Abstract:
The present invention provides purified blood plasma products from fraction II+III containing proteins at concentrations useful for the treatment of various diseases and infections including hepatitis B virus. Methods of manufacture and treatment are also provided. The purified blood plasma products regulate levels of immune cells and their proteins in the organs and peripheral blood of treated subjects. Examples of immune cells and associated proteins regulated by the purified blood plasma products include CD62L levels on T cells, CD4+, CD8+, CD28+, and Foxp3+ T cells, B cells, as well as granulocytes and macrophages.

Description:
CROSS REFERENCE TO RELATED APPLICATIONS 
       [0001]    The present patent application claims priority to and is a §371 national application of Patent Cooperative Treaty (“PCT”) application PCT/US15/32807, filed May 28, 2015, which claims priority to provisional application No. 62/003,664, filed May 28, 2014, which is incorporated by reference in its entirety. This application is also a continuation in part of non-provisional application Ser. No. 14/151,147, filed on Jan. 9, 2014, which is a continuation in part of non-provisional application Ser. No. 13/108,970, filed May 6, 2011, which is a continuation in part of non-provisional patent application Ser. No. 13/064,070, filed Mar. 4, 2011, each of which application is incorporated herein by reference. 
     
    
     FIELD OF THE INVENTION 
       [0002]    The invention relates to the isolation and purification of blood plasma, products derived therefrom, and methods of modifying levels of immune cells and related proteins in peripheral blood and organs of a treated individual. 
       BACKGROUND OF THE INVENTION 
       [0003]    The practice of administering antibodies or antitoxins acquired from exposed or vaccinated individuals or animals to a patient susceptible to the disease in question has been the underlying medical practice involved in passive immunotherapy since the late 1800s. Since the 1940s human albumin and other therapeutic proteins have been extracted from plasma to address specific clinical needs. 
         [0004]    In comparison to most antibiotics, antibody-based therapies that use human antibodies have low toxicity and high specificity. The high specificity means that the antibody targets only the disease-causing microorganism that causes disease without affecting the host&#39;s endogenous organisms, therefore minimizing adverse reactions and the chance of the development of resistant organisms. This also means, however, that more than one antibody preparation may be required to target micro-organisms with high antigenic variation. Combination plasma products containing antibodies specific for a variety of diseases and afflictions, as well as therapies for administering the same, are therefore desired for addressing a range of diseases while minimizing damage to healthy cells. 
         [0005]    The identification of various fractions of human plasma as well as the proteins residing therein and the unique characteristics of those proteins, has resulted in new life saving treatments for a variety of chronic and acute, hereditary and acquired diseases. Improvements in the manufacturing processes that ensure product safety and efficacy, and the identification of specific clinical applications require new advances in the technology. 
         [0006]    Various techniques to remove protein aggregates, such as chromatography, have made some products more tolerable when administered intravenously and the addition of virus removal/inactivation steps has made the products essentially free of lipid and nonlipid enveloped viruses. 
         [0007]    Intravenous immunoglobin (IVIG) is a blood product generally administered intravenously. IVIG is administered to patients with immunodeficiencies and its benefits for secondary ailments related to immunodeficiencies has made it an increasingly appealing first or second line treatment. 
         [0008]    IVIG is manufactured from pooled human plasma and contains white blood cells called lymphocytes. A lymphocyte is any of three types of immune cells including: (1) natural killer cells (NK cells, which function in cell-mediated, cytotoxic innate immunity), (2) T cells (for cell-mediated, cytotoxic adaptive immunity), and (3) B cells (for humoral, antibody-driven adaptive immunity). 
         [0009]    Antibodies are produced by the B-cells and plasma cells after exposure to antigens. They can be either immunoglobin G (IgG), IgA, IgM, IgE, or IgD, but in the case of hyper-immunes, IgG are the antibodies of interest. IgG consists of four polypeptide chains, two pairs of polypeptide chains, two pairs of heavy and light chains in a Y-shaped arrangement. The top ends of the IgG molecule, Fab or antibody binding region, are created from one heavy and one light chain, forming the antigen binding site. This fragment variable (Fv) region contains various amino acid combinations, which makes each antibody unique. Importantly, purified IVIG intravenous hyperimmune products contain human IgG protein, of which at least 96% is IgG containing specific antibodies against the specific antigen. Significantly, since the mid to late 2000s the need for more efficient manufacture of isolated purified IVIG has increased dramatically. Products regulating the percentages of B and T cells to target specific ailments and disease are also desirable. 
       SUMMARY OF THE INVENTION 
       [0010]    The invention relates to isolated purified human immunoglobulin plasma products, methods of their manufacture and their use in treating diseases and infections such as hepatitis B virus. The purified human immunoglobulin plasma products are useful in treating a variety of chronic and acute, hereditary and acquired diseases by regulating the levels of immune cells and their related proteins in the treated subject. 
         [0011]    In embodiments of the invention various purified blood plasma products are used to treat viral infections such as HBV by modifying lymphocyte proliferation in an individual. 
         [0012]    Certain embodiments of the invention include the regulation of B and T cell levels in the peripheral blood and organs of a treated individual through prophylactic or therapeutic administration of purified blood plasma products. 
         [0013]    Other embodiments include the regulation of granulocyte and macrophage levels in the peripheral blood and organs of a treated individual through prophylactic or therapeutic administration of purified blood plasma products. 
         [0014]    In one embodiment of the invention a purified protein complex is obtained by purifying intravenous immunoglobulin G (IVIG) from human plasma fraction II+III paste.  FIG. 73 . In addition to the main component of immunoglobulin, analysis of the protein complex has shown the product to contain the following proteins: 120/E19 IGHV4-31, IGHG1 44 kDa, 191/H18 IGHV4 31, IGHG1 32 kDa, IGHG1 putative uncharacterized protein, DKFZp686G11190, and KH proteins 33-37.  FIG. 75 . The combination of KH proteins 33-37 with a concentration of 30% has been found to very effective against viruses such as H1N1, H5N1, foot and mouth disease, and to stop hepatitis B viral DNA replication. 
         [0015]    In another embodiment of the invention a purified protein complex is obtained by purifying hepatitis B immune globulin (HBIG) from human plasma fraction II+III of donors having high antibody levels of the hepatitis B surface antigen.  FIG. 74 . In addition to immunoglobulin proteins, HBIG contains the protein TF serotransferrin (sequence no. 197/H24). This complex contains KH proteins 22-37 and has been found to be effective in stopping hepatitis B viral DNA replication. 
         [0016]    In yet another embodiment a purified protein complex is formulated to combat the scarcity of the hepatitis B antibody.  FIGS. 77-78 . This purified protein complex is a combination of 80% purified normal immunoglobulin and 20% purified hepatitis B immune globulin containing high levels of hepatitis B antibodies. In this embodiment both of the products have a concentration by ultra filtration of at least 30%. The purified protein complex of this embodiment contains proteins designated as KH22-37 and KH51. Additional information regarding KH designated proteins is included herein. 
         [0017]    In a related embodiment a method of manufacture for a purified protein complex comprises: following manufacturing protocol to separately manufacture normal immunoglobulin and hepatitis B antibody up to the step of obtaining non-sterile final bulk for both products, taking 80% normal immunoglobulin non-sterile final bulk and mixing with 20% hepatitis B antibody non-sterile final bulk, and performing sterile filtration for filling the final product.  FIG. 77 . 
         [0018]    In another embodiment the method of manufacture for a purified protein complex comprises: taking 80% of normal immunoglobulin fraction II+III and 20% hepatitis B antibody fraction II+III, and dissolving the fractions together in a process tank for production of the normal immunoglobulin until the final product is filled.  FIG. 78 . 
         [0019]    Embodiments of the invention include purified protein complexes containing various proteins having unique characteristics useful in treating infection and disease. A “KH” designation has been assigned to certain proteins contained in the purified protein complexes. Those designations, as well as additional information corresponding to those proteins is found in the figures below. 
         [0020]    538 functions have been identified for the 55 KEI proteins, which provide them with unique characteristics for treating a wide range of disease, infection, and other cellular disturbances as expressed in some embodiments of the invention as described. 
         [0000]    
       
         
               
               
               
               
               
             
           
               
                   
               
               
                   
                   
                 Fraction - P 
                   
                   
               
               
                   
                   
                 (process), C 
               
               
                   
                   
                 (component), 
                 Sequence 
               
               
                 Number 
                 GI code 
                 F (function) 
                 name 
                 Sequence desc. 
               
               
                   
               
             
             
               
                 KH 1 
                 21749960 
                 cryopaste 
                 gi|21749960 
                 dock4_humandedicator of 
               
               
                   
                   
                   
                   
                 cytokinesis protein 4 os =  homo   
               
               
                   
                   
                   
                   
                   sapiens  gn = dock4 pe = 1 sv = 3 
               
               
                 gi|21749960 
                 dock4_humandedicator of 
                 F 
                 GO:0005102 
                 receptor binding 
               
               
                   
                 cytokinesis protein 4 os =  homo   
               
               
                   
                   sapiens  gn = dock4 pe = 1 sv = 3 
               
               
                 gi|21749960 
                 dock4_humandedicator of 
                 P 
                 GO:0043547 
                 positive regulation of GTPase 
               
               
                   
                 cytokinesis protein 4 os =  homo   
                   
                   
                 activity 
               
               
                   
                   sapiens  gn = dock4 pe = 1 sv = 3 
               
               
                 gi|21749960 
                 dock4_humandedicator of 
                 P 
                 GO:0016477 
                 cell migration 
               
               
                   
                 cytokinesis protein 4 os =  homo   
               
               
                   
                   sapiens  gn = dock4 pe = 1 sv = 3 
               
               
                 gi|21749960 
                 dock4_humandedicator of 
                 P 
                 GO:0007165 
                 signal transduction 
               
               
                   
                 cytokinesis protein 4 os =  homo   
               
               
                   
                   sapiens  gn = dock4 pe = 1 sv = 3 
               
               
                 gi|21749960 
                 dock4_humandedicator of 
                 P 
                 GO:0006935 
                 chemotaxis 
               
               
                   
                 cytokinesis protein 4 os =  homo   
               
               
                   
                   sapiens  gn = dock4 pe = 1 sv = 3 
               
               
                 gi|21749960 
                 dock4_humandedicator of 
                 C 
                 GO:0005737 
                 cytoplasm 
               
               
                   
                 cytokinesis protein 4 os =  homo   
               
               
                   
                   sapiens  gn = dock4 pe = 1 sv = 3 
               
               
                 gi|21749960 
                 dock4_humandedicator of 
                 F 
                 GO:0005083 
                 small GTPase regulator activity 
               
               
                   
                 cytokinesis protein 4 os =  homo   
               
               
                   
                   sapiens  gn = dock4 pe = 1 sv = 3 
               
               
                 gi|21749960 
                 dock4_humandedicator of 
                 F 
                 GO:0019904 
                 protein domain specific binding 
               
               
                   
                 cytokinesis protein 4 os =  homo   
               
               
                   
                   sapiens  gn = dock4 pe = 1 sv = 3 
               
               
                 gi|21749960 
                 dock4_humandedicator of 
                 P 
                 GO:0048583 
                 regulation of response to 
               
               
                   
                 cytokinesis protein 4 os =  homo   
                   
                   
                 stimulus 
               
               
                   
                   sapiens  gn = dock4 pe = 1 sv = 3 
               
               
                 gi|21749960 
                 dock4_humandedicator of 
                 F 
                 GO:0005096 
                 GTPase activator activity 
               
               
                   
                 cytokinesis protein 4 os =  homo   
               
               
                   
                   sapiens  gn = dock4 pe = 1 sv = 3 
               
               
                 gi|21749960 
                 dock4_humandedicator of 
                 F 
                 GO:0051020 
                 GTPase binding 
               
               
                   
                 cytokinesis protein 4 os =  homo   
               
               
                   
                   sapiens  gn = dock4 pe = 1 sv = 3 
               
               
                 gi|21749960 
                 dock4_humandedicator of 
                 C 
                 GO:0016020 
                 membrane 
               
               
                   
                 cytokinesis protein 4 os =  homo   
               
               
                   
                   sapiens  gn = dock4 pe = 1 sv = 3 
               
               
                 KH 2 
                 215415640 
                 cryopaste 
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
               
               
                   
                   
                   
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                   
                   
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0070508 
                 cholesterol import 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 C 
                 GO:0030139 
                 endocytic vesicle 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0050728 
                 negative regulation of 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 inflammatory response 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0033344 
                 cholesterol efflux 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0034115 
                 negative regulation of 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 heterotypic cell-cell adhesion 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0018206 
                 peptidyl-methionine 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 modification 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0042157 
                 lipoprotein metabolic process 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0043691 
                 reverse cholesterol transport 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 F 
                 GO:0005543 
                 phospholipid binding 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0002740 
                 negative regulation of cytokine 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 secretion involved in immune 
               
               
                   
                 sv = 1 
                   
                   
                 response 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0008203 
                 cholesterol metabolic process 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0050713 
                 negative regulation of 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 interleukin-1 beta secretion 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0018158 
                 protein oxidation 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0006656 
                 phosphatidylcholine biosynthetic 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 process 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 F 
                 GO:0001540 
                 beta-amyloid binding 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 F 
                 GO:0060228 
                 phosphatidylcholine-sterol O- 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 acyltransferase activator activity 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0042632 
                 cholesterol homeostasis 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 F 
                 GO:0015485 
                 cholesterol binding 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0042060 
                 wound healing 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 F 
                 GO:0034191 
                 apolipoprotein A-I receptor 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 binding 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 F 
                 GO:0042802 
                 identical protein binding 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0010903 
                 negative regulation of very-low- 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 density lipoprotein particle 
               
               
                   
                 sv = 1 
                   
                   
                 remodeling 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0010804 
                 negative regulation of tumor 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 necrosis factor-mediated 
               
               
                   
                 sv = 1 
                   
                   
                 signaling pathway 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0034380 
                 high-density lipoprotein particle 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 assembly 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0007186 
                 G-protein coupled receptor 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 signaling pathway 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0050821 
                 protein stabilization 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 C 
                 GO:0034361 
                 very-low-density lipoprotein 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 particle 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0032488 
                 Cdc42 protein signal 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 transduction 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0060354 
                 negative regulation of cell 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 adhesion molecule production 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0055091 
                 phospholipid homeostasis 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0010873 
                 positive regulation of cholesterol 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 esterification 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 F 
                 GO:0017127 
                 cholesterol transporter activity 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 F 
                 GO:0019899 
                 enzyme binding 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 F 
                 GO:0070653 
                 high-density lipoprotein particle 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 receptor binding 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0070328 
                 triglyceride homeostasis 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 C 
                 GO:0034366 
                 spherical high-density 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 lipoprotein particle 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0033700 
                 phospholipid efflux 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415640 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0051345 
                 positive regulation of hydrolase 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 activity 
               
               
                   
                 sv = 1 
               
               
                 KH 3 
                 215415638 
                 Fr III 
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
               
               
                   
                   
                   
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                   
                   
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0070508 
                 cholesterol import 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 C 
                 GO:0030139 
                 endocytic vesicle 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0050728 
                 negative regulation of 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 inflammatory response 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0033344 
                 cholesterol efflux 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0034115 
                 negative regulation of 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 heterotypic cell-cell adhesion 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0018206 
                 peptidyl-methionine 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 modification 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0042157 
                 lipoprotein metabolic process 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0043691 
                 reverse cholesterol transport 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 F 
                 GO:0005543 
                 phospholipid binding 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0002740 
                 negative regulation of cytokine 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 secretion involved in immune 
               
               
                   
                 sv = 1 
                   
                   
                 response 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0008203 
                 cholesterol metabolic process 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0050713 
                 negative regulation of 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 interleukin-1 beta secretion 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0018158 
                 protein oxidation 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0006656 
                 phosphatidylcholine biosynthetic 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 process 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 F 
                 GO:0001540 
                 beta-amyloid binding 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 F 
                 GO:0060228 
                 phosphatidylcholine-sterol O- 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 acyltransferase activator activity 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0042632 
                 cholesterol homeostasis 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 F 
                 GO:0015485 
                 cholesterol binding 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0042060 
                 wound healing 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 F 
                 GO:0034191 
                 apolipoprotein A-I receptor 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 binding 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 F 
                 GO:0042802 
                 identical protein binding 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0010903 
                 negative regulation of very-low- 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 density lipoprotein particle 
               
               
                   
                 sv = 1 
                   
                   
                 remodeling 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0010804 
                 negative regulation of tumor 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 necrosis factor-mediated 
               
               
                   
                 sv = 1 
                   
                   
                 signaling pathway 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0034380 
                 high-density lipoprotein particle 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 assembly 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0007186 
                 G-protein coupled receptor 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 signaling pathway 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0050821 
                 protein stabilization 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 C 
                 GO:0034361 
                 very-low-density lipoprotein 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 particle 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0032488 
                 Cdc42 protein signal 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 transduction 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0060354 
                 negative regulation of cell 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 adhesion molecule production 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0055091 
                 phospholipid homeostasis 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0010873 
                 positive regulation of cholesterol 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 esterification 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 F 
                 GO:0017127 
                 cholesterol transporter activity 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 F 
                 GO:0019899 
                 enzyme binding 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 F 
                 GO:0070653 
                 high-density lipoprotein particle 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 receptor binding 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0070328 
                 triglyceride homeostasis 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 C 
                 GO:0034366 
                 spherical high-density 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 lipoprotein particle 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0033700 
                 phospholipid efflux 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 gi|215415638 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0051345 
                 positive regulation of hydrolase 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 activity 
               
               
                   
                 sv = 1 
               
               
                 KH 4 
                 40044478 
                 Fr III 
               
               
                 KH 5 
                 194383496 
                 Fr III 
                 gi|194383496 
                 thrb_humanprothrombin 
               
               
                   
                   
                   
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                   
                   
                   
                 sv = 2 
               
               
                 gi|194383496 
                 thrb_humanprothrombin 
                 P 
                 GO:0032879 
                 regulation of localization 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194383496 
                 thrb_humanprothrombin 
                 P 
                 GO:0048468 
                 cell development 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194383496 
                 thrb_humanprothrombin 
                 P 
                 GO:2000026 
                 regulation of multicellular 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
                   
                   
                 organismal development 
               
               
                   
                 sv = 2 
               
               
                 gi|194383496 
                 thrb_humanprothrombin 
                 P 
                 GO:0010557 
                 positive regulation of 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
                   
                   
                 macromolecule biosynthetic 
               
               
                   
                 sv = 2 
                   
                   
                 process 
               
               
                 gi|194383496 
                 thrb_humanprothrombin 
                 P 
                 GO:0030194 
                 positive regulation of blood 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
                   
                   
                 coagulation 
               
               
                   
                 sv = 2 
               
               
                 gi|194383496 
                 thrb_humanprothrombin 
                 F 
                 GO:0005102 
                 receptor binding 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194383496 
                 thrb_humanprothrombin 
                 P 
                 GO:0009967 
                 positive regulation of signal 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
                   
                   
                 transduction 
               
               
                   
                 sv = 2 
               
               
                 gi|194383496 
                 thrb_humanprothrombin 
                 C 
                 GO:0005615 
                 extracellular space 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194383496 
                 thrb_humanprothrombin 
                 P 
                 GO:0030168 
                 platelet activation 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194383496 
                 thrb_humanprothrombin 
                 F 
                 GO:0008236 
                 serine-type peptidase activity 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194383496 
                 thrb_humanprothrombin 
                 P 
                 GO:0016477 
                 cell migration 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194383496 
                 thrb_humanprothrombin 
                 P 
                 GO:0006508 
                 proteolysis 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194383496 
                 thrb_humanprothrombin 
                 P 
                 GO:0001934 
                 positive regulation of protein 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
                   
                   
                 phosphorylation 
               
               
                   
                 sv = 2 
               
               
                 gi|194383496 
                 thrb_humanprothrombin 
                 P 
                 GO:0007166 
                 cell surface receptor signaling 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
                   
                   
                 pathway 
               
               
                   
                 sv = 2 
               
               
                 gi|194383496 
                 thrb_humanprothrombin 
                 P 
                 GO:0048523 
                 negative regulation of cellular 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
                   
                   
                 process 
               
               
                   
                 sv = 2 
               
               
                 gi|194383496 
                 thrb_humanprothrombin 
                 P 
                 GO:0006810 
                 transport 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194383496 
                 thrb_humanprothrombin 
                 P 
                 GO:0042730 
                 fibrinolysis 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194383496 
                 thrb_humanprothrombin 
                 C 
                 GO:0005622 
                 intracellular 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194383496 
                 thrb_humanprothrombin 
                 P 
                 GO:0048731 
                 system development 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194383496 
                 thrb_humanprothrombin 
                 C 
                 GO:0016020 
                 membrane 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194383496 
                 thrb_humanprothrombin 
                 P 
                 GO:0051480 
                 cytosolic calcium ion 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
                   
                   
                 homeostasis 
               
               
                   
                 sv = 2 
               
               
                 KH 6 
                 28071026 
                 Fr III 
                 gi|28071026 
                 ighm_humanig mu chain c region 
               
               
                   
                   
                   
                   
                 os =  homo sapiens  gn = ighm_pe = 1 
               
               
                   
                   
                   
                   
                 sv = 3 
               
               
                 gi|28071026 
                 ighm_humanig mu chain c region 
                 F 
                 GO:0005488 
                 binding 
               
               
                   
                 os =  homo sapiens  gn = ighm_pe = 1 
               
               
                   
                 sv = 3 
               
               
                 gi|28071026 
                 ighm_humanig mu chain c region 
                 C 
                 GO:0044464 
                 cell part 
               
               
                   
                 os =  homo sapiens  gn = ighm_pe = 1 
               
               
                   
                 sv = 3 
               
               
                 gi|28071026 
                 ighm_humanig mu chain c region 
                 C 
                 GO:0016020 
                 membrane 
               
               
                   
                 os =  homo sapiens  gn = ighm_pe = 1 
               
               
                   
                 sv = 3 
               
               
                 gi|28071026 
                 ighm_humanig mu chain c region 
                 P 
                 GO:0006955 
                 immune response 
               
               
                   
                 os =  homo sapiens  gn = ighm_pe = 1 
               
               
                   
                 sv = 3 
               
               
                 KH 7 
                 300621695 
                 Fr III 
                 gi|300621695 
                 ighm_humanig mu chain c region 
               
               
                   
                   
                   
                   
                 os =  homo sapiens  gn = ighm_pe = 1 
               
               
                   
                   
                   
                   
                 sv = 3 
               
               
                 gi|300621695 
                 ighm_humanig mu chain c region 
                 P 
                 GO:0006955 
                 immune response 
               
               
                   
                 os =  homo sapiens  gn = ighm_pe = 1 
               
               
                   
                 sv = 3 
               
               
                 KH 8 
                 1335098 
                 Fr III 
                 gi|1335098 
                 hemo_humanhemopexin 
               
               
                   
                   
                   
                   
                 os =  homo sapiens  gn = hpx pe = 1 
               
               
                   
                   
                   
                   
                 sv = 2 
               
               
                 gi|1335098 
                 hemo_humanhemopexin 
                 P 
                 GO:0008152 
                 metabolic process 
               
               
                   
                 os =  homo sapiens  gn = hpx pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|1335098 
                 hemo_humanhemopexin 
                 P 
                 GO:0051179 
                 localization 
               
               
                   
                 os =  homo sapiens  gn = hpx pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|1335098 
                 hemo_humanhemopexin 
                 C 
                 GO:0005615 
                 extracellular space 
               
               
                   
                 os =  homo sapiens  gn = hpx pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|1335098 
                 hemo_humanhemopexin 
                 F 
                 GO:0005515 
                 protein binding 
               
               
                   
                 os =  homo sapiens  gn = hpx pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|1335098 
                 hemo_humanhemopexin 
                 P 
                 GO:0048522 
                 positive regulation of cellular 
               
               
                   
                 os =  homo sapiens  gn = hpx pe = 1 
                   
                   
                 process 
               
               
                   
                 sv = 2 
               
               
                 gi|1335098 
                 hemo_humanhemopexin 
                 P 
                 GO:0050896 
                 response to stimulus 
               
               
                   
                 os =  homo sapiens  gn = hpx pe = 1 
               
               
                   
                 sv = 2 
               
               
                 KH 9 
                 10434804 
                 Fr III 
                 gi|10434804 
                 mthsd_humanmethenyltetra- 
               
               
                   
                   
                   
                   
                 hydrofolate synthase domain- 
               
               
                   
                   
                   
                   
                 containing protein os =  homo   
               
               
                   
                   
                   
                   
                   sapiens  gn = mthfsd pe = 1 sv = 2 
               
               
                 gi|10434804 
                 mthsd_humanmethenyltetra- 
                 F 
                 GO:0005524 
                 ATP binding 
               
               
                   
                 hydrofolate synthase domain- 
               
               
                   
                 containing protein os =  homo   
               
               
                   
                   sapiens  gn = mthfsd pe = 1 sv = 2 
               
               
                 gi|10434804 
                 mthsd_humanmethenyltetra- 
                 P 
                 GO:0009396 
                 folic acid-containing compound 
               
               
                   
                 hydrofolate synthase domain- 
                   
                   
                 biosynthetic process 
               
               
                   
                 containing protein os =  homo   
               
               
                   
                   sapiens  gn = mthfsd pe = 1 sv = 2 
               
               
                 gi|10434804 
                 mthsd_humanmethenyltetra- 
                 F 
                 GO:0030272 
                 5-formyltetrahydrofolate cyclo- 
               
               
                   
                 hydrofolate synthase domain- 
                   
                   
                 ligase activity 
               
               
                   
                 containing protein os =  homo   
               
               
                   
                   sapiens  gn = mthfsd pe = 1 sv = 2 
               
               
                 KH 10 
                 221044726 
                 Fr III 
                 gi|221044726 
                 hemo_humanhemopexin 
               
               
                   
                   
                   
                   
                 os =  homo sapiens  gn = hpx pe = 1 
               
               
                   
                   
                   
                   
                 sv = 2 
               
               
                 gi|221044726 
                 hemo_humanhemopexin 
                 F 
                 GO:0005515 
                 protein binding 
               
               
                   
                 os =  homo sapiens  gn = hpx pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|221044726 
                 hemo_humanhemopexin 
                 C 
                 GO:0005615 
                 extracellular space 
               
               
                   
                 os =  homo sapiens  gn = hpx pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|221044726 
                 hemo_humanhemopexin 
                 P 
                 GO:0009987 
                 cellular process 
               
               
                   
                 os =  homo sapiens  gn = hpx pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|221044726 
                 hemo_humanhemopexin 
                 P 
                 GO:0065007 
                 biological regulation 
               
               
                   
                 os =  homo sapiens  gn = hpx pe = 1 
               
               
                   
                 sv = 2 
               
               
                 KH 11 
                 215415638 
                 PCC 
                 same as 
               
               
                   
                   
                   
                 KH 3 
               
               
                 KH 12 
                 189066554 
                 PCC 
                 gi|189066554 
                 thrb_humanprothrombin 
               
               
                   
                   
                   
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                   
                   
                   
                 sv = 2 
               
               
                 gi|189066554 
                 thrb_humanprothrombin 
                 C 
                 GO:0044446 
                 intracellular organelle part 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|189066554 
                 thrb_humanprothrombin 
                 P 
                 GO:0048712 
                 negative regulation of astrocyte 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
                   
                   
                 differentiation 
               
               
                   
                 sv = 2 
               
               
                 gi|189066554 
                 thrb_humanprothrombin 
                 C 
                 GO:0043233 
                 organelle lumen 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|189066554 
                 thrb_humanprothrombin 
                 P 
                 GO:0030194 
                 positive regulation of blood 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
                   
                   
                 coagulation 
               
               
                   
                 sv = 2 
               
               
                 gi|189066554 
                 thrb_humanprothrombin 
                 F 
                 GO:0005102 
                 receptor binding 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|189066554 
                 thrb_humanprothrombin 
                 P 
                 GO:2000379 
                 positive regulation of reactive 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
                   
                   
                 oxygen species metabolic 
               
               
                   
                 sv = 2 
                   
                   
                 process 
               
               
                 gi|189066554 
                 thrb_humanprothrombin 
                 P 
                 GO:0045861 
                 negative regulation of proteolysis 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|189066554 
                 thrb_humanprothrombin 
                 C 
                 GO:0005615 
                 extracellular space 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|189066554 
                 thrb_humanprothrombin 
                 P 
                 GO:0030168 
                 platelet activation 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|189066554 
                 thrb_humanprothrombin 
                 P 
                 GO:1900738 
                 positive regulation of 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
                   
                   
                 phospholipase C-activating G- 
               
               
                   
                 sv = 2 
                   
                   
                 protein coupled receptor 
               
               
                   
                   
                   
                   
                 signaling pathway 
               
               
                 gi|189066554 
                 thrb_humanprothrombin 
                 P 
                 GO:0016477 
                 cell migration 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|189066554 
                 thrb_humanprothrombin 
                 C 
                 GO:0043231 
                 intracellular membrane-bounded 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
                   
                   
                 organelle 
               
               
                   
                 sv = 2 
               
               
                 gi|189066554 
                 thrb_humanprothrombin 
                 P 
                 GO:0001934 
                 positive regulation of protein 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
                   
                   
                 phosphorylation 
               
               
                   
                 sv = 2 
               
               
                 gi|189066554 
                 thrb_humanprothrombin 
                 C 
                 GO:0005886 
                 plasma membrane 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|189066554 
                 thrb_humanprothrombin 
                 F 
                 GO:0070053 
                 thrombospondin receptor activity 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|189066554 
                 thrb_humanprothrombin 
                 P 
                 GO:0051281 
                 positive regulation of release of 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
                   
                   
                 sequestered calcium ion into 
               
               
                   
                 sv = 2 
                   
                   
                 cytosol 
               
               
                 gi|189066554 
                 thrb_humanprothrombin 
                 F 
                 GO:0004252 
                 serine-type endopeptidase 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
                   
                   
                 activity 
               
               
                   
                 sv = 2 
               
               
                 gi|189066554 
                 thrb_humanprothrombin 
                 P 
                 GO:0042730 
                 fibrinolysis 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|189066554 
                 thrb_humanprothrombin 
                 C 
                 GO:0044444 
                 cytoplasmic part 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|189066554 
                 thrb_humanprothrombin 
                 P 
                 GO:0032967 
                 positive regulation of collagen 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
                   
                   
                 biosynthetic process 
               
               
                   
                 sv = 2 
               
               
                 KH 13 
                 194391084 
                 PCC 
                 gi|194391084 
                 kng1_humankininogen-1 
               
               
                   
                   
                   
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                   
                   
                   
                 sv = 2 
               
               
                 gi|194391084 
                 kng1_humankininogen-1 
                 F 
                 GO:0005515 
                 protein binding 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194391084 
                 kng1_humankininogen-1 
                 P 
                 GO:0055065 
                 metal ion homeostasis 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194391084 
                 kng1_humankininogen-1 
                 P 
                 GO:0051241 
                 negative regulation of 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
                   
                   
                 multicellular organismal process 
               
               
                   
                 sv = 2 
               
               
                 gi|194391084 
                 kng1_humankininogen-1 
                 P 
                 GO:0007596 
                 blood coagulation 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194391084 
                 kng1_humankininogen-1 
                 C 
                 GO:0043229 
                 intracellular organelle 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194391084 
                 kng1_humankininogen-1 
                 P 
                 GO:0048523 
                 negative regulation of cellular 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
                   
                   
                 process 
               
               
                   
                 sv = 2 
               
               
                 gi|194391084 
                 kng1_humankininogen-1 
                 P 
                 GO:0008152 
                 metabolic process 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194391084 
                 kng1_humankininogen-1 
                 P 
                 GO:0003008 
                 system process 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 KH 14 
                 158255114 
                 PCC 
                 gi|158255114 
                 kng1_humankininogen-1 
               
               
                   
                   
                   
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                   
                   
                   
                 sv = 2 
               
               
                 gi|158255114 
                 kng1_humankininogen-1 
                 F 
                 GO:0005515 
                 protein binding 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|158255114 
                 kng1_humankininogen-1 
                 P 
                 GO:0055065 
                 metal ion homeostasis 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|158255114 
                 kng1_humankininogen-1 
                 P 
                 GO:0051241 
                 negative regulation of 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
                   
                   
                 multicellular organismal process 
               
               
                   
                 sv = 2 
               
               
                 gi|158255114 
                 kng1_humankininogen-1 
                 P 
                 GO:0007596 
                 blood coagulation 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|158255114 
                 kng1_humankininogen-1 
                 C 
                 GO:0043229 
                 intracellular organelle 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|158255114 
                 kng1_humankininogen-1 
                 P 
                 GO:0048523 
                 negative regulation of cellular 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
                   
                   
                 process 
               
               
                   
                 sv = 2 
               
               
                 gi|158255114 
                 kng1_humankininogen-1 
                 P 
                 GO:0008152 
                 metabolic process 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|158255114 
                 kng1_humankininogen-1 
                 P 
                 GO:0003008 
                 system process 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 KH 15 
                 213506121 
                 PCC 
                 gi|213506121 
                 kng1_humankininogen-1 
               
               
                   
                   
                   
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                   
                   
                   
                 sv = 2 
               
               
                 gi|213506121 
                 kng1_humankininogen-1 
                 F 
                 GO:0005515 
                 protein binding 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|213506121 
                 kng1_humankininogen-1 
                 P 
                 GO:0055065 
                 metal ion homeostasis 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|213506121 
                 kng1_humankininogen-1 
                 P 
                 GO:0051241 
                 negative regulation of 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
                   
                   
                 multicellular organismal process 
               
               
                   
                 sv = 2 
               
               
                 gi|213506121 
                 kng1_humankininogen-1 
                 P 
                 GO:0007596 
                 blood coagulation 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|213506121 
                 kng1_humankininogen-1 
                 C 
                 GO:0043229 
                 intracellular organelle 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|213506121 
                 kng1_humankininogen-1 
                 P 
                 GO:0048523 
                 negative regulation of cellular 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
                   
                   
                 process 
               
               
                   
                 sv = 2 
               
               
                 gi|213506121 
                 kng1_humankininogen-1 
                 P 
                 GO:0008152 
                 metabolic process 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|213506121 
                 kng1_humankininogen-1 
                 P 
                 GO:0003008 
                 system process 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 KH 16 
                 213506103 
                 PCC 
                 gi|213506103 
                 kng1_humankininogen-1 
               
               
                   
                   
                   
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                   
                   
                   
                 sv = 2 
               
               
                 gi|213506103 
                 kng1_humankininogen-1 
                 F 
                 GO:0005515 
                 protein binding 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|213506103 
                 kng1_humankininogen-1 
                 P 
                 GO:0055065 
                 metal ion homeostasis 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|213506103 
                 kng1_humankininogen-1 
                 P 
                 GO:0051241 
                 negative regulation of 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
                   
                   
                 multicellular organismal process 
               
               
                   
                 sv = 2 
               
               
                 gi|213506103 
                 kng1_humankininogen-1 
                 P 
                 GO:0007596 
                 blood coagulation 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|213506103 
                 kng1_humankininogen-1 
                 C 
                 GO:0043229 
                 intracellular organelle 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|213506103 
                 kng1_humankininogen-1 
                 P 
                 GO:0048523 
                 negative regulation of cellular 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
                   
                   
                 process 
               
               
                   
                 sv = 2 
               
               
                 gi|213506103 
                 kng1_humankininogen-1 
                 P 
                 GO:0008152 
                 metabolic process 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|213506103 
                 kng1_humankininogen-1 
                 P 
                 GO:0003008 
                 system process 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 KH 17 
                 194376310 
                 PCC 
                 gi|194376310 
                 cytoplasmic 1 os =  homo    sapiens   
               
               
                   
                   
                   
                   
                 gn = actb pe = 1 sv = 1 
               
               
                 gi|194376310 
                 cytoplasmic 1 os =  homo    sapiens   
                 P 
                 GO:0009888 
                 tissue development 
               
               
                   
                 gn = actb pe = 1 sv = 1 
               
               
                 gi|194376310 
                 cytoplasmic 1 os =  homo    sapiens   
                 P 
                 GO:0030048 
                 actin filament-based movement 
               
               
                   
                 gn = actb pe = 1 sv = 1 
               
               
                 gi|194376310 
                 cytoplasmic 1 os =  homo    sapiens   
                 P 
                 GO:0003012 
                 muscle system process 
               
               
                   
                 gn = actb pe = 1 sv = 1 
               
               
                 gi|194376310 
                 cytoplasmic 1 os =  homo    sapiens   
                 C 
                 GO:0030017 
                 sarcomere 
               
               
                   
                 gn = actb pe = 1 sv = 1 
               
               
                 gi|194376310 
                 cytoplasmic 1 os =  homo    sapiens   
                 P 
                 GO:0030239 
                 myofibril assembly 
               
               
                   
                 gn = actb pe = 1 sv = 1 
               
               
                 gi|194376310 
                 cytoplasmic 1 os =  homo    sapiens   
                 P 
                 GO:0044238 
                 primary metabolic process 
               
               
                   
                 gn = actb pe = 1 sv = 1 
               
               
                 gi|194376310 
                 cytoplasmic 1 os =  homo    sapiens   
                 C 
                 GO:0005884 
                 actin filament 
               
               
                   
                 gn = actb pe = 1 sv = 1 
               
               
                 gi|194376310 
                 cytoplasmic 1 os =  homo    sapiens   
                 P 
                 GO:0072358 
                 cardiovascular system 
               
               
                   
                 gn = actb pe = 1 sv = 1 
                   
                   
                 development 
               
               
                 gi|194376310 
                 cytoplasmic 1 os =  homo    sapiens   
                 P 
                 GO:0044237 
                 cellular metabolic process 
               
               
                   
                 gn = actb pe = 1 sv = 1 
               
               
                 gi|194376310 
                 cytoplasmic 1 os =  homo    sapiens   
                 P 
                 GO:0048513 
                 organ development 
               
               
                   
                 gn = actb pe = 1 sv = 1 
               
               
                 gi|194376310 
                 cytoplasmic 1 os =  homo    sapiens   
                 F 
                 GO:0005515 
                 protein binding 
               
               
                   
                 gn = actb pe = 1 sv = 1 
               
               
                 gi|194376310 
                 cytoplasmic 1 os =  homo    sapiens   
                 P 
                 GO:0042221 
                 response to chemical stimulus 
               
               
                   
                 gn = actb pe = 1 sv = 1 
               
               
                 gi|194376310 
                 cytoplasmic 1 os =  homo    sapiens   
                 P 
                 GO:0008015 
                 blood circulation 
               
               
                   
                 gn = actb pe = 1 sv = 1 
               
               
                 KH 18 
                 194388064 
                 PCC 
                 gi|194388064 
                 cytoplasmic 2 os =  homo    sapiens   
               
               
                   
                   
                   
                   
                 gn = actg1 pe = 1 sv = 1 
               
               
                 gi|194388064 
                 cytoplasmic 2 os =  homo    sapiens   
                 P 
                 GO:0009888 
                 tissue development 
               
               
                   
                 gn = actg1 pe = 1 sv = 1 
               
               
                 gi|194388064 
                 cytoplasmic 2 os =  homo    sapiens   
                 P 
                 GO:0030048 
                 actin filament-based movement 
               
               
                   
                 gn = actg1 pe = 1 sv = 1 
               
               
                 gi|194388064 
                 cytoplasmic 2 os =  homo    sapiens   
                 P 
                 GO:0003012 
                 muscle system process 
               
               
                   
                 gn = actg1 pe = 1 sv = 1 
               
               
                 gi|194388064 
                 cytoplasmic 2 os =  homo    sapiens   
                 C 
                 GO:0030017 
                 sarcomere 
               
               
                   
                 gn = actg1 pe = 1 sv = 1 
               
               
                 gi|194388064 
                 cytoplasmic 2 os =  homo    sapiens   
                 P 
                 GO:0030239 
                 myofibril assembly 
               
               
                   
                 gn = actg1 pe = 1 sv = 1 
               
               
                 gi|194388064 
                 cytoplasmic 2 os =  homo    sapiens   
                 P 
                 GO:0044238 
                 primary metabolic process 
               
               
                   
                 gn = actg1 pe = 1 sv = 1 
               
               
                 gi|194388064 
                 cytoplasmic 2 os =  homo    sapiens   
                 C 
                 GO:0005884 
                 actin filament 
               
               
                   
                 gn = actg1 pe = 1 sv = 1 
               
               
                 gi|194388064 
                 cytoplasmic 2 os =  homo    sapiens   
                 P 
                 GO:0072358 
                 cardiovascular system 
               
               
                   
                 gn = actg1 pe = 1 sv = 1 
                   
                   
                 development 
               
               
                 gi|194388064 
                 cytoplasmic 2 os =  homo    sapiens   
                 P 
                 GO:0044237 
                 cellular metabolic process 
               
               
                   
                 gn = actg1 pe = 1 sv = 1 
               
               
                 gi|194388064 
                 cytoplasmic 2 os =  homo    sapiens   
                 P 
                 GO:0048513 
                 organ development 
               
               
                   
                 gn = actg1 pe = 1 sv = 1 
               
               
                 gi|194388064 
                 cytoplasmic 2 os =  homo    sapiens   
                 P 
                 GO:0042221 
                 response to chemical stimulus 
               
               
                   
                 gn = actg1 pe = 1 sv = 1 
               
               
                 gi|194388064 
                 cytoplasmic 2 os =  homo    sapiens   
                 F 
                 GO:0008092 
                 cytoskeletal protein binding 
               
               
                   
                 gn = actg1 pe = 1 sv = 1 
               
               
                 gi|194388064 
                 cytoplasmic 2 os =  homo    sapiens   
                 P 
                 GO:0065008 
                 regulation of biological quality 
               
               
                   
                 gn = actg1 pe = 1 sv = 1 
               
               
                 gi|194388064 
                 cytoplasmic 2 os =  homo    sapiens   
                 C 
                 GO:0044451 
                 nucleoplasm part 
               
               
                   
                 gn = actg1 pe = 1 sv = 1 
               
               
                 gi|194388064 
                 cytoplasmic 2 os =  homo    sapiens   
                 P 
                 GO:0008015 
                 blood circulation 
               
               
                   
                 gn = actg1 pe = 1 sv = 1 
               
               
                 gi|194388064 
                 cytoplasmic 2 os =  homo    sapiens   
                 F 
                 GO:0019899 
                 enzyme binding 
               
               
                   
                 gn = actg1 pe = 1 sv = 1 
               
               
                 gi|194391084 
                 kng1_humankininogen-1 
                 F 
                 GO:0005515 
                 protein binding 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194391084 
                 kng1_humankininogen-1 
                 P 
                 GO:0055065 
                 metal ion homeostasis 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194391084 
                 kng1_humankininogen-1 
                 P 
                 GO:0051241 
                 negative regulation of 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
                   
                   
                 multicellular organismal process 
               
               
                   
                 sv = 2 
               
               
                 gi|194391084 
                 kng1_humankininogen-1 
                 P 
                 GO:0007596 
                 blood coagulation 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194391084 
                 kng1_humankininogen-1 
                 C 
                 GO:0043229 
                 intracellular organelle 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194391084 
                 kng1_humankininogen-1 
                 P 
                 GO:0048523 
                 negative regulation of cellular 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
                   
                   
                 process 
               
               
                   
                 sv = 2 
               
               
                 gi|194391084 
                 kng1_humankininogen-1 
                 P 
                 GO:0008152 
                 metabolic process 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194391084 
                 kng1_humankininogen-1 
                 P 
                 GO:0003008 
                 system process 
               
               
                   
                 os =  homo sapiens  gn = kng1 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 KH 19 
                 IPI00964149 
                 PCC 
                 IPI00964149 
                 pacrl_humanpacrg-like protein 
               
               
                   
                   
                   
                   
                 os =  homo sapiens  gn = pacrgl 
               
               
                   
                   
                   
                   
                 pe = 1 sv = 2 
               
               
                 KH 20 
                 IPI00966721 
                 PCC 
                 IPI00966721 
                 ce028_humantransmembrane 
               
               
                   
                   
                   
                   
                 protein c5orf28 os =  homo sapiens   
               
               
                   
                   
                   
                   
                 gn = c5orf28 pe = 2 sv = 1 
               
               
                 IPI00966721 
                 ce028_humantransmembrane 
                 C 
                 GO:0016021 
                 integral to membrane 
               
               
                   
                 protein c5orf28 os =  homo sapiens   
               
               
                   
                 gn = c5orf28 pe = 2 sv = 1 
               
               
                 KH 21 
                 IPI00966826 
                 FrIV 
                 IPI00966826 
                 pds5a_humansister chromatid 
               
               
                   
                   
                   
                   
                 cohesion protein pds5 homolog a 
               
               
                   
                   
                   
                   
                 os =  homo sapiens  gn = pds5a pe = 1 
               
               
                   
                   
                   
                   
                 sv = 1 
               
               
                 IPI00966826 
                 pds5a_humansister chromatid 
                 P 
                 GO:0008156 
                 negative regulation of DNA 
               
               
                   
                 cohesion protein pds5 homolog a 
                   
                   
                 replication 
               
               
                   
                 os =  homo sapiens  gn = pds5a pe = 1 
               
               
                   
                 sv = 1 
               
               
                 IPI00966826 
                 pds5a_humansister chromatid 
                 C 
                 GO:0005730 
                 nucleolus 
               
               
                   
                 cohesion protein pds5 homolog a 
               
               
                   
                 os =  homo sapiens  gn = pds5a pe = 1 
               
               
                   
                 sv = 1 
               
               
                 IPI00966826 
                 pds5a_humansister chromatid 
                 C 
                 GO:0000785 
                 chromatin 
               
               
                   
                 cohesion protein pds5 homolog a 
               
               
                   
                 os =  homo sapiens  gn = pds5a pe = 1 
               
               
                   
                 sv = 1 
               
               
                 IPI00966826 
                 pds5a_humansister chromatid 
                 F 
                 GO:0005515 
                 protein binding 
               
               
                   
                 cohesion protein pds5 homolog a 
               
               
                   
                 os =  homo sapiens  gn = pds5a pe = 1 
               
               
                   
                 sv = 1 
               
               
                 IPI00966826 
                 pds5a_humansister chromatid 
                 P 
                 GO:0008283 
                 cell proliferation 
               
               
                   
                 cohesion protein pds5 homolog a 
               
               
                   
                 os =  homo sapiens  gn = pds5a pe = 1 
               
               
                   
                 sv = 1 
               
               
                 IPI00966826 
                 pds5a_humansister chromatid 
                 C 
                 GO:0005886 
                 plasma membrane 
               
               
                   
                 cohesion protein pds5 homolog a 
               
               
                   
                 os =  homo sapiens  gn = pds5a pe = 1 
               
               
                   
                 sv = 1 
               
               
                 KH 22 
                 IPI00760788 
                 FrIV 
                 IPI00760788 
                 klh22_humankelch-like protein 
               
               
                   
                   
                   
                   
                 22 os =  homo sapiens  gn = klhl22 
               
               
                   
                   
                   
                   
                 pe = 1 sv = 2 
               
               
                 IPI00760788 
                 klh22_humankelch-like protein 
                 P 
                 GO:0051301 
                 cell division 
               
               
                   
                 22 os =  homo sapiens  gn = klhl22 
               
               
                   
                 pe = 1 sv = 2 
               
               
                 IPI00760788 
                 klh22_humankelch-like protein 
                 C 
                 GO:0031463 
                 Cul3-RING ubiquitin ligase 
               
               
                   
                 22 os =  homo sapiens  gn = klhl22 
                   
                   
                 complex 
               
               
                   
                 pe = 1 sv = 2 
               
               
                 KH 23 
                 IPI00917278 
                 FrIV 
               
               
                 KH 24 
                 IPI00966721 
                 Apolipoprotein 
                 same as 
               
               
                   
                   
                 complex 
                 KH 20 
               
               
                 KH 25 
                 IPI01012037 
                 Apolipoprotein 
                 IPI01012037 
                 mcm8_humandna helicase mcm8 
               
               
                   
                   
                 complex 
                   
                 os =  homo sapiens  gn = mcm8 
               
               
                   
                   
                   
                   
                 pe = 1 sv = 2 
               
               
                 IPI01012037 
                 mcm8_humandna helicase mcm8 
                 P 
                 GO:0051329 
                 interphase of mitotic cell cycle 
               
               
                   
                 os =  homo sapiens  gn = mcm8 
               
               
                   
                 pe = 1 sv = 2 
               
               
                 IPI01012037 
                 mcm8_humandna helicase mcm8 
                 P 
                 GO:0034645 
                 cellular macromolecule 
               
               
                   
                 os =  homo sapiens  gn = mcm8 
                   
                   
                 biosynthetic process 
               
               
                   
                 pe = 1 sv = 2 
               
               
                 IPI01012037 
                 mcm8_humandna helicase mcm8 
                 P 
                 GO:0090304 
                 nucleic acid metabolic process 
               
               
                   
                 os =  homo sapiens  gn = mcm8 
               
               
                   
                 pe = 1 sv = 2 
               
               
                 KH 26 
                 IPI00940730 
                 Apolipoprotein 
                 IPI00940730 
                 enoph_humanenolase- 
               
               
                   
                   
                 complex 
                   
                 phosphatase e1 os =  homo sapiens   
               
               
                   
                   
                   
                   
                 gn = enoph1 pe = 1 sv = 1 
               
               
                 IPI00940730 
                 enoph_humanenolase- 
                 P 
                 GO:0019509 
                 L-methionine salvage from 
               
               
                   
                 phosphatase e1 os =  homo sapiens   
                   
                   
                 methylthioadenosine 
               
               
                   
                 gn = enoph1 pe = 1 sv = 1 
               
               
                 IPI00940730 
                 enoph_humanenolase- 
                 F 
                 GO:0043874 
                 acireductone synthase activity 
               
               
                   
                 phosphatase e1 os =  homo sapiens   
               
               
                   
                 gn = enoph1 pe = 1 sv = 1 
               
               
                 KH 27 
                 IPI00977191 
                 Apolipoprotein 
               
               
                   
                   
                 complex 
               
               
                 KH 28 
                 IPI00022434 
                 HemoRAAS 
                 IPI00022434 
                 albu_humanserum albumin 
               
               
                   
                   
                   
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                   
                   
                   
                 sv = 2 
               
               
                 IPI00022434 
                 albu_humanserum albumin 
                 P 
                 GO:0008202 
                 steroid metabolic process 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00022434 
                 albu_humanserum albumin 
                 P 
                 GO:0051704 
                 multi-organism process 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00022434 
                 albu_humanserum albumin 
                 C 
                 GO:0044446 
                 intracellular organelle part 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00022434 
                 albu_humanserum albumin 
                 P 
                 GO:0051641 
                 cellular localization 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00022434 
                 albu_humanserum albumin 
                 P 
                 GO:0051716 
                 cellular response to stimulus 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00022434 
                 albu_humanserum albumin 
                 F 
                 GO:0008289 
                 lipid binding 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00022434 
                 albu_humanserum albumin 
                 P 
                 GO:0043069 
                 negative regulation of 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
                   
                   
                 programmed cell death 
               
               
                   
                 sv = 2 
               
               
                 IPI00022434 
                 albu_humanserum albumin 
                 P 
                 GO:0044260 
                 cellular macromolecule 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
                   
                   
                 metabolic process 
               
               
                   
                 sv = 2 
               
               
                 IPI00022434 
                 albu_humanserum albumin 
                 P 
                 GO:0031667 
                 response to nutrient levels 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00022434 
                 albu_humanserum albumin 
                 C 
                 GO:0043231 
                 intracellular membrane-bounded 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
                   
                   
                 organelle 
               
               
                   
                 sv = 2 
               
               
                 IPI00022434 
                 albu_humanserum albumin 
                 P 
                 GO:0044281 
                 small molecule metabolic 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
                   
                   
                 process 
               
               
                   
                 sv = 2 
               
               
                 IPI00022434 
                 albu_humanserum albumin 
                 F 
                 GO:0005515 
                 protein binding 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00022434 
                 albu_humanserum albumin 
                 P 
                 GO:0006810 
                 transport 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00022434 
                 albu_humanserum albumin 
                 P 
                 GO:0065008 
                 regulation of biological quality 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00022434 
                 albu_humanserum albumin 
                 P 
                 GO:0007154 
                 cell communication 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00022434 
                 albu_humanserum albumin 
                 F 
                 GO:0019842 
                 vitamin binding 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00022434 
                 albu_humanserum albumin 
                 P 
                 GO:0006950 
                 response to stress 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00022434 
                 albu_humanserum albumin 
                 C 
                 GO:0044444 
                 cytoplasmic part 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00022434 
                 albu_humanserum albumin 
                 P 
                 GO:0032501 
                 multicellular organismal process 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00022434 
                 albu_humanserum albumin 
                 C 
                 GO:0044421 
                 extracellular region part 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 KH 29 
                 IPI00022434 
                 HemoRAAS 
                 same as 
               
               
                   
                   
                   
                 KH 28 
               
               
                 KH 30 
                 IPI00219713 
                 FibroRAAS 
                 IPI00219713 
                 fibg_humanfibrinogen gamma 
               
               
                   
                   
                   
                   
                 chain os =  homo sapiens  gn = fgg 
               
               
                   
                   
                   
                   
                 pe = 1 sv = 3 
               
               
                 IPI00219713 
                 fibg_humanfibrinogen gamma 
                 P 
                 GO:0009987 
                 cellular process 
               
               
                   
                 chain os =  homo sapiens  gn = fgg 
               
               
                   
                 pe = 1 sv = 3 
               
               
                 IPI00219713 
                 fibg_humanfibrinogen gamma 
                 C 
                 GO:0009897 
                 external side of plasma 
               
               
                   
                 chain os =  homo sapiens  gn = fgg 
                   
                   
                 membrane 
               
               
                   
                 pe = 1 sv = 3 
               
               
                 IPI00219713 
                 fibg_humanfibrinogen gamma 
                 F 
                 GO:0043499 
                 eukaryotic cell surface binding 
               
               
                   
                 chain os =  homo sapiens  gn = fgg 
               
               
                   
                 pe = 1 sv = 3 
               
               
                 IPI00219713 
                 fibg_humanfibrinogen gamma 
                 C 
                 GO:0005615 
                 extracellular space 
               
               
                   
                 chain os =  homo sapiens  gn = fgg 
               
               
                   
                 pe = 1 sv = 3 
               
               
                 IPI00219713 
                 fibg_humanfibrinogen gamma 
                 C 
                 GO:0031091 
                 platelet alpha granule 
               
               
                   
                 chain os =  homo sapiens  gn = fgg 
               
               
                   
                 pe = 1 sv = 3 
               
               
                 IPI00219713 
                 fibg_humanfibrinogen gamma 
                 P 
                 GO:0032501 
                 multicellular organismal process 
               
               
                   
                 chain os =  homo sapiens  gn = fgg 
               
               
                   
                 pe = 1 sv = 3 
               
               
                 IPI00219713 
                 fibg_humanfibrinogen gamma 
                 P 
                 GO:0065007 
                 biological regulation 
               
               
                   
                 chain os =  homo sapiens  gn = fgg 
               
               
                   
                 pe = 1 sv = 3 
               
               
                 IPI00219713 
                 fibg_humanfibrinogen gamma 
                 P 
                 GO:0051592 
                 response to calcium ion 
               
               
                   
                 chain os =  homo sapiens  gn = fgg 
               
               
                   
                 pe = 1 sv = 3 
               
               
                 KH 31 
                 IPI00219713 
                 FibroRAAS 
                 same as 
               
               
                   
                   
                   
                 KH 30 
               
               
                 KH 32 
                 IPI00220327 
                 FibroRAAS 
                 IPI00220327 
                 type ii cytoskeletal 1 os =  homo   
               
               
                   
                   
                   
                   
                   sapiens  gn = krt1 pe = 1 sv = 6 
               
               
                 IPI00220327 
                 type ii cytoskeletal 1 os =  homo   
                 P 
                 GO:0009987 
                 cellular process 
               
               
                   
                   sapiens  gn = krt1 pe = 1 sv = 6 
               
               
                 IPI00220327 
                 type ii cytoskeletal 1 os =  homo   
                 P 
                 GO:0048731 
                 system development 
               
               
                   
                   sapiens  gn = krt1 pe = 1 sv = 6 
               
               
                 IPI00220327 
                 type ii cytoskeletal 1 os =  homo   
                 P 
                 GO:0009888 
                 tissue development 
               
               
                   
                   sapiens  gn = krt1 pe = 1 sv = 6 
               
               
                 IPI00220327 
                 type ii cytoskeletal 1 os =  homo   
                 C 
                 GO:0005856 
                 cytoskeleton 
               
               
                   
                   sapiens  gn = krt1 pe = 1 sv = 6 
               
               
                 IPI00220327 
                 type ii cytoskeletal 1 os =  homo   
                 F 
                 GO:0005515 
                 protein binding 
               
               
                   
                   sapiens  gn = krt1 pe = 1 sv = 6 
               
               
                 IPI00220327 
                 type ii cytoskeletal 1 os =  homo   
                 P 
                 GO:0001867 
                 complement activation, lectin 
               
               
                   
                   sapiens  gn = krt1 pe = 1 sv = 6 
                   
                   
                 pathway 
               
               
                 IPI00220327 
                 type ii cytoskeletal 1 os =  homo   
                 F 
                 GO:0030246 
                 carbohydrate binding 
               
               
                   
                   sapiens  gn = krt1 pe = 1 sv = 6 
               
               
                 IPI00220327 
                 type ii cytoskeletal 1 os =  homo   
                 C 
                 GO:0016020 
                 membrane 
               
               
                   
                   sapiens  gn = krt1 pe = 1 sv = 6 
               
               
                 KH 33 
                 IPI00029739 
                 GammaRAAS 
                 IPI00029739 
                 cfah_humancomplement factor h 
               
               
                   
                   
                   
                   
                 os =  homo sapiens  gn = cfh pe = 1 
               
               
                   
                   
                   
                   
                 sv = 4 
               
               
                 IPI00029739 
                 cfah_humancomplement factor h 
                 P 
                 GO:0030449 
                 regulation of complement 
               
               
                   
                 os =  homo sapiens  gn = cfh pe = 1 
                   
                   
                 activation 
               
               
                   
                 sv = 4 
               
               
                 IPI00029739 
                 cfah_humancomplement factor h 
                 P 
                 GO:0045087 
                 innate immune response 
               
               
                   
                 os =  homo sapiens  gn = cfh pe = 1 
               
               
                   
                 sv = 4 
               
               
                 KH 34 
                 IPI00384853 
                 GammaRAAS 
               
               
                 KH 35 
                 IPI00479708 
                 GammaRAAS 
                 IPI00479708 
                 ighm_humanig mu chain c region 
               
               
                   
                   
                   
                   
                 os =  homo sapiens  gn = ighm pe = 1 
               
               
                   
                   
                   
                   
                 sv = 3 
               
               
                 IPI00479708 
                 ighm_humanig mu chain c region 
                 F 
                 GO:0005488 
                 binding 
               
               
                   
                 os =  homo sapiens  gn = ighm pe = 1 
               
               
                   
                 sv = 3 
               
               
                 IPI00479708 
                 ighm_humanig mu chain c region 
                 C 
                 GO:0044464 
                 cell part 
               
               
                   
                 os =  homo sapiens  gn = ighm pe = 1 
               
               
                   
                 sv = 3 
               
               
                 IPI00479708 
                 ighm_humanig mu chain c region 
                 C 
                 GO:0016020 
                 membrane 
               
               
                   
                 os =  homo sapiens  gn = ighm pe = 1 
               
               
                   
                 sv = 3 
               
               
                 IPI00479708 
                 ighm_humanig mu chain c region 
                 P 
                 GO:0006955 
                 immune response 
               
               
                   
                 os =  homo sapiens  gn = ighm pe = 1 
               
               
                   
                 sv = 3 
               
               
                 KH 36 
                 IPI00298497 
                 GammaRAAS 
                 IPI00298497 
                 fibb_humanfibrinogen beta chain 
               
               
                   
                   
                   
                   
                 os =  homo sapiens  gn = fgb pe = 1 
               
               
                   
                   
                   
                   
                 sv = 2 
               
               
                 IPI00298497 
                 fibb_humanfibrinogen beta chain 
                 F 
                 GO:0051087 
                 chaperone binding 
               
               
                   
                 os =  homo sapiens  gn = fgb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00298497 
                 fibb_humanfibrinogen beta chain 
                 P 
                 GO:0051592 
                 response to calcium ion 
               
               
                   
                 os =  homo sapiens  gn = fgb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00298497 
                 fibb_humanfibrinogen beta chain 
                 C 
                 GO:0005615 
                 extracellular space 
               
               
                   
                 os =  homo sapiens  gn = fgb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00298497 
                 fibb_humanfibrinogen beta chain 
                 P 
                 GO:0051179 
                 localization 
               
               
                   
                 os =  homo sapiens  gn = fgb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00298497 
                 fibb_humanfibrinogen beta chain 
                 C 
                 GO:0031091 
                 platelet alpha granule 
               
               
                   
                 os =  homo sapiens  gn = fgb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00298497 
                 fibb_humanfibrinogen beta chain 
                 C 
                 GO:0009897 
                 external side of plasma 
               
               
                   
                 os =  homo sapiens  gn = fgb pe = 1 
                   
                   
                 membrane 
               
               
                   
                 sv = 2 
               
               
                 IPI00298497 
                 fibb_humanfibrinogen beta chain 
                 P 
                 GO:0050794 
                 regulation of cellular process 
               
               
                   
                 os =  homo sapiens  gn = fgb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00298497 
                 fibb_humanfibrinogen beta chain 
                 P 
                 GO:0006950 
                 response to stress 
               
               
                   
                 os =  homo sapiens  gn = fgb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00298497 
                 fibb_humanfibrinogen beta chain 
                 F 
                 GO:0043499 
                 eukaryotic cell surface binding 
               
               
                   
                 os =  homo sapiens  gn = fgb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00298497 
                 fibb_humanfibrinogen beta chain 
                 P 
                 GO:0032501 
                 multicellular organismal process 
               
               
                   
                 os =  homo sapiens  gn = fgb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 KH 37 
                 IPI00021841 
                 GammaRAAS 
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
               
               
                   
                   
                   
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                   
                   
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0070508 
                 cholesterol import 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 C 
                 GO:0030139 
                 endocytic vesicle 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0050728 
                 negative regulation of 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 inflammatory response 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0033344 
                 cholesterol efflux 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0034115 
                 negative regulation of 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 heterotypic cell-cell adhesion 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0018206 
                 peptidyl-methionine 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 modification 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0042157 
                 lipoprotein metabolic process 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0043691 
                 reverse cholesterol transport 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 F 
                 GO:0005543 
                 phospholipid binding 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0002740 
                 negative regulation of cytokine 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 secretion involved in immune 
               
               
                   
                 sv = 1 
                   
                   
                 response 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0008203 
                 cholesterol metabolic process 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0050713 
                 negative regulation of 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 interleukin-1 beta secretion 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0018158 
                 protein oxidation 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0006656 
                 phosphatidylcholine biosynthetic 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 process 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 F 
                 GO:0001540 
                 beta-amyloid binding 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 F 
                 GO:0060228 
                 phosphatidylcholine-sterol O- 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 acyltransferase activator activity 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0042632 
                 cholesterol homeostasis 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 F 
                 GO:0015485 
                 cholesterol binding 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0042060 
                 wound healing 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 F 
                 GO:0034191 
                 apolipoprotein A-I receptor 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 binding 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 F 
                 GO:0042802 
                 identical protein binding 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0010903 
                 negative regulation of very-low- 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 density lipoprotein particle 
               
               
                   
                 sv = 1 
                   
                   
                 remodeling 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0010804 
                 negative regulation of tumor 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 necrosis factor-mediated 
               
               
                   
                 sv = 1 
                   
                   
                 signaling pathway 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0034380 
                 high-density lipoprotein particle 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 assembly 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0007186 
                 G-protein coupled receptor 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 signaling pathway 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0050821 
                 protein stabilization 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 C 
                 GO:0034361 
                 very-low-density lipoprotein 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 particle 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0032488 
                 Cdc42 protein signal 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 transduction 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0060354 
                 negative regulation of cell 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 adhesion molecule production 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0055091 
                 phospholipid homeostasis 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0010873 
                 positive regulation of cholesterol 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 esterification 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 F 
                 GO:0017127 
                 cholesterol transporter activity 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 F 
                 GO:0019899 
                 enzyme binding 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 F 
                 GO:0070653 
                 high-density lipoprotein particle 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 receptor binding 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0070328 
                 triglyceride homeostasis 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 C 
                 GO:0034366 
                 spherical high-density 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 lipoprotein particle 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0033700 
                 phospholipid efflux 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
               
               
                   
                 sv = 1 
               
               
                 IPI00021841 
                 apoa1_humanapolipoprotein a-i 
                 P 
                 GO:0051345 
                 positive regulation of hydrolase 
               
               
                   
                 os =  homo sapiens  gn = apoa1 pe = 1 
                   
                   
                 activity 
               
               
                   
                 sv = 1 
               
               
                 KH 38 
                 IPI00783987 
                 AFCC 
                 IPI00783987 
                 co3_humancomplement c3 
               
               
                   
                   
                   
                   
                 os =  homo sapiens  gn = c3 pe = 1 
               
               
                   
                   
                   
                   
                 sv = 2 
               
               
                 IPI00783987 
                 co3_humancomplement c3 
                 C 
                 GO:0044464 
                 cell part 
               
               
                   
                 os =  homo sapiens  gn = c3 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00783987 
                 co3_humancomplement c3 
                 P 
                 GO:0010575 
                 positive regulation vascular 
               
               
                   
                 os =  homo sapiens  gn = c3 pe = 1 
                   
                   
                 endothelial growth factor 
               
               
                   
                 sv = 2 
                   
                   
                 production 
               
               
                 IPI00783987 
                 co3_humancomplement c3 
                 P 
                 GO:0030449 
                 regulation of complement 
               
               
                   
                 os =  homo sapiens  gn = c3 pe = 1 
                   
                   
                 activation 
               
               
                   
                 sv = 2 
               
               
                 IPI00783987 
                 co3_humancomplement c3 
                 P 
                 GO:0007165 
                 signal transduction 
               
               
                   
                 os =  homo sapiens  gn = c3 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00783987 
                 co3_humancomplement c3 
                 P 
                 GO:0045087 
                 innate immune response 
               
               
                   
                 os =  homo sapiens  gn = c3 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00783987 
                 co3_humancomplement c3 
                 F 
                 GO:0005515 
                 protein binding 
               
               
                   
                 os =  homo sapiens  gn = c3 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00783987 
                 co3_humancomplement c3 
                 C 
                 GO:0016020 
                 membrane 
               
               
                   
                 os =  homo sapiens  gn = c3 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 KH 39 
                 IPI00878282 
                 AFCC 
                 IPI00878282 
                 albu_humanserum albumin 
               
               
                   
                   
                   
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                   
                   
                   
                 sv = 2 
               
               
                 IPI00878282 
                 albu_humanserum albumin 
                 P 
                 GO:0008202 
                 steroid metabolic process 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00878282 
                 albu_humanserum albumin 
                 F 
                 GO:0051087 
                 chaperone binding 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00878282 
                 albu_humanserum albumin 
                 C 
                 GO:0044446 
                 intracellular organelle part 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00878282 
                 albu_humanserum albumin 
                 F 
                 GO:0015643 
                 toxin binding 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00878282 
                 albu_humanserum albumin 
                 P 
                 GO:0044260 
                 cellular macromolecule 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
                   
                   
                 metabolic process 
               
               
                   
                 sv = 2 
               
               
                 IPI00878282 
                 albu_humanserum albumin 
                 C 
                 GO:0005615 
                 extracellular space 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00878282 
                 albu_humanserum albumin 
                 P 
                 GO:0051659 
                 maintenance of mitochondrion 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
                   
                   
                 location 
               
               
                   
                 sv = 2 
               
               
                 IPI00878282 
                 albu_humanserum albumin 
                 F 
                 GO:0008144 
                 drug binding 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00878282 
                 albu_humanserum albumin 
                 C 
                 GO:0043231 
                 intracellular membrane-bounded 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
                   
                   
                 organelle 
               
               
                   
                 sv = 2 
               
               
                 IPI00878282 
                 albu_humanserum albumin 
                 P 
                 GO:0044281 
                 small molecule metabolic 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
                   
                   
                 process 
               
               
                   
                 sv = 2 
               
               
                 IPI00878282 
                 albu_humanserum albumin 
                 F 
                 GO:0005504 
                 fatty acid binding 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00878282 
                 albu_humanserum albumin 
                 P 
                 GO:0042221 
                 response to chemical stimulus 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00878282 
                 albu_humanserum albumin 
                 F 
                 GO:0003677 
                 DNA binding 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00878282 
                 albu_humanserum albumin 
                 P 
                 GO:0009267 
                 cellular response to starvation 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00878282 
                 albu_humanserum albumin 
                 F 
                 GO:0030170 
                 pyridoxal phosphate binding 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00878282 
                 albu_humanserum albumin 
                 P 
                 GO:0006810 
                 transport 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00878282 
                 albu_humanserum albumin 
                 F 
                 GO:0019825 
                 oxygen binding 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00878282 
                 albu_humanserum albumin 
                 P 
                 GO:0050878 
                 regulation of body fluid levels 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00878282 
                 albu_humanserum albumin 
                 P 
                 GO:0043066 
                 negative regulation of apoptotic 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
                   
                   
                 process 
               
               
                   
                 sv = 2 
               
               
                 IPI00878282 
                 albu_humanserum albumin 
                 C 
                 GO:0044444 
                 cytoplasmic part 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00878282 
                 albu_humanserum albumin 
                 P 
                 GO:0009611 
                 response to wounding 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00878282 
                 albu_humanserum albumin 
                 P 
                 GO:0019836 
                 hemolysis by symbiont of host 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
                   
                   
                 erythrocytes 
               
               
                   
                 sv = 2 
               
               
                 IPI00878282 
                 albu_humanserum albumin 
                 P 
                 GO:0006955 
                 immune response 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00878282 
                 albu_humanserum albumin 
                 C 
                 GO:0019814 
                 immunoglobulin complex 
               
               
                   
                 os =  homo sapiens  gn = alb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00784842 
                 ighg1_humanig gamma-1 chain c 
                 P 
                 GO:0050776 
                 regulation of immune response 
               
               
                   
                 region os =  homo sapiens   
               
               
                   
                 gn = ighg1 pe = 1 sv = 1 
               
               
                 IPI00784842 
                 ighg1_humanig gamma-1 chain c 
                 F 
                 GO:0005515 
                 protein binding 
               
               
                   
                 region os =  homo sapiens   
               
               
                   
                 gn = ighg1 pe = 1 sv = 1 
               
               
                 KH 40 
                 IPI00784842 
                 AFCC 
                 IPI00784842 
                 ighg1_humanig gamma-1 chain c 
               
               
                   
                   
                   
                   
                 region os =  homo sapiens   
               
               
                   
                   
                   
                   
                 gn = ighg1 pe = 1 sv = 1 
               
               
                 IPI00784842 
                 ighg1_humanig gamma-1 chain c 
                 P 
                 GO:0050776 
                 regulation of immune response 
               
               
                   
                 region os =  homo sapiens   
               
               
                   
                 gn = ighg1 pe = 1 sv = 1 
               
               
                 IPI00784842 
                 ighg1_humanig gamma-1 chain c 
                 F 
                 GO:0005515 
                 protein binding 
               
               
                   
                 region os =  homo sapiens   
               
               
                   
                 gn = ighg1 pe = 1 sv = 1 
               
               
                 KH 41 
                 IPI00022434 
                 Fraction III-II 
                 same as 
               
               
                   
                   
                   
                 KH 28 
               
               
                 KH 42 
                 IPI00298497 
                 Fraction III 
                 same as 
               
               
                   
                   
                   
                 KH 36 
               
               
                 KH 43 
                 IPI00965713 
                 Fraction III 
                 IPI00965713 
                 fibb_humanfibrinogen beta chain 
               
               
                   
                   
                   
                   
                 os =  homo sapiens  gn = fgb pe = 1 
               
               
                   
                   
                   
                   
                 sv = 2 
               
               
                 IPI00965713 
                 fibb_humanfibrinogen beta chain 
                 P 
                 GO:0042221 
                 response to chemical stimulus 
               
               
                   
                 os =  homo sapiens  gn = fgb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00965713 
                 fibb_humanfibrinogen beta chain 
                 F 
                 GO:0005515 
                 protein binding 
               
               
                   
                 os =  homo sapiens  gn = fgb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00965713 
                 fibb_humanfibrinogen beta chain 
                 C 
                 GO:0005615 
                 extracellular space 
               
               
                   
                 os =  homo sapiens  gn = fgb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00965713 
                 fibb_humanfibrinogen beta chain 
                 P 
                 GO:0051179 
                 localization 
               
               
                   
                 os =  homo sapiens  gn = fgb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00965713 
                 fibb_humanfibrinogen beta chain 
                 C 
                 GO:0031091 
                 platelet alpha granule 
               
               
                   
                 os =  homo sapiens  gn = fgb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00965713 
                 fibb_humanfibrinogen beta chain 
                 C 
                 GO:0044425 
                 membrane part 
               
               
                   
                 os =  homo sapiens  gn = fgb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00965713 
                 fibb_humanfibrinogen beta chain 
                 P 
                 GO:0050794 
                 regulation of cellular process 
               
               
                   
                 os =  homo sapiens  gn = fgb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00965713 
                 fibb_humanfibrinogen beta chain 
                 P 
                 GO:0006950 
                 response to stress 
               
               
                   
                 os =  homo sapiens  gn = fgb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00965713 
                 fibb_humanfibrinogen beta chain 
                 C 
                 GO:0005886 
                 plasma membrane 
               
               
                   
                 os =  homo sapiens  gn = fgb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 IPI00965713 
                 fibb_humanfibrinogen beta chain 
                 P 
                 GO:0032501 
                 multicellular organismal process 
               
               
                   
                 os =  homo sapiens  gn = fgb pe = 1 
               
               
                   
                 sv = 2 
               
               
                 KH 44 
                 IPI00645363 
                 FibringluRAAS ® 
                 IPI00645363 
                 ighg1_humanig gamma-1 chain c 
               
               
                   
                   
                 Human 
                   
                 region os =  homo sapiens   
               
               
                   
                   
                 Thrombin 
                   
                 gn = ighg1 pe = 1 sv = 1 
               
               
                 IPI00645363 
                 ighg1_humanig gamma-1 chain c 
                 P 
                 GO:0050776 
                 regulation of immune response 
               
               
                   
                 region os =  homo sapiens   
               
               
                   
                 gn = ighg1 pe = 1 sv = 1 
               
               
                 IPI00645363 
                 ighg1_humanig gamma-1 chain c 
                 F 
                 GO:0005515 
                 protein binding 
               
               
                   
                 region os =  homo sapiens   
               
               
                   
                 gn = ighg1 pe = 1 sv = 1 
               
               
                 KH 45 
                 IPI00219713 
                 FibringluRAAS ® 
                 same as 
               
               
                   
                   
                 Human 
                 KH 30 
               
               
                   
                   
                 Thrombin 
               
               
                 IPI00219713 
                 fibg_humanfibrinogen gamma 
                 P 
                 GO:0009987 
                 cellular process 
               
               
                   
                 chain os =  homo sapiens  gn = fgg 
               
               
                   
                 pe = 1 sv = 3 
               
               
                 IPI00219713 
                 fibg_humanfibrinogen gamma 
                 C 
                 GO:0009897 
                 external side of plasma 
               
               
                   
                 chain os =  homo sapiens  gn = fgg 
                   
                   
                 membrane 
               
               
                   
                 pe = 1 sv = 3 
               
               
                 IPI00219713 
                 fibg_humanfibrinogen gamma 
                 F 
                 GO:0043499 
                 eukaryotic cell surface binding 
               
               
                   
                 chain os =  homo sapiens  gn = fgg 
               
               
                   
                 pe = 1 sv = 3 
               
               
                 IPI00219713 
                 fibg_humanfibrinogen gamma 
                 C 
                 GO:0005615 
                 extracellular space 
               
               
                   
                 chain os =  homo sapiens  gn = fgg 
               
               
                   
                 pe = 1 sv = 3 
               
               
                 IPI00219713 
                 fibg_humanfibrinogen gamma 
                 C 
                 GO:0031091 
                 platelet alpha granule 
               
               
                   
                 chain os =  homo sapiens  gn = fgg 
               
               
                   
                 pe = 1 sv = 3 
               
               
                 IPI00219713 
                 fibg_humanfibrinogen gamma 
                 P 
                 GO:0032501 
                 multicellular organismal process 
               
               
                   
                 chain os =  homo sapiens  gn = fgg 
               
               
                   
                 pe = 1 sv = 3 
               
               
                 IPI00219713 
                 fibg_humanfibrinogen gamma 
                 P 
                 GO:0065007 
                 biological regulation 
               
               
                   
                 chain os =  homo sapiens  gn = fgg 
               
               
                   
                 pe = 1 sv = 3 
               
               
                 IPI00219713 
                 fibg_humanfibrinogen gamma 
                 P 
                 GO:0051592 
                 response to calcium ion 
               
               
                   
                 chain os =  homo sapiens  gn = fgg 
               
               
                   
                 pe = 1 sv = 3 
               
               
                 KH 46 
                 IPI00022371 
                 FibringluRAAS ® 
                 IPI00022371 
                 hrg_humanhistidine-rich 
               
               
                   
                   
                 Human 
                   
                 glycoprotein os =  homo sapiens   
               
               
                   
                   
                 Thrombin 
                   
                 gn = hrg pe = 1 sv = 1 
               
               
                 IPI00022371 
                 hrg_humanhistidine-rich 
                 P 
                 GO:0043065 
                 positive regulation of apoptotic 
               
               
                   
                 glycoprotein os =  homo sapiens   
                   
                   
                 process 
               
               
                   
                 gn = hrg pe = 1 sv = 1 
               
               
                 IPI00022371 
                 hrg_humanhistidine-rich 
                 P 
                 GO:0010468 
                 regulation of gene expression 
               
               
                   
                 glycoprotein os =  homo sapiens   
               
               
                   
                 gn = hrg pe = 1 sv = 1 
               
               
                 IPI00022371 
                 hrg_humanhistidine-rich 
                 P 
                 GO:0032956 
                 regulation of actin cytoskeleton 
               
               
                   
                 glycoprotein os =  homo sapiens   
                   
                   
                 organization 
               
               
                   
                 gn = hrg pe = 1 sv = 1 
               
               
                 IPI00022371 
                 hrg_humanhistidine-rich 
                 P 
                 GO:0016525 
                 negative regulation of 
               
               
                   
                 glycoprotein os =  homo sapiens   
                   
                   
                 angiogenesis 
               
               
                   
                 gn = hrg pe = 1 sv = 1 
               
               
                 IPI00022371 
                 hrg_humanhistidine-rich 
                 P 
                 GO:2000504 
                 positive regulation of blood 
               
               
                   
                 glycoprotein os =  homo sapiens   
                   
                   
                 vessel remodeling 
               
               
                   
                 gn = hrg pe = 1 sv = 1 
               
               
                 IPI00022371 
                 hrg_humanhistidine-rich 
                 P 
                 GO:0043254 
                 regulation of protein complex 
               
               
                   
                 glycoprotein os =  homo sapiens   
                   
                   
                 assembly 
               
               
                   
                 gn = hrg pe = 1 sv = 1 
               
               
                 IPI00022371 
                 hrg_humanhistidine-rich 
                 P 
                 GO:0002839 
                 positive regulation of immune 
               
               
                   
                 glycoprotein os =  homo sapiens   
                   
                   
                 response to tumor cell 
               
               
                   
                 gn = hrg pe = 1 sv = 1 
               
               
                 IPI00022371 
                 hrg_humanhistidine-rich 
                 F 
                 GO:0008201 
                 heparin binding 
               
               
                   
                 glycoprotein os =  homo sapiens   
               
               
                   
                 gn = hrg pe = 1 sv = 1 
               
               
                 IPI00022371 
                 hrg_humanhistidine-rich 
                 P 
                 GO:0010593 
                 negative regulation of 
               
               
                   
                 glycoprotein os =  homo sapiens   
                   
                   
                 lamellipodium assembly 
               
               
                   
                 gn = hrg pe = 1 sv = 1 
               
               
                 IPI00022371 
                 hrg_humanhistidine-rich 
                 P 
                 GO:0050832 
                 defense response to fungus 
               
               
                   
                 glycoprotein os =  homo sapiens   
               
               
                   
                 gn = hrg pe = 1 sv = 1 
               
               
                 IPI00022371 
                 hrg_humanhistidine-rich 
                 F 
                 GO:0020037 
                 heme binding 
               
               
                   
                 glycoprotein os =  homo sapiens   
               
               
                   
                 gn = hrg pe = 1 sv = 1 
               
               
                 IPI00022371 
                 hrg_humanhistidine-rich 
                 F 
                 GO:0019865 
                 immunoglobulin binding 
               
               
                   
                 glycoprotein os =  homo sapiens   
               
               
                   
                 gn = hrg pe = 1 sv = 1 
               
               
                 IPI00022371 
                 hrg_humanhistidine-rich 
                 P 
                 GO:0030168 
                 platelet activation 
               
               
                   
                 glycoprotein os =  homo sapiens   
               
               
                   
                 gn = hrg pe = 1 sv = 1 
               
               
                 IPI00022371 
                 hrg_humanhistidine-rich 
                 F 
                 GO:0043395 
                 heparan sulfate proteoglycan 
               
               
                   
                 glycoprotein os =  homo sapiens   
                   
                   
                 binding 
               
               
                   
                 gn = hrg pe = 1 sv = 1 
               
               
                 IPI00022371 
                 hrg_humanhistidine-rich 
                 P 
                 GO:1900747 
                 negative regulation of vascular 
               
               
                   
                 glycoprotein os =  homo sapiens   
                   
                   
                 endothelial growth factor 
               
               
                   
                 gn = hrg pe = 1 sv = 1 
                   
                   
                 signaling pathway 
               
               
                 IPI00022371 
                 hrg_humanhistidine-rich 
                 F 
                 GO:0008270 
                 zinc ion binding 
               
               
                   
                 glycoprotein os =  homo sapiens   
               
               
                   
                 gn = hrg pe = 1 sv = 1 
               
               
                 IPI00022371 
                 hrg_humanhistidine-rich 
                 F 
                 GO:0043498 
                 cell surface binding 
               
               
                   
                 glycoprotein os =  homo sapiens   
               
               
                   
                 gn = hrg pe = 1 sv = 1 
               
               
                 IPI00022371 
                 hrg_humanhistidine-rich 
                 P 
                 GO:2001027 
                 negative regulation of endothelial 
               
               
                   
                 glycoprotein os =  homo sapiens   
                   
                   
                 cell chemotaxis 
               
               
                   
                 gn = hrg pe = 1 sv = 1 
               
               
                 IPI00022371 
                 hrg_humanhistidine-rich 
                 P 
                 GO:0008285 
                 negative regulation of cell 
               
               
                   
                 glycoprotein os =  homo sapiens   
                   
                   
                 proliferation 
               
               
                   
                 gn = hrg pe = 1 sv = 1 
               
               
                 IPI00022371 
                 hrg_humanhistidine-rich 
                 P 
                 GO:0051894 
                 positive regulation of focal 
               
               
                   
                 glycoprotein os =  homo sapiens   
                   
                   
                 adhesion assembly 
               
               
                   
                 gn = hrg pe = 1 sv = 1 
               
               
                 IPI00022371 
                 hrg_humanhistidine-rich 
                 P 
                 GO:0030193 
                 regulation of blood coagulation 
               
               
                   
                 glycoprotein os =  homo sapiens   
               
               
                   
                 gn = hrg pe = 1 sv = 1 
               
               
                 IPI00022371 
                 hrg_humanhistidine-rich 
                 P 
                 GO:0050730 
                 regulation of peptidyl-tyrosine 
               
               
                   
                 glycoprotein os =  homo sapiens   
                   
                   
                 phosphorylation 
               
               
                   
                 gn = hrg pe = 1 sv = 1 
               
               
                 IPI00022371 
                 hrg_humanhistidine-rich 
                 P 
                 GO:0033629 
                 negative regulation of cell 
               
               
                   
                 glycoprotein os =  homo sapiens   
                   
                   
                 adhesion mediated by integrin 
               
               
                   
                 gn = hrg pe = 1 sv = 1 
               
               
                 IPI00022371 
                 hrg_humanhistidine-rich 
                 P 
                 GO:0030308 
                 negative regulation of cell 
               
               
                   
                 glycoprotein os =  homo sapiens   
                   
                   
                 growth 
               
               
                   
                 gn = hrg pe = 1 sv = 1 
               
               
                 IPI00022371 
                 hrg_humanhistidine-rich 
                 C 
                 GO:0005576 
                 extracellular region 
               
               
                   
                 glycoprotein os =  homo sapiens   
               
               
                   
                 gn = hrg pe = 1 sv = 1 
               
               
                 IPI00022371 
                 hrg_humanhistidine-rich 
                 C 
                 GO:0019814 
                 immunoglobulin complex 
               
               
                   
                 glycoprotein os =  homo sapiens   
               
               
                   
                 gn = hrg pe = 1 sv = 1 
               
               
                 KH 47 
                 IPI00022371 
                 FibringluRAAS ® 
                 same as 
               
               
                   
                   
                 Human 
                 KH 46 
               
               
                   
                   
                 Thrombin 
               
               
                 KH 48 
                 IPI00022463 
                 AFOD 
                 IPI00022463 
                 trfe_humanserotransferrin 
               
               
                   
                   
                   
                   
                 os =  homo sapiens  gn = tf pe = 1 
               
               
                   
                   
                   
                   
                 sv = 3 
               
               
                 IPI00022463 
                 trfe_humanserotransferrin 
                 P 
                 GO:0009987 
                 cellular process 
               
               
                   
                 os =  homo sapiens  gn = tf pe = 1 
               
               
                   
                 sv = 3 
               
               
                 IPI00022463 
                 trfe_humanserotransferrin 
                 P 
                 GO:0065008 
                 regulation of biological quality 
               
               
                   
                 os =  homo sapiens  gn = tf pe = 1 
               
               
                   
                 sv = 3 
               
               
                 IPI00022463 
                 trfe_humanserotransferrin 
                 P 
                 GO:0006810 
                 transport 
               
               
                   
                 os =  homo sapiens  gn = tf pe = 1 
               
               
                   
                 sv = 3 
               
               
                 IPI00022463 
                 trfe_humanserotransferrin 
                 C 
                 GO:0009925 
                 basal plasma membrane 
               
               
                   
                 os =  homo sapiens  gn = tf pe = 1 
               
               
                   
                 sv = 3 
               
               
                 IPI00022463 
                 trfe_humanserotransferrin 
                 C 
                 GO:0005739 
                 mitochondrion 
               
               
                   
                 os =  homo sapiens  gn = tf pe = 1 
               
               
                   
                 sv = 3 
               
               
                 IPI00022463 
                 trfe_humanserotransferrin 
                 C 
                 GO:0030139 
                 endocytic vesicle 
               
               
                   
                 os =  homo sapiens  gn = tf pe = 1 
               
               
                   
                 sv = 3 
               
               
                 IPI00022463 
                 trfe_humanserotransferrin 
                 C 
                 GO:0005905 
                 coated pit 
               
               
                   
                 os =  homo sapiens  gn = tf pe = 1 
               
               
                   
                 sv = 3 
               
               
                 IPI00022463 
                 trfe_humanserotransferrin 
                 C 
                 GO:0005770 
                 late endosome 
               
               
                   
                 os =  homo sapiens  gn = tf pe = 1 
               
               
                   
                 sv = 3 
               
               
                 IPI00022463 
                 trfe_humanserotransferrin 
                 C 
                 GO:0005769 
                 early endosome 
               
               
                   
                 os =  homo sapiens  gn = tf pe = 1 
               
               
                   
                 sv = 3 
               
               
                 IPI00022463 
                 trfe_humanserotransferrin 
                 C 
                 GO:0055037 
                 recycling endosome 
               
               
                   
                 os =  homo sapiens  gn = tf pe = 1 
               
               
                   
                 sv = 3 
               
               
                 IPI00022463 
                 trfe_humanserotransferrin 
                 F 
                 GO:0005515 
                 protein binding 
               
               
                   
                 os =  homo sapiens  gn = tf pe = 1 
               
               
                   
                 sv = 3 
               
               
                 IPI00022463 
                 trfe_humanserotransferrin 
                 C 
                 GO:0048471 
                 perinuclear region of cytoplasm 
               
               
                   
                 os =  homo sapiens  gn = tf pe = 1 
               
               
                   
                 sv = 3 
               
               
                 IPI00022463 
                 trfe_humanserotransferrin 
                 C 
                 GO:0016324 
                 apical plasma membrane 
               
               
                   
                 os =  homo sapiens  gn = tf pe = 1 
               
               
                   
                 sv = 3 
               
               
                 IPI00022463 
                 trfe_humanserotransferrin 
                 P 
                 GO:0006950 
                 response to stress 
               
               
                   
                 os =  homo sapiens  gn = tf pe = 1 
               
               
                   
                 sv = 3 
               
               
                 KH 49 
                 IPI00023006 
                 AFOD 
                 IPI00023006 
                 alpha cardiac muscle 1 os =  homo   
               
               
                   
                   
                   
                   
                   sapiens  gn = actc1 pe = 1 sv = 1 
               
               
                 IPI00023006 
                 alpha cardiac muscle 1 os =  homo   
                 C 
                 GO:0005865 
                 striated muscle thin filament 
               
               
                   
                   sapiens  gn = actc1 pe = 1 sv = 1 
               
               
                 IPI00023006 
                 alpha cardiac muscle 1 os =  homo   
                 F 
                 GO:0017022 
                 myosin binding 
               
               
                   
                   sapiens  gn = actc1 pe = 1 sv = 1 
               
               
                 IPI00023006 
                 alpha cardiac muscle 1 os =  homo   
                 P 
                 GO:0030240 
                 skeletal muscle thin filament 
               
               
                   
                   sapiens  gn = actc1 pe = 1 sv = 1 
                   
                   
                 assembly 
               
               
                 IPI00023006 
                 alpha cardiac muscle 1 os =  homo   
                 P 
                 GO:0006200 
                 ATP catabolic process 
               
               
                   
                   sapiens  gn = actc1 pe = 1 sv = 1 
               
               
                 IPI00023006 
                 alpha cardiac muscle 1 os =  homo   
                 P 
                 GO:0072144 
                 glomerular mesangial cell 
               
               
                   
                   sapiens  gn = actc1 pe = 1 sv = 1 
                   
                   
                 development 
               
               
                 IPI00023006 
                 alpha cardiac muscle 1 os =  homo   
                 P 
                 GO:0006936 
                 muscle contraction 
               
               
                   
                   sapiens  gn = actc1 pe = 1 sv = 1 
               
               
                 IPI00023006 
                 alpha cardiac muscle 1 os =  homo   
                 P 
                 GO:0033275 
                 actin-myosin filament sliding 
               
               
                   
                   sapiens  gn = actc1 pe = 1 sv = 1 
               
               
                 IPI00023006 
                 alpha cardiac muscle 1 os =  homo   
                 C 
                 GO:0042643 
                 actomyosin, actin part 
               
               
                   
                   sapiens  gn = actc1 pe = 1 sv = 1 
               
               
                 IPI00023006 
                 alpha cardiac muscle 1 os =  homo   
                 P 
                 GO:0042221 
                 response to chemical stimulus 
               
               
                   
                   sapiens  gn = actc1 pe = 1 sv = 1 
               
               
                 IPI00023006 
                 alpha cardiac muscle 1 os =  homo   
                 F 
                 GO:0005524 
                 ATP binding 
               
               
                   
                   sapiens  gn = actc1 pe = 1 sv = 1 
               
               
                 IPI00023006 
                 alpha cardiac muscle 1 os =  homo   
                 C 
                 GO:0001725 
                 stress fiber 
               
               
                   
                   sapiens  gn = actc1 pe = 1 sv = 1 
               
               
                 IPI00023006 
                 alpha cardiac muscle 1 os =  homo   
                 F 
                 GO:0016887 
                 ATPase activity 
               
               
                   
                   sapiens  gn = actc1 pe = 1 sv = 1 
               
               
                 IPI00023006 
                 alpha cardiac muscle 1 os =  homo   
                 P 
                 GO:0065008 
                 regulation of biological quality 
               
               
                   
                   sapiens  gn = actc1 pe = 1 sv = 1 
               
               
                 IPI00023006 
                 alpha cardiac muscle 1 os =  homo   
                 C 
                 GO:0044451 
                 nucleoplasm part 
               
               
                   
                   sapiens  gn = actc1 pe = 1 sv = 1 
               
               
                 IPI00023006 
                 alpha cardiac muscle 1 os =  homo   
                 P 
                 GO:0009615 
                 response to virus 
               
               
                   
                   sapiens  gn = actc1 pe = 1 sv = 1 
               
               
                 IPI00023006 
                 alpha cardiac muscle 1 os =  homo   
                 P 
                 GO:0060047 
                 heart contraction 
               
               
                   
                   sapiens  gn = actc1 pe = 1 sv = 1 
               
               
                 IPI00023006 
                 alpha cardiac muscle 1 os =  homo   
                 F 
                 GO:0019899 
                 enzyme binding 
               
               
                   
                   sapiens  gn = actc1 pe = 1 sv = 1 
               
               
                 IPI00023006 
                 alpha cardiac muscle 1 os =  homo   
                 C 
                 GO:0016459 
                 myosin complex 
               
               
                   
                   sapiens  gn = actc1 pe = 1 sv = 1 
               
               
                 KH 50 
                 IPI00021841 
                 AFOD 
                 same as 
               
               
                   
                   
                   
                 KH 37 
               
               
                 KH 51 
                 IPI00023006 
                 AlbuRAAS 
                 same as 
               
               
                   
                   
                   
                 KH 49 
               
               
                 KH 52 
                 IPI00930226 
                 FibringluRAAS ® 
                 IPI00930226 
                 cytoplasmic 2 os =  homo    sapiens   
               
               
                   
                   
                 High 
                   
                 gn = actg1 pe = 1 sv = 1 
               
               
                   
                   
                 Concentrate 
               
               
                   
                   
                 Human 
               
               
                   
                   
                 Fibrinogen 
               
               
                 IPI00930226 
                 cytoplasmic 2 os =  homo    sapiens   
                 P 
                 GO:0009888 
                 tissue development 
               
               
                   
                 gn = actg1 pe = 1 sv = 1 
               
               
                 IPI00930226 
                 cytoplasmic 2 os =  homo    sapiens   
                 P 
                 GO:0030048 
                 actin filament-based movement 
               
               
                   
                 gn = actg1 pe = 1 sv = 1 
               
               
                 IPI00930226 
                 cytoplasmic 2 os =  homo    sapiens   
                 P 
                 GO:0003012 
                 muscle system process 
               
               
                   
                 gn = actg1 pe = 1 sv = 1 
               
               
                 IPI00930226 
                 cytoplasmic 2 os =  homo    sapiens   
                 C 
                 GO:0030017 
                 sarcomere 
               
               
                   
                 gn = actg1 pe = 1 sv = 1 
               
               
                 IPI00930226 
                 cytoplasmic 2 os =  homo    sapiens   
                 P 
                 GO:0030239 
                 myofibril assembly 
               
               
                   
                 gn = actg1 pe = 1 sv = 1 
               
               
                 IPI00930226 
                 cytoplasmic 2 os =  homo    sapiens   
                 P 
                 GO:0044278 
                 primary metabolic process 
               
               
                   
                 gn = actg1 pe = 1 sv = 1 
               
               
                 IPI00930226 
                 cytoplasmic 2 os =  homo    sapiens   
                 C 
                 GO:0005884 
                 actin filament 
               
               
                   
                 gn = actg1 pe = 1 sv = 1 
               
               
                 IPI00930226 
                 cytoplasmic 2 os =  homo    sapiens   
                 P 
                 GO:0072358 
                 cardiovascular system 
               
               
                   
                 gn = actg1 pe = 1 sv = 1 
                   
                   
                 development 
               
               
                 IPI00930226 
                 cytoplasmic 2 os =  homo    sapiens   
                 P 
                 GO:0044237 
                 cellular metabolic process 
               
               
                   
                 gn = actg1 pe = 1 sv = 1 
               
               
                 IPI00930226 
                 cytoplasmic 2 os =  homo    sapiens   
                 P 
                 GO:0048513 
                 organ development 
               
               
                   
                 gn = actg1 pe = 1 sv = 1 
               
               
                 IPI00930226 
                 cytoplasmic 2 os =  homo    sapiens   
                 P 
                 GO:0042221 
                 response to chemical stimulus 
               
               
                   
                 gn = actg1 pe = 1 sv = 1 
               
               
                 IPI00930226 
                 cytoplasmic 2 os =  homo    sapiens   
                 F 
                 GO:0008092 
                 cytoskeletal protein binding 
               
               
                   
                 gn = actg1 pe = 1 sv = 1 
               
               
                 IPI00930226 
                 cytoplasmic 2 os =  homo    sapiens   
                 P 
                 GO:0065008 
                 regulation of biological quality 
               
               
                   
                 gn = actg1 pe = 1 sv = 1 
               
               
                 IPI00930226 
                 cytoplasmic 2 os =  homo    sapiens   
                 C 
                 GO:0044451 
                 nucleoplasm part 
               
               
                   
                 gn = actg1 pe = 1 sv = 1 
               
               
                 IPI00930226 
                 cytoplasmic 2 os =  homo    sapiens   
                 P 
                 GO:0008015 
                 blood circulation 
               
               
                   
                 gn = actg1 pe = 1 sv = 1 
               
               
                 IPI00930226 
                 cytoplasmic 2 os =  homo    sapiens   
                 F 
                 GO:0019899 
                 enzyme binding 
               
               
                   
                 gn = actg1 pe = 1 sv = 1 
               
               
                 KH 53 
                 194373497 
                 AFCC 
                 gi|194373497 
                 thrb_humanprothrombin 
               
               
                   
                   
                 (Fraction IV) 
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                   
                   
                   
                 sv = 2 
               
               
                 gi|194373497 
                 thrb_humanprothrombin 
                 C 
                 GO:0044446 
                 intracellular organelle part 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194373497 
                 thrb_humanprothrombin 
                 P 
                 GO:0048712 
                 negative regulation of astrocyte 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
                   
                   
                 differentiation 
               
               
                   
                 sv = 2 
               
               
                 gi|194373497 
                 thrb_humanprothrombin 
                 C 
                 GO:0043233 
                 organelle lumen 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194373497 
                 thrb_humanprothrombin 
                 P 
                 GO:0030194 
                 positive regulation of blood 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
                   
                   
                 coagulation 
               
               
                   
                 sv = 2 
               
               
                 gi|194373497 
                 thrb_humanprothrombin 
                 F 
                 GO:0005102 
                 receptor binding 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194373497 
                 thrb_humanprothrombin 
                 P 
                 GO:2000379 
                 positive regulation of reactive 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
                   
                   
                 oxygen species metabolic 
               
               
                   
                 sv = 2 
                   
                   
                 process 
               
               
                 gi|194373497 
                 thrb_humanprothrombin 
                 P 
                 GO:0045861 
                 negative regulation of proteolysis 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194373497 
                 thrb_humanprothrombin 
                 C 
                 GO:0005615 
                 extracellular space 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194373497 
                 thrb_humanprothrombin 
                 P 
                 GO:0030168 
                 platelet activation 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194373497 
                 thrb_humanprothrombin 
                 P 
                 GO:1900738 
                 positive regulation of 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
                   
                   
                 phospholipase C-activating G- 
               
               
                   
                 sv = 2 
                   
                   
                 protein coupled receptor 
               
               
                   
                   
                   
                   
                 signaling pathway 
               
               
                 gi|194373497 
                 thrb_humanprothrombin 
                 P 
                 GO:0016477 
                 cell migration 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194373497 
                 thrb_humanprothrombin 
                 C 
                 GO:0043231 
                 intracellular membrane-bounded 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
                   
                   
                 organelle 
               
               
                   
                 sv = 2 
               
               
                 gi|194373497 
                 thrb_humanprothrombin 
                 P 
                 GO:0001934 
                 positive regulation of protein 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
                   
                   
                 phosphorylation 
               
               
                   
                 sv = 2 
               
               
                 gi|194373497 
                 thrb_humanprothrombin 
                 C 
                 GO:0005886 
                 plasma membrane 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194373497 
                 thrb_humanprothrombin 
                 F 
                 GO:0070053 
                 thrombospondin receptor activity 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194373497 
                 thrb_humanprothrombin 
                 P 
                 GO:0051281 
                 positive regulation of release of 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
                   
                   
                 sequestered calcium ion into 
               
               
                   
                 sv = 2 
                   
                   
                 cytosol 
               
               
                 gi|194373497 
                 thrb_humanprothrombin 
                 F 
                 GO:0004252 
                 serine-type endopeptidase 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
                   
                   
                 activity 
               
               
                   
                 sv = 2 
               
               
                 gi|194373497 
                 thrb_humanprothrombin 
                 P 
                 GO:0042730 
                 fibrinolysis 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194373497 
                 thrb_humanprothrombin 
                 C 
                 GO:0044444 
                 cytoplasmic part 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
               
               
                   
                 sv = 2 
               
               
                 gi|194373497 
                 thrb_humanprothrombin 
                 P 
                 GO:0032967 
                 positive regulation of collagen 
               
               
                   
                 os =  homo sapiens  gn = f2 pe = 1 
                   
                   
                 biosynthetic process 
               
               
                   
                 sv = 2 
               
               
                 KH 54 
                 194380034 
                 Transferrin 
                 gi|194380034 
                 trfe_humanserotransferrin 
               
               
                   
                   
                   
                   
                 os =  homo sapiens  gn = tf pe = 1 
               
               
                   
                   
                   
                   
                 sv = 3 
               
               
                 gi|194380034 
                 trfe_humanserotransferrin 
                 P 
                 GO:0009987 
                 cellular process 
               
               
                   
                 os =  homo sapiens  gn = tf pe = 1 
               
               
                   
                 sv = 3 
               
               
                 gi|194380034 
                 trfe_humanserotransferrin 
                 P 
                 GO:0065008 
                 regulation of biological quality 
               
               
                   
                 os =  homo sapiens  gn = tf pe = 1 
               
               
                   
                 sv = 3 
               
               
                 gi|194380034 
                 trfe_humanserotransferrin 
                 P 
                 GO:0006810 
                 transport 
               
               
                   
                 os =  homo sapiens  gn = tf pe = 1 
               
               
                   
                 sv = 3 
               
               
                 gi|194380034 
                 trfe_humanserotransferrin 
                 C 
                 GO:0009925 
                 basal plasma membrane 
               
               
                   
                 os =  homo sapiens  gn = tf pe = 1 
               
               
                   
                 sv = 3 
               
               
                 gi|194380034 
                 trfe_humanserotransferrin 
                 C 
                 GO:0005739 
                 mitochondrion 
               
               
                   
                 os =  homo sapiens  gn = tf pe = 1 
               
               
                   
                 sv = 3 
               
               
                 gi|194380034 
                 trfe_humanserotransferrin 
                 C 
                 GO:0030139 
                 endocytic vesicle 
               
               
                   
                 os =  homo sapiens  gn = tf pe = 1 
               
               
                   
                 sv = 3 
               
               
                 gi|194380034 
                 trfe_humanserotransferrin 
                 C 
                 GO:0005905 
                 coated pit 
               
               
                   
                 os =  homo sapiens  gn = tf pe = 1 
               
               
                   
                 sv = 3 
               
               
                 gi|194380034 
                 trfe_humanserotransferrin 
                 C 
                 GO:0005770 
                 late endosome 
               
               
                   
                 os =  homo sapiens  gn = tf pe = 1 
               
               
                   
                 sv = 3 
               
               
                 gi|194380034 
                 trfe_humanserotransferrin 
                 C 
                 GO:0005769 
                 early endosome 
               
               
                   
                 os =  homo sapiens  gn = tf pe = 1 
               
               
                   
                 sv = 3 
               
               
                 gi|194380034 
                 trfe_humanserotransferrin 
                 C 
                 GO:0055037 
                 recycling endosome 
               
               
                   
                 os =  homo sapiens  gn = tf pe = 1 
               
               
                   
                 sv = 3 
               
               
                 gi|194380034 
                 trfe_humanserotransferrin 
                 F 
                 GO:0005515 
                 protein binding 
               
               
                   
                 os =  homo sapiens  gn = tf pe = 1 
               
               
                   
                 sv = 3 
               
               
                 gi|194380034 
                 trfe_humanserotransferrin 
                 C 
                 GO:0048471 
                 perinuclear region of cytoplasm 
               
               
                   
                 os =  homo sapiens  gn = tf pe = 1 
               
               
                   
                 sv = 3 
               
               
                 gi|194380034 
                 trfe_humanserotransferrin 
                 C 
                 GO:0016324 
                 apical plasma membrane 
               
               
                   
                 os =  homo sapiens  gn = tf pe = 1 
               
               
                   
                 sv = 3 
               
               
                 gi|194380034 
                 trfe_humanserotransferrin 
                 P 
                 GO:0006950 
                 response to stress 
               
               
                   
                 os =  homo sapiens  gn = tf pe = 1 
               
               
                   
                 sv = 3 
               
               
                 KH 55 
                 194380034 
                 Transferrin 
                 same as 
               
               
                   
                   
                   
                 KH 54 
               
               
                   
               
             
          
         
       
     
         [0021]    Additional protein sequence information as well as sequence identifiers and accession numbers for KH proteins 1-55 are found in the table below. 
         [0000]    
       
         
               
               
               
             
               
               
               
               
             
           
               
                   
               
               
                 KH 
                   
                   
               
               
                 Protein/ 
                 Sequence 
                   
               
               
                 SEQ ID NO 
                 Identifier(s) 
                 Protein Sequence 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                 1 
                 gi:21749960 
                 MDTYIESHFA GALAYRDLIK VLKWYVDRIT EAERQEHIQE VLKAQEYIFK YIVQSRRLFS 
                 60 
               
               
                   
                 BAC03696.1 
                 LATGGQNEEE FRCCIQELLM SVRFFLSQES KGSGALSQSQ AVFLSSFPAV YSELLKLFDV 
                 120 
               
               
                   
                   
                 REVANLVQDT LGSLPTILHV DDSLQAIKLQ CIGKTVESQL YTNPDSRYIL LPVVLHHLHI 
                 180 
               
               
                   
                   
                 HLQEQKDLIM CARILSNVFC LIKKNSSEKS VLEEIDVIVA SLLDILLRTI LEITSRPQPS 
                 240 
               
               
                   
                   
                 SSAMRFQFQD VTGEFVACLL SLLRQMTDRH YQQLLDSFNT KEELRDFLLQ IFTVFRILIR 
                 300 
               
               
                   
                   
                 PEMFPKDWTV MRLVANNVII TTVLYLSDAL RKNFLNENFD YKIWDSYFYL AVIFINQLCL 
                 360 
               
               
                   
                   
                 QLEMFTPSKK KKVLEKYGDM RVTMGCEIFS MWQNLGEHKL HFIPALIGPF LEVTLIPQPD 
                 420 
               
               
                   
                   
                 LRNVMIPIFH DMMDWEQRRS GNFKQVEAKL IDKLDSLMSE GEGDETYREL FNSIIPLFGP 
                 480 
               
               
                   
                   
                 YPSLLKKIER ETWRESGVSL IATVTRLMER LLDYRDCMKM GEVDGKKIGC TVSLLNFYKT 
                 540 
               
               
                   
                   
                 ELNKEEMYIR YIHKLYDLHL KAQNFTEAAY TLLLYDELLE WSDRPLREFL TYPMQTEWQR 
                 600 
               
               
                   
                   
                 KEHLHLTIIQ NFDRGKCWEN GIILCRKIAE QYESYYDYRN LSKMRMMEAS LYDKIMDQQR 
                 660 
               
               
                   
                   
                 LEPEFFRVGF YGKKFPFFLR NKEFVCRGHD YERLEAFQQR MLNEFPHAIA MQHANQPDET 
                 720 
               
               
                   
                   
                 IFQAEAQYLQ IYAVTPIPES QEVLQREGVP DNIKSFYKVN HIWKFRYDRP FHKGT 
                 775 
               
               
                   
               
               
                 2 
                 gi:215415640 
                 DEPPQSPWDR VKDLATVYVD VLKDSGRDYV SQFEGSALGK QLNLKLLDNW DSVTSTFSKL 
                 60 
               
               
                   
                 CAT02162.1 
                 REQLGPVTQE FWDNLEKETE GLRQEMSKDL EEVKAKVQPY LDDFQKKWQE EMELYRQKVE 
                 120 
               
               
                   
                   
                 PLRAELQEGA RQKLHELQEK LSPLGEEMRD CARAHVDALR THLAPYSDEL RQRLAARLEA 
                 180 
               
               
                   
                   
                 LKENGGARLA EYHAKATEHL STLSEKAKPA LEDLRQGLLP VLESFKVSFL SALEEYTKKL 
                 240 
               
               
                   
                   
                 N 
                 241 
               
               
                   
               
               
                 3 
                 gi:215415638 
                 DEPPQSPWDR VKDLATVYVD VLKDSGRDYV SQFEGSALGK QLNLKLLDNW DSVTSTFSKL 
                 60 
               
               
                   
                 CAT02161.1 
                 REQLGPVTQE FWDNLEKETE GLCQEMSKDL EEVKAKVQPY LDDFQKKWQE EMELYRQKVE 
                 120 
               
               
                   
                   
                 PLRAELQEGA RQKLHELQEK LSPLGEEMRD RARAHVDALR THLAPYSDEL RQRLAARLEA 
                 180 
               
               
                   
                   
                 LKENGGARLA EYHAKATEHL STLSEKAKPA LEDLRQGLLP VLESFKVSFL SALEEYTKKL 
                 240 
               
               
                   
                   
                 NTQ 
                 243 
               
               
                   
               
               
                 4 
                 gi:40044478 
                 MGCKRASEVC GXAVEGLRDP LKPSEPSQGA AGKRKGTEYL MKQKLEFGGR GEELLLGVHL 
                 60 
               
               
                   
                 CAF01015.1 
                 RGAQKTGGGW RR 
                 72 
               
               
                   
               
               
                 5 
                 gi:194383496 
                 TATDVFWAKY TACETARTPR DKLAACLEGN CAEGLGTNYR GHVNITRSGI ECQLWRSRYP 
                 120 
               
               
                   
                 BAG64719.1 
                 HKPEINSTTH PGADLQENFC RNPDSSTTGP WCYTTDPTVR RQECSIPVCG QDQVTVAMTP 
                 180 
               
               
                   
                   
                 RSEGSSVNLS PPLEQCVPDR GQQYQGRLAV TTHGLPCLAW ASAQAKALSK HQDFNSAVQL 
                 240 
               
               
                   
                   
                 VENFCRNPDG DEEGVWCYVA GKPGDFGYCD LNYCEEAVEE ETGDGLDEDS DRAIEGRTAT 
                 300 
               
               
                   
                   
                 SEYQTFFNPR TFGSGEADCG LRPLFEKKSL EDKTERELLE SYIDGRIVEG SDAEIGMSPW 
                 360 
               
               
                   
                   
                 QVMLFRKSPQ ELLCGASLIS DRWVLTAAHC LLYPPWDKNF TENDLLVRIG KHSRTRYERN 
                 420 
               
               
                   
                   
                 IEKISMLEKI YIHPRYNWRE NLDRDIALMK LKKPVAFSDY IHPVCLPDRE TAASLLQAGY 
                 480 
               
               
                   
                   
                 KGRVTGWGNL KETWTANVGK GQPSVLQVVN LPIVERPVCK DSTRIRITDN MFCAGYKPDE 
                 540 
               
               
                   
                   
                 GKRGDACEGD SGGPFVMKSP FNNRWYQMGI VSWGEGCDRD GKYGFYTHVF RLKKWIQKVI 
                 600 
               
               
                   
                   
                 DQFGE 
                 605 
               
               
                   
               
               
                 6 
                 gi:28071026 
                 MQGTDEHVVC KVQHPNGNKE KNVPLPVIAE LPPKVSVFVP PRDGFFGNPR KSKLICQATG 
                 60 
               
               
                   
                 CAD61894.1 
                 FSPRQIQVSW LREGKQVGSG VTTDQVQAEA KESGPTTYKV TSTLTIKESD WLSQSMFTCR 
                 120 
               
               
                   
                   
                 VDHRGLTFQQ NASSMCGPDQ DTAIRVFAIP PSFASIFLTK STKLTCLVTD LTTYDSVTIS 
                 180 
               
               
                   
                   
                 WTRQNGEAVK THTNISESHP NATFSAVGEA SICEDDWNSG ERFTCTVTHT DLPSPLKQTI 
                 240 
               
               
                   
                   
                 SRPKGVALHR PDVYLLPPAR EQLNLRESAT ITCLVTGFSP ADVFVQWMQR GQPLSPEKYV 
                 300 
               
               
                   
                   
                 TSAPMPEPQA PGRYFAHSIL TVSEEEWNTG ETYTCVVAHE ALPNRVTERT VDKSTGKPTL 
                 360 
               
               
                   
                   
                 YNVSLVMSDT AGTCY 
                 375 
               
               
                   
               
               
                 7 
                 gi:300621695 
                 MEFGLSWLFL VAILKGVQCE VQLLESGGGL VQPGGSLRLS CAASGFTFSS YAMSWVRQAP 
                 60 
               
               
                   
                 CBU30464.1 
                 GKGLEWVSAI SGSGYTTYYA DSVKGRFTIS RDNSKNTLY QMNSLRAEDT AVYYCAKKPG 
                 120 
               
               
                   
                   
                 DYGSGSYYLD YWGQGTLVTV SSGSASAPTL FPLVSCENSP SDTSSVAVGC LAQDFLPDSI 
                 180 
               
               
                   
                   
                 TFSWKYKNNS DISSTRGFPS VLRGGKYAAT SQVLLPSKDV MQGTDEHVVC KVQHPNGNKE 
                 240 
               
               
                   
                   
                 KNVPLPVIAE LPPKVSVFVP PRDGFFGNPR KSKLICQATG FSPRQIQVSW LREGKQVGSG 
                 300 
               
               
                   
                   
                 VTTDQVQAEA KESGPTTYKV TSTLTIKESD WLSQSMFTCR VDHRGLTFQQ NASSMCVPDQ 
                 360 
               
               
                   
                   
                 DTAIRVFAIP PSFASIFLTK STKLTCLVTD LTTYDSVTIS WTRQNGEAVK THTNISESHP 
                 420 
               
               
                   
                   
                 NATFSAVGEA SICEDDWNSG ERFTCTVTHT DLPSPLKQTI SRPKGVALHR PDVYLLPPAR 
                 480 
               
               
                   
                   
                 EQLNLRESAT ITCLVTGFSP ADVFVQWMQR GQPLSPEKYV TSAPMPEPQA PGRYFAHSIL 
                 540 
               
               
                   
                   
                 TVSEEEWNTG ETYTCVVAHE ALPNRVTERT VDKSTGKPTL YNVSLVMSDT AGTCY 
                 595 
               
               
                   
               
               
                 8 
                 gi:1335098 
                 TPLPPTSAHG NVAEGETKPD PDVTERCSDG WSFDATTLDD NGTMLFFKGE FVWKSHKWDR 
                 60 
               
               
                   
                 CAA26382.1 
                 ELISERWKNF PSPVDAAFRQ GHNSVFLIKG DKVWVYPPEK KEKGYPKLLQ DEFPGIPSPL 
                 120 
               
               
                   
                   
                 DAAVECHRGE CQAEGVLFFQ GDREWFWDLA TGTMKERSWP AVGNCSSALR WLGRYYCFQG 
                 180 
               
               
                   
                   
                 NQFLRFDPVR GEVPPRYPRD VRDYFMPCPG RGHGHRNGTG HGNSTHHGPE YMRCSPHLVL 
                 240 
               
               
                   
                   
                 SALTSDNHGA TYAFSGTHYW RLDTSRDGWH SWPIAHQWPQ GPSAVDAAFS WEEKLYLVQG 
                 300 
               
               
                   
                   
                 TQVYVFLTKG GYTLVSGYPK RLEKEVGTPH GIILDSVDAA FICPGSSRLH IMAGRRLWWL 
                 360 
               
               
                   
                   
                 DLKSGAQATW TELPWPHEKV DGALCMEKSL GPNSCSANGP GLYLIHGPNL YCYSDVEKLN 
                 420 
               
               
                   
                   
                 AAKALPQPQN VTSLLGCTH 
                 439 
               
               
                   
               
               
                 9 
                 gi:10434804 
                 MEPRAVGVSK QDIREQIWGY MESQNLADFP RPVHHRIPNF KGSYLACQNI KDLDVFARAQ 
                 60 
               
               
                   
                 BAB14383.1 
                 EVKVDPDKPL EGVRLLVLQS KKTLLVPTPR LRTGLFNKIT PPPGATKDIL RKCATSQGVR 
                 120 
               
               
                   
                   
                 NYSVPIGLDS RVLVDLVVVG SVAASEKGWR IGKGEGYADL EYAMMVSMGA VSKETPVVTI 
                 180 
               
               
                   
                   
                 VHDCQVVDIP EELVEEHDIT VDYILTPTRV IATGCKRPKP MGITWFKISL EMMEKIPILR 
                 240 
               
               
                   
                   
                 SLRAREQQAG KDVTLQGEHQ HLPEPGCQQT VPLSVGRRPP DTPGPETNSM EAAPGSPPGE 
                 300 
               
               
                   
                   
                 GAPLAADVYV GNLPRDARVS DLKRALRELG SVPLRLTWQG PRRRAFLHYP DSAAASRPSP 
                 360 
               
               
                   
                   
                 ACRACAWAPT P 
                 371 
               
               
                   
               
               
                 10 
                 gi:221044726 
                 MARVLGAPVA LGLWSLCWSL AIATPLPPTS AHGNVAEGET KPDPDVTERC SDGWSFDATT 
                 60 
               
               
                   
                 BAH14040.1 
                 LDDNGTMLFF KGEFVWKSHK WDRELISERL KNFPSPVDAA FRQGHNSVFL IKVLLGQNQG 
                 120 
               
               
                   
                   
                 QAGKGWNRHW GPFPQMALAW SP 
                 142 
               
               
                   
               
               
                 11 
                 gi:215415638 
                 Same as KH3 
                   
               
               
                   
                 CAT02161.1 
                   
                   
               
               
                   
               
               
                 12 
                 gi:189066554 
                 MAHVRGLQLP GCLALAALCS LVHSQHVFLA PQQARSLLQR VRRANTFLEE VRKGNLEREC 
                 60 
               
               
                   
                 BAG35804.1 
                 VEETCSYEEA FEALESSTAT DVFWAKYTAC ETARTPRDKL AACLEGNCAE GLGTNYRGHV 
                 120 
               
               
                   
                   
                 NITRSGIECQ LWRSRYPHKP EINSTTHPGA DLQENFCRNP DSSTMGPWCY TTDPTVRRQE 
                 180 
               
               
                   
                   
                 CSIPVCGQDQ VTVAMTPRSE GSSVNLSPPL EQCVPDRGQQ YQGRLAVTTH GLPCLAWASA 
                 240 
               
               
                   
                   
                 QAKALSKHQD FNSAVQLVEN FCRNPDGDEE GVWCYVAGKP GDFGYCDLNY CEEAVEEETG 
                 300 
               
               
                   
                   
                 DGLDEDSDRA IEGRTATSEY QTFFNPRTFG SGEADCGLRP LFEKKSLEDK TERELLESYI 
                 360 
               
               
                   
                   
                 DGRIVEGSDA EIGMSPWQVM LFRKSPQELL CGASLISDRW VLTAAHCLLY PPWDKNFTEN 
                 420 
               
               
                   
                   
                 DLLVRIGKHS RTRYERNIEK ISMLEKIYIH PRYNWRENLD RDIALMKLKK PVAFSDYIHP 
                 480 
               
               
                   
                   
                 VCLPDRETAA SLLQAGYKGR VTGWGNLKET WTANVGKGQP SVLQVVNLPI VERPVCKDST 
                 540 
               
               
                   
                   
                 RIRITDNMFC AGYKPDEGKR GDACEGDSGG PFVMKSPFNN RWYQMGIVSW GEGCDRDGKY 
                 600 
               
               
                   
                   
                 GFYTHVFRLK KWIQKVIDQF GE 
                 622 
               
               
                   
               
               
                 13 
                 gi:194391084 
                 MKLSLTQESQ SEEIDCNDKD LFKAVDAALK KYNSQNQSNN QFVLYRITEA TKTVGSDTFY 
                 60 
               
               
                   
                 BAG60660.1 
                 SFKYEIKEGD CPVQSGKTWQ DCEYKDAAKA ATGECTATVG KRSSTKFSVA TQTCQITPAE 
                 120 
               
               
                   
                   
                 GPVVTAQYDC LGCVHPISTQ SPDLEPILRH GIQYFNNNTQ HSSLFMLNEV KRAQRQVVAG 
                 180 
               
               
                   
                   
                 LNFRITYSIV QTNCSKENFL FLTPDCKSLW NGDTGECTDN AYIDIQLRIA SFSQNCDIYP 
                 240 
               
               
                   
                   
                 GKDFVQPPTK ICVGCPRDIP TNSPELEETL THTITKLNAE NNATFYFKID NVKKARVQVV 
                 300 
               
               
                   
                   
                 AGKKYFIDFV ARETTCSKES NEELTESCET KKLGQSLDCN AEVYVVPWEK KIYPTVNCQP 
                 360 
               
               
                   
                   
                 LGMISLMKRP PGFSPFRSSR IGEIKEETTS HLRSCEYKGR PPKAGAEPAS EREVS 
                 415 
               
               
                   
               
               
                 14 
                 gi:158255114 
                 MKLITILFLC SRLLLSLTQE SQSEEIDCND KDFFKAVDAA LKKYNSQNQS NNQFVLYRIT 
                 60 
               
               
                   
                 BAF83528.1 
                 EATKTVGSDT FYSFKYEIKE GDCPVQSGKT WQDCEYKDAA KAATGECTAT VGKRSSTKFS 
                 120 
               
               
                   
                   
                 VATQTCQITP AEGPVVTAQY DCLGCVHPIS TQSPDLEPIL RHGIQYFNNN TQHSSLFMLN 
                 180 
               
               
                   
                   
                 EVKRAQRQVV AGLNFRITYS IVQTNCSKEN FLFLTPDCKS LWNGDTGECT DNAYIDIQLR 
                 240 
               
               
                   
                   
                 IASFSQNCDI YPGKDFVQPP TKICVGCPRD IPTNSPELEE TLTHTITKLN AENNATFYFK 
                 300 
               
               
                   
                   
                 IDNVKKARVQ AVAGKKYFID FVARETTCSK ESNEELTESC ETKKLGQSLD CNAEVYVVPW 
                 360 
               
               
                   
                   
                 EKKIYPTVNC QPLGMISLMK RPPGFSPFRS SRIGEIKEET TSHLRSCEYK GRPPKAGAEP 
                 420 
               
               
                   
                   
                 ASEREVS 
                 427 
               
               
                   
               
               
                 15 
                 gi:213506121 
                 MKLITILFLC SRLLLSLTQE SQSEEIDCND KDLFKAVDAA LKKYNSQNQS NNQFVLYRIT 
                 60 
               
               
                   
                 CA591511.1 
                 EATKTVGSDT FYSFKYEIKE GDCPVQSGKT WQDCEYKDAA KAATGECTAT VGKRSSTKFS 
                 120 
               
               
                   
                   
                 VATQTCQITP AEGPVVTAQY DCLGCVHPIS TQSPDLEPIL RHGIQYFNNN TQHSSLFMLN 
                 180 
               
               
                   
                   
                 EVKRAQRQVV AGLNFRMTYS IVQTNCSKEN FLFLTPDCKS LWNGDTGECT DNAYIDIQLR 
                 240 
               
               
                   
                   
                 IASFSQNCDI YPGKDFVQPP TKICVGCPRD IPTNSPELEE TLTHTITKLN AENNATFYFK 
                 300 
               
               
                   
                   
                 IDNVKKARVQ VVAGKKYFID FVARETTCSK ESNEELTESC ETKKLGQSLD CNAEVYVVPW 
                 360 
               
               
                   
                   
                 EKKIYPTVNC QPLGMISLMK RPPGFSPFRS SRIGEIKEET TSHLRSCEYK GRPPKAGAEP 
                 420 
               
               
                   
                   
                 ASEREVS 
                 427 
               
               
                   
               
               
                 16 
                 gi:213506103 
                 MKLITILFLC SRLLLSLTQE SQSEEIDCND KDLFKAVDAA LKKYNSQNQS NNQFVLYRIT 
                 60 
               
               
                   
                 CAS91502.1 
                 EATKTVGSDT FYSFKYEIKE GDCPVQSGKT WQDCEYKDAA KAATGECTAT VGKRSSTKFS 
                 120 
               
               
                   
                   
                 VATQTCQITP AEGPVVTAQY DCLGCVHPIS TQSPDLEPIL RHGIQYFNNN TQHSSLFMLN 
                 180 
               
               
                   
                   
                 EVKRAQRQVV AGLNFRMTYS IVQTNCSKEN FLFLTPDCKS LWNGDTGECT DNAYIDIQLR 
                 240 
               
               
                   
                   
                 IASFSQNCDI YPGKDFVQPP TKICVGCPRD IPTNSPELEE TLTHTITKLN AENNATFYFK 
                 300 
               
               
                   
                   
                 IDNVKKARVQ VVAGKKYFID FVARETTCSK ESNEELTESC ETKKLGQSLD CNAEVYVVPW 
                 360 
               
               
                   
                   
                 EKKIYPTVNC QPLGMISLMK RPPGFSPFRS SRIGEIKEET TSHLRSCEYK GRPPKAGAEP 
                 420 
               
               
                   
                   
                 ASEREVS 
                 427 
               
               
                   
               
               
                 17 
                 gi:194376310 
                 MDDDIAALVV DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGVMVGIVTN WDDMEKIWHH 
                 60 
               
               
                   
                 BAG62914.1 
                 TFYNELRVAP EEHPVLLTEA PLNPKANREK MTQIMFETFN TPAMYVAIQA VLSLYASGRT 
                 120 
               
               
                   
                   
                 TGIVMDSGDG VTHTVPIYEG YALPHAILRL DLAGRDLTDY LMKILTERGY SFTTTAEREI 
                 180 
               
               
                   
                   
                 VRDIKEKLCY VALDFEQEMA TAASSSSLEK SYELPDGQVI TIGNERFRCP EALFQPSFLG 
                 240 
               
               
                   
                   
                 MESCGIHETT FNSIMKCDVD IRKDLYANTV LSGGTTMYPG IADRMQKEIT ALAPSTMKIK 
                 300 
               
               
                   
                   
                 IIAPPERKYS VWIGGSILAS LSTFQQMWIS KQEYDESGPS IVHRKCF 
                 347 
               
               
                   
               
               
                 18 
                 gi:194388064 
                 MEEEIAALVI DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGVMVGMGQK DSYVGDEAQS 
                 60 
               
               
                   
                 BAG65416.1 
                 KRGILTLKYP IEHGIVTNWD DMEKIWHHTF YNELRVAPEE HPVLLTEAPL NPKANREKMT 
                 120 
               
               
                   
                   
                 QIMFETFNTT GIVMDSGDGV THTVPIYEGY ALPHAILRLD LAGRDLTDYL MKILTERGYS 
                 180 
               
               
                   
                   
                 FTTTAEREIV RDIKEKLCYV ALDFEQEMAT AASSSSLEKS YELPDGQVIT IGNERFRCPE 
                 240 
               
               
                   
                   
                 ALFQPSFLGM ESCGIHETT NSIMKCDVDI RKDLYANTVL SGGTTMYPGI ADRMQKEITA 
                 300 
               
               
                   
                   
                 LAPSTMKIKI IAPPERKYSV WIGGSILASL STFQQMWISK QEYDESGPSI VHRKCF 
                 356 
               
               
                   
               
               
                 19 
                 IPI00964149 
                 MQKSEGSGGT QLKNRATGNY DQRTSSSTQL KHRNAVQGSK SSLSTSSPES ARKLHPRPSD 
                 60 
               
               
                   
                 gi:126215685 
                 KLNPKTINPF GEQSRVPSAF AAIYSKGGIP CRLVHGSVKH RLQWECPPES LSFDPLLITL 
                 120 
               
               
                   
                 Q8N7B6.2 
                 AEGLRETKHP YTFVSKEGFR ELLLVKGAPE KAIPLLPRLI PVLKAALVHS DDEVFERGLN 
                 180 
               
               
                   
                   
                 ALVQLSVVVG PSLNDHLKHL LTSLSKRLMD KKFKEPITSA LQKLEQHGGS GSLSIIKSKI 
                 240 
               
               
                   
                   
                 PTYCSICC 
                 248 
               
               
                   
               
               
                 20 
                 IPI00966721 
                 MASETEKTHA LLQTCSTESL ISSLGLGAFC LVADRLLQFS TIQQNDWLRA LSDNAVHCVI 
                 60 
               
               
                   
                 gi:121940485 
                 GMWSWAVVTG IKKKTDFGEI ILAGFLASVI DVDHFFLAGS MSLKAALTLP RRPFLHCSTV 
                 120 
               
               
                   
                 Q0VDI3.1 
                 IPVVVLTLKF TMHLFKLKDS WCFLPWMLFI SWTSHHIRDG IRHGLWICPF GKTSPLPFWL 
                 180 
               
               
                   
                   
                 YVIITSSLPH ICSFVMYLTG TRQMMSSKHG VRIDV 
                 215 
               
               
                   
               
               
                 21 
                 IPI00966826 
                 MDFTAQPKPA TALCGVVSAD GKIAYPPGVK EITDKITTDE MIKRLKMVVK TFMDMDQDSE 
                 60 
               
               
                   
                 gi:121947590 
                 DEKQQYLPLA LHLASEFFLR NPNKDVRLLV ACCLADIFRI YAPEAPYTSH DKLKDIFLFI 
                   
               
               
                   
                 Q29RF7.1 
                 TRQLKGLEDT KSPQFNRYFY LLENLAWVKS YNICFELEDC NEIFIQLFRT LFSVINNSHN 
                 180 
               
               
                   
                   
                 KKVQMHMLDL MSSIIMEGDG VTQELLDSIL INLIPAHKNL NKQSFDLAKV LLKRTVQTIE 
                 240 
               
               
                   
                   
                 ACIANFFNQV LVLGRSSVSD LSEHVFDLIQ ELFAIDPHLL LSVMPQLEFK LKSNDGEERL 
                 300 
               
               
                   
                   
                 AVVRLLAKLF GSKDSDLATQ NRPLWQCFLG RFNDIHVPVR LESVKFASHC LMNHPDLAKD 
                 360 
               
               
                   
                   
                 LTEYLKVRSH DPEEAIRHDV IVTIITAAKR DLALVNDQLL GFVRERTLDK RWRVRKEAMM 
                 420 
               
               
                   
                   
                 GLAQLYKKYC LHGEAGKEAA EKVSWIKDKL LHIYYQNSID DKLLVEKIFA QYLVPHNLET 
                 480 
               
               
                   
                   
                 EERMKCLYYL YASLDPNAVK ALNEMWKCQN MLRSHVRELL DLHKQPTSEA NCSAMFGKLM 
                 540 
               
               
                   
                   
                 TIAKNLPDPG KAQDFVKKFN QVLGDDEKLR SQLELLISPT CSCKQADICV REIARKLANP 
                 600 
               
               
                   
                   
                 KQPTNPFLEM VKFLLERIAP VHIDSEAISA LVKLMNKSIE GTADDEEEGV SPDTAIRSGL 
                 660 
               
               
                   
                   
                 ELLKVLSFTH PTSFHSAETY ESLLQCLRME DDKVAEAAIQ IFRNTGHKIE TDLPQIRSTL 
                 720 
               
               
                   
                   
                 IPILHQKAKR GTPHQAKQAV HCIHAIFTNK EVQLAQIFEP LSRSLNADVP EQLITPLVSL 
                 780 
               
               
                   
                   
                 GHISMLAPDQ FASPMKSVVA NFIVKDLLMN DRSTGEKNGK LWSPDEEVSP EVLAKVQAIK 
                 840 
               
               
                   
                   
                 LLVRWLLGMK NNQSKSANST LRLLSAMLVS EGDLTEQKRI SKSDMSRLRL AAGSAIMKLA 
                 900 
               
               
                   
                   
                 QEPCYHEIIT PEQFQLCALV INDECYQVRQ IFAQKLHKAL VKLLLPLEYM AIFALCAKDP 
                 960 
               
               
                   
                   
                 VKERRAHARQ CLLKNISIRR EYIKQNPMAT EKLLSLLPEY VVPYMIHLLA HDPDFTRSQD 
                 1020 
               
               
                   
                   
                 VDQLRDIKEC LWFMLEVLMT KNENNSHAFM KKMAENIKLT RDAQSPDESK TNEKLYTVCD 
                 1080 
               
               
                   
                   
                 VALCVINSKS ALCNADSPKD PVLPMKFFTQ PEKDFCNDKS YISEETRVLL LTGKPKPAGV 
                 1140 
               
               
                   
                   
                 LGAVNKPLSA TGRKPYVRST GTETGSNINV NSELNPSTGN RSREQSSEAA ETGVSENEEN 
                 1200 
               
               
                   
                   
                 PVRIISVTPV KNIDPVKNKE INSDQATQGN ISSDRGKKRT VTAAGAENIQ QKTDEKVDES 
                 1260 
               
               
                   
                   
                 GPPAPSKPRR GRRPKSESQG NATKNDDLNK PINKGRKRAA VGQESPGGLE AGNAKAPKLQ 
                 1320 
               
               
                   
                   
                 DLAKKAAPAE RQIDLQR 
                 1337 
               
               
                   
               
               
                 22 
                 IPI00760788 
                 MAEEQEFTQL CKLPAQPSHP HCVNNTYRSA QHSQALLRGL LALRDSGILF DVVLVVEGRH 
                 60 
               
               
                   
                 gi:109892504 
                 IEAHRILLAA SCDYFRGMFA GGLKEMEQEE VLIHGVSYNA MCQILHFIYT SELELSLSNV 
                 120 
               
               
                   
                 Q53GT1.2 
                 QETLVAACQL QIPEIIHFCC DFLMSWVDEE NILDVYRLAE LFDLSRLTEQ LDTYILKNFV 
                 180 
               
               
                   
                   
                 AFSRTDKYRQ LPLEKVYSLL SSNRLEVSCE TEVYEGALLY HYSLEQVQAD QISLHEPPKL 
                 240 
               
               
                   
                   
                 LETVRFPLME AEVLQRLHDK LDPSPLRDTV ASALMYHRNE SLQPSLQSPQ TELRSDFQCV 
                 300 
               
               
                   
                   
                 VGFGGIHSTP STVLSDQAKY LNPLLGEWKH FTASLAPRMS NQGIAVLNNF VYLIGGDNNV 
                 360 
               
               
                   
                   
                 QGFRAESRCW RYDPRHNRWF QIQSLQQEHA DLSVCVVGRY IYAVAGRDYH NDLNAVERYD 
                 420 
               
               
                   
                   
                 PATNSWAYVA PLKREVYAHA GATLEGKMYI TCGRRGEDYL KETHCYDPGS NTWHTLADGP 
                 480 
               
               
                   
                   
                 VRRAWHGMAT LLNKLYVIGG SNNDAGYRRD VHQVACYSCT SGQWSSVCPL PAGHGEPGIA 
                 540 
               
               
                   
                   
                 VLDNRIYVLG GRSHNRGSRT GYVHIYDVEK DCWEEGPQLD NSISGLAACV LTLPRSLLLE 
                 600 
               
               
                   
                   
                 PPRGTPDRSQ ADPDFASEVM SVSDWEEFDN SSED 
                 634 
               
               
                   
               
               
                 23 
                 IPI00917278 
                 MKQLQPQPPP KMGDFYDPEH PTPEEEENEA KIENVQKTGF IKGPMFKGVA SSRFLPKGTK 
                 60 
               
               
                   
                 gi: 
                 TKVNLEEQGR QKVSFSFSLT KKTLQNRFLT ALGNEKQSDT PNPPAVPLQV DSTPKMKMEI 
                 120 
               
               
                   
                   
                 GDTLSTAEES SPPKSRVELG KIHFKKHLLH VTSRPLLATT TAVASPPTHA APLPAVIAES 
                 180 
               
               
                   
                   
                 TTVDSPPSSP PPPPPPAQAT TLSSPAPVTE PVALPHTPIT VLMAAPVPLP VDVAVRSLKE 
                 240 
               
               
                   
                   
                 PPIIIVPESL EADTKQDTIS NSLEEHVTQI LNEQADISSK KEDSHIGKDE EIPDSSKISL 
                 300 
               
               
                   
                   
                 SCKKTGSKKK SSQSEGIFLG SESDEDSVRT SSSQRSHDLK FSASIEKERD FKKSSAPLKS 
                 360 
               
               
                   
                   
                 EDLGKPSRSK TDRDDKYFSY SKLERDTRYV SSRCRSERER RRSRSHSRSE RGSRTNLSYS 
                 420 
               
               
                   
                   
                 RSERSHYYDS DRRYHRSSPY RERTRYSRPY TDNRARESSD SEEEYKKTYS RRTSSHSSSY 
                 480 
               
               
                   
                   
                 RDLRTSSYSK SDRDCKTETS YLEMERRGKY SSKLERESKR TSENEAIKRC CSPPNELGFR 
                 540 
               
               
                   
                   
                 RGSSYSKHDS SASRYKSTLS KPIPKSDKFK NSFCCTELNE EIKQSHSFSL QTPCSKGSEL 
                 600 
               
               
                   
                   
                 RMINKNPERE KAGSPAPSNR LNDSPTLKKL DELPIFKSEF ITHDSHDSIK ELDSLSKVKN 
                 660 
               
               
                   
                   
                 DQLRSFCPIE LNINGSPGAE SDLATFCTSK TDAVLMTSDD SVTGSELSPL VKACMLSSNG 
                 720 
               
               
                   
                   
                 FQNISRCKEK DLDDTCMLHK KSESPFRETE PLVSPHQDKL MSMPVMTVDY SKTVVKEPVD 
                 780 
               
               
                   
                   
                 TRVSCCKTKD SDIYCTLNDS NPSLCNSEAE NIEPSVMKIS SNSFMNVHLE SKPVICDSRN 
                 840 
               
               
                   
                   
                 LTDHSKFACE EYKQSIGSTS SASVNHFDDL YQPIGSSGIA SSLQSLPPGI KVDSLTLLKC 
                 900 
               
               
                   
                   
                 GENTSPVLDA VLKSKKSSEF LKHAGKETIV EVGSDLPDSG KGFASRENRR NNGLSGKCLQ 
                 960 
               
               
                   
                   
                 EAQEEGNSIL PERRGRPEIS LDERGEGGHV HTSDDSEVVF SSCDLNLTME DSDGVTYALK 
                 1020 
               
               
                   
                   
                 CDSSGHAPEI VSTVHEDYSG SSESSNDESD SEDTDSDDSS IPRNRLQSVV VVPKNSTLPM 
                 1080 
               
               
                   
                   
                 EETSPCSSRS SQSYRHYSDH WEDERLESRR HLYEEKFESI ASKACPQTDK FFLHKGTEKN 
                 1140 
               
               
                   
                   
                 PEISFTQSSR KQIDNRLPEL SHPQSDGVDS TSHTDVKSDP LGHPNSEETV KAKIPSRQQE 
                 1200 
               
               
                   
                   
                 ELPIYSSDFE DVPNKSWQQT TFQNRPDSRL GKTELSFSSS CEIPHVDGLH SSEELRNLGW 
                 1260 
               
               
                   
                   
                 DFSQEKPSTT YQQPDSSYGA CGGHKYQQNA EQYGGTRDYW QGNGYWDPRS GRPPGTGVVY 
                 1320 
               
               
                   
                   
                 DRTQGQVPDS LTDDREEEEN WDQQDGSHFS DQSDKFLLSL QKDKGSVQAP EISSNSIKDT 
                 1380 
               
               
                   
                   
                 LAVNEKKDFS KNLEKNDIKD RGPLKKRRQE IESDSESDGE LQDRKKVRVE VEQGETSVPP 
                 1440 
               
               
                   
                   
                 GSALVGPSCV MDDFRDPQRW KECAKQGKMP CYFDLIEENV YLTERKKNKS HRDIKRMQCE 
                 1500 
               
               
                   
                   
                 CTPLSKDERA QGEIACGEDC LNRLLMIECS SRCPNGDYCS NRRFQRKQHA DVEVILTEKK 
                 1560 
               
               
                   
                   
                 GWGLRAAKDL PSNTFVLEYC GEVLDHKEFK ARVKEYARNK NIHYYFMALK NDEIIDATQK 
                 1620 
               
               
                   
                   
                 GNCSRFMNHS CEPNCETQKW TVNGQLRVGF FTTKLVPSGS ELTFDYQFQR YGKEAQKCFC 
                 1680 
               
               
                   
                   
                 GSANCRGYLG GENRVSIRAA GGKMKKERSR KKDSVDGELE ALMENGEGLS DKNQVLSLSR 
                 1740 
               
               
                   
                   
                 LMVRIETLEQ KLTCLELIQN THSQSCLKSF LERHGLSLLW IWMAELGDGR ESNQKLQEEI 
                 1800 
               
               
                   
                   
                 IKTLEHLPIP TKNMLEESKV LPIIQRWSQT KTAVPPLSEG DGYSSENTSR AHTPLNTPDP 
                 1860 
               
               
                   
                   
                 STKLSTEADT DTPKKLMFRR LKIISENSMD SAISDATSEL EGKDGKEDLD QLENVPVEEE 
                 1920 
               
               
                   
                   
                 EELQSQQLLP QQLPECKVDS ETNIEASKLP TSEPEADAEI EPKESNGTKL EEPINEETPS 
                 1980 
               
               
                   
                   
                 QDEEEGVSDV ESERSQEQPD KTVDISDLAT KLLDSWKDLK EVYRIPKKSQ TEKENTTTER 
                 2040 
               
               
                   
                   
                 GRDAVGFRDQ TPAPKTPNRS RERDPDKQTQ NKEKRKRRSS LSPPSSAYER GTKRPDDRYD 
                 2100 
               
               
                   
                   
                 TPTSKKKVRI KDRNKLSTEE RRKLFEQEVA QREAQKQQQQ MQNLGMTSPL PYDSLGYNAP 
                 2160 
               
               
                   
                   
                 HHPFAGYPPG YPMQAYVDPS NPNAGKVLLP TPSMDPVCSP APYDHAQPLV GHSTEPLSAP 
                 2220 
               
               
                   
                   
                 PPVPVVPHVA APVEVSSSQY VAQSDGVVHQ DSSVAVLPVP APGPVQGQ 
                 2268 
               
               
                   
               
               
                 24 
                 IPI00966721 
                 Same as KH 20 
                   
               
               
                   
                 gi:121940485 
                   
                   
               
               
                   
                 Q0VDI3.1 
                   
                   
               
               
                   
               
               
                 25 
                 IPI01012037 
                 MNGEYRGRGF GRGRFQSWKR GRGGGNFSGK WREREHRPDL SKTTGKRTSE QTPQFLLSTK 
                 60 
               
               
                   
                 gi:74735024 
                 TPQSMQSTLD RFIPYKGWKL YFSEVYSDSS PLIEKIQAFE KFFTRHIDLY DKDEIERKGS 
                 120 
               
               
                   
                 Q9UHY7.1 
                 ILVDFKELTE GGEVTNLIPD IATELRDAPE KTLACMGLAI HQVLTKDLER HAAELQAQEG 
                 180 
               
               
                   
                   
                 LSNDGETMVN VPHIHARVYN YEPLTQLKNV RANYYGKYIA LRGTVVRVSN IKPLCTKMAF 
                 240 
               
               
                   
                   
                 LCAACGEIQS FPLPDGKYSL PTKCPVPVCR GRSFTALRSS PLTVTMDWQS IKIQELMSDD 
                 300 
               
               
                   
                   
                 QREAGRIPRT IECELVHDLV DSCVPGDTVT ITGIVKVSNA EEGSRNKNDK CMFLLYIEAN 
                 360 
               
               
                   
                   
                 SISNSKGQKT KSSEDGCKHG MLMEFSLKDL YAIQEIQAEE NLFKLIVNSL CPVIFGHELV 
                 420 
               
               
                   
                   
                 KAGLALALFG GSQKYADDKN RIPIRGDPHI LVVGDPGLGK SQMLQAACNV APRGVYVCGN 
                 480 
               
               
                   
                   
                 TTTTSGLTVT LSKDSSSGDF ALEAGALVLG DQGICGIDEF DKMGNQHQAL LEAMEQQSIS 
                 540 
               
               
                   
                   
                 LAKAGVVCSL PARTSIIAAA NPVGGHYNKA KTVSENLKMG SALLSRFDLV FILLDTPNEH 
                 600 
               
               
                   
                   
                 HDHLLSEHVI AIRAGKQRTI SSATVARMNS QDSNTSVLEV VSEKPLSERL KVVPGETIDP 
                 660 
               
               
                   
                   
                 IPHQLLRKYI GYARQYVYPR LSTEAARVLQ DFYLELRKQS QRLNSSPITT RQLESLIRLT 
                 720 
               
               
                   
                   
                 EARARLELRE EATKEDAEDI VEIMKYSMLG TYSDEFGNLD FERSQHGSGM SNRSTAKRFI 
                 780 
               
               
                   
                   
                 SALNNVAERT YNNIFQFHQL RQIAKELNIQ VADFENFIGS LNDQGYLLKK GPKVYQLQTM 
                 840 
               
               
                   
               
               
                 26 
                 IPI00940730 
                 MVVLSVPAEV TVILLDIEGT TTPIAFVKDI LFPYIEENVK EYLQTHWEEE ECQQDVSLLR 
                 60 
               
               
                   
                 gi: 
                 KQAEEDAHLD GAVPIPAASG NGVDDLQQMI QAVVDNVCWQ MSLDRKTTAL KQLQGHMWRA 
                 120 
               
               
                   
                   
                 AFTAGRMKAE FFADVVPAVR KWREAGMKVY IYSSGSVEAQ KLLFGHSTEG DILELVDGHF 
                 180 
               
               
                   
                   
                 DTKIGHKVES ESYRKIADSI GCSTNNILFL TDVTREASAA EEADVHVAVV VRPGNAGLTD 
                 240 
               
               
                   
                   
                 DEKTYYSLIT SFSELYLPSS T 
                 261 
               
               
                   
               
               
                 27 
                 IPI00977191 
                 MAMESTATAA VAAELVSADK IEDVPAPSTS ADKVESLDVD SEAKKLLGLG QKHLVMGDIP 
                 60 
               
               
                   
                 gi:23503077 
                 AAVNAFQEAA SLLGKKYGET ANECGEAFFF YGKSLLELAR MENGVLGNAL EGVHVEEEEG 
                 120 
               
               
                   
                 P49321.2 
                 EKTEDESLVE NNDNIDEEAR EELREQVYDA MGEKEEAKKT EDKSLAKPET DKEQDSEMEK 
                 180 
               
               
                   
                   
                 GGREDMDISK SAEEPQEKVD LTLDWLTETS EEAKGGAAPE GPNEAEVTSG KPEQEVPDAE 
                 240 
               
               
                   
                   
                 EEKSVSGTDV QEECREKGGQ EKQGEVIVSI EEKPKEVSEE QPVVTLEKQG TAVEVEAESL 
                 300 
               
               
                   
                   
                 DPTVKPVDVG GDEPEEKVVT SENEAGKAVL EQLVGQEVPP AEESPEVTTE AAEASAVEAG 
                 360 
               
               
                   
                   
                 SEVSEKPGQE APVLPKDGAV NGPSVVGDQT PIEPQTSIER LTETKDGSGL EEKVRAKLVP 
                 420 
               
               
                   
                   
                 SQEETKLSVE ESEAAGDGVD TKVAQGATEK SPEDKVQIAA NEETQEREEQ MKEGEETEGS 
                 480 
               
               
                   
                   
                 EEDDKENDKT EEMPNDSVLE NKSLQENEEE EIGNLELAWD MLDLAKIIFK RQETKEAQLY 
                 540 
               
               
                   
                   
                 AAQAHLKLGE VSVESENYVQ AVEEFQSCLN LQEQYLEAHD RLLAETHYQL GLAYGYNSQY 
                 600 
               
               
                   
                   
                 DEAVAQFSKS IEVIENRMAV LNEQVKEAEG SSAEYKKEIE ELKELLPEIR EKIEDAKESQ 
                 660 
               
               
                   
                   
                 RSGNVAELAL KATLVESSTS GFTPGGGGSS VSMIASRKPT DGASSSNCVT DISHLVRKKR 
                 720 
               
               
                   
                   
                 KPEEESPRKD DAKKAKQEPE VNGGSGDAVP SGNEVSENME EEAENQAESR AAVEGTVEAG 
                 780 
               
               
                   
                   
                 ATVESTAC 
                 788 
               
               
                   
               
               
                 28 
                 IPI00022434 
                 MKWVTFISLL FLFSSAYSRG VFRRDAHKSE VAHRFKDLGE ENFKALVLIA FAQYLQQCPF 
                 60 
               
               
                   
                 gi:.113576 
                 EDHVKLVNEV TEFAKTCVAD ESAENCDKSL HTLFGDKLCT VATLRETYGE MADCCAKQEP 
                 120 
               
               
                   
                 P02768.2 
                 ERNECFLQHK DDNPNLPRLV RPEVDVMCTA FHDNEETFLK KYLYEIARRH PYFYAPELLF 
                 180 
               
               
                   
                   
                 FAKRYKAAFT ECCQAADKAA CLLPKLDELR DEGKASSAKQ RLKCASLQKF GERAFKAWAV 
                 240 
               
               
                   
                   
                 ARLSQRFPKA EFAEVSKLVT DLTKVHTECC HGDLLECADD RADLAKYICE NQDSISSKLK 
                 300 
               
               
                   
                   
                 ECCEKPLLEK SHCIAEVEND EMPADLPSLA ADFVESKDVC KNYAEAKDVF LGMFLYEYAR 
                 360 
               
               
                   
                   
                 RHPDYSVVLL LRLAKTYETT LEKCCAAADP HECYAKVFDE FKPLVEEPQN LIKQNCELFE 
                 420 
               
               
                   
                   
                 QLGEYKFQNA LLVRYTKKVP QVSTPTLVEV SRNLGKVGSK CCKHPEAKRM PCAEDYLSVV 
                 480 
               
               
                   
                   
                 LNQLCVLHEK TPVSDRVTKC CTESLVNRRP CFSALEVDET YVPKEFNAET FTFHADICTL 
                 540 
               
               
                   
                   
                 SEKERQIKKQ TALVELVKHK PKATKEQLKA VMDDFAAFVE KCCKADDKET CFAEEGKKLV 
                 600 
               
               
                   
                   
                 AASQAALGL 
                 609 
               
               
                   
               
               
                 29 
                 IPI00022434 
                 Same as KH 28 
                   
               
               
                   
                 gi:113576 
                   
                   
               
               
                   
                 P02768.2 
                   
                   
               
               
                   
               
               
                 30 
                 IPI00219713 
                 MSWSLHPRNL ILYFYALLFL SSTCVAYVAT RDNCCILDER FGSYCPTTCG IADFLSTYQT 
                 60 
               
               
                   
                 gi:20178280 
                 KVDKDLQSLE DILHQVENKT SEVKQLIKAI QLTYNPDESS KPNMIDAATL KSRKMLEEIM 
                 120 
               
               
                   
                 P02679 
                 KYEASILTHD SSIRYLQEIY NSNNQKIVNL KEKVAQLEAQ CQEPCKDTVQ IHDITGKDCQ 
                 180 
               
               
                   
                   
                 DIANKGAKQS GLYFIKPLKA NQQFLVYCEI DGSGNGWTVF QKRLDGSVDF KKNWIQYKEG 
                 240 
               
               
                   
                   
                 FGHLSPTGTT EFWLGNEKIH LISTQSAIPY ALRVELEDWN GRTSTADYAM FKVGPEADKY 
                 300 
               
               
                   
                   
                 RLTYAYFAGG DAGDAFDGFD FGDDPSDKFF TSHNGMQFST WDNDNDKFEG NCAEQDGSGW 
                 360 
               
               
                   
                   
                 WMNKCHAGHL NGVYYQGGTY SKASTPNGYD NGIIWATWKT RWYSMKKTTM KIIPFNRLTI 
                 420 
               
               
                   
                   
                 GEGQQHHLGG AKQVRPEHPA ETEYDSLYPE DDL 
                 453 
               
               
                   
               
               
                 31 
                 IPI00219713 
                 Same as KH 30 
                   
               
               
                   
                 gi:20178280 
                   
                   
               
               
                   
                 P02679 
                   
                   
               
               
                   
               
               
                 32 
                 IPI00220327 
                 MSRQFSSRSG YRSGGGGFSS SAGIINYQRR TTSSSTRRSG GGGGRFSSCG GGGGSFGAGG 
                 60 
               
               
                   
                 gi:238054406 
                 GFGSRSLVNL GGSKSISISV ARGGGRGSGF GGGYGGGGFG GGGFGGGGFG GGGIGGGGFG 
                 120 
               
               
                   
                 P04264.6 
                 GFGSGGGGFG GGGFGGGGYG GGYGPVCPPG GIQEVTINQS LLQPLNVEID PEIQKVKSRE 
                 180 
               
               
                   
                   
                 REQIKSLNNQ FASFIDKVRF LEQQNQVLQT KWELLQQVDT STRTHNLEPY FESFINNLRR 
                 240 
               
               
                   
                   
                 RVDQLKSDQS RLDSELKNMQ DMVEDYRNKY EDEINKRTNA ENEFVTIKKD VDGAYMTKVD 
                 300 
               
               
                   
                   
                 LQAKLDNLQQ EIDFLTALYQ AELSQMQTQI SETNVILSMD NNRSLDLDSI IAEVKAQYED 
                 360 
               
               
                   
                   
                 IAQKSKAEAE SLYQSKYEEL QITAGRHGDS VRNSKIEISE LNRVIQRLRS EIDNVKKQIS 
                 420 
               
               
                   
                   
                 NLQQSISDAE QRGENALKDA KNKLNDLEDA LQQAKEDLAR LLRDYQELMN TKLALDLEIA 
                 480 
               
               
                   
                   
                 TYRTLLEGEE SRMSGECAPN VSVSVSTSHT TISGGGSRGG GGGGYGSGGS SYGSGGGSYG 
                 540 
               
               
                   
                   
                 SGGGGGGGRG SYGSGGSSYG SGGGSYGSGG GGGGHGSYGS GSSSGGYRGG SGGGGGGSSG 
                 600 
               
               
                   
                   
                 GRGSGGGSSG GSIGGRGSSS GGVKSSGGSS SVKFVSTTYS GVTR 
                 644 
               
               
                   
               
               
                 33 
                 IPI00029739 
                 MRLLAKIICL MLWAICVAED CNELPPRRNT EILTGSWSDQ TYPEGTQAIY KCRPGYRSLG 
                 60 
               
               
                   
                 gi:158517847 
                 NVIMVCRKGE WVALNPLRKC QKRPCGHPGD TPFGTFTLTG GNVFEYGVKA VYTCNEGYQL 
                 120 
               
               
                   
                 P08603.4 
                 LGEINYRECD TDGWTNDIPI CEVVKCLPVT APENGKIVSS AMEPDREYHF GQAVRFVCNS 
                 180 
               
               
                   
                   
                 GYKIEGDEEM HCSDDGFWSK EKPKCVEISC KSPDVINGSP ISQKIIYKEN ERFQYKCNMG 
                 240 
               
               
                   
                   
                 YEYSERGDAV CTESGWRPLP SCEEKSCDNP YIPNGDYSPL RIKHRTGDEI TYQCRNGFYP 
                 300 
               
               
                   
                   
                 ATRGNTAKCT STGWIPAPRC TLKPCDYPDI KHGGLYHENM RRPYFPVAVG KYYSYYCDEH 
                 360 
               
               
                   
                   
                 FETPSGSYWD HIHCTQDGWS PAVPCLRKCY FPYLENGYNQ NYGRKFVQGK SIDVACHPGY 
                 420 
               
               
                   
                   
                 ALPKAQTTVT CMENGWSPTP RCIRVKTCSK SSIDIENGFI SESQYTYALK EKAKYQCKLG 
                 480 
               
               
                   
                   
                 YVTADGETSG SITCGKDGWS AQPTCIKSCD IPVFMNARTK NDFTWFKLND TLDYECHDGY 
                 540 
               
               
                   
                   
                 ESNTGSTTGS IVCGYNGWSD LPICYERECE LPKIDVHLVP DRKKDQYKVG EVLKFSCKPG 
                 600 
               
               
                   
                   
                 FTIVGPNSVQ CYHFGLSPDL PICKEQVQSC GPPPELLNGN VKEKTKEEYG HSEVVEYYCN 
                 660 
               
               
                   
                   
                 PRFLMKGPNK IQCVDGEWTT LPVCIVEEST CGDIPELEHG WAQLSSPPYY YGDSVEFNCS 
                 720 
               
               
                   
                   
                 ESFTMIGHRS ITCIHGVWTQ LPQCVAIDKL KKCKSSNLII LEEHLKNKKE FDHNSNIRYR 
                 780 
               
               
                   
                   
                 CRGKEGWIHT VCINGRWDPE VNCSMAQIQL CPPPPQIPNS HNMTTTLNYR DGEKVSVLCQ 
                 840 
               
               
                   
                   
                 ENYLIQEGEE ITCKDGRWQS IPLCVEKIPC SQPPQIEHGT INSSRSSQES YAHGTKLSYT 
                 900 
               
               
                   
                   
                 CEGGFRISEE NETTCYMGKW SSPPQCEGLP CKSPPEISHG VVAHMSDSYQ YGEEVTYKCF 
                 960 
               
               
                   
                   
                 EGFGIDGPAI AKCLGEKWSH PPSCIKTDCL SLPSFENAIP MGEKKDVYKA GEQVTYTCAT 
                 1020 
               
               
                   
                   
                 YYKMDGASNV TCINSRWTGR PTCRDTSCVN PPTVQNAYIV SRQMSKYPSG ERVRYQCRSP 
                 1080 
               
               
                   
                   
                 YEMFGDEEVM CLNGNWTEPP QCKDSTGKCG PPPPIDNGDI TSFPLSVYAP ASSVEYQCQN 
                 1140 
               
               
                   
                   
                 LYQLEGNKRI TCRNGQWSEP PKCLHPCVIS REIMENYNIA LRWTAKQKLY SRTGESVEFV 
                 1200 
               
               
                   
                   
                 CKRGYRLSSR SHTLRTTCWD GKLEYPTCAK R 
                 1231 
               
               
                   
               
               
                 34 
                 IPI00384853 
                 QAHGRCSAGAQFVFCRRSAGAACTQQALSR (Sequence 59-88) 
                   
               
               
                   
                 gi: 
                 CLVGAQCVLSR (Sequence 100-110) 
                   
               
               
                   
                   
                 CTVCTQQALSR (Sequence 125-135) 
                   
               
               
                   
               
               
                 35 
                 IPI00479708 
                 GSASAPTLFP LVSCENSPSD TSSVAVGCLA QDFLPDSITL SWKYKNNSDI SSTRGFPSVL 
                 60 
               
               
                   
                 gi:193806374 
                 RGGKYAATSQ VLLPSKDVMQ GTDEHVVCKV QHPNGNKEKN VPLPVIAELP PKVSVFVPPR 
                 120 
               
               
                   
                 P01871.3 
                 DGFFGNPRKS KLICQATGFS PRQIQVSWLR EGKQVGSGVT TDQVQAEAKE SGPTTYKVTS 
                 180 
               
               
                   
                   
                 TLTIKESDWL GQSMFTCRVD HRGLTFQQNA SSMCVPDQDT AIRVFAIPPS FASIFLTKST 
                 240 
               
               
                   
                   
                 KLTCLVTDLT TYDSVTISWT RQNGEAVKTH TNISESHPNA TFSAVGEASI CEDDWNSGER 
                 300 
               
               
                   
                   
                 FTCTVTHTDL PSPLKQTISR PKGVALHRPD VYLLPPAREQ LNLRESATIT CLVTGFSPAD 
                 360 
               
               
                   
                   
                 VFVQWMQRGQ PLSPEKYVTS APMPEPQAPG RYFAHSILTV SEEEWNTGET YTCVAHEALP 
                 420 
               
               
                   
                   
                 NRVTERTVDK STGKPTLYNV SLVMSDTAGT CY 
                 452 
               
               
                   
               
               
                 36 
                 IPI00298497 
                 MKRMVSWSFH KLKTMKHLLL LLLCVFLVKS QGVNDNEEGF FSARGHRPLD KKREEAPSLR 
                 60 
               
               
                   
                 gi:399492 
                 PAPPPISGGG YRARPAKAAA TQKKVERKAP DAGGCLHADP DLGVLCPTGC QLQEALLQQE 
                 120 
               
               
                   
                 P02675.2 
                 RPIRNSVDEL NNNVEAVSQT SSSSFQYMYL LKDLWQKRQK QVKDNENVVN EYSSELEKHQ 
                 180 
               
               
                   
                   
                 LYIDETVNSN IPTNLRVLRS ILENLRSKIQ KLESDVSAQM EYCRTPCTVS CNIPVVSGKE 
                 240 
               
               
                   
                   
                 CEEIIRKGGE TSEMYLIQPD SSVKPYRVYC DMNTENGGWT VIQNRQDGSV DFGRKWDPYK 
                 300 
               
               
                   
                   
                 QGFGNVATNT DGKNYCGLPG EYWLGNDKIS QLTRMGPTEL LIEMEDWKGD KVKAHYGGFT 
                 360 
               
               
                   
                   
                 VQNEANKYQI SVNKYRGTAG NALMDGASQL MGENRTMTIH NGMFFSTYDR DNDGWLTSDP 
                 420 
               
               
                   
                   
                 RKQCSKEDGG GWWYNRCHAA NPNGRYYWGG QYTWDMAKHG TDDGVVWMNW KGSWYSMRKM 
                 480 
               
               
                   
                   
                 SMKIRPFFPQ Q 
                 491 
               
               
                   
               
               
                 37 
                 IPI00021841 
                 MKAAVLTLAV LFLTGSQARH FWQQDEPPQS PWDRVKDLAT VYVDVLKDSG RDYVSQFEGS 
                 60 
               
               
                   
                 gi:113992 
                 ALGKQLNLKL LDNWDSVTST FSKLREQLGP VTQEFWDNLE KETEGLRQEM SKDLEEVKAK 
                 120 
               
               
                   
                 P02647.1 
                 VQPYLDDFQK KWQEEMELYR QKVEPLRAEL QEGARQKLHE LQEKLSPLGE EMRDRARAHV 
                 180 
               
               
                   
                   
                 DALRTHLAPY SDELRQRLAA RLEALKENGG ARLAEYHAKA TEHLSTLSEK AKPALEDLRQ 
                 240 
               
               
                   
                   
                 GLLPVLESFK VSFLSALEEY TKKLNTQ 
                 267 
               
               
                   
               
               
                 38 
                 IPI00783987 
                 MGPTSGPSLL LLLLTHLPLA LGSPMYSIIT PNILRLESEE TMVLEAHDAQ GDVPVTVTVH 
                 60 
               
               
                   
                 gi:119370332 
                 DFPGKKLVLS SEKTVLTPAT NHMGNVTFTI PANREFKSEK GRNKFVTVQA TFGTQVVEKV 
                 120 
               
               
                   
                 P01024.2 
                 VLVSLQSGYL FIQTDKTIYT PGSTVLYRIF TVNHKLLPVG RTVMVNIENP EGIPVKQDSL 
                 180 
               
               
                   
                   
                 SSQNQLGVLP LSWDIPELVN MGQWKIRAYY ENSPQQVFST EFEVKEYVLP SFEVIVEPTE 
                 240 
               
               
                   
                   
                 KFYYIYNEKG LEVTITARFL YGKKVEGTAF VIFGIQDGEQ RISLPESLKR IPIEDGSGEV 
                 300 
               
               
                   
                   
                 VLSRKVLLDG VQNPRAEDLV GKSLYVSATV ILHSGSDMVQ AERSGIPIVT SPYQIHFTKT 
                 360 
               
               
                   
                   
                 PKYFKPGMPF DLMVFVTNPD GSPAYRVPVA VQGEDTVQSL TQGDGVAKLS INTHPSQKPL 
                 420 
               
               
                   
                   
                 SITVRTKKQE LSEAEQATRT MQALPYSTVG NSNNYLHLSV LRTELRPGET LNVNFLLRMD 
                 480 
               
               
                   
                   
                 RAHEAKIRYY TYLIMNKGRL LKAGRQVREP GQDLVVLPLS ITTDFIPSFR LVAYYTLIGA 
                 540 
               
               
                   
                   
                 SGQREVVADS VWVDVKDSCV GSLVVKSGQS EDRQPVPGQQ MTLKIEGDHG ARVVLVAVDK 
                 600 
               
               
                   
                   
                 GVFVLNKKNK LTQSKIWDVV EKADIGCTPG SGKDYAGVFS DAGLTFTSSS GQQTAQRAEL 
                 660 
               
               
                   
                   
                 QCPQPAARRR RSVQLTEKRM DKVGKYPKEL RKCCEDGMRE NPMRFSCQRR TRFISLGEAC 
                 720 
               
               
                   
                   
                 KKVFLDCCNY ITELRRQHAR ASHLGLARSN LDEDIIAEEN IVSRSEFPES WLWNVEDLKE 
                 780 
               
               
                   
                   
                 PPKNGISTKL MNIFLKDSIT TWEILAVSMS DKKGICVADP FEVTVMQDFF IDLRLPYSVV 
                 840 
               
               
                   
                   
                 RNEQVEIRAV LYNYRQNQEL KVRVELLHNP AFCSLATTKR RHQQTVTIPP KSSLSVPYVI 
                 900 
               
               
                   
                   
                 VPLKTGLQEV EVKAAVYHHF ISDGVRKSLK VVPEGIRMNK TVAVRTLDPE RLGREGVQKE 
                 960 
               
               
                   
                   
                 DIPPADLSDQ VPDTESETRI LLQGTPVAQM TEDAVDAERL KHLIVTPSGC GEQNMIGMTP 
                 1020 
               
               
                   
                   
                 TVIAVHYLDE TEQWEKFGLE KRQGALELIK KGYTQQLAFR QPSSAFAAFV KRAPSTWLTA 
                 1080 
               
               
                   
                   
                 YVVKVFSLAV NLIAIDSQVL CGAVKWLILE KQKPDGVFQE DAPVIHQEMI GGLRNNNEKD 
                 1140 
               
               
                   
                   
                 MALTAFVLIS LQEAKDICEE QVNSLPGSIT KAGDFLEANY MNLQRSYTVA IAGYALAQMG 
                 1200 
               
               
                   
                   
                 RLKGPLLNKF LTTAKDKNRW EDPGKQLYNV EATSYALLAL LQLKDFDFVP PVVRWLNEQR 
                 1260 
               
               
                   
                   
                 YYGGGYGSTQ ATFMVFQALA QYQKDAPDHQ ELNLDVSLQL PSRSSKITHR IHWESASLLR 
                 1320 
               
               
                   
                   
                 SEETKENEGF TVTAEGKGQG TLSVVTMYHA KAKDQLTCNK FDLKVTIKPA PETEKRPQDA 
                 1380 
               
               
                   
                   
                 KNTMILEICT RYRGDQDATM SILDISMMTG FAPDTDDLKQ LANGVDRYIS KYELDKAFSD 
                 1440 
               
               
                   
                   
                 RNTLIIYLDK VSHSEDDCLA FKVHQYFNVE LIQPGAVKVY AYYNLEESCT RFYHPEKEDG 
                 1500 
               
               
                   
                   
                 KLNKLCRDEL CRCAEENCFI QKSDDKVTLE ERLDKACEPG VDYVYKTRLV KVQLSNDFDE 
                 1560 
               
               
                   
                   
                 YIMAIEQTIK SGSDEVQVGQ QRTFISPIKC REALKLEEKK HYLMWGLSSD FWGEKPNLSY 
                 1620 
               
               
                   
                   
                 IIGKDTWVEH WPEEDECQDE ENQKQCQDLG AFTESMVVFG CPN 
                 1663 
               
               
                   
               
               
                 39 
                 IPI00878282 
                 MKWVTFISLL FLFSSAYSRG VFRRDAHKSE VAHRFKDLGE ENFKALVLIA FAQYLQQCPF 
                 60 
               
               
                   
                 gi:113576 
                 EDHVKLVNEV TEFAKTCVAD ESAENCDKSL HTLFGDKLCT VATLRETYGE MADCCAKQEP 
                 120 
               
               
                   
                 P02768.2 
                 ERNECFLQHK DDNPNLPRLV RPEVDVMCTA FHDNEETFLK KYLYEIARRH PYFYAPELLF 
                 180 
               
               
                   
                   
                 FAKRYKAAFT ECCQAADKAA CLLPKLDELR DEGKASSAKQ RLKCASLQKF GERAFKAWAV 
                 240 
               
               
                   
                   
                 ARLSQRFPKA EFAEVSKLVT DLTKVHTECC HGDLLECADD RADLAKYICE NQDSISSKLK 
                 300 
               
               
                   
                   
                 ECCEKPLLEK SHCIAEVEND EMPADLPSLA ADFVESKDVC KNYAEAKDVF LGMFLYEYAR 
                 360 
               
               
                   
                   
                 RHPDYSVVLL LRLAKTYETT LEKCCAAADP HECYAKVFDE FKPLVEEPQN LIKQNCELFE 
                 420 
               
               
                   
                   
                 QLGEYKFQNA LLVRYTKKVP QVSTPTLVEV SRNLGKVGSK CCKHPEAKRM PCAEDYLSVV 
                 480 
               
               
                   
                   
                 LNQLCVLHEK TPVSDRVTKC CTESLVNRRP CFSALEVDET YVPKEFNAET FTFHADICTL 
                 540 
               
               
                   
                   
                 SEKERQIKKQ TALVELVKHK PKATKEQLKA VMDDFAAFVE KCCKADDKET CFAEEGKKLV 
                 600 
               
               
                   
                   
                 AASQAALGL 
                 609 
               
               
                   
               
               
                 40 
                 IPI00784842 
                 GRFTISGDISTNTLYLQMHSLR (Sequence 85-106) 
                   
               
               
                   
                 gi: 
                 TPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAK (Sequence 284-316) 
                   
               
               
                   
                   
                 ALPAPIEK (Sequence 355-362) 
                   
               
               
                   
                   
                 GQPREPQVYTLPPSRDELTKGFYPSDIAVEWESNGQPENNYK (Sequence 369-420) 
                   
               
               
                   
               
               
                 41 
                 IPI00022434 
                 Same as KH28 
                   
               
               
                   
                 gi:113576 
                   
                   
               
               
                   
                 P02768.2 
                   
                   
               
               
                   
               
               
                 42 
                 IPI00298497 
                 Same as KH36 
                   
               
               
                   
                 gi:399492 
                   
                   
               
               
                   
                 P02675.2 
                   
                   
               
               
                   
               
               
                 43 
                 IPI00965713 
                 MKRMVSWSFH KLKTMKHLLL LLLCVFLVKS QGVNDNEEGF FSARGHRPLD KKREEAPSLR 
                 60 
               
               
                   
                 gi:399492 
                 PAPPPISGGG YRARPAKAAA TQKKVERKAP DAGGCLHADP DLGVLCPTGC QLQEALLQQE 
                 120 
               
               
                   
                 P02675.2 
                 RPIRNSVDEL NNNVEAVSQT SSSSFQYMYL LKDLWQKRQK QVKDNENVVN EYSSELEKHQ 
                 180 
               
               
                   
                   
                 LYIDETVNSN IPTNLRVLRS ILENLRSKIQ KLESDVSAQM EYCRTPCTVS CNIPVVSGKE 
                 240 
               
               
                   
                   
                 CEEIIRKGGE TSEMYLIQPD SSVKPYRVYC DMNTENGGWT VIQNRQDGSV DFGRKWDPYK 
                 300 
               
               
                   
                   
                 QGFGNVATNT DGKNYCGLPG EYWLGNDKIS QLTRMGPTEL LIEMEDWKGD KVKAHYGGFT 
                 360 
               
               
                   
                   
                 VQNEANKYQI SVNKYRGTAG NALMDGASQL MGENRTMTIH NGMFFSTYDR DNDGWLTSDP 
                 420 
               
               
                   
                   
                 RKQCSKEDGG GWWYNRCHAA NPNGRYYWGG QYTWDMAKHG TDDGVVWMNW KGSWYSMRKM 
                 480 
               
               
                   
                   
                 SMKIRPFFPQ Q 
                 491 
               
               
                   
               
               
                 44 
                 IPI00645363 
                 NSLYLQMNSLRAEDTALYYCAK (Sequence 96-117) 
                   
               
               
                   
                 gi: 
                 GPSVFPLAPSSK (Sequence 147-158) 
                   
               
               
                   
                   
                 TPEVTCVVVDVSHEDPEVK (Sequence 281-299) 
                   
               
               
                   
                   
                 FNWYVDGVEVHNAK (Sequence 300-313) 
                   
               
               
                   
                   
                 ALPAPIEK (Sequence 352-359) 
                   
               
               
                   
                   
                 GQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYK  
                   
               
               
                   
                   
                 (Sequence 366-417) 
                   
               
               
                   
               
               
                 45 
                 IPI00219713 
                 Same as KH30 
                   
               
               
                   
                 gi:20178280 
                   
                   
               
               
                   
                 P02679 
                   
                   
               
               
                   
               
               
                 46 
                 IPI00022371 
                 MKALIAALLL ITLQYSCAVS PTDCSAVEPE AEKALDLINK RRRDGYLFQL LRIADAHLDR 
                 60 
               
               
                   
                 gi:123523 
                 VENTTVYYLV LDVQESDCSV LSRKYWNDCE PPDSRRPSEI VIGQCKVIAT RHSHESQDLR 
                 120 
               
               
                   
                 P04196.1 
                 VIDFNCTTSS VSSALANTKD SPVLIDFFED TERYRKQANK ALEKYKEEND DFASFRVDRI 
                 180 
               
               
                   
                   
                 ERVARVRGGE GTGYFVDFSV RNCPRHHFPR HPNVFGFCRA DLFYDVEALD LESPKNLVIN 
                 240 
               
               
                   
                   
                 CEVFDPQEHE NINGVPPHLG HPFHWGGHER SSTTKPPFKP HGSRDHHHPH KPHEHGPPPP 
                 300 
               
               
                   
                   
                 PDERDHSHGP PLPQGPPPLL PMSCSSCQHA TFGTNGAQRH SHNNNSSDLH PHKHHSHEQH 
                 360 
               
               
                   
                   
                 PHGHHPHAHH PHEHDTHRQH PHGHHPHGHH PHGHHPHGHH PHGHHPHCHD FQDYGPCDPP 
                 420 
               
               
                   
                   
                 PHNQGHCCHG HGPPPGHLRR RGPGKGPRPF HCRQIGSVYR LPPLRKGEVL PLPEANFPSF 
                 480 
               
               
                   
                   
                 PLPHHKHPLK PDNQPFPQSV SESCPGKFKS GFPQVSMFFT HTFPK 
                 525 
               
               
                   
               
               
                 47 
                 IPI00022371 
                 Same as KH46 
                   
               
               
                   
                 gi:123523 
                   
                   
               
               
                   
                 P04196.1 
                   
                   
               
               
                   
               
               
                 48 
                 IPI00022463 
                 MRLAVGALLV CAVLGLCLAV PDKTVRWCAV SEHEATKCQS FRDHMKSVIP SDGPSVACVK 
                 60 
               
               
                   
                 gi:313104271 
                 KASYLDCIRA IAANEADAVT LDAGLVYDAY LAPNNLKPVV AEFYGSKEDP QTFYYAVAVV 
                 120 
               
               
                   
                 P02787.3 
                 KKDSGFQMNQ LRGKKSCHTG LGRSAGWNIP IGLLYCDLPE PRKPLEKAVA NFFSGSCAPC 
                 180 
               
               
                   
                   
                 ADGTDFPQLC QLCPGCGCST LNQYFGYSGA FKCLKDGAGD VAFVKHSTIF ENLANKADRD 
                 240 
               
               
                   
                   
                 QYELLCLDNT RKPVDEYKDC HLAQVPSHTV VARSMGGKED LIWELLNQAQ EHFGKDKSKE 
                 300 
               
               
                   
                   
                 FQLFSSPHGK DLLFKDSAHG FLKVPPRMDA KMYLGYEYVT AIRNLREGTC PEAPTDECKP 
                 360 
               
               
                   
                   
                 VKWCALSHHE RLKCDEWSVN SVGKIECVSA ETTEDCIAKI MNGEADAMSL DGGFVYIAGK 
                 420 
               
               
                   
                   
                 CGLVPVLAEN YNKSDNCEDT PEAGYFAIAV VKKSASDLTW DNLKGKKSCH TAVGRTAGWN 
                 480 
               
               
                   
                   
                 IPMGLLYNKI NHCRFDEFFS EGCAPGSKKD SSLCKLCMGS GLNLCEPNNK EGYYGYTGAF 
                 540 
               
               
                   
                   
                 RCLVEKGDVA FVKHQTVPQN TGGKNPDPWA KNLNEKDYEL LCLDGTRKPV EEYANCHLAR 
                 600 
               
               
                   
                   
                 APNHAVVTRK DKEACVHKIL RQQQHLFGSN VTDCSGNFCL FRSETKDLLF RDDTVCLAKL 
                 660 
               
               
                   
                   
                 HDRNTYEKYL GEEYVKAVGN LRKCSTSSLL EACTFRRP 
                 698 
               
               
                   
               
               
                 49 
                 IPI00023006 
                 MCDDEETTAL VCDNGSGLVK AGFAGDDAPR AVFPSIVGRP RHQGVMVGMG QKDSYVGDEA 
                 60 
               
               
                   
                 gi:54036697 
                 QSKRGILTLK YPIEHGIITN WDDMEKIWHH TFYNELRVAP EEHPTLLTEA PLNPKANREK 
                 120 
               
               
                   
                 P68032.1 
                 MTQIMFETFN VPAMYVAIQA VLSLYASGRT TGIVLDSGDG VTHNVPIYEG YALPHAIMRL 
                 180 
               
               
                   
                   
                 DLAGRDLTDY LMKILTERGY SFVTTAEREI VRDIKEKLCY VALDFENEMA TAASSSSLEK 
                 240 
               
               
                   
                   
                 SYELPDGQVI TIGNERFRCP ETLFQPSFIG MESAGIHETT YNSIMKCDID IRKDLYANNV 
                 300 
               
               
                   
                   
                 LSGGTTMYPG IADRMQKEIT ALAPSTMKIK IIAPPERKYS VWIGGSILAS LSTFQQMWIS 
                 360 
               
               
                   
                   
                 KQEYDEAGPS IVHRKCF 
                 377 
               
               
                   
               
               
                 50 
                 IPI00021841 
                 Same as KH 37 
                   
               
               
                   
                 gi:113992 
                   
                   
               
               
                   
                 P02647.1 
                   
                   
               
               
                   
               
               
                 51 
                 IPI00023006 
                 Same as KH49 
                   
               
               
                   
                 gi:54036697 
                   
                   
               
               
                   
                 P68032.1 
                   
                   
               
               
                   
               
               
                 52 
                 IPI00930226 
                 MEEEIAALVI DNGSGMCKAG FAGDDAPRAV FPSIVGRPRH QGVMVGMGQK DSYVGDEAQS 
                 60 
               
               
                   
                 gi:54036678 
                 KRGILTLKYP IEHGIVTNWD DMEKIWHHTF YNELRVAPEE HPVLLTEAPL NPKANREKMT 
                 120 
               
               
                   
                 P63261.1 
                 QIMFETFNTP AMYVAIQAVL SLYASGRTTG IVMDSGDGVT HTVPIYEGYA LPHAILRLDL 
                 180 
               
               
                   
                   
                 AGRDLTDYLM KILTERGYSF TTTAEREIVR DIKEKLCYVA LDFEQEMATA ASSSSLEKSY 
                 240 
               
               
                   
                   
                 ELPDGQVITI GNERFRCPEA LFQPSFLGME SCGIHETTFN SIMKCDVDIR KDLYANTVLS 
                 300 
               
               
                   
                   
                 GGTTMYPGIA DRMQKEITAL APSTMKIKII APPERKYSVW IGGSILASLS TFQQMWISKQ 
                 360 
               
               
                   
                   
                 EYDESGPSIV HRKCF 
                 375 
               
               
                   
               
               
                 53 
                 gi:194373497 
                 MEESLPTNPD SSTMGPWCYT TDPTVRRQEC SIPVCGQDQV TVAMTPRSEG SSVNLSPPLE 
                 60 
               
               
                   
                 BAG56844.1 
                 QCVPDRGQQY QGRLAVTTHG LPCLAWASAQ AKALSKHQDF NSAVQLVENF CRNPDGDEEG 
                 120 
               
               
                   
                   
                 VWCYVAGKPG DFGYCDLNYC EEAVEEETGD GLDEDSDRAI EGRTATSEYQ TFFNPRTFGS 
                 180 
               
               
                   
                   
                 GEADCGLRPL FEKKSLEDKT ERELLESYID GRIVEGSDAE IGMSPWQVML FRKSPQELLC 
                 240 
               
               
                   
                   
                 GASLISDRWV LTAAHCLLYP PWDKNFTEND LLVRIGKHSR TRYERNIEKI SMLEKIYIHP 
                 300 
               
               
                   
                   
                 RYNWRENLDR DIALMKLKKP VAFSDYIHPV CLPDRETAAS LLQAGYKGRV TGWGNLKETW 
                 360 
               
               
                   
                   
                 TANVGKGQPS VLQVVNLPIV ERPVCKDSTR IRITDNMFCA GYKPDEGKRG DACEGDSGGP 
                 420 
               
               
                   
                   
                 FVMKSPFNNR WYQMGIVSWG EGCDRDGKYG FYTHVFRLKK WIQKVIDQFG E 
                 471 
               
               
                   
               
               
                 54 
                 gi:194380034 
                 MNQLRGKKSC HTGLGRSAGW NIPIGLLYCD LPEPRKPLEK AMANFFSGSC APCADGTDFP 
                 60 
               
               
                   
                 BAG58369.1 
                 QLCQLCPGCG CSTLNQYFGY SGAFKCLKDG AGDVAFVKHS TIFENLANKA DRDQYELLCL 
                 120 
               
               
                   
                   
                 DNTRKPVDEY KDCHLAQVPS HTVVARSMGS KEDLIWELLN QAQEHFGKDK SKEFQLFSSP 
                 180 
               
               
                   
                   
                 HGKDLLFKDS AHGFLKVPPR MDAKMYLGYE YVTAIRNLRE GTCPEAPTDE CKPVKWCALS 
                 240 
               
               
                   
                   
                 HHERLKCDEW SVNSVGKIEC VSAETTEDCI AKIMNGEADA MSLDGGFVYI AGKCGLVPVL 
                 300 
               
               
                   
                   
                 AENYNKSDNC EDTPEAGYFA VAVVKKSASD LTWDNLKGKK SCHTAVGRTA GWNIPMGLLY 
                 360 
               
               
                   
                   
                 NKINHCRFDE FFSEGCAPGS KKDSSLCKLC MGSGLNLCEP NNKEGYYGYT GAFRCLVEKG 
                 420 
               
               
                   
                   
                 DVAFVKHQTV PQNTGGKNPD PWAKNLNEKD YELLCLDGTR KPVEEYANCH LARAPNHAVV 
                 480 
               
               
                   
                   
                 TRKDKEACVH KILRQQQHLF GSNVTDCSGN FCLFRSETKD LLFRDDTVCL AKLHDRNTYE 
                 540 
               
               
                   
                   
                 KYLGEEYVKA VGNLRKCSTS SLLEACTFRR P 
                 571 
               
               
                   
               
               
                 55 
                 gi:194380034 
                 Same as 54 
                   
               
               
                   
                 BAG58369.1 
               
               
                   
               
             
          
         
       
     
         [0022]    The details of one or more embodiments of the present invention are set forth in the accompanying figures and the description below. Further areas of applicability will become apparent from the description provided herein. It should be understood that the description and specific examples are intended for purposes of illustration only and are not intended to limit the scope of the present disclosure. 
     
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         [0023]      FIG. 1  is a graph depicting percentages of T and B lymphocytes in peripheral blood, with and without therapeutic RAAS 105 treatment. 
           [0024]      FIG. 2  is a graph depicting percentages of T and B lymphocytes in peripheral blood, with further analysis done on CD4 and CD8 T cell lineages, with and without therapeutic RAAS 105 treatment. 
           [0025]      FIG. 3  is a graph depicting percentages of CD4 and CD8 T cells in peripheral blood, with and without therapeutic RAAS 105 treatment. 
           [0026]      FIG. 4  is a graph depicting percentages of CD4 and CD8 T cells in peripheral blood, with further analysis done on the percentages of CD11c +  dendritic cells (DC) and Gr-1 +  granulocytes. 
           [0027]      FIG. 5  is graphs depicting percentages of dendritic cells and granulocytes in peripheral blood, with and without therapeutic RAAS 105 treatment. 
           [0028]      FIG. 6  is graph showing another representation of Gr-1 vs. CD 11c cells, with and without therapeutic RAAS 105 treatment. 
           [0029]      FIG. 7  is a graph depicting the percentage of monocytes in peripheral blood, with and without therapeutic RAAS 105 treatment. 
           [0030]      FIG. 8  is a graph showing another representation of monocytes in peripheral blood, with and without therapeutic RAAS 105 treatment. 
           [0031]      FIG. 9  is graphs depicting percentages of T and B lymphocytes in the spleen, with and without therapeutic RAAS 105 treatment. 
           [0032]      FIG. 10  is a graph showing another representation of T and B lymphocytes in the spleen, with and without therapeutic RAAS 105 treatment. 
           [0033]      FIG. 11  is graphs depicting percentages of CD4 and CD8 T cells in the spleen, with and without therapeutic RAAS 105 treatment. 
           [0034]      FIG. 12  is a graph showing another representation of CD4 and CD8 T cells in the spleen, with CD3 T cells being gated, with and without therapeutic RAAS 105 treatment. 
           [0035]      FIG. 13  is graphs depicting T cell subset percentages in the spleen, with and without therapeutic RAAS 105 treatment. 
           [0036]      FIG. 14  is a graph of CD4 T cell subset percentages in the spleen, with and without therapeutic RAAS 105 treatment. 
           [0037]      FIG. 15  is graphs depicting T cell subset percentages in the spleen, with and without therapeutic RAAS 105 treatment. 
           [0038]      FIG. 16  is a graph of CD8 T cell subset percentages in the spleen, with and without therapeutic RAAS 105 treatment. 
           [0039]      FIG. 17  is a graph depicting percentages of regulatory T cells in the spleen, with and without therapeutic RAAS 105 treatment. 
           [0040]      FIG. 18  is another graphical representation of percentages of regulatory T cells in the spleen, with and without therapeutic RAAS 105 treatment. 
           [0041]      FIG. 19  is graphs depicting percentages of mDc and pDcs in the spleen, with and without therapeutic RAAS 105 treatment. 
           [0042]      FIG. 20  is another graphical representation of mDC and pDcs in the spleen, with and without therapeutic RAAS 105 treatment. 
           [0043]      FIG. 21  is graphs depicting percentages of macrophages and granulocytes in the spleen, with and without therapeutic RAAS 105 treatment. 
           [0044]      FIG. 22  is another graphical representation of percentages of macrophages and granulocytes in the spleen, with and without therapeutic RAAS 105 treatment. 
           [0045]      FIG. 23  is a graph depicting percentages of T cells in the lymph nodes, with and without therapeutic RAAS 105 treatment. 
           [0046]      FIG. 24  is graphs showing percentages of CD3 T cells in the lymph nodes, with and without therapeutic RAAS 105 treatment. 
           [0047]      FIG. 25  is graphs depicting percentages of CD4 and CD8 T cells in the lymph nodes, with and without therapeutic RAAS 105 treatment. 
           [0048]      FIG. 26  is another graphical representation of CD4 and CD8 T cells in the lymph nodes, with and without therapeutic RAAS 105 treatment. 
           [0049]      FIG. 27  is graphs depicting CD4 T cell subset percentages in the lymph nodes, with and without therapeutic RAAS 105 treatment. 
           [0050]      FIG. 28  is another graphical representation of CD4 T cell subset percentages in the lymph nodes, with and without therapeutic RAAS 105 treatment. 
           [0051]      FIG. 29  is graphs depicting CD8 T cell subset percentages in the lymph nodes, with and without therapeutic RAAS 105 treatment. 
           [0052]      FIG. 30  is another graphical representation of CD8 T cell subset percentages in the lymph nodes, with and without therapeutic RAAS 105 treatment. 
           [0053]      FIG. 31  is a graph depicting percentages of Foxp3 regulatory T cells in the lymph nodes, with and without therapeutic RAAS 105 treatment. 
           [0054]      FIG. 32  is another graphical representation of Foxp3 regulatory T cells in the lymph nodes, with and without therapeutic RAAS 105 treatment. 
           [0055]      FIG. 33  is a graph depicting percentages of DCs in the lymph nodes, with and without therapeutic RAAS 105 treatment. 
           [0056]      FIG. 34  is another graphical representation of percentages of DCs in the lymph nodes, with and without therapeutic RAAS 105 treatment. 
           [0057]      FIG. 35  is graphs depicting percentages of macrophages and granulocytes in the lymph nodes, with and without therapeutic RAAS 105 treatment. 
           [0058]      FIG. 36  is another graphical representation of percentages of macrophages and granulocytes in the lymph nodes, with and without therapeutic RAAS 105 treatment. 
           [0059]      FIG. 37  is graphs depicting T and B lymphocytes in peripheral blood, with and without prophylactic RAAS 105 treatment. 
           [0060]      FIG. 38  is another graphical representation of T and B cells in peripheral blood, with and without prophylactic RAAS 105 treatment. 
           [0061]      FIG. 39  is graphs depicting percentages of CD4 and CD 8 T cells in peripheral blood, with and without prophylactic RAAS 105 treatment. 
           [0062]      FIG. 40  is another graphical representation of CD4 and CD 8 T cells in peripheral blood, with and without prophylactic RAAS 105 treatment. 
           [0063]      FIG. 41  is graphs depicting percentages of dendritic cells and granulocytes in peripheral blood, with and without prophylactic RAAS 105 treatment. 
           [0064]      FIG. 42  is another graphical representation of dendritic cells and granulocytes in peripheral blood, with and without prophylactic RAAS 105 treatment. 
           [0065]      FIG. 43  is a graph depicting percentages of monocytes in peripheral blood, with and without prophylactic RAAS 105 treatment. 
           [0066]      FIG. 44  is another graphical representation of percentages of monocytes in peripheral blood, with and without prophylactic RAAS 105 treatment. 
           [0067]      FIG. 45  is graphs depicting percentages of T and B lymphocytes in the spleen, with and without prophylactic RAAS 105 treatment. 
           [0068]      FIG. 46  is another graphical representation of percentages of T and B lymphocytes in the spleen, with and without prophylactic RAAS 105 treatment. 
           [0069]      FIG. 47  is graphs depicting percentages of CD4 and CD8 T cells in the spleen, with and without prophylactic RAAS 105 treatment. 
           [0070]      FIG. 48  is another graphical representation of percentages of CD4 and CD8 T cells in the spleen, with and without prophylactic RAAS 105 treatment. 
           [0071]      FIG. 49  is graphs depicting subset percentages of T cells in the spleen, with and without prophylactic RAAS 105 treatment. 
           [0072]      FIG. 50  is another graphical representation of subset percentages of T cells in the spleen, with and without prophylactic RAAS 105 treatment. 
           [0073]      FIG. 51  is graphs depicting subset percentages of T cells in the spleen, with and without prophylactic RAAS 105 treatment. 
           [0074]      FIG. 52  is another graphical representation of subset percentages of T cells in the spleen, with and without prophylactic RAAS 105 treatment. 
           [0075]      FIG. 53  is a graph depicting Foxp3 regulator T cells in the spleen, with and without prophylactic RAAS 105 treatment. 
           [0076]      FIG. 54  is another graphical representation of Foxp3 regulator T cells in the spleen, with and without prophylactic RAAS 105 treatment. 
           [0077]      FIG. 55  is graphs depicting percentages of pDCs and mDCs in the spleen, with and without prophylactic RAAS 105 treatment. 
           [0078]      FIG. 56  is another graphical representation of percentages of pDCs and mDCs in the spleen, with and without prophylactic RAAS 105 treatment. 
           [0079]      FIG. 57  is graphs depicting percentages of macrophages and granulocytes in the spleen, with and without prophylactic RAAS 105 treatment. 
           [0080]      FIG. 58  is another graphical representation of percentages of macrophages and granulocytes in the spleen, with and without prophylactic RAAS 105 treatment. 
           [0081]      FIG. 59  is a graph depicting percentages of T cells in the lymph nodes, with and without prophylactic RAAS 105 treatment. 
           [0082]      FIG. 60  is another graphical representation of percentages of CD3 T cells in the lymph nodes, with and without prophylactic RAAS 105 treatment. 
           [0083]      FIG. 61  is graphs depicting percentages of CD4 and CD8 T cells in the lymph nodes, with and without prophylactic RAAS 105 treatment. 
           [0084]      FIG. 62  is another graphical representation of percentages of CD4 and CD8 T cells in the lymph nodes, with and without prophylactic RAAS 105 treatment. 
           [0085]      FIG. 63  is graphs depicting T cell subset percentages in the lymph nodes, with and without prophylactic RAAS 105 treatment. 
           [0086]      FIG. 64  is another graphical representation of T cell subset percentages in the lymph nodes, with and without prophylactic RAAS 105 treatment. 
           [0087]      FIG. 65  is graphs depicting T cell subset percentages in the lymph nodes, with and without prophylactic RAAS 105 treatment. 
           [0088]      FIG. 66  is another graphical representation of T cell subset percentages in the lymph nodes, with and without prophylactic RAAS 105 treatment. 
           [0089]      FIG. 67  is a graph depicting percentages of Foxp3 regulatory T cells in the lymph nodes, with and without prophylactic RAAS 105 treatment. 
           [0090]      FIG. 68  is another graphical representation of Foxp3 regulatory T cells in the lymph nodes, with and without prophylactic RAAS 105 treatment. 
           [0091]      FIG. 69  is a graph depicting percentages of DCs in the lymph nodes, with and without prophylactic RAAS 105 treatment. 
           [0092]      FIG. 70  is another graphical representation of percentages of DCs in the lymph nodes, with and without prophylactic RAAS 105 treatment. 
           [0093]      FIG. 71  is graphs depicting percentages of macrophages and granulocytes in the lymph nodes, with and without prophylactic RAAS 105 treatment. 
           [0094]      FIG. 72  is another graphical representation of percentages of macrophages and granulocytes in the lymph nodes, with and without prophylactic RAAS 105 treatment. 
           [0095]      FIG. 73  is a process flowchart of the manufacturing of AFOD RAAS 102 from fraction paste. 
           [0096]      FIG. 74  is a process flowchart of the manufacturing of AFOD RAAS 104 HBIG purification process from Fraction paste. 
           [0097]      FIG. 75  is a protein analysis of HBIG beside the immunoglobulin proteins containing the protein TF serotransferrin. 
           [0098]      FIG. 76  is a protein analysis comparison of immunoglobulin from fraction II+III paste, immunoglobulin produced from fraction III paste, and hepatitis B immunoglobulin produced from fraction II+III paste, including a depiction of the different proteins in each of the products alongside the main immunoglobulin protein analysis. 
           [0099]      FIG. 77  is a process flowchart for AFOD RAAS 105. 
           [0100]      FIG. 78  is a process flowchart for AFOD RAAS 105. 
       
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
       [0101]    Characterization of Lymphoid Tissues and Peripheral Blood in HBV Infected BALB/c Mice Treated with RAAS 105 
       Executive Summary 
       [0102]    Investigation was made into the effects of RAAS 105 on multiple cell lineages in lymphoid tissues and peripheral blood in HBV infected BALB/c mice. HBV infection and RAAS 105 treatment were performed by ID unit at Wuxi. At the termination, blood samples and lymphoid tissues were provided to us for analysis of various cell lineages by FACS. 
         [0103]    Two independent experiments were performed. One experiment was to test therapeutic effects of RAAS 105 and the other experiment was to test prophylactic effects of RAAS 105. 
         [0104]    Compared with the vehicle group, the differences observed in the animals treated with RAAS 105 therapeutically include: 1) percentages of T cells and B cells in peripheral blood, spleen and lymph nodes were decreased significantly; 2) CD62L was greatly downregulated on both CD4 +  and CD8 +  T cells in the spleen and lymph nodes; 3) granulocytes and monocytes/macrophages in peripheral blood and lymph nodes increased significantly; 4) the percentages of regulatory T cells (CD4 + CD25 + Foxp3 + ) in the spleen and lymph nodes were increased significantly. 
         [0105]    However, prophylactic treatment with RAAS 105 led to somewhat different results. In the group treated with RAAS 105, T- and B-lymphocytes were also decreased. The percentages of monocytes and macrophages were increased albeit to a less degree. 
         [0106]    These results suggested that administration of RAAS 105 had significant effects on the frequencies of immune cell lineages. 
         [0000]    
       
         
               
             
               
               
               
             
           
               
                   
               
               
                 List of Abbreviations 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                   
                 FACS 
                 Flow Cytometry 
               
               
                   
                 mDC 
                 Myeloid dendritic cell 
               
               
                   
                 pDC 
                 Plasmacytoid dendritic cell 
               
               
                   
                   
               
             
          
         
       
     
       Materials and Methods 
     Materials 
     Reagents 
       [0000]    
       
         FITC, Rat Anti-Mouse CD4, BD, Cat: 557307 
         PerCP-Cy5.5, Rat Anti-Mouse CD4, BD, Cat: 550954 
         FITC, Rat Anti-Mouse CD3 molecular complex, BD, Cat: 561798 
         PerCP-Cy5.5, Rat Anti-Mouse CD3, BD, Cat: 560527 
         PerCP-Cy5.5, Rat Anti-Mouse CD8a, BD, Cat: 551162 
         PE, Rat Anti-Mouse CD8a, BD, Cat: 553032 
         PE, Rat Anti-Mouse B220/CD45R, BD, Cat: 553089 
         APC, Rat Anti-Mouse CD11b, BD, Cat: 553312 
         APC, Ar Ham Anti-Mouse CD11c, BD, Cat: 550261 
         PE, Rat Anti-Mouse CD62L, BD, Cat: 553151 
         APC, Rat Anti-Mouse CD44, BD, Cat: 559250 
         PE, Rat Anti-Mouse Gr-1 (Ly-6G and Ly-6C), BD, Cat: 553128 
         Alexa Fluor® 647, Rat Anti-Mouse Foxp3, BD, Cat: 560401 
         PerCP-Cy5.5, Rat Anti-Mouse CD19, BD, Cat: 551001 
         PE, Rat Anti-Mouse CD25, BD, Cat: 553075 
         ACK Lysing buffer, Invitrogen, Cat: A10492-01 
         RPMI 1640 medium, Invitrogen Gibco, Cat: 22400105 
         Dulbecco&#39;s Phosphate Buffered Saline, Thermo. Cat: SH30028.01B. 
         Fetal bovine serum, Invitrogen Gibco, Cat: 10099141 
       
     
       Equipment 
       [0000]    
       
         Vi-CELL Cell Viability Analyzer, Beckman Coulter, Cat: 731050 
         FACS Caliburflow cytometer, BD, Cat: 342975 
         Cell strainer (70 μm), BD, Cat: 352350 
         BD Falcon tubes (12×75 mm, 5 ml), BD, Cat: 352054 
       
     
       Methods 
       [0130]    Peripheral blood was collected through cardiac puncture. After removing red blood cells with lysis buffer followed by two rounds of washing using 1×PBS, mononuclear cells (monocytes, macrophages, dendritic cells, and lymphocytes) and granulocytes were obtained. Spleen and lymph nodes cell suspension were obtained after filtering through 70 μm cell strainer. Cell viability and number were analyzed by Vi-CELL Cell Viability Analyzer followed by cell surface staining. Cells were centrifuged and resuspended in staining buffer (0.08% NaN 3 /PBS+1% FBS) containing appropriate fluorescent-conjugated antibodies. After 30 min incubation at 4° C. in the dark, cells were washed twice with 0.08% NaN 3 /PBS (200 μl per sample), and resuspended with 400 μl 0.08% NaN 3 /PBS in BD Falcon tubes (12×75 mm, 5 ml) followed by FACS analysis. 
       Data Analysis 
       [0131]    FACS data were analyzed by flowjo software. 
       Study Summary 
     Study Initiation Date and Completion Date 
       [0132]    To investigate the therapeutic and prophylactic effect of RAAS 105 on the immune system in mice infected with HBV, the study had divided into two parts. 
       Study Purpose 
       [0133]    The purpose of this study was to investigate the effect of RAAS 105 on cellular composition in lymphoid tissues and peripheral blood of HBV infected mice treated with RAAS 105. 
       Study Results 
       [0134]    Effect of Therapeutic Treatment with RAAS 105 
       Mice Information 
       [0135]    Total 10 female BALB/c mice including 2 naïve mice at the same age were transferred from Infectious Disease (ID) Group of WuxiApptec. The group and the regimen information were shown by Table 1. 
         [0000]    
       
         
               
             
               
               
               
               
               
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 1 
               
             
             
               
                   
               
               
                 The experimental group and dosing regimen 
               
               
                 of the 1 st  part of the study 
               
             
          
           
               
                   
                   
                   
                   
                 1 st  or last 
                   
               
               
                 Groups 
                 N 
                 Group ID 
                 Dose 
                 dosing 
                 Analysis 
               
               
                   
               
             
          
           
               
                 1 
                 4 
                 Therapeutic 
                 — 
                 1 st , 4 hrs 
                 Day 5 
               
               
                   
                   
                 vehicle 
                   
                 post-HDI 
               
               
                 3 
                 4 
                 Therapeutic 
                 0.4 ml/mouse 
                 1 st , 4 hrs 
                 Day 5 
               
               
                   
                   
                 RAAS 105 
                   
                 post-HDI 
               
               
                 11 
                 2 
                 Naive 
                 — 
                 — 
                 — 
               
               
                   
               
             
          
         
       
     
       Cell Populations in Peripheral Blood 
       [0136]    After removing red blood cells, T cell lineages, B cells, DCs, granulocytes, and monocytes/macrophages in peripheral blood were analyzed by FACS analysis. 
         [0137]    Total T cells and B cells were characterized by CD3 and CD19, respectively. HBV infection did not change the percentages of CD3 +  T cells compared with naïve mice. Therapeutic treatment of RAAS 105 reduced the percentages of both CD3 +  T cells and CD1913 cells significantly ( FIG. 1 ). The representative FACS profiles from each group were illustrated in  FIG. 2 . 
         [0138]      FIG. 1 . Percentages of T and B lymphocytes in peripheral blood. Total lymphocytes were gated. After therapeutic treated by RAAS 105, percentages of TB cells significantly decreased in peripheral blood. (by test) 
         [0139]      FIG. 2 . Percent of T cells and B cells in peripheral blood. Total lymphocytes were gated. 
         [0140]    Further analysis of the percentages of CD4 +  and CD8 +  (non-CD4 + ) T cell lineages were performed gating on total CD3 +  T cells. The results showed there were no differences in the percentages of CD4 +  and CD8 +  T cells among all the groups ( FIG. 3 ). The representative FACS profiles from each group were illustrated in  FIG. 4 . 
         [0141]      FIG. 3 . Percentages of CD4 and CD8 T cells in peripheral blood. Total CD3 T cells were gated and further analyzed for CD4/CD8 percentages. 
         [0142]      FIG. 4 . Percentages of CD4 and CD8 T cells in peripheral blood. Total CD3 T cells were gated. 
         [0143]    Percentages of total CD11c +  dendritic cells (DC) and Gr-1 +  granulocytes in peripheral blood were investigated. HBV infection reduced the percentages of CD11c +  DCs, a phenomenon which also be observed in human patients, whereas the percentages of Gr-1 +  granulocytes were not affected. Therapeutic treatment of RAAS 105 did not show any effect on CD11c +  DCs, but increased the percentages of Gr-1 +  granulocytes significantly ( FIG. 5 ). The representative FACS profiles from each group were illustrated in  FIG. 6 . 
         [0144]      FIG. 5 . Percents of Dendritic cells and Granulocytes in peripheral blood. Total live cells were gated. After therapeutic treatment, percents of granulocytes increased in peripheral blood (by T test) 
         [0145]      FIG. 6 . Percents of Granulocytes/Dendritic cells in peripheral blood. Total live cells were gated. 
         [0146]    Percentages of Monocytes were examined using surface marker CD11b. It increased significantly as same as Gr1+ granulocytes compared with the vehicle group ( FIG. 7 ). The representative FACS profiles from each group were illustrated in  FIG. 8 . 
         [0147]      FIG. 7 . Percentages of Monocytes in peripheral blood. Total live cells were gated. After treatment, percentages of monocytes in peripheral blood significantly increased (t test) 
         [0148]      FIG. 8 . Percentages of monocytes in peripheral blood. Total live cells were gated. 
       Cell Populations in Spleen 
       [0149]    Cell lineages in spleen including T cell lineages (CD4 + /CD8 +  T cells, naïve T cells, memory T cells and regulatory T cells), B cells, mDCs, pDCs, granulocytes and macrophages were characterized by cell surface and intracellular markers. 
         [0150]    Percentages of total T cells and B cells in spleen were investigated. Therapeutic treatment of RAAS 105 reduced the percentages of both CD3 +  T cells and CD19 +  B cells significantly ( FIG. 9 ). The representative FACS profiles from each group were illustrated in  FIG. 10 . 
         [0151]      FIG. 9 . Percentages of T and B lymphocytes in spleen. Total lymphocytes were gated. After therapeutic treatment by RAAS 105, percents of T cells and B cells significantly decreased in spleen. 
         [0152]      FIG. 10 . Percents of T cells and B cells in spleen. Total lymphocytes were gated. 
         [0153]    Further analysis of the percentages of CD4 +  (non-CD8 + ) and CD8 +  T cell lineages were performed gating on total CD3 +  T cells. There were no differences in the percentages of CD4 +  and CD8 +  T cells among all the groups ( FIG. 11 ). The representative FACS profiles from each group were illustrated in  FIG. 12 . 
         [0154]      FIG. 11 . Percentages of CD4 and CD8 T cells in spleen. Total CD3 T cells were gated and further analyzed for CD4/CD8 percentages. 
         [0155]      FIG. 12 . Percentages of CD4 and CD8 T cells in spleen. Total CD3 T cells were gated. 
         [0156]    Three T cell lineages, naïve T cells (CD44 low CD62L high ), central memory T cells (T CM s, CD44 high CD62L high ) and Effector memory T cells (T EM s, CD44 high CD62L low ), were characterized by surface markers CD44 and CD62L. Percentages of these T cell lineages in CD4 +  or CD8 +  T cells were analyzed respectively. Both in CD4 +  and CD8 +  T cells, percentages of naïve T cells and T CM s decreased and T EM s increased after the therapeutic treatment of RAAS 105, suggesting the compound may have effect to promote the transformation of T cells from naïve T cells to memory T cells in spleen ( FIGS. 13 and 15 ). The representative FACS profiles from each group were illustrated in  FIGS. 14 and 16 . 
         [0157]      FIG. 13 . T cell subsets percentages in spleen. Total CD4 T cells were gated and T cell subsets were determined. 
         [0158]      FIG. 14 . CD4 T cell subsets percentages in spleen. Total CD4 T cells were gated and T cell subsets were determined. 
         [0159]      FIG. 15 . T cell subsets percentages in spleen. Total CD8 T cells were gated and T cell subsets were determined. 
         [0160]      FIG. 16 . CD8 T cell subsets percentages in spleen. Total CD8 T cells were gated and T cell subsets were determined. 
         [0161]    Regulatory T cells (Tregs) were analyzed by cell surface staining of anti-CD4 and anti-CD25 antibodies followed by intracellular staining of anti-Foxp3 antibody. Percents of Tregs in spleen increased compared with the vehicle group ( FIG. 17 ). The representative FACS profiles from each group were illustrated in  FIG. 18 . 
         [0162]      FIG. 17 . Percentages of Foxp3 regulatory T cells in spleen. Foxp3 regulatory T cells were analyzed by intracellular staining. After treatment, the percentage of T regulate cells is increased. 
         [0163]      FIG. 18 . Percentages of regulatory T cells in spleen. Total CD4 T cells were gated. 
         [0164]    Dendritic cells, including myeloid dendritic cells (mDC, B220 − CD11c + ) and plasmacytoid dendritic cells (pDC, B220 + CD11c + ) in spleen were analyzed. No significant differences of mDCs and pDCs were observed among all groups ( FIG. 19 ). The representative FACS profiles from each group were illustrated in  FIG. 20 . 
         [0165]      FIG. 19 . Percentages of pDcs and mDcs in spleen. Total live cells were gated. There were no significant differences after compound treatment. (by t test) 
         [0166]      FIG. 20 . Percentages of mDc and pDcs in spleen. Total live cells were gated. 
         [0167]    CD11b +  macrophages and Gr-1 +  granulocytes in spleen were analyzed. There were no significant alterations among all groups in the percentages of these cell lineages in spleen, as shown in  FIG. 21 . The representative FACS profiles from each group were illustrated in  FIG. 22 . 
         [0168]      FIG. 21 . Percentages of Macrophages and Granulocytes in Spleen. Total live cells were gated. There were no significant differences after compound treatment. (by t test) 
         [0169]      FIG. 22 . Percentages of macrophages/Granulocytes in spleen. Total live cells were gated. 
       Cell Populations in Draining Lymph Nodes 
       [0170]    Cell lineages in draining lymph nodes including T cell lineages (CD4 + /CD8 +  T cells, naïve T cells, memory T cells and regulatory T cells), DCs, granulocytes and macrophages were characterized by cell surface and intracellular markers. 
         [0171]    Percentages of total T cells in lymph nodes were analyzed. HBV infection did not affect the percentages of CD3 +  T cells but therapeutic treatment of RAAS 105 reduced it significantly compared with vehicle group ( FIG. 23 ). The representative FACS profiles from each group were illustrated in  FIG. 24 . 
         [0172]      FIG. 23 . Percentages of T cells in lymph nodes. Total lymphocytes were gated. After the treatment, the percentage of T cells in the lymph nodes were significantly decreased (t test) 
         [0173]      FIG. 24 . Percentages of CD3 T cells in lymph nodes. Total lymphocytes were gated. 
         [0174]    Further analysis of the percentages of CD4 +  and CD8 +  T cell lineages were performed gating on total CD3 +  T cells. Percentages of CD4 +  T cells tended to decrease while CD8 +  T cells tended to increase, suggesting that therapeutic treatment of RAAS 105 may have effect on the ratio of CD4 + /CD8 +  T cells in lymph nodes ( FIG. 25 ). The representative FACS profiles from each group were illustrated in  FIG. 26 . 
         [0175]      FIG. 25 . Percentages of CD4 and CD8 T cells in lymph nodes. Total CD3 T cells were gated and further analyzed for CD4/CD8 percentages. After therapeutic treatment, the percentage of CD4 T cells decreased. (by t test) 
         [0176]      FIG. 26 . Percentages of CD4 and CD8 T cells in lymph nodes. Total CD3 T cells were gated and further analyzed for CD4/CD8 percentages. 
         [0177]    Three T cell lineages, naïve T cells, T CM s and T EM s were characterized by surface markers CD44 and CD62L. Percentages of these T cell lineages in CD4 +  or CD8 +  T cells were analyzed respectively. The results in lymph nodes were comparable to those in spleen. Both in CD4 +  and CD8 +  T cells, percentages of naïve T cells and T CM s decreased and T EM s increased after the therapeutic treatment of RAAS 105, suggesting the compound also have effect to promote the transformation of T cells from naïve T cells to memory T cells in lymph nodes ( FIGS. 27 and 29 ). The representative FACS profiles from each group were illustrated in  FIGS. 28 and 30 . 
         [0178]      FIG. 27 . CD4 T cell subsets percentages in lymph nodes. Total CD4 T cells were gated and T cell subsets were determined. No significant differences were found in all the groups compared to vehicle group. 
         [0179]      FIG. 28 . CD4 T cell subset percentages in lymph nodes. Total CD4 T cells were gated and T cell subsets were determined. 
         [0180]      FIG. 29 . CD8 T cell subsets percentages in lymph nodes. Total CD8 T cells were gated and T cell subsets were determined. 
         [0181]      FIG. 30 . CD8 T cell subsets percentages in lymph nodes. Total CD8 T cells were gated and T cell subsets were determined. 
         [0182]    Regulatory T cells (Tregs) were analyzed. Percentages of Tregs in lymph node slightly increased without significant differences ( FIG. 31 ). The representative FACS profiles from each group were illustrated in  FIG. 32 . 
         [0183]      FIG. 31 . Percentages of Foxp3 regulatory T cells in lymph nodes. There were no significant alterations after compound treatment 
         [0184]      FIG. 32 . Percentages of regulatory T cells in lymph nodes. Total CD4 T cells were gated. One representative profile from each group is shown. 
         [0185]    Total dendritic cells in lymph nodes were analyzed. Therapeutic treatment of RAAS 105 may reverse the reduction of DCs induced by HBV infection ( FIG. 33 ). The representative FACS profiles from each group were illustrated in  FIG. 34 . 
         [0186]      FIG. 33 . Percentages of DCs in lymph nodes. Total live cells were gated. After treatment, percents of DCs increased significantly (by t test) 
         [0187]      FIG. 34 . Percentages of DCs in lymph nodes. Total live cells were gated. 
         [0188]    CD11b +  macrophages and Gr-1 +  granulocytes in lymph nodes were analyzed. Both percentages of CD11b +  macrophages and Gr-1 +  granulocytes increased significantly ( FIG. 35 ). The representative FACS profiles from each group were illustrated in  FIG. 36 . 
         [0189]      FIG. 35 . Percentages of Macrophages and Granulocytes in lymph nodes. Total live cells were gated. Percentages of macrophages and granulocytes significantly increased in lymph node. (by t test) 
         [0190]      FIG. 36 . Percentages of Macrophages/Granulocytes in lymph nodes. Total live cells were gated. 
         [0000]    Effect of Prophylactic Treatment with RAAS 105 
       Mice Information 
       [0191]    Total 14 female BALB/c mice including 2 naïve mice at the same age were transferred from Infectious Disease (ID) Group of Wuxi Apptec. The group and the regimen information were shown by Table 2. 
         [0000]    
       
         
               
             
               
               
               
               
               
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 2 
               
             
             
               
                   
               
               
                 The experimental group and dosing regimen 
               
               
                 of the 2 nd  part of the study 
               
             
          
           
               
                   
                   
                   
                   
                 1 st  or last 
                   
               
               
                 Groups 
                 N 
                 Group ID 
                 Dose 
                 dosing 
                 Analysis 
               
               
                   
               
             
          
           
               
                 5 
                 4 
                 Prophylactic 
                 — 
                 last, 4 hrs 
                 Day 5 
               
               
                   
                   
                 vehicle #   
                   
                 pre-HDI 
               
               
                 7 
                 4 
                 Prophylactic 
                 0.4 ml/mouse 
                 last, 4 hrs 
                 Day 5 
               
               
                   
                   
                 RAAS 105 
                   
                 pre-HDI 
               
               
                 10 
                 4 
                 ETV 
                 0.1 mg/kg      
                 1 st , 4 hrs 
                 Day 5 
               
               
                   
                   
                   
                   
                 pre-HDI 
               
               
                 11 
                 2 
                 Naive 
                 — 
                 — 
                 — 
               
               
                   
               
             
          
         
       
     
       Cell Populations in Peripheral Blood 
       [0192]    After removing red blood cells, T cell lineages, B cells, DCs, granulocytes, and monocytes/macrophages in peripheral blood were analyzed by FACS analysis. 
         [0193]    Total T cells and B cells were characterized. Unlike therapeutic treatment, prophylactic treatment of RAAS 105 had no effect on percentages of CD3 +  T cells but reduced the percentages of CD19 +  B cells although the statistical significance was not found ( FIG. 37 ). The representative FACS profiles from each group were illustrated in  FIG. 38 . 
         [0194]      FIG. 37 . Percents of T and B lymphocytes in peripheral blood. Total lymphocytes were gated. 
         [0195]      FIG. 38 . Percents of T cells and B cells in peripheral blood. Total lymphocytes were gated. 
         [0196]    Further analysis of the percentages of CD4 +  and CD8 +  (non-CD4 + ) T cell lineages were performed gating on total CD3 +  T cells. Unlike therapeutic treatment, prophylactic treatment reduced percentages of CD4 +  T cells and increased percentage of CD8 +  T cells, suggesting the potential effect of RAAS 105 to reduce the ratio of CD4 + /CD8 +  T cells in peripheral blood ( FIG. 39 ). The representative FACS profiles from each group were illustrated in  FIG. 40 . 
         [0197]      FIG. 39 . Percentages of CD4 and CD8 T cells in peripheral blood. Total CD3 T cells were gated and further analyzed for CD4/CD8 percentages. After prophylactic treated by RAAS 105, percentages of CD4 T cells decreased while CD8 T cells increased (by t test) 
         [0198]      FIG. 40 . Percentages of CD4 and CD8 T cells in peripheral blood. Total CD3 T cells were gated. 
         [0199]    Results of total CD11c +  dendritic cells (DC) and Gr-1 +  granulocytes in peripheral blood were also different from those in therapeutic treatment. Prophylactic treatment of RAAS 105 reversed the reduction of DCs induced by HBV infection, but had no significant effect on granulocytes in peripheral blood ( FIG. 41 ). The representative FACS profiles from each group were illustrated in  FIG. 42 . 
         [0200]      FIG. 41 . Percentages of Dendritic cells and Granulocytes in peripheral blood. Total live cells were gated. After prophylactic treated, percents of dendritic cells increased in [eripheral blood. 
         [0201]      FIG. 42 . Percentages of Granulocytes/Dendritic cells in peripheral blood. Total live cells were gated. 
         [0202]    Percentages of Monocytes were examined. There were no significant differences among all groups ( FIG. 43 ). The representative FACS profiles from each group were illustrated in  FIG. 44 . 
         [0203]      FIG. 43 . Percentages of Monocytes in peripheral blood. Total live cells were gated. 
         [0204]      FIG. 44 . Percentages of monocytes in peripheral blood. Total live cells were gated. 
       Cell Populations in Spleen 
       [0205]    Cell lineages in spleen including T cell lineages (CD4 + /CD8 +  T cells, naïve T cells, memory T cells and regulatory T cells), B cells, mDCs, pDCs, granulocytes and macrophages were characterized by cell surface and intracellular markers. 
         [0206]    Percentages of total T cells and B cells in spleen were investigated. Unlike therapeutic treatment, prophylactic treatment did not show effects on percentages of CD3 +  T cells and CD19 +  B cells ( FIG. 45 ). The representative FACS profiles from each group were illustrated in  FIG. 46 . 
         [0207]      FIG. 45 . Percentages of T and B lymphocytes in spleen. Total lymphocytes were gated. 
         [0208]      FIG. 46 . Percentages of T and B cells in spleen. Total lymphocytes were gated. 
         [0209]    Further analysis of the percentages of CD4 +  (non-CD8 + ) and CD8 +  T cell lineages were performed gating on total CD3 +  T cells. Percentages of CD4 +  T cells slightly decreased and CD8 +  T cells slightly increased in spleen ( FIG. 47 ). The representative FACS profiles from each group were illustrated in  FIG. 48 . 
         [0210]      FIG. 47 . Percentages of CD4 and CD8 T cells in spleen. Total CD3 T cells were gated and further analyzed for CD4/CD8 percentages. After prophylactic treated by RAAS 105, the percentage of CD4 T cells slightly decreased while CD8 T cells slightly increased (by t test) 
         [0211]      FIG. 48 . Percentages of CD4 and CD8 T cells in spleen. Total CD3 T cells were gated and further analyzed for CD4/CD8 percentages. 
         [0212]    Naïve T cells, central memory T cells and Effector memory T cells were investigated. Percentages of these T cell lineages in CD4 +  or CD8 +  T cells in spleen were analyzed respectively. Both in CD4 +  and CD8 +  T cells, percentages of naïve T cells decreased and T EM s increased significantly after the prophylactic treatment of RAAS 105 ( FIGS. 49 and 51 ). The representative FACS profiles from each group were illustrated in  FIGS. 50 and 52 . 
         [0213]      FIG. 49 . T cell subset percentages in spleen. Total CD4 T cells were gated and T cell subsets were determined. 
         [0214]      FIG. 50 . T Cell subsets percentages in spleen. Total CD4 T cells were gated and T cell subsets were determined. 
         [0215]      FIG. 51 . T cell subsets percentages in spleen. Total CD8 T cells were gated and T cell subsets were determined. 
         [0216]      FIG. 52 . T cell subsets percentages in spleen. Total CD8 T cells were gated and T cell subsets were determined. 
         [0217]    Results of regulatory T cells (Tregs) were comparable with those in therapeutic treatment. Percentages of Tregs in spleen increased compared with the vehicle group by prophylactic treatment of RAAS 105 ( FIG. 53 ). The representative FACS profiles from each group were illustrated in  FIG. 54 . 
         [0218]      FIG. 53 . Percentages of Foxp3 regulatory T cells in spleen. Foxp3 regulatory T cells were analyzed by intracellular staining. 
         [0219]      FIG. 54 . Percentages of regulatory T cells in spleen. Total CD4 T cells were gated. 
         [0220]    Dendritic cells, including mDCs and pDCs in spleen were analyzed. No significant differences of mDCs and pDCs were observed among all groups after prophylactic treatment ( FIG. 55 ). The representative FACS profiles from each group were illustrated in  FIG. 56 . 
         [0221]      FIG. 55 . Percentages of pDCs and mDC in spleen. Total live cells were gated. There were no significant differences after compound treatment (by t test) 
         [0222]      FIG. 56 . Percentages of mDCs and pDCs in spleen. Total live cells were gated. 
         [0223]    CD11b +  macrophages and Gr-1 +  granulocytes in spleen were analyzed. Percentages of macrophages and granulocytes increased, but no statistical differences were observed, as shown in  FIG. 57 . The representative FACS profiles from each group were illustrated in  FIG. 58 . 
         [0224]      FIG. 57 . Percentages of Macrophages and Granulocytes in spleen. Total live cells were gated. There were no significant differences after compound treatment. (by t test) 
         [0225]      FIG. 58 . Percentages of macrophages/granulocytes in spleen. Total live cells were gated. 
       Cell Populations in Draining Lymph Nodes 
       [0226]    Cell lineages in draining lymph nodes including T cell lineages (CD4 + /CD8 +  T cells, naïve T cells, memory T cells and regulatory T cells), DCs, granulocytes and macrophages were characterized by cell surface and intracellular markers. 
         [0227]    Percentages of total T cells in lymph nodes were analyzed. Similar with therapeutic treatment, HBV infection did not affect the percentages of CD3 +  T cells but prophylactic treatment of RAAS 105 reduced it significantly compared with vehicle group ( FIG. 59 ). The representative FACS profiles from each group were illustrated in  FIG. 60 . 
         [0228]      FIG. 59 . Percentages of T cells in lymph nodes. Total lymphocytes were gated. After the treatment, percents of T cells in the lymph nodes were significantly decreased. (t test) 
         [0229]      FIG. 60 . Percentages of CD3 T cells in lymph nodes. Total lymphocytes were gated. 
         [0230]    Further analysis of the percentages of CD4 +  and CD8 +  T cell lineages were performed gating on total CD3 +  T cells. Percentages of CD4 +  T cells tended to decrease while CD8 +  T cells tended to increase after prophylactic treatment, as was seen in therapeutic treatment ( FIG. 61 ). The representative FACS profiles from each group were illustrated in  FIG. 62 . 
         [0231]      FIG. 61 . Percentages of CD4 and CD8 T cells in lymph nodes. Total CD3 T cells were gated and further analyzed for CD4/CD8 percentages. After prophylactic treatment, percents of CD4 T cells decreased (by t test) 
         [0232]      FIG. 62 . Percentages of CD4 and CD8 T cells in lymph nodes. Total CD3 T cells were gated and further analyzed for CD4/CD8 percentages. 
         [0233]    Results of naïve T cells, central memory T cells and Effector memory T cells were totally difference with those in therapeutic treatment. Prophylactic treatment did not show significant effects on naïve T cells and T CM s, but increased percentages of T EM s ( FIGS. 63 and 65 ). The representative FACS profiles from each group were illustrated in  FIGS. 64 and 66 . 
         [0234]      FIG. 63 . T cell subsets percentages in lymph nodes. Total CD4 cells were gated and T cell subsets were determined. No significant differences were found except effector memory T cells compared to vehicle group. 
         [0235]      FIG. 64 . T cell subsets percentages in lymph nodes. Total CD4 T cells were gated and T cell subsets were determined. 
         [0236]      FIG. 65 . T cell subsets percentages in lymph nodes. Total CD8 T cells were gated and T cell subsets were determined. No significant differences were found in all the groups compared to vehicle group. 
         [0237]      FIG. 66 . T cell subsets percentages in lymph nodes. Total CD8 T cells were gated and T cell subsets were determined. 
         [0238]    Regulatory T cells were analyzed. There were no significant differences among all groups ( FIG. 67 ). The representative FACS profiles from each group were illustrated in  FIG. 68 . 
         [0239]      FIG. 67 . Percentages of Foxp3 regulatory T cells in lymph nodes. Foxp3 regulatory T cells were analyzed by intracellular staining. There were no significant alterations after compound treatment. (by t test) 
         [0240]      FIG. 68 . Percentages of regulatory T cells in lymph nodes. Total CD4 T cells were gated. 
         [0241]    Results of total dendritic cells in lymph nodes were similar with those in therapeutic treatment. Prophylactic treatment of RAAS 105 also increased the percentages of DCs significantly compared with vehicle group ( FIG. 69 ). The representative FACS profiles from each group were illustrated in  FIG. 70 . 
         [0242]      FIG. 69 . Percentages of DCs in lymph nodes. Total live cells were gated. After the treatment, percentages of the DCs increased significantly (by t test) 
         [0243]      FIG. 70 . Percentages of DCs in lymph nodes. Total live cells were gated. 
         [0244]    CD11b +  macrophages and Gr-1 +  granulocytes in lymph nodes were analyzed. Both macrophages and granulocytes increased significantly ( FIG. 71 ). The representative FACS profiles from each group were illustrated in  FIG. 72 . 
         [0245]      FIG. 71 . Percentages of Macrophages and Granulocytes in lymph nodes. Total live cells were gated. After therapeutic treated by RAAS 105, percents of macrophages and granulocytes significantly increased. (by t test) 
         [0246]      FIG. 72 . Percentages of Macrophages/Granulocytes in lymph nodes. Total live cells were gated. 
       CONCLUSIONS 
       [0247]    The effects of RAAS 105 on different cell lineages in lymphoid tissues and peripheral blood in HBV infected mice were investigated by FACS analysis. T cell lineages (including CD4 + /CD8 +  T cells, naïve T cells, memory T cells and regulatory T cells), B cells, dendritic cells (including mDCs, pDCs), granulocytes and monocytes/macrophages were analyzed. RAAS 105 was administered in two different time schedules for therapeutic and prophylactic treatment. 
         [0248]    Therapeutic treatment revealed some interesting findings. The animals treated with RAAS 105 exhibited alterations in multiple immune cells and various lineages compared with that in the vehicle group, including reduction of lymphocytes and increase of granulocytes and monocytes. Prophylactic treatment led to less dramatic alterations in the immune cells.