to 
                 223723_AT, 229221_AT, 209555_S_AT, 223660_AT, 203217_S_AT, 206488_S_AT, 
               
               
                 plasma membrane 
                 206171_AT, 228579_AT, 228640_AT, 242903_AT, 205542_AT, 205891_AT, 
               
               
                   
                 207542_S_AT, 208161_S_AT, 203922_S_AT, 203104_AT, 202756_S_AT, 
               
               
                   
                 224341_X_AT, 203887_S_AT, 228766_AT, 209392_AT, 201005_AT, 201242_S_AT, 
               
               
                   
                 237252_AT, 214297_AT, 202727_S_AT, 221060_S_AT, 202609_AT, 223596_AT, 
               
               
                   
                 34210_AT, 204661_AT, 205898_AT, 205099_S_AT, 211661_X_AT, 222062_AT, 
               
               
                   
                 204116_AT, 210146_X_AT, 202827_S_AT, 223092_AT, 209047_AT, 205419_AT, 
               
               
                   
                 232068_S_AT, 209906_AT, 211030_S_AT, 210264_AT, 211676_S_AT, 208121_S_AT, 
               
               
                   
                 1552798_A_AT, 205718_AT, 237904_AT, 203888_AT, 204105_S_AT, 210004_AT, 
               
               
                   
                 241929_AT, 201125_S_AT, 202638_S_AT, 201243_S_AT 
               
               
                 GO: 0044459~plasma 
                 210495_X_AT, 223723_AT, 229221_AT, 209555_S_AT, 223660_AT, 227134_AT, 
               
               
                 membrane part 
                 203217_S_AT, 219412_AT, 205798_AT, 206488_S_AT, 244375_AT, 206171_AT, 
               
               
                   
                 228579_AT, 208789_AT, 1553151_AT, 228640_AT, 237442_AT, 242903_AT, 
               
               
                   
                 205542_AT, 203665_AT, 205891_AT, 207542_S_AT, 202748_AT, 220307_AT, 
               
               
                   
                 208161_S_AT, 203922_S_AT, 214830_AT, 1557938_S_AT, 203104_AT, 
               
               
                   
                 202756_S_AT, 224341_X_AT, 203887_S_AT, 228766_AT, 1555756_A_AT, 
               
               
                   
                 230925_AT, 209332_AT, 201005_AT, 201242_S_AT, 209993_AT, 242907_AT, 
               
               
                   
                 212464_S_AT, 237252_AT, 216442_X_AT, 214297_AT, 202727_S_AT, 221060_S_AT, 
               
               
                   
                 211719_X_AT, 202609_AT, 214724_AT, 223596_AT, 226218_AT, 34210_AT, 
               
               
                   
                 204661_AT, 205898_AT, 205099_S_AT, 211661_X_AT, 210895_S_AT, 218613_AT, 
               
               
                   
                 222062_AT, 204116_AT, 210146_X_AT, 202827_S_AT, 223092_AT, 225188_AT, 
               
               
                   
                 209047_AT, 205419_AT, 232068_S_AT, 238581_AT, 209906_AT, 1560960_AT, 
               
               
                   
                 243483_AT, 201952_AT, 225189_S_AT, 211030_S_AT, 210264_AT, 211676_S_AT, 
               
               
                   
                 208121_S_AT, 1552798_A_AT, 205718_AT, 237904_AT, 203888_AT, 204105_S_AT, 
               
               
                   
                 210004_AT, 219994_AT, 241929_AT, 203355_S_AT, 201125_S_AT, 201951_AT, 
               
               
                   
                 202638_S_AT, 201243_S_AT 
               
               
                 GO: 0005576~extracellular 
                 226136_AT, 223221_AT, 223723_AT, 210495_X_AT, 201069_AT, 212298_AT, 
               
               
                 region 
                 205798_AT, 204222_S_AT, 229900_AT, 203936_S_AT, 226545_AT, 37145_AT, 
               
               
                   
                 203665_AT, 213428_S_AT, 208816_X_AT, 239519_AT, 201590_X_AT, 212190_AT, 
               
               
                   
                 223502_S_AT, 206157_AT, 212143_S_AT, 202458_AT, 203887_S_AT, 202756_S_AT, 
               
               
                   
                 201422_AT, 204834_AT, 205495_S_AT, 228873_AT, 209392_AT, 228762_AT, 
               
               
                   
                 210095_S_AT, 213265_AT, 209122_AT, 212464_S_AT, 237252_AT, 216442_X_AT, 
               
               
                   
                 237030_AT, 212171_X_AT, 213503_X_AT, 204575_S_AT, 1405_I_AT, 210427_X_AT, 
               
               
                   
                 211719_X_AT, 226218_AT, 223501_AT, 206835_AT, 207433_AT, 227265_AT, 
               
               
                   
                 235944_AT, 210512_S_AT, 202827_S_AT, 221463_AT, 211527_X_AT, 204475_AT, 
               
               
                   
                 235286_AT, 217757_AT, 229004_AT, 204655_AT, 210510_S_AT, 210513_S_AT, 
               
               
                   
                 203888_AT, 210004_AT, 206134_AT, 202087_S_AT, 1555759_A_AT, 1556423_AT, 
               
               
                   
                 219434_AT, 202638_S_AT 
               
               
                 GO: 0031224~intrinsic to 
                 220333_AT, 1553995_A_AT, 229221_AT, 223723_AT, 212298_AT, 209555_S_AT, 
               
               
                 membrane 
                 223660_AT, 222838_AT, 211066_X_AT, 205798_AT, 224480_S_AT, 214255_AT, 
               
               
                   
                 242871_AT, 238681_AT, 228579_AT, 230360_AT, 226545_AT, 242903_AT, 
               
               
                   
                 227747_AT, 228490_AT, 207610_S_AT, 205505_AT, 220307_AT, 226629_AT, 
               
               
                   
                 216080_S_AT, 203922_S_AT, 218686_S_AT, 229937_X_AT, 221815_AT, 214830_AT, 
               
               
                   
                 227052_AT, 203104_AT, 212977_AT, 202756_S_AT, 228766_AT, 201005_AT, 
               
               
                   
                 201242_S_AT, 214581_X_AT, 237252_AT, 237030_AT, 214297_AT, 63825_AT, 
               
               
                   
                 202727_S_AT, 221060_S_AT, 223596_AT, 223501_AT, 205898_AT, 34210_AT, 
               
               
                   
                 205099_S_AT, 205566_AT, 219574_AT, 210146_X_AT, 215836_S_AT, 217678_AT, 
               
               
                   
                 232068_S_AT, 240076_AT, 209047_AT, 57715_AT, 209906_AT, 243483_AT, 
               
               
                   
                 210510_S_AT, 211030_S_AT, 235458_AT, 219926_AT, 211676_S_AT, 208121_S_AT, 
               
               
                   
                 204257_AT, 223434_AT, 224989_AT, 204105_S_AT, 204881_S_AT, 206134_AT, 
               
               
                   
                 205306_X_AT, 201125_S_AT, 202638_S_AT, 239761_AT, 201243_S_AT, 226136_AT, 
               
               
                   
                 204912_AT, 238638_AT, 206206_AT, 228918_AT, 222877_AT, 203217_S_AT, 
               
               
                   
                 212062_AT, 229900_AT, 204222_S_AT, 206488_S_AT, 241392_AT, 206171_AT, 
               
               
                   
                 218854_AT, 228640_AT, 203939_AT, 205542_AT, 213318_AT, 218589_AT, 
               
               
                   
                 243894_AT, 205831_AT, 207542_S_AT, 221565_S_AT, 239519_AT, 219386_S_AT, 
               
               
                   
                 208161_S_AT, 221266_S_AT, 209921_AT, 218856_AT, 210145_AT, 227889_AT, 
               
               
                   
                 223502_S_AT, 225337_AT, 236345_AT, 220484_AT, 203887_S_AT, 224341_X_AT, 
               
               
                   
                 223939_AT, 206637_AT, 211138_S_AT, 1555756_A_AT, 209392_AT, 228762_AT, 
               
               
                   
                 209993_AT, 201324_AT, 1555606_A_AT, 228708_AT, 202609_AT, 226218_AT, 
               
               
                   
                 204661_AT, 225809_AT, 211661_X_AT, 214841_AT, 210895_S_AT, 222062_AT, 
               
               
                   
                 232746_AT, 204116_AT, 219385_AT, 223092_AT, 202827_S_AT, 205419_AT, 
               
               
                   
                 87100_AT, 235286_AT, 224990_AT, 235299_AT, 1560960_AT, 1554285_AT, 
               
               
                   
                 201952_AT, 1552798_A_AT, 210264_AT, 205718_AT, 237904_AT, 203888_AT, 
               
               
                   
                 223798_AT, 210004_AT, 229797_AT, 241929_AT, 219434_AT, 201951_AT 
               
               
                 GO: 0004871~signal 
                 220333_AT, 204912_AT, 229221_AT, 212298_AT, 209555_S_AT, 223660_AT, 
               
               
                 transducer activity 
                 206206_AT, 222838_AT, 222877_AT, 205798_AT, 206488_S_AT, 205960_AT, 
               
               
                   
                 206171_AT, 242871_AT, 200878_AT, 242903_AT, 218589_AT, 203760_S_AT, 
               
               
                   
                 203665_AT, 205891_AT, 207610_S_AT, 220307_AT, 239519_AT, 218856_AT, 
               
               
                   
                 218686_S_AT, 229937_X_AT, 203104_AT, 212977_AT, 223939_AT, 224341_X_AT, 
               
               
                   
                 203887_S_AT, 206637_AT, 228766_AT, 1555756_A_AT, 209332_AT, 214581_X_AT, 
               
               
                   
                 237252_AT, 214297_AT, 202727_S_AT, 1405_I_AT, 221060_S_AT, 202609_AT, 
               
               
                   
                 214724_AT, 226218_AT, 205898_AT, 205099_S_AT, 211661_X_AT, 210895_S_AT, 
               
               
                   
                 222062_AT, 204116_AT, 232746_AT, 225207_AT, 210146_X_AT, 235944_AT, 
               
               
                   
                 205419_AT, 232068_S_AT, 209906_AT, 243483_AT, 210510_S_AT, 204655_AT, 
               
               
                   
                 214054_AT, 211676_S_AT, 208121_S_AT, 1552798_A_AT, 210264_AT, 
               
               
                   
                 206675_S_AT, 205718_AT, 203888_AT, 237904_AT, 203761_AT, 210258_AT, 
               
               
                   
                 210004_AT, 1555759_A_AT, 241929_AT, 201125_S_AT, 219434_AT, 202638_S_AT 
               
               
                 GO: 0060089~molecular 
                 220333_AT, 204912_AT, 229221_AT, 212298_AT, 209555_S_AT, 223660_AT, 
               
               
                 transducer activity 
                 206206_AT, 222838_AT, 222877_AT, 205798_AT, 206488_S_AT, 205960_AT, 
               
               
                   
                 206171_AT, 242871_AT, 200878_AT, 242903_AT, 218589_AT, 203760_S_AT, 
               
               
                   
                 203665_AT, 205891_AT, 207610_S_AT, 220307_AT, 239519_AT, 218556_AT, 
               
               
                   
                 218686_S_AT, 229937_X_AT, 203104_AT, 212977_AT, 223939_AT, 224341_X_AT, 
               
               
                   
                 203887_S_AT, 206637_AT, 228766_AT, 1555756_A_AT, 209392_AT, 214581_X_AT, 
               
               
                   
                 237252_AT, 214297_AT, 202727_S_AT, 1405_I_AT, 221060_S_AT, 202609_AT, 
               
               
                   
                 214724_AT, 226218_AT, 205898_AT, 205099_S_AT, 211661_X_AT, 210895_S_AT, 
               
               
                   
                 222062_AT, 204116_AT, 232746_AT, 225207_AT, 210146_X_AT, 235944_AT, 
               
               
                   
                 205419_AT, 232068_S_AT, 209906_AT, 243483_AT, 210510_S_AT, 204655_AT, 
               
               
                   
                 214054_AT, 211676_S_AT, 208121_S_AT, 1552798_A_AT, 210264_AT, 
               
               
                   
                 206675_S_AT, 205718_AT, 203888_AT, 237904_AT, 203761_AT, 210258_AT, 
               
               
                   
                 210004_AT, 1555759_A_AT, 241929_AT, 201125_S_AT, 219434_AT, 202638_S_AT 
               
               
                 GO: 0004872~receptor 
                 220333_AT, 229221_AT, 204912_AT, 212298_AT, 209555_S_AT, 223660_AT, 
               
               
                 activity 
                 206206_AT, 222838_AT, 222877_AT, 205798_AT, 206488_S_AT, 206171_AT, 
               
               
                   
                 242871_AT, 242903_AT, 218589_AT, 205891_AT, 207610_S_AT, 220307_AT, 
               
               
                   
                 239519_AT, 218856_AT, 218686_S_AT, 229937_X_AT, 203104_AT, 212977_AT, 
               
               
                   
                 223939_AT, 224341_X_AT, 203887_S_AT, 228766_AT, 206637_AT, 1555756_A_AT, 
               
               
                   
                 209392_AT, 214581_X_AT, 237252_AT, 202727_S_AT, 221060_S_AT, 202609_AT, 
               
               
                   
                 226218_AT, 205898_AT, 205099_S_AT, 211661_X_AT, 210895_S_AT, 222062_AT, 
               
               
                   
                 204116_AT, 232746_AT, 210146_X_AT, 235944_AT, 205419_AT, 232068_S_AT, 
               
               
                   
                 209906_AT, 243483_AT, 210510_S_AT, 210264_AT, 208121_S_AT, 211676_S_AT, 
               
               
                   
                 1552798_A_AT, 205718_AT, 237904_AT, 203888_AT, 210004_AT, 241929_AT, 
               
               
                   
                 201125_S_AT, 219434_AT, 202638_S_AT 
               
               
                 GO: 0044425~membrane 
                 1553995_A_AT, 220333_AT, 210495_X_AT, 229221_AT, 223723_AT, 212298_AT, 
               
               
                 part 
                 209555_S_AT, 202435_S_AT, 223660_AT, 222838_AT, 211066_X_AT, 219412_AT, 
               
               
                   
                 205798_AT, 224480_S_AT, 214255_AT, 242871_AT, 238681_AT, 228579_AT, 
               
               
                   
                 230360_AT, 226545_AT, 227747_AT, 242903_AT, 228490_AT, 207610_S_AT, 
               
               
                   
                 205505_AT, 220307_AT, 226629_AT, 216080_S_AT, 203922_S_AT, 218686_S_AT, 
               
               
                   
                 229937_X_AT, 221815_AT, 214830_AT, 227052_AT, 203104_AT, 212977_AT, 
               
               
                   
                 202756_S_AT, 228766_AT, 230925_AT, 201005_AT, 201242_S_AT, 242907_AT 
               
               
                   
                 209122_AT, 205128_X_AT, 214581_X_AT, 237252_AT, 237030_AT, 214297_AT, 
               
               
                   
                 63825_AT, 202727_S_AT, 221060_S_AT, 211719_X_AT, 223596_AT, 223501_AT, 
               
               
                   
                 205898_AT, 34210_AT, 205099_S_AT, 205566_AT, 219574_AT, 218613_AT, 
               
               
                   
                 210146_X_AT, 215836_S_AT, 217678_AT, 232068_S_AT, 240076_AT, 209047_AT, 
               
               
                   
                 238581_AT, 57715_AT, 209906_AT, 243483_AT, 210510_S_AT, 211030_S_AT, 
               
               
                   
                 235458_AT, 219926_AT, 208121_S_AT, 211676_S_AT, 238669_AT, 204257_AT, 
               
               
                   
                 223434_AT, 224989_AT, 204105_S_AT, 204881_S_AT, 206134_AT, 205306_X_AT, 
               
               
                   
                 219994_AT, 201125_S_AT, 203355_S_AT, 202638_S_AT, 239761_AT, 201243_S_AT, 
               
               
                   
                 226136_AT, 204912_AT, 238638_AT, 206206_AT, 228918_AT, 222877_AT, 
               
               
                   
                 227134_AT, 203217_S_AT, 212062_AT, 202434_S_AT, 222858_S_AT, 201278_AT, 
               
               
                   
                 229900_AT, 204222_S_AT, 244375_AT, 206488_S_AT, 241392_AT, 206171_AT, 
               
               
                   
                 218854_AT, 1553151_AT, 208789_AT, 228640_AT, 203939_AT, 237442_AT, 
               
               
                   
                 205542_AT, 213338_AT, 243894_AT, 218589_AT, 205891_AT, 203665_AT, 
               
               
                   
                 202436_S_AT, 221565_S_AT, 207542_S_AT, 201279_S_AT, 202748_AT, 239519_AT, 
               
               
                   
                 219386_S_AT, 208161_S_AT, 221266_S_AT, 209921_AT, 218856_AT, 210145_AT, 
               
               
                   
                 227889_AT, 223502_S_AT, 225337_AT, 236345_AT, 1557938_S_AT, 205003_AT, 
               
               
                   
                 220484_AT, 203887_S_AT, 224341_X_AT, 223939_AT, 206637_AT, 211138_S_AT, 
               
               
                   
                 1555756_A_AT, 209392_AT, 228762_AT, 209993_AT, 201324_AT, 215813_S_AT, 
               
               
                   
                 212464_S_AT, 1555606_A_AT, 216442_X_AT, 228708_AT, 202609_AT, 214724_AT, 
               
               
                   
                 226218_AT, 204661_AT, 225809_AT, 211661_X_AT, 214841_AT, 210895_S_AT, 
               
               
                   
                 222062_AT, 232746_AT, 204116_AT, 219385_AT, 223092_AT, 225188_AT, 
               
               
                   
                 202827_S_AT, 205419_AT, 87100_AT, 235286_AT, 224990_AT, 235299_AT, 
               
               
                   
                 1560960_AT, 201952_AT, 1554285_AT, 202437_S_AT, 225189_S_AT, 
               
               
                   
                 1552798_A_AT, 210264_AT, 205718_AT, 237904_AT, 203888_AT, 223798_AT, 
               
               
                   
                 210757_X_AT, 210004_AT, 229797_AT, 201280_S_AT, 241929_AT, 219434_AT, 
               
               
                   
                 201951_AT 
               
               
                 GO: 0016021~integral to 
                 220333_AT, 229221_AT, 223723_AT, 212298_AT, 209555_S_AT, 223660_AT, 
               
               
                 membrane 
                 222838_AT, 211066_X_AT, 205798_AT, 224480_S_AT, 214255_AT, 242871_AT, 
               
               
                   
                 238681_AT, 228579_AT, 230360_AT, 242903_AT, 227747_AT, 228490_AT, 
               
               
                   
                 207610_S_AT, 205505_AT, 220307_AT, 226629_AT, 216080_S_AT, 203922_S_AT, 
               
               
                   
                 218686_S_AT, 229937_X_AT, 221815_AT, 214830_AT, 227052_AT, 203104_AT, 
               
               
                   
                 212977_AT, 202756_S_AT, 228766_AT, 201005_AT, 201242_S_AT, 214581_X_AT, 
               
               
                   
                 237252_AT, 237030_AT, 214297_AT, 63825_AT, 202727_S_AT, 221060_S_AT, 
               
               
                   
                 223536_AT, 223501_AT, 205898_AT, 34210_AT, 205099_S_AT, 205566_AT, 
               
               
                   
                 219574_AT, 210146_X_AT, 215836_S_AT, 217678_AT, 232068_S_AT, 240076_AT, 
               
               
                   
                 209047_AT, 57715_AT, 209906_AT, 243483_AT, 210510_S_AT, 211030_S_AT, 
               
               
                   
                 235458_AT, 219926_AT, 211676_S_AT, 208121_S_AT, 204257_AT, 223434_AT, 
               
               
                   
                 224989_AT, 204105_S_AT, 204881_S_AT, 206134_AT, 205306_X_AT, 201125_S_AT, 
               
               
                   
                 202638_S_AT, 239761_AT, 201243_S_AT, 226136_AT, 204912_AT, 238638_AT, 
               
               
                   
                 206206_AT, 228918_AT, 222877_AT, 203217_S_AT, 212062_AT, 204222_S_AT, 
               
               
                   
                 206488_S_AT, 241392_AT, 206171_AT, 218854_AT, 228640_AT, 205542_AT, 
               
               
                   
                 213338_AT, 218589_AT, 243894_AT, 205891_AT, 207542_S_AT, 221565_S_AT, 
               
               
                   
                 239519_AT, 219386_S_AT, 208161_S_AT, 221266_S_AT, 209921_AT, 218856_AT, 
               
               
                   
                 210145_AT, 227889_AT, 223502_S_AT, 225337_AT, 236345_AT, 220484_AT, 
               
               
                   
                 203887_S_AT, 224341_X_AT, 223939_AT, 206637_AT, 211138_S_AT, 
               
               
                   
                 1555756_A_AT, 209392_AT, 228762_AT, 209993_AT, 201324_AT, 1555606_A_AT, 
               
               
                   
                 202609_AT, 226218_AT, 204661_AT, 225809_AT, 211661_X_AT, 214841_AT, 
               
               
                   
                 210895_S_AT, 222062_AT, 232746_AT, 204116_AT, 219385_AT, 223092_AT, 
               
               
                   
                 202827_S_AT, 205419_AT, 87100_AT, 235286_AT, 224990_AT, 235299_AT, 
               
               
                   
                 1554285_AT, 201952_AT, 1552798_A_AT, 210264_AT, 205718_AT, 237904_AT, 
               
               
                   
                 203888_AT, 223798_AT, 210004_AT, 229797_AT, 241929_AT, 219434_AT, 
               
               
                   
                 201951_AT 
               
               
                 GO: 0044421~extracellular 
                 237252_AT, 229221_AT, 216442_X_AT, 210495_X_AT, 201069_AT, 212171_X_AT, 
               
               
                 region part 
                 213503_X_AT, 204575_S_AT, 1405_I_AT, 210427_X_AT, 211719_X_AT, 223501_AT, 
               
               
                   
                 229900_AT, 207433_AT, 227265_AT, 203936_S_AT, 235944_AT, 210512_S_AT, 
               
               
                   
                 202827_S_AT, 221463_AT, 226545_AT, 211527_X_AT, 204475_AT, 235286_AT, 
               
               
                   
                 37145_AT, 203665_AT, 213428_S_AT, 217757_AT, 229004_AT, 208816_X_AT, 
               
               
                   
                 204655_AT, 210513_S_AT, 201590_X_AT, 212190_AT, 223502_S_AT, 203888_AT, 
               
               
                   
                 212143_S_AT, 203887_S_AT, 202756_S_AT, 204834_AT, 205495_S_AT, 228873_AT, 
               
               
                   
                 1555759_A_AT, 1556423_AT, 210095_S_AT, 202638_S_AT, 212464_S_AT 
               
               
                 GO: 0004888~transmembrane 
                 237252_AT, 204912_AT, 212298_AT, 209555_S_AT, 223660_AT, 202727_S_AT, 
               
               
                 receptor activity 
                 221060_S_AT, 222877_AT, 226218_AT, 205898_AT, 205099_S_AT, 211661_X_AT, 
               
               
                   
                 205798_AT, 206488_S_AT, 222062_AT, 204116_AT, 232746_AT, 206171_AT, 
               
               
                   
                 235944_AT, 232068_S_AT, 205419_AT, 242903_AT, 218589_AT, 209906_AT, 
               
               
                   
                 205891_AT, 207610_S_AT, 210510_S_AT, 239519_AT, 210264_AT, 1552798_A_AT, 
               
               
                   
                 208121_S_AT, 211676_S_AT, 237904_AT, 203888_AT, 203104_AT, 212977_AT, 
               
               
                   
                 203887_S_AT, 224341_X_AT, 223939_AT, 210004_AT, 228766_AT, 206637_AT, 
               
               
                   
                 209392_AT, 241929_AT, 202638_S_AT 
               
               
                 GO: 0006955~immune 
                 214211_AT, 202869_AT, 212171_X_AT, 205552_S_AT, 1405_I_AT, 221060_S_AT, 
               
               
                 response 
                 206206_AT, 222838_AT, 226218_AT, 223501_AT, 205099_S_AT, 211661_X_AT, 
               
               
                   
                 205798_AT, 210895_S_AT, 222062_AT, 204116_AT, 207433_AT, 210146_X_AT, 
               
               
                   
                 210512_S_AT, 232068_S_AT, 221463_AT, 220066_AT, 205419_AT, 211527_X_AT, 
               
               
                   
                 238581_AT, 202748_AT, 204655_AT, 210513_S_AT, 1552798_A_AT, 203922_S_AT, 
               
               
                   
                 229937_X_AT, 223502_S_AT, 206157_AT, 223434_AT, 224341_X_AT, 210004_AT, 
               
               
                   
                 206637_AT, 1555756_A_AT, 1555759_A_AT, 209392_AT, 219434_AT, 242907_AT, 
               
               
                   
                 202638_S_AT, 213293_S_AT 
               
               
                 GO: 0009611~response 
                 210495_X_AT, 229221_AT, 212298_AT, 209555_S_AT, 223660_AT, 206206_AT, 
               
               
                 to wounding 
                 206488_S_AT, 206171_AT, 228490_AT, 203665_AT, 239519_AT, 203922_S_AT, 
               
               
                   
                 221815_AT, 206157_AT, 225337_AT, 224341_X_AT, 203887_S_AT, 228766_AT, 
               
               
                   
                 1555756_A_AT, 201005_AT, 203060_S_AT, 212464_S_AT, 237252_AT, 
               
               
                   
                 216442_X_AT, 63825_AT, 1405_I_AT, 221060_S_AT, 211719_X_AT, 205898_AT, 
               
               
                   
                 205099_S_AT, 211661_X_AT, 205566_AT, 207433_AT, 211026_S_AT, 235944_AT, 
               
               
                   
                 221463_AT, 87100_AT, 232068_S_AT, 208436_S_AT, 204465_S_AT, 209906_AT, 
               
               
                   
                 217757_AT, 210510_S_AT, 204655_AT, 1552553_A_AT, 1552798_A_AT, 203888_AT, 
               
               
                   
                 237904_AT, 210004_AT, 1555759_A_AT, 241929_AT 
               
               
                 GO: 0009605~response 
                 229221_AT, 210495_X_AT, 212298_AT, 209555_S_AT, 223660_AT, 206206_AT, 
               
               
                 to external stimulus 
                 222877_AT, 206488_S_AT, 206171_AT, 202284_S_AT, 220066_AT, 228490_AT, 
               
               
                   
                 203665_AT, 205831_AT, 239519_AT, 203922_S_AT, 210145_AT, 206157_AT, 
               
               
                   
                 221815_AT, 225337_AT, 224341_X_AT, 203887_S_AT, 228766_AT, 1555755_A_AT, 
               
               
                   
                 209392_AT, 203060_S_AT, 201005_AT, 212464_S_AT, 237252_AT, 216442_X_AT, 
               
               
                   
                 63825_AT, 1405_I_AT, 221060_S_AT, 211719_X_AT, 205898_AT, 205099_S_AT, 
               
               
                   
                 211661_X_AT, 205566_AT, 207433_AT, 211026_S_AT, 235944_AT, 202827_S_AT, 
               
               
                   
                 208436_S_AT, 221463_AT, 87100_AT, 232068_S_AT, 235286_AT, 204465_S_AT, 
               
               
                   
                 209906_AT, 217757_AT, 210510_S_AT, 204655_AT, 1552553_A_AT, 1552798_A_AT, 
               
               
                   
                 237904_AT, 203888_AT, 208712_AT, 210004_AT, 1555759_A_AT, 241929_AT 
               
               
                 GO: 0002376~immune 
                 202869_AT, 205552_S_AT, 206206_AT, 222838_AT, 205798_AT, 203936_S_AT, 
               
               
                 system process 
                 220066_AT, 200878_AT, 202748_AT, 201565_S_AT, 221266_S_AT, 203922_S_AT, 
               
               
                   
                 229937_X_AT, 223502_S_AT, 215990_S_AT, 206157_AT, 201422_AT, 224341_X_AT, 
               
               
                   
                 206637_AT, 1555756_A_AT, 209392_AT, 242907_AT, 213293_S_AT, 214211_AT, 
               
               
                   
                 212171_X_AT, 1405_I_AT, 201566_X_AT, 221060_S_AT, 226218_AT, 223501_AT, 
               
               
                   
                 205099_S_AT, 211661_X_AT, 210895_S_AT, 222062_AT, 204116_AT, 207433_AT, 
               
               
                   
                 210146_X_AT, 210512_S_AT, 221463_AT, 205419_AT, 232068_S_AT, 211527_X_AT, 
               
               
                   
                 238581_AT, 235286_AT, 209906_AT, 203140_AT, 204655_AT, 210513_S_AT, 
               
               
                   
                 1552798_A_AT, 208978_AT, 213931_AT, 223434_AT, 210004_AT, 1555759_A_AT, 
               
               
                   
                 219434_AT, 202638_S_AT 
               
               
                 GO: 0050896~response 
                 210495_X_AT, 229221_AT, 202869_AT, 212298_AT, 209555_S_AT, 202435_S_AT, 
               
               
                 to stimulus 
                 223560_AT, 222838_AT, 205798_AT, 1563621_AT, 202284_S_AT, 242903_AT, 
               
               
                   
                 228490_AT, 201565_S_AT, 208922_S_AT, 229937_X_AT, 215990_S_AT, 221815_AT, 
               
               
                   
                 205495_S_AT, 228766_AT, 201005_AT, 203060_S_AT, 201242_S_AT, 242907_AT, 
               
               
                   
                 209122_AT, 213293_S_AT, 205128_X_AT, 214211_AT, 237252_AT, 212171_X_AT, 
               
               
                   
                 63825_AT, 202727_S_AT, 1405_I_AT, 221060_S_AT, 201566_X_AT, 211719_X_AT, 
               
               
                   
                 223501_AT, 205898_AT, 204058_AT, 205099_S_AT, 205566_AT, 207433_AT, 
               
               
                   
                 210146_X_AT, 235944_AT, 217678_AT, 209047_AT, 221463_AT, 232068_S_AT, 
               
               
                   
                 208436_S_AT, 238581_AT, 209906_AT, 1554992_AT, 243483_AT, 217757_AT, 
               
               
                   
                 204059_S_AT, 210510_S_AT, 210513_AT, 211676_S_AT, 238669_AT, 223434_AT, 
               
               
                   
                 225631_AT, 225097_AT, 205306_X_AT, 202638_S_AT, 201243_S_AT, 201069_AT, 
               
               
                   
                 205552_S_AT, 227948_AT, 206206_AT, 222877_AT, 202434_S_AT, 206488_S_AT, 
               
               
                   
                 206171_AT, 220066_AT, 200878_AT, 37145_AT, 205891_AT, 203665_AT, 
               
               
                   
                 202436_S_AT, 207542_S_AT, 214453_S_AT, 202748_AT, 239519_AT, 209921_AT, 
               
               
                   
                 210145_AT, 206157_AT, 223502_S_AT, 225337_AT, 220484_AT, 224341_X_AT, 
               
               
                   
                 203887_S_AT, 206637_AT, 211138_S_AT, 1555756_A_AT, 209332_AT, 209993_AT, 
               
               
                   
                 215813_S_AT, 212464_S_AT, 216442_X_AT, 202609_AT, 226218_AT, 218934_S_AT, 
               
               
                   
                 211661_X_AT, 210895_S_AT, 222062_AT, 204116_AT, 211026_S_AT, 210512_S_AT, 
               
               
                   
                 223092_AT, 202827_S_AT, 87100_AT, 205419_AT, 211527_X_AT, 235286_AT, 
               
               
                   
                 204465_S_AT, 203140_AT, 203980_AT, 204655_AT, 1552553_A_AT, 202437_S_AT, 
               
               
                   
                 230559_X_AT, 1552798_A_AT, 213931_AT, 203888_AT, 237904_AT, 208712_AT, 
               
               
                   
                 210004_AT, 229797_AT, 1555759_A_AT, 241929_AT, 219434_AT 
               
               
                 GO: 00322501~multicellular 
                 219358_S_AT, 220333_AT, 229221_AT, 212293_AT, 203555_S_AT, 202435_S_AT, 
               
               
                 organismal process 
                 221011_S_AT, 205798_AT, 228579_AT, 203936_S_AT, 242871_AT, 209348_S_AT, 
               
               
                   
                 230360_AT, 202284_S_AT, 227747_AT, 1569149_AT, 201565_S_AT, 201590_X_AT, 
               
               
                   
                 204653_AT, 204999_S_AT, 226066_AT, 215990_S_AT, 203104_AT, 200884_AT, 
               
               
                   
                 228766_AT, 243556_AT, 201005_AT, 203060_S_AT, 210095_S_AT, 205128_X_AT, 
               
               
                   
                 237252_AT, 214297_AT, 212171_X_AT, 221060_S_AT, 201566_X_AT, 228964_AT, 
               
               
                   
                 223596_AT, 218502_S_AT, 206835_AT, 207433_AT, 235944_AT, 222670_S_AT, 
               
               
                   
                 209047_AT, 232068_S_AT, 209906_AT, 1554992_AT, 243483_AT, 210510_S_AT, 
               
               
                   
                 210513_S_AT, 206675_S_AT, 238669_AT, 204105_S_AT, 212614_AT, 204881_S_AT, 
               
               
                   
                 225097_AT, 201069_AT, 224218_S_AT, 222877_AT, 202434_S_AT, 201278_AT, 
               
               
                   
                 206488_S_AT, 244375_AT, 211962_S_AT, 220066_AT, 200878_AT, 204141_AT, 
               
               
                   
                 205891_AT, 203665_AT, 202436_S_AT, 207542_S_AT, 201279_S_AT, 204998_S_AT, 
               
               
                   
                 208816_X_AT, 239519_AT, 221266_S_AT, 233540_S_AT, 210145_AT, 212190_AT, 
               
               
                   
                 212143_S_AT, 212086_X_AT, 220484_AT, 224341_X_AT, 203887_S_AT, 
               
               
                   
                 1555756_A_AT, 228762_AT, 222651_S_AT, 211986_AT, 213265_AT, 201324_AT, 
               
               
                   
                 215813_S_AT, 213503_X_AT, 204575_S_AT, 227240_AT, 210427_X_AT, 202609_AT, 
               
               
                   
                 214724_AT, 226218_AT, 244579_AT, 218559_S_AT, 211661_X_AT, 207233_S_AT, 
               
               
                   
                 204684_AT, 210512_S_AT, 223092_AT, 202827_S_AT, 205419_AT, 204475_AT, 
               
               
                   
                 211527_X_AT, 204465_S_AT, 203140_AT, 1560960_AT, 1569150_X_AT, 201952_AT, 
               
               
                   
                 203980_AT, 220935_S_AT, 1552553_A_AT, 202437_S_AT, 1552798_A_AT, 
               
               
                   
                 208978_AT, 213931_AT, 203888_AT, 208712_AT, 210757_X_AT, 222876_S_AT, 
               
               
                   
                 210004_AT, 229797_AT, 201280_S_AT, 241929_AT, 201951_AT 
               
               
                 GO: 0050793~regulation 
                 210495_X_AT, 212298_AT, 209555_S_AT, 227948_AT, 205798_AT, 206488_S_AT, 
               
               
                 of developmental 
                 214255_AT, 209348_S_AT, 1569149_AT, 203665_AT, 205891_AT, 204998_S_AT, 
               
               
                 process 
                 201565_S_AT, 239519_AT, 233540_S_AT, 204999_S_AT, 226066_AT, 210145_AT, 
               
               
                   
                 215990_S_AT, 212143_S_AT, 215602_AT, 224341_X_AT, 228766_AT, 210095_S_AT, 
               
               
                   
                 212464_S_AT, 216442_X_AT, 212171_X_AT, 1553906_S_AT, 1405_I_AT, 
               
               
                   
                 201566_X_AT, 221060_S_AT, 211719_X_AT, 226218_AT, 218559_S_AT, 
               
               
                   
                 207233_S_AT, 210895_S_AT, 206835_AT, 222062_AT, 204116_AT, 207433_AT, 
               
               
                   
                 210512_S_AT, 223092_AT, 222670_S_AT, 232068_S_AT, 211527_X_AT, 203140_AT, 
               
               
                   
                 1569150_X_AT, 220935_S_AT, 210510_S_AT, 204655_AT, 210513_S_AT, 
               
               
                   
                 230559_X_AT, 1565754_X_AT, 1552798_A_AT, 213931_AT, 1565752_AT, 
               
               
                   
                 208712_AT, 204105_S_AT, 1555759_A_AT, 1556423_AT, 241929_AT 
               
               
                 GO: 0009897~external 
                 229221_AT, 243483_AT, 214297_AT, 201952_AT, 220307_AT, 221060_S_AT, 
               
               
                 side of plasma 
                 1552798_A_AT, 226218_AT, 205798_AT, 204105_S_AT, 210895_S_AT, 204116_AT, 
               
               
                 membrane 
                 224341_X_AT, 202756_S_AT, 1555756_A_AT, 232068_S_AT, 201951_AT, 
               
               
                   
                 202638_S_AT 
               
               
                 GO: 0051239~regulation 
                 212298_AT, 223660_AT, 205798_AT, 206171_AT, 209348_S_AT, 220066_AT, 
               
               
                 of multicellular 
                 200878_AT, 1569149_AT, 203665_AT, 205891_AT, 204998_S_AT, 208816_X_AT, 
               
               
                 organismal process 
                 201565_S_AT, 239519_AT, 201590_X_AT, 233540_S_AT, 204999_S_AT, 226066_AT, 
               
               
                   
                 210145_AT, 215990_S_AT, 212143_S_AT, 224341_X_AT, 1555756_A_AT, 
               
               
                   
                 215813_S_AT, 210095_S_AT, 205128_X_AT, 212171_X_AT, 213503_X_AT, 
               
               
                   
                 1405_I_AT, 201566_X_AT, 210427_X_AT, 221060_S_AT, 226218_AT, 218934_S_AT, 
               
               
                   
                 218559_S_AT, 207233_S_AT, 210895_S_AT, 206835_AT, 222062_AT, 204116_AT, 
               
               
                   
                 207433_AT, 210512_S_AT, 223092_AT, 222670_S_AT, 232068_S_AT, 211527_X_AT, 
               
               
                   
                 1554992_AT, 203140_AT, 1569150_X_AT, 220935_S_AT, 210510_S_AT, 204655_AT, 
               
               
                   
                 210513_S_AT, 1552798_A_AT, 213931_AT, 238669_AT, 237904_AT, 204105_S_AT, 
               
               
                   
                 208712_AT, 1555759_A_AT, 1556423_AT 
               
               
                 GO: 0006952~defense 
                 229221_AT, 216442_X_AT, 210495_X_AT, 223660_AT, 1405_I_AT, 221060_S_AT, 
               
               
                 response 
                 206206_AT, 211719_X_AT, 222838_AT, 205898_AT, 205099_S_AT, 211661_X_AT, 
               
               
                   
                 222062_AT, 206171_AT, 207433_AT, 211026_S_AT, 210146_X_AT, 208436_S_AT, 
               
               
                   
                 232068_S_AT, 221463_AT, 220066_AT, 37145_AT, 209906_AT, 203665_AT, 
               
               
                   
                 205891_AT, 217757_AT, 204655_AT, 1552553_A_AT, 1552798_A_AT, 203922_S_AT, 
               
               
                   
                 206157_AT, 237904_AT, 210004_AT, 224341_X_AT, 205495_S_AT, 1555756_A_AT, 
               
               
                   
                 1555759_A_AT, 212464_S_AT 
               
               
                 GO: 0006954~inflammatory 
                 210495_X_AT, 216442_X_AT, 229221_AT, 223660_AT, 1405_I_AT, 206206_AT, 
               
               
                 response 
                 221060_S_AT, 211719_X_AT, 205099_S_AT, 211661_X_AT, 211026_S_AT, 
               
               
                   
                 206171_AT, 207433_AT, 232068_S_AT, 221463_AT, 208436_S_AT, 209906_AT, 
               
               
                   
                 203665_AT, 217757_AT, 204655_AT, 1552553_A_AT, 1552798_A_AT, 203922_S_AT, 
               
               
                   
                 206157_AT, 237904_AT, 224341_X_AT, 210004_AT, 1555756_A_AT, 1555759_A_AT, 
               
               
                   
                 212464_S_AT 
               
               
                 GO: 0031012~extracellular 
                 229221_AT, 216442_X_AT, 210495_X_AT, 201069_AT, 213428_S_AT, 212171_X_AT, 
               
               
                 matrix 
                 213503_X_AT, 204575_S_AT, 208816_X_AT, 229004_AT, 210513_S_AT, 
               
               
                   
                 210427_X_AT, 201590_X_AT, 211719_X_AT, 202756_S_AT, 228873_AT, 
               
               
                   
                 203936_S_AT, 235944_AT, 210512_S_AT, 202827_S_AT, 211527_X_AT, 204475_AT, 
               
               
                   
                 212464_S_AT 
               
               
                 GO: 0048583~regulation 
                 1553995_A_AT, 212171_X_AT, 213503_X_AT, 227948_AT, 1405_I_AT, 
               
               
                 of response to stimulus 
                 210427_X_AT, 221060_S_AT, 226218_AT, 223501_AT, 205798_AT, 210895_S_AT, 
               
               
                   
                 222062_AT, 207433_AT, 210512_S_AT, 220066_AT, 232068_S_AT, 208436_S_AT, 
               
               
                   
                 211527_X_AT, 203939_AT, 209906_AT, 203665_AT, 205891_AT, 203140_AT, 
               
               
                   
                 217757_AT, 203980_AT, 208816_X_AT, 204655_AT, 210513_S_AT, 230559_X_AT, 
               
               
                   
                 201590_X_AT, 1552798_A_AT, 210145_AT, 223502_S_AT, 215990_S_AT, 
               
               
                   
                 224341_X_AT, 225097_AT, 1555756_A_AT, 1555759_A_AT, 202638_S_AT 
               
               
                 GO: 0005578~proteinaceous 
                 216442_X_AT, 210495_X_AT, 201069_AT, 213428_S_AT, 212171_X_AT, 
               
               
                 extracellular matrix 
                 213503_X_AT, 204575_S_AT, 208816_X_AT, 229004_AT, 210513_S_AT, 
               
               
                   
                 210427_X_AT, 201590_X_AT, 211719_X_AT, 202756_S_AT, 228873_AT, 
               
               
                   
                 203936_S_AT, 235944_AT, 210512_S_AT, 202827_S_AT, 211527_X_AT, 204475_AT, 
               
               
                   
                 212464_S_AT 
               
               
                 GO: 0009986~cell surface 
                 229221_AT, 214297_AT, 212171_X_AT, 209555_S_AT, 221060_S_AT, 226218_AT, 
               
               
                   
                 205798_AT, 206488_S_AT, 210895_S_AT, 204116_AT, 210512_S_AT, 220066_AT, 
               
               
                   
                 232068_S_AT, 211527_X_AT, 243483_AT, 201952_AT, 220307_AT, 210513_S_AT, 
               
               
                   
                 221266_S_AT, 1552798_A_AT, 204105_S_AT, 224341_X_AT, 202756_S_AT, 
               
               
                   
                 228766_AT, 1555756_A_AT, 241929_AT, 209993_AT, 201951_AT, 202638_S_AT 
               
               
                 GO: 0002682~regulation 
                 229221_AT, 212171_X_AT, 1405_I_AT, 201566_X_AT, 221060_S_AT, 226218_AT, 
               
               
                 of immune system 
                 223501_AT, 218559_S_AT, 205798_AT, 207233_S_AT, 210895_S_AT, 222062_AT, 
               
               
                 process 
                 204116_AT, 207433_AT, 210512_S_AT, 202284_S_AT, 222670_S_AT, 220066_AT, 
               
               
                   
                 232068_S_AT, 211527_X_AT, 209906_AT, 203665_AT, 205891_AT, 203140_AT, 
               
               
                   
                 217757_AT, 204655_AT, 210513_S_AT, 201565_S_AT, 1552798_A_AT, 226066_AT, 
               
               
                   
                 223502_S_AT, 213931_AT, 215990_S_AT, 224341_X_AT, 1555756_A_AT, 
               
               
                   
                 1555759_A_AT, 202638_S_AT 
               
               
                 GO: 0005615~extracellular 
                 237252_AT, 210495_X_AT, 216442_X_AT, 201069_AT, 212171_X_AT, 1405_I_AT, 
               
               
                 space 
                 211719_X_AT, 223501_AT, 229900_AT, 207433_AT, 227265_AT, 203936_S_AT, 
               
               
                   
                 210512_S_AT, 226545_AT, 221463_AT, 211527_X_AT, 235286_AT, 37145_AT, 
               
               
                   
                 203665_AT, 217757_AT, 204655_AT, 210513_S_AT, 212190_AT, 223502_S_AT, 
               
               
                   
                 212143_S_AT, 203888_AT, 203887_S_AT, 202756_S_AT, 205495_S_AT, 204834_AT, 
               
               
                   
                 1555759_A_AT, 1556423_AT, 210095_S_AT, 202638_S_AT, 212464_S_AT 
               
               
                 GO: 0048731~system 
                 219358_S_AT, 229221_AT, 201069_AT, 212298_AT, 224218_S_AT, 222877_AT, 
               
               
                 development 
                 205798_AT, 244375_AT, 211962_S_AT, 209348_S_AT, 203936_S_AT, 202284_S_AT, 
               
               
                   
                 230360_AT, 200878_AT, 204141_AT, 1569149_AT, 203665_AT, 204998_S_AT, 
               
               
                   
                 206816_X_AT, 201565_S_AT, 239519_AT, 201590_X_AT, 221266_S_AT, 
               
               
                   
                 233540_S_AT, 204999_S_AT, 204653_AT, 210145_AT, 226066_AT, 212190_AT, 
               
               
                   
                 215990_S_AT, 212143_S_AT, 212086_X_AT, 220484_AT, 200884_AT, 228762_AT, 
               
               
                   
                 243556_AT, 203060_S_AT, 201005_AT, 222651_S_AT, 211986_AT, 210095_S_AT, 
               
               
                   
                 201324_AT, 213503_X_AT, 214297_AT, 212171_X_AT, 204575_S_AT, 227240_AT, 
               
               
                   
                 201566_X_AT, 210427_X_AT, 228964_AT, 226218_AT, 244579_AT, 218559_S_AT, 
               
               
                   
                 207233_S_AT, 206835_AT, 218502_S_AT, 204684_AT, 207433_AT, 202827_S_AT, 
               
               
                   
                 223092_AT, 222670_S_AT, 210512_S_AT, 205419_AT, 211527_X_AT, 204465_S_AT, 
               
               
                   
                 1554992_AT, 203140_AT, 1560960_AT, 1569150_X_AT, 201952_AT, 220935_S_AT, 
               
               
                   
                 210510_S_AT, 210513_S_AT, 208978_AT, 213931_AT, 204105_S_AT, 208712_AT, 
               
               
                   
                 212614_AT, 204881_S_AT, 222876_S_AT, 229797_AT, 201951_AT 
               
               
                 GO: 0051707~response 
                 237252_AT, 1405_I_AT, 202727_S_AT, 221060_S_AT, 211661_X_AT, 222062_AT, 
               
               
                 to other organism 
                 207433_AT, 232068_S_AT, 220066_AT, 208436_S_AT, 242903_AT, 37145_AT, 
               
               
                   
                 214453_S_AT, 204655_AT, 1552553_A_AT, 1552798_A_AT, 211676_S_AT, 
               
               
                   
                 229937_X_AT, 210145_AT, 206157_AT, 203888_AT, 224341_X_AT, 203887_S_AT, 
               
               
                   
                 205495_S_AT, 1555756_A_AT, 1555759_A_AT, 213293_S_AT 
               
               
                 GO: 0007275~multicellular 
                 220333_AT, 219358_S_AT, 229221_AT, 201069_AT, 212298_AT, 224218_S_AT, 
               
               
                 organismal 
                 221011_S_AT, 222877_AT, 201278_AT, 205798_AT, 244375_AT, 211962_S_AT, 
               
               
                 development 
                 209348_S_AT, 242871_AT, 203936_S_AT, 202284_S_AT, 230360_AT, 200878_AT, 
               
               
                   
                 204141_AT, 1569149_AT, 203665_AT, 201279_S_AT, 204998_S_AT, 206816_X_AT, 
               
               
                   
                 201565_S_AT, 239519_AT, 201590_X_AT, 221266_S_AT, 233540_S_AT, 
               
               
                   
                 204999_S_AT, 204653_AT, 210145_AT, 226066_AT, 212190_AT, 215990_S_AT, 
               
               
                   
                 212143_S_AT, 203104_AT, 212086_X_AT, 220484_AT, 200884_AT, 203887_S_AT, 
               
               
                   
                 228762_AT, 243556_AT, 203060_S_AT, 201005_AT, 222651_S_AT, 211986_AT, 
               
               
                   
                 210095_S_AT, 201324_AT, 237252_AT, 212171_X_AT, 213503_X_AT, 214297_AT, 
               
               
                   
                 204575_S_AT, 227240_AT, 201566_X_AT, 210427_X_AT, 228964_AT, 214724_AT, 
               
               
                   
                 226218_AT, 244579_AT, 218559_S_AT, 207233_S_AT, 206835_AT, 218502_S_AT, 
               
               
                   
                 204684_AT, 207433_AT, 202827_S_AT, 223092_AT, 210512_S_AT, 222670_S_AT, 
               
               
                   
                 205419_AT, 211527_X_AT, 204465_S_AT, 1554992_AT, 203140_AT, 1560960_AT, 
               
               
                   
                 1569150_X_AT, 201952_AT, 220935_S_AT, 210510_S_AT, 210513_S_AT, 
               
               
                   
                 208978_AT, 206675_S_AT, 213931_AT, 203888_AT, 204105_S_AT, 208712_AT, 
               
               
                   
                 212614_AT, 204881_S_AT, 210757_X_AT, 222876_S_AT, 225097_AT, 229797_AT, 
               
               
                   
                 201280_S_AT, 201951_AT 
               
               
                 GO: 0032101~regulation 
                 1553995_A_AT, 205891_AT, 203140_AT, 212171_X_AT, 213503_X_AT, 217757_AT, 
               
               
                 of response to external 
                 203980_AT, 208816_X_AT, 1405_I_AT, 204655_AT, 210513_S_AT, 221060_S_AT, 
               
               
                 stimulus 
                 210427_X_AT, 201590_X_AT, 1552798_A_AT, 210145_AT, 215990_S_AT, 
               
               
                   
                 224341_X_AT, 207433_AT, 210512_S_AT, 1555759_A_AT, 232068_S_AT, 
               
               
                   
                 211527_X_AT, 203939_AT 
               
               
                 GO: 0022610~biological 
                 229221_AT, 210495_X_AT, 216442_X_AT, 212298_AT, 209555_S_AT, 1405_I_AT, 
               
               
                 adhesion 
                 211719_X_AT, 222838_AT, 210360_S_AT, 222877_AT, 211066_X_AT, 205898_AT, 
               
               
                   
                 205099_S_AT, 206488_S_AT, 215836_S_AT, 225188_AT, 228640_AT, 227747_AT, 
               
               
                   
                 213428_S_AT, 201952_AT, 204655_AT, 210510_S_AT, 225189_S_AT, 239519_AT, 
               
               
                   
                 203037_S_AT, 205718_AT, 216250_S_AT, 204105_S_AT, 210004_AT, 228766_AT, 
               
               
                   
                 1555756_A_AT, 228873_AT, 1555759_A_AT, 241929_AT, 201125_S_AT, 201005_AT, 
               
               
                   
                 201951_AT, 202638_S_AT, 212464_S_AT 
               
               
                 GO: 0007155~cell 
                 229221_AT, 210495_X_AT, 216442_X_AT, 212298_AT, 209555_S_AT, 1405_I_AT, 
               
               
                 adhesion 
                 211719_X_AT, 222838_AT, 210360_S_AT, 222877_AT, 211066_X_AT, 205898_AT, 
               
               
                   
                 205099_S_AT, 206488_S_AT, 215836_S_AT, 225188_AT, 228640_AT, 227747_AT, 
               
               
                   
                 213428_S_AT, 201952_AT, 204655_AT, 210510_S_AT, 225189_S_AT, 239519_AT, 
               
               
                   
                 203037_S_AT, 205718_AT, 216250_S_AT, 204105_S_AT, 210004_AT, 228766_AT, 
               
               
                   
                 1555756_A_AT, 228873_AT, 1555759_A_AT, 241929_AT, 201125_S_AT, 201005_AT, 
               
               
                   
                 201951_AT, 202638_S_AT, 212464_S_AT 
               
               
                 GO: 0048856~anatomical 
                 219358_S_AT, 210495_X_AT, 229221_AT, 201069_AT, 212238_AT, 224218_S_AT, 
               
               
                 structure development 
                 222877_AT, 201278_AT, 205798_AT, 244375_AT, 211962_S_AT, 209348_S_AT, 
               
               
                   
                 203936_S_AT, 202284_S_AT, 230360_AT, 200878_AT, 204141_AT, 1569149_AT, 
               
               
                   
                 203665_AT, 201279_S_AT, 204998_S_AT, 208816_X_AT, 201565_S_AT, 239519_AT, 
               
               
                   
                 201590_X_AT, 221266_S_AT, 233540_S_AT, 204999_S_AT, 204653_AT, 210145_AT, 
               
               
                   
                 226066_AT, 212190_AT, 215990_S_AT, 212143_S_AT, 212086_X_AT, 220484_AT, 
               
               
                   
                 200884_AT, 228762_AT, 243556_AT, 203060_S_AT, 201005_AT, 222651_S_AT, 
               
               
                   
                 211986_AT, 210095_S_AT, 201324_AT, 212464_S_AT, 216442_X_AT, 213503_X_AT, 
               
               
                   
                 214297_AT, 212171_X_AT, 204575_S_AT, 227240_AT, 201566_X_AT, 210427_X_AT, 
               
               
                   
                 228964_AT, 211719_X_AT, 226218_AT, 244579_AT, 218559_S_AT, 207233_S_AT, 
               
               
                   
                 206835_AT, 218502_S_AT, 204684_AT, 207433_AT, 202827_S_AT, 223092_AT, 
               
               
                   
                 222670_S_AT, 210512_S_AT, 205419_AT, 211527_X_AT, 204465_S_AT, 
               
               
                   
                 1554992_AT, 203140_AT, 1560960_AT, 1569150_X_AT, 201952_AT, 220935_S_AT, 
               
               
                   
                 210510_S_AT, 210513_S_AT, 208978_AT, 213931_AT, 204105_S_AT, 208712_AT, 
               
               
                   
                 212614_AT, 204881_S_AT, 210757_X_AT, 222876_S_AT, 229797_AT, 201280_S_AT, 
               
               
                   
                 201951_AT 
               
               
                 GO: 0065008~regulation 
                 223723_AT, 210495_X_AT, 212298_AT, 209555_S_AT, 202435_S_AT, 227948_AT, 
               
               
                 of biological quality 
                 205798_AT, 201278_AT, 202434_S_AT, 206488_S_AT, 214255_AT, 202284_S_AT, 
               
               
                   
                 200878_AT, 203665_AT, 205891_AT, 202436_S_AT, 201279_S_AT, 208816_X_AT, 
               
               
                   
                 201565_S_AT, 239519_AT, 201590_X_AT, 210145_AT, 223502_S_AT, 215990_S_AT, 
               
               
                   
                 200884_AT, 215602_AT, 203887_S_AT, 224341_X_AT, 201422_AT, 228766_AT, 
               
               
                   
                 203060_S_AT, 201005_AT, 215813_S_AT, 201324_AT, 205128_X_AT, 212464_S_AT, 
               
               
                   
                 214211_AT, 237252_AT, 216442_X_AT, 212171_X_AT, 213503_X_AT, 
               
               
                   
                 1553906_S_AT, 1405_I_AT, 221060_S_AT, 201566_X_AT, 210427_X_AT, 
               
               
                   
                 211719_X_AT, 223596_AT, 226218_AT, 223501_AT, 34210_AT, 204661_AT, 
               
               
                   
                 205099_S_AT, 206835_AT, 207433_AT, 235944_AT, 210512_S_AT, 208436_S_AT, 
               
               
                   
                 232068_S_AT, 211527_X_AT, 209906_AT, 1554992_AT, 203140_AT, 243483_AT, 
               
               
                   
                 203980_AT, 204655_AT, 210510_S_AT, 210513_S_AT, 202437_S_AT, 230559_X_AT, 
               
               
                   
                 1565754_X_AT, 1552738_A_AT, 213931_AT, 203888_AT, 238669_AT, 1565752_AT, 
               
               
                   
                 210757_X_AT, 1555759_A_AT, 241929_AT, 201280_S_AT, 223394_AT 
               
               
                 GO: 0007166~cell surface 
                 212298_AT, 223660_AT, 210360_S_AT, 242794_AT, 205798_AT, 244375_AT, 
               
               
                 receptor linked signal 
                 206171_AT, 232333_AT, 218589_AT, 205891_AT, 207610_S_AT, 239519_AT, 
               
               
                 transduction 
                 234645_AT, 226066_AT, 203104_AT, 212977_AT, 223939_AT, 206637_AT, 
               
               
                   
                 1555756_A_AT, 209392_AT, 212171_X_AT, 1405_I_AT, 235457_AT, 202609_AT, 
               
               
                   
                 214724_AT, 226218_AT, 205838_AT, 205099_S_AT, 211661_X_AT, 207233_S_AT, 
               
               
                   
                 222062_AT, 232746_AT, 210146_X_AT, 210512_S_AT, 205419_AT, 211527_X_AT, 
               
               
                   
                 244414_AT, 209906_AT, 242405_AT, 210510_S_AT, 204655_AT, 210513_S_AT, 
               
               
                   
                 214054_AT, 203037_S_AT, 210264_AT, 205718_AT, 237904_AT, 208712_AT, 
               
               
                   
                 212614_AT, 210258_AT, 206134_AT, 225097_AT, 1555759_A_AT, 201125_S_AT 
               
               
                 GO: 0050727~regulation 
                 1553995_A_AT, 203140_AT, 205891_AT, 217757_AT, 203980_AT, 1405_I_AT, 
               
               
                 of inflammatory 
                 204655_AT, 221060_S_AT, 1552798_A_AT, 210145_AT, 215990_S_AT, 
               
               
                 response 
                 224341_X_AT, 207433_AT, 1555759_A_AT, 232068_S_AT, 203939_AT 
               
               
                 GO: 0006950~response 
                 210495_X_AT, 229221_AT, 201069_AT, 212298_AT, 209555_S_AT, 227948_AT, 
               
               
                 to stress 
                 223660_AT, 206206_AT, 222838_AT, 206488_S_AT, 206171_AT, 202284_S_AT, 
               
               
                   
                 1563621_AT, 220066_AT, 200878_AT, 37145_AT, 228490_AT, 203665_AT, 
               
               
                   
                 205891_AT, 239519_AT, 203922_S_AT, 210145_AT, 215990_S_AT, 221815_AT, 
               
               
                   
                 206157_AT, 225337_AT, 224341_X_AT, 203887_S_AT, 205495_S_AT, 228766_AT, 
               
               
                   
                 211138_S_AT, 1555756_A_AT, 201005_AT, 203060_S_AT, 201242_S_AT, 
               
               
                   
                 215813_S_AT, 212464_S_AT, 205128_X_AT, 237252_AT, 216442_X_AT, 
               
               
                   
                 212171_X_AT, 63825_AT, 1405_I_AT, 221060_S_AT, 211719_X_AT, 218934_S_AT, 
               
               
                   
                 205898_AT, 205099_S_AT, 211661_X_AT, 205566_AT, 222062_AT, 211026_S_AT, 
               
               
                   
                 207433_AT, 210146_X_AT, 235944_AT, 202827_S_AT, 210512_S_AT, 221463_AT, 
               
               
                   
                 87100_AT, 232068_S_AT, 208436_S_AT, 211527_X_AT, 204465_S_AT, 209906_AT, 
               
               
                   
                 203140_AT, 243483_AT, 217757_AT, 210510_S_AT, 204655_AT, 1552553_A_AT, 
               
               
                   
                 230559_X_AT, 210513_S_AT, 1552798_A_AT, 238669_AT, 203888_AT, 237904_AT, 
               
               
                   
                 208712_AT, 210004_AT, 225631_AT, 225097_AT, 205306_X_AT, 1555759_A_AT, 
               
               
                   
                 241929_AT, 201243_S_AT 
               
               
                 GO: 0032502~developmental 
                 219358_S_AT, 220333_AT, 229221_AT, 210495_X_AT, 212298_AT, 221011_S_AT, 
               
               
                 process 
                 205798_AT, 203936_S_AT, 242871_AT, 209348_S_AT, 230360_AT, 202284_S_AT, 
               
               
                   
                 1569149_AT, 201565_S_AT, 201590_X_AT, 204653_AT, 204999_S_AT, 226066_AT, 
               
               
                   
                 215990_S_AT, 203104_AT, 200884_AT, 243556_AT, 201005_AT, 203060_S_AT, 
               
               
                   
                 210095_S_AT, 205128_X_AT, 237252_AT, 214297_AT, 212171_X_AT, 1405_I_AT, 
               
               
                   
                 201566_X_AT, 211719_X_AT, 228964_AT, 218502_S_AT, 206835_AT, 207433_AT, 
               
               
                   
                 222670_S_AT, 1554992_AT, 210510_S_AT, 210513_S_AT, 206675_S_AT, 
               
               
                   
                 238669_AT, 212614_AT, 204105_S_AT, 204881_S_AT, 225097_AT, 201069_AT, 
               
               
                   
                 224218_S_AT, 222877_AT, 201278_AT, 244375_AT, 211962_S_AT, 200878_AT, 
               
               
                   
                 204141_AT, 203665_AT, 201279_S_AT, 204998_S_AT, 208816_X_AT, 239519_AT, 
               
               
                   
                 221266_S_AT, 233540_S_AT, 212190_AT, 210145_AT, 212143_S_AT, 212086_X_AT, 
               
               
                   
                 220484_AT, 203887_S_AT, 228762_AT, 222651_S_AT, 211986_AT, 201324_AT, 
               
               
                   
                 215813_S_AT, 212464_S_AT, 216442_X_AT, 213503_X_AT, 204575_S_AT, 
               
               
                   
                 227240_AT, 210427_X_AT, 214724_AT, 226218_AT, 244579_AT, 218559_S_AT, 
               
               
                   
                 207233_S_AT, 204684_AT, 210512_S_AT, 223092_AT, 202827_S_AT, 205419_AT, 
               
               
                   
                 211527_X_AT, 204465_S_AT, 203140_AT, 1560960_AT, 1569150_X_AT, 201952_AT, 
               
               
                   
                 203980_AT, 220935_S_AT, 204655_AT, 208978_AT, 213931_AT, 203888_AT, 
               
               
                   
                 208712_AT, 222876_S_AT, 210757_X_AT, 229797_AT, 1555759_A_AT, 
               
               
                   
                 201280_S_AT, 201951_AT 
               
               
                 GO: 0031347~regulation 
                 1553995_A_AT, 205891_AT, 203140_AT, 217757_AT, 203980_AT, 1405_I_AT, 
               
               
                 of defense response 
                 204655_AT, 221060_S_AT, 1552798_A_AT, 210145_AT, 215990_S_AT, 
               
               
                   
                 224341_X_AT, 207433_AT, 1555756_A_AT, 1555759_A_AT, 232068_S_AT, 
               
               
                   
                 208436_S_AT, 220066_AT, 203939_AT 
               
               
                 GO: 0009607~response 
                 237252_AT, 1405_I_AT, 202727_S_AT, 221060_S_AT, 218934_S_AT, 211661_X_AT, 
               
               
                 to biotic stimulus 
                 222062_AT, 207433_AT, 232068_S_AT, 220066_AT, 208436_S_AT, 242903_AT, 
               
               
                   
                 37145_AT, 214453_S_AT, 204655_AT, 1552553_A_AT, 211676_S_AT, 
               
               
                   
                 1552798_A_AT, 229937_X_AT, 210145_AT, 20615_AT, 203888_AT, 208712_AT, 
               
               
                   
                 224341_X_AT, 203887_S_AT, 205495_S_AT, 1555756_A_AT, 1555759_A_AT, 
               
               
                   
                 213293_S_AT 
               
               
                 GO: 0019955~cytokine 
                 204912_AT, 209555_S_AT, 217757_AT, 202727_S_AT, 226218_AT, 211676_S_AT, 
               
               
                 binding 
                 205898_S_AT, 205099_S_AT, 205798_AT, 203104_AT, 206488_S_AT, 222062_AT, 
               
               
                   
                 204116_AT, 228766_AT, 241929_AT, 242903_AT 
               
               
                 GO: 0050776~regulation 
                 209906_AT, 203665_AT, 205891_AT, 203140_AT, 217757_AT, 221060_S_AT, 
               
               
                 of immune response 
                 1552798_A_AT, 226218_AT, 223501_AT, 223502_S_AT, 215590_S_AT, 205798_AT, 
               
               
                   
                 210895_S_AT, 222062_AT, 224341_X_AT, 207433_AT, 1555756_A_AT, 220066_AT, 
               
               
                   
                 232068_S_AT, 202638_S_AT 
               
               
                 GO: 0040011~locomotion 
                 210495_X_AT, 216442_X_AT, 229221_AT, 212298_AT, 1405_I_AT, 211719_X_AT, 
               
               
                   
                 222877_AT, 205898_AT, 204268_AT, 205099_S_AT, 211661_X_AT, 207433_AT, 
               
               
                   
                 202827_S_AT, 221463_AT, 235286_AT, 209906_AT, 1560960_AT, 204655_AT, 
               
               
                   
                 210510_S_AT, 239519_AT, 212614_AT, 204105_S_AT, 1555759_A_AT, 209392_AT, 
               
               
                   
                 202638_S_AT, 212464_S_AT 
               
               
                 GO: 0080134~regulation 
                 1553995_A_AT, 213503_X_AT, 227948_AT, 1405_I_AT, 210427_X_AT, 
               
               
                 of response to stress 
                 221060_S_AT, 207433_AT, 220066_AT, 232068_S_AT, 208436_S_AT, 203939_AT, 
               
               
                   
                 203140_AT, 205891_AT, 217757_AT, 203980_AT, 208816_X_AT, 204655_AT, 
               
               
                   
                 230559_X_AT, 201590_X_AT, 1552798_A_AT, 210145_AT, 215990_S_AT, 
               
               
                   
                 224341_X_AT, 225097_AT, 155575_A_AT, 1555759_A_AT 
               
               
                 GO: 0007626~locomotory 
                 209906_AT, 1405_I_AT, 204655_AT, 202609_AT, 222877_AT, 205898_AT, 
               
               
                 behavior 
                 205099_S_AT, 211661_X_AT, 220484_AT, 225097_AT, 207433_AT, 229797_AT, 
               
               
                   
                 223092_AT, 1555759_A_AT, 209392_AT, 221463_AT, 235286_AT 
               
               
                 GO: 0002684~positive 
                 209906_AT, 205891_AT, 203140_AT, 212171_X_AT, 210513_S_AT, 221060_S_AT, 
               
               
                 regulation of immune 
                 226218_AT, 1552798_A_AT, 223501_AT, 223502_S_AT, 215990_S_AT, 205798_AT, 
               
               
                 system process 
                 210895_S_AT, 222062_AT, 204116_AT, 224341_X_AT, 1555756_A_AT, 
               
               
                   
                 210512_S_AT, 202284_S_AT, 220066_AT, 232068_S_AT, 211527_X_AT, 
               
               
                   
                 202638_S_AT 
               
               
                 GO: 0000267~cell 
                 1553995_A_AT, 202869_AT, 209555_S_AT, 202435_S_AT, 205552_S_AT, 
               
               
                 fraction 
                 227134_AT, 211066_X_AT, 222877_AT, 219412_AT, 202434_S_AT, 206488_S_AT, 
               
               
                   
                 208789_AT, 203939_AT, 203665_AT, 202436_S_AT, 216080_S_AT, 201590_X_AT, 
               
               
                   
                 208161_S_AT, 210145_AT, 223502_S_AT, 236345_AT, 1557938_S_AT, 
               
               
                   
                 212086_X_AT, 228766_AT, 209993_AT, 201324_AT, 215813_S_AT, 205128_X_AT, 
               
               
                   
                 213503_X_AT, 1405_I_AT, 210427_X_AT, 202609_AT, 223596_AT, 223501_AT, 
               
               
                   
                 204058_AT, 34210_AT, 204461_AT, 218613_AT, 210146_X_AT, 215836_S_AT, 
               
               
                   
                 1554992_AT, 204059_S_AT, 203980_AT, 204655_AT, 202437_S_AT, 238669_AT, 
               
               
                   
                 204257_AT, 204811_S_AT, 210004_AT, 202087_S_AT, 1555759_A_AT, 241929_AT, 
               
               
                   
                 203355_S_AT 
               
               
                 GO: 0045028~purinergic 
                 218589_AT, 205891_AT, 223939_AT, 206637_AT, 223660_AT, 206171_AT, 
               
               
                 nudeotide receptor 
                 205419_AT, 237904_AT 
               
               
                 activity, G-protein 
               
               
                 coupled 
               
               
                 GO: 0001608~nucleotide 
                 218589_AT, 205891_AT, 223939_AT, 206637_AT, 223660_AT, 206171_AT, 
               
               
                 receptor activity, G- 
                 205419_AT, 237904_AT 
               
               
                 protein coupled 
               
               
                 GO: 0004930~G-protein 
                 218589_AT, 209906_AT, 205891_AT, 207610_S_AT, 223660_AT, 210264_AT, 
               
               
                 coupled receptor activity 
                 205898_AT, 205099_S_AT, 211661_X_AT, 237904_AT, 212977_AT, 232746_AT, 
               
               
                   
                 223939_AT, 206637_AT, 206171_AT, 205419_AT 
               
               
                 GO: 0016502~nucleotide 
                 218589_AT, 205891_AT, 223939_AT, 206637_AT, 223660_AT, 206171_AT, 
               
               
                 receptor activity 
                 205419_AT, 237904_AT 
               
               
                 GO: 0001614~purinergic 
                 218589_AT, 205891_AT, 223939_AT, 206637_AT, 223660_AT, 206171_AT, 
               
               
                 nucleotide receptor 
                 205419_AT, 237904_AT 
               
               
                 GO: 0005626~insoluble 
                 1553995_A_AT, 202869_AT, 209555_S_AT, 205552_S_AT, 202435_S_AT, 
               
               
                 friction 
                 202609_AT, 223596_AT, 222877_AT, 227134_AT, 211066_X_AT, 204661_AT, 
               
               
                   
                 34210_AT, 219412_AT, 202434_S_AT, 218613_AT, 206488_S_AT, 210146_X_AT, 
               
               
                   
                 215836_S_AT, 208789_AT, 203939_AT, 1554992_AT, 203665_AT, 202436_S_AT, 
               
               
                   
                 202437_S_AT, 216080_S_AT, 208161_S_AT, 210145_AT, 1557938_S_AT, 
               
               
                   
                 236345_AT, 238669_AT, 204257_AT, 212086_X_AT, 204881_S_AT, 210004_AT, 
               
               
                   
                 228766_AT, 241929_AT, 203355_S_AT, 209993_AT, 215813_S_AT, 201324_AT, 
               
               
                   
                 205128_X_AT 
               
               
                 GO: 0048513~organ 
                 219358_S_AT, 229221_AT, 201069_AT, 212298_AT, 222877_AT, 205798_AT, 
               
               
                 development 
                 244375_AT, 211962_S_AT, 203936_S_AT, 209348_S_AT, 202284_S_AT, 200878_AT, 
               
               
                   
                 203665_AT, 208816_K_AT, 239519_AT, 201565_S_AT, 201590_X_AT, 221266_S_AT, 
               
               
                   
                 233540_S_AT, 204653_AT, 226066_AT, 210145_AT, 215990_S_AT, 212086_X_AT, 
               
               
                   
                 220484_AT, 200884_AT, 228762_AT, 201324_AT, 213503_X_AT, 214297_AT, 
               
               
                   
                 212171_X_AT, 204575_S_AT, 210427_X_AT, 201566_X_AT, 228964_AT, 226218_AT, 
               
               
                   
                 218559_S_AT, 207233_S_AT, 206835_AT, 207433_AT, 210512_S_AT, 202827_S_AT, 
               
               
                   
                 222670_S_AT, 205419_AT, 211527_X_AT, 204465_S_AT, 203140_AT, 1560960_AT, 
               
               
                   
                 220935_S_AT, 210510_S_AT, 210513_S_AT, 208978_AT, 213931_AT, 208712_AT, 
               
               
                   
                 212614_AT, 204881_S_AT, 222876_S_AT, 229797_AT 
               
               
                 GO: 0002697~regulation 
                 205798_AT, 203665_AT, 205891_AT, 203140_AT, 222062_AT, 217757_AT, 
               
               
                 of immune effector 
                 207433_AT, 220066_AT, 226218_AT, 202638_S_AT, 215990_S_AT 
               
               
                 process 
               
               
                 GO: 0051384~response 
                 208712_AT, 217757_AT, 203980_AT, 207433_AT, 204655_AT, 1405_I_AT, 
               
               
                 to glucocorticoid 
                 202284_S_AT, 1555759_A_AT, 215813_S_AT, 210145_AT, 205128_X_AT, 
               
               
                 stimulus 
                 238669_AT 
               
               
                 GO: 0005624~membrane 
                 1553995_A_AT, 202869_AT, 209555_S_AT, 205552_S_AT, 202435_S_AT, 
               
               
                 fraction 
                 202609_AT, 223596_AT, 222877_AT, 227134_AT, 211066_X_AT, 204661_AT, 
               
               
                   
                 34210_AT, 219412_AT, 202434_S_AT, 218613_AT, 206488_S_AT, 210146_X_AT, 
               
               
                   
                 215836_S_AT, 208789_AT, 203939_AT, 1554992_AT, 203665_AT, 202436_S_AT, 
               
               
                   
                 202437_S_AT, 216080_S_AT, 208161_S_AT, 210145_AT, 1557938_S_AT, 
               
               
                   
                 236345_AT, 238669_AT, 204257_AT, 204881_S_AT, 210004_AT, 228766_AT, 
               
               
                   
                 241929_AT, 203355_S_AT, 209993_AT, 215813_S_AT, 201324_AT, 205128_X_AT 
               
               
                 hsa04060:Cytokine- 
                 214581_X_AT, 204912_AT, 212171_X_AT, 202727_S_AT, 1405_I_AT, 204655_AT, 
               
               
                 cytokine receptor 
                 210513_S_AT, 211676_S_AT, 226218_AT, 223501_AT, 218856_AT, 205898_AT, 
               
               
                 interaction 
                 223502_S_AT, 205099_S_AT, 203104_AT, 205798_AT, 204116_AT, 207433_AT, 
               
               
                   
                 210512_S_AT, 1555759_A_AT, 221463_AT, 211527_X_AT, 242903_AT 
               
               
                 GO: 0031349~positive 
                 205891_AT, 203980_AT, 1405_I_AT, 204655_AT, 221060_S_AT, 1552798_A_AT, 
               
               
                 regulation of defense 
                 210145_AT, 224341_X_AT, 1555756_A_AT, 1555759_A_AT, 232068_S_AT, 
               
               
                 response 
                 208436_S_AT, 220066_AT 
               
               
                 GO: 0048584~positive 
                 209906_AT, 205891_AT, 212171_X_AT, 203980_AT, 1405_I_AT, 204655_AT, 
               
               
                 regulation of response to 
                 210513_S_AT, 221060_S_AT, 1552798_A_AT, 223501_AT, 210145_AT, 
               
               
                 stimulus 
                 223502_S_AT, 222062_AT, 224341_X_AT, 225097_AT, 1555756_A_AT, 
               
               
                   
                 210512_S_AT, 1555759_A_AT, 220066_AT, 232068_S_AT, 208436_S_AT, 
               
               
                   
                 211527_X_AT 
               
               
                 GO: 0031960~response 
                 208712_AT, 217757_AT, 203980_AT, 207433_AT, 204655_AT, 1405_I_AT, 
               
               
                 to corticosteroid 
                 202284_S_AT, 1555759_A_AT, 215813_S_AT, 210145_AT, 205128_X_AT, 
               
               
                 stimulus 
                 238669_AT 
               
               
                 GO: 0042221~response 
                 229221_AT, 201069_AT, 202435_S_AT, 222877_AT, 202434_S_AT, 202284_S_AT, 
               
               
                 to chemical stimulus 
                 220066_AT, 200878_AT, 203665_AT, 207542_S_AT, 202436_S_AT, 201565_S_AT, 
               
               
                   
                 209921_AT, 210145_AT, 224341_X_AT, 203887_S_AT, 1555756_A_AT, 209392_AT, 
               
               
                   
                 201242_S_AT, 209993_AT, 215813_S_AT, 209122_AT, 205128_X_AT, 237252_AT, 
               
               
                   
                 212171_X_AT, 1405_I_AT, 201566_X_AT, 221060_S_AT, 202609_AT, 218934_S_AT, 
               
               
                   
                 204058_AT, 205898_AT, 205099_S_AT, 211661_X_AT, 207433_AT, 217678_AT, 
               
               
                   
                 210512_S_AT, 202827_S_AT, 209047_AT, 221463_AT, 232068_S_AT, 211527_X_AT, 
               
               
                   
                 235286_AT, 209906_AT, 217757_AT, 204059_S_AT, 203980_AT, 204655_AT, 
               
               
                   
                 210513_S_AT, 202437_S_AT, 1552798_A_AT, 213931_AT, 238669_AT, 203888_AT, 
               
               
                   
                 208712_AT, 210004_AT, 1555759_A_AT, 201243_S_AT 
               
               
                 GO: 0065007~biological 
                 213891_S_AT, 1553995_A_AT, 223723_AT, 212298_AT, 223660_AT, 222838_AT, 
               
               
                 regulation 
                 219412_AT, 205798_AT, 205960_AT, 209348_S_AT, 217997_AT, 232333_AT, 
               
               
                   
                 225171_AT, 220307_AT, 201565_S_AT, 201590_X_AT, 230266_AT, 209684_AT, 
               
               
                   
                 204999_S_AT, 204653_AT, 226066_AT, 215990_S_AT, 221815_AT, 203104_AT, 
               
               
                   
                 200884_AT, 204834_AT, 222146_S_AT, 228766_AT, 210095_S_AT, 205128_X_AT, 
               
               
                   
                 214211_AT, 1560485_AT, 214581_X_AT, 63825_AT, 1405_I_AT, 201566_X_AT, 
               
               
                   
                 228964_AT, 211719_X_AT, 223501_AT, 212387_AT, 205898_AT, 205099_S_AT, 
               
               
                   
                 218502_S_AT, 206835_AT, 207433_AT, 235944_AT, 222670_S_AT, 212382_AT, 
               
               
                   
                 1554992_AT, 217757_AT, 1545754_X_AT, 209606_AT, 211676_S_AT, 206675_S_AT, 
               
               
                   
                 225842_AT, 216250_S_AT, 238669_AT, 1565752_AT, 204105_S_AT, 206134_AT, 
               
               
                   
                 202638_S_AT, 227948_AT, 242794_AT, 202434_S_AT, 222858_S_AT, 206488_S_AT, 
               
               
                   
                 211962_S_AT, 225173_AT, 208789_AT, 220066_AT, 200878_AT, 225166_AT, 
               
               
                   
                 203665_AT, 205891_AT, 208816_X_AT, 239519_AT, 233540_S_AT, 218856_AT, 
               
               
                   
                 210145_AT, 212190_AT, 223502_S_AT, 212143_S_AT, 1557938_S_AT, 215602_AT, 
               
               
                   
                 223939_AT, 203887_S_AT, 206637_AT, 1555756_A_AT, 222651_S_AT, 
               
               
                   
                 215813_S_AT, 218501_AT, 227240_AT, 210427_X_AT, 226218_AT, 218934_S_AT, 
               
               
                   
                 244579_AT, 204661_AT, 207233_S_AT, 210895_S_AT, 222062_AT, 232746_AT, 
               
               
                   
                 227265_AT, 210512_S_AT, 225188_AT, 211527_X_AT, 244414_AT, 203140_AT, 
               
               
                   
                 242405_AT, 1569150_X_AT, 201952_AT, 203980_AT, 225189_S_AT, 230559_X_AT, 
               
               
                   
                 210264_AT, 213931_AT, 210258_AT, 222876_S_AT, 210757_X_AT, 201280_S_AT, 
               
               
                   
                 201951_AT, 219358_S_AT, 210495_X_AT, 229221_AT, 209555_S_AT, 202435_S_AT, 
               
               
                   
                 221011_S_AT, 210360_S_AT, 217999_S_AT, 224480_S_AT, 203936_S_AT, 
               
               
                   
                 228057_AT, 214255_AT, 202284_S_AT, 242903_AT, 1569149_AT, 228490_AT, 
               
               
                   
                 207610_S_AT, 209568_S_AT, 203753_AT, 1553982_A_AT, 212977_AT, 201422_AT, 
               
               
                   
                 230925_AT, 243556_AT, 201005_AT, 203060_S_AT, 213293_S_AT, 237252_AT, 
               
               
                   
                 212171_X_AT, 214297_AT, 202727_S_AT, 235457_AT, 221060_S_AT, 223596_AT, 
               
               
                   
                 34210_AT, 223398_AT, 205566_AT, 218613_AT, 221463_AT, 232068_S_AT, 
               
               
                   
                 208436_S_AT, 209906_AT, 243483_AT, 210510_S_AT, 210513_S_AT, 212614_AT, 
               
               
                   
                 212386_AT, 225097_AT, 219994_AT, 1556423_AT, 203355_S_AT, 224218_S_AT, 
               
               
                   
                 201278_AT, 206171_AT, 1560228_AT, 237442_AT, 203939_AT, 218589_AT, 
               
               
                   
                 202436_S_AT, 201279_S_AT, 204998_S_AT, 234645_AT, 206157_AT, 225337_AT, 
               
               
                   
                 224341_X_AT, 209392_AT, 229435_AT, 201324_AT, 205681_AT, 212464_S_AT, 
               
               
                   
                 216442_X_AT, 213503_X_AT, 1553906_S_AT, 228708_AT, 202609_AT, 
               
               
                   
                 218559_S_AT, 211661_X_AT, 214841_AT, 204116_AT, 225207_AT, 202827_S_AT, 
               
               
                   
                 223092_AT, 205419_AT, 87100_AT, 228368_AT, 220935_S_AT, 204655_AT, 
               
               
                   
                 1552553_A_AT, 202437_S_AT, 203037_S_AT, 214054_AT, 1552798_A_AT, 
               
               
                   
                 208978_AT, 203888_AT, 237904_AT, 208712_AT, 1555759_A_AT, 241929_AT, 
               
               
                   
                 242157_AT, 219434_AT, 223394_AT 
               
               
                 GO: 0050865~regulation 
                 203665_AT, 203140_AT, 205891_AT, 221060_S_AT, 1552798_A_AT, 226218_AT, 
               
               
                 of cell activation 
                 223501_AT, 223502_S_AT, 215990_S_AT, 205798_AT, 210895_S_AT, 222062_AT, 
               
               
                   
                 224341_X_AT, 204116_AT, 207433_AT, 202284_S_AT, 232068_S_AT 
               
               
                 GO: 0048545~response 
                 203665_AT, 207542_S_AT, 203980_AT, 217757_AT, 1405_I_AT, 204655_AT, 
               
               
                 to steroid hormone 
                 210145_AT, 238669_AT, 208712_AT, 207433_AT, 1555759_A_AT, 202827_S_AT, 
               
               
                 stimulus 
                 202284_S_AT, 209047_AT, 215813_S_AT, 205128_X_AT 
               
               
                 GO: 0006935~chemotaxis 
                 209906_AT, 207433_AT, 204655_AT, 1405_I_AT, 1555759_A_AT, 209392_AT, 
               
               
                   
                 221463_AT, 222877_AT, 235286_AT, 205898_AT, 205099_S_AT, 211661_X_AT 
               
               
                 GO: 0042330~taxis 
                 209906_AT, 207433_AT, 204655_AT, 1405_I_AT, 1555759_A_AT, 209392_AT, 
               
               
                   
                 221463_AT, 222877_AT, 235286_AT, 205898_AT, 205099_S_AT, 211661_X_AT 
               
               
                 GO: 0002703~regulation 
                 205798_AT, 203665_AT, 205891_AT, 203140_AT, 222062_AT, 207433_AT, 
               
               
                 of leukocyte mediated 
                 220066_AT, 226218_AT, 215990_S_AT 
               
               
                 immunity 
               
               
                 GO: 0002822~regulation 
                 205798_AT, 203140_AT, 210895_S_AT, 222062_AT, 207433_AT, 220066_AT, 
               
               
                 of adaptive immune 
                 226218_AT, 223501_AT, 223502_S_AT, 215990_S_AT 
               
               
                 response based on 
               
               
                 somatic recombination 
               
               
                 of immune receptors 
               
               
                 built from 
               
               
                 immunoglobulin 
               
               
                 superfamily domains 
               
               
                 G0: 0001568~blood 
                 229221_AT, 203665_AT, 201069_AT, 214297_AT, 212298_AT, 213503_X_AT, 
               
               
                 vessel development 
                 212171_X_AT, 204575_S_AT, 208816_X_AT, 210510_S_AT, 239519_AT, 
               
               
                   
                 210427_X_AT, 210513_S_AT, 201590_X_AT, 222877_AT, 211962_S_AT, 
               
               
                   
                 202827_S_AT, 210512_S_AT, 211527_X_AT, 200878_AT 
               
               
                 G0: 0030154~cell 
                 220333_AT, 210495_X_AT, 229221_AT, 212298_AT, 222877_AT, 205798_AT, 
               
               
                 differentiation 
                 201278_AT, 211962_S_AT, 242871_AT, 203936_S_AT, 209348_S_AT, 230360_AT, 
               
               
                   
                 204141_AT, 200878_AT, 1569149_AT, 201279_S_AT, 204998_S_AT, 239519_AT, 
               
               
                   
                 201565_S_AT, 221266_S_AT, 233540_S_AT, 204999_S_AT, 226066_AT, 212190_AT, 
               
               
                   
                 215990_S_AT, 212143_S_AT, 220484_AT, 243556_AT, 210095_S_AT, 201324_AT, 
               
               
                   
                 212464_S_AT, 216442_X_AT, 212171_X_AT, 214297_AT, 204575_S_AT, 227240_AT, 
               
               
                   
                 201566_X_AT, 211719_X_AT, 228964_AT, 226218_AT, 207233_S_AT, 207433_AT, 
               
               
                   
                 210512_S_AT, 202827_S_AT, 205419_AT, 211527_X_AT, 204465_S_AT, 
               
               
                   
                 1554992_AT, 203140_AT, 1560960_AT, 201952_AT, 1569150_X_AT, 203980_AT, 
               
               
                   
                 220935_S_AT, 210510_S_AT, 210513_S_AT, 213931_AT, 204105_S_AT, 208712_AT, 
               
               
                   
                 210757_X_AT, 229797_AT, 201280_S_AT, 201951_AT 
               
               
                 GO: 0001944~vasculature 
                 229221_AT, 203665_AT, 201069_AT, 214297_AT, 212298_AT, 213503_X_AT, 
               
               
                 development 
                 212171_X_AT, 204575_S_AT, 208816_X_AT, 210510_S_AT, 239519_AT, 
               
               
                   
                 210427_X_AT, 210513_S_AT, 201590_X_AT, 222877_AT, 211962_S_AT, 
               
               
                   
                 202827_S_AT, 210512_S_AT, 211527_X_AT, 200878_AT 
               
               
                 G0: 0002819~regulation 
                 205798_AT, 203140_AT, 210895_S_AT, 222062_AT, 207433_AT, 220066_AT, 
               
               
                 of adaptive immune 
                 226218_AT, 223501_AT, 223502_S_AT, 215990_S_AT 
               
               
                 response 
               
               
                 GO: 0051241~negative 
                 203665_AT, 203140_AT, 205891_AT, 213503_X_AT, 212171_X_AT, 208816_X_AT, 
               
               
                 regulation of 
                 210427_X_AT, 210513_S_AT, 2101590_X_AT, 215990_S_AT, 206835_AT, 207433_AT, 
               
               
                 multicellular organismal 
                 210512_S_AT, 220066_AT, 211527_X_AT 
               
               
                 GO: 0051704~multi- 
                 237252_AT, 202727_S_AT, 1405_I_AT, 221060_S_AT, 205898_AT, 211661_X_AT, 
               
               
                 organism process 
                 210895_S_AT, 222062_AT, 204116_AT, 232746_AT, 207433_AT, 208436_S_AT, 
               
               
                   
                 220066_AT, 232068_S_AT, 204475_AT, 242903_AT, 37145_AT, 214453_S_AT, 
               
               
                   
                 204655_AT, 1552553_A_AT, 211676_S_AT, 1552798_A_AT, 229937_X_AT, 
               
               
                   
                 210145_AT, 206157_AT, 203888_AT, 212977_AT, 224341_X_AT, 203887_S_AT, 
               
               
                   
                 225097_AT, 205495_S_AT, 1555756_A_AT, 1555759_A_AT, 202638_S_AT, 
               
               
                   
                 213293_S_AT 
               
               
                 GO: 0007165~signal 
                 212298_AT, 209555_S_AT, 227948_AT, 223660_AT, 210360_S_AT, 219412_AT, 
               
               
                 transduction 
                 222858_S_AT, 205798_AT, 206488_S_AT, 205960_AT, 206171_AT, 225173_AT, 
               
               
                   
                 220066_AT, 200878_AT, 237442_AT, 242903_AT, 225166_AT, 218589_AT, 
               
               
                   
                 203655_AT, 205891_AT, 207610_S_AT, 225171_AT, 209568_S_AT, 220307_AT, 
               
               
                   
                 239519_AT, 230266_AT, 209684_AT, 218856_AT, 1553982_A_AT, 223502_S_AT, 
               
               
                   
                 203104_AT, 212977_AT, 223939_AT, 224341_X_AT, 204834_AT, 206637_AT, 
               
               
                   
                 228766_AT, 1555756_A_AT, 230925_AT, 214581_X_AT, 214297_AT, 218501_AT, 
               
               
                   
                 202727_S_AT, 1405_I_AT, 228708_AT, 221060_S_AT, 202609_AT, 226218_AT, 
               
               
                   
                 223501_AT, 205898_AT, 205099_S_AT, 211661_X_AT, 214841_AT, 204116_AT, 
               
               
                   
                 232746_AT, 225207_AT, 207433_AT, 227265_AT, 225188_AT, 221463_AT, 
               
               
                   
                 205419_AT, 232068_S_AT, 209906_AT, 228368_AT, 1554992_AT, 201952_AT, 
               
               
                   
                 210510_S_AT, 204655_AT, 225189_S_AT, 230559_X_AT, 214054_AT, 203037_S_AT, 
               
               
                   
                 210264_AT, 211676_S_AT, 1552798_A_AT, 216250_S_AT, 237904_AT, 208712_AT, 
               
               
                   
                 225097_AT, 219994_AT, 1555759_A_AT, 241929_AT, 219434_AT, 201951_AT 
               
               
                 GO: 0009617~response 
                 237252_AT, 1405_I_AT, 204655_AT, 1552553_A_AT, 221060_S_AT, 1552798_A_AT, 
               
               
                 to bacterium 
                 210145_AT, 203888_AT, 211661_X_AT, 222062_AT, 224341_X_AT, 203887_S_AT, 
               
               
                   
                 207433_AT, 205495_S_AT, 1555759_A_AT, 220066_AT, 232068_S_AT, 37145_AT 
               
               
                 GO: 0048519~negative 
                 213891_S_AT, 1553995_A_AT, 212298_AT, 224218_S_AT, 205798_AT, 201278_AT, 
               
               
                 regulation of biological 
                 228057_AT, 202284_S_AT, 220066_AT, 203939_AT, 228490_AT, 203665_AT, 
               
               
                 process 
                 205891_AT, 201279_S_AT, 204998_S_AT, 208816_X_AT, 201565_S_AT, 239519_AT, 
               
               
                   
                 203753_AT, 201590_X_AT, 204999_S_AT, 226066_AT, 223502_S_AT, 215990_S_AT, 
               
               
                   
                 221815_AT, 225337_AT, 212143_S_AT, 224341_X_AT, 201422_AT, 222146_S_AT, 
               
               
                   
                 222651_S_AT, 229435_AT, 201005_AT, 215813_S_AT, 210095_S_AT, 205681_AT, 
               
               
                   
                 205128_X_AT, 214211_AT, 1560485_AT, 212171_X_AT, 213503_X_AT, 63825_AT, 
               
               
                   
                 1405_I_AT, 221060_S_AT, 210427_X_AT, 201566_X_AT, 228964_AT, 226218_AT, 
               
               
                   
                 223501_AT, 212387_AT, 223398_AT, 244579_AT, 218559_S_AT, 205566_AT, 
               
               
                   
                 207233_S_AT, 222062_AT, 218502_S_AT, 206835_AT, 207433_AT, 210512_S_AT, 
               
               
                   
                 202827_S_AT, 222670_S_AT, 208436_S_AT, 232068_S_AT, 87100_AT, 
               
               
                   
                 211527_X_AT, 212382_AT, 203140_AT, 203980_AT, 217757_AT, 204655_AT, 
               
               
                   
                 210510_S_AT, 210513_S_AT, 1552798_A_AT, 206675_S_AT, 213931_AT, 
               
               
                   
                 238669_AT, 212614_AT, 208712_AT, 210258_AT, 210757_X_AT, 212386_AT, 
               
               
                   
                 206134_AT, 225097_AT, 1555759_A_AT, 1556423_AT, 201280_S_AT, 223394_AT 
               
               
                 GO: 0050864~regulation 
                 203140_AT, 222062_AT, 204116_AT, 207433_AT, 202284_S_AT, 223501_AT, 
               
               
                 of B cell activation 
                 223502_S_AT, 215990_S_AT 
               
               
                 GO: 0001525~angiogenesis 
                 203665_AT, 214297_AT, 213503_X_AT, 212171_X_AT, 212298_AT, 204575_S_AT, 
               
               
                   
                 208816_X_AT, 210510_S_AT, 210427_X_AT, 210513_S_AT, 239519_AT, 
               
               
                   
                 201590_X_AT, 222877_AT, 202827_S_AT, 210512_S_AT, 211527_X_AT, 200878_AT 
               
               
                 GO: 0048869~cellular 
                 220333_AT, 210495_X_AT, 229221_AT, 212298_AT, 222877_AT, 205798_AT, 
               
               
                 developments process 
                 201278_AT, 211962_S_AT, 242871_AT, 203936_S_AT, 209348_S_AT, 230360_AT, 
               
               
                   
                 204141_AT, 200878_AT, 1569149_AT, 201279_S_AT, 204998_S_AT, 239519_AT, 
               
               
                   
                 201565_S_AT, 221266_S_AT, 233540_S_AT, 204999_S_AT, 226066_AT, 212190_AT, 
               
               
                   
                 215990_S_AT, 212143_S_AT, 220484_AT, 201005_AT, 243556_AT, 210095_S_AT, 
               
               
                   
                 201324_AT, 212464_S_AT, 216442_X_AT, 212171_X_AT, 214297_AT, 204575_S_AT, 
               
               
                   
                 227240_AT, 201566_X_AT, 211719_X_AT, 228964_AT, 226218_AT, 207233_S_AT, 
               
               
                   
                 207433_AT, 210512_S_AT, 202827_S_AT, 205419_AT, 211527_X_AT, 204465_S_AT, 
               
               
                   
                 1554992_AT, 203140_AT, 1560960_AT, 201952_AT, 1569150_X_AT, 203980_AT, 
               
               
                   
                 220935_S_AT, 210510_S_AT, 210513_S_AT, 213931_AT, 204105_S_AT, 208712_AT, 
               
               
                   
                 210757_X_AT, 229797_AT, 201280_S_AT, 201951_AT 
               
               
                 GO: 0002694~regulation 
                 203140_AT, 205891_AT, 203665_AT, 226218_AT, 223501_AT, 215990_S_AT, 
               
               
                 of leukocyte activation 
                 223502_S_AT, 205798_AT, 210895_S_AT, 222062_AT, 204116_AT, 207433_AT, 
               
               
                   
                 202284_S_AT 
               
               
                 GO: 0044243~multicellular 
                 201069_AT, 204575_S_AT, 203936_S_AT, 204475_AT 
               
               
                 organismal catabolic 
               
               
                 process 
               
               
                 GO: 0030574~collagen 
                 201069_AT, 204575_S_AT, 203936_S_AT, 204475_AT 
               
               
                 cataboltc process 
               
               
                 GO: 0016477~cell 
                 216442_X_AT, 210495_X_AT, 229221_AT, 1560960_AT, 212298_AT, 210510_S_AT, 
               
               
                 migration 
                 1405_I_AT, 204655_AT, 239519_AT, 211719_X_AT, 222877_AT, 204268_AT, 
               
               
                   
                 204105_S_AT, 212614_AT, 207433_AT, 202827_S_AT, 1555759_A_AT, 235286_AT, 
               
               
                   
                 202638_S_AT, 212464_S_AT 
               
               
                 GO: 0045595~regulation 
                 212298_AT, 209555_S_AT, 1405_I_AT, 201566_X_AT, 221040_S_AT, 226218_AT 
               
               
                 of cell differentiation 
                 218559_S_AT, 205798_AT, 207233_S_AT, 206488_S_AT, 210895_S_AT, 204116_AT, 
               
               
                   
                 209348_S_AT, 222670_S_AT, 232068_S_AT, 1569149_AT, 203140_AT, 
               
               
                   
                 1569150_X_AT, 204998_S_AT, 220935_S_AT, 210510_S_AT, 204655_AT, 
               
               
                   
                 239519_AT, 201565_S_AT, 1552798_A_AT, 233540_S_AT, 204999_S_AT, 
               
               
                   
                 226066_AT, 215990_S_AT, 213931_AT, 212143_S_AT, 204105_S_AT, 208712_AT, 
               
               
                   
                 224341_X_AT, 228766_AT, 1555759_A_AT, 241929_AT, 210095_S_AT 
               
               
                 GO: 0032879~regulation 
                 212298_AT, 212171_X_AT, 209555_S_AT, 63825_AT, 228708_AT, 205566_AT, 
               
               
                 of localization 
                 206488_S_AT, 207433_AT, 203936_S_AT, 210512_S_AT, 87100_AT, 220066_AT, 
               
               
                   
                 211527_X_AT, 228490_AT, 203665_AT, 203140_AT, 205891_AT, 210510_S_AT, 
               
               
                   
                 239519_AT, 210513_S_AT, 212190_AT, 210145_AT, 221815_AT, 215990_S_AT, 
               
               
                   
                 206157_AT, 212143_S_AT, 225337_AT, 238669_AT, 228766_AT, 1555756_A_AT, 
               
               
                   
                 209392_AT, 1556423_AT, 241929_AT, 210095_S_AT, 215813_S_AT, 202638_S_AT, 
               
               
                   
                 205128_X_AT 
               
               
                 GO: 0050729~positive 
                 205891_AT, 224341_X_AT, 203980_AT, 204655_AT, 1405_I_AT, 221060_S_AT, 
               
               
                 regulation of 
                 1555759_A_AT, 232068_S_AT, 1552798_A_AT, 210145_AT 
               
               
                 inflammatory response 
               
               
                 GO: 0007186~G-protein 
                 218589_AT, 209906_AT, 205891_AT, 207610_S_AT, 223660_AT, 1405_I_AT, 
               
               
                 coupled receptor protein 
                 204655_AT, 210264_AT, 205898_AT, 205099_S_AT, 237904_AT, 211661_X_AT, 
               
               
                 signaling pathway 
                 212977_AT, 210258_AT, 232746_AT, 223939_AT, 206171_AT, 206637_AT, 
               
               
                   
                 1555759_A_AT, 209392_AT, 205419_AT 
               
               
                 GO: 0051270~regulation 
                 228490_AT, 203665_AT, 203140_AT, 212298_AT, 212171_X_AT, 63825_AT, 
               
               
                 of cell motion 
                 210510_S_AT, 239519_AT, 210513_S_AT, 212190_AT, 215990_S_AT, 221815_AT, 
               
               
                   
                 212143_S_AT, 205566_AT, 225337_AT, 203936_S_AT, 210512_S_AT, 209392_AT, 
               
               
                   
                 1556423_AT, 87100_AT, 211527_X_AT, 210095_S_AT, 202638_S_AT 
               
               
                 GO: 0048518~positive 
                 213891_S_AT, 229221_AT, 212298_AT, 209555_S_AT, 227948_AT, 222838_AT, 
               
               
                 regulation of biological 
                 242794_AT, 205798_AT, 206488_S_AT, 217999_S_AT, 217997_AT, 209348_S_AT, 
               
               
                 process 
                 203936_S_AT, 202284_S_AT, 220066_AT, 232333_AT, 200878_AT, 1569149_AT, 
               
               
                   
                 205891_AT, 203665_AT, 201565_S_AT, 239519_AT, 203753_AT, 234645_AT, 
               
               
                   
                 210145_AT, 226066_AT, 215990_S_AT, 206157_AT, 223502_S_AT, 212143_S_AT, 
               
               
                   
                 215602_AT, 224341_X_AT, 222146_S_AT, 228766_AT, 1555756_A_AT, 243556_AT, 
               
               
                   
                 229435_AT, 215813_S_AT, 210095_S_AT, 205128_X_AT, 212171_X_AT, 218501_AT, 
               
               
                   
                 1553906_S_AT, 227240_AT, 1405_I_AT, 201566_X_AT, 235457_AT, 221060_S_AT, 
               
               
                   
                 228964_AT, 226218_AT, 223501_AT, 212387_AT, 218559_S_AT, 207233_S_AT, 
               
               
                   
                 210895_S_AT, 222062_AT, 204116_AT, 207433_AT, 222670_S_AT, 210512_S_AT, 
               
               
                   
                 232068_S_AT, 208436_S_AT, 211527_X_AT, 244414_AT, 212382_AT, 209906_AT, 
               
               
                   
                 1554992_AT, 203140_AT, 1569150_X_AT, 242405_AT, 203980_AT, 210510_S_AT, 
               
               
                   
                 204655_AT, 1552553_A_AT, 230559_X_AT, 210513_S_AT, 1565754_X_AT, 
               
               
                   
                 1552798_A_AT, 208978_AT, 225842_AT, 213931_AT, 238669_AT, 1565752_AT, 
               
               
                   
                 204105_S_AT, 208712_AT, 212386_AT, 225097_AT, 1555759_A_AT, 241929_AT, 
               
               
                   
                 202638_S_AT, 223394_AT 
               
               
                 GO: 001816~cytokine 
                 224341_X_AT, 203980_AT, 1552553_A_AT, 209348_S_AT, 221060_S_AT, 
               
               
                 production 
                 220066_AT, 232068_S_AT, 1552798_A_AT, 211661_X_AT 
               
               
                 GO: 0007610~behavior 
                 209906_AT, 1554992_AT, 1405_I_AT, 204655_AT, 202609_AT, 222877_AT, 
               
               
                   
                 205898_AT, 205099_S_AT, 211661_X_AT, 220484_AT, 225097_AT, 207433_AT, 
               
               
                   
                 229797_AT, 223092_AT, 1555759_A_AT, 209392_AT, 221463_AT, 235286_AT 
               
               
                 GO: 00550878~regulation 
                 237252_AT, 213503_X_AT, 209555_S_AT, 208816_X_AT, 210427_X_AT, 
               
               
                 of body fluid levels 
                 201590_X_AT, 203888_AT, 206488_S_AT, 206835_AT, 203887_S_AT, 228766_AT, 
               
               
                   
                 235944_AT, 241929_AT, 201005_AT, 203060_S_AT 
               
               
                 GO: 0032496~response 
                 237252_AT, 1405_I_AT, 204655_AT, 221060_S_AT, 1552798_A_AT, 210145_AT, 
               
               
                 to lipopolysaccharide 
                 203888_AT, 211661_X_AT, 224341_X_AT, 203887_S_AT, 207433_AT, 
               
               
                   
                 1555759_A_AT, 232068_S_AT, 220066_AT 
               
               
                 GO: 0002683~negative 
                 205798_AT, 203665_AT, 203140_AT, 222062_AT, 217757_AT, 207433_AT, 
               
               
                 regulation of immune 
                 220066_AT, 226218_AT, 215990_S_AT 
               
               
                 GO: 0051674~localization 
                 216442_X_AT, 210495_X_AT, 229221_AT, 1560960_AT, 212298_AT, 210510_S_AT, 
               
               
                 of cell 
                 1405_I_AT, 204655_AT, 239519_AT, 211719_X_AT, 222877_AT, 204268_AT, 
               
               
                   
                 204105_S_AT, 212614_AT, 207433_AT, 202827_S_AT, 1555759_A_AT, 235286_AT, 
               
               
                   
                 202638_S_AT, 212464_S_AT 
               
               
                 GO: 0048870~cell motility 
                 216442_X_AT, 210495_X_AT, 229221_AT, 1560960_AT, 212298_AT, 210510_S_AT, 
               
               
                   
                 1405_I_AT, 204655_AT, 239519_AT, 211719_X_AT, 222877_AT, 204268_AT, 
               
               
                   
                 204105_S_AT, 212614_AT, 207433_AT, 202827_S_AT, 1555759_A_AT, 235286_AT, 
               
               
                   
                 202638_S_AT, 212464_S_AT 
               
               
                 GO: 0046903~secretion 
                 203665_AT, 205891_AT, 207542_S_AT, 213503_X_AT, 201279_S_AT, 208816_X_AT, 
               
               
                   
                 1405_I_AT, 204655_AT, 210427_X_AT, 1552553_A_AT, 201590_X_AT, 227134_AT, 
               
               
                   
                 223501_AT, 223502_S_AT, 201278_AT, 206835_AT, 210757_X_AT, 1555759_A_AT, 
               
               
                   
                 209047_AT, 201280_S_AT, 235286_AT 
               
               
                 GO: 0006928~cell motion 
                 210495_X_AT, 216442_X_AT, 229221_AT, 212298_AT, 1405_I_AT, 211719_X_AT, 
               
               
                   
                 210360_S_AT, 222877_AT, 204268_AT, 207433_AT, 202827_S_AT, 235286_AT, 
               
               
                   
                 1560960_AT, 201952_AT, 204655_AT, 210510_S_AT, 239519_AT, 203037_S_AT, 
               
               
                   
                 212614_AT, 204105_S_AT, 1555759_A_AT, 209392_AT, 201005_AT, 201951_AT, 
               
               
                   
                 202638_S_AT, 212464_S_AT 
               
               
                 GO: 0048514~blood 
                 203665_AT, 214297_AT, 213503_X_AT, 212171_X_AT, 212298_AT, 204575_S_AT, 
               
               
                 vessel morphogenesis 
                 208816_X_AT, 210510_S_AT, 239519_AT, 210427_X_AT, 210513_S_AT, 
               
               
                   
                 201590_X_AT, 222877_AT, 211962_S_AT, 202827_S_AT, 210512_S_AT, 
               
               
                   
                 211527_X_AT, 200878_AT 
               
               
                 GO: 0001501~skeletal 
                 201069_AT, 213503_X_AT, 1569150_X_AT, 210427_X_AT, 201590_X_AT, 
               
               
                 system development 
                 224218_S_AT, 204653_AT, 244579_AT, 212143_S_AT, 212614_AT, 206835_AT, 
               
               
                   
                 218502_S_AT, 203936_S_AT, 202827_S_AT, 223092_AT, 222651_S_AT, 
               
               
                   
                 203060_S_AT, 210095_S_AT, 1569149_AT 
               
               
                 GO: 0050867~positive 
                 203140_AT, 205891_AT, 221060_S_AT, 1552798_A_AT, 226218_AT, 223501_AT, 
               
               
                 regulation of cell 
                 223502_S_AT, 215990_S_AT, 205798_AT, 210895_S_AT, 224341_X_AT, 204116_AT, 
               
               
                 activation 
                 202284_S_AT, 232068_S_AT 
               
               
                 GO: 0030247~polysaccharide 
                 229221_AT, 216442_X_AT, 210495_X_AT, 212171_X_AT, 210513_S_AT, 
               
               
                 binding 
                 211719_X_AT, 212190_AT, 206157_AT, 1555756_A_AT, 210512_S_AT, 220066_AT, 
               
               
                   
                 209392_AT, 211527_X_AT, 212464_S_AT 
               
               
                 GO: 0001871~pattern 
                 229221_AT, 216442_X_AT, 210495_X_AT, 212171_X_AT, 210513_S_AT, 
               
               
                 binding 
                 211719_X_AT, 212190_AT, 206157_AT, 1555756_A_AT, 210512_S_AT, 220066_AT, 
               
               
                   
                 209392_AT, 211527_X_AT, 212464_S_AT 
               
               
                 GO: 0004222~metalloendopeptidase 
                 201069_AT, 206134_AT, 204575_S_AT, 229004_AT, 203936_S_AT, 202827_S_AT, 
               
               
                 activity 
                 204475_AT 
               
               
                 GO: 0002698~negative 
                 205798_AT, 203665_AT, 203140_AT, 217757_AT, 226218_AT, 215990_S_AT 
               
               
                 regulation of immune 
               
               
                 effector process 
               
               
                 GO: 0002698~positive 
                 205891_AT, 212171_X_AT, 203980_AT, 1405_I_AT, 204655_AT, 221060_S_AT, 
               
               
                 regulation of response to 
                 210513_S_AT, 1552798_A_AT, 210145_AT, 224341_X_AT, 1555759_A_AT, 
               
               
                 external stimulus 
                 210512_S_AT, 232068_S_AT, 211527_X_AT 
               
               
                 GO: 0010033~response 
                 237252_AT, 229221_AT, 202435_S_AT, 1405_I_AT, 201566_X_AT, 221060_S_AT, 
               
               
                 to organic substance 
                 202609_AT, 218934_S_AT, 204058_AT, 211661_X_AT, 202434_S_AT, 207433_AT, 
               
               
                   
                 202827_S_AT, 202284_S_AT, 209047_AT, 220066_AT, 232068_S_AT, 203665_AT, 
               
               
                   
                 207542_S_AT, 202436_S_AT, 217757_AT, 204059_S_AT, 203980_AT, 204655_AT, 
               
               
                   
                 202437_S_AT, 201565_S_AT, 1552798_A_AT, 210145_AT, 213931_AT, 203888_AT, 
               
               
                   
                 238669_AT, 208712_AT, 203887_S_AT, 224341_X_AT, 1555756_A_AT, 
               
               
                   
                 1555759_A_AT, 215813_S_AT, 209122_AT, 205128_X_AT 
               
               
                   
               
             
          
           
               
                   
                 Term 
                 Genes 
               
               
                   
                   
               
             
          
           
               
                   
                 Enriched among top downregulated genes: 
               
             
          
           
               
                   
                 GO: 0007275~multicellular 
                 BMP8B, TEAD4, FLOT2, IRX3, ADAMTS1, DZIP1, CSPGS, 
               
               
                   
                 organismal 
                 COL8A2, EBF3, TSPAN2, FKBP4, HK2P1, CXCR4, GFI1, 
               
               
                   
                 development 
                 FLOT2, SIK1, DMRT2, TPDS2, TPDS2, WT1, TPDS2, 
               
               
                   
                   
                 WNT3, LGR4, SLC1A3, BCL11A, BCL2, SPRY1, PCDH8, 
               
               
                   
                   
                 CNTN4, BCL11A, ECE2, BMP8B, CXCR4, CAV1, WT1, 
               
               
                   
                   
                 KCNQ4, POU4F2, CXCR4, KAZ, OSR2, RET, COL8A2, 
               
               
                   
                   
                 BCL11A, BCL2, PKP2 
               
               
                   
                 GO: 0048731~system 
                 BMP8B, TEAD4, FLOT2, IRX3, ADAMTS1, CSPG5, 
               
               
                   
                 development 
                 COLBA2, TSPAN2, HK2P1, CXCR4, GFI1, FLOT2, DMRT2, 
               
               
                   
                   
                 TPD52, TPD52, WT1, TPD52, WNT3, LGR4, SLC1A3, 
               
               
                   
                   
                 BCL2, BCL11A, SPRY1, PCDH8, CHTN4, BCL11A, ECE2, 
               
               
                   
                   
                 BMP8B, CXCR4, WT1, CAV1, KCNQ4, POU4F2, CXCR4, 
               
               
                   
                   
                 KAZ, OSR2, RET, COL8A2, BCL11A, BCL2, PKP2 
               
               
                   
                 GO: 0048513~organ 
                 BMP8B, TEAD4, FLOT2, ADAMTS1, COLBA2, HK2P1, 
               
               
                   
                 development 
                 CXCR4, GFI1, FLOT2, DMRT2, TPD52, TPD52, WT1, 
               
               
                   
                   
                 TPD52, WNT3, LGR4, BCL2, BCL11A, SPRY1, PCDH8, 
               
               
                   
                   
                 CMTN4, BCL11A, ECE2, BMP8B, CXCR4, WT1, CAV1, 
               
               
                   
                   
                 KCNQ4, POU4F2, CXCR4, KAZ, RET, OSR2, COL8A2, BCL2, 
               
               
                   
                   
                 BCL11A, PKP2 
               
               
                   
                 GO: 0048856~anatomical 
                 BMP8B, TEAD4, FLOT2, IRX3, ADAMTS1, CSPG5, 
               
               
                   
                 structure development 
                 COL8A2, TSPAN2, HK2P1, CXCR4, GFI1, FLOT2, DMRT2, 
               
               
                   
                   
                 TPD52, TPD52, WT1, TPD52, WNT3, LGR4, SLC1A3, 
               
               
                   
                   
                 BCL2, BCL11A, SPRY1, PCDH8, CNTN4, BCL11A, ECE2, 
               
               
                   
                   
                 BMP8B, CXCR4, WT1, CAV1, KCNQ4, POU4F2, CXCR4, 
               
               
                   
                   
                 KAZ, OSR2, RET, COL8A2, BCL11A, BCL2, PKP2 
               
               
                   
                 GO: 0030154~cell 
                 BMP8B, TDRD7, TEAD4, IRX3, DZIP1, CSPG5, TSPAN2, 
               
               
                   
                 differentiation 
                 CXCR4, GFI1, SIK1, TPO52, TPD52, WT1, TPD52, WNT3, 
               
               
                   
                   
                 SLC1A3, BCL11A, BCL2, SPRY1, CNTN4, BCL11A, ECE2, 
               
               
                   
                   
                 BMP8B, CAV1, WT2, CXCR4, POU4F2, CXCR4, KAZ, RET, 
               
               
                   
                   
                 BCX11A, BCL2 
               
               
                   
                 GO: 0032502~developmental 
                 BMP8B, TDRD7, TEAD4, FLOT2, IRX3, ADAMTS1, DZIP1, 
               
               
                   
                 process 
                 CSPG5, COLBA2, EBF3, TSPAN2, FKBP4, HK2P1, CXCR4, 
               
               
                   
                   
                 GFI1, FLOT2, SIK1, DMRT2, TPD52, TPD52, WT1, TPD52, 
               
               
                   
                   
                 WNT3, LGR4, SLC1A3, BCL11A, BCL2, SPRY1, PCDH8, 
               
               
                   
                   
                 CNTN4, BCL11A, ECE2, BMP8B, CXCR4, CAV1, WT1, 
               
               
                   
                   
                 KCNQ4, POU4F2, CXCR4, KAZ, OSR2, RET, COLBA2, 
               
               
                   
                   
                 BCL11A, BCL2, PKP2 
               
               
                   
                 GO: 0003006~reproductive 
                 TDRD7, LGR4, BCL2, AQAMTS1, DZIP1, WT1, CXCR4, 
               
               
                   
                 developmental 
                 FKBP4, CXCR4, CXCR4, BCL2, DMRT2, WT1 
               
               
                   
                 process 
               
               
                   
                 GO: 0048869~cellular 
                 BMP8B, TDRD7, TEAD4, IRX3, DZIP1, CSPG5, TSPAN2, 
               
               
                   
                 developmental process 
                 CXCR4, GFI1, SIK1, TPD52, TPD52, WT1, TPD52, WNT3, 
               
               
                   
                   
                 SLC1A3, BCL11A, BCL2, SPRY1, CNTN4, BCL11A, ECE2, 
               
               
                   
                   
                 BMP8B, CAV1, WT1, CXCR4, POU4F2, CXCR4, KAZ, RET, 
               
               
                   
                   
                 BCL11A, BCL2 
               
               
                   
                 GO: 0009653~anatomical 
                 TEAD4, ADAMTS1, CQLBA2, CXCR4, GFI1, TPD52, TPD52, 
               
               
                   
                 structure morphogenesis 
                 WT1, TPD52, WNT3, LGR4, SLC1A3, BCL2, CNTN4, 
               
               
                   
                   
                 PCDH8, WT1, CXCR4, CAV1, KCNQ4, POU4F2, OSR2, 
               
               
                   
                   
                 RET, CXCR4, COL8A2, BCL2 
               
             
          
           
               
                   
                 Enriched among top upregulated genes: 
               
             
          
           
               
                   
                 GO: 0005886~plasma 
                 ADAP2, NT5E, FN1, CD44, MFI2, NRP1, CD36, ADORA3, 
               
               
                   
                 membrane 
                 PCDHGA12, RAB3S, IL7R. KCNQ3, GLDN, CD109, 
               
               
                   
                   
                 IFNGR1, EMR2, CD244, SLC43A2, ANXA2P1, CYBB, 
               
               
                   
                   
                 LILRB1, SLC38A6, CSF1R, CXCR7, GPC1, CD36, APBB1IP, 
               
               
                   
                   
                 NGEF, CD9, ATP1B1, GBP2, PLIN2, PTGS1, FTHL3, THBD, 
               
               
                   
                   
                 CSPG4, IFNGR1, TLR4, FN1, SLC12A6, TNFSF13B, 
               
               
                   
                   
                 CX3CR1, CD52, CCR1, PSD3, LILRB2, PCDHGA12, 
               
               
                   
                   
                 SLC7A11, TLR4, AQP1, GBP5, RASGRF1, C3AR1, TRPM8, 
               
               
                   
                   
                 NRP1, SLC6A6, IFNGR1, PTPRO, PTGS1, NRCAM, 
               
               
                   
                   
                 APBB1IP, ITGB5, PSD3, ICAM1, ATP1B1, IL10RA, MMP2, 
               
               
                   
                   
                 CD180, SLC43A2, NRP2, SYTL1, ST3GAL5, CD109, EVL, 
               
               
                   
                   
                 CD36, ADORA3, PTRF, ATP6V0D2, NOD2, PCDH7, 
               
               
                   
                   
                 APBB1IP, NT5E, STEAP1, LPAR6, SLC41A2, COL6A1, 
               
               
                   
                   
                 LOC100131909, HMOX1, AQP1, GBP2, ANXA2P2, NRP1, 
               
               
                   
                   
                 ABCC3, TM7SF4, SLC7A11, TNFSF13B, PTRF, LMNA, 
               
               
                   
                   
                 MCOLN3, THBD, TLR4, SUCNR1, P2RY14, CLEC7A, 
               
               
                   
                   
                 ENPP2, ABCB1, PTGS1, EMP1, FN1, FN1, ANXA2P1, 
               
               
                   
                   
                 NGEF, ANXA2P1, EPS8, DIXDC1, IL7R, CD52, PTAFR, 
               
               
                   
                   
                 CD86, IL27RA, IL2RG, CXCR7, ANKH, RAPH1, MMP14, 
               
               
                   
                   
                 GPR183, SLC41A2, MDGA1, ALCAM, RAPH1, TLR4, 
               
               
                   
                   
                 GPR35, ITG87, ADORA3, THBD, SLC41A2, MTUS1, 
               
               
                   
                   
                 RGS13, OLR1, ADAP2, MCOLN3, PLEKHO1, CD36, 
               
               
                   
                   
                 TREM1, ALCAM 
               
               
                   
                 GO: 0031226~intrinsic to 
                 MFI2, CD44, CD36, ADORA3, ST3GAL5, CD36, ADORA3, 
               
               
                   
                 plasma membrane 
                 KCNQ3, PCDH7, IFNGR1, STEAP1, LOC100131909, AQP1, 
               
               
                   
                   
                 ABCC3, CYBB, CSF1R, GPC1, TLR4, THBD, CD36, ENPP2, 
               
               
                   
                   
                 CD9, ATP1B1, THBD, CSPG4, IFNGR1, TLR4, EPS8, 
               
               
                   
                   
                 SLC12A6, CD52, CD52, CX3CR1, CCR1, PTAFR, IL27RA, 
               
               
                   
                   
                 IL2RG, LILRB2, MMP14, ANKH, AQP1, GPR183, TLR4, 
               
               
                   
                   
                 C3AR1, MDGA1, SLC6A6, GPR35, IFNGR1, PTPRO, TLR4, 
               
               
                   
                   
                 ITG87, ADORA3, THBD, NRCAM, OLR1, CD36, ITG85, 
               
               
                   
                   
                 ICAM1, ATP1B1 
               
               
                   
                 GO: 0016020~membrane 
                 NT5E, MFI2, NRP1, ADORA3, SLAMF7, RAB38, IL7R, 
               
               
                   
                   
                 PDK4, KCNQ3, GDPD1, PHLDA1, CD109, MPZL3, GCNT1, 
               
               
                   
                   
                 CD244, SLC43A2, FADS3, ANXA2P1, CYBB, RHBDF1, 
               
               
                   
                   
                 ABHD2, CSF1R, GPC1, CD36, PTGS1, FTHL3, TNFRSF21, 
               
               
                   
                   
                 ABHD2, FN1, TNFSF13B, CX3CR1, CCR1, MARCH1, 
               
               
                   
                   
                 LILRB2, PCDHGA12, HMCN1, AQP1, GCNT1, RASGRF1, 
               
               
                   
                   
                 POPDC3, HAVCR2, IFNGR1, PHLDA1, PTGS1, FADS3, 
               
               
                   
                   
                 NRCAM, C4ORF34, ADAMDEC1, ICAM1, GCNT1, 
               
               
                   
                   
                 ATP1B1, IL10RA, SLC37A2, SLC43A2, SYTL1, NRP2, 
               
               
                   
                   
                 ATP9A, CYP1B1, DAPP1, GUPR1, CD109, TMEM39A, 
               
               
                   
                   
                 CD36, PTRF, ATP6V0D2, NOD2, PCDH7, STEAP1, 
               
               
                   
                   
                 TMEM158, HMOX1, LOC100131909, GBP2, ANXA2P2, 
               
               
                   
                   
                 NRP1, ABCC3, TNFRSF21, PLA2G4A, TNFSF13B, LPCAT2, 
               
               
                   
                   
                 TBXAS1, PTRF, DOCK4, LMNA, SUCNR1, THBD, P2RY14, 
               
               
                   
                   
                 KMO, CLEC7A, PTGS1, NGEF, ANXA2P1, IL7R, CD52, 
               
               
                   
                   
                 PARM1, CD86, IL27RA, CXCR7, VEGFA, RAPH1, VEGFA, 
               
               
                   
                   
                 C4ORF34, MDGA1, ALCAM, RAPH1, GPR35, ITG87, 
               
               
                   
                   
                 RGS13, DAB2, ADAP2, OLR1, MCOLN3, DAB2, ALCAM, 
               
               
                   
                   
                 PAQR5, ADAP2, FN1, CD44, CD36, CYP1B1, PCDHGA12, 
               
               
                   
                   
                 PHLDA1, AGPAT9, PAQR5, ATP10A, GLDN, IFNGR1, 
               
               
                   
                   
                 ABHD2, EMR2, LILRB1, SLC38A6, C40RF34, CXCR7, 
               
               
                   
                   
                 APBB1IP, NGEF, C09, ATP1B1, GBP2, PLIN2, THBD, 
               
               
                   
                   
                 VEGFA, CSPG4, ACPP, IFNGR1, TLR4, SLC12A6, CD52, 
               
               
                   
                   
                 ABHD2, PSD3, SLC7A11, TLR4, GBP5, CALHM2, C3AR1, 
               
               
                   
                   
                 TRPM8, NRP1, VEGFA, SLC6A6, PTPRO, GBP3, UGCG, 
               
               
                   
                   
                 HIPK2, APBB1IP, KMO, PSD3, ITGB5, GLIPR1, MMP2, 
               
               
                   
                   
                 CD180, ST3GAL5, DAB2, EVL, ADORA3, DSE, APBB1IP, 
               
               
                   
                   
                 NT5E, LPAR6, SLC41A2, COL6A1, CYP1B1, AQP1, 
               
               
                   
                   
                 CALHM2, DAB2, SLAMF8, TM7SF4, SLC7A11, ABHD2, 
               
               
                   
                   
                 MCOLN3, TLR4, LFNG, ENPP2, EMP1, ABCB1, FN1, 
               
               
                   
                   
                 GDPD1, FN1, ANXA2P1, RAB278, EPS8, DIXDC1, PTAFR, 
               
               
                   
                   
                 CNIH3, IL2RG, PDK4, SLAMF8, MMP14, ANKH, ABHD2, 
               
               
                   
                   
                 GPR183, CKLF, SLC41A2, HAVCR2, CYP1B1, TLR4, THBD, 
               
               
                   
                   
                 ADORA3, SLC41A2, MTUS1, PLEKHO1, CD36, TREM1 
               
               
                   
                 GO: 0005887~integral to 
                 MFI2, CD44, CD36, ADORA3, ST36AL5, CD36, ADORA3, 
               
               
                   
                 plasma membrane 
                 KCNQ3, PCDH7, IFNGR1, STEAP1, LOC10Q131909, AQP1, 
               
               
                   
                   
                 ABCC3, CYBB, CSF1R, GFC1, TLR4, THBD, CD36, ENPP2, 
               
               
                   
                   
                 CD9, ATP181, THBD, CSPG4, IFNGR1, TLR4, EPS8, 
               
               
                   
                   
                 SLC12A6, CD52, CD52, CX3CR1, CCR1, PTAFR, IL27RA, 
               
               
                   
                   
                 IL2RG, LILRB2, MMP14, ANKH, AQP1, GPH183, TLR4, 
               
               
                   
                   
                 C3AR1, SLC6A6, GPR35, IFNGR1, PTPRO, TLR4, ITG87, 
               
               
                   
                   
                 ADORA3, THBD, NRCAM, OLR1, CD36, ITG85, ICAM1, 
               
               
                   
                   
                 ATP181 
               
               
                   
                 GO: 0044459~plasma 
                 FN1, MFI2, CD44, CD36, ADORA3, SVTL1, ST3GAL5, 
               
               
                   
                 membrane part 
                 RAB38, IL7R, CD36, EVL, ADORA3, KCNQ3, PTRF, 
               
               
                   
                   
                 ATP6VOD2, PCDH7, AP881IP, IFNGR1, STEAP1, HMOX1, 
               
               
                   
                   
                 LOC100131909, AQP1, G8P2, CD244, ABCC3, CYBB, 
               
               
                   
                   
                 SLC38A6, PTRF, CSF1R, GPC1, TLR4, THBD, CD36, 
               
               
                   
                   
                 CLEC7A, APBB1IP, EWPP2, CD9, ATP1B1, ABCB1, GBF2, 
               
               
                   
                   
                 FN1, THBO, FN1, CSPG4, IFNGR1, TLR4, FN1, EPS8, 
               
               
                   
                   
                 DIXDC1, SLC12A6, IL7R, CD52, CD52, CX3CR1, CCR1, 
               
               
                   
                   
                 PTAFR, CD86, PSD3, IL27RA, IL2RG, LILRB2, MMP14, 
               
               
                   
                   
                 ANKH, RAPH1, AQP1, GPR183, TLR4, GBP5, C3AR1, 
               
               
                   
                   
                 MDGA1, TRPM8, ALCAM, RAPH1, SLC6A6, GPR35, 
               
               
                   
                   
                 IFNGR1, PTPRO, TLR4, ITGB7, ADORA3, THBD, NRCAM, 
               
               
                   
                   
                 OLR1, APBB1IP, CD36, PSD3, ITG85, ALCAM, ICAM1, 
               
               
                   
                   
                 ATP1B1 
               
               
                   
                 GO: 0005576~extracellular 
                 GLIPR1, CD44, MFI2, FN1, MMP2, NRP1, IL7R, GLIPR1, 
               
               
                   
                 region 
                 CD109, MMP9, CD109, GNLY, HMOX1, COL6A1, 
               
               
                   
                   
                 ANXA2P2, NRP1, ANXA2P1, SERPINE2, TNFSF13B, PTX3, 
               
               
                   
                   
                 IGFBP3, PRSS23, THBD, GPC1, IFI30, FGL2, GNLY, 
               
               
                   
                   
                 COL22A1, ENPP2, LFNG, IGFBP3, PGA5, PLIN2, FN1, 
               
               
                   
                   
                 THBD, FN1, ACPP, VEGFA, ANXA2P1, MMP19, CCL5, 
               
               
                   
                   
                 ANXA2P1, FN1, IL7R, TNFSF13B, STATH, IL10, FGL2, 
               
               
                   
                   
                 HMCN1, VEGFA, MMP14, CCL24, VEGFA, MMP1, CKLF, 
               
               
                   
                   
                 A2M, ADAMTS15, CCL5, NRP1, VEGFA, TH8D, OLR1, 
               
               
                   
                   
                 ADAMDEC1, CTSL1, CCL5, VASH1, TREM1, ICAM1 
               
               
                   
                 GO: 0031224~intrinsic to 
                 PAQR5, NT5E, CD44, MFI2, NRP1, CD36, ADORA3, 
               
               
                   
                 membrane 
                 SLAMF7, PCDHGA12, IL7R, AGPAT9, ATP10A, PAQR5, 
               
               
                   
                   
                 GDPD1, KCNQ3, GLDN, CD109, IFNGR1, MPZL3, ABHD2, 
               
               
                   
                   
                 EMR2, GCNT1, CD244, SLC43A2, FADS3, CTBB, RHBDF1, 
               
               
                   
                   
                 LILRB1, ABHD2, SLC38A6, C4ORF34, CSF1R, CXCR7, 
               
               
                   
                   
                 GPC1, CD36, CD9, ATP1B1, TNFRSF21, THBD, ACPP, 
               
               
                   
                   
                 CSPG4, ABHD2, IFNGR1, TLR4, SLC12A6, TNFSF13B, 
               
               
                   
                   
                 CX3CR1, CD52, CCR1, ABHD2, MARCH1, LILRB2, 
               
               
                   
                   
                 PCDHGA12, SLC7A11, TLR4, GCNT1, AQP1, CALHM2, 
               
               
                   
                   
                 C3AR1, TRPM8, NRP1, SLC6A6, HAVCR2, POPDC3, 
               
               
                   
                   
                 IFNGR1, PTPRO, FADS3, GBP3, C4ORF34, NRCAM, 
               
               
                   
                   
                 UGCG, ADAMDEC1, KMO, ITG85, ICAM1, GCNT1, 
               
               
                   
                   
                 ATP1B1, GLIPR1, IL10RA, SLC37A2, CD180, SLC43A2, 
               
               
                   
                   
                 NRP2, ST3GAL5, ATP9A, CD109, GLIPR1, CD36, 
               
               
                   
                   
                 TMEM39A, ADORA3, DSE, PCDH7, NT5E, STEAP1, 
               
               
                   
                   
                 TMEM15B, LPAR6, SLC41A2, LOC100131909, AQP1, 
               
               
                   
                   
                 CALHM2, NRP1, SLAMF8, ABCC3, TM7SF4, SLC7A11, 
               
               
                   
                   
                 TNFRSF21, PLA2G4A, LPCAT2, TNFSF13B, ABHD2, 
               
               
                   
                   
                 TBXAS1, MCOLN3, THBD, TLR4, SUCNR1, P2RY14, KMO, 
               
               
                   
                   
                 CLEC7A, ENPP2, LFNG, ABCB1, EMP1, GDPD1, RAB27B, 
               
               
                   
                   
                 EPS8, JL7R, CD52, PARM1, PTAFR, CNIH3, CD86, IL27RA, 
               
               
                   
                   
                 CXCR7, IL2RG, SLAMF8, ANKH, MMP14, GPR183, 
               
               
                   
                   
                 ABHD2, CKLF, C4ORF34, SLC41A2, MDGA1, HAVCR2, 
               
               
                   
                   
                 ALCAM, TLR4, GPR35, ITGB7, ADORA3, THBD, SLC41A2, 
               
               
                   
                   
                 OLR1, MCOLN3, CD36, TREM1, ALCAM 
               
               
                   
                 GO: 0004871~signal 
                 PAQR5, IL10RA, CD44, NRP1, CD36, ADORA3, CD180, 
               
               
                   
                 transducer activity 
                 SLAMF7, NRP2, IL7R, CD36, PDK4, ADORA3, PAQR5, 
               
               
                   
                   
                 EPAS1, IFNGR1, LPAR6, SLA, HMOX1, LOC100131909, 
               
               
                   
                   
                 EMR2, CD244, NRP1, TNFRSF21, RHBDF1, LILRB1, 
               
               
                   
                   
                 CSF1R, CXCR7, SUCNR1, TLR4, THBD, P2RY14, CD36, 
               
               
                   
                   
                 CLEC7A, ENPP2, TNFRSF21, THBD, CSPG4, IFNGR1, CCL5, 
               
               
                   
                   
                 TLR4, EPS8, DIXDC1, IL7R, CX3CR1, CCR1, PTAFR, CD86, 
               
               
                   
                   
                 IL27RA, IL2RG, CXCR7, PDK4, LILRB2, HMCN1, GPR183, 
               
               
                   
                   
                 TLR4, C3AR1, TRPM8, NRP1, CCL5, DOK2, IFNGR1, 
               
               
                   
                   
                 PTPRO, TLR4, GPR35, SKIL, ITG87, THBD, ADORA3, SLA, 
               
               
                   
                   
                 RGS13, OLR1, CCL5, CD36, ITGB5, TREM1, ICAM1 
               
               
                   
                 GO: 0060089~molecular 
                 PAQR5, IL10RA, CD44, NRP1, CD36, ADORA3, CD180, 
               
               
                   
                 transducer activity 
                 SLAMF7, NRP2, IL7R, CD36, PDK4, ADORA3, PAQR5, 
               
               
                   
                   
                 EPAS1, IFNGR1, LPAR6, SLA, HMOX1, LOC100131909, 
               
               
                   
                   
                 EMR2, CD244, NRP1, TNFRSF21, RHBDF1, LILRB1, 
               
               
                   
                   
                 CSF1R, CXCR7, SUCNR1, TLR4, TH8D, P2RY14, CD36, 
               
               
                   
                   
                 CLEC7A, ENPP2, TNFRSF21, THBD, CSPG4, IFNGR1, CCL5, 
               
               
                   
                   
                 TLR4, EPS8, DIXDC1, IL7R, CX3CR1, CCR1, PTAFR, CD86, 
               
               
                   
                   
                 IL27RA, IL2RG, CXCR7, PDK4, ULRB2, HMCN1, GPR183, 
               
               
                   
                   
                 TLR4, C3AR1, TRPM8, NRP1, CCL5, DOK2, IFNGR1, 
               
               
                   
                   
                 PTPRO, TLR4, GPR35, SKIL, ITGB7, THBD, ADORA3, SLA, 
               
               
                   
                   
                 RGS13, OLR1, CCL5, CD36, ITGB5, TREM1, ICAM1 
               
               
                   
                 GO: 0004872~receptor 
                 PAQR5, CD44, IL10RA, NRP1, CD36, ADORA3, CD180, 
               
               
                   
                 activity 
                 SLAMF7, NRP2, IL7R, CD36, ADORA3, PAQR5, IFNGR1, 
               
               
                   
                   
                 LPAR6, LOC100131909, EMR2, CD244, NRP1, TNFRSF21, 
               
               
                   
                   
                 RHBDF1, LILRB1, CSF1R, CXCR7, SUCNR1, TLR4, TH8D, 
               
               
                   
                   
                 CD36, P2RY14, CLEC7A, ENPP2, TNFRSF21, THBD, 
               
               
                   
                   
                 IFNGR1, TLR4, EPS8, IL7R, CX3CR1, CCR1, PTAFR, CD86, 
               
               
                   
                   
                 IL27HA, IL2RG, CXCR7, LILRB2, HMCN1, GPR183, TLR4, 
               
               
                   
                   
                 C3AR1, TRPM8, NRP1, GPR35, PTPRO, IFNGR1, TLR4, 
               
               
                   
                   
                 ITGB7, ADORA3, THBD, OLR1, CD36, ITGB5, TREM1, 
               
               
                   
                   
                 ICAM1 
               
               
                   
                 GO: 0044425~membrane 
                 NT5E, PAQR5, FN1, CD44, MFI2, NRP1, CD36, CYP1B1, 
               
               
                   
                 part 
                 ADORA3, SLAMF7, PCDHGA12, RAB38, IL7R, AGPAT9, 
               
               
                   
                   
                 ATP10A, PAQR5, GDPD1, KCNQ3, GLDN, CD109, MPZL3, 
               
               
                   
                   
                 IFNGR1, ABHD2, EMR2, GCNT1, CD244, SLC43A2, 
               
               
                   
                   
                 FADS3, CYBB, RHBDF1, LILRB1, ABHD2, SLC38A6, 
               
               
                   
                   
                 C4ORF34, CSF1R, CXCR7, GPC1, CD36, APBB1IP, CD9, 
               
               
                   
                   
                 ATP1B1, GBP2, PUN2, PTGS1, TNFRSF21, THBD, ACPP, 
               
               
                   
                   
                 CSPG4, ABHD2, IFNGR1, TLR4, FN1, SLC12A6, TNFSF13B, 
               
               
                   
                   
                 CX3CR1, CD52, CCR1, ABMD2, MARCH1, PSD3, LILRB2, 
               
               
                   
                   
                 PCDHGA12, SLC7A11, TLR4, GCNT1, AQP1, GBP5, 
               
               
                   
                   
                 CALHM2, C3AR1, TRPM8, NRP1, SLC6A6, HAVCR2, 
               
               
                   
                   
                 POPDC3, PTPRO, IFNGR1, PTGS1, FADS3, GBP3, 
               
               
                   
                   
                 C4ORF34, NRCAM, UGCG, ADAMDEC1, KMO, APBB1IP, 
               
               
                   
                   
                 ITGB5, PSD3, ICAM1, GCNT1, ATP1B1, GLIPR1, IL10RA, 
               
               
                   
                   
                 SLC37A2, CD180, SLC43A2, NRP2, SYTL1, ST3GAL5, 
               
               
                   
                   
                 ATP9A, CYP1B1, DAPP1, DAB2, CD109, GLIPR1, EVL, 
               
               
                   
                   
                 CD36, TMEM39A, ADORA3, DSE, ATP6V0D2, PTRF, 
               
               
                   
                   
                 PCDH7, NT5E, APBB1IP, STEAP1, TMEM158, SLC41A2, 
               
               
                   
                   
                 LPAR6, LOC100131909, HMOX1, CYP1B1, CALHM2, 
               
               
                   
                   
                 AQP1, DAB2, GBP2, NRP1, SLAMF8, ABCC3, TM7SF4, 
               
               
                   
                   
                 SLC7A11, TNFRSF21, PLA2G4A, LPCAT2, TNFSF13B, 
               
               
                   
                   
                 ABHD2, TBXAS1, PTRF, DOCK4, MCOLN3, THBD, TLR4, 
               
               
                   
                   
                 SUCNR1, P2RY14, KMO, CLEC7A, ENPP2, LFNG, ABCB1, 
               
               
                   
                   
                 EMP1, PTGS1, FN1, GDPD1, FN1, RAB27B, EPS8, DIXDC1, 
               
               
                   
                   
                 IL7R, CD52, PARM1, PTAFR, CNIH3, CD86, IL27RA, 
               
               
                   
                   
                 CXCR7, IL2RG, SLAMF8, ANKH, RAPH1, MMP14, 
               
               
                   
                   
                 GPR183, ABHD2, CKLF, C4ORF34, SLC41A2, MDGA1, 
               
               
                   
                   
                 ALCAM, HAVCR2, CYP1B1, RAPH1, TLR4, GPR35, ITGB7, 
               
               
                   
                   
                 ADORA3, THBD, SLC41A2, DAB2, OLR1, MCOLN3, DAB2, 
               
               
                   
                   
                 CD36, TREM1, ALCAM 
               
               
                   
                 GO: 0016021~integral to 
                 PAQR5, CD44, MFI2, NRP1, CD36, ADORA3, SLAMF7, 
               
               
                   
                 membrane 
                 PCDHGA12, IL7R, AGPAT9, ATP10A, PAQR5, GDPD1, 
               
               
                   
                   
                 KCNQ3, GLDN, IFNGR1, MPZL3, ABHD2, EMR2, GCNT1, 
               
               
                   
                   
                 CD244, SLC43A2, FADS3, CYBB, RHBDF1, LILRB1, ABHD2, 
               
               
                   
                   
                 SLC38A6, C4ORF34, CSF1R, CXCR7, GPC1, CD36, CD9, 
               
               
                   
                   
                 ATP1B1, TNFRSF21, THBD, ACPP, CSPG4, ABHD2, 
               
               
                   
                   
                 IFNGR1, TLR4, SLC12A6, TNFSF13B, CX3CR1, CD52, 
               
               
                   
                   
                 CCR1, ABHD2, MARCH1, LILRB2, PCDHGA12, SLC7A11, 
               
               
                   
                   
                 TLR4, GCNT1, AQP1, CALHM2, C3AR1, TRPM8, NRP1, 
               
               
                   
                   
                 SLC6A6, HAVCR2, POPDC3, IFNGR1, PTPRO, FADS3, 
               
               
                   
                   
                 GBP3, C4ORF34, NRCAM, UGCG, ADAMDEC1, KMO, 
               
               
                   
                   
                 ITGB5, ICAM1, GCNT1, ATP1B1, GLIPR1, IL10RA, 
               
               
                   
                   
                 SLC37A2, CD180, SLC43A2, NRP2, ST3GAL5, ATP9A, 
               
               
                   
                   
                 GLIPR1, CD36, TMEM39A, ADORA3, DSE, PCDH7, 
               
               
                   
                   
                 STEAP1, TMEM158, LPAR6, SLC41A2, LOC100131909, 
               
               
                   
                   
                 AQP1, CALHM2, NRP1, SLAMF8, ABCC3, TM7SF4, 
               
               
                   
                   
                 SLC7A11, TNFRSF21, PLA2G4A, LPCAT2, TNFSF13B, 
               
               
                   
                   
                 ABHD2, TBXAS1, MCOLN3, THBD, TLR4, SUCNR1, 
               
               
                   
                   
                 P2RY14, KMO, CLEC7A, ENPP2, LFNG, ABCB1, EMP1, 
               
               
                   
                   
                 GDPD1, EPS8, IL7R, CD52, PARM1, PTAFR, CNIH3, CD86, 
               
               
                   
                   
                 IL27RA, CXCR7, IL2RG, SLAMF8, ANKH, MMP14, 
               
               
                   
                   
                 GPR183, ABHD2, CKLF, C4ORF34, SLC41A2, HAVCR2, 
               
               
                   
                   
                 ALCAM, TLR4, GPR35, ITGB7, ADORA3, THBD, SLC41A2, 
               
               
                   
                   
                 OLR1, MCOLN3, CD36, TREM1, ALCAM 
               
               
                   
                 GO: 0044421~extracellular 
                 THBD, CD44, FN1, FN1, MMP2, VEGFA, ANXA2P1, 
               
               
                   
                 region part 
                 MMP19, CCL5, ANXA2P1, FN1, TNFSF13B, CD109, IL10, 
               
               
                   
                   
                 FGL2, MMP9, HMCN1, VEGFA, MMP14, CCL24, CD109, 
               
               
                   
                   
                 VEGFA, MMP1, CKLF, GNLY, HMOX1, COL6A1, A2M, 
               
               
                   
                   
                 ADAMTS15, ANXA2P2, CCL5, VEGFA, ANXA2P1, 
               
               
                   
                   
                 SERPINE2, TNFSF13B, THBD, IGFBP3, THBD, GPC1, FGL2, 
               
               
                   
                   
                 GNLY, COL22A1, CCL5, VASH1, IGFBP3, ICAM1, FN1 
               
               
                   
                 GO: 0004888~transmembrane 
                 THBD, IL10RA, NRP1, CD36, ADORA3, IFNGR1, TLR4, 
               
               
                   
                 receptor activity 
                 NRP2, IL7R, CX3CR1, CCR1, PTAFR, IL7R, CD36, IL27RA, 
               
               
                   
                   
                 IL2RG, CXCR7, ADORA3, HMCN1, TLR4, GPR183, 
               
               
                   
                   
                 IFNGR1, LPAR6, C3AR1, LOC100131909, EMR2, NRP1, 
               
               
                   
                   
                 NRP1, GPR35, TLR4, PTPRO, IFNGR1, ADORA3, THBD, 
               
               
                   
                   
                 CSF1R, CXCR7, THBD, TLR4, SUCNR1, OLR1, CD36, 
               
               
                   
                   
                 P2RY14, ENPP2, CD36, ICAM1 
               
               
                   
                 GO: 0006955~immune 
                 FTHL3, OAS1, VEGFA, OAS1, CCL5, TLR4, CD180, 
               
               
                   
                 response 
                 SLAMF7, IL7R, TNFSF13B, CCR1, PTAFR, IL7R, CD86, 
               
               
                   
                   
                 IL27RA, IL2RG, IL10, LILRB2, VEGFA, TLR4, CCL24, NOD2, 
               
               
                   
                   
                 GPR183, VEGFA, GBP5, GBP2, CCL5, VEGFA, TLR4, CYBB, 
               
               
                   
                   
                 LILRB1, TNFSF13B, PTX3, GBP3, TLR4, OLR1, P2RY14, 
               
               
                   
                   
                 CLEC7A, CCL5, ENPP2, TREM1, GBP2, ICAM1, TRIM22 
               
               
                   
                 GO: 0009611~response 
                 FN1, CD44, NRP1, CD36, ADORA3, CD180, CD36 
               
               
                   
                 to wounding 
                 ADORA3, ABHD2, HMOX1, NRP1, CYBB, ABHD2, PTX3, 
               
               
                   
                   
                 ABHD2, TLR4, THBD, CD36, CLEC7A, CD9, PAPSS2, FN1, 
               
               
                   
                   
                 THBD, FN1, ABHD2, CCL5, TLR4, FN1, CX3CR1, CCR1, 
               
               
                   
                   
                 PTAFR, ABHD2, IL10, MGLL, HMCN1, CCL24, ABHD2, 
               
               
                   
                   
                 TLR4, IRF7, INA, C3AR1, A2M, NRP1, CCL5, NLRC4, TLR4, 
               
               
                   
                   
                 THBD, ADORA3, OLR1, CCL5, CD36 
               
               
                   
                 GO: 0009605~response 
                 CD44, FN1, NRP1, CD36, ADORA3, CD180, NRP2, CD36, 
               
               
                   
                 to external stimulus 
                 ADORA3, CDKN1A, NOD2, ABHD2, HMOX1, 
               
               
                   
                   
                 LOC100131909, NRP1, CYBB, PLA2G4A, PTX3, ABHD2, 
               
               
                   
                   
                 ABHD2, TLR4, THBD, CD36, CLEC7A, ENPP2, PAPSS2, 
               
               
                   
                   
                 CD9, FN1, THBD, FN1, ABHD2, CCL5, TLR4, FN1, CX3CR1, 
               
               
                   
                   
                 CCR1, PTAFR, ABHD2, IL10, MGLL, HMCN1, MMP14, 
               
               
                   
                   
                 IRF7, CCL24, ABHD2, TLR4, CKLF, INA, C3AR1, A2M, 
               
               
                   
                   
                 NRP1, CCL5, NLRC4, TLR4, ADORA3, THBD, CCND1, 
               
               
                   
                   
                 OLR1, CCL5, CD36 
               
               
                   
                 GO: 0002376~immune 
                 OAS1, OAS1, CD180, SLAMF7, IL7R, MMP9, NOD2, 
               
               
                   
                 system process 
                 EPAS1, GBP2, ID2, TM7SF4, CYBB, LILRB1, TNFSF13B, 
               
               
                   
                   
                 BCL6, PTX3, IFI30, TLR4, P2RY14, CLEC7A, ENPP2, GBP2, 
               
               
                   
                   
                 TRIM22, FTHL3, VEGFA, CCL5, ID2, TLR4, IL7R, 
               
               
                   
                   
                 TNFSF13B, CCR1, PTAFR, CD86, IL27RA, IL2RG, IL10, 
               
               
                   
                   
                 LILRB2, VEGFA, CCL24, GPR183, TLR4, VEGFA, GBP5, 
               
               
                   
                   
                 CKLF, C3AR1, BCL6, CCL5, VEGFA, TLR4, CRIP2, ID2, 
               
               
                   
                   
                 GBP3, OLR1, CCL5, TREM1, ICAM1 
               
               
                   
                 GO: 0050896~response 
                 FN1, CD44, OAS1, NRP1, CD36, CYP1B1, ADORA3, 
               
               
                   
                 to stimulus 
                 SLAMF7, IL7R, EEPD1, CDKN1A, IFNGR1, ABHD2, ID2, 
               
               
                   
                   
                 CYBB, LILRB1, BCL6, ABHD2, GNLY, CD36, CD9, PAPSS2, 
               
               
                   
                   
                 ATP1B1, GBP2, PLIN2, TRIM22, PTGS1, FTHL3, THBD, 
               
               
                   
                   
                 VEGFA, ABHD2, IFNGR1, CCL5, TLR4, ID2, FN1, 
               
               
                   
                   
                 TNFSF138, CX3CR1, ME1, CCR1, ABHD2, IL10, LILRB2, 
               
               
                   
                   
                 HMCN1, SLC7A11, AQP1, CCL24, TLR4, IRF7, GBP5, 
               
               
                   
                   
                 C3AR1, RASGRF1, TRPM8, A2M, ME1, NRP1, VEGFA, 
               
               
                   
                   
                 IFNGR1, PTGS1, GBP3, EEPD1, HIPK2, KMO, ICAM1, 
               
               
                   
                   
                 ATP1B1, MMP2, OAS1, FGD4, CD180, NRP2, CYP1B1, 
               
               
                   
                   
                 CD36, ADORA3, NOD2, EPAS1, GNLY, LOC100131909, 
               
               
                   
                   
                 HMOX1, CYP1B1, AQP1, IFI44, GBP2, NRP1, SLC7A11, 
               
               
                   
                   
                 PLA2G4A, PTX3, TNFSF13B, ABHD2, MCOLN3, TLR4, 
               
               
                   
                   
                 THBD, P2RY14, KMO, CLEC7A, ENPP2, ABCB1, PTGS1, 
               
               
                   
                   
                 FN1, FN1, EPS8, IL7R, HSPB7, PTAFR, CD86, IL27RA, 
               
               
                   
                   
                 IL2RG, MGLL, VEGFA, ANKH, MMP14, ABHD2, GPR183, 
               
               
                   
                   
                 VEGFA, CKLF, INA, BCL6, FABP4, CCL5, NLRC4, CYP1B1, 
               
               
                   
                   
                 FGD4, TLR4, ID2, THBD, ADORA3, CCND1, OLR1, 
               
               
                   
                   
                 MCOLN3, CCL5, CD36, TREM1 
               
               
                   
                 GO: 00322501~multicellular 
                 ADAP2, PAQR5, CD44, NRP1, CD36, CYP1B1, LBH, IL7R, 
               
               
                   
                 organismal process 
                 KCNQ3, MMP9, PAQR5, MAF, GLDN, CDKN1A, MPZL3, 
               
               
                   
                   
                 PDLIM7, ID2, ANXA2P1, TFAP2A, ATF5, MITF, BCL6, 
               
               
                   
                   
                 CSF1R, CKB, CD36, NGEF, CD9, PAPSS2, IGFBP3, PTGS1, 
               
               
                   
                   
                 THBD, CSPG4, VEGFA, TLR4, ID2, PRDM1, SLC12A6, 
               
               
                   
                   
                 TRPS1, STATH, IL10, HMCN1, MAFB, AQP1, TLR4, 
               
               
                   
                   
                 C3AR1, RASGRF1, TRPM8, NRP1, VEGFA, SKIL, PTGS1, 
               
               
                   
                   
                 NRCAM, ARI05B, UGCG, HIPK2, MMP2, TRPS1, NRP2, 
               
               
                   
                   
                 CYP1B1, DAB2, CD36, EVL, ZFP36L1, NOD2, EPAS1, 
               
               
                   
                   
                 TUBB2A, LOC100131909, HMOX1, CYP1B1, AQP1, 
               
               
                   
                   
                 DAB2, ATF5, ANXA2P2, NRP1, TM7SF4, CDK5RAP2, 
               
               
                   
                   
                 PLA2G4A, SERPINE2, IGFBP3, LMNA, MCOLN3, TLR4, 
               
               
                   
                   
                 THBD, CLEC7A, LFNG, TRPS1, AHNAK, PGA5, EMP1, 
               
               
                   
                   
                 PTGS1, ANXA2P1, MMP19, NGEF, ANXA2P1, EPS8, 
               
               
                   
                   
                 DIXDC1, IL7R, TPRS1, MAFB, PTAFR, MITF, NPTX1, 
               
               
                   
                   
                 VEGFA, ANKH, MMP14, GPR183, MMP1, VEGFA, INA, 
               
               
                   
                   
                 BCL6, MDGA1, PDLIM7, ALCAM, FABP4, CDK5RAP2, 
               
               
                   
                   
                 NLRC4, CYP1B1, TLR4, CRIP2, ID2, THBD, CCND1, DAB2, 
               
               
                   
                   
                 ADAP2, OLR1, MCOLN3, DAB2, CD36, ALCAM 
               
               
                   
                 GO: 0050793~regulation 
                 FN1, NRP1, CD36, FGD4, IL7R, CD36, ATP10A, MAF, 
               
               
                   
                 of developmental 
                 PDLIM7, HMOX1, LOC100131909, ATF5, ID2, NRP1, 
               
               
                   
                 process 
                 CDK5RAP2, ATF5, MITF, PLA2G4A, BCL6, IGFBP3, FGD2, 
               
               
                   
                   
                 TLR4, CD36, IGFBP3, FN1, FN1, VEGFA, FGD2, CCL5, ID2, 
               
               
                   
                   
                 TLR4, FN1, IL7R, MAFB, MITF, CD86, STATH, IL27RA, 
               
               
                   
                   
                 IL2RG, IL10, VEGFA, ANKH, MAFB, TLR4, VEGFA, BCL6, 
               
               
                   
                   
                 PDLIM7, CDK5RAP2, NRP1, CCL5, VEGFA, FGD4, FGD2, 
               
               
                   
                   
                 TLR4, ID2, FGD2, CCND1, NRCAM, CCL5, VASH1, CD36 
               
               
                   
                 GO: 0009897~external 
                 CD44, TRPM8, CSPG4, ALCAM, CD244, TLR4, TLR4, IL7R, 
               
               
                   
                 side of plasma 
                 IL7R, NRCAM, CD86, IL2RG, TLR4, GPC1, CLEC7A, TLR4, 
               
               
                   
                 membrane 
                 ALCAM, ICAM1 
               
               
                   
                 GO: 0051239~regulation 
                 NRP1, ADORA3, IL7R, ADORA3, MAF, NOD2, EPAS1, 
               
               
                   
                 of multicellular 
                 PDLIM7, HMOX1, LOC100131909, ATF5, ANXA2P2, ID2, 
               
               
                   
                 organismal process 
                 NRP1, ANXA2P1, CDK5RAP2, ATF5, MITF, PLA2G4A, 
               
               
                   
                   
                 BCL6, IGFBP3, TLR4, CLEC7A, PTGS1, IGFBP3, PTGS1, 
               
               
                   
                   
                 VEGFA, ANXA2P1, CCL5, ID2, ANXA2P1, TLR4, IL7R, 
               
               
                   
                   
                 HSPB7, MAFB, MITF, CD86, STATH, IL27RA, IL2RG, IL10, 
               
               
                   
                   
                 VEGFA, ANKH, MAFB, TLR4, VEGFA, RASGRF1, BCL6, 
               
               
                   
                   
                 PDLIM7, CDK5RAP2, NRP1, CCL5, VEGFA, TLR4, ID2, 
               
               
                   
                   
                 PTGS1, ADORA3, NRCAM, CCND1, CCL5, VASH1 
               
               
                   
                 GO: 0006952~defense 
                 CD44, FN1, FN1, ADORA3, CCL5, TLR4, CD180, FN1, 
               
               
                   
                 response 
                 SLAMF7, CX3CR1, CCR1, PTAFR, IL27RA, ADORA3, IL10, 
               
               
                   
                   
                 MGLL, LILRB2, IRF7, TLR4, CCL24, NOD2, GNLY, C3AR1, 
               
               
                   
                   
                 HMOX1, LOC100131909, A2M, CCL5, NLRC4, TLR4, 
               
               
                   
                   
                 CYBB, PTX3, ADORA3, OLR1, TLR4, GNLY, CLEC7A, CCL5, 
               
               
                   
                   
                 FN1 
               
               
                   
                 GO: 0006954~inflammatory 
                 FN1, FN1, CD44, ADORA3, CCL5, CD180, TLR4, FN1, 
               
               
                   
                 response 
                 CCR1, PTAFR, MGLL, ADORA3, IL10, TLR4, CCL24, IRF7, 
               
               
                   
                   
                 C3AR1, HMOX1, A2M, CCL5, NLRC4, TLR4, CYBB, PTX3, 
               
               
                   
                   
                 ADORA3, TLR4, OLR1, CLEC7A, CCL5, FN1 
               
               
                   
                 GO: 0031012~extracellular 
                 CD44, FN1, FN1, MMP2, COLGA1, VEGFA, ANXA2P1, 
               
               
                   
                 matrix 
                 MMP19, ANXA2P2, ADAMTS15, VEGFA, ANXA2P1, 
               
               
                   
                   
                 ANXA2P1, FN1, GPC1, COL22A1, MMP9, HMCN1, 
               
               
                   
                   
                 VEGFA, MMP14, VEGFA, MMP1, FN1 
               
               
                   
                 GO: 0048583~regulation 
                 NT5E, VEGFA, ANXA2P1, FGD4, CCL5, ANXA2P1, TLR4, 
               
               
                   
                 of response to stimulus 
                 IL7R, TMFSF13B, IL7B, CD86, IL27RA, IL10, VEGFA, 
               
               
                   
                   
                 NOD2, TLR4, IRF7, VEGFA, NT5E, C3AR1, HMOX1, 
               
               
                   
                   
                 LOC100131909, BCL6, A2M, FABP4, ANXA2P2, CCL5, 
               
               
                   
                   
                 VEGFA, FGD4, AMXA2P1, TLR4, PLA2G4A, TNFSF138, 
               
               
                   
                   
                 BCL6, TLR4, HIPK2, CLEC7A, CCL5, ICAM1 
               
               
                   
                 GO: 0005578~proteinaceous 
                 FN1, FN1, MMP2, COL6A1, VEGFA, ANXA2P1, MMP19, 
               
               
                   
                 extracellular matrix 
                 ANXA2P2, ADAMTS15, VEGFA, ANXA2P1, ANXA2P1, 
               
               
                   
                   
                 FN1, GPC1, COL22A1, MMP9, HMCN1, VEGFA, MMP14, 
               
               
                   
                   
                 VEGFA, MMP1, FN1 
               
               
                   
                 GO: 0009986~cell surface 
                 CD44, CSPG4, VEGFA, CD36, TLR4, IL7R, IL7R, CD36, 
               
               
                   
                   
                 CD86, IL2RG, VEGFA, NOD2, TLR4, VEGFA, TRPM8, 
               
               
                   
                   
                 ALCAM, CD244, VEGFA, TM7SF4, TLR4, NRCAM, TLR4, 
               
               
                   
                   
                 GPC1, CD36, CLEC7A, CD36, ABCB1, ALCAM, ICAM1 
               
               
                   
                 GO: 0002682~regulation 
                 CD44, VEGFA, CCL5, ID2, TLR4, IL7R, TNFSF13B, MAFB, 
               
               
                   
                 of immune system 
                 IL7R, MITF, CD86, IL27RA, IL2RG, IL10, VEGFA, CDKN1A, 
               
               
                   
                 process 
                 MAFB, NOD2, TLR4, VEGFA, C3AR1, HMOX1, 
               
               
                   
                   
                 LOC100131909, BCL6, A2M, CCL5, VEGFA, ID2, TLR4, 
               
               
                   
                   
                 MITF, TNFSF13B, ID2, BCL6, TLR4, CLEC7A, CCL5, ICAM1 
               
               
                   
                 GO: 0005615~extracellular 
                 THBD, FN1, FN1, MMP2, VEGFA, CCL5, FN1, TNFSF13B, 
               
               
                   
                 space 
                 CD109, IL10, FGL2, MMP9, VEGFA, CD109, CCL24, 
               
               
                   
                   
                 VEGFA, CKLF, GNLY, HMOX1, A2M, CCL5, VEGFA, 
               
               
                   
                   
                 SERPINE2, TNFSF13B, IGFBP3, THBD, THBD, GPC1, 
               
               
                   
                   
                 GNLY, FGL2, CCL5, VASH1, IGFBP3, ICAM1, FN1 
               
               
                   
                 GO: 0048731~system 
                 ADAP2, CD44, MMP2, NRP1, TRPS1, NRP2, IL7R, EVL, 
               
               
                   
                 development 
                 ZFP36L1, MAF, MMP9, CDKN1A, GLDN, EPAS1, TUBB2A, 
               
               
                   
                   
                 PDLIM7, HMOX1, ATF5, ANXA2P2, ID2, NRP1, ANXA2P1, 
               
               
                   
                   
                 TM7SF4, CDXSRAP2, ATF5, TFAP2A, PLA2G4A, MITF, 
               
               
                   
                   
                 SERPINE2, BCL6, IGFBP3, LMNA, MCOLN3, CKB, LFNG, 
               
               
                   
                   
                 NGEF, PAPSS2, CD9, TRPS1, AHNAK, IGFBP3, EMP1, 
               
               
                   
                   
                 ANXA2P1, CSPG4, VEGFA, MMP19, NGEF, ID2, 
               
               
                   
                   
                 ANXA2P1, PRDM1, IL7R, TRPS1, MAFB, MITF, STATH, 
               
               
                   
                   
                 TRPS1, NPTX1, IL10, MMP14, ANKH, MAFB, VEGFA, 
               
               
                   
                   
                 GPR183, VEGFA, INA, RASGRF1, BCL6, MDGA1, PDLIM7, 
               
               
                   
                   
                 ALCAM, CDK5RAP2, NRP1, VEGFA, CRIP2, ID2, NRCAM, 
               
               
                   
                   
                 CCND1, ARIDSB, UGCG, ADAP2, MCOLN3, ALCAM 
               
               
                   
                 GO: 0051707~response 
                 THBD, CCL5, IFNGR1, TLR4, PTAFR, IL27RA, IL10, TLR4, 
               
               
                   
                 to other organism 
                 NOD2, IRF7, IFNGR1, GNLY, IFI44, CCL5, NLRC4, TLR4, 
               
               
                   
                   
                 IFNGR1, LILRB1, PLA2G4A, PTX3, THBD, TLR4, THBD, 
               
               
                   
                   
                 GNLY, CLEC7A, CCL5, TRIM22 
               
               
                   
                 GO: 0007275~multicellular 
                 PAQR5, ADAP2, CD44, MMP2, NRP1, TRPS1, LBH, NRP2, 
               
               
                   
                 organismal 
                 DAB2, IL7R, EVL, ZFP36L1, MAF, PAQR5, MMP9, 
               
               
                   
                 development 
                 CDKN1A, GLDN, EPAS1, TUBB2A, PDLIM7, HMOX1, 
               
               
                   
                   
                 DAB2, ATF5, ANXA2P2, ID2, NRP1, ANXA2P1, TM7SF4, 
               
               
                   
                   
                 CDK5RAP2, ATF5, TFAP2A, PLA2G4A, MITF, SERPINE2, 
               
               
                   
                   
                 BCL6, IGFBP3, CSF1R, LMNA, MCOLN3, CKB, THBD, 
               
               
                   
                   
                 LFNG, NGEF, PAPSS2, CD9, TRPS1, AHNAK, IGFBP3, 
               
               
                   
                   
                 EMP1, THBD, VEGFA, ANXA2P1, CSPG4, MMP19, NGEF, 
               
               
                   
                   
                 ID2, ANXA2P1, PRDM1, DIXDC1, IL7R, TRPS1, MAFB, 
               
               
                   
                   
                 MITF, STATH, TRPS1, NPTX1, IL10, MMP14, ANKH, 
               
               
                   
                   
                 VEGFA, MAFB, GPR183, VEGFA, INA, RASGRF1, BCL6, 
               
               
                   
                   
                 MDGA1, PDLIM7, ALCAM, CDK5RAP2, NRP1, VEGFA, 
               
               
                   
                   
                 CRIP2, SKIL, ID2, THBD, NRCAM, CCND1, ARID5B, UGCG, 
               
               
                   
                   
                 DAB2, ADAP2, HIPK2, MCOLN3, DAB2, ALCAM 
               
               
                   
                 GO: 0032101~regulation 
                 NT5E, LOC100131909, BCL6, VEGFA, ANXA2P1, A2M, 
               
               
                   
                 of response to external 
                 FABP4, ANXA2P2, CCL5, CCL5, VEGFA, TLR4, ANXA2P1, 
               
               
                   
                 stimulus 
                 AMXA2P1, TLR4, PLA2G4A, BCL6, TLR4, IL10, VEGFA, 
               
               
                   
                   
                 CCL5, TLR4, VEGFA, NT5E 
               
               
                   
                 GO: 0022610~biological 
                 CD44, FN1, FN1, NRP1, CD36, CCL5, FN1, SLAMF7, 
               
               
                   
                 adhesion 
                 MTSS1, NRP2, PCDHGA12, CX3CR1, CCR1, CD36, 
               
               
                   
                   
                 PCDHGA12, RAPH1, PCDH7, MPZL3, COL6A1, ALCAM, 
               
               
                   
                   
                 CCL5, NRP1, RAPH1, NRP1, MTSS1, ITGB7, LPXN, 
               
               
                   
                   
                 NRCAM, OLR1, CD36, CLEC7A, COL22A1, CCL5, CD36, 
               
               
                   
                   
                 ITGB5, CD9, ALCAM, ICAM1, FN1 
               
               
                   
                 GO: 0007155~cell 
                 CD44, FN1, FN1, NRP1, CD36, CCL5, FN1, SLAMF7, 
               
               
                   
                 adhesion 
                 MTSS1, NRP2, PCDHGA12, CX3CR1, CCR1, CD36, 
               
               
                   
                   
                 PCDHGA12, RAPH1, PCDH7, MPZL3, COL6A1, ALCAM, 
               
               
                   
                   
                 CCL5, NRP1, RAPH1, NRP1, MTSS1, ITG87, LPXN, 
               
               
                   
                   
                 NRCAM, OLR1, CD36, CLEC7A, COL22A1, CCL5, CD36, 
               
               
                   
                   
                 ITGB5, CD9, ALCAM, ICAM1, FN1 
               
               
                   
                 GO: 0048856~anatomical 
                 ADAP2, FN1, CD44, MMP2, NRP1, TRPS1, NRP2, DAB2, 
               
               
                   
                 structure development 
                 IL7R, EVL, ZFP36L1, MAF, MMP9, CDKN1A, GLDN, 
               
               
                   
                   
                 EPAS1, TUB82A, PDLIM7, HMOX1, DAB2, ATF5, 
               
               
                   
                   
                 ANXA2P2, ID2, NRP1, ANXA2P1, TM7SF4, CDK5RAP2, 
               
               
                   
                   
                 ATF5, TFAP2A, PLA2G4A, MITF, SERPINE2, BCL6, IGFBP3, 
               
               
                   
                   
                 LMNA, MCOLN3, CKB, LFNG, NGEF, PAPSS2, CD9, TRPS1, 
               
               
                   
                   
                 AHNAX, IGFBP3, EMP1, FN1, FN1, ANXA2P1, CSPG4, 
               
               
                   
                   
                 VEGFA, MMP19, HGEF, ID2, ANXA2P1, PRDM1, FN1, 
               
               
                   
                   
                 IL7B, TRPS1, MAFB, MITF, STATH, TRPS1, NPTX1, IL10, 
               
               
                   
                   
                 MMP14, ANKH, MAFB, VEGFA, GPR183, VEGFA, INA, 
               
               
                   
                   
                 RASGRF1, BCL6, MDGA1, PDLIM7, ALCAM, CDK5RAP2, 
               
               
                   
                   
                 NRP1, VEGFA, CRIP2, ID2, NRCAM, CCND1, ARID5B, 
               
               
                   
                   
                 UGCG, DAB2, ADAP2, MCOLN3, DAB2, ALCAM 
               
               
                   
                 GO: 0065008~regulation 
                 MFI2, FN1, NRP1, CD36, CYP1B1, FGD4, IL7R, DAB2, 
               
               
                   
                 of biological quality 
                 CYP1B1, CD36, ATP10A, CDKN1A, EPAS1, HMOX1, 
               
               
                   
                   
                 LOC100131909, CYP181, DAB2, ANXA2P2, ID2, NRP1, 
               
               
                   
                   
                 ANXA2P1, PLA2G4A, TNFSF13B, BCL6, CKB, FGD2, THBD, 
               
               
                   
                   
                 TLR4, IFI30, CD36, PAPSS2, CD9, FTGS1, EMP1, PTGS1, 
               
               
                   
                   
                 FN1, FTHL3, THBD, FN1, VEGFA, ANXA2P1, FGD2, CCL5, 
               
               
                   
                   
                 TLR4, ID2, ANXA2P1, FN1, SLC12A6, IL7R, TNFSF13B, 
               
               
                   
                   
                 CD52, CD52, CCR1, STATH, IL10, HMCN1, VEGFA, IRF7, 
               
               
                   
                   
                 TLR4, VEGFA, C3AR1, RASGRF1, BCL6, TRPM8, FABP4, 
               
               
                   
                   
                 CCL5, NRP1, VEGFA, CYP1B1, FGD4, FGD2, TLR4, ID2, 
               
               
                   
                   
                 THBD, PTGS1, FGD2, DAB2, CCL5, CD36, DAB2, SERTAD1 
               
               
                   
                 GO: 0007166~cell surface 
                 NRP1, ADORA3, MTSS1, MAML3, IL7R, EVL, ADORA3, 
               
               
                   
                 receptor linked signal 
                 MAML2, LPAR6, LOC100131909, EMR2, NRP1, MAML2, 
               
               
                   
                 transduction 
                 MITF, CSF1R, CXCR7, SUCNR1, P2RY14, CLEC7A, ENPP2, 
               
               
                   
                   
                 VEGFA, CCL5, MAML2, EPS8, DIXDC1, IL7R, CK3CR1, 
               
               
                   
                   
                 CCR1, PTAFR, MITF, IL27RA, CXCR7, LILRB2, VEGFA, 
               
               
                   
                   
                 GPR183, VEGFA, MAML2, C3AR1, MAML2, NRP1, CCL5, 
               
               
                   
                   
                 VEGFA, DOK2, MTSS1, GPR35, ITGB7, ADORA3, CCND1, 
               
               
                   
                   
                 ARID5B, RGS13, ADAMDEC1, HIPK2, CCL5, ITGB5 
               
               
                   
                 GO: 0050727~regulation 
                 NT5E, BCL6, LOC100131909, A2M, FABP4, CCL5, CCL5, 
               
               
                   
                 of inflammatory 
                 TLR4, TLR4, PLA2G4A, BCL6, TLR4, IL10, CCL5, TLR4, 
               
               
                   
                 response 
                 NT5E 
               
               
                   
                 GO: 0006950~response 
                 FN1, CD44, MMP2, NRP1, CD36, FGD4, ADORA3, CD180, 
               
               
                   
                 to stress 
                 SLAMF7, CD36, ADORA3, CDKN1A, EEPD1, NOD2, 
               
               
                   
                   
                 EPA51, GNLY, ABHD2, HMOX1, LOC100131909, NRP1, 
               
               
                   
                   
                 CYBB, PLA2G4A, BCL6, ABHD2, PTX3, ABHD2, TLR4, 
               
               
                   
                   
                 THBD, GNLY, CD36, KMO, CLEC7A, CD9, PAPSS2, 
               
               
                   
                   
                 ATP1B1, PTGS1, FN1, PTGS1, THBD, FN1, VEGFA, 
               
               
                   
                   
                 ABHD2, CCL5, TLR4, FN1, HSPB7, CX3CR1, CCR1, PTAFR, 
               
               
                   
                   
                 ABHD2, IL27RA, MGU, IL10, LILRB2, HMCN1, MMP14, 
               
               
                   
                   
                 VEGFA, CCL24, ABHD2, TLR4, IRF7, VEGFA, INA, C3AR1, 
               
               
                   
                   
                 BCL6, TRPM8, A2M, NRP1, CCL5, NLRC4, FGD4, VEGFA, 
               
               
                   
                   
                 TLR4, PTGS1, THBD, ADORA3, CCND1, OLR1, EEPD1, 
               
               
                   
                   
                 HIPK2, KMO, CCL5, CD36, ATP1B1 
               
               
                   
                 GO: 0032502~developmental 
                 ADAP2, PAQR5, CD44, FN1, NRP1, LBH, IL7R, MMP9, 
               
               
                   
                 process 
                 PAQRS, MAF, GLDN, CDKN1A, PDLIM7, ID2, ANXA2P1, 
               
               
                   
                   
                 TFAP2A, ATF5, MITF, BCL6, CSF1R, CKB, NGEF, CD9, 
               
               
                   
                   
                 PAPSS2, IGFBP3, PTGS1, THBD, CSPG4, VEGFA, CCL5, 
               
               
                   
                   
                 ID2, FN1, PRDM1, TRPS1, STATH, IL10, MAFB, RASGRF1, 
               
               
                   
                   
                 NRP1, VEGFA, SKIL, PTGS1, ARID5B, NRCAM, UGCG, 
               
               
                   
                   
                 HIPK2, MMP2, TRPS1, NRP2, DAB2, EVL, ZFP36L1, 
               
               
                   
                   
                 EPAS1, TUBB2A, HMOX1, DAB2, ATFS, ANXA2P2, NRP1, 
               
               
                   
                   
                 TM7SF4, CDK5RAP2, SERPINE2, PLA2G4A, IGFBP3, 
               
               
                   
                   
                 LMNA, MCOLN3, THBD, LFNG, TRPS1, AHNAK, EMP1, 
               
               
                   
                   
                 PTGS1, FN1, FN1, ANXA2P1, MMP19, NGEF, ANXA2P1, 
               
               
                   
                   
                 DIXDC1, IL7R, TRPS1, MAFB, MITF, NPTX1, VEGFA, 
               
               
                   
                   
                 ANKH, MMP14, GPR183, VEGFA, INA, BCL6, MDGA1, 
               
               
                   
                   
                 PDLIM7, ALCAM, FABP4, CDK5RAP2, CCL5, CRIP2, ID2, 
               
               
                   
                   
                 THBD, CCND1, ADAP2, DAB2, MCOLN3, CCL5, DAB2, 
               
               
                   
                   
                 ALCAM 
               
               
                   
                 GO: 0031347~regulation 
                 NT5E, LOC10013I909, BCL6, A2M, FABP4, CCL5, CCL5, 
               
               
                   
                 of defense response 
                 TLR4, TLR4, PLA2G4A, BCL6, TLR4, IL10, CLEC7A, CCL5, 
               
               
                   
                   
                 TLR4, IRF7, NOD2, NT5E 
               
               
                   
                 GO: 0009607~response 
                 THBD, CCL5, IFNGR1, TLR4, HSPB7, PTAFR, IL27RA, IL10, 
               
               
                   
                 to biotic stimulus 
                 TLR4, NOD2, IRF7, IFNGR1, GNLY, IFI44, CCL5, NLRC4, 
               
               
                   
                   
                 IFNGR1, TLR4, LILRB1, PLA2G4A, PTX3, THBD, CCND1, 
               
               
                   
                   
                 TLR4, THBD, GNLY, CLEC7A, CCL5, TRIM22 
               
               
                   
                 GO: 0019955~cytokine 
                 IL10RA, CD36, A2M, IFNGR1, IL7R, IFNGR1, CX3CR1, 
               
               
                   
                 binding 
                 CCR1, IL7R, CSF1R, CD36, IL27RA, IL2RG, CD36, CD36, 
               
               
                   
                   
                 IFNGR1 
               
               
                   
                 GO: 0050776~regulation 
                 C3AR1, HMOX1, LOC100131909, BCL6, A2M, TLR4, 
               
               
                   
                 of immune response 
                 TLR4, IL7R, TNFSF138, TNFSF138, BCL6, IL7R, CD86, 
               
               
                   
                   
                 IL27RA, TLR4, IL10, CLEC7A, NOD2, TLR4, ICAM1 
               
               
                   
                 GO: 0040011~locomotion 
                 FN1, FN1, CD44, NRP1, CCLS, FN1, NRP2, CX3CR1, 
               
               
                   
                   
                 S100A2, CCR1, PTAFR, IL10, MMP14, CCL24, CKLF, 
               
               
                   
                   
                 C3AR1, MDGA1, CCL5, NRP1, NRP1, ARID58, NRCAM, 
               
               
                   
                   
                 CCL5, ENPP2, ICAM1, FN1 
               
               
                   
                 GO: 0080134~regulation 
                 NTSE, ANXA2P1, FGD4, CCLS, ANXA2P1, TLR4, IL10, 
               
               
                   
                 of response to stress 
                 NOD2, TLR4, IRF7, NT5E, BCL6, LOC100131909, A2M, 
               
               
                   
                   
                 FABP4, ANXA2P2, CCL5, FGD4, ANXA2P1, TLR4, 
               
               
                   
                   
                 PLA2G4A, BCL6, TLR4, HIPK2, CLEC7A, CCL5 
               
               
                   
                 GO: 0007626~locomotory 
                 C3AR1, CCL5, CCL5, EPS8, NRP2, CX3CR1, CCR1, PTAFR, 
               
               
                   
                 behavior 
                 MCOLN3, HIPK2, IL10, MCOLN3, ANKH, CCL5, ENPP2, 
               
               
                   
                   
                 CCL24, CKLF 
               
               
                   
                 GO: 0002684~positive 
                 C3AR1, LOC100131909, BCL6, VEGFA, VEGFA, TLR4, 
               
               
                   
                 regulation of immune 
                 IL7R, TLR4, TNFSF13B, TNFSF13B, BCL6, IL7R, CD86, 
               
               
                   
                 system process 
                 IL27RA, IL2RG, TLR4, CLEC7A, VEGFA, CDKN1A, NOD2, 
               
               
                   
                   
                 TLR4, VEGFA, ICAM1 
               
               
                   
                 GO: 0000267~cell 
                 NT5E, OAS1, CD36, CYP1B1, OAS1, SYTL1, PCDHGA12, 
               
               
                   
                 fraction 
                 NRP2, RAB38, CYP1B1, CD36, PTRF, NTSE, HMOX1, 
               
               
                   
                   
                 CYP1B1, FADS3, ANXA2P1, ABCC3, PLA2G4A, TNFSF13B, 
               
               
                   
                   
                 TBXAS1, PTRF, LMNA, CD36, ABCB1, EMP1, PTGS1, 
               
               
                   
                   
                 PTGS1, ANXA2P1, CCL5, ANXA2P1, EPS8, SLC12A6, 
               
               
                   
                   
                 TNFSF13B, ME1, CD52, CD52, PSD3, LILRB2, PCDHGA12, 
               
               
                   
                   
                 RASGRF1, ME1, FABP4, CCL5, CYP1B1, PTGS1, FADS3, 
               
               
                   
                   
                 UGCG, OLR1, CTSL1, CCL5, CD36, PSD3 
               
               
                   
                 GO: 0045028~purinergic 
                 LPAR6, LOC100131909, SUCNR1, P2RY14, ADORA3, 
               
               
                   
                 nudeotide receptor 
                 ADORA3, GPR183, ADORA3 
               
               
                   
                 activity, G-protein 
               
               
                   
                 coupled 
               
               
                   
                 GO: 0001608~nucleotide 
                 LPAR6, LOC100131909, SUCNR1, P2RY14, ADORA3, 
               
               
                   
                 receptor activity, G- 
                 ADORA3, GPR183, ADORA3 
               
               
                   
                 protein coupled 
               
               
                   
                 GO: 0004930~G-protein 
                 LPAR6, C3AR1, LOC100131909, EMR2, ADORA3, GPR35, 
               
               
                   
                 coupled receptor activity 
                 CX3CR1, CCR1, PTAFR, ADORA3, CXCR7, CXCR7, 
               
               
                   
                   
                 SUCNR1, P2RY14, ADORA3, GPR183 
               
               
                   
                 GO: 0016502~nucleotide 
                 LPAR6, LOC100131909, SUCNR1, P2RY14, ADORA3, 
               
               
                   
                 receptor activity 
                 ADORA3, GPR183, ADORA3 
               
               
                   
                 GO: 0001614~purinergic 
                 LPAR6, LOC100131909, SUCNR1, P2RY14, ADORA3, 
               
               
                   
                 nucleotide receptor 
                 ADORA3, GPR183, ADORA3 
               
               
                   
                 GO: 0005626~insoluble 
                 NT5E, OAS1, CD36, OAS1, CYP1B1, EPS8, SLC12A6, 
               
               
                   
                 friction 
                 NRP2, SYTL1, PCDHGA12, CD52, CD52, RAB38, CYP1B1, 
               
               
                   
                   
                 PSD3, CD36, ULRB2, PCDHGA12, PTRF, NT5E, RASGRF1, 
               
               
                   
                   
                 HMOX1, CYP1B1, CYP1B1, FADS3, ABCC3, PLA2G4A, 
               
               
                   
                   
                 PTRF, TBXAS1, PTGS1, FADS3, LMNA, UGCG, OLR1, 
               
               
                   
                   
                 CD36, CD36, PSD3, ABCB1, PTGS1, EMP1, PTGS1 
               
               
                   
                 GO: 0048513~organ 
                 ADAP2, CD44, MMP2, NRP1, NRP2, IL7R, EVL, ZFP36L1, 
               
               
                   
                 development 
                 MMP9, MAF, CDKN1A, EPAS1, HMOX1, ANXA2P2, 
               
               
                   
                   
                 NRP1, ID2, ANXA2P1, TM7SF4, CDK5RAP2, TFAP2A, 
               
               
                   
                   
                 MITF, PLA2G4A, BCL6, LMNA, MCOLN3, CKB, LFNG, 
               
               
                   
                   
                 EMP1, ANXA2P1, CSPG4, VEGFA, MMP19, ANXA2P1, 
               
               
                   
                   
                 ID2, PRDM1, IL7R, MAFB, MITF, STATH, IL10, VEGFA, 
               
               
                   
                   
                 MMP14, MAFB, GPR183, VEGFA, INA, BCL6, MDGA1, 
               
               
                   
                   
                 CDKSRAP2, NRP1, VEGFA, CRIP2, ID2, CCND1, ARID5B, 
               
               
                   
                   
                 UGCG, ADAP2, MCOLN3 
               
               
                   
                 GO: 0002697~regulation 
                 IL7R, HMOX1, LOC100131909, BCL6, IL27RA, A2M, IL10, 
               
               
                   
                 of immune effector 
                 NOD2, IL7R, ICAM1, BCL6 
               
               
                   
                 process 
               
               
                   
                 GO: 0051384~response 
                 CCND1, A2M, FABP4, IL10, CCL5, CCL5, CDKN1A, CCL5, 
               
               
                   
                 to glucocorticoid 
                 PTGS1, PLA2G4A, PTGS1, PTGS1 
               
               
                   
                 stimulus 
               
               
                   
                 GO: 0005624~membrane 
                 NT5E, OAS1, CD36, OAS1, CYP1B1, EPS8, SLC12A6, 
               
               
                   
                 fraction 
                 NRP2, SYTL1, PCDHGA12, CD52, CD52, RAB38, CYP1B1, 
               
               
                   
                   
                 PSD3, CD36, LILRB2, PCDHGA12, PTRF, NT5E, RASGRF1, 
               
               
                   
                   
                 HMOX1, CYP1B1, CYP1B1, FADS3, ABCC3, PLA2G4A, 
               
               
                   
                   
                 PTRF, TBXAS1, PTGS1, FADS3, UGCG, OLR1, CD36, CD36, 
               
               
                   
                   
                 PSD3, ABCB1, PTG51, EMP1, PTGS1 
               
               
                   
                 hsa04060:Cytokine- 
                 TNFRSF21, IL10RA, VEGFA, IFNGR1, CCL5, CCL5, VEGFA, 
               
               
                   
                 cytokine receptor 
                 IFNGR1, IL7R, TNFSF13B, TNFRSF21, CX3CR1, TNFSF13B, 
               
               
                   
                 interaction 
                 CCR1, CSF1R, IL7R, IL2RG, IL10, VEGFA, CCL5, CCL24, 
               
               
                   
                   
                 VEGFA, IFNGR1 
               
               
                   
                 GO: 0031349~positive 
                 LOC100131909, FABP4, CCL5, CCL5, TLR4, TLR4, 
               
               
                   
                 regulation of defense 
                 PLA2G4A, TLR4, CLEC7A, CCL5, TLR4, IRF7, NOD2 
               
               
                   
                 response 
               
               
                   
                 GO: 0048584~positive 
                 C3AR1, LOC100131909, VEGFA, FABP4, CCL5, CCL5, 
               
               
                   
                 regulation of response to 
                 VEGFA, TLR4, TLR4, TNFSF13B, PLA2G4A, TNFSF13B, 
               
               
                   
                 stimulus 
                 IL27RA, TLR4, HIPK2, CLEC7A, VEGFA, CCL5, NOD2, 
               
               
                   
                   
                 TLR4, IRF7, VEGFA 
               
               
                   
                 GO: 0031960~response 
                 CCND1, A2M, FABP4, IL10, CCL5, CCL5, CDKN1A, CCL5, 
               
               
                   
                 to corticosteroid 
                 PTGS1, PLA2G4A, PTGS1, PTGS1 
               
               
                   
                 stimulus 
               
               
                   
                 GO: 0042221~response 
                 CD44, MMP2, CYP1B1, NRP2, CYP1B1, CDKN1A, NOD2, 
               
               
                   
                 to chemical stimulus 
                 EPAS1, HMOX1, AQP1, CYP1B1, ID2, SLC7A11, PLA2G4A, 
               
               
                   
                   
                 TLR4, THBD, CLEC7A, ENPP2, ATP1B1, ABCB1, PTGS1, 
               
               
                   
                   
                 PLIN2, PTGS1, THBD, VEGFA, CCL5, ID2, TLR4, EPS8, 
               
               
                   
                   
                 HSPB7, ME1, CX3CR1, CCR1, PTAFR, IL10, SLC7A11, 
               
               
                   
                   
                 VEGFA, MMP14, AQP1, CCL24, TLR4, VEGFA, CKLF, 
               
               
                   
                   
                 C3AR1, A2M, ME1, FABP4, CCL5, VEGFA, CYP1B1, TLR4, 
               
               
                   
                   
                 ID2, PTGS1, THBD, CCND1, OLR1, CCL5, ATP1B1 
               
               
                   
                 GO: 0065007~biological 
                 TCF4, NT5E, MFI2, NRP1, ADORA3, SLAMF7, RAB38, 
               
               
                   
                 regulation 
                 IL7R, PDK4, MAF, PHLDA1, MAML2, ARHGAP18, CD244, 
               
               
                   
                   
                 ID2, ANXA2P1, RAB7B, RIN2, ATF5, TFAP2A, MITF, BCL6, 
               
               
                   
                   
                 ABHD2, CSF1R, CKB, FGL2, TCF4, CD36, IGFBP3, PTGS1, 
               
               
                   
                   
                 FTHL3, HIVEP1, TNFRSF21, ABHD2, CCL5, ID2, PRDM1, 
               
               
                   
                   
                 FN1, TNFSF13B, TCF4, CX3CR1, CCR1, TRPS1, STATH, 
               
               
                   
                   
                 IL10, HMCN1, MAFB, TCF4, RASGRF1, A2M, FGD2, 
               
               
                   
                   
                 CYTIP, IFNGR1, SKIL, PHLDA1, LPXN, PTSS1, FGD2, 
               
               
                   
                   
                 NRCAM, ADAMDEC1, ICAM1, FGD4, MAML3, CYP1B1, 
               
               
                   
                   
                 DAPP1, CD36, ZFP36L1, ARHGAP18, PTRF, NOD2, EPAS1, 
               
               
                   
                   
                 ARHGAP18, HMOX1, LOC100131909, ANXA2P2, NRP1, 
               
               
                   
                   
                 CDK5RAP2, TNFRSF21, PLA2G4A, SERPINE2, TNFSF13B, 
               
               
                   
                   
                 IGFBP3, PTRF, FGD2, SUCNR1, THBO, P2RY14, CLEC7A, 
               
               
                   
                   
                 TRPS1, PTGS1, ARHGEF3, NGEF, ANXA2P1, IL7R, HSPB7, 
               
               
                   
                   
                 TRPS1, CD52, MITF, CD86, IL27RA, CKCR7, FGL2, VEGFA, 
               
               
                   
                   
                 RAPH1, VEGFA, MAML2, BCL6, MAML2, PDLIM7, 
               
               
                   
                   
                 ALCAM, FABP4, RAPH1, FGD4, GPR35, ID2, RGS13, 
               
               
                   
                   
                 ADAP2, DAB2, DAB2, ALCAM, ADAP2, FN1, CD44, CD36, 
               
               
                   
                   
                 CYP1B1, LBH, MTSS1, PHLDA1, AGPAT9, MMP9, DDIT4L, 
               
               
                   
                   
                 ATP10A, CDKN1A, IFNGR1, PDLIM7, ABHD2, EMR2, 
               
               
                   
                   
                 RGL1, TCF4, RAB7B, CXCR7, IFI30, APBB1IP, NGEF, CD9, 
               
               
                   
                   
                 PAPSS2, TRIM22, THBD, VEGFA, CSPG4, IFNGR1, 
               
               
                   
                   
                 MAML2, TLR4, SLC12A6, CDS2, C9ORF89, ABHD2, PSD3, 
               
               
                   
                   
                 CCL24, TLR4, IRF7, C3AR1, TRPM8, NRP1, VEGFA, 
               
               
                   
                   
                 ARID5B, TCF4, HIPK2, APBB1IP, VASH1, PSD3, TRPS1, 
               
               
                   
                   
                 DAB2, ADORA3, SNAI3, APBB1IP, NT5E, LPAR6, CYP1B1, 
               
               
                   
                   
                 DAB2, ATF5, MAML2, PTX3, ABHD2, TLR4, ENPP2, GLIS3, 
               
               
                   
                   
                 EMP1, BCL2A1, FN1, FN1, ANXA2P1, FGD2, RAB27B, 
               
               
                   
                   
                 EPS8, MAFB, PTAFR, CNIH3, IL2RG, PDK4, MMP14, 
               
               
                   
                   
                 ANKH, GPR183, ABHD2, ARHGAP20, CDX5RAP2, CCL5, 
               
               
                   
                   
                 NLRC4, CYP1B1, MTSS1, DOK2, TLR4, CRIP2, THBD, 
               
               
                   
                   
                 ADORA3, CCND1, CCL5, CD36, CHD9, TREM1, SERTAD1 
               
               
                   
                 GO: 0050865~regulation 
                 HMOX1, BCL6, LOC100131909, TLR4, TLR4, IL7R, 
               
               
                   
                 of cell activation 
                 TNFSF13B, TNFSF13B, BCL6, IL7R, CD86, IL27RA, TLR4, 
               
               
                   
                   
                 IL2RG, IL10, CDKN1A, TLR4 
               
               
                   
                 GO: 0048545~response 
                 HMOX1, AQP1, FABP4, A2M, CCL5, CCL5, PIA2G4A, 
               
               
                   
                 to steroid hormone 
                 PTGS1, CCND1, IL10, CCL5, MMP14, CDKN1A, AQP1, 
               
               
                   
                 stimulus 
                 PTGS1, PTGS1 
               
               
                   
                 GO: 0006935~chemotaxis 
                 C3AR1, IL10, CCL5, CCL5, CCL5, ENPP2, CCL24, NRP2, 
               
               
                   
                   
                 CKLF, CX3CR1, CCR1, PTAFR 
               
               
                   
                 GO: 0042330~taxis 
                 C3AR1, IL10, CCL5, CCL5, CCL5, ENPP2, CCL24, NRP2, 
               
               
                   
                   
                 CKLF, CX3CR1, CCR1, PTAFR 
               
               
                   
                 GO: 0002703~regulation 
                 IL7R, HMOX1, LOC100131909, BCL5, IL27RA, IL10, 
               
               
                   
                 of leukocyte mediated 
                 NOD2, IL7R, BCL6 
               
               
                   
                 immunity 
               
               
                   
                 GO: 0002822~regulation 
                 IL7R, BCL6, CD86, IL27RA, IL10, NOD2, IL7R, TNFSF13B, 
               
               
                   
                 of adaptive immune 
                 TNFSF13B, BCL6 
               
               
                   
                 response based on 
               
               
                   
                 somatic recombination 
               
               
                   
                 of immune receptors 
               
               
                   
                 built from 
               
               
                   
                 immunoglobulin 
               
               
                   
                 superfamily domains 
               
               
                   
                 G0: 0001568~blood 
                 CD44, HMOX1, MMP2, CSPG4, NRP1, ANXA2P1, VEGFA, 
               
               
                   
                 vessel development 
                 MMP19, ANXA2P2, NRP1, NRP1, ANXA2P1, VEGFA, 
               
               
                   
                   
                 ANXA2P1, NRP2, ZFP36L1, MMP14, VEGFA, VEGFA, 
               
               
                   
                   
                 EPAS1 
               
               
                   
                 G0: 0030154~cell 
                 PAQR5, FN1, CD44, NRP1, NRP2, IL7R, DAB2, ZFP36L1, 
               
               
                   
                 differentiation 
                 PAQR5, MMP9, MAF, GLDN, TUBB2A, EPAS1, PDLIM7, 
               
               
                   
                   
                 DAB2, ATF5, NRP1, ID2, TM7SF4, CDK5RAP2, ATF5, 
               
               
                   
                   
                 MITF, SERPINE2, BCL6, IGFBP3, MCOLN3, NGEF, IGFBP3, 
               
               
                   
                   
                 EMP1, FN1, FN1, VEGFA, CSPG4, MMP19, NGEF, ID2, 
               
               
                   
                   
                 FN1, PRDM1, IL7R, MITF, IL10, VEGFA, MMP14, GPR183, 
               
               
                   
                   
                 VEGFA, INA, RASGRF1, BCL6, MDGA1, ALCAM, PDLIM7, 
               
               
                   
                   
                 FABP4, CDK5RAP2, NRP1, VEGFA, ID2, NRCAM, CCND1, 
               
               
                   
                   
                 DAB2, MCOLN3, DAB2, ALCAM 
               
               
                   
                 GO: 0001944~vasculature 
                 CD44, HMOX1, MMP2, CSPG4, NRP1, ANXA2P1, VEGFA, 
               
               
                   
                 development 
                 MMP19, ANXA2P2, NRP1, NRP1, ANXA2P1, VEGFA, 
               
               
                   
                   
                 ANXA2P1, NRP2, ZFP36L1, MMP14, VEGFA, VEGFA, 
               
               
                   
                   
                 EPAS1 
               
               
                   
                 G0: 0002819~regulation 
                 IL7R, BCL6, CD86, IL27RA, IL10, NOD2, IL7R, TNFSF13B, 
               
               
                   
                 of adaptive immune 
                 TNFSF13B, BCL6 
               
               
                   
                 response 
               
               
                   
                 GO: 0051241~negative 
                 HMOX1, BCL6, LOC100131909, ANXA2P1, VEGFA, 
               
               
                   
                 regulation of 
                 ANXA2P2, ANXA2P1, VEGFA, ANXA2P1, BCLS, STATH, 
               
               
                   
                 multicellular organismal 
                 IL10, VEGFA, N0D2, VEGFA 
               
               
                   
                 GO: 0051704~multi- 
                 THBD, IFNGR1, CCL5, TLR4, CX3CR1, PTAFR, CD86, 
               
               
                   
                 organism process 
                 IL27RA, IL2RG, CXCR7, IL10, IRF7, NOD2, TLR4, MMP1, 
               
               
                   
                   
                 IFNGR1, GNLY, IFI44, CCL5, NLRC4, IFNGR1, TLR4, 
               
               
                   
                   
                 LILRB1, PLA2G4A, PTX3, THBD, CXCR7, TLR4, THBD, 
               
               
                   
                   
                 HIPK2, GNLY, CLE7A, CCL5, ICAM1, TRIM22 
               
               
                   
                 GO: 0007165~signal 
                 NRP1, CD36, FGD4, ADORA3, MTSS1, RAB38, DAPP1, 
               
               
                   
                 transduction 
                 IL7R, CD36, PDK4, ADORA3, ARHGAP18, NOD2, EPAS1, 
               
               
                   
                   
                 APB81IP, IFNGR1, ARHGAP18, LPAR6, HMOX1, 
               
               
                   
                   
                 LOC100131909, EMR2, ARHGAP18, RGL1, CD244, NRP1, 
               
               
                   
                   
                 RAB7B, RIN2, THFRSF21, RAB7B, TNFSF138, CSF1R, 
               
               
                   
                   
                 CXCR7, SUCNR1, TLR4, FGL2, P2RY14, CD36, CLEC7A, 
               
               
                   
                   
                 APBB1IP, TNFRSF21, CSPG4, ARHGEF3, IFNGR1, CCL5, 
               
               
                   
                   
                 RAB27B, TLR4, EPS8, IL7R, TNFSF138, CX3CR1, CCR1, 
               
               
                   
                   
                 PTAFR, CNIH3, IL2RG, CXCR7, PDK4, IL10, FGL2, RAPH1, 
               
               
                   
                   
                 CCL24, GPR183, TLR4, C3AR1, ARHGAP20, RASGRF1, 
               
               
                   
                   
                 ALCAM, NRP1, CCL5, RAPH1, FGD4, DOK2, MTSS1, 
               
               
                   
                   
                 GPR35, IFHGR1, TLR4, LPXN, ADORA3, CCND1, HIPK2, 
               
               
                   
                   
                 APBB1IP, CCL5, CD36, TREM1, ALCAM 
               
               
                   
                 GO: 0009617~response 
                 THBD, CCL5, CCL5, NLRC4, TLR4, TLR4, PLA2G4A, THBD, 
               
               
                   
                 to bacterium 
                 PTAFR, IL27RA, TLR4, THBD, IL10, GNLY, CCL5, NOD2, 
               
               
                   
                   
                 TLR4, GNLY 
               
               
                   
                 GO: 0048519~negative 
                 TCF4, NT5E, NRP1, TRPS1, IL7R, DAB2, DDIT4L, CDKN1A, 
               
               
                   
                 regulation of biological 
                 NOD2, NT5E, ABHD2, HMOX1, LOC100131909, DAB2, 
               
               
                   
                 process 
                 ATF5, ANXA2P2, ID2, NRP1, TCF4, ANXA2P1, ATF5, 
               
               
                   
                   
                 MITF, TNFSF13B, BCL6, ABHD2, ABHD2, IGFBP3, TLR4, 
               
               
                   
                   
                 IFI30, TCF4, TRPS1, GLIS3, CD9, PTGS1, IGFBP3, BCL2A1, 
               
               
                   
                   
                 FTGS1, FTHL3, HIVEP1, VEGFA, ANXA2P1, ABHD2, CCL5, 
               
               
                   
                   
                 TLR4, ANXA2P1, ID2, PRDM1, IL7R, TNFSF13B, TCF4, 
               
               
                   
                   
                 C9ORF89, TRF51, MAFB, ABHD2, MITF, IL27RA, TRPS1, 
               
               
                   
                   
                 STATH, IL10, VEGFA, MMP14, MAFB, IRF7, TLR4, 
               
               
                   
                   
                 ABHD2, VEGFA, TCF4, BCLG, FABP4, A2M, CCL5, NRP1, 
               
               
                   
                   
                 VEGFA, TLR4, SKIL, ID2, PTGS1, ARID5B, CCND1, RGS13, 
               
               
                   
                   
                 DAB2, TCF4, ADAMDEC1, HIPK2, CCL5, VASH1, DAB2, 
               
               
                   
                   
                 SERTAD1 
               
               
                   
                 GO: 0050864~regulation 
                 BCL6, IL27RA, IL2RG, IL10, CDKN1A, TNFSF13B, 
               
               
                   
                 of B cell activation 
                 TNFSF13B, BCL6 
               
               
                   
                 GO: 0001525~angiogenesis 
                 HMOX1, CSPG4, ANXA2P1, VEGFA, NRP1, MMP19, 
               
               
                   
                   
                 ANXA2P2, NRP1, ANXA2P1, VEGFA, NRP1, ANXA2P1, 
               
               
                   
                   
                 NRP2, MMP14, VEGFA, VEGFA, EPAS1 
               
               
                   
                 GO: 0048869~cellular 
                 PAQR5, FN1, CD44, NRP1, NRP2, IL7R, DAB2, ZFP36L1, 
               
               
                   
                 developments process 
                 PAQR5, MMP9, MAF, GLDN, TUBB2A, EPAS1, PDLIM7, 
               
               
                   
                   
                 DAB2, ATF5, NRP1, ID2, TM7SF4, CDK5RAP2, ATF5, 
               
               
                   
                   
                 MITF, SERPINE2, BCL6, IGFBP3, MCOLN3, CD9, NGEF, 
               
               
                   
                   
                 IGFBP3, EMP1, FN1, FN1, VEGFA, CSPG4, MMP19, NGEF, 
               
               
                   
                   
                 ID2, FN1, PRDM1, IL7R, MITF, IL10, VEGFA, MMP14, 
               
               
                   
                   
                 GPR183, VEGFA, INA, RASGRF1, BCL6, MDGA1, ALCAM, 
               
               
                   
                   
                 PDLIM7, FABP4, CDKSRAP2, NRP1, VEGFA, ID2, NRCAM, 
               
               
                   
                   
                 CCND1, DAB2, MCOLN3, DAB2, ALCAM 
               
               
                   
                 GO: 0002694~regulation 
                 BCL6, LOC100131909, HMOX1, IL7R, TNFSF13B, BCL6, 
               
               
                   
                 of leukocyte activation 
                 TNFSF13B, IL7R, CD86, IL27RA, IL2RG, IL10, CDKN1A 
               
               
                   
                 GO: 0044243~multicellular 
                 MMP2, MMP19, MMP9, MMP1 
               
               
                   
                 organismal catabolic 
               
               
                   
                 process 
               
               
                   
                 GO: 0030574~collagen 
                 MMP2, MMP19, MMP9, MMP1 
               
               
                   
                 cataboltc process 
               
               
                   
                 GO: 0016477~cell 
                 FN1, FN1, CD44, MDGA1, NRP1, NRP1, CCL5, CCL5, 
               
               
                   
                 migration 
                 NRP1, FN1, NRP2, S100A2, NRCAM, ABID5B, IL10, 
               
               
                   
                   
                 MMP14, CCL5, CKLF, ICAM1, FN1 
               
               
                   
                 GO: 0045595~regulation 
                 NRP1, CD36, CCL5, ID2, TLR4, IL7R, MAFB, IL7R, MITF, 
               
               
                   
                 of cell differentiation 
                 CD36, CD86, IL2RG, MAF, MAFB, TLR4, PDLIM7, BCL6, 
               
               
                   
                   
                 PDLIM7, ATF5, CDK5RAP2, NRP1, CCL5, NRP1, ID2, TLR4, 
               
               
                   
                   
                 CDK5RAP2, ATF5, MITF, BCL6, ID2, IGFBP3, NRCAM, 
               
               
                   
                   
                 CCND1, TLR4, CD36, CCL5, CD36, IGFBP3 
               
               
                   
                 GO: 0032879~regulation 
                 NRP1, VEGFA, CD36, ABHD2, RAB27B, ABHD2, CD36, 
               
               
                   
                 of localization 
                 IL10, MMP9, VEGFA, ABHD2, NOD2, VEGFA, ABHD2, 
               
               
                   
                   
                 HMOX1, BCL6, LOC100131909, NRP1, NRP1, VEGFA, 
               
               
                   
                   
                 SERPINE2, PLA2G4A, ABHD2, BCL6, PTX3, IGFBP3, 
               
               
                   
                   
                 ABHD2, PTGS1, CD36, CLEC7A, ENPP2, VASH1, CD36, 
               
               
                   
                   
                 IGFBP3, PTGS1, ICAM1, PTGS1 
               
               
                   
                 GO: 0050729~positive 
                 LOC100131909, TLR4, FABP4, CCL5, CCL5, TLR4, CCL5, 
               
               
                   
                 regulation of 
                 TLR4, TLR4, PLA2G4A 
               
               
                   
                 inflammatory response 
               
               
                   
                 GO: 0007186~G-protein 
                 LPAR6, C3AR1, LOC100131909, EMR2, ADORA3, CCL5, 
               
               
                   
                 coupled receptor protein 
                 CCL5, GPR35, CX3CR1, CCR1, ADORA3, PTAFR, CXCR7, 
               
               
                   
                 signaling pathway 
                 RGS13, CXCR7, SUCNR1, ADORA3, P2RY14, CCL5, 
               
               
                   
                   
                 ENPP2, GPR183 
               
               
                   
                 GO: 0051270~regulation 
                 ABHD2, HMOX1, BCL6, MRP1, VEGFA, ABHD2, MRP1, 
               
               
                   
                 of cell motion 
                 NRP1, VEGFA, SERPINE2, BCL6, ABHD2, IGFBP3, ABHD2, 
               
               
                   
                   
                 ABHD2, MMP9, VEGFA, ENPP2, VASH1, ABHD2, VEGFA, 
               
               
                   
                   
                 IGFBP3, ICAM1 
               
               
                   
                 GO: 0048518~positive 
                 TCF4, CD44, NRP1, CD36, FGD4, SLAMF7, MAML3, IL7R, 
               
               
                   
                 regulation of biological 
                 CD36, PHLDA1, PHLDA1, MAF, MMP9, CDKN1A, NOD2, 
               
               
                   
                 process 
                 MAML2, EPAS1, PDUM7, LOC100131909, HMOX1, ID2, 
               
               
                   
                   
                 NRP1, TCF4, MAML2, PLA2G4A, MITF, BCL6, PTX3, 
               
               
                   
                   
                 TNFSF138, IGFBP3, FGD2, TLR4, TCF4, CD36, CLEC7A, 
               
               
                   
                   
                 HGEF, GUS3, PTGS1, IGFBP3, PTGS1, VEGFA, ARHGEF3, 
               
               
                   
                   
                 FGD2, NGEF, CCL5, ID2, MAML2, TLR4, PRDM1, IL7R, 
               
               
                   
                   
                 TNFSF13B, TCF4, MAFB, MITF, CD86, IL27RA, IL2RG, 
               
               
                   
                   
                 IL10, MAFB, VEGFA, TLR4, IRF7, VEGFA, MAML2, TCF4, 
               
               
                   
                   
                 C3AR1, RASGRF1, BCL6, PDUM7, MAML2, FABP4, NRP1, 
               
               
                   
                   
                 CCL5, NLRC4, FGD4, VEGFA, FGD2, TLR4, CRIP2, 
               
               
                   
                   
                 PHLDA1, ID2, PTGS1, FGD2, NRCAM, CCND1, TCF4, 
               
               
                   
                   
                 HIPK2, CCL5, CD36, ICAM1, SERTAD1 
               
               
                   
                 GO: 001816~cytokine 
                 TLB4, FABP4, NLRC4, MAF, TLR4, NOD2, TLR4, TLR4, 
               
               
                   
                 production 
                 PTAFR 
               
               
                   
                 GO: 0007610~behavior 
                 C3AR1, RASGRF1, CCL5, CCL5, EPS8, NRP2, CX3CR1, 
               
               
                   
                   
                 CCR1, PTAFR, MCOLN3, HIPK2, IL10, MCOLN3, ANKH, 
               
               
                   
                   
                 CCL5, ENPP2, CCL24, CKLF 
               
               
                   
                 GO: 00550878~regulation 
                 THBD, ANXA2P1, CD36, ANXA2P2, ANXA2P1, ANXA2P1, 
               
               
                   
                 of body fluid levels 
                 THBD, CD36, STATH, THBD, CD36, HMCN1, CD36, CD9, 
               
               
                   
                   
                 PAPSS2 
               
               
                   
                 GO: 0032496~response 
                 THBO, CCL5, CCL5, TLR4, TLR4, PLA2G4A, THBD, PTAFR, 
               
               
                   
                 to lipopolysaccharide 
                 TLR4, THBD, IL10, CCL5, TLR4, NOD2 
               
               
                   
                 GO: 0002683~negative 
                 IL7R, HMOX1, BCL6, IL27RA, A2M, IL10, NOD2, IL7R, 
               
               
                   
                 regulation of immune 
                 BCL6 
               
               
                   
                 GO: 0051674~localization 
                 FN1, FN1, CD44, MDGA1, NRP1, NRP1, CCL5, CCL5, 
               
               
                   
                 of cell 
                 NRP1, FN1, NRP2, S100A2, NRCAM, ARID5B, IL10, 
               
               
                   
                   
                 MMP14, CCL5, CKLF, ICAM1, FN1 
               
               
                   
                 GO: 0048870~cell motility 
                 FN1, FN1, CD44, MDGA1, NRP1, NRP1, CCL5, CCL5, 
               
               
                   
                   
                 NRP1, FN1, NRP2, S100A2, NRCAM, ARID5B, IL10, 
               
               
                   
                   
                 MMP14, CCL5, CKLF, ICAM1, FN1 
               
               
                   
                 GO: 0046903~secretion 
                 HMOX1, LOC100131909, AQP1, ANKA2P1, DAB2, 
               
               
                   
                   
                 ANXA2P2, CCL5, CCL5, ANXA2P1, NLRC4, ANXA2P1, 
               
               
                   
                   
                 SYTL1, TNFSF138B, TNFSF13B, DAB2, STATH, DAS2, CCL5, 
               
               
                   
                   
                 AQP1, DAB2, CKLF 
               
               
                   
                 GO: 0006928~cell motion 
                 FN1, FN1, CD44, NRP1, CCL5, FN1, MTSS1, NRP2, 
               
               
                   
                   
                 S100A2, IL10, MMP14, CKLF, MDGA1, ALCAM, CCL5, 
               
               
                   
                   
                 NRP1, NRP1, MTSS1, ARID5B, NRCAM, CCL5, ENPP2, 
               
               
                   
                   
                 CD9, ALCAM, ICAM1, FN1 
               
               
                   
                 GO: 0048514~blood 
                 HMOX1, CSPG4, ANXA2P1, VEGFA, NRP1, MMP19, 
               
               
                   
                 vessel morphogenesis 
                 ANXA2P2, NRP1, NRP1, ANXA2P1, VEGFA, ANXA2P1, 
               
               
                   
                   
                 NRP2, ZFP36L1, MMP14, VEGFA, VEGFA, EPAS1 
               
               
                   
                 GO: 0001501~skeletal 
                 MMP2, ANXA2P1, PDLIM7, ANXA2P1, ANXA2P1, TRPS1, 
               
               
                   
                 system development 
                 TFAP2A, TRPS1, IGFBP3, ARID5B, STATH, TRPS1, MMP9, 
               
               
                   
                   
                 MMP14, ANKH, TRPS1, PAPSS2, IGFBP3, PDLIM7 
               
               
                   
                 GO: 0050867~positive 
                 BCL6, LOC100131909, TLR4, TLR4, IL7R, TNFSF13B, 
               
               
                   
                 regulation of cell 
                 TNFSF13B, BCL6, IL7R, CD86, TLR4, IL2RG, CDKN1A, 
               
               
                   
                 activation 
                 TLR4 
               
               
                   
                 GO: 0030247~polysaccharide 
                 CD44, FN1, FN1, VEGFA, VEGFA, FN1, SERPINE2, PTX3, 
               
               
                   
                 binding 
                 CLEC7A, VEGFA, NOD2, ENPP2, VEGFA, FN1 
               
               
                   
                 GO: 0001871~pattern 
                 CD44, FN1, FN1, VEGFA, VEGFA, FN1, SERPINE2, PTX3, 
               
               
                   
                 binding 
                 CLEC7A, VEGFA, NOD2, ENPP2, VEGFA, FN1 
               
               
                   
                 GO: 0004222~metalloendopeptidase 
                 MMP2, ADAMDEC1, MMP19, ADAMTS15, MMP9, 
               
               
                   
                 activity 
                 MMP14, MMP1 
               
               
                   
                 GO: 0002698~negative 
                 IL7R, HMOX1, BCL6, A2M, IL7R, BCL6 
               
               
                   
                 regulation of immune 
               
               
                   
                 effector process 
               
               
                   
                 GO: 0002698~positive 
                 LOC100131909, VEGFA, FABP4, CCL5, CCL5, TLR4, 
               
               
                   
                 regulation of response to 
                 VEGFA, TLR4, PLA2G4A, TLR4, CCL5, VEGFA, TLR4, 
               
               
                   
                 external stimulus 
                 VEGFA 
               
               
                   
                 GO: 0010033~response 
                 THBD, CD44, CYP1B1, CCL5, ID2, TLR4, EPS8, HSPB7, 
               
               
                   
                 to organic substance 
                 ME1, PTAFR, CYP1B1, IL10, MMP14, CDKN1A, AQP1, 
               
               
                   
                   
                 NOD2, TLR4, HMOX1, AQP1, CYP1B1, A2M, ME1, 
               
               
                   
                   
                 FABP4, CCL5, CYP1B1, ID2, TLR84, PLA2G4A, ID2, THBD, 
               
               
                   
                   
                 PTGS1, CCND1, THBD, TLR4, CLEC7A, CCL5, PTGS1, 
               
               
                   
                   
                 PLIN2, PTGS1 
               
               
                   
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
               
               
               
             
               
             
               
               
               
               
               
               
               
               
             
           
               
                 TABLE 6 
               
               
                   
               
               
                 Human monocyte study: pathways significantly enriched among genes upregulated by Probioglat relative to Copaxone ® at 6 hours. 
               
               
                   
               
             
             
               
                 Pathways significantly enriched among genes upregulated by Probioglat relative to GA (mannitol-corrected comparison) at 6 hours: 
               
             
          
           
               
                   
                   
                 Fold 
                   
                   
                   
               
               
                 Term 
                 Pvalue 
                 Enrichment 
                 Benjamini 
                 Probesets 
                 Genes 
               
               
                   
               
               
                 GO:0005576~extracellular 
                 1.59E−09 
                 4.042562158 
                 2.49E−07 
                 213503_X_AT, 210427_X_AT, 
                 ANXA2P1, ANXA2P1, CD40, PLAUR, CD40, GHRL, 
               
               
                 region 
                   
                   
                   
                 205153_S_AT, 214866_AT, 
                 IL7R, GLIPR1, CCL2, STATH, IL10, FGL2, MMP9, 
               
               
                   
                   
                   
                   
                 215346_AT, 223862_AT, 226218_AT, 
                 MMP1, ADAM9, COL6A1, CD14, ANXA2P2, 
               
               
                   
                   
                   
                   
                 226142_AT, 216598_S_AT, 
                 SRPX2, ANXA2P1, TNFSF13B, PTX3, EGF, 
               
               
                   
                   
                   
                   
                 206835_AT, 207433_AT, 227265_AT, 
                 ANTXR2, THBD, ADAMDEC1, ICAM1, CCL5, 
               
               
                   
                   
                   
                   
                 203936_S_AT, 204475_AT, 
                 TREM1, ICAM1 
               
               
                   
                   
                   
                   
                 202381_AT, 213428_S_AT, 201743_AT, 
                   
               
               
                   
                   
                   
                   
                 208816_X_AT, 205499_AT 
                   
               
               
                   
                   
                   
                   
                 201590_X_AT, 223502_S_AT, 206157_AT, 
                   
               
               
                   
                   
                   
                   
                 206254_AT, 228573_AT, 
                   
               
               
                   
                   
                   
                   
                 203887_S_AT, 206134_AT, 
                   
               
               
                   
                   
                   
                   
                 202637_S_AT, 1555759_A_AT, 
                   
               
               
                   
                   
                   
                   
                 215434_AT, 202638_S_AT 
                   
               
               
                 GO:0002376~immune 
                 1.04E−08 
                 4.156626506 
                 1.53E−05 
                 209933_S_AT, 210017_AT, 
                 CD300A, MALT1, CD40, CD40, NFKBIA, VPS33A, 
               
               
                 system process 
                   
                   
                   
                 205153_S_AT, 215346_AT, 
                 IL7R, CCL2, IL10, MMP9, SOD2, GPR183, NOD2, 
               
               
                   
                   
                   
                   
                 201502_S_AT, 204590_X_AT, 
                 CD55, KYNU, CD55, SOD2, ADAM9, CD14, 
               
               
                   
                   
                   
                   
                 226218_AT, 216598_S_AT, 
                 TNFSF13B, PTX3, SOD2, ICAM1, IFIH1, CCL5, 
               
               
                   
                   
                   
                   
                 207433_AT, 203936_S_AT, 221477_S_AT, 
                 MLF1, KYNU, TREM1, ICAM1 
               
               
                   
                   
                   
                   
                 205419_AT, 220066_AT, 
                   
               
               
                   
                   
                   
                   
                 201926_S_AT, 217388_S_AT, 
                   
               
               
                   
                   
                   
                   
                 1555950_A_AT, 215223_S_AT, 
                   
               
               
                   
                   
                   
                   
                 202381_AT, 201743_AT, 223502_S_AT, 
                   
               
               
                   
                   
                   
                   
                 206157_AT, 216841_S_AT, 
                   
               
               
                   
                   
                   
                   
                 202637_S_AT, 219209_AT, 
                   
               
               
                   
                   
                   
                   
                 1555759_A_AT, 204784_S_AT, 
                   
               
               
                   
                   
                   
                   
                 210663_S_AT, 219434_AT, 202638_S_AT 
                   
               
               
                 GO:0048583~regulation of 
                 1.56E−07 
                 5.897095846 
                 0.000115129 
                 213503_X_AT, 210017_AT, 
                 ANXA2P1, MALT1, FABP4, ANXA2P2, ANXA2P1, 
               
               
                 response to stimulus 
                   
                   
                   
                 203980_AT, 208816_X_AT, 
                 CD40, NFKBIA, ANXA2P1, CD40, GHRL, IL7R, 
               
               
                   
                   
                   
                   
                 210427_X_AT, 205153_S_AT, 
                 THFSF13B, IL10, ICAM1, CCL5, NOD2, CD55, 
               
               
                   
                   
                   
                   
                 201502_S_AT, 201590_X_AT, 
                 NT5E, CD55, ICAM1 
               
               
                   
                   
                   
                   
                 215346_AT, 223862_AT, 226218_AT, 
                   
               
               
                   
                   
                   
                   
                 223502_S_AT, 207433_AT, 
                   
               
               
                   
                   
                   
                   
                 202637_S_AT, 1555759_A_AT, 
                   
               
               
                   
                   
                   
                   
                 220066_AT, 201926_S_AT, 
                   
               
               
                   
                   
                   
                   
                 203939_AT, 1555950_A_AT, 202638_S_AT 
                   
               
               
                 GO:0044421~extracellular 
                 2.87E−06 
                 4.664494797 
                 0.000225327 
                 213428_S_AT, 202381_AT, 
                 COL6A1, ADAM9, ANXA2P1, ANXA2P2, 
               
               
                 region part 
                   
                   
                   
                 213503_X_AT, 208816_X_AT, 
                 ANXA2P1, ANXA2P1, GHRL, CCL2, TNFSF13B, 
               
               
                   
                   
                   
                   
                 210427_X_AT, 201590_X_AT, 
                 EGF, THBD, IL10, ICAM1, FGL2, MMP9, CCL5, 
               
               
                   
                   
                   
                   
                 223862_AT, 216598_S_AT, 
                 MMP1, ICAM1 
               
               
                   
                   
                   
                   
                 223502_S_AT, 206254_AT, 
                   
               
               
                   
                   
                   
                   
                 203887_S_AT, 207433_AT, 
                   
               
               
                   
                   
                   
                   
                 202637_S_AT, 227265_AT, 
                   
               
               
                   
                   
                   
                   
                 203936_S_AT, 1555759_A_AT, 
                   
               
               
                   
                   
                   
                   
                 204475_AT, 202638_S_AT 
                   
               
               
                 GO:0048519~negative 
                 6.21E−07 
                 2.625285194 
                 0.000305261 
                 213891_S_AT, 203927_AT, 
                 TCF4, NFKBIE, ANXA2P1, MALT1, ANXA2P1, 
               
               
                 regulation of biological 
                   
                   
                   
                 213503_X_AT, 210017_AT, 
                 P2RX4, NFKBIA, PRDM1, GHRL, IL7R, TCF4, 
               
               
                 process 
                   
                   
                   
                 210427_X_AT, 204088_AT, 201502_S_AT, 
                 CCL2, MAFB, DAB2, STATH, IL10, NOD2, SOD2, 
               
               
                   
                   
                   
                   
                 228964_AT, 223862_AT, 
                 NT5E, ARL6IP5, BIRC3, SOD2, TNFRSF9, ARL6IP5, 
               
               
                   
                   
                   
                   
                 226218_AT, 212387_AT, 216598_S_AT, 
                 FABP4, ANXA2P2, ANXA2P1, CHST11, MITF, 
               
               
                   
                   
                   
                   
                 218559_S_AT, 201278_AT, 
                 THFSF13B, EGF, SOD2, TNFAIP3, ADAMDEC1, 
               
               
                   
                   
                   
                   
                 206835_AT, 207433_AT, 220066_AT, 
                 CCL5, CD9 
               
               
                   
                   
                   
                   
                 221477_S_AT, 203939_AT, 
                   
               
               
                   
                   
                   
                   
                 200761_S_AT, 210538_S_AT, 
                   
               
               
                   
                   
                   
                   
                 215223_S_AT, 207536_S_AT, 
                   
               
               
                   
                   
                   
                   
                 200760_S_AT, 203980_AT, 
                   
               
               
                   
                   
                   
                   
                 208816_X_AT, 201590_X_AT, 
                   
               
               
                   
                   
                   
                   
                 219634_AT, 226066_AT, 223502_S_AT, 
                   
               
               
                   
                   
                   
                   
                 206254_AT, 216841_S_AT, 
                   
               
               
                   
                   
                   
                   
                 202644_S_AT, 206134_AT, 
                   
               
               
                   
                   
                   
                   
                 1555759_A_AT, 201005_AT 
                   
               
               
                 GO:0006955~immune 
                 1.10E−06 
                 4.644030668 
                 0.000325195 
                 209933_S_AT, 210017_AT, 201743_AT, 
                 CD300A, MALT1, CD14, IL7R, CCL2, TNFSF13B, 
               
               
                 response 
                   
                   
                   
                 226218_AT, 216598_S_AT, 
                 PTX3, IFIH1, ICAMl, IL10, CCL5, NOD2, GPR183, 
               
               
                   
                   
                   
                   
                 223502_S_AT, 206157_AT, 219209_AT, 
                 KYNU, CD55, KYNU, TREM1, CD55, ICAM1 
               
               
                   
                   
                   
                   
                 202637_S_AT, 207433_AT, 
                   
               
               
                   
                   
                   
                   
                 1555759_A_AT, 220066_AT, 
                   
               
               
                   
                   
                   
                   
                 205419_AT, 210663_S_AT, 
                   
               
               
                   
                   
                   
                   
                 201926_S_AT, 217388_S_AT, 
                   
               
               
                   
                   
                   
                   
                 219434_AT, 1555950_A_AT, 202638_S_AT 
                   
               
               
                 GO:0002237~response to 
                 1.01E−06 
                 14.53261321 
                 0.000370434 
                 203887_S_AT, 210017_AT, 201743_AT, 
                 THBD, MALT1, CD14, IL10, NFKBIA, CCL5, NOD2, 
               
               
                 molecule of bacterial origin 
                   
                   
                   
                 207433_AT, 201502_S_AT, 
                 CCL2 
               
               
                   
                   
                   
                   
                 1555759_A_AT, 220066_AT, 216598_S_AT 
                   
               
               
                 GO:0005886~plasma 
                 7.17E−06 
                 2.132725656 
                 0.000375322 
                 219358_S_AT, 204912_AT, 
                 ADAP2, IL10RA, CD300A, ANXA2P1, CD36, 
               
               
                 membrane 
                   
                   
                   
                 209933_S_AT, 213503_X_AT, 
                 ANXA2P1, P2RX4, FXYD2, CD40, PLAUR, CD40, 
               
               
                   
                   
                   
                   
                 209555_S_AT, 210427_X_AT, 
                 VPS33A, IL7R, SNX20, SYNJ2, SYNJ2, GPR183, 
               
               
                   
                   
                   
                   
                 204088_AT, 207434_S_AT, 
                 NOD2, CD55, NT5E, CD55, STEAP1, LPAR6, 
               
               
                   
                   
                   
                   
                 205153_S_AT, 214866_AT, 215346_AT, 
                 ADAM9, COL6A1, TNFRSF9, CD14, ANXA2P2, 
               
               
                   
                   
                   
                   
                 204590_X_AT, 226218_AT, 
                 ANXA2P1, IFNGR1, TNFSF13B, SNX20, EGF, 
               
               
                   
                   
                   
                   
                 229045_AT, 216180_S_AT, 212828_AT, 
                 ANTXR2, THBD, ICAM1, PLEKHO1, GPR34, 
               
               
                   
                   
                   
                   
                 205419_AT, 220066_AT, 
                 ITGB5, CD9, TREM1, ICAM1 
               
               
                   
                   
                   
                   
                 201926_S_AT, 203939_AT, 
                   
               
               
                   
                   
                   
                   
                 1555950_A_AT, 205542_AT, 
                   
               
               
                   
                   
                   
                   
                 218589_AT, 202381_AT, 213428_S_AT, 
                   
               
               
                   
                   
                   
                   
                 207536_S_AT, 201743_AT, 
                   
               
               
                   
                   
                   
                   
                 208816_X_AT, 201590_X_AT, 
                   
               
               
                   
                   
                   
                   
                 211676_S_AT, 223502_S_AT, 
                   
               
               
                   
                   
                   
                   
                 228869_AT, 206254_AT, 228573_AT, 
                   
               
               
                   
                   
                   
                   
                 203887_S_AT, 202637_S_AT, 
                   
               
               
                   
                   
                   
                   
                 218223_S_AT, 244434_AT, 201125_S_AT, 
                   
               
               
                   
                   
                   
                   
                 201005_AT, 219434_AT, 202638_S_AT 
                   
               
               
                 GO:0051707~response to 
                 2.07E−06 
                 7.289156627 
                 0.000507682 
                 203887_S_AT, 210017_AT, 201743_AT, 
                 THBD, MALT1, CD14, IFIH1, IL10, NFKBIA, CCL5, 
               
               
                 other organism 
                   
                   
                   
                 219209_AT, 207433_AT, 
                 NOD2, IFNGR1, CCL2, PTX3 
               
               
                   
                   
                   
                   
                 201502_S_AT, 1555759_A_AT, 
                   
               
               
                   
                   
                   
                   
                 220066_AT, 211676_S_AT, 
                   
               
               
                   
                   
                   
                   
                 216598_S_AT, 206157_AT 
                   
               
               
                 GO:0050878~regulation of 
                 2.72E−06 
                 12.58047114 
                 0.000572071 
                 206835_AT, 213503_X_AT, 
                 STATH, ANXA2P1, CD36, THBD, ANXA2P2, 
               
               
                 body fluid levels 
                   
                   
                   
                 209555_S_AT, 203887_S_AT, 
                 ANXA2P1, CD40, PLAUR, ANXA2P1, CD40, CD9 
               
               
                   
                   
                   
                   
                 208816_X_AT, 210427_X_AT, 
                   
               
               
                   
                   
                   
                   
                 205153_S_AT, 214866_AT, 
                   
               
               
                   
                   
                   
                   
                 201590_X_AT, 215346_AT, 201005_AT 
                   
               
               
                 GO:0032879~regulation of 
                 3.74E−06 
                 4.52842902 
                 0.000688621 
                 202381_AT, 203927_AT, 209555_S_AT, 
                 ADAM9, NFKBIE, CD36, ARL6IP5, RAB27B, 
               
               
                 localization 
                   
                   
                   
                 200760_S_AT, 228708_AT, 
                 P2RX4, CD40, NFKBIA, CD40, GHRL, PTX3, EGF, 
               
               
                   
                   
                   
                   
                 204088_AT, 205153_S_AT, 201502_S_AT, 
                 IL10, ICAM1, MMP9, NOD2, ARL6IP5, ICAM1 
               
               
                   
                   
                   
                   
                 215346_AT, 223862_AT, 
                   
               
               
                   
                   
                   
                   
                 206157_AT, 206254_AT, 207433_AT, 
                   
               
               
                   
                   
                   
                   
                 202637_S_AT, 203936_S_AT, 
                   
               
               
                   
                   
                   
                   
                 220066_AT, 200761_S_AT, 202638_S_AT 
                   
               
               
                 GO:0032496~response to 
                 6.46E−06 
                 14.75060241 
                 0.000865084 
                 203887_S_AT, 201743_AT, 
                 THBD, CD14, IL10, NFKBIA, CCL5, NOD2, CCL2 
               
               
                 lipopolysaccharide 
                   
                   
                   
                 207433_AT, 201502_S_AT, 
                   
               
               
                   
                   
                   
                   
                 1555759_A_AT, 220066_AT, 216598_S_AT 
                   
               
               
                 GO:0060089~molecular 
                 5.73E−06 
                 2.807496252 
                 0.000876051 
                 204912_AT, 209933_S_AT, 209555_S_AT, 
                 IL10RA, CD300A, CD36, MALT1, P2RX4, CD40, 
               
               
                 transducer activity 
                   
                   
                   
                 210017_AT, 204088_AT, 
                 CD40, PLAUR, GHRL, IL7R, CCL2, GPR183, 
               
               
                   
                   
                   
                   
                 205153_S_AT, 215346_AT, 214866_AT, 
                 LPAR6, TNFRSF9, CD14, SRA1, IFNGR1, EGF, 
               
               
                   
                   
                   
                   
                 223862_AT, 226218_AT, 
                 ANTXR2, THBD, ICAM1, CCL5, ITGB5, GPR34, 
               
               
                   
                   
                   
                   
                 216598_S_AT, 205419_AT, 218589_AT, 
                 TREM1, ICAM1 
               
               
                   
                   
                   
                   
                 207536_S_AT, 201743_AT, 
                   
               
               
                   
                   
                   
                   
                 224130_S_AT, 211676_S_AT, 
                   
               
               
                   
                   
                   
                   
                 206254_AT, 228573_AT, 
                   
               
               
                   
                   
                   
                   
                 203887_S_AT, 202637_S_AT, 
                   
               
               
                   
                   
                   
                   
                 1555759_A_AT, 201125_S_AT, 
                   
               
               
                   
                   
                   
                   
                 244434_AT, 219434_AT, 202638_S_AT 
                   
               
               
                 GO:004871~signal 
                 5.73E−06 
                 2.807496252 
                 0.000876051 
                 204912_AT, 209933_S_AT, 209555_S_AT, 
                 IL10RA, CD300A, CD36, MALT1, P2RX4, CD40, 
               
               
                 transducer activity 
                   
                   
                   
                 210017_AT, 204088_AT, 
                 CD40, PLAUR, GHRL, IL7R, CCL2, GPR183, 
               
               
                   
                   
                   
                   
                 205153_S_AT, 215346_AT, 214866_AT, 
                 LPAR6, TNFRSF9, CD14, SRA1, IFNGR1, EGF, 
               
               
                   
                   
                   
                   
                 223862_AT, 226218_AT, 
                 ANTXR2, THBD, ICAM1, CCL5, ITGB5, GPR34, 
               
               
                   
                   
                   
                   
                 216598_S_AT, 205419_AT, 218589_AT, 
                 TREM1, ICAM1 
               
               
                   
                   
                   
                   
                 207536_S_AT, 201743_AT, 
                   
               
               
                   
                   
                   
                   
                 224130_S_AT, 211676_S_AT, 
                   
               
               
                   
                   
                   
                   
                 206254_AT, 228573_AT, 
                   
               
               
                   
                   
                   
                   
                 203887_S_AT, 202637_S_AT, 
                   
               
               
                   
                   
                   
                   
                 1555759_A_AT, 201125_S_AT, 
                   
               
               
                   
                   
                   
                   
                 244434_AT, 219434_AT, 202638_S_AT 
                   
               
               
                 GO:0065007~biological 
                 5.36E−06 
                 1.477358354 
                 0.000877763 
                 219358_S_AT, 213891_S_AT, 
                 ADAP2, TCF4, CD36, MALT1, P2RX4, NFE2L3, 
               
               
                 regulation 
                   
                   
                   
                 209555_S_AT, 210017_AT, 
                 NFKBIA, VPS33A, DAB2, AGPAT9, MMP9, SOD2, 
               
               
                   
                   
                   
                   
                 204088_AT, 236471_AT, 201502_S_AT, 
                 NOD2, NT5E, CD55, ARHGAP18, BIRC3, SOD2, 
               
               
                   
                   
                   
                   
                 204590_X_AT, 201278_AT, 
                 LPAR6, ADAM9, TNFRSF9, ARL6IP5, ARHGAP18, 
               
               
                   
                   
                   
                   
                 224480_S_AT, 203936_S_AT, 
                 ANXA2P2, BID, ANXA2P1, NFE2L3, CHST11, 
               
               
                   
                   
                   
                   
                 221477_S_AT, 220066_AT, 
                 MITF, PTX3, TNFSF13B, EGF, MXD1, SOD2, 
               
               
                   
                   
                   
                   
                 203939_AT, 1555950_A_AT, 
                 THBD, TNFAIP3, CD9, BID, GLRX3, NFKBIE, 
               
               
                   
                   
                   
                   
                 225166_AT, 210538_S_AT, 
                 ANXA2P1, RAB27B, CD40, ANXA2P1, PLAUR, 
               
               
                   
                   
                   
                   
                 215223_S_AT, 218589_AT, 
                 PRDM1, CD40, GHRL, IL7R, CCL2, TCF4, MAFB, 
               
               
                   
                   
                   
                   
                 202381_AT, 207536_S_AT, 
                 HNRPLL, BID, STATH, IL10, FGL2, GPR183, CD55, 
               
               
                   
                   
                   
                   
                 200760_S_AT, 225171_AT, 
                 ARL6IP5, FABP4, CD14, TNFAIP6, SRA1, MTSS1, 
               
               
                   
                   
                   
                   
                 208816_X_AT, 211725_S_AT, 
                 CYTIP, IFNGR1, CAST, LPXN, ADAMDEC1, IFIH1, 
               
               
                   
                   
                   
                   
                 201590_X_AT, 204702_S_AT, 219634_AT, 
                 ICAM1, CCL5, GPR34, TREM1, ICAM1 
               
               
                   
                   
                   
                   
                 226066_AT, 206157_AT, 
                   
               
               
                   
                   
                   
                   
                 223502_S_AT, 206254_AT, 
                   
               
               
                   
                   
                   
                   
                 226275_AT, 216841_S_AT, 
                   
               
               
                   
                   
                   
                   
                 203887_S_AT, 202644_S_AT, 
                   
               
               
                   
                   
                   
                   
                 201005_AT, 204493_AT, 
                   
               
               
                   
                   
                   
                   
                 209080_X_AT, 203927_AT, 
                   
               
               
                   
                   
                   
                   
                 213503_X_AT, 228708_AT, 
                   
               
               
                   
                   
                   
                   
                 205153_S_AT, 210427_X_AT, 214866_AT, 
                   
               
               
                   
                   
                   
                   
                 228964_AT, 215346_AT, 
                   
               
               
                   
                   
                   
                   
                 223862_AT, 226218_AT, 216598_S_AT, 
                   
               
               
                   
                   
                   
                   
                 212387_AT, 218559_S_AT, 
                   
               
               
                   
                   
                   
                   
                 225386_S_AT, 227143_S_AT, 206835_AT, 
                   
               
               
                   
                   
                   
                   
                 207433_AT, 227265_AT, 
                   
               
               
                   
                   
                   
                   
                 205419_AT, 201926_S_AT, 200761_S_AT, 
                   
               
               
                   
                   
                   
                   
                 203980_AT, 201743_AT, 
                   
               
               
                   
                   
                   
                   
                 206026_S_AT, 224130_S_AT, 
                   
               
               
                   
                   
                   
                   
                 203037_S_AT, 209606_AT, 
                   
               
               
                   
                   
                   
                   
                 211676_S_AT, 208908_S_AT, 
                   
               
               
                   
                   
                   
                   
                 216250_S_AT, 206134_AT, 
                   
               
               
                   
                   
                   
                   
                 219209_AT, 202637_S_AT, 
                   
               
               
                   
                   
                   
                   
                 1555759_A_AT, 244434_AT, 
                   
               
               
                   
                   
                   
                   
                 219434_AT, 202638_S_AT 
                   
               
               
                 GO:0065008~regulation of 
                 6.39E−06 
                 2.871224233 
                 0.000941783 
                 203927_AT, 213503_X_AT, 
                 NFKBIE, ANXA2P1, CD36, P2RX4, ANXA2P1, 
               
               
                 biological quality 
                   
                   
                   
                 209555_S_AT, 204088_AT, 
                 CD40, NFKBIA, CD40, PLAUR, GHRL, IL7R, CCL2, 
               
               
                   
                   
                   
                   
                 210427_X_AT, 205153_S_AT, 
                 BID, DAB2, STATH, IL10, SOD2, CD55, CD55, 
               
               
                   
                   
                   
                   
                 201502_S_AT, 215346_AT, 
                 SOD2, FABP4, ANXA2P2, BID, ANXA2P1, 
               
               
                   
                   
                   
                   
                 214866_AT, 223862_AT, 226218_AT, 
                 TNFSF13B, SOD2, THBD, CCL5, CD9, BID, GLRX3 
               
               
                   
                   
                   
                   
                 216598_S_AT, 227143_S_AT, 
                   
               
               
                   
                   
                   
                   
                 201278_AT, 206835_AT, 207433_AT, 
                   
               
               
                   
                   
                   
                   
                 221477_S_AT, 201926_S_AT, 
                   
               
               
                   
                   
                   
                   
                 1555950_A_AT, 215223_S_AT, 
                   
               
               
                   
                   
                   
                   
                 203980_AT, 208816_X_AT, 
                   
               
               
                   
                   
                   
                   
                 211725_S_AT, 201590_X_AT, 
                   
               
               
                   
                   
                   
                   
                 223502_S_AT, 216841_S_AT, 
                   
               
               
                   
                   
                   
                   
                 203887_S_AT, 1555759_A_AT, 
                   
               
               
                   
                   
                   
                   
                 201005_AT, 204493_AT, 209080_X_AT 
                   
               
               
                 GO:0050789~regulation of 
                 7.87E−06 
                 1.49362031 
                 0.000966198 
                 219358_S_AT, 213891_S_AT, 
                 ADAP2, TCF4, CD36, MALT1, P2RX4, NFE2L3, 
               
               
                 biological process 
                   
                   
                   
                 209555_S_AT, 210017_AT, 
                 NFKBIA, VPS33A, DAB2, AGPAT9, MMP9, SOD2, 
               
               
                   
                   
                   
                   
                 204088_AT, 236471_AT, 201502_S_AT, 
                 NOD2, NT5E, CD55, ARHGAP18, BIRC3, SOD2, 
               
               
                   
                   
                   
                   
                 204590_X_AT, 201278_AT, 
                 LPAR6, ADAM9, TNFRSF9, ARL6IP5, ARHGAP18, 
               
               
                   
                   
                   
                   
                 224480_S_AT, 203936_S_AT, 
                 ANXA2P2, BID, ANXA2P1, NFE2L3, CHST11, 
               
               
                   
                   
                   
                   
                 221477_S_AT, 220066_AT, 
                 MITF, PTX3, TNFSF13B, EGF, MXD1, SOD2, 
               
               
                   
                   
                   
                   
                 203939_AT, 1555950_A_AT, 
                 TNFAIP3, CD9, BID, GLRX3, NFKBIE, ANXA2P1, 
               
               
                   
                   
                   
                   
                 225166_AT, 210538_S_AT, 
                 RAB27B, CD40, ANXA2P1, PLAUR, PRDM1, 
               
               
                   
                   
                   
                   
                 215223_S_AT, 218589_AT, 
                 CD40, GHRL, IL7R, CCL2, TCF4, MAFB, HNRPLL, 
               
               
                   
                   
                   
                   
                 202381_AT, 207536_S_AT, 
                 BID, STATH, IL10, FGL2, GPR183, CD55, ARL6IP5, 
               
               
                   
                   
                   
                   
                 200760_S_AT, 225171_AT, 
                 FABP4, CD14, TNFAIP6, SRA1, MTSS1, CYTIP, 
               
               
                   
                   
                   
                   
                 208816_X_AT, 211725_S_AT, 
                 IFNGR1, LPXN, ADAMDEC1, IFIH1, ICAM1, CCL5, 
               
               
                   
                   
                   
                   
                 201590_X_AT, 204702_S_AT, 219634_AT, 
                 GPR34, TREM1, ICAM1 
               
               
                   
                   
                   
                   
                 226066_AT, 206157_AT, 
                   
               
               
                   
                   
                   
                   
                 223502_S_AT, 206254_AT, 
                   
               
               
                   
                   
                   
                   
                 226275_AT, 216841_S_AT, 
                   
               
               
                   
                   
                   
                   
                 202644_S_AT, 201005_AT, 204493_AT, 
                   
               
               
                   
                   
                   
                   
                 209080_X_AT, 203927_AT, 
                   
               
               
                   
                   
                   
                   
                 213503_X_AT, 228708_AT, 
                   
               
               
                   
                   
                   
                   
                 205153_S_AT, 210427_X_AT, 
                   
               
               
                   
                   
                   
                   
                 214866_AT, 228964_AT, 215346_AT, 
                   
               
               
                   
                   
                   
                   
                 223862_AT, 226218_AT, 
                   
               
               
                   
                   
                   
                   
                 216598_S_AT, 212387_AT, 
                   
               
               
                   
                   
                   
                   
                 218559_S_AT, 225386_S_AT, 
                   
               
               
                   
                   
                   
                   
                 227143_S_AT, 206835_AT, 207433_AT, 
                   
               
               
                   
                   
                   
                   
                 227265_AT, 205419_AT, 
                   
               
               
                   
                   
                   
                   
                 201926_S_AT, 200761_S_AT, 
                   
               
               
                   
                   
                   
                   
                 203980_AT, 201743_AT, 
                   
               
               
                   
                   
                   
                   
                 206026_S_AT, 224130_S_AT, 
                   
               
               
                   
                   
                   
                   
                 203037_S_AT, 209606_AT, 
                   
               
               
                   
                   
                   
                   
                 211676_S_AT, 216250_S_AT, 
                   
               
               
                   
                   
                   
                   
                 206134_AT, 219209_AT, 
                   
               
               
                   
                   
                   
                   
                 202637_S_AT, 1555759_A_AT, 
                   
               
               
                   
                   
                   
                   
                 244434_AT, 219434_AT, 202638_S_AT 
                   
               
               
                 GO:0051049~regulation of 
                 8.87E−06 
                 5.49711891 
                 0.00100533 
                 203927_AT, 202381_AT, 200760_S_AT, 
                 NFKBIE, ADAM9, ARL6IP5, RAB27B, CD40, 
               
               
                 transport 
                   
                   
                   
                 228708_AT, 205153_S_AT, 
                 P2RX4, CD40, NFKBIA, GHRL, PTX3, EGF, IL10, 
               
               
                   
                   
                   
                   
                 204088_AT, 215346_AT, 201502_S_AT, 
                 NOD2, ARL6IP5 
               
               
                   
                   
                   
                   
                 223862_AT, 206157_AT, 
                   
               
               
                   
                   
                   
                   
                 206254_AT, 207433_AT, 
                   
               
               
                   
                   
                   
                   
                 220066_AT, 200761_S_AT 
                   
               
               
                 GO:0004872~receptor 
                 4.04E−06 
                 3.357899833 
                 0.001236866 
                 218589_AT, 204912_AT, 
                 LPAR6, IL10RA, CD300A, TNFRSF9, CD36, CD14, 
               
               
                 activity 
                   
                   
                   
                 209933_S_AT, 207536_S_AT, 
                 P2RX4, CD40, PLAUR, SRA1, CD40, GHRL, 
               
               
                   
                   
                   
                   
                 209555_S_AT, 201743_AT, 204088_AT, 
                 IFNGR1, IL7R, ANTXR2, THBD, ICAM1, GPR183, 
               
               
                   
                   
                   
                   
                 205153_S_AT, 214866_AT, 
                 GPR34, ITGB5, TREM1, ICAM1 
               
               
                   
                   
                   
                   
                 224130_S_AT, 215346_AT, 223862_AT, 
                   
               
               
                   
                   
                   
                   
                 211676_S_AT, 226218_AT, 
                   
               
               
                   
                   
                   
                   
                 228573_AT, 203887_S_AT, 202637_S_AT, 
                   
               
               
                   
                   
                   
                   
                 205419_AT, 244434_AT, 
                   
               
               
                   
                   
                   
                   
                 201125_S_AT, 219434_AT, 202638_S_AT 
                   
               
               
                 GO:0009611~response to 
                 1.27E−05 
                 4.789156627 
                 0.001249473 
                 215223_S_AT, 209555_S_AT, 
                 SOD2, CD36, CD14, CD40, CD40, TNFAIP6, 
               
               
                 wounding 
                   
                   
                   
                 201743_AT, 205153_S_AT, 
                 PLAUR, CCL2, PTX3, SOD2, THBD, 1L10, CCL5, 
               
               
                   
                   
                   
                   
                 215346_AT, 206026_S_AT, 214866_AT, 
                 SOD2, CD9, CD55, CD55 
               
               
                   
                   
                   
                   
                 216598_S_AT, 206157_AT, 
                   
               
               
                   
                   
                   
                   
                 216841_S_AT, 203887_S_AT, 
                   
               
               
                   
                   
                   
                   
                 207433_AT, 1555759_A_AT, 
                   
               
               
                   
                   
                   
                   
                 221477_S_AT, 201005_AT, 
                   
               
               
                   
                   
                   
                   
                 201926_S_AT, 1555950_A_AT 
                   
               
               
                 hsa04060: Cytokine- 
                 1.73E−05 
                 6.212389381 
                 0.001276815 
                 204912_AT, 207536_S_AT, 207433_AT, 
                 IL10RA, TNFRSF9, IL10, CD40, CD40, CCL5, 
               
               
                 cytokine receptor 
                   
                   
                   
                 205153_S_AT, 215346_AT, 
                 IFNGR1, IL7R, CCL2, TNFSF13B, EGF 
               
               
                 interaction 
                   
                   
                   
                 1555759_A_AT, 211676_S_AT, 
                   
               
               
                   
                   
                   
                   
                 226218_AT, 216598_S_AT, 
                   
               
               
                   
                   
                   
                   
                 223502_S_AT, 206254_AT 
                   
               
               
                 GO:0002682~regulation of 
                 1.23E−05 
                 5.312341804 
                 0.001290482 
                 210017_AT, 205153_S_AT, 215346_AT, 
                 MALT1, CD40, CD40, NFKBIA, IL7R, MITF, 
               
               
                 immune system process 
                   
                   
                   
                 201502_S_AT, 226218_AT, 
                 TNFSF13B, MAFB, IL10, ICAM1, CCL5, NOD2, 
               
               
                   
                   
                   
                   
                 226066_AT, 223502_S_AT, 
                 CD55, CD55, ICAM1 
               
               
                   
                   
                   
                   
                 218559_S_AT, 207433_AT, 
                   
               
               
                   
                   
                   
                   
                 202637_S_AT, 1555759_A_AT, 
                   
               
               
                   
                   
                   
                   
                 220066_AT, 201926_S_AT, 
                   
               
               
                   
                   
                   
                   
                 1555950_A_AT, 202638_S_AT 
                   
               
               
                 GO:0048518~positive 
                 1.62E−05 
                 2.290466213 
                 0.001326312 
                 213891_S_AT, 209555_S_AT, 
                 TCF4, CD36, MALT1, P2RX4, CD40, NFKBIA, 
               
               
                 regulation of biological 
                   
                   
                   
                 210017_AT, 204088_AT, 
                 CD40, PRDM1, GHRL, IL7R, TCF4, CCL2, MAFB, 
               
               
                 process 
                   
                   
                   
                 205153_S_AT, 201502_S_AT, 215346_AT, 
                 HNRPLL, BID, IL10, MMP9, NOD2, SOD2, CD55, 
               
               
                   
                   
                   
                   
                 228964_AT, 223862_AT, 
                 CD55, SOD2, ADAM9, TNFRSF9, FABP4, CD14, 
               
               
                   
                   
                   
                   
                 226218_AT, 212387_AT, 
                 BID, SRA1, MITF, TNFSF13B, PTX3, EGF, SOD2, 
               
               
                   
                   
                   
                   
                 216598_S_AT, 218559_S_AT, 
                 ICAM1, CCL5, BID, ICAM1 
               
               
                   
                   
                   
                   
                 225386_S_AT, 227143_S_AT, 
                   
               
               
                   
                   
                   
                   
                 207433_AT, 203936_S_AT, 
                   
               
               
                   
                   
                   
                   
                 220066_AT, 221477_S_AT, 
                   
               
               
                   
                   
                   
                   
                 201926_S_AT, 1555950_A_AT, 
                   
               
               
                   
                   
                   
                   
                 215223_S_AT, 202381_AT, 207536_S_AT, 
                   
               
               
                   
                   
                   
                   
                 203980_AT, 201743_AT, 
                   
               
               
                   
                   
                   
                   
                 211725_S_AT, 224130_S_AT, 
                   
               
               
                   
                   
                   
                   
                 226066_AT, 223502_S_AT, 
                   
               
               
                   
                   
                   
                   
                 206157_AT, 206254_AT, 
                   
               
               
                   
                   
                   
                   
                 216841_S_AT, 202637_S_AT, 
                   
               
               
                   
                   
                   
                   
                 1555759_A_AT, 204493_AT, 202638_S_AT 
                   
               
               
                 GO:0051239~regulation of 
                 1.72E−05 
                 3.498329255 
                 0.001330564 
                 213503_X_AT, 210017_AT, 201743_AT, 
                 ANXA2P1, MALT1, CD14, ANXA2P2, P2RX4, 
               
               
                 multicellular organismal 
                   
                   
                   
                 208816_X_AT, 204088_AT, 
                 ANXA2P1, CD40, NFKBIA, ANXA2P1, CD40, 
               
               
                 process 
                   
                   
                   
                 210427_X_AT, 205153_S_AT, 
                 GHRL, IL7R, CCL2, MITF, MAFB, EGF, STATH, 
               
               
                   
                   
                   
                   
                 201502_S_AT, 201590_X_AT, 
                 IL10, CCL5, NOD2 
               
               
                   
                   
                   
                   
                 215346_AT, 223862_AT, 226218_AT, 
                   
               
               
                   
                   
                   
                   
                 216598_S_AT, 226066_AT, 
                   
               
               
                   
                   
                   
                   
                 218559_S_AT, 206254_AT, 
                   
               
               
                   
                   
                   
                   
                 206835_AT, 207433_AT, 
                   
               
               
                   
                   
                   
                   
                 1555759_A_AT, 220066_AT 
                   
               
               
                 GO:0060341~regulation of 
                 1.61E−05 
                 7.836801752 
                 0.001398752 
                 203927_AT, 202381_AT, 207433_AT, 
                 NFKBIE, ADAM9, IL10, RAB27B, CD40, NFKBIA, 
               
               
                 cellular localization 
                   
                   
                   
                 228708_AT, 205153_S_AT, 
                 CD40, NOD2, GHRL, EGF 
               
               
                   
                   
                   
                   
                 201502_S_AT, 215346_AT, 220066_AT, 
                   
               
               
                   
                   
                   
                   
                 223862_AT, 206254_AT 
                   
               
               
                 GO:0051046~regulation of 
                 1.57E−05 
                 9.688408808 
                 0.001446037 
                 202381_AT, 207433_AT, 228708_AT, 
                 ADAM9, IL10, RAB27B, P2RX4, CD40, CD40, 
               
               
                 secretion 
                   
                   
                   
                 204088_AT, 205153_S_AT, 
                 NOD2, GHRL, EGF 
               
               
                   
                   
                   
                   
                 215346_AT, 220066_AT, 
                   
               
               
                   
                   
                   
                   
                 223862_AT, 206254_AT 
                   
               
               
                 GO:0002822~regulation of 
                 3.26E−05 
                 15.80421687 
                 0.001846658 
                 210017_AT, 207433_AT, 205153_S_AT, 
                 MALT1, IL10, CD40, CD40, NOD2, IL7R, 
               
               
                 adaptive immune response 
                   
                   
                   
                 215346_AT, 220066_AT, 
                 TNFSF13B 
               
               
                 based on somatic 
                   
                   
                   
                 226218_AT, 223502_S_AT 
                   
               
               
                 recombination of immune 
                   
                   
                   
                   
                   
               
               
                 receptors built from 
                   
                   
                   
                   
                   
               
               
                 immunoglobulin 
                   
                   
                   
                   
                   
               
               
                 superfamily domains 
                   
                   
                   
                   
                   
               
               
                 GO:0043067~regulation of 
                 2.93E−05 
                 3.182057087 
                 0.001877378 
                 215223_S_AT, 202381_AT, 207536_S_AT, 
                 SOD2, ADAM9, TNFRSF9, MALT1, P2RX4, BID, 
               
               
                 programmed cell death 
                   
                   
                   
                 210017_AT, 204088_AT, 
                 NFKBIA, GHRL, CHST11, CCL2, MITF, TNFSF13B, 
               
               
                   
                   
                   
                   
                 211725_S_AT, 201502_S_AT, 
                 BID, SOD2, TNFAIP3, IFIH1, IL10, MMP9, SOD2, 
               
               
                   
                   
                   
                   
                 223862_AT, 219634_AT, 
                 NOD2, BID, BIRC3 
               
               
                   
                   
                   
                   
                 216598_S_AT, 226066_AT, 
                   
               
               
                   
                   
                   
                   
                 223502_S_AT, 227143_S_AT, 
                   
               
               
                   
                   
                   
                   
                 216841_S_AT, 202644_S_AT, 
                   
               
               
                   
                   
                   
                   
                 219209_AT, 207433_AT, 
                   
               
               
                   
                   
                   
                   
                 203936_S_AT, 221477_S_AT, 
                   
               
               
                   
                   
                   
                   
                 220066_AT, 204493_AT, 210538_S_AT 
                   
               
               
                 GO:0010941~regulation of 
                 3.06E−05 
                 3.171414756 
                 0.001878077 
                 215223_S_AT, 202381_AT, 207536_S_AT, 
                 SOD2, ADAM9, TNFRSF9, MALT1, P2RX4, BID, 
               
               
                 cell death 
                   
                   
                   
                 210017_AT, 204088_AT, 
                 NFKBIA, GHRL, CHST11, CCL2, MITF, TNFSF13B, 
               
               
                   
                   
                   
                   
                 211725_S_AT, 201502_S_AT, 
                 BID, SOD2, TNFAIP3, IFIH1, IL10, MMP9, SOD2, 
               
               
                   
                   
                   
                   
                 223862_AT, 219634_AT, 
                 NOD2, BID, BIRC3 
               
               
                   
                   
                   
                   
                 216598_S_AT, 226066_AT, 
                   
               
               
                   
                   
                   
                   
                 223502_S_AT, 227143_S_AT, 
                   
               
               
                   
                   
                   
                   
                 216841_S_AT, 202644_S_AT, 
                   
               
               
                   
                   
                   
                   
                 219209_AT, 207433_AT, 
                   
               
               
                   
                   
                   
                   
                 203936_S_AT, 221477_S_AT, 
                   
               
               
                   
                   
                   
                   
                 220066_AT, 204493_AT, 210538_S_AT 
                   
               
               
                 GO:0009617~response to 
                 3.20E−05 
                 8.689603776 
                 0.001886839 
                 203887_S_AT, 210017_AT, 201743_AT, 
                 THBD, MALT1, CD14, IL10, NFKBIA, CCL5, NOD2, 
               
               
                 bacterium 
                   
                   
                   
                 207433_AT, 201502_S_AT, 
                 CCL2 
               
               
                   
                   
                   
                   
                 1555759_A_AT, 220066_AT, 216598_S_AT 
                   
               
               
                 GO:0042981~regulation of 
                 2.57E−05 
                 3.21441699 
                 0.001895789 
                 215223_S_AT, 202381_AT, 207536_S_AT, 
                 SOD2, ADAM9, TNFRSF9, MALT1, P2RX4, BID, 
               
               
                 apoptosis 
                   
                   
                   
                 210017_AT, 204088_AT, 
                 NFKBIA, GHRL, CHST11, CCL2, MITF, TNFSF13B, 
               
               
                   
                   
                   
                   
                 211725_S_AT, 201502_S_AT, 
                 BID, SOD2, TNFAIP3, IFIH1, IL10, MMP9, SOD2, 
               
               
                   
                   
                   
                   
                 223862_AT, 219634_AT, 
                 NOD2, BID, BIRC3 
               
               
                   
                   
                   
                   
                 216598_S_AT, 226066_AT, 
                   
               
               
                   
                   
                   
                   
                 223502_S_AT, 227143_S_AT, 
                   
               
               
                   
                   
                   
                   
                 216841_S_AT, 202644_S_AT, 
                   
               
               
                   
                   
                   
                   
                 219209_AT, 207433_AT, 
                   
               
               
                   
                   
                   
                   
                 203936_S_AT, 221477_S_AT, 
                   
               
               
                   
                   
                   
                   
                 220066_AT, 204493_AT, 210538_S_AT 
                   
               
               
                 GO:0050776~regulation of 
                 2.88E−05 
                 7.238572611 
                 0.001926271 
                 210017_AT, 202637_S_AT, 
                 MALT1, ICAM1, IL10, CD40, NFKBIA, CD40, 
               
               
                 immune response 
                   
                   
                   
                 207433_AT, 205153_S_AT, 
                 NOD2, CD55, IL7R, TNFSF13B, ICAM1, CD55 
               
               
                   
                   
                   
                   
                 201502_S_AT, 215346_AT, 220066_AT, 
                   
               
               
                   
                   
                   
                   
                 201926_S_AT, 226218_AT, 
                   
               
               
                   
                   
                   
                   
                 223502_S_AT, 202638_S_AT, 1555950_A_AT 
                   
               
               
                 GO:0048513~organ 
                 2.80E−05 
                 2.616968956 
                 0.001962303 
                 219358_S_AT, 213503_X_AT, 
                 ADAP2, ANXA2P1, MALT1, ANXA2P1, PRDM1, 
               
               
                 development 
                   
                   
                   
                 210017_AT, 210427_X_AT, 
                 PLAUR, GHRL, VPS33A, IL7R, CCL2, MAFB, 
               
               
                   
                   
                   
                   
                 228964_AT, 214866_AT, 223862_AT, 
                 STATH, TGM5, IL10, MMP9, SOD2, GPR183, 
               
               
                   
                   
                   
                   
                 204590_X_AT, 226218_AT, 
                 CRYBB2, SOD2, ADAM9, ANXA2P2, ANXA2P1, 
               
               
                   
                   
                   
                   
                 216598_S_AT, 218559_S_AT, 
                 CHST11, MITF, EGF, SOD2, MLF1 
               
               
                   
                   
                   
                   
                 206835_AT, 207911_S_AT, 
                   
               
               
                   
                   
                   
                   
                 207433_AT, 203936_S_AT, 
                   
               
               
                   
                   
                   
                   
                 221477_S_AT, 205419_AT, 
                   
               
               
                   
                   
                   
                   
                 206777_S_AT, 215223_S_AT, 
                   
               
               
                   
                   
                   
                   
                 202381_AT, 208816_X_AT, 
                   
               
               
                   
                   
                   
                   
                 201590_X_AT, 219634_AT, 226066_AT, 
                   
               
               
                   
                   
                   
                   
                 206254_AT, 216841_S_AT, 204784_S_AT 
                   
               
               
                 GO:0002819~regulation of 
                 3.69E−05 
                 15.41874816 
                 0.002010277 
                 210017_AT, 207433_AT, 205153_S_AT, 
                 MALT1, IL10, CD40, CD40, NOD2, IL7R, 
               
               
                 adaptive immune response 
                   
                   
                   
                 215346_AT, 220066_AT, 
                 TNFSF13B 
               
               
                   
                   
                   
                   
                 226218_AT, 223502_S_AT 
                   
               
               
                 GO:0009605~response to 
                 4.27E−05 
                 3.433366869 
                 0.002243592 
                 215223_S_AT, 209555_S_AT, 
                 SOD2, CD36, CD14, CD40, PLAUR, CD40, 
               
               
                 external stimulus 
                   
                   
                   
                 201743_AT, 205153_S_AT, 
                 TNFAIP6, GHRL, CCL2, PTX3, SOD2, THBD, IL10, 
               
               
                   
                   
                   
                   
                 214866_AT, 215346_AT, 206026_S_AT, 
                 CCL5, SOD2, NOD2, KYNU, CD9, CD55, KYNU, 
               
               
                   
                   
                   
                   
                 223862_AT, 216598_S_AT, 
                 CD55 
               
               
                   
                   
                   
                   
                 206157_AT, 216841_S_AT, 
                   
               
               
                   
                   
                   
                   
                 203887_S_AT, 207433_AT, 
                   
               
               
                   
                   
                   
                   
                 1555759_A_AT, 221477_S_AT, 
                   
               
               
                   
                   
                   
                   
                 220066_AT, 210663_S_AT, 
                   
               
               
                   
                   
                   
                   
                 201005_AT, 201926_S_AT, 
                   
               
               
                   
                   
                   
                   
                 217388_S_AT, 1555950_A_AT 
                   
               
               
                 GO:0045428~regulation of 
                 4.62E−05 
                 23.94578313 
                 0.002345211 
                 215223_S_AT, 216841_S_AT, 
                 SOD2, SOD2, ICAM1, IL10, P2RX4, SOD2, ICAM1, 
               
               
                 nitric oxide biosynthetic 
                   
                   
                   
                 202637_S_AT, 207433_AT, 
                 PTX3 
               
               
                 process 
                   
                   
                   
                 204088_AT, 221477_S_AT, 
                   
               
               
                   
                   
                   
                   
                 202638_S_AT, 206157_AT 
                   
               
               
                 GO:0051223~regulation of 
                 5.39E−05 
                 10.2434739 
                 0.002644616 
                 203927_AT, 202381_AT, 207433_AT, 
                 NFKBIE, ADAM9, IL10, CD40, NFKBIA, CD40, 
               
               
                 protein transport 
                   
                   
                   
                 205153_S_AT, 201502_S_AT, 
                 NOD2, EGF 
               
               
                   
                   
                   
                   
                 215346_AT, 220066_AT, 206254_AT 
                   
               
               
                 GO:0009607~response to 
                 5.71E−05 
                 4.995585791 
                 0.002709622 
                 203887_S_AT, 210017_AT, 201743_AT, 
                 THBD, MALT1, CD14, IFH1, IL10, NFKBIA, CCL5, 
               
               
                 biotic stimulus 
                   
                   
                   
                 219209_AT, 207433_AT, 
                 NOD2, IFNGR1, CCL2, PTX3 
               
               
                   
                   
                   
                   
                 201502_S_AT, 1555759_A_AT, 
                   
               
               
                   
                   
                   
                   
                 220066_AT, 211676_S_AT, 
                   
               
               
                   
                   
                   
                   
                 216598_S_AT, 206157_AT 
                   
               
               
                 GO:0005615~extracellular 
                 7.88E−05 
                 4.831639194 
                 0.00308733 
                 202381_AT, 203887_S_AT, 202637_S_AT, 
                 ADAM9, THBD, ICAM1, IL10, FGL2, MMP9, 
               
               
                 space 
                   
                   
                   
                 207433_AT, 227265_AT, 
                 CCL5, GHRL, CCL2, TNFSF13B, ICAM1, EGF 
               
               
                   
                   
                   
                   
                 203936_S_AT, 1555759_A_AT, 
                   
               
               
                   
                   
                   
                   
                 223862_AT, 216598_S_AT, 
                   
               
               
                   
                   
                   
                   
                 223502_S_AT, 202638_S_AT, 206254_AT 
                   
               
               
                 GO:0051241~negative 
                 7.32E−05 
                 9.704343691 
                 0.0033662 
                 206835_AT, 213503_X_AT, 208816_X_AT, 
                 STATH, ANXA2P1, ANXA2P2, IL10, P2RX4, 
               
               
                 regulation of multicellular 
                   
                   
                   
                 207433_AT, 204088_AT, 
                 ANXA2P1, ANXA2P1, NOD2, GHRL 
               
               
                 organismal process 
                   
                   
                   
                 210427_X_AT, 201590_X_AT, 
                   
               
               
                   
                   
                   
                   
                 220066_AT, 223862_AT 
                   
               
               
                 GO:0032101~regulation of 
                 8.47E−05 
                 9.455514365 
                 0.00366669 
                 213503_X_AT, 203980_AT, 
                 ANXA2P1, FABP4, ANXA2P2, IL10, ANXA2P1, 
               
               
                 response to external 
                   
                   
                   
                 208816_X_AT, 207433_AT, 
                 ANXA2P1, CCL5, GHRL, NT5E 
               
               
                 stimulus 
                   
                   
                   
                 210427_X_AT, 201590_X_AT, 
                   
               
               
                   
                   
                   
                   
                 1555759_A_AT, 223862_AT, 203939 AT 
                   
               
               
                 GO:0070201~regulation of 
                 8.47E−05 
                 9.455514365 
                 0.00366669 
                 203927_AT, 202381_AT, 207433_AT, 
                 NFKBIE, ADAM9, IL10, CD40, NFKBIA, CD40, 
               
               
                 establishment of protein 
                   
                   
                   
                 205153_S_AT, 201502_S_AT, 
                 NOD2, EGF 
               
               
                 localization 
                   
                   
                   
                 215346_AT, 220066_AT, 206254_AT 
                   
               
               
                 GO:0050793~regulation of 
                 8.33E−05 
                 3.669304082 
                 0.003713809 
                 215223_S_AT, 202381_AT, 
                 SOD2, ADAM9, CD36, CD40, NFKBIA, CD40, 
               
               
                 developmental process 
                   
                   
                   
                 209555_S_AT, 205153_S_AT, 
                 GHRL, VPS33A, IL7R, MITF, MAFB, EGF, SOD2, 
               
               
                   
                   
                   
                   
                 201502_S_AT, 215346_AT, 223862_AT, 
                 STATH, IL10, CCL5, SOD2 
               
               
                   
                   
                   
                   
                 204590_X_AT, 226218_AT, 
                   
               
               
                   
                   
                   
                   
                 226066_AT, 218559_S_AT, 206254_AT, 
                   
               
               
                   
                   
                   
                   
                 216841_S_AT, 206835_AT, 
                   
               
               
                   
                   
                   
                   
                 207433_AT, 1555759_A_AT, 221477_S_AT 
                   
               
               
                 GO:0048522~positive 
                 9.67E−05 
                 2.22534329 
                 0.00406592 
                 213891_S_AT, 209555_S_AT, 
                 TCF4, CD36, MALT1, P2RX4, CD40, NFKBIA, 
               
               
                 regulation of cellular 
                   
                   
                   
                 210017_AT, 204088_AT, 
                 CD40, GHRL, IL7R, TCF4, CCL2, MAFB, HNRPLL, 
               
               
                 process 
                   
                   
                   
                 205153_S_AT, 201502_S_AT, 215346_AT, 
                 BID, IL10, MMP9, NOD2, SOD2, SOD2, ADAM9, 
               
               
                   
                   
                   
                   
                 223862_AT, 226218_AT, 
                 TNFRSF9, FABP4, BID, SRA1, MITF, TNFSF13B, 
               
               
                   
                   
                   
                   
                 212387_AT, 216598_S_AT, 
                 EGF, PTX3, SOD2, ICAM1, CCL5, BID, ICAM1 
               
               
                   
                   
                   
                   
                 218559_S_AT, 225386_S_AT, 
                   
               
               
                   
                   
                   
                   
                 227143_S_AT, 207433_AT, 
                   
               
               
                   
                   
                   
                   
                 203936_S_AT, 220066_AT, 
                   
               
               
                   
                   
                   
                   
                 221477_S_AT, 215223_S_AT, 
                   
               
               
                   
                   
                   
                   
                 202381_AT, 207536_S_AT, 
                   
               
               
                   
                   
                   
                   
                 203980_AT, 211725_S_AT, 
                   
               
               
                   
                   
                   
                   
                 224130_S_AT, 226066_AT, 
                   
               
               
                   
                   
                   
                   
                 223502_S_AT, 206254_AT, 
                   
               
               
                   
                   
                   
                   
                 206157_AT, 216841_S_AT, 
                   
               
               
                   
                   
                   
                   
                 202637_S_AT, 1555759_A_AT, 
                   
               
               
                   
                   
                   
                   
                 204493_AT, 202638_S_AT 
                   
               
               
                 GO:0032501~multicellular 
                 0.000104285 
                 1.860570435 
                 0.004260994 
                 219358_S_AT, 213503_X_AT, 
                 ADAP2, ANXA2P1, CD36, MALT1, ANXA2P1, 
               
               
                 organismal process 
                   
                   
                   
                 209555_S_AT, 210017_AT, 
                 P2RX4, CD40, PLAUR, PRDM1, CD40, VPS33A, 
               
               
                   
                   
                   
                   
                 210427_X_AT, 204088_AT, 205153_S_AT, 
                 GHRL, IL7R, CCL2, MAFB, DAB2, STATH, TGM5, 
               
               
                   
                   
                   
                   
                 214866_AT, 228964_AT, 
                 IL10, MMP9, GPR183, NOD2, SOD2, MMP1, 
               
               
                   
                   
                   
                   
                 215346_AT, 204590_X_AT, 223862_AT, 
                 BIRC3, CRYBB2, SOD2, ADAM9, FABP4, 
               
               
                   
                   
                   
                   
                 226218_AT, 216598_S_AT, 
                 ANXA2P2, ANXA2P1, CHST11, MITF, EGF, 
               
               
                   
                   
                   
                   
                 218559_S_AT, 201278_AT, 206835_AT, 
                 AKR1C2, MXD1, SOD2, THBD, MLF1, CD9 
               
               
                   
                   
                   
                   
                 207911_S_AT, 207433_AT, 
                   
               
               
                   
                   
                   
                   
                 203936_S_AT, 205419_AT, 220066_AT, 
                   
               
               
                   
                   
                   
                   
                 221477_S_AT, 204475_AT, 
                   
               
               
                   
                   
                   
                   
                 210538_S_AT, 206777_S_AT, 
                   
               
               
                   
                   
                   
                   
                 215223_S_AT, 202381_AT, 
                   
               
               
                   
                   
                   
                   
                 203980_AT, 208816_X_AT, 201590_X_AT, 
                   
               
               
                   
                   
                   
                   
                 219634_AT, 226066_AT, 
                   
               
               
                   
                   
                   
                   
                 206254_AT, 211653_X_AT, 
                   
               
               
                   
                   
                   
                   
                 226275_AT, 216841_S_AT, 
                   
               
               
                   
                   
                   
                   
                 203887_S_AT, 204784_S_AT, 201005_AT 
                   
               
               
                 GO:0007166-cell surface 
                 0.000113804 
                 2.856183771 
                 0.004523702 
                 218589_AT, 202381_AT, 210017_AT, 
                 LPAR6, ADAM9, MALT1, CD14, CD40, NFKBIA, 
               
               
                 receptor linked signal 
                   
                   
                   
                 201743_AT, 205153_S_AT, 
                 CD40, GHRL, MTSS1, IL7R, CCL2, MITF, EGF, 
               
               
                 transduction 
                   
                   
                   
                 201502_S_AT, 215346_AT, 223862_AT, 
                 ADAMDEC1, CCL5, GPR183, GPR34, ITGB5, 
               
               
                   
                   
                   
                   
                 203037_S_AT, 226218_AT, 
                 BIRC3 
               
               
                   
                   
                   
                   
                 216598_S_AT, 226066_AT, 
                   
               
               
                   
                   
                   
                   
                 206254_AT, 206134_AT, 
                   
               
               
                   
                   
                   
                   
                 1555759_A_AT, 205419_AT, 
                   
               
               
                   
                   
                   
                   
                 244434_AT, 201125_S_AT, 210538_S_AT 
                   
               
               
                 GO:0006916~anti- 
                 0.000124449 
                 5.889770261 
                 0.004815965 
                 215223_S_AT, 216841_S_AT, 
                 SOD2, SOD2, TNFAIP3, MALT1, IL10, NFKBIA, 
               
               
                 apoptosis 
                   
                   
                   
                 202644_S_AT, 210017_AT, 
                 SOD2, GHRL, CCL2, TNFSF13B, BIRC3 
               
               
                   
                   
                   
                   
                 207433_AT, 201502_S_AT, 
                   
               
               
                   
                   
                   
                   
                 221477_S_AT, 223862_AT, 
                   
               
               
                   
                   
                   
                   
                 216598_S_AT, 223502_S_AT, 210538_S_AT 
                   
               
               
                 GO:0043066~negative 
                 0.000129722 
                 4.527249623 
                 0.004891125 
                 215223_S_AT, 210017_AT, 201502_S_AT, 
                 SOD2, MALT1, NFKBIA, GHRL, CHST11, CCL2, 
               
               
                 regulation of apoptosis 
                   
                   
                   
                 223862_AT, 219634_AT, 
                 MITF, TNFSF13B, SOD2, TNFAIP3, IL10, SOD2, 
               
               
                   
                   
                   
                   
                 216598_S_AT, 226066_AT, 
                 BIRC3 
               
               
                   
                   
                   
                   
                 223502_S_AT, 216841_S_AT, 
                   
               
               
                   
                   
                   
                   
                 202644_S_AT, 207433_AT, 
                   
               
               
                   
                   
                   
                   
                 221477_S_AT, 210538_S_AT 
                   
               
               
                 GO:0060548~negative 
                 0.000147362 
                 4.457599629 
                 0.005158736 
                 215223_S_AT, 210017_AT, 201502_S_AT, 
                 SOD2, MALT1, NFKBIA, GHRL, CHST11, CCL2, 
               
               
                 regulation of cell death 
                   
                   
                   
                 223862_AT, 219634_AT, 
                 MITF, TNFSF13B, SOD2, TNFAIP3, IL10, SOD2, 
               
               
                   
                   
                   
                   
                 216598_S_AT, 226066_AT, 
                 BIRC3 
               
               
                   
                   
                   
                   
                 223502_S_AT, 216841_S_AT, 
                   
               
               
                   
                   
                   
                   
                 202644_S_AT, 207433_AT, 
                   
               
               
                   
                   
                   
                   
                 221477_S_AT, 210538_S_AT 
                   
               
               
                 GO:0043069~negative 
                 0.000142772 
                 4.474810439 
                 0.005247712 
                 215223_S_AT, 210017_AT, 201502_S_AT, 
                 SOD2, MALT1, NFKBIA, GHRL, CHST11, CCL2, 
               
               
                 regulation of programmed 
                   
                   
                   
                 223862_AT, 219634_AT, 
                 MITF, TNFSF13B, SOD2, TNFAIP3, IL10, SOD2, 
               
               
                 cell death 
                   
                   
                   
                 216598_S_AT, 226066_AT, 
                 BIRC3 
               
               
                   
                   
                   
                   
                 223502_S_AT, 216841_S_AT, 
                   
               
               
                   
                   
                   
                   
                 202644_S_AT, 207433_AT, 
                   
               
               
                   
                   
                   
                   
                 221477_S_AT, 210538_S_AT 
                   
               
               
                 GO:0009893~positive 
                 0.000147162 
                 2.926706827 
                 0.005277077 
                 213891_S_AT, 215223_S_AT, 
                 TCF4, SOD2, ADAM9, P2RX4, CD40, NFKBIA, 
               
               
                 regulation of metabolic 
                   
                   
                   
                 202381_AT, 204088_AT, 
                 SRA1, CD40, PRDM1, TCF4, MITF, TNFSF13B, 
               
               
                 process 
                   
                   
                   
                 205153_S_AT, 201502_S_AT, 
                 MAFB, EGF, PTX3, HNRPLL, SOD2, ICAM1, IL10, 
               
               
                   
                   
                   
                   
                 224130_S_AT, 215346_AT, 
                 SOD2, NOD2, ICAM1 
               
               
                   
                   
                   
                   
                 228964_AT, 212387_AT, 226066_AT, 
                   
               
               
                   
                   
                   
                   
                 223502_S_AT, 218559_S_AT, 
                   
               
               
                   
                   
                   
                   
                 206254_AT, 206157_AT, 
                   
               
               
                   
                   
                   
                   
                 225386_S_AT, 216841_S_AT, 
                   
               
               
                   
                   
                   
                   
                 202637_S_AT, 207433_AT, 
                   
               
               
                   
                   
                   
                   
                 221477_S_AT, 220066_AT, 202638_S_AT 
                   
               
               
                 GO:0031347~regulation of 
                 0.000165947 
                 8.381024096 
                 0.005672844 
                 203980_AT, 207433_AT, 
                 FABP4, IL10, NFKBIA, CCL5, NOD2, GHRL, NT5E 
               
               
                 defense response 
                   
                   
                   
                 201502_S_AT, 1555759_A_AT, 
                   
               
               
                   
                   
                   
                   
                 220066_AT, 223862_AT, 203939_AT 
                   
               
               
                 GO:0006952~defense 
                 0.000177009 
                 3.963439967 
                 0.005912766 
                 210017_AT, 201743_AT, 205153_S_AT, 
                 MALT1, CD14, CD40, TNFAIP6, CD40, CCL2, 
               
               
                 response 
                   
                   
                   
                 206026_S_AT, 215346_AT, 
                 PTX3, IFIH1, IL10, CCL5, NOD2, KYNU, CD55, 
               
               
                   
                   
                   
                   
                 216598_S_AT, 206157_AT, 
                 KYNU, CD55 
               
               
                   
                   
                   
                   
                 219209_AT, 207433_AT, 
                   
               
               
                   
                   
                   
                   
                 1555759_A_AT, 220066_AT, 
                   
               
               
                   
                   
                   
                   
                 210663_S_AT, 201926_S_AT, 
                   
               
               
                   
                   
                   
                   
                 217388_S_AT, 1555950_A_AT 
                   
               
               
                 GO:0050708~regulation of 
                 0.000186347 
                 16.99378158 
                 0.00608588 
                 202381_AT, 207433_AT, 205153_S_AT, 
                 ADAM9, IL10, CD40, CD40, NOD2, EGF 
               
               
                 protein secretion 
                   
                   
                   
                 215346_AT, 220066_AT, 206254_AT 
                   
               
               
                 GO:0051704~multi- 
                 0.000215223 
                 3.337240364 
                 0.006727739 
                 210017_AT, 201743_AT, 201502_S_AT, 
                 MALT1, CD14, NFKBIA, GHRL, IFNGR1, CCL2, 
               
               
                 organism process 
                   
                   
                   
                 223862_AT, 211676_S_AT, 
                 PTX3, THBD, ICAM1, IL10, IFIH1, CCL5, NOD2, 
               
               
                   
                   
                   
                   
                 216598_S_AT, 206157_AT, 
                 MMP1, ICAM1 
               
               
                   
                   
                   
                   
                 203887_S_AT, 202637_S_AT, 
                   
               
               
                   
                   
                   
                   
                 207433_AT, 219209_AT, 1555759_A_AT, 
                   
               
               
                   
                   
                   
                   
                 220066_AT, 204475_AT, 202638_S_AT 
                   
               
               
                 GO:0032880~regulation of 
                 0.00021195 
                 8.016631744 
                 0.006769334 
                 203927_AT, 202381_AT, 207433_AT, 
                 NFKBIE, ADAM9, IL10, CD40, NFKBIA, CD40, 
               
               
                 protein localization 
                   
                   
                   
                 205153_S_AT, 201502_S_AT, 
                 NOD2, EGF 
               
               
                   
                   
                   
                   
                 215346_AT, 220066_AT, 206254_AT 
                   
               
               
                 GO:0002697~regulation of 
                 0.000233713 
                 10.53614458 
                 0.007006643 
                 210017_AT, 202637_S_AT, 207433_AT, 
                 MALT1, ICAM1, IL10, CD40, CD40, NOD2, IL7R, 
               
               
                 immune effector process 
                   
                   
                   
                 205153_S_AT, 215346_AT, 
                 ICAM1 
               
               
                   
                   
                   
                   
                 220066_AT, 226218_AT, 202638_S_AT 
                   
               
               
                 GO:0002706~regulation of 
                 0.000238915 
                 15.96385542 
                 0.007019318 
                 210017_AT, 207433_AT, 205153_S_AT, 
                 MALT1, IL10, CD40, CD40, NOD2, IL7R 
               
               
                 lymphocyte mediated 
                   
                   
                   
                 215346_AT, 220066_AT, 226218_AT 
                   
               
               
                 immunity 
                   
                   
                   
                   
                   
               
               
                 GO:0080134~regulation of 
                 0.000230106 
                 5.387801205 
                 0.007042074 
                 213503_X_AT, 203980_AT, 
                 ANXA2P1, FABP4, ANXA2P2, IL10, ANXA2P1, 
               
               
                 response to stress 
                   
                   
                   
                 208816_X_AT, 207433_AT, 
                 NFKBIA, ANXA2P1, CCL5, NOD2, GHRL, NT5E 
               
               
                   
                   
                   
                   
                 210427_X_AT, 201502_S_AT, 
                   
               
               
                   
                   
                   
                   
                 201590_X_AT, 1555759_A_AT, 
                   
               
               
                   
                   
                   
                   
                 220066_AT, 223862_AT, 203939_AT 
                   
               
               
                 GO:0032502~developmental 
                 0.000273185 
                 1.891259305 
                 0.007865563 
                 219358_S_AT, 213503_X_AT, 
                 ADAP2, ANXA2P1, MALT1, ANXA2P1, PLAUR, 
               
               
                 process 
                   
                   
                   
                 210017_AT, 210427_X_AT, 
                 PRDM1, VPS33A, GHRL, IL7R, CCL2, MAFB, 
               
               
                   
                   
                   
                   
                 214866_AT, 228964_AT, 204590_X_AT, 
                 DAB2, TGM5, STATH, IL10, MMP9, SOD2, 
               
               
                   
                   
                   
                   
                 223862_AT, 226218_AT, 
                 GPR183, SOD2, CRYBB2, ADAM9, FABP4, 
               
               
                   
                   
                   
                   
                 216598_S_AT, 218559_S_AT, 
                 ANXA2P2, ANXA2P1, SRA1, CAST, CHST11, 
               
               
                   
                   
                   
                   
                 201278_AT, 207911_S_AT, 
                 MITF, EGF, MXD1, SOD2, THBD, MLF1, CCL5, 
               
               
                   
                   
                   
                   
                 206835_AT, 207433_AT, 203936_S_AT, 
                 CD9 
               
               
                   
                   
                   
                   
                 221477_S_AT, 205419_AT, 
                   
               
               
                   
                   
                   
                   
                 215223_S_AT, 206777_S_AT, 
                   
               
               
                   
                   
                   
                   
                 202381_AT, 203980_AT, 
                   
               
               
                   
                   
                   
                   
                 208816_X_AT, 201590_X_AT, 
                   
               
               
                   
                   
                   
                   
                 224130_S_AT, 208908_S_AT, 
                   
               
               
                   
                   
                   
                   
                 219634_AT, 226066_AT, 206254_AT, 
                   
               
               
                   
                   
                   
                   
                 226275_AT, 216841_S_AT, 
                   
               
               
                   
                   
                   
                   
                 203887_S_AT, 204784_S_AT, 
                   
               
               
                   
                   
                   
                   
                 1555759_A_AT, 201005_AT 
                   
               
               
                 GO:0048584~positive 
                 0.000283953 
                 6.152493184 
                 0.008017793 
                 210017_AT, 203980_AT, 
                 MALT1, FABP4, NFKBIA, CCL5, NOD2, GHRL, 
               
               
                 regulation of response to 
                   
                   
                   
                 201502_S_AT, 1555759_A_AT, 
                 CD55,TNFSF13B, CD55 
               
               
                 stimulus 
                   
                   
                   
                 220066_AT, 223862_AT, 
                   
               
               
                   
                   
                   
                   
                 201926_S_AT, 223502_S_AT, 1555950_A_AT 
                   
               
               
                 GO:0007155~cell adhesion 
                 0.000307737 
                 3.718639263 
                 0.008523348 
                 209933_S_AT, 213428_S_AT, 
                 CD300A, COL6A1, ADAM9, CD36, TNFAIP6, 
               
               
                   
                   
                   
                   
                 202381_AT, 209555_S_AT, 
                 MTSS1, CCL2, LPXN, ICAM1, CCL5, ITGB5, CD9, 
               
               
                   
                   
                   
                   
                 206026_S_AT, 203037_S_AT, 
                 ICAM1 
               
               
                   
                   
                   
                   
                 216598_S_AT, 216250_S_AT, 
                   
               
               
                   
                   
                   
                   
                 202637_S_AT, 1555759_A_AT, 
                   
               
               
                   
                   
                   
                   
                 201125_S_AT, 201005_AT, 202638_S_AT 
                   
               
               
                 GO:0022610~biologieal 
                 0.000315533 
                 3.707734162 
                 0.008578876 
                 209933_S_AT, 213428_S_AT, 
                 CD300A, COL6A1, ADAM9, CD36, TNFAIP6, 
               
               
                 adhesion 
                   
                   
                   
                 202381_AT, 209555_S_AT, 
                 MTSS1, CCL2, LPXN, ICAM1, CCL5, ITGB5, CD9, 
               
               
                   
                   
                   
                   
                 206026_S_AT, 203037_S_AT, 
                 ICAM1 
               
               
                   
                   
                   
                   
                 216598_S_AT, 216250_S_AT, 
                   
               
               
                   
                   
                   
                   
                 202637_S_AT, 1555759_A_AT, 
                   
               
               
                   
                   
                   
                   
                 201125_S_AT, 201005_AT, 202638_S_AT 
                   
               
               
                 GO:0002684~positive 
                 0.000324184 
                 6.020654045 
                 0.008651889 
                 210017_AT, 202637_S_AT, 
                 MALT1, ICAM1, CD40, NFKBIA, CD40, NOD2, 
               
               
                 regulation of immune 
                   
                   
                   
                 205153_S_AT, 201502_S_AT, 
                 CD55, IL7R, TNFSF13B, ICAM1, CD55 
               
               
                 system process 
                   
                   
                   
                 215346_AT, 220066_AT, 201926_S_AT, 
                   
               
               
                   
                   
                   
                   
                 226218_AT, 223502_S_AT, 
                   
               
               
                   
                   
                   
                   
                 202638_S_AT, 1555950_A_AT 
                   
               
               
                 GO:0001775~cell activation 
                 0.000386538 
                 4.990805327 
                 0.010124588 
                 202381_AT, 210017_AT, 202637_S_AT, 
                 ADAM9, MALT1, ICAM1, IL10, P2RX4, CD40, 
               
               
                   
                   
                   
                   
                 207433_AT, 204088_AT, 
                 CD40, GPR183, CD9, IL7R, ICAM1 
               
               
                   
                   
                   
                   
                 205153_S_AT, 215346_AT, 205419_AT, 
                   
               
               
                   
                   
                   
                   
                 201005_AT, 226218_AT, 202638_S_AT 
                   
               
               
                 GO:0045429~positive 
                 0.000407508 
                 26.34036145 
                 0.010484798 
                 215223_S_AT, 216841_S_AT, 
                 SOD2, SOD2, ICAM1, P2RX4, SOD2, ICAM1, 
               
               
                 regulation of nitric oxide 
                   
                   
                   
                 202637_S_AT, 204088_AT, 
                 PTX3 
               
               
                 biosynthetic process 
                   
                   
                   
                 221477_S_AT, 202638_S_AT, 206157_AT 
                   
               
               
                 GO:0002703~regulation of 
                 0.00041591 
                 13.86334813 
                 0.01051636 
                 210017_AT, 207433_AT, 205153_S_AT, 
                 MALT1, IL10, CD40, CD40, NOD2, IL7R 
               
               
                 leukocyte mediated 
                   
                   
                   
                 215346_AT, 220066_AT, 226218_AT 
                   
               
               
                 immunity 
                   
                   
                   
                   
                   
               
               
                 GO:0048856~anatomical 
                 0.000458417 
                 2.018715984 
                 0.011389929 
                 219358_S_AT, 213503_X_AT, 
                 ADAP2, ANXA2P1, MALT1, ANXA2P1, PRDM1, 
               
               
                 structure development 
                   
                   
                   
                 210017_AT, 210427_X_AT, 
                 PLAUR, VPS33A, GHRL, IL7R, CCL2, MAFB, DAB2, 
               
               
                   
                   
                   
                   
                 228964_AT, 214866_AT, 204590_X_AT, 
                 TGM5, STATH, IL10, MMP9, SOD2, GPR183, 
               
               
                   
                   
                   
                   
                 223862_AT, 226218_AT, 
                 SOD2, CRYBB2, ADAM9, ANXA2P2, ANXA2P1, 
               
               
                   
                   
                   
                   
                 216598_S_AT, 212559_S_AT, 
                 CAST, CHST11, MITF, EGF, SOD2, MLF1, CD9 
               
               
                   
                   
                   
                   
                 201278_AT, 207911_S_AT, 
                   
               
               
                   
                   
                   
                   
                 206835_AT, 207433_AT, 203936_S_AT, 
                   
               
               
                   
                   
                   
                   
                 221477_S_AT, 205419_AT, 
                   
               
               
                   
                   
                   
                   
                 215223_S_AT, 206777_S_AT, 
                   
               
               
                   
                   
                   
                   
                 202381_AT, 208816_X_AT, 
                   
               
               
                   
                   
                   
                   
                 201590_X_AT, 208908_S_AT, 219634_AT, 
                   
               
               
                   
                   
                   
                   
                 226066_AT, 206254_AT, 
                   
               
               
                   
                   
                   
                   
                 216841_S_AT, 204784_S_AT, 201005_AT 
                   
               
               
                 GO:0046903~secretion 
                 0.000554725 
                 5.509095204 
                 0.013539046 
                 201278_AT, 206835_AT, 
                 DAB2, STATH, ANXA2P1, ANXA2P2, ANXA2P1, 
               
               
                   
                   
                   
                   
                 213503_X_AT, 208816_X_AT, 
                 ANXA2P1, CCL5, VPS33A, GHRL, TNFSF13B 
               
               
                   
                   
                   
                   
                 210427_X_AT, 201590_X_AT, 
                   
               
               
                   
                   
                   
                   
                 1555759_A_AT, 204590_X_AT, 
                   
               
               
                   
                   
                   
                   
                 223862_AT, 223502_S_AT 
                   
               
               
                 GO:0050727~regulation of 
                 0.000612986 
                 12.54302926 
                 0.01470747 
                 203980_AT, 207433_AT, 1555759_A_AT, 
                 FABP4, IL10, CCL5, GHRL, NT5E 
               
               
                 inflammatory response 
                   
                   
                   
                 223862_AT, 203939_AT 
                   
               
               
                 GO:0048731~system 
                 0.000635394 
                 2.065910702 
                 0.014997197 
                 219358_S_AT, 213503_X_AT, 
                 ADAP2, ANXA2P1, MALT1, ANXA2P1, PRDM1, 
               
               
                 development 
                   
                   
                   
                 210017_AT, 210427_X_AT, 
                 PLAUR, GHRL, VPS33A, IL7R, CCL2, MAFB, 
               
               
                   
                   
                   
                   
                 228964_AT, 214866_AT, 223862_AT, 
                 STATH, TGM5, IL10, MMP9, SOD2, GPR183, 
               
               
                   
                   
                   
                   
                 204590_X_AT, 226218_AT, 
                 SOD2, CRYBB2, ADAM9, ANXA2P2, ANXA2P1, 
               
               
                   
                   
                   
                   
                 216598_S_AT, 218559_S_AT, 
                 CHST11, MITF, EGF, SOD2, MLF1, CD9 
               
               
                   
                   
                   
                   
                 206835_AT, 207911_S_AT, 
                   
               
               
                   
                   
                   
                   
                 207433_AT, 203936_S_AT, 
                   
               
               
                   
                   
                   
                   
                 221477_S_AT, 205419_AT, 
                   
               
               
                   
                   
                   
                   
                 215223_S_AT, 206777_S_AT, 
                   
               
               
                   
                   
                   
                   
                 202381_AT, 208816_X_AT, 
                   
               
               
                   
                   
                   
                   
                 201590_X_AT, 219634_AT, 226066_AT, 
                   
               
               
                   
                   
                   
                   
                 206254_AT, 216841_S_AT, 
                   
               
               
                   
                   
                   
                   
                 204784_S_AT, 201005_AT 
                   
               
               
                 GO:0031226~intrinsic to 
                 0.000511383 
                 2.901401351 
                 0.015933223 
                 202381_AT, 207536_S_AT, 
                 ADAM9, TNFRSF9, CD36, P2RX4, FXYD2, CD40, 
               
               
                 plasma membrane 
                   
                   
                   
                 209555_S_AT, 204088_AT, 
                 CD40, IFNGR1, THBD, ICAM1, GPR183, CD9, 
               
               
                   
                   
                   
                   
                 207434_S_AT, 205153_S_AT, 
                 CD55, ITGB5, GPR34, CD55, STEAP1, ICAM1 
               
               
                   
                   
                   
                   
                 215346_AT, 211676_S_AT, 
                   
               
               
                   
                   
                   
                   
                 203887_S_AT, 202637_S_AT, 
                   
               
               
                   
                   
                   
                   
                 205419_AT, 201005_AT, 
                   
               
               
                   
                   
                   
                   
                 201926_S_AT, 201125_S_AT, 
                   
               
               
                   
                   
                   
                   
                 244434_AT, 1555950_A_AT, 
                   
               
               
                   
                   
                   
                   
                 205542_AT, 202638_S_AT 
                   
               
               
                 GO:0051051~negative 
                 0.00074669 
                 8.209982788 
                 0.017324877 
                 203927_AT, 200760_S_AT, 207433_AT, 
                 NFKBIE, ARL6IP5, IL10, NFKBIA, GHRL, ARL6IP5, 
               
               
                 regulation of transport 
                   
                   
                   
                 201502_S_AT, 223862_AT, 
                 EGF 
               
               
                   
                   
                   
                   
                 200761_S_AT, 206254_AT 
                   
               
               
                 GO:0051050~positive 
                 0.000772048 
                 6.303676243 
                 0.017630829 
                 202381_AT, 207433_AT, 204088_AT, 
                 ADAM9, IL10, P2RX4, NFKBIA, NOD2, GHRL, 
               
               
                 regulation of transport 
                   
                   
                   
                 201502_S_AT, 220066_AT, 
                 PTX3 
               
               
                   
                   
                   
                   
                 223862_AT, 206157_AT 
                   
               
               
                 GO:0051384~response to 
                 0.000868651 
                 11.45233106 
                 0.019513971 
                 202381_AT, 203980_AT, 207433_AT, 
                 ADAM9, FABP4, IL10, CCL5, CCL2 
               
               
                 glucocorticoid stimulus 
                   
                   
                   
                 1555759_A_AT, 216598_S_AT 
                   
               
               
                 GO:0005625~soluble 
                 0.000768008 
                 4.517896389 
                 0.019903205 
                 215223_S_AT, 213503_X_AT, 
                 SOD2, ANXA2P1, FABP4, ANXA2P1, ANXA2P1, 
               
               
                 fraction 
                   
                   
                   
                 203980_AT, 210427_X_AT, 
                 TNFSF13B, EGF, SOD2, CCL5, SOD2, KYNU, 
               
               
                   
                   
                   
                   
                 201590_X_AT, 223502_S_AT, 
                 GPR34, CD55, KYNU, CD55 
               
               
                   
                   
                   
                   
                 206254_AT, 216841_S_AT, 
                   
               
               
                   
                   
                   
                   
                 1555759_A_AT, 221477_S_AT, 
                   
               
               
                   
                   
                   
                   
                 210663_S_AT, 244434_AT, 
                   
               
               
                   
                   
                   
                   
                 201926_S_AT, 217388_S_AT, 1555950_A_AT 
                   
               
               
                 GO:0031325~positive 
                 0.000976424 
                 2.701575533 
                 0.021581183 
                 213891_S_AT, 215223_S_AT, 
                 TCF4, SOD2, ADAM9, P2RX4, CD40, NFKBIA, 
               
               
                 regulation of cellular 
                   
                   
                   
                 202381_AT, 204088_AT, 
                 SRA1, CD40, TCF4, MITF, MAFB, EGF, PTX3, 
               
               
                 metabolic process 
                   
                   
                   
                 205153_S_AT, 201502_S_AT, 
                 HNRPLL, SOD2, ICAM1, IL10, SOD2, NOD2, 
               
               
                   
                   
                   
                   
                 224130_S_AT, 215346_AT, 
                 ICAM1 
               
               
                   
                   
                   
                   
                 212387_AT, 226066_AT, 218559_S_AT, 
                   
               
               
                   
                   
                   
                   
                 206254_AT, 206157_AT, 
                   
               
               
                   
                   
                   
                   
                 225386_S_AT, 216841_S_AT, 
                   
               
               
                   
                   
                   
                   
                 202637_S_AT, 207433_AT, 
                   
               
               
                   
                   
                   
                   
                 221477_S_AT, 220066_AT, 202638_S_AT 
                   
               
               
                 GO:0050817~coagulation 
                 0.001021169 
                 10.9751506 
                 0.022226472 
                 209555_S_AT, 203887_S_AT, 
                 CD36, THBD, CD40, PLAUR, CD40, CD9 
               
               
                   
                   
                   
                   
                 205153_S_AT, 214866_AT, 
                   
               
               
                   
                   
                   
                   
                 215346_AT, 201005_AT 
                   
               
               
                 GO:0007596~blood 
                 0.001021169 
                 10.9751506 
                 0.022226472 
                 209555_S_AT, 203887_S_AT, 
                 CD36, THBD, CD40, PLAUR, CD40, CD9 
               
               
                 coagulation 
                   
                   
                   
                 205153_S_AT, 214866_AT, 
                   
               
               
                   
                   
                   
                   
                 215346_AT, 201005_AT 
                   
               
               
                 GO:0031960~response to 
                 0.001104078 
                 10.75116794 
                 0.023661309 
                 202381_AT, 203980_AT, 207433_AT, 
                 ADAM9, FABP4, IL10, CCL5, CCL2 
               
               
                 corticosteroid stimulus 
                   
                   
                   
                 1555759_A_AT, 216598_S_AT 
                   
               
               
                 GO:0051047~positive 
                 0.0001104078 
                 10.75116794 
                 0.023661309 
                 202381_AT, 207433_AT, 204088_AT, 
                 ADAM9, IL10, P2RX4, NOD2, GHRL 
               
               
                 regulation of secretion 
                   
                   
                   
                 220066_AT, 223862_AT 
                   
               
               
                 GO:0030097~hemopoiesis 
                 0.001226255 
                 4.816523236 
                 0.025151654 
                 215223_S_AT, 216841_S_AT, 
                 SOD2, SOD2, MALT1, IL10, MMP9, MLF1, SOD2, 
               
               
                   
                   
                   
                   
                 210017_AT, 207433_AT, 
                 GPR183, VPS33A, IL7R 
               
               
                   
                   
                   
                   
                 203936_S_AT, 204784_S_AT, 
                   
               
               
                   
                   
                   
                   
                 221477_S_AT, 205419_AT, 
                   
               
               
                   
                   
                   
                   
                 204590_X_AT, 226218_AT 
                   
               
               
                 GO:0007275~multicellular 
                 0.001212038 
                 1.856892321 
                 0.025215437 
                 219358_S_AT, 213503_X_AT, 
                 ADAP2, ANXA2P1, MALT1, ANXA2P1, PLAUR, 
               
               
                 organismal development 
                   
                   
                   
                 210017_AT, 210427_X_AT, 
                 PRDM1, VPS33A, GHRL, IL7R, CCL2, MAFB, 
               
               
                   
                   
                   
                   
                 214866_AT, 228964_AT, 204590_X_AT, 
                 DAB2, TGM5, STATH, IL10, MMP9, SOD2, 
               
               
                   
                   
                   
                   
                 223862_AT, 226218_AT, 
                 GPR183, SOD2, CRYBB2, ADAM9, ANXA2P2, 
               
               
                   
                   
                   
                   
                 216598_S_AT, 218559_S_AT, 
                 ANXA2P1, CHST11, MITF, EGF, MXD1, SOD2, 
               
               
                   
                   
                   
                   
                 201278_AT, 207911_S_AT, 
                 THBD, MLF1, CD9 
               
               
                   
                   
                   
                   
                 206835_AT, 207433_AT, 203936_S_AT, 
                   
               
               
                   
                   
                   
                   
                 221477_S_AT, 205419_AT, 
                   
               
               
                   
                   
                   
                   
                 215223_S_AT, 206777_S_AT, 
                   
               
               
                   
                   
                   
                   
                 202381_AT, 208816_X_AT, 
                   
               
               
                   
                   
                   
                   
                 201590_X_AT, 219634_AT, 226066_AT, 
                   
               
               
                   
                   
                   
                   
                 206254_AT, 226275_AT, 
                   
               
               
                   
                   
                   
                   
                 216841_S_AT, 203887_S_AT, 
                   
               
               
                   
                   
                   
                   
                 204784_S_AT, 201005_AT 
                   
               
               
                 GO:0010033~response to 
                 0.001204931 
                 2.951937059 
                 0.025426793 
                 202381_AT, 201743_AT, 203980_AT, 
                 ADAM9, CD14, FABP4, MALT1, P2RX4, NFKBIA, 
               
               
                 organic substance 
                   
                   
                   
                 210017_AT, 204088_AT, 
                 GHRL, CCL2, THBD, IL10, CCL5, NOD2, KYNU, 
               
               
                   
                   
                   
                   
                 201502_S_AT, 223862_AT, 
                 KYNU 
               
               
                   
                   
                   
                   
                 216598_S_AT, 203887_S_AT, 
                   
               
               
                   
                   
                   
                   
                 207433_AT, 1555759_A_AT, 
                   
               
               
                   
                   
                   
                   
                 220066_AT, 210663_S_AT, 217388_S_AT 
                   
               
               
                 hsa04621: NOD-like 
                 0.000725707 
                 7.947169811 
                 0.026503364 
                 202644_S_AT, 201502_S_AT, 
                 TNFAIP3, NFKBIA, CCL5, NOD2, CD2, BIRC3 
               
               
                 receptor signaling pathway 
                   
                   
                   
                 1555759_A_AT, 220066_AT, 
                   
               
               
                   
                   
                   
                   
                 216598_S_AT, 210538_S_AT 
                   
               
               
                 GO:0002252~immune 
                 0.00136637 
                 7.18373434 
                 0.027603619 
                 202637_S_AT, 220066_AT, 
                 ICAM1, NOD2, CD55, IL7R, TNFSF13B, ICAM1, 
               
               
                 effector process 
                   
                   
                   
                 201926_S_AT, 226218_AT, 
                 CD55, PTX3 
               
               
                   
                   
                   
                   
                 223502_S_AT, 202638_S_AT, 
                   
               
               
                   
                   
                   
                   
                 1555950_A_AT, 206157_AT 
                   
               
               
                 GO:0032680~regulation of 
                 0.001395324 
                 17.56024096 
                 0.027800016 
                 201743_AT, 207433_AT, 
                 CD14, IL10, NOD2, GHRL 
               
               
                 tumor necrosis factor 
                   
                   
                   
                 220066_AT, 223862_AT 
                   
               
               
                 production 
                   
                   
                   
                   
                   
               
               
                 GO:0006954~inflammatory 
                 0.001443579 
                 4.682730924 
                 0.028365247 
                 201743_AT, 207433_AT, 205153_S_AT, 
                 CD14, IL10, CD40, CD40, TNFAIP6, CCL5, CD55, 
               
               
                 response 
                   
                   
                   
                 215346_AT, 206026_S_AT, 
                 CCL2, CD55, PTX3 
               
               
                   
                   
                   
                   
                 1555759_A_AT, 201926_S_AT, 
                   
               
               
                   
                   
                   
                   
                 216598_S_AT, 1555950_A_AT, 
                   
               
               
                   
                   
                   
                   
                 206157_AT 
                   
               
               
                 GO:0007599~hemostasis 
                 0.001483225 
                 9.939759036 
                 0.028750558 
                 209555_S_AT, 203887_S_AT, 
                 CD36, THBD, CD40, PLAUR, CD40, CC9 
               
               
                   
                   
                   
                   
                 205153_S_AT, 214866_AT, 
                   
               
               
                   
                   
                   
                   
                 215346_AT, 201005_AT 
                   
               
               
                 GO:0051173~positive 
                 0.001639177 
                 3.039272475 
                 0.03014551 
                 213891_S_AT, 215223_S_AT, 
                 TCF4, SOD2, CD40, P2RX4, SRA1, CD40, NFKBIA, 
               
               
                 regulation of nitrogen 
                   
                   
                   
                 205153_S_AT, 204088_AT, 
                 TCF4, MITF, PTX3, MAFB, HNRPLL, SOD2, IL10, 
               
               
                 compound metabolic 
                   
                   
                   
                 224130_S_AT, 215346_AT, 201502_S_AT, 
                 ICAM1, SOD2, ICAM1 
               
               
                 process 
                   
                   
                   
                 212387_AT, 226066_AT, 
                   
               
               
                   
                   
                   
                   
                 206157_AT, 218559_S_AT, 
                   
               
               
                   
                   
                   
                   
                 225386_S_AT, 216841_S_AT, 
                   
               
               
                   
                   
                   
                   
                 207433_AT, 202637_S_AT, 
                   
               
               
                   
                   
                   
                   
                 221477_S_AT, 202638_S_AT 
                   
               
               
                 GO:0051240~positive 
                 0.001622601 
                 5.463186078 
                 0.030221815 
                 210017_AT, 201743_AT, 
                 MALT1, CD14, CD40, CD40, CCL5, NOD2, GHRL, 
               
               
                 regulation of multicellular 
                   
                   
                   
                 205153_S_AT, 215346_AT, 
                 CCL2 
               
               
                 organismal process 
                   
                   
                   
                 1555759_A_AT, 220066_AT, 
                   
               
               
                   
                   
                   
                   
                 223862_AT, 216598_S_AT 
                   
               
               
                 GO:0042127~regulation of 
                 0.00158235 
                 2.859496441 
                 0.0302467 
                 215223_S_AT, 207536_S_AT, 
                 SOD2, TNFRSF9, FABP4, CD40, CD40, NFKBIA, 
               
               
                 cell proliferation 
                   
                   
                   
                 203980_AT, 205153_S_AT, 
                 GHRL, CHST11, CCL2, MITF, TNFSF13B, EGF, 
               
               
                   
                   
                   
                   
                 215346_AT, 201502_S_AT, 223862_AT, 
                 SOD2, IL10, SOD2, CD9 
               
               
                   
                   
                   
                   
                 219634_AT, 216598_S_AT, 
                   
               
               
                   
                   
                   
                   
                 226066_AT, 223502_S_AT, 206254_AT, 
                   
               
               
                   
                   
                   
                   
                 216841_S_AT, 207433_AT, 
                   
               
               
                   
                   
                   
                   
                 221477_S_AT, 201005_AT 
                   
               
               
                 GO:0005887~integral to 
                 0.001373673 
                 2.758590942 
                 0.030360284 
                 207536_S_AT, 209555_S_AT, 
                 TNFRSF9, CD36, P2RX4, FXYD2, CD40, CD40, 
               
               
                 plasma membrane 
                   
                   
                   
                 204088_AT, 207434_S_AT, 
                 IFNGR1, THBD, ICAM1, GPR183, CD9, CD55, 
               
               
                   
                   
                   
                   
                 205153_S_AT, 215346_AT, 
                 ITGB5, GPR34, CD55, STEAP1, ICAM1 
               
               
                   
                   
                   
                   
                 211676_S_AT, 203887_S_AT, 
                   
               
               
                   
                   
                   
                   
                 202637_S_AT, 205419_AT, 
                   
               
               
                   
                   
                   
                   
                 201005_AT, 201926_S_AT, 
                   
               
               
                   
                   
                   
                   
                 201125_S_AT, 244434_AT, 
                   
               
               
                   
                   
                   
                   
                 1555950_A_AT, 205542_AT, 202638_S_AT 
                   
               
               
                 GO:0050896~response to 
                 0.0016107 
                 1.733869102 
                 0.030387009 
                 209933_S_AT, 209555_S_AT, 
                 CD300A, CD36, MALT1, P2RX4, CD40, NFKBIA, 
               
               
                 stimulus 
                   
                   
                   
                 210017_AT, 204088_AT, 
                 PLAUR, CD40, GHRL, IL7R, CCL2, IL10, NOD2, 
               
               
                   
                   
                   
                   
                 205153_S_AT, 201502_S_AT, 214866_AT, 
                 SOD2, GPR183, CD55, KYNU, CD55, SOD2, 
               
               
                   
                   
                   
                   
                 215346_AT, 223862_AT, 
                 CRYBB2, ADAM9, FABP4, CD14, TNFAIP6, 
               
               
                   
                   
                   
                   
                 226218_AT, 216598_S_AT, 207433_AT, 
                 IFNGR1, TNFSF13B, PTX3, SOD2, THBD, IFIH1, 
               
               
                   
                   
                   
                   
                 220066_AT, 221477_S_AT, 
                 ICAM1, CCL5, KYNU, CD9, TREM1, ICAM1 
               
               
                   
                   
                   
                   
                 205419_AT, 201926_S_AT, 
                   
               
               
                   
                   
                   
                   
                 217388_S_AT, 1555950_A_AT, 
                   
               
               
                   
                   
                   
                   
                 215223_S_AT, 206777_S_AT, 202381_AT, 
                   
               
               
                   
                   
                   
                   
                 203980_AT, 201743_AT, 
                   
               
               
                   
                   
                   
                   
                 206026_S_AT, 211676_S_AT, 
                   
               
               
                   
                   
                   
                   
                 223502_S_AT, 206157_AT, 
                   
               
               
                   
                   
                   
                   
                 216841_S_AT, 203887_S_AT, 
                   
               
               
                   
                   
                   
                   
                 219209_AT, 202637_S_AT, 
                   
               
               
                   
                   
                   
                   
                 1555759_A_AT, 210663_S_AT, 
                   
               
               
                   
                   
                   
                   
                 201005_AT, 219434_AT, 202638_S_AT 
                   
               
               
                 GO:0002700~regulation of 
                 0.001768391 
                 16.2094532 
                 0.032085435 
                 210017_AT, 207433_AT, 205153_S_AT, 
                 MALT1, IL10, CD40, CD40, NOD2 
               
               
                 production of molecular 
                   
                   
                   
                 215346_AT, 220066_AT 
                   
               
               
                 mediator of immune 
                   
                   
                   
                   
                   
               
               
                 GO:0042113~B cell 
                 0.001821278 
                 9.407271945 
                 0.032628793 
                 210017_AT, 207433_AT, 205153_S_AT, 
                 MALT1, IL10, CD40, CD40, GPR183, IL7R 
               
               
                 activation 
                   
                   
                   
                 215346_AT, 205419_AT, 226218_AT 
                   
               
               
                 GO:0007165~signal 
                 0.001988349 
                 1.864144476 
                 0.034728937 
                 209555_S_AT, 210017_AT, 228708_AT, 
                 CD36, MALT1, RAB27B, P2RX4, PLAUR, NFKBIA, 
               
               
                 transduction 
                   
                   
                   
                 204088_AT, 214866_AT, 
                 GHRL, IL7R, CCL2, IL10, FGL2, NOD2, GPR183, 
               
               
                   
                   
                   
                   
                 201502_S_AT, 223862_AT, 226218_AT, 
                 ARHGAP18, LPAR6, ADAM9, ARHGAP18, 
               
               
                   
                   
                   
                   
                 216598_S_AT, 207433_AT, 
                 TNFAIP6, MTSS1, IFNGR1, TNFSF13B, EGF, LPXN, 
               
               
                   
                   
                   
                   
                 227265_AT, 220066_AT, 205419_AT, 
                 CCL5, GPR34, TREM1 
               
               
                   
                   
                   
                   
                 225166_AT, 218589_AT, 
                   
               
               
                   
                   
                   
                   
                 202381_AT, 225171_AT, 
                   
               
               
                   
                   
                   
                   
                 206026_S_AT, 203037_S_AT, 
                   
               
               
                   
                   
                   
                   
                 211676_S_AT, 223502_S_AT, 
                   
               
               
                   
                   
                   
                   
                 206254_AT, 216250_S_AT, 
                   
               
               
                   
                   
                   
                   
                 1555759_A_AT, 244434_AT, 219434_AT 
                   
               
               
                 GO:0048534~hemopoietic 
                 0.001967993 
                 4.436271401 
                 0.034791097 
                 215223_S_AT, 216841_S_AT, 
                 SOD2, SOD2, MALT1, IL10, MMP9, MLF1, SOD2, 
               
               
                 or lymphoid organ 
                   
                   
                   
                 210017_AT, 207433_AT, 
                 GPR183, VPS33A, IL7R 
               
               
                 development 
                   
                   
                   
                 203936_S_AT, 204784_S_AT, 
                   
               
               
                   
                   
                   
                   
                 221477_S_AT, 205419_AT, 
                   
               
               
                   
                   
                   
                   
                 204590_X_AT, 226218_AT 
                   
               
               
                 GO:0005102~receptor 
                 0.000373426 
                 3.379393637 
                 0.037380038 
                 202381_AT, 204088_AT, 211725_S_AT, 
                 ADAM9, P2RX4, BID, MTSS1, GHRL, CCL2, 
               
               
                 binding 
                   
                   
                   
                 203037_S_AT, 223862_AT, 
                 TNFSF13B, EGF, BID, ADAMDEC1, ICAM1, IL10, 
               
               
                   
                   
                   
                   
                 216598_S_AT, 223502_S_AT, 
                 FGL2, CCL5, BID, ICAM1 
               
               
                   
                   
                   
                   
                 206254_AT, 227143_S_AT, 
                   
               
               
                   
                   
                   
                   
                 206134_AT, 202637_S_AT, 
                   
               
               
                   
                   
                   
                   
                 207433_AT, 227265_AT, 
                   
               
               
                   
                   
                   
                   
                 1555759_A_AT, 204493_AT, 202638_S_AT 
                   
               
               
                 GO:0050794~regulation of 
                 0.002340559 
                 1.349482027 
                 0.040285453 
                 219358_S_AT, 213891_S_AT, 
                 ADAP2, TCF4, CD36, MALT1, P2RX4, NFE2L3, 
               
               
                 cellular process 
                   
                   
                   
                 209555_S_AT, 210017_AT, 
                 NFKBIA, DAB2, AGPAT9, MMP9, NOD2, SOD2, 
               
               
                   
                   
                   
                   
                 204088_AT, 236471_AT, 201502_S_AT, 
                 BIRC3, ARHGAP18, SOD2, LPAR6, ADAM9, 
               
               
                   
                   
                   
                   
                 201278_AT, 224480_S_AT, 
                 TNFRSF9, ARHGAP18, BID, NFE2L3, CHST11, 
               
               
                   
                   
                   
                   
                 203936_S_AT, 220066_AT, 
                 MITF, PTX3, TNFSF13B, EGF, MXD1, SOD2, 
               
               
                   
                   
                   
                   
                 221477_S_AT, 210538_S_AT, 
                 TNFAIP3, CD9, BID, GLRX3, NFKBIE, RAB27B, 
               
               
                   
                   
                   
                   
                 225166_AT, 215223_S_AT, 218589_AT, 
                 CD40, PLAUR, PRDM1, CD40, GHRL, IL7R, TCF4, 
               
               
                   
                   
                   
                   
                 202381_AT, 207536_S_AT, 
                 CCL2, MAFB, HNRPLL, BID, IL10, FGL2, GPR183, 
               
               
                   
                   
                   
                   
                 225171_AT, 211725_S_AT, 204702_S_AT, 
                 FABP4, SRA1, TNFAIP6, MTSS1, IFNGR1, CYTIP, 
               
               
                   
                   
                   
                   
                 219634_AT, 226066_AT, 
                 LPXN, ADAMDEC1, IFIH1, ICAM1, CCL5, GPR34, 
               
               
                   
                   
                   
                   
                 206157_AT, 223502_S_AT, 206254_AT, 
                 TREM1, ICAM1 
               
               
                   
                   
                   
                   
                 226275_AT, 216841_S_AT, 
                   
               
               
                   
                   
                   
                   
                 202644_S_AT, 201005_AT, 204493_AT, 
                   
               
               
                   
                   
                   
                   
                 209080_X_AT, 203927_AT, 
                   
               
               
                   
                   
                   
                   
                 228708_AT, 205153_S_AT, 214866_AT, 
                   
               
               
                   
                   
                   
                   
                 228964_AT, 215346_AT, 
                   
               
               
                   
                   
                   
                   
                 223862_AT, 226218_AT, 212387_AT, 
                   
               
               
                   
                   
                   
                   
                 216598_S_AT, 218559_S_AT, 
                   
               
               
                   
                   
                   
                   
                 225386_S_AT, 227143_S_AT, 207433_AT, 
                   
               
               
                   
                   
                   
                   
                 227265_AT, 205419_AT, 
                   
               
               
                   
                   
                   
                   
                 203980_AT, 224130_S_AT, 
                   
               
               
                   
                   
                   
                   
                 206026_S_AT, 203037_S_AT, 
                   
               
               
                   
                   
                   
                   
                 211676_S_AT, 209606_AT, 216250_S_AT, 
                   
               
               
                   
                   
                   
                   
                 206134_AT, 219209_AT, 
                   
               
               
                   
                   
                   
                   
                 202637_S_AT, 1555753_A_AT, 
                   
               
               
                   
                   
                   
                   
                 244434_AT, 219434_AT, 202638_S_AT 
                   
               
               
                 GO:0046651~lymphocyte 
                 0.002435526 
                 14.53261321 
                 0.041404807 
                 210017_AT, 207433_AT, 205153_S_AT, 
                 MALT1, IL10, CD40, CD40, IL7R 
               
               
                 proliferation 
                   
                   
                   
                 215346_AT, 226218_AT 
                   
               
               
                 GO:0070661~leukocyte 
                 0.002687978 
                 14.04819277 
                 0.045084782 
                 210017_AT, 207433_AT, 205153_S_AT, 
                 MALT1, IL10, CD40, CD40, IL7R 
               
               
                 proliferation 
                   
                   
                   
                 215346_AT, 226218_AT 
                   
               
               
                 GO:0032943~mononuclear 
                 0.002687978 
                 14.04819277 
                 0.045084782 
                 210017_AT, 207433_AT, 205153_S_AT, 
                 MALT1, IL10, CD40, CD40, IL7R 
               
               
                 cell proliferation 
                   
                   
                   
                 215346_AT, 226218_AT 
                   
               
               
                 GO:0002520~immune 
                 0.002858408 
                 4.152175203 
                 0.047340765 
                 215223_S_AT, 216841_S_AT, 
                 SOD2, SOD2, MALT1, IL10, MMP9, MLF1, SOD2, 
               
               
                 system development 
                   
                   
                   
                 210017_AT, 207433_AT, 
                 GPR183, VPS33A, IL7R 
               
               
                   
                   
                   
                   
                 203936_S_AT, 204784_S_AT, 
                   
               
               
                   
                   
                   
                   
                 221477_S_AT, 205419_AT, 
                   
               
               
                   
                   
                   
                   
                 204590_X_AT, 226218_AT 
                   
               
               
                 GO:0042994~cytoplasmic 
                 0.002996182 
                 35.12048193 
                 0.049019173 
                 203927_AT, 207433_AT, 201502_S_AT 
                 NFKBIE, IL10, NFKBIA 
               
               
                 sequestering of 
                   
                   
                   
                   
                   
               
               
                 transcription factor 
                   
                   
                   
                   
                   
               
               
                 GO:0042100~B cell 
                 0.002996182 
                 35.12048193 
                 0.049019173 
                 207433_AT, 205153_S_AT, 
                 IL10, CD40, CD40, IL7R 
               
               
                 proliferation 
                   
                   
                   
                 215346_AT, 226218_AT 
               
               
                   
               
             
          
           
               
                 Pathways significantly enriched among genes upregulated by Probioglat relative to GA (mannitol-corrected comparison) at 6 hours, earlier run including Kegg and GO BP only: 
               
             
          
           
               
                   
                   
                   
                 Fold 
                   
                   
                   
                   
               
               
                 Category 
                 Term 
                 Pathway 
                 Enrichment 
                 PValue 
                 Benjamini 
                 Probesets 
                 Genes 
               
               
                   
               
               
                 KEGG —   
                 hsa04060 
                 Cytokine-cytokine receptor 
                 4.35698707 
                 1.27E−04 
                 0.009767343 
                 204912_AT, 204533_AT, 207536_S_AT, 
                 IL10RA, CXCL10, TNFRSF9, IL10, CD40, CD40, 
               
               
                 PATHWAY 
                   
                 interaction 
                   
                   
                   
                 207433_AT, 205153_S_AT, 
                 CCL5, IFNGR1, IL7R, CCL22, TNFSF13B, EGF 
               
               
                   
                   
                   
                   
                   
                   
                 215346_AT, 1555759_A_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 211676_S_AT, 226218_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 216598_S_AT, 223502_S_AT, 206254_AT 
                   
               
               
                 KEGG —   
                 hsa04621 
                 NOD-like receptor signaling 
                 10.04279131 
                 2.62E−04 
                 0.010033132 
                 202644_S_AT, 201502_S_AT, 
                 TNFAIP3, NFKBIA, CCL5, NOD2, CCL2, BIRC3 
               
               
                 PATHWAY 
                   
                 pathway 
                   
                   
                   
                 1555759_A_AT, 220066_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 216598_S_AT, 210538_S_AT 
                   
               
               
                 GO_BP 
                 GO:0002237 
                 response to molecule of 
                 13.53138285 
                 1.85E−06 
                 0.002747953 
                 203887_S_AT, 210017_AT, 201743_AT, 
                 THBD, MALT1, CD14, IL10, NFKBIA, CCL5, NOD2, 
               
               
                   
                   
                 bacterial origin 
                   
                   
                   
                 207433_AT, 201502_S_AT, 
                 CCL2 
               
               
                   
                   
                   
                   
                   
                   
                 1555759_A_AT, 220066_AT, 216598_S_AT 
                   
               
               
                 GO_BP 
                 GO:0006955 
                 immune response 
                 3.794670407 
                 3.41E−06 
                 0.002530005 
                 209933_S_AT, 210017_AT, 201743_AT, 
                 CD300A, MALT1, CD14, EBI3, IL7R, CCL2, 
               
               
                   
                   
                   
                   
                   
                   
                 219424_AT, 226218_AT, 
                 TNFSF13B, PTX3, CXCL10, IFIH1, ICAM1, IL10, 
               
               
                   
                   
                   
                   
                   
                   
                 216598_S_AT, 223502_S_AT, 206157_AT, 
                 CCL5, KYNU, NOD2, GPR183, CD55, KYNU, 
               
               
                   
                   
                   
                   
                   
                   
                 204533_AT, 219209_AT, 
                 TREM1, CD55, ICAM1 
               
               
                   
                   
                   
                   
                   
                   
                 202637_S_AT, 207433_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 1555759_A_AT, 210663_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 220066_AT, 205419_AT, 201926_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 217388_S_AT, 219434_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 1555950_A_AT, 202638_S_AT 
                   
               
               
                 GO_BP 
                 GO:0042981 
                 regulation of apoptosis 
                 3.437543465 
                 6.44E−06 
                 0.003180733 
                 215223_S_AT, 202381_AT, 207536_S_AT, 
                 SOD2, ADAM9, TNFRSF9, MALT1, P2RX4, BID, 
               
               
                   
                   
                   
                   
                   
                   
                 210017_AT, 204088_AT, 
                 NFKBIA, GHRL, CHST11, CCL2, MITF, TNFSF13B, 
               
               
                   
                   
                   
                   
                   
                   
                 211725_S_AT, 201502_S_AT, 
                 BID, BTG1, SOD2, TNFAIP3, IFIH1, IL10, MMP9, 
               
               
                   
                   
                   
                   
                   
                   
                 223862_AT, 219634_AT, 
                 SOD2, NOD2, BID, BIRC3 
               
               
                   
                   
                   
                   
                   
                   
                 216598_S_AT, 226066_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 223502_S_AT, 227143_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 240347_AT, 216841_S_AT, 202644_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 219209_AT, 207433_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 203936_S_AT, 221477_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 220066_AT, 204493_AT, 210538_S_AT 
                   
               
               
                 GO_BP 
                 GO:0043067 
                 regulation of programmed 
                 3.403676042 
                 7.38E−06 
                 0.002735716 
                 215223_S_AT, 202381_AT, 207536_S_AT, 
                 SOD2, ADAM9, TNFRSF9, MALT1, P2RX4, BID, 
               
               
                   
                   
                 cell death 
                   
                   
                   
                 210017_AT, 204088_AT, 
                 NFKBIA, GHRL, CHST11, CCL2, MITF, TNFSF13B, 
               
               
                   
                   
                   
                   
                   
                   
                 211725_S_AT, 201502_S_AT, 
                 BID, BTG1, SOD2, TNFAIP3, IFIH1, IL10, MMP9, 
               
               
                   
                   
                   
                   
                   
                   
                 223862_AT, 219634_AT, 
                 SOD2, NOD2, BID, BIRC3 
               
               
                   
                   
                   
                   
                   
                   
                 216598_S_AT, 226066_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 223502_S_AT, 227143_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 240347_AT, 216841_S_AT, 202644_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 219209_AT, 207433_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 203936_S_AT, 221477_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 220066_AT, 204493_AT, 210538_S_AT 
                   
               
               
                 GO_BP 
                 GO:0010941 
                 regulation of cell death 
                 3.391147173 
                 7.77E−06 
                 0.00230315 
                 215223_S_AT, 202381_AT, 207536_S_AT, 
                 SOD2, ADAM9, TNFRSF9, MALT1, P2RX4, BID, 
               
               
                   
                   
                   
                   
                   
                   
                 210017_AT, 204088_AT, 
                 NFKBIA, GHRL, CHST11, CCL2, MITF, TNFSF13B, 
               
               
                   
                   
                   
                   
                   
                   
                 211725_S_AT, 201502_S_AT, 
                 BID, BTG1, SOD2, TNFAIP3, IFIH1, IL10, MMP9, 
               
               
                   
                   
                   
                   
                   
                   
                 223862_AT, 219634_AT, 
                 SOD2, NOD2, BID, BIRC3 
               
               
                   
                   
                   
                   
                   
                   
                 216598_S_AT, 226066_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 223502_S_AT, 227143_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 240347_AT, 216841_S_AT, 202644_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 219209_AT, 207433_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 203936_S_AT, 221477_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 220066_AT, 204493_AT, 210538_S_AT 
                   
               
               
                 GO_BP 
                 GO:0009611 
                 response to wounding 
                 4.116859404 
                 1.28E−05 
                 0.003159383 
                 215223_S_AT, 209555_S_AT, 
                 SOD2, CD36, CD14, CD40, CD40, TNFAIP6, 
               
               
                   
                   
                   
                   
                   
                   
                 201743_AT, 205153_S_AT, 
                 PLAUR, CCL2, PTX3, CXCL10, SOD2, THBD, IL10, 
               
               
                   
                   
                   
                   
                   
                   
                 215346_AT, 206026_S_AT, 214866_AT, 
                 MGLL, CCL5, SOD2, CD9, CD55, CD55 
               
               
                   
                   
                   
                   
                   
                   
                 216598_S_AT, 206157_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 204533_AT, 216841_S_AT, 203887_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 207433_AT, 239914_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 1555759_A_AT, 221477_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 201005_AT, 201926_S_AT, 1555950_A_AT 
                   
               
               
                 GO_BP 
                 GO:0032496 
                 response to 
                 13.22385142 
                 1.35E−05 
                 0.0028572 
                 203887_S_AT, 201743_AT, 
                 THBD, CD14, IL10, NFKBIA, CCL5, NOD2, CCL2 
               
               
                   
                   
                 lipopolysaccharide 
                   
                   
                   
                 207433_AT, 201502_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 1555759_A_AT, 220066_AT, 216598_S_AT 
                   
               
               
                 GO_BP 
                 GO:0045428 
                 regulation of nitric oxide 
                 26.93747511 
                 3.12E−05 
                 0.005768335 
                 215223_S_AT, 216841_S_AT, 
                 SOD2, SOD2, ICAM1, IL10, P2RX4, SOD2, ICAM1, 
               
               
                   
                   
                 biosynthetic process 
                   
                   
                   
                 202637_S_AT, 207433_AT, 
                 PTX3 
               
               
                   
                   
                   
                   
                   
                   
                 204088_AT, 221477_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 202638_S_AT, 206157_AT 
                   
               
               
                 GO_BP 
                 GO:0002684 
                 positive regulation of 
                 6.1118641 
                 3.39E−05 
                 0.005574201 
                 210017_AT, 205153_S_AT, 215346_AT, 
                 MALT1, CD40, CD40, EBI3, NFKBIA, IL7R, 
               
               
                   
                   
                 immune system process 
                   
                   
                   
                 219424_AT, 201502_S_AT, 
                 TNFSF13B, CHRNB2, ICAM1, NOD2, CD55, CD55, 
               
               
                   
                   
                   
                   
                   
                   
                 226218_AT, 223502_S_AT, 241389_AT, 
                 ICAM1 
               
               
                   
                   
                   
                   
                   
                   
                 202637_S_AT, 220066_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 201926_S_AT, 1555950_A_AT, 202638_S_AT 
                   
               
               
                 GO_BP 
                 GO:0002822 
                 regulation of adaptive 
                 15.8686217 
                 3.47E−05 
                 0.005133166 
                 210017_AT, 207433_AT, 205153_S_AT, 
                 MALT1, IL10, CD40, CD40, NOD2, IL7R, 
               
               
                   
                   
                 immune response based on 
                   
                   
                   
                 215346_AT, 220066_AT, 
                 TNFSF13B 
               
               
                   
                   
                 somatic recombination of 
                   
                   
                   
                 226218_AT, 223502_S_AT 
                   
               
               
                   
                   
                 immune receptors built 
                   
                   
                   
                   
                   
               
               
                   
                   
                 from immunoglobulin 
                   
                   
                   
                   
                   
               
               
                   
                   
                 superfamily domains 
                   
                   
                   
                   
                   
               
               
                 GO_BP 
                 GO:0002819 
                 regulation of adaptive 
                 15.58525346 
                 3.79E−05 
                 0.005096778 
                 210017_AT, 207433_AT, 205153_S_AT, 
                 MALT1, IL10, CD40, CD40, NOD2, IL7R, 
               
               
                   
                   
                 immune response 
                   
                   
                   
                 215346_AT, 220066_AT, 
                 TNFSF13B 
               
               
                   
                   
                   
                   
                   
                   
                 226218_AT, 223502_S_AT 
                   
               
               
                 GO_BP 
                 GO:0060341 
                 regulation of cellular 
                 5.865417967 
                 4.67E−05 
                 0.005763766 
                 203927_AT, 202381_AT, 241389_AT, 
                 NFKBIE, ADAM9, CHRNB2, IL10, RAB27B, CD40, 
               
               
                   
                   
                 localization 
                   
                   
                   
                 207433_AT, 228708_AT, 
                 NFKBIA, CD40, NOD2, GHRL, EGF 
               
               
                   
                   
                   
                   
                   
                   
                 205153_S_AT, 201502_S_AT, 215346_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 220066_AT, 223862_AT, 206254_AT 
                   
               
               
                 GO_BP 
                 GO:0050878 
                 regulation of body fluid 
                 8.253183863 
                 4.82E−05 
                 0.005486427 
                 206835_AT, 213503_X_AT, 
                 STATH, ANXA2P1, CD36, THBD, ANXA2P2, 
               
               
                   
                   
                 levels 
                   
                   
                   
                 209555_S_AT, 203887_S_AT, 
                 ANXA2P1, CD40, PLAUR, ANXA2P1, CD40, CD9 
               
               
                   
                   
                   
                   
                   
                   
                 208816_X_AT, 210427_X_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 205153_S_AT, 214866_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 201590_X_AT, 215346_AT, 2011305_AT 
                   
               
               
                 GO_BP 
                 GO:0006952 
                 defense response 
                 3.547862575 
                 6.58E−05 
                 0.006947618 
                 210017_AT, 201743_AT, 205153_S_AT, 
                 MALT1, CD14, CD40, CD40, TNFAIP6, CCL2, 
               
               
                   
                   
                   
                   
                   
                   
                 215346_AT, 206026_S_AT, 
                 PTX3, CXCL10, TPSAB1, IFIH1, IL10, MGLL, CCL5, 
               
               
                   
                   
                   
                   
                   
                   
                 216598_S_AT, 206157_AT, 204533_AT, 
                 NOD2, KYNU, CD55, KYNU, CD55 
               
               
                   
                   
                   
                   
                   
                   
                 207741_X_AT, 219209_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 207433_AT, 239914_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 1555759_A_AT, 220066_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 210663_S_AT, 201926_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 217388_S_AT, 1555950_A_AT 
                   
               
               
                 GO_BP 
                 GO:0051046 
                 regulation of secretion 
                 6.480396487 
                 6.85E−05 
                 0.006751625 
                 202381_AT, 241389_AT, 207433_AT, 
                 ADAM9, CHRNB2, IL10, RAB27B, P2RX4, CD40, 
               
               
                   
                   
                   
                   
                   
                   
                 228708_AT, 204088_AT, 
                 CD40, NOD2, GHRL, EGF 
               
               
                   
                   
                   
                   
                   
                   
                 205153_S_AT, 215346_AT, 220066_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 223862_AT, 206254_AT 
                   
               
               
                 GO_BP 
                 GO:0042127 
                 regulation of cell 
                 3.142134962 
                 7.26E−05 
                 0.006714161 
                 215223_S_AT, 207536_S_AT, 
                 SOD2, TNFRSF9, FABP4, CD40, NFKBIA, EBI3, 
               
               
                   
                   
                 proliferation 
                   
                   
                   
                 203980_AT, 205153_S_AT, 
                 CD40, GHRL, CHST11, CCL2, MITF, TNFSF13B, 
               
               
                   
                   
                   
                   
                   
                   
                 201502_S_AT, 219424_AT, 215346_AT, 
                 EGF, BTG1, CXCL10, SOD2, CHRNB2, IL10, SOD2, 
               
               
                   
                   
                   
                   
                   
                   
                 223862_AT, 219634_AT, 
                 CD9 
               
               
                   
                   
                   
                   
                   
                   
                 216598_S_AT, 226066_AT, 223502_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 206254_AT, 240347_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 204533_AT, 216841_S_AT, 241389_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 207433_AT, 221477_S_AT, 201005_AT 
                   
               
               
                 GO_BP 
                 GO:0006916 
                 anti-apoptosis 
                 6.355151895 
                 7.86E−05 
                 0.006835343 
                 215223_S_AT, 216841_S_AT, 
                 SOD2, SOD2, TNFAIP3, MALT1, IL10, NFKBIA, 
               
               
                   
                   
                   
                   
                   
                   
                 202644_S_AT, 210017_AT, 
                 SOD2, GHRL, CCL2, TNFSF13B, BIRC3 
               
               
                   
                   
                   
                   
                   
                   
                 207433_AT, 201502_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 221477_S_AT, 223862_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 216598_S_AT, 223502_S_AT, 210538_S_AT 
                   
               
               
                 GO_BP 
                 GO:0051223 
                 regulation of protein 
                 8.931899642 
                 1.24E−04 
                 0.010183221 
                 203927_AT, 202381_AT, 207433_AT, 
                 NFKBIE, ADAM9, IL10, CD40, NFKBIA, CD40, 
               
               
                   
                   
                 transport 
                   
                   
                   
                 205153_S_AT, 201502_S_AT, 
                 NOD2, EGF 
               
               
                   
                   
                   
                   
                   
                   
                 215346_AT, 220066_AT, 206254_AT 
                   
               
               
                 GO_BP 
                 GO:0043066 
                 negative regulation of 
                 4.52001701 
                 1.42E−04 
                 0.011048668 
                 215223_S_AT, 210017_AT, 201502_S_AT, 
                 SOD2, MALT1, NFKBIA, GHRL, CHST11, CCL2, 
               
               
                   
                   
                 apoptosis 
                   
                   
                   
                 223862_AT, 219634_AT, 
                 MITF, TNFSF13B, SOD2, TNFAIP3, IL10, SOD2, 
               
               
                   
                   
                   
                   
                   
                   
                 216598_S_AT, 226066_AT, 
                 BIRC3 
               
               
                   
                   
                   
                   
                   
                   
                 223502_S_AT, 216841_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 202644_S_AT, 207433_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 221477_S_AT, 210538_S_AT 
                   
               
               
                 GO_BP 
                 GO:0001775 
                 cell activation 
                 5.068375108 
                 1.43E−04 
                 0.010557063 
                 202381_AT, 210017_AT, 241389_AT, 
                 ADAM9, MALT1, CHRNB2, ICAM1, IL10, P2RX4, 
               
               
                   
                   
                   
                   
                   
                   
                 202637_S_AT, 207433_AT, 
                 CD40, CD40, GPR183, CD9, IL7R, ICAM1 
               
               
                   
                   
                   
                   
                   
                   
                 204088_AT, 205153_S_AT, 215346_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 205419_AT, 201005_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 226218_AT, 202638_S_AT 
                   
               
               
                 GO_BP 
                 GO:0043069 
                 negative regulation of 
                 4.457064127 
                 1.59E−04 
                 0.011205923 
                 215223_S_AT, 210017_AT, 201502_S_AT, 
                 SOD2, MALT1, NFKBIA, GHRL, CHST11, CCL2, 
               
               
                   
                   
                 programmed cell death 
                   
                   
                   
                 223862_AT, 219634_AT, 
                 MITF, TNFSF13B, SOD2, TNFAIP3, IL10, SOD2, 
               
               
                   
                   
                   
                   
                   
                   
                 216598_S_AT, 226066_AT, 
                 BIRC3 
               
               
                   
                   
                   
                   
                   
                   
                 223502_S_AT, 216841_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 202644_S_AT, 207433_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 221477_S_AT, 210538_S_AT 
                   
               
               
                 GO_BP 
                 GO:0060548 
                 negative regulation of cell 
                 4.444683393 
                 1.63E−04 
                 0.010942714 
                 215223_S_AT, 210017_AT, 201502_S_AT, 
                 SOD2, MALT1, NFKBIA, GHRL, CHST11, CCL2, 
               
               
                   
                   
                 death 
                   
                   
                   
                 223862_AT, 219634_AT, 
                 MITF, TNFSF13B, SOD2, TNFAIP3, IL10, SOD2, 
               
               
                   
                   
                   
                   
                   
                   
                 216598_S_AT, 226066_AT, 
                 BIRC3 
               
               
                   
                   
                   
                   
                   
                   
                 223502_S_AT, 216841_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 202644_S_AT, 207433_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 221477_S_AT, 210538_S_AT 
                   
               
               
                 GO_BP 
                 GO:0042113 
                 B cell activation 
                 11.48387097 
                 1.65E−04 
                 0.010566072 
                 210017_AT, 241389_AT, 207433_AT, 
                 MALT1, CHRNB2, IL10, CD40, CD40, GPR183, 
               
               
                   
                   
                   
                   
                   
                   
                 205153_S_AT, 215346_AT, 
                 IL7R 
               
               
                   
                   
                   
                   
                   
                   
                 205419_AT, 226218_AT 
                   
               
               
                 GO_BP 
                 GO:0070201 
                 regulation of establishment 
                 8.415178175 
                 1.72E−04 
                 0.01059381 
                 203927_AT, 202381_AT, 207433_AT, 
                 NFKBIE, ADAM9, IL10, CD40, NFKBIA, CD40, 
               
               
                   
                   
                 of protein localization 
                   
                   
                   
                 205153_S_AT, 201502_S_AT, 
                 NOD2, EGF 
               
               
                   
                   
                   
                   
                   
                   
                 215346_AT, 220066_AT, 206254_AT 
                   
               
               
                 GO_BP 
                 GO:0046903 
                 secretion 
                 4.84874552 
                 1.99E−04 
                 0.011766402 
                 201278_AT, 204533_AT, 206835_AT, 
                 DAB2, CXCL10, STATH, ANXA2P1, CHRNB2, 
               
               
                   
                   
                   
                   
                   
                   
                 213503_X_AT, 241389_AT, 
                 ANXA2P2, ANXA2P1, ANXA2P1, CCL5, VPS33A, 
               
               
                   
                   
                   
                   
                   
                   
                 208816_X_AT, 210427_X_AT, 
                 GHRL, TNFSF13B 
               
               
                   
                   
                   
                   
                   
                   
                 201590_X_AT, 1555759_A_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 204590_X_AT, 223862_AT, 223502_S_AT 
                   
               
               
                 GO_BP 
                 GO:0009617 
                 response to bacterium 
                 6.029528107 
                 3.40E−04 
                 0.019214892 
                 203887_S_AT, 210017_AT, 201743_AT, 
                 THBD, MALT1, CD14, IL10, NFKBIA, CCL5, NOD2, 
               
               
                   
                   
                   
                   
                   
                   
                 207433_AT, 201502_S_AT, 
                 CCL2 
               
               
                   
                   
                   
                   
                   
                   
                 1555759_A_AT, 220066_AT, 216598_S_AT 
                   
               
               
                 GO_BP 
                 GO:0010033 
                 response to organic 
                 3.026262807 
                 3.46E−04 
                 0.018159624 
                 202381_AT, 210017_AT, 201743_AT, 
                 ADAM9, MALT1, CD14, FABP4, P2RX4, NFKBIA, 
               
               
                   
                   
                 substance 
                   
                   
                   
                 203980_AT, 204088_AT, 
                 GHRL, HMGB2, CCL2, THBD, CHRNB2, IL10, 
               
               
                   
                   
                   
                   
                   
                   
                 201502_S_AT, 223862_AT, 
                 CCL5, NOD2, KYNU, KYNU 
               
               
                   
                   
                   
                   
                   
                   
                 243368_AT, 216598_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 203887_S_AT, 241389_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 207433_AT, 1555759_A_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 220066_AT, 210663_S_AT, 217388_S_AT 
                   
               
               
                 GO_BP 
                 GO:0032880 
                 regulation of protein 
                 7.378525791 
                 3.51E−04 
                 0.018439313 
                 203927_AT, 202381_AT, 207433_AT, 
                 NFKBIE, ADAM9, IL10, CD40, NFKBIA, CD40, 
               
               
                   
                   
                 localization 
                   
                   
                   
                 205153_S_AT, 201502_S_AT, 
                 NOD2, EGF 
               
               
                   
                   
                   
                   
                   
                   
                 215346_AT, 220066_AT, 2006254_AT 
                   
               
               
                 GO_BP 
                 GO:0006954 
                 inflammatory response 
                 4.475765095 
                 3.60E−04 
                 0.018262369 
                 204533_AT, 201743_AT, 207433_AT, 
                 CXCL10, CD14, IL10, MGLL, CD40, CD40, 
               
               
                   
                   
                   
                   
                   
                   
                 239914_AT, 205153_S_AT, 
                 TNFAIP6, CCL5, CD55, CCL2, CD55, PTX3 
               
               
                   
                   
                   
                   
                   
                   
                 215346_AT, 206026_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 1555759_A_AT, 201926_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 216598_S_AT, 1555950_A_AT, 206157_AT 
                   
               
               
                 GO_BP 
                 GO:0045429 
                 positive regulation of nitric 
                 27.70711726 
                 3.70E−04 
                 0.018161517 
                 215223_S_AT, 216841_S_AT, 
                 SOD2, SOD2, ICAM1, P2RX4, SOD2, ICAM1, 
               
               
                   
                   
                 oxide biosynthetic process 
                   
                   
                   
                 202637_S_AT, 204088_AT, 
                 PTX3 
               
               
                   
                   
                   
                   
                   
                   
                 221477_S_AT, 202638_S_AT, 206157_AT 
                   
               
               
                 GO_BP 
                 GO:0002706 
                 regulation of lymphocyte 
                 13.46873755 
                 4.89E−04 
                 0.023119461 
                 210017_AT, 207433_AT, 205153_S_AT, 
                 MALT1, IL10, CD40, CD40, NOD2, IL7R 
               
               
                   
                   
                 mediated immunity 
                   
                   
                   
                 215346_AT, 220066_AT, 226218_AT 
                   
               
               
                 GO_BP 
                 G0:0051249 
                 regulation of lymphocyte 
                 6.879976751 
                 5.10E−04 
                 0.023373393 
                 210017_AT, 241389_AT, 207433_AT, 
                 MALT1, CHRNB2, IL10, CD40, EBI3, CD40, IL7R, 
               
               
                   
                   
                 activation 
                   
                   
                   
                 205153_S_AT, 219424_AT, 
                 TNFSF13B 
               
               
                   
                   
                   
                   
                   
                   
                 215346_AT, 226218_AT, 223502_S_AT 
                   
               
               
                 GO_BP 
                 GO:0051251 
                 positive regulation of 
                 8.997672098 
                 5.13E−04 
                 0.022828997 
                 210017_AT, 241389_AT, 205153_S_AT, 
                 MALT1, CHRNB2, CD40, EBI3, CD40, IL7R, 
               
               
                   
                   
                 lymphocyte activation 
                   
                   
                   
                 219424_AT, 215346_AT, 
                 TNFSF13B 
               
               
                   
                   
                   
                   
                   
                   
                 226218_AT, 223502_S_AT 
                   
               
               
                 GO_BP 
                 GO:0002697 
                 regulation of immune 
                 8.641328649 
                 6.18E−04 
                 0.026609275 
                 210017_AT, 202637_S_AT, 207433_AT, 
                 MALT1, ICAM1, IL10, CD40, CD40, NOD2, IL7R, 
               
               
                   
                   
                 effector process 
                   
                   
                   
                 205153_S_AT, 215346_AT, 
                 ICAM1 
               
               
                   
                   
                   
                   
                   
                   
                 220066_AT, 226218_AT, 202638_S_AT 
                   
               
               
                 GO_BP 
                 GO:0050708 
                 regulation of protein 
                 12.5398591 
                 6.42E−04 
                 0.026859383 
                 202381_AT, 207433_AT, 205153_S_AT, 
                 ADAM9, IL10, CD40, CD40, NOD2, EGF 
               
               
                   
                   
                 secretion 
                   
                   
                   
                 215346_AT, 220066_AT, 206254_AT 
                   
               
               
                 GO_BP 
                 GO:0032101 
                 regulation of response to 
                 6.404003517 
                 7.44E−04 
                 0.030210271 
                 213503_X_AT, 203980_AT, 
                 ANXA2P1, FABP4, ANXA2P2, IL10, ANXA2P1, 
               
               
                   
                   
                 external stimulus 
                   
                   
                   
                 208816_X_AT, 207433_AT, 
                 ANXA2P1, CCL5, GHRL, NTSE 
               
               
                   
                   
                   
                   
                   
                   
                 210427_X_AT, 201590_X_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 1555759_A_AT, 223862_AT, 203939_AT 
                   
               
               
                 GO_BP 
                 GO:0002696 
                 positive regulation of 
                 8.233718807 
                 7.70E−04 
                 0.030405582 
                 210017_AT, 241389_AT, 205153_S_AT, 
                 MALT1, CHRNB2, CD40, EBI3, CD40, IL7R, 
               
               
                   
                   
                 leukocyte activation 
                   
                   
                   
                 219424_AT, 215346_AT, 
                 TNFSF13B 
               
               
                   
                   
                   
                   
                   
                   
                 226218_AT, 223502_S_AT 
                   
               
               
                 GO_BP 
                 GO:0002703 
                 regulation of leukocyte 
                 11.922314472 
                 7.77E−04 
                 0.029915725 
                 210017_AT, 207433_AT, 205153_S_AT, 
                 MALT1, IL10, CD40, CD40, NOD2, IL7R 
               
               
                   
                   
                 mediated immunity 
                   
                   
                   
                 215346_AT, 220066_AT, 226218_AT 
                   
               
               
                 GO_BP 
                 GO:0051050 
                 positive regulation of 
                 5.218380828 
                 8.05E−04 
                 0.030169382 
                 202381_AT, 241389_AT, 207433_AT, 
                 ADAM9, CHRNB2, IL10, P2RX4, NFKBIA, NOD2, 
               
               
                   
                   
                 transport 
                   
                   
                   
                 204088_AT, 201502_S_AT, 
                 GHRL, PTX3 
               
               
                   
                   
                   
                   
                   
                   
                 220066_AT, 223862_AT, 206157_AT 
                   
               
               
                 GO_BP 
                 GO:0007155 
                 cell adhesion 
                 2.909247312 
                 8.70E−04 
                 0.031759691 
                 209933_S_AT, 213428_S_AT, 
                 CD300A, COL6A1, ADAM9, CD36, ATP2C1, 
               
               
                   
                   
                   
                   
                   
                   
                 202381_AT, 209555_S_AT, 
                 TNFAIP6, MTSS1, ICAM2, CCL2, LPXN, ICAM1, 
               
               
                   
                   
                   
                   
                   
                   
                 237278_X_AT, 206026_S_AT, 
                 CCL5, CD9, ITGB5, ICAM1 
               
               
                   
                   
                   
                   
                   
                   
                 203037_S_AT, 213620_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 216598_S_AT, 216250_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 202637_S_AT, 1555759_A_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 201005_AT, 201125_S_AT, 202638_S_AT 
                   
               
               
                 GO_BP 
                 GO:0051047 
                 positive regulation of 
                 8.007102693 
                 8.73E−04 
                 0.031121915 
                 202381_AT, 241389_AT, 207433_AT, 
                 ADAM9, CHRNB2, IL10, P2RX4, NOD2, GHRL 
               
               
                   
                   
                 secretion 
                   
                   
                   
                 204088_AT, 220066_AT, 223862_AT 
                   
               
               
                 GO_BP 
                 GO:0051241 
                 negative regulation of 
                 6.208759507 
                 8.74E−04 
                 0.030436041 
                 206835_AT, 213503_X_AT, 208816_X_AT, 
                 STATH, ANXA2P1, ANXA2P2, IL10, P2RX4, 
               
               
                   
                   
                 multicellular organismal 
                   
                   
                   
                 207433_AT, 204088_AT, 
                 ANXA2P1, ANXA2P1, NOD2, GHRL 
               
               
                   
                   
                 process 
                   
                   
                   
                 210427_X_AT, 201590_X_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 220066_AT, 223862_AT 
                   
               
               
                 GO_BP 
                 GO:0022610 
                 biological adhesion 
                 2.905097173 
                 8.81E−04 
                 0.029962986 
                 209933_S_AT, 213428_S_AT, 
                 CD300A, COL6A1, ADAM9, CD36, ATP2C1, 
               
               
                   
                   
                   
                   
                   
                   
                 202381_AT, 209555_S_AT, 
                 TNFAIP6, MTSS1, ICAM2, CCL2, LPXN, ICAM1, 
               
               
                   
                   
                   
                   
                   
                   
                 237278_X_AT, 206026_S_AT, 
                 CCL5, CD9, ITGB5, ICAM1 
               
               
                   
                   
                   
                   
                   
                   
                 203037_S_AT, 213620_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 216598_S_AT, 216250_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 202637_S_AT, 1555759_A_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 201005_AT, 201125_S_AT, 202638_S_AT 
                   
               
               
                 GO_BP 
                 GO:0030888 
                 regulation of B cell 
                 20.78033794 
                 8.82E−04 
                 0.029309007 
                 241389_AT, 207433_AT, 205153_S_AT, 
                 CHRNB2, IL10, CD40, CD40, TNFSF13B 
               
               
                   
                   
                 proliferation 
                   
                   
                   
                 215346_AT, 223502_S_AT 
                   
               
               
                 GO_BP 
                 GO:0002694 
                 regulation of leukocyte 
                 6.133955176 
                 9.31E−04 
                 0.030258714 
                 210017_AT, 241389_AT, 207433_AT, 
                 MALT1, CHRNB2, IL10, CD40, EBI3, CD40, IL7R, 
               
               
                   
                   
                 activation 
                   
                   
                   
                 205153_S_AT, 219424_AT, 
                 TNFSF13B 
               
               
                   
                   
                   
                   
                   
                   
                 215346_AT, 226218_AT, 223502_S_AT 
                   
               
               
                 GO_BP 
                 GO:0050867 
                 positive regulation of cell 
                 7.862830573 
                 9.48E−04 
                 0.030125327 
                 210017_AT, 241389_AT, 205153_S_AT, 
                 MALT1, CHRNB2, CD40, EBI3, CD40, IL7R, 
               
               
                   
                   
                 activation 
                   
                   
                   
                 219424_AT, 215346_AT, 
                 TNFSF13B 
               
               
                   
                   
                   
                   
                   
                   
                 226218_AT, 223502_S_AT 
                   
               
               
                 GO_BP 
                 GO:0048584 
                 positive regulation of 
                 4.930927647 
                 0.001120224 
                 0.034771388 
                 210017_AT, 203980_AT, 
                 MALT1, FABP4, NFKBIA, CCL5, NOD2, GHRL, 
               
               
                   
                   
                 response to stimulus 
                   
                   
                   
                 201502_S_AT, 1555759_A_AT, 
                 CD5S, TNFSF13B, CD55 
               
               
                   
                   
                   
                   
                   
                   
                 220066_AT, 223862_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 201926_S_AT, 223502_S_AT, 1555950_A_AT 
                   
               
               
                 GO_BP 
                 GO:0030097 
                 hemopoiesis 
                 4.930927647 
                 0.001120224 
                 0.034771388 
                 215223_S_AT, 216841_S_AT, 
                 SOD2, SOD2, MALT1, IL10, MMP9, MLf1, SOD2, 
               
               
                   
                   
                   
                   
                   
                   
                 210017_AT, 207433_AT, 
                 GPR183, VPS33A, IL7R 
               
               
                   
                   
                   
                   
                   
                   
                 203936_S_AT, 204784_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 221477_S_AT, 205419_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 204590_X_AT, 226218_AT 
                   
               
               
                 GO_BP 
                 GO:0032680 
                 regulation of tumor 
                 18.7693375 
                 0.00119195 
                 0.03620158 
                 201743_AT, 207433_AT, 
                 CD14, IL10, NOD2, GHRL 
               
               
                   
                   
                 necrosis factor production 
                   
                   
                   
                 220066_AT, 223862_AT 
                   
               
               
                 GO_BP 
                 GO:0050865 
                 regulation of cell activation 
                 5.818494624 
                 0.001223425 
                 0.036396133 
                 210017_AT, 241389_AT, 207433_AT, 
                 MALT1, CHRNB2, IL10, CD40, EBI3, CD40, IL7R, 
               
               
                   
                   
                   
                   
                   
                   
                 205153_S_AT, 219424_AT, 
                 TNFSF13B 
               
               
                   
                   
                   
                   
                   
                   
                 215346_AT, 226218_AT, 223502_S_AT 
                   
               
               
                 GO_BP 
                 GO:0045321 
                 leukocyte activation 
                 4.808673243 
                 0.00129524 
                 0.037737147 
                 202381_AT, 210017_AT, 241389_AT, 
                 ADAM9, MALT1, CHRNB2, ICAM1, IL10, CD40, 
               
               
                   
                   
                   
                   
                   
                   
                 202637_S_AT, 207433_AT, 
                 CD40, GPR183, IL7R, ICAM1 
               
               
                   
                   
                   
                   
                   
                   
                 205153_S_AT, 215346_AT, 205419_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 226218_AT, 202638_S_AT 
                   
               
               
                 GO_BP 
                 GO:0051173 
                 positive regulation of 
                 2.9363521 
                 0.001352769 
                 0.038623899 
                 213891_S_AT, 215223_S_AT, 
                 TCF4, SOD2, CD40, P2RX4, SRA1, CD40, NFKBIA, 
               
               
                   
                   
                 nitrogen compound 
                   
                   
                   
                 205153_S_AT, 204088_AT, 
                 HMGB2, TCF4, MITF, MAFB, PTX3, HNRPLL, 
               
               
                   
                   
                 metabolic process 
                   
                   
                   
                 224130_S_AT, 215346_AT, 201502_S_AT, 
                 SOD2, ICAM1, IL10, SOD2, ICAM1 
               
               
                   
                   
                   
                   
                   
                   
                 243368_AT, 212387_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 226066_AT, 218559_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 206157_AT, 225386_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 216841_S_AT, 202637_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 207433_AT, 221477_S_AT, 202638_S_AT 
                   
               
               
                 GO_BP 
                 GO:0051240 
                 positive regulation of 
                 4.769257888 
                 0.001358112 
                 0.03804226 
                 210017_AT, 241389_AT, 201743_AT, 
                 MALT1, CHRNB2, CD14, CD40, CD40, CCL5, 
               
               
                   
                   
                 multicellular organismal 
                   
                   
                   
                 205153_S_AT, 215346_AT, 
                 NOD2, GHRL, CCL2 
               
               
                   
                   
                 process 
                   
                   
                   
                 1555759_A_AT, 220066_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 223862_AT, 216598_S_AT 
                   
               
               
                 GO_BP 
                 GO:0001817 
                 regulation of cytokine 
                 5.625616349 
                 0.001454089 
                 0.039925244 
                 210017_AT, 201743_AT, 207433_AT, 
                 MALT1, CD14, IL10, CD40, EBI3, CD40, NOD2, 
               
               
                   
                   
                 production 
                   
                   
                   
                 205153_S_AT, 219424_AT, 
                 GHRL 
               
               
                   
                   
                   
                   
                   
                   
                 215346_AT, 220066_AT, 223862_AT 
                   
               
               
                 GO_BP 
                 GO:0050727 
                 regulation of inflammatory 
                 9.569892473 
                 0.001768848 
                 0.047488977 
                 203980_AT, 207433_AT, 1555759_A_AT, 
                 FABP4, IL10, CCL5, GHRL, NT5E 
               
               
                   
                   
                 response 
                   
                   
                   
                 223862_AT, 203939_AT 
                   
               
               
                 GO_BP 
                 GO:0010647 
                 positive regulation of cell 
                 3.979213648 
                 0.001776941 
                 0.046854541 
                 210017_AT, 241389_AT, 204088_AT, 
                 MALT1, CHRNB2, P2RX4, ATP2C1, CD40, CD40, 
               
               
                   
                   
                 communication 
                   
                   
                   
                 237278_X_AT, 205153_S_AT, 
                 NOD2, GHRL, CCL2, EGF 
               
               
                   
                   
                   
                   
                   
                   
                 215346_AT, 220066_AT, 223862_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 216598_S_AT, 206254_AT 
                   
               
               
                 GO_BP 
                 GO:0002250 
                 adaptive immune response 
                 9.445608155 
                 0.001856176 
                 0.048042002 
                 202637_S_AT, 207433_AT, 219424_AT, 
                 ICAM1, IL10, EBI3, NOD2, CD55, ICAM1, CD55 
               
               
                   
                   
                   
                   
                   
                   
                 220066_AT, 201926_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 202638_S_AT, 1555950_A_AT 
                   
               
               
                 GO_BP 
                 GO:0002460 
                 adaptive immune response 
                 9.445608155 
                 0.001856176 
                 0.048042002 
                 202637_S_AT, 207433_AT, 219424_AT, 
                 ICAM1, IL10, EBI3, NOD2, CD55, ICAM1, CD55 
               
               
                   
                   
                 based on somatic 
                   
                   
                   
                 220066_AT, 201926_S_AT, 
                   
               
               
                   
                   
                 recombination of immune 
                   
                   
                   
                 202638_S_AT, 1555950_A_AT 
                   
               
               
                   
                   
                 receptors built from 
                   
                   
                   
                   
                   
               
               
                   
                   
                 immunoglobulin 
                   
                   
                   
                   
                   
               
               
                   
                   
                 superfamily domains 
                   
                   
                   
                   
                   
               
               
                 GO_BP 
                 GO:0051384 
                 response to glucocorticoid 
                 9.324510615 
                 0.00194645 
                 0.043450316 
                 202381_AT, 203980_AT, 
                 ADAM9, FABP4, IL10, CCL5, CCL2 
               
               
                   
                   
                 stimulus 
                   
                   
                   
                 207433_AT, 1555759_A_AT, 216598_S_AT 
                   
               
               
                 GO_BP 
                 GO:0048534 
                 hemopoietic or lymphoid 
                 4.475765095 
                 0.001951531 
                 0.048752558 
                 215223_S_AT, 216841_S_AT, 
                 SOD2, SOD2, MALT1, IL10, MMP9, MLF1, SOD2, 
               
               
                   
                   
                 organ development 
                   
                   
                   
                 210017_AT, 207433_AT, 
                 GPR183, VPS33A, IL7R 
               
               
                   
                   
                   
                   
                   
                   
                 203936_S_AT, 204784_S_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 221477_S_AT, 205419_AT, 
                   
               
               
                   
                   
                   
                   
                   
                   
                 204590_X_AT, 226218_AT 
                   
               
               
                 GO_BP 
                 GO:0048545 
                 response to steroid 
                 5.303315412 
                 0.001961629 
                 0.048188649 
                 202381_AT, 203980_AT, 207433_AT, 
                 ADAM9, FABP4, IL10, CCL5, GHRL, HMGB2, 
               
               
                   
                   
                 hormone stimulus 
                   
                   
                   
                 1555759_A_AT, 223862_AT, 
                 CCL2 
               
               
                   
                   
                   
                   
                   
                   
                 243368_AT, 216598_S_AT 
                   
               
               
                 GO_BP 
                 GO:0006959 
                 humoral immune response 
                 9.206478835 
                 0.00203972 
                 0.049246639 
                 219424_AT, 205419_AT, 201926_S_AT, 
                 EBI3, GPR183, CD55, TREM1, CCL2, CD55 
               
               
                   
                   
                   
                   
                   
                   
                 219434_AT, 216598_S_AT, 1555950_A_AT 
               
               
                   
               
             
          
         
       
     
       Example 4 
     Validation of Pro-Inflammatory Markers&#39; Upregulation by Stimulation with Probioglat Compared to Copaxone® (gRT-PCR Analysis) 
       [0338]    Key genes identified by differential expression analysis were assayed using qRT-PCR. RNA was utilized from each of 6 biological samples for each treatment (Copaxone and Probioglat) and 15 technical replicates were performed for each sample (a total of 90 observations per transcript per treatment). Since three Copaxone® batches and one Probioglat batch were available, a total of 360 observations from each transcript were evaluated. To evaluate the data, the 2 −ΔΔct  approximation was utilized with GAPDH as reference transcript and vehicle control (mannitol) as calibrator. A one-sided t-test with unequal variance was used to compare the RNA expression from the two treatments. 
         [0339]    To validate the results from the microarrays comparing Probioglat with Copaxone® for key inflammation and MS-related genes, two chemokines (CCL5, FDR p-value&lt;0.02 and CXCL10, FDR p-value&lt;0.0006), two matrix metalloproteinases (MMP1, FDR p-value&lt;0.002 and MMP9, FDR p-value&lt;2.8e-6) and a non-secreted cell surface marker (CD9, FDR p-value&lt;0.002 with FC 1.15) that is a component of myelin and a marker of myelinogenic progenitor cells (Allie et al., Arch. Neurol. 2005) were tested independently by robust qRT-PCR analysis. Three Copaxone® batches and one Probioglat batch were available for use, and a total of 360 observations from each transcript were evaluated. Statistical analysis utilized a one-sided t-test with unequal variance to compare the RNA expression from the two treatments. All the genes tested were significantly differentially expressed between Probioglat and Copaxone as expected based on the microarray analysis (Table 7). 
         [0000]    
       
         
               
             
               
               
             
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
               
               
             
           
               
                 TABLE 7 
               
             
             
               
                   
               
               
                 Differential expression (p value and fold change) of key immunological genes 
               
               
                 following Probioglat stimulation compared with Copaxone ® 
               
             
          
           
               
                   
                 Genes 
               
             
          
           
               
                   
                 CCL5 
                 CD9 
                 CXCL10 
                 MMP1 
                 MMP9 
               
             
          
           
               
                 Method 
                 FC 
                 p value 
                 FC 
                 p value 
                 FC 
                 p value 
                 FC 
                 p value 
                 FC 
                 p value 
               
               
                   
               
             
          
           
               
                 qPCR 
                 1.12 
                 4.05E−05 
                 1.11 
                 0.0004 
                 2.28 
                 0.0029 
                 1.25 
                 0.0201 
                 1.24 
                 0.0168 
               
               
                 FDR- 
                 1.09 
                 0.02 
                 1.15 
                 0.002 
                 1.46 
                 0.0006 
                 1.5 
                 0.002 
                 1.29 
                 2.80E−06 
               
               
                 adjusted 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 Microarray 
               
               
                   
               
               
                 FC: fold change; qPCR; quantitative RT-PCR; FDR: For the microarray data, since all probesets on the microarray were tested, p values were adjusted using FDR for testing multiple hypotheses. 
               
             
          
         
       
     
         [0340]    Table 7 shows p-values from single-tailed t-test with unequal variance (for qPCR results) and FDR-adjusted p-values from LIMMA comparison of microarray data between human monocytes treated with Copaxone® and Probioglat. 
       Discussion 
     Examples 3-4 
       [0341]    The genes significantly upregulated (FDR adjusted p value&lt;0.05) in Probioglat relative to Copaxone® treatment at 6 hours were found to be enriched significantly (Benjamini corrected p value&lt;0.05) for 106 pathways annotated in the GO (Biological Process, Cellular Component, and Molecular Function) and Kegg databases (The Gene Ontology Consortium. Gene ontology: tool for the unification of biology, Nat. Genet., May 2000; Kanehisa et al, KEGG: Kyoto Encyclopedia of Genes and Genomes, N A R, 2000) ( FIG. 10 ; Table 6). These include immune system process (GO:0002376), response to lipopolysaccharide (LPS) (GO:0032496), and immune response (GO:0006955) pathways (Benjamini corrected p values 1.5e-5, 8.7e-4, and 3.3e-4, respectively). Several of these pathways are relevant to inflammation (e.g., regulation of inflammatory response (GO:0050727) and regulation of tumor necrosis factor production (GO:0032680), Benjamini corrected p values of 0.015 and 0.028, respectively). 
         [0342]    Branded GA significantly modulated many validated pathways. At 6 hours, pathways enriched significantly among upregulated genes included broad categories such as immune response and regulation of immune processes, and more specifically cytokine-cytokine receptor interactions. Other significantly enriched pathways included adhesion; extracellular region; plasma membrane; membrane; response to external stimulus; response to stress; response to wounding; defense response; inflammatory response; and immune system process, all pathways with broad relevance to the disease process and/or proposed action of GA. Several of these pathways (e.g., extracellular region; immune system process; defense response; regulation of leukocyte activation) were also seen significantly enriched among genes modulated by GA in monocytes obtained from RRMS patients within the first two months of treatment (Thamilarasan, J Neuroinflammation 2013). 
         [0343]    As another example, NOD-like receptor signaling (hsa04621, Benjamini corrected p value 0.027) regulates inflammatory and apoptotic responses. The response to LPS pathway (GO:0050727;  FIG. 9 ) includes the genes CD14, CCL5, THBD, CARD15, NFKBIA, and CCL2, all upregulated in Probioglat treatment versus GA at 6 hours. This pathway was also significantly enriched among probesets upregulated by GA treatment at 6 hours, though with a lower enrichment score (14.8 vs 2.7) and higher p value (0.00087 vs 0.036). The strong enrichment induced by Probioglat relative to GA of this prototypical pro-inflammatory pathway warrants further investigation with respect to safety. 
         [0344]    Interestingly, about half of the pathways (58 out of 114) significantly enriched (Benjamini corrected p value&lt;0.05) among genes upregulated by GA treatment versus mannitol control at 6 hours were also significantly enriched among genes upregulated by Probioglat relative to GA treatment. An additional 48 pathways were significantly enriched among genes upregulated by Probioglat relative to GA (and not modulated by GA relative to mannitol control). These include pathways relevant to inflammation, such as response to molecule of bacterial origin (GO:0002237), regulation of tumor necrosis factor production (GO:0032680) and NOD-like receptor signaling pathway (hsa04621), as well as other immune pathways including regulation of lymphocyte mediated immunity (GO:0002706) and B cell proliferation (GO:0042100). 
       Example 5 
     Integrated Analysis Spanning Multiple Species and Cell Types 
       [0345]    Analyses were conducted to elucidate the gene expression changes induced by Copaxone® in the following systems:
       1) primed, ex vivo mouse splenocytes;   2) THP-1 human monocyte cell line; and   3) samples from MS patients.       
 
         [0349]    Genes, pathways and immune cell types modulated by Copaxone® were investigated, in order to determine which aspects of Copaxone®&#39;s mechanism were observed across all systems utilized, and which were detectable only in certain systems, but not others. 
         [0350]    Genome-wide expression profiles in cells from three different datasets in two different species (human, mouse) were studied. LIMMA was utilized to identify a genome-wide list of differentially expressed genes induced by GA in the primed and ex vivo stimulated mouse splenocytes, as well as in the THP-1 human monocyte cell line. Repeated-measures ANOVA was utilized to find a genome-wide list of genes modulated by GA in treated MS patients. Advanced enrichment algorithms were then applied to elucidate the pathways and cell types modulated by GA. 
         [0351]    Upregulated expression of the IL-10 gene, a key indicator of the well-studied Th2-shift induced by GA, was consistently demonstrated in all 3 systems (mouse splenocytes, human monocytes and MS patient PBMCs) ( FIG. 13 ). GA induces an anti-inflammatory effect, mediated by secretion of IL-4, IL-10, and other anti-inflammatory cytokines. This effect involves both a shift in T cell populations (from pro-inflammatory Th1 to anti-inflammatory Th2) and a shift from monocyte production of IL12 to anti-inflammatory IL10. For example, in vitro GA treatment increased the proportion of IL10-producing Treg cells in blood from MS patients (Putheti, J Neuroimmunol 2003). Dendritic cells exposed to GA during maturation increased their production of IL10 (Vieira et al, J Immunol 2003), monocytes from mice treated with GA secreted more IL10 than monocytes from untreated mice (Weber et al, Nat Med 2007), and monocytes isolated from MS patients treated with GA were shown to upregulate IL10 relative to untreated patients (Kim et al, J Immunol 2004). 
         [0352]    The genes modulated by GA treatment in multiple studies were examined for enrichment in particular immunological cell types. 39 genes were modulated significantly by GA in all three studies ( FIG. 14 ). Table 8 shows the expression level of each gene as modulated by Copaxone® compared to baseline (human PBMC), mannitol (human monocyte) or medium (mouse splenocytes). Although some genes are significantly differentially expressed in the same direction across all compartments and systems, other genes are modulated differently across the different systems. This shows that Copaxone® may induce pathways or cell types differently depending on a given experimental setup and a well-designed genome-wide assay is required to ascertain mechanism and effect of Copaxone®. Starred genes did not meet effect size cutoff of 0.5 employed in human PBMC study for conducting enrichments. 
         [0000]    
       
         
               
             
               
               
               
               
               
             
           
               
                 TABLE 8 
               
             
             
               
                   
               
               
                 Genes significantly modulated by Copaxone ® treatment in 
               
               
                 all three studies 
               
             
          
           
               
                   
                   
                 Direction in 
                 Direction in 
                 Direction in 
               
               
                   
                   
                 human 
                 human 
                 mouse 
               
               
                   
                   
                 PBMC 
                 monocytes 
                 splenocytes 
               
               
                   
                   
                 (Copaxone 
                 (Copaxone 
                 (Copaxone 
               
               
                   
                   
                 relative to 
                 relative to 
                 relative to 
               
               
                   
                 Gene 
                 Baseline) 
                 Mannitol) 
                 Medium) 
               
               
                   
                   
               
               
                   
                 ABCF2 
                 DOWN 
                 DOWN 
                 UP 
               
               
                   
                 ABI2 
                 UP 
                 UP 
                 UP 
               
               
                   
                 ACP6 
                 DOWN 
                 DOWN 
                 DOWN 
               
               
                   
                 AFG3L2 
                 DOWN 
                 DOWN 
                 UP 
               
               
                   
                 ALMS1 
                 DOWN 
                 UP 
                 UP 
               
               
                   
                 ARPC4 
                 UP 
                 UP 
                 UP 
               
               
                   
                 CALM3 
                 UP 
                 DOWN 
                 DOWN 
               
               
                   
                 CCDC64 
                 UP 
                 DOWN 
                 DOWN 
               
               
                   
                 CD84 
                 UP 
                 UP 
                 DOWN 
               
               
                   
                 CDC6 
                 UP 
                 DOWN 
                 UP 
               
               
                   
                 CHAF1A 
                 DOWN 
                 DOWN 
                 UP 
               
               
                   
                 CLU 
                 UP 
                 UP 
                 DOWN 
               
               
                   
                 COX11 
                 DOWN 
                 DOWN 
                 UP 
               
               
                   
                 DLGAP1 
                 DOWN 
                 UP 
                 DOWN 
               
               
                   
                 DTX4 
                 DOWN 
                 UP 
                 DOWN 
               
               
                   
                 FAM49B 
                 DOWN 
                 UP 
                 UP 
               
               
                   
                 FHL1 
                 UP 
                 DOWN 
                 DOWN 
               
               
                   
                 FNTB 
                 UP 
                 DOWN 
                 DOWN 
               
               
                   
                 GYPC 
                 UP 
                 DOWN 
                 DOWN 
               
               
                   
                 HFE 
                 UP 
                 UP 
                 UP 
               
               
                   
                 IL10* 
                 UP 
                 UP 
                 UP 
               
               
                   
                 LPHN1 
                 DOWN 
                 DOWN 
                 DOWN 
               
               
                   
                 NACA* 
                 DOWN 
                 DOWN 
                 UP 
               
               
                   
                 CLAH 
                 DOWN 
                 DOWN 
                 UP 
               
               
                   
                 PATZ1 
                 UP 
                 DOWN 
                 DOWN 
               
               
                   
                 PDK1 
                 UP 
                 DOWN 
                 DOWN 
               
               
                   
                 POLI 
                 DOWN 
                 DOWN 
                 DOWN 
               
               
                   
                 REEP5 
                 DOWN 
                 UP 
                 DOWN 
               
               
                   
                 RPL5* 
                 DOWN 
                 UP 
                 DOWN 
               
               
                   
                 RPS6KA2 
                 DOWN 
                 UP 
                 DOWN 
               
               
                   
                 SEC31A 
                 DOWN 
                 DOWN 
                 DOWN 
               
               
                   
                 SETBP1 
                 DOWN 
                 UP 
                 DOWN 
               
               
                   
                 SNRPA1 
                 DOWN 
                 DOWN 
                 UP 
               
               
                   
                 SYNCRIP 
                 DOWN 
                 DOWN 
                 DOWN 
               
               
                   
                 TNF5F9 
                 DOWN 
                 DOWN 
                 UP 
               
               
                   
                 TOMM40 
                 DOWN 
                 DOWN 
                 UP 
               
               
                   
                 TPM1 
                 UP 
                 DOWN 
                 DOWN 
               
               
                   
                 TSHZ1* 
                 DOWN 
                 DOWN 
                 DOWN 
               
               
                   
                 TSP4N13 
                 DOWN 
                 DOWN 
                 DOWN 
               
               
                   
                 U6AP2 
                 DOWN 
                 DOWN 
                 UP 
               
               
                   
                 VAV3 
                 DOWN 
                 UP 
                 DOWN 
               
               
                   
                 VDAC2 
                 DOWN 
                 DOWN 
                 UP 
               
               
                   
                 ZFAND6 
                 DOWN 
                 UP 
                 DOWN 
               
               
                   
                   
               
             
          
         
       
     
       Example 6 
     Cell Type Enrichment Analysis 
       [0353]    In addition to the shared induced effects discussed above, each system and platform clearly captured different aspects of GA&#39;s impact on the immune system. In mouse splenocytes, genes associated with FOXP3+ regulatory T cells (Tregs), B cells, T cells in general, macrophages, and dendritic cells were significantly modulated upon ex vivo stimulation with GA after prior inoculation (Table 9). In human monocyte (THP-1) cells, upregulated genes were associated with monocytes along with NK cells, dendritic cells, and granulocytes (Table 10). In human PBMCs, genes associated with immune cell types were modulated early in treatment (by month 3), including certain cell types affected in prior systems, but also distinct cell types, such as megakaryocytes and myeloid progenitors (Table 11). 
         [0000]    
       
         
               
             
               
               
               
               
             
               
             
               
               
               
               
             
               
             
               
               
               
               
             
           
               
                 TABLE 9 
               
             
             
               
                   
               
               
                 Immunological cell type enrichment for genes modulated by GA 
               
               
                 treatment in mouse splenocytes 
               
             
          
           
               
                 Dataset Name 1   
                 Score 
                 p.val 
                 adj.p.val 
               
               
                   
               
             
          
           
               
                 a) Upregulated (top 20 results) 
               
             
          
           
               
                 SC.MEP.BM.rnk 
                 641.2372079 
                 0 
                 0 
               
               
                 T.8Eff.Sp.OT1.12hr. 
                 683.0376678 
                 0 
                 0 
               
               
                 LisOva.rnk 
               
               
                 T.8Eff.Sp.OT1.48hr. 
                 587.7303361 
                 0 
                 0 
               
               
                 LisOva.rnk 
               
               
                 T.DPbl.Th.rnk 
                 659.3284877 
                 0 
                 0 
               
               
                 T.ISP.Th.rnk 
                 584.8660167 
                 0 
                 0 
               
               
                 preB.FrC.BM.rnk 
                 620.1611981 
                 0 
                 0 
               
               
                 proB.FrBC.FL.rnk 
                 595.3446445 
                 0 
                 0 
               
               
                 DC.LC.Sk.rnk 
                 709.8843317 
                 2.89E−15 
                 6.96E−14 
               
               
                 NK.H..MCMV1.Sp.rnk 
                 770.77198 
                 7.11E−15 
                 1.52E−13 
               
               
                 DC.103.11b..PolyIC.Lu.rnk 
                 704.9643794 
                 1.44E−14 
                 2.65E−13 
               
               
                 NK.MCMV1.Sp.rnk 
                 793.3059033 
                 1.51E−14 
                 2.65E−13 
               
               
                 T.8Eff.Sp.OT1.24hr. 
                 661.8125467 
                 5.97E−14 
                 9.61E−13 
               
               
                 LisOva.rnk 
               
               
                 B.GC.Sp.rnk 
                 602.4630175 
                 1.01E−12 
                 1.39E−11 
               
               
                 Tgd.vg2.24ahi.e17.Th.rnk 
                 619.9621246 
                 9.88E−13 
                 1.39E−11 
               
               
                 DC.103.11b.24..Lu.rnk 
                 738.2608372 
                 8.91E−12 
                 1.15E−10 
               
               
                 T.4FP3.25..AA.rnk 
                 697.5960229 
                 2.76E−11 
                 3.14E−10 
               
               
                 Tgd.vg3.24alo.e17.Th.rnk 
                 620.789896 
                 2.72E−11 
                 3.14E−10 
               
               
                 proB.FrA.FL.rnk 
                 578.5853958 
                 7.17E−11 
                 7.69E−10 
               
               
                 preT.DN3B.Th.rnk 
                 567.9618687 
                 1.64E−10 
                 1.67E−09 
               
               
                 preT.DN3.4.Th.rnk 
                 560.7279837 
                 2.96E−10 
                 2.86E−09 
               
             
          
           
               
                 b) Downregulated (top 20 results) 
               
             
          
           
               
                 GN.Arth.BM.rnk 
                 1217.738372 
                 0 
                 0 
               
               
                 SC.CDP.BM.rnk 
                 1077.505969 
                 0 
                 0 
               
               
                 T.4SP24int.Th.rnk 
                 1040.246786 
                 0 
                 0 
               
               
                 T.8Nve.Sp.OT1.rnk 
                 1095.134864 
                 0 
                 0 
               
               
                 proB.CLP.FL.rnk 
                 1115.01089 
                 0 
                 0 
               
               
                 GN.BM.rnk 
                 1212.480897 
                 1.11E−16 
                 3.57E−15 
               
               
                 GN.BI.rnk 
                 1184.87043 
                 6.66E−15 
                 1.84E−13 
               
               
                 GN.UrAc.PC.rnk 
                 1145.080376 
                 5.87E−14 
                 1.37E−12 
               
               
                 GN.Thio.PC.rnk 
                 1197.163456 
                 6.39E−14 
                 1.37E−12 
               
               
                 GN.Arth.SynF.rnk 
                 1160.159783 
                 2.72E−11 
                 5.25E−10 
               
               
                 DC.Ilhilang.103.11blo. 
                 1112.24759 
                 5.07E−08 
                 8.90E−07 
               
               
                 SLN.rnk 
               
               
                 DC.Ilhilang.103.11b..SLN.rnk 
                 1151.229363 
                 9.94E−08 
                 1.60E−06 
               
               
                 DC.8.4.11b..SLN.rnk 
                 1116.686609 
                 1.86E−07 
                 2.77E−06 
               
               
                 proB.CLP.BM.rnk 
                 1181.133013 
                 1.35E−06 
                 1.86E−05 
               
               
                 Mo.6C.Il..BM.rnk 
                 1094.697148 
                 1.71E−06 
                 2.20E−05 
               
               
                 DC.103.11b..LuLN.rnk 
                 1151.971571 
                 2.47E−06 
                 2.98E−05 
               
               
                 SC.GMP.BM.rnk 
                 1340.719659 
                 1.56E−05 
                 0.000164843 
               
               
                 SC.MDP.BM.rnk 
                 1206.224359 
                 1.56E−05 
                 0.000164843 
               
               
                 Mo.6C.Ilint.BI.rnk 
                 1106.765118 
                 1.62E−05 
                 0.000164843 
               
               
                   
               
               
                   1 All immunological cell type terminology in Tables 5-7 as defined via Immgen (www.immgen.org/). 
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
               
             
               
               
               
               
             
           
               
                 TABLE 10 
               
             
             
               
                   
               
               
                 Immunological cell type enrichment for genes upregulated by 
               
               
                 GA treatment in human monocytes. 
               
             
          
           
               
                 Dataset Name 
                 Score 
                 p.val 
                 adj.p.val 
               
               
                   
               
             
          
           
               
                 MONO2.rnk 
                 108.0701335 
                 0 
                 0 
               
               
                 NKA1.rnk 
                 97.70225302 
                 2.00E−15 
                 3.80E−14 
               
               
                 MONO1.rnk 
                 104.5121531 
                 8.28E−13 
                 1.05E−11 
               
               
                 GRAN2.rnk 
                 97.10283117 
                 1.17E−09 
                 1.11E−08 
               
               
                 GRAN3.rnk 
                 91.49890345 
                 1.27E−07 
                 9.40E−07 
               
               
                 DENDA2.rnk 
                 100.4177838 
                 1.48E−07 
                 9.40E−07 
               
               
                 DENDA1.rnk 
                 111.2455747 
                 7.78E−05 
                 0.000422143 
               
               
                 EOS2.rnk 
                 94.29494842 
                 0.000223937 
                 0.001063701 
               
               
                 MEGA2.rnk 
                 101.6956549 
                 0.007442566 
                 0.031424168 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
               
               
             
               
             
               
               
               
               
               
             
               
             
               
               
               
               
               
             
               
             
               
               
               
               
               
             
               
             
               
               
               
               
               
             
           
               
                 TABLE 11 
               
             
             
               
                   
               
               
                 Immunological cell type enrichment for genes modulated by 
               
               
                 GA treatment in human PBMC. 
               
             
          
           
               
                 Dataset Name 
                 Score 
                 p.val 
                 adj.p.val 
                 Genes in list &gt;= threshold 
               
               
                   
               
             
          
           
               
                 a) Upregulated, by cluster resulting from consensus k-means 
               
               
                 clustering on gene expression profiles 
               
               
                 Cluster 0: 
               
             
          
           
               
                 MEGA2.rnk 
                 32.42631137 
                 1.24E−12 
                 4.70E−11 
                 PTPN18, ILK, RAB27B, FHL1, EPOR, FYN, MAX, 
               
               
                   
                   
                   
                   
                 PARVB, TUBB1, TPM1, VCL, TPM4 
               
             
          
           
               
                 Cluster 2: 
               
             
          
           
               
                 PRE_BCELL3.rnk 
                 57.93896297 
                 3.98E−08 
                 1.51E−06 
                 IGL@, TOP2A, NUSAP1, IRF4, IGHM, 
               
               
                   
                   
                   
                   
                 IGL@, BIRC5 
               
               
                 ERY5.rnk 
                 64.22953395 
                 9.88E−07 
                 1.88E−05 
                 IGL@, TOP2A, NUSAP1, IGHM, MYL4, 
               
               
                   
                   
                   
                   
                 MKI67, IGL@, H2AFX, RPIP8, GYPC, 
               
               
                   
                   
                   
                   
                 BIRC5 
               
               
                 ERY2.rnk 
                 32.83132369 
                 8.43E−05 
                 0.001067894 
                 BUB1B, TOP2A, NUSAP1, MCM4, TUBB, 
               
               
                   
                   
                   
                   
                 MYL4, CDC6, BIRC5 
               
               
                 ERY4.rnk 
                 69.43612767 
                 0.000141687 
                 0.001346024 
                 TOP2A, NUSAP1, TUBB, MYL4, MKI67, 
               
               
                   
                   
                   
                   
                 CDC2, RPIP8, GYPC, BIRC5 
               
               
                 ERY3.rnk 
                 84.61769579 
                 0.000286865 
                 0.002180171 
                 BUB1B, TOP2A, NUSAP1, TUBB, MYL4, 
               
               
                   
                   
                   
                   
                 MKI67, CDC2, RPIP8, GYPC, BIRC5 
               
               
                 GRAN1.rnk 
                 55.17000868 
                 0.000557705 
                 0.003532132 
                 IGHG1, IGL@, TOP2A, NUSAP1, IRF4, 
               
               
                   
                   
                   
                   
                 IGHM, IGL@, BIRC5 
               
               
                 EOS2.rnk 
                 62.69263216 
                 0.002286284 
                 0.012411257 
                 IGL@, IRF4, IGHM, IGL@ 
               
               
                 BASO1.rnk 
                 87.29704767 
                 0.003219714 
                 0.013594346 
                 IGL@, IGHM, IGL@ 
               
               
                 ERY1.rnk 
                 28.25494881 
                 0.003043224 
                 0.013594346 
                 BUB1B, NUSAP1, MCM4, TUBB, MS4A2, 
               
               
                   
                   
                   
                   
                 BIRC5 
               
               
                 MEP.rnk 
                 30.5446045 
                 0.009387769 
                 0.035673524 
                 TOP2A, NUSAP1, MCM4, TUBB, MS4A2, 
               
               
                   
                   
                   
                   
                 BIRC5 
               
             
          
           
               
                 Cluster 4: 
               
             
          
           
               
                 MEGA2.rnk 
                 64.4584783 
                 4.41E−12 
                 1.67E−10 
                 PARD3, GNB5, C5ORF4, LIMS1, 
               
               
                   
                   
                   
                   
                 ACTN1, ITGB3, ITGA2B, GPX1, IGF2BP3, 
               
               
                   
                   
                   
                   
                 CLU, LTBP1 
               
               
                 MEGA1.rnk 
                 38.04817949 
                 4.66E−09 
                 8.86E−08 
                 HMGA2, LIMS1, ACTN1, ITGB3, 
               
               
                   
                   
                   
                   
                 ITGA2B, GPX1, IGF2BP3, LTBP1 
               
               
                 ERY2.rnk 
                 47.24788403 
                 4.70E−06 
                 5.96E−05 
                 HMGA2, LIMS1, ACTN1, ITGB3, 
               
               
                   
                   
                   
                   
                 ITGA2B, IGF2BP3, CLU, LTBP1 
               
               
                 GMP.rnk 
                 33.12681006 
                 0.000142682 
                 0.001355477 
                 ACTN1, GPX1, IGF2BP3, LTBP1 
               
               
                 HSC3.rnk 
                 45.40525942 
                 0.000287455 
                 0.002184658 
                 HMGA2, LIMS1, GPX1, IGF2BP3, 
               
               
                   
                   
                   
                   
                 HIST1H3D, LTBP1, INPP4B 
               
               
                 ERY5.rnk 
                 73.41821315 
                 0.000980846 
                 0.006212027 
                 CLCN3, C5ORF4, ITGB3, GPX1, 
               
               
                   
                   
                   
                   
                 IGF2BP3, LTBP1 
               
               
                 CMP.rnk 
                 23.1944575 
                 0.002214239 
                 0.010517637 
                 HMGA2, IGF2BP3 
               
               
                 ERY4.rnk 
                 77.37714483 
                 0.001966408 
                 0.010517637 
                 RAB6B, CLCN3, C5ORF4, GPX1, 
               
               
                   
                   
                   
                   
                 IGF2BP3, LTBP1 
               
               
                 ERY1.rnk 
                 45.00063371 
                 0.002587112 
                 0.010923363 
                 HMGA2, GPX1, IGF2BP3, MALL, 
               
               
                   
                   
                   
                   
                 LTBP1 
               
               
                 ERY3.rnk 
                 90.0166825 
                 0.009061135 
                 0.031302103 
                 RAB6B, CLCN3, C5ORF4, GPX1, 
               
               
                   
                   
                   
                   
                 IGF2BP3, LTBP1 
               
               
                 GRAN2.rnk 
                 35.17942767 
                 0.008750011 
                 0.031302103 
                 ACTN1, ITGB3, GPX1, IGF2BP3, 
               
               
                   
                   
                   
                   
                 LTBP1 
               
             
          
           
               
                 b) Downregulated, by cluster resulting from consensus k-means 
               
               
                 clustering on gene expression profiles (as described in methods) 
               
               
                 Cluster 0: 
               
             
          
           
               
                 BCELLA2.rnk 
                 −25.76679646 
                 0.000420072 
                 0.015962749 
                 ITSN1, ZNF365, GYG2 
               
               
                 BCELLA1.rnk 
                 −19.11170698 
                 0.002736809 
                 0.025999686 
                 ITSN1, ANK3, ZNF365, GYG2, EXTL2 
               
               
                 BCELLA3.rnk 
                 −20.11301566 
                 0.00138472 
                 0.025999686 
                 ITSN1, ZNF365, GYG2 
               
               
                 BCELLA4.rnk 
                 −21.51318153 
                 0.00253799 
                 0.025999686 
                 ITSN1, LILRA4, GYG2, EXTL2 
               
               
                   
               
             
          
         
       
     
       Discussion 
     Examples 5-6 
       [0354]    The diversity of the cell types enriched from the list of 1200 genes (B cells, T cells, monocyte progenitors, megakaryocytes) indicates the wide-ranging effects of Copaxone® on the immune system. Similar to what was observed in the splenocyte data, it is difficult to define a small panel of genes to use as quality-control measures against a given Copaxone® lot due to the wide-ranging effect of the drug. Using genome-wide gene-expression arrays, the gene expression from the human PBMC data, mouse splenocytes and human THP-1 monocyte cell line were compared and discovered that although there are genes that are consistently modulated by Copaxone® across all those experimental systems (e.g., IL10), some gene-expression signatures and cell types (e.g., B-cells) were seen only in one system (e.g., human PBMC data) but not as clearly in the other systems (e.g., monocytes and splenocyte data). Looking at genome-wide gene expression signatures can yield a good characterization of the impact of Copaxone® on a single system (e.g., THP-1 monocytes) but well-powered experiments in multiple systems are necessary to characterize the biological impact of Copaxone®. 
         [0355]    The generic glatiramer acetate manufactured by Probioglat induced significantly higher expression of CD14 than Copaxone® did (adj. p=0.0135;  FIG. 15 a   ) and also induced significantly higher expression of CD40 than Copaxone® did (adj. p=0.0128,  FIG. 15 b   ). One key element of Copaxone®&#39;s putative mechanism of action is the ability to shift the immune response from a Th1/Th17 phenotype, typically associated with MS pathoetiology and severity, to a Th2 response type that may mitigate the harmful effects of MS. Across multiple studies, we observed concerning differences between Copaxone® and proposed generics was observed in their impact on key genes associated with maintaining the balance between Th2 and Th1/Th17. 
         [0356]    Interleukin-1 beta (IL1B) is a cytokine that stimulates a variety of immune system cells, and may contribute to the development of MS by promoting Th17 cell development. Consistent with these observations, IL1B has also been found to be associated with late disability progression and neurodegeneration in MS. Glatiramer acetate, on the other hand, was reported to significantly reduce interleukin-1beta levels under chronic inflammatory conditions in vitro in human monocytes (p=0.028). 
         [0357]    A variety of glatiramoids were significantly less effective than Copaxone® at downregulating IL1B: Copaxone® induced significantly lower IL1B expression than a Natco purported generic in our first mouse splenocyte study (adjusted p=0.043 by ANOVA). Copaxone® was also extremely effective in downregulating IL1B relative to medium (adjusted p=5.72×10-7), while the Hangzhou purported generic (API, China) did not significantly downregulate IL1B relative to medium (adjusted p=0.159) ( FIG. 16 ). 
         [0358]    Other Th17-associated genes also seem to be modulated less effectively by purported generics than by Copaxone®. In human monocytes, CD44 was upregulated to a greater extent by Escadra635 than by Copaxone® (adj. p=0.04 by LIMMA at 6 hrs;  FIG. 17 ). CD44 has an established role in Th17 differentiation, specifically: “deletion of CD44 inhibited Th1/Th17 differentiation while simultaneously enhancing Th2/regulatory T cell differentiation. 
         [0359]    Th17 associated genes also vary from one batch of generics to another. In mouse splenocytes, IL27 was upregulated to significantly different extents by different batches of Escadra, namely Escadra635 and Escadra253 ( FIG. 18 ). IL27 has been proposed to have therapeutic effects in MS, due to its ability to suppress Th17 cells and stimulate neuroprotective factors. 
         [0360]    In human monocytes, Probioglat induces significantly higher expression of MMP9 than Copaxone does (Adj. p=2.07×10-5 by LIMMA for Copaxone vs. Probioglat at 6 hrs in human monocytes;  FIG. 19 ). MMP9 is an established biomarker and potential predictor of disease activity in MS. This finding is particularly concerning given the fact that MMP9 facilitates T-cell migration into the CNS, playing a key role in the disruption of the blood-brain barrier (BBB) and thus in the pathogenesis of MS. 
       Example 7 
     Compositional Differences of GARDPs and GARDSs 
       [0361]    Due to its molecular diversity, characterizing even a single, large polypeptide (assuming it could be isolated) would present significant technological and ° scientific barriers making full characterization, as well as a demonstration of active ingredient sameness, impossible. 
       Analysis of Additional Purported Generics Reveals Limitations of Focused Gene Panels 
       [0362]    Certain methods have been publicly described in patent application filings by manufacturers seeking to develop purported generics (including International Publication Number WO2008/157697 by Momenta Pharmaceuticals, Inc.), suggesting that glatiramoids can be compared by analyzing a panel comprising only a small subset of proteins and/or the genes coding for those proteins. To evaluate the effectiveness of such comparisons, we applied the same methods used to study Probioglat and Copaxone in human monocytes to also study purported generics Escadra (Raffo, Argentina) and Glatimer (Natco, India). Both purported generics modulated many genes to a significantly different extent than Copaxone. These differentially expressed genes included genes with relevance for multiple sclerosis. For instance, both Natco and Escadra differed significantly from Copaxone in expression of CD9, a component of myelin and a marker of myelinogenic progenitor cells (Sim et al, Nature Biotechnology, 2011). As another example, Escadra differed significantly from Copaxone in expression of CD44, the receptor for hyaluronan which accumulates in demyelinated lesions (Back et al, Nature Medicine, 2005). Despite significant differences such as these between Copaxone and the purported generics in expression of biologically relevant genes, when we examined only the small subset of genes coding for proteins identified in the Momenta patent, there were no significant differences in expression ( FIG. 20 ). This demonstrates that methods focusing on only a small selected subset of genes may miss important differences between two glatiramoids. 
       Compositional Differences can be Observed Between Copaxone and Other Generics 
       [0363]    TV-5010 was developed by making slight changes to the manufacturing process for Copaxone®, in order to produce a higher average molecular mass (in the range of 13,500-18,500 Daltons) and investigate whether such a change in molecular mass would be clinically beneficial. Surprisingly, TV-5010 proved toxic in long-term animal studies, inducing fibrosis, nephropathy, increases in eosinophil counts, and severe injection site lesions, including subcutaneous necrosis, vascular necrosis, cavity formation, and inflammation; in some cases these lesions were associated with mortality in both rats and monkeys, possibly related to vascular damage, hemorrhage, thrombus formation, and septicemia. These toxicities were never seen in any of the development programs for Copaxone, and led to the termination of TV-5010&#39;s development. Some patients treated with TV-5010 showed injection site reactions and/or developed anti-drug antibodies, but the clinical studies were completed in time to prevent any of the chronic toxicities observed in long-term animal studies from potentially occurring in humans. Because Copaxone® and TV-5010 had many similarities, with the two key differences that (1) TV-5010 had a higher average molecular mass than Copaxone®, and (2) Copaxone® was safe while TV-5010 induced toxicity in long-term animal studies, we sought to determine if there were genes differentially expressed in response to the two medicines that could have predicted toxicity prior to the initiation of long-term animal studies. Having generated gene expression profiles for TV-5010-stimulated splenocytes using the same procedures described above, we applied LIMMA to create a ranked list of genes with significantly different expression levels in response to TV-5010 compared to Copaxone, with both analyzed relative to medium. Among the genes with fold changes greater than 1.5, the gene with the lowest (best) p-value was Matrix Metalloproteinase 14 (MMP14). MMP14 expression was significantly higher in response to TV-5010 than in response to Copaxone® as determined by both ANOVA (adj p&lt;4.53×10-7) and LIMMA (adj P&lt;1.07×10-5) ( FIG. 21 ). 
         [0364]    The observed upregulation of MMP14 was striking because MMP14 has been associated with fibrosis and eosinophil-related disorders in the literature, the very same toxicities seen in animals following long-term treatment with TV-5010. MMP14 levels increase to over 250% of control correlating with the pattern of fibrosis manifestation in rats, and MMP14 activity is chronically elevated in a mouse model of dermal fibrosis. Moreover, in patients with the eosinophil-related disorder Eosinophilic Esophagitis (EoE), MMP14 is expressed at a 5.3-fold higher level than in controls. In addition to MMP14, another gene, Signal Transducer and Activator of Transcription 3 (STAT3), which has also been linked to fibrosis, also showed significantly elevated expression in response to TV-5010 relative to Copaxone®. Overall, our findings with TV-5010 lend further support to the utility of mouse splenocyte gene expression studies for predicting drug safety issues. 
       Example 8 
     Clinical Implications of the Use of Purported Generics 
       [0365]    Purported “generics” are not only different from Copaxone® in many ways, but also different from each other, causing differential effects in a variety of pathways modulating immunological processes that could have clinical and biological significance. The differences among “generics” highlight the importance of the manufacturing process for glatiramer acetate, and demonstrate that even slight changes in the manufacturing process can alter the biological properties of the resulting medicine ( FIG. 22 ). 
         [0366]    As part of Teva&#39;s ongoing commitment to better understand Copaxone®, Teva also has studied Copaxone®&#39;s effect at the level of gene expression across the entire genome (unbiased, without prior hypothesis about the genes for which expression pattern may be altered and without choosing which genes to focus on or study). Genes encode proteins which carry out an array of biological processes in the body, including processes that are essential to the immune system response manifested by exposure to Copaxone®. So-called gene “microarray technology” allows scientists to observe which genes are “turned on” (in scientific terms, “upregulated”), as well as which genes are “turned off” (in scientific terms, “downregulated”) after exposure to various conditions, including stimulation by pharmaceutical products, via measuring the level of mRNA, which is the transitional phase between genes and proteins along the translation process. Teva&#39;s gene expression analysis of mouse splenocytes, as well as a human monocyte cell line (THP-1), exposed to Copaxone®, reveals favorable, upregulation of anti-inflammatory genes. These studies provide support for the vast experimental evidence that Copaxone® exerts its well-established therapeutic benefits in part by modulating the immune system to turn on beneficial (i.e. anti-inflammatory and neuro-protective) genes and turn off harmful ones (i.e. pro-inflammatory). 
         [0367]    Several competitors have sought approval to market putative generic versions of the drug in foreign countries. Although many of those jurisdictions have required applicants to conduct clinical trials as a condition of approval—and none of those jurisdictions has approved a generic version of Copaxone®—others have not been as careful, and those countries since have allowed purported Copaxone generics to enter the market without proof of the equivalence of the putative generics to Copaxone®. 
         [0368]    In particular, the findings for Probioglat discussed below should be carefully addressed, given the serious clinical reports from Mexico following introduction of this purported generic to the market. The complaints expressed by MS patients treated with Probioglat in Mexico included adverse reactions (increased injection site reactions and post injection reactions) and increased occurrence of relapses, even in patients who had been stable for years under Copaxone treatment. These effects may be underlined by a biological imbalance between anti-inflammatory and pro-inflammatory processes, which may be discernible in gene expression differences such as those described herein. The pro-inflammatory signal identified in pre-clinical analyses and its potential association with boosting of the autoimmune mechanisms of disease following switching to Probioglat treatment should raise concerns for the potential health consequences of these differences. 
         [0369]    The Teva Patient Support Program in Mexico has an extensive database. Given that patients can switch between branded and purported generic GA, all patients are kept within the database and are provided with patient support services. Interestingly, the database shows differences in patient reports between 2012, when patients in the program were receiving only Copaxone, vs 2013, when patients were receiving both Copaxone® and Probioglat. 
         [0370]    The number of relapses reported by patients in Teva&#39;s Patient Support Program on a monthly basis during the years 2012 and 2013 i. It is again clear that when Copaxone alone was in use (i.e. throughout 2012) the overall, as well as per-month number of relapses was lower than that reported when Probioglat was present in the market (i.e. throughout 2013). 
       Discussion 
     Examples 7-8 
       [0371]    Gene expression data presented herein for Copaxone® further demonstrates the highly complex mechanism of action of GA, given that many of the GA-induced functional pathways in these experiments coincide with known mechanisms of GA activity in MS patients. Furthermore, the data suggests that other glatiramoids are associated with a significantly altered gene expression profile and thus would probably not behave the same as Copaxone. Most importantly, these biological differences could lead to a marked difference in safety or efficacy profile over the course of chronic treatment. 
         [0372]    Probioglat, a purported generic of Copaxone®, has been in commercial use in Mexico since January 2013. The introduction of Probioglat has resulted in a spike of injection site reactions and post injection reactions, as well as occurrence of relapses, even in patients who had been stably in remission for years. Accordingly, several pharmacovigilance reports have been issued by HCPs, and patients expressed complaints in the local media and in Teva&#39;s Patient Support Program. 
         [0373]    The high occurrence of relapses and adverse events after the treatment switch to Probioglat may be due to an immunological imbalance favoring pro-inflammatory effects, instead of the well recorded beneficial effect that Copaxone induces, reducing pro-inflammation and boosting anti-inflammation. 
         [0374]    Overall, similarities in the physicochemical properties of the glatiramer acetate mixture are observed between Copaxone and Probioglat, as well as other purported generics, particularly when using common non-specific analytical methods. However, clear differences are observed between Copaxone and purported generics when applying high resolution methodologies targeted at characterizing functionally relevant elements, e.g. IMMS analyses concomitantly capturing composition, size and charge distribution; and gene expression analyses capturing pro-inflammation distinctly upregulated by purported generics but not Copaxone®. 
         [0375]    Gene expression studies thus help explain the biological impact of the physicochemical differences observed, providing insight into some of the factors that may underlie the observed reduction in efficacy and parallel increase in adverse events reported with purported generic glatiramer acetate, notably Probioglat in Mexico. 
         [0376]    As part of Teva&#39;s ongoing commitment to better understand Copaxone®, Teva studies its effect at the level of gene expression across the entire genome (unbiased, without prior hypothesis about the genes for which expression pattern may be altered and without choosing which genes to focus on or study) in a variety of immunologically relevant model systems, including mouse splenocytes, human monocytes, and peripheral blood mononucleated cells (PBMCs) from MS patients. The genome-wide approach is critical, because two glatiramoids can appear identical based on a small panel of genes, yet differ significantly in their impact on other genes that are potentially highly relevant to safety and/or efficacy. Using multiple model systems is equally critical, since acting as an antigen, Copaxone significantly impacts a variety of immunological cell types. The unbiased approach allows identification of genes and pathways with subtle, yet robust, differential expression patterns following stimulation by different glatiramoids in different experimental contexts. The functionality of identified genes and pathways is then described based on experimental data reported in the peer-reviewed literature. The research has also shown that various model systems capture different aspects of Copaxone&#39;s mechanism of action, such that no single cell type or system tested was sufficient to fully characterize the biological impact of this medicine. 
       Example 9 
     Differences in Gene Expression Induced by Polimunol Versus Branded GA 
       [0377]    To identify differences between Copaxone® and differently manufactured glatiramoids, differential gene expression analysis was performed in this study to compare directly between profiles induced by Copaxone® and by the purported generic Polimunol. Based on previous power calculations (using the R package ssize.fdr), to detect differentially-expressed genes with a fold-change between treatments of as low as 1.3 with 80% power the experiment was designed to include six replicates of each condition. The order of sample processing was randomized with respect to treatment in order to avoid creating confounding batch effects. 
         [0378]    Cells from a human monocyte cell line (THP-1) were stimulated with either Copaxone®, purported generics from several manufacturers including Polimunol by Synthon, or vehicle control (mannitol) for 6 hours. The 6 hour timepoint was selected because the greatest effects across all treatments were observed at this timepoint in the previous study described above in Example 1. RNA was extracted and expression profiled genome-wide using the Affymetrix U133 Plus 2.0 chip. Three batches of Copaxone® and one batch of Polimunol were comparatively tested in six replicates each. RNA processing was performed by Expression Analysis (NC, USA). 
         [0379]    Differentially-expressed probesets were identified across conditions using linear models for microarray data (LIMMA). For comparing Copaxone® (“GA”) and purported generic, comparisons were corrected for mannitol control (i.e., [GA vs mannitol] was compared to [purported generic vs mannitol]). Probesets were filtered by calls of presence on the chip for the relevant samples in the comparison (to be considered present at a given timepoint, a probeset was required to have on average a call of present or marginal across the relevant samples at that timepoint). Probesets were mapped to genes using the U133 Plus 2.0 chip annotation from Affymetrix. Unless otherwise specified, all probesets called present for a gene showed the effect discussed above; where all multiple probesets were present for a gene, p values are reported for the most significant probeset. 
         [0380]    Upregulated and downregulated genes were analyzed separately for pathway enrichment, using DAVID [Huang, D. W., Sherman, B. T. &amp; Lempicki, R. A. Bioinformatics enrichment tools: paths toward the comprehensive functional analysis of large gene lists.  Nucleic Acids Res.  37, 1-13 (2009)]. Pathway enrichment results were visualized using volcano plots, plotting −log p-values versus enrichment scores. For GA MOA, to obtain top-gene lists of appropriate size (tens-hundreds) for use with DAVID, an absolute-value fold-change cutoff of 1.5 and p-value cutoff of 1e-3 were utilized to obtain gene lists for pathway enrichment. For comparisons between GA and Polimunol, upregulated or downregulated genes with FDR-adjusted p-values&lt;0.05 were used for pathway enrichment. DAVID runs were conducted on Sep. 12, 2014. Please note that the GO databases are updated daily (as noted on the GO site:www.geneontology.org/GO.downloads.ontology.shtml) and therefore performing the same enrichments on the same genesets may yield slightly varying results depending on the rundate. Pathway p-values may change slightly between runs conducted at different times; the overall picture of enriched pathways, however, is expected to remain consistent. 
         [0381]    Genes differentially expressed between Copaxone® and mannitol control are enriched with a variety of pathways in Kegg and GO (molecular function (MF), biological process (BP), and cellular component (CC)), many of which affect immunological responses, demonstrating Copaxone&#39;s complex mechanism of action, as shown in  FIG. 23 . Pathways enriched among top probesets modulated by Copaxone versus mannitol control are shown in Table 12. More than 80% of the pathways that enriched among top upregulated genes in the previous study were also enriched among top upregulated genes in the current study. 
         [0382]    As an example at the individual gene level, IL1RN was significantly upregulated (adjusted p&lt;2.8e-10), as shown in  FIG. 24 , which is consistent with the previous study described in Example 1 above. This gene encodes for the protein IL-1ra, which inhibits the activities of pro-inflammatory cytokines IL-1a and IL-1b. 
         [0383]    The probeset for IL10, which had been observed to be upregulated by Copaxone® above in Example 1, was called absent in this experiment, but was nominally upregulated (p&lt;0.029). However, the IL10 receptor IL10RA was significantly upregulated (for the single probeset for this gene, which was called present) (adjusted p&lt;2.8e-14). 
         [0384]    Genes analyzed for pathway enrichment (Table 12), using DAVID (conducted Sep. 12, 2014). Performing the same enrichments on the same genesets may yield slightly varying results depending on the run date (GO databases are updated daily: www.geneontology.org/GO.downloads.ontology.shtml). 
         [0000]    
       
         
               
             
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
               
               
             
           
               
                 TABLE 12 
               
               
                   
               
               
                 Human monocyte study: pathways significantly enriched among genes significantly upregulated by Copaxone ® relative to mannitol at 6 hours 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                   
                   
                   
                   
                   
                   
                   
                   
                   
                 Fold 
                   
                   
                   
               
               
                   
                 Category 
                 Term 
                 Count 
                 % 
                 Pvalue 
                 List Total 
                 Pop Hits 
                 Pop Total 
                 Enrichment 
                 Bonferroni 
                 Benjamini 
                 FDR 
               
               
                   
               
               
                   
                 GOTERM —   
                 GO:005886~plasma 
                 121 
                 35.17 
                 6.53E−20 
                 305 
                 1699 
                 9576 
                 2.236 
                 1.78E−17 
                 1.78E−17 
                 8.60E−17 
               
               
                   
                 CC_ALL 
                 membrane 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0050895~response 
                 127 
                 36.92 
                 4.65E−19 
                 291 
                 1815 
                 8731 
                 2.099 
                 1.01E−15 
                 1.01E−15 
                 8.07E−16 
               
               
                   
                 BP_ALL 
                 to stimulus 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0009605~response 
                 57 
                 16.57 
                 9.39E−17 
                 291 
                 492 
                 8731 
                 3.476 
                 2.42E−13 
                 1.21E−13 
                 1.89E−13 
               
               
                   
                 BP_ALL 
                 to external stimulus 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0009611~response 
                 40 
                 11.63 
                 1.44E−14 
                 291 
                 281 
                 8731 
                 4.271 
                 3.15E−11 
                 1.05E−11 
                 2.51E−11 
               
               
                   
                 BP_ALL 
                 to wounding 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0005887~integral 
                 53 
                 15.41 
                 1.31E−13 
                 305 
                 528 
                 9576 
                 3.152 
                 3.57E−11 
                 1.79E−11 
                 1.73E−10 
               
               
                   
                 CC_ALL 
                 to plasma membrane 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0031226~intrinsic 
                 53 
                 15.41 
                 2.60E−13 
                 305 
                 537 
                 9576 
                 3.099 
                 7.08E−11 
                 2.36E−11 
                 3.42E−10 
               
               
                   
                 CC_ALL 
                 to plasma membrane 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0005576~extracellular 
                 59 
                 17.15 
                 6.56E−13 
                 305 
                 662 
                 9576 
                 2.798 
                 1.79E−10 
                 4.46E−11 
                 8.64E−10 
               
               
                   
                 CC_ALL 
                 region 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0044421~extracellular 
                 39 
                 11.34 
                 1.93E−12 
                 305 
                 324 
                 9576 
                 3.779 
                 5.26E−10 
                 1.05E−10 
                 2.54E−09 
               
               
                   
                 CC_ALL 
                 region part 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0050793~regulation 
                 46 
                 13.37 
                 4.84E−13 
                 291 
                 406 
                 8731 
                 3.399 
                 1.06E−09 
                 2.64E−10 
                 8.41E−10 
               
               
                   
                 BP_ALL 
                 of developmental process 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0051239~regulation 
                 50 
                 14.53 
                 1.43E−11 
                 291 
                 517 
                 8731 
                 2.902 
                 3.12E−08 
                 6.23E−09 
                 2.48E−08 
               
               
                   
                 BP_ALL 
                 of multicellular 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 organismal process 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0004872~receptor 
                 54 
                 15.70 
                 4.34E−11 
                 297 
                 637 
                 9375 
                 2.676 
                 2.57E−08 
                 1.28E−08 
                 6.40E−08 
               
               
                   
                 MF_ALL 
                 activity 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0060089~molecular 
                 68 
                 19.77 
                 2.37E−11 
                 297 
                 915 
                 9375 
                 2.346 
                 1.40E−08 
                 1.40E−08 
                 3.49E−08 
               
               
                   
                 MF_ALL 
                 transducer activity 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0004871~signal 
                 68 
                 19.77 
                 2.37E−11 
                 297 
                 915 
                 9375 
                 2.346 
                 1.40E−08 
                 1.40E−08 
                 3.49E−08 
               
               
                   
                 MF_ALL 
                 transducer activity 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:004888~transmembrane 
                 36 
                 10.47 
                 1.44E−10 
                 297 
                 325 
                 9375 
                 3.497 
                 8.53E−08 
                 2.84E−08 
                 2.12E−07 
               
               
                   
                 MF_ALL 
                 receptor activity 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0001568~blood 
                 25 
                 7.27 
                 8.49E−11 
                 291 
                 148 
                 8731 
                 5.068 
                 1.86E−07 
                 3.09E−08 
                 1.48E−07 
               
               
                   
                 BP_ALL 
                 vessel development 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0044459~plasma 
                 73 
                 21.22 
                 7.32E−10 
                 305 
                 1095 
                 9576 
                 2.093 
                 1.99E−07 
                 3.32E−08 
                 9.63E−07 
               
               
                   
                 CC_ALL 
                 membrane part 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0048731~system 
                 83 
                 24.13 
                 1.24E−10 
                 291 
                 1231 
                 8731 
                 2.023 
                 2.70E−07 
                 3.38E−08 
                 2.15E−07 
               
               
                   
                 BP_ALL 
                 development 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0048514~blood 
                 23 
                 6.69 
                 1.43E−10 
                 291 
                 127 
                 8731 
                 5.434 
                 3.12E−07 
                 3.46E−08 
                 2.48E−07 
               
               
                   
                 BP_ALL 
                 vessel morphogenesis 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0001944~vasculature 
                 25 
                 7.27 
                 1.14E−10 
                 291 
                 150 
                 8731 
                 5.001 
                 2.48E−07 
                 3.54E−08 
                 1.97E−07 
               
               
                   
                 BP_ALL 
                 development 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0006950~response 
                 76 
                 22.09 
                 2.20E−10 
                 291 
                 1089 
                 8731 
                 2.094 
                 4.80E−07 
                 4.80E−08 
                 3.81E−07 
               
               
                   
                 BP_ALL 
                 to stress 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0006955~immune 
                 38 
                 11.05 
                 4.63E−10 
                 291 
                 356 
                 8731 
                 3.203 
                 1.01E−06 
                 9.19E−08 
                 8.04E−07 
               
               
                   
                 BP_ALL 
                 response 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0006952~defense 
                 35 
                 10.17 
                 6.58E−10 
                 291 
                 311 
                 8731 
                 3.377 
                 1.44E−06 
                 1.20E−07 
                 1.14E−06 
               
               
                   
                 BP_ALL 
                 response 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0032501~multicellular 
                 112 
                 32.56 
                 1.21E−09 
                 291 
                 1991 
                 8731 
                 1.688 
                 2.64E−06 
                 2.03E−07 
                 2.10E−06 
               
               
                   
                 BP_ALL 
                 organismal process 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0006954~inflammatory 
                 25 
                 7.27 
                 2.58E−09 
                 291 
                 174 
                 8731 
                 4.311 
                 5.64E−06 
                 3.76E−07 
                 4.48E−06 
               
               
                   
                 BP_ALL 
                 response 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0007275~multicellular 
                 93 
                 27.03 
                 2.50E−09 
                 291 
                 1544 
                 8731 
                 1.807 
                 5.47E−06 
                 3.90E−07 
                 4.35E−06 
               
               
                   
                 BP_ALL 
                 organismal development 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0040011~locomotion 
                 29 
                 8.43 
                 4.62E−09 
                 291 
                 238 
                 8731 
                 3.656 
                 1.01E−05 
                 6.30E−07 
                 8.02E−06 
               
               
                   
                 BP_ALL 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0032502~developmental 
                 100 
                 29.07 
                 5.35E−09 
                 291 
                 1738 
                 8731 
                 1.726 
                 1.17E−05 
                 6.49E−07 
                 9.30E−06 
               
               
                   
                 BP_ALL 
                 process 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0048545~response 
                 19 
                 5.52 
                 5.22E−09 
                 291 
                 102 
                 8731 
                 5.589 
                 1.14E−05 
                 6.71E−07 
                 9.07E−06 
               
               
                   
                 BP_ALL 
                 to steroid hormone 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 stimulus 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0005615~extracellular 
                 27 
                 7.85 
                 2.53E−08 
                 305 
                 235 
                 9576 
                 3.607 
                 6.89E−06 
                 9.84E−07 
                 3.34E−05 
               
               
                   
                 CC_ALL 
                 space 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0048856~anatomical 
                 84 
                 24.42 
                 8.74E−09 
                 291 
                 1366 
                 8731 
                 1.845 
                 1.91E−05 
                 1.01E−06 
                 1.52E−05 
               
               
                   
                 BP_ALL 
                 structure development 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0048583~regulation 
                 30 
                 8.72 
                 1.29E−08 
                 291 
                 265 
                 8731 
                 3.397 
                 2.82E−05 
                 1.41E−06 
                 2.24E−05 
               
               
                   
                 BP_ALL 
                 of response to 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 stimulus 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0002376~immune 
                 47 
                 13.66 
                 1.94E−08 
                 291 
                 578 
                 8731 
                 2.440 
                 4.25E−05 
                 2.02E−06 
                 3.38E−05 
               
               
                   
                 BP_ALL 
                 system process 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0031012~extracellular 
                 18 
                 5.23 
                 8.69E−08 
                 305 
                 113 
                 9576 
                 5.001 
                 2.36E−05 
                 2.95E−06 
                 0.0011434 
               
               
                   
                 CC_ALL 
                 matrix 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0001525~angiogenesis 
                 17 
                 4.94 
                 4.00E−08 
                 291 
                 91 
                 8731 
                 5.605 
                 8.73E−05 
                 3.97E−06 
                 6.95E−05 
               
               
                   
                 BP_ALL 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0051707~response 
                 22 
                 6.40 
                 5.14E−08 
                 291 
                 158 
                 8731 
                 4.178 
                 0.00011219 
                 4.88E−06 
                 8.92E−05 
               
               
                   
                 BP_ALL 
                 to other organism 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0016477~cell 
                 22 
                 6.40 
                 6.42E−08 
                 291 
                 160 
                 8731 
                 4.125 
                 0.00014011 
                 5.84E−06 
                 0.00011144 
               
               
                   
                 BP_ALL 
                 migration 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0016020~membrane 
                 169 
                 49.13 
                 1.96E−07 
                 305 
                 3915 
                 9576 
                 1.355 
                 5.33E−05 
                 5.93E−06 
                 0.00025814 
               
               
                   
                 CC_ALL 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 KEGG —   
                 hsa04060: Cytokine- 
                 19 
                 5.52 
                 8.99E−08 
                 123 
                 109 
                 3163 
                 4.483 
                 9.53E−06 
                 9.53E−06 
                 0.00010084 
               
               
                   
                 PATHWAY 
                 cytokine receptor 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 interaction 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0009653~anatomical 
                 50 
                 14.53 
                 1.18E−07 
                 291 
                 675 
                 8731 
                 2.222 
                 0.00025871 
                 9.58E−06 
                 0.00020578 
               
               
                   
                 BP_ALL 
                 structure morphogenesis 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0042221~response 
                 56 
                 16.28 
                 1.17E−07 
                 291 
                 802 
                 8731 
                 2.095 
                 0.00025627 
                 9.86E−06 
                 0.00020384 
               
               
                   
                 BP_ALL 
                 to chemical stimulus 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0010033~response 
                 39 
                 11.34 
                 1.26E−07 
                 291 
                 457 
                 8731 
                 2.560 
                 0.0002761 
                 9.86E−06 
                 0.00021962 
               
               
                   
                 BP_ALL 
                 to organic substance 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0048513~organ 
                 62 
                 18.02 
                 1.13E−07 
                 291 
                 532 
                 8731 
                 1.996 
                 0.00024675 
                 9.87E−06 
                 0.00019627 
               
               
                   
                 BP_ALL 
                 development 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0048519~negative 
                 74 
                 21.51 
                 1.50E−07 
                 291 
                 1214 
                 8731 
                 1.829 
                 0.00032738 
                 1.13E−05 
                 0.00026041 
               
               
                   
                 BP_ALL 
                 regulation of biological 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 process 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0032101~regulation 
                 15 
                 4.36 
                 1.86E−07 
                 291 
                 77 
                 8731 
                 5.845 
                 0.00040597 
                 1.35E−05 
                 0.00032294 
               
               
                   
                 BP_ALL 
                 of response to 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 external stimulus 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0065008~regulation 
                 57 
                 16.57 
                 1.97E−07 
                 291 
                 836 
                 8731 
                 2.046 
                 0.00042941 
                 1.39E−05 
                 0.0003416 
               
               
                   
                 BP_ALL 
                 of biological quality 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0005578~proteinaceous 
                 16 
                 4.65 
                 5.27E−07 
                 305 
                 100 
                 9576 
                 5.023 
                 0.00014321 
                 1.43E−05 
                 0.00069309 
               
               
                   
                 CC_ALL 
                 extracellular matrix 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0048646~anatomical 
                 25 
                 7.27 
                 2.19E−07 
                 291 
                 218 
                 8731 
                 3.441 
                 0.00047903 
                 1.50E−05 
                 0.00038107 
               
               
                   
                 BP_ALL 
                 structure formation 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 involved in 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 morphogenesis 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0048870~cell 
                 22 
                 6.40 
                 2.49E−07 
                 291 
                 173 
                 8731 
                 3.815 
                 0.00054426 
                 1.65E−05 
                 0.00043298 
               
               
                   
                 BP_ALL 
                 motility 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0051674~localization 
                 22 
                 6.40 
                 2.49E−07 
                 291 
                 173 
                 8731 
                 3.815 
                 0.00054426 
                 1.65E−05 
                 0.00043298 
               
               
                   
                 BP_ALL 
                 of cell 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0051094~positive 
                 22 
                 5.40 
                 2.75E−07 
                 291 
                 174 
                 8731 
                 3.794 
                 0.00060061 
                 1.77E−05 
                 0.00047782 
               
               
                   
                 BP_ALL 
                 regulation of 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 developmental process 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0031224~intrinsic 
                 123 
                 35.76 
                 1.13E−06 
                 305 
                 2645 
                 9576 
                 1.460 
                 0.00030837 
                 2.80E−05 
                 0.00149255 
               
               
                   
                 CC_ALL 
                 to membrane 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0030154~cell 
                 58 
                 16.86 
                 5.18E−07 
                 291 
                 883 
                 8731 
                 1.971 
                 0.00113121 
                 3.23E−05 
                 0.00090018 
               
               
                   
                 BP_ALL 
                 differentiation 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0007166~cell 
                 48 
                 13.35 
                 5.38E−07 
                 291 
                 667 
                 8731 
                 2.159 
                 0.00117393 
                 3.26E−05 
                 0.0009342 
               
               
                   
                 BP_ALL 
                 surface receptor linked 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 signal transduction 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0019955~cytokine 
                 13 
                 3.78 
                 3.43E−07 
                 297 
                 61 
                 9375 
                 6.727 
                 0.00020278 
                 5.07E−05 
                 0.00050503 
               
               
                   
                 MF_ALL 
                 binding 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0042060~wound 
                 16 
                 4.65 
                 9.16E−07 
                 291 
                 100 
                 8731 
                 4.801 
                 0.00199804 
                 5.41E−05 
                 0.00159067 
               
               
                   
                 BP_ALL 
                 healing 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0006928~cell 
                 27 
                 7.85 
                 1.17E−06 
                 291 
                 273 
                 8731 
                 2.967 
                 0.00254332 
                 6.70E−05 
                 0.00202532 
               
               
                   
                 BP_ALL 
                 motion 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0022603~regulation 
                 18 
                 5.23 
                 1.40E−06 
                 291 
                 131 
                 8731 
                 4.123 
                 0.00305304 
                 7.84E−05 
                 0.00243184 
               
               
                   
                 BP_ALL 
                 of anatomical 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 structure morphogenesis 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0048518~positive 
                 76 
                 22.09 
                 1.48E−06 
                 291 
                 1335 
                 8731 
                 1.708 
                 0.00323049 
                 7.89E−05 
                 0.00257341 
               
               
                   
                 BP_ALL 
                 regulation of 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 biological process 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0045597~positive 
                 19 
                 5.52 
                 1.46E−06 
                 291 
                 146 
                 8731 
                 3.905 
                 0.00318974 
                 7.99E−05 
                 0.0025409 
               
               
                   
                 BP_ALL 
                 regulation of cell 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 differentiation 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0048869~cellular 
                 59 
                 17.15 
                 1.61E−06 
                 291 
                 937 
                 8731 
                 1.889 
                 0.00351577 
                 8.39E−05 
                 0.00280106 
               
               
                   
                 BP_ALL 
                 developmental process 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0045595~regulation 
                 28 
                 8.14 
                 1.90E−06 
                 291 
                 298 
                 8731 
                 2.819 
                 0.00413858 
                 9.64E−05 
                 0.00329828 
               
               
                   
                 BP_ALL 
                 of cell differentiation 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0065007~biological 
                 189 
                 54.94 
                 2.27E−06 
                 291 
                 4499 
                 8731 
                 1.260 
                 0.00493883 
                 0.00011252 
                 0.00393762 
               
               
                   
                 BP_ALL 
                 regulation 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0009607~response 
                 24 
                 6.98 
                 2.33E−06 
                 291 
                 231 
                 8731 
                 3.117 
                 0.00508171 
                 0.00011321 
                 0.00405183 
               
               
                   
                 BP_ALL 
                 to biotic stimulus 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0016021~integral 
                 117 
                 34.01 
                 7.05E−06 
                 305 
                 2564 
                 9576 
                 1.433 
                 0.00191674 
                 0.00015987 
                 0.00928437 
               
               
                   
                 CC_ALL 
                 to membrane 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0050789~regulation 
                 181 
                 52.62 
                 6.79E−06 
                 291 
                 4312 
                 8731 
                 1.259 
                 0.01472889 
                 0.00032252 
                 0.01180067 
               
               
                   
                 BP_ALL 
                 of biological process 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0051384~response 
                 10 
                 2.91 
                 7.38E−06 
                 291 
                 42 
                 8731 
                 7.144 
                 0.01599922 
                 0.0003431 
                 0.01282663 
               
               
                   
                 BP_ALL 
                 to glucocorticoid stimulus 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0002682~regulation 
                 23 
                 6.69 
                 1.05E−05 
                 291 
                 235 
                 8731 
                 2.937 
                 0.02269405 
                 0.00047813 
                 0.01825541 
               
               
                   
                 BP_ALL 
                 of immune system process 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0031960~response 
                 10 
                 2.91 
                 1.11E−05 
                 291 
                 44 
                 8731 
                 6.819 
                 0.02389824 
                 0.00049352 
                 0.01923579 
               
               
                   
                 BP_ALL 
                 to corticosteroid stimulus 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0007610~behavior 
                 22 
                 6.40 
                 1.34E−05 
                 291 
                 221 
                 8731 
                 2.987 
                 0.02894023 
                 0.00058717 
                 0.02335375 
               
               
                   
                 BP_ALL 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0009617~response 
                 14 
                 4.07 
                 1.39E−05 
                 291 
                 95 
                 8731 
                 4.422 
                 0.02982868 
                 0.0005936 
                 0.02408158 
               
               
                   
                 BP_ALL 
                 to bacterium 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0007626~locomotory 
                 17 
                 4.94 
                 1.51E−05 
                 291 
                 140 
                 8731 
                 3.643 
                 0.03243116 
                 0.00063381 
                 0.02621736 
               
               
                   
                 BP_ALL 
                 behavior 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0048523~negative 
                 64 
                 18.60 
                 1.57E−05 
                 291 
                 1127 
                 8731 
                 1.704 
                 0.03368346 
                 0.00064628 
                 0.02724712 
               
               
                   
                 BP_ALL 
                 regulation of 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 cellular process 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0043627~response 
                 11 
                 3.20 
                 2.08E−05 
                 291 
                 59 
                 8731 
                 5.594 
                 0.04438121 
                 0.00084032 
                 0.03609816 
               
               
                   
                 BP_ALL 
                 to estrogen stimulus 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0048878~chemical 
                 23 
                 6.69 
                 2.33E−05 
                 291 
                 247 
                 8731 
                 2.794 
                 0.0495174 
                 0.00092295 
                 0.0403827 
               
               
                   
                 BP_ALL 
                 homeostasis 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0019838~growth 
                 11 
                 3.20 
                 8.31E−05 
                 297 
                 56 
                 9375 
                 6.200 
                 0.0049076 
                 0.00098345 
                 0.01225035 
               
               
                   
                 MF_ALL 
                 factor binding 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0070482~response 
                 13 
                 3.78 
                 2.74E−05 
                 291 
                 87 
                 8731 
                 4.483 
                 0.05817137 
                 0.00106964 
                 0.04765395 
               
               
                   
                 BP_ALL 
                 to oxygen levels 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0000262~cell 
                 41 
                 11.92 
                 5.68E−05 
                 305 
                 662 
                 9576 
                 1.945 
                 0.01533071 
                 0.00118767 
                 0.07473585 
               
               
                   
                 CC_ALL 
                 fraction 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0005626~insoluble 
                 34 
                 9.88 
                 6.61E−05 
                 305 
                 508 
                 9576 
                 2.101 
                 0.017809867 
                 0.00128276 
                 0.08692732 
               
               
                   
                 CC_ALL 
                 fraction 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0006935~chemotaxis 
                 13 
                 3.78 
                 3.46E−05 
                 291 
                 89 
                 8731 
                 4.383 
                 0.07280814 
                 0.00132535 
                 0.06020426 
               
               
                   
                 BP_ALL 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0042330~taxis 
                 13 
                 3.78 
                 3.46E−05 
                 291 
                 89 
                 8731 
                 4.383 
                 0.07280814 
                 0.00132535 
                 0.06010426 
               
               
                   
                 BP_ALL 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0009968~negative 
                 16 
                 4.65 
                 3.90E−05 
                 291 
                 135 
                 8731 
                 3.556 
                 0.08171162 
                 0.00146864 
                 0.06777345 
               
               
                   
                 BP_ALL 
                 regulation of signal 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0014070~response 
                 12 
                 3.49 
                 4.26E−05 
                 291 
                 77 
                 8731 
                 4.676 
                 0.0888131 
                 0.00152355 
                 0.07394353 
               
               
                   
                 BP_ALL 
                 to organic cyclic 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 substance 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0007165~signal 
                 74 
                 21.51 
                 4.14E−05 
                 291 
                 1411 
                 8731 
                 1.574 
                 0.08646755 
                 0.00153165 
                 0.07190035 
               
               
                   
                 BP_ALL 
                 transduction 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0048584~positive 
                 16 
                 4.65 
                 4.26E−05 
                 291 
                 136 
                 8731 
                 3.530 
                 0.08879912 
                 0.00154866 
                 0.07393134 
               
               
                   
                 BP_ALL 
                 regulation of 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 response to 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 stimulus 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0009719~response 
                 22 
                 6.40 
                 5.26E−05 
                 291 
                 242 
                 8731 
                 2.728 
                 0.10344839 
                 0.00184978 
                 0.09125557 
               
               
                   
                 BP_ALL 
                 to endogenous stimulus 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0045765~regulation 
                 8 
                 2.33 
                 6.83E−05 
                 291 
                 32 
                 8731 
                 7.501 
                 0.1386353 
                 0.00236604 
                 0.11862156 
               
               
                   
                 BP_ALL 
                 of angiogenesis 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0009991~response 
                 16 
                 4.65 
                 7.04E−05 
                 291 
                 142 
                 8731 
                 3.381 
                 0.14260665 
                 0.00240115 
                 0.12229249 
               
               
                   
                 BP_ALL 
                 to extracellular 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 stimulus 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0048522~positive 
                 66 
                 19.19 
                 7.28E−05 
                 291 
                 1234 
                 8731 
                 1.605 
                 0.14701919 
                 0.00244344 
                 0.12639105 
               
               
                   
                 BP_ALL 
                 regulation of 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 cellular process 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0005624~membrane 
                 32 
                 9.30 
                 0.0001466 
                 305 
                 484 
                 9576 
                 2.076 
                 0.03909456 
                 0.00265509 
                 0.19280628 
               
               
                   
                 CC_ALL 
                 fraction 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0044425~membrane 
                 140 
                 40.70 
                 0.00016676 
                 305 
                 3420 
                 9576 
                 1.285 
                 0.04435026 
                 0.00283122 
                 0.21929353 
               
               
                   
                 CC_ALL 
                 part 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0001666~response 
                 12 
                 3.49 
                 8.62E−05 
                 291 
                 83 
                 8731 
                 4.338 
                 0.17161099 
                 0.00284855 
                 0.14962549 
               
               
                   
                 BP_ALL 
                 to hypoxia 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0050776~regulation 
                 15 
                 4.36 
                 9.15E−05 
                 291 
                 123 
                 8731 
                 3.489 
                 0.18106373 
                 0.00297689 
                 0.15873903 
               
               
                   
                 BP_ALL 
                 of immune response 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0010648~negative 
                 16 
                 4.65 
                 9.69E−05 
                 291 
                 146 
                 8731 
                 3.288 
                 0.19077735 
                 0.00306314 
                 0.16821347 
               
               
                   
                 BP_ALL 
                 regulation of cell 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 communication 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0048585~negative 
                 10 
                 2.91 
                 9.62E−05 
                 291 
                 57 
                 8731 
                 5.264 
                 0.19954902 
                 0.00308588 
                 0.16700917 
               
               
                   
                 BP_ALL 
                 regulation of response 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 to stimulus 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0031099~regeneration 
                 8 
                 2.33 
                 0.00010316 
                 291 
                 34 
                 8731 
                 7.060 
                 0.20173321 
                 0.00321357 
                 0.17903588 
               
               
                   
                 BP_ALL 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0009725~response 
                 20 
                 5.81 
                 0.0001064 
                 291 
                 217 
                 8731 
                 2.765 
                 0.20736027 
                 0.0032677 
                 0.18465182 
               
               
                   
                 BP_ALL 
                 to hormone stimulus 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0050801~ion 
                 19 
                 5.52 
                 0.00011383 
                 291 
                 200 
                 8731 
                 2.850 
                 0.22011692 
                 0.00344698 
                 0.19753113 
               
               
                   
                 BP_ALL 
                 homeostasis 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0007155~cell 
                 26 
                 7.56 
                 0.00011726 
                 291 
                 334 
                 8731 
                 2.336 
                 0.22594061 
                 0.00350216 
                 0.20348045 
               
               
                   
                 BP_ALL 
                 adhesion 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0022610~biological 
                 26 
                 7.56 
                 0.00012311 
                 291 
                 335 
                 8731 
                 2.329 
                 0.23576926 
                 0.00362699 
                 0.21362257 
               
               
                   
                 BP_ALL 
                 adhesion 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0006873~cellular 
                 18 
                 5.23 
                 0.00016537 
                 291 
                 163 
                 8731 
                 2.873 
                 0.30315535 
                 0.00480433 
                 0.28685303 
               
               
                   
                 BP_ALL 
                 ion homeostasis 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0055082~cellular 
                 18 
                 5.23 
                 0.00017635 
                 291 
                 189 
                 8731 
                 2.857 
                 0.31967946 
                 0.00505548 
                 0.30588293 
               
               
                   
                 BP_ALL 
                 chemical homeostatis 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0002684~positive 
                 15 
                 4.36 
                 0.00018897 
                 291 
                 138 
                 8731 
                 3.261 
                 0.33816687 
                 0.00534594 
                 0.32772523 
               
               
                   
                 BP_ALL 
                 regulation of immune 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 system process 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0002703~regulation 
                 8 
                 2.33 
                 0.00021596 
                 291 
                 38 
                 8731 
                 6.317 
                 0.37607009 
                 0.00595331 
                 0.37446511 
               
               
                   
                 BP_ALL 
                 of leukocyte 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 mediated immunity 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0032496~response 
                 9 
                 2.62 
                 0.00021432 
                 291 
                 50 
                 8731 
                 5.401 
                 0.37382152 
                 0.00598356 
                 0.37161469 
               
               
                   
                 BP_ALL 
                 to lipopolysaccharide 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 KEGG —   
                 hsa04640: Hematopoietic 
                 9 
                 2.62 
                 0.00012756 
                 123 
                 41 
                 3163 
                 5.645 
                 0.01343153 
                 0.00673847 
                 0.14304552 
               
               
                   
                 PATHWAY 
                 cell lineage 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0002822~regulation 
                 8 
                 2.33 
                 0.00025583 
                 291 
                 39 
                 8731 
                 6.155 
                 0.42810616 
                 0.00696069 
                 0.44344237 
               
               
                   
                 BP_ALL 
                 of adaptive immune 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 response based on 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 somatic recombination 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 of immune receptors 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 built from 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 immunoglobulin 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 superfamily domains 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0051704~multi- 
                 30 
                 8.72 
                 0.00026472 
                 291 
                 436 
                 8731 
                 2.064 
                 0.43910546 
                 0.00711313 
                 0.45881825 
               
               
                   
                 BP_ALL 
                 organism process 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0003008~system 
                 31 
                 9.01 
                 0.00029081 
                 291 
                 460 
                 8731 
                 2.022 
                 0.47018397 
                 0.00771672 
                 0.50393593 
               
               
                   
                 BP_ALL 
                 process 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0050794~regulation 
                 168 
                 48.84 
                 0.00029607 
                 291 
                 4148 
                 8731 
                 1.215 
                 0.47623627 
                 0.00776147 
                 0.51302706 
               
               
                   
                 BP_ALL 
                 of cellular process 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0002819~regulation 
                 8 
                 2.33 
                 0.00030141 
                 291 
                 40 
                 8731 
                 6.001 
                 0.48230732 
                 0.00780714 
                 0.52225166 
               
               
                   
                 BP_ALL 
                 of adaptive 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 immune response 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0031225~anchored 
                 11 
                 3.20 
                 0.00049512 
                 305 
                 89 
                 9576 
                 3.880 
                 0.12602806 
                 0.00789263 
                 0.64978292 
               
               
                   
                 CC_ALL 
                 to membrane 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0042592~homeostatic 
                 29 
                 8.43 
                 0.00036654 
                 291 
                 423 
                 8731 
                 2.057 
                 0.55097816 
                 0.00937553 
                 0.63477609 
               
               
                   
                 BP_ALL 
                 process 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0015718~monocarboxylic 
                 7 
                 2.03 
                 0.00038604 
                 291 
                 30 
                 8731 
                 7.001 
                 0.56969876 
                 0.00975755 
                 0.66842859 
               
               
                   
                 BP_ALL 
                 acid transport 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0040012~regulation 
                 13 
                 3.78 
                 0.00041686 
                 291 
                 115 
                 8731 
                 3.392 
                 0.59772396 
                 0.01041227 
                 0.72161898 
               
               
                   
                 BP_ALL 
                 of locomotion 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0006357~regulation 
                 32 
                 9.30 
                 0.00043124 
                 291 
                 493 
                 8731 
                 1.947 
                 0.61016879 
                 0.01064792 
                 0.74642831 
               
               
                   
                 BP_ALL 
                 of transcription 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 from RNA polymerase II 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 promoter 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0031328~positive 
                 29 
                 8.43 
                 0.00050989 
                 291 
                 432 
                 8731 
                 2.014 
                 0.67171554 
                 0.01243745 
                 0.88197876 
               
               
                   
                 BP_ALL 
                 regulation of cellular 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 biosynthetic process 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0050878~regulation 
                 10 
                 2.91 
                 0.00053053 
                 291 
                 71 
                 8731 
                 4.226 
                 0.68619313 
                 0.01279497 
                 0.91752731 
               
               
                   
                 BP_ALL 
                 of body fluid 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0010876~lipid 
                 12 
                 3.49 
                 0.00054417 
                 291 
                 102 
                 8731 
                 3.530 
                 0.69540799 
                 0.01297858 
                 0.94101129 
               
               
                   
                 BP_ALL 
                 localization 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0050865~regulation 
                 12 
                 3.49 
                 0.00059161 
                 291 
                 103 
                 8731 
                 3.496 
                 0.72540716 
                 0.01395032 
                 1.02266381 
               
               
                   
                 BP_ALL 
                 of cell activation 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0002237~response 
                 9 
                 2.62 
                 0.00060803 
                 291 
                 58 
                 8731 
                 4.656 
                 0.73508127 
                 0.01418162 
                 1.05089343 
               
               
                   
                 BP_ALL 
                 to molecule of 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 bacterial origin 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0030247~polysaccharide 
                 10 
                 2.91 
                 0.00014598 
                 297 
                 63 
                 9375 
                 5.010 
                 0.08279861 
                 0.01430145 
                 0.21499395 
               
               
                   
                 MF_ALL 
                 binding 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0001871~pattern 
                 10 
                 2.91 
                 0.00014598 
                 297 
                 63 
                 9375 
                 5.010 
                 0.08279861 
                 0.01430145 
                 0.21499395 
               
               
                   
                 MF_ALL 
                 binding 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0042127~regulation 
                 31 
                 9.01 
                 0.00063941 
                 291 
                 482 
                 8731 
                 1.930 
                 0.75264313 
                 0.01475101 
                 1.10485745 
               
               
                   
                 BP_ALL 
                 of cell proliferation 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0009891~positive 
                 29 
                 8.43 
                 0.00066254 
                 291 
                 439 
                 8731 
                 1.982 
                 0.76483615 
                 0.01512107 
                 1.14460859 
               
               
                   
                 BP_ALL 
                 regulation of 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 biosynthetic 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 process 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0044057~regulation 
                 14 
                 4.07 
                 0.00075021 
                 291 
                 140 
                 8731 
                 3.000 
                 0.80584037 
                 0.01692876 
                 1.29513516 
               
               
                   
                 BP_ALL 
                 of system process 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0002697~regulation 
                 9 
                 2.62 
                 0.00076637 
                 291 
                 60 
                 8731 
                 4.501 
                 0.81257953 
                 0.01711373 
                 1.32286309 
               
               
                   
                 BP_ALL 
                 of immune effector 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0046983~protein 
                 26 
                 7.56 
                 0.00020881 
                 297 
                 364 
                 9375 
                 2.255 
                 0.11628999 
                 0.01750586 
                 0.30738349 
               
               
                   
                 MF_ALL 
                 dimerization activity 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0051270~regulation 
                 13 
                 3.78 
                 0.00088686 
                 291 
                 125 
                 8731 
                 3.120 
                 0.8559733 
                 0.01957882 
                 1.52932924 
               
               
                   
                 BP_ALL 
                 of cell motion 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0007167~enzyme 
                 17 
                 4.94 
                 0.00094775 
                 291 
                 199 
                 8731 
                 2.563 
                 0.87392438 
                 0.02070065 
                 1.63352589 
               
               
                   
                 BP_ALL 
                 linked receptor 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 protein signaling 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 pathway 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0009986~cell 
                 15 
                 4.36 
                 0.00141943 
                 305 
                 176 
                 9576 
                 2.676 
                 0.3204743 
                 0.02123574 
                 1.85238613 
               
               
                   
                 CC_ALL 
                 surface 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0019725~cellular 
                 20 
                 5.81 
                 0.0009974 
                 291 
                 259 
                 8731 
                 2.317 
                 0.88689134 
                 0.02155829 
                 1.71839807 
               
               
                   
                 BP_ALL 
                 homeostasis 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0009966~regulation 
                 35 
                 10.17 
                 0.00102968 
                 291 
                 588 
                 8731 
                 1.786 
                 0.89459753 
                 0.02203062 
                 1.7735386 
               
               
                   
                 BP_ALL 
                 of signal transduction 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0032879~regulation 
                 24 
                 6.98 
                 0.00107922 
                 291 
                 344 
                 8731 
                 2.093 
                 0.90541806 
                 0.02242069 
                 1.85812337 
               
               
                   
                 BP_ALL 
                 of localization 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0002683~negative 
                 8 
                 2.33 
                 0.001076 
                 291 
                 49 
                 8731 
                 4.899 
                 0.90474892 
                 0.02256898 
                 1.85262047 
               
               
                   
                 BP_ALL 
                 regulation of 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 immune system process 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0006869~lipid 
                 11 
                 3.20 
                 0.00107471 
                 291 
                 94 
                 8731 
                 3.511 
                 0.90448101 
                 0.0227608 
                 1.85042799 
               
               
                   
                 BP_ALL 
                 transport 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0007399~nervous 
                 34 
                 9.88 
                 0.00117602 
                 291 
                 569 
                 8731 
                 1.793 
                 0.92345953 
                 0.02395313 
                 2.02318447 
               
               
                   
                 BP_ALL 
                 system development 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0007154~cell 
                 24 
                 6.98 
                 0.00116651 
                 291 
                 346 
                 8731 
                 2.081 
                 0.92185199 
                 0.02398529 
                 2.0069868 
               
               
                   
                 BP_ALL 
                 communication 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0001570~vasculogenesis 
                 6 
                 1.74 
                 0.00120076 
                 291 
                 25 
                 8731 
                 7.201 
                 0.9274906 
                 0.02422547 
                 2.06533461 
               
               
                   
                 BP_ALL 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0008284~positive 
                 19 
                 5.52 
                 0.00126607 
                 291 
                 244 
                 8731 
                 2.136 
                 0.93714055 
                 0.02529364 
                 2.17650973 
               
               
                   
                 BP_ALL 
                 regulation of 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 cell proliferation 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0008285~negative 
                 18 
                 5.23 
                 0.00132516 
                 291 
                 225 
                 8731 
                 2.400 
                 0.94475993 
                 0.02575327 
                 2.2769872 
               
               
                   
                 BP_ALL 
                 regulation of 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 cell proliferation 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0042981~regulation 
                 35 
                 10.17 
                 0.00131483 
                 291 
                 596 
                 8731 
                 1.762 
                 0.94349817 
                 0.02578432 
                 2.25943273 
               
               
                   
                 BP_ALL 
                 of apoptosis 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0002696~positive 
                 9 
                 2.62 
                 0.00131011 
                 291 
                 65 
                 8731 
                 4.154 
                 0.94291175 
                 0.02592551 
                 2.25140603 
               
               
                   
                 BP_ALL 
                 regulation of 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 leukocyte 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 activation 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM 
                 GO:0002694~regulation 
                 11 
                 3.20 
                 0.00136994 
                 291 
                 97 
                 8731 
                 3.402 
                 0.9499138 
                 0.02637809 
                 2.35308046 
               
               
                   
                 BP_ALL 
                 of leukocyte 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 activation 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0008360~regulation 
                 7 
                 2.03 
                 0.00143618 
                 291 
                 38 
                 8731 
                 5.527 
                 0.95666858 
                 0.02739544 
                 2.4655229 
               
               
                   
                 BP_ALL 
                 of cell shape 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0051173~positive 
                 27 
                 7.85 
                 0.00152867 
                 291 
                 419 
                 8731 
                 1.933 
                 0.96460461 
                 0.02863568 
                 2.62231934 
               
               
                   
                 BP_ALL 
                 regulation of 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 nitrogen compound 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 metabolic process 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0043067~regulation 
                 35 
                 10.17 
                 0.00151875 
                 291 
                 602 
                 8731 
                 1.744 
                 0.96382789 
                 0.02869828 
                 2.6055065 
               
               
                   
                 BP_ALL 
                 of programmed cell death 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0010941~regulation 
                 35 
                 10.17 
                 0.00162481 
                 291 
                 604 
                 8731 
                 1.739 
                 0.97131776 
                 0.03015225 
                 2.78505643 
               
               
                   
                 BP_ALL 
                 of cell death 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0050727~regulation 
                 7 
                 2.03 
                 0.00165079 
                 291 
                 39 
                 8731 
                 5.385 
                 0.97290246 
                 0.03036957 
                 2.82898994 
               
               
                   
                 BP_ALL 
                 of inflammatory 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0050930~induction 
                 4 
                 1.16 
                 0.00179385 
                 291 
                 8 
                 8731 
                 15.002 
                 0.98018432 
                 0.03268511 
                 3.07055936 
               
               
                   
                 BP_ALL 
                 of positive chemotaxis 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0010646~regulation 
                 37 
                 10.76 
                 0.00194382 
                 291 
                 658 
                 8731 
                 1.687 
                 0.98572763 
                 0.03450973 
                 3.32320019 
               
               
                   
                 BP_ALL 
                 of cell communication 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0050867~positive 
                 9 
                 2.62 
                 0.0019358 
                 291 
                 69 
                 8731 
                 3.913 
                 0.98547495 
                 0.03465108 
                 3.30970571 
               
               
                   
                 BP_ALL 
                 regulation of 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 cell activation 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0080134~regulation 
                 15 
                 4.36 
                 0.00192655 
                 291 
                 174 
                 8731 
                 2.587 
                 0.98517793 
                 0.03477294 
                 3.29413758 
               
               
                   
                 BP_ALL 
                 of response to stress 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0001501~skeletal 
                 14 
                 4.07 
                 0.00202877 
                 291 
                 156 
                 8731 
                 2.693 
                 0.98814896 
                 0.03570233 
                 3.46603944 
               
               
                   
                 BP_ALL 
                 system development 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0009615~response 
                 9 
                 2.62 
                 0.00212404 
                 291 
                 70 
                 8731 
                 3.858 
                 0.99037937 
                 0.03705101 
                 3.62598828 
               
               
                   
                 BP_ALL 
                 to virus 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0009888~tissue 
                 22 
                 6.40 
                 0.00215578 
                 291 
                 319 
                 8731 
                 2.069 
                 0.99102486 
                 0.03729713 
                 3.67920761 
               
               
                   
                 BP_ALL 
                 development 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0055066~di, 
                 12 
                 3.49 
                 0.00223579 
                 291 
                 121 
                 8731 
                 2.976 
                 0.9924667 
                 0.03835256 
                 3.81327117 
               
               
                   
                 BP_ALL 
                 tri-valent inorganic 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 cation homeostasis 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0022604~regulation 
                 10 
                 2.91 
                 0.00230132 
                 291 
                 87 
                 8731 
                 3.449 
                 0.99347346 
                 0.03914863 
                 3.92295161 
               
               
                   
                 BP_ALL 
                 of cell morphogenesis 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0042493~response 
                 13 
                 3.78 
                 0.00236067 
                 291 
                 140 
                 8731 
                 2.786 
                 0.99426863 
                 0.03952428 
                 4.02217244 
               
               
                   
                 BP_ALL 
                 to drug 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0035295~tube 
                 12 
                 3.49 
                 0.00238661 
                 291 
                 122 
                 8731 
                 2.951 
                 0.99458499 
                 0.03964677 
                 4.06550921 
               
               
                   
                 BP_ALL 
                 development 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0043066~negative 
                 19 
                 5.52 
                 0.0023525 
                 291 
                 258 
                 8731 
                 2.210 
                 0.99416515 
                 0.03969391 
                 4.0085168 
               
               
                   
                 BP_ALL 
                 regulation of apoptosis 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0005125~cytokine 
                 9 
                 2.62 
                 0.00055115 
                 297 
                 60 
                 9375 
                 4.735 
                 0.27846423 
                 0.03997568 
                 0.80944805 
               
               
                   
                 MF_ALL 
                 activity 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0048146~positive 
                 5 
                 1.45 
                 0.00252304 
                 291 
                 18 
                 8731 
                 8.334 
                 0.99598326 
                 0.04155265 
                 4.2931463 
               
               
                   
                 BP_ALL 
                 regulation of 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0044420~extracellular 
                 7 
                 2.03 
                 0.00313139 
                 305 
                 46 
                 9576 
                 4.778 
                 0.57389694 
                 0.04175683 
                 4.04432272 
               
               
                   
                 CC_ALL 
                 matrix part 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 KEGG —   
                 hsa04610: Complement 
                 6 
                 1.74 
                 0.00122148 
                 123 
                 22 
                 3163 
                 7.013 
                 0.12151451 
                 0.04226609 
                 1.36209977 
               
               
                   
                 PATHWAY 
                 and coagulation cascades 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0005604~basment 
                 6 
                 1.74 
                 0.00310557 
                 305 
                 32 
                 9576 
                 5.887 
                 0.57088513 
                 0.04355111 
                 4.01160983 
               
               
                   
                 CC_ALL 
                 membrane 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0043069~negative 
                 19 
                 5.52 
                 0.00267451 
                 291 
                 261 
                 8731 
                 2.184 
                 0.99711711 
                 0.04366649 
                 4.5452809 
               
               
                   
                 BP_ALL 
                 regulation of 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 programmed cell death 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0060548~negative 
                 19 
                 5.52 
                 0.00277099 
                 291 
                 262 
                 8731 
                 2.176 
                 0.99766616 
                 0.04487296 
                 4.70554415 
               
               
                   
                 BP_ALL 
                 regulation of cell death 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0050671~positive 
                 6 
                 1.74 
                 0.00281214 
                 291 
                 30 
                 8731 
                 6.001 
                 0.9978673 
                 0.04519043 
                 4.77382529 
               
               
                   
                 BP_ALL 
                 regulation of lymphocyte 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 proliferation 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0070665~positive 
                 6 
                 1.74 
                 0.00281214 
                 291 
                 30 
                 8731 
                 6.001 
                 0.9978673 
                 0.04519043 
                 4.77382529 
               
               
                   
                 BP_ALL 
                 regulation of leukocyte 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 proliferation 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0032946~positive 
                 6 
                 1.74 
                 0.00281214 
                 291 
                 30 
                 8731 
                 6.001 
                 0.9978673 
                 0.04519043 
                 4.77382529 
               
               
                   
                 BP_ALL 
                 regulation of mononuclear 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 cell proliferation 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0030141~secretory 
                 10 
                 2.91 
                 0.00359451 
                 305 
                 97 
                 9576 
                 3.237 
                 0.62448874 
                 0.04557029 
                 4.62946073 
               
               
                   
                 CC_ALL 
                 granule 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0010628~positive 
                 24 
                 6.98 
                 0.00297411 
                 291 
                 372 
                 8731 
                 1.936 
                 0.99850427 
                 0.04704368 
                 5.04213471 
               
               
                   
                 BP_ALL 
                 regulation of gene expression 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0010557~positive 
                 26 
                 7.56 
                 0.00295976 
                 291 
                 417 
                 8731 
                 1.871 
                 0.99845649 
                 0.04716276 
                 5.01838762 
               
               
                   
                 BP_ALL 
                 regulation of macromolecule 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 biosynthetic process 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0051241~negative 
                 9 
                 2.62 
                 0.00302532 
                 291 
                 74 
                 8731 
                 3.649 
                 0.99866299 
                 0.04749198 
                 5.12681765 
               
               
                   
                 BP_ALL 
                 regulation of multicellular 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 organismal 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 process 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0007204~elevation 
                 7 
                 2.03 
                 0.00310921 
                 291 
                 44 
                 8731 
                 4.773 
                 0.99888743 
                 0.04843088 
                 5.26537775 
               
               
                   
                 BP_ALL 
                 of cytosolic calcium ion 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                   
                 concentration 
                   
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 GOTERM —   
                 GO:0001503~ossification 
                 8 
                 2.33 
                 0.00322266 
                 291 
                 59 
                 8731 
                 4.068 
                 0.99913229 
                 0.04980154 
                 5.45247258 
               
               
                   
                 BP_ALL 
               
               
                   
               
             
          
           
               
                   
                 Category 
                 Genes 
               
               
                   
               
               
                   
                 GOTERM —   
                 210495_X_AT, 229221_AT, 223723_AT, 210136_AT, 212298_AT, 209555_S_AT, 212014_X_AT, 
               
               
                   
                 CC_ALL 
                 216834_AT, 203923_S_AT, 211066_X_AT, 210916_S_AT, 216971_S_AT, 219412_AT, 207674_AT, 
               
               
                   
                   
                 202828_S_AT, 230360_AT, 236561_AT, 226545_AT, 201925_AT, 217173_S_AT, 204489_S_AT, 
               
               
                   
                   
                 207610_S_AT, 220307_AT, 212099_AT, 211307_S_AT, 223303_AT, 201590_X_AT, 232549_AT, 
               
               
                   
                   
                 203922_S_AT, 229937_X_AT, 214830_AT, 1552914_A_AT, 203104_AT, 212977_AT, 202756_S_AT, 
               
               
                   
                   
                 228766_AT, 203508_AT, 230925_AT, 210845_S_AT, 243556_AT, 206033_S_AT, 201005_AT, 
               
               
                   
                   
                 201242_S_AT, 233220_AT, 242907_AT, 207819_S_AT, 224678_AT, 209122_AT, 214211_AT, 
               
               
                   
                   
                 217252_AT, 160020_AT, 208926_AT, 214297_AT, 210233_AT, 218910_AT, 211719_X_AT, 209949_AT, 
               
               
                   
                   
                 214866_AT, 223501_AT, 205534_AT, 34210_AT, 205099_S_AT, 209994_S_AT, 1557905_S_AT, 
               
               
                   
                   
                 228754_AT, 209670_AT, 238542_AT, 215836_S_AT, 217678_AT, 205717_X_AT, 217078_S_AT, 
               
               
                   
                   
                 209047_AT, 238581_AT, 201739_AT, 1554992_AT, 209906_AT, 221840_AT, 211030_S_AT, 205920_AT, 
               
               
                   
                   
                 208121_S_AT, 211676_S_AT, 1554600_S_AT, 238669_AT, 235295_AT, 203233_AT, 204105_S_AT, 
               
               
                   
                   
                 201313_AT, 219994_AT, 201125_S_AT, 217279_X_AT, 201243_S_AT, 204912_AT, 201069_AT, 
               
               
                   
                   
                 211924_S_AT, 222877_AT, 241938_AT, 203217_S_AT, 209079_X_AT, 206488_S_AT, 206171_AT, 
               
               
                   
                   
                 220066_AT, 228640_AT, 203939_AT, 205542_AT, 243894_AT, 204359_AT, 213428_S_AT, 205891_AT, 
               
               
                   
                   
                 204736_S_AT, 203665_AT, 204450_S_AT, 202748_AT, 208816_X_AT, 239519_AT, 209835_X_AT 
               
               
                   
                   
                 208161_S_AT, 209921_AT, 204715_AT, 223502_S_AT, 212086_X_AT, 220484_AT, 203887_S_AT 
               
               
                   
                   
                 223939_AT, 209146_AT, 202968_S_AT, 209392_AT, 241773_AT, 224859_AT, 209993_AT, 201324_AT, 
               
               
                   
                   
                 201012_AT, 212464_S_AT, 216442_X_AT, 213503_X_AT, 227240_AT, 210427_X_AT, 214724_AT, 
               
               
                   
                   
                 226218_AT, 204991_AT, 200748_S_AT, 227107_AT, 204401_AT, 211661_X_AT, 222062_AT, 
               
               
                   
                   
                 202686_S_AT, 203548_S_AT, 223092_AT, 225188_AT, 217552_X_AT, 202827_S_AT, 205419_AT, 
               
               
                   
                   
                 202071_AT, 210839_AT, 235299_AT, 224701_AT, 215332_AT, 202827_S_AT, 220313_AT, 
               
               
                   
                   
                 205718_AT, 203888_AT, 212372_AT, 203935_AT, 223796_AT, 212049_AT, 212096_S_AT, 210258_AT, 
               
               
                   
                   
                 1556583_A_AT, 229797_AT, 218223_S_AT, 226302_AT, 203411_S_AT, 241929_AT, 210173_AT, 
               
               
                   
                   
                 202067_S_AT, 219434_AT, 215688_AT, 205098_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 202540_S_AT, 203465_AT, 219028_AT, 212298_AT, 204972_AT, 212014_X_AT, 221731_X_AT, 
               
               
                   
                 BP_ALL 
                 216834_AT, 203923_S_AT, 207674_AT, 211068_AT, 205067_AT, 202859_X_AT, 201170_S_AT, 217173_S_AT, 
               
               
                   
                   
                 204489_S_AT, 204620_S_AT, 211307_S_AT, 201147_S_AT, 201565_S_AT, 203922_S_AT, 2218715_AT, 1552914_A_AT, 
               
               
                   
                   
                 213562_S_AT, 1555832_S_AT, 223876_AT, 2064495_S_AT, 208435_S_AT, 234211_AT, 216748_S_AT, 63825_AT, 
               
               
                   
                   
                 205463_S_AT, 1405_I_AT, 201566_X_AT, 209949_AT, 211719_X_AT, 223501_AT, 229830_AT, 204058_AT, 
               
               
                   
                   
                 202086_AT, 205093_S_AT, 1557905_S_AT, 235944_AT, 238542_AT, 209670_AT, 209047_AT, 217074_S_AT, 
               
               
                   
                   
                 201150_S_AT, 2011          _S_AT, 155          _AT, 217757_AT, 20405          _S_AT, 2132          1_AT, 201626_AT, 212          _S_AT 
               
               
                   
                   
                 23          669_AT, 2          223_AT, 3702          _AT, 201243_S_AT, 217757_AT, 20          _AT, 2          77_AT, 20270          _S_AT, 201041_S_AT, 
               
               
                   
                   
                 222          3_AT, 202434_S_AT, 212657_S_AT, 2064          _S_AT, 220066_AT, 200878_AT, 203          _AT, 205          1_AT, 
               
               
                   
                   
                 23445          _S_AT, 20274          _AT, 23          19_AT, 20          35_X_AT, 225116_AT, 204715_AT, 22          502_S_AT, 201466_S_AT, 
               
               
                   
                   
                 2          7_S_AT, 2029          _S_AT, 20          37_S_AT, 20253          _S_AT, 23621          _AT, 21          4_S_AT, 2007          _S_AT, 204401_AT, 
               
               
                   
                   
                 202686_S_AT, 2220          2_AT, 210512_S_AT, 217552_X_AT, 211527_X_AT, 203140_AT, 220266_S_AT, 202241_AT, 
               
               
                   
                   
                 202044_X_AT, 20          925_AT, 15565          _A_AT, 229797_AT, 215          _AT, 2010          _AT, 229221_AT, 210          95_X_AT, 
               
               
                   
                   
                 22013          _AT, 209555_S_AT, 202435_S_AT, 2162          3_S_AT, 201473_AT, 203074_AT, 220916_S_AT, 201471_S_AT, 
               
               
                   
                   
                 2          573          _AT, 20          2_AT, 20282          _S_AT, 236361_AT, 2022          _S_AT, 20          27_S_AT, 201925_S_AT, 22          0_AT, 
               
               
                   
                   
                 213577_AT, 229937_X_AT, 225115_AT, 20          50          _AT, 210          45_S_AT, 203005_AT, 201242_S_AT, 20          1_S_AT, 
               
               
                   
                   
                 233220_AT, 207          9_S_AT, 242907_AT, 209122_AT, 213293_S_AT, 1          0020_AT, 237252_AT, 212171_X_AT,           02_AT 
               
               
                   
                   
                 230233_AT, 2148          _AT, 20          566_AT, 20          4_S_AT, 1552690_A_AT, 23          818_X_AT, 21767          _AT, 2214          3_AT, 
               
               
                   
                   
                 20          436_S_AT, 23          _AT, 20          06_AT, 20172          _AT, 20          21          _AT, 20276          _AT, 224606_AT, 210513_S_AT 
               
               
                   
                   
                 215646_S_AT, 204619_S_AT, 233295_AT, 201313_AT, 215451_AT, 2250          7_AT, 217279_X_AT, 201627_S_AT, 
               
               
                   
                   
                 20106          _AT, 205552_S_AT, 221341_S_AT, 211524_S_AT, 212          _AT, 213763_AT, 206171_AT, 202          14_AT, 
               
               
                   
                   
                 204490_S_AT, 202436_S_AT, 20114          _S_AT, 20          21_AT, 20          157_AT, 22          7_AT, 204          _AT, 220          4_AT, 
               
               
                   
                   
                 225368_AT, 20          2_AT, 22          _AT, 201          25_S_AT, 20          _AT, 201012_AT, 2124          4_S_AT, 216442_X_AT, 
               
               
                   
                   
                 20          22_X_AT, 241722_X_AT, 227107_AT, 221          1_X_AT, 20          27_S_AT, 22          0          2_AT, 22          1          _S_AT,           71          0_AT, 
               
               
                   
                   
                 205415_AT, 15          2467_AT, 210          _S_AT, 20          65_S_AT,           571_S_AT, 20          55_AT, 15          2553_A_AT, 20          1          _AT, 
               
               
                   
                   
                            02437_S_AT, 2020          _S_AT, 212372_AT, 20          _AT, 227          7_AT, 217222_S_AT,           56575          _A_AT, 241          29_AT, 
               
               
                   
                   
                 202067_S_AT, 215434_AT,           11571_S_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 229221_AT, 201465_S_AT, 210495_X_AT, 21229          _AT, 209555_S_AT, 216243_S_AT, 
               
               
                   
                 BP_ALL 
                 212014_X_AT, 221731_X_AT, 201473_AT, 203923_S_AT, 203074_AT, 210916_S_AT, 235739_AT, 
               
               
                   
                   
                 20          960_S_AT, 202828_S_AT, 205067_AT, 202859_X_AT, 202284_S_AT, 209827_S_AT, 201925_S_AT, 
               
               
                   
                   
                 201170_S_AT, 204489_S_AT, 228490_AT, 204620_S_AT, 201147_S_AT, 203922_S_AT, 221815_AT, 
               
               
                   
                   
                 1555832_S_AT, 228766_AT, 203508_AT, 210          45_S_AT, 201005_AT, 208961_S_AT, 233220_AT, 
               
               
                   
                   
                 237252_AT, 160020_AT, 216248_S_AT, 63825_AT, 39402_AT, 205463_S_AT, 210233_AT, 1405_I_AT, 
               
               
                   
                   
                 214          66_AT, 211719_X_AT, 229830_AT, 205099_S_AT, 205566_AT, 1557905_S_AT, 235944_AT, 
               
               
                   
                   
                 221463_AT, 208436_S_AT, 201150_S_AT, 201148_S_AT, 209906_AT, 217757_AT, 213281_AT, 
               
               
                   
                   
                 224606_AT, 204619_S_AT, 215646_S_AT, 217279_X_AT, 37152_AT, 221841_S_AT, 211924_S_AT, 
               
               
                   
                   
                 222877_AT, 201041_S_AT, 212657_S_AT, 206488_S_AT, 206171_AT, 220066_AT, 205891_AT, 
               
               
                   
                   
                 203665_AT, 204490_S_AT, 201149_S_AT, 239519_AT, 209835_X_AT, 206157_AT, 201466_S_AT, 
               
               
                   
                   
                 225337_AT, 204035_AT, 203887_S_AT, 209392_AT, 201012_AT, 212464_S_AT, 216442_X_AT, 
               
               
                   
                   
                 204622_X_AT, 211661_X_AT, 202686_S_AT, 217552_X_AT, 202827_S_AT, 87100_AT, 210839_S_AT, 
               
               
                   
                   
                 204465_S_AT, 220266_S_AT, 204655_AT, 1552553_A_AT, 209189_AT, 201044_X_AT, 203888_AT, 
               
               
                   
                   
                 212372_AT, 203935_AT, 1556583_A_AT, 227697_AT, 1555759_A_AT, 241929_AT, 211571_S_AT, 
               
               
                   
                   
                 205098_AT 
               
               
                   
                 GOTERM —   
                 229221_AT, 210495_X_AT, 37152_AT, 212298_AT, 209555_S_AT, 216243_S_AT, 211924_S_AT, 
               
               
                   
                 BP_ALL 
                 212014_X_AT, 221731_X_AT, 203923_S_AT, 203074_AT, 210016_S_AT, 212657_S_AT, 206488_S_AT, 
               
               
                   
                   
                 20          960_S_AT, 206171_AT, 205067_AT, 202859_X_AT, 201925_S_AT, 204489_S_AT, 22          490_AT, 
               
               
                   
                   
                 203665_AT, 204490_S_AT, 204620_S_AT, 201149_S_AT, 201147_S_AT, 239519_AT, 209835_X_AT, 
               
               
                   
                   
                 203922_S_AT, 206157_AT, 221815_AT, 225337_AT, 204035_AT, 203887_S_AT, 1555832_S_AT, 
               
               
                   
                   
                 228766_AT, 203508_AT, 210845_S_AT, 201005_AT, 208961_S_AT, 201012_AT, 212464_S_AT, 
               
               
                   
                   
                 237252_AT, 216442_X_AT, 39402_AT, 63825_AT, 205463_S_AT, 210233_AT, 1405_I_AT, 214866_AT, 
               
               
                   
                   
                 211719_X_AT, 229830_AT, 205099_S_AT, 211661_X_AT, 205566_AT, 1557905_S_AT, 235944_AT, 
               
               
                   
                   
                 217552_X_AT, 208436_S_AT, 221463_AT, 87100_AT, 201150_S_AT, 204465_S_AT, 201148_S_AT, 
               
               
                   
                   
                 209906_AT, 217757_AT, 224606_AT, 204655_AT, 1552553_A_AT, 209159_AT, 215646_S_AT, 
               
               
                   
                   
                 204619_S_AT, 203888_AT, 212372_AT, 203935_AT, 1555759_A_AT, 241929_AT, 211571_S_AT, 
               
               
                   
                   
                 205098_AT 
               
               
                   
                 GOTERM —   
                 223723_AT, 229221_AT, 209555_S_AT, 212014_X_AT, 203923_S_AT, 205217_S_AT, 210916_S_AT, 
               
               
                   
                 CC_ALL 
                 207674_AT, 206488_S_AT, 206171_AT, 202828_S_AT, 236561_AT, 228640_AT, 201925_S_AT, 
               
               
                   
                   
                 205542_AT, 217173_S_AT, 204489_S_AT, 204359_AT, 204736_S_AT, 205          91_AT, 204490_S_AT, 
               
               
                   
                   
                 211307_S_AT, 209          35_X_AT, 208161_S_AT, 203922_S_AT, 203104_AT, 202756_S_AT, 203887_S_AT, 
               
               
                   
                   
                 228766_AT, 241773_AT, 209392_AT, 201005_AT, 201242_S_AT, 233230_AT, 207819_S_AT, 
               
               
                   
                   
                 160020_AT, 237252_AT, 214297_AT, 210333_AT, 22          910_AT, 209949_AT, 205534_AT, 204661_AT, 
               
               
                   
                   
                 34210_AT, 205099_S_AT, 204401_AT, 211661_X_AT, 1557905_S_AT, 202          86_S_AT, 222062_AT, 
               
               
                   
                   
                 22          754_AT, 209670_AT, 202827_S_AT, 217552_X_AT, 22          092_AT, 209047_AT, 205419_AT, 
               
               
                   
                   
                 202071_AT, 210839_S_AT, 209906_AT, 202068_S_AT, 205          20_AT, 211030_S_AT, 211676_S_AT, 
               
               
                   
                   
                 208121_S_AT, 205718_AT, 203888_AT, 203935_AT, 203253_AT, 204105_S_AT, 1556583_A_AT, 
               
               
                   
                   
                 225302_AT, 210173_AT, 241929_AT, 217279_X_AT, 201125_S_AT, 202067_S_AT, 201243_S_AT, 
               
               
                   
                   
                 205098_AT 
               
               
                   
                 GOTERM —   
                 223723_AT, 229221_AT, 209555_S_AT, 212014_X_AT, 203923_S_AT, 203217_S_AT, 210916_S_AT, 
               
               
                   
                 CC_ALL 
                 207674_AT, 206488_S_AT, 206171_AT, 202828_S_AT, 236561_AT, 228640_AT, 201925_S_AT, 
               
               
                   
                   
                 205542_AT, 217173_S_AT, 204489_S_AT, 204359_AT, 204736_S_AT, 205891_AT, 204490_S_AT, 
               
               
                   
                   
                 211307_S_AT, 209835_X_AT, 208161_S_AT, 203922_S_AT, 203104_AT, 202756_S_AT, 203887_S_AT, 
               
               
                   
                   
                 228766_AT, 241773_AT, 209392_AT, 201005_AT, 201242_S_AT, 233220_AT, 207819_S_AT, 
               
               
                   
                   
                 160020_AT, 237252_AT, 214297_AT, 210233_AT, 228910_AT, 209949_AT, 205534_AT, 204661_AT, 
               
               
                   
                   
                 34210_AT, 205099_S_AT, 204401_AT, 211661_X_AT, 1557905_S_AT, 202686_S_AT, 222062_AT, 
               
               
                   
                   
                 228754_AT, 209670_AT, 202827_S_AT, 217552_X_AT, 223092_AT, 209047_AT, 205419_AT, 
               
               
                   
                   
                 202071_AT, 210839_S_AT, 209906_AT, 202068_S_AT, 205920_AT, 211030_S_AT, 211676_S_AT, 
               
               
                   
                   
                 208121_S_AT, 205718_AT, 203888_AT, 203935_AT, 203233_AT, 204105_S_AT, 1556583_A_AT, 
               
               
                   
                   
                 226302_AT, 210173_AT, 241929_AT, 217279_X_AT, 201125_S_AT, 202067_S_AT, 201243_S_AT, 
               
               
                   
                   
                 205098_AT 
               
               
                   
                 GOTERM —   
                 229221_AT, 223723_AT, 210495_X_AT, 212298_AT, 216243_S_AT, 212014_X_AT, 221731_X_AT, 
               
               
                   
                 CC_ALL 
                 210916_S_AT, 207674_AT, 202828_S_AT, 205067_AT, 228648_AT, 202859_X_AT, 226545_AT, 
               
               
                   
                   
                 209827_S_AT, 217173_S_AT, 204489_S_AT, 204620_S_AT, 211307_S_AT, 201147_S_AT, 201590_X_AT, 
               
               
                   
                   
                 202756_S_AT, 205495_S_AT, 204834_AT, 203508_AT, 228873_AT, 210845_S_AT, 210095_S_AT, 
               
               
                   
                   
                 209122_AT, 237252_AT, 160020_AT, 212171_X_AT, 39402_AT, 205463_S_AT, 210233_AT, 1405_I_AT, 
               
               
                   
                   
                 211719_X_AT, 214866_AT, 223501_AT, 229830_AT, 1557905_S_AT, 206835_AT, 238542_AT, 
               
               
                   
                   
                 235944_AT, 221463_AT, 201150_S_AT, 201148_S_AT, 217757_AT, 229004_AT, 204619_S_AT, 
               
               
                   
                   
                 215646_S_AT, 210513_S_AT, 203233_AT, 202087_S_AT, 216546_S_AT, 217279_X_AT, 201069_AT, 
               
               
                   
                   
                 211924_S_AT, 204222_S_AT, 212657_S_AT, 203665_AT, 213428_S_AT, 204359_AT, 204490_S_AT, 
               
               
                   
                   
                 208816_X_AT, 201149_S_AT, 239519_AT, 209835_X_AT, 212190_AT, 206157_AT, 223502_S_AT, 
               
               
                   
                   
                 212143_S_AT, 202458_AT, 204035_AT, 225955_AT, 203887_S_AT, 228762_AT, 209392_AT, 
               
               
                   
                   
                 212464_S_AT, 216442_X_AT, 213503_X_AT, 210427_X_AT, 226218_AT, 203940_S_AT, 227265_AT, 
               
               
                   
                   
                 219908_AT, 203548_S_AT, 210512_S_AT, 202827_S_AT, 225186_S_AT, 211527_X_AT, 204475_AT, 
               
               
                   
                   
                 210839_S_AT, 204655_AT, 202068_S_AT, 203888_AT, 1555759_A_AT, 219434_AT, 202067_S_AT, 
               
               
                   
                   
                 211571_S_AT 
               
               
                   
                 GOTERM —   
                 229223_AT, 210495_X_AT, 201069_AT, 216243_S_AT, 212014_X_AT, 221731_X_AT, 210916_S_AT, 
               
               
                   
                 CC_ALL 
                 212657_S_AT, 202828_S_AT, 205067_AT, 202859_X_AT, 226545_AT, 209827_S_AT, 217173_S_AT, 
               
               
                   
                   
                 204489_S_AT, 203665_AT, 204359_AT, 213428_S_AT, 204490_S_AT, 208816_X_AT, 204620_S_AT, 
               
               
                   
                   
                 201149_S_AT, 201147_S_AT, 209835_X_AT, 201590_X_AT, 212190_AT, 223502_S_AT, 212143_S_AT, 
               
               
                   
                   
                 204035_AT, 202756_S_AT, 203887_S_AT, 205495_S_AT, 204834_AT, 228873_AT, 210095_S_AT, 
               
               
                   
                   
                 212464_S_AT, 160020_AT, 237252_AT, 216442_X_AT, 212171_X_AT, 213503_X_AT, 39402_AT, 
               
               
                   
                   
                 205463_S_AT, 1405_I_AT, 210427_X_AT, 211719_X_AT, 223501_AT, 229830_AT, 1557905_S_AT, 
               
               
                   
                   
                 203940_S_AT, 227265_AT, 238542_AT, 203548_S_AT, 235944_AT, 219908_AT, 210512_S_AT, 
               
               
                   
                   
                 202827_S_AT, 221463_AT, 211527_X_AT, 204475_AT, 202150_S_AT, 201148_S_AT, 217757_AT, 
               
               
                   
                   
                 229004_AT, 204655_AT, 210513_S_AT, 215646_S_AT, 204619_S_AT, 202068_S_AT, 203888_AT, 
               
               
                   
                   
                 1555759_A_AT, 216546_S_AT, 217279_X_AT, 202067_S_AT, 211571_S_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 201465_S_AT, 210495_X_AT, 37152_AT, 212298_AT, 210136_AT, 209555_S_AT, 
               
               
                   
                 BP_ALL 
                 227948_AT, 221841_S_AT, 201473_AT, 204923_AT, 206488_S_AT, 1566901_AT, 214255_AT, 
               
               
                   
                   
                 205067_AT, 236561_AT, 1569149_AT, 216017_S_AT, 203665_AT, 205891_AT, 204998_S_AT, 
               
               
                   
                   
                 212099_AT, 201565_S_AT, 239519_AT, 201466_S_AT, 1552914_A_AT, 212143_S_AT, 215602_AT, 
               
               
                   
                   
                 228766_AT, 208937_S_AT, 205312_AT, 224859_AT, 210095_S_AT, 212464_S_AT, 216442_X_AT, 
               
               
                   
                   
                 212171_X_AT, 39402_AT, 1405_I_AT, 201566_X_AT, 211719_X_AT, 226218_AT, 202191_S_AT, 
               
               
                   
                   
                 218559_S_AT, 206835_AT, 222062_AT, 203940_S_AT, 200921_S_AT, 203548_S_AT, 210512_S_AT, 
               
               
                   
                   
                 223092_AT, 222670_S_AT, 200920_S_AT, 211527_X_AT, 203751_X_AT, 203140_AT, 220266_S_AT, 
               
               
                   
                   
                 220935_S_AT, 213281_AT, 204655_AT, 210513_S_AT, 1564754_X_AT, 212372_AT, 203935_AT, 
               
               
                   
                   
                 1565752_AT, 203233_AT, 204105_S_AT, 227697_AT, 203752_S_AT, 219257_S_AT, 212803_AT, 
               
               
                   
                   
                 1555759_A_AT, 241929_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 201465_S_AT, 210136_AT, 212298_AT, 204923_AT, 235739_AT, 240665_AT, 
               
               
                   
                 BP_ALL 
                 206171_AT, 1566901_AT, 205067_AT, 236561_AT, 220066_AT, 200878_AT, 201170_S_AT, 
               
               
                   
                   
                 1569149_AT, 216017_S_AT, 205891_AT, 203665_AT, 204998_S_AT, 208816_X_AT, 212099_AT, 
               
               
                   
                   
                 201565_S_AT, 239519_AT, 201590_X_AT, 204715_AT, 201466_S_AT, 1552914_A_AT, 212143_S_AT, 
               
               
                   
                   
                 205312_AT, 208937_S_AT, 224859_AT, 210095_S_AT, 216248_S_AT, 213503_X_AT, 212171_X_AT, 
               
               
                   
                   
                 39402_AT, 204622_X_AT, 205463_S_AT, 1405_I_AT, 201566_X_AT, 210427_X_AT, 226218_AT, 
               
               
                   
                   
                 218934_S_AT, 229830_AT, 218559_S_AT, 227107_AT, 206835_AT, 222062_AT, 203940_S_AT, 
               
               
                   
                   
                 200921_S_AT, 222670_S_AT, 210512_S_AT, 223092_AT, 200920_S_AT, 202071_AT, 211527_X_AT, 
               
               
                   
                   
                 1562467_AT, 203751_X_AT, 1554992_AT, 203140_AT, 213281_AT, 220935_S_AT, 204655_AT, 
               
               
                   
                   
                 210513_S_AT, 238669_AT, 235295_AT, 203935_AT, 203233_AT, 204105_S_AT, 1556583_A_AT, 
               
               
                   
                   
                 203752_S_AT, 219257_S_AT, 212803_AT, 1555759_A_AT, 215688_AT 
               
               
                   
                 GOTERM —   
                 204912_AT, 229221_AT, 37152_AT, 212298_AT, 209555_S_AT, 216243_S_AT, 211924_S_AT, 
               
               
                   
                 MF_ALL 
                 212014_X_AT, 222877_AT, 210916_S_AT, 211352_S_AT, 235739_AT, 212657_S_AT, 207674_AT, 
               
               
                   
                   
                 206488_S_AT, 206171_AT, 242871_AT, 236561_AT, 217173_S_AT, 204489_S_AT, 205891_AT, 
               
               
                   
                   
                 204490_S_AT, 207610_S_AT, 220307_AT, 211307_S_AT, 239519_AT, 209835_X_AT, 218856_AT, 
               
               
                   
                   
                 21          686_S_AT, 229937_X_AT, 207700_S_AT, 203104_AT, 212977_AT, 223939_AT, 203887_S_AT, 
               
               
                   
                   
                 228766_AT, 203508_AT, 210845_S_AT, 241773_AT, 209392_AT, 233220_AT, 204774_AT, 
               
               
                   
                   
                 214581_X_AT, 237252_AT, 216248_S_AT, 204622_X_AT, 210233_AT, 214866_AT, 226218_AT, 
               
               
                   
                   
                 205099_S_AT, 211661_X_AT, 1557905_S_AT, 2026          6_S_AT, 222062_AT, 209670_AT, 235944_AT, 
               
               
                   
                   
                 238542_AT, 217552_X_AT, 217078_S_AT, 205419_AT, 202071_AT, 210839_S_AT, 209906_AT, 
               
               
                   
                   
                 221840_AT, 202068_S_AT, 211676_S_AT, 208121_S_AT, 220313_AT, 205718_AT, 203888_AT, 
               
               
                   
                   
                 203935_AT, 203233_AT, 210173_AT, 241929_AT, 201125_S_AT, 202067_S_AT, 219434_AT, 2050          8_AT 
               
               
                   
                 GOTERM —   
                 229221_AT, 21229          _AT, 209555_S_AT, 216243_S_AT, 212014_X_AT, 216834_AT, 210916_S_AT, 
               
               
                   
                 MF_ALL 
                 211352_S_AT, 235739_AT, 207674_AT, 242871_AT, 236561_AT, 217173_S_AT, 2044          _S_AT, 
               
               
                   
                   
                 203760_S_AT, 207610_S_AT, 220307_AT, 211307_S_AT, 229937_X_AT, 218686_S_AT, 207700_S_AT, 
               
               
                   
                   
                 20          104_AT, 212977_AT, 228766_AT, 203508_AT, 210845_S_AT, 233220_AT, 237252_AT, 
               
               
                   
                   
                 214581_X_AT, 214297_AT, 216248_S_AT, 220233_AT, 1405_I_AT, 214866_AT, 205099_S_AT, 
               
               
                   
                   
                 1557905_S_AT, 235          44_AT, 238542_AT, 209670_AT, 217078_S_AT, 209906_AT, 221          40_AT, 
               
               
                   
                   
                 20          121_S_AT, 211676_S_AT, 203233_AT, 217591_AT, 201125_S_AT, 204912_AT, 37152_AT, 
               
               
                   
                   
                 211924_S_AT, 222877_AT, 212657_S_AT, 2064          _S_AT, 206171_AT, 200878_AT, 202388_AT, 
               
               
                   
                   
                 204736_S_AT, 205891_AT, 203665_AT, 204359_AT, 204490_S_AT, 239519_AT, 20          35_X_AT, 
               
               
                   
                   
                 218856_AT, 203887_S_AT, 223939_AT, 202988_S_AT, 209392_AT, 241773_AT, 204774_AT, 
               
               
                   
                   
                 204622_X_AT, 214724_AT, 226218_AT, 211661_X_AT, 222062_AT, 2026          6_S_AT, 225207_AT, 
               
               
                   
                   
                 217552_AT, 205419_AT, 202071_AT, 210839_S_AT, 204655_AT, 202068_S_AT, 214054_AT, 
               
               
                   
                   
                 220313_AT, 205718_AT, 201          88_AT, 203935_AT, 203761_AT, 210258_AT, 1555759_A_AT, 210173_AT, 
               
               
                   
                   
                 241929_AT, 21          34_AT, 202067_S_AT, 203320_AT, 2050          _AT 
               
               
                   
                 GOTERM —   
                 229221_AT, 212298_AT, 209555_S_AT, 216243_S_AT, 212014_X_AT, 216834_AT, 210916_S_AT, 
               
               
                   
                 MF_ALL 
                 211352_S_AT, 23573          _AT, 207574_AT, 242871_AT, 232563_AT, 217173_S_AT, 2044          9_S_AT, 
               
               
                   
                   
                 203760_S_AT, 207610_S_AT, 220307_AT, 211307_S_AT, 229937_X_AT, 21          6_S_AT, 207700_S_AT, 
               
               
                   
                   
                 203104_AT, 212977_AT, 228766_AT, 20          50          _AT, 210845_S_AT, 233220_AT, 237252_AT, 
               
               
                   
                   
                 214581_X_AT, 214297_AT, 216248_S_AT, 210233_AT, 1405_I_AT, 214          6_AT, 205099_S_AT 
               
               
                   
                   
                 1557905_S_AT, 235944_AT, 23          542_AT, 209670_AT, 217078_AT, 209906_AT, 221          40_AT, 
               
               
                   
                   
                 2          121_S_AT, 211676_S_AT, 203233_AT, 2175          1_AT, 201125_S_AT, 204912_AT, 37152_AT, 
               
               
                   
                   
                 211924_S_AT, 222877_AT, 212657_S_AT, 2064          _S_AT, 206171_AT, 200          7          _AT, 202388_AT, 
               
               
                   
                   
                 204736_S_AT, 20          1_AT, 203665_AT, 204359_AT, 204490_S_AT, 239519_AT, 209835_X_AT, 
               
               
                   
                   
                 218856_AT, 203          7_S_AT, 223939_AT, 20298          _S_AT, 209392_AT, 241773_AT, 204774_AT, 
               
               
                   
                   
                 204622_X_AT, 214724_AT, 226214_AT, 211661_X_AT, 222062_AT, 202686_S_AT, 225207_AT, 
               
               
                   
                   
                 217552_X_AT, 205419_AT, 202071_AT, 210          39_S_AT, 204655_AT, 202068_S_AT, 214054_AT, 
               
               
                   
                   
                 220313_AT, 20571          _AT, 203888_AT, 203935_AT, 20          761_AT, 210258_AT, 155575          _A_AT, 210173_AT, 
               
               
                   
                   
                 241          29_AT, 219434_AT, 202067_S_AT, 203320_AT, 20509          _AT 
               
               
                   
                 GOTERM —   
                 237252_AT, 204912_AT, 21229          _AT, 20          555_S_AT, 210233_AT, 222877_AT, 22621          _AT, 
               
               
                   
                 MF_ALL 
                 205099_S_AT, 211661_X_AT, 206488_S_AT, 222062_AT, 202686_S_AT, 206171_AT, 238542_AT, 
               
               
                   
                   
                 235944_AT, 236561_AT, 217552_X_AT, 205419_AT, 210          39_S_AT, 217173_S_AT, 20          906_AT, 
               
               
                   
                   
                 205          1_AT, 207610_S_AT, 221840_AT, 239519_AT, 202068_S_AT, 20          121_S_AT, 211676_S_AT, 
               
               
                   
                   
                 220313_AT, 203888_AT, 203935_AT, 203104_AT, 203233_AT, 212977_AT, 203887_S_AT, 223939_AT, 
               
               
                   
                   
                 228766_AT, 203508_AT, 20          92_AT, 24192          _AT, 241773_AT, 210173_AT, 202067_S_AT, 233220_AT, 
               
               
                   
                   
                 204774_AT, 2050          8_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 160020_AT, 201465_S_AT, 229221_AT, 201069_AT, 212171_X_AT, 213503_X_AT, 
               
               
                   
                 BP_ALL 
                 21229          _AT, 214297_AT, 39402_AT, 205463_S_AT, 212014_X_AT, 210427_X_AT, 201473_AT, 
               
               
                   
                   
                 222          77_AT, 210916_S_AT, 24193          _AT, 22          30_AT, 1557905_S_AT, 211962_S_AT, 202          2          _S_AT, 
               
               
                   
                   
                 205067_AT, 210512_S_AT, 202827_S_AT, 202          59_X_AT, 236561_AT, 211527_X_AT, 200          78_AT, 
               
               
                   
                   
                 204489_S_AT, 20          5_AT, 204736_S_AT, 204490_S_AT, 2132          1_AT, 212099_AT, 208816_X_AT, 
               
               
                   
                   
                 310513_S_AT, 239519_AT, 209          35_X_AT, 201590_X_AT, 201466_S_AT, 203955_AT, 204035_AT, 
               
               
                   
                   
                 212124_AT, 20          37_S_AT, 210173_AT, 2172          _X_AT 
               
               
                   
                 GOTERM —   
                 229221_AT, 223723_AT, 210495_X_AT, 210136_AT, 209555_S_AT, 212014_X_AT, 203923_S_AT, 
               
               
                   
                 CC_ALL 
                 210915_S_AT, 219412_AT, 207674_AT, 202828_S_AT, 236561_AT, 201925_S_AT, 217173_S_AT, 
               
               
                   
                   
                 204489_S_AT, 220          07_AT, 211307_S_AT, 223303_AT, 203922_S_AT, 214          30_AT, 1552914_A_AT, 
               
               
                   
                   
                 203304_AT, 202756_S_AT, 228766_AT, 230          25_AT, 201005_AT, 206033_S_AT, 201242_S_AT, 
               
               
                   
                   
                 233220_AT, 242907_AT, 207819_S_AT, 237252_AT, 160020_AT, 214297_AT, 210233_AT, 228910_AT, 
               
               
                   
                   
                 209949_AT, 211719_X_AT, 34210_AT, 205534_AT, 2050          _S_AT, 20          94_S_AT, 1557905_S_AT, 
               
               
                   
                   
                 22          754_AT, 23          542_AT, 209670_AT, 209047_AT, 238581_AT, 209906_AT, 211030_S_AT, 205520_AT, 
               
               
                   
                   
                 20          121_S_AT, 211676_S_AT, 2352          5_AT, 204105_S_AT, 20          233_AT, 219994_AT, 201125_S_AT, 
               
               
                   
                   
                 217279_X_AT, 201243_S_AT, 203217_S_AT, 2064          _S_AT, 206171_AT, 22          640_AT, 205542_AT, 
               
               
                   
                   
                 204736_S_AT, 205891_AT, 203665_AT, 20435          _AT, 204490_S_AT, 202748_AT, 209835_X_AT, 
               
               
                   
                   
                 20          161_S_AT, 204715_AT, 203887_S_AT, 209392_AT, 241773_AT, 224859_AT, 209999_AT, 
               
               
                   
                   
                 201012_AT, 212464_S_AT, 216442_X_AT, 214724_AT, 226218_AT, 204661_AT, 227107_AT, 
               
               
                   
                   
                 204401_AT, 211661_X_AT, 222062_AT, 202686_S_AT, 217552_X_AT, 225188_AT, 2230          2_AT, 
               
               
                   
                   
                 202          27_S_AT, 205419_AT, 202071_AT, 210839_S_AT, 219332_AT, 20206          _S_AT, 20671          _AT, 
               
               
                   
                   
                 203888_AT, 203935_AT, 15565          3_A_AT, 22          302_AT, 241929_AT, 210173_AT, 202067_S_AT, 
               
               
                   
                   
                 205098_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 202540_S_AT, 227069_AT, 229221_AT, 201465_S_AT, 210136_AT, 21229          _AT, 
               
               
                   
                 BP_ALL 
                 212014_X_AT, 221731_X_AT, 201473_AT, 210          16_S_AT, 235739_AT, 206472_S_AT, 20          960_S_AT, 
               
               
                   
                   
                 202828_S_AT, 205067_AT, 209          03_S_AT, 23          561_AT, 230360_AT, 202          59_X_AT, 2022          4_S_AT, 
               
               
                   
                   
                 1569149_AT, 2044          9_S_AT, 216017_S_AT, 204620_S_AT, 2120          9_AT, 201147_S_AT, 201565_S_AT, 
               
               
                   
                   
                 201590_X_AT, 232649_AT, 204653_AT, 1555832_S_AT, 210          45_S_AT, 243556_AT, 201005_AT, 
               
               
                   
                   
                 20          61_S_AT, 233220_AT, 210095_S_AT, 160020_AT, 234967_AT, 216248_S_AT, 214297_AT, 
               
               
                   
                   
                 212171_X_AT, 39402_AT, 205463_S_AT, 201566_X_AT, 214866_AT, 22          964_AT, 202191_S_AT, 
               
               
                   
                   
                 229          30_AT, 1557905_S_AT, 21          502_S_AT, 20          35_AT, 222670_S_AT, 201150_S_AT, 203751_X_AT, 
               
               
                   
                   
                 20114          _S_AT, 1554992_AT, 213283_AT, 224606_AT, 204619_S_AT, 215646_S_AT, 210513_S_AT, 
               
               
                   
                   
                 1554600_S_AT, 204105_S_AT, 204          1_S_AT, 203752_S_AT, 212          03_AT, 225557_AT, 217279_X_AT, 
               
               
                   
                   
                 37152_AT, 20106          _AT, 221          41_S_AT, 211924_S_AT, 22421          _S_AT, 222          77_AT, 241938_AT, 
               
               
                   
                   
                 211962_S_AT, 15          6901_AT, 200          78_AT, 204141_AT, 204736_S_AT, 203665_AT, 2044          0_S_AT, 
               
               
                   
                   
                 204998_S_AT, 20          816_X_AT, 201149_S_AT, 23          519_AT, 209835_X_AT, 212190_AT, 201466_S_AT, 
               
               
                   
                   
                 212143_S_AT, 204035_AT, 212086_X_AT, 220484_AT, 212124_AT, 20          37_S_AT, 22          762_AT, 
               
               
                   
                   
                 222651_S_AT, 2119          6_AT, 230529_AT, 201324_AT, 201012_AT, 202539_S_AT, 213503_X_AT, 
               
               
                   
                   
                 204622_X_AT, 227240_AT, 210427_X_AT, 226218_AT, 21          559_S_AT, 202686_S_AT, 204          4_AT, 
               
               
                   
                   
                 219845_AT, 210512_S_AT, 223092_AT, 202          27_S_AT, 205419_AT, 211527_X_AT, 1562467_AT, 
               
               
                   
                   
                 2          4465_S_AT, 203140_AT, 220266_S_AT, 220935_S_AT, 2091          9_AT, 212372_AT, 203935_AT, 
               
               
                   
                   
                 2120          9_AT, 2019          5_AT, 227697_AT, 229797_AT, 203411_S_AT, 210173_AT, 211571_S_AT, 
               
               
                   
                   
                 2156          _AT, 203320_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 160020_AT, 2014          5_S_AT, 214297_AT, 21229          _AT, 213503_X_AT, 212171_X_AT, 
               
               
                   
                 BP_ALL 
                 39402_AT, 205463_S_AT, 210427_X_AT, 201473_AT, 222877_AT, 24193          _AT, 229          30_AT, 
               
               
                   
                   
                 211962_S_AT, 202828_S_AT, 205067_AT, 210512_S_AT, 202          5          _X_AT, 202          27_S_AT, 236561_AT, 
               
               
                   
                   
                 211527_X_AT, 200          78_AT, 20366          _AT, 204736_S_AT, 2132          1_AT, 2120          9_AT, 20          816_X_AT, 
               
               
                   
                   
                 23          519_AT, 210513_S_AT, 201590_X_AT, 201466_S_AT, 203935_AT, 204035_AT, 212124_AT, 
               
               
                   
                   
                 20          37_S_AT, 210173_AT, 21727          _X_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 160020_AT, 201465_S_AT, 229221_AT, 201069_AT, 212171_X_AT, 213503_X_AT, 
               
               
                   
                 BP_ALL 
                 212298_AT, 214297_AT, 39402_AT, 205463_S_AT, 212014_X_AT, 210427_X_AT, 201473_AT 
               
               
                   
                   
                 222          77_AT, 210916_S_AT, 241938_AT, 229          30_AT, 1557905_S_AT, 211962_S_AT, 202828_S_AT, 
               
               
                   
                   
                 205067_AT, 210512_S_AT, 202827_S_AT, 20285          _X_AT, 236561_AT, 211527_X_AT, 200          7          _AT, 
               
               
                   
                   
                 204489_S_AT, 203665_AT, 204736_S_AT, 204490_S_AT, 213281_AT, 212099_AT, 208816_X_AT 
               
               
                   
                   
                 210513_S_AT, 239519_AT, 209635_X_AT, 201590_X_AT, 201466_S_AT, 203935_AT, 204035_AT, 
               
               
                   
                   
                 212124_AT, 208937_S_AT, 210173_AT, 217279_X_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 210495_X_AT, 229221_AT, 201465_S_AT, 219028_AT, 21229          _AT, 209555_S_AT, 
               
               
                   
                 BP_ALL 
                 216243_S_AT, 212014_X_AT, 221731_X_AT, 203923_S_AT, 203074_AT, 210916_S_AT, 201471_S_AT 
               
               
                   
                   
                 235739_AT, 20          960_S_AT, 202          28_S_AT, 205067_AT, 236561_AT, 202859_X_AT, 202284_S_AT, 
               
               
                   
                   
                 201925_S_AT, 228490_AT, 204489_S_AT, 204620_S_AT, 201147_S_AT, 203922_S_AT, 221          15_AT, 
               
               
                   
                   
                 225115_AT, 1555832_S_AT, 228766_AT, 205495_S_AT, 203508_AT, 210          45_S_AT, 201005_AT, 
               
               
                   
                   
                 208961_S_AT, 201242_S_AT, 20          43          _S_AT, 237252_AT, 160020_AT, 212171_X_AT, 21624          _S_AT, 
               
               
                   
                   
                 63825_AT, 39402_AT, 205463_S_AT, 210233_AT, 1405_I_AT, 214866_AT, 211719_X_AT, 209949_AT, 
               
               
                   
                   
                 229          30_AT, 202086_AT, 20509          _S_AT, 205566_AT, 1557          05_S_AT, 23          18_X_AT, 209670_AT, 
               
               
                   
                   
                 235944_AT, 221463_AT, 20          436_S_AT, 201150_S_AT, 20114          _S_AT, 20          06_AT, 201739_AT, 
               
               
                   
                   
                 217757_AT, 213281_AT, 224606_AT, 204619_S_AT, 215646_S_AT, 20162          _AT, 210513_S_AT, 
               
               
                   
                   
                 23866          _AT, 239452_AT, 37028_AT, 2250          7_AT, 217279_X_AT, 201627_S_AT, 201243_S_AT, 
               
               
                   
                   
                 37152_AT, 201069_AT, 22794          _AT, 211924_S_AT, 202708_S_AT, 212948_AT, 201041_S_AT, 
               
               
                   
                   
                 212657_S_AT, 2064          _S_AT, 213763_AT, 206171_AT, 220066_AT, 200878_AT, 202014_AT, 
               
               
                   
                   
                 205891_AT, 203665_AT, 204490_S_AT, 201149_S_AT, 239519_AT, 209835_X_AT, 225116_AT, 
               
               
                   
                   
                 206157_AT, 201466_S_AT, 225337_AT, 204035_AT, 203887_S_AT, 225368_AT, 201625_S_AT, 
               
               
                   
                   
                 201012_AT, 212464_S_AT, 216442_X_AT, 204622_X_AT, 21          34_S_AT, 204401_AT, 211661_X_AT, 
               
               
                   
                   
                 222062_AT, 217552_X_AT, 210512_S_AT, 202827_S_AT,           7100_AT, 211527_X_AT, 15624          7_AT, 
               
               
                   
                   
                 204465_S_AT, 206573_S_AT, 203140_AT, 202241_AT, 204655_AT, 1552553_A_AT, 2091          9_AT, 
               
               
                   
                   
                 201044_X_AT, 203          _AT, 212372_AT, 203935_AT, 1556583_A_AT, 227          7_AT, 1555759_A_AT, 
               
               
                   
                   
                 141929_AT, 211571_AT, 20509          _AT 
               
               
                   
                 GOTERM —   
                 210136_AT, 205552_S_AT, 216243_S_AT, 204972_AT, 216          34_AT, 203923_S_AT, 201471_S_AT, 
               
               
                   
                 BP_ALL 
                 207674_AT, 212657_S_AT, 205067_AT, 202859_X_AT, 220066_AT, 209827_S_AT, 201925_S_AT, 
               
               
                   
                   
                 20274          _AT, 211307_S_AT, 203922_S_AT, 229937_X_AT, 223502_S_AT, 206157_AT, 1552914_A_AT, 
               
               
                   
                   
                 20          50          _AT, 2029          _S_AT, 209392_AT, 224859_AT, 242907_AT, 213293_S_AT, 214211_AT, 
               
               
                   
                   
                 212171_X_AT, 39402_AT, 210233_AT, 1405_I_AT, 209949_AT, 22621          _AT, 223501_AT, 2050          9_S_AT, 
               
               
                   
                   
                 200748_S_AT, 211661_X_AT, 222062_AT, 238542_AT, 217552_X_AT, 210512_S_AT, 217078_S_AT, 
               
               
                   
                   
                 221463_AT, 205419_AT, 211527_X_AT, 238581_AT, 210          39_S_AT, 204655_AT, 210513_S_AT, 
               
               
                   
                   
                 203233_AT, 1555759_A_AT, 219434_AT, 205098_AT 
               
               
                   
                 GOTERM —   
                 210495_X_AT, 229221_AT, 216243_S_AT, 212014_X_AT, 203923_S_AT, 202708_S_AT, 210916_S_AT, 
               
               
                   
                 BP_ALL 
                 212          57_S_AT, 206171_AT, 205067_AT, 202859_X_AT, 220066_AT, 201925_S_AT, 204489_S_AT, 
               
               
                   
                   
                 205891_AT, 203          65_AT, 204490_S_AT, 209835_X_AT, 20          922_S_AT, 206157_AT, 204035_AT, 
               
               
                   
                   
                 205495_S_AT, 20350          _AT, 201012_AT, 20          438_S_AT, 212464_S_AT, 216442_X_AT, 39402_AT, 
               
               
                   
                   
                 210233_AT, 1405_I_AT, 21171          _X_AT, 200949_AT, 2020          _AT, 205099_S_AT, 211          61_X_AT, 
               
               
                   
                   
                 204401_AT, 1557905_S_AT, 22          062_AT, 20          670_AT, 217552_X_AT, 221463_AT, 208436_S_AT, 
               
               
                   
                   
                 209506_AT, 217757_AT, 204          55_AT, 209189_AT, 1552553_A_AT, 203935_AT, 1555759_A_AT, 
               
               
                   
                   
                 2050          _AT 
               
               
                   
                 GOTERM —   
                 202540_S_AT, 201464_X_AT, 201465_S_AT, 229221_AT, 227069_AT, 219028_AT, 210136_AT, 
               
               
                   
                 BP_ALL 
                 212298_AT, 209555_S_AT, 202435_S_AT, 212014_X_AT, 221731_X_AT, 221011_S_AT, 201473_AT, 
               
               
                   
                   
                 203074_AT, 210916_S_AT, 235739_AT, 206472_S_AT, 20          960_S_AT, 203882_AT, 202828_S_AT, 
               
               
                   
                   
                 205067_AT, 242871_AT, 209803_S_AT, 202284_S_AT, 202859_X_AT, 230360_AT, 236561_AT, 
               
               
                   
                   
                 1569149_AT, 217173_S_AT, 204489_S_AT, 216017_S_AT, 204620_S_AT, 212099_AT, 
               
               
                   
                   
                 201565_S_AT, 201147_S_AT, 201590_X_AT, 232649_AT, 204653_AT, 203104_AT, 225115_AT, 
               
               
                   
                   
                 1555832_S_AT, 22          766_AT, 210845_S_AT, 243556_AT, 201005_AT, 208961_S_AT, 233220_AT, 
               
               
                   
                   
                 210095_S_AT, 237252_AT, 160020_AT, 214297_AT, 212171_X_AT, 216248_S_AT, 224967_AT, 
               
               
                   
                   
                 39402_AT, 205463_S_AT, 201566_X_ATT, 22          64_AT, 214866_AT, 202191_S_AT, 229830_AT, 
               
               
                   
                   
                 1552690_A_AT, 1557905_S_AT, 206          35_AT, 21          502_S_AT, 235944_AT, 222670_S_AT, 209047_AT, 
               
               
                   
                   
                 203751_X_AT, 201150_S_AT, 201148_S_AT, 1554992_AT, 209906_AT, 202768_AT, 213281_AT, 
               
               
                   
                   
                 224606_AT, 204619_AT, 215646_S_AT, 210513_S_AT, 1554600_S_AT, 238669_AT, 
               
               
                   
                   
                 204105_S_AT, 204881_S_AT, 225097_AT, 203752_S_AT, 212803_AT, 225557_AT, 217591_AT, 
               
               
                   
                   
                 217279_X_AT, 37152_AT, 201069_AT, 221842_S_AT, 221924_S_AT, 224218_S_AT, 222877_AT, 
               
               
                   
                   
                 241938_AT, 212948_AT, 228083_AT, 202434_S_AT, 206488_S_AT, 213763_AT, 211962_S_AT, 
               
               
                   
                   
                 1566901_AT, 220066_AT, 200878_AT, 204141_AT, 202388_AT, 205891_AT, 204736_S_AT, 
               
               
                   
                   
                 203665_AT, 202436_S_AT, 204490_S_AT, 2049          _S_AT, 208816_X_AT, 201149_S_AT, 239519_AT, 
               
               
                   
                   
                 209835_X_AT, 225116_AT, 212190_AT, 201466_S_AT, 212143_S_AT, 204033_AT, 212086_X_AT, 
               
               
                   
                   
                 220484_AT, 203887_S_AT, 212124_AT, 225368_AT, 208937_S_AT, 228762_AT, 222651_S_AT, 
               
               
                   
                   
                 230529_AT, 211986_AT, 201324_AT, 202539_S_AT, 201012_AT, 213503_X_AT, 204622_X_AT, 
               
               
                   
                   
                 227240_AT, 241722_X_AT, 210427_X_AT, 214724_AT, 226218_AT, 228559_S_AT, 204401_AT, 
               
               
                   
                   
                 211661_X_AT, 2026          6_S_AT, 2046          4_AT, 219          45_AT, 21990          _AT, 223092_AT, 210512_S_AT, 
               
               
                   
                   
                 202827_S_AT, 205419_AT, 211527_X_AT, 204475_AT, 1562467_AT, 204465_S_AT, 203140_AT, 
               
               
                   
                   
                 220266_S_AT, 220935_S_AT, 1552553_A_AT, 202437_S_AT, 209189_AT, 202068_S_AT, 
               
               
                   
                   
                 203          88_AT, 212372_AT, 203935_AT, 2120          9_AT, 227697_AT, 201995_AT, 15565          3_A_AT, 
               
               
                   
                   
                 229797_AT, 203411_S_AT, 210173_AT, 241929_AT, 202067_S_AT, 211571_S_AT, 215688_AT, 
               
               
                   
                   
                 203320_AT 
               
               
                   
                 GOTERM —   
                 229221_AT, 216442_X_AT, 210435_X_AT, 39402_AT, 210233_AT, 216243_S_AT, 1405_I_AT, 
               
               
                   
                 BP_ALL 
                 212014_X_AT, 211719_X_AT, 230          23_S_AT, 210916_S_AT, 205099_S_AT, 211661_X_AT, 212657_S_AT, 
               
               
                   
                   
                 1557905_S_AT, 206171_AT, 205067_AT, 217552_X_AT, 202859_X_AT, 20          436_S_AT, 221463_AT, 
               
               
                   
                   
                 201925_S_AT, 20          06_AT, 2044          _S_AT, 203665_AT, 204490_S_AT, 217757_AT, 204655_AT, 
               
               
                   
                   
                 1552553_A_AT, 2091          9_AT, 209          35_X_AT, 203922_S_AT, 205157_AT, 204035_AT, 203935_AT, 
               
               
                   
                   
                 203508_AT, 1555759_A_AT, 201012_AT, 2050          _AT, 2124          4_S_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 202540_S_AT, 22706          _AT, 229221_AT, 201465_S_AT, 21902          _AT, 210136_AT, 
               
               
                   
                 BP_ALL 
                 21225          _AT, 212014_X_AT, 221731_X_AT, 201473_AT, 221011_S_AT, 210916_S_AT, 235739_AT, 
               
               
                   
                   
                 206472_S_AT, 20          960_S_AT, 202          28_S_AT, 209          0          _S_AT, 242          71_AT, 205067_AT, 2022          4_S_AT, 
               
               
                   
                   
                 236561_AT, 230360_AT, 202859_X_AT, 1569149_AT, 20          _S_AT, 216017_S_AT, 204620_S_AT, 
               
               
                   
                   
                 212099_AT, 201147_S_AT, 201565_S_AT, 201590_X_AT, 232          49_AT, 204653_AT, 203104_AT, 
               
               
                   
                   
                 225115_AT, 1555          32_S_AT, 210845_S_AT, 243556_AT, 201005_AT, 208961_S_AT, 233220_AT, 
               
               
                   
                   
                 210095_S_AT, 237252_AT, 160020_AT, 224967_AT, 216248_S_AT, 234297_AT, 212171_X_AT, 
               
               
                   
                   
                 39402_AT, 2054          3_S_AT, 201566_X_AT, 214          66_AT, 22          964_AT, 202191_S_AT, 229          30_AT, 
               
               
                   
                   
                 1557905_S_AT, 21          502_S_AT, 206          35_AT, 222670_S_AT, 201150_S_AT, 20          751_X_AT, 20114          _S_AT, 
               
               
                   
                   
                 1554992_AT, 202768_AT, 2132          1_AT, 224606_AT, 204619_S_AT, 2156          6_S_AT, 210513_S_AT, 
               
               
                   
                   
                 1554600_S_AT, 204105_S_AT, 204          1_S_AT, 225097_AT, 20          752_S_AT, 212          03_AT, 225557_AT, 
               
               
                   
                   
                 217279_X_AT, 217591_AT, 37152_AT, 201069_AT, 221841_S_AT, 211924_S_AT, 224218_S_AT, 
               
               
                   
                   
                 222877_AT, 24193          _AT, 213763_AT, 211962_S_AT, 1566901_AT, 200          _AT, 204141_AT, 
               
               
                   
                   
                 204736_S_AT, 203665_AT, 204490_S_AT, 204998_S_AT, 208816_X_AT, 201149_S_AT, 239519_AT, 
               
               
                   
                   
                 209          35_X_AT, 225116_AT, 232150_AT, 201466_S_AT, 212143_S_AT, 204035_AT, 2120          6_X_AT, 
               
               
                   
                   
                 2204          4_AT, 203          7_S_AT, 212134_AT, 225368_AT, 208937_S_AT, 228762_AT, 222651_S_AT, 
               
               
                   
                   
                 2219          _AT, 230529_AT, 201324_AT, 201012_AT, 202539_S_AT, 213503_X_AT, 204622_X_AT, 
               
               
                   
                   
                 227240_AT, 241722_X_AT, 210427_X_AT, 214724_AT, 22621          _AT, 218559_S_AT, 2026          6_S_AT, 
               
               
                   
                   
                 204684_AT, 219          45_AT, 219906_AT, 202          27_S_AT, 210512_S_AT, 223092_AT, 205419_AT, 
               
               
                   
                   
                 211527_X_AT, 1562467_AT, 204465_S_AT, 203140_AT, 220266_S_AT, 220935_S_AT, 209189_AT, 
               
               
                   
                   
                 212372_AT, 203          _AT, 203935_AT, 2120          9_AT, 201996_AT, 227697_AT, 229797_AT, 203411_S_AT, 
               
               
                   
                   
                 210173_AT, 211571_S_AT, 2136          _AT, 203320_AT 
               
               
                   
                 GOTERM —   
                 202540_S_AT, 210495_X_AT, 229221_AT, 37152_AT, 212298_AT, 212014_X_AT, 211924_S_AT, 
               
               
                   
                 BP_ALL 
                 221732_X_AT, 222877_AT, 210915_S_AT, 204268_AT, 235735_AT, 223220_S_AT, 202          2          _S_AT, 
               
               
                   
                   
                 205067_AT, 202859_X_AT, 236561_AT, 209          27_S_AT, 204489_S_AT, 204490_S_AT, 204620_S_AT, 
               
               
                   
                   
                 239519_AT, 209835_X_AT, 204035_AT, 208937_S_AT, 209392_AT, 210          45_S_AT, 202539_S_AT, 
               
               
                   
                   
                 212464_S_AT, 160020_AT, 216442_X_AT, 216248_S_AT, 39402_AT, 204622_X_AT, 2054          3_S_AT, 
               
               
                   
                   
                 1405_I_AT, 214          66_AT, 211719_X_AT, 229          30_AT, 205099_S_AT, 211661_X_AT, 1557935_S_AT, 
               
               
                   
                   
                 200921_S_AT, 202827_S_AT, 221463_AT, 200920_S_AT, 210839_S_AT, 209906_AT, 204655_AT, 
               
               
                   
                   
                 21564          _S_AT, 204619_S_AT, 212372_AT, 20          35_AT, 204105_S_AT, 1555759_A_AT, 217279_X_AT, 
               
               
                   
                   
                 211571_S_AT, 205098_AT 
               
               
                   
                 GOTERM —   
                 202540_S_AT, 201464_X_AT, 210495_X_AT, 201465_S_AT, 229221_AT, 227069_AT, 219028_AT, 
               
               
                   
                 BP_ALL 
                 210136_AT, 212298_AT, 212014_X_AT, 221731_X_AT, 221011_S_AT, 201473_AT, 210916_S_AT, 
               
               
                   
                   
                 201471_S_AT, 235739_AT, 206472_S_AT, 208960_S_AT, 202828_S_AT, 205067_AT, 242871_AT, 
               
               
                   
                   
                 209          03_S_AT, 226648_AT, 2022          4_S_AT, 202          59_X_AT, 230360_AT, 236561_AT, 156          149_AT, 
               
               
                   
                   
                 204489_S_AT, 216017_S_AT, 208891_AT, 204620_S_AT, 212099_AT, 201565_S_AT, 201147_S_AT, 
               
               
                   
                   
                 201590_X_AT, 232649_AT, 204653_AT, 203104_AT, 225115_AT, 1555          32_S_AT, 210845_S_AT, 
               
               
                   
                   
                 243556_AT, 201005_AT, 20          961_S_AT, 233220_AT, 210095_S_AT, 237252_AT, 160020_AT, 
               
               
                   
                   
                 214297_AT, 212171_X_AT, 216248_S_AT, 224967_AT, 39402_AT, 205463_S_AT, 1405_I_AT, 
               
               
                   
                   
                 201566_X_AT, 22          964_AT, 211719_X_AT, 214          66_AT, 202191_AT, 229          30_AT, 1557905_S_AT, 
               
               
                   
                   
                 21          502_S_AT, 206835_AT, 222670_S_AT, 203751_X_AT, 201150_S_AT, 201148_S_AT, 155          992_AT, 
               
               
                   
                   
                 202768_AT, 2132          1_AT, 224606_AT, 204619_S_AT, 215646_S_AT, 210613_S_AT, 1554600_S_AT, 
               
               
                   
                   
                 23          669_AT, 204105_S_AT, 204          1_S_AT, 225097_AT, 20          752_S_AT, 212803_AT, 225557_AT, 
               
               
                   
                   
                 217591_AT, 217279_X_AT, 37152_AT, 201069_AT, 221841_S_AT, 211924_S_AT, 224218_S_AT, 
               
               
                   
                   
                 222          77_AT, 24193          _AT, 213763_AT, 211962_S_AT, 1566001_AT, 200          78_AT, 204141_AT, 202388_AT, 
               
               
                   
                   
                 20          736_S_AT, 203665_AT, 204490_S_AT, 20499          _S_AT, 20          16_X_AT, 201149_S_AT, 23          19_AT, 
               
               
                   
                   
                 209835_X_AT, 225116_AT, 212190_AT, 201466_S_AT, 212143_S_AT, 204035_AT, 2120          _X_AT, 
               
               
                   
                   
                 220484_AT, 203887_S_AT, 212124_AT, 225368_AT, 208537_S_AT, 228762_AT, 222651_S_AT, 
               
               
                   
                   
                 230529_AT, 211986_AT, 201324_AT, 202539_S_AT, 301012_AT, 212464_S_AT, 216442_X_AT, 
               
               
                   
                   
                 213503_X_AT, 204622_X_AT, 227240_AT, 241722_X_AT, 210427_X_AT, 214724_AT, 226218_AT, 
               
               
                   
                   
                 218559_S_AT, 202686_S_AT, 204684_AT, 20          _S_AT, 219          45_AT, 21990          _AT, 223092_AT, 
               
               
                   
                   
                 210512_S_AT, 202827_S_AT, 205419_AT, 211527_X_AT, 1562467_AT, 204465_S_AT, 203140_AT, 
               
               
                   
                   
                 20          92_S_AT, 220266_S_AT, 220935_S_AT, 204655_AT, 2091          9_AT, 203          _AT, 212372_AT, 
               
               
                   
                   
                 203935_AT, 212089_AT, 227637_AT, 201995_AT, 229797_AT, 1555759_A_AT, 203411_S_AT, 
               
               
                   
                   
                 210173_AT, 211571_S_AT, 2156          8_AT, 203320_AT 
               
               
                   
                 GOTERM —   
                 160020_AT, 3          402_AT, 2054          3_S_AT, 216243_S_AT, 1405_I_AT, 201473_AT, 229          30_AT, 
               
               
                   
                 BP_ALL 
                 201041_S_AT, 212657_S_AT, 202          28_S_AT, 205067_AT, 2022          4_S_AT, 202827_S_AT, 236561_AT, 
               
               
                   
                   
                 209047_AT, 201150_S_AT, 217173_S_AT, 201148_S_AT, 203665_AT, 217757_AT, 204655_AT, 
               
               
                   
                   
                 201149_S_AT, 2091          _AT, 201147_S_AT, 202068_S_AT, 201044_X_AT, 23          669_AT, 201313_AT, 
               
               
                   
                   
                 227697_AT, 1555759_A_AT, 217279_X_AT, 202067_S_AT, 207819_S_AT 
               
               
                   
                 GOTERM —   
                 237252_AT, 216442_X_AT, 210495_X_AT, 201069_AT, 212171_X_AT, 39402_AT, 205463_S_AT, 
               
               
                   
                 CC_ALL 
                 216243_S_AT, 1405_I_AT, 211719_X_AT, 223501_AT, 229830_AT, 212657_S_AT, 203940_S_AT, 
               
               
                   
                   
                 227265_AT, 23          542_AT, 203548_S_AT, 205067_AT, 219908_AT, 210512_S_AT, 202          59_X_AT, 
               
               
                   
                   
                 221463_AT, 226545_AT, 211527_X_AT, 209827_S_AT, 217273_S_AT, 203665_AT, 217757_AT, 
               
               
                   
                   
                 204655_AT, 210513_S_AT, 202068_S_AT, 21219_AT, 223502_S_AT, 203          8_AT, 212143_S_AT, 
               
               
                   
                   
                 204035_AT, 203887_S_AT, 202756_S_AT, 204          34_AT, 205495_S_AT, 1555759_A_AT, 216546_S_AT, 
               
               
                   
                   
                 202067_S_AT, 210095_S_AT, 212464_S_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 202540_S_AT, 210495_X_AT, 227069_AT, 229221_AT, 201465_S_AT, 210136_AT, 
               
               
                   
                 BP_ALL 
                 212298_AT, 212014_X_AT, 221731_X_AT, 201473_AT, 210916_S_AT, 235739_AT, 206472_S_AT, 
               
               
                   
                   
                 20          960_S_AT, 202          2          _S_AT, 205067_AT, 209          03_S_AT, 236561_AT, 230360_AT, 202859_X_AT, 
               
               
                   
                   
                 202284_S_AT, 156          149_AT, 204489_S_AT, 21          017_S_AT, 204620_S_AT, 212099_AT, 201147_S_AT, 
               
               
                   
                   
                 201565_S_AT, 201590_X_AT, 232649_AT, 204653_AT, 1555832_S_AT, 210845_S_AT, 243          6_AT, 
               
               
                   
                   
                 201005_AT, 208961_S_AT, 233220_AT, 2100          5_S_AT, 250020_AT, 224967_AT, 21624          _S_AT, 
               
               
                   
                   
                 214297_AT, 212171_X_AT, 39402_AT, 205463_S_AT, 201566_X_AT, 214866_AT, 228964_AT, 
               
               
                   
                   
                 211719_X_AT, 202191_S_AT, 229830_AT, 1557905_S_AT, 21          502_S_AT, 206835_AT, 222670_S_AT, 
               
               
                   
                   
                 201150_S_AT, 203751_X_AT, 20114          _S_AT, 1554992_AT, 2132          1_AT, 224          06_AT, 20461          _S_AT, 
               
               
                   
                   
                 215646_S_AT, 210513_S_AT, 1554600_S_AT, 204105_S_AT, 204          1_S_AT, 203752_S_AT, 212          03_AT, 
               
               
                   
                   
                 225557_AT, 217279_X_AT, 37152_AT, 201069_AT, 221          41_S_AT, 211924_S_AT, 224218_S_AT, 
               
               
                   
                   
                 222877_AT, 241938_AT, 211962_AT, 1566901_AT, 200          7          _AT, 204141_AT, 204736_S_AT, 
               
               
                   
                   
                 203665_AT, 204490_S_AT, 204998_S_AT, 20          16_X_AT, 20114          _S_AT, 239519_AT,           09          35_X_AT, 
               
               
                   
                   
                 212190_AT, 201466_S_AT, 212143_S_AT, 204035_AT, 2120          6_X_AT, 220484_AT, 212124_AT, 
               
               
                   
                   
                 20          37_S_AT, 22          762_AT, 222651_S_AT, 211986_AT, 230529_AT, 201324_AT, 201012_AT, 
               
               
                   
                   
                 202539_S_AT, 212464_S_AT, 216442_X_AT, 213503_X_AT, 204622_X_AT, 227240_AT, 210427_X_AT 
               
               
                   
                   
                 226218_AT, 218559_S_AT, 2026          6_S_AT, 2046          4_AT, 2198          5_AT, 210512_S_AT, 223092_AT, 
               
               
                   
                   
                 202          27_S_AT, 205419_AT, 211527_X_AT, 1562467_AT, 204465_S_AT, 203140_AT, 220266_S_AT, 
               
               
                   
                   
                 220935_S_AT, 209189_AT, 212372_AT, 203935_AT, 2120          _AT, 201995_AT, 2276          7_AT, 229797_AT, 
               
               
                   
                   
                 203411_S_AT, 210173_AT, 212571_S_AT, 2156          _AT, 203          0_AT 
               
               
                   
                 GOTERM —   
                 21902          _AT, 212171_X_AT, 213503_X_AT, 39402_AT, 205463_S_AT, 227948_AT, 1405_I_AT, 
               
               
                   
                 BP_ALL 
                 210427_X_AT, 226218_AT, 223501_AT, 229830_AT, 204923_AT, 213763_AT, 222062_AT, 205067_AT, 
               
               
                   
                   
                 210512_S_AT, 202          59_X_AT, 217552_X_AT, 208436_S_AT, 220066_AT, 211527_X_AT, 209827_S_AT, 
               
               
                   
                   
                 203939_AT, 201925_S_AT, 209906_AT, 203665_AT, 205          91_AT, 20          140_AT, 217757_AT, 
               
               
                   
                   
                 20          16_X_AT, 204655_AT, 210513_S_AT, 201590_X_AT, 225116_AT, 223502_S_AT, 1552914_A_AT, 
               
               
                   
                   
                 204035_AT, 225115_AT, 203233_AT, 2276          7_AT, 225097_AT, 203508_AT, 225368_AT, 155575          _A_AT, 
               
               
                   
                   
                 224859_AT, 233220_AT 
               
               
                   
                 GOTERM —   
                 210136_AT, 205552_S_AT, 204972_AT, 216243_S_AT, 216834_AT, 203923_S_AT, 201471_S_AT, 
               
               
                   
                 BP_ALL 
                 207674_AT, 212657_S_AT, 20          960_S_AT, 205067_AT, 202859_X_AT, 236561_AT, 220066_AT, 
               
               
                   
                   
                 209827_S_AT, 200          78_AT, 201925_S_AT, 202748_AT, 211307_S_AT, 201565_S_AT, 203922_S_AT, 
               
               
                   
                   
                 229937_X_AT, 223502_S_AT, 206157_AT, 1552914_A_AT, 204035_AT, 1555832_S_AT, 203508_AT, 
               
               
                   
                   
                 2029          _S_AT, 209392_AT, 224859_AT, 208961_S_AT, 242907_AT, 213293_S_AT, 214211_AT, 
               
               
                   
                   
                 212171_X_AT, 39402_AT, 210233_AT, 1405_I_AT, 201566_X_AT, 209949_AT, 226218_AT, 223501_AT, 
               
               
                   
                   
                 200748_S_AT, 205099_S_AT, 211661_X_AT, 22262_AT, 219          45_AT, 23          542_AT, 210512_S_AT, 
               
               
                   
                   
                 217552_X_AT, 221453_AT, 217078_S_AT, 205419_AT, 211527_X_AT, 23          581_AT, 210839_S_AT, 
               
               
                   
                   
                 209906_AT, 203140_AT, 224606_AT, 204655_AT, 210513_S_AT, 203233_AT, 1555759_A_AT, 
               
               
                   
                   
                 219434_AT, 203320_AT, 2050          _AT 
               
               
                   
                 GOTERM —   
                 160020_AT, 210495_X_AT, 216442_X_AT, 229221_AT, 201069_AT, 212171_X_AT, 213503_X_AT, 
               
               
                   
                 CC_ALL 
                 212014_X_AT, 210427_X_AT, 21719_X_AT, 221731_X_AT, 210916_S_AT, 1557905_S_AT, 
               
               
                   
                   
                 202828_S_AT, 215944_AT, 203548_S_AT, 210512_S_AT, 202827_S_AT, 211527_X_AT, 204475_AT, 
               
               
                   
                   
                 201150_S_AT, 20114          _S_AT, 204489_S_AT, 213428_S_AT, 204358_AT, 204490_S_AT, 208816_X_AT, 
               
               
                   
                   
                 204620_S_AT, 229004_AT, 201149_S_AT, 210513_S_AT, 201147_S_AT, 215646_S_AT, 204619_S_AT, 
               
               
                   
                   
                 209835_X_AT, 201590_X_AT, 202756_S_AT, 22          73_AT, 226546_S_AT, 217279_X_AT, 211571_S_AT, 
               
               
                   
                   
                 212          4_S_AT 
               
               
                   
                 GOTERM —   
                 160020_AT, 201464_X_AT, 201465_S_AT, 214297_AT, 212298_AT, 213503_X_AT, 212171_X_AT, 
               
               
                   
                 BP_ALL 
                 39402_AT, 205463_S_AT, 210427_X_AT, 222877_AT, 229830_AT, 202828_S_AT, 205067_AT, 
               
               
                   
                   
                 202827_S_AT, 202859_X_AT, 210512_S_AT, 211527_X_AT, 200          78_AT, 203665_AT, 204736_S_AT, 
               
               
                   
                   
                 2132          1_AT, 212099_AT, 208816_X_AT, 239519_AT, 210513_S_AT, 201590_X_AT, 2014          6_S_AT, 
               
               
                   
                   
                 20          35_AT, 204035_AT, 20          37_S_AT, 217279_X_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 237252_AT, 201465_S_AT, 39402_AT, 1405_I_AT, 20270          _S_AT, 202086_AT, 
               
               
                   
                 BP_ALL 
                 211661_X_AT, 222062_AT, 203882_AT, 239818_X_AT, 205067_AT, 220066_AT, 208436_S_AT, 
               
               
                   
                   
                 214453_S_AT, 202241_AT, 213281_AT, 204655_AT, 209189_AT, 1552553_A_AT, 211676_S_AT, 
               
               
                   
                   
                 229937_X_AT, 201466_S_AT, 206157_AT, 203          _AT, 227697_AT, 203          7_S_AT, 205495_S_AT, 
               
               
                   
                   
                 1555759_A_AT, 20843          _S_AT, 213293_S_AT 
               
               
                   
                 GOTERM —   
                 202540_S_AT, 160020_AT, 229221_AT, 210495_X_AT, 216442_X_AT, 37152_AT, 212298_AT, 
               
               
                   
                 BP_ALL 
                 21624          _S_AT, 39402_AT, 204622_X_AT, 1405_I_AT, 212014_X_AT, 221731_X_AT, 211719_X_AT, 
               
               
                   
                   
                 222          77_AT, 210916_S_AT, 204268_AT, 235739_AT, 223220_S_AT, 1557905_S_AT, 200921_S_AT, 
               
               
                   
                   
                 202          28_S_AT, 205067_AT, 202          59_X_AT, 202827_S_AT, 236561_AT, 200920_S_AT, 209827_S_AT 
               
               
                   
                   
                 2044          _S_AT, 204490_S_AT, 204620_S_AT, 204655_AT, 239519_AT, 204619_S_AT, 215646_S_AT, 
               
               
                   
                   
                 209835_X_AT, 212372_AT, 204035_AT, 203          5_AT, 204205_S_AT, 208937_S_AT, 1555759_A_AT, 
               
               
                   
                   
                 217279_X_AT, 211571_S_AT, 202539_S_AT, 212464_S_AT 
               
               
                   
                 GOTERM —   
                 202540_S_AT, 223723_AT, 227069_AT, 219028_AT, 212298_AT, 204872_AT, 212014_X_AT, 221731_X_AT, 216          34_AT, 
               
               
                   
                 CC_ALL 
                 203923_S_AT, 219412_AT, 207674_AT, 217997_AT, 209          03_S_AT, 23          681_AT, 228648_AT, 226545_AT, 203729_AT, 
               
               
                   
                   
                 217173_S_AT, 2044          9_S_AT, 205505_AT, 204620_S_AT, 220307_AT, 223303_AT, 211307_S_AT, 2160          0_S_AT, 
               
               
                   
                   
                 201590_X_AT, 232649_AT, 203922_S_AT, 2186          6_S_AT, 221825_AT, 1552914_A_AT, 203104_AT, 223562_S_AT, 
               
               
                   
                   
                 202756_S_AT, 228766_AT, 224674_AT, 214211_AT, 214581_X_AT, 20          926_AT, 224967_AT, 63825_AT, 205463_S_AT, 
               
               
                   
                   
                 211719_X_AT, 209949_AT, 223501_AT, 229          30_AT, 205099_S_AT, 1557905_S_AT, 209670_AT, 215          36_S_AT, 235944_AT, 
               
               
                   
                   
                 23          542_AT, 217074_S_AT, 209047_AT, 240076_AT, 217996_AT, 1554992_AT, 221840_AT, 201626_AT, 219926_AT, 
               
               
                   
                   
                 211676_S_AT, 225          42_AT, 1554600_S_AT, 23          669_AT, 204257_AT, 203233_AT, 2249          9_AT, 204105_S_AT, 239761_AT, 
               
               
                   
                   
                 201243_S_AT, 204912_AT, 23863          _AT, 222          77_AT, 24193          _AT, 209079_X_AT, 212062_AT, 22          0          3_AT, 202434_S_AT, 
               
               
                   
                   
                 204222_S_AT, 2064          _S_AT, 220066_AT, 228640_AT, 205542_AT, 204359_AT, 203665_AT, 204736_S_AT, 205891_AT, 
               
               
                   
                   
                 20274          _AT, 208816_X_AT, 239519_AT, 209835_X_AT, 208161_S_AT, 218856_AT, 225116_AT, 204715_AT, 223502_S_AT, 
               
               
                   
                   
                 256345_AT, 2120          6_AT, 2239          9_AT, 203          7_S_AT, 2029          _S_AT, 204774_AT, 202539_S_AT, 227240_AT, 
               
               
                   
                   
                 210427_X_AT, 2621          _AT, 204661_AT, 20074          _S_AT, 225          09_AT, 204401_AT, 2026          6_S_AT, 222062_AT, 210512_S_AT, 
               
               
                   
                   
                 2251          _AT, 217552_X_AT, 211527_X_AT, 202071_AT, 224990_AT, 225325_AT, 220313_AT, 20571          _AT, 203935_AT, 
               
               
                   
                   
                 210258_AT, 15565          3_A_AT, 201995_AT, 229797_AT, 226302_AT, 203411_S_AT, 21017          _AT, 2156          _AT, 20509          _AT, 
               
               
                   
                   
                 2104          5_X_AT, 229221_AT, 210136_AT, 209555_S_AT, 202435_S_AT, 211066_X_AT, 216971_S_AT, 210916_S_AT, 
               
               
                   
                   
                 2244          0_S_AT, 219225_AT, 202828_S_AT, 214255_AT, 242871_AT, 236561_AT, 230360_AT, 201925_S_AT, 228490_AT, 
               
               
                   
                   
                 207610_S_AT, 212099_AT, 213577_AT, 229937_X_AT, 214830_AT, 227052_AT, 225115_AT, 212977_AT, 203508_AT, 
               
               
                   
                   
                 230925_AT, 210          45_S_AT, 243556_AT, 201005_AT, 206033_S_AT, 201242_S_AT, 233220_AT, 207819_S_AT, 242907_AT, 
               
               
                   
                   
                 209122_AT, 160020_AT, 237252_AT, 212171_X_AT, 214297_AT, 210133_AT, 22          910_AT, 214          66_AT, 205534_AT, 
               
               
                   
                   
                 34210_AT, 205566_AT, 209994_S_AT, 1552690_A_AT, 228754_AT, 21767          _AT, 205717_X_AT, 23          5          1_AT, 201739_AT, 
               
               
                   
                   
                 209906_AT, 20          218_AT, 210513_S_AT, 204619_S_AT, 215646_S_AT, 25920_AT, 211030_S_AT, 20          121_S_AT, 
               
               
                   
                   
                 235295_AT, 201313_AT, 239451_AT, 204881_S_AT, 225097_AT, 219994_AT, 217279_X_AT, 201125_S_AT, 201627_S_AT, 
               
               
                   
                   
                 201069_AT, 211924_S_AT, 203217_S_AT, 213763_AT, 206171_AT, 241954_AT, 203939_AT, 243          94_AT, 21342          _S_AT, 
               
               
                   
                   
                 202436_S_AT, 204490_S_AT, 219386_S_AT, 209921_AT, 225337_AT, 2204          4_AT, 209146_AT, 22536          _AT, 241773_AT, 
               
               
                   
                   
                 22          762_AT, 209392_AT, 224859_AT, 201625_S_AT, 201324_AT, 209993_AT, 201012_AT, 212464_S_AT, 216442_X_AT, 
               
               
                   
                   
                 2271          0_AT, 213503_X_AT, 241722_X_AT, 228708_AT, 214724_AT, 227107_AT, 211661_X_AT, 225207_AT, 226931_AT, 
               
               
                   
                   
                 2193          5_AT, 203548_S_AT, 202          27_S_AT, 223092_AT, 205419_AT,           7100_AT, 1562467_AT, 210          39_S_AT, 235299_AT, 
               
               
                   
                   
                 224701_AT, 219332_AT, 202437_S_AT, 20206          _S_AT, 212372_AT, 203          _AT, 22379          _AT, 212096_S_AT, 2120          9_AT, 
               
               
                   
                   
                 22          696_AT, 218223_S_AT, 241929_AT, 202067_S_AT, 219434_AT, 211571_S_AT 
               
               
                   
                 KEGG —   
                 214581_X_AT, 204912_AT, 212171_X_AT, 39402_AT, 205463_S_AT, 210233_AT, 1405_I_AT, 
               
               
                   
                 PATHWAY 
                 226218_AT, 223501_AT, 229830_AT, 205099_S_AT, 205067_AT, 202859_X_AT, 236561_AT, 
               
               
                   
                   
                 210512_S_AT, 221463_AT, 211527_X_AT, 204655_AT, 210513_S_AT, 211676_S_AT, 218856_AT, 
               
               
                   
                   
                 223502_S_AT, 203935_AT, 203104_AT, 203233_AT, 203508_AT, 204436_AT, 1555759_A_AT, 
               
               
                   
                   
                 205098_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 210495_X_AT, 229221_AT, 201465_S_AT, 201069_AT, 212298_AT, 221841_S_AT, 
               
               
                   
                 BP_ALL 
                 211924_S_AT, 212014_X_AT, 221731_X_AT, 201473_AT, 222877_AT, 241938_AT, 210916_S_AT, 
               
               
                   
                   
                 235739_AT, 206472_S_AT, 211962_S_AT, 202828_S_AT, 1556901_AT, 209803_S_AT, 205067_AT, 
               
               
                   
                   
                 202284_S_AT, 202859_X_AT, 236561_AT, 200878_AT, 204489_S_AT, 216017_AT, 203665_AT, 
               
               
                   
                   
                 204736_S_AT, 204490_S_AT, 204620_S_AT, 208816_X_AT, 212099_AT, 201149_S_AT, 201147_S_AT, 
               
               
                   
                   
                 239519_AT, 201590_X_AT, 209835_X_AT, 204653_AT, 201466_S_AT, 204035_AT, 212124_AT, 
               
               
                   
                   
                 208937_S_AT, 210845_S_AT, 228762_AT, 201005_AT, 212464_S_AT, 160020_AT, 216442_X_AT, 
               
               
                   
                   
                 216248_S_AT, 214297_AT, 213503_X_AT, 212171_X_AT, 39402_AT, 204622_X_AT, 205463_S_AT, 
               
               
                   
                   
                 210427_X_AT, 214866_AT, 211719_X_AT, 226218_AT, 229830_AT, 202191_S_AT, 218559_S_AT, 
               
               
                   
                   
                 1557905_S_AT, 202686_S_AT, 202827_S_AT, 222670_S_AT, 210512_S_AT, 211527_X_AT, 
               
               
                   
                   
                 201150_S_AT, 204465_S_AT, 201148_S_AT, 203140_AT, 220266_S_AT, 213281_AT, 215646_S_AT, 
               
               
                   
                   
                 204619_S_AT, 210513_S_AT, 212372_AT, 203935_AT, 204105_S_AT, 227697_AT, 201995_AT, 
               
               
                   
                   
                 212803_AT, 225557_AT, 210173_AT, 217279_X_AT, 211571_S_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 201465_S_AT, 229221_AT, 202435_S_AT, 216243_S_AT, 212014_X_AT, 201473_AT, 
               
               
                   
                 BP_ALL 
                 210916_S_AT, 235739_AT, 202828_S_AT, 205067_AT, 202859_X_AT, 236561_AT, 202284_S_AT, 
               
               
                   
                   
                 209827_S_AT, 217173_S_AT, 204489_S_AT, 201565_S_AT, 201147_S_AT, 213577_AT, 213562_S_AT, 
               
               
                   
                   
                 210845_S_AT, 201242_S_AT, 233220_AT, 207819_S_AT, 209122_AT, 237252_AT, 160020_AT, 
               
               
                   
                   
                 212171_X_AT, 216248_S_AT, 39402_AT, 205463_S_AT, 1405_I_AT, 201566_X_AT, 214866_AT, 
               
               
                   
                   
                 204058_AT, 229830_AT, 205099_S_AT, 209994_S_AT, 1557905_S_AT, 239818_X_AT, 217678_AT, 
               
               
                   
                   
                 209047_AT, 221463_AT, 201150_S_AT, 201148_S_AT, 209906_AT, 209218_AT, 204059_S_AT, 
               
               
                   
                   
                 217757_AT, 213281_AT, 210513_S_AT, 238669_AT, 235295_AT, 201313_AT, 239451_AT, 37028_AT, 
               
               
                   
                   
                 217279_X_AT, 201243_S_AT, 201069_AT, 221841_S_AT, 211924_S_AT, 222877_AT, 201041_S_AT, 
               
               
                   
                   
                 202434_S_AT, 212657_S_AT, 220066_AT, 202014_AT, 200878_AT, 203665_AT, 204490_S_AT, 
               
               
                   
                   
                 202436_S_AT, 201149_S_AT, 209835_X_AT, 209922_AT, 204715_AT, 201466_S_AT, 204035_AT, 
               
               
                   
                   
                 203887_S_AT, 208937_S_AT, 209392_AT, 209993_AT, 204622_X_AT, 241722_X_AT, 218934_S_AT, 
               
               
                   
                   
                 227107_AT, 211661_X_AT, 210512_S_AT, 202827_S_AT, 211527_X_AT, 1562467_AT, 210839_S_AT, 
               
               
                   
                   
                 220266_S_AT, 202241_AT, 204655_AT, 209189_AT, 202437_S_AT, 202068_S_AT, 201044_X_AT, 
               
               
                   
                   
                 203888_AT, 1556583_A_AT, 227697_AT, 1555759_A_AT, 202067_S_AT, 205098_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 201465_S_AT, 229221_AT, 202435_S_AT, 216243_S_AT, 212014_X_AT, 201473_AT, 
               
               
                   
                 BP_ALL 
                 210916_S_AT, 201041_S_AT, 235739_AT, 202434_S_AT, 212657_S_AT, 202828_S_AT, 205067_AT, 
               
               
                   
                   
                 202284_S_AT, 236561_AT, 220066_AT, 202014_AT, 217173_S_AT, 204489_S_AT, 203665_AT, 
               
               
                   
                   
                 204490_S_AT, 202436_S_AT, 201149_S_AT, 201147_S_AT, 201565_S_AT, 209835_X_AT, 213577_AT, 
               
               
                   
                   
                 204715_AT, 201466_S_AT, 213562_S_AT, 203887_S_AT, 208937_S_AT, 233220_AT, 207819_S_AT, 
               
               
                   
                   
                 209122_AT, 160020_AT, 237252_AT, 216248_S_AT, 39402_AT, 205463_S_AT, 204622_X_AT, 
               
               
                   
                   
                 241722_X_AT, 1405_I_AT, 201566_X_AT, 218934_S_AT, 204058_AT, 229830_AT, 227107_AT, 
               
               
                   
                   
                 211661_X_AT, 1557905_S_AT, 239818_X_AT, 202827_S_AT, 209047_AT, 1563467_AT, 201150_S_AT, 
               
               
                   
                   
                 201148_S_AT, 209218_AT, 204059_S_AT, 217757_AT, 213281_AT, 202241_AT, 204655_AT, 
               
               
                   
                   
                 209189_AT, 202437_S_AT, 202068_S_AT, 201044_X_AT, 238669_AT, 203888_AT, 235295_AT, 
               
               
                   
                   
                 201313_AT, 1556583_A_AT, 227697_AT, 37028_AT, 1555759_A_AT, 217279_X_AT, 202067_S_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 202540_S_AT, 229221_AT, 227069_AT, 201465_S_AT, 212298_AT, 212014_X_AT, 
               
               
                   
                 BP_ALL 
                 201473_AT, 210916_S_AT, 208960_S_AT, 206472_S_AT, 202828_S_AT, 205067_AT, 209803_S_AT, 
               
               
                   
                   
                 236561_AT, 202859_X_AT, 202284_S_AT, 204489_S_AT, 216017_S_AT, 212099_AT, 201565_S_AT, 
               
               
                   
                   
                 201147_S_AT, 201590_X_AT, 204653_AT, 1555832_S_AT, 210845_S_AT, 208961_S_AT, 160020_AT, 
               
               
                   
                   
                 212171_X_AT, 214297_AT, 224967_AT, 39402_AT, 205463_S_AT, 201566_X_AT, 228964_AT, 
               
               
                   
                   
                 214866_AT, 229830_AT, 1557905_S_AT, 206835_AT, 222670_S_AT, 201150_S_AT, 201148_S_AT, 
               
               
                   
                   
                 213281_AT, 224606_AT, 210513_S_AT, 1554600_S_AT, 204881_S_AT, 212803_AT, 225557_AT, 
               
               
                   
                   
                 217279_X_AT, 201069_AT, 37152_AT, 221841_S_AT, 211924_S_AT, 222877_AT, 241938_AT, 
               
               
                   
                   
                 211962_S_AT, 1566901_AT, 200878_AT, 204736_S_AT, 203665_AT, 204490_S_AT, 208816_X_AT, 
               
               
                   
                   
                 201149_S_AT, 239519_AT, 209835_X_AT, 201466_S_AT, 204035_AT, 212086_X_AT, 220484_AT, 
               
               
                   
                   
                 212124_AT, 208937_S_AT, 228762_AT, 230529_AT, 201324_AT, 202539_S_AT, 201012_AT, 
               
               
                   
                   
                 213503_X_AT, 210427_X_AT, 226218_AT, 218559_S_AT, 202686_S_AT, 219845_AT, 210512_S_AT, 
               
               
                   
                   
                 202827_S_AT, 205419_AT, 211527_X_AT, 1562467_AT, 204465_S_AT, 203140_AT, 220255_S_AT, 
               
               
                   
                   
                 220935_S_AT, 212372_AT, 203935_AT, 212089_AT, 201995_AT, 227697_AT, 229797_AT, 
               
               
                   
                   
                 203411_S_AT, 210173_AT, 203320_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 213891_S_AT, 227069_AT, 201465_S_AT, 219028_AT, 212298_AT, 210136_AT, 
               
               
                   
                 BP_ALL 
                 216834_AT, 201471_S_AT, 235739_AT, 202828_S_AT, 205067_AT, 236561_AT, 202859_X_AT, 
               
               
                   
                   
                 202284_S_AT, 201170_S_AT, 203729_AT, 228490_AT, 216017_S_AT, 212099_AT, 201147_S_AT, 
               
               
                   
                   
                 201565_S_AT, 201590_X_AT, 203753_AT, 221815_AT, 1552914_A_AT, 225115_AT, 222146_S_AT, 
               
               
                   
                   
                 203508_AT, 205312_AT, 201005_AT, 233220_AT, 210095_S_AT, 214211_AT, 160020_AT, 
               
               
                   
                   
                 212171_X_AT, 216248_S_AT, 63825_AT, 39402_AT, 205463_S_AT, 1405_I_AT, 201566_X_AT, 
               
               
                   
                   
                 228964_AT, 223501_AT, 223398_AT, 229830_AT, 212387_AT, 205566_AT, 218502_S_AT, 206835_AT, 
               
               
                   
                   
                 239818_X_AT, 222670_S_AT, 208436_S_AT, 200920_S_AT, 201150_S_AT, 201148_S_AT, 202768_AT, 
               
               
                   
                   
                 217757_AT, 213281_AT, 210513_S_AT, 238669_AT, 203233_AT, 239451_AT, 212386_AT, 225097_AT, 
               
               
                   
                   
                 219257_S_AT, 212803_AT, 217591_AT, 217279_X_AT, 37152_AT, 221841_S_AT, 224218_S_AT, 
               
               
                   
                   
                 213763_AT, 1566901_AT, 220066_AT, 203939_AT, 202388_AT, 205891_AT, 203665_AT, 204998_S_AT, 
               
               
                   
                   
                 208816_X_AT, 201149_S_AT, 239519_AT, 225116_AT, 201466_S_AT, 223502_S_AT, 225337_AT, 
               
               
                   
                   
                 212143_S_AT, 204035_AT, 225368_AT, 202988_S_AT, 208937_S_AT, 222651_S_AT, 224859_AT, 
               
               
                   
                   
                 201012_AT, 205681_AT, 213503_X_AT, 204622_X_AT, 241722_X_AT, 210427_X_AT, 226218_AT, 
               
               
                   
                   
                 200748_S_AT, 218559_S_AT, 222062_AT, 203940_S_AT, 200921_S_AT, 219845_AT, 219908_AT, 
               
               
                   
                   
                 210512_S_AT, 202827_S_AT, 87100_AT, 211527_X_AT, 203140_AT, 220266_S_AT, 202241_AT, 
               
               
                   
                   
                 204655_AT, 203935_AT, 210258_AT, 227697_AT, 1555759_A_AT, 226302_AT, 223394_AT 
               
               
                   
                 GOTERM —   
                 205891_AT, 203140_AT, 212171_X_AT, 213503_X_AT, 217757_AT, 205463_S_AT, 208816_X_AT, 
               
               
                   
                 BP_ALL 
                 1405_I_AT, 204655_AT, 210513_S_AT, 210427_X_AT, 201590_X_AT, 229830_AT, 1552914_A_AT, 
               
               
                   
                   
                 204035_AT, 203508_AT, 210512_S_AT, 1555759_A_AT, 202859_X_AT, 211527_X_AT, 209827_S_AT, 
               
               
                   
                   
                 203939_AT, 224859_AT, 233220_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 210495_X_AT, 223723_AT, 201465_S_AT, 37152_AT, 210136_AT, 212298_AT, 
               
               
                   
                 BP_ALL 
                 209555_S_AT, 202435_S_AT, 227948_AT, 211924_S_AT, 203074_AT, 241938_AT, 202434_S_AT, 
               
               
                   
                   
                 206488_S_AT, 214255_AT, 205067_AT, 202284_S_AT, 236561_AT, 200878_AT, 201925_S_AT, 
               
               
                   
                   
                 201170_S_AT, 203729_AT, 217173_S_AT, 216017_S_AT, 205891_AT, 203665_AT, 202436_S_AT, 
               
               
                   
                   
                 208816_X_AT, 201565_S_AT, 239519_AT, 201590_X_AT, 201466_S_AT, 223502_S_AT, 215602_AT, 
               
               
                   
                   
                 203887_S_AT, 228766_AT, 210845_S_AT, 241773_AT, 201005_AT, 201324_AT, 212464_S_AT, 
               
               
                   
                   
                 214211_AT, 237252_AT, 216442_X_AT, 213503_X_AT, 212171_X_AT, 39402_AT, 241722_X_AT, 
               
               
                   
                   
                 1405_I_AT, 201566_X_AT, 210427_X_AT, 214866_AT, 211719_X_AT, 226218_AT, 223501_AT, 
               
               
                   
                   
                 204661_AT, 202191_S_AT, 34210_AT, 200748_S_AT, 205099_S_AT, 204401_AT, 206835_AT, 
               
               
                   
                   
                 200921_S_AT, 235944_AT, 203548_S_AT, 210512_S_AT, 200920_S_AT, 208436_S_AT, 211527_X_AT, 
               
               
                   
                   
                 1562467_AT, 209906_AT, 1554992_AT, 203140_AT, 213281_AT, 204655_AT, 202437_S_AT, 
               
               
                   
                   
                 210513_S_AT, 202068_S_AT, 1565754_X_AT, 238669_AT, 212372_AT, 203888_AT, 1565752_AT, 
               
               
                   
                   
                 239451_AT, 1556583_A_AT, 219257_S_AT, 212803_AT, 1555759_A_AT, 241929_AT, 202067_S_AT, 
               
               
                   
                   
                 215688_AT, 205098_AT, 223394_AT 
               
               
                   
                 GOTERM —   
                 160020_AT, 210495_X_AT, 216442_X_AT, 201069_AT, 212171_X_AT, 213503_X_AT, 210427_X_AT, 
               
               
                   
                 CC_ALL 
                 211719_X_AT, 221731_X_AT, 202828_S_AT, 235944_AT, 210512_S_AT, 202827_S_AT, 211527_X_AT, 
               
               
                   
                   
                 204475_AT, 201150_S_AT, 201148_S_AT, 213428_S_AT, 204359_AT, 204620_S_AT, 229004_AT, 
               
               
                   
                   
                 208816_X_AT, 201149_S_AT, 210513_S_AT, 201147_S_AT, 215646_S_AT, 204619_S_AT, 201590_X_AT, 
               
               
                   
                   
                 202756_S_AT, 228873_AT, 216546_S_AT, 217279_X_AT, 211571_S_AT, 212464_S_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 160020_AT, 201465_S_AT, 229221_AT, 201069_AT, 212171_X_AT, 213503_X_AT, 
               
               
                   
                 BP_ALL 
                 212298_AT, 214297_AT, 39402_AT, 205463_S_AT, 221841_S_AT, 212014_X_AT, 210427_X_AT, 
               
               
                   
                   
                 201473_AT, 222877_AT, 210916_S_AT, 229830_AT, 1557905_S_AT, 202828_S_AT, 1566901_AT, 
               
               
                   
                   
                 205067_AT, 210512_S_AT, 202827_S_AT, 202859_X_AT, 211527_X_AT, 200878_AT, 204489_S_AT, 
               
               
                   
                   
                 203665_AT, 204736_S_AT, 204490_S_AT, 220266_S_AT, 213281_AT, 212099_AT, 208816_X_AT, 
               
               
                   
                   
                 210513_S_AT, 239519_AT, 209835_X_AT, 201590_X_AT, 204653_AT, 201466_S_AT, 212372_AT, 
               
               
                   
                   
                 204035_AT, 203935_AT, 208937_S_AT, 217279_X_AT, 201005_AT 
               
               
                   
                 GOTERM —   
                 202540_S_AT, 160020_AT, 229221_AT, 210495_X_AT, 216442_X_AT, 37152_AT, 212298_AT, 
               
               
                   
                 BP_ALL 
                 216248_S_AT, 39402_AT, 204622_X_AT, 1405_I_AT, 212014_X_AT, 221731_X_AT, 211719_X_AT, 
               
               
                   
                   
                 222877_AT, 210916_S_AT, 204268_AT, 235739_AT, 223220_S_AT, 1557905_S_AT, 200921_S_AT, 
               
               
                   
                   
                 202828_S_AT, 205067_AT, 202859_X_AT, 202827_S_AT, 236561_AT, 200920_S_AT, 209827_S_AT, 
               
               
                   
                   
                 204489_S_AT, 204490_S_AT, 204620_S_AT, 204655_AT, 239519_AT, 204619_S_AT, 215646_S_AT, 
               
               
                   
                   
                 209835_X_AT, 212372_AT, 204035_AT, 203935_AT, 204105_S_AT, 208937_S_AT, 1555759_A_AT, 
               
               
                   
                   
                 217279_X_AT, 211571_S_AT, 202539_S_AT, 212464_S_AT 
               
               
                   
                 GOTERM —   
                 202540_S_AT, 160020_AT, 229221_AT, 210495_X_AT, 216442_X_AT, 37152_AT, 21229          _AT 
               
               
                   
                 BP_ALL 
                 216248_S_AT, 39402_AT, 204622_X_AT, 1405_I_AT, 212014_X_AT, 221731_X_AT, 211719_X_AT, 
               
               
                   
                   
                 222877_AT, 210916_S_AT, 204268_AT, 235739_AT, 223220_S_AT, 1557905_S_AT, 200921_S_AT, 
               
               
                   
                   
                 202          28_S_AT, 205067_AT, 202          59_X_AT, 202          27_S_AT, 236561_AT, 200920_S_AT, 209827_S_AT, 
               
               
                   
                   
                 204489_S_AT, 204490_S_AT, 204620_S_AT, 204655_AT, 239519_AT, 204615_S_AT, 215646_S_AT, 
               
               
                   
                   
                 209835_X_AT, 212372_AT, 204035_AT, 203935_AT, 204105_S_AT, 208937_S_AT, 1555759_A_AT, 
               
               
                   
                   
                 217279_X_AT, 211571_S_AT, 202539_S_AT, 212464_S_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 201465_S_AT, 37152_AT, 209555_S_AT, 39402_AT, 1405_I_AT, 201566_X_AT, 
               
               
                   
                 BP_ALL 
                 201473_AT, 226218_AT, 204923_AT, 206488_S_AT, 200921_S_AT, 1566901_AT, 205067_AT, 
               
               
                   
                   
                 203548_S_AT, 200920_S_AT, 15          9149_AT, 203751_X_AT, 2132          1_AT, 212099_AT, 204655_AT, 
               
               
                   
                   
                 201565_S_AT, 201466_S_AT, 212143_S_AT, 1552914_A_AT, 203935_AT, 204105_S_AT, 203233_AT, 
               
               
                   
                   
                 227697_AT, 228766_AT, 203752_AT, 219257_S_AT, 1555759_A_AT, 241929_AT, 224859_AT, 
               
               
                   
                   
                 210095_S_AT 
               
               
                   
                 GOTERM —   
                 202540_S_AT, 22          221_AT, 2270          _AT, 223723_AT, 2122          _AT, 20          55_S_AT, 212024_X_AT, 221731_X_AT, 
               
               
                   
                 CC_ALL 
                 20          23_S_AT, 212066_X_AT, 22091          _S_AT, 207          74_AT, 239225_AT, 2244          0_S_AT, 202828_S_AT, 2142          _AT, 
               
               
                   
                   
                 242          71_AT, 23          1_AT, 230          60_AT, 236561_AT, 226545_AT, 201          25_S_AT, 203729_AT, 227173_S_AT, 
               
               
                   
                   
                 2044          _S_AT, 22          90_AT, 202610_S_AT, 205505_AT, 220307_AT, 204          20_S_AT, 212099_AT, 211307_S_AT, 
               
               
                   
                   
                 21          0_S_AT, 232649_AT, 233577_AT, 203922_S_AT, 21          _S_AT, 229          37_X_AT, 221          15_AT, 214          0_AT, 
               
               
                   
                   
                 2270          2_AT, 1552          _A_AT, 20210          _AT, 213          62_S_AT, 212977_AT,           02754_S_AT, 22          6_AT, 20350          _AT, 
               
               
                   
                   
                 210          5_S_AT, 20          033_S_AT, 201005_AT, 201242_S_AT, 233220_AT, 207          _S_AT, 224674_AT, 2145          _X_AT, 
               
               
                   
                   
                 237252_AT, 160020_AT, 2142          7_AT, 224          67_AT,           3125_AT, 210          33_AT, 22          10_AT, 20          _AT, 214          _AT, 
               
               
                   
                   
                 223502_AT, 205534_AT, 34120_AT, 2050          _S_AT, 205566_AT, 200994_S_AT, 1552630_A_AT, 1557905_S_AT, 
               
               
                   
                   
                 22          754_AT, 209670_AT, 22          42_AT, 215          36_S_AT, 217          7          _AT, 205717_A_AT, 217078_S_AT, 240076_AT, 
               
               
                   
                   
                 209047_AT, 209906_AT, 20921          _AT, 221          40_AT, 204619_S_AT, 215616_S_AT, 201626_AT, 2120          0_S_AT, 
               
               
                   
                   
                 20          20_AT, 219926_AT, 20          121_S_AT, 21167          _S_AT, 2352          5_AT, 204257_AT, 203233_AT, 224          9_AT, 
               
               
                   
                   
                 204          05_S_AT, 20          81_S_AT, 201125_S_AT, 217279_X_AT, 20          677_S_AT, 23          762_AT, 201243_S_AT, 204912_AT, 
               
               
                   
                   
                 238          _AT, 211          24_S_AT, 222          77_AT, 203217_S_AT, 209019_X_AT, 212062_AT, 228083_AT, 204222_S_AT, 
               
               
                   
                   
                 20          88_S_AT, 20          171_AT, 2          2954_AT, 22          640_AT, 20          9_AT, 205542_AT, 24          _AT, 2042          _AT, 205          91_AT, 
               
               
                   
                   
                 2047          _S_AT, 2          4490_S_AT, 23          9_AT, 219          _S_AT, 20          35_X_AT, 208161_S_AT, 20          21_AT, 218856_AT, 
               
               
                   
                   
                 204715_AT, 223502_S_AT, 225337_AT, 236345_AT, 2204          4_AT, 203          7_S_AT, 22          _AT, 20          46_AT, 20          2_AT, 
               
               
                   
                   
                 2287          2_AT, 241773_AT, 224          _AT, 20          53_AT, 201324_AT, 201625_S_AT, 202          _S_AT, 204774_AT, 227180_AT, 
               
               
                   
                   
                 241722_X_AT, 22          70          _AT, 226228_AT, 20          61_AT, 225          09_AT, 227107_AT, 204401_AT, 2116          1_X_AT, 222062_AT, 
               
               
                   
                   
                 202          8_S_AT, 2269          1_AT, 21          85_AT, 20354          _S_AT, 22          0          2_AT, 217552_X_AT, 202          27_S_AT, 205419_AT, 
               
               
                   
                   
                            71          0_AT, 202071_AT, 2108          _S_AT, 22          90_AT, 235299_AT, 225325_AT, 2020          _S_AT, 220311_AT, 205714_AT, 
               
               
                   
                   
                 20          _AT, 20          5_AT, 2237          _AT, 2286          _AT, 201995_AT, 15565          3_A_AT, 22          297_AT, 226302_AT, 241          28_AT 
               
               
                   
                   
                 210173_AT,           020          7_S_AT, 215434_AT, 211572_S_AT, 2050          _AT 
               
               
                   
                 GOTERM —   
                 20          4          4_X_AT, 201465_S_AT, 229221_AT, 227069_AT, 210495_X_AT, 212296_AT, 210136_AT, 
               
               
                   
                 BP_ALL 
                 212014_X_AT, 221731_X_AT, 201473_AT, 210916_S_AT, 201471_S_AT, 235739_AT, 204960_S_AT, 
               
               
                   
                   
                 202828_S_AT, 242871_AT, 22          64          _AT, 236561_AT, 230360_AT, 156          149_AT, 20          9_S_AT, 
               
               
                   
                   
                 216017_S_AT, 208891_AT, 212099_AT, 204620_S_AT, 201565_S_AT, 232619_AT, 1555832_S_AT, 
               
               
                   
                   
                 243556_AT, 204961_S_AT, 210095_S_AT, 233220_AT, 160020_AT, 212171_X_AT, 214297_AT, 
               
               
                   
                   
                 21624          _S_AT, 201565_X_AT, 211719_X_AT, 228564_AT, 202191_S_AT, 1557505_S_AT, 201751_X_AT, 
               
               
                   
                   
                 155          92_AT, 213281_AT, 224606_AT, 215646_S_AT, 204619_S_AT, 210513_S_AT, 204105_S_AT, 
               
               
                   
                   
                 203752_S_AT, 212803_AT, 217279_X_AT, 37152_AT, 221841_S_AT, 221          77_AT, 24193          _AT, 
               
               
                   
                   
                 211          2_S_AT, 1566901_AT, 204141_AT, 200678_AT, 2023          _AT, 204736_S_AT, 204490_S_AT, 
               
               
                   
                   
                 2049          _S_AT, 239519_AT, 209835_X_AT, 212190_AT, 201466_S_AT, 212143_S_AT, 2204          4_AT, 
               
               
                   
                   
                 212124_AT, 201324_AT, 201012_AT, 212464_S_AT, 216          42_X_AT, 204622_X_AT, 241722_X_AT, 
               
               
                   
                   
                 227240_AT, 226218_AT, 208893_S_AT, 219          45_AT, 210512_S_AT, 202827_S_AT, 205419_AT, 
               
               
                   
                   
                 211917_X_AT, 1562467_AT, 204465_S_AT, 203240_AT, 208          2_S_AT, 2202          6_S_AT, 220935_S_AT, 
               
               
                   
                   
                 212372_AT, 201935_AT, 225797_AT, 210171_AT, 211571_S_AT, 203920_AT, 215          _AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 201465_S_AT, 219028_AT, 212298_AT, 216834_AT, 242794_AT, 213763_AT, 
               
               
                   
                 BP_ALL 
                 206472_S_AT, 203882_AT, 206171_AT, 226389_S_AT, 202859_X_AT, 236561_AT, 205891_AT, 
               
               
                   
                   
                 207610_S_AT, 239519_AT, 225126_AT, 201466_S_AT, 203104_AT, 225115_AT, 212977_AT, 
               
               
                   
                   
                 223939_AT, 203508_AT, 225368_AT, 202988_S_AT, 208937_S_AT, 209392_AT, 241773_AT, 
               
               
                   
                   
                 233220_AT, 201012_AT, 212171_AT, 205463_S_AT, 1405_I_AT, 235457_AT, 214724_AT, 226218_AT, 
               
               
                   
                   
                 229830_AT, 205099_S_AT, 211661_X_AT, 202686_S_AT, 222062_AT, 219908_AT, 210512_S_AT, 
               
               
                   
                   
                 228186_S_AT, 205419_AT, 211527_X_AT, 210839_S_AT, 244414_AT, 209906_AT, 242405_AT, 
               
               
                   
                   
                 213281_AT, 221840_AT, 204655_AT, 210513_S_AT, 209189_AT, 214054_AT, 203037_S_AT, 
               
               
                   
                   
                 220313_AT, 205718_AT, 225738_AT, 203935_AT, 210258_AT, 225097_AT, 219257_S_AT, 
               
               
                   
                   
                 1555759_A_AT, 210173_AT, 225557_AT, 201125_S_AT, 20509          _AT 
               
               
                   
                 GOTERM —   
                 204912_AT, 209555_S_AT, 217757_AT, 210233_AT, 211676_S_AT, 226218_AT, 205099_S_AT, 
               
               
                   
                 MF_ALL 
                 203104_AT, 203935_AT, 2064          _S_AT, 203233_AT, 222062_AT, 228766_AT, 203508_AT, 236361_AT, 
               
               
                   
                   
                 241929_AT, 205098_AT 
               
               
                   
                 GOTERM —   
                 237252.AT, 210495_X_AT, 216442_X_AT, 229221_AT, 37152_AT, 209555_S_AT, 39402_AT, 
               
               
                   
                 BP_ALL 
                 205463_S_AT, 211924_S_AT, 212014_X_AT, 214866_AT, 211719_X_AT, 203074_AT, 210916_S_AT, 
               
               
                   
                   
                 229830_AT, 206488_S_AT, 1557905_S_AT, 208960_S_AT, 235944_AT, 205067_AT, 201150_S_AT, 
               
               
                   
                   
                 204465_S_AT, 201148_S_AT, 204489_S_AT, 203665_AT, 204490_S_AT, 224606_AT, 201149_S_AT, 
               
               
                   
                   
                 201147_S_AT, 209835_X_AT, 212372_AT, 203888_AT, 203887_S_AT, 1555832_S_AT, 228766_AT, 
               
               
                   
                   
                 210845_S_AT, 241929_AT, 201005_AT, 208961_S_AT, 212464_S_AT 
               
               
                   
                 GOTERM —   
                 202540_S_AT, 210495_X_AT, 229221_AT, 37152_AT, 212298_AT, 212014_X_AT, 211924_S_AT, 
               
               
                   
                 BP_ALL 
                 221731_X_AT, 222877_AT, 210916_S_AT, 204268_AT, 235739_AT, 223220_S_AT, 202828_S_AT, 
               
               
                   
                   
                 205067_AT, 202859_X_AT, 236561_AT, 209827_S_AT, 204489_S_AT, 204490_S_AT, 204620_S_AT, 
               
               
                   
                   
                 239519_AT, 209835_X_AT, 204035_AT, 208937_S_AT, 209392_AT, 210845_S_AT, 201005_AT, 
               
               
                   
                   
                 202539_S_AT, 201012_AT, 212464_S_AT, 160020_AT, 216442_X_AT, 216248_S_AT, 39402_AT, 
               
               
                   
                   
                 204622_X_AT, 1405_I_AT, 211719_X_AT, 214866_AT, 1557905_S_AT, 200921_S_AT, 202827_S_AT, 
               
               
                   
                   
                 200920_S_AT, 210839_S_AT, 204655_AT, 215646_S_AT, 204619_S_AT, 203037_S_AT, 212372_AT, 
               
               
                   
                   
                 203935_AT, 204105_S_AT, 1555759_A_AT, 217279_X_AT, 211571_S_AT 
               
               
                   
                 GOTERM —   
                 210495_X_AT, 216442_X_AT, 210136_AT, 212171_X_AT, 212298_AT, 39402_AT, 227948_AT, 
               
               
                   
                 BP_ALL 
                 211719_X_AT, 202191_S_AT, 203940_S_AT, 200921_S_AT, 214255_AT, 205067_AT,210512_S_AT, 
               
               
                   
                   
                 200920_S_AT, 211527_X_AT, 203665_AT, 205891_AT, 212099_AT, 239519_AT, 210513_S_AT, 
               
               
                   
                   
                 1565754_X_AT, 212372_AT, 1565752_AT, 204105_S_AT, 215602_AT, 219257_S_AT, 208937_S_AT, 
               
               
                   
                   
                 212464_S_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 213          91_S_AT, 229221_AT, 201465_S_AT, 219028_AT, 212298_AT, 209555_S_AT, 
               
               
                   
                 BP_ALL 
                 212014_X_AT, 201473_AT, 211352_S_AT, 210916_S_AT, 201471_S_AT, 235739_AT, 234840_S_AT, 
               
               
                   
                   
                 205067_AT, 217997_AT, 236561_AT, 202859_X_AT, 2022          4_S_AT, 209          27_S_AT, 201925_S_AT, 
               
               
                   
                   
                 1569149_AT, 204489_S_AT, 212099_AT, 201147_S_AT, 201565_S_AT, 203753_AT, 207700_S_AT, 
               
               
                   
                   
                 1552914_A_AT, 225215_AT, 1555832_S_AT, 228766_AT, 222146_S_AT, 205312_AT, 243556_AT, 
               
               
                   
                   
                 20          961_S_AT, 210095_S_AT, 212171_X_AT, 216248_S_AT, 39402_AT, 205463_S_AT, 1405_I_AT, 
               
               
                   
                   
                 235457_AT, 201566_X_AT, 22          964_AT, 223501_AT, 229          10_AT, 212387_AT, 202086_AT, 
               
               
                   
                   
                 1557905_S_AT, 222670_S_AT, 200920_S_AT, 20          436_S_AT, 201150_S_AT, 203751_X_AT, 217996_AT, 
               
               
                   
                   
                 20114          _S_AT, 209906_AT, 1554992_AT, 2132          1_AT, 224606_AT, 210513_S_AT, 1565754_X_AT, 
               
               
                   
                   
                 225842_AT, 238669_AT, 2353295_AT, 1565752_AT, 203233_AT, 204105_S_AT, 212386_AT, 225097_AT, 
               
               
                   
                   
                 203752_S_AT, 219257_S_AT, 225557_AT, 37152_AT, 22794          _AT, 221841_S_AT, 242794_AT, 
               
               
                   
                   
                 21294          _AT, 204923_AT, 201041_S_AT, 206488_S_AT, 213763_AT, 1554453_AT, 1566901_AT, 
               
               
                   
                   
                 220066_AT, 20087          _AT, 205891_AT, 203663_AT, 204490_S_AT, 201149_S_AT, 239519_AT, 
               
               
                   
                   
                 209835_X_AT, 225116_AT, 204715_AT, 206157_AT, 201466_S_AT, 223502_S_AT, 212143_S_AT, 
               
               
                   
                   
                 204035_AT, 215602_AT, 212124_AT, 225368_AT, 241273_AT, 224859_AT, 218501_AT, 243797_AT, 
               
               
                   
                   
                 204622_X_AT, 227240_AT, 22621          _AT, 218559_S_AT, 227107_AT, 204401_AT, 222062_AT, 
               
               
                   
                   
                 200921_S_AT, 20354          _S_AT, 217552_X_AT, 210512_S_AT, 211527_X_AT, 244414_AT, 203140_AT, 
               
               
                   
                   
                 242405_AT, 220266_S_AT, 204655_AT, 1552553_A_AT, 2091          9_AT, 201044_X_AT, 203935_AT, 
               
               
                   
                   
                 227697_AT, 1555759_A_AT, 241929_AT, 215688_AT, 223394_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 201465_S_AT, 37152_AT, 20          555_S_AT, 1405_I_AT, 201565_X_AT, 201473_AT, 
               
               
                   
                 BP_ALL 
                 226218_AT, 204923_AT, 206488_S_AT, 200921_S_AT, 1566901_AT, 203548_S_AT, 200920_S_AT, 
               
               
                   
                   
                 203751_X_AT, 1569149_AT, 213281_AT, 204655_AT, 201565_S_AT, 201466_S_AT, 212143_S_AT, 
               
               
                   
                   
                 1552914_A_AT, 203935_AT, 203233_AT, 204205_S_AT, 227697_AT, 22          76          _AT, 203752_S_AT, 
               
               
                   
                   
                 1555759_A_AT, 241929_AT, 224859_AT, 210095_S_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 201465_S_AT, 229221_AT, 227069_AT, 210495_X_AT, 212298_AT, 210136_AT, 
               
               
                   
                 BP_ALL 
                 212014_X_AT, 221731_X_AT, 201473_AT, 210916_S_AT, 201471_S_AT, 235739_AT, 208960_S_AT, 
               
               
                   
                   
                 202828_S_AT, 242          71_AT, 22          648;_AT, 236561_AT, 230360_AT, 1569149_AT, 204489_S_AT, 
               
               
                   
                   
                 216017_S_AT, 208          91_AT, 212099_AT, 204620_S_AT, 201565_S_AT, 232649_AT, 1555          32_S_AT, 
               
               
                   
                   
                 201005_AT, 243556_AT, 208961_S_AT, 210095_S_AT, 233220_AT, 160020_AT, 214297_AT, 
               
               
                   
                   
                 212171_X_AT, 216248_S_AT, 201566_X_AT, 211719_X_AT, 228964_AT, 202193_S_AT, 1557905_S_AT, 
               
               
                   
                   
                 203751_X_AT, 1554992_AT, 213281_AT, 224606_AT, 215646_S_AT, 204619_S_AT, 210513_S_AT, 
               
               
                   
                   
                 204105_S_AT, 203752_S_AT, 212803_AT, 217279_X_AT, 37152_AT, 221          41_AT, 222          77_AT, 
               
               
                   
                   
                 24193          _AT, 211962_S_AT, 1566901_AT, 204141_AT, 200878_AT, 2025          _AT, 204736_S_AT, 
               
               
                   
                   
                 204490_S_AT, 2049          _S_AT, 239519_AT, 209835_X_AT, 212190_AT, 201466_S_AT, 212143_S_AT, 
               
               
                   
                   
                 220484_AT, 212124_AT, 201324_AT, 201012_AT, 212464_S_AT, 216          42_X_AT, 204622_X_AT, 
               
               
                   
                   
                 241722_X_AT, 227240_AT, 22621          _AT, 20889          _S_AT, 219          45_AT, 210512_S_AT, 202          27_S_AT, 
               
               
                   
                   
                 205419_AT, 211527_X_AT, 1562467_AT, 2044          5_S_AT, 203140_AT, 208          92_S_AT, 220266_S_AT, 
               
               
                   
                   
                 220935_S_AT, 212372_AT, 203935_AT, 229797_AT, 210173_AT, 211571_S_AT, 203320_AT, 215          _AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 201465_S_AT, 37152_AT, 212298_AT, 210136_AT, 209555_S_AT, 221841_S_AT, 
               
               
                   
                 BP_ALL 
                 1405_I_AT, 201566_X_AT, 201473_AT, 226218_AT, 218559_S_AT, 204923_AT, 206488_S_AT, 
               
               
                   
                   
                 200921_S_AT, 1566901_AT, 203548_S_AT, 236561_AT, 222670_S_AT, 200920_S_AT, 1569149_AT, 
               
               
                   
                   
                 203751_X_AT, 203140_AT, 220266_S_AT, 20499          _S_AT, 220935_S_AT, 213281_AT, 204655_AT, 
               
               
                   
                   
                 201565_S —— AT, 239519_AT, 201466_S_AT, 1552914_A_AT, 212143_S_AT, 2          3935_AT, 203233_AT, 
               
               
                   
                   
                 204105_S_AT, 227697_AT, 228766_AT, 203752_AT, 1555759_A_AT, 205312_AT, 241929_AT, 
               
               
                   
                   
                 224859_AT, 210095_S_AT 
               
               
                   
                 GOTERM —   
                 202540_S_AT, 202464_X_AT, 21          1_S_AT, 2014          5_S_AT, 223724_AT, 227069_AT, 21902          _AT, 2122          _AT, 212          14_X_AT, 
               
               
                   
                 BP_ALL 
                 216          34_AT, 22          412_AT, 20          60_S_AT, 217          97_AT, 205067_AT, 20          _X_AT, 201170_S_AT, 20          729_AT, 21712          _S_AT, 
               
               
                   
                   
                 2044          _S_AT, 216017_S_AT, 225171_AT, 220          07_AT, 202          _S_AT, 201147_S_AT, 201          0_X_AT, 230266_AT, 20          653_AT, 
               
               
                   
                   
                 221815_AT, 1552914_A_AT, 207700_S_AT, 202104_AT, 1555          2_S_AT, 204          _AT, 222144_S_AT, 2287          _AT, 2100          5_S_AT, 
               
               
                   
                   
                 214211_AT, 2145          1_X_AT, 2162          _S_AT, 6          25_AT, 205          3_S_AT, 140          _I_AT, 2015          _X_AT, 2          4_AT, 21171          _          _AT, 
               
               
                   
                   
                 22          03_AT, 2020          _AT, 2173          7_AT, 22          30_AT, 205099_S_AT, 1557905_S_AT, 21          02_S_AT, 20          5_AT, 235          4_AT, 
               
               
                   
                   
                 222          70_S_AT, 200          20_S_AT, 2191          3_S_AT, 20          _S_AT, 2278          _AT, 2087          _X_AT, 201150_S_AT, 20114          _S_AT, 1554          2_AT, 
               
               
                   
                   
                 217757_AT, 2132          1_AT, 15          5754_X_AT, 2295          _AT, 20          0          _AT, 211          _S_AT, 223          42_AT, 2257          _AT, 214250_S_AT, 
               
               
                   
                   
                 20          _AT, 23          _AT, 154          752_AT, 2032          _AT, 20420          _S_AT, 3702          _AT, 20          7          2_S_AT, 225557_AT, 2173          2_AT,           7152_AT, 
               
               
                   
                   
                 227943_AT, 242794_AT, 242          34_AT, 201041_S_AT, 204          23_AT, 202434_S_AT, 20          _S_AT, 212562_S_AT, 2251          _AT, 
               
               
                   
                   
                 2200          _AT, 200          78_AT, 225144_AT, 202          _AT, 205          1_AT, 2          65_AT, 204734_S_AT, 20          _X_AT, 2          1          _AT, 20          _X_AT, 
               
               
                   
                   
                 2          _AT, 225116_AT, 212180_AT, 20          715_AT, 20          4          _S_AT, 22          502_S_AT, 21214          _S_AT, 235602_AT, 22          _AT, 
               
               
                   
                   
                 2          67_S_AT, 202          _S_AT, 208          7_S_AT, 222          1_S_AT, 2025          _S_AT, 21          501_AT, 2          7          7_AT, 2272          0_AT, 210427_X_AT, 
               
               
                   
                   
                 22          21          _AT, 21          _S_AT, 204          61_AT, 200          _S_AT, 204401_AT, 20          _S_AT, 2220          2_AT, 22          _AT, 227          _AT, 21          _AT, 
               
               
                   
                   
                 220512_S_AT, 225          _AT, 217552_X_AT, 212527_X_AT, 202071_AT, 244424_AT, 203          40_AT, 20          52_S_AT, 220          _S_AT, 
               
               
                   
                   
                 242405_AT, 202241_AT, 201044_X_AT, 220313_AT, 20          _AT, 2102          _AT, 155636          _A_AT, 201          _AT, 22          302_AT, 215          _AT, 
               
               
                   
                   
                 2050          _AT, 210          _X_AT, 229225_AT, 210124_AT, 2          5_S_AT, 229155_AT, 202          _S_AT, 221011_S_AT, 20247          _AT, 
               
               
                   
                   
                 20247          _AT, 20          074_AT, 210916_S_AT, 211          2_X_AT, 1555          22_AT, 201471_S_AT, 2357          _AT, 204472_S_AT, 200          2_AT, 
               
               
                   
                   
                 226          _S_AT, 2244          _S_AT, 202          _S_AT, 214255_AT, 202          _S_AT, 2          1_AT, 20          27_A_AT, 201525_S_AT, 15          49_AT, 
               
               
                   
                   
                 22          90_AT, 207610_S_AT, 20          91_AT, 2120          _AT, 20          75          _AT, 1          2_A_AT, 225125_AT, 212          77_AT, 201          _AT, 20          312_AT, 
               
               
                   
                   
                 230          25_AT, 2          0          45_S_AT, 24          _AT, 201005_AT, 20          1_S_AT, 2          20_AT, 2132          _S_AT, 1500          _AT, 227252_AT, 
               
               
                   
                   
                 212171_X_AT, 2142          7_AT, 39402_AT, 21023          _AT, 2          457_AT, 214          66_AT, 23          _AT, 2021          1_S_AT, 34210_AT, 2          4_AT, 
               
               
                   
                   
                 205566_AT, 2          1          _X_AT, 221463_AT, 20          436_S_AT, 20          06_AT, 20276          _AT, 22          606_AT, 210513_S_AT, 2352          5_AT, 2          451_AT, 
               
               
                   
                   
                 200          72_AT, 212          5_AT, 22          0          7_AT, 21          257_S_AT, 21          4_AT, 222          03_AT, 21727          _X_AT, 221          41_S_AT, 234          _AT, 
               
               
                   
                   
                 211          24_AT, 2242          _S_AT, 212          _AT, 21          7          _AT, 240          6_AT, 204271_AT, 1554451_AT, 1555          01_AT, 1550          _AT, 
               
               
                   
                   
                 20101          _AT, 20          _AT, 2024          _S_AT, 2044          0_S_AT, 20          _S_AT, 20114          _S_AT, 236570_AT, 20          257_AT, 22          37_AT, 
               
               
                   
                   
                 2040          5_AT, 212224_AT, 2253          _AT, 200          7_AT, 24177          _AT, 224          _AT, 201324_AT, 200          1_AT, 201012_AT, 212          4_S_AT, 
               
               
                   
                   
                 216          2_X_AT, 21          50          _X_AT, 204622_X_AT, 242722_X_AT, 22          70          _AT, 21          _S_AT, 227107_AT, 221          1_X_AT, 20          0_S_AT, 
               
               
                   
                   
                 20          1_S_AT, 225207_AT, 200          25_S_AT, 20          _S_AT, 22          _AT, 202          27_S_AT, 20042          _AT,           7200_AT,           0039_S_AT, 
               
               
                   
                   
                 1542467_AT, 206571_S_AT, 22          _AT, 224702_AT, 220935_S_AT, 204          5_AT, 15          2553_A_AT, 202437_S_AT, 20          1          _AT, 
               
               
                   
                   
                 20          _S_AT, 2140          _AT, 20          0          7_S_AT, 212          72_AT, 203          _AT, 217272_S_AT, 227          7_AT, 15557          _A_AT, 241929_AT, 
               
               
                   
                   
                 2020          7_S_AT, 21943          _AT, 20          20_AT, 222          4_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 237252_AT, 201465_S_AT, 39402_AT, 1405_I_AT, 202708_S_AT, 218934_S_AT, 
               
               
                   
                 BP_ALL 
                 202086_AT, 211661_X_AT, 222062_AT, 203882_AT, 239818_X_AT, 205067_AT, 220066_AT, 
               
               
                   
                   
                 208436_S_AT, 202014_AT, 214453_S_AT, 202241_AT, 213281_AT, 204655_AT, 1552553_A_AT, 
               
               
                   
                   
                 209189_AT, 211676_S_AT, 229937_X_AT, 201466_S_AT, 206157_AT, 203888_AT, 227697_AT, 
               
               
                   
                   
                 203887_S_AT, 37028_AT, 205495_S_AT, 1555759_A_AT, 208438_S_AT, 213293_S_AT 
               
               
                   
                 GOTERM —   
                 202540_S_AT, 229221_AT, 227069_AT, 223723_AT, 212298_AT, 209555_S_AT, 212014_X_AT, 
               
               
                   
                 CC_ALL 
                 221731_X_AT, 203923_S_AT, 211066_X_AT, 210916_S_AT, 207674_AT, 219225_AT, 224480_S_AT, 
               
               
                   
                   
                 202828_S_AT, 214255_AT, 242871_AT, 238681_AT, 230360_AT, 236561_AT, 201925_S_AT, 
               
               
                   
                   
                 203729_AT, 217173_S_AT, 204489_S_AT, 228450_AT, 207610_S_AT, 205505_AT, 220307_AT, 
               
               
                   
                   
                 204620_S_AT, 211307_S_AT, 216080_S_AT, 232649_AT, 213577_AT, 203922_S_AT, 218686_S_AT, 
               
               
                   
                   
                 229937_X_AT, 214830_AT, 221815_AT, 227052_AT, 1552914_A_AT, 203104_AT, 213562_S_AT, 
               
               
                   
                   
                 212977_AT, 202756_S_AT, 228766_AT, 203508_AT, 210845_S_AT, 206033_S_AT, 201005_AT, 
               
               
                   
                   
                 201242_S_AT, 233220_AT, 207819_S_AT, 224674_AT, 214581_X_AT, 237252_AT, 160020_AT, 
               
               
                   
                   
                 214297_AT, 224967_AT, 63825_AT, 210233_AT, 228910_AT, 209949_AT, 214866_AT, 223501_AT, 
               
               
                   
                   
                 205534_AT, 34210_AT, 205099_S_AT, 205566_AT, 209994_S_AT, 1552690_A_AT, 1557905_S_AT, 
               
               
                   
                   
                 228754_AT, 209670_AT, 215836_S_AT, 217678_AT, 205717_X_AT, 217078_S_AT, 240076_AT, 
               
               
                   
                   
                 209047_AT, 209906_AT, 209218_AT, 221840_AT, 204619_S_AT, 215646_S_AT, 201626_AT, 
               
               
                   
                   
                 211030_S_AT, 205920_AT, 219926_AT, 208121_S_AT, 211676_S_AT, 235295_AT, 204257_AT, 
               
               
                   
                   
                 203233_AT, 224989_AT, 204105_S_AT, 204881_S_AT, 201125_S_AT, 217279_X_AT, 201627_S_AT, 
               
               
                   
                   
                 239791_AT, 201243_S_AT, 204912_AT, 23          638_AT, 211924_S_AT, 222877_AT, 203217_S_AT, 
               
               
                   
                   
                 209079_X_AT, 212062_AT, 22          083_AT, 204222_S_AT, 206488_S_AT, 206171_AT, 241954_AT, 
               
               
                   
                   
                 228640_AT, 205542_AT, 243894_AT, 204359_AT, 205891_AT, 204736_S_AT, 204490_S_AT, 
               
               
                   
                   
                 239519_AT, 219386_S_AT, 209835_X_AT, 208161_S_AT, 209921_AT, 218856_AT, 204715_AT, 
               
               
                   
                   
                 223502_S_AT, 225337_AT, 236345_AT, 220484_AT, 203387_S_AT, 223939_AT, 209146_AT, 
               
               
                   
                   
                 209392_AT, 228762_AT, 241773_AT, 224859_AT, 209993_AT, 201324_AT, 201625_S_AT, 
               
               
                   
                   
                 202539_S_AT, 204774_AT, 227180_AT, 241722_X_AT, 226218_AT, 204661_AT, 225809_AT, 
               
               
                   
                   
                 227107_AT, 20          401_AT, 211661_X_AT, 222062_AT, 202686_S_AT, 226931_AT, 219385_AT, 
               
               
                   
                   
                 223092_AT, 217552_X_AT, 202827_S_AT, 205419_AT, 87100_AT, 202071_AT, 210839_S_AT, 
               
               
                   
                   
                 224990_AT, 235299_AT, 225325_AT, 202068_S_AT, 220313_AT, 205718_AT, 203888_AT, 203935_AT, 
               
               
                   
                   
                 223798_AT, 228696_AT, 201995_AT, 1556583_S_AT, 229797_AT, 226302_AT, 241929_AT, 210173_AT, 
               
               
                   
                   
                 202067_S_AT, 219434_AT, 211571_S_AT, 205098_AT 
               
               
                   
                 GOTERM —   
                 21          _S_AT, 201464_X_AT, 2          540_X_AT, 2270          _AT, 2          43_S_AT, 21          0          _AT, 2122          _AT, 212014_X_AT, 214          3          _AT, 
               
               
                   
                 BP_ALL 
                 21          412_AT, 20          40_S_AT, 217997_AT, 2                    0          7_AT, 20          _X_AT, 201270_S_AT, 20          7          _AT, 2          _S_AT, 21          17_S_AT, 
               
               
                   
                   
                 235171_AT, 220307_AT, 201          _S_AT, 20114          _S_AT, 201          _X_AT, 230          _AT, 204          _AT, 22          15_AT, 155          14_A_AT, 
               
               
                   
                   
                 20          00_S_AT, 20          04_AT, 1555          32_S_AT, 20          _AT, 2221          _I_AT, 22          7          _AT, 2          5_S_AT, 214211_AT, 2145          1_X_AT, 
               
               
                   
                   
                 21          _          _AT,           5_AT, 20          _S_AT, 1405_I_AT, 201544_X_AT, 22          _AT, 2117          _X_AT, 22          01_AT, 20          _AT, 212          7_AT, 
               
               
                   
                   
                 22          0_AT, 20          _S_AT, 1557          5_S_AT, 2          02_S_AT, 20          5_AT, 222          70_S_AT, 2          20_S_AT, 21          _S_AT, 2          _S_AT, 
               
               
                   
                   
                 217          6_AT, 20          751_X_AT, 201150_S_AT, 2011          _S_AT, 155          2_AT, 217757_AT, 21          _AT, 1545734_X_AT, 22          _AT, 
               
               
                   
                   
                 20          _AT, 211          4_S_AT, 22          2_AT, 22          _AT, 21          0_S_AT, 2020          _AT, 23          _AT, 15          5752_AT, 20          _AT, 
               
               
                   
                   
                 204          _S_AT, 370          _AT, 2          5          _S_AT, 225557_AT, 237          1_AT, 37152_AT, 22          _AT, 2427          _AT,           _AT, 20          0          _S_AT, 
               
               
                   
                   
                 20          3_AT, 20          _S_AT, 21          42_S_AT, 22517          _AT, 22          6_AT, 200          78_AT, 225366_AT, 202          _AT, 2          3665_AT, 2047          6_S_AT, 
               
               
                   
                   
                 20          1_AT, 20          _X_AT, 23          519_AT, 20          _X_AT, 21          3          _AT, 22          11          _AT, 2121          0_AT, 20          71          _AT, 22          _S_AT, 
               
               
                   
                   
                 201          _S_AT, 212143_S_AT, 215          02_AT, 22          _AT, 2          _S_AT, 20          7_S_AT, 2276          1_S_AT, 202          _S_AT, 21          _AT, 
               
               
                   
                   
                 24          7          7_AT, 2273          0_AT, 210427_X_AT, 22          _AT, 21          _S_AT, 2007          _S_AT, 204401_AT,           0          _S_AT, 222062_AT, 
               
               
                   
                   
                 21          45_AT, 2272          _AT, 21          _AT, 210522_S_AT, 22          1          _AT, 217          2_X_AT, 2          525_X_AT, 2020          1_AT, 2          1          _AT, 20          0_AT, 
               
               
                   
                   
                 20          02_S_AT, 22          4_S_AT, 2424          _AT, 202241_AT, 2          1044_X_AT, 220          13_AT, 2          _AT, 210          _AT, 1          1_A_AT, 
               
               
                   
                   
                 20          5_AT, 21          1_AT, 215          _AT, 20          0          _AT, 210          5_X_AT, 22          221_AT, 210          6_AT, 20          5_S_AT, 23          15          _AT, 222041_S_AT, 
               
               
                   
                   
                 201473_AT,           _AT, 21          1          _S_AT, 2113          2_S_AT, 1          17_AT, 201471_S_AT, 2          57          _AT, 204472_S_AT, 20          2_AT, 
               
               
                   
                   
                 22          _S_AT, 2244          0_S_AT, 202          _S_AT, 21425          _AT, 2022          4_S_AT, 23          1_AT, 20          27_S_AT, 20          5_S_AT, 15          _AT, 
               
               
                   
                   
                 22          0_AT, 207          10_S_AT, 20          _AT, 212          _AT, 20          7          _AT, 155          1_A_AT, 225215_AT, 212477_AT, 20          0          _AT, 20          22_AT, 
               
               
                   
                   
                 220          25_AT, 210          5_S_AT, 24          6_AT, 201005_AT, 20          3_S_AT, 2          220_AT, 215292_S_AT, 1500          _AT, 212171_X_AT, 
               
               
                   
                   
                 2142          7_AT,           402_AT, 2          2          _AT, 2          4          7_AT, 224          _AT, 2          0          _AT, 202191_S_AT, 223          _AT, 202          _AT, 2          1          _X_AT, 
               
               
                   
                   
                 223          _AT, 20          _S_AT, 20          04_AT, 2027          _AT, 22          0          _AT, 220          1          _S_AT, 215          _AT, 23          1_AT, 200          72_AT, 212          _AT, 
               
               
                   
                   
                 22          7_AT, 22          7_S_AT, 21          4_AT, 212          0          _AT, 217279_X_AT, 221841_S_AT, 2          _AT, 2          34_S_AT, 23422          _S_AT, 
               
               
                   
                   
                 212          _AT, 21          2_AT, 24          _AT, 204172_AT, 25          _AT, 15          01_AT, 25          _AT, 200          1          _AT, 203          _AT, 204          0_S_AT, 
               
               
                   
                   
                 20          _S_AT, 2033          _S_AT, 2          30_AT, 20          157_AT, 225          7_AT, 20          015_AT, 232224_AT, 225          _AT, 24177          _AT, 2          2_AT, 
               
               
                   
                   
                 22          50_AT, 2010          2_AT, 20          3_AT, 212          _          _AT, 2          4442_X_AT, 21          _X_AT, 20          22_X_AT, 2          1722_X_AT, 22          708_AT, 
               
               
                   
                   
                 22          _S_AT, 227107_AT, 211          2_X_AT, 20          0_S_AT, 20          S_AT, 225207_AT, 20          21_S_AT,           0          _S_AT, 2230          2_AT, 
               
               
                   
                   
                 202          7_S_AT, 205419_AT,           7300_AT, 1562          7_AT, 210          _S_AT, 20          71_S_AT, 22          _AT, 22470          _AT, 220          5_S_AT, 
               
               
                   
                   
                 20          _AT, 15525          _A_AT, 20          _AT, 21          4_AT, 20          097_S_AT, 21237          _AT, 217          _X_AT, 227          7_AT, 15          5258_X_AT, 
               
               
                   
                   
                 241          _AT, 21          4          4_AT, 2          _AT, 22          _AT 
               
               
                   
                 GOTERM —   
                 39402_AT, 217757_AT, 216243_S_AT, 1405_I_AT, 204655_AT, 2091          9_AT, 201473_AT, 201044_X_AT, 
               
               
                   
                 BP_ALL 
                 201041_S_AT, 23          669_AT, 212657_S_AT, 205067_AT, 202284_S_AT, 1555759_A_AT, 207          19_S_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 201465_S_AT, 229221_AT, 212171_X_AT, 39402_AT, 1405_I_AT, 201566_X_AT, 
               
               
                   
                 BP_ALL 
                 212014_X_AT, 226218_AT, 223501_AT, 210916_S_AT, 218559_S_AT, 204923_AT, 1557905_S_AT, 
               
               
                   
                   
                 222067_AT, 205067_AT, 210512_S_AT, 202284_S_AT, 222670_S_AT, 217552_X_AT, 220066_AT, 
               
               
                   
                   
                 211527_X_AT, 201925_S_AT, 209906_AT, 204489_S_AT, 203665_AT, 205          91_AT, 203140_AT, 
               
               
                   
                   
                 204490_S_AT, 227752_AT, 213281_AT, 204655_AT, 210513_S_AT, 201565_S_AT, 209635_X_AT, 
               
               
                   
                   
                 221502_S_AT, 201466_S_AT, 1552914_A_AT, 203233_AT, 205312_AT, 1555759_A_AT, 224859_AT 
               
               
                   
                 GOTERM —   
                 39402_AT, 217757_AT, 216243_S_AT, 1405_I_AT, 204655_AT, 2091          9_AT, 201473_AT, 201044_X_AT, 
               
               
                   
                 BP_ALL 
                 201041_S_AT, 23          669_AT, 212657_S_AT, 205067_AT, 2022          4_S_AT, 1555759_A_AT, 207          19_S_AT 
               
               
                   
                 GOTERM —   
                 202540_S_AT, 2014          4_X_AT, 201465_S_AT, 21          02          _AT, 216248_S_AT, 39402_AT, 204622_X_AT, 
               
               
                   
                 BP_ALL 
                 205463_S_AT, 1405_I_AT, 211924_S_AT, 214          _AT, 223877_AT, 229830_AT, 205059_S_AT, 
               
               
                   
                   
                 211          61_X_AT, 235739_AT, 213763_AT, 2050          7_AT, 202          59_X_AT, 223092_AT, 221463_AT, 
               
               
                   
                   
                 209827_S_AT, 210839_S_AT, 1554992_AT, 20          06_AT, 20276          _AT, 2132          1_AT, 204655_AT, 
               
               
                   
                   
                 20          1          5_AT, 225116_AT, 201466_S_AT, 204025_AT, 225115_AT, 2204          4_AT, 2250          7_AT, 225797_AT, 
               
               
                   
                   
                 2253          _AT, 1555759_A_AT, 209          2_AT, 210815_S_AT, 2156          _AT, 202539_S_AT, 2050          _AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 237252_AT, 201463_S_AT, 39402_AT, 202241_AT, 2132          1_AT, 1405_I_AT, 204655_AT, 
               
               
                   
                 BP_ALL 
                 1552553_A_AT, 20          9_AT, 202708_S_AT, 201466_S_AT, 203          _AT, 221661_X_AT, 222062_AT, 
               
               
                   
                   
                 219          1          _X_AT, 203          7_S_AT, 227697_AT, 205495_S_AT, 205067_AT, 1555759_A_AT, 2200          6_AT, 
               
               
                   
                   
                 206438_S_AT 
               
               
                   
                 GOTERM —   
                 219028_AT, 216248_S_AT, 39402_AT, 205463_S_AT, 204622_X_AT, 1405_I_AT, 211924_S_AT, 
               
               
                   
                 BP_ALL 
                 214866_AT, 222877_AT, 229830_AT, 205099_S_AT, 211661_X_AT, 235739_AT, 213763_AT, 
               
               
                   
                   
                 205067_AT, 202859_X_AT, 223092_AT, 22          63_AT, 209827_S_AT, 210          39_S_AT, 20          06_AT, 
               
               
                   
                   
                 20          655_AT, 225116_AT, 204035_AT, 225115_AT, 2204          4_AT, 225097_AT, 229797_AT, 2253          _AT, 
               
               
                   
                   
                 1555759_A_AT, 20          392_AT, 210          45_S_AT, 205098_AT, 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 213891_S_AT, 201465_S_AT, 227069_AT, 21902          _AT, 21229          _AT, 210136_AT, 
               
               
                   
                 BP_ALL 
                 216834_AT, 201471_S_AT, 235739_AT, 202          2          _S_AT, 201067_AT, 236561_AT, 202          59_X_AT, 
               
               
                   
                   
                 2022          4_S_AT, 201170_S_AT, 203729_AT, 2284          0_AT, 21          017_S_AT, 2120          _AT, 201247_S_AT, 
               
               
                   
                   
                 201565_S_AT, 20          753_AT, 221          15_AT, 2552914_A_AT, 225215_AT, 22214          _S_AT, 205312_AT, 
               
               
                   
                   
                 201005_AT, 2100          5_S_AT, 160020_AT, 214211_AT, 212171_X_AT, 21624          _S_AT, 63          25_AT, 
               
               
                   
                   
                 39402_AT, 205          63_S_AT, 201566_X_AT, 22          964_AT, 22          501_AT, 22339          _AT, 22          30_AT, 212387_AT, 
               
               
                   
                   
                 205566_AT, 21          502_S_AT, 239          1          _X_AT, 222670_S_AT, 208476_S_AT, 200920_S_AT, 201150_S_AT, 
               
               
                   
                   
                 201148_S_AT, 217757_AT, 20276          _AT, 2132          1_AT, 210513_S_AT, 23          9_AT, 203233_AT, 
               
               
                   
                   
                 2          451_AT, 2123          6_AT, 225097_AT, 219257_S_AT, 212          3_AT, 2175          1_AT, 217279_X_AT, 37152_AT, 
               
               
                   
                   
                 221          41_S_AT, 224218_S_AT, 213763_AT, 1566901_AT, 220066_AT, 202          _AT, 203665_AT, 
               
               
                   
                   
                 204          _S_AT, 201149_S_AT, 239519_AT, 225116_AT, 22          502_S_AT, 201466_S_AT, 225337_AT, 
               
               
                   
                   
                 212143_S_AT, 204035_AT, 225368_AT, 202          _S_AT, 20          7_S_AT, 222652_S_AT, 224859_AT, 
               
               
                   
                   
                 205681_AT, 201012_AT, 204622_X_AT, 241722_X_AT, 218559_S_AT, 200748_S_AT, 203940_S_AT, 
               
               
                   
                   
                 200          21_S_AT, 219          45_AT, 21990          _AT, 210512_S_AT, 202          27_S_AT,           7100_AT, 211527_X_AT, 
               
               
                   
                   
                 20          140_AT, 220266_S_AT, 202241_AT, 2039          5_AT, 21025          _AT, 2276          7_AT, 2263          2_AT, 2233          _AT 
               
               
                   
                 GOTERM —   
                 160020_AT, 217173_S_AT, 20114          _S_AT, 203          5_AT, 39402_AT, 205463_S_AT, 201149_S_AT, 
               
               
                   
                 BP_ALL 
                 201147_S_AT, 20206          _S_AT, 201044_X_AT, 229          30_AT, 201042_S_AT, 201313_AT, 227697_AT, 
               
               
                   
                   
                 202          2          _S_AT, 205067_AT, 202827_S_AT, 236561_AT, 209047_AT, 217279_X_AT, 2020          7_S_AT, 
               
               
                   
                   
                 201150_S_AT 
               
               
                   
                 GOTERM —   
                 2          1464_X_AT, 214211_AT, 201465_S_AT, 225723_AT, 37152_AT, 210136_AT, 212171_X_AT, 
               
               
                   
                 BP_ALL 
                 39402_AT, 1405_I_AT, 241938_AT, 34210_AT, 20          61_AT, 205099_S_AT, 20074          _S_AT, 20          54          _S_AT, 
               
               
                   
                   
                 205067_AT, 210512_S_AT, 211527_X_AT, 200          7          _AT, 201925_S_AT, 1562          67_AT, 217173_S_AT, 
               
               
                   
                   
                 209906_AT, 216017_S_AT, 2036          5_AT, 2132          1_AT, 204655_AT, 210513_S_AT, 20206          _S_AT, 
               
               
                   
                   
                 20          466_S_AT, 239452_AT, 15565          3_A_AT, 212          03_AT, 1555759_A_AT, 241773_AT, 201005_AT, 
               
               
                   
                   
                 
                           
                 
               
               
                   
                 GOTERM —   
                 204912_AT, 213428_S_AT, 20          555_S_AT, 217757_AT, 205463_S_AT, 210233_AT, 226218_AT, 
               
               
                   
                 MF_ALL 
                 229830_AT, 212143_S_AT, 200935_AT, 203233_AT, 206          _S_AT, 228766_AT, 23          61_AT, 
               
               
                   
                   
                 241929_AT, 210095_S_AT 
               
               
                   
                 GOTERM —   
                 160020_AT, 20          665_AT, 201069_AT, 21624          _S_AT, 212171_X_AT, 204527_X_AT, 205463_S_AT, 
               
               
                   
                 BP_ALL 
                 210513_S_AT, 229          30_AT, 235739_AT, 219451_AT, 2276          7_AT, 15565          3_A_AT, 202          2          _S_AT, 
               
               
                   
                   
                 210512_S_AT, 2022          4_S_AT, 202          27_S_AT, 236562_AT, 211527_X_AT, 217179_X_AT, 201242_S_AT, 
               
               
                   
                   
                 200          7          _AT, 201243_S_AT 
               
               
                   
                 GOTERM —   
                 202540_S_AT, 20          55_S_AT, 205          52_S_AT, 2024          5_S_AT, 204972_AT, 2110          6_X_AT, 222          77_AT, 
               
               
                   
                 CC_ALL 
                 216971_          _AT, 20          079_X_AT, 219412_AT, 202434_S_AT, 2064          _S_AT, 24155          _AT, 20          _AT, 
               
               
                   
                   
                 201925_S_AT, 20          5_AT, 202436_S_AT, 20          91_AT, 2120          _AT, 216080_S_AT, 201500_X_AT, 
               
               
                   
                   
                 2          8161_S_AT, 211577_AT, 22          502_S_AT, 236345_AT, 212          6_X_AT, 21          562_S_AT, 22          7          _AT, 
               
               
                   
                   
                 20550          _AT, 2060          _S_AT, 20          9          _AT, 202          19_S_AT, 201324_AT, 202539_S_AT, 213503_X_AT, 
               
               
                   
                   
                 224          67_AT, 1405_I_AT, 21          427_X_AT, 223501_AT, 2040          _AT, 204          1_AT,           4210_AT, 20          _S_AT, 
               
               
                   
                   
                 2          95_S_AT, 215          6_S_AT, 205212_X_AT, 1562467_AT, 1554952_AT, 20921          _AT, 20          892_S_AT, 
               
               
                   
                   
                 204059_S_AT, 2045          5_AT, 2091          _AT, 202437_S_AT, 1554          00_S_AT, 2          _AT, 204257_AT, 
               
               
                   
                   
                 20131          _AT, 212089_AT, 2394          _AT, 20          81_S_AT, 155          5          3_A_AT, 202087_S_AT, 21925          _S_AT, 
               
               
                   
                   
                 1555799_A_AT, 226302_AT, 203411_S_AT, 141929_AT, 2136          _AT 
               
               
                   
                 GOTERM —   
                 202540_S_AT, 209555_S_AT, 202435_S_AT, 205552_S_AT, 204972_AT, 211066_X_AT, 222877_AT, 
               
               
                   
                 CC_ALL 
                 216971_S_AT, 209079_X_AT, 219412_AT, 202434_S_AT, 206488_S_AT, 241954_AT, 203939_AT, 
               
               
                   
                   
                 203665_AT, 202436_S_AT, 212099_AT, 216080_S_AT, 208161_S_AT, 213577_AT, 236345_AT 
               
               
                   
                   
                 212086_X_AT, 213562_S_AT, 228766_AT, 203508_AT, 206033_S_AT, 209993_AT, 201324_AT 
               
               
                   
                   
                 207819_S_AT, 202539_S_AT, 224967_AT, 34210_AT, 204661_AT, 209994_S_AT, 215836_S_AT 
               
               
                   
                   
                 205717_X_AT, 1562467_AT, 1554992_AT, 209218_AT, 209189_AT, 202437_S_AT, 1554600_S_AT 
               
               
                   
                   
                 238669_AT, 204257_AT, 212089_AT, 201313_AT, 239451_AT, 204881_S_AT, 1556583_A_AT, 
               
               
                   
                   
                 219257_S_AT, 203411_S_AT, 226302_AT, 241929_AT, 215688_AT 
               
               
                   
                 GOTERM —   
                 209906_AT, 39402_AT, 205463_S_AT, 1405_I_AT, 204655_AT, 211924_S_AT, 214866_AT, 222877_AT, 
               
               
                   
                 BP_ALL 
                 229830_AT, 205099_S_AT, 211661_X_AT, 204035_AT, 205067_AT, 202859_X_AT, 1555759_A_AT, 
               
               
                   
                   
                 209392_AT, 210845_S_AT, 221463_AT, 209827_S_AT, 210839_S_AT, 205098_AT 
               
               
                   
                 GOTERM —   
                 209906_AT, 39402_AT, 205463_S_AT, 1405_I_AT, 204655_AT, 211924_S_AT, 214866_AT, 222877_AT, 
               
               
                   
                 BP_ALL 
                 229830_AT, 205099_S_AT, 211661_X_AT, 204035_AT, 205067_AT, 202859_X_AT, 1555759_A_AT, 
               
               
                   
                   
                 209392_AT, 210845_S_AT, 221463_AT, 209827_S_AT, 210839_S_AT, 205098_AT 
               
               
                   
                 GOTERM —   
                 219028_AT, 39402_AT, 216834_AT, 223398_AT, 213763_AT, 239819_X_AT, 219645_AT, 205067_AT, 
               
               
                   
                 BP_ALL 
                 1566901_AT, 219908_AT, 220066_AT, 202388_AT, 203140_AT, 202241_AT, 225116_AT, 212143_S_AT, 
               
               
                   
                   
                 203935_AT, 225115_AT, 21025          _AT, 227697_AT, 225097_AT, 202988_S_AT, 225368_AT, 217591_AT, 
               
               
                   
                   
                 210095_S_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 229221_AT, 201465_S_AT, 39402_AT, 212014_X_AT, 201473_AT, 210916_S_AT, 
               
               
                   
                 BP_ALL 
                 1557905_S_AT, 205067_AT, 236561_AT, 202284_S_AT, 201150_S_AT, 201148_S_AT, 204489_S_AT, 
               
               
                   
                   
                 203665_AT, 204490_S_AT, 2132          1_AT, 201149_S_AT, 201147_S_AT, 209189_AT, 209835_X_AT, 
               
               
                   
                   
                 201466_S_AT, 201313_AT, 227697_AT, 209122_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 201465_S_AT, 219028_AT, 212298_AT, 219155_AT, 209555_S_AT, 216834_AT, 
               
               
                   
                 BP_ALL 
                 211352_S_AT, 219412_AT, 201471_S_AT, 235739_AT, 206472_S_AT, 208960_S_AT, 226389_S_AT, 
               
               
                   
                   
                 205067_AT, 236561_AT, 202859_X_AT, 20          891_AT, 207610_S_AT, 225171_AT, 212099_AT, 
               
               
                   
                   
                 220307_AT, 230266_AT, 1553982_A_AT, 207700_S_AT, 203104_AT, 225115_AT, 212977_AT, 
               
               
                   
                   
                 1555832_S_AT, 228766_AT, 204834_AT, 210845_S_AT, 230925_AT, 20          961_S_AT, 214581_X_AT, 
               
               
                   
                   
                 214297_AT, 216248_S_AT, 39402_AT, 210233_AT, 1405_I_AT, 214866_AT, 238909_AT, 223501_AT, 
               
               
                   
                   
                 2020          6_AT, 205039_S_AT, 239818_X_AT, 221463_AT, 209906_AT, 1554992_AT, 213281_AT, 
               
               
                   
                   
                 224606_AT, 211676_S_AT, 225738_AT, 216250_S_AT, 202073_AT, 203233_AT, 200872_AT, 
               
               
                   
                   
                 225097_AT, 219257_S_AT, 219994_AT, 227948_AT, 238649_AT, 211924_S_AT, 201041_S_AT, 
               
               
                   
                   
                 206488_S_AT, 213763_AT, 206171_AT, 225173_AT, 220066_AT, 200878_AT, 225166_AT, 
               
               
                   
                   
                 204736_S_AT, 205891_AT, 203665_AT, 239519_AT, 218856_AT, 225116_AT, 201466_S_AT, 
               
               
                   
                   
                 223502_S_AT, 204035_AT, 223939_AT, 225368_AT, 202988_S_AT, 241773_AT, 201012_AT, 
               
               
                   
                   
                 218501_AT, 204622_X_AT, 243797_AT, 22          708_AT, 226218_AT, 211661_X_AT, 202686_S_AT, 
               
               
                   
                   
                 20          93_S_AT, 225207_AT, 227265_AT, 2251          _AT, 205419_AT, 206571_S_AT, 22          368_AT, 
               
               
                   
                   
                 20          92_S_AT, 202241_AT, 204655_AT, 2091          9_AT, 203037_S_AT, 214054_AT, 220313_AT, 
               
               
                   
                   
                 201044_X_AT, 201595_AT, 227697_AT, 1555759_A_AT, 241929_AT, 219434_AT, 215688_AT, 
               
               
                   
                   
                 203320_AT, 205098_AT 
               
               
                   
                 GOTERM —   
                 212171_X_AT, 215026_AT, 39402_AT, 1405_I_AT, 223501_AT, 204923_AT, 222062_AT, 213763_AT, 
               
               
                   
                 BP_ALL 
                 205067_AT, 217552_X_AT, 202859_X_AT, 210512_S_AT, 208436_S_AT, 220066_AT, 209827_S_AT, 
               
               
                   
                   
                 211527_X_AT, 201925_S_AT, 209906_AT, 205891_AT, 204655_AT, 210513_S_AT, 225116_AT, 
               
               
                   
                   
                 223502_S_AT, 204035_AT, 225115_AT, 225097_AT, 225368_AT, 1555759_A_AT 
               
               
                   
                 GOTERM —   
                 160020_AT, 216248_S_AT, 39402_AT, 204622_X_AT, 205463_S_AT, 216243_S_AT, 1405_I_AT, 
               
               
                   
                 BP_ALL 
                 201473_AT, 204058_AT, 229630_AT, 201041_S_AT, 235739_AT, 212657_S_AT, 202828_S_AT, 
               
               
                   
                   
                 205067_AT, 202284_S_AT, 202827_S_AT, 236561_AT, 209047_AT, 1562467_AT, 201150_S_AT, 
               
               
                   
                   
                 217173_S_AT, 201148_S_AT, 203665_AT, 217757_AT, 204059_S_AT, 204655_AT, 201149_S_AT, 
               
               
                   
                   
                 2091          9_AT, 201147_S_AT, 202068_S_AT, 201044_X_AT, 238669_AT, 201313_AT, 227697_AT, 
               
               
                   
                   
                 1555759_A_AT, 217279_X_AT, 202067_S_AT, 207819_S_AT 
               
               
                   
                 GOTERM —   
                 203665_AT, 205891_AT, 203940_S_AT, 39402_AT, 200921_S_AT, 212099_AT, 219257_S_AT, 
               
               
                   
                 BP_ALL 
                 205067_AT, 208937_S_AT, 200920_S_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 201465_S_AT, 229221_AT, 216248_S_AT, 39402_AT, 204522_X_AT, 205463_S_AT, 
               
               
                   
                 BP_ALL 
                 221841_S_AT, 212014_X_AT, 210916_S_AT, 229830_AT, 201041_S_AT, 235739_AT, 1557905_S_AT, 
               
               
                   
                   
                 202686_S_AT, 205067_AT, 202284_S_AT, 201150_S_AT, 201148_S_AT, 2044          9_S_AT, 203655_AT, 
               
               
                   
                   
                 205891_AT, 204490_S_AT, 220266_S_AT, 217757_AT, 213281_AT, 201149_S_AT, 209189_AT, 
               
               
                   
                   
                 201147_S_AT, 209835_X_AT, 201044_X_AT, 201466_S_AT, 227697_AT, 1556583_A_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 213891_S_AT, 229221_AT, 201465_S_AT, 219028_AT, 212298_AT, 209555_S_AT, 
               
               
                   
                 BP_ALL 
                 212014_X_AT, 201473_AT, 211352_S_AT, 210916_S_AT, 201471_S_AT, 235739_AT, 208960_S_AT, 
               
               
                   
                   
                 205067_AT, 217997_AT, 236561_AT, 202284_S_AT, 1569149_AT, 204489_S_AT, 201147_S_AT, 
               
               
                   
                   
                 201565_S_AT, 203753_AT, 207700_S_AT, 1552914_A_AT, 225115_AT, 1555832_S_AT, 228766_AT, 
               
               
                   
                   
                 222146_S_AT, 205312_AT, 243536_AT, 208961_S_AT, 210095_S_AT, 212171_X_AT, 216248_S_AT, 
               
               
                   
                   
                 39402_AT, 205463_S_AT, 1405_I_AT, 235457_AT, 201566_X_AT, 223501_AT, 2296830_AT, 2123          7_AT, 
               
               
                   
                   
                 2020          6_AT, 1557905_S_AT, 222670_S_AT, 200920_S_AT, 201150_S_AT, 203751_X_AT, 217996_AT, 
               
               
                   
                   
                 20114          _S_AT, 1554992_AT, 213281_AT, 224606_AT, 210513_S_AT, 1565754_X_AT, 225842_AT, 
               
               
                   
                   
                 235295_AT, 1565752_AT, 203233_AT, 204105_S_AT, 212386_AT, 225097_AT, 203752_S_AT, 
               
               
                   
                   
                 219257_S_AT, 225557_AT, 37152_AT, 227948_AT, 221841_S_AT, 242794_AT, 21294          _AT, 204923_AT, 
               
               
                   
                   
                 201041_S_AT, 206488_S_AT, 213763_AT, 1554453_AT, 1566901_AT, 220066_AT, 200878_AT, 
               
               
                   
                   
                 205891_AT, 203665_AT, 204490_S_AT, 201149_S_AT, 239519_AT, 209835_X_AT, 225116_AT, 
               
               
                   
                   
                 204715_AT, 206157_AT, 201466_S_AT, 223502_S_AT, 212143_S_AT, 204035_AT, 215602_AT, 
               
               
                   
                   
                 212124_AT, 225368_AT, 241773_AT, 224859_AT, 218501_AT, 243797_AT, 204622_X_AT, 227240_AT, 
               
               
                   
                   
                 226218_AT, 218559_S_AT, 227107_AT, 204401_AT, 200921_S_AT, 203548_S_AT, 210512_S_AT, 
               
               
                   
                   
                 211527_X_AT, 244414_AT, 203140_AT, 242405_AT, 220266_S_AT, 204655_AT, 1552553_A_AT, 
               
               
                   
                   
                 209189_AT, 201044_X_AT, 203935_AT, 227697_AT, 1555759_A_AT, 241929_AT, 21563          _AT, 
               
               
                   
                   
                 223394_AT 
               
               
                   
                 GOTERM —   
                 202540_S_AT, 209555_S_AT, 202435_S_AT, 205552_S_AT, 204972_AT, 211066_X_AT, 222877_AT, 
               
               
                   
                 CC_ALL 
                 209079_X_AT, 219412_AT, 202434_S_AT, 206488_S_AT, 241954_AT, 203939_AT, 203665_AT, 
               
               
                   
                   
                 202436_S_AT, 212099_AT, 216080_S_AT, 208161_S_AT, 213577_AT, 236345_AT, 213562_S_AT, 
               
               
                   
                   
                 228766_AT, 203508_AT, 206033_S_AT, 201324_AT, 207819_S_AT, 209993_AT, 202539_S_AT, 
               
               
                   
                   
                 224967_AT, 34210_AT, 204661_AT, 209994_S_AT, 215836_S_AT, 205717_X_AT, 1562467_AT, 
               
               
                   
                   
                 1554992_AT, 209218_AT, 209189_AT, 202437_S_AT, 238669_AT, 204257_AT, 201313_AT, 239451_AT, 
               
               
                   
                   
                 204881_S_AT, 1556583_A_AT, 219257_S_AT, 226302_AT, 241929_AT, 215688_AT 
               
               
                   
                 GOTERM —   
                 202540_S_AT, 223723_AT, 227069_AT, 212298_AT, 212014_X_AT, 221731_X_AT, 203923_S_AT, 219412_AT, 
               
               
                   
                 CC_ALL 
                 207674_AT, 2186          1_AT, 209803_S_AT, 226545_AT, 203729_AT, 217173_S_AT, 2044          9_S_AT, 205505_AT, 
               
               
                   
                   
                 204620_S_AT, 220307_AT, 223303_AT, 211307_S_AT, 216080_S_AT, 232649_AT, 203922_S_AT, 21          6          6_S_AT, 
               
               
                   
                   
                 221          15_AT, 1552          14_A_AT, 203104_AT, 2135          2_S_AT, 202756_S_AT, 22          766_AT, 224674_AT, 2145          1_X_AT, 
               
               
                   
                   
                 224967_AT, 63825_AT, 211719_X_AT, 209949_AT, 223501_AT, 205099_S_AT, 1557          05_S_AT, 215836_S_AT, 
               
               
                   
                   
                 238542_AT, 209670_AT, 209047_AT, 240076_AT, 217078_S_AT, 221          40_AT, 201626_AT, 219926_AT, 211676_S_AT, 
               
               
                   
                   
                 238669_AT, 204257_AT, 203233_AT, 204105_S_AT, 224989_AT, 239761_AT, 201263_S_AT, 204912_AT, 23861          _AT, 
               
               
                   
                   
                 222877_AT, 209079_X_AT, 212062_AT, 22          0          3_AT, 202434_S_AT, 204222_S_AT, 2064          _S_AT, 22          640_AT, 
               
               
                   
                   
                 205542_AT, 203665_AT, 204736_S_AT, 205          1_AT, 204359_AT, 202748_AT, 239519_AT, 20          35_X_AT, 
               
               
                   
                   
                 20          262_S_AT, 218          56_AT, 204715_AT, 223502_S_AT, 236345_AT, 223939_AT, 203          7_S_AT, 204774_AT, 
               
               
                   
                   
                 20253          _S_AT, 22621          _AT, 204661_AT, 225          09_AT, 204401_AT, 202          _S_AT, 222062_AT, 2251          _AT, 
               
               
                   
                   
                 217552_X_AT, 202071_AT, 2249          0_AT, 225325_AT, 220313_AT, 20571          _AT, 203          35_AT, 1556583_A_AT, 
               
               
                   
                   
                 201995_AT, 229797_AT, 226302_AT, 210173_AT, 2050          8_AT, 210495_X_AT, 229221_AT, 210136_AT, 209555_S_AT, 
               
               
                   
                   
                 202435_S_AT, 211066_X_AT, 210916_S_AT, 2244          0_S_AT, 21          225_AT, 20282          _S_AT, 242          71_AT, 214255_AT, 
               
               
                   
                   
                 236561_AT, 230360_AT, 201925_S_AT, 22          0_AT, 207610_S_AT, 212099_AT, 213577_AT, 229          37_X_AT, 
               
               
                   
                   
                 214          30_AT, 227052_AT, 212977_AT, 20350          _AT, 2          0925_AT, 210          5_S_AT, 2010          5_AT, 206033_S_AT, 
               
               
                   
                   
                 201242_S_AT, 233220_AT, 207819_S_AT, 242907_AT, 209122_AT, 160020_AT, 237252_AT, 214297_AT, 210233_AT, 
               
               
                   
                   
                 22          910_AT, 214          66_AT, 205534_AT, 34210_AT, 205566_AT, 209994_S_AT, 1552690_A_AT, 22          754_AT, 217678_AT, 
               
               
                   
                   
                 205717_X_AT, 2385          1_AT, 209906_AT, 209218_AT, 215646_S_AT, 204619_S_AT, 205520_AT, 213030_S_AT, 
               
               
                   
                   
                 20          121_S_AT, 235295_AT, 20          1_S_AT, 239451_AT, 219994_AT, 217279_X_AT, 201125_S_AT, 202627_S_AT, 
               
               
                   
                   
                 231924_S_AT, 203217_S_AT, 206171_AT, 241554_AT, 203          3          _AT, 2          54_AT, 202436_S_AT, 204490_S_AT, 
               
               
                   
                   
                 219386_S_AT, 20          921_AT, 225337_AT, 2204          4_AT, 209145_AT, 241773_AT, 22          762_AT, 20          392_AT, 224859_AT, 
               
               
                   
                   
                 201625_S_AT, 201324_AT, 209993_AT, 201012_AT, 212464_S_AT, 216442_X_AT, 227180_AT, 241722_X_AT, 
               
               
                   
                   
                 22          708_AT, 214724_AT, 227107_AT, 211661_X_AT, 226          31_AT, 20354          _S_AT, 2193          5_AT, 202827_S_AT, 
               
               
                   
                   
                 2230          2_AT,           7200_AT, 205419_AT, 210          39_S_AT, 235299_AT, 219332_AT, 202437_S_AT, 20206          _S_AT, 20          _AT, 
               
               
                   
                   
                 223798_AT, 22          696_AT, 241929_AT, 202067_S_AT, 219434_AT, 211571_S_AT 
               
               
                   
                 GOTERM —   
                 160020_AT, 203665_AT, 201069_AT, 216248_S_AT, 212171_X_AT, 204622_X_AT, 205463_S_AT, 
               
               
                   
                 BP_ALL 
                 220513_S_AT, 229          30_AT, 235739_AT, 23          451_AT, 15565          3_A_AT, 227697_AT, 202          2          _S_AT, 
               
               
                   
                   
                 202827_S_AT, 210512_S_AT, 236561_AT, 217279_X_AT, 211527_X_AT, 201242_S_AT, 2          78_AT, 
               
               
                   
                   
                 201243_S_AT 
               
               
                   
                 GOTERM —   
                 20          06_AT, 20          5_AT, 20          140_AT, 205          1_AT, 39402_AT, 217757_AT, 22621          _AT, 223501_AT, 
               
               
                   
                 BP_ALL 
                 223502_S_AT, 1552          14_A_AT, 204923_AT, 203233_AT, 222062_AT, 205067_AT, 217552_X_AT, 
               
               
                   
                   
                 220066_AT, 224          59_AT, 201925_S_AT 
               
               
                   
                 GOTERM —   
                 219028_AT, 39402_AT, 216          34_AT, 22          8_AT, 213          63_AT, 239          1          _X_AT, 219          45_AT, 2050          7_AT, 
               
               
                   
                 BP_ALL 
                 15          01_AT, 21          0          _AT, 220066_AT, 202          _AT, 20          140_AT, 202241_AT, 22511          _AT, 21214          _S_AT, 
               
               
                   
                   
                 2039          5_AT, 225115_AT, 21025          _AT, 227697_AT, 2250          7_AT, 2029          _S_AT, 22536          _AT, 2175          1_AT, 
               
               
                   
                   
                 2100          5_S_AT 
               
               
                   
                 GOTERM —   
                 203140_AT, 222062_AT, 227          97_AT, 39402_AT, 217757_AT, 20350          _AT, 205067_AT, 22621          _AT, 
               
               
                   
                 BP_ALL 
                 224          _AT, 20          9_AT, 233220_AT, 1552914_A_AT 
               
               
                   
                 GOTERM —   
                 20114          _S_AT, 204620_S_AT, 20114          _S_AT, 221924_S_AT, 201147_S_AT, 215646_S_AT, 204619_S_AT, 
               
               
                   
                 BP_ALL 
                 221731_X_AT, 214          6_AT, 20          6_S_AT, 227          7_AT, 2022          4_S_AT, 236561_AT, 210          45_S_AT, 
               
               
                   
                   
                 211571_S_AT, 201150_S_AT, 20          5_S_AT 
               
               
                   
                 GOTERM —   
                 160020_AT, 39402_AT, 205          3_S_AT, 2162          3_S_AT, 1405_I_AT, 20147          _AT, 204          5          _AT, 22          30_AT, 
               
               
                   
                 BP_ALL 
                 201041_S_AT, 212657_S_AT, 202          2          _S_AT, 205067_AT, 2022          4_S_AT, 202          27_S_AT, 236561_AT, 
               
               
                   
                   
                 209047_AT, 201150_S_AT, 217173_S_AT, 2011          _S_AT, 203665_AT, 217757_AT, 204059_S_AT, 
               
               
                   
                   
                 204          55_AT, 2011          _S_AT, 2091          _AT, 201147_S_AT, 20206          _S_AT, 2010          4_X_AT, 23          _AT, 
               
               
                   
                   
                 201313_AT, 227          7_AT, 155575          _A_AT, 217279_X_AT, 202067_S_AT, 207          19_S_AT 
               
               
                   
                 GOTERM —   
                 214211_AT, 201464_X_AT, 223723_AT, 2014          5_S_AT, 37152_AT, 2101          6_AT,           402_AT, 1          5_I_AT, 
               
               
                   
                 BP_ALL 
                 242938_AT, 20          661_AT, 34220_AT, 2050          9_S_AT, 2007          _S_AT, 205067_AT, 201925_S_AT, 1562467_AT, 
               
               
                   
                   
                 20          06_AT, 216017_S_AT, 203          5_AT, 213281_AT, 204655_AT, 201          _S_AT, 239451_AT, 
               
               
                   
                   
                 155          3_A_AT, 212          _AT, 155575          _A_AT, 241773_AT, 201005_AT, 2050          _AT 
               
               
                   
                 GOTERM —   
                 210          5_X_AT, 22          221_AT, 37152_AT, 21229          _AT, 2          555_S_AT, 212014_S_AT, 221731_X_AT, 
               
               
                   
                 BP_ALL 
                 2110          _X_AT, 222877_AT, 210          _S_AT, 209079_X_AT, 2064          _S_AT, 228640_AT, 2044          _S_AT, 
               
               
                   
                   
                 21342          _S_AT, 20          35          _AT, 2044          0_S_AT, 204620_S_AT, 2120          _AT, 22          _AT, 23          519_AT, 
               
               
                   
                   
                 20          15_X_AT, 207571_X_AT, 22          7          _AT, 22          73_AT, 206013_S_AT, 201005_AT, 212464_S_AT, 
               
               
                   
                   
                 216442_X_AT, 1405_I_AT, 21171          _X_AT, 205534_AT, 2050          9_S_AT, 15579          5_S_AT, 215          36_S_AT, 
               
               
                   
                   
                 205717_X_AT, 2251          _AT, 21707          _S_AT, 204655_AT, 215646_S_AT, 20          619_S_AT, 2107          5_S_AT, 
               
               
                   
                   
                 20          037_S_AT, 216250_S_AT, 20          71          _AT, 2          41          5_S_AT, 155575          _A_AT, 241929_A_AT, 201125_S_AT, 
               
               
                   
                   
                 211571_S_AT, 2050          _AT 
               
               
                   
                 GOTERM —   
                 2104          5_X_AT, 229211_AT, 37152_AT, 2122          _AT, 20          555_S_AT, 212014_X_AT, 221731_X_AT, 
               
               
                   
                 BP_ALL 
                 212066_X_AT, 222          77_AT, 210916_S_AT, 2          9079_X_AT, 206          _S_AT, 22          640_AT, 2044          _S_AT; 
               
               
                   
                   
                 21342          _S_AT, 20435          _AT, 20          490_S_AT, 204620_S_AT, 2120          _AT, 223          03_AT, 239519_AT, 
               
               
                   
                   
                 20          35_X_AT, 207571_X_AT, 228766_AT, 22887          _AT, 206013_S_AT, 201005_AT, 212464_S_AT, 
               
               
                   
                   
                 216442_X_AT, 1405_I_AT, 211719_X_AT, 205534_AT, 2050          9_S_AT, 1557          05_S_AT, 215          36_S_AT, 
               
               
                   
                   
                 205717_X_AT, 22          1          _AT, 217070_S_AT, 2          4          55_AT, 2156          _S_AT, 204          19_S_AT, 210785_S_AT, 
               
               
                   
                   
                 203037_S_AT, 216250_S_AT, 20571          _AT, 204105_S_AT, 155575          _A_AT, 24192          _AT, 201125_S_AT, 
               
               
                   
                   
                 211571_S_AT, 2050          _AT 
               
               
                   
                 GOTERM —   
                 214211_AT, 201          64_X_AT, 22          723_AT, 2014          _S_AT, 37152_AT, 210          6_AT, 39402_AT, 1405_I_AT, 
               
               
                   
                 BP_ALL 
                 241          _AT, 204661_AT, 34210_AT, 2050          _S_AT, 2007          _S_AT, 205067_AT, 201          25_S_AT, 1562          67_AT, 
               
               
                   
                   
                 20          906_AT, 21          017_S_AT, 2132          1_AT, 2          655_AT, 20146          _S_AT, 23          452_AT, 155          _A_AT, 
               
               
                   
                   
                 212          _AT, 155575          _A_AT, 2417          _AT, 20100          _AT, 2          0          _AT 
               
               
                   
                 GOTERM —   
                 214231_AT, 201464_X_AT, 223723_AT, 201465_S_AT, 37152_AT, 210136_AT, 39402_AT, 1405_I_AT 
               
               
                   
                 BP_ALL 
                 241938_AT, 204661_AT, 34210_AT, 205099_S_AT, 200748_S_AT, 205067_AT, 201925_S_AT, 1562467_AT 
               
               
                   
                   
                 209906_AT, 216017_S_AT, 213281_AT, 204655_AT, 201466_S_AT, 239451_AT, 1556583_A_AT 
               
               
                   
                   
                 212803_AT, 1555759_A_AT, 241773_AT, 201005_AT, 205098_AT 
               
               
                   
                 GOTERM —   
                 209906_AT, 205891_AT, 203140_AT, 212171_X_AT, 39402_AT, 210513_S_AT, 226218_AT, 223501_AT 
               
               
                   
                 BP_ALL 
                 223502_S_AT, 1552914_A_AT, 204923_AT, 203233_AT, 222062_AT, 205067_AT, 210512_S_AT 
               
               
                   
                   
                 202284_S_AT, 217552_X_AT, 220066_AT, 211527_X_AT, 224859_AT, 201925_S_AT 
               
               
                   
                 GOTERM —   
                 203665_AT, 205891_AT, 203140_AT, 222062_AT, 39402_AT, 205067_AT, 220066_AT, 226218_AT 
               
               
                   
                 BP_ALL 
                 204923_AT 
               
               
                   
                 GOTERM —   
                 237252_AT, 201464_X_AT, 201465_S_AT, 39402_AT, 202241_AT, 213281_AT, 1405_I_AT, 204655_AT 
               
               
                   
                 BP_ALL 
                 209189_AT, 201466_S_AT, 203888_AT, 211661_X_AT, 239818_X_AT, 203887_S_AT, 227697_AT 
               
               
                   
                   
                 205067_AT, 1555759_A_AT, 220066_AT 
               
               
                   
                 KEGG —   
                 229221_AT, 204489_S_AT, 204490_S_AT, 209555_S_AT, 39402_AT, 212014_X_AT, 209835_X_AT 
               
               
                   
                 PATHWAY 
                 226218_AT, 210916_S_AT, 203104_AT, 1557905_S_AT, 203233_AT, 206488_S_AT, 228766_AT, 205067_AT 
               
               
                   
                   
                 217552_X_AT, 241929_AT, 201005_AT, 201925_S_AT 
               
               
                   
                 GOTERM —   
                 203140_AT, 203233_AT, 222062_AT, 39402_AT, 205067_AT, 220066_AT, 226218_AT, 223501_AT 
               
               
                   
                 BP_ALL 
                 223502_S_AT, 204923_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 237252_AT, 201465_S_AT, 37152_AT, 219028_AT, 39402_AT, 1405_I_AT, 201473_AT 
               
               
                   
                 BP_ALL 
                 202708_S_AT, 202086_AT, 211661_X_AT, 213763_AT, 203882_AT, 222062_AT, 239818_X_AT, 205067_AT, 
               
               
                   
                   
                 236561_AT, 208436_S_AT, 220066_AT, 209827_S_AT, 204475_AT, 217173_S_AT, 214453_S_AT, 
               
               
                   
                   
                 213281_AT, 202241_AT, 204655_AT, 1552553_A_AT, 209189_AT, 202068_S_AT, 211676_S_AT, 
               
               
                   
                   
                 225116_AT, 229937_X_AT, 201466_S_AT, 206157_AT, 203888_AT, 225115_AT, 212977_AT, 203887_S_AT, 
               
               
                   
                   
                 227697_AT, 225097_AT, 205495_S_AT, 225368_AT, 1555759_A_AT, 202067_S_AT, 208438_S_AT, 
               
               
                   
                   
                 213293_S_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 202540_S_AT, 201465_S_AT, 37152_AT, 210136_AT, 202435_S_AT, 241938_AT, 212948_AT, 
               
               
                   
                 BP_ALL 
                 228083_AT, 202434_S_AT, 205067_AT, 200878_AT, 217173_S_AT, 216017_S_AT, 205891_AT, 203665_AT, 
               
               
                   
                   
                 202436_S_AT, 201149_S_AT, 201147_S_AT, 201466_S_AT, 220484_AT, 201005_AT, 233220_AT, 
               
               
                   
                   
                 202539_S_AT, 212171_X_AT, 39402_AT, 204401_AT, 1552690_A_AT, 206835_AT, 204684_AT, 235944_AT, 
               
               
                   
                   
                 210512_S_AT, 209047_AT, 211527_X_AT, 201150_S_AT, 1562467_AT, 201148_S_AT, 1554992_AT, 
               
               
                   
                   
                 209906_AT, 213281_AT, 202437_S_AT, 209189_AT, 210513_S_AT, 2020268_S_AT, 212372_AT, 238669_AT, 
               
               
                   
                   
                 1556583_A_AT, 229797_AT, 212803_AT, 202067_S_AT, 215688_AT 
               
               
                   
                 GOTERM —   
                 213          1_S_AT, 201464_X_AT, 2025          0_S_AT, 2270          _AT, 2014          5_S_AT, 219028_AT, 21229          _AT, 212014_X_AT, 
               
               
                   
                 BP_ALL 
                 216          34_AT, 219412_AT, 20          60_S_AT, 217          93_AT, 205067_AT, 202          59_X_AT, 202170_S_AT, 20          729_AT, 2044          _S_AT, 
               
               
                   
                   
                 116017_S_AT, 225171_AT, 220          07_AT, 201565_S_AT, 201147_S_AT, 230266_AT, 204          3_AT, 221          15_AT, 207700_S_AT, 
               
               
                   
                   
                 1552914_A_AT, 20          104_AT, 1555          2_S_AT, 204          34_AT, 2221          _S_AT, 22          76          _AT, 210095_S_AT, 214211_AT, 
               
               
                   
                   
                 2145          1_X_AT, 21624          _S_AT, 63          25_AT, 203          63_S_AT, 1405_I_AT, 201566_X_AT, 22          964_AT, 211719_X_AT, 223501_AT, 
               
               
                   
                   
                 2020          _AT, 212          7_AT, 220          0_AT, 2000          9_S_AT, 1557          05_S_AT, 21          502_S_AT, 222670_S_AT, 200920_S_AT, 
               
               
                   
                   
                 2191          3_S_AT, 20          _S_AT, 217          6_AT, 203751_X_AT, 201150_S_AT, 2011          _S_AT, 155          2_AT, 217757_AT, 
               
               
                   
                   
                 22          3_AT, 1565754_X_AT, 20          606_AT, 213676_S_AT, 225          2_AT, 22573          _AT, 216250_S_AT, 202073_AT, 23          6          _AT, 
               
               
                   
                   
                 1565752_AT, 203233_AT, 204105_S_AT, 3702          _AT, 20          752_S_AT, 225557_AT, 2175          1_AT, 37152_AT, 227          _AT, 
               
               
                   
                   
                 24279          _AT, 2419          _AT, 201041_S_AT, 204          23_AT, 20          8_S_AT, 2119          2_S_AT, 225173_AT, 220066_AT, 20067          _AT, 
               
               
                   
                   
                 2251          _AT, 202          _AT, 203          _AT, 20473          _S_AT, 205          1_AT, 21          529_AT, 209          5_X_AT, 21          5          _AT, 225116_AT, 
               
               
                   
                   
                 2121          0_AT, 204715_AT, 223502_S_AT, 201466_S_AT, 212143_S_AT, 215          02_AT, 223          _AT, 202          _S_AT, 
               
               
                   
                   
                 20          17_S_AT, 222651_S_AT, 202          _S_AT, 21          502_AT, 2437          7_AT, 227340_AT, 22          213_AT, 20074          _S_AT, 204401_AT, 
               
               
                   
                   
                 202          _S_AT, 222062_AT, 21          45_AT, 2272          5_AT, 21          0          _AT, 210512_S_AT, 2251          _AT, 211527_X_AT, 202072_AT, 
               
               
                   
                   
                 244414_AT, 203140_AT, 20          2_S_AT, 2202          _S_AT, 242          0          _AT, 202241_AT, 201044_X_AT, 220          13_AT, 20          _AT, 
               
               
                   
                   
                 220          _AT, 201          _AT, 226302_AT, 215          _AT, 2050          _AT, 210          5_X_AT, 229221_AT, 2101          6_AT, 20          _S_AT, 
               
               
                   
                   
                 219155_AT, 221011_S_AT, 201473_AT, 20247          _AT, 210          36_S_AT, 211352_S_AT, 1555          27_AT, 201471_S_AT, 23573          _AT, 
               
               
                   
                   
                 206472_S_AT, 203          7_AT, 22          9_S_AT, 2244          0_S_AT, 202          2          _S_AT, 214255_AT, 2022          4_S_AT, 236561_AT, 
               
               
                   
                   
                 209          27_S_AT, 156          149_AT, 22          490_AT, 207          10_S_AT, 20          1_AT, 2120          _AT, 20          753_AT, 155          _A_AT, 225125_AT, 
               
               
                   
                   
                 212          77_AT, 20550          _AT, 205312_AT, 230          25_AT, 210          45_S_AT, 24          556_AT, 201005_AT, 20          61_S_AT, 21529          _S_AT, 
               
               
                   
                   
                 160020_AT, 212171_X_AT, 214297_AT, 39402_AT, 2102          _AT, 235457_AT, 214          66_AT, 23          0          _AT, 202191_S_AT, 
               
               
                   
                   
                 2233          _AT, 20          6_AT, 23          1          _X_AT, 221          63_AT, 20          436_S_AT, 2027          06_AT, 20          _AT, 224606_AT, 210511_S_AT, 
               
               
                   
                   
                 2352          5_AT, 23          451_AT, 200          72_AT, 2123          6_AT, 2250          7_AT, 219257_S_AT, 21          4_AT, 212          0          _AT, 217279_X_AT, 
               
               
                   
                   
                 221841_S_AT, 23          49_AT, 211924_S_AT, 22421          _S_AT, 2129          _AT, 213763_AT, 206171_AT, 1564433_AT, 156          01_AT, 
               
               
                   
                   
                 1560226_AT, 202014_AT, 2044          0_S_AT, 2049          _S_AT, 20114          _S_AT, 23          570_AT, 20          157_AT, 225          7_AT, 204235_AT, 
               
               
                   
                   
                 212124_AT, 22536          _AT, 241773_AT, 20          292_AT, 224          59_AT, 201012_AT, 205681_AT, 212464_S_AT, 216442_X_AT, 
               
               
                   
                   
                 204622_X_AT, 241722_X_AT, 22          70          _AT, 21          559_S_AT, 227107_AT, 211          1_X_AT, 20          40_S_AT, 20          3_S_AT, 
               
               
                   
                   
                 225207_AT, 200          21_S_AT, 203548_S_AT, 202          27_S_AT, 20541          _AT,           7100_AT, 1562467_AT, 210          _S_AT, 
               
               
                   
                   
                 206571_S_AT, 22          36          _AT, 224701_AT, 220          35_S_AT, 204          _AT, 1552553_A_AT, 20          1          _AT, 214054_AT, 203037_S_AT, 
               
               
                   
                   
                 212372_AT, 2276          7_AT, 155575          _A_AT, 241          29_AT, 21943          _AT, 20          20_AT, 22          _AT 
               
               
                   
                 GOTERM —   
                 203140_AT, 203233_AT, 222062_AT, 39402_AT, 205067_AT, 220066_AT, 226218_AT, 223501_AT, 
               
               
                   
                 BP_ALL 
                 223502_S_AT, 204923_AT 
               
               
                   
                 GOTERM —   
                 223723_AT, 212099_AT, 228708_AT, 211924_S_AT, 214866_AT, 34210_AT, 204661_AT, 202756_S_AT, 
               
               
                   
                 CC_ALL 
                 203548_S_AT, 238542_AT, 226545_AT, 210          45_S_AT, 203939_AT, 201925_S_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 214211_AT, 201465_S_AT, 223723_AT, 37152_AT, 212171_X_AT, 210136_AT, 
               
               
                   
                 BP_ALL 
                 39402_AT, 241722_X_AT, 1405_I_AT, 201566_X_AT, 22621          _AT, 223501_AT, 241938_AT, 204661_AT, 
               
               
                   
                   
                 34210_AT, 20074          _S_AT, 205099_S_AT, 204401_AT, 2035          8_S_AT, 205067_AT, 210512_S_AT, 
               
               
                   
                   
                 211527_X_AT, 20087          _AT, 201925_S_AT, 1562467_AT, 217173_S_AT, 209906_AT, 216017_S_AT, 
               
               
                   
                   
                 203665_AT, 203140_AT, 2132          1_AT, 204655_AT, 210513_S_AT, 201565_S_AT, 202068_S_AT, 
               
               
                   
                   
                 223502_S_AT, 201466_S_AT, 239451_AT, 15565          3_A_AT, 212803_AT, 1555759_A_AT, 241773_AT, 
               
               
                   
                   
                 201005_AT, 202067_S_AT, 20509          _AT 
               
               
                   
                 GOTERM —   
                 206488_S_AT, 37152_AT, 209555_S_AT, 22          754_AT, 22          766_AT, 226302_AT, 211030_S_AT 
               
               
                   
                 BP_ALL 
                 205920_AT, 241929_AT, 208161_S_AT, 201012_AT, 209122_AT 
               
               
                   
                 GOTERM —   
                 212171_X_AT, 63825_AT, 205463_S_AT, 229          30_AT, 205566_AT, 203940_S_AT, 239          18_X_AT, 
               
               
                   
                 BP_ALL 
                 202859_X_AT, 210512_S_AT, 87100_AT, 209827_S_AT, 211527_X_AT, 210          39_S_AT, 228490_AT, 
               
               
                   
                   
                 203665_AT, 202241_AT, 210513_S_AT, 212190_AT, 221815_AT, 225337_AT, 212143_S_AT, 
               
               
                   
                   
                 204035_AT, 219257_S_AT, 209392_AT, 210095_S_AT 
               
               
                   
                 GOTERM —   
                 213          91_S_AT, 201464_X_AT, 227069_AT, 201465_S_AT, 37152_AT, 21902          _AT, 221          41_S_AT, 
               
               
                   
                 BP_ALL 
                 201473_AT, 242794_AT, 21294          _AT, 201471_S_AT, 235739_AT, 20          960_S_AT, 213763_AT, 
               
               
                   
                   
                 1566901_AT, 200          7          _AT, 203665_AT, 2049          _S_AT, 201565_S_AT, 203753_AT, 204653_AT, 
               
               
                   
                   
                 225116_AT, 201466_S_AT, 225115_AT, 1555          32_S_AT; 222146_S_AT, 212124_AT, 22536          _AT, 
               
               
                   
                   
                 205312_AT, 20          37_S_AT, 20          61_S_AT, 21624          _S_AT, 212171_X_AT, 204622_X_AT, 235457_AT, 
               
               
                   
                   
                 201566_X_AT, 22          64_AT, 212387_AT, 218559_S_AT, 222670_S_AT, 210512_S_AT, 20          436_S_AT, 
               
               
                   
                   
                 211527_X_AT, 203751_X_AT, 244414_AT, 203140_AT, 242405_AT, 220266_S_AT, 20276          _AT, 
               
               
                   
                   
                 2132          1_AT, 224606_AT, 209189_AT, 210513_S_AT, 212386_AT, 225097_AT, 203752_S_AT, 
               
               
                   
                   
                 225557_AT, 217591_AT 
               
               
                   
                 GOTERM —   
                 213          91_S_AT, 201464_X_AT, 201465_S_AT, 219028_AT, 221          41_S_AT, 201473_AT, 242794_AT, 
               
               
                   
                 BP_ALL 
                 211352_S_AT, 212948_AT, 201471_S_AT, 23573          _AT, 20          960_S_AT, 213763_AT, 205067_AT, 
               
               
                   
                   
                 236561_AT, 220066_AT, 200          78_AT, 205          92_AT, 20          65_AT, 203753_AT, 225116_AT, 206157_AT, 
               
               
                   
                   
                 201466_S_AT, 1552914_A_AT, 207700_S_AT, 225115_AT, 1555          32_S_AT, 222146_S_AT, 212124_AT, 
               
               
                   
                   
                 22536          _AT, 205312_AT, 20          961_S_AT, 224          59_AT, 21624          _S_AT, 212171_X_AT, 39402_AT 
               
               
                   
                   
                 204622_X_AT, 205463_S_AT, 235457_AT, 2123          7_AT, 22          30_AT, 218559_S_AT, 222670_S_AT, 
               
               
                   
                   
                 210512_S_AT, 211527_X_AT, 244414_AT, 242405_AT, 220266_S_AT, 213281_AT, 224606_AT, 
               
               
                   
                   
                 2091          9_AT, 210513_S_AT, 203          35_AT, 2123          6_AT, 225097_AT, 225557_AT, 223394_AT 
               
               
                   
                 GOTERM —   
                 237252_AT, 213503_X_AT, 209555_S_AT, 208816_X_AT, 210427_X_AT, 211924_S_AT, 201590_X_AT, 
               
               
                   
                 BP_ALL 
                 214          66_AT, 203074_AT, 20          _AT, 204401_AT, 2054          _S_AT, 206          35_AT, 203          7_S_AT, 
               
               
                   
                   
                 22          766_AT, 235944_AT, 241929_AT, 210845_S_AT, 201005_AT 
               
               
                   
                 GOTERM —   
                 217173_S_AT, 37152_AT, 20          555_S_AT, 39402_AT, 219155_AT, 238649_AT, 20206          _S_AT, 
               
               
                   
                 BP_ALL 
                 212062_AT, 204401_AT, 226390_AT, 206          _S_AT, 22          766_AT, 214255_AT, 205067_AT, 226302_AT, 
               
               
                   
                   
                 241929_AT, 202067_S_AT, 201012_AT, 209122_AT 
               
               
                   
                 GOTERM —   
                 203665_AT, 203140_AT, 205          91_AT, 39402_AT, 205463_S_AT, 226218_AT, 223501_AT, 229          30_AT, 
               
               
                   
                 BP_ALL 
                 223502_S_AT, 204923_AT, 1552914_A_AT, 203233_AT, 222062_AT, 205067_AT, 2022          _S_AT, 
               
               
                   
                   
                 22          59_AT 
               
               
                   
                 GOTERM —   
                 237252_AT, 201464_X_AT, 201465_S_AT, 39402_AT, 202241_AT, 2132          3_AT, 1405_I_AT, 204655_AT, 
               
               
                   
                 BP_ALL 
                 20          189_AT, 201466_S_AT, 203          _AT, 211661_X_AT, 239          1          _X_AT, 203          7_S_AT, 2276          7_AT, 
               
               
                   
                   
                 205067_AT, 1555759_A_AT, 220066_AT 
               
               
                   
                 GOTERM —   
                 210495_X_AT, 2164          2_X_AT, 229221_AT, 212171_X_AT, 212014_X_AT, 211719_X_AT, 221731_X_AT, 
               
               
                   
                 MF_ALL 
                 210916_S_AT, 1557          05_S_AT, 201548_S_AT, 22          1          6_S_AT, 210512_S_AT, 220066_AT, 211527_X_AT, 
               
               
                   
                   
                 210          39_S_AT, 2044          9_S_AT, 20          490_S_AT, 204620_S_AT, 215646_S_AT, 20          619_S_AT, 210513_S_AT, 
               
               
                   
                   
                 209          35_X_AT, 212190_AT, 206157_AT, 209192_AT, 211571_S_AT, 212464_S_AT 
               
               
                   
                 GOTERM —   
                 210495_X_AT, 216442_X_AT, 229221_AT, 212171_X_AT, 212014_X_AT, 211719_X_AT, 221731_X_AT, 
               
               
                   
                 MF_ALL 
                 210916_S_AT, 1557905_S_AT, 20354          _S_AT, 22          1          6_S_AT, 210512_S_AT, 220066_AT, 211527_X_AT, 
               
               
                   
                   
                 210          39_S_AT, 2044          _S_AT, 204490_S_AT, 204620_S_AT, 215646_S_AT, 204619_S_AT, 210513_S_AT, 
               
               
                   
                   
                 20          35_X_AT, 212190_AT, 206157_AT, 209392_AT, 211571_S_AT, 212464_S_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 201465_S_AT, 37152_AT, 212298_AT, 219028_AT, 221841_S_AT, 204923_AT, 
               
               
                   
                 BP_ALL 
                 213763_AT, 205067_AT, 1566901_AT, 202          59_X_AT, 2022          4_S_AT, 236561_AT, 203729_AT, 
               
               
                   
                   
                 203665_AT, 239519_AT, 201565_S_AT, 225116_AT, 223502_S_AT, 201466_S_AT, 212143_S_AT, 
               
               
                   
                   
                 1552914_A_AT, 204035_AT, 225115_AT, 212124_AT, 225368_AT, 201005_AT, 224          59_AT, 
               
               
                   
                   
                 210095_S_AT, 201012_AT, 214211_AT, 212171_X_AT, 39402_AT, 205463_S_AT, 201566_X_AT, 
               
               
                   
                   
                 223501_AT, 22          30_AT, 200748_S_AT, 239818_X_AT, 203940_S_AT, 200921_S_AT, 210512_S_AT, 
               
               
                   
                   
                 200920_S_AT, 211527_X_AT, 203140_AT, 220266_S_AT, 202241_AT, 213281_AT, 210513_S_AT, 
               
               
                   
                   
                 23          669_AT, 225097_AT, 219257_S_AT, 223394_AT 
               
               
                   
                 GOTERM —   
                 213891_S_AT, 201464_X_AT, 201465_S_AT, 219028_AT, 221841_S_AT, 201473_AT, 242794_AT, 
               
               
                   
                 BP_ALL 
                 211352_S_AT, 21294          _AT, 201471_S_AT, 235739_AT, 20          960_S_AT, 213763_AT, 205067_AT, 
               
               
                   
                   
                 236561_AT, 220066_AT, 200          7          _AT, 205          91_AT, 20          665_AT, 20375          _AT, 225116_AT, 206157_AT, 
               
               
                   
                   
                 201466_S_AT, 1552914_A_AT, 207700_S_AT, 225115_AT, 1555832_S_AT, 222146_S_AT, 212124_AT, 
               
               
                   
                   
                 225368_AT, 205312_AT, 20          961_S_AT, 224859_AT, 216248_S_AT, 212171_X_AT, 39402_AT, 
               
               
                   
                   
                 204622_X_AT, 205463_S_AT, 235457_AT, 2123          7_AT, 229          30_AT, 21          559_S_AT, 222670_S_AT, 
               
               
                   
                   
                 210512_S_AT, 211527_X_AT, 244414_AT, 242405_AT, 220266_S_AT, 2132          1_AT, 224606_AT, 
               
               
                   
                   
                 209189_AT, 210513_S_AT, 203935_AT, 212386_AT, 225097_AT, 225557_AT, 223394_AT 
               
               
                   
                 GOTERM —   
                 1554992_AT, 203665_AT, 205          91_AT, 39402_AT, 21          34_S_AT, 238669_AT, 15565          3_A_AT, 
               
               
                   
                 BP_ALL 
                 240          65_AT, 206171_AT, 219257_S_AT, 205067_AT, 202071_AT, 200          78_AT, 201170_S_AT, 
               
               
                   
                   
                 2156          8_AT, 1562467_AT 
               
               
                   
                 GOTERM —   
                 203          65_AT, 205891_AT, 203140_AT, 222062_AT, 39402_AT, 217757_AT, 205067_AT, 220066_AT, 
               
               
                   
                 BP_ALL 
                 226218_AT, 204923_AT 
               
               
                   
                 GOTERM —   
                 202540_S_AT, 213891_S_AT, 201464_X_AT, 201465_S_AT, 212171_X_AT, 216248_S_AT, 209659_AT, 
               
               
                   
                 MF_ALL 
                 205463_S_AT, 204622_X_AT, 241722_X_AT, 20          923_S_AT, 201473_AT, 2123          7_AT, 229          30_AT, 
               
               
                   
                   
                 227107_AT, 235739_AT, 210512_S_AT, 236561_AT, 211527_X_AT, 200878_AT, 20          751_X_AT, 
               
               
                   
                   
                 1562467_AT, 20499          _S_AT, 202768_AT, 2132          1_AT, 221840_AT, 210513_S_AT, 1552553_A_AT, 
               
               
                   
                   
                 20918          _AT, 221012_S_AT, 203753_AT, 203922_S_AT, 204          53_AT, 204715_AT, 201466_S_AT, 
               
               
                   
                   
                 2          5295_AT, 203104_AT, 203935_AT, 201313_AT, 201995_AT, 2123          6_AT, 222146_S_AT, 
               
               
                   
                   
                 203752_S_AT, 202539_S_AT 
               
               
                   
                 GOTERM —   
                 212171_X_AT, 212298_AT, 63825_AT, 205463_S_AT, 229          30_AT, 205566_AT, 203940_S_AT, 
               
               
                   
                 BP_ALL 
                 2          1          _X_AT, 236561_AT, 210512_S_AT,           7100_AT, 231527_X_AT, 210839_S_AT, 22          490_AT, 
               
               
                   
                   
                 203665_AT, 203140_AT, 202241_AT, 210513_S_AT, 239519_AT, 212190_AT, 221          15_AT, 225337_AT, 
               
               
                   
                   
                 212343_S_AT, 219257_S_AT, 209392_AT, 210095_S_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 201465_S_AT, 21902          _AT, 212171_X_AT, 2122          _AT, 205463_S_AT, 229          30_AT, 
               
               
                   
                 BP_ALL 
                 213763_AT, 2026          6_S_AT, 226389_S_AT, 236561_AT, 210512_S_AT, 211527_X_AT, 221          40_AT, 
               
               
                   
                   
                 2132          1_AT, 2091          9_AT, 210513_S_AT, 239519_AT, 214054_AT, 203037_S_AT, 229116_AT, 
               
               
                   
                   
                 225738_AT, 2014          6_S_AT, 203935_AT, 203104_AT, 225115_AT, 225097_AT, 22536          _AT, 
               
               
                   
                   
                 20          37_S_AT, 225557_AT, 210173_AT 
               
               
                   
                 GOTERM —   
                 229221_AT, 214297_AT, 212171_X_AT, 209555_S_AT, 205463_S_AT, 212014_X_AT, 211924_S_AT, 
               
               
                   
                 CC_ALL 
                 214          66_AT, 226218_AT, 210916_S_AT, 229830_AT, 209994_S_AT, 206488_S_AT, 1557905_S_AT, 
               
               
                   
                   
                 23          542_AT, 210512_S_AT, 220066_AT, 211527_X_AT, 202071_AT, 2044          9_S_AT, 204736_S_AT, 
               
               
                   
                   
                 204490_S_AT, 220307_AT, 210513_S_AT, 209          35_X_AT, 1552914_A_AT, 204105_S_AT, 202756_S_AT, 
               
               
                   
                   
                 22          766_AT, 241929_AT, 210          45_S_AT, 224859_AT, 209993_AT 
               
               
                   
                 GOTERM —   
                 214211_AT, 201464_X_AT, 223723_AT, 201465_S_AT, 37152_AT, 210136_AT, 39402_AT, 
               
               
                   
                 BP_ALL 
                 241722_X_AT, 1405_I_AT, 241938_AT, 204661_AT, 34210_AT, 205099_S_AT, 200748_S_AT, 
               
               
                   
                   
                 20          01_AT, 205067_AT, 201925_S_AT, 1562          67_AT, 209906_AT, 216017_S_AT, 213281_AT, 
               
               
                   
                   
                 204655_AT, 201466_S_AT, 239451_AT, 15565          3_A_AT, 212803_AT, 1555759_A_AT, 241773_AT, 
               
               
                   
                   
                 201005_AT, 205098_AT 
               
               
                   
                 GOTERM —   
                 202540_S_AT, 37152_AT, 21902          _AT, 2279          _AT, 216834_AT, 20247          _AT, 211352_S_AT, 
               
               
                   
                 BP_ALL 
                 201471_S_AT, 213763_AT, 24          0_S_AT, 2263          9_S_AT, 205067_AT, 1566901_AT, 236561_AT, 
               
               
                   
                   
                 220066_AT, 202          _AT, 205891_AT, 203          5_AT, 20          891_AT, 225116_AT, 212143_S_AT, 
               
               
                   
                   
                 207700_S_AT, 225115_AT, 215602_AT, 22536          _AT, 202          _S_AT, 241773_AT, 243556_AT, 
               
               
                   
                   
                 2100          5_S_AT, 20253          _S_AT, 212171_X_AT, 218501_AT, 39402_AT, 227240_AT, 22339          _AT, 
               
               
                   
                   
                 239818_X_AT, 208893_S_AT, 219          45_AT, 219908_AT, 210512_S_AT, 2191          3_S_AT, 211527_X_AT, 
               
               
                   
                   
                 1554992_AT, 203140_AT, 20          92_S_AT, 202241_AT, 210513_S_AT, 1565754_X_AT, 22573          _AT, 
               
               
                   
                   
                 1565752_AT, 20          935_AT, 210258_AT, 227697_AT, 225097_AT, 217591_AT, 2156          _AT 
               
               
                   
                 GOTERM —   
                 212298_AT, 212171_X_AT, 63825_AT, 209555_S_AT, 39402_AT, 205463_S_AT, 228708_AT, 
               
               
                   
                 BP_ALL 
                 229830_AT, 227107_AT, 205566_AT, 204401_AT, 2064          _S_AT, 239          1          _X_AT, 203940_S_AT, 
               
               
                   
                   
                 205067_AT, 203548_S_AT, 210512_S_AT, 236561_AT, 220066_AT,           7100_AT, 211527_X_AT, 
               
               
                   
                   
                 210          39_S_AT, 228490_AT, 203665_AT, 205          91_AT, 203140_AT, 202241_AT, 239519_AT, 
               
               
                   
                   
                 210513_S_AT, 212190_AT, 204715_AT, 221          15_AT, 206157_AT, 212143_S_AT, 225337_AT, 
               
               
                   
                   
                 235669_AT, 235295_AT, 1556583_A_AT, 228766_AT, 219257_S_AT, 209392_AT, 241929_AT, 
               
               
                   
                   
                 210095_S_AT 
               
               
                   
                 GOTERM —   
                 203665_AT, 203140_AT, 203233_AT, 227062_AT, 217757_AT, 220066_AT, 22621          _AT, 224          59_AT, 
               
               
                   
                 BP_ALL 
                 1552914_A_AT 
               
               
                   
                 GOTERM —   
                 217173_S_AT, 37152_AT, 219155_AT, 209555_S_AT, 23          649_AT, 202068_S_AT, 212062_AT, 
               
               
                   
                 BP_ALL 
                 204401_AT, 226350_AT, 206          _S_AT, 22          766_AT, 214255_AT, 226302_AT, 241929_AT, 
               
               
                   
                   
                 202067_S_AT, 201012_AT, 209122_AT 
               
               
                   
                 GOTERM —   
                 227069_AT, 229221_AT, 37152_AT, 212298_AT, 210136_AT, 212014_X_AT, 221731_X_AT, 222          77_AT, 
               
               
                   
                 BP_ALL 
                 241938_AT, 210916_S_AT, 235739_AT, 202          28_S_AT, 1566901_AT, 230360_AT, 236561_AT, 
               
               
                   
                   
                 204141_AT, 204489_S_AT, 216017_S_AT, 204490_S_AT, 204998_S_AT, 20          620_S_AT, 201149_S_AT, 
               
               
                   
                   
                 239519_AT, 201147_S_AT, 209          35_X_AT, 232649_AT, 204653_AT, 212190_AT, 2204          4_AT, 
               
               
                   
                   
                 201005_AT, 243556_AT, 2119          6_AT, 233220_AT, 160020_AT, 212172_X_AT, 21624          _S_AT, 
               
               
                   
                   
                 204622_X_AT, 227240_AT, 202191_S_AT, 218559_S_AT, 1557905_S_AT, 204684_AT, 210512_S_AT, 
               
               
                   
                   
                 202          27_S_AT, 222670_S_AT, 211527_X_AT, 201150_S_AT, 204465_S_AT, 201248_S_AT, 1554          2_AT, 
               
               
                   
                   
                 220935_S_AT, 210512_S_AT, 2091          9_AT, 215646_S_AT, 204619_S_AT, 212372_AT, 204105_S_AT, 
               
               
                   
                   
                 229797_AT, 212          03_AT, 217279_X_AT, 215          8_AT, 211571_S_AT 
               
               
                   
                 GOTERM —   
                 2014          4_X_AT, 201465_S_AT, 37152_AT, 210136_AT, 2122          _AT, 2162          _S_AT, 39402_AT, 
               
               
                   
                 BP_ALL 
                 205463_S_AT, 204622_X_AT, 1405_I_AT, 241938_AT, 229          30_AT, 205099_S_AT, 227107_AT, 
               
               
                   
                   
                 235739_AT, 2026          _S_AT, 2046          4_AT, 219845_AT, 205067_AT, 2022          4_S_AT, 221463_AT, 
               
               
                   
                   
                 1562467_AT, 21          017_S_AT, 203665_AT, 205          1_AT, 213281_AT, 204655_AT, 239519_AT, 2091          9_AT, 
               
               
                   
                   
                 204715_AT, 201466_S_AT, 235295_AT, 15565          3_A_AT, 212          03_AT, 1555759_A_AT, 210173_AT, 
               
               
                   
                   
                 201005_AT, 20509          _AT 
               
               
                   
                 GOTERM —   
                 212171_X_AT, 212124_AT, 211962_S_AT, 210513_S_AT, 210512_S_AT, 201473_AT, 210173_AT, 
               
               
                   
                 BP_ALL 
                 211527_X_AT, 24193          _AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 201465_S_AT, 37152_AT, 219028_AT, 212171_X_AT, 212298_AT, 39402_AT, 
               
               
                   
                 BP_ALL 
                 205463_S_AT, 201566_X_AT, 223501_AT, 229          30_AT, 204923_AT, 213763_AT, 1566          01_AT, 
               
               
                   
                   
                 205067_AT, 236561_AT, 2022          4_S_AT, 210512_S_AT, 211527_X_AT, 203140_AT, 213281_AT, 
               
               
                   
                   
                 239519_AT, 201565_S_AT, 210513_S_AT, 225116_AT, 223502_S_AT, 201466_S_AT, 1552914_A_AT, 
               
               
                   
                   
                 204035_AT, 225115_AT, 225097_AT, 212124_AT, 219257_S_AT, 225368_AT, 224859_AT, 223394_AT 
               
               
                   
                 GOTERM —   
                 214211_AT, 201464_X_AT, 201465_S_AT, 37152_AT, 39402_AT, 221842_S_AT, 20074          _S_AT, 
               
               
                   
                 BP_ALL 
                 203940_S_AT, 23981          _X_AT, 200921_S_AT, 1566901_AT, 205067_AT, 202284_S_AT, 202859_X_AT, 
               
               
                   
                   
                 200920_S_AT, 203729_AT, 203665_AT, 203140_AT, 220266_S_AT, 213281_AT, 202241_AT, 
               
               
                   
                   
                 201466_S_AT, 1552914_A_AT, 212143_S_AT, 204035_AT, 201005_AT, 224859_AT, 210095_S_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 201465_S_AT, 229221_AT, 21902          _AT, 227948_AT, 212014_X_AT, 210916_S_AT, 
               
               
                   
                 BP_ALL 
                 201041_S_AT, 201471_S_AT, 235739_AT, 213763_AT, 217997_AT, 205067_AT, 202284_S_AT, 
               
               
                   
                   
                 236561_AT, 220066_AT, 204489_S_AT, 203665_AT, 204490_S_AT, 20499          _S_AT, 201149_S_AT, 
               
               
                   
                   
                 201147_S_AT, 209835_X_AT, 225116_AT, 223502_S_AT, 201466_S_AT, 212143_S_AT, 204035_AT, 
               
               
                   
                   
                 225115_AT, 215602_AT, 225368_AT, 243556_AT, 210095_S_AT, 205681_AT, 201012_AT, 
               
               
                   
                   
                 212171_X_AT, 216248_S_AT, 39402_AT, 21          501_AT, 204622_X_AT, 243797_AT, 241722_X_AT, 
               
               
                   
                   
                 227240_AT, 223501_AT, 2020          6_AT, 1557905_S_AT, 200921_S_AT, 210512_S_AT, 200920_S_AT, 
               
               
                   
                   
                 211527_X_AT, 201150_S_AT, 217996_AT, 201148_S_AT, 1554992_AT, 203140_AT, 213281_AT, 
               
               
                   
                   
                 210513_S_AT, 1552553_A_AT, 1565754_X_AT, 201044_X_AT, 225          42_AT, 1565752_AT, 203          35_AT, 
               
               
                   
                   
                 239451_AT, 227697_AT, 225097_AT, 219257_S_AT, 2156          _AT 
               
               
                   
                 GOTERM —   
                 205          91_AT, 203140_AT, 203233_AT, 39402_AT, 205067_AT, 2022          4_S_AT, 226218_AT, 223501_AT, 
               
               
                   
                 BP_ALL 
                 224          59_AT, 223502_S_AT, 1552914_A_AT, 20          923_AT 
               
               
                   
                 GOTERM 
                 203140_AT, 205891_AT, 203665_AT, 39402_AT, 22621          _AT, 223501_AT, 223502_S_AT, 20          923_AT, 
               
               
                   
                 BP_ALL 
                 1552914_A_AT, 203233_AT, 222062_AT, 205067_AT, 2022          4_S_AT, 224          59_AT 
               
               
                   
                 GOTERM —   
                 216442_X_AT, 210495_X_AT, 212271_X_AT, 22794          _AT, 210513_S_AT, 211719_X_AT, 1565754_X_AT, 
               
               
                   
                 BP_ALL 
                 202191_S_AT, 212372_AT, 1565752_AT, 215602_AT, 214255_AT, 210512_S_AT, 211527_X_AT, 
               
               
                   
                   
                 212464_S_AT 
               
               
                   
                 GOTERM —   
                 213391_S_AT, 201454_X_AT, 201465_S_AT, 219028_AT, 221          41_S_AT, 201473_AT, 242794_AT 
               
               
                   
                 BP_ALL 
                 211352_S_AT, 212948_AT, 201471_S_AT, 235739_AT, 20          960_S_AT, 213763_AT, 205067_AT 
               
               
                   
                   
                 1554453_AT, 236561_AT, 200          78_AT, 205891_AT, 203753_AT, 225116_AT, 206157_AT, 201466_S_AT 
               
               
                   
                   
                 207700_S_AT, 225115_AT, 1555832_S_AT, 222146_S_AT, 212124_AT, 225368_AT, 205312_AT, 
               
               
                   
                   
                 20          961_S_AT, 216248_S_AT, 212171_X_AT, 39402_AT, 205463_S_AT, 204622_X_AT, 235457_AT, 
               
               
                   
                   
                 2123          7_AT, 229          30_AT, 218559_S_AT, 222670_S_AT, 210512_S_AT, 211527_X_AT, 244414_AT, 
               
               
                   
                   
                 242405_AT, 220266_S_AT, 213281_AT, 224606_AT, 209189_AT, 210513_S_AT, 203935_AT, 
               
               
                   
                   
                 212386_AT, 225097_AT, 225557_AT, 223394_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 201455_S_AT, 229221_AT, 219028_AT, 227946_AT, 212014_X_AT, 210916_S_AT, 
               
               
                   
                 BP_ALL 
                 201041_S_AT, 201471_S_AT, 235739_AT, 213763_AT, 217997_AT, 205067_AT, 2022          4_S_AT, 
               
               
                   
                   
                 23          561_AT, 220066_AT, 2044          9_S_AT, 203665_AT, 204490_S_AT, 20499          _S_AT, 201149_S_AT, 
               
               
                   
                   
                 201147_S_AT, 209835_X_AT, 225116_AT, 223502_S_AT, 201466_S_AT, 212143_S_AT, 204035_AT, 
               
               
                   
                   
                 225115_AT, 215602_AT, 225368_AT, 243556_AT, 210095_S_AT, 2056          1_AT, 201012_AT, 
               
               
                   
                   
                 212171_X_AT, 21624          _S_AT, 39402_AT, 21          501_AT, 204622_X_AT, 243797_AT, 241722_X_AT, 
               
               
                   
                   
                 227240_AT, 223501_AT, 202          6_AT, 1557905_S_AT, 200922_S_AT, 210512_S_AT, 200920_S_AT, 
               
               
                   
                   
                 211527_X_AT, 201150_S_AT, 217996_AT, 201148_S_AT, 1554992_AT, 203140_AT, 213281_AT, 
               
               
                   
                   
                 210513_S_AT, 1552553_A_AT, 1565754_X_AT, 201044_X_AT, 225842_AT, 1565752_AT, 203935_AT, 
               
               
                   
                   
                 239451_AT, 227697_AT, 225097_AT, 219257_S_AT, 215688_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 201465_S_AT, 229221_AT, 219028_AT, 227948_AT, 212014_X_AT, 210916_S_AT, 
               
               
                   
                 BP_ALL 
                 201041_S_AT, 201471_S_AT, 235739_AT, 213763_AT, 217997_AT, 205067_AT, 2022          4_S_AT, 
               
               
                   
                   
                 236561_AT, 220066_AT, 2044          9_S_AT, 203665_AT, 204490_S_AT, 20499          _S_AT, 201149_S_AT, 
               
               
                   
                   
                 201147_S_AT, 209835_X_AT, 225116_AT, 223502_S_AT, 201466_S_AT, 212143_S_AT, 204035_AT, 
               
               
                   
                   
                 225115_AT, 215602_AT, 225368_AT, 243556_AT, 210095_S_AT, 205681_AT, 201012_AT, 
               
               
                   
                   
                 212171_X_AT, 21624          _S_AT, 39402_AT, 21          501_AT, 204622_X_AT, 243797_AT, 241722_X_AT, 
               
               
                   
                   
                 227240_AT, 223501_AT, 2020          6_AT, 1557905_S_AT, 200921_S_AT, 210512_S_AT, 200920_S_AT, 
               
               
                   
                   
                 211527_X_AT, 201150_S_AT, 217996_AT, 201248_S_AT, 1554992_AT, 203140_AT, 2132          1_AT, 
               
               
                   
                   
                 210513_S_AT, 1552553_A_AT, 1565754_X_AT, 201044_X_AT, 225842_AT, 1565752_AT, 203935_AT, 
               
               
                   
                   
                 239451_AT, 227697_AT, 225097_AT, 219257_S_AT, 2156          _AT 
               
               
                   
                 GOTERM —   
                 205891_AT, 203140_AT, 217757_AT, 203508_AT, 204          55_AT, 1405_I_AT, 1555759_A_AT, 224859_AT, 
               
               
                   
                 BP_ALL 
                 203939_AT, 1552914_A_AT 
               
               
                   
                 GOTERM —   
                 204035_AT, 212171_X_AT, 210513_S_AT, 210512_S_AT, 202859_X_AT, 211527_X_AT, 20          27_S_AT 
               
               
                   
                 BP_ALL 
                   
               
               
                   
                 GOTERM —   
                 202540_S_AT, 37152_AT, 215028_AT, 2279          _AT, 216834_AT, 202478_AT, 211352_S_AT, 
               
               
                   
                 BP_ALL 
                 201471_S_AT, 213763_AT, 224480_S_AT, 226389_S_AT, 205067_AT, 15          6901_AT, 236561_AT, 
               
               
                   
                   
                 2200          6_AT, 201170_S_AT, 2023          _AT, 203          65_AT, 2058          1_AT, 20          91_AT, 225116_AT, 
               
               
                   
                   
                 212143_S_AT, 207700_S_AT, 225115_AT, 213602_AT, 22536          _AT, 2029          _S_AT, 241773_AT, 
               
               
                   
                   
                 243556_AT, 210095_S_AT, 202539_S_AT, 212171_X_AT, 218501_AT, 39402_AT, 227240_AT, 
               
               
                   
                   
                 2232          _AT, 239          15_X_AT, 20          93_S_AT, 219845_AT, 219908_AT, 210512_S_AT, 219183_S_AT, 
               
               
                   
                   
                 211527_X_AT, 1562467_AT, 1554992_AT, 203140_AT, 20          92_S_AT, 202241_AT, 210513_S_AT, 
               
               
                   
                   
                 1565754_X_AT, 22573          _AT, 1565752_AT, 203935_AT, 210258_AT, 227697_AT, 225097_AT, 
               
               
                   
                   
                 217591_AT, 2156          _AT 
               
               
                   
                 GOTERM —   
                 205891_AT, 203140_AT, 203233_AT, 39402_AT, 205067_AT, 202284_S_AT, 226218_AT, 223501_AT, 
               
               
                   
                 BP_ALL 
                 224859_AT, 223502_S_AT, 1552914_A_AT, 204923_AT 
               
               
                   
                 GOTERM —   
                 213503_X_AT, 21902          _AT, 39402_AT, 205463_S_AT, 22794          _AT, 1405_I_AT, 210427_X_AT, 
               
               
                   
                 BP_ALL 
                 229830_AT, 213763_AT, 205067_AT, 220066_AT, 20          436_S_AT, 203939_AT, 203140_AT, 205          91_AT, 
               
               
                   
                   
                 217757_AT, 20          16_X_AT, 204655_AT, 201590_X_AT, 225116_AT, 1552914_A_AT, 225115_AT, 
               
               
                   
                   
                 225097_AT, 203508_AT, 225368_AT, 1555759_A_AT, 234          59_AT 
               
               
                   
                 GOTERM —   
                 160020_AT, 216017_S_AT, 201069_AT, 21350          _X_AT, 210427_X_AT, 201590_X_AT, 22421          _S_AT, 
               
               
                   
                 BP_ALL 
                 204          3_AT, 212143_S_AT, 206          35_AT, 218502_S_AT, 201995_AT, 203752_S_AT, 202          28_S_AT, 
               
               
                   
                   
                 212          03_AT, 236561_AT, 202827_S_AT, 223092_AT, 225557_AT, 217279_AT, 222651_S_AT, 
               
               
                   
                   
                 2100          5_S_AT, 1569149_AT, 203751_X_AT 
               
               
                   
                 GOTERM —   
                 203          _AT, 214453_S_AT, 20          655_AT, 1405_I_AT, 1555759_A_AT, 20          436_S_AT, 211676_S_AT, 
               
               
                   
                 BP_ALL 
                 202086_AT, 229          37_X_AT, 208438_S_AT, 213293_S_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 201465_S_AT, 229221_AT, 37152_AT, 212171_X_AT, 224967_AT, 205463_S_AT, 
               
               
                   
                 BP_ALL 
                 221841_S_AT, 212014_X_AT, 211924_S_AT, 214          66_AT, 201473_AT, 222877_AT, 210916_S_AT, 
               
               
                   
                   
                 229          30_AT, 1557905_S_AT, 206          35_AT, 219          45_AT, 1566901_AT, 210512_S_AT, 211527_X_AT, 
               
               
                   
                   
                 1562467_AT, 201150_S_AT, 204465_S_AT, 201148_S_AT, 2044          9_S_AT, 204490_S_AT, 220266_S_AT, 
               
               
                   
                   
                 2132          1_AT, 201149_S_AT, 210          13_S_AT, 201147_S_AT, 209          35_X_AT, 204653_AT, 201466_S_AT, 
               
               
                   
                   
                 212372_AT, 203935_AT, 204881_S_AT, 201995_AT, 21          45_S_AT, 201324_AT, 201012_AT 
               
               
                   
                 GOTERM —   
                 214211_AT, 209906_AT, 223723_AT, 203665_AT, 39402_AT, 1405_I_AT, 204655_AT, 34230_AT, 
               
               
                   
                 BP_ALL 
                 204661_AT, 20          099_S_AT, 20074          _S_AT, 239451_AT, 15565          3_A_AT, 205067_AT, 1555759_A_AT, 
               
               
                   
                   
                 241773_AT, 201925_S_AT, 20509          _AT 
               
               
                   
                 GOTERM —   
                 216442_X_AT, 210          95_X_AT, 21229          _AT, 210136_AT, 212171_X_AT, 22794          _AT, 23          519_AT, 
               
               
                   
                 BP_ALL 
                 210513_S_AT, 211719_X_AT, 1565754_X_AT, 202191_S_AT, 212372_AT, 1565752_AT, 204105_S_AT, 
               
               
                   
                   
                 215602_AT, 214255_AT, 210512_S_AT, 211527_X_AT, 22464_S_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 201465_S_AT, 39402_AT, 20546          _S_AT, 2112          1_AT, 1405_I_AT, 204655_AT, 
               
               
                   
                 BP_ALL 
                 2091          9_AT, 201473_AT, 229          30_AT, 201          66_S_AT, 20          4_S_AT, 201315_AT, 227697_AT, 
               
               
                   
                   
                 155658          _A_AT, 205067_AT, 2022          4_S_AT, 1555759_A_AT, 20          2_AT, 207          19_S_AT, 209122_AT 
               
               
                   
                 GOTERM —   
                 160020_AT, 229221_AT, 227          9_AT, 212171_X_AT, 21229          _AT, 205463_S_AT, 212014_X_AT, 
               
               
                   
                 BP_ALL 
                 210916_S_AT, 219          30_AT, 1557905_S_AT, 202          2          _S_AT, 1566          01_AT, 236561_AT, 210512_S_AT, 
               
               
                   
                   
                 202          27_S_AT, 211527_X_AT, 200          7          _AT, 204          9_S_AT, 204490_S_AT, 210513_S_AT, 235519_AT, 
               
               
                   
                   
                 20          35_X_AT, 204653_AT, 203935_AT, 217279_X_AT, 203529_AT 
               
               
                   
                 GOTERM —   
                 219028_AT, 212171_X_AT, 216248_S_AT, 39402_AT, 204622_X_AT, 241722_X_AT, 223501_AT, 
               
               
                   
                 BP_ALL 
                 201471_S_AT, 235739_AT, 213763_AT, 205067_AT, 236561_AT, 202284_S_AT, 210512_S_AT, 
               
               
                   
                   
                 211527_X_AT, 203140_AT, 203665_AT, 20499          _S_AT, 210513_S_AT, 225116_AT, 223502_S_AT, 
               
               
                   
                   
                 204035_AT, 203935_AT, 225115_AT, 239451_AT, 227697_AT, 225097_AT, 219257_S_AT, 22536          _AT, 
               
               
                   
                   
                 201012_AT, 205681_AT 
               
               
                   
                 GOTERM —   
                 212171_X_AT, 39402_AT, 216243_S_AT, 1405_I_AT, 204655_AT, 210513_S_AT, 223501_AT, 
               
               
                   
                 MF_ALL 
                 223502_S_AT, 204035_AT, 212657_S_AT, 205067_AT, 210512_S_AT, 1555759_A_AT, 202859_X_AT, 
               
               
                   
                   
                 221463_AT, 211527_X_AT, 209827_S_AT 
               
               
                   
                 GOTERM —   
                 205463_S_AT, 212124_AT, 219257_S_AT, 1566901_AT, 2022          4_S_AT, 229          30_AT 
               
               
                   
                 BP_ALL 
                   
               
               
                   
                 GOTERM —   
                 20114          _S_AT, 216442_X_AT, 210495_X_AT, 21342          _S_AT, 212171_X_AT, 213503_X_AT, 
               
               
                   
                 CC_ALL 
                 20          16_X_AT, 201149_S_AT, 210513_S_AT, 210427_X_AT, 201147_S_AT, 201590_X_AT, 211719_X_AT, 
               
               
                   
                   
                 235944_AT, 210512_S_AT, 211527_X_AT, 201150_S_AT, 212464_S_AT 
               
               
                   
                 KEGG —   
                 237252_AT, 209906_AT, 203          87_S_AT, 217757_AT, 211924_S_AT, 217552_X_AT, 214866_AT, 
               
               
                   
                 PATHWAY 
                 210845_S_AT, 201925_S_AT, 203          _AT 
               
               
                   
                 GOTERM —   
                 20114          _S_AT, 21          442_X_AT, 210495_X_AT, 212171_X_AT, 213503_X_AT, 208816_X_AT, 
               
               
                   
                 CC_ALL 
                 201149_S_AT, 210513_S_AT, 210427_X_AT, 201147_S_AT, 201590_X_AT, 211719_X_AT, 235944_AT, 
               
               
                   
                   
                 210512_S_AT, 211527_X_AT, 201150_S_AT, 212464_S_AT 
               
               
                   
                 GOTERM —   
                 219028_AT, 212171_X_AT, 216248_S_AT, 39402_AT, 204622_X_AT, 241722_X_AT, 223501_AT, 
               
               
                   
                 BP_ALL 
                 201471_S_AT, 235739_AT, 213763_AT, 205067_AT, 236561_AT, 2022          4_S_AT, 210512_S_AT, 
               
               
                   
                   
                 211527_X_AT, 203140_AT, 203665_AT, 2049          _S_AT, 210513_S_AT, 225116_AT, 223502_S_AT, 
               
               
                   
                   
                 204035_AT, 203935_AT, 225115_AT, 239451_AT, 227697_AT, 225097_AT, 219257_S_AT, 225368_AT, 
               
               
                   
                   
                 201012_AT, 205681_AT 
               
               
                   
                 GOTERM —   
                 21902          _AT, 212171_X_AT, 216248_S_AT_S_AT, 39402_AT, 204622_X_AT, 241722_X_AT, 223501_AT, 
               
               
                   
                 BP_ALL 
                 201471_S_AT, 235739_AT, 213763_AT, 205067_AT, 236561_AT, 202284_S_AT, 210512_S_AT, 
               
               
                   
                   
                 211527_X_AT, 203140_AT, 203665_AT, 204998_S_AT, 210513_S_AT, 225116_AT, 223502_S_AT, 
               
               
                   
                   
                 204035_AT, 203935_AT, 225115_AT, 239451_AT, 227697_AT, 225097_AT, 219257_S_AT, 225368_AT, 
               
               
                   
                   
                 201012_AT, 2056          1_AT 
               
               
                   
                 GOTERM —   
                 203140_AT, 39402_AT, 205067_AT, 202284_S_AT, 223501_AT, 224859_AT, 223502_S_AT, 
               
               
                   
                 BP_ALL 
                 155291_A_AT, 204923_AT 
               
               
                   
                 GOTERM —   
                 203140_AT, 39402_AT, 205067_AT, 2022          _S_AT, 223501_AT, 224          59_AT, 223502_S_AT, 
               
               
                   
                 BP_ALL 
                 1552914_A_AT, 204923_AT 
               
               
                   
                 GOTERM —   
                 203140_AT, 39402_AT, 205067_AT, 2022          4_S_AT, 223501_AT, 224          59_AT, 223502_S_AT, 
               
               
                   
                 BP_ALL 
                 1552914_A_AT, 204923_AT 
               
               
                   
                 GOTERM —   
                 216442_X_AT, 210495_X_AT, 212171_X_AT, 39402_AT, 209555_S_AT, 217757_AT, 205463_S_AT, 
               
               
                   
                 CC_ALL 
                 228708_AT, 210513_S_AT, 209549_AT, 211719_X_AT, 229          30_AT, 2064          8_S_AT, 2046          4_AT, 
               
               
                   
                   
                 22          766_AT, 205067_AT, 210512_S_AT, 241          29_AT, 202005_AT, 211527_X_AT, 212464_S_AT 
               
               
                   
                 GOTERM —   
                 201464_X_AT, 213          91_S_AT, 201465_S_AT, 219028_AT, 221          41_S_AT, 201473_AT, 242794_AT, 
               
               
                   
                 BP_ALL 
                 211352_S_AT, 21294          _AT, 201471_S_AT, 235739_AT, 20          960_S_AT, 213763_AT, 236561_AT, 
               
               
                   
                   
                 200          7          _AT, 201753_AT, 225116_AT, 201466_S_AT, 223502_S_AT, 207700_S_AT, 225115_AT, 
               
               
                   
                   
                 1555          32_S_AT, 222146_S_AT, 212124_AT, 22536          _AT, 205312_AT, 20          961_S_AT, 212171_X_AT, 
               
               
                   
                   
                 21          2          _S_AT, 204622_X_AT_, 235457_AT, 22          64_AT, 22350          _AT, 2123          7_AT, 21          559_S_AT, 
               
               
                   
                   
                 210512_S_AT, 212670_S_AT, 211527_X_AT, 24          14_AT, 220266_S_AT, 242405_AT, 2132          1_AT, 
               
               
                   
                   
                 224606_AT, 210513_S_AT, 2091          9_AT, 203935_AT, 2123          6_AT, 225097_AT, 225557_AT, 2233          4_AT 
               
               
                   
                 GOTERM —   
                 213          91_S_AT, 201464_X_AT, 201465_S_AT, 215028_AT, 221          41_S_AT, 201473_AT, 242794_AT, 
               
               
                   
                 BP_ALL 
                 211352_S_AT, 21294          _AT, 201471_S_AT, 235739_AT, 20          960_S_AT, 213763_AT, 2050          7_AT, 
               
               
                   
                   
                 236561_AT, 200          78_AT, 203665_AT, 203753_AT, 225116_AT, 201466_S_AT, 1552914_A_AT, 
               
               
                   
                   
                 207700_S_AT, 225115_AT, 1555          32_S_AT, 222146_S_AT, 212124_AT, 2253          _AT, 205312_AT, 
               
               
                   
                   
                 20          961_S_AT, 224          59_AT, 21624          _S_AT, 212171_X_AT, 39402_AT, 205463_S_AT, 204622_X_AT, 
               
               
                   
                   
                 235457_AT, 212387_AT, 229          30_AT, 218559_S_AT, 222670_S_AT, 210512_S_AT, 211527_X_AT, 
               
               
                   
                   
                 244414_AT, 242405_AT, 220266_S_AT, 2132          1_AT, 224606_AT, 2091          9_AT, 210513_S_AT, 
               
               
                   
                   
                 203935_AT, 2123          6_AT, 225097_AT, 225557_AT, 223394_AT 
               
               
                   
                 GOTERM —   
                 203665_AT, 203140_AT, 205891_AT, 213503_X_AT, 212171_X_AT, 205463_S_AT, 20          16_X_AT, 
               
               
                   
                 BP_ALL 
                 210427_X_AT, 210513_S_AT, 201590_X_AT, 229          30_AT, 206          35_AT, 210512_S_AT, 220066_AT, 
               
               
                   
                   
                 211527_X_AT 
               
               
                   
                 GOTERM —   
                 209906_AT, 39402_AT, 15565          3_A_AT, 205067_AT, 241773_AT, 201925_S_AT, 204661_AT, 34230_AT, 
               
               
                   
                 BP_ALL 
                 205099_S_AT, 20609          _AT 
               
               
                   
                 GOTERM —   
                 160020_AT, 201069_AT, 216017_S_AT, 212143_S_AT, 206          35_AT, 201995_AT, 203752_S_AT, 
               
               
                   
                 BP_ALL 
                 202          2          _S_AT, 212803_AT, 202          27_S_AT, 217279_X_AT, 210095_S_AT, 203751_X_AT, 1569149_AT 
               
               
                   
               
               
                             indicates data missing or illegible when filed 
               
             
          
         
       
     
         [0385]    The gene expression patterns induced by Copaxone® and Polimunol treatment were compared directly. The differential expression results were filtered based on the variability in observed control treatment effects relative to previous studies, to obtain a conservative subset of highest-confidence probesets. These analyses found that 27 highest-confidence probesets, representing 21 distinct genes, differed significantly by adjusted p value in expression between the two treatments (14 probesets downregulated, 13 upregulated by Polimunol relative to Copaxone). The upregulated and downregulated probesets are illustrated in Table 13 and Table 14, respectively. 
         [0000]    
       
         
               
             
               
               
               
               
               
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 13 
               
             
             
               
                   
               
               
                 Human monocyte study: probesets upregulated by Polimunol 
               
               
                 relative to Copaxone ® 
               
             
          
           
               
                 ID 
                 Gene 
                 raw.FC 
                 AveExpr 
                 P.Value 
                 adj.P.Val 
               
               
                   
               
             
          
           
               
                 202436_s_at 
                 CYP1B1 
                 1.328778115 
                 10.99251935 
                 2.76E−15 
                 1.51E−10 
               
               
                 202435_s_at 
                 CYP1B1 
                 1.291947504 
                 11.10690276 
                 1.98E−11 
                 2.70E−07 
               
               
                 202434_s_at 
                 CYP1B1 
                 1.34300307 
                 8.896124188 
                 5.54E−10 
                 3.79E−06 
               
               
                 229055_at 
                 GPR68 
                 1.233303306 
                 7.906128859 
                 3.58E−09 
                 1.50E−05 
               
               
                 202437_s_at 
                 CYP1B1 
                 1.283470087 
                 11.35502759 
                 5.53E−09 
                 1.96E−05 
               
               
                 212665_at 
                 TIPARP 
                 1.170151206 
                 9.316307674 
                 2.29E−07 
                 0.000543566 
               
               
                 1554966_a_at 
                 DOC1 
                 1.127401263 
                 8.443050186 
                 5.83E−07 
                 0.001274168 
               
               
                 204684_at 
                 NPTX1 
                 1.121904593 
                 10.50026157 
                 4.27E−06 
                 0.00556324 
               
               
                 229354_at 
                 PDCD6 
                 1.082379299 
                 10.56416164 
                 8.47E−06 
                 0.009858651 
               
               
                   
                 /// AHRR 
               
               
                 206710_s_at 
                 EPB41L3 
                 1.17828072 
                 6.683285506 
                 3.11E−05 
                 0.021766496 
               
               
                 204135_at 
                 DOC1 
                 1.093724798 
                 8.540804821 
                 4.46E−05 
                 0.028883673 
               
               
                 1569690_at 
                 CCDC36 
                 1.140648392 
                 5.595578016 
                 5.04E−05 
                 0.030714439 
               
               
                 211067_s_at 
                 GAS7 
                 1.080052886 
                 9.66677524 
                 5.29E−05 
                 0.031621345 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
               
               
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 14 
               
             
             
               
                   
               
               
                 Human monocyte study: probesets downregulated by Polimunol 
               
               
                 relative to Copaxone ® 
               
             
          
           
               
                 ID 
                 Gene 
                 raw.FC 
                 AveExpr 
                 P.Value 
                 adj.P.Val 
               
               
                   
               
             
          
           
               
                 230927_at 
                 — 
                 −1.171546521 
                 6.290190151 
                 2.87E−06 
                 0.004124895 
               
               
                 206170_at 
                 ADRB2 
                 −1.142744253 
                 8.033661912 
                 7.30E−06 
                 0.008675631 
               
               
                 228826_at 
                 RNF43 
                 −1.090334004 
                 8.930697832 
                 9.19E−06 
                 0.010052917 
               
               
                 1554676_at 
                 PRG1 
                 −1.337462167 
                 7.452885159 
                 1.08E−05 
                 0.010571079 
               
               
                 1557359_at 
                 LOC285758 
                 −1.113608349 
                 9.441580738 
                 1.43E−05 
                 0.012763184 
               
               
                 229934_at 
                 — 
                 −1.146000763 
                 9.629181433 
                 1.67E−05 
                 0.013799705 
               
               
                 244190_at 
                 THAP5 
                 −1.235324953 
                 3.96404755 
                 1.70E−05 
                 0.013885917 
               
               
                 1556346_at 
                 COTL1 
                 −1.23259647 
                 9.131189047 
                 1.97E−05 
                 0.01563098 
               
               
                 215111_s_at 
                 TSC22D1 
                 −1.115773148 
                 9.642583368 
                 2.19E−05 
                 0.016510136 
               
               
                 235274_at 
                 — 
                 −1.142519223 
                 7.012670757 
                 2.86E−05 
                 0.020344359 
               
               
                 1558782_a_at 
                 LOC644137 
                 −1.13456131 
                 8.05846686 
                 3.69E−05 
                 0.024635148 
               
               
                 201147_s_at 
                 TIMP3 
                 −1.069861862 
                 11.50473352 
                 5.32E−05 
                 0.031621345 
               
               
                 224559_at 
                 MALAT1 
                 −1.221208621 
                 9.943150851 
                 7.51E−05 
                 0.039950998 
               
               
                 210592_s_at 
                 SAT1 
                 −1.20105501 
                 9.927587911 
                 8.05E−05 
                 0.042336898 
               
               
                   
               
             
          
         
       
     
         [0386]    The gene with the highest fold change among those upregulated by Polimunol relative to Copaxone® was CYP1B1 (adj p&lt;1.5e-10), a member of the cytochrome P450 superfamily of enzymes. All four present probesets for this gene in this study showed similar results, as exemplified in Table 13. As shown in  FIG. 25 a   , CYP1B1 is significantly upregulated by Polimunol stimulation in human THP-1 monocyte cell line compared to Copaxone® stimulation at 6 hours. A second example is shown in Table 13 and  FIG. 25 b   , a probeset for GPR68 which was also upregulated by Polimunol relative to Copaxone® (adj p&lt;1.5e-5). Two probesets for the DOC1 gene were significantly upregulated by Polimunol relative to Copaxone, as shown in Table 13. 
         [0387]    One of the probesets downregulated by Polimunol relative to Copaxone® was ADRB2, the gene encoding the beta-2 adrenergic receptor. As shown in  FIG. 26 , ADRB2 is significantly downregulated by Polimunol stimulation in human THP-1 monocyte cell line compared to Copaxone® stimulation at 6 hours. 
       Discussion 
     Example 9 
       [0388]    Copaxone® treatment was compared with treatment with the purported generic Polimunol (manufactured by Synthon), as well as a mannitol control. More than 80% of the pathways that enriched among top upregulated genes in the previous study were also enriched among top upregulated genes in the current study. The results show concordance with the earlier study and confirm the gene expression patterns associated with Copaxone treatment of human monocytes—i.e. the complex, yet consistent mode of action of Copaxone® in this immunological cell type. 
         [0389]    As an example at the individual gene level, IL1RN was significantly upregulated (adjusted p 2.8e-10), consistent with the previous study described in Example 1. This gene encodes for the protein IL-1ra, which inhibits the activities of pro-inflammatory cytokines IL-1a and IL-1b. 
         [0390]    Overall, the results demonstrated that the effects of the complex biological mechanism of Copaxone® observed in prior studies were mechanistically consistent with the effects observed in this study, corroborating the validity of this approach for studying glatiramoid functionality in treatment paradigms. 
         [0391]    The study also identified significant differences between Copaxone® and Synthon&#39;s Polimunol. The results show that 27 highest-confidence probesets, representing 21 distinct genes, differed significantly by adjusted p value in expression between the two treatments (14 probesets downregulated, 13 upregulated by Polimunol relative to Copaxone). 
         [0392]    The gene with the highest fold change among those upregulated by Polimunol relative to Copaxone® was CYP1B1 (adj p&lt;1.5e-10), a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism. 
         [0393]    A second example is a probeset for GPR68 which was also upregulated by Polimunol relative to Copaxone® (adj p&lt;1.5e-5). After traumatic brain injury, cerebral cortical astrocytes abundantly expressed GPR68, suggesting a role in reactive astrogliosis. 
         [0394]    Two probesets for the DOC1 gene were significantly upregulated by Polimunol relative to Copaxone®. DOC1 is also known as CDK2AP1, or cyclin-dependent kinase 2 associated protein 1. DOC1 has been implicated as a locus for susceptibility to MS. (International Multiple Sclerosis Genetics Consortium (IMSGC), Genes Immun., 2010). One of the probesets downregulated by Polimunol relative to Copaxone was ADRB2, the gene encoding the beta-2 adrenergic receptor. Agonists for this receptor have been reported to affect antigen cross-presentation by dendritic cells (Hervé et al, J Immunol, 2013), alter cytokine secretion in human PBMC (Hilbert et al, Plos One, 2013), and change the proportions of myeloid cells in mouse brain under TNFα treatment (Laureys et al, J Neuroinflammation, 2014). In addition, signaling via this receptor in FOXP3+ regulatory T cells has been shown to enhance the suppressive function of these cells (Guereschi et al, Eur J Immunol, 2013). This functionality coupled with the observed expression levels of ADRB2 in  FIG. 26  warrants further investigation. 
         [0395]    These initial studies show clear and significant differences between Polimunol and Copaxone® in terms of impact on genomic profiling, including expression of genes with relevance for safety. Follow-on experiments are currently underway in both THP-1 cells and other model systems to further elucidate the differences identified to date. Substantial differences between Polimunol and Copaxone® were also identified using physicochemical methods and biological methods. Therefore, the gene expression differences described here, albeit subtle in terms of fold change, may represent chronic treatment effects that could have a clinically significant impact, and warrant further investigation in the interest of keeping MS patients safe. 
       Example 10 
     Differences in Gene Expression Induced by Polimunol Versus Branded GA in Mouse Splenocyte Gene Expression Studies 
       [0396]    Immunological cells, particularly T cells, are critical to the antigenic mechanism of action of Copaxone®, thus post-treatment gene expression modulation needs to examine such relevant cell types, including lymphocytes. 
         [0397]    As one approach to modeling these effects, a splenocyte system was utilized, in which mice were first immunized with either Copaxone® or Polimunol, and then sacrificed, having the splenocytes stimulated ex-vivo with Copaxone®, Polimunol, or medium. This model was used to simulate switching between medications compared with consistent use of one medicine or the other. A total of 157 samples were tested, and gene expression was measured using the Mouse Genome 430 2.0 Affymetrix chip. 
         [0398]    Some similarities are observed between the genes modulated by Copaxone® in a mouse splenocyte model and in a human monocyte (THP-1) model: a prior study indicated that 1,378 genes were modulated by 
         [0399]    Copaxone in both systems, while another 6,691 were modulated only in splenocytes and another 2,121 were modulated only in THP-1 cells (MSBoston Joint ACTRIMS-ECTRIMS 2014 Meeting, P282). These findings indicate that the majority of the impact of glatiramoids is cell type and tissue specific, including different interactions with lymphocytes versus antigen presenting cells, and thus several different immunologically relevant model systems are required to study the various implications of treatment with this NBCD. 
       Copaxone®-Modulated Genes Mechanism of Action (MoA) 
       [0400]    Analyzing splenocytes from mice immunized by Copaxone® and later activated with Copaxone®, 16,647 probesets were significantly modulated relative to medium (8,342 upregulated and 8,305 downregulated). The fact that over one third of the total probesets expressed in this tissue (i.e. 22,524 probesets called present on the chip) are significantly downregulated, and similarly over one third significantly upregulated, by Copaxone® treatment demonstrates the complexity of Copaxone&#39;s mechanism of action in this model system. 
         [0401]    Copaxone® treatment upregulated key anti-inflammatory cytokines I110 and 114 (adj p&lt;2.3e-24 and 5.1e-35, respectively;  FIG. 27 a - b   ) as well as markers of regulatory T cells, Foxp3 and Gpr83 (adj p&lt;3.4e-23 for Foxp3; adj p&lt;4.2e-33 and 9.0e-31 for the two Gpr83 probesets;  FIG. 27 c - d   ). Copaxone® downregulated pro-inflammatory cytokines, such as 1112a (adjusted p&lt;8.3e-31;  FIG. 27 e   ). Consistently similar effects were observed for both immunization conditions (p values given above correspond to Copaxone® immunization, and are within the same order of magnitude for immunization by Polimunol). 
       Copaxone®-Modulated Pathways 
       [0402]    After imposing a conservative fold change filter of |FC|≧2, 411 probesets are upregulated by Copaxone® relative to medium (in Copaxone-immunized mice), and these probesets enrich for 76 pathways. These pathways include relevant aspects of Copaxone®&#39;s mechanism of action such as the cytokine-cytokine receptor interaction pathway identified previously in the THP-1 study for Copaxone mechanism of action (as well as differences observed with Polimunol). Similarly, 485 downregulated probesets are detected, which enrich for 56 pathways. Both the upregulated and downregulated pathways are depicted in  FIG. 28 . The full list of pathways entiched among top probesets modulated by Copaxone® relative to medium is provided in Table 15. 
         [0000]    
       
         
               
             
               
               
               
               
               
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 15 
               
             
             
               
                   
               
               
                 Pathways enriched among top probesets modulated by Copaxone ® 
               
               
                 relative to medium in splenocytes from mice immunized with Copaxone ® 
               
               
                 (Pathways enriched among top upregulated probesets listed first 
               
               
                 followed by pathways enriched among top downregulated probesets). 
               
             
          
           
               
                 Categery 
                 Term 
                 Count 
                 Pvalue 
                 Fold Enrichment 
                 Benjamini 
               
               
                   
               
             
          
           
               
                 GOTERM_MF_ALL 
                 GO: 0005125-cytokine activity 
                 20 
                 4.24E−14 
                 9.93177388 
                 2.11E−11 
               
               
                 KEGG_PATHWAY 
                 mmu04060: Cytokine-cytokine receptor interaction 
                 29 
                 1.86E−13 
                 5.15544371 
                 2.36E−11 
               
               
                 GOTERM_CC_ALL 
                 GO: 0005576-extracellular region 
                 44 
                 2.62E−13 
                 3.56241762 
                 5.65E−11 
               
               
                 GOTERM_CC_ALL 
                 GO: 0005615-extracellular space 
                 26 
                 2.29E−12 
                 5.71896261 
                 2.47E−10 
               
               
                 GOTERM_CC_ALL 
                 GO: 0044421-extracellular region part 
                 29 
                 5.96E−12 
                 4.84008694 
                 4.29E−10 
               
               
                 GOTERM_BP_ALL 
                 GO: 0006955-immune response 
                 34 
                 1.04E−11 
                 3.99299275 
                 1.66E−08 
               
               
                 KEGG_PATHWAY 
                 mmu04630: lak-STAT signaling pathway 
                 22 
                 2.63E−10 
                 5.24077519 
                 1.67E−08 
               
               
                 GOTERM_BP_ALL 
                 GO: 0002376-immune system process 
                 42 
                 2.48E−09 
                 2.76506571 
                 1.98E−06 
               
               
                 GOTERM_BP_ALL 
                 GO: 0016126-sterol biosynthetic process 
                 10 
                 6.57E−09 
                 15.1694577 
                 3.49E−06 
               
               
                 GOTERM_CC_ALL 
                 GO: 0009897-external side of plasma membrane 
                 17 
                 3.35E−07 
                 4.86392974 
                 1.81E−05 
               
               
                 GOTERM_BP_ALL 
                 GO: 0008299-isoprenoid biosynthetic process 
                 8 
                 5.51E−08 
                 19.4169059 
                 2.20E−05 
               
               
                 GOTERM_BP_ALL 
                 GO: 0016125-sterol metabolic process 
                 12 
                 8.93E−08 
                 8.56628202 
                 2.85E−05 
               
               
                 GOTERM_CC_ALL 
                 GO: 0009986-cell surface 
                 19 
                 9.95E−07 
                 4.01671583 
                 4.30E−05 
               
               
                 GOTERM_BP_ALL 
                 GO: 0006694-steroid biosynthetic process 
                 11 
                 1.64E−07 
                 9.31334149 
                 4.35E−05 
               
               
                 GOTERM_BP_ALL 
                 GO: 0006695-cholesterol biosynthetic process 
                 8 
                 3.93E−07 
                 15.3291362 
                 7.83E−05 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050896-response to stimulus 
                 65 
                 3.63E−07 
                 1.84733443 
                 8.26E−05 
               
               
                 KEGG_PATHWAY 
                 mmu00900: Terpenoid backbone biosynthesis 
                 7 
                 6.27E−06 
                 12.8270722 
                 0.00026558 
               
               
                 KEGG_PATHWAY 
                 mmu00100: Steroid biosynthesis 
                 7 
                 1.06E−05 
                 11.9108527 
                 0.00033672 
               
               
                 GOTERM_BP_ALL 
                 GO: 0008202-steroid metabolic process 
                 13 
                 2.89E−06 
                 5.56808331 
                 0.00035349 
               
               
                 GOTERM_BP_ALL 
                 GO: 0008203-cholesterol metabolic process 
                 10 
                 2.70E−06 
                 8.09037746 
                 0.00035891 
               
               
                 GOTERM_BP_ALL 
                 GO: 0008284-positive regulation of cell proliferation 
                 18 
                 2.13E−06 
                 3.99585716 
                 0.00037779 
               
               
                 GOTERM_BP_ALL 
                 GO: 0006720-isoprenoid metabolic process 
                 8 
                 2.40E−06 
                 12.1355662 
                 0.00038277 
               
               
                 GOTERM_BP_ALL 
                 GO: 0033138-positive regulation of peptidyl-serine phospherylation 
                 5 
                 2.66E−06 
                 36.4066986 
                 0.00038457 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050730-regulation of peptidyl-tyrosine phosphorylation 
                 9 
                 3.40E−06 
                 9.36172249 
                 0.00038657 
               
               
                 GOTERM_MF_ALL 
                 GO: 0005102-receptor binding 
                 24 
                 2.03E−06 
                 3.13177103 
                 0.00050318 
               
               
                 GOTERM_BP_ALL 
                 GO: 0042325-regulation of phosphorylation 
                 19 
                 6.54E−06 
                 3.51130595 
                 0.00069403 
               
               
                 GOTERM_BP_ALL 
                 GO: 0001932-regulation of protein amino acid phosphorylation 
                 12 
                 1.11E−05 
                 5.39358497 
                 0.00110231 
               
               
                 GOTERM_BP_ALL 
                 GO: 0051174-regulation of phosphorus metabolic process 
                 19 
                 1.22E−05 
                 3.35789938 
                 0.00114199 
               
               
                 GOTERM_BP_ALL 
                 GO: 0019220-regulation of phosphate metabolic process 
                 19 
                 1.22E−05 
                 3.35789938 
                 0.00114199 
               
               
                 GOTERM_BP_ALL 
                 GO: 0008610-lipid biosynthetic process 
                 18 
                 2.07E−05 
                 3.3779411 
                 0.00173185 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050731-positive regulation of peptidyl-tyresine phosphorylation 
                 7 
                 2.01E−05 
                 11.5839495 
                 0.00177599 
               
               
                 GOTERM_BP_ALL 
                 GO: 0042127-regulation of cell proliferation 
                 24 
                 2.57E−05 
                 2.68024775 
                 0.00204526 
               
               
                 GOTERM_BP_ALL 
                 GO: 0001934-positive regulation of protein amino acid 
                 8 
                 2.96E−05 
                 8.56628202 
                 0.00208413 
               
               
                   
                 phosphorylation 
                   
                   
                   
                   
               
               
                 GOTERM_BP_ALL 
                 GO: 0010740-positive regulation of protein kinase cascade 
                 10 
                 2.75E−05 
                 6.17062688 
                 0.00208529 
               
               
                 GOTERM_BP_ALL 
                 GO: 0010627-regulation of protein kinase cascade 
                 13 
                 2.92E−05 
                 4.46497247 
                 0.00210456 
               
               
                 GOTERM_BP_ALL 
                 GO: 0033135-regulation of peptidyl-serine phosphorylation 
                 5 
                 3.48E−05 
                 22.7541866 
                 0.00231024 
               
               
                 GOTERM_BP_ALL 
                 GO: 0042327-positive regulation of phosphorylation 
                 8 
                 4.38E−05 
                 8.09037746 
                 0.00279017 
               
               
                 GOTERM_BP_ALL 
                 GO: 0045937-positive regulation of phosphate metabolic process 
                 8 
                 5.28E−05 
                 7.87171861 
                 0.00323223 
               
               
                 GOTERM_BP_ALL 
                 GO: 0010562-positive regulation of phosphorus metabolic process 
                 8 
                 5.28E−05 
                 7.87171861 
                 0.00323223 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048522-positive regulation of cellular process 
                 41 
                 0.00014045 
                 1.83826926 
                 0.00825294 
               
               
                 GOTERM_BP_ALL 
                 GO: 0006952-defense response 
                 18 
                 0.0001494 
                 2.88687478 
                 0.00846421 
               
               
                 GOTERM_BP_ALL 
                 GO: 0006629-lipid metabolic process 
                 26 
                 0.00019818 
                 2.24306674 
                 0.01046917 
               
               
                 GOTERM_BP_ALL 
                 GO: 0006066-alcohol metabolic process 
                 18 
                 0.00019444 
                 2.82465765 
                 0.01062493 
               
               
                 GOTERM_BP_ALL 
                 GO: 0051251-positive regulation of lymphocyte activation 
                 10 
                 0.00037281 
                 4.43984129 
                 0.01839122 
               
               
                 GOTERM_BP_ALL 
                 GO: 0031399-regulation of protein modification process 
                 12 
                 0.00036131 
                 3.70237613 
                 0.01839468 
               
               
                 GOTERM_BP_ALL 
                 GO: 0008219-cell death 
                 24 
                 0.00038581 
                 2.24041222 
                 0.01845504 
               
               
                 GOTERM_BP_ALL 
                 GO: 0006915-apoptosis 
                 23 
                 0.00041493 
                 2.28161871 
                 0.01925699 
               
               
                 GOTERM_BP_ALL 
                 GO: 0016265-death 
                 24 
                 0.00049622 
                 2.20090873 
                 0.02006939 
               
               
                 GOTERM_BP_ALL 
                 GO: 0002696-positive regulation of leukocyte activation 
                 10 
                 0.00044678 
                 4.33413078 
                 0.02013394 
               
               
                 GOTERM_BP_ALL 
                 GO: 0012501-programmed cell death 
                 23 
                 0.00046402 
                 2.2631191 
                 0.02032837 
               
               
                 GOTERM_BP_ALL 
                 GO: 0002694-regulation of leukocyte activation 
                 12 
                 0.0005166 
                 3.55187303 
                 0.0203686 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050867-positive regulation of cell activation 
                 10 
                 0.00053242 
                 4.23333704 
                 0.02047943 
               
               
                 GOTERM_BP_ALL 
                 GO: 0043410-positive regulation of MAPKKK cascade 
                 6 
                 0.00049453 
                 8.73760766 
                 0.02052261 
               
               
                 GOTERM_BP_ALL 
                 GO: 0009967-positive regulation of signal transduction 
                 11 
                 0.00048296 
                 3.88809402 
                 0.02058357 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050865-regulation of cell activation 
                 12 
                 0.00059269 
                 3.49504306 
                 0.02223545 
               
               
                 GOTERM_BP_ALL 
                 GO: 0031401-positive regulation of protein modification process 
                 8 
                 0.0006867 
                 5.29551979 
                 0.02512736 
               
               
                 GOTERM_BP_ALL 
                 GO: 0010647-positive regulation of cell communication 
                 11 
                 0.0007042 
                 3.70808967 
                 0.02518163 
               
               
                 GOTERM_BP_ALL 
                 GO: 0051048-negative regulation of secretion 
                 5 
                 0.00076246 
                 11.3770933 
                 0.02664025 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048568-embryonic organ development 
                 10 
                 0.00080674 
                 4.00073611 
                 0.02756213 
               
               
                 GOTERM_BP_ALL 
                 GO: 0010604-positive regulation of macromolecule metabolic process 
                 23 
                 0.00085004 
                 2.1637056 
                 0.02841182 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048518-positive regulation of biological process 
                 42 
                 0.0009007 
                 1.66566595 
                 0.0288702 
               
               
                 GOTERM_MF_ALL 
                 GO: 0016705-oxidoreductase activity, acting on paired donors, 
                 9 
                 0.00029543 
                 5.1901528 
                 0.02894292 
               
               
                   
                 with incorporation 
                   
                   
                   
                   
               
               
                 GOTERM_BP_ALL 
                 GO: 0044255-cellular lipid metabolic process 
                 20 
                 0.00088925 
                 2.32630662 
                 0.02909335 
               
               
                 GOTERM_MF_ALL 
                 GO: 0042379-chemokine receptor binding 
                 6 
                 0.00035759 
                 9.32723112 
                 0.02919116 
               
               
                 GOTERM_MF_ALL 
                 GO: 0004888-transmembrane receptor activity 
                 18 
                 0.00042544 
                 2.64847303 
                 0.02976082 
               
               
                 GOTERM_MF_ALL 
                 GO: 0019955-cytokine binding 
                 9 
                 0.00018429 
                 5.54809437 
                 0.0300713 
               
               
                 GOTERM_BP_ALL 
                 GO: 0046888-negative regulation of hormone secretion 
                 4 
                 0.0010187 
                 18.2033493 
                 0.03195084 
               
               
                 GOTERM_MF_ALL 
                 GO: 0008009-chemokine activity 
                 6 
                 0.00028629 
                 9.75119617 
                 0.03495115 
               
               
                 GOTERM_BP_ALL 
                 GO: 0042180-cellular ketone metabolic process 
                 20 
                 0.00120964 
                 2.26833013 
                 0.0364004 
               
               
                 GOTERM_BP_ALL 
                 GO: 0016053-organic acid biosynthetic process 
                 10 
                 0.00118661 
                 3.79236443 
                 0.03640669 
               
               
                 GOTERM_BP_ALL 
                 GO: 0046394-carboxylic acid biosynthetic process 
                 10 
                 0.00118661 
                 3.79236443 
                 0.03640669 
               
               
                 GOTERM_BP_ALL 
                 GO: 0051249-regulation of lymphocyte activation 
                 11 
                 0.00131104 
                 3.422852 
                 0.0386639 
               
               
                 KEGG_PATHWAY 
                 mmu05320: Autoimmune thyroid disease 
                 7 
                 0.00172331 
                 5.21099806 
                 0.04286406 
               
               
                 GOTERM_BP_ALL 
                 GO: 0009611-response to wounding 
                 14 
                 0.00154486 
                 2.77007489 
                 0.04458422 
               
               
                 GOTERM_BP_ALL 
                 GO: 0006954-inflammatory response 
                 11 
                 0.00158927 
                 3.3372807 
                 0.04502272 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050864-regulation of B cell activation 
                 7 
                 0.00163582 
                 5.42227425 
                 0.04550354 
               
               
                 GOTERM_CC_ALL 
                 GO: 0044425-membrane part 
                 167 
                 3.13E−15 
                 1.63662801 
                 7.90E−13 
               
               
                 GOTERM_CC_ALL 
                 GO: 0031224-intrinsic to membrane 
                 140 
                 8.73E−15 
                 1.77744709 
                 1.11E−12 
               
               
                 GOTERM_CC_ALL 
                 GO: 0016021-integral to membrane 
                 135 
                 3.09E−14 
                 1.78531887 
                 2.61E−12 
               
               
                 GOTERM_MF_ALL 
                 GO: 0004872-receptor activity 
                 59 
                 6.67E−15 
                 3.07839222 
                 3.10E−12 
               
               
                 GOTERM_CC_ALL 
                 GO: 0016020-membrane 
                 172 
                 3.65E−12 
                 1.50486701 
                 2.32E−10 
               
               
                 GOTERM_MF_ALL 
                 GO: 0004871-signal transducer activity 
                 63 
                 1.62E−12 
                 2.59629647 
                 3.77E−10 
               
               
                 GOTERM_MF_ALL 
                 GO: 0060089-molecular transducer activity 
                 63 
                 1.62E−12 
                 2.59629647 
                 3.77E−10 
               
               
                 GOTERM_BP_ALL 
                 GO: 0006955-immune response 
                 40 
                 6.54E−13 
                 3.77617866 
                 1.06E−09 
               
               
                 GOTERM_MF_ALL 
                 GO: 0004888-transmembrane receptor activity 
                 33 
                 3.17E−11 
                 3.96796318 
                 4.91E−09 
               
               
                 GOTERM_BP_ALL 
                 GO: 0002376-immune system process 
                 53 
                 7.56E−12 
                 2.80481986 
                 6.14E−09 
               
               
                 GOTERM_CC_ALL 
                 GO: 0009986-cell surface 
                 27 
                 2.11E−10 
                 4.47916667 
                 1.07E−08 
               
               
                 GOTERM_CC_ALL 
                 GO: 0005886-plasma membrane 
                 83 
                 1.60E−09 
                 1.91980807 
                 6.79E−08 
               
               
                 GOTERM_CC_ALL 
                 GO: 0005576-extracellular region 
                 42 
                 1.08E−08 
                 2.66843972 
                 3.93E−07 
               
               
                 GOTERM_MF_ALL 
                 GO: 0030246-carbohydrate binding 
                 21 
                 1.71E−08 
                 4.64841968 
                 1.99E−06 
               
               
                 GOTERM_CC_ALL 
                 GO: 0044421-extracellular region part 
                 26 
                 1.42E−07 
                 3.40521443 
                 4.51E−06 
               
               
                 KEGG_PATHWAY 
                 mmu04640: Hematopoietic cell lineage 
                 14 
                 2.50E−07 
                 5.97693804 
                 2.75E−05 
               
               
                 GOTERM_BP_ALL 
                 GO: 0009605-response to external stimulus 
                 33 
                 7.98E−08 
                 2.90017325 
                 4.32E−05 
               
               
                 GOTERM_CC_ALL 
                 GO: 0009897-external side of plasma membrane 
                 18 
                 1.84E−06 
                 4.04135338 
                 5.20E−05 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050896-response to stimulus 
                 77 
                 2.55E−07 
                 1.75912148 
                 8.30E−05 
               
               
                 GOTERM_BP_ALL 
                 GO: 0007166-cell surface receptor linked signal transduction 
                 43 
                 2.53E−07 
                 2.3390549 
                 0.00010269 
               
               
                 GOTERM_BP_ALL 
                 GO: 0009611-response to wounding 
                 22 
                 9.96E−07 
                 3.49912207 
                 0.00026984 
               
               
                 GOTERM_BP_ALL 
                 GO: 0002682-regulation of immune system process 
                 25 
                 1.60E−06 
                 3.07409502 
                 0.00037039 
               
               
                 GOTERM_CC_ALL 
                 GO: 0005615-extracellular space 
                 19 
                 1.75E−05 
                 3.279544 
                 0.00044365 
               
               
                 GOTERM_BP_ALL 
                 GO: 0002684-positive regulation of immune system process 
                 19 
                 4.74E−06 
                 3.58736973 
                 0.00096165 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048584-positive regulation of response to stimulus 
                 17 
                 5.63E−06 
                 3.91741369 
                 0.0010166 
               
               
                 GOTERM_BP_ALL 
                 GO: 0006952-defense response 
                 23 
                 8.45E−06 
                 2.96521518 
                 0.00137227 
               
               
                 GOTERM_MF_ALL 
                 GO: 0005529-sugar binding 
                 13 
                 1.92E−05 
                 4.6322231 
                 0.00178054 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050778-positive regulation of immune response 
                 14 
                 1.56E−05 
                 4.3586743 
                 0.00230833 
               
               
                 GOTERM_CC_ALL 
                 GO: 0044459-plasma membrane part 
                 46 
                 0.00011625 
                 1.79088802 
                 0.00268093 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050776-regulation of immune response 
                 16 
                 5.03E−05 
                 3.46849003 
                 0.00679349 
               
               
                 GOTERM_MF_ALL 
                 GO: 0005539-glycosaminoglycan binding 
                 8 
                 0.00012123 
                 6.87497365 
                 0.00935188 
               
               
                 GOTERM_BP_ALL 
                 GO: 0007155-cell adhesion 
                 20 
                 0.00010998 
                 2.74792344 
                 0.0136546 
               
               
                 GOTERM_BP_ALL 
                 GO: 0022610-biological adhesion 
                 20 
                 0.00010998 
                 2.74792344 
                 0.0136546 
               
               
                 GOTERM_BP_ALL 
                 GO: 0007626-locomotory behavior 
                 14 
                 0.0001342 
                 3.56274248 
                 0.01545668 
               
               
                 GOTERM_MF_ALL 
                 GO: 0008201-heparin binding 
                 7 
                 0.00024088 
                 7.57520244 
                 0.01587561 
               
               
                 GOTERM_MF_ALL 
                 GO: 0001871-pattern binding 
                 8 
                 0.00029954 
                 5.99356677 
                 0.01726258 
               
               
                 GOTERM_MF_ALL 
                 GO: 0030247-polysaccharide binding 
                 8 
                 0.00029954 
                 5.99356677 
                 0.01726258 
               
               
                 GOTERM_BP_ALL 
                 GO: 0006909-phagocytosis 
                 8 
                 0.00017473 
                 6.5034188 
                 0.01759075 
               
               
                 GOTERM_BP_ALL 
                 GO: 0032501-multicellular organismal process 
                 77 
                 0.00017032 
                 1.47960251 
                 0.01828376 
               
               
                 GOTERM_BP_ALL 
                 GO: 0006954-inflammatory response 
                 14 
                 0.00020677 
                 3.41429487 
                 0.01957233 
               
               
                 GOTERM_BP_ALL 
                 GO: 0042330-taxis 
                 10 
                 0.00022296 
                 4.72022333 
                 0.01992884 
               
               
                 GOTERM_BP_ALL 
                 GO: 0006935-chemotaxis 
                 10 
                 0.00022296 
                 4.72022333 
                 0.01992884 
               
               
                 GOTERM_CC_ALL 
                 GO: 0005578-proteinaceous extracellular matrix 
                 9 
                 0.00121761 
                 4.19921875 
                 0.0254587 
               
               
                 GOTERM_BP_ALL 
                 GO: 0007186-G-protein coupled receptor protein signaling pathway 
                 17 
                 0.00035255 
                 2.79500864 
                 0.02970748 
               
               
                 GOTERM_MF_ALL 
                 GO: 0001664-G-protein-coupled receptor binding 
                 7 
                 0.00063894 
                 6.39157706 
                 0.03248313 
               
               
                 GOTERM_MF_ALL 
                 GO: 0008009-chemokine activity 
                 6 
                 0.00072678 
                 7.96871945 
                 0.03324267 
               
               
                 GOTERM_BP_ALL 
                 GO: 0008037-cell recognition 
                 6 
                 0.00044777 
                 8.77961539 
                 0.03406274 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050900-leukocyte migration 
                 7 
                 0.00043774 
                 6.82858974 
                 0.03494842 
               
               
                 GOTERM_MF_ALL 
                 GO: 0042379-chemokine receptor binding 
                 6 
                 0.00090307 
                 7.62225339 
                 0.03747238 
               
               
                 GOTERM_MF_ALL 
                 GO: 0004930-G-protein coupled receptor activity 
                 12 
                 0.0010892 
                 3.24651533 
                 0.03823098 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048583-regulation of response to stimulus 
                 19 
                 0.00053982 
                 2.50469508 
                 0.03909905 
               
               
                 GOTERM_BP_ALL 
                 GO: 0060326-cell chemotaxis 
                 6 
                 0.00057152 
                 8.36153846 
                 0.03958565 
               
               
                 GOTERM_BP_ALL 
                 GO: 0030595-leukocyte chemotaxis 
                 6 
                 0.00057152 
                 8.36153846 
                 0.03958565 
               
               
                 GOTERM_MF_ALL 
                 GO: 0005102-receptor binding 
                 21 
                 0.00105337 
                 2.23938466 
                 0.04001704 
               
               
                 GOTERM_CC_ALL 
                 GO: 0031012-extracellular matrix 
                 9 
                 0.00218595 
                 3.83928571 
                 0.04185565 
               
               
                 GOTERM_BP_ALL 
                 GO: 0007165-signal transduction 
                 51 
                 0.00074467 
                 1.58780278 
                 0.04918842 
               
               
                   
               
             
          
         
       
     
       Copaxone® MoA Discussion 
       [0403]    More than two thirds of the probesets expressed in the spleen were significantly modulated by Copaxone® treatment, and the top modulated probesets in either direction were enriched for many relevant pathways, including immune response and cytokine-cytokine receptor interaction pathways. Key anti-inflammatory cytokines, such as 1110 and 114, and regulatory T cell markers, such as Foxp3 and Gpr83, are upregulated by Copaxone®, while pro-inflammatory cytokines, such as 1112a, is downregulated by Copaxone® treatment in this model system, consistent with induction of a Th1 to Th2 shift. Thus, these studies help to illustrate the complexity of Copaxone&#39;s mechanism of action (impacting thousands of genes in over 100 different pathways), and provide validation of the experimental system 
       Polimunol and Copaxone Comparison: Differentially Expressed Genes, Under Copaxone Immunization 
       [0404]    When splenocytes from Copaxone-immunized mice were activated with Polimunol and compared to activation by Copaxone® (as reported in the prior section), controlling for mannitol control, 223 probesets were found to be differentially expressed (208 were upregulated, 15 were downregulated). The top 25 upregulated probesets by Polimunol versus Copaxone are reported in Table 16, and include many interferon-induced genes as will be further discussed in the pathway enrichment section below. The 15 downregulated probesets by Polimunol versus Copaxone® are reported in Table 17. 
       Polimunol and Copaxone® Comparison: Differentially Expressed Genes, Under Polimunol Immunization 
       [0405]    When splenocytes from Polimunol-immunized mice were activated with Copaxone® versus Polimunol, 431 probesets were found to be differentially expressed when both were corrected for medium (301 were upregulated, 130 were downregulated). The top 25 upregulated probesets by Polimunol versus Copaxone® are reported in Table 18 and consistently with the reciprocal study design (prior paragraph) include many interferon induced genes, and the top 25 downregulated probesets by Polimunol versus Copaxone® are reported in Table 19. 
         [0000]    
       
         
               
             
               
               
               
               
               
             
           
               
                 TABLE 16 
               
             
             
               
                   
               
               
                 Top 25 probesets upregulated by Polimunol versus Copaxone ® 
               
               
                 In splenocytes from Copaxone ®-immunized mice 
               
             
          
           
               
                 Probeset 
                 Gene 
                 raw.FC 
                 P.Value 
                 adj.P.Val. 
               
               
                   
               
               
                 1421551_s_at 
                 Ifi202b 
                 1.48 
                 6.69E−15 
                 3.02E−10 
               
               
                 1451905_a_at 
                 Mx1 
                 1.75 
                 2.21E−14 
                 4.98E−10 
               
               
                 1421998_at 
                 Tor3a 
                 1.29 
                 9.33E−14 
                 1.40E−09 
               
               
                 1457666_s_at 
                 Ifi202b /// 
                 1.49 
                 1.25E−13 
                 1.41E−09 
               
               
                   
                 LOC100044068 
                   
                   
                   
               
               
                 1424339_at 
                 Oasl1 
                 1.46 
                 2.05E−13 
                 1.69E−09 
               
               
                 1418293_at 
                 Ifit2 
                 1.38 
                 2.24E−13 
                 1.69E−09 
               
               
                 1423555_a_at 
                 Ifi44 
                 1.62 
                 2.85E−13 
                 1.84E−09 
               
               
                 1425917_at 
                 Ifi44l 
                 1.63 
                 4.06E−12 
                 2.29E−08 
               
               
                 1421596_s_at 
                 Ifi44l 
                 1.63 
                 1.40E−11 
                 7.03E−08 
               
               
                 1456164_at 
                 AW011738 
                 1.20 
                 2.32E−11 
                 9.03E−08 
               
               
                 1450454_at 
                 Tor3a 
                 1.25 
                 2.40E−11 
                 9.03E−08 
               
               
                 1449455_at 
                 Hck 
                 1.16 
                 4.06E−11 
                 1.33E−07 
               
               
                 1448775_at 
                 Gm16340 /// Ifi203 /// 
                 1.21 
                 4.16E−11 
                 1.33E−07 
               
               
                   
                 LOC100862473 
                   
                   
                   
               
               
                 1438868_at 
                 Phf11d 
                 1.25 
                 4.42E−11 
                 1.33E−07 
               
               
                 1428660_s_at 
                 Tor3a 
                 1.25 
                 5.25E−11 
                 1.41E−07 
               
               
                 1434401_at 
                 Zcchc2 
                 1.16 
                 5.31E−11 
                 1.41E−07 
               
               
                 1418191_at 
                 Usp18 
                 1.39 
                 1.10E−10 
                 2.71E−07 
               
               
                 1450027_at 
                 Sdc3 
                 1.25 
                 1.14E−10 
                 2.71E−07 
               
               
                 1435331_at 
                 Pyhin1 
                 1.19 
                 2.12E−10 
                 4.79E−07 
               
               
                 1436120_at 
                 Setdb2 
                 1.16 
                 2.43E−10 
                 5.21E−07 
               
               
                 1451330_a_at 
                 Inpp5b 
                 1.12 
                 3.00E−10 
                 6.14E−07 
               
               
                 1424921_at 
                 Bst2 
                 1.23 
                 3.99E−10 
                 7.83E−07 
               
               
                 1419603_at 
                 Ifi204 
                 1.44 
                 5.16E−10 
                 9.70E−07 
               
               
                 1438037_at 
                 Herc6 
                 1.27 
                 6.06E−10 
                 1.09E−06 
               
               
                 1419026_at 
                 Daxx 
                 1.21 
                 6.74E−10 
                 1.7E−06 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE 17 
               
             
             
               
                   
               
               
                 15 probesets downregulated by Polimunol versus Copaxone ® In 
               
               
                 splenocytes from Copaxone ®-immunized mice 
               
             
          
           
               
                 Probeset 
                 Gene 
                 raw.FC 
                 P.Value 
                 adj.P.Val. 
               
               
                   
               
             
          
           
               
                 1454757_s_at 
                 Ifi27l1 
                 −1.15 
                 1.92E−08 
                 1.57E−05 
               
               
                 1415837_at 
                 Klk1 
                 −1.41 
                 4.55E−08 
                 3.16E−05 
               
               
                 1452956_a_at 
                 Ifi27l1 
                 −1.14 
                 1.80E−07 
                 9.56E−05 
               
               
                 1448107_x_at 
                 Klk1 
                 −1.34 
                 2.21E−07 
                 0.000114521 
               
               
                 1439771_s_at 
                 D13ERTD608E 
                 −1.25 
                 2.71E−07 
                 0.00013591 
               
               
                 1415823_at 
                 Scd2 
                 −1.35 
                 3.68E−06 
                 0.001275671 
               
               
                 1442544_at 
                 Ighm 
                 −1.17 
                 5.89E−06 
                 0.001916738 
               
               
                 1415824_at 
                 Scd2 
                 −1.31 
                 2.36E−05 
                 0.006376176 
               
               
                 1415822_at 
                 Scd2 
                 −1.28 
                 3.43E−05 
                 0.008489827 
               
               
                 1429100_at 
                 Ccdc71l 
                 −1.08 
                 3.68E−05 
                 0.008965532 
               
               
                 1427756_x_at 
                 Ighm 
                 −1.17 
                 4.61E−05 
                 0.010874062 
               
               
                 1449325_at 
                 Fads2 
                 −1.16 
                 0.000104782 
                 0.022291363 
               
               
                 1416188_at 
                 Gm2a 
                 −1.08 
                 0.000109828 
                 0.023255206 
               
               
                 1424567_at 
                 Tspan2 
                 −1.13 
                 0.00016899 
                 0.033873925 
               
               
                 1436131_at 
                 Siglech 
                 −1.12 
                 0.000216398 
                 0.042416254 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
               
               
             
           
               
                 TABLE 18 
               
             
             
               
                   
               
               
                 Top 25 probesets upregulated by Polimunol versus Copaxone ® in 
               
               
                 splenocytes from Polimunol-immunized mice 
               
             
          
           
               
                 Probeset 
                 Gene 
                 raw.FC 
                 P.Value 
                 adj.P.Val. 
               
               
                   
               
               
                 1434401_at 
                 Zcchc2 
                 1.17 
                 6.74E−14 
                 1.96E−09 
               
               
                 1417932_at 
                 Il18 
                 1.26 
                 8.67E−14 
                 1.96E−09 
               
               
                 1457035_at 
                 AI607873 
                 1.43 
                 1.41E−12 
                 2.10E−08 
               
               
                 1421551_s_at 
                 Ifi202b 
                 1.43 
                 1.86E−12 
                 2.10E−08 
               
               
                 1419599_s_at 
                 Ms4a6d 
                 1.38 
                 5.58E−12 
                 5.04E−08 
               
               
                 1456164_at 
                 AW011738 
                 1.21 
                 1.21E−11 
                 9.11E−08 
               
               
                 1457666_s_at 
                 Ifi202b /// 
                 1.44 
                 5.60E−11 
                 2.73E−07 
               
               
                   
                 LOC100044068 
                   
                   
                   
               
               
                 1449591_at 
                 Casp4 
                 1.11 
                 6.06E−11 
                 2.73E−07 
               
               
                 1440865_at 
                 Ifitm6 
                 1.23 
                 7.78E−11 
                 3.19E−07 
               
               
                 1438004_at 
                 Papd7 
                 1.19 
                 9.92E−11 
                 3.44E−07 
               
               
                 1426721_s_at 
                 Tiparp 
                 1.12 
                 1.80E−10 
                 5.81E−07 
               
               
                 1426716_at 
                 Tdrd7 
                 1.21 
                 2.85E−10 
                 8.56E−07 
               
               
                 1419598_at 
                 Ms4a6d 
                 1.33 
                 7.99E−10 
                 2.17E−06 
               
               
                 1420796_at 
                 Ahrr 
                 1.47 
                 1.38E−09 
                 3.45E−06 
               
               
                 1436058_at 
                 Rsad2 
                 1.52 
                 2.07E−09 
                 4.67E−06 
               
               
                 1421008_at 
                 Rsad2 
                 1.40 
                 2.22E−09 
                 4.77E−06 
               
               
                 1421009_at 
                 Rsad2 
                 1.53 
                 2.56E−09 
                 5.07E−06 
               
               
                 1418293_at 
                 Ifit2 
                 1.42 
                 2.58E−09 
                 5.07E−06 
               
               
                 1427102_at 
                 Slfn4 
                 1.42 
                 2.86E−09 
                 5.38E−06 
               
               
                 1453939_x_at 
                 Gm9706 
                 1.28 
                 3.33E−09 
                 6.02E−06 
               
               
                 1427747_a_at 
                 Lcn2 
                 1.21 
                 3.54E−09 
                 6.14E−06 
               
               
                 1447851_x_at 
                 Atp10a 
                 1.16 
                 4.58E−09 
                 7.37E−06 
               
               
                 1450322_s_at 
                 Slfh3 /// Slfn4 
                 1.38 
                 5.25E−09 
                 8.17E−06 
               
               
                 1438148_at 
                 Cxcl3 
                 1.68 
                 6.34E−09 
                 9.54E−06 
               
               
                 1451905_a_at 
                 Mx1 
                 1.79 
                 1.09E−08 
                 1.54E−05 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE 19 
               
             
             
               
                   
               
               
                 Top 25 probesets downregulated by Polimunol versus Copaxone ® in 
               
               
                 splenocytes from Polimunol-immunizad mice 
               
             
          
           
               
                 Probeset 
                 Gene 
                 raw.FC 
                 P.Value 
                 adj.P.Val. 
               
               
                   
               
             
          
           
               
                 1436839_at 
                 Ccdc71l 
                 −1.14 
                 3.56E−11 
                 2.11E−07 
               
               
                 1451461_a_at 
                 Aldoc 
                 −1.60 
                 3.75E−11 
                 2.11E−07 
               
               
                 1454757_s_at 
                 Ifi27l1 
                 −1.15 
                 9.61E−11 
                 3.44E−07 
               
               
                 1442544_at 
                 Ighm 
                 −1.29 
                 8.19E−10 
                 2.17E−06 
               
               
                 1452956_a_at 
                 Ifi27l1 
                 −1.13 
                 1.68E−09 
                 3.99E−06 
               
               
                 1417679_at 
                 Gfi1 
                 −1.23 
                 4.10E−09 
                 6.85E−06 
               
               
                 1417864_at 
                 Pgk1 
                 −1.19 
                 8.66E−09 
                 1.26E−05 
               
               
                 1429100_at 
                 Ccdc71l 
                 −1.12 
                 1.45E−08 
                 1.99E−05 
               
               
                 1435086_s_at 
                 Klhdc2 
                 −1.13 
                 4.23E−08 
                 4.33E−05 
               
               
                 1451385_at 
                 Fam162a 
                 −1.17 
                 1.15E−07 
                 0.000102062 
               
               
                 1417034_at 
                 Trappc6a 
                 −1.18 
                 1.33E−07 
                 0.000111102 
               
               
                 1435659_a_at 
                 Tpi1 
                 −1.37 
                 1.69E−07 
                 0.000128996 
               
               
                 1415995_at 
                 Casp6 
                 −1.13 
                 2.32E−07 
                 0.000164607 
               
               
                 1450081_x_at 
                 Gpi1 
                 −1.13 
                 3.06E−07 
                 0.000206058 
               
               
                 1434814_x_at 
                 Gpi1 
                 −1.11 
                 4.41E−07 
                 0.000287936 
               
               
                 1418709_at 
                 Cox7a1 
                 −1.31 
                 4.64E−07 
                 0.000298801 
               
               
                 1417772_at 
                 Grhpr 
                 −1.23 
                 4.84E−07 
                 0.000307264 
               
               
                 1439435_x_at 
                 Pgk1 
                 −1.16 
                 5.64E−07 
                 0.000334169 
               
               
                 1438640_x_at 
                 Pgk1 
                 −1.15 
                 7.54E−07 
                 0.00040969 
               
               
                 1417308_at 
                 Pkm 
                 −1.14 
                 1.00E−06 
                 0.000518315 
               
               
                 1415918_a_at 
                 Tpi1 
                 −1.31 
                 1.08E−06 
                 0.00055306 
               
               
                 1424714_at 
                 Aldoc 
                 −1.32 
                 1.23E−06 
                 0.000599143 
               
               
                 1418649_at 
                 Egln3 
                 −1.27 
                 1.29E−06 
                 0.000610123 
               
               
                 1452927_x_at 
                 Tpi1 
                 −1.29 
                 1.34E−06 
                 0.000631391 
               
               
                 1457587_at 
                 Kcnq5 
                 −1.14 
                 1.86E−06 
                 0.000789811 
               
               
                   
               
             
          
         
       
     
         [0406]    It is important to note that for either immunization (Copaxone® or Polimunol), I118 and its receptor I118r1 are downregulated (and inhibitor I118 bp is upregulated) by both of the activation treatments, Copaxone® and Polimunol. I118 is downregulated significantly less by Polimunol than by Copaxone® (differential expression FDR p&lt;9e-6 (FC 1.20) with Copaxone® immunization and FDR p&lt;2e-9 (FC 1.26) for Polimunol immunization). Downregulation of both I118 and I118r1 expression upon Copaxone® treatment was also reported in an earlier splenocyte study of similar design (Bakshi et al, 2013). Boxplots of I118 expression are shown in  FIG. 29 . 
         [0407]    The probesets significantly entiched among top probesets modulated by Copaxone® relative to medium is provided in Table 20. 
         [0000]    
       
         
               
             
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
             
           
               
                 TABLE 20 
               
             
             
               
                   
               
               
                 Top probesets significantly differentially expressed between Polimunol and Copaxone ® treatment 
               
               
                 (corrected for medium control) in splenocytes from Copaxone ®-immunized mice. 
               
             
          
           
               
                 Probeset 
                 Gene 
                 raw. FC 
                 AveExpr 
                 t 
                 P. Value 
                 adj. P. Val 
                 B 
               
               
                   
               
             
          
           
               
                 1421551_s_a 
                 Ifi202b 
                 1.47550912 
                 9.16666894 
                 10.5600946 
                 6.69E−15 
                 3.02E−10 
                 22.5317107 
               
               
                 1451905_a_a 
                 Mx1 
                 1.75432592 
                 8.47709648 
                 10.2249021 
                 2.21E−14 
                 4.98E−10 
                 21.4748998 
               
               
                 1421998_at 
                 Tor3a 
                 1.2928856 
                 9.17160227 
                 9.82507613 
                 9.33E−14 
                 1.40E−09 
                 20.1932231 
               
               
                 1457666_s_a 
                 Ifi202b /// L           
                 1.49450011 
                 8.60997589 
                 9.74469879 
                 1.25E−13 
                 1.41E−09 
                 19.9328881 
               
               
                 1424339_at 
                 Oasl1 
                 1.46319835 
                 9.8248556 
                 9.60829298 
                 2.05E−13 
                 1.69E−09 
                 19.489091 
               
               
                 1418293_at 
                 Ifit2 
                 1.38359824 
                 10.906172 
                 9.5837092 
                 2.24E−13 
                 1.69E−09 
                 19.4088447 
               
               
                 1423555_a_a 
                 Ifi44 
                 1.62258196 
                 9.94187992 
                 9.51838876 
                 2.85E−13 
                 1.84E−09 
                 19.1952407 
               
               
                 1425917_at 
                 Ifi44l 
                 1.6309207 
                 8.85125178 
                 8.79871072 
                 4.06E−12 
                 2.29E−08 
                 16.8068255 
               
               
                 1421596_s_a 
                 Ifi44l 
                 1.62779642 
                 8.55050842 
                 8.4667453 
                 1.40E−11 
                 7.03E−08 
                 15.6855236 
               
               
                 1456164_at 
                 AW011738 
                 1.19734234 
                 6.98570845 
                 8.33256611 
                 2.32E−11 
                 9.03E−08 
                 15.2292395 
               
               
                 1450454_at 
                 Tor3a 
                 1.25024933 
                 8.74969803 
                 8.32329605 
                 2.40E−11 
                 9.03E−08 
                 15.1976556 
               
               
                 1449455_at 
                 Hck 
                 1.1582816 
                 10.9515022 
                 8.18380999 
                 4.06E−11 
                 1.33E−07 
                 14.7215139 
               
               
                 1448775_at 
                 Gm16340 //           
                 1.20618615 
                 11.6014591 
                 8.1770987 
                 4.16E−11 
                 1.33E−07 
                 14.6985633 
               
               
                 1438868_at 
                 Phf11d 
                 1.2483759 
                 10.329053 
                 8.16092351 
                 4.42E−11 
                 1.33E−07 
                 14.6432337 
               
               
                 1428660_s_a 
                 Tor3a 
                 1.248966 
                 10.5033156 
                 8.11568562 
                 5.25E−11 
                 1.41E−07 
                 14.488379 
               
               
                 1434401_at 
                 Zcchc2 
                 1.15603797 
                 10.8249905 
                 8.1125305 
                 5.31E−11 
                 1.41E−07 
                 14.4775726 
               
               
                 1418191_at 
                 Usp18 
                 1.38861948 
                 11.5218281 
                 7.91969756 
                 1.10E−10 
                 2.71E−07 
                 13.8156858 
               
               
                 1450027_at 
                 Sdc3 
                 1.25031078 
                 10.4588938 
                 7.9099888 
                 1.14E−10 
                 2.71E−07 
                 13.7822905 
               
               
                 1435331_at 
                 Pyhin1 
                 1.19292098 
                 12.437413 
                 7.74536994 
                 2.12E−10 
                 4.79E−07 
                 13.2151145 
               
               
                 1436120_at 
                 Setdb2 
                 1.15959289 
                 10.4269299 
                 7.71019806 
                 2.43E−10 
                 5.21E−07 
                 13.0937189 
               
               
                 1451330_a_a 
                 Inpp5b 
                 1.12122817 
                 10.7773832 
                 7.65452165 
                 3.00E−10 
                 6.14E−07 
                 12.90141 
               
               
                 1424921_at 
                 Bst2 
                 1.22915197 
                 11.6875461 
                 7.57865485 
                 3.99E−10 
                 7.83E−07 
                 12.6390995 
               
               
                 1419603_at 
                 Ifi204 
                 1.43740773 
                 7.15143963 
                 7.51082104 
                 5.16E−10 
                 9.70E−07 
                 12.4043263 
               
               
                 1438037_at 
                 Herc6 
                 1.27135334 
                 10.4464057 
                 7.46845772 
                 6.06E−10 
                 1.09E−06 
                 12.2576026 
               
               
                 1419026_at 
                 Daxx 
                 1.20586588 
                 12.032791 
                 7.44071108 
                 6.74E−10 
                 1.17E−06 
                 12.1614627 
               
               
                 1451567_a_a 
                 Gm16340 //           
                 1.14843448 
                 12.2623403 
                 7.42376782 
                 7.18E−10 
                 1.20E−06 
                 12.1027407 
               
               
                 1426716_at 
                 Tdrd7 
                 1.17546145 
                 9.81553185 
                 7.38758714 
                 8.24E−10 
                 1.33E−06 
                 11.9773091 
               
               
                 1426774_at 
                 Parp12 
                 1.23323427 
                 10.568185 
                 7.32082974 
                 1.06E−09 
                 1.60E−06 
                 11.7457533 
               
               
                 1426276_at 
                 Ifih1 
                 1.25213306 
                 10.3259786 
                 7.3202472 
                 1.06E−09 
                 1.60E−06 
                 11.7437321 
               
               
                 1435665_at 
                 Trim30d 
                 1.25197418 
                 9.71194292 
                 7.26872528 
                 1.29E−09 
                 1.88E−06 
                 11.5649255 
               
               
                 1431591_s_a 
                 Gm9706 ///           
                 1.32351255 
                 11.382458 
                 7.17864536 
                 1.82E−09 
                 2.56E−06 
                 11.2521346 
               
               
                 1435330_at 
                 Pyhin1 
                 1.20956064 
                 9.18347439 
                 7.12657207 
                 2.22E−09 
                 3.03E−06 
                 11.0712364 
               
               
                 1438716_at 
                 Trim30d 
                 1.23305159 
                 7.93829998 
                 7.11825503 
                 2.29E−09 
                 3.03E−06 
                 11.0423392 
               
               
                 1421008_at 
                 Rsad2 
                 1.40087837 
                 7.80703835 
                 7.0280384 
                 3.22E−09 
                 4.15E−06 
                 10.7288224 
               
               
                 1421571_a_a 
                 Ly6c1 /// Ly6 
                 1.12684658 
                 13.613752 
                 6.99594752 
                 3.64E−09 
                 4.56E−06 
                 10.6172805 
               
               
                 1435792_at 
                 Csprs /// Gm 
                 1.187456 
                 9.75936346 
                 6.97563188 
                 3.93E−09 
                 4.76E−06 
                 10.5466635 
               
               
                 1423754_at 
                 Ifitm3 
                 1.19002363 
                 12.4964655 
                 6.96462013 
                 4.10E−09 
                 4.76E−06 
                 10.5083857 
               
               
                 1457035_at 
                 Al607873 
                 1.33928347 
                 5.46136565 
                 6.96314834 
                 4.12E−09 
                 4.76E−06 
                 10.5032697 
               
               
                 1453939_x_a 
                 Gm9706 
                 1.28772667 
                 8.70376747 
                 6.95300697 
                 4.28E−09 
                 4.83E−06 
                 10.468017 
               
               
                 1420671_x_a 
                 Ms4a4c 
                 1.11351765 
                 13.1959702 
                 6.9122537 
                 5.00E−09 
                 5.50E−06 
                 10.326351 
               
               
                 1426721_s_a 
                 Tiparp 
                 1.12038515 
                 10.8883102 
                 6.87404388 
                 5.77E−09 
                 6.20E−06 
                 10.1935268 
               
               
                 1427059_at 
                 Tmem184b 
                 1.19049436 
                 9.2053589 
                 6.80169576 
                 7.60E−09 
                 7.97E−06 
                 9.94204892 
               
               
                 1453196_a_a 
                 Oasl2 
                 1.34151303 
                 10.6174821 
                 6.77476842 
                 8.41E−09 
                 8.62E−06 
                 9.84846205 
               
               
                 1452231_x_a 
                 Mndal 
                 1.20215669 
                 12.1489677 
                 6.75397715 
                 9.10E−09 
                 9.12E−06 
                 9.77620711 
               
               
                 1417932_at 
                 Il18 
                 1.2024199 
                 8.58526778 
                 6.73898284 
                 9.63E−09 
                 9.44E−06 
                 9.72410174 
               
               
                 1420796_at 
                 Ahrr 
                 1.35482305 
                 6.39700067 
                 6.68881415 
                 1.16E−08 
                 1.12E−05 
                 9.54979119 
               
               
                 1426906_at 
                 Mndal 
                 1.22985583 
                 12.0834069 
                 6.68154198 
                 1.20E−08 
                 1.12E−05 
                 9.52452794 
               
               
                 1417244_a_a 
                 Irf7 
                 1.29690765 
                 11.8707637 
                 6.66482592 
                 1.28E−08 
                 1.17E−05 
                 9.46646104 
               
               
                 1456494_a_a 
                 Trim30a ///           
                 1.24228874 
                 10.5953269 
                 6.66073405 
                 1.29E−08 
                 1.17E−05 
                 9.45224793 
               
               
                 1445897_s_a 
                 Ifi35 
                 1.09502194 
                 13.2112571 
                 6.64901185 
                 1.35E−08 
                 1.20E−05 
                 9.41153295 
               
               
                 1418115_s_a 
                 Tor1aip2 
                 1.09066644 
                 11.3826254 
                 6.63787659 
                 1.41E−08 
                 1.22E−05 
                 9.37285954 
               
               
                 1426670_at 
                 Agrn 
                 1.16650332 
                 8.38464727 
                 6.61334752 
                 1.55E−08 
                 1.32E−05 
                 9.28767938 
               
               
                 1450783_at 
                 Ifit1 
                 1.31370421 
                 11.6154892 
                 6.57611523 
                 1.78E−08 
                 1.49E−05 
                 9.15841659 
               
               
                 1436058_at 
                 Rsad2 
                 1.44054736 
                 10.0892795 
                 6.52152657 
                 2.19E−08 
                 1.76E−05 
                 8.96897228 
               
               
                 1460603_at 
                 Samd9l 
                 1.09852241 
                 13.0008563 
                 6.48452217 
                 2.52E−08 
                 1.99E−05 
                 8.84061078 
               
               
                 1450484_a_a 
                 Cmpk2 
                 1.4069656 
                 9.18452824 
                 6.47037709 
                 2.66E−08 
                 2.06E−05 
                 8.79155778 
               
               
                 1452349_x_a 
                 Ifi205 /// Mn           
                 1.20045125 
                 7.72773058 
                 6.46703491 
                 2.69E−08 
                 2.06E−05 
                 8.77996877 
               
               
                 1435529_at 
                 Gm14446 
                 1.28471375 
                 11.9844626 
                 6.46256796 
                 2.74E−08 
                 2.06E−05 
                 8.76448031 
               
               
                 1455581_x_a 
                 Gm20559 
                 1.13805761 
                 11.6732978 
                 6.44922028 
                 2.88E−08 
                 2.09E−05 
                 8.71820419 
               
               
                 1451860_a_a 
                 Trim30a 
                 1.18244967 
                 12.1537452 
                 6.36625749 
                 3.94E−08 
                 2.82E−05 
                 8.43075121 
               
               
                 1436562_at 
                 Ddx58 
                 1.14667035 
                 11.473735 
                 6.36165042 
                 4.00E−08 
                 2.82E−05 
                 8.41479807 
               
               
                 1448380_at 
                 Lgals3bp 
                 1.16298116 
                 11.2244145 
                 6.30367575 
                 4.98E−08 
                 3.40E−05 
                 8.21414149 
               
               
                 1449025_at 
                 Ifit3 
                 1.3414478 
                 11.8181697 
                 6.30015076 
                 5.05E−08 
                 3.40E−05 
                 8.20194708 
               
               
                 1452087_at 
                 Epsti1 
                 1.11549904 
                 11.2912312 
                 6.24845347 
                 6.13E−08 
                 4.01E−05 
                 8.02318829 
               
               
                 1421009_at 
                 Rsad2 
                 1.51117184 
                 7.74253963 
                 6.2035856 
                 7.26E−08 
                 4.64E−05 
                 7.86817911 
               
               
                 1443698_at 
                 Xaf1 
                 1.18282113 
                 11.9302802 
                 6.20178329 
                 7.30E−08 
                 4.64E−05 
                 7.86195528 
               
               
                 1442130_at 
                 Hsh2d 
                 1.1709592 
                 10.2697537 
                 6.16886582 
                 8.27E−08 
                 5.18E−05 
                 7.7483219 
               
               
                 1459151_x_a 
                 Ifi35 
                 1.10594094 
                 11.6543585 
                 6.13135928 
                 9.50E−08 
                 5.87E−05 
                 7.62066485 
               
               
                 1436172_at 
                 Gm20559 
                 1.1493816 
                 11.5396111 
                 6.07854249 
                 1.16E−07 
                 7.05E−05 
                 7.43692632 
               
               
                 1448575_at 
                 Il7r 
                 1.09825437 
                 11.0940999 
                 6.07547051 
                 1.17E−07 
                 7.05E−05 
                 7.4263466 
               
               
                 1452160_at 
                 Tiparp 
                 1.11979242 
                 9.76721315 
                 6.06904538 
                 1.20E−07 
                 7.13E−05 
                 7.40422136 
               
               
                 1451050_at 
                 Nt5c3 
                 1.16150561 
                 10.6183063 
                 6.05166841 
                 1.28E−07 
                 7.51E−05 
                 7.34439991 
               
               
                 1431095_a_a 
                 Herc6 
                 1.19901119 
                 10.4733187 
                 6.04385458 
                 1.32E−07 
                 7.63E−05 
                 7.31750846 
               
               
                 1423681_at 
                 Ftsjd2 /// Rn           
                 1.09083446 
                 10.9815969 
                 6.03884145 
                 1.35E−07 
                 7.68E−05 
                 7.3002584 
               
               
                 1449143_at 
                 Rtp4 
                 1.24304662 
                 7.42935297 
                 6.02268936 
                 1.43E−07 
                 8.05E−05 
                 7.24469409 
               
               
                 1437636_at 
                 Pydc4 
                 1.33382761 
                 8.19945237 
                 6.01217359 
                 1.49E−07 
                 8.27E−05 
                 7.20853136 
               
               
                 1450495_a_a 
                 Klrk1 
                 1.14444626 
                 9.11777277 
                 5.99801423 
                 1.57E−07 
                 8.59E−05 
                 7.15985406 
               
               
                 1450276_a_a 
                 Scin 
                 1.26600893 
                 8.7352575 
                 5.99419456 
                 1.59E−07 
                 8.59E−05 
                 7.14672584 
               
               
                 1427091_at 
                 Znfx1 
                 1.16622599 
                 9.5503153 
                 5.99232677 
                 1.60E−07 
                 8.59E−05 
                 7.1403067 
               
               
                 1432026_a_a 
                 Herc6 
                 1.2332518 
                 9.6340896 
                 5.91285077 
                 2.15E−07 
                 0.00011289 
                 6.86746993 
               
               
                 1451777_at 
                 Ddx60 
                 1.2572541 
                 9.17655647 
                 5.89999373 
                 2.26E−07 
                 0.00011573 
                 6.82339016 
               
               
                 1451655_at 
                 Slfn8 
                 1.16818125 
                 11.8030813 
                 5.85259478 
                 2.69E−07 
                 0.00013591 
                 6.6610318 
               
               
                 1423071_x_a 
                 6720475J19           
                 1.12577119 
                 8.9545691 
                 5.84322799 
                 2.79E−07 
                 0.00013788 
                 6.62897522 
               
               
                 1450241_a_a 
                 Evi2a 
                 1.11124373 
                 11.3075457 
                 5.84097845 
                 2.81E−07 
                 0.00013788 
                 6.62127789 
               
               
                 1421217_a_a 
                 Lgals9 
                 1.11289495 
                 12.0356748 
                 5.83616937 
                 2.86E−07 
                 0.00013886 
                 6.60482433 
               
               
                 1424775_at 
                 Oas1a 
                 1.26381284 
                 10.9682776 
                 5.82921661 
                 2.94E−07 
                 0.00014098 
                 6.58104095 
               
               
                 1447851_x_a 
                 Atp10a 
                 1.13412363 
                 9.35777039 
                 5.81806601 
                 3.06E−07 
                 0.0001454 
                 6.54290906 
               
               
                 1451426_at 
                 Dhx58 
                 1.27494236 
                 10.5332943 
                 5.79964551 
                 3.28E−07 
                 0.00015407 
                 6.47994653 
               
               
                 1452013_at 
                 Atp10a 
                 1.16582075 
                 7.25191599 
                 5.74981475 
                 3.95E−07 
                 0.00018343 
                 6.30981665 
               
               
                 1438004_at 
                 Papd7 
                 1.15866963 
                 8.7651013 
                 5.72747713 
                 4.29E−07 
                 0.00019722 
                 6.23364804 
               
               
                 1453757_at 
                 Herc6 
                 1.25111898 
                 9.09811412 
                 5.64424695 
                 5.83E−07 
                 0.00026558 
                 5.95039163 
               
               
                 1456890_at 
                 Ddx58 
                 1.20405595 
                 8.33433728 
                 5.63983971 
                 5.93E−07 
                 0.00026723 
                 5.93541754 
               
               
                 1416697_at 
                 Dpp4 
                 1.1097733 
                 9.72105276 
                 5.63576616 
                 6.01E−07 
                 0.00026859 
                 5.92157948 
               
               
                 1422006_at 
                 Eif2ak2 
                 1.23465729 
                 9.21616067 
                 5.61858421 
                 6.41E−07 
                 0.00028336 
                 5.86323608 
               
               
                 1424617_at 
                 Ifi35 
                 1.10413772 
                 12.2660487 
                 5.60315363 
                 6.78E−07 
                 0.00029704 
                 5.8108739 
               
               
                 1426278_at 
                 Ifi27l2a 
                 1.13356673 
                 13.6135311 
                 5.55624326 
                 8.06E−07 
                 0.00034964 
                 5.65189199 
               
               
                 1452676_a_a 
                 LOC1005051           
                 1.11295467 
                 9.74168879 
                 5.53659908 
                 8.67E−07 
                 0.00037225 
                 5.58541026 
               
               
                 1451852_at 
                 Tcstv3 
                 1.22404052 
                 6.8712238 
                 5.52210287 
                 9.14E−07 
                 0.00038891 
                 5.53638704 
               
               
                 1449366_at 
                 Mmp8 
                 1.22832664 
                 9.31371883 
                 5.50428037 
                 9.76E−07 
                 0.00041133 
                 5.47615784 
               
               
                 1425405_a_a 
                 Adar 
                 1.10728732 
                 11.4786191 
                 5.48996899 
                 1.03E−06 
                 0.0004295 
                 5.42782879 
               
               
                 1429570_at 
                 Mlkl 
                 1.20072042 
                 8.28523783 
                 5.48602776 
                 1.04E−06 
                 0.00043175 
                 5.4145249 
               
               
                 1456288_at 
                 Slfn5 
                 1.32340243 
                 9.39871024 
                 5.47997663 
                 1.07E−06 
                 0.00043504 
                 5.3941035 
               
               
                 1417961_a_a 
                 Trim30a 
                 1.17912824 
                 12.8108758 
                 5.47899844 
                 1.07E−06 
                 0.00043504 
                 5.39080284 
               
               
                 1444405_at 
                 Pydc4 
                 1.32066484 
                 5.20069324 
                 5.43876125 
                 1.24E−06 
                 0.0004952 
                 5.25516142 
               
               
                 1435454_a_a 
                 Helz2 
                 1.13249361 
                 12.5204465 
                 5.43239671 
                 1.27E−06 
                 0.00050243 
                 5.23372972 
               
               
                 1430530_s_a 
                 Nmral1 
                 1.17435967 
                 9.31355989 
                 5.37375224 
                 1.57E−06 
                 0.00061706 
                 5.03656379 
               
               
                 1438148_at 
                 Cxcl3 
                 1.69044193 
                 7.09902456 
                 5.35135811 
                 1.71E−06 
                 0.00065812 
                 4.96142512 
               
               
                 1422141_s_a 
                 Csprs /// Gm           
                 1.19436756 
                 7.71681771 
                 5.33738357 
                 1.80E−06 
                 0.00068662 
                 4.91458012 
               
               
                 1418116_at 
                 Tor1aip2 
                 1.08075944 
                 10.7447031 
                 5.32686698 
                 1.87E−06 
                 0.00070743 
                 4.87934914 
               
               
                 1425065_at 
                 Oas2 
                 1.28607157 
                 10.4532534 
                 5.32376691 
                 1.89E−06 
                 0.0007095 
                 4.86896748 
               
               
                 1436778_at 
                 Cybb 
                 1.1006634 
                 12.2766584 
                 5.29025539 
                 2.13E−06 
                 0.00079482 
                 4.75685109 
               
               
                 1428346_at 
                 Trafd1 
                 1.15659445 
                 11.2650229 
                 5.28308824 
                 2.19E−06 
                 0.0008091 
                 4.73289875 
               
               
                 1440522_at 
                 Chic1 
                 1.11707615 
                 8.8938542 
                 5.26963652 
                 2.30E−06 
                 0.00084269 
                 4.68796879 
               
               
                 1418580_at 
                 Rtp4 
                 1.16283443 
                 12.43898 
                 5.25438045 
                 2.43E−06 
                 0.00088346 
                 4.63705234 
               
               
                 1425374_at 
                 Oas3 
                 1.32020993 
                 10.3330288 
                 5.23952375 
                 2.56E−06 
                 0.00092489 
                 4.58751022 
               
               
                 1435840_x_a 
                 BC147527 
                 1.21647215 
                 7.14546794 
                 5.20034393 
                 2.95E−06 
                 0.00104904 
                 4.45705855 
               
               
                 1459913_at 
                 Tnfsf10 
                 1.10617704 
                 8.60982005 
                 5.19467099 
                 3.02E−06 
                 0.00106241 
                 4.43819454 
               
               
                 1418346_at 
                 Insl6 
                 1.1375775 
                 8.67983728 
                 5.17515811 
                 3.24E−06 
                 0.00113118 
                 4.3733569 
               
               
                 1440299_at 
                 Mb21d1 
                 1.08850433 
                 8.80638297 
                 5.10764055 
                 4.13E−06 
                 0.0014208 
                 4.14959418 
               
               
                 1452306_at 
                 Zfyve26 
                 1.08114798 
                 10.6819271 
                 5.09739051 
                 4.28E−06 
                 0.00146298 
                 4.11570542 
               
               
                 1425008_a_a 
                 Gm16340 //           
                 1.14711446 
                 8.2805057 
                 5.07062975 
                 4.71E−06 
                 0.00159849 
                 4.02733237 
               
               
                 1426971_at 
                 Uba7 
                 1.0921264 
                 11.5979875 
                 5.05902098 
                 4.91E−06 
                 0.00165404 
                 3.98904342 
               
               
                 1427102_at 
                 Slfn4 
                 1.4307997 
                 10.9094731 
                 5.02506971 
                 5.55E−06 
                 0.00184054 
                 3.87722913 
               
               
                 1447272_s_a 
                 Atp10a 
                 1.16573994 
                 8.48146745 
                 5.00861675 
                 5.89E−06 
                 0.00191674 
                 3.82313389 
               
               
                 1452161_at 
                 Tiparp 
                 1.12341519 
                 9.30889526 
                 5.00763194 
                 5.91E−06 
                 0.00191674 
                 3.81989785 
               
               
                 1419668_at 
                 Sgcb 
                 1.11311815 
                 8.08482712 
                 4.99202128 
                 6.25E−06 
                 0.00201223 
                 3.7686309 
               
               
                 1452973_at 
                 Ppm1k 
                 1.06538857 
                 10.5472337 
                 4.97566869 
                 6.62E−06 
                 0.00211808 
                 3.71498595 
               
               
                 1440866_st 
                 Eif2ak2 
                 1.27644426 
                 8.72230965 
                 4.96189632 
                 6.96E−06 
                 0.00220906 
                 3.66985249 
               
               
                 1425225_at 
                 Fcgr4 
                 1.15148701 
                 7.97090773 
                 4.94964494 
                 7.27E−06 
                 0.00229151 
                 3.62973994 
               
               
                 1428843_at 
                 5-Mar 
                 1.06276216 
                 11.9004332 
                 4.89939887 
                 8.69E−06 
                 0.00270208 
                 3.46559327 
               
               
                 1455500_at 
                 Rnf213 
                 1.18104388 
                 12.9664015 
                 4.8925931 
                 8.90E−06 
                 0.00273916 
                 3.44340567 
               
               
                 1450322_s_a 
                 Slfn3 /// Slfn           
                 1.32138137 
                 7.84711588 
                 4.8916997 
                 8.93E−06 
                 0.00273916 
                 3.4404939 
               
               
                 1419569_a_a 
                 Isg20 
                 1.21173809 
                 11.9296506 
                 4.86452698 
                 9.83E−06 
                 0.00299161 
                 3.35202465 
               
               
                 1451161_a_a 
                 Emr1 
                 1.18065879 
                 9.48930222 
                 4.86302162 
                 9.88E−06 
                 0.00299161 
                 3.3471287 
               
               
                 1452348_s_a 
                 Ifi204 /// Ifi2           
                 1.22015123 
                 10.6929234 
                 4.85654465 
                 1.01E−05 
                 0.00304061 
                 3.32606974 
               
               
                 1451564_at 
                 Parp14 
                 1.13986145 
                 12.0654567 
                 4.85172709 
                 1.03E−05 
                 0.00307242 
                 3.31041282 
               
               
                 1418244_at 
                 Naa20 
                 1.08893101 
                 11.1644701 
                 4.76808963 
                 1.38E−05 
                 0.00407322 
                 3.03951865 
               
               
                 1436899_at 
                 Zufsp 
                 1.09784747 
                 11.1470022 
                 4.74873354 
                 1.48E−05 
                 0.00433173 
                 2.97708107 
               
               
                 1419599_s_a 
                 Ms4a6d 
                 1.33981893 
                 8.57140996 
                 4.74664377 
                 1.49E−05 
                 0.0043355 
                 2.97034589 
               
               
                 1443621_at 
                 Xaf1 
                 1.16509294 
                 7.24967566 
                 4.74194912 
                 1.51E−05 
                 0.00437932 
                 2.95521955 
               
               
                 1436472_at 
                 Slfn9 
                 1.11910501 
                 8.38309804 
                 4.73923193 
                 1.53E−05 
                 0.00439313 
                 2.94646731 
               
               
                 1453562_a_a 
                 Nmral1 
                 1.15341413 
                 9.19098832 
                 4.73002801 
                 1.58E−05 
                 0.00450863 
                 2.91683543 
               
               
                 1454809_at 
                 Ncoa7 
                 1.09311088 
                 10.3983869 
                 4.7257237 
                 1.60E−05 
                 0.00454843 
                 2.90298546 
               
               
                 1436779_at 
                 Cybb 
                 1.0941996 
                 11.6457179 
                 4.7126236 
                 1.68E−05 
                 0.00473241 
                 2.86086374 
               
               
                 1426970_a_a 
                 Uba7 
                 1.07523655 
                 12.3984639 
                 4.68910631 
                 1.82E−05 
                 0.00510655 
                 2.78536262 
               
               
                 1434139_at 
                 Parp11 
                 1.09338753 
                 10.840668 
                 4.6805127 
                 1.88E−05 
                 0.00522983 
                 2.75781068 
               
               
                 1452178_at 
                 Parp10 /// P           
                 1.10641059 
                 11.7358548 
                 4.66046456 
                 2.01E−05 
                 0.00552329 
                 2.6936131 
               
               
                 1417516_at 
                 Ddit3 
                 1.07223921 
                 9.94848573 
                 4.66039944 
                 2.02E−05 
                 0.00552329 
                 2.69340478 
               
               
                 1459973_x_a 
                 Dpp4 
                 1.14507385 
                 7.63353457 
                 4.65962457 
                 2.02E−05 
                 0.00552329 
                 2.69092573 
               
               
                 1422140_at 
                 Gm7609 
                 1.16864971 
                 8.39169472 
                 4.63609019 
                 2.19E−05 
                 0.00595944 
                 2.61571222 
               
               
                 1417685_at 
                 Ankfy1 
                 1.06791545 
                 11.0934338 
                 4.61188057 
                 2.39E−05 
                 0.00640602 
                 2.53850302 
               
               
                 1423627_at 
                 Nqo1 
                 1.16457475 
                 6.67427154 
                 4.59518149 
                 2.53E−05 
                 0.00674846 
                 2.48534355 
               
               
                 1451755_a_a 
                 Apobec1 
                 1.07861266 
                 9.62528811 
                 4.56307937 
                 2.83E−05 
                 0.00749855 
                 2.38337634 
               
               
                 1430700_a_a 
                 Pla2g7 
                 1.18443125 
                 10.1013856 
                 4.56135068 
                 2.84E−05 
                 0.00749945 
                 2.37789398 
               
               
                 1438948_x_a 
                 Tspo 
                 1.10391642 
                 11.5941786 
                 4.5571403 
                 2.89E−05 
                 0.0075653 
                 2.36454478 
               
               
                 1450291_s_a 
                 Ms4a4c 
                 1.12154489 
                 12.4861899 
                 4.55455972 
                 2.91E−05 
                 0.00758904 
                 2.35636554 
               
               
                 1419879_s_a 
                 Trim25 
                 1.09549971 
                 12.1244381 
                 4.5525076 
                 2.93E−05 
                 0.00759918 
                 2.34986266 
               
               
                 1428615_at 
                 Lpar6 
                 1.07528364 
                 9.93379264 
                 4.54743285 
                 2.98E−05 
                 0.00768686 
                 2.33378681 
               
               
                 1416695_at 
                 Tspo 
                 1.0780893 
                 12.4808237 
                 4.54588597 
                 3.00E−05 
                 0.00768686 
                 2.32888813 
               
               
                 1424857_a_a 
                 Trim34a 
                 1.11791554 
                 10.7165118 
                 4.53973664 
                 3.06E−05 
                 0.00780763 
                 2.30942125 
               
               
                 1446457_at 
                 Ddx58 
                 1.16007779 
                 8.02122625 
                 4.53347715 
                 3.13E−05 
                 0.00793348 
                 2.28961716 
               
               
                 1442640_at 
                 — 
                 1.2168656 
                 9.07831829 
                 4.51929521 
                 3.29E−05 
                 0.00828496 
                 2.24479093 
               
               
                 1449078_at 
                 St3gal6 
                 1.09165835 
                 10.7727541 
                 4.51684697 
                 3.32E−05 
                 0.0083088 
                 2.23705863 
               
               
                 1449591_at 
                 Casp4 
                 1.10948228 
                 11.1338558 
                 4.50971919 
                 3.40E−05 
                 0.00846848 
                 2.2145572 
               
               
                 1418030_at 
                 Slco3a1 
                 1.08661497 
                 9.54424904 
                 4.49526041 
                 3.57E−05 
                 0.00880366 
                 2.16895999 
               
               
                 1416871_at 
                 Adam8 
                 1.1193914 
                 9.62857594 
                 4.48900903 
                 3.65E−05 
                 0.00894624 
                 2.14926531 
               
               
                 1454668_at 
                 Ubr4 
                 1.12814814 
                 11.184894 
                 4.48414411 
                 3.71E−05 
                 0.0089994 
                 2.1339469 
               
               
                 1442201_at 
                 — 
                 1.1432126 
                 9.81756401 
                 4.47986246 
                 3.77E−05 
                 0.00908403 
                 2.12047102 
               
               
                 1436032_at 
                 — 
                 1.21380001 
                 11.1380493 
                 4.47297003 
                 3.86E−05 
                 0.00925232 
                 2.09878995 
               
               
                 1454169_a_a 
                 Epsti1 
                 1.12897335 
                 10.1539562 
                 4.45618995 
                 4.09E−05 
                 0.00974916 
                 2.04606725 
               
               
                 1434601_at 
                 Amigo2 
                 1.13289174 
                 9.38089015 
                 4.42595648 
                 4.53E−05 
                 0.01075628 
                 1.95129594 
               
               
                 1448576_at 
                 Il7r 
                 1.10438001 
                 9.35743301 
                 4.3992231 
                 4.96E−05 
                 0.01166251 
                 1.86773693 
               
               
                 1421550_a_a 
                 Trim34a ///           
                 1.12211108 
                 9.72957463 
                 4.39764723 
                 4.99E−05 
                 0.01166465 
                 1.86281845 
               
               
                 1415713_a_a 
                 Ddx24 
                 1.06449185 
                 11.5232541 
                 4.37956906 
                 5.31E−05 
                 0.01234241 
                 1.80645151 
               
               
                 1419667_at 
                 Sgcb 
                 1.12646472 
                 8.33509646 
                 4.34873052 
                 5.90E−05 
                 0.01363746 
                 1.71054358 
               
               
                 1455227_at 
                 Nceh1 
                 1.08446292 
                 9.91489676 
                 4.34099563 
                 6.05E−05 
                 0.01392902 
                 1.68653707 
               
               
                 1418612_at 
                 Slfn1 
                 1.09272571 
                 12.96439 
                 4.32568503 
                 6.38E−05 
                 0.01459714 
                 1.63907653 
               
               
                 1452318_a_a 
                 Hspa1b 
                 1.19057538 
                 7.25960902 
                 4.30400323 
                 6.86E−05 
                 0.01562991 
                 1.57200028 
               
               
                 1427127_x_a 
                 Hspa1b 
                 1.21832745 
                 7.30468517 
                 4.29624366 
                 7.04E−05 
                 0.01588217 
                 1.54803323 
               
               
                 1419598_at 
                 Ms4a6d 
                 1.30010562 
                 8.68960331 
                 4.29561853 
                 7.06E−05 
                 0.01588217 
                 1.54610327 
               
               
                 1448303_at 
                 Gpnmb 
                 1.22944041 
                 8.9049785 
                 4.29482104 
                 7.08E−05 
                 0.01588217 
                 1.54364139 
               
               
                 1435660_at 
                 LOC664787 
                 1.08388982 
                 8.74033836 
                 4.29173015 
                 7.15E−05 
                 0.01596949 
                 1.5341017 
               
               
                 1422511_a_a 
                 Ogfr 
                 1.07234468 
                 12.3938197 
                 4.24109747 
                 8.48E−05 
                 0.01875548 
                 1.37829561 
               
               
                 1437176_at 
                 Nlrc5 
                 1.07682641 
                 12.3735454 
                 4.23387901 
                 8.69E−05 
                 0.01912232 
                 1.35615536 
               
               
                 1436633_at 
                 Gm11772 
                 1.14601474 
                 4.72784952 
                 4.22090965 
                 9.08E−05 
                 0.01980988 
                 1.316422 
               
               
                 1451082_at 
                 Ftsjd2 /// R           
                 1.06640728 
                 11.3628274 
                 4.2204656 
                 9.09E−05 
                 0.01980988 
                 1.31506267 
               
               
                 1425974_a_a 
                 Trim25 
                 1.08480215 
                 11.7657133 
                 4.20895728 
                 9.45E−05 
                 0.02049028 
                 1.27985683 
               
               
                 1417876_at 
                 Fcgr1 
                 1.2323332 
                 7.0806629 
                 4.19894373 
                 9.77E−05 
                 0.0210878 
                 1.24926191 
               
               
                 1457069_at 
                 Ascc3 
                 1.11288948 
                 9.43740297 
                 4.19582127 
                 9.87E−05 
                 0.02120788 
                 1.23972903 
               
               
                 1429831_at 
                 Pik3ap1 
                 1.06680759 
                 12.4737143 
                 4.1806008 
                 0.0001039 
                 0.0222095 
                 1.19331067 
               
               
                 1449538_a_a 
                 Gcnt1 
                 1.11915617 
                 8.47448492 
                 4.14722631 
                 0.00011614 
                 0.02447684 
                 1.09181994 
               
               
                 1422005_at 
                 Eif2ak2 
                 1.19563857 
                 9.53538322 
                 4.12771094 
                 0.00012393 
                 0.02599698 
                 1.03266263 
               
               
                 1449875_s_a 
                 H2-T10 /// H           
                 1.04842787 
                 12.8867189 
                 4.11331035 
                 0.00013 
                 0.02714397 
                 0.98909995 
               
               
                 1418722_at 
                 Ngp 
                 1.11092189 
                 12.7881149 
                 4.10510418 
                 0.00013359 
                 0.02776429 
                 0.96431022 
               
               
                 1426133_a_           
                 Mitd1 
                 1.10636222 
                 10.1667831 
                 4.07764709 
                 0.00014629 
                 0.03009875 
                 0.88154944 
               
               
                 1424354_at 
                 Tmem140 
                 1.11754478 
                 9.34810202 
                 4.07577197 
                 0.0001472 
                 0.03009875 
                 0.87590785 
               
               
                 1423052_at 
                 Arf4 
                 1.05369833 
                 12.3484921 
                 4.06902312 
                 0.00015052 
                 0.03046771 
                 0.85561388 
               
               
                 1456251_x_a 
                 Tspo 
                 1.1023499 
                 11.1159008 
                 4.06877418 
                 0.00015065 
                 0.03046771 
                 0.85486562 
               
               
                 1423986_a_a 
                 Shisa5 
                 1.04210813 
                 14.2786011 
                 4.03888346 
                 0.00016625 
                 0.03347242 
                 0.76519512 
               
               
                 1428378_at 
                 Zc3hav1 
                 1.08752006 
                 10.7288018 
                 4.02875397 
                 0.00017188 
                 0.0343001 
                 0.73488508 
               
               
                 1420401_a_a 
                 Ramp3 
                 1.12512462 
                 9.98404572 
                 4.00377593 
                 0.00018656 
                 0.0370668 
                 0.66031463 
               
               
                 1460657_at 
                 Wnt10a 
                 1.12684061 
                 8.35987776 
                 3.98317991 
                 0.00019958 
                 0.03947847 
                 0.59901024 
               
               
                 1424444_a_a 
                 1600014C10           
                 1.09898446 
                 11.5959589 
                 3.98018984 
                 0.00020154 
                 0.03969221 
                 0.59012418 
               
               
                 1428444_at 
                 Asb2 
                 1.13292232 
                 8.24932226 
                 3.95719355 
                 0.00021725 
                 0.04241625 
                 0.52190117 
               
               
                 1439814_at 
                 Atp8b4 
                 1.11510444 
                 9.33960673 
                 3.95146957 
                 0.00022134 
                 0.04302868 
                 0.50495269 
               
               
                 1429588_at 
                 2810474O19           
                 1.05637397 
                 11.2428969 
                 3.93455457 
                 0.00023387 
                 0.04526887 
                 0.4549451 
               
               
                 1433617_s_a 
                 B4galt5 
                 1.11846333 
                 10.5599476 
                 3.92169381 
                 0.00024385 
                 0.04679878 
                 0.41700096 
               
               
                 1431296_at 
                 Gpr15 
                 1.14301562 
                 6.60205175 
                 3.9193265 
                 0.00024573 
                 0.04695995 
                 0.41002381 
               
               
                 1454757_s_a 
                 Ifi27l1 
                 −1.1515249 
                 11.2428344 
                 −6.5569053 
                 1.92E−08 
                 1.57E−05 
                 9.09173948 
               
               
                 1415837_at 
                 Klk1 
                 −1.4082454 
                 7.5804401 
                 −6.3275656 
                 4.55E−08 
                 3.16E−05 
                 8.29680484 
               
               
                 1452956_a_a 
                 Ifi27l1 
                 −1.1424326 
                 10.7927481 
                 −5.9606126 
                 1.80E−07 
                 9.56E−05 
                 7.03136178 
               
               
                 1448107_x_a 
                 Klk1 
                 −1.3445567 
                 7.49119412 
                 −5.9058876 
                 2.21E−07 
                 0.00011452 
                 6.84359495 
               
               
                 1439771_s_a 
                 D13ERTD608           
                 −1.2546842 
                 8.86787505 
                 −5.8507689 
                 2.71E−07 
                 0.00013591 
                 6.65478212 
               
               
                 1415823_at 
                 Scd2 
                 −1.3537166 
                 10.2235672 
                 −5.1396945 
                 3.68E−06 
                 0.00127567 
                 4.25571056 
               
               
                 1442544_at 
                 Ighm 
                 −1.1737796 
                 9.42424035 
                 −5.0083987 
                 5.89E−06 
                 0.00191674 
                 3.82241733 
               
               
                 1415824_at 
                 Scd2 
                 −1.3093243 
                 10.9433795 
                 −4.6149411 
                 2.36E−05 
                 0.00637618 
                 2.54825457 
               
               
                 1415822_at 
                 Scd2 
                 −1.2780512 
                 11.8313256 
                 −4.5073901 
                 3.43E−05 
                 0.00848983 
                 2.20720796 
               
               
                 1429100_at 
                 Ccdc71l 
                 −1.0849357 
                 10.7147161 
                 −4.4868075 
                 3.68E−05 
                 0.00896553 
                 2.14233223 
               
               
                 1427756_x_a 
                 Ighm 
                 −1.1707153 
                 9.14115987 
                 −4.4212385 
                 4.61E−05 
                 0.01087406 
                 1.93653267 
               
               
                 1449325_at 
                 Fads2 
                 −1.1644392 
                 8.52583689 
                 −4.1780844 
                 0.00010478 
                 0.02229136 
                 1.18564443 
               
               
                 1416188_at 
                 Gm2a 
                 −1.0836296 
                 10.9313169 
                 −4.163994 
                 0.00010983 
                 0.02325521 
                 1.1427593 
               
               
                 1424567_at 
                 Tspan2 
                 −1.1339633 
                 9.59951853 
                 −4.0339051 
                 0.00016899 
                 0.03387392 
                 0.75029377 
               
               
                 1436131_at 
                 Siglech 
                 −1.1248775 
                 7.91450702 
                 −3.9583983 
                 0.0002164 
                 0.04241625 
                 0.52546999 
               
               
                   
               
               
                             indicates data missing or illegible when filed 
               
             
          
         
       
     
       Polimunol and Copaxone® Comparison: Differentially Expressed Pathways, Under Copaxone® Immunization 
       [0408]    After imposing a conservative fold change filter of |FC|≧1.2, 73 probesets are found to be upregulated by Polimunol relative to Copaxone® (medium-corrected, in Copaxone®-immunized mice), and these probesets enrich for 22 pathways, including immune response and response to virus. These pathways may be relevant to Copaxone&#39;s mechanism of action; several of these pathways are also enriched among probesets modulated by Copaxone® relative to control (e.g., immune response and immune system process). A total of 6 downregulated probesets are detected, which do not enrich for pathways. The upregulated pathways are depicted in  FIG. 30  and the full list of pathways enriched among top probesets upregulated by Polimunol relative to Copaxone® is provided in Table 21. 
         [0000]    
       
         
               
             
               
               
               
               
               
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 21 
               
             
             
               
                   
               
               
                 Pathways enriched among top probesets upregulated by 
               
               
                 Polimunol relative to Copaxone ® (in Copaxone ® -immunized mice). 
               
             
          
           
               
                 Category 
                 Term 
                 Count 
                 Pvalue 
                 Fold Enrichm 
                 Benjamini 
               
               
                   
               
             
          
           
               
                 GOTERM_BP_ALL 
                 GO: 0006955~immune response 
                 15 
                 4.38E−11 
                 9.95074106 
                 1.98E−08 
               
               
                 GOTERM_BP_ALL 
                 GO: 0009615~response to virus 
                 8 
                 8.16E−10 
                 38.2602137 
                 1.84E−07 
               
               
                 GOTERM_BP_ALL 
                 GO: 0002376~immune system process 
                 15 
                 8.29E−08 
                 5.57817311 
                 9.35E−06 
               
               
                 GOTERM_BP_ALL 
                 GO: 0051707~response to other organism 
                 9 
                 8.19E−08 
                 14.9261116 
                 1.23E−05 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050896~response to stimulus 
                 21 
                 1.38E−07 
                 3.37128932 
                 1.25E−05 
               
               
                 GOTERM_BP_ALL 
                 GO: 0009607~response to biotic stimulus 
                 9 
                 1.27E−06 
                 10.4567109 
                 9.54E−05 
               
               
                 GOTERM_BP_ALL 
                 GO: 0051704~multi-organism process 
                 9 
                 1.63E−06 
                 10.113868 
                 0.00010525 
               
               
                 KEGG_PATHWAY 
                 mmu04622: RIG-1-like receptor signaling pathway 
                 5 
                 1.47E−05 
                 27.2429078 
                 0.00023467 
               
               
                 KEGG_PATHWAY 
                 mmu04623: Cytosolic DNA-sensing pathway 
                 4 
                 0.00031378 
                 25.6083333 
                 0.00250745 
               
               
                 GOTERM_BP_ALL 
                 GO: 0045087~innate immune response 
                 5 
                 0.00030987 
                 14.6891892 
                 0.01731968 
               
               
                 GOTERM_MF_ALL 
                 GO: 0001882~nucleoside binding 
                 16 
                 0.00118891 
                 2.41112097 
                 0.02621825 
               
               
                 GOTERM_MF_ALL 
                 GO: 0032559~adenyl ribonucleotide binding 
                 16 
                 0.00065908 
                 2.54969114 
                 0.02901942 
               
               
                 GOTERM_MF_ALL 
                 GO: 0001883~purine nucleoside binding 
                 16 
                 0.00112323 
                 2.42429649 
                 0.02967043 
               
               
                 GOTERM_BP_ALL 
                 GO: 0006952~defense response 
                 7 
                 0.00060685 
                 6.34158828 
                 0.02996091 
               
               
                 GOTERM_MF_ALL 
                 GO: 0030554~adenyl nucleotide binding 
                 16 
                 0.00106069 
                 2.4376168 
                 0.03492727 
               
               
                 GOTERM_MF_ALL 
                 GO: 0032553~ribonucleotide binding 
                 17 
                 0.00211744 
                 2.18735104 
                 0.03976457 
               
               
                 GOTERM_MF_ALL 
                 GO: 0032555~purine ribonucleotide binding 
                 17 
                 0.00211744 
                 2.18735104 
                 0.03976457 
               
               
                 GOTERM_MF_ALL 
                 GO: 0005524~ATP binding 
                 16 
                 0.00061962 
                 2.56442924 
                 0.04067708 
               
               
                 GOTERM_MF_ALL 
                 GO: 0001730~2′-5′-oligoadenylate synthetase activity 
                 3 
                 0.0003357 
                 99.8204082 
                 0.04399453 
               
               
                 GOTERM_MF_ALL 
                 GO: 0017076~purine nucleotide binding 
                 17 
                 0.00310625 
                 2.1090566 
                 0.04526422 
               
               
                 GOTERM_MF_ALL 
                 GO: 0016779~nucleotidyltransferase activity 
                 5 
                 0.00284393 
                 8.23600727 
                 0.04658368 
               
               
                 GOTERM_MF_ALL 
                 GO: 0003723~RNA binding 
                 10 
                 0.00371417 
                 3.08659271 
                 0.04863977 
               
               
                   
               
             
          
         
       
     
       Polimunol/Copaxone® Comparison: Differentially Expressed Pathways, Polimunol Immunization 
       [0409]    In Polimunol-immunized mice, after imposing a fold change filter of |FC|≧ 1 . 2 , 77 probesets are upregulated by Polimunol relative to Copaxone® (medium-corrected, in Polimunol-immunized mice), and these probesets enrich for 10 pathways. These pathways are similar to those seen in the comparison for Copaxone®-immunized mice, and include pathways relevant to Copaxone&#39;s mechanism of action such as immune response and immune system process pathways, as well as potentially concerning pathways such as response to virus. 22 downregulated probesets are detected, which do not enrich for pathways. The upregulated pathways are depicted in  FIG. 31  and provided in Table 22. 
         [0000]    
       
         
               
             
               
               
               
               
               
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 22 
               
             
             
               
                   
               
               
                 Pathways enriched among top probesets upregulated by 
               
               
                 Polimunol relative to Copaxone ® (in Polimunol-immunized mice). 
               
             
          
           
               
                 Category 
                 Term 
                 Count 
                 Pvalue 
                 Fold Enrichm 
                 Benjamini 
               
               
                   
               
             
          
           
               
                 GOTERM_BP_ALL 
                 GO: 0009615~response to virus 
                 8 
                 3.62E−09 
                 31.4583979 
                 1.93E−06 
               
               
                 GOTERM_BP_ALL 
                 GO: 0009607~response to biotic stimulus 
                 11 
                 4.50E−08 
                 10.508349 
                 1.20E−05 
               
               
                 GOTERM_BP_ALL 
                 GO: 0051707~response to other organism 
                 9 
                 4.30E−07 
                 12.2725806 
                 5.73E−05 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050896~response to stimulus 
                 23 
                 3.87E−07 
                 3.03594414 
                 6.88E−05 
               
               
                 GOTERM_BP_ALL 
                 GO: 0051704~multi-organism process 
                 10 
                 7.59E−07 
                 9.23982999 
                 8.09E−05 
               
               
                 GOTERM_BP_ALL 
                 GO: 0006955~immune response 
                 12 
                 9.89E−07 
                 6.54537634 
                 8.78E−05 
               
               
                 GOTERM_BP_ALL 
                 GO: 0002376~immune system process 
                 12 
                 0.0002277 
                 3.66919831 
                 0.01719059 
               
               
                 GOTERM_CC_ALL 
                 GO: 0044421~extracellular region part 
                 7 
                 0.00098754 
                 5.86744639 
                 0.03589677 
               
               
                 GOTERM_CC_ALL 
                 GO: 0005576~extracellular region 
                 10 
                 0.00051394 
                 4.06619385 
                 0.03732702 
               
               
                 GOTERM_CC_ALL 
                 GO: 0005615~extracellular space 
                 6 
                 0.00178939 
                 6.62813102 
                 0.04321627 
               
               
                   
               
             
          
         
       
     
       Polimunol and Copaxone Comparison: Discussion 
       [0410]    The fact that Polimunol modulates IL18 to a significantly different extent than Copaxone®, consistently, regardless of immunization agent is noteworthy and has potential implications for both safety and efficacy. IL18 is important for T helper cell differentiation, and IL18 levels are higher in serum from MS patients versus controls, as well as acute versus stable MS (Nicoletti et al, 2001). The signaling pathway for IL-18 appears in  FIG. 32 a   . IL18 also induces IFNg expression and has been implicated in MS immunopathogenesis (Losy et al, 2001). IL18 genetic variants have further been shown to affect MS risk (Celik et al, 2014; Thompson et al, 2007). Moreover, mice deficient for IL18 are resistant to EAE (Shi et al, J. Immunol., 2000) as shown in  FIG. 32   b.    
         [0411]    Intriguingly, a number of interferon-related genes are upregulated by Polimunol relative to Copaxone® in this model system.  FIG. 33  shows illustrated pathways of IFN Type I production (Trinchieri et al, J Exp Med, 2010), with overlay indicating genes including RIG-I, MDA5, and IRF7 upregulated by Polimunol versus Copaxone. As the figure indicates, the upregulation of these genes would be consistent with an increase in type I interferon production. 
         [0412]    At the pathway level, the fact that a variety of immune-related pathways are enriched among the differentially expressed probesets, including “immune system process” and “response to virus,” and that differential expression is seen for multiple genes affecting interferon signaling (e.g. leading to the significant enrichment of the RIG-I-like receptor signaling pathway in the comparison between Polimunol and Copaxone® in Copaxone-immunized mice), raises serious concerns for safety and efficacy. 
       Example 11 
     Differences in Gene Expression Induced by Polimunol Versus Branded GA in Human Monocyte (THP-1) Gene Expression Studies 
       [0413]    The immunized mouse splenocyte model system has proved robust and informative in examining Copaxone®&#39;s mode of action, as well as in differentiating between seemingly similar FOGAs and Copaxone® [Bakshi et al, 2013; Towfic et al, 2014; FDA-2014-P-0933-0001 available at www.regulations.gov/#?documentDetail;D=FDA-2014-P-0933-0001, and also described herein; and FDA-2013-P-1641-0001 available at www.regulations.gov/#?documentDetail;D=FDA-2013-P-1641-000l, and also described herein. To follow up on these findings and test a human-source model system, THP-1 cells were utilized. The research community uses this human monocyte cell line to model the behavior of antigen-presenting cells. As described in further detail in the methods section below, THP-1 cells were utilized to (1) compare the genome-wide transcriptional impact of Copaxone® to that of a mannitol control, in order to shed additional light on Copaxone®&#39;s mechanism of action (MoA), and to (2) compare the genome-wide transcriptional impact of Copaxone® to that of purported generics, including Polimunol. It is critical to methodologically pursue the MoA analyses first and independently of any subsequent investigations so as to ensure the validity and robustness of each experiment. To this end, at least three different batches of Copaxone are tested and analyzed in comparison to control and to prior similar studies. 
         [0414]    The study was performed in two repeats identical in design, reagents, drug lots, and technicians, performed on different days. Six replicate samples for each condition were utilized in each of the two experimental runs for a total of twelve replicates per condition, making this study well powered to detect changes in expression levels across conditions. 
       Copaxone®-Modulated Genes (MoA) 
       [0415]    Copaxone® significantly upregulated 5296 probesets, and significantly downregulated 6819 probesets, out of &gt;25,000 probesets called present on the chip. Consistent with previous studies (e.g. FDA-2014-P-0933-0001 available at www.regulations.gov/#?documentDetail;D=FDA-2014-P-0933-0001, and also described herein), the anti-inflammatory gene IL1RN was strongly upregulated by Copaxone® (all 3 IL1RN probesets that were called present in the study: FDR p values&lt;6.2e-21, 2.6e-17, 8.0e-14); see  FIG. 34 a   - c.    
         [0416]    IL10 was not upregulated significantly, but may have been difficult to detect because the single probeset on the chip was not present. IL1ORA, representing the receptor necessary for IL10 signaling, was significantly upregulated (FDR p&lt;1.7e-21), indicating this pathway upregulated by Copaxone®, as expected. These results are consistent with the results of a prior study presented earlier, of which the currently discussed data represents two independent confirmatory datasets (FDA-2014-P-0933-0001 available at www.regulations.gov/#?documentDetail;D=FDA-2014-P-0933-0001, and also described herein). 
         [0417]    To test concordance with previous observations in the same model system, sets of top probesets modulated by Copaxone® were defined based on two prior THP-1 studies (FDA-2014-P-0933-0001 available at www.regulations.gov/#?documentDetail;D=FDA-2014-P-0933-0001, and also described herein), by taking the intersection of the top probesets (subject to fold change (FC) filter of 1.5, treating up and downregulated probesets separately) modulated by Copaxone® across both prior datasets (see Table 23). Significant enrichment of these sets by directionality was found in the present dataset among probesets upregulated by Copaxone® versus mannitol (FC≧1.5) and probesets downregulated by Copaxone® versus mannitol (FC≦−1.5) by the hypergeometric test: 2.4e-10 and 7.6e-11 for up and downregulated sets, respectively. 
         [0000]    
       
         
               
             
               
               
               
               
             
               
               
               
               
             
           
               
                 TABLE 23 
               
             
             
               
                   
               
               
                 Top probesets modulated by Copaxone ® are significantly 
               
               
                 enriched among the top probesets modulated by 
               
               
                 Copaxone ® in prior THP-1 studies. 
               
             
          
           
               
                   
                 In two prior 
                 In current 
                   
               
               
                   
                 THP-1 studies 
                 study 
                 Intersection 
               
               
                   
               
             
          
           
               
                 Probesets upregulated by 
                 149 
                 156 
                 94 
               
               
                 Copaxone versus mannitol 
                   
                   
                   
               
               
                 with FC ≧ 1.5 
                   
                   
                   
               
               
                 Probesets downregulated 
                 15 
                 28 
                 9 
               
               
                 by Copaxone versus 
                   
                   
                   
               
               
                 mannitol with FC ≦ −1.5 
               
               
                   
               
             
          
         
       
     
       Copaxone®-Modulated Pathways 
       [0418]    Among the top probesets upregulated by Copaxone® with FC≧1.3, 180 pathways were enriched. This includes immune response, immune system process, and cytokine-cytokine receptor interaction and regulation of B cell activation (as observed in prior THP-1 studies, e.g. FDA-2014-P-0933-0001 available at www.regulations.gov/#?documentDetail;D=FDA-2014-P-0933-0001, and also described herein) as well as coagulation, positive regulation of lymphocyte activation and proliferation, and positive regulation of B-cell activation and proliferation. The full list of pathways entiched among top probesets differentially expressed by Copaxone® relative to mannitol control in THP-1 cells is provided in Table 24. 
         [0000]    
       
         
               
             
               
               
               
               
               
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 24 
               
             
             
               
                   
               
               
                 Pathways significantly enriched among top probesets 
               
               
                 differently expressed by Copaxone ® relative to mannitol control in THP-1 cells. 
               
             
          
           
               
                 Category 
                 Term 
                 Count 
                 Pvalue 
                 Fold Enrichm 
                 Benjamini 
               
               
                   
               
             
          
           
               
                 DOWN 
                   
                   
                   
                   
                   
               
               
                 GOTERM_BP_ALL 
                 GO: 0048513~organ development 
                 30 
                 2.78E−06 
                 2.52785617 
                 0.00198109 
               
               
                 GOTERM_BP_ALL 
                 GO: 0032502~developmental process 
                 44 
                 2.37E−06 
                 1.99322239 
                 0.00337678 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048856~anatomical structure development 
                 36 
                 1.55E−05 
                 2.07315026 
                 0.00550192 
               
               
                 GOTERM_BP_ALL 
                 GO: 0016337~cell-cell adhesion 
                 10 
                 1.38E−05 
                 6.80689385 
                 0.00654548 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048731~system development 
                 33 
                 3.08E−05 
                 2.11219642 
                 0.00874514 
               
               
                 GOTERM_BP_ALL 
                 GO: 0007275~multicellular organismal development 
                 37 
                 8.63E−05 
                 1.88932377 
                 0.0203102 
               
               
                 UP 
                   
                   
                   
                   
                   
               
               
                 GOTERM_CC_ALL 
                 GO: 0005886~plasma membrane 
                 122 
                 2.34E−25 
                 2.51413927 
                 5.85E−23 
               
               
                 GOTERM_CC_ALL 
                 GO: 0031226~intrinsic to plasma membrane 
                 58 
                 6.43E−19 
                 3.81223099 
                 8.04E−17 
               
               
                 GOTERM_BP_ALL 
                 GO: 0009611~response to wounding 
                 44 
                 2.00E−19 
                 3.2102973 
                 2.16E−16 
               
               
                 GOTERM_BP_ALL 
                 GO: 0009605~response to external stimulus 
                 58 
                 1.09E−19 
                 3.93471319 
                 2.34E−16 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050896~response to stimulus 
                 118 
                 6.20E−19 
                 2.15982642 
                 4.45E−16 
               
               
                 GOTERM_CC_ALL 
                 GO: 0005887~integral to plasma membrane 
                 56 
                 7.55E−18 
                 3.73686273 
                 6.29E−16 
               
               
                 GOTERM_BP_ALL 
                 GO: 0006955~immune response 
                 46 
                 7.16E−17 
                 4.268938 
                 4.79E−14 
               
               
                 GOTERM_BP_ALL 
                 GO: 0002376~immune system process 
                 59 
                 7.00E−17 
                 3.37823803 
                 5.97E−14 
               
               
                 GOTERM_CC_ALL 
                 GO: 0016020~membrane 
                 174 
                 1.26E−14 
                 1.56061376 
                 6.33E−13 
               
               
                 GOTERM_CC_ALL 
                 GO: 0005576~extracellular region 
                 58 
                 1.03E−14 
                 3.10216639 
                 6.45E−13 
               
               
                 GOTERM_BP_ALL 
                 GO: 0006932~defense response 
                 40 
                 1.08E−14 
                 4.30462838 
                 3.86E−12 
               
               
                 GOTERM_CC_ALL 
                 GO: 0044439~plasma membrane part 
                 76 
                 9.39E−14 
                 2.43596934 
                 4.00E−12 
               
               
                 GOTERM_MF_ALL 
                 GO: 0004888~transmembrane receptor activity 
                 39 
                 4.19E−14 
                 4.23233219 
                 8.19E−12 
               
               
                 GOTERM_MF_ALL 
                 GO: 0060089~molecular transducer activity 
                 69 
                 3.91E−14 
                 2.64236631 
                 1.15E−11 
               
               
                 GOTERM_MF_ALL 
                 GO: 0004871~signal transducer activity 
                 69 
                 3.91E−14 
                 2.64356631 
                 1.15E−11 
               
               
                 GOTERM_MF_ALL 
                 GO: 0004872~receptor activity 
                 56 
                 3.49E−14 
                 3.09677878 
                 2.05E−11 
               
               
                 GOTERM_CC_ALL 
                 GO: 0044421~extracellular region part 
                 37 
                 1.44E−12 
                 4.00069218 
                 3.16E−11 
               
               
                 GOTERM_BP_ALL 
                 GO: 0006934~inflammatory response 
                 28 
                 1.16E−12 
                 5.37828278 
                 3.57E−10 
               
               
                 GOTERM_CC_ALL 
                 GO: 0031234~intrinsic to membrane 
                 125 
                 9.85E−11 
                 1.63813557 
                 3.08E−09 
               
               
                 GOTERM_CC_ALL 
                 GO: 0016021~integral to membrane 
                 121 
                 2.99E−10 
                 1.63586081 
                 8.31E−09 
               
               
                 GOTERM_CC_ALL 
                 GO: 0044425~membrane part 
                 146 
                 1.37E−09 
                 1.49687764 
                 3.43E−08 
               
               
                 KEGG_PATHWAY 
                 hsa04060: Cytokine-cytokine receptor interaction 
                 21 
                 4.90E−10 
                 3.38268996 
                 5.00E−08 
               
               
                 GOTERM_CC_ALL 
                 GO: 0005615~extracellular space 
                 27 
                 2.52E−09 
                 4.02507822 
                 5.72E−08 
               
               
                 GOTERM_BP_ALL 
                 GO: 0006930~response to stress 
                 70 
                 5.34E−10 
                 2.13148534 
                 1.44E−07 
               
               
                 GOTERM_BP_ALL 
                 GO: 0042060~wound healing 
                 19 
                 7.93E−10 
                 6.27722433 
                 1.90E−07 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050793~regulation of developmental process 
                 38 
                 9.55E−10 
                 3.11524781 
                 2.06E−07 
               
               
                 GOTERM_BP_ALL 
                 GO: 0031501~multicellular organismal process 
                 103 
                 1.58E−09 
                 1.72386846 
                 3.09E−07 
               
               
                 GOTERM_BP_ALL 
                 GO: 0031239~regulation of multicellular organismal process 
                 43 
                 2.23E−09 
                 2.76388129 
                 4.03E−07 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048731~system development 
                 74 
                 2.51E−09 
                 1.99902 
                 4.15E−07 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048314~blood vessel morphogenesis 
                 20 
                 5.89E−09 
                 5.24413041 
                 9.07E−07 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048383~regulation of response to stimulus 
                 29 
                 6.99E−09 
                 3.58839948 
                 9.41E−07 
               
               
                 GOTERM_BP_ALL 
                 GO: 0040011~locomotion 
                 27 
                 6.77E−09 
                 3.82844041 
                 9.71E−07 
               
               
                 GOTERM_BP_ALL 
                 GO: 0007165~signal transduction 
                 79 
                 1.11E−08 
                 1.87343671 
                 1.40E−06 
               
               
                 GOTERM_BP_ALL 
                 GO: 0001568~blood vessel development 
                 21 
                 1.27E−08 
                 4.73204438 
                 1.52E−06 
               
               
                 GOTERM_BP_ALL 
                 GO: 0001944~vasculature development 
                 21 
                 1.61E−08 
                 4.68782736 
                 1.82E−06 
               
               
                 GOTERM_MF_ALL 
                 GO: 0019933~cytokine binding 
                 14 
                 1.61E−08 
                 7.82935604 
                 2.36E−06 
               
               
                 GOTERM_BP_ALL 
                 GO: 0065008~regulation of biological quality 
                 55 
                 3.55E−08 
                 2.18138206 
                 3.82E−06 
               
               
                 GOTERM_BP_ALL 
                 GO: 0001525~angiogenesis 
                 16 
                 6.27E−08 
                 5.87342628 
                 6.43E−06 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048856~anatomical structure development 
                 75 
                 9.87E−08 
                 1.82463307 
                 9.66E−06 
               
               
                 GOTERM_BP_ALL 
                 GO: 0002682~regulation of immune system process 
                 23 
                 1.35E−07 
                 3.52970329 
                 1.26E−05 
               
               
                 GOTERM_CC_ALL 
                 GO: 0009986~cell surface 
                 20 
                 6.73E−07 
                 3.93630209 
                 1.40E−05 
               
               
                 GOTERM_BP_ALL 
                 GO: 0007275~multicellular organismal development 
                 80 
                 3.39E−07 
                 1.72409773 
                 3.04E−05 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048513~organ development 
                 56 
                 5.42E−07 
                 1.99152773 
                 4.67E−05 
               
               
                 GOTERM_BP_ALL 
                 GO: 0032502~developmental process 
                 86 
                 7.67E−07 
                 1.64425345 
                 6.11E−05 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048584~positive regulation of response to stimulus 
                 18 
                 7.65E−07 
                 4.30930732 
                 6.33E−05 
               
               
                 GOTERM_BP_ALL 
                 GO: 0002684~positive regulation of immune system process 
                 18 
                 8.48E−07 
                 4.27830511 
                 6.52E−05 
               
               
                 GOTERM_BP_ALL 
                 GO: 0016477~cell migration 
                 19 
                 1.39E−06 
                 3.92326521 
                 0.00010335 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048318~positive regulation of biological process 
                 70 
                 1.76E−06 
                 1.74540498 
                 0.00012637 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048519~negative regulation of biological process 
                 65 
                 2.99E−06 
                 1.77184118 
                 0.00020737 
               
               
                 GOTERM_BP_ALL 
                 GO: 0032101~regulation of response to external stimulus 
                 13 
                 3.24E−06 
                 5.50633714 
                 0.00021167 
               
               
                 GOTERM_BP_ALL 
                 GO: 0007168~cell surface receptor linked signal transduction 
                 43 
                 3.17E−06 
                 2.13308554 
                 0.00021349 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048870~cell motility 
                 19 
                 3.65E−06 
                 3.67089141 
                 0.00023142 
               
               
                 GOTERM_BP_ALL 
                 GO: 0051674~localization of cell 
                 19 
                 3.65E−06 
                 3.67089142 
                 0.00023142 
               
               
                 GOTERM_BP_ALL 
                 GO: 0051707~response to other organism 
                 18 
                 3.91E−06 
                 3.83667362 
                 0.00024052 
               
               
                 GOTERM_CC_ALL 
                 GO: 0031012~extracellular matrix 
                 14 
                 1.81E−05 
                 4.34038261 
                 0.00034771 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050878~regulation of body fluid levels 
                 12 
                 5.88E−06 
                 5.7457431 
                 0.00035133 
               
               
                 GOTERM_BP_ALL 
                 GO: 0006928~cell motion 
                 24 
                 6.70E−06 
                 2.92587656 
                 0.00038982 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050776~regulation of immune response 
                 16 
                 7.15E−06 
                 4.09773926 
                 0.00040481 
               
               
                 GOTERM_BP_ALL 
                 GO: 0042127~regulation of cell proliferation 
                 34 
                 8.23E−06 
                 2.32085284 
                 0.00043212 
               
               
                 GOTERM_BP_ALL 
                 GO: 0022603~regulation of anatomical structure morphogenesis 
                 16 
                 7.86E−06 
                 4.06621819 
                 0.000434 
               
               
                 GOTERM_BP_ALL 
                 GO: 0042330~taxis 
                 13 
                 8.15E−06 
                 5.05287408 
                 0.00043846 
               
               
                 GOTERM_BP_ALL 
                 GO: 0006935~chemotaxis 
                 13 
                 8.15E−06 
                 5.05287408 
                 0.00043846 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048646~anatomical structure formation involved in 
                 21 
                 8.68E−06 
                 3.18256183 
                 0.00044506 
               
               
                   
                 morphogenesis 
                   
                   
                   
                   
               
               
                 GOTERM_BP_ALL 
                 GO: 0065007~biological regulation 
                 170 
                 9.39E−06 
                 1.25760499 
                 0.00046996 
               
               
                 GOTERM_BP_ALL 
                 GO: 0042221~response to chemical stimulus 
                 47 
                 1.17E−05 
                 1.94341311 
                 0.00057284 
               
               
                 GOTERM_BP_ALL 
                 GO: 0002703~regulation of leukocyte mediated immunity 
                 9 
                 1.37E−05 
                 7.82479488 
                 0.00064059 
               
               
                 GOTERM_BP_ALL 
                 GO: 0007626~locomotory behavior 
                 16 
                 1.37E−05 
                 3.88682621 
                 0.00065406 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050865~regulation of cell activation 
                 14 
                 1.49E−05 
                 4.40506971 
                 0.00068044 
               
               
                 GOTERM_MF_ALL 
                 GO: 0019838~growth factor binding 
                 11 
                 5.88E−06 
                 6.46443198 
                 0.00069034 
               
               
                 GOTERM_BP_ALL 
                 GO: 0002822~regulation of adaptive immune response based on 
                 9 
                 1.68E−05 
                 7.62415911 
                 0.00075234 
               
               
                   
                 somatic recombination of immune receptors built from immunoglobulin 
                   
                   
                   
                   
               
               
                   
                 superfamily domains 
                   
                   
                   
                   
               
               
                 GOTERM_BP_ALL 
                 GO: 0002819~regulation of adaptive immune response 
                 9 
                 2.04E−05 
                 7.43355513 
                 0.0008974 
               
               
                 GOTERM_BP_ALL 
                 GO: 0030154~cell differentiation 
                 49 
                 2.72E−05 
                 1.848017258 
                 0.00116853 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048522~positive regulation of cellular process 
                 62 
                 3.31E−05 
                 1.67486297 
                 0.00139553 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050789~regulation of biological process 
                 162 
                 3.82E−05 
                 1.2502125 
                 0.00158231 
               
               
                 GOTERM_BP_ALL 
                 GO: 0010033~response to organic substance 
                 31 
                 4.31E−05 
                 2.24600094 
                 0.00171764 
               
               
                 GOTERM_BP_ALL 
                 GO: 0008284~positive regulation of cell proliferation 
                 21 
                 4.26E−05 
                 2.85513777 
                 0.00172889 
               
               
                 GOTERM_BP_ALL 
                 GO: 0045765~regulation of angiogenesis 
                 8 
                 4.56E−05 
                 8.00921765 
                 0.00178429 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050867~positive regulation of cell activation 
                 11 
                 4.77E−05 
                 5.11856691 
                 0.00183348 
               
               
                 GOTERM_CC_ALL 
                 GO: 0005578~proteinaceous extracellular matrix 
                 12 
                 0.0001102 
                 4.24643494 
                 0.00196599 
               
               
                 GOTERM_CC_ALL 
                 GO: 0031982~vesicle 
                 28 
                 0.00012722 
                 2.234456653 
                 0.00211822 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048869~cellular developmental process 
                 50 
                 5.94E−05 
                 1.77814977 
                 0.00220286 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048545~response to steroid hormone stimulus 
                 13 
                 5.85E−05 
                 4.16984754 
                 0.00220693 
               
               
                 GOTERM_BP_ALL 
                 GO: 0051094~positive regulation of developmental process 
                 17 
                 6.39E−05 
                 3.24651091 
                 0.00232928 
               
               
                 GOTERM_BP_ALL 
                 GO: 0032879~regulation of localization 
                 25 
                 0.00010654 
                 2.4010191 
                 0.00381602 
               
               
                 GOTERM_CC_ALL 
                 GO: 0016023~cytoplasmic membrane-bounded vesicle 
                 24 
                 0.0002448 
                 2.32906958 
                 0.00381824 
               
               
                 KEGG_PATHWAY 
                 hsa04640: Hematopoietic cell lineage 
                 9 
                 8.02E−05 
                 6.02036055 
                 0.00408452 
               
               
                 GOTERM_CC_ALL 
                 GO: 0009897~external side of plasma membrane 
                 10 
                 0.00031648 
                 4.54973171 
                 0.00464398 
               
               
                 GOTERM_CC_ALL 
                 GO: 0031988~membrane-bounded vesicle 
                 24 
                 0.00039301 
                 2.25413972 
                 0.00490148 
               
               
                 GOTERM_CC_ALL 
                 GO: 0030141~secretory granule 
                 11 
                 0.00038339 
                 4.01420803 
                 0.00503284 
               
               
                 GOTERM_CC_ALL 
                 GO: 0031410~cytoplasmic vesicle 
                 26 
                 0.00037285 
                 2.16871498 
                 0.00516605 
               
               
                 GOTERM_BP_ALL 
                 GO: 0015718~monocarboxylic acid transport 
                 7 
                 0.00015289 
                 8.2595057 
                 0.00538215 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048523~negative regulation of cellular process 
                 56 
                 0.00015724 
                 1.64309882 
                 0.00544596 
               
               
                 GOTERM_BP_ALL 
                 GO: 0002696~positive regulation of leukocyte activation 
                 10 
                 0.00016618 
                 4.93104818 
                 0.00566357 
               
               
                 GOTERM_BP_ALL 
                 GO: 0002694~regulation of leukocyte activation 
                 12 
                 0.00018259 
                 4.00460883 
                 0.00612434 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050864~regulation of B cell activation 
                 7 
                 0.00018795 
                 7.97469516 
                 0.00620684 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050871~positive regulation of B cell activation 
                 6 
                 0.00019715 
                 10.4330598 
                 0.00641133 
               
               
                 GOTERM_BP_ALL 
                 GO: 0042981~regulation of apoptosis 
                 35 
                 0.00020205 
                 1.94996762 
                 0.00647234 
               
               
                 GOTERM_BP_ALL 
                 GO: 0051240~positive regulation of multicellular organismal process 
                 14 
                 0.00020826 
                 3.42616532 
                 0.00657273 
               
               
                 GOTERM_BP_ALL 
                 GO: 0007186~G-protein coupled receptor protein signaling pathway 
                 19 
                 0.00021787 
                 2.70570014 
                 0.00677572 
               
               
                 GOTERM_BP_ALL 
                 GO: 0030890~positive regulation of B cell proliferation 
                 5 
                 0.00022555 
                 15.0172831 
                 0.00691393 
               
               
                 GOTERM_BP_ALL 
                 GO: 0043067~regulation of programmed cell death 
                 35 
                 0.00024393 
                 1.93043539 
                 0.00737064 
               
               
                 GOTERM_BP_ALL 
                 GO: 0051704~multi-organism process 
                 28 
                 0.00024768 
                 2.14135333 
                 0.00737981 
               
               
                 GOTERM_BP_ALL 
                 GO: 0080134~regulation of response to stress 
                 16 
                 0.00025225 
                 3.02061929 
                 0.00741299 
               
               
                 GOTERM_BP_ALL 
                 GO: 0009653~anatomical structure morphogenesis 
                 38 
                 0.00025614 
                 1.85991832 
                 0.00742555 
               
               
                 GOTERM_BP_ALL 
                 GO: 0010941~regulation of cell death 
                 35 
                 0.00026015 
                 1.92401131 
                 0.00744133 
               
               
                 GOTERM_BP_ALL 
                 GO: 0045087~innate immune response 
                 10 
                 0.00029011 
                 4.58861428 
                 0.00808025 
               
               
                 GOTERM_BP_ALL 
                 GO: 0001501~skeletal system development 
                 15 
                 0.00028723 
                 3.13652115 
                 0.00810512 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050794~regulation of cellular process 
                 153 
                 0.00029774 
                 1.22749332 
                 0.00818597 
               
               
                 GOTERM_BP_ALL 
                 GO: 0007155~cell adhesion 
                 23 
                 0.00035599 
                 2.31669062 
                 0.0096566 
               
               
                 GOTERM_BP_ALL 
                 GO: 0022610~biological adhesion 
                 23 
                 0.0003765 
                 2.30964901 
                 0.01008332 
               
               
                 GOTERM_BP_ALL 
                 GO: 0002706~regulation of lymphocyte mediated immunity 
                 7 
                 0.00039607 
                 7.00806545 
                 0.01047439 
               
               
                 GOTERM_BP_ALL 
                 GO: 0002697~regulation of immune effector process 
                 9 
                 0.00040369 
                 4.95570342 
                 0.01054539 
               
               
                 GOTERM_BP_ALL 
                 GO: 0032680~regulation of tumor necrosis factor production 
                 6 
                 0.00041457 
                 9.01036985 
                 0.0106985 
               
               
                 GOTERM_BP_ALL 
                 GO: 0051270~regulation of cell motion 
                 13 
                 0.00043338 
                 3.38184485 
                 0.01104886 
               
               
                 GOTERM_BP_ALL 
                 GO: 0009607~response to biotic stimulus 
                 18 
                 0.00048671 
                 2.61975511 
                 0.01225545 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048878~chemical homeostasis 
                 19 
                 0.00051554 
                 2.52097362 
                 0.01282688 
               
               
                 GOTERM_BP_ALL 
                 GO: 0051241~negative regulation of multicellular organismal process 
                 10 
                 0.00053115 
                 4.23564395 
                 0.01306189 
               
               
                 GOTERM_BP_ALL 
                 GO: 0031099~regeneration 
                 7 
                 0.00055185 
                 6.60760456 
                 0.01341453 
               
               
                 GOTERM_BP_ALL 
                 GO: 0001503~ossification 
                 9 
                 0.00056526 
                 4.71971754 
                 0.01358496 
               
               
                 GOTERM_BP_ALL 
                 GO: 0007596~blood coagulation 
                 8 
                 0.00060782 
                 5.39396291 
                 0.01443964 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050817~coagulation 
                 8 
                 0.00060782 
                 5.39396291 
                 0.01443964 
               
               
                 GOTERM_BP_ALL 
                 GO: 0051251~positive regulation of lymphocyte activation 
                 9 
                 0.00062947 
                 4.64597198 
                 0.01478703 
               
               
                 GOTERM_BP_ALL 
                 GO: 0030193~regulation of blood coagulation 
                 5 
                 0.00063688 
                 11.7992938 
                 0.01479853 
               
               
                 GOTERM_BP_ALL 
                 GO: 0046903~secretion 
                 14 
                 0.00066151 
                 3.04297579 
                 0.01520272 
               
               
                 GOTERM_BP_ALL 
                 GO: 0060348~bone development 
                 9 
                 0.00069943 
                 4.57449547 
                 0.0158979 
               
               
                 GOTERM_BP_ALL 
                 GO: 0002700~regulation of production of molecular mediator of 
                 6 
                 0.00077675 
                 7.92912548 
                 0.01745622 
               
               
                   
                 immune response 
                   
                   
                   
                   
               
               
                 GOTERM_BP_ALL 
                 GO: 0030888~regulation of B cell proliferation 
                 5 
                 0.00084803 
                 11.0126743 
                 0.01846594 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050778~positive regulation of immune response 
                 10 
                 0.00083992 
                 3.98048468 
                 0.01847785 
               
               
                 GOTERM_BP_ALL 
                 GO: 0010876~lipid localization 
                 11 
                 0.00083164 
                 3.63418251 
                 0.01848608 
               
               
                 GOTERM_BP_ALL 
                 GO: 0001819~positive regulation of cytokine production 
                 9 
                 0.00085816 
                 4.43794336 
                 0.01849764 
               
               
                 GOTERM_BP_ALL 
                 GO: 0032103~positive regulation of response to external stimulus 
                 7 
                 0.0008702 
                 6.08595157 
                 0.01856902 
               
               
                 GOTERM_BP_ALL 
                 GO: 0007610~behavior 
                 17 
                 0.00088888 
                 2.57635958 
                 0.01877795 
               
               
                 GOTERM_BP_ALL 
                 GO: 0051179~localization 
                 80 
                 0.00090886 
                 1.39180717 
                 0.01900988 
               
               
                 GOTERM_CC_ALL 
                 GO: 0031091~platelet alpha granule 
                 6 
                 0.0016609 
                 6.78059772 
                 0.01959452 
               
               
                 GOTERM_BP_ALL 
                 GO: 0009615~response to virus 
                 9 
                 0.00094771 
                 4.37267949 
                 0.01962413 
               
               
                 GOTERM_BP_ALL 
                 GO: 0043065~positive regulation of apoptosis 
                 22 
                 0.00097104 
                 2.20253485 
                 0.01972357 
               
               
                 GOTERM_BP_ALL 
                 GO: 0001817~regulation of cytokine production 
                 12 
                 0.00096317 
                 3.30380228 
                 0.01975149 
               
               
                 GOTERM_BP_ALL 
                 GO: 0015849~organic acid transport 
                 10 
                 0.00099852 
                 3.88682621 
                 0.02008682 
               
               
                 GOTERM_BP_ALL 
                 GO: 0046942~carboxylic acid transport 
                 10 
                 0.00099852 
                 3.88682621 
                 0.02008682 
               
               
                 GOTERM_BP_ALL 
                 GO: 0007167~enzyme linked receptor protein signaling pathway 
                 16 
                 0.00103032 
                 2.64304183 
                 0.02052865 
               
               
                 GOTERM_BP_ALL 
                 GO: 0043068~positive regulation of programmed cell death 
                 22 
                 0.00104554 
                 2.18926657 
                 0.02063801 
               
               
                 GOTERM_BP_ALL 
                 GO: 0010942~positive regulation of cell death 
                 22 
                 0.0010885 
                 2.1826922 
                 0.02128235 
               
               
                 GOTERM_BP_ALL 
                 GO: 0007599~hemostasis 
                 8 
                 0.00110252 
                 4.8945219 
                 0.02135976 
               
               
                 GOTERM_CC_ALL 
                 GO: 0005604~basement membrane 
                 6 
                 0.00192342 
                 6.56870404 
                 0.02164046 
               
               
                 GOTERM_MF_ALL 
                 GO: 0004930~G-protein coupled receptor activity 
                 13 
                 0.00026195 
                 3.57735882 
                 0.02172968 
               
               
                 GOTERM_BP_ALL 
                 GO: 0045597~positive regulation of cell differentiation 
                 13 
                 0.00125057 
                 3.00345662 
                 0.02397951 
               
               
                 GOTERM_MF_ALL 
                 GO: 0004896~cytokine receptor activity 
                 7 
                 0.00025702 
                 7.58468866 
                 0.02483432 
               
               
                 GOTERM_BP_ALL 
                 GO: 0051249~regulation of lymphocyte activation 
                 10 
                 0.00150309 
                 3.67089142 
                 0.02825331 
               
               
                 GOTERM_BP_ALL 
                 GO: 0007179~transforming growth factor beta receptor signaling 
                 7 
                 0.00149516 
                 5.50633714 
                 0.0283535 
               
               
                   
                 pathway 
                   
                   
                   
                   
               
               
                 GOTERM_BP_ALL 
                 GO: 0043627~response to estrogen stimulus 
                 8 
                 0.00152438 
                 4.63691548 
                 0.02840023 
               
               
                 GOTERM_BP_ALL 
                 GO: 0009888~tissue development 
                 21 
                 0.00154092 
                 2.17491686 
                 0.02845818 
               
               
                 GOTERM_MF_ALL 
                 GO: 0001871~pattern binding 
                 9 
                 0.00041201 
                 4.95326606 
                 0.02978498 
               
               
                 GOTERM_MF_ALL 
                 GO: 0030247~polysaccharide binding 
                 9 
                 0.00041201 
                 4.95326606 
                 0.02978498 
               
               
                 GOTERM_BP_ALL 
                 GO: 0006869~lipid transport 
                 10 
                 0.00175493 
                 3.59108944 
                 0.03207509 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050818~regulation of coagulation 
                 5 
                 0.00177021 
                 9.17722856 
                 0.03207792 
               
               
                 GOTERM_BP_ALL 
                 GO: 0032946~positive regulation of mononuclear cell proliferation 
                 6 
                 0.00184227 
                 6.60760456 
                 0.03308502 
               
               
                 GOTERM_BP_ALL 
                 GO: 0070665~positive regulation of leukocyte proliferation 
                 6 
                 0.00184227 
                 6.60760456 
                 0.03308502 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050671~positive regulation of lymphocyte proliferation 
                 6 
                 0.00184227 
                 6.60760456 
                 0.03308502 
               
               
                 GOTERM_BP_ALL 
                 GO: 0002526~acute inflammatory response 
                 7 
                 0.00191336 
                 5.25604908 
                 0.03405697 
               
               
                 GOTERM_BP_ALL 
                 GO: 0043066~negative regulation of apoptosis 
                 18 
                 0.0020912 
                 2.29607881 
                 0.0365633 
               
               
                 GOTERM_BP_ALL 
                 GO: 0042592~homeostatic process 
                 25 
                 0.00207425 
                 1.95260182 
                 0.03656882 
               
               
                 GOTERM_BP_ALL 
                 GO: 0007204~elevation of cytosolic calcium ion concentration 
                 7 
                 0.00215298 
                 5.13924799 
                 0.03732145 
               
               
                 KEGG_PATHWAY 
                 hsa04610: Complement and coagulation cascades 
                 6 
                 0.00112812 
                 7.15463138 
                 0.0376508 
               
               
                 GOTERM_BP_ALL 
                 GO: 0009617~response to bacterium 
                 10 
                 0.00219498 
                 3.47768661 
                 0.03773294 
               
               
                 GOTERM_BP_ALL 
                 GO: 0043069~negative regulation of programmed cell death 
                 18 
                 0.00237947 
                 2.26978783 
                 0.04051986 
               
               
                 GOTERM_BP_ALL 
                 GO: 0009725~response to hormone stimulus 
                 16 
                 0.00241757 
                 2.42480901 
                 0.04083361 
               
               
                 GOTERM_BP_ALL 
                 GO: 0031328~positive regulation of cellular biosynthetic process 
                 25 
                 0.00244022 
                 1.92979105 
                 0.04088828 
               
               
                 GOTERM_BP_ALL 
                 GO: 0060548~negative regulation of cell death 
                 18 
                 0.00248193 
                 2.26115745 
                 0.04125275 
               
               
                 GOTERM_MF_ALL 
                 GO: 0030246~carbohydrate binding 
                 14 
                 0.00073273 
                 3.01503152 
                 0.0421143 
               
               
                 GOTERM_CC_ALL 
                 GO: 0000267~cell fraction 
                 32 
                 0.00404178 
                 1.69344233 
                 0.04306656 
               
               
                 GOTERM_MF_ALL 
                 GO: 0019899~enzyme binding 
                 25 
                 0.0008491 
                 2.08872665 
                 0.04431816 
               
               
                 GOTERM_MF_ALL 
                 GO: 0001608~nucleotide receptor activity, G-protein coupled 
                 5 
                 0.00070835 
                 11.5576208 
                 0.04516455 
               
               
                 GOTERM_MF_ALL 
                 GO: 0045028~purinergic nucleotide receptor activity, G-protein coupled 
                 5 
                 0.00070835 
                 11.5576208 
                 0.04516455 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050801~ion homeostasis 
                 15 
                 0.00286437 
                 2.47785171 
                 0.04710319 
               
               
                 GOTERM_BP_ALL 
                 GO: 0003008~system process 
                 26 
                 0.00293122 
                 1.87143484 
                 0.04745392 
               
               
                 GOTERM_BP_ALL 
                 GO: 0040012~regulation of locomotion 
                 11 
                 0.00291736 
                 3.07981569 
                 0.04759185 
               
               
                 GOTERM_BP_ALL 
                 GO: 0031349~positive regulation of defense response 
                 7 
                 0.00300863 
                 4.81804499 
                 0.04831554 
               
               
                 GOTERM_BP_ALL 
                 GO: 0009891~positive regulation of biosynthetic process 
                 25 
                 0.00310955 
                 1.89438204 
                 0.04916602 
               
               
                 GOTERM_BP_ALL 
                 GO: 0009966~regulation of signal transduction 
                 31 
                 0.00313297 
                 1.73884331 
                 0.04916714 
               
               
                 GOTERM_BP_ALL 
                 GO: 0060341~regulation of cellular localization 
                 11 
                 0.00310259 
                 3.05393488 
                 0.04942072 
               
               
                   
               
             
          
         
       
     
         [0419]    Among the top probesets downregulated by Copaxone with FC≦1.3, six pathways were enriched. This includes developmental processes (as also seen in prior studies e.g. FDA-2014-P-0933-0001 available at www.regulations.gov/#!documentDetail;D=FDA-2014-P-0933-0001, and also described herein), and cell-cell adhesion related pathways. 
         [0420]    The top 25 pathways enriched among top upregulated probesets are shown in Table 25, and  FIG. 35  illustrates pathways enriched among top probesets differentially modulated by Copaxone® (|FC|≧1.3, FDR p&lt;0.05). As an example of an enriched pathway anticipated to be relevant to Copaxone® mechanism of action, cytokine-cytokine receptor interaction, the individual genes modulated by Copaxone® involved in this pathway are depicted in  FIG. 36 . 
         [0000]    
       
         
               
             
               
               
               
               
             
               
               
               
               
             
           
               
                 TABLE 25 
               
             
             
               
                   
               
               
                 Top Pathways enriched among top probesets upregulated by 
               
               
                 Copaxone ® 
               
             
          
           
               
                 Category 
                 Term 
                 Count a   
                 Adjusted P value 
               
               
                   
               
             
          
           
               
                 GO Cellular 
                 GO: 0005886~plasma membrane 
                 122 
                 5.85E−23 
               
               
                 Compartment 
                   
                   
                   
               
               
                 GO Cellular 
                 GO: 0031226~intrinsic to plasma 
                 58 
                 8.04E−17 
               
               
                 Compartment 
                 membrane 
                   
                   
               
               
                 GO Biological Process 
                 GO: 0009611~response to wounding 
                 44 
                 2.16E−16 
               
               
                 GO Biological Process 
                 GO: 0009605~response to external 
                 58 
                 2.34E−16 
               
               
                   
                 stimulus 
                   
                   
               
               
                 GO Biological Process 
                 GO: 0050896~response to stimulus 
                 118 
                 4.45E−16 
               
               
                 GO Cellular 
                 GO: 0005887~integral to plasma 
                 56 
                 6.29E−16 
               
               
                 Compartment 
                 membrane 
                   
                   
               
               
                 GO Biological Process 
                 GO: 0006955~immune response 
                 46 
                 4.79E−14 
               
               
                 GO Biological Process 
                 GO: 0002376~immune system process 
                 59 
                 5.97E−14 
               
               
                 GO Cellular 
                 GO: 0016020~membrane 
                 174 
                 6.33E−13 
               
               
                 Compartment 
                   
                   
                   
               
               
                 GO Cellular 
                 GO: 0005576~extracellular region 
                 58 
                 6.45E−13 
               
               
                 Compartment 
                   
                   
                   
               
               
                 GO Biological Process 
                 GO: 0006952~defense response 
                 40 
                 3.86E−12 
               
               
                 GO Cellular 
                 GO: 0044459~plasma membrane part 
                 76 
                 4.00E−12 
               
               
                 Compartment 
                   
                   
                   
               
               
                 GO Molecular Function 
                 GO: 0004888~transmembrane receptor 
                 39 
                 8.19E−12 
               
               
                   
                 activity 
                   
                   
               
               
                 GO Molecular Function 
                 GO: 0060089~molecular transducer 
                 69 
                 1.15E−11 
               
               
                   
                 activity 
                   
                   
               
               
                 GO Molecular Function 
                 GO: 0004871~signal transducer activity 
                 69 
                 1.15E−11 
               
               
                 GO Molecular Function 
                 GO: 0004872~receptor activity 
                 56 
                 2.05E−11 
               
               
                 GO Cellular 
                 GO: 0044421~extracellular region part 
                 37 
                 5.16E−11 
               
               
                 Compartment 
                   
                   
                   
               
               
                 GO Biological Process 
                 GO: 0006954~inflammatory response 
                 28 
                 3.57E−10 
               
               
                 GO Cellular 
                 GO: 0031224~intrinsic to membrane 
                 125 
                 3.08E−09 
               
               
                 Compartment 
                   
                   
                   
               
               
                 GO Cellular 
                 GO: 0016021~integral to membrane 
                 121 
                 8.31E−09 
               
               
                 Compartment 
                   
                   
                   
               
               
                 GO Cellular 
                 GO: 0044425~membrane part 
                 146 
                 3.43E−08 
               
               
                 Compartment 
                   
                   
                   
               
               
                 Kegg Pathway 
                 hsa04060: Cytokine-cytokine receptor 
                 21 
                 5.00E−08 
               
               
                   
                 interaction 
                   
                   
               
               
                 GO Cellular 
                 GO: 0005615~extracellular space 
                 27 
                 5.72E−08 
               
               
                 Compartment 
                   
                   
                   
               
               
                 GO Biological Process 
                 GO: 0006950~response to stress 
                 70 
                 1.44E−07 
               
               
                 GO Biological Process 
                 GO: 0042060~wound healing 
                 19 
                 1.90E−07 
               
               
                   
               
               
                   a Count refers to number of genes within the list of interest annotated to the pathway. 
               
               
                 GO database: Ashburner, M. et al. Gene ontology: tool for the unification of biology. The Gene Ontology Consortium.  Nat. Genet.  25, 25-29 (2000). 
               
               
                 Kegg database: Kanehisa, M. &amp; Goto, S. KEGG: kyoto encyclopedia of genes and genomes.  Nucleic Acids Res.  28, 27-30 (2000). 
               
               
                 Copaxone MoA discussion 
               
             
          
         
       
     
         [0421]    The fact that 12,115 probesets are significantly modulated by Copaxone relative to mannitol provides a window into the complexity of Copaxone®&#39;s mechanism of action on antigen-presenting cells. Despite the complexity and scope of this modulation, key genes known to be modulated by Copaxone® (such as IL1RN, IL1ORA) appear in the expected directionality. These modulated genes are significantly enriched in immunology-related pathways which are known to be relevant for Copaxone&#39;s mechanism of action. These two aspects combined together validate the design of the study and its ability to identify relevant aspects of a medicine&#39;s interaction with antigen-presenting cells. 
       Polimunol and Copaxone® Comparison: Differentially Expressed Genes 
       [0422]    Comparison of Polimunol versus Copaxone® treatment, corrected for Mannitol control expression [i.e. (Polimunol-Mannitol)-(Copaxone-Mannitol)], resulted in 807 probesets differentially expressed with FDR-adjusted p&lt;0.05. Upon filtering for “present” calls only, 518 upregulated probesets and 289 downregulated probesets were detected. 
         [0423]    After conservative filtering out of highly variable probesets (i.e. the few previously identified to have differing behavior between THP-1 studies, which removed 3.5% of the 807 probesets), 779 modulated probesets persist: 494 upregulated probesets and 285 downregulated probesets. After these filtering steps, the top 25 upregulated probesets are shown in Table 26, and the top 25 downregulated probesets are shown in Table 27. 
         [0000]    
       
         
               
             
               
               
               
               
               
             
           
               
                 TABLE 26 
               
             
             
               
                   
               
               
                 Probesets significantly upregulated in Polimunol versus 
               
               
                 Copaxone ® 
               
             
          
           
               
                 Probeset 
                 Gene 
                 raw.FC 
                 P.Value 
                 adj.P.Value 
               
               
                   
               
               
                 212665_at 
                 TIPARP 
                 1.18 
                 2.68E−17 
                 1.47E−12 
               
               
                 202436_s_at 
                 CYP1B1 
                 1.41 
                 1.64E−15 
                 4.49E−11 
               
               
                 224735_at 
                 CYBASC3 
                 1.16 
                 3.50E−14 
                 6.37E−10 
               
               
                 209921_at 
                 SLC7A11 
                 1.35 
                 2.57E−13 
                 3.51E−09 
               
               
                 202435_s_at 
                 CYP1B1 
                 1.37 
                 3.31E−13 
                 3.62E−09 
               
               
                 208937_s_at 
                 ID1 
                 1.22 
                 1.03E−12 
                 9.43E−09 
               
               
                 202434_s_at 
                 CYP1B1 
                 1.42 
                 2.03E−12 
                 1.58E−08 
               
               
                 228964_at 
                 PRDM1 
                 1.24 
                 3.29E−12 
                 2.07E−08 
               
               
                 223113_at 
                 TMEM138 
                 1.11 
                 3.40E−12 
                 2.07E−08 
               
               
                 230966_at 
                 IL4I1 
                 1.33 
                 1.60E−11 
                 8.74E−08 
               
               
                 202014_at 
                 PPP1R15A 
                 1.24 
                 1.86E−11 
                 9.24E−08 
               
               
                 202437_s_at 
                 CYP1B1 
                 1.34 
                 2.45E−11 
                 1.06E−07 
               
               
                 37028_at 
                 PPP1R15A 
                 1.19 
                 2.52E−11 
                 1.06E−07 
               
               
                 39402_at 
                 IL1B 
                 1.23 
                 3.09E−11 
                 1.21E−07 
               
               
                 205067_at 
                 IL1B 
                 1.28 
                 4.02E−11 
                 1.47E−07 
               
               
                 217678_at 
                 SLC7A11 
                 1.29 
                 6.91E−11 
                 2.36E−07 
               
               
                 216598_s_at 
                 CCL2 
                 1.35 
                 8.57E−11 
                 2.67E−07 
               
               
                 203821_at 
                 HBEGF 
                 1.24 
                 8.80E−11 
                 2.67E−07 
               
               
                 201468_s_at 
                 NQO1 
                 1.16 
                 9.34E−11 
                 2.69E−07 
               
               
                 225252_at 
                 SRXN1 
                 1.12 
                 1.12E−10 
                 3.07E−07 
               
               
                 211307_s_at 
                 FCAR 
                 1.27 
                 1.31E−10 
                 3.41E−07 
               
               
                 209928_s_at 
                 MSC 
                 1.19 
                 1.40E−10 
                 3.48E−07 
               
               
                 201266_at 
                 TXNRD1 
                 1.07 
                 2.22E−10 
                 5.28E−07 
               
               
                 210519_s_at 
                 NQO1 
                 1.14 
                 3.76E−10 
                 8.22E−07 
               
               
                 212171_x_at 
                 VEGF 
                 1.14 
                 1.22E−09 
                 2.46E−06 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
               
               
             
           
               
                 TABLE 27 
               
             
             
               
                   
               
               
                 Probesets significantly downregulated in Polimunol versus 
               
               
                 Copaxone ® 
               
             
          
           
               
                 Probeset 
                 Gene 
                 raw.FC 
                 P.Value 
                 adj.P.Val. 
               
               
                   
               
               
                 204614_at 
                 SERPINB2 
                 −1.16 
                 4.60E−10 
                 9.68E−07 
               
               
                 211421_s_at 
                 RET 
                 −1.13 
                 1.75E−09 
                 3.41E−06 
               
               
                 207725_at 
                 POU4F2 
                 −1.16 
                 3.49E−09 
                 6.15E−06 
               
               
                 208206_s_at 
                 RASGRP2 
                 −1.11 
                 1.56E−08 
                 1.82E−05 
               
               
                 218971_s_at 
                 HSPC049 
                 −1.15 
                 3.32E−08 
                 3.04E−05 
               
               
                 222799_at 
                 HSPC049 
                 −1.17 
                 5.13E−08 
                 4.25E−05 
               
               
                 219463_at 
                 C20ORF103 
                 −1.11 
                 6.49E−08 
                 5.22E−05 
               
               
                 218858_at 
                 DEPDC6 
                 −1.17 
                 8.64E−08 
                 6.72E−05 
               
               
                 214539_at 
                 SERPINB10 
                 −1.14 
                 1.06E−07 
                 7.91E−05 
               
               
                 225510_at 
                 OAF 
                 −1.08 
                 1.88E−07 
                 0.000121086 
               
               
                 228855_at 
                 LOC645919 
                 −1.13 
                 2.00E−07 
                 0.000125905 
               
               
                 200799_at 
                 HSPA1A 
                 −1.09 
                 2.92E−07 
                 0.000168544 
               
               
                 206643_at 
                 HAL 
                 −1.11 
                 3.17E−07 
                 0.000176999 
               
               
                 44790_s_at 
                 C13ORF18 
                 −1.11 
                 3.23E−07 
                 0.000178591 
               
               
                 202441_at 
                 SPFH1 
                 −1.09 
                 5.23E−07 
                 0.000255211 
               
               
                 206034_at 
                 SERPINB8 
                 −1.08 
                 7.06E−07 
                 0.000321557 
               
               
                 203685_at 
                 BCL2 
                 −1.16 
                 7.53E−07 
                 0.000340412 
               
               
                 216733_s_at 
                 GATM 
                 −1.09 
                 8.49E−07 
                 0.000374363 
               
               
                 224428_s_at 
                 CDCA7 
                 −1.07 
                 8.91E−07 
                 0.000386704 
               
               
                 201310_s_at 
                 C5ORF13 
                 −1.11 
                 1.13E−06 
                 0.000455961 
               
               
                 213361_at 
                 TDRD7 
                 −1.16 
                 1.28E−06 
                 0.000504959 
               
               
                 219714_s_at 
                 CACNA2D3 
                 −1.09 
                 1.40E−06 
                 0.000542581 
               
               
                 35974_at 
                 LRMP 
                 −1.12 
                 1.69E−06 
                 0.000628259 
               
               
                 201309_x_at 
                 C5ORF13 
                 −1.12 
                 1.96E−06 
                 0.000705871 
               
               
                 243824_at 
                 — 
                 −1.18 
                 2.13E−06 
                 0.000730854 
               
               
                   
               
             
          
         
       
     
         [0424]    As observed in the earlier study of the same design (FDA-2014-P-0933-0001 available at www.regulations.gov/#?documentDetail;D=FDA-2014-P-0933-0001, and also described herein), Polimunol consistently upregulated CYP1B1 relative to Copaxone® (all four probesets on chip: FDR p values 4.5e-11, 3.6e-9, 1.6e-8, 1.1e-7, See  FIG. 37 ). 
         [0425]    However, ADRB2 was not significantly downregulated by Polimunol relative to Copaxone® in the second set of studies (FC −1.06, nominal p 0.06). 
         [0426]    The probesets significantly differentially expressed between Polimunol and Copaxone® treatment (corrected for mannitol control) in THP-1 cells is provided in Table 28. 
         [0000]    
       
         
               
             
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
             
           
               
                 TABLE 28 
               
             
             
               
                   
               
               
                 Probesets significantly differentially expressed between Polimunol and Copaxone ® treatment 
               
               
                 (corrected for mannitol control) in THP-1 cells. 
               
             
          
           
               
                 Probeset 
                 Gene 
                 raw. FC 
                 AveExpr 
                 t 
                 P. Value 
                 adj. P. Val 
                 B 
               
               
                   
               
             
          
           
               
                 212665_at 
                 TIPARP 
                 1.18491814 
                 9.07215527 
                 11.883114 
                 2.68E−17 
                 1.47E−12 
                 27.6284062 
               
               
                 202436_s_at 
                 CYP1B1 
                 1.40629663 
                 10.5046627 
                 10.7394789 
                 1.64E−15 
                 4.49E−11 
                 23.9781074 
               
               
                 224735_at 
                 CYBASC3 
                 1.16280829 
                 11.1371084 
                 9.91592252 
                 3.50E−14 
                 6.37E−10 
                 21.2319004 
               
               
                 209921_at 
                 SLC7A11 
                 1.34875797 
                 8.01938606 
                 9.38858221 
                 2.57E−13 
                 3.51E−09 
                 19.4266298 
               
               
                 202435_s_at 
                 CYP1B1 
                 1.36824479 
                 10.7674593 
                 9.32190062 
                 3.31E−13 
                 3.62E−09 
                 19.1959747 
               
               
                 208937_s_at 
                 ID1 
                 1.21578992 
                 9.79600279 
                 9.02417027 
                 1.03E−12 
                 9.43E−09 
                 18.1600689 
               
               
                 202434_s_at 
                 CYP1B1 
                 1.42360365 
                 8.59154176 
                 8.84918014 
                 2.03E−12 
                 1.58E−08 
                 17.5468656 
               
               
                 228964_at 
                 PRDM1 
                 1.24239601 
                 8.33311381 
                 8.72349013 
                 3.29E−12 
                 2.07E−08 
                 17.1045709 
               
               
                 223113_at 
                 TMEM138 
                 1.1063561 
                 11.1028453 
                 8.71472552 
                 3.40E−12 
                 2.07E−08 
                 17.0736735 
               
               
                 230966_at 
                 IL4I1 
                 1.32516688 
                 8.36704038 
                 8.31508719 
                 1.60E−11 
                 8.74E−08 
                 15.657823 
               
               
                 202014_at 
                 PPP1R15A 
                 1.23664454 
                 8.57467088 
                 8.27614067 
                 1.86E−11 
                 9.24E−08 
                 15.5191648 
               
               
                 202437_s_at 
                 CYP1B1 
                 1.34228274 
                 11.0857103 
                 8.20543116 
                 2.45E−11 
                 1.06E−07 
                 15.2671479 
               
               
                 37028_at 
                 PPP1R15A 
                 1.18998338 
                 9.10953004 
                 8.19801576 
                 2.52E−11 
                 1.06E−07 
                 15.2406986 
               
               
                 39402_at 
                 IL1B 
                 1.22916144 
                 8.58599227 
                 8.14511174 
                 3.09E−11 
                 1.21E−07 
                 15.0518933 
               
               
                 205067_at 
                 IL1B 
                 1.27678411 
                 8.78154185 
                 8.0777594 
                 4.02E−11 
                 1.47E−07 
                 14.8112634 
               
               
                 217678_at 
                 SLC7A11 
                 1.28685305 
                 7.69726333 
                 7.93874264 
                 6.91E−11 
                 2.36E−07 
                 14.3137409 
               
               
                 216598_s_at 
                 CCL2 
                 1.34792469 
                 9.28596162 
                 7.88363055 
                 8.57E−11 
                 2.67E−07 
                 14.116209 
               
               
                 203821_at 
                 HBEGF 
                 1.23590003 
                 9.26713046 
                 7.87666898 
                 8.80E−11 
                 2.67E−07 
                 14.0912465 
               
               
                 201468_s_at 
                 NQO1 
                 1.15576656 
                 9.35668628 
                 7.86152927 
                 9.34E−11 
                 2.69E−07 
                 14.0369508 
               
               
                 225252_at 
                 SRXN1 
                 1.11737221 
                 9.70265778 
                 7.81446478 
                 1.12E−10 
                 3.07E−07 
                 13.8680929 
               
               
                 211307_s_at 
                 FCAR 
                 1.27074012 
                 7.1312048 
                 7.77503632 
                 1.31E−10 
                 3.41E−07 
                 13.7265534 
               
               
                 209928_s_at 
                 MSC 
                 1.18769631 
                 8.08116641 
                 7.75739241 
                 1.40E−10 
                 3.48E−07 
                 13.6631936 
               
               
                 201266_at 
                 TXNRD1 
                 1.06947321 
                 11.9113637 
                 7.6396293 
                 2.22E−10 
                 5.28E−07 
                 13.239984 
               
               
                 210519_s_at 
                 NQO1 
                 1.13794807 
                 10.6816859 
                 7.50492043 
                 3.76E−10 
                 8.22E−07 
                 12.7552954 
               
               
                 212171_x_at 
                 VEGF 
                 1.13674051 
                 9.43661194 
                 7.20421256 
                 1.22E−09 
                 2.46E−06 
                 11.6719358 
               
               
                 38037_at 
                 HBEGF 
                 1.18482724 
                 7.98711019 
                 7.0523034 
                 2.20E−09 
                 4.14E−06 
                 11.1244167 
               
               
                 201118_at 
                 PGD 
                 1.07758185 
                 12.4845488 
                 6.97857101 
                 2.93E−09 
                 5.34E−06 
                 10.8587242 
               
               
                 203045_at 
                 NINJ1 
                 1.12384597 
                 9.41715175 
                 6.88585707 
                 4.21E−09 
                 7.19E−06 
                 10.5247541 
               
               
                 216250_s_at 
                 LPXN 
                 1.24070246 
                 10.2461732 
                 6.84611362 
                 4.91E−09 
                 7.90E−06 
                 10.3816492 
               
               
                 210512_s_at 
                 VEGF 
                 1.17453419 
                 10.5171208 
                 6.84606411 
                 4.91E−09 
                 7.90E−06 
                 10.3814709 
               
               
                 210592_s_at 
                 SAT1 
                 1.14616249 
                 9.85711211 
                 6.78833303 
                 6.15E−09 
                 9.16E−06 
                 10.1736745 
               
               
                 210095_s_at 
                 IGFBP3 
                 1.26126777 
                 7.77688369 
                 6.7861051 
                 6.20E−09 
                 9.16E−06 
                 10.1656573 
               
               
                 208893_s_at 
                 DUSP6 
                 1.23681965 
                 10.7702231 
                 6.7782857 
                 6.39E−09 
                 9.20E−06 
                 10.1375206 
               
               
                 202284_s_at 
                 CDKN1A 
                 1.12078798 
                 10.6198443 
                 6.75691033 
                 6.95E−09 
                 9.69E−06 
                 10.0606157 
               
               
                 209122_at 
                 ADFP 
                 1.14098228 
                 12.3228398 
                 6.75171809 
                 7.09E−09 
                 9.69E−06 
                 10.0419373 
               
               
                 228937_at 
                 C13ORF31 
                 1.17921905 
                 8.37907051 
                 6.70099976 
                 8.63E−09 
                 1.15E−05 
                 9.8595365 
               
               
                 201235_s_at 
                 BTG2 
                 1.28386355 
                 7.44589095 
                 6.64539327 
                 1.07E−08 
                 1.39E−05 
                 9.65967492 
               
               
                 203927_at 
                 NFKBIE 
                 1.12895866 
                 9.72640239 
                 6.63162768 
                 1.13E−08 
                 1.44E−05 
                 9.61021946 
               
               
                 1553141_at 
                 C13ORF31 
                 1.19000046 
                 6.93831195 
                 6.55368898 
                 1.53E−08 
                 1.82E−05 
                 9.33038387 
               
               
                 220266_s_at 
                 KLF4 
                 1.1368523 
                 8.46464122 
                 6.55037647 
                 1.55E−08 
                 1.82E−05 
                 9.31849743 
               
               
                 217995_at 
                 SQRDL 
                 1.0793508 
                 12.336991 
                 6.54729812 
                 1.57E−08 
                 1.82E−05 
                 9.30745172 
               
               
                 207674_at 
                 FCAR 
                 1.24494467 
                 7.73429071 
                 6.53420308 
                 1.65E−08 
                 1.88E−05 
                 9.26047019 
               
               
                 46665_at 
                 SEMA4C 
                 1.10637799 
                 10.5657844 
                 6.4481698 
                 2.30E−08 
                 2.53E−05 
                 8.95205496 
               
               
                 210264_at 
                 GPR35 
                 1.11391738 
                 8.72115064 
                 6.44628003 
                 2.32E−08 
                 2.53E−05 
                 8.94528559 
               
               
                 211668_s_at 
                 PLAU 
                 1.11120293 
                 9.2353654 
                 6.42233001 
                 2.54E−08 
                 2.69E−05 
                 8.85951421 
               
               
                 205205_at 
                 RELB 
                 1.16492706 
                 7.34250559 
                 6.42094346 
                 2.56E−08 
                 2.69E−05 
                 8.85454977 
               
               
                 203798_s_at 
                 VSNL1 
                 1.16614475 
                 7.2833092 
                 6.41517707 
                 2.61E−08 
                 2.70E−05 
                 8.83390503 
               
               
                 219634_at 
                 CHST11 
                 1.11031386 
                 9.57653235 
                 6.40091795 
                 2.76E−08 
                 2.75E−05 
                 8.78286459 
               
               
                 201502_s_at 
                 NFKBIA 
                 1.14603586 
                 11.2391775 
                 6.40005102 
                 2.77E−08 
                 2.75E−05 
                 8.77976186 
               
               
                 229055_at 
                 GPR68 
                 1.14767352 
                 7.68909756 
                 6.36111525 
                 3.22E−08 
                 3.04E−05 
                 8.64046681 
               
               
                 212190_at 
                 SERPINE2 
                 1.12333317 
                 9.662056 
                 6.3519722 
                 3.34E−08 
                 3.04E−05 
                 8.60777296 
               
               
                 219386_s_at 
                 SLAMF8 
                 1.34835612 
                 8.40890612 
                 6.31827296 
                 3.80E−08 
                 3.41E−05 
                 8.48732535 
               
               
                 210513_s_at 
                 VEGF 
                 1.15191285 
                 8.36243556 
                 6.28246816 
                 4.36E−08 
                 3.85E−05 
                 8.35944956 
               
               
                 211527_x_at 
                 VEGF 
                 1.13731715 
                 7.87125822 
                 6.26106285 
                 4.74E−08 
                 4.11E−05 
                 8.28305106 
               
               
                 1555638_a_a 
                 SAMSN1 
                 1.16504788 
                 8.69549173 
                 6.24146956 
                 5.11E−08 
                 4.25E−05 
                 8.21315379 
               
               
                 204470_at 
                 CXCL1 
                 1.35501196 
                 7.67502936 
                 6.24129687 
                 5.11E−08 
                 4.25E−05 
                 8.2125379 
               
               
                 220935_s_at 
                 CDK5RAP2 
                 1.10875555 
                 9.47138345 
                 6.11902224 
                 8.18E−08 
                 6.48E−05 
                 7.7771196 
               
               
                 201236_s_at 
                 BTG2 
                 1.39106574 
                 9.51819834 
                 6.10195957 
                 8.73E−08 
                 6.72E−05 
                 7.71647403 
               
               
                 228648_at 
                 LRG1 
                 1.13667657 
                 10.1778893 
                 6.09346129 
                 9.02E−08 
                 6.85E−05 
                 7.68627977 
               
               
                 212143_s_at 
                 IGFBP3 
                 1.19756801 
                 7.50292055 
                 6.0375024 
                 1.12E−07 
                 8.26E−05 
                 7.48764791 
               
               
                 240076_at 
                 — 
                 1.11560154 
                 7.77294938 
                 6.02250815 
                 1.18E−07 
                 8.63E−05 
                 7.43448169 
               
               
                 215223_s_at 
                 SOD2 
                 1.08832613 
                 9.38708957 
                 6.00345187 
                 1.27E−07 
                 9.16E−05 
                 7.36694855 
               
               
                 208891_at 
                 DUSP6 
                 1.20973898 
                 11.4952332 
                 5.99682168 
                 1.31E−07 
                 9.18E−05 
                 7.34346158 
               
               
                 228967_at 
                 EIF1 
                 1.09256705 
                 7.51282579 
                 5.99430219 
                 1.32E−07 
                 9.18E−05 
                 7.33453779 
               
               
                 201489_at 
                 PPIF 
                 1.07056711 
                 11.9745223 
                 5.98944612 
                 1.34E−07 
                 9.18E−05 
                 7.31734011 
               
               
                 202388_at 
                 RGS2 
                 1.26773664 
                 9.57646356 
                 5.97863153 
                 1.40E−07 
                 9.45E−05 
                 7.27905017 
               
               
                 221903_s_at 
                 CYLD 
                 1.09642353 
                 9.26863731 
                 5.97193254 
                 1.44E−07 
                 9.58E−05 
                 7.25533872 
               
               
                 1560228_at 
                 SNAI3 
                 1.15060555 
                 7.09991102 
                 5.93825721 
                 1.63E−07 
                 0.0001076 
                 7.13622321 
               
               
                 227034_at 
                 ANKRD57 
                 1.22029842 
                 7.32299473 
                 5.88467981 
                 2.00E−07 
                 0.0001259 
                 6.94699581 
               
               
                 200878_at 
                 EPAS1 
                 1.12190973 
                 8.895976 
                 5.87823307 
                 2.05E−07 
                 0.00012757 
                 6.9242512 
               
               
                 201005_at 
                 CD9 
                 1.14821208 
                 9.10086802 
                 5.86983584 
                 2.12E−07 
                 0.00013023 
                 6.89463315 
               
               
                 206026_s_at 
                 TNFAIP6 
                 1.19240437 
                 5.36372703 
                 5.85839211 
                 2.21E−07 
                 0.00013373 
                 6.85428439 
               
               
                 214290_s_at 
                 HIST2H2AA / 
                 1.09794003 
                 11.8199009 
                 5.85526922 
                 2.24E−07 
                 0.00013373 
                 6.84327656 
               
               
                 222670_s_at 
                 MAFB 
                 1.20369944 
                 9.73888237 
                 5.854147 
                 2.25E−07 
                 0.00013373 
                 6.83932116 
               
               
                 205153_s_at 
                 CD40 
                 1.13334093 
                 8.72577521 
                 5.82226469 
                 2.54E−07 
                 0.00014934 
                 6.72701829 
               
               
                 225390_s_at 
                 KLF13 
                 1.08054083 
                 10.877664 
                 5.78479854 
                 2.93E−07 
                 0.00016854 
                 6.59522285 
               
               
                 227080_at 
                 ZNF697 
                 1.12343463 
                 8.92012752 
                 5.76864695 
                 3.11E−07 
                 0.000177 
                 6.5384663 
               
               
                 214056_at 
                 MCL1 
                 1.09148142 
                 8.9472801 
                 5.76468003 
                 3.16E−07 
                 0.000177 
                 6.52453225 
               
               
                 201739_at 
                 SGK 
                 1.28779242 
                 8.00577284 
                 5.75044243 
                 3.34E−07 
                 0.00018189 
                 6.47454023 
               
               
                 201170_s_at 
                 BHLHB2 
                 1.09531573 
                 9.50744497 
                 5.74853964 
                 3.36E−07 
                 0.00018189 
                 6.46786122 
               
               
                 205633_s_at 
                 ALAS1 
                 1.08179152 
                 11.5068057 
                 5.74324623 
                 3.43E−07 
                 0.00018376 
                 6.44928355 
               
               
                 203665_at 
                 HMOX1 
                 1.24623576 
                 9.15770135 
                 5.7289493 
                 3.62E−07 
                 0.00019209 
                 6.39912762 
               
               
                 203936_s_at 
                 MMP9 
                 1.145748 
                 8.56115455 
                 5.70212398 
                 4.01E−07 
                 0.0002066 
                 6.30510148 
               
               
                 213988_s_at 
                 SAT1 
                 1.12993548 
                 9.10818688 
                 5.68515244 
                 4.27E−07 
                 0.00021822 
                 6.24566986 
               
               
                 225097_at 
                 HIPK2 
                 1.16355832 
                 9.37790876 
                 5.66703291 
                 4.57E−07 
                 0.00023152 
                 6.18226665 
               
               
                 226218_at 
                 — 
                 1.2939063 
                 6.28386762 
                 5.66047476 
                 4.69E−07 
                 0.00023514 
                 6.15933112 
               
               
                 203939_at 
                 NT5E 
                 1.19431475 
                 7.2701384 
                 5.6470707 
                 4.93E−07 
                 0.00024509 
                 6.11247457 
               
               
                 221840_at 
                 PTPRE 
                 1.10358333 
                 8.99406461 
                 5.64033312 
                 5.06E−07 
                 0.00024914 
                 6.0889327 
               
               
                 234994_at 
                 KIAA1913 
                 1.26172422 
                 6.19165569 
                 5.61287248 
                 5.61E−07 
                 0.00026903 
                 5.99305687 
               
               
                 201169_s_at 
                 BHLHB2 
                 1.1138348 
                 7.81678741 
                 5.60701185 
                 5.73E−07 
                 0.00027264 
                 5.97261084 
               
               
                 223222_at 
                 SLC25A19 
                 1.06195494 
                 11.1387437 
                 5.60415209 
                 5.80E−07 
                 0.00027322 
                 5.96263602 
               
               
                 201250_s_at 
                 SLC2A1 
                 1.07198576 
                 9.45224146 
                 5.58245393 
                 6.29E−07 
                 0.00029287 
                 5.88699657 
               
               
                 205770_at 
                 GSR 
                 1.08507865 
                 10.4221632 
                 5.58115446 
                 6.32E−07 
                 0.00029287 
                 5.88246909 
               
               
                 211610_at 
                 KLF6 
                 1.21373848 
                 7.58295098 
                 5.56973288 
                 6.60E−07 
                 0.00030315 
                 5.84268743 
               
               
                 217996_at 
                 PHLDA1 
                 1.33234556 
                 7.22644861 
                 5.52201205 
                 7.89E−07 
                 0.00035373 
                 5.6767135 
               
               
                 204440_at 
                 CD83 
                 1.09559915 
                 9.65465598 
                 5.51721887 
                 8.04E−07 
                 0.00035722 
                 5.66006438 
               
               
                 203751_x_at 
                 JUND 
                 1.11709364 
                 8.15242666 
                 5.49344944 
                 8.78E−07 
                 0.00038425 
                 5.57756091 
               
               
                 220330_s_at 
                 SAMSN1 
                 1.16271877 
                 9.59945919 
                 5.48604123 
                 9.03E−07 
                 0.00038884 
                 5.55186756 
               
               
                 202644_s_at 
                 TNFAIP3 
                 1.10355352 
                 10.1094931 
                 5.47992259 
                 9.24E−07 
                 0.00039474 
                 5.53065412 
               
               
                 203797_at 
                 VSNL1 
                 1.10477681 
                 8.15296158 
                 5.47701685 
                 9.34E−07 
                 0.00039597 
                 5.52058224 
               
               
                 201069_at 
                 MMP2 
                 1.10375779 
                 8.40697176 
                 5.45565127 
                 1.01E−06 
                 0.00042561 
                 5.44657164 
               
               
                 204653_at 
                 TFAP2A 
                 1.17142932 
                 7.72005745 
                 5.44704422 
                 1.05E−06 
                 0.00043617 
                 5.41678026 
               
               
                 219385_at 
                 SLAMF8 
                 1.21995297 
                 7.92135191 
                 5.44342079 
                 1.06E−06 
                 0.00043648 
                 5.40424263 
               
               
                 208926_at 
                 NEU1 
                 1.08099136 
                 10.7507527 
                 5.44280336 
                 1.06E−06 
                 0.00043648 
                 5.40210647 
               
               
                 239412_at 
                 IRF5 
                 1.07460841 
                 10.9779751 
                 5.42713112 
                 1.13E−06 
                 0.00045596 
                 5.34790799 
               
               
                 223501_at 
                 — 
                 1.1103323 
                 9.76378918 
                 5.42513574 
                 1.13E−06 
                 0.00045596 
                 5.34101078 
               
               
                 201651_s_at 
                 PACSIN2 
                 1.05371079 
                 12.4689697 
                 5.41770064 
                 1.17E−06 
                 0.00046511 
                 5.31531719 
               
               
                 214211_at 
                 FTH1 
                 1.15283111 
                 10.7669406 
                 5.41590299 
                 1.17E−06 
                 0.00046511 
                 5.30910659 
               
               
                 202988_s_at 
                 RGS1 
                 1.26703574 
                 6.64018217 
                 5.37761912 
                 1.35E−06 
                 0.00052878 
                 5.17698759 
               
               
                 223303_at 
                 URP2 
                 1.07136267 
                 11.4584296 
                 5.36688864 
                 1.41E−06 
                 0.00054258 
                 5.14000695 
               
               
                 36711_at 
                 MAFF 
                 1.19353834 
                 6.77574709 
                 5.36039903 
                 1.44E−06 
                 0.00055196 
                 5.11765264 
               
               
                 203508_at 
                 TNFRSF1B 
                 1.11118203 
                 9.41800725 
                 5.35852346 
                 1.45E−06 
                 0.00055196 
                 5.1111935 
               
               
                 227645_at 
                 PIK3R5 
                 1.10436883 
                 8.17453287 
                 5.33951385 
                 1.56E−06 
                 0.0005883 
                 5.04576711 
               
               
                 218501_at 
                 ARHGEF3 
                 1.11215762 
                 8.30700755 
                 5.31477003 
                 1.71E−06 
                 0.00063184 
                 4.96071299 
               
               
                 209606_at 
                 PSCDBP 
                 1.18667973 
                 7.12974957 
                 5.30711238 
                 1.76E−06 
                 0.00064569 
                 4.93441572 
               
               
                 1555756_a_a 
                 CLEC7A 
                 1.21395231 
                 6.44819327 
                 5.2975806 
                 1.82E−06 
                 0.00066446 
                 4.90169919 
               
               
                 229354_at 
                 PDCD6 /// A           
                 1.08957565 
                 10.3878046 
                 5.29027036 
                 1.87E−06 
                 0.00067819 
                 4.87662042 
               
               
                 233955_x_at 
                 CXXC5 
                 1.07971504 
                 12.6052495 
                 5.27206493 
                 2.00E−06 
                 0.00071277 
                 4.81421221 
               
               
                 203887_s_at 
                 THBD 
                 1.14864911 
                 11.9807825 
                 5.27153474 
                 2.01E−06 
                 0.00071277 
                 4.81239575 
               
               
                 233540_s_at 
                 CDK5RAP2 
                 1.08483341 
                 10.2227011 
                 5.26920484 
                 2.03E−06 
                 0.00071431 
                 4.80441408 
               
               
                 209774_x_at 
                 CXCL2 
                 1.33797035 
                 6.42227624 
                 5.26653762 
                 2.05E−06 
                 0.00071677 
                 4.79527824 
               
               
                 210845_s_at 
                 PLAUR 
                 1.12269107 
                 10.7660847 
                 5.26173913 
                 2.08E−06 
                 0.0007209 
                 4.77884607 
               
               
                 225980_at 
                 C14ORF43 
                 1.0793459 
                 9.21104798 
                 5.23040107 
                 2.34E−06 
                 0.00079874 
                 4.67165036 
               
               
                 219039_at 
                 SEMA4C 
                 1.11139871 
                 9.52722178 
                 5.2215591 
                 2.41E−06 
                 0.0008154 
                 4.64144331 
               
               
                 228754_at 
                 SLC6A6 
                 1.11066199 
                 9.56424888 
                 5.21977863 
                 2.43E−06 
                 0.0008154 
                 4.63536267 
               
               
                 222062_at 
                 IL27RA 
                 1.14734393 
                 8.84896859 
                 5.21600492 
                 2.47E−06 
                 0.0008189 
                 4.62247702 
               
               
                 208892_s_at 
                 DUSP6 
                 1.19436158 
                 11.0841436 
                 5.21531302 
                 2.47E−06 
                 0.0008189 
                 4.62011481 
               
               
                 204684_at 
                 NPTX1 
                 1.28533088 
                 9.73612701 
                 5.20831506 
                 2.54E−06 
                 0.00083526 
                 4.59622895 
               
               
                 208373_s_at 
                 P2RY6 
                 1.06697743 
                 9.65819159 
                 5.20192905 
                 2.60E−06 
                 0.00084937 
                 4.57444113 
               
               
                 218856_at 
                 TNFRSF21 
                 1.11783326 
                 11.1389024 
                 5.20052327 
                 2.61E−06 
                 0.00084937 
                 4.56964607 
               
               
                 204436_at 
                 PLEKHQ1 
                 1.09698664 
                 9.3889143 
                 5.19357309 
                 2.68E−06 
                 0.0008652 
                 4.54594574 
               
               
                 212227_x_at 
                 EIF1 
                 1.05443994 
                 12.7811739 
                 5.19230534 
                 2.69E−06 
                 0.0008652 
                 4.54162382 
               
               
                 223125_s_at 
                 C1ORF21 
                 1.11079328 
                 10.4937493 
                 5.18218325 
                 2.79E−06 
                 0.00089281 
                 4.50712903 
               
               
                 217997_at 
                 PHLDA1 
                 1.26744571 
                 6.13655327 
                 5.17537259 
                 2.86E−06 
                 0.0009049 
                 4.48393197 
               
               
                 204912_at 
                 IL10RA 
                 1.12420434 
                 9.40611087 
                 5.17279988 
                 2.89E−06 
                 0.00090826 
                 4.47517201 
               
               
                 218417_s_at 
                 FLJ20489 
                 1.08815767 
                 9.3505492 
                 5.15361341 
                 3.10E−06 
                 0.0009514 
                 4.4098898 
               
               
                 203888_at 
                 THBD 
                 1.15159161 
                 10.9696824 
                 5.15288486 
                 3.11E−06 
                 0.0009514 
                 4.40741251 
               
               
                 205419_at 
                 EBI2 
                 1.18215692 
                 9.40684523 
                 5.1527513 
                 3.11E−06 
                 0.0009514 
                 4.4069584 
               
               
                 228708_at 
                 RAB27B 
                 1.18815027 
                 7.90684935 
                 5.15257387 
                 3.11E−06 
                 0.0009514 
                 4.40635511 
               
               
                 200644_at 
                 MARCKSL1 
                 1.10690452 
                 11.028723 
                 5.15248432 
                 3.11E−06 
                 0.0009514 
                 4.40605064 
               
               
                 202021_x_at 
                 EIF1 
                 1.05923104 
                 12.6600822 
                 5.1394264 
                 3.27E−06 
                 0.00099262 
                 4.36167177 
               
               
                 211653_x_at 
                 AKR1C2 
                 1.12714868 
                 8.13501584 
                 5.12100436 
                 3.50E−06 
                 0.00104753 
                 4.29912857 
               
               
                 209882_at 
                 RIT1 
                 1.10219332 
                 10.0435725 
                 5.12025544 
                 3.51E−06 
                 0.00104753 
                 4.29658764 
               
               
                 201467_s_at 
                 NQO1 
                 1.11423301 
                 9.57842418 
                 5.10680582 
                 3.68E−06 
                 0.00109451 
                 4.25097768 
               
               
                 225842_at 
                 PHLDA1 
                 1.16531676 
                 7.08579562 
                 5.09284521 
                 3.88E−06 
                 0.00114573 
                 4.20367946 
               
               
                 220091_at 
                 SLC2A6 
                 1.11656636 
                 9.02115478 
                 5.08631413 
                 3.97E−06 
                 0.00116392 
                 4.18156801 
               
               
                 200920_s_at 
                 BTG1 
                 1.06979743 
                 10.8993308 
                 5.08304104 
                 4.02E−06 
                 0.00116392 
                 4.17049051 
               
               
                 222703_s_at 
                 YRDC 
                 1.06438343 
                 10.3475422 
                 5.08288187 
                 4.02E−06 
                 0.00116392 
                 4.1699519 
               
               
                 201490_s_at 
                 PPIF 
                 1.05947022 
                 11.5950549 
                 5.07132874 
                 4.19E−06 
                 0.00120065 
                 4.13087206 
               
               
                 218223_s_at 
                 PLEKHO1 
                 1.12093336 
                 9.10575582 
                 5.06452081 
                 4.30E−06 
                 0.00122451 
                 4.10785829 
               
               
                 201851_at 
                 SH3GL1 
                 1.07901872 
                 9.65074195 
                 5.02668705 
                 4.94E−06 
                 0.00138427 
                 3.98016723 
               
               
                 228124_at 
                 ABHD12 
                 1.09977731 
                 7.66951417 
                 5.01836495 
                 5.09E−06 
                 0.00141465 
                 3.95212649 
               
               
                 218559_s_at 
                 MAFB 
                 1.22135659 
                 10.2200187 
                 5.01793255 
                 5.10E−06 
                 0.00141465 
                 3.95066998 
               
               
                 228696_at 
                 SLC45A3 
                 1.12825933 
                 7.72464342 
                 5.01306718 
                 5.19E−06 
                 0.00143268 
                 3.93428488 
               
               
                 223660_at 
                 ADORA3 
                 1.13136045 
                 7.77795316 
                 4.98586352 
                 5.73E−06 
                 0.00155048 
                 3.84277934 
               
               
                 220066_at 
                 CARD15 
                 1.12730802 
                 7.8810279 
                 4.98180156 
                 5.81E−06 
                 0.0015658 
                 3.82913191 
               
               
                 238542_at 
                 ULBP2 
                 1.10589961 
                 7.94992924 
                 4.9769201 
                 5.92E−06 
                 0.00158601 
                 3.81273664 
               
               
                 224480_s_at 
                 LPAAT-THET           
                 1.20881651 
                 8.02630766 
                 4.96873318 
                 6.10E−06 
                 0.00162593 
                 3.78525289 
               
               
                 207469_s_at 
                 PIR 
                 1.10472357 
                 9.02435046 
                 4.96686989 
                 6.14E−06 
                 0.00162902 
                 3.77900012 
               
               
                 202241_at 
                 TRIB1 
                 1.67898747 
                 9.30574701 
                 4.94914352 
                 6.55E−06 
                 0.00172797 
                 3.71955903 
               
               
                 204975_at 
                 EMP2 
                 1.07979325 
                 8.71044082 
                 4.94102597 
                 6.74E−06 
                 0.00176349 
                 3.69236569 
               
               
                 226354_at 
                 LACTB 
                 1.06792187 
                 9.9828876 
                 4.93326158 
                 6.93E−06 
                 0.00179962 
                 3.66637136 
               
               
                 226022_at 
                 SASH1 
                 1.07960243 
                 11.2682799 
                 4.93280332 
                 6.95E−06 
                 0.00179962 
                 3.66483764 
               
               
                 228869_at 
                 SLIC1 
                 1.07164715 
                 9.82112889 
                 4.92528486 
                 7.14E−06 
                 0.00184057 
                 3.63968244 
               
               
                 203752_s_at 
                 JUND 
                 1.08201127 
                 11.8110521 
                 4.92340249 
                 7.19E−06 
                 0.00184446 
                 3.63338672 
               
               
                 212130_x_at 
                 EIF1 
                 1.05588847 
                 12.6471904 
                 4.91712987 
                 7.35E−06 
                 0.00187608 
                 3.6124142 
               
               
                 219593_at 
                 SLC15A3 
                 1.08615216 
                 8.63335571 
                 4.91416769 
                 7.43E−06 
                 0.00187608 
                 3.60251376 
               
               
                 236570_at 
                 ZNF366 
                 1.23552697 
                 5.63015267 
                 4.91397465 
                 7.43E−06 
                 0.00187608 
                 3.60186863 
               
               
                 213236_at 
                 SASH1 
                 1.09881243 
                 10.3511094 
                 4.91356632 
                 7.45E−06 
                 0.00187608 
                 3.60050408 
               
               
                 225609_at 
                 GSR 
                 1.08973861 
                 9.95822522 
                 4.90544456 
                 7.67E−06 
                 0.00192315 
                 3.57337186 
               
               
                 205891_at 
                 ADORA2B 
                 1.11169386 
                 9.89367673 
                 4.87112294 
                 8.68E−06 
                 0.00216282 
                 3.45890752 
               
               
                 228438_at 
                 TRPA1 
                 1.12226677 
                 8.86862388 
                 4.87039478 
                 8.70E−06 
                 0.00216282 
                 3.45648245 
               
               
                 226372_at 
                 CHST11 
                 1.08446345 
                 11.0281604 
                 4.8686604 
                 8.76E−06 
                 0.00216654 
                 3.45070693 
               
               
                 204961_s_at 
                 NCF1 /// LO           
                 1.09199637 
                 10.3669364 
                 4.86594187 
                 8.84E−06 
                 0.00217803 
                 3.44165575 
               
               
                 212124_at 
                 RAI17 
                 1.09160138 
                 9.61628437 
                 4.84935418 
                 9.39E−06 
                 0.00230182 
                 3.38647153 
               
               
                 204341_at 
                 TRIM16 /// T           
                 1.10230923 
                 8.04807245 
                 4.83779913 
                 9.79E−06 
                 0.0023573 
                 3.34807425 
               
               
                 233857_s_at 
                 ASB2 
                 1.10322519 
                 6.77376513 
                 4.82807168 
                 1.01E−05 
                 0.00243053 
                 3.31577846 
               
               
                 205479_s_at 
                 PLAU 
                 1.08239048 
                 9.99849286 
                 4.82413541 
                 1.03E−05 
                 0.00244373 
                 3.30271717 
               
               
                 202252_at 
                 RAB13 
                 1.04918345 
                 12.5262785 
                 4.81495419 
                 1.06E−05 
                 0.00251476 
                 3.27226887 
               
               
                 204363_at 
                 F3 
                 1.13756401 
                 8.52817386 
                 4.80950401 
                 1.08E−05 
                 0.00254245 
                 3.25420514 
               
               
                 226389_s_at 
                 RAPGEF1 
                 1.09449369 
                 10.0900401 
                 4.80799583 
                 1.09E−05 
                 0.00254533 
                 3.24920801 
               
               
                 238893_at 
                 LOC338758 
                 1.19879171 
                 8.45854652 
                 4.79847311 
                 1.13E−05 
                 0.00260733 
                 3.21767044 
               
               
                 1559399_s_at 
                 ZCCHC10 
                 1.08397924 
                 9.324417 
                 4.79836233 
                 1.13E−05 
                 0.00260733 
                 3.21730369 
               
               
                 213281_at 
                 JUN 
                 1.32929059 
                 8.21180845 
                 4.79539679 
                 1.14E−05 
                 0.00260733 
                 3.20748765 
               
               
                 35150_at 
                 CD40 
                 1.0785382 
                 10.2548276 
                 4.7810706 
                 1.20E−05 
                 0.00272195 
                 3.16010228 
               
               
                 237252_at 
                 THBD 
                 1.17836626 
                 8.93981242 
                 4.7780675 
                 1.21E−05 
                 0.00274002 
                 3.15017657 
               
               
                 204908_s_at 
                 BCL3 
                 1.15086138 
                 7.37503762 
                 4.76630513 
                 1.26E−05 
                 0.00282288 
                 3.11132484 
               
               
                 200884_at 
                 CKB 
                 1.07535296 
                 9.92747723 
                 4.76403187 
                 1.28E−05 
                 0.00282288 
                 3.10382067 
               
               
                 222996_s_at 
                 CXXC5 
                 1.07526087 
                 11.470336 
                 4.76122287 
                 1.29E−05 
                 0.0028399 
                 3.09455008 
               
               
                 209949_at 
                 NCF2 
                 1.0957522 
                 12.1194106 
                 4.75475484 
                 1.32E−05 
                 0.00289468 
                 3.07321208 
               
               
                 214175_x_at 
                 PDLIM4 
                 1.10938746 
                 10.0654194 
                 4.75115423 
                 1.34E−05 
                 0.00292045 
                 3.06133891 
               
               
                 211924_s_at 
                 PLAUR 
                 1.11165511 
                 9.95057637 
                 4.74398245 
                 1.37E−05 
                 0.00298199 
                 3.0377008 
               
               
                 208786_s_at 
                 MAP1LC3B 
                 1.06211193 
                 10.0695592 
                 4.71562836 
                 1.52E−05 
                 0.00321787 
                 2.94439234 
               
               
                 211005_at 
                 LAT 
                 1.08938993 
                 7.96306748 
                 4.71210161 
                 1.54E−05 
                 0.00324053 
                 2.93280287 
               
               
                 205681_at 
                 BCL2A1 
                 1.21178632 
                 7.93446379 
                 4.70888129 
                 1.55E−05 
                 0.00326531 
                 2.92222355 
               
               
                 239529_at 
                 C5ORF20 
                 1.07787194 
                 9.92848977 
                 4.70651414 
                 1.57E−05 
                 0.00328034 
                 2.91444905 
               
               
                 211564_s_at 
                 PDLIM4 
                 1.14599993 
                 9.5625589 
                 4.69674734 
                 1.62E−05 
                 0.00338345 
                 2.88238905 
               
               
                 216834_at 
                 RGS1 
                 1.23977301 
                 8.08711615 
                 4.69312858 
                 1.64E−05 
                 0.00341426 
                 2.87051745 
               
               
                 205468_s_at 
                 IRF5 
                 1.07554402 
                 9.22742578 
                 4.6798859 
                 1.72E−05 
                 0.00356532 
                 2.82710733 
               
               
                 201465_s_at 
                 JUN 
                 1.4322588 
                 8.69995542 
                 4.64844489 
                 1.92E−05 
                 0.00391212 
                 2.72425354 
               
               
                 204059_s_at 
                 ME1 
                 1.12987509 
                 10.6613264 
                 4.64336736 
                 1.96E−05 
                 0.0039684 
                 2.70767146 
               
               
                 219926_at 
                 POPDC3 
                 1.14627403 
                 7.07974513 
                 4.62989868 
                 2.06E−05 
                 0.00414687 
                 2.66372393 
               
               
                 203217_s_at 
                 ST3GAL5 
                 1.09010335 
                 8.64299026 
                 4.61328701 
                 2.18E−05 
                 0.00431813 
                 2.60959806 
               
               
                 203140_at 
                 BCL6 
                 1.09370126 
                 9.09728992 
                 4.60731699 
                 2.23E−05 
                 0.00435798 
                 2.59016685 
               
               
                 223394_at 
                 SERTAD1 
                 1.09520636 
                 8.8545176 
                 4.60661454 
                 2.23E−05 
                 0.00435798 
                 2.58788125 
               
               
                 1555832_s_at 
                 KLF6 
                 1.3281372 
                 9.3646245 
                 4.60196013 
                 2.27E−05 
                 0.00439877 
                 2.57274081 
               
               
                 202181_at 
                 KIAA0247 
                 1.06968044 
                 10.7870044 
                 4.59786925 
                 2.30E−05 
                 0.00444699 
                 2.55943906 
               
               
                 215346_at 
                 CD40 
                 1.11448836 
                 7.24866952 
                 4.58843542 
                 2.38E−05 
                 0.00458129 
                 2.52878443 
               
               
                 1554036_at 
                 ZBTB24 
                 1.18706647 
                 7.29410595 
                 4.57607014 
                 2.49E−05 
                 0.00473788 
                 2.48864674 
               
               
                 227345_at 
                 TNFRSF10D 
                 1.11676877 
                 7.04849796 
                 4.57591796 
                 2.49E−05 
                 0.00473788 
                 2.48815304 
               
               
                 238638_at 
                 SLC37A2 
                 1.13101655 
                 8.61062051 
                 4.57336536 
                 2.51E−05 
                 0.00474087 
                 2.47987348 
               
               
                 221841_s_at 
                 KLF4 
                 1.10113355 
                 10.8767227 
                 4.57011234 
                 2.54E−05 
                 0.00474759 
                 2.469325 
               
               
                 219256_s_at 
                 SH3TC1 
                 1.11536627 
                 7.53451496 
                 4.56946119 
                 2.54E−05 
                 0.00474759 
                 2.46721395 
               
               
                 1555950_a_a 
                 CD55 
                 1.09152724 
                 10.0342225 
                 4.56489196 
                 2.59E−05 
                 0.00479572 
                 2.45240406 
               
               
                 204702_s_at 
                 NFE2L3 
                 1.12411725 
                 7.17327917 
                 4.56338707 
                 2.60E−05 
                 0.00479572 
                 2.44752785 
               
               
                 227811_at 
                 FGD3 
                 1.06629472 
                 10.1971288 
                 4.56331445 
                 2.60E−05 
                 0.00479572 
                 2.44729254 
               
               
                 205505_at 
                 GCNT1 
                 1.07750113 
                 9.23709484 
                 4.55594632 
                 2.67E−05 
                 0.00487889 
                 2.42342858 
               
               
                 224397_s_at 
                 TMTC1 /// L           
                 1.0620857 
                 9.26567514 
                 4.550558 
                 2.72E−05 
                 0.0049228 
                 2.40598784 
               
               
                 201642_at 
                 IFNGR2 
                 1.05959086 
                 11.6162722 
                 4.54471501 
                 2.78E−05 
                 0.00499333 
                 2.38708599 
               
               
                 206508_at 
                 TNFSF7 
                 1.05574374 
                 11.4883906 
                 4.54463083 
                 2.78E−05 
                 0.00499333 
                 2.38681375 
               
               
                 208091_s_at 
                 ECOP 
                 1.04916375 
                 11.1694214 
                 4.54122019 
                 2.81E−05 
                 0.00502048 
                 2.37578563 
               
               
                 200797_s_at 
                 MCL1 
                 1.07430577 
                 12.8237735 
                 4.53733476 
                 2.85E−05 
                 0.00507286 
                 2.36322689 
               
               
                 224516_s_at 
                 CXXC5 
                 1.06346079 
                 12.1814931 
                 4.5350953 
                 2.87E−05 
                 0.0050963 
                 2.35599058 
               
               
                 202838_at 
                 FUCA1 
                 1.08015905 
                 8.59058103 
                 4.52575753 
                 2.97E−05 
                 0.00521504 
                 2.32586748 
               
               
                 218902_at 
                 NOTCH1 
                 1.07544712 
                 10.0281701 
                 4.51751651 
                 3.05E−05 
                 0.00535088 
                 2.29924525 
               
               
                 1556314_a_a 
                 — 
                 1.19283635 
                 8.47221892 
                 4.51444845 
                 3.09E−05 
                 0.00539144 
                 2.2893517 
               
               
                 212552_at 
                 HPCAL1 
                 1.05856719 
                 11.9497308 
                 4.51088571 
                 3.13E−05 
                 0.00541251 
                 2.27786684 
               
               
                 220307_at 
                 CD244 
                 1.06735723 
                 10.3372156 
                 4.50054668 
                 3.24E−05 
                 0.00557134 
                 2.24456149 
               
               
                 1555827_at 
                 CCNL1 
                 1.31890926 
                 6.17504609 
                 4.49891525 
                 3.26E−05 
                 0.00558567 
                 2.23930934 
               
               
                 205349_at 
                 GNA15 
                 1.06857174 
                 8.74643664 
                 4.49799127 
                 3.27E−05 
                 0.00558624 
                 2.23633511 
               
               
                 210785_s_at 
                 C1ORF38 
                 1.10692612 
                 9.80722622 
                 4.4919076 
                 3.34E−05 
                 0.00568834 
                 2.21675923 
               
               
                 209568_s_at 
                 RGL1 
                 1.09184408 
                 7.96502675 
                 4.49062407 
                 3.35E−05 
                 0.00568834 
                 2.21263071 
               
               
                 212298_at 
                 NRP1 
                 1.20491357 
                 7.7598722 
                 4.49014314 
                 3.36E−05 
                 0.00568834 
                 2.21108391 
               
               
                 223145_s_at 
                 C6ORF166 
                 1.05608761 
                 11.4884714 
                 4.48713202 
                 3.40E−05 
                 0.00573078 
                 2.20140111 
               
               
                 204257_at 
                 FADS3 
                 1.09493945 
                 8.41951964 
                 4.48151372 
                 3.46E−05 
                 0.0058264 
                 2.18334247 
               
               
                 202686_s_at 
                 AXL 
                 1.09254285 
                 8.17667586 
                 4.47347755 
                 3.56E−05 
                 0.0059656 
                 2.15753052 
               
               
                 216080_s_at 
                 FADS3 
                 1.09835074 
                 8.00176994 
                 4.46781128 
                 3.63E−05 
                 0.00601925 
                 2.13934359 
               
               
                 223392_s_at 
                 TSHZ3 
                 1.06527254 
                 7.90879098 
                 4.46593878 
                 3.66E−05 
                 0.00604039 
                 2.13333582 
               
               
                 55093_at 
                 CSGLCA-T 
                 1.06274155 
                 9.78511615 
                 4.4615716 
                 3.71E−05 
                 0.00611247 
                 2.11964927 
               
               
                 234351_x_at 
                 TRPS1 
                 1.08022797 
                 8.01237377 
                 4.45917263 
                 3.74E−05 
                 0.00612832 
                 2.11163694 
               
               
                 212882_at 
                 KLHL18 
                 1.05377934 
                 9.17946015 
                 4.45890277 
                 3.75E−05 
                 0.00612832 
                 2.11077186 
               
               
                 230698_at 
                 — 
                 1.13801592 
                 5.25817407 
                 4.45834849 
                 3.75E−05 
                 0.00612832 
                 2.10899501 
               
               
                 1553142_at 
                 C13ORF31 
                 1.22937031 
                 5.40269403 
                 4.45539446 
                 3.79E−05 
                 0.0061733 
                 2.09952717 
               
               
                 215195_at 
                 PRKCA 
                 1.07061108 
                 8.15580417 
                 4.4501435 
                 3.86E−05 
                 0.0062686 
                 2.08270483 
               
               
                 223305_at 
                 MGC13379 
                 1.04781874 
                 10.291887 
                 4.44708307 
                 3.91E−05 
                 0.00631099 
                 2.07290452 
               
               
                 212681_at 
                 EPB41L3 
                 1.16483629 
                 6.50195379 
                 4.44605331 
                 3.92E−05 
                 0.00631099 
                 2.06960767 
               
               
                 212225_at 
                 EIF1 
                 1.29978025 
                 8.27092573 
                 4.42703387 
                 4.19E−05 
                 0.00665515 
                 2.00878036 
               
               
                 235299_at 
                 — 
                 1.16674528 
                 5.45895742 
                 4.42210056 
                 4.26E−05 
                 0.00675057 
                 1.993023 
               
               
                 221658_s_at 
                 IL21R 
                 1.1069911 
                 6.7874754 
                 4.41756867 
                 4.33E−05 
                 0.00681813 
                 1.97855514 
               
               
                 223276_at 
                 MST150 
                 1.04156368 
                 11.4183626 
                 4.40792637 
                 4.47E−05 
                 0.00696979 
                 1.9477961 
               
               
                 218280_x_at 
                 HIST2H2AA /           
                 1.08743247 
                 10.2812164 
                 4.40125238 
                 4.58E−05 
                 0.00711271 
                 1.92652478 
               
               
                 218647_s_at 
                 YRDC 
                 1.06300514 
                 9.78941527 
                 4.38080776 
                 4.92E−05 
                 0.00752763 
                 1.86146015 
               
               
                 218589_at 
                 P2RY5 
                 1.1167465 
                 8.63436917 
                 4.37437741 
                 5.03E−05 
                 0.00764929 
                 1.84102585 
               
               
                 207535_s_at 
                 NFKB2 
                 1.10079929 
                 6.90974535 
                 4.37295025 
                 5.05E−05 
                 0.00764929 
                 1.8364926 
               
               
                 230925_at 
                 APBB1IP 
                 1.06629311 
                 12.0575087 
                 4.35935406 
                 5.29E−05 
                 0.00795107 
                 1.79334155 
               
               
                 48106_at 
                 FLJ20489 
                 1.0637033 
                 9.15515486 
                 4.35698216 
                 5.34E−05 
                 0.00799448 
                 1.78582038 
               
               
                 210872_x_at 
                 GAS7 
                 1.08154753 
                 7.70819207 
                 4.35585799 
                 5.36E−05 
                 0.00800363 
                 1.78225642 
               
               
                 204359_at 
                 FLRT2 
                 1.14647669 
                 7.31270266 
                 4.35162998 
                 5.44E−05 
                 0.00806509 
                 1.76885628 
               
               
                 235457_at 
                 MAML2 
                 1.11934624 
                 7.88052648 
                 4.35157862 
                 5.44E−05 
                 0.00806509 
                 1.76869354 
               
               
                 209239_at 
                 NFKB1 
                 1.06667957 
                 9.95829149 
                 4.34970949 
                 5.47E−05 
                 0.00808685 
                 1.76277161 
               
               
                 57163_at 
                 ELOVL1 
                 1.03977111 
                 11.2971996 
                 4.34572593 
                 5.55E−05 
                 0.00815484 
                 1.75015477 
               
               
                 218145_at 
                 TRIB3 
                 1.05938261 
                 11.0204954 
                 4.33624331 
                 5.73E−05 
                 0.00835029 
                 1.7201439 
               
               
                 211776_s_at 
                 EPB41L3 
                 1.13532577 
                 6.97220625 
                 4.3357415 
                 5.74E−05 
                 0.00835029 
                 1.71855664 
               
               
                 203455_s_at 
                 SAT1 
                 1.1106924 
                 10.2329144 
                 4.32750295 
                 5.91E−05 
                 0.00843913 
                 1.69251066 
               
               
                 207571_x_at 
                 C1ORF38 
                 1.09650304 
                 9.82311518 
                 4.32655202 
                 5.93E−05 
                 0.00843913 
                 1.68950588 
               
               
                 211661_x_at 
                 PTAFR 
                 1.09097156 
                 8.56515505 
                 4.32283339 
                 6.00E−05 
                 0.00852559 
                 1.67775875 
               
               
                 201590_x_at 
                 ANXA2 
                 1.0821024 
                 12.5151345 
                 4.29910185 
                 6.51E−05 
                 0.00910791 
                 1.60290884 
               
               
                 202071_at 
                 SDC4 
                 1.10346382 
                 9.40347252 
                 4.29057952 
                 6.71E−05 
                 0.00933036 
                 1.57607916 
               
               
                 208983_s_at 
                 PECAM1 
                 1.05734731 
                 11.7319933 
                 4.28529786 
                 6.83E−05 
                 0.00945271 
                 1.55946497 
               
               
                 205098_at 
                 CCR1 
                 1.06303521 
                 11.4600607 
                 4.28157126 
                 6.92E−05 
                 0.00952594 
                 1.54774856 
               
               
                 200839_s_at 
                 CTSB 
                 1.0495602 
                 12.4472914 
                 4.27935833 
                 6.97E−05 
                 0.00952643 
                 1.54079356 
               
               
                 205503_at 
                 PTPN14 
                 1.11449101 
                 5.88707054 
                 4.27156243 
                 7.16E−05 
                 0.00973541 
                 1.51630622 
               
               
                 204998_s_at 
                 ATF5 
                 1.09981149 
                 9.30480593 
                 4.26739042 
                 7.26E−05 
                 0.00985086 
                 1.50321093 
               
               
                 208961_s_at 
                 KLF6 
                 1.23937112 
                 8.76862028 
                 4.26084325 
                 7.43E−05 
                 0.00997486 
                 1.48267336 
               
               
                 211962_s_at 
                 ZFP36L1 
                 1.14336043 
                 7.45775693 
                 4.25626247 
                 7.54E−05 
                 0.01008195 
                 1.46831355 
               
               
                 223502_s_at 
                 TNFSF13B 
                 1.09556837 
                 9.8619397 
                 4.25432078 
                 7.59E−05 
                 0.01008195 
                 1.46222911 
               
               
                 212062_at 
                 ATP9A 
                 1.12049998 
                 7.42652014 
                 4.24093141 
                 7.95E−05 
                 0.01044325 
                 1.42031066 
               
               
                 222165_x_at 
                 C9ORF16 
                 1.06651407 
                 9.91796752 
                 4.24002979 
                 7.97E−05 
                 0.01044325 
                 1.41749035 
               
               
                 201926_s_at 
                 CD55 
                 1.09241207 
                 9.80032696 
                 4.23706219 
                 8.05E−05 
                 0.01046218 
                 1.40820968 
               
               
                 214446_at 
                 ELL2 
                 1.08240974 
                 7.5600877 
                 4.23640074 
                 8.07E−05 
                 0.01046218 
                 1.40614158 
               
               
                 205718_at 
                 ITGB7 
                 1.06295759 
                 9.27615896 
                 4.23403904 
                 8.14E−05 
                 0.01049314 
                 1.39875869 
               
               
                 216504_s_at 
                 SLC39A8 
                 1.10938409 
                 7.59501292 
                 4.23284649 
                 8.17E−05 
                 0.01049314 
                 1.3950315 
               
               
                 221799_at 
                 CSGLCA-T 
                 1.07612526 
                 9.24334654 
                 4.23263401 
                 8.18E−05 
                 0.01049314 
                 1.39436746 
               
               
                 1554406_a_a 
                 CLEC7A 
                 1.10481365 
                 7.94057206 
                 4.23125877 
                 8.21E−05 
                 0.01051774 
                 1.39007005 
               
               
                 41644_at 
                 SASH1 
                 1.07635742 
                 10.9010644 
                 4.22769131 
                 8.31E−05 
                 0.01058985 
                 1.3789256 
               
               
                 238669_at 
                 PTGS1 
                 1.10119423 
                 8.07043819 
                 4.21299805 
                 8.74E−05 
                 0.01101178 
                 1.33307571 
               
               
                 211571_s_at 
                 CSPG2 
                 1.11087565 
                 8.5143978 
                 4.21117973 
                 8.80E−05 
                 0.01105461 
                 1.32740739 
               
               
                 203702_s_at 
                 TTLL4 
                 1.05712621 
                 8.43342998 
                 4.2038303 
                 9.02E−05 
                 0.01130824 
                 1.30450953 
               
               
                 209906_at 
                 C3AR1 
                 1.12163622 
                 7.99304364 
                 4.19174628 
                 9.40E−05 
                 0.01159647 
                 1.26690537 
               
               
                 221752_at 
                 SSH1 
                 1.06296062 
                 8.5565014 
                 4.18795524 
                 9.52E−05 
                 0.011693 
                 1.25511957 
               
               
                 204655_at 
                 CCL5 
                 1.08067913 
                 11.8965338 
                 4.18339572 
                 9.67E−05 
                 0.01179566 
                 1.24095201 
               
               
                 1555788_a_a 
                 TRIB3 
                 1.07151286 
                 9.51438422 
                 4.18231045 
                 9.70E−05 
                 0.01181277 
                 1.23758099 
               
               
                 209160_at 
                 AKR1C3 
                 1.14905554 
                 5.73155063 
                 4.17829766 
                 9.83E−05 
                 0.0118711 
                 1.22512056 
               
               
                 224783_at 
                 FAM100B 
                 1.05774261 
                 9.77579353 
                 4.17654931 
                 9.89E−05 
                 0.0118964 
                 1.21969356 
               
               
                 203549_s_at 
                 LPL 
                 1.05114008 
                 12.062737 
                 4.17631113 
                 9.90E−05 
                 0.0118964 
                 1.21895431 
               
               
                 230343_at 
                 — 
                 1.0958987 
                 7.39528117 
                 4.17213744 
                 0.00010041 
                 0.01203929 
                 1.20600404 
               
               
                 201925_s_at 
                 CD55 
                 1.12915465 
                 9.47556264 
                 4.16888144 
                 0.00010152 
                 0.01212964 
                 1.19590588 
               
               
                 214581_x_at 
                 TNFRSF21 
                 1.11185517 
                 9.56118012 
                 4.16612537 
                 0.00010247 
                 0.01220649 
                 1.18736144 
               
               
                 215813_s_at 
                 PTGS1 
                 1.06554211 
                 10.1951822 
                 4.16354389 
                 0.00010337 
                 0.0122868 
                 1.17936091 
               
               
                 39582_at 
                 CYLD 
                 1.07942531 
                 7.63563499 
                 4.16212948 
                 0.00010387 
                 0.01231894 
                 1.17497847 
               
               
                 219890_at 
                 CLEC5A 
                 1.14451027 
                 8.86385658 
                 4.15970971 
                 0.00010472 
                 0.01239328 
                 1.16748282 
               
               
                 224218_s_at 
                 TRPS1 
                 1.10873593 
                 7.212934 
                 4.15691737 
                 0.00010572 
                 0.01243643 
                 1.15883589 
               
               
                 207275_s_at 
                 ACSL1 
                 1.06382835 
                 10.2365501 
                 4.15687886 
                 0.00010573 
                 0.01243643 
                 1.15871663 
               
               
                 1560485_at 
                 HIVEP1 
                 1.09963892 
                 6.29901302 
                 4.14268989 
                 0.00011092 
                 0.01282144 
                 1.11482542 
               
               
                 224967_at 
                 UGCG 
                 1.07551513 
                 9.81750879 
                 4.13803967 
                 0.00011267 
                 0.01294212 
                 1.1004579 
               
               
                 235479_at 
                 CPEB2 
                 1.05886438 
                 8.76040386 
                 4.13334561 
                 0.00011447 
                 0.01305473 
                 1.08596354 
               
               
                 205323_s_at 
                 MTF1 
                 1.05603723 
                 9.75949747 
                 4.13204585 
                 0.00011497 
                 0.01305473 
                 1.08195167 
               
               
                 202643_s_at 
                 TNFAIP3 
                 1.09192276 
                 8.84841512 
                 4.13157653 
                 0.00011516 
                 0.01305473 
                 1.0805032 
               
               
                 202948_at 
                 IL1R1 
                 1.11651018 
                 6.61849267 
                 4.13003859 
                 0.00011575 
                 0.01305473 
                 1.07575731 
               
               
                 205469_s_at 
                 IRF5 
                 1.05102073 
                 11.1050752 
                 4.12871511 
                 0.00011627 
                 0.01305473 
                 1.07167395 
               
               
                 211676_s_at 
                 IFNGR1 
                 1.05547086 
                 11.597122 
                 4.11880246 
                 0.00012022 
                 0.01335977 
                 1.04111224 
               
               
                 226039_at 
                 MGAT4A 
                 1.06778678 
                 10.4027019 
                 4.10156128 
                 0.0001274 
                 0.01404306 
                 0.98804884 
               
               
                 213763_at 
                 HIPK2 
                 1.10105649 
                 7.77301596 
                 4.09563418 
                 0.00012996 
                 0.01425665 
                 0.96983433 
               
               
                 222877_at 
                 NRP2 
                 1.15705726 
                 5.02483818 
                 4.09527073 
                 0.00013012 
                 0.01425665 
                 0.96871786 
               
               
                 228186_s_at 
                 RSPO3 
                 1.14318575 
                 5.7292516 
                 4.09151825 
                 0.00013176 
                 0.01437971 
                 0.95719398 
               
               
                 228640_at 
                 — 
                 1.18540594 
                 4.77536947 
                 4.08751237 
                 0.00013355 
                 0.01454523 
                 0.94489812 
               
               
                 1558404_at 
                 LOC644242 /           
                 1.23417115 
                 5.05041215 
                 4.08679741 
                 0.00013387 
                 0.01455116 
                 0.94270427 
               
               
                 1554966_a_a 
                 DOC1 
                 1.09595173 
                 8.58722147 
                 4.0855338 
                 0.00013444 
                 0.01456531 
                 0.93882738 
               
               
                 209803_s_at 
                 PHLDA2 
                 1.09168215 
                 8.97143045 
                 4.08488393 
                 0.00013473 
                 0.01456531 
                 0.93683375 
               
               
                 1555759_a_a 
                 CCL5 
                 1.08590053 
                 12.3665501 
                 4.08473429 
                 0.0001348 
                 0.01456531 
                 0.93637472 
               
               
                 205322_s_at 
                 MTF1 
                 1.06116697 
                 9.07418068 
                 4.07720028 
                 0.00013824 
                 0.01490832 
                 0.91327536 
               
               
                 204197_s_at 
                 RUNX3 
                 1.07101524 
                 9.2606011 
                 4.075793 
                 0.0001389 
                 0.01494692 
                 0.90896318 
               
               
                 224785_at 
                 FAM100B 
                 1.06028293 
                 9.68830224 
                 4.07291553 
                 0.00014024 
                 0.01494692 
                 0.90014852 
               
               
                 204011_at 
                 SPRY2 
                 1.07921096 
                 9.36460861 
                 4.06326541 
                 0.00014485 
                 0.01535236 
                 0.87061139 
               
               
                 218673_s_at 
                 ATG7 
                 1.0429976 
                 10.1275004 
                 4.063176 
                 0.00014489 
                 0.01535236 
                 0.87033789 
               
               
                 244434_at 
                 — 
                 1.20479383 
                 5.19908075 
                 4.05858303 
                 0.00014713 
                 0.01555469 
                 0.85629319 
               
               
                 203313_s_at 
                 TGIF 
                 1.07792023 
                 9.34545441 
                 4.05661779 
                 0.0001481 
                 0.01555469 
                 0.85028636 
               
               
                 214057_at 
                 MCL1 
                 1.08299074 
                 8.45324848 
                 4.05637551 
                 0.00014822 
                 0.01555469 
                 0.84954593 
               
               
                 201473_at 
                 JUNB 
                 1.18429728 
                 8.79340992 
                 4.05365798 
                 0.00014957 
                 0.01564376 
                 0.84124255 
               
               
                 203234_at 
                 UPP1 
                 1.11194547 
                 9.00007417 
                 4.05220054 
                 0.0001503 
                 0.01565768 
                 0.83679059 
               
               
                 223126_s_at 
                 C1ORF21 
                 1.0962014 
                 8.74641324 
                 4.05101842 
                 0.0001509 
                 0.01565768 
                 0.83318028 
               
               
                 203604_at 
                 ZNF516 
                 1.06761148 
                 9.49503774 
                 4.05097313 
                 0.00015092 
                 0.01565768 
                 0.83304199 
               
               
                 219398_at 
                 CIDEC 
                 1.06603998 
                 7.6766591 
                 4.05011563 
                 0.00015135 
                 0.01567285 
                 0.83042347 
               
               
                 241418_at 
                 — 
                 1.11426423 
                 6.19780118 
                 4.04745294 
                 0.00015271 
                 0.01578293 
                 0.82229445 
               
               
                 239845_at 
                 — 
                 1.14637752 
                 5.55035202 
                 4.04641564 
                 0.00015324 
                 0.01580779 
                 0.81912842 
               
               
                 214010_s_at 
                 ATP9B 
                 1.05604217 
                 8.49566348 
                 4.04162949 
                 0.0001557 
                 0.01601409 
                 0.80452591 
               
               
                 201063_at 
                 RCN1 
                 1.05280589 
                 9.82235338 
                 4.02360178 
                 0.00016534 
                 0.01680334 
                 0.74960812 
               
               
                 226064_s_at 
                 DGAT2 
                 1.05258611 
                 9.74527668 
                 4.00179079 
                 0.00017778 
                 0.01786795 
                 0.68334514 
               
               
                 212419_at 
                 C10ORF56 
                 1.07773109 
                 8.71242101 
                 3.99856112 
                 0.0001797 
                 0.01799441 
                 0.67355005 
               
               
                 201199_s_at 
                 PSMD1 
                 1.03812334 
                 11.768617 
                 3.99425825 
                 0.00018228 
                 0.01820614 
                 0.66050691 
               
               
                 1554691_a_a 
                 PACSIN2 
                 1.05020015 
                 10.5255625 
                 3.98851731 
                 0.00018579 
                 0.01843526 
                 0.64311668 
               
               
                 213503_x_at 
                 ANXA2 
                 1.07802407 
                 12.4262407 
                 3.98512527 
                 0.00018789 
                 0.01856568 
                 0.63284816 
               
               
                 225386_s_at 
                 HNRPLL 
                 1.04770359 
                 11.2270978 
                 3.98475235 
                 0.00018812 
                 0.01856568 
                 0.63171954 
               
               
                 219093_at 
                 FLJ20701 
                 1.14335282 
                 6.49529551 
                 3.98380226 
                 0.00018871 
                 0.01858124 
                 0.62884438 
               
               
                 212657_s_at 
                 IL1RN 
                 1.06064344 
                 10.3261013 
                 3.97849886 
                 0.00019206 
                 0.01881842 
                 0.61280238 
               
               
                 215411_s_at 
                 TRAF3IP2 
                 1.04746131 
                 9.60905229 
                 3.97606781 
                 0.00019361 
                 0.01893656 
                 0.60545275 
               
               
                 224828_at 
                 CPEB4 
                 1.11148606 
                 6.94793798 
                 3.97135657 
                 0.00019665 
                 0.01908993 
                 0.59121672 
               
               
                 208309_s_at 
                 MALT1 
                 1.07563121 
                 7.84016779 
                 3.95900453 
                 0.00020485 
                 0.01975315 
                 0.55393702 
               
               
                 211219_s_at 
                 LHX2 
                 1.07519303 
                 8.41763861 
                 3.95580414 
                 0.00020702 
                 0.01992792 
                 0.54428847 
               
               
                 208619_at 
                 DDB1 
                 1.04094564 
                 10.905059 
                 3.9493717 
                 0.00021147 
                 0.02022705 
                 0.52490916 
               
               
                 212659_s_at 
                 IL1RN 
                 1.06314743 
                 8.36939546 
                 3.94913045 
                 0.00021164 
                 0.02022705 
                 0.52418269 
               
               
                 204401_at 
                 KCNN4 
                 1.0819664 
                 10.2570594 
                 3.94621319 
                 0.00021368 
                 0.02031839 
                 0.51539986 
               
               
                 203922_s_at 
                 CYBB 
                 1.09189933 
                 9.03066782 
                 3.94421507 
                 0.00021509 
                 0.02041722 
                 0.50938632 
               
               
                 225955_at 
                 METRNL ///           
                 1.12640184 
                 9.30736877 
                 3.94080195 
                 0.00021753 
                 0.02054128 
                 0.49911817 
               
               
                 223019_at 
                 C9ORF88 
                 1.11519595 
                 8.77056793 
                 3.93913081 
                 0.00021873 
                 0.02061912 
                 0.49409247 
               
               
                 225372_at 
                 C10ORF54 
                 1.11079316 
                 7.82555013 
                 3.93618776 
                 0.00022086 
                 0.02074849 
                 0.48524461 
               
               
                 225368_at 
                 HIPK2 
                 1.10811883 
                 10.9436109 
                 3.93081197 
                 0.00022481 
                 0.02104628 
                 0.46909267 
               
               
                 227265_at 
                 KIAA1505 
                 1.17158338 
                 9.78973377 
                 3.92552212 
                 0.00022875 
                 0.02130693 
                 0.45321112 
               
               
                 238604_at 
                 ECOP 
                 1.07570947 
                 9.50546921 
                 3.92153082 
                 0.00023178 
                 0.02151518 
                 0.44123614 
               
               
                 206171_at 
                 ADORA3 
                 1.12468497 
                 8.70914475 
                 3.92097723 
                 0.0002322 
                 0.02151785 
                 0.43957576 
               
               
                 200748_s_at 
                 FTH1 
                 1.09484808 
                 13.0211632 
                 3.91978982 
                 0.00023311 
                 0.02156547 
                 0.43601482 
               
               
                 204858_s_at 
                 ECGF1 
                 1.07328226 
                 10.0994132 
                 3.91907356 
                 0.00023366 
                 0.0215798 
                 0.43386711 
               
               
                 226534_at 
                 KITLG 
                 1.07330296 
                 9.3627121 
                 3.90512624 
                 0.00024461 
                 0.02229014 
                 0.3920904 
               
               
                 225407_at 
                 MBP 
                 1.05793961 
                 11.3278556 
                 3.90258448 
                 0.00024666 
                 0.02243941 
                 0.38448614 
               
               
                 216594_x_at 
                 AKR1C1 
                 1.08731511 
                 8.97660025 
                 3.90054274 
                 0.00024832 
                 0.02255267 
                 0.37837983 
               
               
                 242157_at 
                 — 
                 1.10450816 
                 7.85915836 
                 3.89900755 
                 0.00024957 
                 0.02262757 
                 0.37378967 
               
               
                 203104_at 
                 CSF1R 
                 1.066843 
                 11.2558738 
                 3.89852024 
                 0.00024997 
                 0.02262757 
                 0.37233286 
               
               
                 201471_s_at 
                 SQSTM1 
                 1.06817603 
                 11.064824 
                 3.8911549 
                 0.00025608 
                 0.02302792 
                 0.35032669 
               
               
                 201565_s_at 
                 ID2 
                 1.05840108 
                 12.351258 
                 3.88999177 
                 0.00025705 
                 0.02306893 
                 0.34685365 
               
               
                 201412_at 
                 LRP10 
                 1.0522513 
                 10.0558306 
                 3.8879203 
                 0.0002588 
                 0.0231589 
                 0.34066984 
               
               
                 208982_at 
                 PECAM1 
                 1.04940273 
                 12.4408294 
                 3.88579521 
                 0.00026061 
                 0.02324451 
                 0.33432794 
               
               
                 242302_at 
                 APRIN 
                 1.09399636 
                 6.08366862 
                 3.88405566 
                 0.0002621 
                 0.02333917 
                 0.32913805 
               
               
                 201920_at 
                 SLC20A1 
                 1.0505388 
                 11.1251381 
                 3.87844015 
                 0.00026696 
                 0.02365634 
                 0.31239348 
               
               
                 214084_x_at 
                 LOC648998 /           
                 1.07297813 
                 9.87462439 
                 3.87717059 
                 0.00026807 
                 0.02367801 
                 0.30860978 
               
               
                 202804_at 
                 ABCC1 
                 1.05325862 
                 10.0332207 
                 3.86552597 
                 0.00027847 
                 0.02439924 
                 0.27393816 
               
               
                 228532_at 
                 C1ORF162 
                 1.06940145 
                 10.9010812 
                 3.86494651 
                 0.00027899 
                 0.02440633 
                 0.2722144 
               
               
                 210773_s_at 
                 FPRL1 
                 1.096511 
                 8.0656375 
                 3.86209224 
                 0.0002816 
                 0.02456545 
                 0.26372575 
               
               
                 204620_s_at 
                 CSPG2 
                 1.09556927 
                 10.356296 
                 3.85613369 
                 0.00028713 
                 0.02491902 
                 0.24601655 
               
               
                 227067_x_at 
                 NOTCH2NL 
                 1.0532533 
                 10.0530487 
                 3.85320299 
                 0.00028989 
                 0.02507868 
                 0.23731212 
               
               
                 226368_at 
                 CHST11 
                 1.07195471 
                 9.52648879 
                 3.8487656 
                 0.00029411 
                 0.02532955 
                 0.22413996 
               
               
                 213142_x_at 
                 LOC54103 
                 1.06311548 
                 10.4211815 
                 3.84869575 
                 0.00029418 
                 0.02532955 
                 0.22393268 
               
               
                 217992_s_at 
                 EFHD2 
                 1.06506856 
                 11.6374518 
                 3.84358776 
                 0.00029911 
                 0.02567362 
                 0.20878091 
               
               
                 221571_at 
                 TRAF3 
                 1.06383739 
                 9.65844518 
                 3.84232271 
                 0.00030035 
                 0.02570473 
                 0.20503022 
               
               
                 225207_at 
                 PDK4 
                 1.13997001 
                 6.99602651 
                 3.84205117 
                 0.00030061 
                 0.02570473 
                 0.20422522 
               
               
                 201191_at 
                 PITPNA 
                 1.07930886 
                 8.54956136 
                 3.83764717 
                 0.00030495 
                 0.02584057 
                 0.19117405 
               
               
                 219412_at 
                 RAB38 
                 1.09786171 
                 8.08626906 
                 3.83442124 
                 0.00030817 
                 0.02600194 
                 0.18161959 
               
               
                 50221_at 
                 TFEB 
                 1.06697604 
                 9.57832583 
                 3.83038439 
                 0.00031224 
                 0.02622405 
                 0.16966997 
               
               
                 206140_at 
                 LHX2 
                 1.06574569 
                 9.81614566 
                 3.82420766 
                 0.00031857 
                 0.02659987 
                 0.15140014 
               
               
                 226545_at 
                 CD109 
                 1.07280592 
                 9.51243783 
                 3.82411952 
                 0.00031866 
                 0.02659987 
                 0.15113954 
               
               
                 1552486_s_a 
                 LACTB 
                 1.08525899 
                 8.38629859 
                 3.82306652 
                 0.00031975 
                 0.0266503 
                 0.1480267 
               
               
                 228368_at 
                 ARHGAP2O 
                 1.14164081 
                 7.83168691 
                 3.81871004 
                 0.00032431 
                 0.02696861 
                 0.13515348 
               
               
                 238727_at 
                 LOC440934 
                 1.11497925 
                 7.08620645 
                 3.8125927 
                 0.00033081 
                 0.02730892 
                 0.11709143 
               
               
                 225283_at 
                 ARRDC4 
                 1.04969035 
                 9.71669678 
                 3.8080796 
                 0.00033569 
                 0.02759937 
                 0.10377692 
               
               
                 201995_at 
                 EXT1 
                 1.09076481 
                 6.49400167 
                 3.80540237 
                 0.00033861 
                 0.02779804 
                 0.09588293 
               
               
                 231496_at 
                 FCAMR 
                 1.09935645 
                 7.04227829 
                 3.79899562 
                 0.00034571 
                 0.02829583 
                 0.07700546 
               
               
                 217741_s_at 
                 ZFAND5 
                 1.03867699 
                 11.247246 
                 3.79602954 
                 0.00034904 
                 0.02848348 
                 0.06827223 
               
               
                 226075_at 
                 SPSB1 
                 1.09367375 
                 6.41796675 
                 3.79131798 
                 0.0003544 
                 0.02879199 
                 0.0544079 
               
               
                 1569136_at 
                 MGAT4A 
                 1.18908532 
                 6.30607913 
                 3.78721234 
                 0.00035914 
                 0.02909023 
                 0.04233483 
               
               
                 AFFX-HUMIS           
                 STAT1 
                 1.06320305 
                 9.76660865 
                 3.78614824 
                 0.00036038 
                 0.02914726 
                 0.03920699 
               
               
                 206157_at 
                 PTX3 
                 1.13951692 
                 9.77811771 
                 3.77291403 
                 0.00037611 
                 0.02998389 
                 0.00034936 
               
               
                 204899_s_at 
                 SAP30 
                 1.05454489 
                 9.10790083 
                 3.7723175 
                 0.00037683 
                 0.02998389 
                 −0.0014002 
               
               
                 210427_x_at 
                 ANXA2 
                 1.07331631 
                 12.5352054 
                 3.77202707 
                 0.00037719 
                 0.02398389 
                 −0.002252 
               
               
                 210357_s_at 
                 SMOX 
                 1.08311104 
                 8.03967009 
                 3.7719322 
                 0.0003773 
                 0.02998389 
                 −0.0025302 
               
               
                 225530_at 
                 MOBKL2A 
                 1.04391552 
                 10.5141996 
                 3.76923042 
                 0.0003806 
                 0.03009487 
                 −0.010452 
               
               
                 234976_x_at 
                 SLC4A5 
                 1.0654205 
                 8.11158064 
                 3.76817676 
                 0.0003819 
                 0.03011937 
                 −0.0135404 
               
               
                 225115_at 
                 HIPK2 
                 1.08936992 
                 8.35503513 
                 3.76532698 
                 0.00038542 
                 0.03026716 
                 −0.0218911 
               
               
                 212561_at 
                 RAB6IP1 
                 1.05486737 
                 10.6169658 
                 3.76463655 
                 0.00038628 
                 0.03026716 
                 −0.0239136 
               
               
                 233177_s_at 
                 PNKD 
                 1.05881097 
                 8.90692004 
                 3.7603318 
                 0.00039167 
                 0.03054886 
                 −0.0365193 
               
               
                 205926_at 
                 IL27RA 
                 1.08811794 
                 8.50082949 
                 3.75788045 
                 0.00039478 
                 0.03074707 
                 −0.0436938 
               
               
                 203940_s_at 
                 VASH1 
                 1.10205097 
                 8.93929781 
                 3.75557481 
                 0.00039772 
                 0.03085591 
                 −0.0504392 
               
               
                 230634_x_at 
                 LOC113179 
                 1.06907966 
                 7.85469698 
                 3.75508795 
                 0.00039834 
                 0.03085591 
                 −0.0518633 
               
               
                 219994_at 
                 APBB1IP 
                 1.07862342 
                 8.79352106 
                 3.75501728 
                 0.00039843 
                 0.03085591 
                 −0.05207 
               
               
                 211139_s_at 
                 NAB1 
                 1.07131493 
                 8.72031957 
                 3.74646937 
                 0.00040954 
                 0.0314976 
                 −0.0770544 
               
               
                 201707_at 
                 PEX19 
                 1.04709872 
                 10.5748471 
                 3.74254693 
                 0.00041473 
                 0.03166964 
                 −0.0885078 
               
               
                 209933_s_at 
                 CD300A 
                 1.06497364 
                 9.72572801 
                 3.74177958 
                 0.00041576 
                 0.03168935 
                 −0.0907476 
               
               
                 203233_at 
                 IL4R 
                 1.07541642 
                 8.96600019 
                 3.74112983 
                 0.00041662 
                 0.03168935 
                 −0.092644 
               
               
                 212724_at 
                 RND3 
                 1.10102105 
                 7.85276337 
                 3.73595709 
                 0.0004236 
                 0.03207812 
                 −0.1077338 
               
               
                 218260_at 
                 C19ORF58 
                 1.05658126 
                 9.52851985 
                 3.72698571 
                 0.00043597 
                 0.03278903 
                 −0.1338755 
               
               
                 202779_s_at 
                 UBE2S /// L           
                 1.03653716 
                 12.7522175 
                 3.71585925 
                 0.00045179 
                 0.03383761 
                 −0.1662444 
               
               
                 204589_at 
                 NUAK1 
                 1.08993672 
                 6.70389618 
                 3.71372502 
                 0.00045488 
                 0.0339596 
                 −0.1724466 
               
               
                 200078_s_at 
                 ATP6V0B 
                 1.0264003 
                 13.5385773 
                 3.71309911 
                 0.0004558 
                 0.0339596 
                 −0.1742651 
               
               
                 202192_s_at 
                 GAS7 
                 1.07358071 
                 9.32496946 
                 3.71302712 
                 0.0004559 
                 0.0339596 
                 −0.1744742 
               
               
                 242705_x_at 
                 — 
                 1.050541 
                 9.41748882 
                 3.71038947 
                 0.00045976 
                 0.03410795 
                 −0.1821356 
               
               
                 218611_at 
                 IER5 
                 1.07040021 
                 11.1112341 
                 3.70562135 
                 0.00046683 
                 0.0343816 
                 −0.1959768 
               
               
                 239598_s_at 
                 AYTL1 
                 1.0605954 
                 9.78054544 
                 3.70535414 
                 0.00046723 
                 0.0343816 
                 −0.1967522 
               
               
                 219456_s_at 
                 RIN3 
                 1.07330011 
                 7.90448799 
                 3.70257871 
                 0.00047139 
                 0.03464126 
                 −0.2048036 
               
               
                 211572_s_at 
                 SLC23A2 
                 1.07618941 
                 7.04729666 
                 3.70142012 
                 0.00047314 
                 0.03470886 
                 −0.2081635 
               
               
                 212502_at 
                 C10ORF22 
                 1.04307648 
                 9.95312582 
                 3.70033342 
                 0.00047478 
                 0.03475049 
                 −0.2113144 
               
               
                 201251_at 
                 PKM2 
                 1.04329421 
                 13.0859336 
                 3.69894945 
                 0.00047688 
                 0.03485776 
                 −0.2153264 
               
               
                 204135_at 
                 DOC1 
                 1.07274599 
                 8.83386998 
                 3.69578905 
                 0.00048172 
                 0.03516424 
                 −0.2244847 
               
               
                 219944_at 
                 RSNL2 
                 1.08504226 
                 7.05512921 
                 3.69481629 
                 0.00048322 
                 0.03517085 
                 −0.2273027 
               
               
                 210018_x_at 
                 MALT1 
                 1.06841222 
                 7.99947523 
                 3.69389329 
                 0.00048464 
                 0.03517085 
                 −0.229976 
               
               
                 236220_at 
                 — 
                 1.14920843 
                 4.26492324 
                 3.69312582 
                 0.00048583 
                 0.03517085 
                 −0.2321986 
               
               
                 213935_at 
                 ABHD5 
                 1.07822608 
                 6.87154542 
                 3.69294217 
                 0.00048612 
                 0.03517085 
                 −0.2327305 
               
               
                 227420_at 
                 TNFAIP8L1 
                 1.06654551 
                 8.06189779 
                 3.69281506 
                 0.00048631 
                 0.03517085 
                 −0.2330985 
               
               
                 219496_at 
                 ANKRD57 
                 1.13993106 
                 6.53387141 
                 3.6910586 
                 0.00048905 
                 0.03532176 
                 −0.2381839 
               
               
                 214743_at 
                 CUTL1 
                 1.06965625 
                 9.94412122 
                 3.68791266 
                 0.00049398 
                 0.0355839 
                 −0.2472886 
               
               
                 1554544_a_a 
                 MBP 
                 1.07318708 
                 10.1607524 
                 3.6870054 
                 0.00049541 
                 0.03564002 
                 −0.2499134 
               
               
                 218614_at 
                 C12ORF35 
                 1.06691348 
                 10.0756991 
                 3.68269534 
                 0.00050226 
                 0.03608547 
                 −0.2623776 
               
               
                 205147_x_at 
                 NCF4 
                 1.03578282 
                 11.8404339 
                 3.6799098 
                 0.00050674 
                 0.03617329 
                 −0.2704283 
               
               
                 223852_s_at 
                 STK40 
                 1.07352861 
                 8.47342374 
                 3.67987641 
                 0.00050679 
                 0.03617329 
                 −0.2705248 
               
               
                 204834_at 
                 FGL2 
                 1.15453451 
                 8.63307396 
                 3.67701847 
                 0.00051142 
                 0.03645638 
                 −0.2787809 
               
               
                 36994_at 
                 ATP6V0C 
                 1.03052612 
                 13.09078 
                 3.6758467 
                 0.00051333 
                 0.03649744 
                 −0.2821648 
               
               
                 1555168_a_a 
                 CALN1 
                 1.07042924 
                 7.3789421 
                 3.66717734 
                 0.00052769 
                 0.03716608 
                 −0.3071804 
               
               
                 203388_at 
                 ARRB2 
                 1.05764941 
                 9.38740578 
                 3.66559438 
                 0.00053035 
                 0.03717544 
                 −0.3117441 
               
               
                 214054_at 
                 DOK2 
                 1.07678197 
                 11.2259885 
                 3.66223375 
                 0.00053604 
                 0.03752644 
                 −0.321429 
               
               
                 212096_s_at 
                 MTUS1 
                 1.11473269 
                 7.49260762 
                 3.6528896 
                 0.00055218 
                 0.03845937 
                 −0.3483291 
               
               
                 225480_at 
                 C1ORF122 
                 1.04930018 
                 10.1940995 
                 3.65080013 
                 0.00055586 
                 0.03866588 
                 −0.3543385 
               
               
                 201700_at 
                 CCND3 
                 1.04752925 
                 12.8929574 
                 3.64778851 
                 0.00056119 
                 0.03888847 
                 −0.3629964 
               
               
                 218399_s_at 
                 CDCA4 
                 1.03865826 
                 10.9812294 
                 3.64588211 
                 0.00056459 
                 0.03907466 
                 −0.3684747 
               
               
                 212003_at 
                 C1ORF144 
                 1.05223728 
                 9.96851324 
                 3.64185086 
                 0.00057185 
                 0.03942724 
                 −0.3800532 
               
               
                 205099_s_at 
                 CCR1 
                 1.07264855 
                 9.06024264 
                 3.63132179 
                 0.00059123 
                 0.04045726 
                 −0.4102577 
               
               
                 201422_at 
                 IFI30 
                 1.05859805 
                 11.1928984 
                 3.63012447 
                 0.00059347 
                 0.04050934 
                 −0.413689 
               
               
                 227220_at 
                 NFXL1 
                 1.06892434 
                 8.69171722 
                 3.62491347 
                 0.00060333 
                 0.04097752 
                 −0.4286146 
               
               
                 213923_at 
                 RAP2B 
                 1.05181562 
                 11.5158708 
                 3.62050346 
                 0.00061179 
                 0.04138559 
                 −0.4412357 
               
               
                 242538_at 
                 TFDP1 
                 1.06598341 
                 8.25495776 
                 3.61714555 
                 0.00061831 
                 0.04163319 
                 −0.4508394 
               
               
                 211855_s_at 
                 SLC25A14 
                 1.04783376 
                 8.87468082 
                 3.61205543 
                 0.00062832 
                 0.04220328 
                 −0.4653867 
               
               
                 205462_s_at 
                 HPCAL1 
                 1.0537572 
                 10.6818738 
                 3.60669792 
                 0.00063902 
                 0.04273699 
                 −0.4806845 
               
               
                 213649_at 
                 SFRS7 
                 1.10439275 
                 9.36601754 
                 3.60651451 
                 0.00063939 
                 0.04273699 
                 −0.4812079 
               
               
                 225701_at 
                 AKNA 
                 1.052602 
                 8.96472073 
                 3.60207226 
                 0.00064841 
                 0.04315666 
                 −0.4938812 
               
               
                 217691_x_at 
                 SLC16A3 
                 1.06195853 
                 9.25873814 
                 3.60186431 
                 0.00064883 
                 0.04315666 
                 −0.4944742 
               
               
                 225375_at 
                 C17ORF32 
                 1.04600249 
                 10.3975791 
                 3.59958371 
                 0.00065351 
                 0.04336219 
                 −0.5009765 
               
               
                 206710_s_at 
                 EPB41L3 
                 1.10596585 
                 7.40730158 
                 3.59798029 
                 0.00065681 
                 0.04347608 
                 −0.5055465 
               
               
                 204393_s_at 
                 ACPP 
                 1.05975941 
                 8.04387684 
                 3.59438387 
                 0.00066429 
                 0.04381176 
                 −0.5157924 
               
               
                 244536_at 
                 TP53BP2 
                 1.18627513 
                 7.50015327 
                 3.58918064 
                 0.00067525 
                 0.04421781 
                 −0.5306045 
               
               
                 219183_s_at 
                 PSCD4 
                 1.04907356 
                 10.1644303 
                 3.58716888 
                 0.00067953 
                 0.04438865 
                 −0.5363279 
               
               
                 226267_at 
                 JDP2 
                 1.0662635 
                 8.31398002 
                 3.5828349 
                 0.00068885 
                 0.04454185 
                 −0.548651 
               
               
                 202111_at 
                 SLC4A2 
                 1.06505371 
                 9.07129828 
                 3.58192152 
                 0.00069082 
                 0.04454185 
                 −0.5512469 
               
               
                 205128_x_at 
                 PTGS1 
                 1.05569773 
                 10.4322081 
                 3.58162573 
                 0.00069147 
                 0.04454185 
                 −0.5520875 
               
               
                 227107_at 
                 — 
                 1.05069658 
                 9.99172727 
                 3.57890951 
                 0.00069739 
                 0.0448057 
                 −0.5598043 
               
               
                 204489_s_at 
                 CD44 
                 1.06303314 
                 10.62276 
                 3.57845421 
                 0.00069838 
                 0.04481711 
                 −0.5610975 
               
               
                 224733_at 
                 CMTM3 
                 1.05905507 
                 10.6346875 
                 3.57586316 
                 0.00070409 
                 0.04507716 
                 −0.5684547 
               
               
                 229045_at 
                 SLIC1 
                 1.07967634 
                 7.89386361 
                 3.57233315 
                 0.00071192 
                 0.04541946 
                 −0.5784727 
               
               
                 242414_at 
                 QPRT 
                 1.05189094 
                 10.2463166 
                 3.56946163 
                 0.00071836 
                 0.04561726 
                 −0.5866174 
               
               
                 227948_at 
                 FGD4 
                 1.09161868 
                 7.2001949 
                 3.55996253 
                 0.00074006 
                 0.04665922 
                 −0.6135311 
               
               
                 207610_s_at 
                 EMR2 
                 1.10912425 
                 6.51140397 
                 3.55918695 
                 0.00074185 
                 0.04665922 
                 −0.6157265 
               
               
                 238389_s_at 
                 — 
                 1.08307842 
                 8.36785016 
                 3.55808073 
                 0.00074443 
                 0.04672969 
                 −0.6188574 
               
               
                 202295_s_at 
                 CTSH 
                 1.0545204 
                 12.0343467 
                 3.55490548 
                 0.00075186 
                 0.04706777 
                 −0.6278407 
               
               
                 213134_x_at 
                 BTG3 
                 1.04181201 
                 11.0553855 
                 3.55329658 
                 0.00075565 
                 0.04706777 
                 −0.6323906 
               
               
                 204495_s_at 
                 C15ORF39 
                 1.06073223 
                 9.19429662 
                 3.55321693 
                 0.00075584 
                 0.04706777 
                 −0.6326159 
               
               
                 225631_at 
                 KIAA1706 
                 1.09137745 
                 7.01050123 
                 3.55021925 
                 0.00076296 
                 0.04734911 
                 −0.6410896 
               
               
                 217168_s_at 
                 HERPUD1 
                 1.03983791 
                 11.6835542 
                 3.54664359 
                 0.00077153 
                 0.04764859 
                 −0.6511914 
               
               
                 203658_at 
                 SLC25A20 
                 1.04561479 
                 9.46245075 
                 3.54654461 
                 0.00077177 
                 0.04764859 
                 −0.6514709 
               
               
                 226735_at 
                 FLJ90013 
                 1.05055665 
                 9.2921795 
                 3.54448273 
                 0.00077675 
                 0.04781967 
                 −0.657293 
               
               
                 212372_at 
                 MYH10 
                 1.06171907 
                 9.0082261 
                 3.53720879 
                 0.00079459 
                 0.04864948 
                 −0.6778151 
               
               
                 214769_at 
                 — 
                 1.06476746 
                 8.52685941 
                 3.53521138 
                 0.00079955 
                 0.04873518 
                 −0.6834457 
               
               
                 225408_at 
                 MBP 
                 1.0628553 
                 8.95772417 
                 3.53415379 
                 0.00080219 
                 0.04881373 
                 −0.6864262 
               
               
                 222900_at 
                 — 
                 1.05686661 
                 9.96719959 
                 3.53260926 
                 0.00080606 
                 0.04891403 
                 −0.690778 
               
               
                 1562475_at 
                 DKFZP686O1 
                 1.08348486 
                 8.1338617 
                 3.53084868 
                 0.0008105 
                 0.04912864 
                 −0.6957371 
               
               
                 226629_at 
                 SLC43A2 
                 1.09818747 
                 7.92209671 
                 3.5269652 
                 0.00082036 
                 0.04956322 
                 −0.7066702 
               
               
                 204174_at 
                 ALOX5AP 
                 1.04445917 
                 12.5979593 
                 3.52653085 
                 0.00082147 
                 0.04956322 
                 −0.7078925 
               
               
                 211067_s_at 
                 GAS7 
                 1.06066251 
                 9.58135451 
                 3.52629694 
                 0.00082207 
                 0.04956322 
                 −0.7085508 
               
               
                 204157_s_at 
                 KIAA0999 
                 1.06020492 
                 8.89537432 
                 3.52624693 
                 0.0008222 
                 0.04956322 
                 −0.7086915 
               
               
                 211026_s_at 
                 MGLL 
                 1.05773402 
                 7.85103089 
                 3.52322146 
                 0.00082998 
                 0.04986733 
                 −0.7172027 
               
               
                 204614_at 
                 SERPINB2 
                 −1.1647768 
                 12.4744252 
                 −7.4528925 
                 4.60E−10 
                 9.68E−07 
                 12.5679641 
               
               
                 211421_s_at 
                 RET 
                 −1.1345252 
                 9.80328848 
                 −7.1113218 
                 1.75E−09 
                 3.41E−06 
                 11.3371247 
               
               
                 207725_at 
                 POU4F2 
                 −1.1644052 
                 9.97790101 
                 −6.9339707 
                 3.49E−09 
                 6.15E−06 
                 10.6980464 
               
               
                 208206_s_at 
                 RASGRP2 
                 −1.1124445 
                 10.5120774 
                 −6.549181 
                 1.56E−08 
                 1.82E−05 
                 9.31420762 
               
               
                 218971_s_at 
                 HSPC049 
                 −1.1502366 
                 9.26509596 
                 −6.353404 
                 3.32E−08 
                 3.04E−05 
                 8.6128924 
               
               
                 222799_at 
                 HSPC049 
                 −1.1678019 
                 8.76549992 
                 −6.2405739 
                 5.13E−08 
                 4.25E−05 
                 8.20995923 
               
               
                 219463_at 
                 C20ORF103 
                 −1.1066514 
                 11.1578088 
                 −6.1792066 
                 6.49E−08 
                 5.22E−05 
                 7.99126082 
               
               
                 218858_at 
                 DEPDC6 
                 −1.1739709 
                 8.39313128 
                 −6.1048654 
                 8.64E−08 
                 6.72E−05 
                 7.72680015 
               
               
                 214539_at 
                 SERPINB10 
                 −1.1393961 
                 9.05047781 
                 −6.0524221 
                 1.06E−07 
                 7.91E−05 
                 7.54057412 
               
               
                 225510_at 
                 OAF 
                 −1.0795282 
                 10.1352866 
                 −5.9010298 
                 1.88E−07 
                 0.00012109 
                 7.0047035 
               
               
                 228855_at 
                 LOC645919 
                 −1.1276666 
                 10.7515984 
                 −5.8846827 
                 2.00E−07 
                 0.0001259 
                 6.94700615 
               
               
                 200799_at 
                 HSPA1A 
                 −1.0946162 
                 10.8594511 
                 −5.7859004 
                 2.92E−07 
                 0.00016854 
                 6.59909626 
               
               
                 206643_at 
                 HAL 
                 −1.1136035 
                 9.45516733 
                 −5.7636924 
                 3.17E−07 
                 0.000177 
                 6.52106329 
               
               
                 44790_s_at 
                 C13ORF18 
                 −1.1118604 
                 11.1923769 
                 −5.7586514 
                 3.23E−07 
                 0.00017859 
                 6.50336066 
               
               
                 202441_at 
                 SPFH1 
                 −1.0851805 
                 11.4291926 
                 −5.6315658 
                 5.23E−07 
                 0.00025521 
                 6.05830953 
               
               
                 206034_at 
                 SERPINB8 
                 −1.080288 
                 10.6134257 
                 −5.5518212 
                 7.06E−07 
                 0.00032156 
                 5.78034465 
               
               
                 203685_at 
                 BCL2 
                 −1.1572394 
                 9.68186938 
                 −5.5344339 
                 7.53E−07 
                 0.00034041 
                 5.71987917 
               
               
                 216733_s_at 
                 GATM 
                 −1.0919977 
                 10.6962606 
                 −5.5025531 
                 8.49E−07 
                 0.00037436 
                 5.60914785 
               
               
                 224428_s_at 
                 CDCA7 
                 −1.0723261 
                 11.8097904 
                 −5.4896239 
                 8.91E−07 
                 0.0003867 
                 5.56429181 
               
               
                 201310_s_at 
                 C5ORF13 
                 −1.1126729 
                 11.785614 
                 −5.4263444 
                 1.13E−06 
                 0.00045596 
                 5.34518848 
               
               
                 213361_at 
                 TDRD7 
                 −1.1610606 
                 10.9747672 
                 −5.391919 
                 1.28E−06 
                 0.00050496 
                 5.22630402 
               
               
                 219714_s_at 
                 CACNA2D3 
                 −1.0949691 
                 10.9314712 
                 −5.3685146 
                 1.40E−06 
                 0.00054258 
                 5.14560908 
               
               
                 35974_at 
                 LRMP 
                 −1.1227255 
                 8.47924836 
                 −5.3181301 
                 1.69E−06 
                 0.00062826 
                 4.97225553 
               
               
                 201309_x_at 
                 C5ORF13 
                 −1.1203829 
                 9.89153948 
                 −5.2776918 
                 1.96E−06 
                 0.00070587 
                 4.83349392 
               
               
                 243824_at 
                 — 
                 −1.1826717 
                 8.98902905 
                 −5.2561294 
                 2.13E−06 
                 0.00073085 
                 4.75964206 
               
               
                 226117_at 
                 TIFA 
                 −1.0706362 
                 10.6431699 
                 −5.2203927 
                 2.43E−06 
                 0.0008154 
                 4.63745968 
               
               
                 210986_s_at 
                 TPM1 
                 −1.0953979 
                 11.1982 
                 −5.1779859 
                 2.84E−06 
                 0.00090145 
                 4.49283173 
               
               
                 235275_at 
                 OXCT2 
                 −1.167218 
                 12.4747234 
                 −5.1258467 
                 3.43E−06 
                 0.0010376 
                 4.31556088 
               
               
                 203178_at 
                 GATM 
                 −1.1772979 
                 9.84150408 
                 −5.0826986 
                 4.02E−06 
                 0.00116392 
                 4.16933171 
               
               
                 223062_s_at 
                 PSAT1 
                 −1.0966737 
                 10.8142971 
                 −5.0731123 
                 4.17E−06 
                 0.00119913 
                 4.13690304 
               
               
                 227921_at 
                 — 
                 −1.0939212 
                 9.03183919 
                 −5.0296725 
                 4.88E−06 
                 0.00137633 
                 3.99023064 
               
               
                 225673_at 
                 MYADM 
                 −1.0710199 
                 12.4026311 
                 −5.0110829 
                 5.23E−06 
                 0.00143582 
                 3.92760413 
               
               
                 210987_x_at 
                 TPM1 
                 −1.0747681 
                 11.0724469 
                 −5.008451 
                 5.28E−06 
                 0.0014424 
                 3.91874425 
               
               
                 220252_x_at 
                 CXORF21 
                 −1.1107929 
                 11.2367599 
                 −4.990621 
                 5.63E−06 
                 0.00153146 
                 3.85876875 
               
               
                 212175_s_at 
                 AK2 
                 −1.0635824 
                 12.0939996 
                 −4.9479609 
                 6.57E−06 
                 0.00172797 
                 3.71559637 
               
               
                 213931_at 
                 ID2 /// ID2B 
                 −1.5575806 
                 8.63155658 
                 −4.8451866 
                 9.53E−06 
                 0.00231585 
                 3.37261839 
               
               
                 206116_s_at 
                 TPM1 
                 −1.0886322 
                 10.541027 
                 −4.8397732 
                 9.72E−06 
                 0.00235097 
                 3.35463151 
               
               
                 225421_at 
                 ACY1L2 
                 −1.1026709 
                 10.2401371 
                 −4.8246433 
                 1.03E−05 
                 0.00244373 
                 3.30440211 
               
               
                 228188_at 
                 — 
                 −1.0980344 
                 9.30046163 
                 −4.8130876 
                 1.07E−05 
                 0.00252076 
                 3.26608136 
               
               
                 1553436_at 
                 MUC19 
                 −1.1317348 
                 7.84569387 
                 −4.796243 
                 1.14E−05 
                 0.00260733 
                 3.21028822 
               
               
                 223165_s_at 
                 IHPK2 
                 −1.0812006 
                 8.49238402 
                 −4.7744158 
                 1.23E−05 
                 0.00276466 
                 3.13811043 
               
               
                 217521_at 
                 — 
                 −1.0843722 
                 8.45544985 
                 −4.7662509 
                 1.27E−05 
                 0.00282288 
                 3.11114575 
               
               
                 214787_at 
                 DENND4A 
                 −1.1130314 
                 8.79367689 
                 −4.743088 
                 1.37E−05 
                 0.00298199 
                 3.03475381 
               
               
                 212765_at 
                 CAMSAP1L1 
                 −1.0863982 
                 9.42505575 
                 −4.7345547 
                 1.42E−05 
                 0.0030621 
                 3.00664977 
               
               
                 210254_at 
                 MS4A3 
                 −1.0500477 
                 12.8157054 
                 −4.7261168 
                 1.46E−05 
                 0.00314327 
                 2.9788805 
               
               
                 233176_at 
                 — 
                 −1.1278256 
                 8.19196857 
                 −4.7198778 
                 1.49E−05 
                 0.00318888 
                 2.95836149 
               
               
                 223344_s_at 
                 MS4A7 
                 −1.0542376 
                 11.6140787 
                 −4.6615341 
                 1.84E−05 
                 0.00376871 
                 2.7670363 
               
               
                 219951_s_at 
                 C20ORF12 
                 −1.0986972 
                 9.36939485 
                 −4.6610806 
                 1.84E−05 
                 0.00376871 
                 2.76555328 
               
               
                 224358_s_at 
                 MS4A7 
                 −1.0737805 
                 10.2934393 
                 −4.6288589 
                 2.06E−05 
                 0.00414687 
                 2.66033365 
               
               
                 209822_s_at 
                 VLDLR 
                 −1.0809314 
                 10.4822858 
                 −4.6256973 
                 2.09E−05 
                 0.00417816 
                 2.65002641 
               
               
                 1554892_a_a 
                 MS4A3 
                 −1.0607494 
                 11.9760309 
                 −4.6180329 
                 2.14E−05 
                 0.00427729 
                 2.62505295 
               
               
                 224916_at 
                 LOC340061 
                 −1.0659077 
                 11.5293213 
                 −4.6084907 
                 2.22E−05 
                 0.00435798 
                 2.59398619 
               
               
                 219607_s_at 
                 MS4A4A 
                 −1.0618962 
                 10.8982797 
                 −4.6084529 
                 2.22E−05 
                 0.00435798 
                 2.59386325 
               
               
                 220112_at 
                 ANKRD55 
                 −1.0892108 
                 8.61196167 
                 −4.6022914 
                 2.27E−05 
                 0.00439877 
                 2.57381817 
               
               
                 202158_s_at 
                 CUGBP2 
                 −1.071327 
                 10.2596168 
                 −4.5821696 
                 2.43E−05 
                 0.00466718 
                 2.50843969 
               
               
                 229638_at 
                 IRX3 
                 −1.0842058 
                 12.4826855 
                 −4.5731157 
                 2.51E−05 
                 0.00474087 
                 2.47906391 
               
               
                 1557359_at 
                 LOC285758 
                 −1.0922204 
                 9.92033734 
                 −4.5727867 
                 2.51E−05 
                 0.00474087 
                 2.47799688 
               
               
                 1555037_a_a 
                 IDH1 
                 −1.0626668 
                 11.297782 
                 −4.562743 
                 2.61E−05 
                 0.00479572 
                 2.4454411 
               
               
                 235936_at 
                 LOC254559 
                 −1.0942156 
                 7.69992263 
                 −4.5533045 
                 2.69E−05 
                 0.0048917 
                 2.41487632 
               
               
                 217196_s_at 
                 CAMSAP1L1 
                 −1.0905855 
                 8.32441354 
                 −4.5428721 
                 2.79E−05 
                 0.0050078 
                 2.38112639 
               
               
                 225786_at 
                 LOC284702 
                 −1.1841367 
                 9.55400971 
                 −4.510983 
                 3.12E−05 
                 0.00541251 
                 2.27818048 
               
               
                 203221_at 
                 TLE1 
                 −1.0725652 
                 10.2194004 
                 −4.504306 
                 3.20E−05 
                 0.00551587 
                 2.25606737 
               
               
                 218507_at 
                 HIG2 
                 −1.0603259 
                 10.2529741 
                 −4.4729944 
                 3.57E−05 
                 0.0059656 
                 2.1559794 
               
               
                 223952_x_at 
                 DHRS9 
                 −1.0842606 
                 12.9366028 
                 −4.4456627 
                 3.92E−05 
                 0.00631099 
                 2.0683571 
               
               
                 224929_at 
                 LOC340061 
                 −1.0551654 
                 11.6690807 
                 −4.4386464 
                 4.02E−05 
                 0.00644802 
                 2.04590464 
               
               
                 209485_s_at 
                 OSBPL1A 
                 −1.0832594 
                 8.89666819 
                 −4.4376043 
                 4.04E−05 
                 0.00645252 
                 2.04257108 
               
               
                 222369_at 
                 NAT11 
                 −1.0773853 
                 9.63846481 
                 −4.4294999 
                 4.15E−05 
                 0.00661759 
                 2.01666018 
               
               
                 210279_at 
                 GPR18 
                 −1.1061684 
                 9.71898614 
                 −4.4206221 
                 4.28E−05 
                 0.00676572 
                 1.98830241 
               
               
                 206542_s_at 
                 SMARCA2 
                 −1.0665392 
                 10.093152 
                 −4.4164022 
                 4.34E−05 
                 0.00682612 
                 1.97483232 
               
               
                 228055_at 
                 NAPSB 
                 −1.1406853 
                 10.0636876 
                 −4.411431 
                 4.42E−05 
                 0.00690524 
                 1.95897232 
               
               
                 206088_at 
                 LOC474170 
                 −1.1642536 
                 5.60881351 
                 −4.3987993 
                 4.62E−05 
                 0.00715313 
                 1.91871021 
               
               
                 1555728_a_a 
                 MS4A4A 
                 −1.0619928 
                 10.814275 
                 −4.3884831 
                 4.79E−05 
                 0.00739242 
                 1.8858698 
               
               
                 229159_at 
                 KIAA0960 
                 −1.1638873 
                 7.81943811 
                 −4.378427 
                 4.96E−05 
                 0.00756868 
                 1.85389295 
               
               
                 212071_s_at 
                 SPTBN1 
                 −1.0802737 
                 10.3524809 
                 −4.3710543 
                 5.08E−05 
                 0.00767831 
                 1.83047131 
               
               
                 224009_x_at 
                 DHRS9 
                 −1.0883843 
                 12.9995564 
                 −4.3451551 
                 5.56E−05 
                 0.00815484 
                 1.74834735 
               
               
                 219471_at 
                 C13ORF18 
                 −1.082994 
                 11.244718 
                 −4.3449394 
                 5.56E−05 
                 0.00815484 
                 1.74766447 
               
               
                 204674_at 
                 LRMP 
                 −1.0754387 
                 9.48836985 
                 −4.3365053 
                 5.73E−05 
                 0.00835029 
                 1.72097259 
               
               
                 225594_at 
                 ZF 
                 −1.0660997 
                 8.44053993 
                 −4.3348185 
                 5.76E−05 
                 0.00835466 
                 1.71563729 
               
               
                 64900_at 
                 CHST5 /// A           
                 −1.0783605 
                 7.45420385 
                 −4.3330734 
                 5.80E−05 
                 0.00836918 
                 1.71011893 
               
               
                 218326_s_at 
                 LGR4 
                 −1.1055698 
                 7.35402657 
                 −4.3327777 
                 5.80E−05 
                 0.00836918 
                 1.70918383 
               
               
                 204639_at 
                 ADA 
                 −1.0663173 
                 8.71406105 
                 −4.3311807 
                 5.83E−05 
                 0.00839318 
                 1.70413466 
               
               
                 220416_at 
                 ATP8B4 
                 −1.0560097 
                 10.8651277 
                 −4.3288715 
                 5.88E−05 
                 0.00843796 
                 1.69683558 
               
               
                 226255_at 
                 ZBTB33 
                 −1.056353 
                 11.34447 
                 −4.3186727 
                 6.09E−05 
                 0.00862606 
                 1.66462107 
               
               
                 204548_at 
                 STAR 
                 −1.0828983 
                 8.71225533 
                 −4.3131689 
                 6.21E−05 
                 0.00876809 
                 1.64725213 
               
               
                 207865_s_at 
                 BMP8B 
                 −1.1309201 
                 9.46800068 
                 −4.3117307 
                 6.24E−05 
                 0.00878882 
                 1.64271524 
               
               
                 244447_at 
                 KLF10 
                 −1.3134824 
                 7.8071422 
                 −4.2828862 
                 6.89E−05 
                 0.00950707 
                 1.55188213 
               
               
                 224837_at 
                 FOXP1 
                 −1.0552487 
                 11.2859527 
                 −4.279807 
                 6.96E−05 
                 0.00952643 
                 1.54220361 
               
               
                 201689_s_at 
                 TPD52 
                 −1.0726713 
                 9.3965084 
                 −4.2740096 
                 7.10E−05 
                 0.00967829 
                 1.52399041 
               
               
                 212097_at 
                 CAV1 
                 −1.0973744 
                 8.37508938 
                 −4.2610503 
                 7.42E−05 
                 0.00997486 
                 1.48332253 
               
               
                 1557570_a_a 
                 LOC285084 
                 −1.0977131 
                 8.27009497 
                 −4.2541445 
                 7.60E−05 
                 0.01008195 
                 1.46167694 
               
               
                 201690_s_at 
                 TPD52 
                 −1.073115 
                 10.5093023 
                 −4.2504384 
                 7.69E−05 
                 0.01016104 
                 1.45006755 
               
               
                 214920_at 
                 KIAA0960 
                 −1.1291766 
                 9.28547078 
                 −4.2405995 
                 7.96E−05 
                 0.01044325 
                 1.41927233 
               
               
                 226431_at 
                 ALS2CR13 
                 −1.0804181 
                 8.88019612 
                 −4.2395927 
                 7.98E−05 
                 0.01044325 
                 1.4161231 
               
               
                 227629_at 
                 PRLR 
                 −1.1385104 
                 7.04094281 
                 −4.2375147 
                 8.04E−05 
                 0.01046218 
                 1.40962463 
               
               
                 57540_at 
                 RBKS 
                 −1.0889358 
                 8.11543924 
                 −4.2362686 
                 8.08E−05 
                 0.01046218 
                 1.40572847 
               
               
                 228455_at 
                 SLC16A4 
                 −1.2438773 
                 7.61141506 
                 −4.2334573 
                 8.15E−05 
                 0.01049314 
                 1.39694035 
               
               
                 242511_at 
                 ST3GAL3 
                 −1.0989987 
                 7.9960706 
                 −4.2291028 
                 8.27E−05 
                 0.01057053 
                 1.38333428 
               
               
                 225619_at 
                 SLAIN1 
                 −1.1432234 
                 8.6802401 
                 −4.227198 
                 8.33E−05 
                 0.01058985 
                 1.37738486 
               
               
                 213737_x_at 
                 GOLGA8G //           
                 −1.0557244 
                 13.4113502 
                 −4.2214214 
                 8.49E−05 
                 0.01077515 
                 1.35935067 
               
               
                 224486_s_at 
                 C15ORF41 
                 −1.0809669 
                 9.42072522 
                 −4.2192321 
                 8.56E−05 
                 0.01083061 
                 1.35251877 
               
               
                 230480_at 
                 PIWIL4 
                 −1.0659842 
                 10.6705451 
                 −4.2178649 
                 8.60E−05 
                 0.01085599 
                 1.34825366 
               
               
                 225224_at 
                 C20ORF112 
                 −1.0767769 
                 9.19255558 
                 −4.1971114 
                 9.23E−05 
                 0.01151643 
                 1.28359413 
               
               
                 219799_s_at 
                 DHRS9 
                 −1.0873546 
                 12.5296658 
                 −4.1953591 
                 9.28E−05 
                 0.01155875 
                 1.27814225 
               
               
                 202979_s_at 
                 ZF 
                 −1.0920673 
                 9.89384482 
                 −4.1942804 
                 9.31E−05 
                 0.01157478 
                 1.27478664 
               
               
                 206461_x_at 
                 MT1H 
                 −1.0392307 
                 11.9250301 
                 −4.1935006 
                 9.34E−05 
                 0.01157914 
                 1.27236118 
               
               
                 201675_at 
                 AKAP1 
                 −1.0615779 
                 10.8983992 
                 −4.1859946 
                 9.58E−05 
                 0.01174461 
                 1.24902648 
               
               
                 227949_at 
                 PHACTR3 
                 −1.0599385 
                 10.7921228 
                 −4.1808322 
                 9.75E−05 
                 0.01184572 
                 1.2329899 
               
               
                 237265_at 
                 C16ORF73 
                 −1.0739194 
                 9.90657205 
                 −4.1786481 
                 9.82E−05 
                 0.0118711 
                 1.22620861 
               
               
                 235758_at 
                 PNMA6A 
                 −1.0679142 
                 8.36962585 
                 −4.1782399 
                 9.84E−05 
                 0.0118711 
                 1.22494122 
               
               
                 1554298_a_a 
                 WDR49 
                 −1.168549 
                 7.28424515 
                 −4.1686361 
                 0.00010161 
                 0.01212964 
                 1.19514511 
               
               
                 230008_at 
                 KIAA0960 
                 −1.1023476 
                 9.40901508 
                 −4.156767 
                 0.00010577 
                 0.01243643 
                 1.15837023 
               
               
                 215771_x_at 
                 RET 
                 −1.0639479 
                 8.73407172 
                 −4.1514318 
                 0.00010769 
                 0.01258151 
                 1.14185786 
               
               
                 204301_at 
                 KBTBD11 
                 −1.0665649 
                 10.3597689 
                 −4.1465423 
                 0.00010949 
                 0.01271022 
                 1.12673448 
               
               
                 201036_s_at 
                 HADH 
                 −1.0465759 
                 10.8776177 
                 −4.1465262 
                 0.00010949 
                 0.01271022 
                 1.12668456 
               
               
                 223044_at 
                 SLC40A1 
                 −1.0799265 
                 8.72509702 
                 −4.1435626 
                 0.00011059 
                 0.01281082 
                 1.11752261 
               
               
                 205996_s_at 
                 AK2 
                 −1.0533596 
                 11.6545132 
                 −4.1314862 
                 0.00011519 
                 0.01305473 
                 1.08022438 
               
               
                 213894_at 
                 KIAA0960 
                 −1.0975098 
                 9.74897241 
                 −4.1307312 
                 0.00011549 
                 0.01305473 
                 1.07789445 
               
               
                 235823_at 
                 LOC197322 
                 −1.0867032 
                 7.00344771 
                 −4.1303782 
                 0.00011562 
                 0.01305473 
                 1.07680534 
               
               
                 212593_s_at 
                 PDCD4 
                 −1.0784075 
                 9.6202895 
                 −4.1277406 
                 0.00011665 
                 0.01305473 
                 1.06866759 
               
               
                 227254_at 
                 — 
                 −1.0878832 
                 8.8387562 
                 −4.1270419 
                 0.00011693 
                 0.01305473 
                 1.06651244 
               
               
                 218082_s_at 
                 UBP1 
                 −1.061315 
                 11.2875622 
                 −4.1236056 
                 0.00011829 
                 0.01317223 
                 1.05591605 
               
               
                 221648_s_at 
                 C1ORF121 
                 −1.0625223 
                 9.30594001 
                 −4.1122294 
                 0.00012291 
                 0.01363084 
                 1.02086816 
               
               
                 225883_at 
                 ATG16L2 
                 −1.0866743 
                 8.95908959 
                 −4.1072117 
                 0.000125 
                 0.01380676 
                 1.0054261 
               
               
                 222388_s_at 
                 VPS35 
                 −1.0544103 
                 10.9995649 
                 −4.096001 
                 0.0001298 
                 0.01425665 
                 0.9709611 
               
               
                 208636_at 
                 ACTN1 
                 −1.0393569 
                 12.61059 
                 −4.0933116 
                 0.00013097 
                 0.01432201 
                 0.96270059 
               
               
                 204165_at 
                 WASF1 
                 −1.0621996 
                 10.2583762 
                 −4.0742957 
                 0.0001396 
                 0.01494692 
                 0.9043759 
               
               
                 239963_at 
                 — 
                 −1.2400451 
                 9.0375203 
                 −4.0742228 
                 0.00013963 
                 0.01494692 
                 0.9041527 
               
               
                 227055_at 
                 METTL7B 
                 −1.0860464 
                 10.9882916 
                 −4.0733051 
                 0.00014006 
                 0.01494692 
                 0.90134178 
               
               
                 229700_at 
                 LOC148203 
                 −1.0769984 
                 9.16397658 
                 −4.0732431 
                 0.00014009 
                 0.01494692 
                 0.90115181 
               
               
                 225720_at 
                 SYNPO2 
                 −1.093531 
                 8.22812673 
                 −4.0689427 
                 0.00014212 
                 0.01511757 
                 0.88798401 
               
               
                 233782_at 
                 WDR68 
                 −1.0892946 
                 7.81601785 
                 −4.0571162 
                 0.00014785 
                 0.01555469 
                 0.85180964 
               
               
                 226438_at 
                 MTBP 
                 −1.0674478 
                 9.28796451 
                 −4.0535202 
                 0.00014964 
                 0.01564376 
                 0.84082167 
               
               
                 200672_x_at 
                 SPTBN1 
                 −1.0717572 
                 7.97282842 
                 −4.0518568 
                 0.00015048 
                 0.01565768 
                 0.83574084 
               
               
                 228625_at 
                 CITED4 
                 −1.0665343 
                 12.4781742 
                 −4.0414018 
                 0.00015582 
                 0.01601409 
                 0.80383153 
               
               
                 223704_s_at 
                 DMRT2 
                 −1.0966738 
                 7.49852282 
                 −4.038741 
                 0.00015721 
                 0.01612655 
                 0.79571762 
               
               
                 223136_at 
                 AIG1 
                 −1.0602864 
                 11.4123181 
                 −4.0340714 
                 0.00015968 
                 0.01634893 
                 0.78148555 
               
               
                 218168_s_at 
                 CABC1 
                 −1.05636 
                 10.9814373 
                 −4.0298906 
                 0.00016192 
                 0.01654732 
                 0.76875062 
               
               
                 219056_at 
                 RNASEH2B 
                 −1.0587835 
                 9.59474393 
                 −4.0293131 
                 0.00016223 
                 0.01654826 
                 0.76699214 
               
               
                 1553955_at 
                 LOC129285 
                 −1.0626958 
                 9.65678818 
                 −4.0249191 
                 0.00016462 
                 0.01676095 
                 0.75361657 
               
               
                 216336_x_at 
                 MT1M 
                 −1.0417674 
                 11.497183 
                 −4.0083934 
                 0.00017392 
                 0.01757723 
                 0.70338342 
               
               
                 209007_s_at 
                 C1ORF63 
                 −1.0860359 
                 10.6932184 
                 −4.0033033 
                 0.00017689 
                 0.01782313 
                 0.68793375 
               
               
                 204959_at 
                 MNDA 
                 −1.0681514 
                 11.9635641 
                 −4.003101 
                 0.00017701 
                 0.01782313 
                 0.68732013 
               
               
                 232722_at 
                 RNASET2 
                 −1.121936 
                 6.4751986 
                 −3.9998645 
                 0.00017892 
                 0.0179496 
                 0.67750249 
               
               
                 201924_at 
                 AFF1 
                 −1.0636204 
                 10.9900787 
                 −3.9938919 
                 0.0001825 
                 0.01820614 
                 0.65939689 
               
               
                 205268_s_at 
                 ADD2 
                 −1.0749965 
                 8.29295849 
                 −3.9894046 
                 0.00018524 
                 0.01841452 
                 0.64580364 
               
               
                 217892_s_at 
                 LIMA1 
                 −1.0674835 
                 9.77391533 
                 −3.9742552 
                 0.00019477 
                 0.0190165 
                 0.59997453 
               
               
                 225610_at 
                 UHRF2 
                 −1.0478186 
                 11.8006338 
                 −3.9712363 
                 0.00019673 
                 0.01908993 
                 0.5908533 
               
               
                 213888_s_at 
                 TRAF3IP3 
                 −1.0732522 
                 10.3053256 
                 −3.9709396 
                 0.00019692 
                 0.01908993 
                 0.58995707 
               
               
                 209879_at 
                 SELPLG 
                 −1.0891682 
                 9.91966583 
                 −3.9695775 
                 0.00019781 
                 0.0191422 
                 0.58584343 
               
               
                 226630_at 
                 C14ORF106 
                 −1.0672553 
                 9.79100795 
                 −3.961139 
                 0.00020341 
                 0.01964899 
                 0.56037434 
               
               
                 225455_at 
                 TADA1L 
                 −1.0580187 
                 10.2337996 
                 −3.9517012 
                 0.00020985 
                 0.02016419 
                 0.5319252 
               
               
                 1554352_s_a 
                 DENND4A 
                 −1.0590459 
                 9.89217484 
                 −3.9498502 
                 0.00021113 
                 0.02022705 
                 0.52635021 
               
               
                 227805_at 
                 — 
                 −1.0725811 
                 7.97633184 
                 −3.9486352 
                 0.00021198 
                 0.02022705 
                 0.52269151 
               
               
                 204849_at 
                 TCFL5 
                 −1.0508793 
                 10.0777273 
                 −3.9473794 
                 0.00021286 
                 0.02027564 
                 0.51891058 
               
               
                 212174_at 
                 AK2 
                 −1.0435458 
                 12.5602536 
                 −3.9427886 
                 0.00021611 
                 0.02047123 
                 0.50509441 
               
               
                 243431_at 
                 BTBD14A 
                 −1.1988342 
                 7.54359435 
                 −3.9340968 
                 0.00022239 
                 0.02085605 
                 0.4789607 
               
               
                 1558027_s_a 
                 PRKAB2 
                 −1.0672869 
                 8.44162128 
                 −3.9261915 
                 0.00022825 
                 0.02129633 
                 0.45522005 
               
               
                 220615_s_at 
                 MLSTD1 
                 −1.0704751 
                 11.0839465 
                 −3.9246829 
                 0.00022939 
                 0.0213295 
                 0.45069271 
               
               
                 220116_at 
                 KCNN2 
                 −1.0475679 
                 10.7237831 
                 −3.9161743 
                 0.00023589 
                 0.02174968 
                 0.42517604 
               
               
                 201193_at 
                 IDH1 
                 −1.0387181 
                 11.9734806 
                 −3.9122575 
                 0.00023895 
                 0.02199427 
                 0.41344031 
               
               
                 225782_at 
                 MSRB3 
                 −1.0704 
                 8.85357731 
                 −3.9114057 
                 0.00023962 
                 0.02201882 
                 0.41088889 
               
               
                 218270_at 
                 MRPL24 
                 −1.041775 
                 10.7168033 
                 −3.9080124 
                 0.0002423 
                 0.02219357 
                 0.40072844 
               
               
                 1559139_at 
                 NOC2L 
                 −1.1614047 
                 7.69426499 
                 −3.9079762 
                 0.00024233 
                 0.02219357 
                 0.4006202 
               
               
                 201841_s_at 
                 HSPB1 
                 −1.0441743 
                 13.4381243 
                 −3.9073471 
                 0.00024283 
                 0.02220226 
                 0.39873692 
               
               
                 1569189_at 
                 TTC9C 
                 −1.1233947 
                 6.22264013 
                 −3.9060463 
                 0.00024387 
                 0.02226003 
                 0.39484371 
               
               
                 205944_s_at 
                 CLTCL1 
                 −1.0767087 
                 9.59502778 
                 −3.8960537 
                 0.000252 
                 0.0227332 
                 0.36496078 
               
               
                 218532_s_at 
                 FLJ20152 
                 −1.0975951 
                 7.14515674 
                 −3.8958965 
                 0.00025213 
                 0.0227332 
                 0.36449103 
               
               
                 205659_at 
                 HDAC9 
                 −1.0805755 
                 9.52806368 
                 −3.8955883 
                 0.00025238 
                 0.0227332 
                 0.36356988 
               
               
                 228056_s_at 
                 NAPSB 
                 −1.133171 
                 8.05318337 
                 −3.8864469 
                 0.00025006 
                 0.02323287 
                 0.33627243 
               
               
                 208158_s_at 
                 OSBPL1A 
                 −1.0689057 
                 8.96913414 
                 −3.8834664 
                 0.0002626 
                 0.0233462 
                 0.32738037 
               
               
                 241024_at 
                 C6ORF147 
                 −1.130088 
                 5.62544192 
                 −3.8775071 
                 0.00026777 
                 0.02367801 
                 0.30961257 
               
               
                 212859_x_at 
                 MT1E 
                 −1.0360762 
                 12.3752245 
                 −3.8735521 
                 0.00027126 
                 0.02392114 
                 0.29782945 
               
               
                 219498_s_at 
                 BCL11A 
                 −1.0732492 
                 8.13793041 
                 −3.8714456 
                 0.00027313 
                 0.0240476 
                 0.29155627 
               
               
                 215095_at 
                 ESD 
                 −1.1487406 
                 5.82227073 
                 −3.8696858 
                 0.00027471 
                 0.02414738 
                 0.28631705 
               
               
                 203253_s_at 
                 HISPPD1 
                 −1.0681144 
                 10.4329202 
                 −3.8669778 
                 0.00027715 
                 0.02432282 
                 0.2782577 
               
               
                 213416_at 
                 ITGA4 
                 −1.0669742 
                 10.3810332 
                 −3.8619771 
                 0.00028171 
                 0.02456545 
                 0.26338338 
               
               
                 1557283_a_a 
                 ZNF519 
                 −1.1068414 
                 5.33423642 
                 −3.8586267 
                 0.00028481 
                 0.02479593 
                 0.25342411 
               
               
                 230424_at 
                 C5ORF13 
                 −1.129586 
                 6.85369311 
                 −3.8555889 
                 0.00028764 
                 0.02492377 
                 0.24439825 
               
               
                 230550_at 
                 MS4A6A 
                 −1.0527231 
                 11.5245536 
                 −3.8469498 
                 0.00029586 
                 0.02543398 
                 0.21875242 
               
               
                 1555963_x_a 
                 B3GNT7 
                 −1.0971417 
                 7.71455009 
                 −3.8417726 
                 0.00030089 
                 0.02570473 
                 0.20339936 
               
               
                 203518_at 
                 LYST 
                 −1.0508267 
                 12.5285349 
                 −3.8410237 
                 0.00030162 
                 0.02572727 
                 0.20117947 
               
               
                 229084_at 
                 CNTN4 
                 −1.1046924 
                 8.60627464 
                 −3.8396872 
                 0.00030294 
                 0.02579917 
                 0.19721855 
               
               
                 200912_s_at 
                 EIF4A2 
                 −1.0342758 
                 13.3848401 
                 −3.8372855 
                 0.00030531 
                 0.02584057 
                 0.19010257 
               
               
                 243514_at 
                 — 
                 −1.1677325 
                 8.64926127 
                 −3.834963 
                 0.00030763 
                 0.02599628 
                 0.18322394 
               
               
                 1560495_at 
                 — 
                 −1.0868663 
                 7.91686834 
                 −3.8289949 
                 0.00031366 
                 0.02626207 
                 0.16555845 
               
               
                 209539_at 
                 ARHGEF6 
                 −1.0428012 
                 11.4186716 
                 −3.8184713 
                 0.00032456 
                 0.02696861 
                 0.13444828 
               
               
                 211980_at 
                 COL4A1 
                 −1.0583579 
                 8.52391992 
                 −3.8156429 
                 0.00032755 
                 0.02717595 
                 0.1260953 
               
               
                 222538_s_at 
                 APPL 
                 −1.0538895 
                 9.69059359 
                 −3.8135376 
                 0.0003298 
                 0.02730892 
                 0.11988026 
               
               
                 217540_at 
                 — 
                 −1.0829555 
                 9.09428634 
                 −3.8128923 
                 0.00033049 
                 0.02730892 
                 0.11797567 
               
               
                 231950_at 
                 ZNF658 
                 −1.0895471 
                 8.18062639 
                 −3.8089596 
                 0.00033473 
                 0.02756221 
                 0.10637231 
               
               
                 221900_at 
                 COL8A2 
                 −1.0731684 
                 10.4949814 
                 −3.8010969 
                 0.00034336 
                 0.02814612 
                 0.0831949 
               
               
                 229033_s_at 
                 MUM1 
                 −1.0955974 
                 7.47621492 
                 −3.798449 
                 0.00034632 
                 0.02830357 
                 0.0753956 
               
               
                 201688_s_at 
                 TPD52 
                 −1.0610401 
                 9.71085633 
                 −3.7945851 
                 0.00035068 
                 0.02857425 
                 0.0640208 
               
               
                 209960_at 
                 HGF 
                 −1.1259855 
                 5.57784014 
                 −3.7926895 
                 0.00035283 
                 0.02870722 
                 0.05844274 
               
               
                 232232_s_at 
                 SLC22A16 
                 −1.0425388 
                 11.5170133 
                 −3.785579 
                 0.00036104 
                 0.02915779 
                 0.03753396 
               
               
                 223470_at 
                 PIGM 
                 −1.0448041 
                 10.782124 
                 −3.7837211 
                 0.00036321 
                 0.02924694 
                 0.03207456 
               
               
                 218540_at 
                 THTPA 
                 −1.0678164 
                 9.37118811 
                 −3.782058 
                 0.00036517 
                 0.02936123 
                 0.0271889 
               
               
                 226773_at 
                 — 
                 −1.0599901 
                 8.73474937 
                 −3.7794255 
                 0.00036829 
                 0.02956841 
                 0.0194579 
               
               
                 238098_at 
                 — 
                 −1.1114847 
                 5.09426112 
                 −3.778084 
                 0.00036989 
                 0.02961164 
                 0.01551954 
               
               
                 217707_x_at 
                 SMARCA2 
                 −1.0808866 
                 10.5195127 
                 −3.7780645 
                 0.00036991 
                 0.02961164 
                 0.01546237 
               
               
                 212993_at 
                 — 
                 −1.0777658 
                 10.0764962 
                 −3.7708097 
                 0.00037867 
                 0.03004896 
                 −0.0058219 
               
               
                 229123_at 
                 — 
                 −1.0812886 
                 7.27161787 
                 −3.7693556 
                 0.00038045 
                 0.03009487 
                 −0.010085 
               
               
                 235036_at 
                 LIX1L 
                 −1.0722631 
                 8.44284176 
                 −3.7689888 
                 0.0003809 
                 0.03009487 
                 −0.0111601 
               
               
                 1557261_at 
                 WHDC1L1 //           
                 −1.1135936 
                 8.0995202 
                 −3.7678412 
                 0.00038231 
                 0.03011937 
                 −0.0145238 
               
               
                 228904_at 
                 HOXB3 
                 −1.0881045 
                 7.40156866 
                 −3.7669423 
                 0.00038342 
                 0.03016331 
                 −0.0171583 
               
               
                 201381_x_at 
                 CACYBP 
                 −1.0345348 
                 12.6646023 
                 −3.7613887 
                 0.00039034 
                 0.03049295 
                 −0.0334251 
               
               
                 224800_at 
                 WDFY1 
                 −1.0460265 
                 11.2146548 
                 −3.7556441 
                 0.00039763 
                 0.03085591 
                 −0.0502365 
               
               
                 228497_at 
                 SLC22A15 
                 −1.0528433 
                 10.2806063 
                 −3.7504565 
                 0.00040432 
                 0.03126767 
                 −0.0654047 
               
               
                 218376_s_at 
                 MICAL1 
                 −1.063991 
                 10.8151846 
                 −3.7464229 
                 0.0004096 
                 0.0314976 
                 −0.0771901 
               
               
                 214997_at 
                 GOLGA1 
                 −1.1629895 
                 5.40289373 
                 −3.7438471 
                 0.000413 
                 0.03166964 
                 −0.084712 
               
               
                 232168_x_at 
                 MACF1 
                 −1.1118803 
                 7.19380131 
                 −3.7436429 
                 0.00041327 
                 0.03166964 
                 −0.0853084 
               
               
                 215143_at 
                 FLJ36166 
                 −1.1403943 
                 5.25780477 
                 −3.7428445 
                 0.00041434 
                 0.03166964 
                 −0.0876391 
               
               
                 229712_at 
                 SNAPC3 
                 −1.1504135 
                 5.48415471 
                 −3.7427571 
                 0.00041445 
                 0.03166964 
                 −0.0878942 
               
               
                 208910_s_at 
                 C1QBP 
                 −1.0363862 
                 12.212373 
                 −3.7403131 
                 0.00041772 
                 0.03172049 
                 −0.0950274 
               
               
                 223343_at 
                 MS4A7 
                 −1.0576569 
                 11.3702217 
                 −3.7294854 
                 0.00043249 
                 0.03261559 
                 −0.1265955 
               
               
                 216007_at 
                 CLSTN2 
                 −1.1573199 
                 5.8326347 
                 −3.7201011 
                 0.00044569 
                 0.03342695 
                 −0.153911 
               
               
                 218477_at 
                 TMEM14A 
                 −1.0520488 
                 11.0359972 
                 −3.7120317 
                 0.00045735 
                 0.03401174 
                 −0.1773659 
               
               
                 225716_at 
                 — 
                 −1.0488569 
                 12.276306 
                 −3.711697 
                 0.00045784 
                 0.03401174 
                 −0.1783381 
               
               
                 229934_at 
                 — 
                 −1.1078549 
                 9.5045234 
                 −3.7090958 
                 0.00046167 
                 0.03418201 
                 −0.1858919 
               
               
                 226020_s_at 
                 DAB1 /// O           
                 −1.0604674 
                 9.19536151 
                 −3.7080794 
                 0.00046317 
                 0.03418201 
                 −0.1888427 
               
               
                 231300_at 
                 LOC90835 
                 −1.0706749 
                 8.05881715 
                 −3.7080185 
                 0.00046326 
                 0.03418201 
                 −0.1890194 
               
               
                 225431_x_at 
                 ACY1L2 
                 −1.1051561 
                 9.95149452 
                 −3.6951992 
                 0.00048263 
                 0.03517085 
                 −0.2261934 
               
               
                 239503_at 
                 — 
                 −1.1019241 
                 6.4612666 
                 −3.6931957 
                 0.00048572 
                 0.03517085 
                 −0.2319963 
               
               
                 208747_s_at 
                 C1S 
                 −1.0897058 
                 7.74085712 
                 −3.6813511 
                 0.00050442 
                 0.03616953 
                 −0.2662632 
               
               
                 210658_s_at 
                 GGA2 
                 −1.0464213 
                 10.9126279 
                 −3.6763333 
                 0.00051254 
                 0.03648841 
                 −0.2807596 
               
               
                 207405_s_at 
                 RAD17 
                 −1.0614693 
                 9.75893285 
                 −3.6739986 
                 0.00051636 
                 0.03662349 
                 −0.2875005 
               
               
                 218792_s_at 
                 BSPRY 
                 −1.0964707 
                 7.1685673 
                 −3.6700784 
                 0.00052284 
                 0.037029 
                 −0.2988132 
               
               
                 224838_at 
                 FOXP1 
                 −1.0451305 
                 11.003461 
                 −3.666886 
                 0.00052818 
                 0.03716608 
                 −0.3080204 
               
               
                 208956_x_at 
                 DUT 
                 −1.0305575 
                 13.3123909 
                 −3.6657787 
                 0.00053004 
                 0.03717544 
                 −0.3112129 
               
               
                 210375_at 
                 PTGER3 
                 −1.122068 
                 4.90394615 
                 −3.6657484 
                 0.00053009 
                 0.03717544 
                 −0.3113002 
               
               
                 233252_s_at 
                 STRBP 
                 −1.0460631 
                 9.42442497 
                 −3.6597179 
                 0.00054034 
                 0.03777915 
                 −0.3286758 
               
               
                 202309_at 
                 MTHFD1 
                 −1.0363875 
                 11.5356701 
                 −3.6479618 
                 0.00056088 
                 0.03888847 
                 −0.3624982 
               
               
                 212510_at 
                 GPD1L 
                 −1.0564567 
                 9.5177254 
                 −3.6426294 
                 0.00057044 
                 0.03942724 
                 −0.3778178 
               
               
                 232242_at 
                 C3ORF14 
                 −1.1397197 
                 5.05025398 
                 −3.6421706 
                 0.00057127 
                 0.03942724 
                 −0.3791352 
               
               
                 203335_at 
                 PHYH 
                 −1.0509077 
                 9.47404929 
                 −3.6414392 
                 0.00057259 
                 0.03942897 
                 −0.3812352 
               
               
                 225876_at 
                 NPAL3 
                 −1.0545782 
                 8.47639608 
                 −3.6399342 
                 0.00057533 
                 0.03956752 
                 −0.3855556 
               
               
                 226038_at 
                 LONRF1 
                 −1.0686626 
                 8.27265094 
                 −3.6331772 
                 0.00058777 
                 0.04027091 
                 −0.4049391 
               
               
                 241466_at 
                 MTL5 
                 −1.0881094 
                 7.2321193 
                 −3.630577 
                 0.00059262 
                 0.04050197 
                 −0.4123921 
               
               
                 232702_at 
                 RABGAP1L 
                 −1.1084819 
                 7.2641058 
                 −3.629559 
                 0.00059453 
                 0.04053125 
                 −0.4153094 
               
               
                 228157_at 
                 ZNF207 
                 −1.1331898 
                 9.20083267 
                 −3.628722 
                 0.00059611 
                 0.04058804 
                 −0.4177074 
               
               
                 220892_s_at 
                 PSAT1 
                 −1.0539762 
                 10.5575882 
                 −3.6260997 
                 0.00060107 
                 0.04087498 
                 −0.4252181 
               
               
                 211987_at 
                 TOP2B 
                 −1.0376579 
                 11.6916878 
                 −3.6237021 
                 0.00060564 
                 0.04108363 
                 −0.4320824 
               
               
                 207636_at 
                 SERPINI2 
                 −1.1147369 
                 8.32640727 
                 −3.6221365 
                 0.00060864 
                 0.04123615 
                 −0.4365631 
               
               
                 1555702_a_a 
                 ST3GAL3 
                 −1.0571721 
                 11.469985 
                 −3.6202073 
                 0.00061236 
                 0.04138559 
                 −0.4420828 
               
               
                 208967_s_at 
                 AK2 
                 −1.0444004 
                 11.8885466 
                 −3.6083697 
                 0.00063567 
                 0.04259196 
                 −0.4759123 
               
               
                 227233_at 
                 TSPAN2 
                 −1.0933291 
                 4.88565746 
                 −3.6039803 
                 0.00064452 
                 0.04297454 
                 −0.488439 
               
               
                 1561488_at 
                 — 
                 −1.0791431 
                 8.42185259 
                 −3.5998639 
                 0.00065293 
                 0.04336219 
                 −0.5001777 
               
               
                 232034_at 
                 LOC203274 
                 −1.1061415 
                 8.7194472 
                 −3.59871 
                 0.00065531 
                 0.04342891 
                 −0.5034667 
               
               
                 210817_s_at 
                 CALCOCO2 
                 −1.0381701 
                 11.2547695 
                 −3.5973152 
                 0.00065819 
                 0.04351451 
                 −0.5074419 
               
               
                 208990_s_at 
                 HNRPH3 
                 −1.0433996 
                 11.010468 
                 −3.5949274 
                 0.00066315 
                 0.04378974 
                 −0.5142443 
               
               
                 205550_s_at 
                 BRE 
                 −1.042758 
                 10.1098377 
                 −3.5935936 
                 0.00066594 
                 0.0438679 
                 −0.518043 
               
               
                 218461_at 
                 ATPBD1C 
                 −1.044665 
                 10.8560567 
                 −3.588935 
                 0.00067577 
                 0.04421781 
                 −0.5313034 
               
               
                 203774_at 
                 MTR 
                 −1.0520755 
                 1.5810662 
                 −3.5887762 
                 0.00067611 
                 0.04421781 
                 −0.5317553 
               
               
                 1554791_a_a 
                 FLJ23861 
                 −1.0802814 
                 7.25343472 
                 −3.5862528 
                 0.00068149 
                 0.0444105 
                 −0.5389334 
               
               
                 227662_at 
                 SYNPO2 
                 −1.0748437 
                 9.18363146 
                 −3.5850906 
                 0.00068398 
                 0.04451989 
                 −0.5422384 
               
               
                 235374_at 
                 MDH1 
                 −1.1308822 
                 8.18431482 
                 −3.584254 
                 0.00068578 
                 0.04454185 
                 −0.5446169 
               
               
                 211929_at 
                 HNRPA3 
                 −1.0599635 
                 11.1782682 
                 −3.5831072 
                 0.00068826 
                 0.04454185 
                 −0.5478769 
               
               
                 236421_at 
                 ANKRD45 
                 −1.1046422 
                 7.81492792 
                 −3.5820889 
                 0.00069046 
                 0.04454185 
                 −0.5507713 
               
               
                 222428_s_at 
                 LARS 
                 −1.044671 
                 11.3066627 
                 −3.5819545 
                 0.00069075 
                 0.04454185 
                 −0.551153 
               
               
                 218404_at 
                 SNX10 
                 −1.0542239 
                 10.5371703 
                 −3.5819241 
                 0.00069082 
                 0.04454185 
                 −0.5512396 
               
               
                 225845_at 
                 ZBTB44 
                 −1.0510504 
                 10.114137 
                 −3.5792352 
                 0.00069667 
                 0.0448057 
                 −0.5588792 
               
               
                 228030_at 
                 — 
                 −1.1453293 
                 8.222179 
                 −3.5744486 
                 0.00070722 
                 0.04522467 
                 −0.5724699 
               
               
                 205543_at 
                 HSPA4L 
                 −1.0619155 
                 10.0871911 
                 −3.5711304 
                 0.00071461 
                 0.04550224 
                 −0.5818846 
               
               
                 222786_at 
                 CHST12 
                 −1.0953465 
                 8.08550285 
                 −3.5710089 
                 0.00071489 
                 0.04550224 
                 −0.5822293 
               
               
                 226148_at 
                 ZBTB44 
                 −1.044973 
                 10.9431965 
                 −3.5699976 
                 0.00071716 
                 0.04559364 
                 −0.5850975 
               
               
                 220007_at 
                 METTL8 
                 −1.0742738 
                 7.97164029 
                 −3.568486 
                 0.00072056 
                 0.04570388 
                 −0.5893838 
               
               
                 232049_at 
                 — 
                 −1.1055172 
                 3.71843028 
                 −3.5666355 
                 0.00072475 
                 0.04531638 
                 −0.5946293 
               
               
                 225639_at 
                 SKAP2 
                 −1.0513915 
                 10.9430745 
                 −3.5623166 
                 0.00073462 
                 0.04643409 
                 −0.6068655 
               
               
                 201432_at 
                 CAT 
                 −1.029344 
                 13.2389426 
                 −3.5605892 
                 0.00073861 
                 0.04663198 
                 −0.611757 
               
               
                 243366_s_at 
                 CERKL 
                 −1.0677271 
                 9.52062508 
                 −3.5590761 
                 0.00074211 
                 0.04665922 
                 −0.6160402 
               
               
                 239163_at 
                 UBE2B 
                 −1.115315 
                 5.28263677 
                 −3.5589302 
                 0.00074245 
                 0.04665922 
                 −0.6164534 
               
               
                 239911_at 
                 — 
                 −1.1157309 
                 6.92640942 
                 −3.5564148 
                 0.00074832 
                 0.04692001 
                 −0.6235711 
               
               
                 239841_at 
                 C7ORF24 
                 −1.1067027 
                 8.40618863 
                 −3.5537484 
                 0.00075458 
                 0.04706777 
                 −0.6311131 
               
               
                 213510_x_at 
                 LOC220594 
                 −1.0787105 
                 9.26871882 
                 −3.5532589 
                 0.00075574 
                 0.04706777 
                 −0.6324971 
               
               
                 203446_s_at 
                 OCRL 
                 −1.0590145 
                 8.52928391 
                 −3.5522168 
                 0.00075821 
                 0.04716146 
                 −0.6354436 
               
               
                 220900_at 
                 FLJ12078 
                 −1.2242895 
                 4.04470354 
                 −3.550766 
                 0.00076165 
                 0.04732199 
                 −0.6395446 
               
               
                 222427_s_at 
                 LARS 
                 −1.0327116 
                 11.8350021 
                 −3.5464813 
                 0.00077192 
                 0.04764859 
                 −0.6516498 
               
               
                 213908_at 
                 WHDC1L1 //           
                 −1.106503 
                 7.49688229 
                 −3.54639 
                 0.00077214 
                 0.04764859 
                 −0.6519076 
               
               
                 235170_at 
                 ZNF92 
                 −1.0701713 
                 10.4753161 
                 −3.5440334 
                 0.00077784 
                 0.04781967 
                 −0.6585616 
               
               
                 205804_s_at 
                 TRAF3IP3 
                 −1.0645947 
                 10.430865 
                 −3.5397143 
                 0.0007884 
                 0.04837904 
                 −0.6707492 
               
               
                 227865_at 
                 C9ORF103 
                 −1.0549476 
                 9.09854389 
                 −3.537566 
                 0.0007937 
                 0.04864948 
                 −0.6768078 
               
               
                 201769_at 
                 CLINT1 
                 −1.0404695 
                 11.3472898 
                 −3.5358759 
                 0.0007979 
                 0.04872219 
                 −0.6815728 
               
               
                 1555962_at 
                 B3GNT7 
                 −1.0816315 
                 8.07026497 
                 −3.5328566 
                 0.00080544 
                 0.04891403 
                 −0.6900812 
               
               
                 244050_at 
                 PTPLAD2 
                 −1.0466927 
                 10.2444943 
                 −3.5293148 
                 0.00081438 
                 0.04930933 
                 −0.7000563 
               
               
                 1554704_at 
                 ATP8B3 
                 −1.0775601 
                 9.03671576 
                 −3.5253989 
                 0.00082438 
                 0.04963954 
                 −0.7110776 
               
               
                   
               
               
                             indicates data missing or illegible when filed 
               
             
          
         
       
     
       Polimunol and Copaxone Comparison: Differentially Expressed Pathways 
       [0427]    In order to identify pathways differentially expressed by Polimunol compared with Copaxone, the input probesets had to comply not only with the conservative steps described above (resulting in a set of 779 differentially expressed probesets), but also with a fold change threshold of |FC|≧1.1. Pathway enrichment analysis employed the NIH DAVID platform, resulting in 137 pathways enriched among top probesets upregulated by Polimunol relative to Copaxone®. Pathways significantly enriched among top probesets differentially expressed between Polimunol and Copaxone in THP-1 cells are listed in Table 29. 
         [0000]    
       
         
               
             
               
               
               
               
               
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 29 
               
             
             
               
                   
               
               
                 Pathways significantly enriched among top probesets 
               
               
                 differentially expressed between Polimunol and Copaxone ® in THP-1 cells. 
               
             
          
           
               
                   
                   
                   
                   
                 Fold 
                   
               
               
                 Category 
                 Term 
                 Count 
                 Pvalue 
                 Enrichment 
                 Benjamini 
               
               
                   
               
             
          
           
               
                 GOTERM_BP_ALL 
                 GO: G009605~response to external stimulus 
                 34 
                 125E−12 
                 4.242127482 
                 2.13E−09 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050896~response to stimulus 
                 66 
                 1.47E−11 
                 2.221777115 
                 1.25E−08 
               
               
                 GOTERM_BP_ALL 
                 GO: 0009611~response to wounding 
                 24 
                 1.10E−10 
                 5.226859162 
                 6.26E−08 
               
               
                 GOTERM_BP_ALL 
                 GO: 0051239~regulation of multicellular organismal 
                 30 
                 2.86E−09 
                 3.546434111 
                 1.22E−06 
               
               
                   
                 process 
                   
                   
                   
                   
               
               
                 GOTERM_BP_ALL 
                 GO: 0006950~response to stress 
                 45 
                 3.97E−09 
                 2.52009281 
                 1.35E−06 
               
               
                 GOTERM_CC_ALL 
                 GO: 0005576~extracellular region 
                 32 
                 1.62E−08 
                 3.124422358 
                 2.46E−06 
               
               
                 GOTERM_BP_ALL 
                 GO: 0002376~immune system process 
                 31 
                 9.83E−09 
                 3.264522306 
                 2.79E−06 
               
               
                 GOTERM_MF_ALL 
                 GO: 0004888~transmembrane receptor activity 
                 21 
                 7.19E−08 
                 4.277319182 
                 9.08E−06 
               
               
                 GOTERM_MF_ALL 
                 GO: 0004872~receptor activity 
                 30 
                 6.09E−08 
                 3.099082935 
                 1.15E−05 
               
               
                 GOTERM_BP_ALL 
                 GO: 0006955~immune response 
                 23 
                 6.20E−08 
                 3.925650193 
                 1.51E−05 
               
               
                 KEGG_PATHWAY 
                 hsa04060: Cytokine-cytokine receptor interaction 
                 14 
                 2.08E−07 
                 6.068719076 
                 1.92E−05 
               
               
                 GOTERM_MF_ALL 
                 GO: 0004871~signal transducer activity 
                 37 
                 5.51E−08 
                 2.648089319 
                 2.09E−05 
               
               
                 GOTERM_MF_ALL 
                 GO: 0060089~molecular transducer activity 
                 37 
                 5.51E−08 
                 2.648089319 
                 2.09E−05 
               
               
                 GOTERM_BP_ALL 
                 GO: 0006952~defense response 
                 21 
                 1.12E−07 
                 4.15637457 
                 2.37E−05 
               
               
                 GOTERM_BP_ALL 
                 GO: 0032879~regulation of localization 
                 22 
                 1.58E−07 
                 3.885957066 
                 2.98E−05 
               
               
                 GOTERM_MF_ALL 
                 GO: 0030247~polysaccharide binding 
                 10 
                 4.26E−07 
                 10.28108466 
                 4.04E−05 
               
               
                 GOTERM_MF_ALL 
                 GO: 0001871~pattern binding 
                 10 
                 4.26E−07 
                 10.28108466 
                 4.04E−05 
               
               
                 GOTERM_CC_ALL 
                 GO: 0005615~extracellular space 
                 17 
                 6.80E−07 
                 4.626388691 
                 5.17E−05 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048583~regulation of response to stimulus 
                 19 
                 3.08E−07 
                 4.32390456 
                 5.23E−05 
               
               
                 GOTERM_CC_ALL 
                 GO: 0044421~extracellular region part 
                 19 
                 2.56E−06 
                 3.750331428 
                 9.73E−05 
               
               
                 GOTERM_CC_ALL 
                 GO: 0005886~plasma membrane 
                 51 
                 1.99E−06 
                 1.918590604 
                 0.00010059 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050794~regulation of cellular process 
                 97 
                 7.60E−07 
                 1.431262036 
                 0.00010778 
               
               
                 GOTERM_BP_ALL 
                 GO: 0042127~regulation of cell proliferation 
                 25 
                 8.88E−07 
                 3.138545339 
                 0.00010788 
               
               
                 GOTERM_BP_ALL 
                 GO: 0007166~cell surface receptor linked signal 
                 30 
                 8.25E−07 
                 2.737037737 
                 0.000108 
               
               
                   
                 transduction 
                   
                   
                   
                   
               
               
                 GOTERM_BP_ALL 
                 GO: 0006954~inflammatory response 
                 15 
                 7.41E−07 
                 5.299032363 
                 0.0001146 
               
               
                 GOTERM_BP_ALL 
                 GO: 0042221~response to chemical stimulus 
                 33 
                 1.27E−06 
                 2.509579282 
                 0.00013487 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050789~regulation of biological process 
                 99 
                 1.24E−06 
                 1.405133361 
                 0.00014066 
               
               
                 GOTERM_BP_ALL 
                 GO: 0065007~biological regulation 
                 101 
                 2.61E−06 
                 1.374157191 
                 0.00023327 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048584~positive regulation of response to stimulus 
                 13 
                 2.38E−06 
                 5.72397892 
                 0.00023849 
               
               
                 GOTERM_BP_ALL 
                 GO: 0002684~positive regulation of immune system 
                 13 
                 2.57E−06 
                 5.682799215 
                 0.00024311 
               
               
                   
                 process 
                   
                   
                   
                   
               
               
                 GOTERM_BP_ALL 
                 GO: 0001568~blood vessel development 
                 13 
                 4.31E−06 
                 5.410336239 
                 0.00036654 
               
               
                 GOTERM_BP_ALL 
                 GO: 0001944~vasculature development 
                 13 
                 4.97E−06 
                 5.337223587 
                 0.00038399 
               
               
                 GOTERM_BP_ALL 
                 GO: 0042060~wound healing 
                 11 
                 4.89E−06 
                 6.683846154 
                 0.00039593 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048519~negative regulation of biological process 
                 41 
                 6.21E−06 
                 2.055488241 
                 0.00040825 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048514~blood vessel morphogenesis 
                 12 
                 6.15E−06 
                 5.786879787 
                 0.00041817 
               
               
                 GOTERM_BP_ALL 
                 GO: 0002682~regulation of immune system process 
                 16 
                 5.94E−06 
                 4.154682924 
                 0.00042096 
               
               
                 GOTERM_BP_ALL 
                 GO: 0007165~signal transduction 
                 45 
                 5.71E−06 
                 1.96288636 
                 0.00042219 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050793~regulation of developmental process 
                 21 
                 7.97E−06 
                 3.166270454 
                 0.0004676 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048731~system development 
                 41 
                 7.80E−06 
                 2.037000612 
                 0.00047369 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050776~regulation of immune response 
                 12 
                 7.72E−06 
                 5.652301187 
                 0.00048624 
               
               
                 GOTERM_BP_ALL 
                 GO: 0051240~positive regulation of multicellular 
                 12 
                 1.19E−05 
                 5.401087801 
                 0.0006771 
               
               
                   
                 organismal process 
                   
                   
                   
                   
               
               
                 GOTERM_BP_ALL 
                 GO: 0060341~regulation of cellular localization 
                 11 
                 2.31E−05 
                 5.61667744 
                 0.00126569 
               
               
                 GOTERM_BP_ALL 
                 GO: 0032501~multicellular organismal process 
                 55 
                 2.47E−05 
                 1.69297015 
                 0.00131208 
               
               
                 GOTERM_BP_ALL 
                 GO: 0002703~regulation of leukocyte mediated immunity 
                 7 
                 3.08E−05 
                 11.1930438 
                 0.00158406 
               
               
                 GOTERM_MF_ALL 
                 GO: 0005539~glycosaminoglycan binding 
                 8 
                 2.69E−05 
                 8.933908046 
                 0.0020367 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048646~anatomical structure formation involved in 
                 14 
                 5.46E−05 
                 3.902162058 
                 0.00272943 
               
               
                   
                 morphogenesis 
                   
                   
                   
                   
               
               
                 GOTERM_BP_ALL 
                 GO: 0043066~negative regulation of apoptosis 
                 15 
                 8.17E−05 
                 3.519048519 
                 0.00396163 
               
               
                 GOTERM_MF_ALL 
                 GO: 0001608~nucleotide receptor activity, G-protein 
                 5 
                 6.34E−05 
                 21.59027778 
                 0.00399802 
               
               
                   
                 coupled 
                   
                   
                   
                   
               
               
                 GOTERM_MF_ALL 
                 GO: 0045028~purinergic nucleotide receptor activity, G- 
                 5 
                 6.34E−05 
                 21.59027778 
                 0.00399802 
               
               
                   
                 protein coupled 
                   
                   
                   
                   
               
               
                 GOTERM_BP_ALL 
                 GO: 0043069~negative regulation of programmed cell 
                 15 
                 9.24E−05 
                 3.47875407 
                 0.00423954 
               
               
                   
                 death 
                   
                   
                   
                   
               
               
                 KEGG_PATHWAY 
                 hsa04610: Complement and coagulation cascades 
                 6 
                 9.31E−05 
                 12.09974425 
                 0.00427423 
               
               
                 GOTERM_BP_ALL 
                 GO: 0060548~negative regulation of cell death 
                 15 
                 9.63E−05 
                 3.465526869 
                 0.00429948 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048856~anatomical structure development 
                 41 
                 9.18E−05 
                 1.834500551 
                 0.00433037 
               
               
                 GOTERM_BP_ALL 
                 GO: 0001525~angiogenesis 
                 9 
                 0.00010467 
                 6.076223776 
                 0.00444135 
               
               
                 GOTERM_BP_ALL 
                 GO: 0001819~positive regulation of cytokine production 
                 8 
                 0.00010299 
                 7.255192569 
                 0.00448212 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048660~regulation of smooth muscle cell 
                 6 
                 0.00011139 
                 12.15244755 
                 0.00461078 
               
               
                   
                 proliferation 
                   
                   
                   
                   
               
               
                 GOTERM_BP_ALL 
                 GO: 0048518~positive regulation of biological process 
                 40 
                 0.00011815 
                 1.834331706 
                 0.00477377 
               
               
                 GOTERM_BP_ALL 
                 GO: 0032502~developmental process 
                 48 
                 0.00013028 
                 1.687839938 
                 0.00514072 
               
               
                 GOTERM_BP_ALL 
                 GO: 0007275~multicellular organismal development 
                 44 
                 0.00014296 
                 1.743991169 
                 0.00551191 
               
               
                 GOTERM_BP_ALL 
                 GO: 0010033~response to organic substance 
                 20 
                 0.00014822 
                 2.665010428 
                 0.00558755 
               
               
                 GOTERM_BP_ALL 
                 GO: 0009617~response to bacterium 
                 9 
                 0.00015325 
                 5.756422525 
                 0.0056515 
               
               
                 GOTERM_MF_ALL 
                 GO: 0016502~nucleotide receptor activity 
                 5 
                 0.00010797 
                 19.0502451 
                 0.00582884 
               
               
                 GOTERM_MF_ALL 
                 GO: 0001614~purinergic nucleotide receptor activity 
                 5 
                 0.00010797 
                 19.0502451 
                 0.00582884 
               
               
                 GOTERM_BP_ALL 
                 GO: 0032496~response to lipopolysaccharide 
                 7 
                 0.00016853 
                 8.339914987 
                 0.00608127 
               
               
                 GOTERM_BP_ALL 
                 GO: 0045765~regulation of angiogenesis 
                 6 
                 0.00017834 
                 11.04767959 
                 0.00630065 
               
               
                 GOTERM_CC_ALL 
                 GO: 0031226~intrinsic to plasma membrane 
                 21 
                 0.00020851 
                 2.519724996 
                 0.00631924 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048513~organ development 
                 31 
                 0.00018295 
                 2.027588128 
                 0.00633147 
               
               
                 GOTERM_BP_ALL 
                 GO: 0051707~response to other organism 
                 11 
                 0.00021593 
                 4.312158809 
                 0.00731991 
               
               
                 GOTERM_BP_ALL 
                 GO: 0051270~regulation of cell motion 
                 10 
                 0.00022302 
                 4.78442817 
                 0.00741176 
               
               
                 GOTERM_BP_ALL 
                 GO: 0031099~regeneration 
                 6 
                 0.00023762 
                 10.41638362 
                 0.00774377 
               
               
                 GOTERM_MF_ALL 
                 GO: 0030246~carbohydrate binding 
                 11 
                 0.00017696 
                 4.425336439 
                 0.00834919 
               
               
                 GOTERM_CC_ALL 
                 GO: 0005887~integral to plasma membrane 
                 20 
                 0.00047736 
                 2.436305529 
                 0.01031444 
               
               
                 GOTERM_BP_ALL 
                 GO: 0030334~regulation of cell migration 
                 9 
                 0.00034868 
                 5.110842429 
                 0.01092533 
               
               
                 GOTERM_BP_ALL 
                 GO: 0051049~regulation of transport 
                 13 
                 0.00034269 
                 3.464513557 
                 0.01094009 
               
               
                 GOTERM_BP_ALL 
                 GO: 0002237~response to molecule of bacterial origin 
                 7 
                 0.00037883 
                 7.209079057 
                 0.01165013 
               
               
                 GOTERM_BP_ALL 
                 GO: 0007186~G-protein coupled receptor protein 
                 13 
                 0.00040141 
                 3.404780564 
                 0.01170574 
               
               
                   
                 signaling pathway 
                   
                   
                   
                   
               
               
                 GOTERM_BP_ALL 
                 GO: 0002697~regulation of immune effector process 
                 7 
                 0.00041534 
                 7.088927739 
                 0.01170818 
               
               
                 GOTERM_CC_ALL 
                 GO: 0016020~membrane 
                 82 
                 0.00046587 
                 1.342587724 
                 0.01173539 
               
               
                 GOTERM_BP_ALL 
                 GO: 0002822~regulation of adaptive immune response 
                 6 
                 0.00039991 
                 9.348036579 
                 0.01186565 
               
               
                   
                 based on somatic recombination of immune receptors 
                   
                   
                   
                   
               
               
                   
                 built from immunoglobulin superfamily domains 
                   
                   
                   
                   
               
               
                 GOTERM_BP_ALL 
                 GO: 0009968~negative regulation of signal transduction 
                 10 
                 0.00041443 
                 4.403060707 
                 0.01187952 
               
               
                 GOTERM_BP_ALL 
                 GO: 0044057~regulation of system process 
                 10 
                 0.00041443 
                 4.403060707 
                 0.01187952 
               
               
                 GOTERM_BP_ALL 
                 GO: 0051046~regulation of secretion 
                 8 
                 0.00039574 
                 5.85660123 
                 0.01195094 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050778~positive regulation of immune response 
                 8 
                 0.00039574 
                 5.85660123 
                 0.01195094 
               
               
                 GOTERM_BP_ALL 
                 GO: 0006935~chemotaxis 
                 8 
                 0.00045788 
                 5.718798848 
                 0.01248643 
               
               
                 GOTERM_BP_ALL 
                 GO: 0042330~taxis 
                 8 
                 0.00045788 
                 5.718798848 
                 0.01248643 
               
               
                 GOTERM_BP_ALL 
                 GO: 0002819~regulation of adaptive immune response 
                 6 
                 0.0004511 
                 9.114335664 
                 0.01250293 
               
               
                 GOTERM_BP_ALL 
                 GO: 0051101~regulation of DNA binding 
                 8 
                 0.00049175 
                 5.652301187 
                 0.01319259 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048523~negative regulation of cellular process 
                 34 
                 0.00050059 
                 1.834738973 
                 0.01321981 
               
               
                 GOTERM_BP_ALL 
                 GO: 0009653~anatomical structure morphogenesis 
                 24 
                 0.00055741 
                 2.16043512 
                 0.01448509 
               
               
                 GOTERM_BP_ALL 
                 GO: 0080134~regulation of response to stress 
                 11 
                 0.00057031 
                 3.819340659 
                 0.01459518 
               
               
                 GOTERM_MF_ALL 
                 GO: 0019955~cytokine binding 
                 7 
                 0.00035486 
                 7.312836022 
                 0.01483488 
               
               
                 GOTERM_BP_ALL 
                 GO: 0042981~regulation of apoptosis 
                 22 
                 0.00060362 
                 2.254248281 
                 0.01521241 
               
               
                 GOTERM_CC_ALL 
                 GO: 0031224~intrinsic to membrane 
                 60 
                 0.00085774 
                 1.452927379 
                 0.01617187 
               
               
                 GOTERM_BP_ALL 
                 GO: 0040012~regulation of locomotion 
                 9 
                 0.00067325 
                 4.634407965 
                 0.01670569 
               
               
                 GOTERM_BP_ALL 
                 GO: 0043067~regulation of programmed cell death 
                 22 
                 0.00068835 
                 2.231668165 
                 0.0168318 
               
               
                 GOTERM_BP_ALL 
                 GO: 0010941~regulation of cell death 
                 22 
                 0.0007188 
                 2.224241649 
                 0.01732135 
               
               
                 GOTERM_BP_ALL 
                 GO: 0010648~negative regulation of cell communication 
                 10 
                 0.00076041 
                 4.050815851 
                 0.01781109 
               
               
                 GOTERM_BP_ALL 
                 GO: 0001817~regulation of cytokine production 
                 9 
                 0.00075248 
                 4.557167832 
                 0.01787284 
               
               
                 GOTERM_BP_ALL 
                 GO: 0030154~cell differentiation 
                 28 
                 0.00084605 
                 1.942171983 
                 0.01952917 
               
               
                 GOTERM_BP_ALL 
                 GO: 0002460~adaptive immune response based on 
                 6 
                 0.00086878 
                 7.925509273 
                 0.01978057 
               
               
                   
                 somatic recombination of immune receptors built from 
                   
                   
                   
                   
               
               
                   
                 immunoglobulin superfamily domains 
                   
                   
                   
                   
               
               
                 GOTERM_BP_ALL 
                 GO: 0002250~adaptive immune response 
                 6 
                 0.00086878 
                 7.925509273 
                 0.01978057 
               
               
                 GOTERM_BP_ALL 
                 GO: 0065008~regulation of biological quality 
                 27 
                 0.00088955 
                 1.969484297 
                 0.01998171 
               
               
                 GOTERM_BP_ALL 
                 GO: 0001775~cell activation 
                 11 
                 0.0009539 
                 3.57424928 
                 0.02059711 
               
               
                 GOTERM_BP_ALL 
                 GO: 0051223~regulation of protein transport 
                 7 
                 0.00095182 
                 6.076223776 
                 0.0208168 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048869~cellular developmental process 
                 29 
                 0.00094798 
                 1.89677599 
                 0.02100365 
               
               
                 KEGG_PATHWAY 
                 hsa04621: NOD-like receptor signaling pathway 
                 7 
                 0.00076766 
                 6.125971143 
                 0.02327548 
               
               
                 GOTERM_CC_ALL 
                 GO: 0033256~I-kappaB/NF-kappaB complex 
                 3 
                 0.00140853 
                 47.9647651 
                 0.02352421 
               
               
                 GOTERM_BP_ALL 
                 GO: 0002694~regulation of leukocyte activation 
                 8 
                 0.0011427 
                 4.910079819 
                 0.02431771 
               
               
                 GOTERM_BP_ALL 
                 GO: 0050817~coagulation 
                 6 
                 0.00116213 
                 7.440274012 
                 0.02442105 
               
               
                 GOTERM_BP_ALL 
                 GO: 0007596~blood coagulation 
                 6 
                 0.00116213 
                 7.440274012 
                 0.02442105 
               
               
                 GOTERM_BP_ALL 
                 GO: 0006916~anti-apoptosis 
                 10 
                 0.00120323 
                 3.79763986 
                 0.02466543 
               
               
                 GOTERM_BP_ALL 
                 GO: 0009607~response to biotic stimulus 
                 12 
                 0.00120013 
                 3.212100675 
                 0.02490264 
               
               
                 GOTERM_BP_ALL 
                 GO: 0008285~negative regulation of cell proliferation 
                 12 
                 0.0012436 
                 3.198012514 
                 0.02517972 
               
               
                 GOTERM_MF_ALL 
                 GO: 0004930~G-protein coupled receptor activity 
                 9 
                 0.00068792 
                 4.626488095 
                 0.02574405 
               
               
                 GOTERM_CC_ALL 
                 GO: 0009986~cell surface 
                 10 
                 0.001793 
                 3.5928663 
                 0.02690939 
               
               
                 GOTERM_BP_ALL 
                 GO: 0014070~response to organic cyclic substance 
                 7 
                 0.00136752 
                 5.671142191 
                 0.02733082 
               
               
                 GOTERM_BP_ALL 
                 GO: 0040011~locomotion 
                 12 
                 0.00148086 
                 3.129385636 
                 0.02888628 
               
               
                 GOTERM_BP_ALL 
                 GO: 0070201~regulation of establishment of protein 
                 7 
                 0.0014651 
                 5.596521899 
                 0.02891444 
               
               
                   
                 localization 
                   
                   
                   
                   
               
               
                 GOTERM_BP_ALL 
                 GO: 0046649~lymphocyte activation 
                 9 
                 0.00154141 
                 4.08104582 
                 0.02971013 
               
               
                 GOTERM_BP_ALL 
                 GO: 0031328~positive regulation of cellular biosynthetic 
                 17 
                 0.00162069 
                 2.413453369 
                 0.03052477 
               
               
                   
                 process 
                   
                   
                   
                   
               
               
                 GOTERM_BP_ALL 
                 GO: 0050865~regulation of cell activation 
                 8 
                 0.00161108 
                 4.62950383 
                 0.03068591 
               
               
                 GOTERM_BP_ALL 
                 GO: 0007626~locomotory behavior 
                 9 
                 0.00169408 
                 4.02103044 
                 0.03119615 
               
               
                 GOTERM_BP_ALL 
                 GO: 0070304~positive regulation of stress-activated 
                 4 
                 0.0016835 
                 16.2032634 
                 0.03134323 
               
               
                   
                 protein kinase signaling pathway 
                   
                   
                   
                   
               
               
                 GOTERM_BP_ALL 
                 GO: 0007599~hemostasis 
                 6 
                 0.00180567 
                 6.751359751 
                 0.03286331 
               
               
                 GOTERM_BP_ALL 
                 GO: 0002706~regulation of lymphocyte mediated 
                 5 
                 0.00193607 
                 9.206399661 
                 0.03482477 
               
               
                   
                 immunity 
                   
                   
                   
                   
               
               
                 GOTERM_BP_ALL 
                 GO: 0009891~positive regulation of biosynthetic process 
                 17 
                 0.00195922 
                 2.369169821 
                 0.03486599 
               
               
                 GOTERM_BP_ALL 
                 GO: 0008284~positive regulation of cell proliferation 
                 12 
                 0.00206731 
                 3.000604334 
                 0.03637597 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048522~positive regulation of cellular process 
                 34 
                 0.00209766 
                 1.68922002 
                 0.03652324 
               
               
                 GOTERM_BP_ALL 
                 GO: 0043433~negative regulation of transcription factor 
                 5 
                 0.00216669 
                 8.9356232 
                 0.03732224 
               
               
                   
                 activity 
                   
                   
                   
                   
               
               
                 GOTERM_BP_ALL 
                 GO: 0051098~regulation of binding 
                 8 
                 0.00221714 
                 4.379260379 
                 0.03741874 
               
               
                 GOTERM_BP_ALL 
                 GO: 0010646~regulation of cell communication 
                 22 
                 0.00220111 
                 2.034656363 
                 0.0375249 
               
               
                 GOTERM_BP_ALL 
                 GO: 0048568~embryonic organ development 
                 7 
                 0.0023046 
                 5.124526076 
                 0.03848637 
               
               
                 GOTERM_MF_ALL 
                 GO: 0004896~cytokine receptor activity 
                 5 
                 0.0013647 
                 10.12044271 
                 0.04596231 
               
               
                 GOTERM_BP_ALL 
                 GO: 0045944~positive regulation of transcription from 
                 11 
                 0.00298615 
                 3.065984474 
                 0.04864968 
               
               
                   
                 RNA polymerase II promoter 
                   
                   
                   
                   
               
               
                 GOTERM_BP_ALL 
                 GO: 0043392~negative regulation of DNA binding 
                 5 
                 0.00297111 
                 8.211113211 
                 0.04887781 
               
               
                 GOTERM_CC_ALL 
                 GO: 0016021~integral to membrane 
                 56 
                 0.00368755 
                 1.398972315 
                 0.04976835 
               
               
                 GOTERM_BP_ALL 
                 GO: 0032880~regulation of protein localization 
                 7 
                 0.00309631 
                 4.833359822 
                 0.04992419 
               
               
                   
               
             
          
         
       
     
         [0428]    These pathways include a variety of immune related pathways expected to be relevant to Copaxone&#39;s mechanism of action, including immune-related pathways such as the cytokine-cytokine receptor interaction pathway (adjusted p&lt;1.9e-5) that was also enriched among probesets modulated by Copaxone® (see above), and positive regulation of cytokine production (adjusted p&lt;0.004). These pathways also include inflammation related pathways, such as inflammatory response (adjusted p&lt;0.0001), NOD-like receptor signaling (adjusted p&lt;0.02), and response to lipopolysaccharide (adjusted p&lt;0.006). The top 25 pathways are listed in Table 30, and the key pathways are illustrated in  FIG. 38 . The specific genes in the cytokine-cytokine receptor interaction pathway are depicted in  FIG. 39 . 
         [0000]    
       
         
               
             
               
               
               
               
             
               
               
               
               
             
           
               
                 TABLE 30 
               
             
             
               
                   
               
               
                 Top 25 pathways significantly enriched among top probesets 
               
               
                 differentially expressed between Polimunol and Copaxone 
               
             
          
           
               
                   
                   
                   
                 Adjusted 
               
               
                 Category 
                 Term 
                 Count 
                 p value 
               
               
                   
               
             
          
           
               
                 GO Biological Process 
                 GO: 0009605~response to external 
                 34 
                 2.13E−09 
               
               
                   
                 stimulus 
                   
                   
               
               
                 GO Biological Process 
                 GO: 0050896~response to stimulus 
                 66 
                 1.25E−08 
               
               
                 GO Biological Process 
                 GO: 0009611~response to wounding 
                 24 
                 6.26E−08 
               
               
                 GO Biological Process 
                 GO: 0051239~regulation of 
                 30 
                 1.22E−06 
               
               
                   
                 multicellular organismal process 
                   
                   
               
               
                 GO Biological Process 
                 GO: 0006950~response to stress 
                 45 
                 1.35E−06 
               
               
                 GO Cellular 
                 GO:0005576~extracellular region 
                 32 
                 2.46E−06 
               
               
                 Compartment 
                   
                   
                   
               
               
                 GO Biological Process 
                 GO: 0002376~immune system 
                 31 
                 2.79E−06 
               
               
                   
                 process 
                   
                   
               
               
                 GO Molecular Function 
                 GO: 0004888~transmembrane 
                 21 
                 9.08E−06 
               
               
                   
                 receptor activity 
                   
                   
               
               
                 GO Molecular Function 
                 GO: 0004872~receptor activity 
                 30 
                 1.15E−05 
               
               
                 GO Biological Process 
                 GO: 0006955~immune response 
                 23 
                 1.51E−05 
               
               
                 Kegg Pathway 
                 hsa04060: Cytokine-cytokine 
                 14 
                 1.92E−05 
               
               
                   
                 receptor interaction 
                   
                   
               
               
                 GO Molecular Function 
                 GO: 0004871~signal transducer 
                 37 
                 2.09E−05 
               
               
                   
                 activity 
                   
                   
               
               
                 GO Molecular Function 
                 GO: 0060089~molecular transducer 
                 37 
                 2.09E−05 
               
               
                   
                 activity 
                   
                   
               
               
                 GO Biological Process 
                 GO: 0006952~defense response 
                 21 
                 2.37E−05 
               
               
                 GO Biological Process 
                 GO: 0032879~regulation of 
                 22 
                 2.98E−05 
               
               
                   
                 localization 
                   
                   
               
               
                 GO Molecular Function 
                 GO: 0030247~polysaccharide 
                 10 
                 4.04E−05 
               
               
                   
                 binding 
                   
                   
               
               
                 GO Molecular Function 
                 GO: 0001871~pattern binding 
                 10 
                 4.04E−05 
               
               
                 GO Cellular 
                 GO: 0005615~extracellular space 
                 17 
                 5.17E−05 
               
               
                 Compartment 
                   
                   
                   
               
               
                 GO Biological Process 
                 GO: 0048583~regulation of response 
                 19 
                 5.23E−05 
               
               
                   
                 to stimulus 
                   
                   
               
               
                 GO Cellular 
                 GO: 0044421~extracellular region 
                 19 
                 9.73E−05 
               
               
                 Compartment 
                 part 
                   
                   
               
               
                 GO Cellular 
                 GO: 0005886~plasma membrane 
                 51 
                 0.00010059 
               
               
                 Compartment 
                   
                   
                   
               
               
                 GO Biological Process 
                 GO: 0050794~regulation of cellular 
                 97 
                 0.000107777 
               
               
                   
                 process 
                   
                   
               
               
                 GO Biological Process 
                 GO: 0042127~regulation of cell 
                 25 
                 0.000107884 
               
               
                   
                 proliferation 
                   
                   
               
               
                 GO Biological Process 
                 GO: 0007166~cell surface receptor 
                 30 
                 0.000108003 
               
               
                   
                 linked signal transduction 
                   
                   
               
               
                 GO Biological Process 
                 GO: 0006954~inflammatory 
                 15 
                 0.000114601 
               
               
                   
                 response 
               
               
                   
               
             
          
         
       
     
       Polimunol and Copaxone Comparison: Discussion 
       [0429]    Once demonstrated to be robustly designed as shown in the MoA sub-section, and upon applying conservative statistical approaches, hundreds of genes are differentially expressed in human monocytes following activation with Polimunol compared to activation with Copaxone®. In and of itself, the fact that so many genes are differentially expressed immediately calls into question the “sameness” of Polimunol and suggests that its biological impact on human antigen presenting cells differs significantly from Copaxone®. This stands in sharp contrast to the lack of differences between the three different lots of Copaxone tested in parallel, under blinding, in the same experiment (in the three possible pairwise comparisons between Copaxone® lots, for two of the comparisons zero significant probesets were observed, and for the third a single probeset passed FDR with adjusted p value of 0.044). Moreover, the fact that the differentially expressed genes are enriched in key biological pathways such as “immune response” further supports the biological relevance of the observed differences. Finally, the fact that many of the pathways enriched among the differentially expressed genes are relevant to Copaxone&#39;s mechanism of action, such as cytokine-cytokine receptor interactions, and relevant to potential safety concerns, such as inflammatory response and response to lipopolysaccharide pathways, together raise serious concerns regarding the safety and efficacy of Polimunol. In fact, the response to lipopolysaccharide pathway was also enriched among genes differentially expressed by another purported generic, Probioglat ( FIG. 40 ). Out of the 137 pathways enriched among probesets upregulated by Polimunol relative to Copaxone®, 37 of these pathways were also enriched in the prior comparison with Probioglat (out of 64 total pathways seen for Probioglat). Of note, the introduction of Probioglat in Mexico was associated with a 3-fold increase in adverse events and a 7-fold increase in relapses as detailed in Teva&#39;s seventh Citizen Petition (FDA-2014-P-0933-0001 available at www.regulations.gov/#?documentDetail;D=FDA-2014-P-0933-0001, and also described herein). 
       Discussion 
     Example 10-11 
       [0430]    Copaxone® has long provided a safe and effective treatment option for multiple sclerosis patients, operating through a complex set of mechanisms that have gradually been elucidated through extensive research that continues to this day. 
         [0431]    Methods for comparing two small molecule medicines to determine therapeutic equivalence are well established, and standards for evaluating biologics are also rapidly becoming available. However, for non-biological complex drugs (NBCDs) such as glatiramer acetate the level of evidence needed to determine equivalence remains an unresolved question and a subject of ongoing research by the scientific community. Teva is an active participant in such research, conducting a steady program of experiments to characterize Copaxone® and compare it to various glatiramoids marketed outside the United States and Europe as purported generics. Such characterization studies are critical to ensure that patients with multiple sclerosis (MS) continue to receive adequate medicines that are efficacious and safe. 
         [0432]    One key aspect of the public discourse on non-biological complex drugs concerns the role of clinical trials. Well-controlled clinical trials of appropriate duration (typically 2 years) using standard endpoints such as annualized relapse rate (ARR) are an important means for investigating the safety and efficacy of medicines for MS, yet clinical studies not meeting those criteria distract from the essential question of “sameness” and risk creating a false sense of security for a purported generic. In recent months, Synthon has publicly reported clinical results for a follow-on glatiramoid purported to be a generic form of Copaxone, yet the trial results raise significant questions regarding its validity [as detailed in Appendix 2 of FDA-2014-P-0933-0001 available at www.regulations.gov/#?documentDetail;D=FDA-2014-P-0933-0001, and also described herein]. For instance, given the sample size of GATE (Copaxone=357, Placebo=84), the probability of showing any level of annualized relapse rate (ARR) reduction (i.e. clinical efficacy) in the reference, well-established drug Copaxone®, using results from prior adequate, randomized, placebo-controlled studies with Copaxone® was high (&gt;90%). Yet, a statistically unlikely result of no effect in reducing ARR was recorded for the Copaxone® arm in the GATE study, attesting to the lack of assay sensitivity. It is critical to know whether the trial had assay sensitivity (i.e., could have distinguished an effective drug from an ineffective one). Thus, if the active control (Copaxone® in the case of GATE study) had no effect at all in the trial (i.e., did not have any of its well-established, expected effect), then finding even a very small difference between control and test drug is meaningless, providing no evidence that the test drug is effective. Lastly, the rate of adverse events leading to discontinuation was 2.4 fold higher in the Synthon product arm than in the Copaxone® arm (12 vs 5). Overall, the many shortcomings of the design and conduct of the GATE study render its findings unreliable. 
         [0433]    Teva is continuously conducting experiments to further elucidate Copaxone®&#39;s complex mechanism of action, and working towards the discovery of validated biomarkers, which have yet to be identified. Teva then seeks to compare Copaxone®&#39;s profile to that of all purported generics marketed globally. Synthon&#39;s Polimunol was recently introduced to clinical practice in Argentina, and has since been studied by Teva extensively through a variety of characterization methods, each providing a small window into specific characteristics of this complex medicine. For instance, genome-wide transcriptional studies were employed in carefully selected model systems informative of certain aspects of the biological impact of an immunological medicine. To compare the ex-vivo biological effect of Copaxone® and Polimunol in mouse lymphocytes following prior in vivo immunization, mouse splenocytes were utilized, which embody the key cell type impacted by antigenic presentation. Additionally, to compare the immediate biological effects of Copaxone® and Polimunol in antigen-presenting cells, which are key to the mode of action of an antigen in mediating T-helper cell immune response, a human monocyte (THP-1) cell line was utilized. In both model systems significant differences in gene expression profiles were detected between Copaxone and Polimunol, regardless of the immunization sequence or array randomization scheme. 
         [0434]    In mouse splenocytes, the fact that significant and consistent differences in gene expression profiles are observed between splenocytes ex-vivo activated with Polimunol and splenocytes activated with Copaxone®, regardless of whether the mice were initially in vivo immunized with Copaxone or initially immunized with Polimunol, further emphasizes the robustness of the differences in biological impact of these two medicines on many genes. These hundreds of affected genes participate in immunologically relevant pathways and highlight potential clinical implications of overly stimulated or under-regulated immunological mechanisms relevant to the response and well-being of MS patients. For instance, IL18, which has been implicated in the pathogenesis of MS, is downregulated significantly less effectively by Polimunol than by Copaxone. IL18 is important for T helper cell differentiation, and influences IFNg expression, suggesting that the impact of each medicine on T cells (which play an important role in Copaxone&#39;s mechanism of action) is significantly different. The importance of IL18 via its actions in inducing Th1 responses (which is attributed, at least partially, to induction of IFNg production by natural killer (NK) cells), was underscored in a study in the mouse model of MS, autoimmune encephalomyelitis (EAE). Mice deficient for IL18 were observed to be resistant to EAE, and treatment of these mice with IL18 restored the ability to generate a Th1 response, while treatment of mice wild-type for IL18 increased EAE disease severity (Shi et al, J. Immunol., 2000). IL18 antibodies as well as the naturally expressed IL18 inhibitor, IL18BP (which was upregulated by Copaxone treatment in this study), have been proposed as potential therapeutic agents against neuroinflammation (Felderhoff-Mueser et al, Trends Neurosci, 2005). 
         [0435]    Similarly, key type I interferon pathway production pathway genes including RIG-I, MDA5, and IRF7 are all significantly upregulated by Polimunol relative to Copaxone®. This increased interferon signaling with Polimunol treatment further increases concerns about possible adverse events including flu-like symptoms in Polimunol-treated patients. As noted in Trinchieri et al, 2010, “IFN produced during viral infection, other pathological conditions, or in the presence of DNA released by dying cells may mediate unwanted toxicity or induce pathological damage and inflammatory or autoimmune syndromes (Pascual et al., 2010).” 
         [0436]    In human monocytes, many of the pathways enriched among the genes differentially expressed between Copaxone and Polimunol are relevant to Copaxone&#39;s mechanism of action (such as cytokine-cytokine receptor interaction), and relevant to potential safety concerns (such as inflammatory response and response to lipopolysaccharide pathways). The same response to lipopolysaccharide pathway was also enriched among genes differentially expressed by another purported generic, Probioglat. This is particularly concerning because the introduction of another purported generic to Copaxone, Probioglat in Mexico was associated with a 3-fold increase in adverse events and a 7-fold increase in relapses as detailed in Teva&#39;s seventh Citizen Petition (FDA-2014-P-0933-0001 available at www.regulations.gov/#?documentDetail;D=FDA-2014-P-0933-0001, and also described herein). 
         [0437]    The gene expression findings suggest that regardless of the many issues in the design and conduct of Synthon&#39;s GATE study that render the results unreliable, the study itself was premature because it was conducted on a glatiramoid that is almost certainly not equivalent to Copaxone®. Together, these data warrant further investigation, and emphasize the need for clinical trials following upon the establishment of quality and pharmaceutical equivalence, specifically multi-year safety studies with standard clinical endpoints for MS, to ensure the safety and well-being of multiple sclerosis patients. 
         [0438]    How best to determine whether a differently manufactured glatiramoid is as safe and effective as Copaxone® remains an unresolved question that is also the subject of active research. One such differently manufactured glatiramoid, Synthon&#39;s Polimunol, purports to have been tested in a clinical study (GATE), yet the trial results are of questionable validity and raise more questions than answers, as detailed in Appendix 2 of FDA-2014-P-0933-0001 available at www.regulations.gov/#?documentDetail;D=FDA-2014-P-0933-0001, and also described herein]. Beyond the extensive flaws in the design and conduct of the GATE study that render the results unreliable, the study itself was premature because the equivalence of Synthon&#39;s glatiramoid with Copaxone® had not been conclusively established, and data from a full battery of high resolution physicochemical and gene expression studies support the conclusion that Sython&#39;s glatiramoid and Copaxone® are not equivalent. 
         [0439]    The newest gene expression studies first reported in this document find extensive and significant differences between the gene expression profiles modulated by Synthon&#39;s Polimunol and the profiles modulated by Copaxone®, in both human monocytes and mouse splenocytes. Both of these studies employ a whole genome based approach, looking across the entire expression array in an unbiased fashion, in model systems capturing differing, relevant aspects of Copaxone® effect. 
         [0440]    In mouse splenocytes, 223 probesets were significantly differentially expressed between Copaxone® and Polimunol in Copaxone®-immunized mice, and 431 probesets were significantly differentially expressed between Copaxone® and Polimunol in Polimunol-immunized mice. In both immunization conditions, IL18 was downregulated to a significantly greater extent by Copaxone® than Polimunol, raising concerns about Polimunol&#39;s reduced effectiveness in suppressing this MS-associated cytokine. As described above, IL18 is known to affect helper T cell differentiation, an important aspect of Copaxone&#39;s mechanism of action, and to induce IFNg expression, and has been implicated in MS pathogenesis. IL18 induces proinflammatory Th1 responses and has been implicated in a number of neurodegenerative and neuroinflammatory contexts including MS (Felderhoff-Mueser et al, Trends Neurosci, 2005). 
         [0441]    The probesets differentially expressed between Copaxone® and Polimunol enriched to 22 pathways for Copaxone® immunization, and 10 pathways for Polimunol immunization. Many of these pathways overlapped, including immune response and response to virus. The fact that there are many significant differences between the gene expression patterns induced in splenocytes by Polimunol and Copaxone, regardless of whether those splenocytes are from mice immunized with Polimunol or with Copaxone®, further emphasizes the robustness of the observed differences between these two medicines. Moreover, Polimunol upregulates a number of interferon-related genes, including RIG-I, MDA5, and IRF7, suggesting the possibility of increased type I interferon signaling with Polimunol treatment. An increase in type I interferon is concerning, and could lead to possible adverse events such as flu-like symptoms. 
         [0442]    In human monocytes, 779 probesets were differentially expressed, with 137 pathways enriched among the probesets upregulated by Polimunol relative to Copaxone®. Differentially expressed genes included CYP1B1 and IL1B, and the pathways enriched among the differentially expressed probesets included cytokine-cytokine receptor interactions and response to lipopolysaccharide. The enrichment in the response to lipopolysaccharide (LPS) pathway is particularly concerning, because the same prototypic pro-inflammatory pathway was also enriched among genes differentially expressed by the purported generic Probioglat, and the introduction of Probioglat in Mexico was associated with a 3-fold increase in adverse events (and a 7-fold increase in relapses) as described in Teva&#39;s seventh Citizen Petition (FDA-2014-P-0933-0001 available at www.regulations.gov/#?documentDetail;D=FDA-2014-P-0933-0001, and also described herein). Whether a similar phenomenon potentially underlies the higher adverse event rate (˜2.4-fold increase) observed in Synthon&#39;s GATE trial warrants further investigation. 
         [0443]    Taken together, the new data introduced here demonstrates that the genes and pathways modulated by Synthon&#39;s Polimunol differ significantly and extensively from those modulated by Copaxone®. These data are in line with Teva&#39;s report of significant differences observed in various state-of-the-art physicochemical analyses detailed in a November comment to CP Docket FDA-2014-P-0933 (available at www.noticeandcomment.com/FDA-2014-P-0933-fcol-41234.aspx). 
         [0444]    The biology underlying the differences detailed herein provide potential mechanistic hypotheses for differential efficacy and for the increase in adverse events leading to discontinuations as reported by Synthon with Polimunol relative to Copaxone® in the GATE study. Several striking biological differences stand out including levels of inflammatory cytokine genes such as IL18, interferon genes, and pro-inflammatory pathways such as response to lipopolysaccharide. These findings warrant further investigation, and raise substantial concerns for the safety and well-being of patients treated with Synthon&#39;s Polimunol. The data further illustrates the imminent need for guidelines specific to NBCD, and specifically to glatiramoids. The gene expression changes described in this document, together with physicochemical differences between Polimunol and Copaxone® described in a Nov. 13, 2014 comment to CP Docket FDA-2014-P-0933-0020 (available at www.noticeandcomment.com/FDA-2014-P-0933-fcol-41234.aspx), support the conclusion that Synthon&#39;s Polimunol is not therapeutically equivalent or similar to Copaxone®. 
         [0445]    More generally, to establish whether a follow on glatiramoid has comparable safety and effectiveness to Copaxone®, it must first be established that the glatiramoid is the same as Copaxone® using a full battery of orthogonal methodologies including assays that detect high-resolution physicochemical properties and functionally relevant biological properties, including genome-wide gene expression analyses in immunologically relevant model systems including systems modeling antigen presenting cells and systems modeling T cells. Only when an applicant has demonstrated equivalence on these biological and physicochemical methods should they proceed to establish therapeutic comparability through an adequately powered, at least 2-year clinical trial using a widely accepted clinical endpoint such as annualized relapse rate. 
       Example 12 
     Gene Expression Studies of a Human Monocyte Cell Line Identify Dissimilarities Between Differently Manufactured Glatiramoids 
       [0446]    Protein Levels at 24h are Consistent with Upregulation of Pro-Inflammatory mRNA Markers by Probioglat Versus GA Treatment at 6h 
         [0447]    Protein concentration was tested in the same experiment at the 24h timepoint in order to validate upregulation of pro-inflammatory markers by Probioglat versus GA. Taking into consideration the fact that differences observed at the mRNA level do not necessarily translate to protein concentration differences, and may reflect regulatory processes, a Luminex kit measuring the concentrations of a panel of 45 chemokines and cytokines (in pg/ml) was employed. The Bio-Plex Human Chemokine (Bio Rad kit) and the Luminex Performance Assay (R&amp;D kit) were utilized. Protein concentrations were measured in a single replicate at 24 hours, a timepoint estimated to correspond to the time when the mRNA signals observed at 6 hours may have been translated to protein. Of the five genes tested by qRT-PCR, three were represented on the Luminex panel: CCL5, CXCL10, and MMP9. All three showed higher concentrations in the Probioglat samples than the GA samples (fold changes 1.5, 2.3, and 1.4, respectively;  FIG. 45 ) consistent with the directionality of the gene expression data ( FIGS. 4A-D ). Two other genes discussed above, IL10 and CCL2, were also present on the Luminex panel and also showed higher concentration levels in Probioglat relative to GA (fold changes 1.8 and 1.3, respectively;  FIG. 45 ), consistent with the directionality observed at the mRNA level ( FIG. 41 d - e   ). 
         [0000]    Key Genes Upregulated by Probioglat Compared to GA were Validated in Primary Human Monocytes 
         [0448]    While immortalized cell lines are widely utilized in biological research and provide various advantages including uniformity and accessibility, it is important to confirm that the changes introduced by the immortalization process do not alter the key results. Therefore, top findings from the expression data were further tested in primary monocytes from healthy human donors using the sensitive method of qRT-PCR. Nine genes (CCL2, CCL5, CXCL10, MMP1, MMP9, CD9, ICAM1, IL10, IL1RN) were chosen for testing based on the findings reported above from the THP-1 monocyte cell line. In primary monocytes from a healthy donor with 6 replicates, the majority of the tested genes exhibited the expected directionality of expression differences between Probioglat and GA. Five of these nine genes passed statistical significance ( FIG. 42 ). These genes included IL1RN, and the pro-inflammatory CCL2, CCL5, CXCL10 and MMP9 (p values&lt;0.01 and 0.009, 0.029, 0.02, and 0.009, respectively). 
       Discussion 
     Example 12 
       [0449]    Protein concentrations tested in the same experiment at the 24h timepoint were consistent with the findings observed at the mRNA level, supporting the reported findings and indicating an inflammation-related biological impact at the protein level. An independent follow-on study in primary human monocytes tested nine inflammation and MS-related genes by qRT-PCR, finding that five of these genes were statistically significantly upregulated by Probioglat relative to GA. These included IL1RN, which is relevant to Copaxone mechanism of action. In addition, CCL2, CCL5, CXCL10, and MMP9 were all seen to be upregulated significantly and consistently at both the mRNA and protein level in THP-1 cells, as well as confirmed by qRT-PCR in primary human monocytes. These genes act in pro-inflammatory pathways and have been implicated as relevant to MS susceptibility and severity, as described above. 
         [0450]    The complex picture of genomic signatures described here underscores the intricate relationships between immune processes, effects of treatment on the associated pathways and the differing responses of each immune cell type. Consistent with previous evidence from other systems and cell types (Huang et al, Nucleic Acids Res. 2009), differences are consistently observed between GA and differently-manufactured glatiramoids, although their nature depends on the biological context of the tested model. Further, many of these differences affect molecules relevant to drug MOA and MS disease pathoetiology, particularly relating to inflammatory signatures. Genes significantly upregulated by Probioglat relative to GA were significantly enriched for inflammatory pathways and included key pro-inflammatory genes. 
         [0451]    These findings have identified significant differences that warrant further investigation, especially in light of the observed clinical effects of Probioglat&#39;s introduction. The Teva Patient Support Program in Mexico records numbers of adverse events, including during the years 2012 and 2013 (Table 31;  FIG. 46 ), for which a similar number of patients were tracked (1618 patients in 2012; 1552 in 2013). Probioglat was first introduced in January 2013; subsequently, each time a patient&#39;s prescription was filled, it could be with either Probioglat or GA. In 2013 versus 2012 (during which only branded GA was marketed), numbers of adverse events, and relapses specifically, increased more than 3-fold (from 125 to 380) and 7-fold (from 8 to 59), respectively (Table 31;  FIG. 46 ), representing statistically-significant increases (p&lt;2.2e-29 and p&lt;3e-11, respectively). The gene-expression differences observed herein warrant careful investigation, through studies comparing GA to candidate generics in meaningful settings, most comprehensively including clinical trials. 
         [0000]    
       
         
               
             
               
               
               
               
             
               
               
               
               
             
           
               
                 TABLE 31 
               
             
             
               
                   
               
               
                 Reported Adverse Events and Relapses in Teva&#39;s Patient 
               
               
                 Support Program, 2012-2013. 
               
             
          
           
               
                   
                 2012 
                 2013 
                 Statistical Significance 
               
               
                   
                 (Copaxone 
                 (Probioglat + 
                 of Increase 
               
               
                   
                 alone) 
                 Copaxone) 
                 from 2012 to 2013 
               
               
                   
               
             
          
           
               
                 Adverse Events 
                 125 
                 380 
                 p &lt; 2.2e−29* 
               
               
                 Adverse Event Rate 
                 10.4 
                 31.7 
                   
               
               
                 (per month) 
                   
                   
                   
               
               
                 Relapses 
                 8 
                 59 
                 p &lt; 3e−11* 
               
               
                 Relapse Rate (per 
                 0.7 
                 4.9 
                   
               
               
                 month) 
                   
                   
                   
               
               
                 Total Number of 
                 1618 
                 1552 
                   
               
               
                 Patients in Teva&#39;s 
                   
                   
                   
               
               
                 Patient Support 
                   
                   
                   
               
               
                 Program 
               
               
                   
               
               
                 *Single tailed p-value by Fisher&#39;s Exact test comparing the number of adverse events and relapses in 2012 &lt; 2013. 
               
             
          
         
       
     
       Example 13 
     Validation of Key mRNA-Based Findings by Secreted Protein Analyses 
       [0452]    To evaluate effects of Copaxone at the protein level, and assess the extent to which differences observed at the mRNA level (using micaroarry and qRT-PCR) were further consistent with effects observed at the level of the translated proteins, levels of 42 secreted cytokines and chemokines were measured using Luminex technology, analyzing the supernatant of THP-1 cells (human monocyte cell line) stimulated for 24 hours with Copaxone, FOGA, or mannitol control. 
         [0453]    After applying statistical significance threshold, Synthon&#39;s Polimunol treatment increased the levels of 23 proteins (out of 39 having sufficient measurements to test for this comparison) relative to Copaxone, while Probioglat treatment increased the levels of 31 proteins (out of 40 having sufficient measurements to test for this comparison) relative to Copaxone (Table 32). 
       Secreted Protein Analyses 
       [0454]    Measurements were also undertaken at the protein level, in order to assess the biological relevance of the observed gene expression differences. Levels of a panel of secreted cytokines and chemokines were measured via Luminex from THP-1 cells stimulated with branded GA, Polimunol, or Probioglat. 
         [0455]    Cells from the THP-1 human monocyte cell line were incubated with branded GA, FOGA (Polimunol or Probioglat), or vehicle control (mannitol) for 24 hours. This time point was chosen in order to reflect translation of mRNA expression patterns observed in the same study design at 6 hours post stimulation. Supernatants were collected and assayed for the concentration of selected proteins using a Luminex assay. A total of 5 biological replicates per condition were utilized. 
         [0456]    Data (concentrations in pg/mL) were compared using a two-sided t-test with equal variance, and corrected for multiple hypothesis testing using Benjamini-Hochberg correction. To calculate the fold change between the protein expression levels with FOGA and with GA, GA values were averaged together and compared to the average value for FOGA (average FOGA expression level/average GA expression level). 
       Polimunol Versus Copaxone 
       [0457]    Polimunol treatment significantly increased the levels of 23 proteins (out of 39 having sufficient measurements to test for this comparison). These include IFNg, TNFa, MIP-1a (CCL3), IL-8 (CXCL8), and IL-10 ( FIG. 47 ; adjusted p values as shown). Many of these proteins were also increased in level by Copaxone treatment relative to mannitol control. Consistent with the result observed at the mRNA expression level, secreted levels of MMP-9, MCP-1 (CCL2), RANTES (CCL5), Gro-a (CXCL1), and IL-1b were increased with Polimunol treatment relative to GA ( FIG. 48 ; adjusted p values as shown). Of note, CCL2 was not modulated by GA relative to control, while it was increased by Polimunol treatment relative to GA. 
         [0458]    A number of important differences in secreted protein level are observed for Polimunol relative to Copaxone, including levels of IFNg, TNFa, IL-8, and MIP-1a. IFNg is the major cytokine that drives the pro-inflammatory Th1 T-cell response, and is both implicated in MS and known to be relevant to Copaxone mechanism of action (Gilli et al 2012; Tumani et al 2011). TNFa is a major cytokine directing inflammatory responses, and polymorphisms in this gene have been reported to influence MS susceptibility (Rahmanian et al, 2014). The chemokine IL-8 (CXCL8) has been implicated in MS disease progression and risk, and proposed as a biomarker for MS (Lund et al, 2004; Kelland et al, 2011; Almasi et al, 2013; Tomioka et al, 2014). MIP-1a (Macrophage Inflammatory Protein 1-alpha; CCL3) is another proinflammatory chemokine with relevance to MS (Zhang et al, Brain, 2000; Aung et al, 2010). 
         [0459]    Differences are also observed in the level of secreted IL-10. IL-10 is an anti-inflammatory cytokine important for Th2 polarization, and has been implicated in the mechanism of action of Copaxone (Vieira at al. Glatiramer acetate (copolymer-1, copaxone) promotes Th2 cell development and increased IL-10 production through modulation of dendritic cells. J. Immunol. 1950 170, 4483-4488 (2003); Kim, H. J. et al. Type 2 monocyte and microglia differentiation mediated by glatiramer acetate therapy in patients with multiple sclerosis. J. Immunol. 1950 172, 7144-7153 (2004); Weber, M. S. et al. Type II monocytes modulate T cell-mediated central nervous system autoimmune disease. Nat. Med. 13, 935-943 (2007)). 
         [0460]    The observed differences in levels of each of these five proteins with Polimunol versus Copaxone treatment confirm the gene level reports by microarray as described (Kolitz et al, Sci Rep, 2015, in press). As detailed above, CCL2 and RANTES (CCL5) are inflammatory chemoattractants with known relevance to MS (Allie et al 2005; Mahad et al 2006), and MMP-9 is a pro-inflammatory matrix metalloproteinase extensively implicated in MS (Rosenberg 2005; Romme Christensen et al 2013; Kouwenhoven et al 2002; Waubant et al 2006; Milward et al 2008). The biological relevance of these genes is discussed at length in Section 6.2. Gro-a (CXCL1) is another chemokine implicated in MS and MS models (Glabinski et al 1998; Rumble et al, J Exp Med, 2015), and IL-1b is a proinflammatory cytokine important for inflammasome signalling, with numerous connections to MS in the literature (Prins et al 2013; Rossi et al 2014; Murta et al 2015). 
         [0461]    Overall the proteomic data complements the microarray data and confirms the robustness of the detected signatures. These observations substantiate the concerns raised by upregulation of proinflammatory cytokines and associated pathways. 
       Probioglat Versus Copaxone 
       [0462]    Key differences between Probioglat and Copaxone were identified using microarray in THP-1 cells, then tested in primary monocytes, confirming the relevance of the cell line model. To see whether these gene expression differences translated into differences at the protein level, indicating biological relevance, secreted protein levels were measured from THP-1 cells treated with Copaxone or Probioglat. 
         [0463]    Probioglat treatment significantly increased the levels of 31 proteins (out of 40 having sufficient measurements to test for this comparison). These include IFNg, TNFa, MIP-1a (CCL3), IL-8 (CXCL8), and IL-10 ( FIG. 49 ; adjusted p values as shown). The clear biological relevance of these proteins to disease or to GA response is also described above. Many of these proteins were also increased in level by GA treatment relative to mannitol control. Consistent with results observed at the mRNA expression level (Kolitz et al, Sci Rep 2015, in press), the 31 proteins also include MMP-9, IP-10 (CXCL10), MCP-1 (CCL2) and RANTES (CCL5) ( FIG. 50 ; adjusted p values as shown). Of note, CCL2 was not modulated by GA relative to control, while it was increased by Probioglat treatment relative to GA. 
         [0464]    Secreted levels of several key proteins were observed to differ with Probioglat treatment relative to Copaxone, including IFNg, TNFa, IL-8, and MIP-1a. As discussed in the previous section, each of these genes has important roles in inflammation and/or MS (Gilli et al 2012; Tumani et al 2011; Rahmanian et al, 2014; Lund et al, 2004; Kelland et al, 2011; Almasi et al, 2013; Tomioka et al, 2014; Zhang et al, Brain, 2000; Aung et al, 2010). The level of secreted IL-10 also differs between Probioglat and Copaxone treatment. As described in the previous section, IL-10 is an anti-inflammatory cytokine important for Th2 polarization, and implicated in Copaxone mechanism of action (Vieira at al. 2003; Kim, H. J. et al. 2004; Weber, M. S. et al. 2007). 
         [0465]    As described above, CCL2, RANTES (CCL5) and IP-10 (CXCL10) are all inflammatory chemoattractants with relevance to MS (Allie et al 2005; Mahad et al 2006; Peperzak et al 2013; Thamilarasan et al 2013), and MMP-9 is a pro-inflammatory matrix metalloproteinase implicated in MS (Rosenberg 2005; Romme Christensen et al 2013; Kouwenhoven et al 2002; Waubant et al 2006; Milward et al 2008). As described in FDA-2014-P-0933; Kolitz et al, Sci Rep, 2015, in press; and above, the genes coding for these proteins were also demonstrated to be induced to differing degrees by Probioglat and Copaxone in both the THP-1 model system and in primary human monocytes. The biological relevance of these genes is discussed at length above. 
         [0466]    Thus, the protein analyses further supported the observation of inflammation-related differences between Probioglat and Copaxone, consistent with the clinical observations of increased rates of adverse events and relapses. 
         [0000]    
       
         
               
             
               
               
               
             
               
               
               
               
               
             
               
               
               
               
               
               
               
               
             
           
               
                 TABLE 32 
               
             
             
               
                   
               
               
                 Proteins and genes significantly differentially expressed 
               
               
                 between Polimunol and Copaxone ® treatment and between 
               
               
                 Probioglat and Copaxone ® treatment in THP-1 human monocytes. 
               
             
          
           
               
                   
                 Polimunol vs Copaxone 
                 Probioglat vs Copaxone 
               
             
          
           
               
                   
                 Gene 
                 Benjamini 
                   
                 Benjamini 
               
             
          
           
               
                 Protein 
                 symbol 
                 FC 
                 p. value 
                 p value 
                 FC 
                 p. value 
                 p value 
               
               
                   
               
               
                 MIP-1a 
                 CCL3 
                 1.37 
                 3.59E−09 
                 1.40E−07 
                 1.56 
                 1.58E−11 
                 5.62E−10 
               
               
                 MMP-9 
                 MMP9 
                 1.42 
                 8.69E−09 
                 1.69E−07 
                 1.44 
                 7.40E−09 
                 3.70E−08 
               
               
                 MDC 
                 CCL22 
                 1.13 
                 1.63E−07 
                 2.12E−06 
                 1.24 
                 2.81E−11 
                 5.62E−10 
               
               
                 CCL24 
                 CCL24 
                 1.15 
                 2.39E−07 
                 2.33E−06 
                 1.25 
                 2.31E−10 
                 2.84E−09 
               
               
                 CX3CL1 
                 CX3CL1 
                 1.28 
                 2.28E−06 
                 1.78E−05 
                 1.64 
                 3.15E−09 
                 1.80E−08 
               
               
                 MIP-3a 
                 CCL20 
                 1.28 
                 4.73E−06 
                 2.65E−05 
                 1.72 
                 2.84E−10 
                 2.84E−09 
               
               
                 MCP-1 
                 CCL2 
                 1.16 
                 4.75E−06 
                 2.65E−05 
                 1.26 
                 2.48E−05 
                 5.23E−05 
               
               
                 TNF-a 
                 TNF 
                 1.23 
                 1.16E−05 
                 5.64E−05 
                 1.29 
                 7.81E−07 
                 2.08E−06 
               
               
                 IL-8 
                 IL8 
                 1.21 
                 2.40E−05 
                 1.04E−04 
                 1.30 
                 6.39E−07 
                 1.83E−06 
               
               
                 MCP-4 
                 CCL13 
                 1.21 
                 4.98E−05 
                 1.94E−04 
                 1.44 
                 2.66E−09 
                 1.77E−08 
               
               
                 RANTES 
                 CCL5 
                 1.19 
                 6.70E−05 
                 2.38E−04 
                 1.34 
                 1.15E−08 
                 5.13E−08 
               
               
                 IL-1b 
                 IL1B 
                 1.22 
                 1.30E−04 
                 4.22E−04 
                 1.43 
                 2.53E−07 
                 8.44E−07 
               
               
                 MCP-2 
                 CCL8 
                 1.19 
                 1.76E−04 
                 5.27E−04 
                 1.50 
                 7.15E−10 
                 5.72E−09 
               
               
                 IL-10 
                 IL10 
                 1.25 
                 2.99E−04 
                 8.34E−04 
                 1.36 
                 1.07E−05 
                 2.53E−05 
               
               
                 I-TAC 
                 CXCL11 
                 1.21 
                 8.60E−04 
                 2.24E−03 
                 1.40 
                 3.03E−05 
                 6.06E−05 
               
               
                 CXCL13 
                 CXCL13 
                 1.31 
                 1.35E−03 
                 3.25E−03 
                 1.68 
                 9.06E−08 
                 3.30E−07 
               
               
                 IP-10 
                 CXCL10 
                 1.28 
                 1.42E−03 
                 3.25E−03 
                 1.64 
                 5.88E−08 
                 2.35E−07 
               
               
                 MCP-3 
                 CCL7 
                 1.43 
                 5.11E−03 
                 1.11E−02 
                 1.57 
                 1.38E−03 
                 2.21E−03 
               
               
                 CCL1 
                 CCL1 
                 1.20 
                 5.73E−03 
                 1.18E−02 
                 1.26 
                 1.57E−03 
                 2.35E−03 
               
               
                 CXCL1 
                 CXCL1 
                 1.10 
                 1.19E−02 
                 2.32E−02 
                 1.22 
                 1.32E−05 
                 2.93E−05 
               
               
                 INF-g 
                 IFNg 
                 1.18 
                 1.32E−02 
                 2.45E−02 
                 1.42 
                 1.05E−05 
                 2.53E−05 
               
               
                 CCL26 
                 CCL26 
                 1.16 
                 1.91E−02 
                 3.39E−02 
                 1.32 
                 1.59E−03 
                 2.35E−03 
               
               
                 MIF 
                 MIF 
                 1.23 
                 2.86E−02 
                 4.85E−02 
                 1.38 
                 5.54E−04 
                 1.01E−03 
               
               
                 IL-16 
                 IL16 
                 1.12 
                 3.15E−02 
                 5.13E−02 
                 1.25 
                 9.01E−05 
                 1.72E−04 
               
               
                 IL-6 
                 IL6 
                 1.19 
                 3.37E−02 
                 5.26E−02 
                 1.33 
                 1.06E−03 
                 1.84E−03 
               
               
                 CXCL6 
                 CXCL6 
                 1.18 
                 4.02E−02 
                 6.03E−02 
                 1.16 
                 6.56E−02 
                 7.96E−02 
               
               
                 TECK 
                 CCL25 
                 1.11 
                 5.67E−02 
                 8.19E−02 
                 1.44 
                 3.77E−07 
                 1.16E−06 
               
               
                 GM-CSF 
                 CSF2 
                 1.22 
                 9.66E−02 
                 1.35E−01 
                 1.30 
                 4.65E−02 
                 5.81E−02 
               
               
                 IL-2 
                 IL2 
                 1.16 
                 1.11E−01 
                 1.49E−01 
                 1.34 
                 1.20E−03 
                 2.00E−03 
               
               
                 MPIF-1 
                 CCL23 
                 1.05 
                 2.48E−01 
                 3.22E−01 
                 1.02 
                 6.91E−01 
                 7.47E−01 
               
               
                 MIP-3b 
                 CCL19 
                 1.11 
                 2.72E−01 
                 3.42E−01 
                 1.25 
                 1.93E−02 
                 2.57E−02 
               
               
                 SDF-1a + b 
                 CXCL12 
                 1.05 
                 3.41E−01 
                 4.15E−01 
                 1.07 
                 2.55E−01 
                 2.92E−01 
               
               
                 CXCL2 
                 CXCL2 
                 1.17 
                 4.06E−01 
                 4.80E−01 
                 1.65 
                 2.85E−03 
                 4.07E−03 
               
               
                 MIG 
                 CXCL9 
                 1.07 
                 4.43E−01 
                 5.08E−01 
                 1.31 
                 5.46E−03 
                 7.54E−03 
               
               
                 CCL11 
                 CCL11 
                 0.99 
                 4.61E−01 
                 5.13E−01 
                 1.00 
                 8.61E−01 
                 9.06E−01 
               
               
                 CXCL5 
                 CXCL5 
                 0.93 
                 5.16E−01 
                 5.59E−01 
                 0.79 
                 3.05E−02 
                 3.94E−02 
               
               
                 MIP-1d (M           
                 CCL15 
                 0.97 
                 5.45E−01 
                 5.74E−01 
                 1.00 
                 9.22E−01 
                 9.22E−01 
               
               
                 SCYB16 
                 CXCL16 
                 1.01 
                 6.77E−01 
                 6.94E−01 
                 1.02 
                 5.44E−01 
                 6.05E−01 
               
               
                 CCL21 
                 CCL21 
                 1.01 
                 8.27E−01 
                 8.27E−01 
                 1.00 
                 8.96E−01 
                 9.19E−01 
               
               
                 IL-4 
                 IL4 
                 NA 
                 NA 
                 NA 
                 1.26 
                 1.62E−01 
                 1.91E−01 
               
               
                 TARC 
                 CCL17 
                 0.76 
                 NA 
                 NA 
                 1.39 
                 NA 
                 NA 
               
               
                 CCL27 
                 CCL27 
                 NA 
                 NA 
                 NA 
                 NA 
                 NA 
                 NA 
               
               
                   
               
               
                             indicates data missing or illegible when filed 
               
             
          
         
       
     
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