Abstract:
Compositions and methods for enhancing an immune response with an adjuvant composition comprising: an anti-dendritic cell (DC)-specific antibody or fragment thereof conjugated to at least a portion of a TLR agonist; and a pharmaceutically acceptable carrier are disclosed herein. The conjugate and agonist are each comprised in an amount such that, in combination with the other, are effective to produce the immune response in a human or animal subject in need of immunostimulation.

Description:
CROSS-REFERENCE TO RELATED APPLICATIONS 
       [0001]    This application is a non-provisional application of U.S. provisional patent application No. 61/373,763 filed on Aug. 13, 2010 and entitled “Novel Vaccine Adjuvants Based on Targeting Adjuvants to Antibodies Directly to Antigen-Presenting Cells” the entire contents of which is incorporated herein by reference. 
     
    
     STATEMENT OF FEDERALLY FUNDED RESEARCH 
       [0002]    This invention was made with U.S. Government support under Contract Nos. 1 U19 AI057234 awarded by the National Institutes of Health (NIH)/National Institute for Allergy and Infectious Diseases (NIAID). The government has certain rights in this invention. 
     
    
     TECHNICAL FIELD OF THE INVENTION 
       [0003]    The present invention relates in general to the dendritic cell (DC)-targeting vaccines, and more particularly, to the enhancing vaccine efficacy by directly linking adjuvants (e.g., TLR ligands) directly to DC-targeting vaccines. 
       REFERENCE TO A SEQUENCE LISTING 
       [0004]    The present application includes a Sequence Listing filed separately as required by 37 CFR 1.821-1.825. 
       BACKGROUND OF THE INVENTION 
       [0005]    Without limiting the scope of the invention, its background is described in connection with novel adjuvants, dendritic cell (DC) vaccines, and strategies for enhancing immune responses to DC vaccines. 
         [0006]    U.S. Patent Application Publication No. 20090004194 (Kedl, 2007) relates to novel protein and DNA conjugates which promote antigen specific cellular immunity. The use of these polypeptide conjugates and DNA conjugates as immune adjuvants for treating various chronic diseases including cancer, infectious diseases, autoimmune diseases, allergic and inflammatory diseases. The Kedl invention discloses fusion proteins and DNA conjugates containing a TLR/CD40/agonist and optional antigen combination. The use of these protein and DNA conjugates as immune adjuvants and as vaccines for treatment of various chronic diseases is also taught. 
         [0007]    U.S. Patent Application Publication No. 20080220011 (Steven, 2008) provides a fusion protein comprising a flagellin adjuvant and a tumor antigen. Also provided are compositions comprising a flagellin adjuvant and a tumor antigen. The invention further provides pharmaceutical formulations and methods for inducing an immune response against a tumor antigen and methods of treating a tumor in a subject. 
         [0008]    U.S. Patent Application Publication No. 20080248068 (Ljunggren et al. 2008) is directed to flagellin and its use as an adjuvant for vaccination. The invention can be used in vaccine formulations to improve immunity against any other antigen administered at the same localization. The antigen can be administered in the same construct as Flagellin or in any other formulation given at the same localization. As an alternative flagellin can be used to stimulate immunity against antigens expressed at a specific location. Flagellin can also be used to induce local inflammation with the purpose of creating a model for inflammation. 
         [0009]    U.S. Pat. No. 7,404,963 issued to Sotomayor and Suarez (2008) provides adjuvants, vaccines, and related methods that are useful in eliciting immune responses, particularly immune responses against tumor antigens. According to the Sotomayor invention flagellin is capable of inhibiting tolerance when it is administered in conjunction with a tolerogenic antigen. This effect is likely mediated by the ability of flagellin to induce IL-12 while keeping IL-10 levels low. Furthermore, flagellin can be provided in an extended-releasing manner by using a flagellin-expressing cell. Preferably, the flagellin-expressing cell is treated such that it is no longer capable of replicating, yet retaining the ability to express flagellin, such as by lethal irradiation. 
       SUMMARY OF THE INVENTION 
       [0010]    The present invention describes compositions and methods for making novel vaccine adjuvants based on targeting adjuvants with antibodies directly to antigen-presenting cells. The present invention was found to enhance vaccine efficacy by linking adjuvants (e.g., TLR ligands) directly to DC-targeting vaccines. As shown herein, the compositions and methods of the present invention are broadly applicable to all DC-targeting vaccines and extensible to making adjuvants with unexpected novel properties. 
         [0011]    The present invention in one embodiment discloses an adjuvant composition comprising an anti-dendritic cell (DC)-specific antibody or binding fragment thereof conjugated to a TLR agonist; and at least one antigen, wherein the antigen and the agonist are effective to produce an immune response in a human or animal subject in need of immunostimulation. 
         [0012]    The DC-specific antibody or fragment described hereinabove is selected from an anti-DCIR, MHC class I, MHC class II, CD1, CD2, CD3, CD4, CD8, CD11b, CD14, CD15, CD16, CD19, CD20, CD29, CD31, CD40, CD43, CD44, CD45, CD54, CD56, CD57, CD58, CD83, CD86, CMRF-44, CMRF-56, DCIR, DC-ASPGR, CLEC-6, CD40, BDCA-2, MARCO, DEC-205, mannose receptor, Langerin, DECTIN-1, B7-1, B7-2, IFN-γ receptor and IL-2 receptor, ICAM-1, Fcγ receptor, LOX-1, or ASPGR. In one aspect, the composition described above further comprises antigenic peptides selected from human immunodeficiency virus (HIV) antigens and gene products selected from the group consisting of gag, pol, and env genes, the Nef protein, reverse transcriptase, string of HIV peptides (Hipo5), PSA (KLQCVDLHV)-tetramer, a HIVgag-derived p24-PLA HIV gag p24 (gag), and other HIV components, hepatitis viral antigens, influenza viral antigens and peptides selected from the group consisting of hemagglutinin, neuraminidase, Influenza A Hemagglutinin HA-1 from a H1N1 Flu strain, HLA-A201-FluMP (58-66) peptide (GILGFVFTL) tetramer, and Avian Flu (HA5-1), dockerin domain from  C. thermocellum , measles viral antigens, rubella viral antigens, rotaviral antigens, cytomegaloviral antigens, respiratory syncytial viral antigens, herpes simplex viral antigens, varicella zoster viral antigens, Japanese encephalitis viral antigens, rabies viral antigens or combinations and modifications thereof. In another aspect the composition further comprises antigenic peptides selected from one or more bacterial antigens, wherein the bacterial antigens comprise antigens derived from  Bacillus, Escherichia, Listeria, Neisseria, Nocardia, Salmonella, Staphylococcus, Streptococcus , or combinations and modifications thereof. 
         [0013]    In yet another aspect the composition further comprises antigenic peptides selected from cancer peptides selected from tumor associated antigens comprising antigens from leukemias and lymphomas, neurological tumors such as astrocytomas or glioblastomas, melanoma, breast cancer, lung cancer, head and neck cancer, gastrointestinal tumors, gastric cancer, colon cancer, liver cancer, pancreatic cancer, genitourinary tumors such cervix, uterus, ovarian cancer, vaginal cancer, testicular cancer, prostate cancer or penile cancer, bone tumors, vascular tumors, or cancers of the lip, nasopharynx, pharynx and oral cavity, esophagus, rectum, gall bladder, biliary tree, larynx, lung and bronchus, bladder, kidney, brain and other parts of the nervous system, thyroid, Hodgkin&#39;s disease, non-Hodgkin&#39;s lymphoma, multiple myeloma and leukemia. In a specific aspect the tumor associated antigens are selected from CEA, prostate specific antigen (PSA), HER-2/neu, BAGE, GAGE, MAGE 1-4, 6 and 12, MUC (Mucin) (e.g., MUC-1, MUC-2, etc.), GM2 and GD2 gangliosides, ras, myc, tyrosinase, MART (melanoma antigen), MARCO-MART, cyclin B1, cyclin D, Pmel 17(gp100), GnT-V intron V sequence (N-acetylglucoaminyltransferase V intron V sequence), Prostate Ca psm, prostate serum antigen (PSA), PRAME (melanoma antigen), β-catenin, MUM-1-B (melanoma ubiquitous mutated gene product), GAGE (melanoma antigen) 1, BAGE (melanoma antigen) 2-10, c-ERB2 (Her2/neu), EBNA (Epstein-Barr Virus nuclear antigen) 1-6, gp75, human papilloma virus (HPV) E6 and E7, p53, lung resistance protein (LRP), Bcl-2, and Ki-67. 
         [0014]    In other aspects related to the composition of the present invention DC-specific antibody is humanized. In another aspect the TLR agonist comprises at least one of a flagellin from  Salmonella enterica , a flagellin from  Vibrio cholerae , any other TLR5 agonist, a TLR7 agonist, a TLR9 agonist, or any combinations or modifications thereof. In yet another aspect the antigen is conjugated to the antibody and TLR agonist. In another aspect the antigen and the antibody are a single fusion protein. In another aspect the antibody comprises at least one of a light chain, a heavy chain, or a heavy and a light chain. 
         [0015]    The present invention in another embodiment provides a vaccine composition comprising: (i) an antigen and (ii) an adjuvant, wherein the adjuvant comprises an anti-dendritic cell (DC)-specific antibody or fragment thereof conjugated to at least a portion of a TLR agonist in an amount effective to produce an immune response in a human or animal subject in need of immunostimulation. The DC-specific antibody or fragment used in the vaccine hereinabove is selected from an anti-DCIR, MHC class I, MHC class II, CD1, CD2, CD3, CD4, CD8, CD11b, CD14, CD15, CD16, CD19, CD20, CD29, CD31, CD40, CD43, CD44, CD45, CD54, CD56, CD57, CD58, CD83, CD86, CMRF-44, CMRF-56, DCIR, DC-ASPGR, CLEC-6, CD40, BDCA-2, MARCO, DEC-205, mannose receptor, Langerin, DECTIN-1, B7-1, B7-2, IFN-γ receptor and IL-2 receptor, ICAM-1, Fcγ receptor, LOX-1, or ASPGR. The vaccine composition further comprises antigenic peptides selected. Non-limiting examples of antigenic peptides that may be used in the vaccine composition of the present invention have been previously described in paragraph [0012]. The vaccine composition further comprises antigenic peptides selected from one or more bacterial antigens. A list of non-limiting bacterial antigens that may be used is found in paragraph [0012]. In another aspect the vaccine further comprises antigenic peptides selected from cancer peptides selected from tumor associated antigens comprising antigens previously described in paragraph [0013]. 
         [0016]    In yet another aspect the composition further comprises antigenic peptides selected from tumor associated antigens selected from CEA, prostate specific antigen (PSA), HER-2/neu, BAGE, GAGE, MAGE 1-4, 6 and 12, MUC (Mucin) (e.g., MUC-1, MUC-2, etc.), GM2 and GD2 gangliosides, ras, myc, tyrosinase, MART (melanoma antigen), MARCO-MART, cyclin B1, cyclin D, Pmel 17(gp100), GnT-V intron V sequence (N-acetylglucoaminyltransferase V intron V sequence), Prostate Ca psm, prostate serum antigen (PSA), PRAME (melanoma antigen), β-catenin, MUM-1-B (melanoma ubiquitous mutated gene product), GAGE (melanoma antigen) 1, BAGE (melanoma antigen) 2-10, c-ERB2 (Her2/neu), EBNA (Epstein-Barr Virus nuclear antigen) 1-6, gp75, human papilloma virus (HPV) E6 and E7, p53, lung resistance protein (LRP), Bcl-2, and Ki-67. In one aspect the DC-specific antibody is humanized. In another aspect the TLR agonist comprises at least one of a flagellin from  Salmonella enterica , a flagellin from  Vibrio cholerae , any other TLR5 agonist, a TLR7 agonist, a TLR9 agonist, or any combinations or modifications thereof. In yet another aspect the antigen is conjugated to the antibody and TLR agonist. In another aspect the antigen and the antibody are a single fusion protein. In yet another aspect the antibody comprises at least one of a light chain, a heavy chain, or a heavy and a light chain. 
         [0017]    In yet another embodiment the instant invention discloses a method for increasing effectiveness of antigen presentation by an antigen presenting cell comprising: contacting the antigen presenting cell with a composition comprising: (i) an antigen; and (ii) an adjuvant, wherein the adjuvant comprises an anti-dendritic cell (DC)-specific antibody or binding fragment thereof conjugated to a TLR agonist, wherein the antigen and adjuvant are provided in an amount effective to produce an immune response in a human or animal subject in need of immunostimulation. Ex vivo methods of increasing effectiveness of antigen presentation by antigen presenting cells have been previously described in U.S. Patent Application Publication No. 20100135994 (Banchereau et al. 2010) and in U.S. patent application Ser. No. 13/100,684 (Banchereau et al. 2011), relevant portions of which are incorporated herein by reference. 
         [0018]    In one aspect the DC-specific antibody or fragment is selected from an anti-DCIR, MHC class I, MHC class II, CD1, CD2, CD3, CD4, CD8, CD11b, CD14, CD15, CD16, CD19, CD20, CD29, CD31, CD40, CD43, CD44, CD45, CD54, CD56, CD57, CD58, CD83, CD86, CMRF-44, CMRF-56, DCIR, DC-ASPGR, CLEC-6, CD40, BDCA-2, MARCO, DEC-205, mannose receptor, Langerin, DECTIN-1, B7-1, B7-2, IFN-γ receptor and IL-2 receptor, ICAM-1, Fcγ receptor, LOX-1, or ASPGR. In a related aspect the anti-DC-specific antibody is selected from pairs of SEQ ID NOS.: 7 and 9, 11 and 13, 15 and 17, 19 and 21, 23 and 25, 27 and 29, 31 and 33, 35 and 37, 39 and 41, 43 and 45, 47 and 49, 51 and 53, 55 and 57, 59 and 61, 63 and 65, 67 and 69, 71 and 73, 75 and 77, 79 and 81, 83 and 85, 87 and 89, 91 and 93, 95 and 97, 99 and 101, 1-3 and 105, 107 and 109, 111 and 113, 115 and 117, 119 and 121, 123 and 125, 127 and 129, 131 and 132, 133 and 134. 
         [0019]    In one aspect the composition further comprises antigenic peptides, non-limiting examples of the antigenic peptides have been described previously. In another aspect the composition further comprises antigenic peptides selected from cancer peptides as previously described. The antigenic peptides are selected from tumor associated antigens. Non-limiting examples of tumor associated antigens are described herein. 
         [0020]    In related aspects of the method the DC-specific antibody is humanized and the composition is administered to the human or animal subject by an oral route, a nasal route, topically or as an injection (the injection is selected from intradermal, intramucosal, subcutaneous, intravenous, intraperitoneal, intramuscular, and intravenous injections). In one aspect the TLR agonist comprises at least one of a flagellin from  Salmonella enterica , a flagellin from  Vibrio cholerae , any other TLR5 agonist, a TLR7 agonist, a TLR9 agonist, or any combinations or modifications thereof. In another aspect the antigen is conjugated to the antibody and TLR agonist. In yet another aspect the antigen and the antibody are a single fusion protein. In another aspect the antibody comprises at least one of a light chain, a heavy chain, or a heavy and a light chain. 
         [0021]    The present invention further provides a method for a treatment, a prophylaxis or a combination thereof against one or more cancers in a human subject comprising the steps of: (i) identifying the human subject in need of the treatment, the prophylaxis or a combination thereof against the one or more cancers and (ii) administering a vaccine composition comprising: a) an antigen and b) an adjuvant, wherein the adjuvant comprises an anti-dendritic cell (DC)-specific antibody or fragment thereof conjugated to a TLR agonist; and a pharmaceutically acceptable carrier, wherein the antigen and adjuvant are provided in an amount effective to produce an immune response for the treatment, the prophylaxis or a combination thereof against the one or more cancers. 
         [0022]    Another embodiment of the present invention relates to a method of providing immunostimulation by activation of one or more dendritic cells (DCs) to a human subject for a prophylaxis, a therapy or a combination thereof against one or more viral, bacterial, fungal, parasitic, protozoal, and parasitic diseases, and allergic disorders comprising the steps of: i) identifying the human subject in need of immunostimulation for the prophylaxis, the therapy or a combination thereof against the one or more viral, bacterial, fungal, parasitic, protozoal, and parasitic diseases, and allergic disorders; ii) isolating one or more DCs from the human subject; iii) activating the isolated DCs with an amount of a composition effective for forming activated DCs comprising: a) an antigen and b) an adjuvant, wherein the adjuvant comprises an anti-dendritic cell (DC)-specific antibody or fragment thereof conjugated to a TLR agonist; and a pharmaceutically acceptable carrier, in an amount effective to produce an immune response in a human or animal subject in need of immunostimulation; and iv) reintroducing the activated DCs into the human subject. 
         [0023]    In yet another embodiment the instant invention discloses an adjuvant composition comprising an anti-dendritic cell (DC)-specific antibody or fragment thereof conjugated to at least a portion of a TLR agonist wherein the anti-DC-specific antibody is selected from pairs of SEQ ID NOS.: 7 and 9, 11 and 13, 15 and 17, 19 and 21, 23 and 25, 27 and 29, 31 and 33, 35 and 37, 39 and 41, 43 and 45, 47 and 49, 51 and 53, 55 and 57, 59 and 61, 63 and 65, 67 and 69, 71 and 73, 75 and 77, 79 and 81, 83 and 85, 87 and 89, 91 and 93, 95 and 97, 99 and 101, 1-3 and 105, 107 and 109, 111 and 113, 115 and 117, 119 and 121, 123 and 125, 127 and 129, 131 and 132, 133 and 134. 
         [0024]    In one aspect of the adjuvant composition hereinabove the composition further comprises antigenic peptides selected from human immunodeficiency virus (HIV) antigens and gene products selected from the group consisting of gag, pol, and env genes, the Nef protein, reverse transcriptase, string of HIV peptides (Hipo5), PSA (KLQCVDLHV)-tetramer, a HIVgag-derived p24-PLA HIV gag p24 (gag), and other HIV components, hepatitis viral antigens, influenza viral antigens and peptides selected from the group consisting of hemagglutinin, neuraminidase, Influenza A Hemagglutinin HA-1 from a H1N1 Flu strain, HLA-A201-FluMP (58-66) peptide (GILGFVFTL) tetramer, and Avian Flu (HA5-1), dockerin domain from  C. thermocellum , measles viral antigens, rubella viral antigens, rotaviral antigens, cytomegaloviral antigens, respiratory syncytial viral antigens, herpes simplex viral antigens, varicella zoster viral antigens, Japanese encephalitis viral antigens, rabies viral antigens or combinations and modifications thereof. 
         [0025]    In another aspect the composition further comprises antigenic peptides selected from cancer peptides selected from tumor associated antigens comprising antigens from leukemias and lymphomas, neurological tumors such as astrocytomas or glioblastomas, melanoma, breast cancer, lung cancer, head and neck cancer, gastrointestinal tumors, gastric cancer, colon cancer, liver cancer, pancreatic cancer, genitourinary tumors such cervix, uterus, ovarian cancer, vaginal cancer, testicular cancer, prostate cancer or penile cancer, bone tumors, vascular tumors, or cancers of the lip, nasopharynx, pharynx and oral cavity, esophagus, rectum, gall bladder, biliary tree, larynx, lung and bronchus, bladder, kidney, brain and other parts of the nervous system, thyroid, Hodgkin&#39;s disease, non-Hodgkin&#39;s lymphoma, multiple myeloma and leukemia. In yet another aspect the composition further comprises antigenic peptides selected from tumor associated antigens selected from CEA, prostate specific antigen (PSA), HER-2/neu, BAGE, GAGE, MAGE 1-4, 6 and 12, MUC (Mucin) (e.g., MUC-1, MUC-2, etc.), GM2 and GD2 gangliosides, ras, myc, tyrosinase, MART (melanoma antigen), MARCO-MART, cyclin B1, cyclin D, Pmel 17(gp100), GnT-V intron V sequence (N-acetylglucoaminyltransferase V intron V sequence), Prostate Ca psm, prostate serum antigen (PSA), PRAME (melanoma antigen), β-catenin, MUM-1-B (melanoma ubiquitous mutated gene product), GAGE (melanoma antigen) 1, BAGE (melanoma antigen) 2-10, c-ERB2 (Her2/neu), EBNA (Epstein-Barr Virus nuclear antigen) 1-6, gp75, human papilloma virus (HPV) E6 and E7, p53, lung resistance protein (LRP), Bcl-2, and Ki-67. In a specific aspect the DC-specific antibody is humanized. In other related aspects the TLR agonist comprises at least one of a flagellin from  Salmonella enterica , a flagellin from  Vibrio cholerae , any other TLR5 agonist, a TLR7 agonist, a TLR9 agonist, or any combinations or modifications thereof and the antigen and the antibody are a single fusion protein. In another aspect the antibody comprises at least one of a light chain, a heavy chain, or a heavy and a light chain. 
     
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         [0026]    For a more complete understanding of the features and advantages of the present invention, reference is now made to the detailed description of the invention along with the accompanying figures and in which: 
           [0027]      FIGS. 1A-1D  show flagellin and the several antibody-flagellin constructs of the present invention:  FIG. 1A  Residues from the conserved N-terminal and C-terminal regions are together sufficient to activate TLR5—central residues are expendable for this function,  FIG. 1B  An example of a active configuration of flagellin fused directly to a DC-targeting antibody to direct the activation properties of the flagellin fragment specifically to cells expressing the particular DC receptor and combining immunostimulatory properties of the flagellin with those of the anti-DC receptor antibody,  FIG. 1C  A variant of  1 B wherein fragments of the two conserved flagellin domains are separated by a linker or antigen sequence—in the example given in  FIG. 3A , this configuration with a particular linker sequence is not active,  FIG. 1D  A variant of  FIG. 1A  wherein an antigen or protein-protein interaction domain (dockerin in this case) is directly linked between the flagellin and antibody domains.  FIGS. 3 and 4  show examples of immune stimulation by such a variant. 
           [0028]      FIG. 2  shows the design of the studies used to test the activity of the antibody-flagellin constructs of the present invention; 
           [0029]      FIGS. 3A to 3C  show the secretion of IL-6 when various types of cells were activated with the constructs of the present invention; 
           [0030]      FIGS. 4A to 4D  show the dose titration of the various constructs as measured by the secretion of IL-6 and IL-1 beta. The data demonstrate that the immune stimulation by the flagellin fragments becomes dependent upon DC receptor interaction (in this case LOX-1) mediated by the DC-targeting antibody portion of the construct—a control hIgG4-flagellin construct is only active at much higher concentrations. Other controls show that it is the direct fusion of the flagellin fragments to the DC-targeting antibody that accounts for the enhanced immunostimulatory potency; and 
           [0031]      FIG. 5  shows heat maps of gene expression for the listed genes using an anti-LOX-1 antibody with or without linked flagellin. The exact combination of up-regulated immune stimulatory molecules will vary with different anti-DC receptor antibody constructs linked to the flagellin fragment because different combinations of target cells will be engaged and there will be different combinations of signaling via the flagellin and the DC-targeting antibody. 
       
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
       [0032]    While the making and using of various embodiments of the present invention are discussed in detail below, it should be appreciated that the present invention provides many applicable inventive concepts that can be embodied in a wide variety of specific contexts. The specific embodiments discussed herein are merely illustrative of specific ways to make and use the invention and do not delimit the scope of the invention. 
         [0033]    To facilitate the understanding of this invention, a number of terms are defined below. Terms defined herein have meanings as commonly understood by a person of ordinary skill in the areas relevant to the present invention. Terms such as “a”, “an,” and “the” are not intended to refer to only a singular entity, but include the general class of which a specific example may be used for illustration. The terminology herein is used to describe specific embodiments of the invention, but their usage does not delimit the invention, except as outlined in the claims. 
         [0034]    As used herein the term “Antigen Presenting Cells” (APC) are cells that are capable of activating T cells, and include, but are not limited to, certain macrophages, B cells and dendritic cells. “Dendritic cells” (DCs) refers to any member of a diverse population of morphologically similar cell types found in lymphoid or non-lymphoid tissues. These cells are characterized by their distinctive morphology, high levels of surface MHC-class II expression (Steinman, et al., Ann. Rev. Immunol. 9:271 (1991); incorporated herein by reference for its description of such cells). These cells can be isolated from a number of tissue sources, and conveniently, from peripheral blood, as described herein. Dendritic cell binding proteins refers to any protein for which receptors are expressed on a dendritic cell. Examples include GM-CSF, IL-1, TNF, IL-4, CD40L, CTLA4, CD28, and FLT-3 ligand. 
         [0035]    For the purpose of the present invention, the term “vaccine composition” is intended to mean a composition which can be administered to humans or to animals in order to induce an immune system response; this immune system response can result in a production of antibodies or simply in the activation of certain cells, in particular antigen-presenting cells, T lymphocytes and B lymphocytes. The vaccine composition can be a composition for prophylactic purposes or for therapeutic purposes, or both. As used herein, the term “antigen” refers to any antigen that can be used in a vaccine, whether it involves a whole microorganism or a portion thereof, and various types: (e.g., peptide, protein, glycoprotein, polysaccharide, glycolipid, lipopeptide, etc). They may be viral antigens, bacterial antigens, or the like; the term “antigen” also comprises the polynucleotides, the sequences of which are chosen so as to encode the antigens whose expression by the individuals to which the polynucleotides are administered is desired, in the case of the immunization technique referred to as DNA immunization. They may also be a set of antigens, in particular in the case of a multivalent vaccine composition which comprises antigens capable of protecting against several diseases, and which is then generally referred to as a vaccine combination, or in the case of a composition which comprises several different antigens in order to protect against a single disease, as is the case for certain vaccines against whooping cough or the flu, for example. The term “antibodies” refers to immunoglobulins, whether natural or partially or wholly produced artificially, e.g. recombinant. An antibody may be monoclonal or polyclonal. The antibody may, in some cases, be a member of one, or a combination immunoglobulin classes, including: IgG, IgM, IgA, IgD, and IgE. 
         [0036]    The terms “adjuvant” or “immunoadjuvant” may be used interchangeably and refer to a substance that enhances, augments or potentiates the host&#39;s immune response to an antigen, e.g., an antigen that is part of a vaccine. Non-limiting examples of some commonly used vaccine adjuvants include insoluble aluminum compounds, calcium phosphate, liposomes, Virosomes™, ISCOMS®, microparticles (e.g., PLG), emulsions (e.g., MF59, Montanides), virus-like particles &amp; viral vectors. Flagellin, a TLR5 agonist from  Salmonella entericum  is used as an adjuvant in the present invention. It will be understood that flagellin from other bacterial sources (e.g.,  Vibrio cholerae ) may also be used, other TLR5 agonists, TLR7 agonists, TLR9 agonists, or any combinations or modifications thereof may also be used. 
         [0037]    The term “conjugate” as used herein refers to any substance formed from the joining together of two parts. Representative conjugates in accordance with the present invention include those formed by joining together of the antigen with the antibody and the TLR agonist. The term “conjugation” refers to the process of forming the conjugate and is usually done by physical coupling, e.g. covalent binding, co-ordination covalent, or secondary binding forces, e.g. Van der Waals bonding forces. The process of linking the antigen to the antibody and the TLR agonist can also be done via a non-covalent association such as a dockerin-cohesin association (as described in U.S. Patent Publication No. 20100135994, Banchereau et al. relevant portions incorporated herein by reference) or by a direct chemical linkage by forming a peptide or chemical bond. 
         [0038]    As used herein, the term “flagellin” refers to a flagellin protein from any source including, but not limited to, any bacterial species. The flagellin may be from a species of  Salmonella  ( Salmonella enterica  as exemplified herein) or from other species of bacteria (for e.g.  Vibrio cholerae ). Also specifically contemplated are fragments, variants, analogs, homologs, or derivatives of said flagellin, and combinations thereof. The various fragments, variants, analogs, homologs or derivatives described herein may be 50%, 55%, 60%, 65%, 70%, 75%, 80%, 85%, 90%, 95%, 97%, 98%, or 99% identical to a wild-type flagellin from a specific bacterial species, e.g.,  Salmonella.    
         [0039]    The term “gene” is used to refer to a functional protein, polypeptide or peptide-encoding unit. As will be understood by those in the art, this functional term includes genomic sequences, cDNA sequences, or fragments or combinations thereof, as well as gene products, including those that may have been altered by the hand of man. Purified genes, nucleic acids, protein and the like are used to refer to these entities when identified and separated from at least one contaminating nucleic acid or protein with which it is ordinarily associated 
         [0040]    As used herein, the term “nucleic acid” or “nucleic acid molecule” refers to polynucleotides, such as deoxyribonucleic acid (DNA) or ribonucleic acid (RNA), oligonucleotides, fragments generated by the polymerase chain reaction (PCR), and fragments generated by any of ligation, scission, endonuclease action, and exonuclease action. Nucleic acid molecules can be composed of monomers that are naturally-occurring nucleotides (such as DNA and RNA), or analogs of naturally-occurring nucleotides (e.g., α-enantiomeric forms of naturally-occurring nucleotides), or a combination of both. Modified nucleotides can have alterations in sugar moieties and/or in pyrimidine or purine base moieties. Sugar modifications include, for example, replacement of one or more hydroxyl groups with halogens, alkyl groups, amines, and azido groups, or sugars can be functionalized as ethers or esters. Moreover, the entire sugar moiety can be replaced with sterically and electronically similar structures, such as aza-sugars and carbocyclic sugar analogs. Examples of modifications in a base moiety include alkylated purines and pyrimidines, acylated purines or pyrimidines, or other well-known heterocyclic substitutes. Nucleic acid monomers can be linked by phosphodiester bonds or analogs of such linkages. 
         [0041]    Analogs of phosphodiester linkages include phosphorothioate, phosphorodithioate, phosphoroselenoate, phosphorodiselenoate, phosphoroanilothioate, phosphoranilidate, phosphoramidate, and the like. The term “nucleic acid molecule” also includes so-called “peptide nucleic acids,” which comprise naturally-occurring or modified nucleic acid bases attached to a polyamide backbone. Nucleic acids can be either single stranded or double stranded. 
         [0042]    As used in this application, the term “amino acid” means one of the naturally occurring amino carboxylic acids of which proteins are comprised. The term “polypeptide” as described herein refers to a polymer of amino acid residues joined by peptide bonds, whether produced naturally or synthetically. Polypeptides of less than about 10 amino acid residues are commonly referred to as “peptides.” A “protein” is a macromolecule comprising one or more polypeptide chains. A protein may also comprise non-peptidic components, such as carbohydrate groups. Carbohydrates and other non-peptidic substituents may be added to a protein by the cell in which the protein is produced, and will vary with the type of cell. Proteins are defined herein in terms of their amino acid backbone structures; substituents such as carbohydrate groups are generally not specified, but may be present nonetheless. 
         [0043]    As used herein, the term “in vivo” refers to being inside the body. The term “in vitro” used as used in the present application is to be understood as indicating an operation carried out in a non-living system. 
         [0044]    As used herein, the term “treatment” or “treating” means any administration of a compound of the present invention and includes (1) inhibiting the disease in an animal that is experiencing or displaying the pathology or symptomatology of the diseased (i.e., arresting further development of the pathology and/or symptomatology), or (2) ameliorating the disease in an animal that is experiencing or displaying the pathology or symptomatology of the diseased (i.e., reversing the pathology and/or symptomatology). 
         [0045]    The present invention describes novel vaccine adjuvants based on targeting adjuvants with antibodies directly to antigen-presenting cells. The present invention was found to enhance vaccine efficacy by directly linking adjuvants (e.g., TLR ligands) directly to DC-targeting vaccines. As shown herein, the compositions and methods of the present invention are broadly applicable to all DC-targeting vaccines and extensible to making adjuvants with unexpected novel properties. While antigens directly linked to adjuvants (e.g., TLR&#39;s) are well known—e.g., development of Hep B vaccine linked to CpG (Dynavax) or Flu antigens linked to flagellin (Vaxigen). The present invention is an adjuvant that is directly linked to a DC-targeting vaccine (e.g., anti-DC receptor antibody fused to antigen). Several aspects of the present invention have advantages over the prior art, including dose-sparing (by sending the adjuvant directly to the antigen-presenting cell that actually receives antigen), unexpectedly, this discovery provides a method of making the agonist activity of the adjuvant strictly dependent upon the type of DC receptor targeted. 
         [0046]    Compositions and methods described herein can be used in a prophylaxis, a therapy or a combination thereof against one or more viral, bacterial, fungal, parasitic, protozoal, and parasitic diseases, allergic disorders, and cancers. Non-limiting examples of diseases against which a prophylaxis, a therapy, alleviation of symptoms or combinations thereof can be achieved using the composition of the present invention include HIV infections, hepatitis, influenza, avian flu, herpes, genitourinary, prostate, and neurological tumors, arthritis, asthma, eczema, bacterial infections selected from anthrax, cholecystitis, bacteremia, cholangitis, urinary tract infection (UTI), listeriosis, meningococcal infections, salmonellosis, necrotizing fasciitis and streptococcal toxic shock syndrome, pneumonia, skin infections, or any combinations or modifications thereof. 
         [0047]    Flagellin from  Salmonella enterica  has been exemplified in the present invention. However, a skilled artisan will understand that flagellin from many bacterial species (for e.g.,  Vibrio cholerae ) can be substituted for the flagellin that is used herein. In addition to flagellin other TLR5 agonists may also be used. For extending the invention to other TLRs, it may be necessary to employ chemical linkages since some or all of the other known TLR ligands are non-protein. Some agonists like TLR7 and TLR9, are well described chemical entities and methods to link them to proteins, while maintaining their intrinsic TLR agonistic properties, have benne previously described. For some other agonists active compounds are known, but their protein-linking chemistries are not well described 
         [0048]    Compositions and method described hereinabove use TLR agonists conjugated an anti-dendritic cell (DC)-specific antibody or binding fragment thereof. However, a skilled artisan will recognize that other non-TLR based ligands, agonists, or other moieties (for e.g. infammasome) may be conjugated to the antibody to achieve the desired in vivo or ex vivo effects. 
         [0049]    It will be understood by the skilled artisan that the composition comprising the antigen-TLR agonist-antibody, may have different possible arrangements for the individual species or moieties. For example, the TLR agonist (or flagellin as used herein) may be linked to the heavy chain (ANTIBODY L CHAIN-ANTIGEN+H CHAIN-TLR AGONIST or the light-chain (ANTIBODY H CHAIN-ANTIGEN+L CHAIN-TLR AGONIST or ANTIBODY H CHAIN-ANTIGEN-TLR AGONIST+L CHAIN) of the anti-dendritic cell (DC)-specific antibody. The conjugate may also be prepared by linking the TLR agonist/flagellin through a dockerin-cohesin attachment (for e.g. ANTIBODY H CHAIN-ANTIGEN-DOCKERIN:COHESIN-FLGN). It will be understood that the flagellin used herein may be substituted or replaced by any TLR agonist that may be linked by similar chemical or physical methods. The present invention may also include the combination wherein the antigen and the antibody are a single fusion protein. 
         [0000]    
       
         
               
               
             
           
               
                 DC-targeting linked adjuvant attachment A (SEQ ID NO: 1): Vector C959 encodes rAB- 
                   
               
               
                 pIRES2[mAnti-DCIR_9E8_H-LV-hIgG4H-C-Flex-v1-Flgn-1-Flgn-2]. 
               
               
                 QVTLKESGPGILQPSQTLSLTCSFSGFSLSTSGMGLSWIRQPSGKGLEWLAHIYWDDDKRY 
               
               
                   
               
               
                 NPSLKSRLTISKDTSSNQVFLKITIVDTADAATYYCARSSHYYGYGYGGYFDVWGAGTTV 
               
               
                   
               
               
                 TVSSAKTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVL 
               
               
                   
               
               
                 QSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFEGGPS 
               
               
                   
               
               
                 VFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNST 
               
               
                   
               
               
                 YRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMT 
               
               
                   
               
               
                 KNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQE 
               
               
                   
               
               
                 GNVFSCSVMHEALHNHYTQKSLSLSLGK           QTPTNTISVTPTNNSTPTNNSNPKPNP             IERL   
               
               
                   
               
               
                 
                   SSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALNEINNNLQR 
                 
               
               
                   
               
               
                 
                   VRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVKVLAQDNTLTIQVG 
                 
               
               
                   
               
               
                 
                   ANDGETIDIDLKQINSQTLGLDSLNVQ 
                           
                   QPELAEAAAKTTENPLQKIDAALAQVDALRS 
                 
               
               
                   
               
               
                   DLGAVQNRFNSAITNLGNTVNNLSEARSRIEDSDYATEVSNMSRAQILQ AS 
               
             
          
         
       
     
         [0050]    Bold is the N-terminal part of phase-2 flagellin [ Salmonella enterica ] gb|AAL30512.1|AF425736 — 1 residues 14-161. 
         [0051]    Underlined is the C-terminal part of phase-2 flagellin [ Salmonella enterica ] gb|AAL30512.1|AF425736 — 1 residues 405-484. 
         [0052]    Italics is a flexible linker sequence from gb|AAT79550.1| cellulosomal anchoring scaffoldin B precursor [ Bacteroides  cellulosolvens]. 
         [0053]    The amino terminus up to the first AS sequence is the heavy chain of mouse Anti-DCIR — 9E8 variable region fused to −hIgG4H constant region. AS sequences in bold-italics are joining sequences from construction of the expression vector. 
         [0054]    When co-transfected with appropriate L chain expression vector into mammalian cells (e.g., CHO—S cells) this vector directs efficient secretion of a typical embodiment of a DC-targeting agent linked to a flagellin-based adjuvant. 
         [0000]    
       
         
               
               
             
               
               
             
               
               
             
           
               
                 C1099 encodes mouse Anti-DCIR_9E8_H-LV-hIgG4H-C-Dockerin-v2-Flgn-1-Flgn-2]. 
                   
               
             
          
           
               
                 (SEQ ID NO: 2) 
                   
               
             
          
           
               
                 QVTLKESGPGILQPSQTLSLTCSFSGFSLSTSGMGLSWIRQPSGKGLEWLAHIYWDDDKRY 
                   
               
               
                   
               
               
                 NPSLKSRLTISKDTSSNQVFLKITIVDTADAATYYCARSSHYYGYGYGGYFDVWGAGTTV 
               
               
                   
               
               
                 TVSSAKTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVL 
               
               
                   
               
               
                 QSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFEGGPS 
               
               
                   
               
               
                 VFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNST 
               
               
                   
               
               
                 YRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMT 
               
               
                   
               
               
                 KNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQE 
               
               
                   
               
               
                 GNVFSCSVMHEALHNHYTQKSLSLSLGK           SEDTQPPAPTLIGDVNADGKIDSTDLTLLKRYL   
               
               
                   
               
               
                 
                   LRSATLTEEKILNADTDGNGTVNSTDLNYLKKYILRVISVFPAEGNKPPTPTPTKTPVATPSPTQPL 
                 
               
               
                   
               
               
                 
                   FTPSFKDVT 
                           
                   IERLSSGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTT 
                 
               
               
                   
               
               
                 
                   EGALNEINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQFNGVK 
                 
               
               
                   
               
               
                 
                   VLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDSLNVQ 
                           
                   QPELAEAAAKTTENPLQ 
                 
               
               
                   
               
               
                 
                   KIDAALAQVDALRSDLGAVQNRFNSAITNLGNTVNNLSEARSRIEDSDYATEVSNMSRAQI 
                 
               
               
                   
               
               
                   LQ AS 
               
             
          
         
       
     
         [0055]    Italics are |YP — 001036450.1| alpha-L-arabinofuranosidase B [ Clostridium thermocellum  ATCC 27405| residues 166-274—this is a dockerin domain that functions fully for binding (e.g., cohesin-antigen fusions) when fused between other domains. 
         [0056]    Bold is the N-terminal part of phase-2 flagellin [ Salmonella enterica ] gb|AAL30512.1|AF425736 — 1 residues 14-161. 
         [0057]    Underlined is the C-terminal part of phase-2 flagellin [ Salmonella enterica ] gb|AAL30512.1|AF425736 — 1 residues 405-484. 
         [0058]    AS sequences in bold-italics are joining sequences from construction of the expression vector. 
         [0059]    When co-transfected with appropriate L chain expression vector into mammalian cells (e.g., CHO—S cells) this vector directs efficient secretion of a typical embodiment of a DC-targeting agent linked to a flagellin-based adjuvant and linked to cohesin-antigen via the dockerin domain. In related embodiments—any desired antigen can also be directly fused in place of the dockerin domain. 
         [0000]    
       
         
               
             
               
             
               
             
           
               
                 C566  E. coli -pET28 vector encoding expression of 
               
               
                 [Cohesin-var1-FluM1-6xHis] 
               
             
          
           
               
                 (SEQ ID NO: 3) 
               
             
          
           
               
                 MDLDAVRIKVDTVNAKPGDTVNIPVRFSGIPSKGIAN A DFVYSYDPNV 
               
               
                   
               
               
                 LEIIEIKPGELIVDPNPTKSFDTAVYPDRKMIVFLFAEDSGTGAYAIT 
               
               
                   
               
               
                 KDGVFATIVAKVKEGAPNGLSVIKFVEVGGFANNDLVEQKTQFFD 
               
               
                   
               
               
                 GGVNVGDTTEPATPTTPVTTPTTTDDLDAAS LLTEVETYVLSIIP   
               
               
                   
               
               
                 
                   SGPLKAEIAQRLEDVFAGKNTDLEVLMEWLKTRPILSPLTKGIL 
                 
               
               
                   
               
               
                 
                   GFVFTLTVPSERGLQRRRFVQNALNGNGDPNNMDKAVKLYR 
                 
               
               
                   
               
               
                 
                   KLKREITFHGAKEIALSYSAGALASCMGLIYNRMGAVTTEVAFG 
                 
               
               
                   
               
               
                 
                   LVCATCEQIADSQHRSHRQMVTTTNPLIRHENRMVLASTTAKA 
                 
               
               
                   
               
               
                 
                   MEQMAGSSEQAAEAMDIASQARQMVQAMRTIGTHPSSSAGL 
                 
               
               
                   
               
               
                   KDDLLENLQAYQKRMGVQMQRFK LEHHHHHH 
               
             
          
         
       
     
         [0060]    Bold is the cohesin domain showing an underlined single C to A change that maintains dockerin binding and 3 C residues (bold-underlined) that permit site-specific maleimide linkage of TLRL adducts. Underlined is the Flu M1 antigen sequence. AS sequences in bold-italics are joining sequences from construction of the expression vector. 
         [0061]    In related forms—any cohesin-antigen with free cys residues can be conveniently decorated with TLR7-L compound and linked with any anti-DC receptor-dockerin-antigen vaccine. 
         [0000]    
       
         
               
             
           
               
                 C1450 encodes mouse Anti-DCIR_9E8_H-LV-hIgG4H-C- 
               
               
                 Flex-v1-v1C2 (SEQ ID NO: 4): 
               
               
                 QVTLKESGPGILQPSQTLSLTCSFSGFSLSTSGMGLSWIRQPSGKGL 
               
               
                   
               
               
                 EWLAHIYWDDDKRYNPSLKSRLTISKDTSSNQVFLKITIVDTADAATYY 
               
               
                   
               
               
                 CARSSHYYGYGYGGYFDVWGAGTTVTVSSAKTKGPSVFPLAPCSRS 
               
               
                   
               
               
                 TSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYS 
               
               
                   
               
               
                 LSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPA 
               
               
                   
               
               
                 PEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWY 
               
               
                   
               
               
                 VDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSN 
               
               
                   
               
               
                 KGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYP 
               
               
                   
               
               
                 SDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNV 
               
               
                   
               
               
                 FSCSVMHEALHNHYTQKSLSLSLGK           QTPTNTISVTPTNNSTPTN   
               
               
                   
               
               
                 
                   NSNPKPNP 
                           
                   C 
                   QTPTNTISVTPTNNSTPTNNSNPKP C   
                   P 
                           
                 
               
             
          
         
       
     
         [0062]    Bold is a flexible linker sequence bearing two C residues (underlined) for site-specific linking TLRL adducts. When co-transfected with appropriate L chain expression vector into mammalian cells (e.g., CHO—S cells) this vector directs efficient secretion of a typical embodiment of a DC-targeting agent linked to a chemical-based adjuvant. In related embodiments—other vectors can be prepared with any desired antigen directly fused to the C-terminal codon. AS sequences in bold-italics are joining sequences from construction of the expression vector. Italics is a flexible linker (supra). 
         [0000]    
       
         
               
             
           
               
                 C1180 directs the expression of a mammalian cell 
               
               
                 expressed 6xHis-Cohesin-Flgn-1-Flgn-2 fusion 
               
               
                 protein (SEQ ID NO: 5): 
               
               
                 LDITSHHHHHHD DLDAVRIKVDTVNAKPGDTVRIPVRFSGIPSKGIAN   
               
               
                   
               
               
                 
                   CDFVYSYDPNVLEIIEIEPGDIIVDPNPDKSFDTAVYPDRKIIVFLFAED 
                 
               
               
                   
               
               
                 
                   SGTGAYAITKDGVFATIVAKVKEGAPNGLSVIKFVEVGGFANNDLVE 
                 
               
               
                   
               
               
                 
                   QKTQFFDGGVNVGDTTEPATPTTPVTTPTTTDDLDA 
                           
                   IERLS 
                 
               
               
                   
               
               
                 
                   SGLRINSAKDDAAGQAIANRFTANIKGLTQASRNANDGISIAQTTEGALN 
                 
               
               
                   
               
               
                 
                   EINNNLQRVRELAVQSANSTNSQSDLDSIQAEITQRLNEIDRVSGQTQF 
                 
               
               
                   
               
               
                   NGVKVLAQDNTLTIQVGANDGETIDIDLKQINSQTLGLDSLNVQ AS QPE   
               
               
                   
               
               
                 
                   LAEAAAKTTENPLQKIDAALAQVDALRSDLGAVQNRFNSAITNLGNTVN 
                 
               
               
                   
               
               
                   NLSEARSRIEDSDYATEVSNMSRAQILQ AS 
               
             
          
         
       
     
         [0063]    Italics is the cohesin domain. Bold is the N-terminal part of phase-2 flagellin [ Salmonella enterica ] gb|AAL30512.1|AF425736 — 1 residues 14-161. Underlined is the C-terminal part of phase-2 flagellin [ Salmonella enterica ] gb|AAL30512.1|AF425736 — 1 residues 405-484. AS sequences in bold-italics are joining sequences from construction of the expression vector. This form permits linking of functional Flgn to any anti-DC receptor-Dockerin-antigen vaccine. 
         [0064]    Some other non-limiting examples of constructs with different DC-specific antibodies or fragments are presented herein below: 
         [0000]    
       
         
               
               
             
           
               
                 Anti_CLEC_6_9B9.2G12_Hv-V-hIgG4H-C (SEQ ID NO: 6): 
                   
               
               
                 ATGGGCAGGCTTACTTCTTCATTCTTGCTACTGATTGTCCCTGCATATGTCCTGTCCCA 
               
               
                   
               
               
                 GGTTACTCTGAAAGAGTCTGGCCCTGGGATATTGCAGCCCTCCCAGACCCTCAGTCTG 
               
               
                   
               
               
                 ACCTGTTCTTTCTCTGGGTTTTCACTGAGCACTTCTGGTATGAGTGTAGGCTGGATTCG 
               
               
                   
               
               
                 TCAGCCTTCAGGGAAGGGTCTGGAGTGGCTGGCTCACATTTGGTGGAATGATGATAAG 
               
               
                   
               
               
                 TACTATAATCCAGTCCTGAAAAGCCGGCTCACAATCTCCAAGGAGACCTCCAACAACC 
               
               
                   
               
               
                 AGGTATTCCTCAAGATCGCCAGTGTGGTCTCTGCAGATACTGCCACATACTACTGTGCT 
               
               
                   
               
               
                 CGATTCTATGGTAACTGTCTTGACTACTGGGGCCAAGGCACCACTCTCACAGTCTCCTC 
               
               
                   
               
               
                 GGCCAAAACAaagggcccATCCGTCTTCCCCCTGGCGCCCTGCTCCAGGAGCACCTCCGAG 
               
               
                   
               
               
                 AGCACAGCCGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGT 
               
               
                   
               
               
                 CGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTC 
               
               
                   
               
               
                 CTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACG 
               
               
                   
               
               
                 AAGACCTACACCTGCAACGTAGATCACAAGCCCAGCAACACCAAGGTGGACAAGAGA 
               
               
                   
               
               
                 GTTGAGTCCAAATATGGTCCCCCATGCCCACCCTGCCCAGCACCTGAGTTCGAAGGGG 
               
               
                   
               
               
                 GACCATCAGTCTTCCTGTTCCCCCCAAAACCCAAGGACACTCTCATGATCTCCCGGACC 
               
               
                   
               
               
                 CCTGAGGTCACGTGCGTGGTGGTGGACGTGAGCCAGGAAGACCCCGAGGTCCAGTTC 
               
               
                   
               
               
                 AACTGGTACGTGGATGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAG 
               
               
                   
               
               
                 CAGTTCAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGC 
               
               
                   
               
               
                 TGAACGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGGCCTCCCGTCCTCCATCGA 
               
               
                   
               
               
                 GAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAGCCACAGGTGTACACCCTGCC 
               
               
                   
               
               
                 CCCATCCCAGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGG 
               
               
                   
               
               
                 CTTCTACCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAA 
               
               
                   
               
               
                 CTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTACAGCAGGC 
               
               
                   
               
               
                 TAACCGTGGACAAGAGCAGGTGGCAGGAGGGGAATGTCTTCTCATGCTCCGTGATGCA 
               
               
                   
               
               
                 TGAGGCTCTGCACAACCACTACACACAGAAGAGCCTCTCCCTGTCTCTGGGTAAAGCT 
               
               
                   
               
               
                 AGCTGATTAATTAA 
               
               
                   
               
               
                 Anti_CLEC_6_9B9.2G12_Hv-V-hIgG4H-C (SEQ ID NO: 7): 
               
               
                 MGRLTSSFLLLIVPAYVLSQVTLKESGPGILQPSQTLSLTCSFSGFSLSTSGMSVGWIRQPSG 
               
               
                   
               
               
                 KGLEWLAHIWWNDDKYYNPVLKSRLTISKETSNNQVFLKIASVVSADTATYYCARFYGN 
               
               
                   
               
               
                 CLDYWGQGTTLTVSSAKTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGA 
               
               
                   
               
               
                 LTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPC 
               
               
                   
               
               
                 PPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNA 
               
               
                   
               
               
                 KTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQ 
               
               
                   
               
               
                 VYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYS 
               
               
                   
               
               
                 RLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGKAS 
               
               
                   
               
               
                 Anti_CLEC_6_9B9.2G12_Kv-V-hIgGK-C (SEQ ID NO: 8): 
               
               
                 ATGATGTCCTCTGCTCAGTTCCTTGGTCTCCTGTTGCTCTGTTTTCAAGGTACCAGATGT 
               
               
                   
               
               
                 GATATCCAGATGACACAGACTACATCCTCCCTGTCTGCCTCTCTGGGAGACAGAGTCA 
               
               
                   
               
               
                 CCATCAGTTGCAGGGCAAGTCAGGACATTAGCAATTATTTAAACTGGTATCAGCAGAA 
               
               
                   
               
               
                 ACCAGATGGAACTGTTAAACTCCTGATCTACTACACATCAATATTACAATTAGGAGTC 
               
               
                   
               
               
                 CCATCAAGATTCAGTGGCAGTGGGTCTGAAACAGATTATTCTCTCACCATTAGCAACC 
               
               
                   
               
               
                 TGGAGCAAGAAGATATTGCCACTTACTTTTGCCAACAGGGTGATTCGCTTCCATTCAC 
               
               
                   
               
               
                 GTTCGGCTCGGGGACAAAGCTCGAGATCAAACGAACTGTGGCTGCACCATCTGTCTTC 
               
               
                   
               
               
                 ATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCT 
               
               
                   
               
               
                 GAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCA 
               
               
                   
               
               
                 ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAG 
               
               
                   
               
               
                 CCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTATGC 
               
               
                   
               
               
                 CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGG 
               
               
                   
               
               
                 AGAGTGTTAG 
               
               
                   
               
               
                 Anti_CLEC_6_9B9.2G12_Kv-V-hIgGK-C (SEQ ID NO: 9): 
               
               
                 MMSSAQFLGLLLLCFQGTRCDIQMTQTTSSLSASLGDRVTISCRASQDISNYLNWYQQKPD 
               
               
                   
               
               
                 GTVKLLIYYTSILQLGVPSRFSGSGSETDYSLTISNLEQEDIATYFCQQGDSLPFTFGSGTKL 
               
               
                   
               
               
                 EIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTE 
               
               
                   
               
               
                 QDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 Anti-ASGPR_49C11_7H-LV-hIgG4H-C (SEQ ID NO: 10): 
               
               
                 ATGAGAGCGCTGATTCTTTTGTGCCTGTTCACAGCCTTTCCTGGTATCCTGTCTGATGT 
               
               
                   
               
               
                 GCAGCTTCAGGAGTCAGGACCTGACCTGGTGAAACCTTCTCAGTCACTTTCACTCACCT 
               
               
                   
               
               
                 GCACTGTCACTGGCTACTCCATCACCAGTGGTTATAGCTGGCACTGGATCCGGCAGTTT 
               
               
                   
               
               
                 CCAGGAAACAAACTGGAATGGATGGGCTACATACTCTTCAGTGGTAGCACTAACTACA 
               
               
                   
               
               
                 ACCCATCTCTGAAAAGTCGAATCTCTATCACTCGAGACACATCCAAGAACCAGTTCTT 
               
               
                   
               
               
                 CCTGCAGTTGAATTCTGTGACTACTGAGGACACAGCCACATATTTCTGTGCAAGATCT 
               
               
                   
               
               
                 AACTATGGTTCCTTTGCTTCCTGGGGCCAAGGGACTCTGGTCACTGTCTCTGCAGCCAA 
               
               
                   
               
               
                 AACAACGGGCCCATCCGTCTTCCCCCTGGCGCCCTGCTCCAGGAGCACCTCCGAGAGC 
               
               
                   
               
               
                 ACAGCCGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGT 
               
               
                   
               
               
                 GGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC 
               
               
                   
               
               
                 AGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACGAAG 
               
               
                   
               
               
                 ACCTACACCTGCAACGTAGATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTT 
               
               
                   
               
               
                 GAGTCCAAATATGGTCCCCCATGCCCACCCTGCCCAGCACCTGAGTTCGAAGGGGGAC 
               
               
                   
               
               
                 CATCAGTCTTCCTGTTCCCCCCAAAACCCAAGGACACTCTCATGATCTCCCGGACCCCT 
               
               
                   
               
               
                 GAGGTCACGTGCGTGGTGGTGGACGTGAGCCAGGAAGACCCCGAGGTCCAGTTCAAC 
               
               
                   
               
               
                 TGGTACGTGGATGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAG 
               
               
                   
               
               
                 TTCAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGA 
               
               
                   
               
               
                 ACGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGGCCTCCCGTCCTCCATCGAGA 
               
               
                   
               
               
                 AAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAGCCACAGGTGTACACCCTGCCCC 
               
               
                   
               
               
                 CATCCCAGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCT 
               
               
                   
               
               
                 TCTACCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACT 
               
               
                   
               
               
                 ACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTACAGCAGGCT 
               
               
                   
               
               
                 AACCGTGGACAAGAGCAGGTGGCAGGAGGGGAATGTCTTCTCATGCTCCGTGATGCAT 
               
               
                   
               
               
                 GAGGCTCTGCACAACCACTACACACAGAAGAGCCTCTCCCTGTCTCTGGGTAAAGCTA 
               
               
                   
               
               
                 GCTGATTAATTAA 
               
               
                   
               
               
                 Anti-ASGPR_49C11_7H-LV-hIgG4H-C (SEQ ID NO: 11): 
               
               
                 MRALILLCLFTAFPGILSDVQLQESGPDLVKPSQSLSLTCTVTGYSITSGYSWHWIRQFPGN 
               
               
                   
               
               
                 KLEWMGYILFSGSTNYNPSLKSRISITRDTSKNQFFLQLNSVTTEDTATYFCARSNYGSFAS 
               
               
                   
               
               
                 WGQGTLVTVSAAKTTGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSG 
               
               
                   
               
               
                 VHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCP 
               
               
                   
               
               
                 APEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTK 
               
               
                   
               
               
                 PREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTL 
               
               
                   
               
               
                 PPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTV 
               
               
                   
               
               
                 DKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGKAS 
               
               
                   
               
               
                 Anti-ASGPR_49C11_7K-LV-hIgGK-C (SEQ ID NO: 12): 
               
               
                 ATGGATTTTCAAGTGCAGATTTTCAGCTTCCTGCTAATCAGTGCCTCAGTCATAATATC 
               
               
                   
               
               
                 CAGAGGACAAATTGTTCTCACCCAGTCTCCAGCAATCATGTCTGCATCTCCAGGGGAG 
               
               
                   
               
               
                 AAGGTCACCATGACCTGCAGTGCCAGCTCAAGTGTAAGTCACATGCACTGGTACCAGC 
               
               
                   
               
               
                 AGAAGTCAGGCACTTCCCCCAAAAGATGGATTTATGACACATCCAGACTGGCTTCTGG 
               
               
                   
               
               
                 AGTCCCTGCTCGCTTCAGTGGCAGTGGGTCTGGGACCTCTTACTCTCTCACAATCAGCA 
               
               
                   
               
               
                 GCATGGAGGCTGAAGATGCTGCCACTTATTACTGCCAGCAGTGGAGTAGTCACCCATG 
               
               
                   
               
               
                 GTCGTTCGGTGGAGGCACCAAACTCGAGATCAAACGAACTGTGGCTGCACCATCTGTC 
               
               
                   
               
               
                 TTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCT 
               
               
                   
               
               
                 GCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTC 
               
               
                   
               
               
                 CAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTAC 
               
               
                   
               
               
                 AGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTAT 
               
               
                   
               
               
                 GCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGG 
               
               
                   
               
               
                 GAGAGTGTTAG 
               
               
                   
               
               
                 Anti-ASGPR_49C11_7K-LV-hIgGK-C (SEQ ID NO: 13): 
               
               
                 MDFQVQIFSFLLISASVIISRGQIVLTQSPAIMSASPGEKVTMTCSASSSVSHMHWYQQKSG 
               
               
                   
               
               
                 TSPKRWIYDTSRLASGVPARFSGSGSGTSYSLTISSMEAEDAATYYCQQWSSHPWSFGGGT 
               
               
                   
               
               
                 KLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESV 
               
               
                   
               
               
                 TEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 Anti-ASGPR_4G2.2_Hv-V-hIgG4H-C (SEQ ID NO: 14): 
               
               
                 ATGGCTTGGGTGTGGACCTTGCTATTCCTGATGGCAGCTGCCCAAAGTGCCCAAGCAC 
               
               
                   
               
               
                 AGATCCAGTTGGTGCAGTCTGGACCTGAGCTGAAGAAGCCTGGAGAGACAGTCAAGA 
               
               
                   
               
               
                 TCTCCTGCAAGGCTTCTGGGTATACCTTCACAAACTATGGAATGAACTGGGTGAAGCA 
               
               
                   
               
               
                 GGTTCCAGGAAAAGGTTTAAGGTGGATGGGCTGGATGGACACCTTCACTGGAGAGCC 
               
               
                   
               
               
                 AACATATGCTGATGACTTCAAGGGACGGTTTGCCTTCTCTTTGGAAACCTCTGCCAGCA 
               
               
                   
               
               
                 CTGCCTATTTGCAGATCAACAGCCTCAAAAATGAGGACACGGCTACTTATTTCTGTGC 
               
               
                   
               
               
                 AAGAGGGGGGATTTTACGACTCAACTACTTTGACTACTGGGGCCAAGGCACCACTCTC 
               
               
                   
               
               
                 ACAGTCTCCTCAGCCAAAACGAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTGCTCCA 
               
               
                   
               
               
                 GGAGCACCTCCGAGAGCACAGCCGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGA 
               
               
                   
               
               
                 ACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCG 
               
               
                   
               
               
                 GCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAG 
               
               
                   
               
               
                 CAGCTTGGGCACGAAGACCTACACCTGCAACGTAGATCACAAGCCCAGCAACACCAA 
               
               
                   
               
               
                 GGTGGACAAGAGAGTTGAGTCCAAATATGGTCCCCCATGCCCACCCTGCCCAGCACCT 
               
               
                   
               
               
                 GAGTTCGAAGGGGGACCATCAGTCTTCCTGTTCCCCCCAAAACCCAAGGACACTCTCA 
               
               
                   
               
               
                 TGATCTCCCGGACCCCTGAGGTCACGTGCGTGGTGGTGGACGTGAGCCAGGAAGACCC 
               
               
                   
               
               
                 CGAGGTCCAGTTCAACTGGTACGTGGATGGCGTGGAGGTGCATAATGCCAAGACAAA 
               
               
                   
               
               
                 GCCGCGGGAGGAGCAGTTCAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTG 
               
               
                   
               
               
                 CACCAGGACTGGCTGAACGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGGCCTC 
               
               
                   
               
               
                 CCGTCCTCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAGCCACAG 
               
               
                   
               
               
                 GTGTACACCCTGCCCCCATCCCAGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCT 
               
               
                   
               
               
                 GCCTGGTCAAAGGCTTCTACCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGC 
               
               
                   
               
               
                 AGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTT 
               
               
                   
               
               
                 CCTCTACAGCAGGCTAACCGTGGACAAGAGCAGGTGGCAGGAGGGGAATGTCTTCTC 
               
               
                   
               
               
                 ATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACACAGAAGAGCCTCTCCCTG 
               
               
                   
               
               
                 TCTCTGGGTAAAGCTAGCTGATTAATTAA 
               
               
                   
               
               
                 Anti-ASGPR_4G2.2_Hv-V-hIgG4H-C (SEQ ID NO: 15): 
               
               
                 MAWVWTLLFLMAAAQSAQAQIQLVQSGPELKKPGETVKISCKASGYTFTNYGMNWVKQ 
               
               
                   
               
               
                 VPGKGLRWMGWMDTFTGEPTYADDFKGRFAFSLETSASTAYLQINSLKNEDTATYFCAR 
               
               
                   
               
               
                 GGILRLNYFDYWGQGTTLTVSSAKTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTV 
               
               
                   
               
               
                 SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVES 
               
               
                   
               
               
                 KYGPPCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDG 
               
               
                   
               
               
                 VEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKG 
               
               
                   
               
               
                 QPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
               
               
                 GSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGKAS 
               
               
                   
               
               
                 Anti-ASGPR_4G2.2_Kv-V-hIgGK-C (SEQ ID NO: 16): 
               
               
                 ATGAAGTTTCCTTCTCAACTTCTGCTCTTACTGCTGTTTGGAATCCCAGGCATGATATG 
               
               
                   
               
               
                 TGACATCCAGATGACACAATCTTCATCCTCCTTTTCTGTATCTCTAGGAGACAGAGTCA 
               
               
                   
               
               
                 CCATTACTTGCAAGGCAAGTGAGGACATATATAATCGGTTAGGCTGGTATCAGCAGAA 
               
               
                   
               
               
                 ACCAGGAAATGCTCCTAGGCTCTTAATATCTGGTGCAACCAGTTTGGAAACTGGGGTT 
               
               
                   
               
               
                 CCTTCAAGATTCAGTGGCAGTGGATCTGGAAAGGATTACGCTCTCAGCATTACCAGTC 
               
               
                   
               
               
                 TTCAGACTGAAGATCTTGCTACTTATTACTGTCAACAGTGTTGGACTTCTCCGTACACG 
               
               
                   
               
               
                 TTCGGAGGGGGGACCAAGCTCGAGATCAAACGAACTGTGGCTGCACCATCTGTCTTCA 
               
               
                   
               
               
                 TCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTG 
               
               
                   
               
               
                 AATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAAT 
               
               
                   
               
               
                 CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCC 
               
               
                   
               
               
                 TCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTATGCCT 
               
               
                   
               
               
                 GCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAG 
               
               
                   
               
               
                 AGTGTTAG 
               
               
                   
               
               
                 Anti-ASGPR_4G2.2_Kv-V-hIgGK-C (SEQ ID NO: 17): 
               
               
                 MKFPSQLLLLLLFGIPGMICDIQMTQSSSSFSVSLGDRVTITCKASEDIYNRLGWYQQKPGN 
               
               
                   
               
               
                 APRLLISGATSLETGVPSRFSGSGSGKDYALSITSLQTEDLATYYCQQCWTSPYTFGGGTKL 
               
               
                   
               
               
                 EIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTE 
               
               
                   
               
               
                 QDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 Anti-ASGPR_5F10H-LV-hIgG4H-C (SEQ ID NO: 18): 
               
               
                 ATGGGATGGAGCTGGATCTTTCTCTTTCTCTTGTCAGGAACTGGAGGTGTCCTCTCTGA 
               
               
                   
               
               
                 GGTCCAGCTGCAACAGTCTGGACCTGAGCTGGTGAAGCCTGGGGCTTCAGTGAAGATG 
               
               
                   
               
               
                 TCCTGCAAGGCTTCTGGATACACCTTCACTGACTACTACATGAAGTGGGTGAAGCAGA 
               
               
                   
               
               
                 GCCATGGAAAGAGCCTTGAGTGGATTGGAGATATTAATCCTAACTATGGTGATACTTT 
               
               
                   
               
               
                 CTACAACCAGAAGTTCGAGGGCAAGGCCACATTGACTGTAGACAAATCCTCCAGGAC 
               
               
                   
               
               
                 AGCCTACATGCAGCTCAACAGCCTGACATCTGAGGACTCTGCAGTCTATTATTGTGGA 
               
               
                   
               
               
                 AGAGGGGACTATGGATACTTCGATGTCTGGGGCGCAGGGACCACGGTCACCGTCTCCT 
               
               
                   
               
               
                 CAGCCAAAACAAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTGCTCCAGGAGCACCTC 
               
               
                   
               
               
                 CGAGAGCACAGCCGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACG 
               
               
                   
               
               
                 GTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTAC 
               
               
                   
               
               
                 AGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGG 
               
               
                   
               
               
                 CACGAAGACCTACACCTGCAACGTAGATCACAAGCCCAGCAACACCAAGGTGGACAA 
               
               
                   
               
               
                 GAGAGTTGAGTCCAAATATGGTCCCCCATGCCCACCCTGCCCAGCACCTGAGTTCGAA 
               
               
                   
               
               
                 GGGGGACCATCAGTCTTCCTGTTCCCCCCAAAACCCAAGGACACTCTCATGATCTCCC 
               
               
                   
               
               
                 GGACCCCTGAGGTCACGTGCGTGGTGGTGGACGTGAGCCAGGAAGACCCCGAGGTCC 
               
               
                   
               
               
                 AGTTCAACTGGTACGTGGATGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGG 
               
               
                   
               
               
                 AGGAGCAGTTCAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGA 
               
               
                   
               
               
                 CTGGCTGAACGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGGCCTCCCGTCCTCC 
               
               
                   
               
               
                 ATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAGCCACAGGTGTACACC 
               
               
                   
               
               
                 CTGCCCCCATCCCAGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCA 
               
               
                   
               
               
                 AAGGCTTCTACCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGA 
               
               
                   
               
               
                 ACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTACAGC 
               
               
                   
               
               
                 AGGCTAACCGTGGACAAGAGCAGGTGGCAGGAGGGGAATGTCTTCTCATGCTCCGTG 
               
               
                   
               
               
                 ATGCATGAGGCTCTGCACAACCACTACACACAGAAGAGCCTCTCCCTGTCTCTGGGTA 
               
               
                   
               
               
                 AAGCTAGCTGA 
               
               
                   
               
               
                 Anti-ASGPR_5F10H-LV-hIgG4H-C (SEQ ID NO: 19): 
               
               
                 MGWSWIFLFLLSGTGGVLSEVQLQQSGPELVKPGASVKMSCKASGYTFTDYYMKWVKQ 
               
               
                   
               
               
                 SHGKSLEWIGDINPNYGDTFYNQKFEGKATLTVDKSSRTAYMQLNSLTSEDSAVYYCGRG 
               
               
                   
               
               
                 DYGYFDVWGAGTTVTVSSAKTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWN 
               
               
                   
               
               
                 SGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYG 
               
               
                   
               
               
                 PPCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEV 
               
               
                   
               
               
                 HNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPR 
               
               
                   
               
               
                 EPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFF 
               
               
                   
               
               
                 LYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLLSLGKAS 
               
               
                   
               
               
                 Anti-ASGPR_5F10K-LV-hIgGK-C (SEQ ID NO: 20): 
               
               
                 ATGGAGACACATTCTCAGGTCTTTGTATACATGTTGCTGTGGTTGTCTGGTGTTGAAGG 
               
               
                   
               
               
                 AGACATTGTGATGACCCAGTCTCACAAATTCATGTCCACATCAGTAGGAGACAGGGTC 
               
               
                   
               
               
                 AGCATCACCTGCAAGGCCAGTCAGGATGTGGGTACTGCTGTAGCCTGGTATCAACAGA 
               
               
                   
               
               
                 AACCAGGGCAATCTCCTAAACTACTGATTTACTGGGCATCCACCCGGCACACTGGAGT 
               
               
                   
               
               
                 CCCTGATCGCTTCACAGGCAGTGGATCTGGGACAGATTTCACTCTCACCATTAACAAT 
               
               
                   
               
               
                 GTGCAGTCTGAAGACTTGGCAGATTATTTCTGTCAGCAATATAGCAGCAATCCGTACA 
               
               
                   
               
               
                 TGTTCGGAGGGGGGACCAAGCTCGAGATCAAACGAACTGTGGCTGCACCATCTGTCTT 
               
               
                   
               
               
                 CATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGC 
               
               
                   
               
               
                 TGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCA 
               
               
                   
               
               
                 ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAG 
               
               
                   
               
               
                 CCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTATGC 
               
               
                   
               
               
                 CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGG 
               
               
                   
               
               
                 AGAGTGTTAG 
               
               
                   
               
               
                 Anti-ASGPR_5F10K-LV-hIgGK-C (SEQ ID NO: 21): 
               
               
                 METHSQVFVYMLLWLSGVEGDIVMTQSHKFMSTSVGDRVSITCKASQDVGTAVAWYQQ 
               
               
                   
               
               
                 KPGQSPKLLIYWASTRHTGVPDRFTGSGSGTDFTLTINNVQSEDLADYFCQQYSSNPYMFG 
               
               
                   
               
               
                 GGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNS 
               
               
                   
               
               
                 QESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 Anti-ASGPR1H11_H-V-hIgG4H-C (SEQ ID NO: 22): 
               
               
                 ATGGGATGGAGCTGGATCTTTCTCTTTCTCCTGTCAGGAACTGCAGGTGTCCTCTCTGA 
               
               
                   
               
               
                 GGTCCAGCTGCAACAGTCTGGACCTGAGTTGGTGAAGCCTGGGGCTTCAGTGAAGATA 
               
               
                   
               
               
                 TCCTGCAAGACTTCTGGATACACATTCACTGAATACACCATGCACTGGGTGAGGCAGA 
               
               
                   
               
               
                 GCCATGGAAAGAGCCTTGAGTGGATTGGAGGTATTAATCCTATCAATGGTGGTCCTAC 
               
               
                   
               
               
                 CTACAACCAGAAGTTCAAGGGCAAGGCCACATTGACTGTTGACAAGTCCTCCAGCACA 
               
               
                   
               
               
                 GCCTACATGGAGCTCCGCAGCCTGACATCTGAGGACTCTGCAGTCTATTACTGTGCAA 
               
               
                   
               
               
                 GATGGGACTATGGTAGTCGAGATGTTATGGACTACTGGGGTCAAGGAACCTCAGTCAC 
               
               
                   
               
               
                 CGTCTCCTCAGCCAAAACGAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTGCTCCAGG 
               
               
                   
               
               
                 AGCACCTCCGAGAGCACAGCCGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAAC 
               
               
                   
               
               
                 CGGTACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTT 
               
               
                   
               
               
                 CCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCT 
               
               
                   
               
               
                 CCAGCAGCTTGGGCACGAAGACCTACACCTGCAACGTAGATCACAAGCCCAGCAACA 
               
               
                   
               
               
                 CCAAGGTGGACAAGAGAGTTGAGTCCAAATATGGTCCCCCATGCCCACCCTGCCCAGC 
               
               
                   
               
               
                 ACCTGAGTTCGAAGGGGGACCATCAGTCTTCCTGTTCCCCCCAAAACCCAAGGACACT 
               
               
                   
               
               
                 CTCATGATCTCCCGGACCCCTGAGGTCACGTGCGTGGTGGTGGACGTGAGCCAGGAAG 
               
               
                   
               
               
                 ACCCCGAGGTCCAGTTCAACTGGTACGTGGATGGCGTGGAGGTGCATAATGCCAAGAC 
               
               
                   
               
               
                 AAAGCCGCGGGAGGAGCAGTTCAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTC 
               
               
                   
               
               
                 CTGCACCAGGACTGGCTGAACGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGGC 
               
               
                   
               
               
                 CTCCCGTCCTCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAGCCAC 
               
               
                   
               
               
                 AGGTGTACACCCTGCCCCCATCCCAGGAGGAGATGACCAAGAACCAGGTCAGCCTGA 
               
               
                   
               
               
                 CCTGCCTGGTCAAAGGCTTCTACCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGG 
               
               
                   
               
               
                 GCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTC 
               
               
                   
               
               
                 TTCCTCTACAGCAGGCTAACCGTGGACAAGAGCAGGTGGCAGGAGGGGAATGTCTTCT 
               
               
                   
               
               
                 CATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACACAGAAGAGCCTCTCCCT 
               
               
                   
               
               
                 GTCTCTGGGTAAAGCTAGCTGA 
               
               
                   
               
               
                 Anti-ASGPR1H11_H-V-hIgG4H-C (SEQ ID NO: 23): 
               
               
                 MGWSWIFLFLLSGTAGVLSEVQLQQSGPELVKPGASVKISCKTSGYTFTEYTMHWVRSHG 
               
               
                   
               
               
                 KSLEWIGGINPINGGPTYNQKFKGKATLTVDKSSSTAYMELRSLTSEDSAVYYCARWDYG 
               
               
                   
               
               
                 SRDVMDYWGQGTSVTVSSAKTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVPVTVS 
               
               
                   
               
               
                 WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVES 
               
               
                   
               
               
                 KYGPPCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDG 
               
               
                   
               
               
                 VEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKG 
               
               
                   
               
               
                 QPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
               
               
                 GSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGKAS 
               
               
                   
               
               
                 Anti-ASGPR1H11K-LV-var2-hIgGK-C (SEQ ID NO: 24): 
               
               
                 ATGGAATCACAGACTCTGGTCTTCATATCCATACTGCTCTGGTTATATGGTGCTGATGG 
               
               
                   
               
               
                 GAACATTGTAATGACTCAATCTCCCAAATCCATGTCCATGTCAGTAGGGGAGAGGGTC 
               
               
                   
               
               
                 ACCTTGAGCTGCAAGGCCAGTGAGAATGTGGGAACTTATGTATCCTGGTATCAACAGA 
               
               
                   
               
               
                 GACCAGAACAGTCTCCAAAACTGCTGATATACGGGGCATCCAACCGGTACACTGGGGT 
               
               
                   
               
               
                 CCCCGATCGCTTCACAGGCAGTGGATCTGCAACAGATTTCACTCTGACCATCAGCAGT 
               
               
                   
               
               
                 GTGCAGGCTGAGGACCTTGCAGATTATCACTGTGGACAGACTTACAGCTATATATTCA 
               
               
                   
               
               
                 CGTTCGGCTCGGGGACAAAGCTCGAGATCAAACGAACTGTGGCTGCACCATCTGTCTT 
               
               
                   
               
               
                 CATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGC 
               
               
                   
               
               
                 TGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCA 
               
               
                   
               
               
                 ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAG 
               
               
                   
               
               
                 CCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTATGC 
               
               
                   
               
               
                 CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGG 
               
               
                   
               
               
                 AGAGTGTTAG 
               
               
                   
               
               
                 Anti-ASGPR1H11K-LV-var2-hIgGK-C (SEQ ID NO: 25): 
               
               
                 METHSQVFVYMLLWLSGVEGNIVMTQSPKSMSMSVGERVTLSCKASENVGTYVSWYQQ 
               
               
                   
               
               
                 RPEQSPKLLIYGASNRYTGVPDRFTGSGSATDFTLTISSVQAEDLADYHCGQTYSYIFTFGS 
               
               
                   
               
               
                 GTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQE 
               
               
                   
               
               
                 SVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 Anti-CD1d_2B5.3G10_H-V-hIgG4H-C (SEQ ID NO: 26): 
               
               
                 ATGGGATGGAGCCGGATCTTTCTCTTCCTCCTGTCAATAACTGCAGGTGTCCATTGCCA 
               
               
                   
               
               
                 GGTCCAGGTGCAGCAGTCGGGACCTGAGTTGGTGAAGCCTGGGGCCTCAGTGAAGATT 
               
               
                   
               
               
                 TCCTGCAAAGCCTCTGGCGACGCATTCAGTAGTTCTTGGATGAACTGGGTGAAGCAGA 
               
               
                   
               
               
                 GGCCTGGACAGGGTCTTGAGTGGATTGGACGGATTTATCTTGGAGATGGAGATATTAA 
               
               
                   
               
               
                 TTACAATGGGAAGTTCAAGGGCAGGGCCACACTGACTGCAGACAAATCCTCCAGCAC 
               
               
                   
               
               
                 AGCCTACATGCAGCTCAGCAGCCTGACCTCTGTGGACTCTGCGGTCTATTTCTGCGCGA 
               
               
                   
               
               
                 GGCAGCTCGGGCTATGGTATGTTATGGACTACTGGGGTCAAGGAACCTCAGTCACCGT 
               
               
                   
               
               
                 CTCCTCAGCCAAAACAAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTGCTCCAGGAGC 
               
               
                   
               
               
                 ACCTCCGAGAGCACAGCCGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGG 
               
               
                   
               
               
                 TGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGT 
               
               
                   
               
               
                 CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGC 
               
               
                   
               
               
                 TTGGGCACGAAGACCTACACCTGCAACGTAGATCACAAGCCCAGCAACACCAAGGTG 
               
               
                   
               
               
                 GACAAGAGAGTTGAGTCCAAATATGGTCCCCCATGCCCACCCTGCCCAGCACCTGAGT 
               
               
                   
               
               
                 TCGAAGGGGGACCATCAGTCTTCCTGTTCCCCCCAAAACCCAAGGACACTCTCATGAT 
               
               
                   
               
               
                 CTCCCGGACCCCTGAGGTCACGTGCGTGGTGGTGGACGTGAGCCAGGAAGACCCCGA 
               
               
                   
               
               
                 GGTCCAGTTCAACTGGTACGTGGATGGCGTGGAGGTGCATAATGCCAAGACAAAGCC 
               
               
                   
               
               
                 GCGGGAGGAGCAGTTCAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCAC 
               
               
                   
               
               
                 CAGGACTGGCTGAACGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGGCCTCCCG 
               
               
                   
               
               
                 TCCTCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAGCCACAGGTG 
               
               
                   
               
               
                 TACACCCTGCCCCCATCCCAGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCC 
               
               
                   
               
               
                 TGGTCAAAGGCTTCTACCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGC 
               
               
                   
               
               
                 CGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCT 
               
               
                   
               
               
                 CTACAGCAGGCTAACCGTGGACAAGAGCAGGTGGCAGGAGGGGAATGTCTTCTCATG 
               
               
                   
               
               
                 CTCCGTGATGCATGAGGCTCTGCACAACCACTACACACAGAAGAGCCTCTCCCTGTCT 
               
               
                   
               
               
                 CTGGGTAAAGCTAGCTGA 
               
               
                   
               
               
                 Anti-CD1d_2B5.3G10_H-V-hIgG4H-C (SEQ ID NO: 27): 
               
               
                 MGWSRIFLFLLSITAGVHCQVQVQQSGPELVKPGASVKISCKASGDAFSSSWMNWVKQRP 
               
               
                   
               
               
                 GQGLEWIGRIYLGDGDINYNGKFKGRATLTADKSSSTAYMQLSSLTSVDSAVYFCARQLG 
               
               
                   
               
               
                 LWYVMDYWGQGTSVTVSSAKTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSW 
               
               
                   
               
               
                 NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKY 
               
               
                   
               
               
                 GPPCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVE 
               
               
                   
               
               
                 VHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQP 
               
               
                   
               
               
                 REPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSF 
               
               
                   
               
               
                 FLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGKAS 
               
               
                   
               
               
                 Anti-CD1d_2B5.3G10_K-V-hIgGK-C (SEQ ID NO: 28): 
               
               
                 ATGAGTGTGCCCACTCAGGTCCTGGGGTTGCTGCTGCTGTGGCTTACAGGTGCCAGAT 
               
               
                   
               
               
                 GTGACATCCAGATGGCTCAGTCTCCAGCCTCCCTATCTGCATCTGTGGGAGAAACTGT 
               
               
                   
               
               
                 CACCATCACATGTCGAGCAAGTGAGAATATTTACAGTTATTTAGCATGGTATCAGCAG 
               
               
                   
               
               
                 AAACAGGGAAAATCTCCTCAGCTCCTGGTCTATAATGCAAAAACCTTAGCAGAAGGTG 
               
               
                   
               
               
                 TGCCATCAAGGTTCAGTGGCAGTGGATCAGGCACACAGTTTTCTCTGAAGATCAACAG 
               
               
                   
               
               
                 CCTGCAGCCTGAAGATTTTGGGAGTTATTACTGTCAACATCATTATGGTTTTCCGTGGA 
               
               
                   
               
               
                 CGTTCGGTGGAGGCACCAAGCTCGAGATCAAACGAACTGTGGCTGCACCATCTGTCTT 
               
               
                   
               
               
                 CATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGC 
               
               
                   
               
               
                 TGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCA 
               
               
                   
               
               
                 ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAG 
               
               
                   
               
               
                 CCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTATGC 
               
               
                   
               
               
                 CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGG 
               
               
                   
               
               
                 AGAGTGTTAG 
               
               
                   
               
               
                 Anti-CD1d_2B5.3G10_K-V-hIgGK-C (SEQ ID NO: 29): 
               
               
                 MSVPTQVLGLLLLWLTGARCDIQMAQSPASLSASVGETVTITCRASENIYSYLAWYQQKQ 
               
               
                   
               
               
                 GKSPQLLVYNAKTLAEGVPSRFSGSGSGTQFSLKINSLQPEDFGSYYCQHHYGFPWTFGGG 
               
               
                   
               
               
                 TKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQES 
               
               
                   
               
               
                 VTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 Anti-CD1d_2H11.2G5_H-V-hIgG4H-C (SEQ ID NO: 30): 
               
               
                 ATGAACTTCGGGCTCAGCTTGATTTTCCTTGTCCTCATTTTAAAAGGTGTCCAGTGTGA 
               
               
                   
               
               
                 GGTGCAGCTGGTGGAGTCTGGGGGAGACTTAGTGAAGCCTGGAGGGTCCCTGAAACT 
               
               
                   
               
               
                 CTCCTGTGCAGCCTCTGGATTCACTTTCAGTAGCTATGGCATGTCTTGGGTTCGCCAGA 
               
               
                   
               
               
                 CTCCAGACAAGAGGCTGGAGTGGGTCGCAGTCATTAGTAGTGGTGGAAGTTCCACCTT 
               
               
                   
               
               
                 CTATCCAGACAGTGTGAAGGGGCGATTCACCATCTCCAGAGACAATGCCAAGAACAC 
               
               
                   
               
               
                 CCTGTACCTGCAAATGAGCAGTCTGAAGTCTGAGGACACAGCCGTGTATTACTGTTCA 
               
               
                   
               
               
                 AGAGGAGGTTACTACTTTGACTACTGGGGCCAAGGCACCACTCTCACAGTCTCCGCAG 
               
               
                   
               
               
                 CCAAAACAAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTGCTCCAGGAGCACCTCCGA 
               
               
                   
               
               
                 GAGCACAGCCGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTG 
               
               
                   
               
               
                 TCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGT 
               
               
                   
               
               
                 CCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCAC 
               
               
                   
               
               
                 GAAGACCTACACCTGCAACGTAGATCACAAGCCCAGCAACACCAAGGTGGACAAGAG 
               
               
                   
               
               
                 AGTTGAGTCCAAATATGGTCCCCCATGCCCACCCTGCCCAGCACCTGAGTTCGAAGGG 
               
               
                   
               
               
                 GGACCATCAGTCTTCCTGTTCCCCCCAAAACCCAAGGACACTCTCATGATCTCCCGGA 
               
               
                   
               
               
                 CCCCTGAGGTCACGTGCGTGGTGGTGGACGTGAGCCAGGAAGACCCCGAGGTCCAGTT 
               
               
                   
               
               
                 CAACTGGTACGTGGATGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGA 
               
               
                   
               
               
                 GCAGTTCAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGG 
               
               
                   
               
               
                 CTGAACGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGGCCTCCCGTCCTCCATCG 
               
               
                   
               
               
                 AGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAGCCACAGGTGTACACCCTGC 
               
               
                   
               
               
                 CCCCATCCCAGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAG 
               
               
                   
               
               
                 GCTTCTACCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACA 
               
               
                   
               
               
                 ACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTACAGCAG 
               
               
                   
               
               
                 GCTAACCGTGGACAAGAGCAGGTGGCAGGAGGGGAATGTCTTCTCATGCTCCGTGATG 
               
               
                   
               
               
                 CATGAGGCTCTGCACAACCACTACACACAGAAGAGCCTCTCCCTGTCTCTGGGTAAAG 
               
               
                   
               
               
                 CTAGCTGA 
               
               
                   
               
               
                 Anti-CD1d_2H11.2G5_H-V-hIgG4H-C (SEQ ID NO: 31): 
               
               
                 MNFGLSLIFLVLILKGVQCEVQLVESGGDLVKPGGSLKLSCAASGFTFSSYGMSWVRQTPD 
               
               
                   
               
               
                 KRLEWVAVISSGGSSTFYPDSVKGRFTISRDNAKNTLYLQMSSLKSEDTAVYYCSRGGYY 
               
               
                   
               
               
                 FDYWGQGTTLTVSAAKTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGAL 
               
               
                   
               
               
                 TSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCP 
               
               
                   
               
               
                 PCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNA 
               
               
                   
               
               
                 KTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQ 
               
               
                   
               
               
                 VYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYS 
               
               
                   
               
               
                 RLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGKAS 
               
               
                   
               
               
                 Anti-CD1d_2H11.2G5_K-V-hIgGK-C (SEQ ID NO: 32): 
               
               
                 ATGAGGTTCCAGGTTCAGGTTCTGGGGCTCCTTCTGCTCTGGATATCAGGTGCCCAGTG 
               
               
                   
               
               
                 TGATGTCCAGATAACCCAGTCTCCATCTTATCTTGCTGCATCTCCTGGAGAAACCATTA 
               
               
                   
               
               
                 CTATTAATTGCAGGGCAAGCAAGACCATTAGCAAATATTTAGCCTGGTATCAAGAGAA 
               
               
                   
               
               
                 ACCTGAGAAAACTGATAAGCTTCTTATCTACTCTGGATCCACTTTGCAATCTGGAATTC 
               
               
                   
               
               
                 CATCAAGGTTCAGTGGCAGTGGATCTGGTACAGATTTCACTCTCACCATCAGTGGCCT 
               
               
                   
               
               
                 GGAGCCTGAAGATTTTGCAATGTATTACTGTCAACAGCATAATGAATACCCGTGGACG 
               
               
                   
               
               
                 TTCGGTGGAGGCACCAAGCTCGAGATCAAACGAACTGTGGCTGCACCATCTGTCTTCA 
               
               
                   
               
               
                 TCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTG 
               
               
                   
               
               
                 AATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAAT 
               
               
                   
               
               
                 CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCC 
               
               
                   
               
               
                 TCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTATGCCT 
               
               
                   
               
               
                 GCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAG 
               
               
                   
               
               
                 AGTGTTAG 
               
               
                   
               
               
                 Anti-CD1d_2H11.2G5_K-V-hIgGK-C (SEQ ID NO: 33): 
               
               
                 MRFQVQVLGLLLLWISGAQCDVQITQSPSYLAASPGETITINCRASKTISKYLAWYQEKPE 
               
               
                   
               
               
                 KTDKLLIYSGSTLQSGIPSRFSGSGSGTDFTLTISGLEPEDFAMYYCQQHNEYPWTFGGGTK 
               
               
                   
               
               
                 LEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVT 
               
               
                   
               
               
                 EQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 Anti-CD40_11B6.1C3_H-LV-hIgG4H-C (SEQ ID NO: 34): 
               
               
                 ATGGGATGGAGCTGGATCTTTCTCTTTCTCCTGTCAGGAACTGCAGGTGTCCTCTCTGA 
               
               
                   
               
               
                 GGTCCAGCTGCAACAGTCTGGACCTGAGCTGGTGAAGCCTGGGGCTTCAGTGAAGATA 
               
               
                   
               
               
                 TCCTGCAAGGCTTCTGGTTACTCATTCACTGGCTACTACATGCACTGGGTGAAGCAAA 
               
               
                   
               
               
                 GCCATGTAAAGAGCCTTGAGTGGATTGGACGTATTAATCCTTACAATGGTGCTACTAG 
               
               
                   
               
               
                 CTACAACCAGAATTTCAAGGACAAGGCCAGCTTGACTGTAGATAAGTCCTCCAGCACA 
               
               
                   
               
               
                 GCCTACATGGAGCTCCACAGCCTGACATCTGAGGACTCTGCAGTCTATTACTGTGCAA 
               
               
                   
               
               
                 GAGAGGACTACGTCTACTGGGGCCAAGGCACCACTCTCACAGTCTCCTCAGCCAAAAC 
               
               
                   
               
               
                 GAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTGCTCCAGGAGCACCTCCGAGAGCACA 
               
               
                   
               
               
                 GCCGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGA 
               
               
                   
               
               
                 ACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGG 
               
               
                   
               
               
                 ACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACGAAGACC 
               
               
                   
               
               
                 TACACCTGCAACGTAGATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAG 
               
               
                   
               
               
                 TCCAAATATGGTCCCCCATGCCCACCCTGCCCAGCACCTGAGTTCGAAGGGGGACCAT 
               
               
                   
               
               
                 CAGTCTTCCTGTTCCCCCCAAAACCCAAGGACACTCTCATGATCTCCCGGACCCCTGAG 
               
               
                   
               
               
                 GTCACGTGCGTGGTGGTGGACGTGAGCCAGGAAGACCCCGAGGTCCAGTTCAACTGGT 
               
               
                   
               
               
                 ACGTGGATGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTTCA 
               
               
                   
               
               
                 ACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAACGG 
               
               
                   
               
               
                 CAAGGAGTACAAGTGCAAGGTCTCCAACAAAGGCCTCCCGTCCTCCATCGAGAAAAC 
               
               
                   
               
               
                 CATCTCCAAAGCCAAAGGGCAGCCCCGAGAGCCACAGGTGTACACCCTGCCCCCATCC 
               
               
                   
               
               
                 CAGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTAC 
               
               
                   
               
               
                 CCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAG 
               
               
                   
               
               
                 ACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTACAGCAGGCTAACCGT 
               
               
                   
               
               
                 GGACAAGAGCAGGTGGCAGGAGGGGAATGTCTTCTCATGCTCCGTGATGCATGAGGC 
               
               
                   
               
               
                 TCTGCACAACCACTACACACAGAAGAGCCTCTCCCTGTCTCTGGGTAAAGCTAGCTGA 
               
               
                   
               
               
                 Anti-CD40_11B6.1C3_H-LV-hIgG4H-C (SEQ ID NO: 35): 
               
               
                 MGWSWIFLFLLSGTAGVLSEVQLQQSGPELVKPGASVKISCKASGYSFTGYYMHWVKQS 
               
               
                   
               
               
                 HVKSLEWIGRINPYNGATSYNQNFKDKASLTVDKSSSTAYMELHSLTSEDSAVYYCARED 
               
               
                   
               
               
                 YVYWGQGTTLTVSSAKTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGAL 
               
               
                   
               
               
                 TSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCP 
               
               
                   
               
               
                 PCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNA 
               
               
                   
               
               
                 KTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQ 
               
               
                   
               
               
                 VYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYS 
               
               
                   
               
               
                 RLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGKAS 
               
               
                   
               
               
                 Anti-CD40_11B6.1C3_K-LV-hIgGK-C (SEQ ID NO: 36): 
               
               
                 ATGAAGTTGCCTGTTAGGCTGTTGGTGCTGATGTTCTGGATTCCTGCTTCCAGCAGTGA 
               
               
                   
               
               
                 TGTTGTGATGACCCAAACTCCACTCTCCCTGCCTGTCAGTCTTGGAGATCAAGCCTCCA 
               
               
                   
               
               
                 TCTCTTGCAGATCTAGTCAGAGCCTTGTACACAGTAATGGAAACACCTATTTACATTGG 
               
               
                   
               
               
                 TACCTGCAGAAGCCAGGCCAGTCTCCAAAGCTCCTGATCTACAAAGTTTCCAACCGAT 
               
               
                   
               
               
                 TTTCTGGGGTCCCAGACAGGTTCAGTGGCAGTGGATCAGGGACAGATTTCGCACTCAA 
               
               
                   
               
               
                 GATCAGTAGAGTGGAGGCTGAGGATCTGGGAGTTTATTTCTGCTCTCAAAGTACACAT 
               
               
                   
               
               
                 GTTCCGTGGACGTTCGGTGGAGGCACCAAGCTCGAGATCAAACGAACTGTGGCTGCAC 
               
               
                   
               
               
                 CATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTT 
               
               
                   
               
               
                 GTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATA 
               
               
                   
               
               
                 ACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACA 
               
               
                   
               
               
                 GCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACA 
               
               
                   
               
               
                 AAGTCTATGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTT 
               
               
                   
               
               
                 CAACAGGGGAGAGTGTTAG 
               
               
                   
               
               
                 Anti-CD40_11B6.1C3_K-LV-hIgGK-C (SEQ ID NO: 37): 
               
               
                 MKLPVRLLVLMFWIPASSSDVVMTQTPLSLPVSLGDQASISCRSSQSLVHSNGNTYLHWY 
               
               
                   
               
               
                 LQKPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTDFALKISRVEAEDLGVYFCSQSTHVPWTF 
               
               
                   
               
               
                 GGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGN 
               
               
                   
               
               
                 SQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 Anti-CD40_12B4.2C10_H-LV-hIgG4H-C (SEQ ID NO: 38): 
               
               
                 ATGGAATGGAGTTGGATATTTCTCTTTCTTCTGTCAGGAACTGCAGGTGTCCACTCTGA 
               
               
                   
               
               
                 GGTCCAGCTGCAGCAGTCTGGACCTGAGCTGGTAAAGCCTGGGGCTTCAGTGAAGATG 
               
               
                   
               
               
                 TCCTGCAAGGCTTCTGGATACACATTCACTGACTATGTTTTGCACTGGGTGAAACAGA 
               
               
                   
               
               
                 AGCCTGGGCAGGGCCTTGAGTGGATTGGATATATTAATCCTTACAATGATGGTACTAA 
               
               
                   
               
               
                 GTACAATGAGAAGTTCAAAGGCAAGGCCACACTGACTTCAGACAAATCCTCCAGCAC 
               
               
                   
               
               
                 AGCCTACATGGAGCTCAGCAGCCTGACCTCTGAGGACTCTGCGGTCTATTACTGTGCA 
               
               
                   
               
               
                 AGGGGCTATCCGGCCTACTCTGGGTATGCTATGGACTACTGGGGTCAAGGAACCTCAG 
               
               
                   
               
               
                 TCACCGTCTCCTCAGCCAAAACGAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTGCTCC 
               
               
                   
               
               
                 AGGAGCACCTCCGAGAGCACAGCCGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG 
               
               
                   
               
               
                 AACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCC 
               
               
                   
               
               
                 GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCA 
               
               
                   
               
               
                 GCAGCTTGGGCACGAAGACCTACACCTGCAACGTAGATCACAAGCCCAGCAACACCA 
               
               
                   
               
               
                 AGGTGGACAAGAGAGTTGAGTCCAAATATGGTCCCCCATGCCCACCCTGCCCAGCACC 
               
               
                   
               
               
                 TGAGTTCGAAGGGGGACCATCAGTCTTCCTGTTCCCCCCAAAACCCAAGGACACTCTC 
               
               
                   
               
               
                 ATGATCTCCCGGACCCCTGAGGTCACGTGCGTGGTGGTGGACGTGAGCCAGGAAGACC 
               
               
                   
               
               
                 CCGAGGTCCAGTTCAACTGGTACGTGGATGGCGTGGAGGTGCATAATGCCAAGACAA 
               
               
                   
               
               
                 AGCCGCGGGAGGAGCAGTTCAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCT 
               
               
                   
               
               
                 GCACCAGGACTGGCTGAACGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGGCCT 
               
               
                   
               
               
                 CCCGTCCTCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAGCCACA 
               
               
                   
               
               
                 GGTGTACACCCTGCCCCCATCCCAGGAGGAGATGACCAAGAACCAGGTCAGCCTGAC 
               
               
                   
               
               
                 CTGCCTGGTCAAAGGCTTCTACCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGG 
               
               
                   
               
               
                 CAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCT 
               
               
                   
               
               
                 TCCTCTACAGCAGGCTAACCGTGGACAAGAGCAGGTGGCAGGAGGGGAATGTCTTCTC 
               
               
                   
               
               
                 ATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACACAGAAGAGCCTCTCCCTG 
               
               
                   
               
               
                 TCTCTGGGTAAAGCTAGCTGA 
               
               
                   
               
               
                 Anti-CD40_12B4.2C10_H-LV-hIgG4H-C (SEQ ID NO: 39): 
               
               
                 MEWSWIFLFLLSGTAGVHSEVQLQQSGPELVKPGASVKMSCKASGYTFTDYVLHWVKQK 
               
               
                   
               
               
                 PGQGLEWIGYINPYNDGTKYNEKFKGKATLTSDKSSSTAYMELSSLTSEDSAVYYCARGY 
               
               
                   
               
               
                 PAYSGYAMDYWGQGTSVTVSSAKTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTV 
               
               
                   
               
               
                 SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVES 
               
               
                   
               
               
                 KYGPPCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDG 
               
               
                   
               
               
                 VEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKG 
               
               
                   
               
               
                 QPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
               
               
                 GSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGKAS 
               
               
                   
               
               
                 Anti-CD40_12B4.2C10_K-LV-v2-hIgGK-C (SEQ ID NO: 40): 
               
               
                 ATGATGTCCTCTGCTCAGTTCCTTGGTCTCCTGTTGCTCTGTTTTCAAGGTACCAGATGT 
               
               
                   
               
               
                 GATATCCAGATGACACAGACTACATCCTCCCTGTCTGCCTCTCTGGGAGACAGAGTCA 
               
               
                   
               
               
                 CCATCAGTTGCAGGGCAAGTCAGGACATTAGCAATTATTTAAACTGGTATCAGCAGAA 
               
               
                   
               
               
                 ACCAGATGGAACTGTTAAACTCCTGATCTACTACACATCAAGATTACACTCAGGAGTC 
               
               
                   
               
               
                 CCATCAAGGTTCAGTGGCAGTGGGTCTGGAACAGATTATTCTCTCACCATTAGCAACC 
               
               
                   
               
               
                 TGGAGCAAGAAGATATTGCCACTTACTTTTGCCATCATGGTAATACGCTTCCGTGGAC 
               
               
                   
               
               
                 GTTCGGTGGAGGCACCAAGCTCGAGATCAAACGAACTGTGGCTGCACCATCTGTCTTC 
               
               
                   
               
               
                 ATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCT 
               
               
                   
               
               
                 GAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCA 
               
               
                   
               
               
                 ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAG 
               
               
                   
               
               
                 CCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTATGC 
               
               
                   
               
               
                 CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGG 
               
               
                   
               
               
                 AGAGTGTTAG 
               
               
                   
               
               
                 Anti-CD40_12B4.2C10_K-LV-v2-hIgGK-C (SEQ ID NO: 41): 
               
               
                 MMSSAQFLGLLLLCFQGTRCDIQMTQTTSSLSASLGDRVTISCRASQDISNYLNWYQQKPD 
               
               
                   
               
               
                 GTVKLLIYYTSRLHSGVPSRFSGSGSGTDYSLTISNLEQEDIATYFCHHGNTLPWTFGGGTK 
               
               
                   
               
               
                 LEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVT 
               
               
                   
               
               
                 EQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 Anti-CD40_12E12.3F3_H-V-hIgG4H-C (SEQ ID NO: 42): 
               
               
                 ATGAACTTGGGGCTCAGCTTGATTTTCCTTGTCCTTGTTTTAAAAGGTGTCCAGTGTGA 
               
               
                   
               
               
                 AGTGAAGCTGGTGGAGTCTGGGGGAGGCTTAGTGCAGCCTGGAGGGTCCCTGAAACT 
               
               
                   
               
               
                 CTCCTGTGCAACCTCTGGATTCACTTTCAGTGACTATTACATGTATTGGGTTCGCCAGA 
               
               
                   
               
               
                 CTCCAGAGAAGAGGCTGGAGTGGGTCGCATACATTAATTCTGGTGGTGGTAGCACCTA 
               
               
                   
               
               
                 TTATCCAGACACTGTAAAGGGCCGATTCACCATCTCCAGAGACAATGCCAAGAACACC 
               
               
                   
               
               
                 CTGTACCTGCAAATGAGCCGGCTGAAGTCTGAGGACACAGCCATGTATTACTGTGCAA 
               
               
                   
               
               
                 GACGGGGGTTACCGTTCCATGCTATGGACTATTGGGGTCAAGGAACCTCAGTCACCGT 
               
               
                   
               
               
                 CTCCTCAGCCAAAACGAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTGCTCCAGGAGC 
               
               
                   
               
               
                 ACCTCCGAGAGCACAGCCGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGG 
               
               
                   
               
               
                 TGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGT 
               
               
                   
               
               
                 CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGC 
               
               
                   
               
               
                 TTGGGCACGAAGACCTACACCTGCAACGTAGATCACAAGCCCAGCAACACCAAGGTG 
               
               
                   
               
               
                 GACAAGAGAGTTGAGTCCAAATATGGTCCCCCATGCCCACCCTGCCCAGCACCTGAGT 
               
               
                   
               
               
                 TCGAAGGGGGACCATCAGTCTTCCTGTTCCCCCCAAAACCCAAGGACACTCTCATGAT 
               
               
                   
               
               
                 CTCCCGGACCCCTGAGGTCACGTGCGTGGTGGTGGACGTGAGCCAGGAAGACCCCGA 
               
               
                   
               
               
                 GGTCCAGTTCAACTGGTACGTGGATGGCGTGGAGGTGCATAATGCCAAGACAAAGCC 
               
               
                   
               
               
                 GCGGGAGGAGCAGTTCAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCAC 
               
               
                   
               
               
                 CAGGACTGGCTGAACGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGGCCTCCCG 
               
               
                   
               
               
                 TCCTCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAGCCACAGGTG 
               
               
                   
               
               
                 TACACCCTGCCCCCATCCCAGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCC 
               
               
                   
               
               
                 TGGTCAAAGGCTTCTACCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGC 
               
               
                   
               
               
                 CGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCT 
               
               
                   
               
               
                 CTACAGCAGGCTAACCGTGGACAAGAGCAGGTGGCAGGAGGGGAATGTCTTCTCATG 
               
               
                   
               
               
                 CTCCGTGATGCATGAGGCTCTGCACAACCACTACACACAGAAGAGCCTCTCCCTGTCT 
               
               
                   
               
               
                 CTGGGTAAAGCTAGCTGA 
               
               
                   
               
               
                 Anti-CD40_12E12.3F3_H-V-hIgG4H-C (SEQ ID NO: 43): 
               
               
                 MNLGLSLIFLVLVLKGVQCEVKLVESGGGLVQPGGSLKLSCATSGFTFSDYYMYWVRQTP 
               
               
                   
               
               
                 EKRLEWVAYINSGGGSTYYPDTVKGRFTISRDNAKNTLYLQMSRLKSEDTAMYYCARRG 
               
               
                   
               
               
                 LPFHAMDYWGQGTSVTVSSAKTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSW 
               
               
                   
               
               
                 NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKY 
               
               
                   
               
               
                 GPPCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVE 
               
               
                   
               
               
                 VHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQP 
               
               
                   
               
               
                 REPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSF 
               
               
                   
               
               
                 FLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGKAS 
               
               
                   
               
               
                 Anti-CD40_12E12.3F3_K-LV-hIgGK-C (SEQ ID NO: 44): 
               
               
                 ATGATGTCCTCTGCTCAGTTCCTTGGTCTCCTGTTGCTCTGTTTTCAAGGTACCAGATGT 
               
               
                   
               
               
                 GATATCCAGATGACACAGACTACATCCTCCCTGTCTGCCTCTCTAGGAGACAGAGTCA 
               
               
                   
               
               
                 CCATCAGTTGCAGTGCAAGTCAGGGCATTAGCAATTATTTAAACTGGTATCAGCAGAA 
               
               
                   
               
               
                 ACCAGATGGAACTGTTAAACTCCTGATCTATTACACATCAATTTTACACTCAGGAGTCC 
               
               
                   
               
               
                 CATCAAGGTTCAGTGGCAGTGGGTCTGGGACAGATTATTCTCTCACCATCGGCAACCT 
               
               
                   
               
               
                 GGAACCTGAAGATATTGCCACTTACTATTGTCAGCAGTTTAATAAGCTTCCTCCGACGT 
               
               
                   
               
               
                 TCGGTGGAGGCACCAAACTCGAGATCAAACGAACTGTGGCTGCACCATCTGTCTTCAT 
               
               
                   
               
               
                 CTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGA 
               
               
                   
               
               
                 ATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATC 
               
               
                   
               
               
                 GGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCT 
               
               
                   
               
               
                 CAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTATGCCTG 
               
               
                   
               
               
                 CGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGA 
               
               
                   
               
               
                 GTGTTAG 
               
               
                   
               
               
                 Anti-CD40_12E12.3F3_K-LV-hIgGK-C (SEQ ID NO: 45): 
               
               
                 MMSSAQFLGLLLLCFQGTRCDIQMTQTTSSLSASLGDRVTISCSASQGISNYLNWYQQKPD 
               
               
                   
               
               
                 GTVKLLIYYTSILHSGVPSRFSGSGSGTDYSLTIGNLEPEDIATYYCQQFNKLPPTFGGGTKL 
               
               
                   
               
               
                 EIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTE 
               
               
                   
               
               
                 QDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 Anti-DCIR_24A5.4A5_H-V-hIgG4H-C (SEQ ID NO: 46): 
               
               
                 ATGGATTGGCTGTGGAACTTGCTATTCCTGATGGCAGCTGCCCAAAGTGCCCAAGCAC 
               
               
                   
               
               
                 AGATCCAGTTGGTGCAGTCTGGACCTGAGCTGAAGAAGCCTGGAGAGACAGTCAAGA 
               
               
                   
               
               
                 TCTCCTGCAAGGCTTCTGGGTATTCCTTCACAAACTATGGAATGAACTGGGTGAAACA 
               
               
                   
               
               
                 GGCTCCAGGAAAGGGTTTAAAGTGGATGGGCTGGATAAACACCTACACTGGAGAGTC 
               
               
                   
               
               
                 AACATATGCTGATGACTTCAAGGGACGGTTTGCCTTCTCTTTGGAAACCTCTGCCAGCA 
               
               
                   
               
               
                 CTGCCTATTTGCAGATCAGTAACCTCAAAAATGAGGACATGGCTACATATTTCTGTGCT 
               
               
                   
               
               
                 AGAGGGGACTTTAGGTACTACTATTTTGACTACTGGGGCCAAGGCACCACTCTCACAG 
               
               
                   
               
               
                 GCTCCTCAGCCAAAACGAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTGCTCCAGGAG 
               
               
                   
               
               
                 CACCTCCGAGAGCACAGCCGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCG 
               
               
                   
               
               
                 GTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTG 
               
               
                   
               
               
                 TCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAG 
               
               
                   
               
               
                 CTTGGGCACGAAGACCTACACCTGCAACGTAGATCACAAGCCCAGCAACACCAAGGT 
               
               
                   
               
               
                 GGACAAGAGAGTTGAGTCCAAATATGGTCCCCCATGCCCACCCTGCCCAGCACCTGAG 
               
               
                   
               
               
                 TTCGAAGGGGGACCATCAGTCTTCCTGTTCCCCCCAAAACCCAAGGACACTCTCATGA 
               
               
                   
               
               
                 TCTCCCGGACCCCTGAGGTCACGTGCGTGGTGGTGGACGTGAGCCAGGAAGACCCCGA 
               
               
                   
               
               
                 GGTCCAGTTCAACTGGTACGTGGATGGCGTGGAGGTGCATAATGCCAAGACAAAGCC 
               
               
                   
               
               
                 GCGGGAGGAGCAGTTCAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCAC 
               
               
                   
               
               
                 CAGGACTGGCTGAACGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGGCCTCCCG 
               
               
                   
               
               
                 TCCTCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAGCCACAGGTG 
               
               
                   
               
               
                 TACACCCTGCCCCCATCCCAGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCC 
               
               
                   
               
               
                 TGGTCAAAGGCTTCTACCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGC 
               
               
                   
               
               
                 CGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCT 
               
               
                   
               
               
                 CTACAGCAGGCTAACCGTGGACAAGAGCAGGTGGCAGGAGGGGAATGTCTTCTCATG 
               
               
                   
               
               
                 CTCCGTGATGCATGAGGCTCTGCACAACCACTACACACAGAAGAGCCTCTCCCTGTCT 
               
               
                   
               
               
                 CTGGGTAAAGCTAGCTGAT 
               
               
                   
               
               
                 Anti-DCIR_24A5.4A5_H-V-hIgG4H-C (SEQ ID NO: 47): 
               
               
                 MDWLWNLLFLMAAAQSAQAQIQLVQSGPELKKPGETVKISCKASGYSFTNYGMNWVKQ 
               
               
                   
               
               
                 APGKGLKWMGWINTYTGESTYADDFKGRFAFSLETSASTAYLQISNLKNEDMATYFCAR 
               
               
                   
               
               
                 GDFRYYYFDYWGQGTTLTGSSAKTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVS 
               
               
                   
               
               
                 WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVES 
               
               
                   
               
               
                 KYGPPCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDG 
               
               
                   
               
               
                 VEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKG 
               
               
                   
               
               
                 QPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
               
               
                 GSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGKAS 
               
               
                   
               
               
                 Anti-DCIR_24A5.4A5_K-V-hIgGK-C (SEQ ID NO: 48): 
               
               
                 ATGAGTGTGCTCACTCAGGTCCTGGCGTTGCTGCTGCTGTGGCTTACAGGTGCCAGAT 
               
               
                   
               
               
                 GTGACATCCAGATGACTCAGTCTCCAGCCTCCCTATCTGCATCTGTGGGAGAAACTGT 
               
               
                   
               
               
                 CACCATCACGTGTCGAGCAAGTGGGAATATTCACAATTATTTAGCATGGTATCAGCAG 
               
               
                   
               
               
                 AAACAGGGAAAATCTCCTCAGCTCCTGGTCTATAATGCAAAAACCTTGGCAGATGGTG 
               
               
                   
               
               
                 TGCCATCAAGGTTCAGTGGCAGTGGATCAGGAACACAATATTCTCTCAAGATCAACAC 
               
               
                   
               
               
                 CCTGCAGCCTGAAGATTTTGGGAGTTATTACTGTCAACATTTTTGGGATTCTTGGACGT 
               
               
                   
               
               
                 TCGGTGGAGGCACCAAGCTCGAGATCAAACGAACTGTGGCTGCACCATCTGTCTTCAT 
               
               
                   
               
               
                 CTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGA 
               
               
                   
               
               
                 ATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAATC 
               
               
                   
               
               
                 GGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCCT 
               
               
                   
               
               
                 CAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTATGCCTG 
               
               
                   
               
               
                 CGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGA 
               
               
                   
               
               
                 GTGTTAG 
               
               
                   
               
               
                 Anti-DCIR_24A5.4A5_K-V-hIgGK-C (SEQ ID NO: 49): 
               
               
                 MSVLTQVLALLLLWLTGARCDIQMTQSPASLSASVGETVTITCRASGNIHNYLAWYQQKQ 
               
               
                   
               
               
                 GKSPQLLVYNAKTLADGVPSRFSGSGSGTQYSLKINTLQPEDFGSYYCQHFWDSWTFGGG 
               
               
                   
               
               
                 TKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQES 
               
               
                   
               
               
                 VTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 Anti-DCIR_24E7.3H9_H-V-hIgG4H-C (SEQ ID NO: 50): 
               
               
                 ATGGAATGGACCTGGGTCTTTCTCTTCCTCCTGTCAGTAACTGCAGGTGTCCACTCCCA 
               
               
                   
               
               
                 GGTTCAGCTGCAGCAGTCTGGAGCTGAGCTGATGAAGCCTGGGGCCTCAGTGAAGATA 
               
               
                   
               
               
                 TCCTGCAAGGCTACTGGCTACACATTCAGTAGCTACTGGATAGAGTGGGTAAAGCAGA 
               
               
                   
               
               
                 GGCCTGGACATGGCCTTGAGTGGATTGGAGAGATTTTACCTGGAAGTGGTAGGACTAA 
               
               
                   
               
               
                 CGACAATGAGAAGTTCAAGGGCAAGGCCACATTCACTGCAGATACATCCTCCAAGAA 
               
               
                   
               
               
                 AGCCTACATGCAACTCAGCAGCCTGACATCTGAGGACTCTGCCGTCTATTATTGTGCA 
               
               
                   
               
               
                 AGAAGGGGTGGTTACTCCTTTGCTTACTGGGGCCAAGGGACTCTGGTCACTGTCTCTG 
               
               
                   
               
               
                 CAGCCAAAACAAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTGCTCCAGGAGCACCTC 
               
               
                   
               
               
                 CGAGAGCACAGCCGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACG 
               
               
                   
               
               
                 GTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTAC 
               
               
                   
               
               
                 AGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGG 
               
               
                   
               
               
                 CACGAAGACCTACACCTGCAACGTAGATCACAAGCCCAGCAACACCAAGGTGGACAA 
               
               
                   
               
               
                 GAGAGTTGAGTCCAAATATGGTCCCCCATGCCCACCCTGCCCAGCACCTGAGTTCGAA 
               
               
                   
               
               
                 GGGGGACCATCAGTCTTCCTGTTCCCCCCAAAACCCAAGGACACTCTCATGATCTCCC 
               
               
                   
               
               
                 GGACCCCTGAGGTCACGTGCGTGGTGGTGGACGTGAGCCAGGAAGACCCCGAGGTCC 
               
               
                   
               
               
                 AGTTCAACTGGTACGTGGATGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGG 
               
               
                   
               
               
                 AGGAGCAGTTCAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGA 
               
               
                   
               
               
                 CTGGCTGAACGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGGCCTCCCGTCCTCC 
               
               
                   
               
               
                 ATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAGCCACAGGTGTACACC 
               
               
                   
               
               
                 CTGCCCCCATCCCAGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCA 
               
               
                   
               
               
                 AAGGCTTCTACCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGA 
               
               
                   
               
               
                 ACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTACAGC 
               
               
                   
               
               
                 AGGCTAACCGTGGACAAGAGCAGGTGGCAGGAGGGGAATGTCTTCTCATGCTCCGTG 
               
               
                   
               
               
                 ATGCATGAGGCTCTGCACAACCACTACACACAGAAGAGCCTCTCCCTGTCTCTGGGTA 
               
               
                   
               
               
                 AAGCTAGCTGA 
               
               
                   
               
               
                 Anti-DCIR_24E7.3H9_H-V-hIgG4H-C (SEQ ID NO: 51): 
               
               
                 MEWTWVFLFLLSVTAGVHSQVQLQQSGAELMKPGASVKISCKATGYTFSSYWIEWVKQR 
               
               
                   
               
               
                 PGHGLEWIGEILPGSGRTNDNEKFKGKATFTADTSSKKAYMQLSSLTSEDSAVYYCARRG 
               
               
                   
               
               
                 GYSFAYWGQGTLVTVSAAKTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNS 
               
               
                   
               
               
                 GALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGP 
               
               
                   
               
               
                 PCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVH 
               
               
                   
               
               
                 NAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPRE 
               
               
                   
               
               
                 PQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL 
               
               
                   
               
               
                 YSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGKAS 
               
               
                   
               
               
                 Anti-DCIR_24E7.3H9_K-V-hIgGK-C (SEQ ID NO: 52): 
               
               
                 ATGACCATGTTCTCACTAGCTCTTCTCCTCAGTCTTCTTCTCCTCTGTGTCTCTGATTCT 
               
               
                   
               
               
                 AGGGCAGAAACAACTGTGACCCAGTCTATGACCATGTTCTCACTAGCTCTTCTCCTCA 
               
               
                   
               
               
                 GTCTTCTTCTCCTCTGTGTCTCTGATTCTAGGGCAGAAACAACTGTGACCCAGTCTCCA 
               
               
                   
               
               
                 GCATCCCTGTCCATGGCTATAGGGGAAAAAGTCACCATCAGATGCGTAACCAGCACTG 
               
               
                   
               
               
                 ATATTGATGATGATGTGAACTGGTACCAGCAGAAGCCAGGGGAACCTCCTAAACTCCT 
               
               
                   
               
               
                 TATTTCAGAAGGCAATACTCTTCGTCCTGGAGTCCCATCCCGATTCTCCAGCAGTGGCT 
               
               
                   
               
               
                 ATGGTACAGATTTTGTTTTTACAATTGAGAACATGCTCTCAGAAGATGTTGCAGATTAC 
               
               
                   
               
               
                 TACTGTTTGCAAAGTGGTAACTTGCCGTACACGTTCGGAGGGGGGACCAAGCTCGAGA 
               
               
                   
               
               
                 TCAAACGAACTGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTG 
               
               
                   
               
               
                 AAATCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCA 
               
               
                   
               
               
                 AAGTACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCA 
               
               
                   
               
               
                 CAGAGCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCA 
               
               
                   
               
               
                 AAGCAGACTACGAGAAACACAAAGTCTATGCCTGCGAAGTCACCCATCAGGGCCTGA 
               
               
                   
               
               
                 GCTCGCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTTAGCCAGCATCCCTGTCCAT 
               
               
                   
               
               
                 GGCTATAGGGGAAAAAGTCACCATCAGATGCGTAACCAGCACTGATATTGATGATGAT 
               
               
                   
               
               
                 GTGAACTGGTACCAGCAGAAGCCAGGGGAACCTCCTAAACTCCTTATTTCAGAAGGCA 
               
               
                   
               
               
                 ATACTCTTCGTCCTGGAGTCCCATCCCGATTCTCCAGCAGTGGCTATGGTACAGATTTT 
               
               
                   
               
               
                 GTTTTTACAATTGAGAACATGCTCTCAGAAGATGTTGCAGATTACTACTGTTTGCAAAG 
               
               
                   
               
               
                 TGGTAACTTGCCGTACACGTTCGGAGGGGGGACCAAGCTCGAGATCAAACGAACTGT 
               
               
                   
               
               
                 GGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTG 
               
               
                   
               
               
                 CCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAA 
               
               
                   
               
               
                 GGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAG 
               
               
                   
               
               
                 CAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGA 
               
               
                   
               
               
                 GAAACACAAAGTCTATGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACA 
               
               
                   
               
               
                 AAGAGCTTCAACAGGGGAGAGTGTTAG 
               
               
                   
               
               
                 Anti-DCIR_24E7.3H9K-V-hIgGK-C (SEQ ID NO: 53): 
               
               
                 MTMFSLALLLSLLLLCVSDSRAETTVTQSPASLSMAIGEKVTIRCVTSTDIDDDVNWYQQK 
               
               
                   
               
               
                 PGEPPKLLISEGNTLRPGVPSRFSSSGYGTDFVFTIENMLSEDVADYYCLQSGNLPYTFGGG 
               
               
                   
               
               
                 TKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQES 
               
               
                   
               
               
                 VTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 Anti-DCIR_29E9.2E2_H-VhIgG4H-C (SEQ ID NO: 54): 
               
               
                 ATGGCTTGGGTGTGGACCTTGCTATTCCTGATGGCAGCTGCCCAAAGTGCCCAAGCAC 
               
               
                   
               
               
                 AGATCCAGTTGGTGCAGTCTGGACCTGAGCTGAAGAAGCCTGGAGAGACAGTCAAGA 
               
               
                   
               
               
                 TCTCCTGCAAGGCTTCTGGGTATACCTTCACAAACTATGGAATGAACTGGGTGAAGCA 
               
               
                   
               
               
                 GGCTCCAGGAAAGGGTTTAAAGTGGGTGGGCTGGATAAACACCTTCACTGGAGAGCC 
               
               
                   
               
               
                 AACATATGTTGATGACTTCAAGGGACGGTTTGCCTTCTCTTTGGAAACCTCTGCCAGCA 
               
               
                   
               
               
                 CTGCCTATTTGCAGATCAACAACCTCAAAAATGAGGACACGGCTACATATTTCTGTGC 
               
               
                   
               
               
                 AAGAGGGAATTTTAGGTACTACTACTTTGACTACTGGGGCCAAGGCACCACTCTCACA 
               
               
                   
               
               
                 GTCTCCTCAGCCAAAACAAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTGCTCCAGGA 
               
               
                   
               
               
                 GCACCTCCGAGAGCACAGCCGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACC 
               
               
                   
               
               
                 GGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCT 
               
               
                   
               
               
                 GTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCA 
               
               
                   
               
               
                 GCTTGGGCACGAAGACCTACACCTGCAACGTAGATCACAAGCCCAGCAACACCAAGG 
               
               
                   
               
               
                 TGGACAAGAGAGTTGAGTCCAAATATGGTCCCCCATGCCCACCCTGCCCAGCACCTGA 
               
               
                   
               
               
                 GTTCGAAGGGGGACCATCAGTCTTCCTGTTCCCCCCAAAACCCAAGGACACTCTCATG 
               
               
                   
               
               
                 ATCTCCCGGACCCCTGAGGTCACGTGCGTGGTGGTGGACGTGAGCCAGGAAGACCCCG 
               
               
                   
               
               
                 AGGTCCAGTTCAACTGGTACGTGGATGGCGTGGAGGTGCATAATGCCAAGACAAAGC 
               
               
                   
               
               
                 CGCGGGAGGAGCAGTTCAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCA 
               
               
                   
               
               
                 CCAGGACTGGCTGAACGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGGCCTCCC 
               
               
                   
               
               
                 GTCCTCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAGCCACAGGT 
               
               
                   
               
               
                 GTACACCCTGCCCCCATCCCAGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGC 
               
               
                   
               
               
                 CTGGTCAAAGGCTTCTACCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAG 
               
               
                   
               
               
                 CCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCC 
               
               
                   
               
               
                 TCTACAGCAGGCTAACCGTGGACAAGAGCAGGTGGCAGGAGGGGAATGTCTTCTCAT 
               
               
                   
               
               
                 GCTCCGTGATGCATGAGGCTCTGCACAACCACTACACACAGAAGAGCCTCTCCCTGTC 
               
               
                   
               
               
                 TCTGGGTAAAGCTAGCTGA 
               
               
                   
               
               
                 Anti-DCIR_29E9.2E2_H-VhIgG4H-C (SEQ ID NO: 55): 
               
               
                 MAWVWTLLFLMAAAQSAQAQIQLVQSGPELKKPGETVKISCKASGYTFTNYGMNWVKQ 
               
               
                   
               
               
                 APGKGLKWVGWINTFTGEPTYVDDFKGRFAFSLETSASTAYLQINNLKNEDTATYFCARG 
               
               
                   
               
               
                 NFRYYYFDYWGQGTTLTVSSAKTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVS 
               
               
                   
               
               
                 WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVES 
               
               
                   
               
               
                 KYGPPCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDG 
               
               
                   
               
               
                 VEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKG 
               
               
                   
               
               
                 QPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
               
               
                 GSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGKAS 
               
               
                   
               
               
                 Anti-DCIR_29E9.2E2_K-V-hIgGK-C (SEQ ID NO: 56): 
               
               
                 ATGAGTGTGCTCACTCAGGTCCTGGCGTTGCTGCTGCTGTGGCTTACAGGTGCCAGAT 
               
               
                   
               
               
                 GTGACATCCAGATGACTCAGTCCCCAGCCTCCCTATCTGCATCTGTGGGAGAAACTGT 
               
               
                   
               
               
                 CACCATCACATGTCGAACAAGTGGGAATATTCGCAATTATTTAGCATGGTATCAGCAG 
               
               
                   
               
               
                 AAACAGGGAAAATCTCCTCAACTCCTGGTCTATAATGCAAAAACCTTAGCAGATGGTG 
               
               
                   
               
               
                 TGCCATCAAGGTTCGGTGGCAGTGGATCAGGAACACAATATTCTCTCAAGATCAACAG 
               
               
                   
               
               
                 CCTGCAGCCTGAAGATTTTGGGAATTATTACTGTCAACATTTTTGGAGTAGTCCGTACA 
               
               
                   
               
               
                 CGTTCGGAGGGGGGACCAAGCTCGAGATCAAACGAACTGTGGCTGCACCATCTGTCTT 
               
               
                   
               
               
                 CATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGC 
               
               
                   
               
               
                 TGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCA 
               
               
                   
               
               
                 ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAG 
               
               
                   
               
               
                 CCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTATGC 
               
               
                   
               
               
                 CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGG 
               
               
                   
               
               
                 AGAGTGTTAG 
               
               
                   
               
               
                 Anti-DCIR_29E9.2E2_K-V-hIgGK-C (SEQ ID NO: 57): 
               
               
                 MSVLTQVLALLLLWLTGARCDIQMTQSPASLSASVGETVTITCRTSGNIRNYLAWYQQKQ 
               
               
                   
               
               
                 GKSPQLLVYNAKTLADGVPSRFGGSGSGTQYSLKINSLQPEDFGNYYCQHFWSSPYTFGG 
               
               
                   
               
               
                 GTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQE 
               
               
                   
               
               
                 SVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 Anti-DCIR_29G10.3D9_H-V-hIgG4H-C (SEQ ID NO: 58): 
               
               
                 ATGATGGGATGGAGCTATATCATCCTCTTTTTGGTAGCAACAGCTACAGATGTCCACTC 
               
               
                   
               
               
                 CCAGGTCCAACTGCAGCAGCCTGGGGCTGAACTGGTGAAGCCTGGGGCTTCAGTGAA 
               
               
                   
               
               
                 GCTGTCCTGCAAGGCTTCTGGCTACACCTTCACCAGCTACTGGATGCACTGGGTGAAG 
               
               
                   
               
               
                 CAGAGGCCTGGAGAAGGCCTTGAGTGGATTGGAGAGATTAATCCTAGCTACGGTCGTA 
               
               
                   
               
               
                 CTGACTACAATGAGAAGTTCAAGAACAAGGCCACACTGACTGTAGCCAAATCCTCCAG 
               
               
                   
               
               
                 CACAGCCTACATGCAACTCAGCAGCCTGACATCTGAGGACTCTGCGGTCTATTACTGT 
               
               
                   
               
               
                 GCAAGAGGAGATTACTACGGTAGTAGCTCGTTTGCTTACTGGGGCCAAGGGACTCTGG 
               
               
                   
               
               
                 TCACTGTCTCTGCAGCCAAAACAAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTGCTCC 
               
               
                   
               
               
                 AGGAGCACCTCCGAGAGCACAGCCGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG 
               
               
                   
               
               
                 AACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCC 
               
               
                   
               
               
                 GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCA 
               
               
                   
               
               
                 GCAGCTTGGGCACGAAGACCTACACCTGCAACGTAGATCACAAGCCCAGCAACACCA 
               
               
                   
               
               
                 AGGTGGACAAGAGAGTTGAGTCCAAATATGGTCCCCCATGCCCACCCTGCCCAGCACC 
               
               
                   
               
               
                 TGAGTTCGAAGGGGGACCATCAGTCTTCCTGTTCCCCCCAAAACCCAAGGACACTCTC 
               
               
                   
               
               
                 ATGATCTCCCGGACCCCTGAGGTCACGTGCGTGGTGGTGGACGTGAGCCAGGAAGACC 
               
               
                   
               
               
                 CCGAGGTCCAGTTCAACTGGTACGTGGATGGCGTGGAGGTGCATAATGCCAAGACAA 
               
               
                   
               
               
                 AGCCGCGGGAGGAGCAGTTCAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCT 
               
               
                   
               
               
                 GCACCAGGACTGGCTGAACGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGGCCT 
               
               
                   
               
               
                 CCCGTCCTCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAGCCACA 
               
               
                   
               
               
                 GGTGTACACCCTGCCCCCATCCCAGGAGGAGATGACCAAGAACCAGGTCAGCCTGAC 
               
               
                   
               
               
                 CTGCCTGGTCAAAGGCTTCTACCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGG 
               
               
                   
               
               
                 CAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCT 
               
               
                   
               
               
                 TCCTCTACAGCAGGCTAACCGTGGACAAGAGCAGGTGGCAGGAGGGGAATGTCTTCTC 
               
               
                   
               
               
                 ATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACACAGAAGAGCCTCTCCCTG 
               
               
                   
               
               
                 TCTCTGGGTAAAGCTAGCGGATGGAGCTATATCATCCTCTTTTTGGTAGCAACAGCTAC 
               
               
                   
               
               
                 AGATGTCCACTCCCAGGTCCAACTGCAGCAGCCTGGGGCTGAACTGGTGAAGCCTGGG 
               
               
                   
               
               
                 GCTTCAGTGAAGCTGTCCTGCAAGGCTTCTGGCTACACCTTCACCAGCTACTGGATGC 
               
               
                   
               
               
                 ACTGGGTGAAGCAGAGGCCTGGAGAAGGCCTTGAGTGGATTGGAGAGATTAATCCTA 
               
               
                   
               
               
                 GCTACGGTCGTACTGACTACAATGGGAAGTTCAAGAACAAGGCCACACTGACTGTAGC 
               
               
                   
               
               
                 CAAATCCTCCAGCACAGCCTACATGCAACTCAGCAGCCTGACATCTGAGGACTCTGCG 
               
               
                   
               
               
                 GTCTATTACTGTGCAAGAGGAGATTACTACGGTAGTAGCTCGTTTGCTTACTGGGGCC 
               
               
                   
               
               
                 AAGGGACTCTGGTCACTGTCTCTGCAGCCAAAACAAAGGGCCCATCCGTCTTCCCCCT 
               
               
                   
               
               
                 GGCGCCCTGCTCCAGGAGCACCTCCGAGAGCACAGCCGCCCTGGGCTGCCTGGTCAAG 
               
               
                   
               
               
                 GACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCG 
               
               
                   
               
               
                 TGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTG 
               
               
                   
               
               
                 ACCGTGCCCTCCAGCAGCTTGGGCACGAAGACCTACACCTGCAACGTAGATCACAAGC 
               
               
                   
               
               
                 CCAGCAACACCAAGGTGGACAAGAGAGTTGAGTCCAAATATGGTCCCCCATGCCCAC 
               
               
                   
               
               
                 CCTGCCCAGCACCTGAGTTCGAAGGGGGACCATCAGTCTTCCTGTTCCCCCCAAAACC 
               
               
                   
               
               
                 CAAGGACACTCTCATGATCTCCCGGACCCCTGAGGTCACGTGCGTGGTGGTGGACGTG 
               
               
                   
               
               
                 AGCCAGGAAGACCCCGAGGTCCAGTTCAACTGGTACGTGGATGGCGTGGAGGTGCAT 
               
               
                   
               
               
                 AATGCCAAGACAAAGCCGCGGGAGGAGCAGTTCAACAGCACGTACCGTGTGGTCAGC 
               
               
                   
               
               
                 GTCCTCACCGTCCTGCACCAGGACTGGCTGAACGGCAAGGAGTACAAGTGCAAGGTCT 
               
               
                   
               
               
                 CCAACAAAGGCCTCCCGTCCTCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGC 
               
               
                   
               
               
                 CCCGAGAGCCACAGGTGTACACCCTGCCCCCATCCCAGGAGGAGATGACCAAGAACC 
               
               
                   
               
               
                 AGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTACCCCAGCGACATCGCCGTGGAGTG 
               
               
                   
               
               
                 GGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTC 
               
               
                   
               
               
                 CGACGGCTCCTTCTTCCTCTACAGCAGGCTAACCGTGGACAAGAGCAGGTGGCAGGAG 
               
               
                   
               
               
                 GGGAATGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACACAGA 
               
               
                   
               
               
                 AGAGCCTCTCCCTGTCTCTGGGTAAAGCTAGCTGA 
               
               
                   
               
               
                 Anti-DCIR_29G10.3D9_H-V-hIgG4H-C (SEQ ID NO: 59): 
               
               
                 MMGWSYIILFLVATATDVHSQVQLQQPGAELVKPGASVKLSCKASGYTFTSYWMHWVK 
               
               
                   
               
               
                 QRPGEGLEWIGEINPSYGRTDYNEKFKNKATLTVAKSSSTAYMQLSSLTSEDSAVYYCAR 
               
               
                   
               
               
                 GDYYGSSSFAYWGQGTLVTVSAAKTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVT 
               
               
                   
               
               
                 VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRV 
               
               
                   
               
               
                 ESKYGPPCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYV 
               
               
                   
               
               
                 DGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKA 
               
               
                   
               
               
                 KGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLD 
               
               
                   
               
               
                 SDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGKAS 
               
               
                   
               
               
                 Anti-DCIR_29G10.3D9_K-Var1-V-hIgGK-C (SEQ ID NO: 60): 
               
               
                 ATGGATTTTCAAGTGCAGATTTTCAGCTTCCTGCTAATGAGTGCCTCAGTCATAATGTC 
               
               
                   
               
               
                 CAGGGGACAAATTGTTCTCACCCAGTCTCCAGCACTCATGTCTGCATCTCCAGGGGAG 
               
               
                   
               
               
                 AAGGTCACCATGACCTGCAGTGCCAGCTCAAATATAAGTTACATGTACTGGTACCAGC 
               
               
                   
               
               
                 AGAAGCCAAGATCCTCCCCCAAACCCTGGATTTATCTCACATCCAACCTGGCTTCTGG 
               
               
                   
               
               
                 AGTCCCTGCTCGCTTCAGTGGCAGTGGGTCTGGGACCTCTTACTCTCTCACAACCAGCA 
               
               
                   
               
               
                 GCATGGAGGCTGAAGATGCTGCCACTTATTGCTGCCAGCAGTGGAGTAGTAACCCACC 
               
               
                   
               
               
                 CACGTTCGGTGCTGGGACCAAGCTCGAGATCAAACGAACTGTGGCTGCACCATCTGTC 
               
               
                   
               
               
                 TTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCT 
               
               
                   
               
               
                 GCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTC 
               
               
                   
               
               
                 CAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTAC 
               
               
                   
               
               
                 AGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTAT 
               
               
                   
               
               
                 GCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGG 
               
               
                   
               
               
                 GAGAGTGTTAG 
               
               
                   
               
               
                 Anti-DCIR_29G10.3D9_K-Var1-V-hIgGK-C (SEQ ID NO: 61): 
               
               
                 MDFQVQIFSFLLMSASVIMSRGQIVLTQSPALMSASPGEKVTMTCSASSNISYMYWYQQKP 
               
               
                   
               
               
                 RSSPKPWIYLTSNLASGVPARFSGSGSGTSYSLTTSSMEAEDAATYCCQQWSSNPPTFGAG 
               
               
                   
               
               
                 TKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQES 
               
               
                   
               
               
                 VTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 Anti-DCIR_29G10.3D9_K-Var2-V-hIgGK-C (SEQ ID NO: 62): 
               
               
                 ATGGATTTTCGAGTGCAGATTTTCAGCTTCCTGCTAATGAGTGCCTCAGTCATAATGTC 
               
               
                   
               
               
                 CAGGGGACAAATTGTTCTCACCCAGTCTCCAGCACTCATGTCTGCATCTCCAGGGGAG 
               
               
                   
               
               
                 AAGGTCACCATGACCTGCAGTGCCAGCTCAAATATAAGTTACATGTACTGGTACCAGC 
               
               
                   
               
               
                 AGAAGCCAAGATCCTCCCCCAAACCCTGGATTTATCTCACATCCAACCTGGCTTCTGG 
               
               
                   
               
               
                 AGTCCCTGCTCGCTTCAGTGGCAGTGGGTCTGGGACCTCTTACTCTCTCACAATCAGCA 
               
               
                   
               
               
                 GCATGGAGGCTGAAGATGCTGCCACTTATTACTGCCAGCAGTGGAGTAGTAACCCACC 
               
               
                   
               
               
                 CACGTTCGGTGCTGGGACCAAGCTCGAGATCAAACGAACTGTGGCTGCACCATCTGTC 
               
               
                   
               
               
                 TTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCT 
               
               
                   
               
               
                 GCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTC 
               
               
                   
               
               
                 CAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTAC 
               
               
                   
               
               
                 AGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTAT 
               
               
                   
               
               
                 GCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGG 
               
               
                   
               
               
                 GAGAGTGTTAG 
               
               
                   
               
               
                 Anti-DCIR_29G10.3D9_K-Var2-V-hIgGK-C (SEQ ID NO: 63): 
               
               
                 MDFRVQIFSFLLMSASVIMSRGQIVLTQSPALMSASPGEKVTMTCSASSNISYMYWYQQKP 
               
               
                   
               
               
                 RSSPKPWIYLTSNLASGVPARFSGSGSGTSYSLTISSMEAEDAATYYCQQWSSNPPTFGAGT 
               
               
                   
               
               
                 KLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESV 
               
               
                   
               
               
                 TEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 Anti-DCIR_2C9K-V-hIgGK-C (SEQ ID NO: 64): 
               
               
                 ATGGAGACAGACACACTCCTGCTATGGGTGCTGCTGCTCTGGGTTCCAGGTTCCACAG 
               
               
                   
               
               
                 GTGACATTGTGCTGATCCAATCTCCAGCTTCTTTGGCTGTGTCTCTAGGGCAGAGGGCC 
               
               
                   
               
               
                 ACCATATCCTGCAGAGCCAGTGAAAGTGTTGATAGTTATGTCAATAGTTTTATGCACT 
               
               
                   
               
               
                 GGTACCAGCAGAAACCAGGACAGCCACCCAAACTCCTCATCTATCGTGTATCCAACCT 
               
               
                   
               
               
                 AGAATCTGGGATCCCTGCCAGGTTCAGTGGCAGTGGGTCTAGGACAGACTTCACCCTC 
               
               
                   
               
               
                 ACCATTAATCCTGTGGAGGCTGATGATGTTGCAACCTATTACTGTCAGCAAAGTAATG 
               
               
                   
               
               
                 AGGATCCATTCACGTTCGGCTCGGGGACAAAGCTCGAGATCAAACGAACTGTGGCTGC 
               
               
                   
               
               
                 ACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTG 
               
               
                   
               
               
                 TTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGA 
               
               
                   
               
               
                 TAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGA 
               
               
                   
               
               
                 CAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACA 
               
               
                   
               
               
                 CAAAGTCTATGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGC 
               
               
                   
               
               
                 TTCAACAGGGGAGAGTGTTAG 
               
               
                   
               
               
                 Anti-DCIR_2C9K-V-hIgGK-C (SEQ ID NO: 65): 
               
               
                 METDTLLLWVLLLWVPGSTGDIVLIQSPASLAVSLGQRATISCRASESVDSYVNSFMHWY 
               
               
                   
               
               
                 QQKPGQPPKLLIYRVSNLESGIPARFSGSGSRTDFTLTINPVEADDVATYYCQQSNEDPFTF 
               
               
                   
               
               
                 GSGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNS 
               
               
                   
               
               
                 QESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC. 
               
               
                   
               
               
                 Anti-DCIR_31A6.1F5_H-var2-V-hIgG4H-C (SEQ ID NO: 66): 
               
               
                 ATGGAATGTAACTGGATACTTCCTTTTATTCTGTCGGTAATTTCAGGGGTCTACTCAGA 
               
               
                   
               
               
                 GGTTCAGCTCCAGCAGTCTGGGACTGTGCTGGCAAGGCCTGGGGCTTCCGTGAATATG 
               
               
                   
               
               
                 TCCTGTAAGGCTGCTGGCTACAGCTTTACCAGTTACTGGGTGTACTGGGTCAAACAGA 
               
               
                   
               
               
                 GGCCTGGACAGGGTCTGGAATGGATTGGTGCTATTTACCCTAAAAATAGTAGAACTAG 
               
               
                   
               
               
                 CTACAACCAGAAGTTCCAGGACAAGGCCACACTGACTGCAGTCACATCCGCCAGCACT 
               
               
                   
               
               
                 GCCTACATGGAGCTCAGCAGCCTGACAAATGAGGACTCTGCGGTCTATTACTGTACAA 
               
               
                   
               
               
                 GACCTCACTATGATTCGTTTGGTTACTGGGGCCAAGGGACTCTGGTCACTGTCTCTGCA 
               
               
                   
               
               
                 GCCAAAACAaagggcccATCCGTCTTCCCCCTGGCGCCCTGCTCCAGGAGCACCTCCGAGA 
               
               
                   
               
               
                 GCACAGCCGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTC 
               
               
                   
               
               
                 GTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCC 
               
               
                   
               
               
                 TCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACGA 
               
               
                   
               
               
                 AGACCTACACCTGCAACGTAGATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAG 
               
               
                   
               
               
                 TTGAGTCCAAATATGGTCCCCCATGCCCACCCTGCCCAGCACCTGAGTTCGAAGGGGG 
               
               
                   
               
               
                 ACCATCAGTCTTCCTGTTCCCCCCAAAACCCAAGGACACTCTCATGATCTCCCGGACCC 
               
               
                   
               
               
                 CTGAGGTCACGTGCGTGGTGGTGGACGTGAGCCAGGAAGACCCCGAGGTCCAGTTCA 
               
               
                   
               
               
                 ACTGGTACGTGGATGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGC 
               
               
                   
               
               
                 AGTTCAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCT 
               
               
                   
               
               
                 GAACGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGGCCTCCCGTCCTCCATCGA 
               
               
                   
               
               
                 GAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAGCCACAGGTGTACACCCTGCC 
               
               
                   
               
               
                 CCCATCCCAGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGG 
               
               
                   
               
               
                 CTTCTACCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAA 
               
               
                   
               
               
                 CTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTACAGCAGGC 
               
               
                   
               
               
                 TAACCGTGGACAAGAGCAGGTGGCAGGAGGGGAATGTCTTCTCATGCTCCGTGATGCA 
               
               
                   
               
               
                 TGAGGCTCTGCACAACCACTACACACAGAAGAGCCTCTCCCTGTCTCTGGGTAAAGCT 
               
               
                   
               
               
                 AGCTGA 
               
               
                   
               
               
                 Anti-DCIR_31A6.1F5_H-var2-V-hIgG4H-C (SEQ ID NO: 67): 
               
               
                 MECNWILPFILSVISGVYSEVQLQQSGTVLARPGASVNMSCKAAGYSFTSYWVYWVKQRP 
               
               
                   
               
               
                 GQGLEWIGAIYPKNSRTSYNQKFQDKATLTAVTSASTAYMELSSLTNEDSAVYYCTRPHY 
               
               
                   
               
               
                 DSFGYWGQGTLVTVSAAKTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSG 
               
               
                   
               
               
                 ALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPP 
               
               
                   
               
               
                 CPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHN 
               
               
                   
               
               
                 AKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREP 
               
               
                   
               
               
                 QVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLY 
               
               
                   
               
               
                 SRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGKAS 
               
               
                   
               
               
                 Anti-DCIR_31A6.1F5_K-var2-V-hIgGK-C (SEQ ID NO: 68): 
               
               
                 ATGGAGACAGACACACTCCTGCTATGGGTGCTGCTGCTCTGGGTTCCAGGTTCCACAG 
               
               
                   
               
               
                 GTGACATTGTGCTGACCCAATCTCCAGCTTCTTTGGCTGTGTCTCTAGGGCAGAGGGCC 
               
               
                   
               
               
                 ACCATATCCTGCAGAGCCAGTGAAAGTGTAGATAGTTATGGCATTAGTTTTATGCACT 
               
               
                   
               
               
                 GGTACCAGCAGAAACCAGGACAGCCACCCAAACTCCTCATCTATCGTGCATCCAACCA 
               
               
                   
               
               
                 AGAATCTGGGATCCCTGCCAGGTTCAGTGGCAGTGGGTCTAGGACAGACTTCACCCTC 
               
               
                   
               
               
                 ACCATTAATCCTGTGGAGGCTGATGATGTTGCAACCTATTACTGTCAGCAAAGTAATG 
               
               
                   
               
               
                 AGGATCCGCTCACGTTCGGTGCTGGGACCAAGCTCGAGATCAAACGAACTGTGGCTGC 
               
               
                   
               
               
                 ACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTG 
               
               
                   
               
               
                 TTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGA 
               
               
                   
               
               
                 TAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGA 
               
               
                   
               
               
                 CAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACA 
               
               
                   
               
               
                 CAAAGTCTATGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGC 
               
               
                   
               
               
                 TTCAACAGGGGAGAGTGTTAG 
               
               
                   
               
               
                 Anti-DCIR_31A6.1F5_K-var2-V-hIgGK-C (SEQ ID NO: 69): 
               
               
                 METDTLLLWVLLLWVPGSTGDIVLTQSPASLAVSLGQRATISCRASESVDSYGISFMHWY 
               
               
                   
               
               
                 QQKPGQPPKLLIYRASNQESGIPARFSGSGSRTDFTLTINPVEADDVATYYCQQSNEDPLTF 
               
               
                   
               
               
                 GAGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGN 
               
               
                   
               
               
                 SQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 Anti-DCIR_3C2.2D9_H-LV-hIgG4H-C (SEQ ID NO: 70): 
               
               
                 ATGAACAGGCTTACTTCCTCATTGCTGCTGCTGATTGTCCCTGCATATGTCCTGTCCCA 
               
               
                   
               
               
                 GGTTACTCTGAAAGAGTCTGGCCCTGGGATATTGCAGCCCTCCCAGACCCTCAGTCTG 
               
               
                   
               
               
                 ACTTGTTCTTTCTCTGGGTTTTCACTGAGCACTTCTGGTATGGGTGTGAGCTGGATTCG 
               
               
                   
               
               
                 TCAGCCTTCAGGAAAGGGTCTGGAGTGGCTGGCACACATTTACTGGGATGATGACAAG 
               
               
                   
               
               
                 CGCTATAATCCATCCCTGAAGAGCCGGCTCACAATCTTTAAGGATCCCTCCAGCAACC 
               
               
                   
               
               
                 AGGTATTCCTCAGGATCACCAGTGTGGACACTGCAGATACTGCCACATACTACTGTGC 
               
               
                   
               
               
                 TCGAAACTCCCATTACTACGGTAGTACTTACGGGGGATACTTCGATGTCTGGGGCGCA 
               
               
                   
               
               
                 GGGACCACGGTCACCGTCTCCTCAGCCAAAACAAAGGGCCCATCCGTCTTCCCCCTGG 
               
               
                   
               
               
                 CGCCCTGCTCCAGGAGCACCTCCGAGAGCACAGCCGCCCTGGGCTGCCTGGTCAAGGA 
               
               
                   
               
               
                 CTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTG 
               
               
                   
               
               
                 CACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGAC 
               
               
                   
               
               
                 CGTGCCCTCCAGCAGCTTGGGCACGAAGACCTACACCTGCAACGTAGATCACAAGCCC 
               
               
                   
               
               
                 AGCAACACCAAGGTGGACAAGAGAGTTGAGTCCAAATATGGTCCCCCATGCCCACCCT 
               
               
                   
               
               
                 GCCCAGCACCTGAGTTCGAAGGGGGACCATCAGTCTTCCTGTTCCCCCCAAAACCCAA 
               
               
                   
               
               
                 GGACACTCTCATGATCTCCCGGACCCCTGAGGTCACGTGCGTGGTGGTGGACGTGAGC 
               
               
                   
               
               
                 CAGGAAGACCCCGAGGTCCAGTTCAACTGGTACGTGGATGGCGTGGAGGTGCATAAT 
               
               
                   
               
               
                 GCCAAGACAAAGCCGCGGGAGGAGCAGTTCAACAGCACGTACCGTGTGGTCAGCGTC 
               
               
                   
               
               
                 CTCACCGTCCTGCACCAGGACTGGCTGAACGGCAAGGAGTACAAGTGCAAGGTCTCCA 
               
               
                   
               
               
                 ACAAAGGCCTCCCGTCCTCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCC 
               
               
                   
               
               
                 GAGAGCCACAGGTGTACACCCTGCCCCCATCCCAGGAGGAGATGACCAAGAACCAGG 
               
               
                   
               
               
                 TCAGCCTGACCTGCCTGGTCAAAGGCTTCTACCCCAGCGACATCGCCGTGGAGTGGGA 
               
               
                   
               
               
                 GAGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGA 
               
               
                   
               
               
                 CGGCTCCTTCTTCCTCTACAGCAGGCTAACCGTGGACAAGAGCAGGTGGCAGGAGGGG 
               
               
                   
               
               
                 AATGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACACAGAAGA 
               
               
                   
               
               
                 GCCTCTCCCTGTCTCTGGGTAAAGCTAGCTGA 
               
               
                   
               
               
                 Anti-DCIR_3C2.2D9_H-LV-hIgG4H-C (SEQ ID NO: 71): 
               
               
                 NRLTSSLLLLIVPAYVLSQQVTLKESGPGILQPSQTLSLTCSFSGFSLSTSGMGVSWIRQPSG 
               
               
                   
               
               
                 KGLEWLAHIYWDDDKRYNPSLKSRLTIFKDPSSNQVFLRITSVDTADTATYYCARNSHYY 
               
               
                   
               
               
                 GSTYGGYFDVWGAGTTVTVSSAKTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVS 
               
               
                   
               
               
                 WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVES 
               
               
                   
               
               
                 KYGPPCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDG 
               
               
                   
               
               
                 VEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKG 
               
               
                   
               
               
                 QPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
               
               
                 GSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGKAS. 
               
               
                   
               
               
                 Anti-DCIR_3C2.2D9_K-LV-hIgGK-C (SEQ ID NO: 72): 
               
               
                 ATGGAGACAGACACACTCCTGCTATGGGTGCTGCTGCTCGGGGTTCCAGGTTCCACAG 
               
               
                   
               
               
                 GTAACATTGTGCTGACCCAGTCTCCAACTTCTTTCACTGTGTCTCTTGGGCAGAGGGCC 
               
               
                   
               
               
                 ACCATATCCTGCAGAGCCAGTGAAAGTGTTCATAGTTATGGCAATAGTTTTATGCACT 
               
               
                   
               
               
                 GGTACCAGCAGAAACCAGGGCAGCCACCCAAACTCCTCATCTATCTTGCATCCAACGT 
               
               
                   
               
               
                 AGAATCTGGGGTCCCTGCCAGGTTCAGTGGTAGTGGGTCCAGGACAGACTTCACCCTC 
               
               
                   
               
               
                 ACCATTGATCCTGTGGAGGCTGATGATGCTGCAACCTATTACTGTCAGCAAAATAGTG 
               
               
                   
               
               
                 AGGATCCGTGGACGTTCGGTGGAGGCACCAAGCTCGAGATCAAACGAACTGTGGCTG 
               
               
                   
               
               
                 CACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCT 
               
               
                   
               
               
                 GTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGG 
               
               
                   
               
               
                 ATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGG 
               
               
                   
               
               
                 ACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAAC 
               
               
                   
               
               
                 ACAAAGTCTATGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAG 
               
               
                   
               
               
                 CTTCAACAGGGGAGAGTGTTAG 
               
               
                   
               
               
                 Anti-DCIR_3C2.2D9_K-LV-hIgGK-C (SEQ ID NO: 73): 
               
               
                 METDTLLLWVLLLGVPGSTGNIVLTQSPTSFTVSLGQRATISCRASESVHSYGNSFMHWYQ 
               
               
                   
               
               
                 QKPGQPPKLLIYLASNVESGVPARFSGSGSRTDFTLTIDPVEADDAATYYCQQNSEDPWTF 
               
               
                   
               
               
                 GGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGN 
               
               
                   
               
               
                 SQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 Anti-DCIR_6C8.1G9_H-V-hIgG4H-C (SEQ ID NO: 74): 
               
               
                 ATGGAATGGACCTGGGTCTTTCTCTTCCTCCTGTCAGTAACTGCAGGTGTCCACTCCCA 
               
               
                   
               
               
                 GGTTCAGCTGCAGCAGTCTGGAACTGAGCTGATGAAGCCTGGGGCCTCAGTGAAGATA 
               
               
                   
               
               
                 TCCTGCAAGGCTACTGGCTACACATTCAGTACCTACTGGATAGAGTGGGTAAAGCAGA 
               
               
                   
               
               
                 GGCCTGGACATGGCCTTGAGTGGATTGGAGAGATTTTACCTGGAAGTGGTAGGACTAA 
               
               
                   
               
               
                 CGACAATGAGAAGTTCAAGGGCAAGGCCACAATCACTGCAGATACATCCTCCAAGAA 
               
               
                   
               
               
                 AGCCTACATGCAACTCAGCAGCCTGACATCTGAGGACTCTGCCGTCTATTACTGTGCA 
               
               
                   
               
               
                 AGAAGGGGTGGTTACTCCTTTGCTTTCTGGGGCCAAGGGACTCTGGTCTCTGTCTCTGC 
               
               
                   
               
               
                 AGCCAAAACAAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTGCTCCAGGAGCACCTCC 
               
               
                   
               
               
                 GAGAGCACAGCCGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGG 
               
               
                   
               
               
                 TGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACA 
               
               
                   
               
               
                 GTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGC 
               
               
                   
               
               
                 ACGAAGACCTACACCTGCAACGTAGATCACAAGCCCAGCAACACCAAGGTGGACAAG 
               
               
                   
               
               
                 AGAGTTGAGTCCAAATATGGTCCCCCATGCCCACCCTGCCCAGCACCTGAGTTCGAAG 
               
               
                   
               
               
                 GGGGACCATCAGTCTTCCTGTTCCCCCCAAAACCCAAGGACACTCTCATGATCTCCCG 
               
               
                   
               
               
                 GACCCCTGAGGTCACGTGCGTGGTGGTGGACGTGAGCCAGGAAGACCCCGAGGTCCA 
               
               
                   
               
               
                 GTTCAACTGGTACGTGGATGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGA 
               
               
                   
               
               
                 GGAGCAGTTCAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGAC 
               
               
                   
               
               
                 TGGCTGAACGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGGCCTCCCGTCCTCCA 
               
               
                   
               
               
                 TCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAGCCACAGGTGTACACCC 
               
               
                   
               
               
                 TGCCCCCATCCCAGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAA 
               
               
                   
               
               
                 AGGCTTCTACCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAA 
               
               
                   
               
               
                 CAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTACAGCA 
               
               
                   
               
               
                 GGCTAACCGTGGACAAGAGCAGGTGGCAGGAGGGGAATGTCTTCTCATGCTCCGTGAT 
               
               
                   
               
               
                 GCATGAGGCTCTGCACAACCACTACACACAGAAGAGCCTCTCCCTGTCTCTGGGTAAA 
               
               
                   
               
               
                 GCTAGCTGA 
               
               
                   
               
               
                 Anti-DCIR_6C8.1G9_H-V-hIgG4H-C (SEQ ID NO: 75): 
               
               
                 MEWTWVFLFLLSVTAGVHSQVQLQQSGTELMKPGASVKISCKATGYTFSTYWIEWVKQR 
               
               
                   
               
               
                 PGHGLEWIGEILPGSGRTNDNEKFKGKATITADTSSKKAYMQLSSLTSEDSAVYYCARRG 
               
               
                   
               
               
                 GYSFAFWGQGTLVSVSAAKTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNS 
               
               
                   
               
               
                 GALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGP 
               
               
                   
               
               
                 PCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVH 
               
               
                   
               
               
                 NAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPRE 
               
               
                   
               
               
                 PQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL 
               
               
                   
               
               
                 YSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGKAS 
               
               
                   
               
               
                 Anti-DCIR_6C8.1G9_K-V-hIgGK-C (SEQ ID NO: 76): 
               
               
                 ATGACCATGTTCTCACTAGCTCTTCTCCTCAGTCTTCTTCTCCTCTGTGTCTCTGATTCT 
               
               
                   
               
               
                 AGGGCAGAAACAACTGTGACCCAGTCTCCAGCATCCCTGTCCATGGCTATAGGAGAAA 
               
               
                   
               
               
                 AAGTCACCATCAGATGCGTAACCAGCACTGATATTGATGATGATGTGAACTGGTACCA 
               
               
                   
               
               
                 GCAGAAGCCAGGGGAACCTCCTAAGCTCCTTATTTCAGAAGGCAATACTCTTCGTGCT 
               
               
                   
               
               
                 GGAGTCCCATCCCGATTCTCCAGCAGTGGCTATGGTACAGATTTTGTTTTTACAATTGA 
               
               
                   
               
               
                 GAACATGCTCTCAGAAGATGTTGCAGATTACTACTGTTTGCAAAGTGGTAACTTGCCG 
               
               
                   
               
               
                 TACACGTTCGGAGGGGGGACCAAGCTCGAGATCAAACGAACTGTGGCTGCACCATCT 
               
               
                   
               
               
                 GTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTG 
               
               
                   
               
               
                 CCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCC 
               
               
                   
               
               
                 CTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACC 
               
               
                   
               
               
                 TACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTC 
               
               
                   
               
               
                 TATGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACA 
               
               
                   
               
               
                 GGGGAGAGTGTTAG 
               
               
                   
               
               
                 Anti-DCIR_6C8.1G9_K-V-hIgGK-C (SEQ ID NO: 77): 
               
               
                 MTMFSLALLLSLLLLCVSDSRAETTVTQSPASLSMAIGEKVTIRCVTSTDIDDDVNWYQQK 
               
               
                   
               
               
                 PGEPPKLLISEGNTLRAGVPSRFSSSGYGTDFVFTIENMLSEDVADYYCLQSGNLPYTFGGG 
               
               
                   
               
               
                 TKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQES 
               
               
                   
               
               
                 VTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 Anti-DCIR_9E8.1E3_H-V-hIgG4H-C (SEQ ID NO: 78): 
               
               
                 ATGAACAGGCTTACTTCCTCATTGCTGCTGCTGATTGTCCCTGCATATGTCCTGTCCCA 
               
               
                   
               
               
                 GGTTACTCTGAAAGAGTCTGGCCCTGGGATATTGCAGCCCTCCCAGACCCTCAGTCTG 
               
               
                   
               
               
                 ACTTGTTCTTTCTCTGGGTTTTCACTGAGCACTTCTGGTATGGGTCTGAGCTGGATTCGT 
               
               
                   
               
               
                 CAGCCTTCAGGAAAGGGTCTGGAGTGGCTGGCACACATTTACTGGGATGATGACAAGC 
               
               
                   
               
               
                 GCTATAACCCATCCCTGAAGAGCCGGCTCACAATCTCCAAGGATACCTCCAGCAACCA 
               
               
                   
               
               
                 GGTTTTCCTCAAGATCACCATTGTGGACACTGCAGATGCTGCCACATACTACTGTGCTC 
               
               
                   
               
               
                 GAAGCTCCCATTACTACGGTTATGGCTACGGGGGATACTTCGATGTCTGGGGCGCAGG 
               
               
                   
               
               
                 GACCACGGTCACCGTCTCCTCAGCCAAAACGAAGGGCCCATCCGTCTTCCCCCTGGCG 
               
               
                   
               
               
                 CCCTGCTCCAGGAGCACCTCCGAGAGCACAGCCGCCCTGGGCTGCCTGGTCAAGGACT 
               
               
                   
               
               
                 ACTTCCCCGAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCA 
               
               
                   
               
               
                 CACCTTCCCGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCG 
               
               
                   
               
               
                 TGCCCTCCAGCAGCTTGGGCACGAAGACCTACACCTGCAACGTAGATCACAAGCCCAG 
               
               
                   
               
               
                 CAACACCAAGGTGGACAAGAGAGTTGAGTCCAAATATGGTCCCCCATGCCCACCCTGC 
               
               
                   
               
               
                 CCAGCACCTGAGTTCGAAGGGGGACCATCAGTCTTCCTGTTCCCCCCAAAACCCAAGG 
               
               
                   
               
               
                 ACACTCTCATGATCTCCCGGACCCCTGAGGTCACGTGCGTGGTGGTGGACGTGAGCCA 
               
               
                   
               
               
                 GGAAGACCCCGAGGTCCAGTTCAACTGGTACGTGGATGGCGTGGAGGTGCATAATGC 
               
               
                   
               
               
                 CAAGACAAAGCCGCGGGAGGAGCAGTTCAACAGCACGTACCGTGTGGTCAGCGTCCT 
               
               
                   
               
               
                 CACCGTCCTGCACCAGGACTGGCTGAACGGCAAGGAGTACAAGTGCAAGGTCTCCAA 
               
               
                   
               
               
                 CAAAGGCCTCCCGTCCTCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCG 
               
               
                   
               
               
                 AGAGCCACAGGTGTACACCCTGCCCCCATCCCAGGAGGAGATGACCAAGAACCAGGT 
               
               
                   
               
               
                 CAGCCTGACCTGCCTGGTCAAAGGCTTCTACCCCAGCGACATCGCCGTGGAGTGGGAG 
               
               
                   
               
               
                 AGCAATGGGCAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGAC 
               
               
                   
               
               
                 GGCTCCTTCTTCCTCTACAGCAGGCTAACCGTGGACAAGAGCAGGTGGCAGGAGGGG 
               
               
                   
               
               
                 AATGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACACAGAAGA 
               
               
                   
               
               
                 GCCTCTCCCTGTCTCTGGGTAAAGCTAGCTGA 
               
               
                   
               
               
                 Anti-DCIR_9E8.1E3_H-V-hIgG4H-C (SEQ ID NO: 79): 
               
               
                 MNRLTSSLLLLIVPAYVLSQVTLKESGPGILQPSQTLSLTCSFSGFSLSTSGMGLSWIRQPSG 
               
               
                   
               
               
                 KGLEWLAHIYWDDDKRYNPSLKSRLTISKDTSSNQVFLKITIVDTADAATYYCARSSHYY 
               
               
                   
               
               
                 GYGYGGYFDVWGAGTTVTVSSAKTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTV 
               
               
                   
               
               
                 SWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVES 
               
               
                   
               
               
                 KYGPPCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDG 
               
               
                   
               
               
                 VEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKG 
               
               
                   
               
               
                 QPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
               
               
                 GSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGKAS 
               
               
                   
               
               
                 Anti-DCIR_9E8.1E3_K-LV-hIgGK-C (SEQ ID NO: 80): 
               
               
                 ATGGAGACAGACACACTCCTGCTATGGGTGCTGCTGCTCTGGGTTCCAGGTTCCACAG 
               
               
                   
               
               
                 GTAACATTGTGCTGACCCAATCTCCAGCTTCTTTGGCTGTGTCTCTAGGGCAGAGGGCC 
               
               
                   
               
               
                 ACCATATCCTGCAGAGCCAGTGAAAGTATTCATAGTTATGGCAATAGTTTTCTGCACT 
               
               
                   
               
               
                 GGTACCAGCAGAAACCAGGACAGCCACCCAAACTCCTCATCTATCTTGCATCCAACCT 
               
               
                   
               
               
                 AGAATCTGGGGTCCCTGCCAGGTTCAGCGGCAGTGGGTCTAGGACAGACTTCACCCTC 
               
               
                   
               
               
                 ACCATTGATCCTGTGGAGGCTGATGATGCTGCAACCTATTACTGTCAGCAAAATAATG 
               
               
                   
               
               
                 AGGATCCGTGGACGTTCGGTGGAGGCACCAAGCTCGAGATCAAACGAACTGTGGCTG 
               
               
                   
               
               
                 CACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCT 
               
               
                   
               
               
                 GTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGG 
               
               
                   
               
               
                 ATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGG 
               
               
                   
               
               
                 ACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAAC 
               
               
                   
               
               
                 ACAAAGTCTATGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAG 
               
               
                   
               
               
                 CTTCAACAGGGGAGAGTGTTAGGCGGCCGCACTAGCGCGGGCCGCATTCGAAGAGCT 
               
               
                   
               
               
                 CGGTACCCGGGGATCCTCTAGAGTCGACCTGCAGGCATGCAAGCTGGCCGCGACTCTA 
               
               
                   
               
               
                 GATCATAATCAGC 
               
               
                   
               
               
                 Anti-DCIR_9E8.1E3_K-LV-hIgGK-C (SEQ ID NO: 81): 
               
               
                 METDTLLLWVLLLWVPGSTGNIVLTQSPASLAVSLGQRATISCRASESIHSYGNSFLHWYQ 
               
               
                   
               
               
                 QKPGQPPKLLIYLASNLESGVPARFSGSGSRTDFTLTIDPVEADDAATYYCQQNNEDPWTF 
               
               
                   
               
               
                 GGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGN 
               
               
                   
               
               
                 SQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 Anti-DCIR2C9H-LV-hIgG4H-V-hIgG4H-C (SEQ ID NO: 82): 
               
               
                   
               
               
                 ATGAAATGCAGCTGGGTCATCTTCTTCCTGATGGCAGTGGTTACAGGGGTCAATTCAG 
               
               
                   
               
               
                 AGGTTCAGCTGCAGCAGTCTGGGGCTGAGCTTGTGAGGCCAGGGGCCTTAGTCAAGTT 
               
               
                   
               
               
                 GTCCTGCAAAGCTTCTGGCTTCAACATTAATGACTACTATATCCACTGGGTGAAGCAG 
               
               
                   
               
               
                 CGGCCTGAACAGGGCCTGGAGCGGATTGGATGGATTGATCCTGACAATGGTAATACTA 
               
               
                   
               
               
                 TATATGACCCGAAGTTCCAGGGCAAGGCCAGTATAACAGCAGACACATCCCCCAACA 
               
               
                   
               
               
                 CAGCCTACCTGCAGCTCAGCAGCCTGACATCTGAGGACACTGCCGTCTATTACTGTGC 
               
               
                   
               
               
                 TAGAACCCGATCTCCTATGGTTACGACGGGGTTTGTTTACTGGGGCCAAGGGACTGTG 
               
               
                   
               
               
                 GTCACTGTCTCTGCAGCCAAAACGAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTGCTC 
               
               
                   
               
               
                 CAGGAGCACCTCCGAGAGCACAGCCGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCC 
               
               
                   
               
               
                 GAACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCC 
               
               
                   
               
               
                 CGGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCC 
               
               
                   
               
               
                 AGCAGCTTGGGCACGAAGACCTACACCTGCAACGTAGATCACAAGCCCAGCAACACC 
               
               
                   
               
               
                 AAGGTGGACAAGAGAGTTGAGTCCAAATATGGTCCCCCATGCCCACCCTGCCCAGCAC 
               
               
                   
               
               
                 CTGAGTTCGAAGGGGGACCATCAGTCTTCCTGTTCCCCCCAAAACCCAAGGACACTCT 
               
               
                   
               
               
                 CATGATCTCCCGGACCCCTGAGGTCACGTGCGTGGTGGTGGACGTGAGCCAGGAAGAC 
               
               
                   
               
               
                 CCCGAGGTCCAGTTCAACTGGTACGTGGATGGCGTGGAGGTGCATAATGCCAAGACRA 
               
               
                   
               
               
                 AGCCGCGGGAGGAGCAGTTCAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCT 
               
               
                   
               
               
                 GCACCAGGACTGGCTGAACGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGGCCT 
               
               
                   
               
               
                 CCCGTCCTCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAGCCACA 
               
               
                   
               
               
                 GGTGTACACCCTGCCCCCATCCCAGGAGGAGATGACCAAGAACCAGGTCAGCCTGAC 
               
               
                   
               
               
                 CTGCCTGGTCAAAGGCTTCTACCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGG 
               
               
                   
               
               
                 CAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCT 
               
               
                   
               
               
                 TCCTCTACAGCAGGCTAACCGTGGACAAGAGCAGGTGGCAGGAGGGGAATGTCTTCTC 
               
               
                   
               
               
                 ATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACACAGAAGAGCCTCTCCCTG 
               
               
                   
               
               
                 TCTCTGGGTAAATGA 
               
               
                   
               
               
                 Anti-DCIR2C9H-LV-hIgG4H-V-hIgG4H-C (SEQ ID NO: 83): 
               
               
                 MKCSWVIFFLMAVVTGVNSEVQLQQSGAELVRPGALVKLSCKASGFNINDYYIHWVKQR 
               
               
                   
               
               
                 PEQGLERIGWIDPDNGNTIYDPKFQGKASITADTSPNTAYLQLSSLTSEDTAVYYCARTRSP 
               
               
                   
               
               
                 MVTTGFVYWGQGTVVTVSAAKTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSW 
               
               
                   
               
               
                 NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKY 
               
               
                   
               
               
                 GPPCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVE 
               
               
                   
               
               
                 VHNAKXKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQP 
               
               
                   
               
               
                 REPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSF 
               
               
                   
               
               
                 FLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGK 
               
               
                   
               
               
                 Anti-DC-SIGNL16E3H (SEQ ID NO: 84): 
               
               
                 ATGGAAAGGCACTGGATCTTTCTCTTCCTGTTTTCAGTAACTGCAGGTGTCCACTCCCA 
               
               
                   
               
               
                 GGTCCAGCTTCAGCAGTCTGGGGCTGAGCTGGCAAAACCTGGGGCCTCAGTGAAGATG 
               
               
                   
               
               
                 TCCTGCAAGGCTTCTGGCTACACCTTTACTACCTACTGGATGCACTGGGTAAAACAGA 
               
               
                   
               
               
                 GGCCTGGACAGGGTCTGGAATGGATTGGATACATTAATCCTATCACTGGTTATACTGA 
               
               
                   
               
               
                 GTACAATCAGAAGTTCAAGGACAAGGCCACCTTGACTGCAGACAAATCCTCCAGCAC 
               
               
                   
               
               
                 AGCCTACATGCAACTGAGCAGCCTGACATCTGAGGACTCTGCAGTCTATTACTGTGCA 
               
               
                   
               
               
                 AGAGAGGGTTTAAGTGCTATGGACTATTGGGGTCAGGGAACCTCAGTCACCGTCACCT 
               
               
                   
               
               
                 CAGCCAAAACAACAGCCCCATCGGTCTATCCACTGGCCCCTGTGTGTGGAGATACAAC 
               
               
                   
               
               
                 TGGCTCCTCGGTAACTCTAGGATGCCTGGTCAAGGGTTATTTCCCTGAGCCAGTGACCT 
               
               
                   
               
               
                 TGACCTGGAACTCTGGATCCCTGTCCAGTGGTGTGCACACCTTCCCAGCTGTCCTGCAG 
               
               
                   
               
               
                 TCTGACCTCTACACCCTCAGCAGCTCAGTGACTGTAACCTCGAGCACCTGGCCCAGCC 
               
               
                   
               
               
                 AGACCGTCACCTGCAGCGTTGCTCACCCAGCCAGCAGCACCACGGTGGACAAAAAAC 
               
               
                   
               
               
                 TTGAGCCCAGCGGGCCCATTTCAACAATCAACCCCTGTCCTCCATGCAAGGAGTGTCA 
               
               
                   
               
               
                 CAAATGCCCAGCTCCTAACCTCGAGGGTGGACCATCCGTCTTCATCTTCCCTCCAAATA 
               
               
                   
               
               
                 TCAAGGATGTACTCATGATCTCCCTGACACCCAAGGTCACGTGTGTGGTGGTGGATGT 
               
               
                   
               
               
                 GAGCGAGGATGACCCAGACGTCCAGATCAGCTGGTTTGTGAACAACGTGGAAGTACA 
               
               
                   
               
               
                 CACAGCTCAGACACAAACCCATAGAGAGGATTACAACAGTACTATCCGGGTGGTCAG 
               
               
                   
               
               
                 CACCCTCCCCATCCAGCACCAGGACTGGATGAGTGGCAAGGAGTTCAAATGCAAGGTC 
               
               
                   
               
               
                 AACAACAAAGACCTCCCATCACCCATCGAGAGAACCATCTCAAAAATTAAAGGGCTA 
               
               
                   
               
               
                 GTCAGAGCTCCACAAGTATACATCTTGCCGCCACCAGCAGAGCAGTTGTCCAGGAAAG 
               
               
                   
               
               
                 ATGTCAGTCTCACTTGCCTGGTCGTGGGCTTCAACCCTGGAGACATCAGTGTGGAGTG 
               
               
                   
               
               
                 GACCAGCAATGGGCATACAGAGGAGAACTACAAGGACACCGCACCAGTCCTGGACTC 
               
               
                   
               
               
                 TGACGGTTCTTACTTCATATATAGCAAGCTCAATATGAAAACAAGCAAGTGGGAGAAA 
               
               
                   
               
               
                 ACAGATTCCTTCTCATGCAACGTGAGACACGAGGGTCTGAAAAATTACTACCTGAAGA 
               
               
                   
               
               
                 AGACCATCTCCCGGTCTCCGGGTAAAGCTAGCTGA 
               
               
                   
               
               
                 Anti-DC-SIGNL16E3H (SEQ ID NO: 85): 
               
               
                 MERHWIFLFLFSVTAGVHSQVQLQQSGAELAKPGASVKMSCKASGYTFTTYWMHWVKQ 
               
               
                   
               
               
                 RPGQGLEWIGYINPITGYTEYNQKFKDKATLTADKSSSTAYMQLSSLTSEDSAVYYCAREG 
               
               
                   
               
               
                 LSAMDYWGQGTSVTVTSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNS 
               
               
                   
               
               
                 GSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQTVTCSVAHPASSTTVDKKLEPSGPISTI 
               
               
                   
               
               
                 NPCPPCKECHKCPAPNLEGGPSVFIFPPNIKDVLMISLTPKVTCVVVDVSEDDPDVQISWFV 
               
               
                   
               
               
                 NNVEVHTAQTQTHREDYNSTIRVVSTLPIQHQDWMSGKEFKCKVNNKDLPSPIERTISKIK 
               
               
                   
               
               
                 GLVRAPQVYILPPPAEQLSRKDVSLTCLVVGFNPGDISVEWTSNGHTEENYKDTAPVLDSD 
               
               
                   
               
               
                 GSYFIYSKLNMKTSKWEKTDSFSCNVRHEGLKNYYLKKTISRSPGKAS. 
               
               
                   
               
               
                 Anti-DC-SIGNL16E3K (SEQ ID NO: 86): 
               
               
                 ATGGGCATCAAGATGGAGTCACGGATTCAGGCATTTGTATTCGTGTTTCTCTGGTTGTC 
               
               
                   
               
               
                 TGGTGTTGGCGGAGACATTGTGATGACCCAGTCTCACAAATTCATGTCCACATCAGTA 
               
               
                   
               
               
                 GGAGACAGGGTCAGCGTCACCTGCAAGGCCAGTCAGGATGTGACTTCTGCTGTAGCCT 
               
               
                   
               
               
                 GGTATCAACAAAAACCAGGGCAATCTCCTAAACTACTGATTTACTGGGCATCCACCCG 
               
               
                   
               
               
                 GCACACTGGAGTCCCTGATCGCTTCACAGGCAGTGGATCTGGGACAGATTATACTCTC 
               
               
                   
               
               
                 ACCATCAGCAGTGGGCAGGCTGAAGACCTGGCACTTTATTACTGTCACCAATATTATA 
               
               
                   
               
               
                 GCGCTCCTCGGACGTTCGGTGGAGGCACCAAGCTGGAAGTCAAACGGGCTGATGCTGC 
               
               
                   
               
               
                 ACCAACTGTATCCATCTTCCCACCATCCAGTGAGCAGTTAACATCTGGAGGTGCCTCA 
               
               
                   
               
               
                 GTCGTGTGCTTCTTGAACAACTTCTACCCCAAAGACATCAATGTCAAGTGGAAGATTG 
               
               
                   
               
               
                 ATGGCAGTGAACGACAAAATGGCGTCCTGAACAGTTGGACTGATCAGGACAGCAAAG 
               
               
                   
               
               
                 ACAGCACCTACAGCATGAGCAGCACCCTCACGTTGACCAAGGACGAGTATGAACGAC 
               
               
                   
               
               
                 ATAACAGCTATACCTGTGAGGCCACTCACAAGACATCAACTTCACCCATCGTCAAGAG 
               
               
                   
               
               
                 CTTCAATAGGAATGAGTGTTAG 
               
               
                   
               
               
                 Anti-DC-SIGNL16E3K (SEQ ID NO: 87): 
               
               
                 MESRIQAFVFVFLWLSGVGGDIVMTQSHKFMSTSVGDRVSVTCKASQDVTSAVAWYQQK 
               
               
                   
               
               
                 PGQSPKLLIYWASTRHTGVPDRFTGSGSGTDYTLTISSGQAEDLALYYCHQYYSAPRTFGG 
               
               
                   
               
               
                 GTKLEVKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLN 
               
               
                   
               
               
                 SWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC 
               
               
                   
               
               
                 Anti-DC-SIGNL16E7H-LV-hIgG4H-C (SEQ ID NO: 88): 
               
               
                 ATGGAAAGGCACTGGATCTTTCTCTTCCTGTTTTCAGTAACTGCAGGTGTCCACTCCCA 
               
               
                   
               
               
                 GGTCCAGCTTCAGCAGTCTGGGGCTGAGCTGGCAAAACCTGGGGCCTCAGTGAAGATG 
               
               
                   
               
               
                 TCCTGCAAGGCTTCTGGCTACACCTTTACTACCTACTGGATGCACTGGGTAAAACAGA 
               
               
                   
               
               
                 GGCCTGGACAGGGTCTGGAATGGATTGGATACATTAATCCTATCACTGGTTATACTGA 
               
               
                   
               
               
                 GTACAATCAGAAGTTCAAGGACAAGGCCACCTTGACTGCAGACAAATCCTCCAGCAC 
               
               
                   
               
               
                 AGCCTACATGCAACTGAGCAGCCTGACATCTGAGGACTCTGCAGTCTATTACTGTGCA 
               
               
                   
               
               
                 AGAGAGGGTTTAAGTGCTATGGACTATTGGGGTCAGGGAACCTCAGTCACCGTCACCT 
               
               
                   
               
               
                 CAGCCAAAACAACGGGCCCATCCGTCTTCCCCCTGGCGCCCTGCTCCAGGAGCACCTC 
               
               
                   
               
               
                 CGAGAGCACAGCCGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACG 
               
               
                   
               
               
                 GTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTAC 
               
               
                   
               
               
                 AGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGG 
               
               
                   
               
               
                 CACGAAGACCTACACCTGCAACGTAGATCACAAGCCCAGCAACACCAAGGTGGACAA 
               
               
                   
               
               
                 GAGAGTTGAGTCCAAATATGGTCCCCCATGCCCACCCTGCCCAGCACCTGAGTTCGAA 
               
               
                   
               
               
                 GGGGGACCATCAGTCTTCCTGTTCCCCCCAAAACCCAAGGACACTCTCATGATCTCCC 
               
               
                   
               
               
                 GGACCCCTGAGGTCACGTGCGTGGTGGTGGACGTGAGCCAGGAAGACCCCGAGGTCC 
               
               
                   
               
               
                 AGTTCAACTGGTACGTGGATGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGG 
               
               
                   
               
               
                 AGGAGCAGTTCAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGA 
               
               
                   
               
               
                 CTGGCTGAACGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGGCCTCCCGTCCTCC 
               
               
                   
               
               
                 ATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAGCCACAGGTGTACACC 
               
               
                   
               
               
                 CTGCCCCCATCCCAGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCA 
               
               
                   
               
               
                 AAGGCTTCTACCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGA 
               
               
                   
               
               
                 ACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTACAGC 
               
               
                   
               
               
                 AGGCTAACCGTGGACAAGAGCAGGTGGCAGGAGGGGAATGTCTTCTCATGCTCCGTG 
               
               
                   
               
               
                 ATGCATGAGGCTCTGCACAACCACTACACACAGAAGAGCCTCTCCCTGTCTCTGGGTA 
               
               
                   
               
               
                 AAGCTAGCTGA 
               
               
                   
               
               
                 Anti-DC-SIGNL16E7H-LV-hIgG4H-C (SEQ ID NO: 89): 
               
               
                 MERHWIFLFLFSVTAGVHSQVQLQQSGAELAKPGASVKMSCKASGYTFTTYWMHWVKQ 
               
               
                   
               
               
                 RPGQGLEWIGYINPITGYTEYNQKFKDKATLTADKSSSTAYMQLSSLTSEDSAVYYCAREG 
               
               
                   
               
               
                 LSAMDYWGQGTSVTVTSAKTTGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNS 
               
               
                   
               
               
                 GALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGP 
               
               
                   
               
               
                 PCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVH 
               
               
                   
               
               
                 NAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPRE 
               
               
                   
               
               
                 PQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL 
               
               
                   
               
               
                 YSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGKAS. 
               
               
                   
               
               
                 Anti-DC-SIGNL16E7K-LV-hIgGK-C (SEQ ID NO: 90): 
               
               
                 ATGGGCATCAAGATGGAGTCACAGATTCAGGCATTTGTATTCGTGTTTCTCTGGTTGTC 
               
               
                   
               
               
                 TGGTGTTGGCGGAGACATTGTGATGACCCAGTCTCACAAATTCATGTCCACATCAGTA 
               
               
                   
               
               
                 GGAGACAGGGTCAGCGTCACCTGCAAGGCCAGTCAGGATGTGACTTCTGCTGTAGCCT 
               
               
                   
               
               
                 GGTATCAACAAAAACCAGGGCAATCTCCTAAACTACTGATTTACTGGGCATCCACCCG 
               
               
                   
               
               
                 GCACACTGGAGTCCCTGATCGCTTCACAGGCAGTGGATCTGGGACAGATTATACTCTC 
               
               
                   
               
               
                 ACCATCAGCAGTGGGCAGGCTGAAGACCTGGCACTTTATTACTGTCACCAATATTATA 
               
               
                   
               
               
                 GCGCTCCTCGGACGTTCGGTGGAGGCACCAAGCTCGAGATCAAACGAACTGTGGCTGC 
               
               
                   
               
               
                 ACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTG 
               
               
                   
               
               
                 TTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGA 
               
               
                   
               
               
                 TAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGA 
               
               
                   
               
               
                 CAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACA 
               
               
                   
               
               
                 CAAAGTCTATGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGC 
               
               
                   
               
               
                 TTCAACAGGGGAGAGTGTTAG 
               
               
                   
               
               
                 Anti-DC-SIGNL16E7K-LV-hIgGK-C (SEQ ID NO: 91): 
               
               
                 MESQIQAFVFVFLWLSGVGGDIVMTQSHKFMSTSVGDRVSVTCKASQDVTSAVAWYQQK 
               
               
                   
               
               
                 PGQSPKLLIYWASTRHTGVPDRFTGSGSGTDYTLTISSGQAEDLALYYCHQYYSAPRTFGG 
               
               
                   
               
               
                 GTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQE 
               
               
                   
               
               
                 SVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 Anti-Dectin_1_11B6.4_H-V-hIgG4H-C (SEQ ID NO: 92): 
               
               
                 ATGGCTGTCCTGGCACTACTCCTCTGCCTGGTGGCTTTCCCAACTTGTACCCTGTCCCA 
               
               
                   
               
               
                 GGTGCAACTGAAGGAGTCAGGACCTGGCCTGGTGGCGCCCTCACAGAGCCTGTCCATT 
               
               
                   
               
               
                 ACCTGCTCTGTCTCTGGGTTCTCATTAAGCAACTATGATATAAGCTGGATTCGCCAGCC 
               
               
                   
               
               
                 ACCAGGAAAGGGTCTGGAGTGGCTTGGAGTAATGTGGACTGGTGGAGGCGCAAATTA 
               
               
                   
               
               
                 TAATTCAGCTTTCATGTCCAGACTGAGCATCAACAAGGACAACTCCAAGAGCCAAGTT 
               
               
                   
               
               
                 TTTTTAAAAATGAACAATCTGCAAACTGATGACACAGCCATTTATTACTGTGTCAGAG 
               
               
                   
               
               
                 ATGCGGTGAGGTACTGGAACTTCGATGTCTGGGGCGCAGGGACCACGGTCACCGTCTC 
               
               
                   
               
               
                 CTCAGCCAAAACGAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTGCTCCAGGAGCACC 
               
               
                   
               
               
                 TCCGAGAGCACAGCCGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGA 
               
               
                   
               
               
                 CGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCT 
               
               
                   
               
               
                 ACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTG 
               
               
                   
               
               
                 GGCACGAAGACCTACACCTGCAACGTAGATCACAAGCCCAGCAACACCAAGGTGGAC 
               
               
                   
               
               
                 AAGAGAGTTGAGTCCAAATATGGTCCCCCATGCCCACCCTGCCCAGCACCTGAGTTCG 
               
               
                   
               
               
                 AAGGGGGACCATCAGTCTTCCTGTTCCCCCCAAAACCCAAGGACACTCTCATGATCTC 
               
               
                   
               
               
                 CCGGACCCCTGAGGTCACGTGCGTGGTGGTGGACGTGAGCCAGGAAGACCCCGAGGT 
               
               
                   
               
               
                 CCAGTTCAACTGGTACGTGGATGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCG 
               
               
                   
               
               
                 GGAGGAGCAGTTCAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAG 
               
               
                   
               
               
                 GACTGGCTGAACGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGGCCTCCCGTCC 
               
               
                   
               
               
                 TCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAGCCACAGGTGTAC 
               
               
                   
               
               
                 ACCCTGCCCCCATCCCAGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCCTGG 
               
               
                   
               
               
                 TCAAAGGCTTCTACCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGG 
               
               
                   
               
               
                 AGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTA 
               
               
                   
               
               
                 CAGCAGGCTAACCGTGGACAAGAGCAGGTGGCAGGAGGGGAATGTCTTCTCATGCTC 
               
               
                   
               
               
                 CGTGATGCATGAGGCTCTGCACAACCACTACACACAGAAGAGCCTCTCCCTGTCTCTG 
               
               
                   
               
               
                 GGTAAAGCTAGCTGA 
               
               
                   
               
               
                 Anti-Dectin_1_11B6.4_H-V-hIgG4H-C (SEQ ID NO: 93): 
               
               
                 MAVLALLLCLVAFPTCTLSQVQLKESGPGLVAPSQSLSITCSVSGFSLSNYDISWIRQPPGK 
               
               
                   
               
               
                 GLEWLGVMWTGGGANYNSAFMSRLSINKDNSKSQVFLKMNNLQTDDTAIYYCVRDAVR 
               
               
                   
               
               
                 YWNFDVWGAGTTVTVSSAKTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNS 
               
               
                   
               
               
                 GALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGP 
               
               
                   
               
               
                 PCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVH 
               
               
                   
               
               
                 NAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPRE 
               
               
                   
               
               
                 PQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL 
               
               
                   
               
               
                 YSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGKAS 
               
               
                   
               
               
                 Anti-Dectin_1_11B6.4_K-LV-hIgGK-C (SEQ ID NO: 94): 
               
               
                 ATGGATTTTCAAGCGCAGATTTTCAGCTTCCTGCTAATCAGTGCTTCAGTCATAATGTC 
               
               
                   
               
               
                 CAGAGGACAAATTGTTCTCTCCCAGTCACCAGCAATCCTGTCTGCATCTCCAGGGGAG 
               
               
                   
               
               
                 AAGGTCACAATGACTTGCAGGGCCAGCTCAAGTGTAAGTTACATACACTGGTACCAGC 
               
               
                   
               
               
                 AGAAGCCAGGATCCTCCCCCAAACCCTGGATTTATGCCACATCCCACCTGGCTTCTGG 
               
               
                   
               
               
                 AGTCCCTGCTCGCTTCAGTGGCAGTGGGTCTGGGACCTCTTACTCTCTCACAATCAGCA 
               
               
                   
               
               
                 GAGTGGAGGCTGAAGATACTGCCACTTATTACTGCCAGCAGTGGAGTAGTAACCCATT 
               
               
                   
               
               
                 CACGTTCGGCTCGGGGACAAAGCTCGAGATCAAACGAACTGTGGCTGCACCATCTGTC 
               
               
                   
               
               
                 TTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCT 
               
               
                   
               
               
                 GCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTC 
               
               
                   
               
               
                 CAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTAC 
               
               
                   
               
               
                 AGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTAT 
               
               
                   
               
               
                 GCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGG 
               
               
                   
               
               
                 GAGAGTGTTAG 
               
               
                   
               
               
                 Anti-Dectin_1_11B6.4_K-LV-hIgGK-C (SEQ ID NO: 95): 
               
               
                 MDFQAQIFSFLLISASVIMSRGQIVLSQSPAILSASPGEKVTMTCRASSSVSYIHWYQQKPGS 
               
               
                   
               
               
                 SPKPWIYATSHLASGVPARFSGSGSGTSYSLTISRVEAEDTATYYCQQWSSNPFTFGSGTKL 
               
               
                   
               
               
                 EIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTE 
               
               
                   
               
               
                 QDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 Anti-Dectin_1_15E2.5_H-V-hIgG4H-C (SEQ ID NO: 96): 
               
               
                   
               
               
                 ATGGAAAGGCACTGGATCTTTCTACTCCTGTTGTCAGTAACTGCAGGTGTCCACTCCCA 
               
               
                   
               
               
                 GGTCCAGCTGCAGCAGTCTGGGGCTGAACTGGCAAGACCTGGGGCCTCAGTGAAGAT 
               
               
                   
               
               
                 GTCCTGCAAGGCTTCTGGCTACACCTTTACTACCTACACTATGCACTGGGTAAAACAG 
               
               
                   
               
               
                 AGGCCTGGACAGGGTCTGGAATGGATTGGATACATTAATCCTAGCAGTGGTTATACTA 
               
               
                   
               
               
                 ATTACAATCAGAAGTTCAAGGACAAGGCCACATTGACTGCAGACAAATCCTCCAGCAC 
               
               
                   
               
               
                 AGCCTCCATGCAACTGAGCAGCCTGACATCTGAGGACTCTGCAGTCTATTACTGTGCA 
               
               
                   
               
               
                 AGAGAGAGGGCGGTATTAGTCCCCTATGCTATGGACTACTGGGGTCAAGGAACCTCAG 
               
               
                   
               
               
                 TCACCGTCTCCTCAGCCAAAACAAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTGCTCC 
               
               
                   
               
               
                 AGGAGCACCTCCGAGAGCACAGCCGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG 
               
               
                   
               
               
                 AACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCC 
               
               
                   
               
               
                 GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCA 
               
               
                   
               
               
                 GCAGCTTGGGCACGAAGACCTACACCTGCAACGTAGATCACAAGCCCAGCAACACCA 
               
               
                   
               
               
                 AGGTGGACAAGAGAGTTGAGTCCAAATATGGTCCCCCATGCCCACCCTGCCCAGCACC 
               
               
                   
               
               
                 TGAGTTCGAAGGGGGACCATCAGTCTTCCTGTTCCCCCCAAAACCCAAGGACACTCTC 
               
               
                   
               
               
                 ATGATCTCCCGGACCCCTGAGGTCACGTGCGTGGTGGTGGACGTGAGCCAGGAAGACC 
               
               
                   
               
               
                 CCGAGGTCCAGTTCAACTGGTACGTGGATGGCGTGGAGGTGCATAATGCCAAGACAA 
               
               
                   
               
               
                 AGCCGCGGGAGGAGCAGTTCAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCT 
               
               
                   
               
               
                 GCACCAGGACTGGCTGAACGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGGCCT 
               
               
                   
               
               
                 CCCGTCCTCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAGCCACA 
               
               
                   
               
               
                 GGTGTACACCCTGCCCCCATCCCAGGAGGAGATGACCAAGAACCAGGTCAGCCTGAC 
               
               
                   
               
               
                 CTGCCTGGTCAAAGGCTTCTACCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGG 
               
               
                   
               
               
                 CAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCT 
               
               
                   
               
               
                 TCCTCTACAGCAGGCTAACCGTGGACAAGAGCAGGTGGCAGGAGGGGAATGTCTTCTC 
               
               
                   
               
               
                 ATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACACAGAAGAGCCTCTCCCTG 
               
               
                   
               
               
                 TCTCTGGGTAAAGCTAGCTGA 
               
               
                   
               
               
                 Anti-Dectin_1_15E2.5_H-V-hIgG4H-C (SEQ ID NO: 97): 
               
               
                 MERHWIFLLLLSVTAGVHSQVQLQQSGAELARPGASVKMSCKASGYTFTTYTMHWVKQ 
               
               
                   
               
               
                 RPGQGLEWIGYINPSSGYTNYNQKFKDKATLTADKSSSTASMQLSSLTSEDSAVYYCARE 
               
               
                   
               
               
                 RAVLVPYAMDYWGQGTSVTVSSAKTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVT 
               
               
                   
               
               
                 VSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRV 
               
               
                   
               
               
                 ESKYGPPCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYV 
               
               
                   
               
               
                 DGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKA 
               
               
                   
               
               
                 KGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLD 
               
               
                   
               
               
                 SDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGKAS 
               
               
                   
               
               
                 Anti-Dectin_1_15E2.5_K-V-hIgGK-C (SEQ ID NO: 98): 
               
               
                 ATGCATTTTCAAGTGCAGATTTTCAGCTTCCTGCTAATCAGTGCCTCAGTCATAATGTC 
               
               
                   
               
               
                 CAGAGGACAAATTGTTCTCACCCAGTCTCCAGCAGTCATGTCTGCATCTCCAGGGGAG 
               
               
                   
               
               
                 AAGGTCACCATAACCTGCACTGCCAGCTCAAGTTTAAGTTACATGCACTGGTTCCAGC 
               
               
                   
               
               
                 AGAAGCCAGGCACTTCTCCCAAACTCTGGCTTTATAGCACATCCATCCTGGCTTCTGGA 
               
               
                   
               
               
                 GTCCCTACTCGCTTCAGTGGCAGTGGATCTGGGACCTCTTACTCTCTCACAATCAGCCG 
               
               
                   
               
               
                 AATGGAGGCTGAAGATGCTGCCACTTATTACTGCCAGCAAAGGAGTAGTTCCCCATTC 
               
               
                   
               
               
                 ACGTTCGGCTCGGGGACAAAGCTCGAGATCAAACGAACTGTGGCTGCACCATCTGTCT 
               
               
                   
               
               
                 TCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTG 
               
               
                   
               
               
                 CTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCC 
               
               
                   
               
               
                 AATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACA 
               
               
                   
               
               
                 GCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTATG 
               
               
                   
               
               
                 CCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGG 
               
               
                   
               
               
                 AGAGTGTTAG 
               
               
                   
               
               
                 Anti-Dectin_1_15E2.5_K-V-hIgGK-C (SEQ ID NO: 99): 
               
               
                 MHFQVQIFSFLLISASVIMSRGQIVLTQSPAVMSASPGEKVTITCTASSSLSYMHWFQQKPG 
               
               
                   
               
               
                 TSPKLWLYSTSILASGVPTRFSGSGSGTSYSLTISRMEAEDAATYYCQQRSSSPFTFGSGTKL 
               
               
                   
               
               
                 EIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTE 
               
               
                   
               
               
                 QDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 Anti-Dectin_1_2D8.2D4H-V-hIgG4H-C (SEQ ID NO: 100): 
               
               
                 ATGGGATGGACCTGGATCTTTATTTTAATCCTGTCAGTTACTACAGGTGTCCACTCTGA 
               
               
                   
               
               
                 GGTCCAGCTGCAGCAGTCTGGACCTGAGCTGGAGAAGCCTGGCGCTTCAGTGAAGATA 
               
               
                   
               
               
                 TCCTGCAAGGCTTCTGGTTACTCCTTCACTGGCTACAACATGAACTGGGTGAAACAGA 
               
               
                   
               
               
                 GCAATGGAAAGAGCCTTGAGTGGATTGGAAATATTGATCCTTACTATGGTGATACTAA 
               
               
                   
               
               
                 CTACAACCAGAAGTTCAAGGGCAAGGCCACATTGACTGTAGACAAATCCTCCAGCAC 
               
               
                   
               
               
                 AGCCTACATGCACCTCAAGAGCCTGACATCTGAGGACTCTGCAGTCTATTACTGTGCA 
               
               
                   
               
               
                 AGACCCTACGGTAGTGAGGCCTACTTTGCTTACTGGGGCCAAGGGACTCTGGTCACTG 
               
               
                   
               
               
                 TCTCTGCAGCCAAAACGAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTGCTCCAGGAG 
               
               
                   
               
               
                 CACCTCCGAGAGCACAGCCGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCG 
               
               
                   
               
               
                 GTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTG 
               
               
                   
               
               
                 TCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAG 
               
               
                   
               
               
                 CTTGGGCACGAAGACCTACACCTGCAACGTAGATCACAAGCCCAGCAACACCAAGGT 
               
               
                   
               
               
                 GGACAAGAGAGTTGAGTCCAAATATGGTCCCCCATGCCCACCCTGCCCAGCACCTGAG 
               
               
                   
               
               
                 TTCGAAGGGGGACCATCAGTCTTCCTGTTCCCCCCAAAACCCAAGGACACTCTCATGA 
               
               
                   
               
               
                 TCTCCCGGACCCCTGAGGTCACGTGCGTGGTGGTGGACGTGAGCCAGGAAGACCCCGA 
               
               
                   
               
               
                 GGTCCAGTTCAACTGGTACGTGGATGGCGTGGAGGTGCATAATGCCAAGACAAAGCC 
               
               
                   
               
               
                 GCGGGAGGAGCAGTTCAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCAC 
               
               
                   
               
               
                 CAGGACTGGCTGAACGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGGCCTCCCG 
               
               
                   
               
               
                 TCCTCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAGCCACAGGTG 
               
               
                   
               
               
                 TACACCCTGCCCCCATCCCAGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCC 
               
               
                   
               
               
                 TGGTCAAAGGCTTCTACCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGC 
               
               
                   
               
               
                 CGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCT 
               
               
                   
               
               
                 CTACAGCAGGCTAACCGTGGACAAGAGCAGGTGGCAGGAGGGGAATGTCTTCTCATG 
               
               
                   
               
               
                 CTCCGTGATGCATGAGGCTCTGCACAACCACTACACACAGAAGAGCCTCTCCCTGTCT 
               
               
                   
               
               
                 CTGGGTAAAGCTAGCTGA 
               
               
                   
               
               
                 Anti-Dectin_1_2D8.2D4H-V-hIgG4H-C (SEQ ID NO: 101): 
               
               
                 MGWTWIFILILSVTTGVHSEVQLQQSGPELEKPGASVKISCKASGYSFTGYNMNWVKQSN 
               
               
                   
               
               
                 GKSLEWIGNIDPYYGDTNYNQKFKGKATLTVDKSSSTAYMHLKSLTSEDSAVYYCARPY 
               
               
                   
               
               
                 GSEAYFAYWGQGTLVTVSAAKTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSW 
               
               
                   
               
               
                 NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKY 
               
               
                   
               
               
                 GPPCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVE 
               
               
                   
               
               
                 VHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQP 
               
               
                   
               
               
                 REPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSF 
               
               
                   
               
               
                 FLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGKAS 
               
               
                   
               
               
                 Anti-Dectin_1_2D8.2D4K-V-hIgGK-C (SEQ ID NO: 102): 
               
               
                 ATGGTGTCCACTTCTCAGCTCCTTGGACTTTTGCTTTTCTGGACTTCAGCCTCCAGATGT 
               
               
                   
               
               
                 GACATTGTGATGACTCAGTCTCCAGCCACCCTGTCTGTGACTCCAGGAGATAGAGTCT 
               
               
                   
               
               
                 CTCTTTCCTGCAGGGCCAGCCAGAGTATTAGCGACTACTTACACTGGTATCAACAAAA 
               
               
                   
               
               
                 ATCACATGAGTCTCCAAGGCTTCTCATCAAATATGCTGCCCAATCCATCTCTGGGATCC 
               
               
                   
               
               
                 CCTCCAGGTTCAGTGGCAGTGGATCAGGGTCAGATTTCACTCTCAGTATCAACGGTGT 
               
               
                   
               
               
                 GGAACCTGAAGATGTTGGAGTGTATTACTGTCAAAATGGTCACAGCTTTCCGTACACG 
               
               
                   
               
               
                 TTCGGAGGGGGGACCAAGCTCGAGATCAAACGAACTGTGGCTGCACCATCTGTCTTCA 
               
               
                   
               
               
                 TCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGCTG 
               
               
                   
               
               
                 AATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCAAT 
               
               
                   
               
               
                 CGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAGCC 
               
               
                   
               
               
                 TCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTATGCCT 
               
               
                   
               
               
                 GCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGGAG 
               
               
                   
               
               
                 AGTGTTAG 
               
               
                   
               
               
                 Anti-Dectin_1_2D8.2D4K-V-hIgGK-C (SEQ ID NO: 103): 
               
               
                 DIVMTQSPATLSVTPGDRVSLSCRASQSISDYLHWYQQKSHESPRLLIKYAAQSISGIPSRFS 
               
               
                   
               
               
                 GSGSGSDFTLSINGVEPEDVGVYYCQNGHSFPYTFGGGTKLEIKRTVAAPSVFIFPPSDEQL 
               
               
                   
               
               
                 KSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKAD 
               
               
                   
               
               
                 YEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 Anti-Langerin15B10H-LV-hIgG4H-C (SEQ ID NO: 104): 
               
               
                 ATGGAATGGAGGATCTTTCTCTTCATCCTGTCAGGAACTGCAGGTGTCCACTCCCAGGT 
               
               
                   
               
               
                 TCAGCTGCGGCAGTCTGGACCTGAGCTGGTGAAGCCTGGGGCTTCAGTGAAGATGTCC 
               
               
                   
               
               
                 TGCAAGGCTTCTGGATACACATTTACTGACTATGTTATAAGTTGGGTGAAGCAGAGAA 
               
               
                   
               
               
                 CTGGACAGGGCCTTGAGTGGATTGGAGATATTTATCCTGGAAGTGGTTATTCTTTCTAC 
               
               
                   
               
               
                 AATGAGAACTTCAAGGGCAAGGCCACACTGACTGCAGACAAATCCTCCACCACAGCC 
               
               
                   
               
               
                 TACATGCAGCTCAGCAGCCTGACATCTGAGGACTCTGCGGTCTATTTCTGTGCAACCTA 
               
               
                   
               
               
                 CTATAACTACCCTTTTGCTTACTGGGGCCAAGGGACTCTGGTCACTGTCTCTGCAGCCA 
               
               
                   
               
               
                 AAACAACGGGCCCATCCGTCTTCCCCCTGGCGCCCTGCTCCAGGAGCACCTCCGAGAG 
               
               
                   
               
               
                 CACAGCCGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCG 
               
               
                   
               
               
                 TGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCT 
               
               
                   
               
               
                 CAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACGAA 
               
               
                   
               
               
                 GACCTACACCTGCAACGTAGATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGT 
               
               
                   
               
               
                 TGAGTCCAAATATGGTCCCCCATGCCCACCCTGCCCAGCACCTGAGTTCGAAGGGGGA 
               
               
                   
               
               
                 CCATCAGTCTTCCTGTTCCCCCCAAAACCCAAGGACACTCTCATGATCTCCCGGACCCC 
               
               
                   
               
               
                 TGAGGTCACGTGCGTGGTGGTGGACGTGAGCCAGGAAGACCCCGAGGTCCAGTTCAA 
               
               
                   
               
               
                 CTGGTACGTGGATGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCA 
               
               
                   
               
               
                 GTTCAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTG 
               
               
                   
               
               
                 AACGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGGCCTCCCGTCCTCCATCGAG 
               
               
                   
               
               
                 AAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAGCCACAGGTGTACACCCTGCCC 
               
               
                   
               
               
                 CCATCCCAGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGC 
               
               
                   
               
               
                 TTCTACCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAAC 
               
               
                   
               
               
                 TACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTACAGCAGGCT 
               
               
                   
               
               
                 AACCGTGGACAAGAGCAGGTGGCAGGAGGGGAATGTCTTCTCATGCTCCGTGATGCAT 
               
               
                   
               
               
                 GAGGCTCTGCACAACCACTACACACAGAAGAGCCTCTCCCTGTCTCTGGGTAAAGCTA 
               
               
                   
               
               
                 GCTGA 
               
               
                   
               
               
                 Anti-Langerin15B10H-LV-hIgG4H-C (SEQ ID NO: 105): 
               
               
                 QVQLRQSGPELVKPGASVKMSCKASGYTFTDYVISWVKQRTGQGLEWIGDIYPGSGYSFY 
               
               
                   
               
               
                 NENFKGKATLTADKSSTTAYMQLSSLTSEDSAVYFCATYYNYPFAYWGQGTLVTVSAAK 
               
               
                   
               
               
                 TTGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYS 
               
               
                   
               
               
                 LSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPPCPAPEFEGGPSVFLFPPK 
               
               
                   
               
               
                 PKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAKTKPREEQFNSTYRVVSV 
               
               
                   
               
               
                 LTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQVYTLPPSQEEMTKNQVSL 
               
               
                   
               
               
                 TCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSRLTVDKSRWQEGNVFSCS 
               
               
                   
               
               
                 VMHEALHNHYTQKSLSLSLGKAS. 
               
               
                   
               
               
                 Anti-Langerin15B10K-LV-hIgGK-C (SEQ ID NO: 106): 
               
               
                 ATGAAGTTGCCTGTTAGGCTGTTGGTGCTGATGTTCTGGATTCCTGCTTCCAGCAGTGA 
               
               
                   
               
               
                 TGTTGTGATGACCCAAACTCCACTCTCCCTGCCTGTCCGTCTTGGAGATCAAGCCTCCA 
               
               
                   
               
               
                 TCTCTTGCAGATCTAGTCAGAGCCTTGTACACAGTAATGGAAACACCTATTTACATTGG 
               
               
                   
               
               
                 TACCTGCAGAAGCCAGGCCAGTCTCCAAAGCTCCTGATCTACAAAGTTTCCAACCGAT 
               
               
                   
               
               
                 TTTCTGGGGTCCCAGACAGGTTCAGTGGCAGTGGATCAGGGACAAATTTCACACTCAA 
               
               
                   
               
               
                 GATCAGCAGAGTGGAGGCTGAGGATCTGGGACTTTATTTCTGCTCTCAAAGTACACAT 
               
               
                   
               
               
                 GTTCCGTACACGTTCGGAGGGGGGACCAAGCTCGAGATCAAACGAACTGTGGCTGCA 
               
               
                   
               
               
                 CCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGT 
               
               
                   
               
               
                 TGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGAT 
               
               
                   
               
               
                 AACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGAC 
               
               
                   
               
               
                 AGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACAC 
               
               
                   
               
               
                 AAAGTCTATGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCT 
               
               
                   
               
               
                 TCAACAGGGGAGAGTGTTAG 
               
               
                   
               
               
                 Anti-Langerin15B10K-LV-hIgGK-C (SEQ ID NO: 107): 
               
               
                 DVVMTQTPLSLPVRLGDQASISCRSSQSLVHSNGNTYLHWYLQKPGQSPKLLIYKVSNRFS 
               
               
                   
               
               
                 GVPDRFSGSGSGTNFTLKISRVEAEDLGLYFCSQSTHVPYTFGGGTKLEIKRTVAAPSVFIFP 
               
               
                   
               
               
                 PSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTL 
               
               
                   
               
               
                 TLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 Anti-Langerin2G3H-LV-hIgG4H-C (SEQ ID NO: 108): 
               
               
                 ATGACATTGAACATGCTGTTGGGGCTGAGGTGGGTTTTCTTTGTTGTTTTTTATCAAGG 
               
               
                   
               
               
                 TGTGCATTGTGAGGTGCAGCTTGTTGAGTCTGGTGGAGGATTGGTGCAGCCTAAAGGG 
               
               
                   
               
               
                 TCATTGAAACTCTCATGTGCAGCCTCTGGATTAACCTTCAATATCTACGCCATGAACTG 
               
               
                   
               
               
                 GGTCCGCCAGGCTCCAGGAAAGGGTTTGGAATGGGTTGCTCGCATAAGAAATAAAAG 
               
               
                   
               
               
                 TAATAATTATGCAACATATTATGCCGATTCAGTGAAAGACAGGTTCACCATCTCCAGA 
               
               
                   
               
               
                 GATGATTCACAAAGCTTGCTCTATCTGCAAATGAACAACTTGAAAACTGAGGACACAG 
               
               
                   
               
               
                 CCATGTATTACTGTGTGGGACGGGACTGGTTTGATTACTGGGGCCAAGGGACTCTGGT 
               
               
                   
               
               
                 CACTGTCTCTGCAGCCAAAACGAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTGCTCC 
               
               
                   
               
               
                 AGGAGCACCTCCGAGAGCACAGCCGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCG 
               
               
                   
               
               
                 AACCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCC 
               
               
                   
               
               
                 GGCTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCA 
               
               
                   
               
               
                 GCAGCTTGGGCACGAAGACCTACACCTGCAACGTAGATCACAAGCCCAGCAACACCA 
               
               
                   
               
               
                 AGGTGGACAAGAGAGTTGAGTCCAAATATGGTCCCCCATGCCCACCCTGCCCAGCACC 
               
               
                   
               
               
                 TGAGTTCGAAGGGGGACCATCAGTCTTCCTGTTCCCCCCAAAACCCAAGGACACTCTC 
               
               
                   
               
               
                 ATGATCTCCCGGACCCCTGAGGTCACGTGCGTGGTGGTGGACGTGAGCCAGGAAGACC 
               
               
                   
               
               
                 CCGAGGTCCAGTTCAACTGGTACGTGGATGGCGTGGAGGTGCATAATGCCAAGACAA 
               
               
                   
               
               
                 AGCCGCGGGAGGAGCAGTTCAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCT 
               
               
                   
               
               
                 GCACCAGGACTGGCTGAACGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGGCCT 
               
               
                   
               
               
                 CCCGTCCTCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAGCCACA 
               
               
                   
               
               
                 GGTGTACACCCTGCCCCCATCCCAGGAGGAGATGACCAAGAACCAGGTCAGCCTGAC 
               
               
                   
               
               
                 CTGCCTGGTCAAAGGCTTCTACCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGG 
               
               
                   
               
               
                 CAGCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCT 
               
               
                   
               
               
                 TCCTCTACAGCAGGCTAACCGTGGACAAGAGCAGGTGGCAGGAGGGGAATGTCTTCTC 
               
               
                   
               
               
                 ATGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACACAGAAGAGCCTCTCCCTG 
               
               
                   
               
               
                 TCTCTGGGTAAAGCTAGCTGA 
               
               
                   
               
               
                 Anti-Langerin2G3H-LV-hIgG4H-C (SEQ ID NO: 109): 
               
               
                 MTLNMLLGLRWVFFVVFYQGVHCEVQLVESGGGLVQPKGSLKLSCAASGLTFNIYAMN 
               
               
                   
               
               
                 WVRQAPGKGLEWVARIRNKSNNYATYYADSVKDRFTISRDDSQSLLYLQMNNLKTEDTA 
               
               
                   
               
               
                 MYYCVGRDWFDYWGQGTLVTVSAAKTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEP 
               
               
                   
               
               
                 VTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDK 
               
               
                   
               
               
                 RVESKYGPPCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNW 
               
               
                   
               
               
                 YVDGVEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTIS 
               
               
                   
               
               
                 KAKGQPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPV 
               
               
                   
               
               
                 LDSDGSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGKAS. 
               
               
                   
               
               
                 Anti-Langerin2G3L-LV-hIgGK-C (SEQ ID NO: 110): 
               
               
                 ATGGCCTGGATTTCACTTATACTCTCTCTCCTGGCTCTCAGCTCAGGGGCCATTTCCCA 
               
               
                   
               
               
                 GGCTGTTGTGACTCAGGAATCTGCACTCACCACATCACCTGGTGAAACAGTCACACTC 
               
               
                   
               
               
                 ACTTGTCGCTCAAGTACTGGGGCTGTTACAACTAGTAACTATGCCAACTGGGTCCAAG 
               
               
                   
               
               
                 AAAAACCAGATCATTTATTCACTGGTCTAATAGGTGGTACCAACAACCGAGTTTCAGG 
               
               
                   
               
               
                 TGTTCCTGCCAGATTCTCAGGCTCCCTGATTGGAGACAAGGCTGCCCTCACCATCACA 
               
               
                   
               
               
                 GGGGCACAGACTGAGGATGAGGCAATATATTTCTGTGCTCTATGGTACAGCAACCATT 
               
               
                   
               
               
                 GGGTGTTCGGTGGAGGAACCAAACTCGAGATCAAACGAACTGTGGCTGCACCATCTGT 
               
               
                   
               
               
                 CTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCC 
               
               
                   
               
               
                 TGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCT 
               
               
                   
               
               
                 CCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTA 
               
               
                   
               
               
                 CAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTA 
               
               
                   
               
               
                 TGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGG 
               
               
                   
               
               
                 GGAGAGTGTTAG 
               
               
                   
               
               
                 Anti-Langerin2G3L-LV-hIgGK-C (SEQ ID NO: 111): 
               
               
                 MAWISLILSLLALSSGAISQAVVTQESALTTSPGETVTLTCRSSTGAVTTSNYANWVQEKP 
               
               
                   
               
               
                 DHLFTGLIGGTNNRVSGVPARFSGSLIGDKAALTITGAQTEDEAIYFCALWYSNHWVFGG 
               
               
                   
               
               
                 GTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQE 
               
               
                   
               
               
                 SVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 Anti-Lox_1_10F9H-LV-hIgG4H-C (SEQ ID NO: 112): 
               
               
                 ATGGAATGGACCTGGGTCTTTCTCTTCCTCCTGTCAGTAACTGCAGGTGTCCACTCCCA 
               
               
                   
               
               
                 GGTTCAGCTGCAGCAGTCTGGAGCTGAGCTGATGAAGCCTGGGGCCTCAGTGAAGATA 
               
               
                   
               
               
                 TCCTGCAAGGCTACTGGCTACACATTCGGTAGCTACTGGATAGAGTGGGTAAAGCAGA 
               
               
                   
               
               
                 GGCCTGGACATGGCCTTGAGTGGATTGGAGAGATTTTACCTGGAAGTGGTAATACTAA 
               
               
                   
               
               
                 CTACAATGAGAACTTCAAGGGCAAGGCCACATTCACTGCAGATACATCCTCCAACACA 
               
               
                   
               
               
                 GCCTACATGCAACTCACCAGTCTGACATCTGAGGACTCTGCCGTCTATTACTGTGCTAG 
               
               
                   
               
               
                 GGCGGGGATTTATTGGGGCCAAGGGACTCTGGTCACTGTCTCTGCAGCCAAAACGAAG 
               
               
                   
               
               
                 GGCCCATCCGTCTTCCCCCTGGCGCCCTGCTCCAGGAGCACCTCCGAGAGCACAGCCG 
               
               
                   
               
               
                 CCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGTGGAACTC 
               
               
                   
               
               
                 AGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTCAGGACTC 
               
               
                   
               
               
                 TACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACGAAGACCTACA 
               
               
                   
               
               
                 CCTGCAACGTAGATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTTGAGTCCA 
               
               
                   
               
               
                 AATATGGTCCCCCATGCCCACCCTGCCCAGCACCTGAGTTCGAAGGGGGACCATCAGT 
               
               
                   
               
               
                 CTTCCTGTTCCCCCCAAAACCCAAGGACACTCTCATGATCTCCCGGACCCCTGAGGTCA 
               
               
                   
               
               
                 CGTGCGTGGTGGTGGACGTGAGCCAGGAAGACCCCGAGGTCCAGTTCAACTGGTACGT 
               
               
                   
               
               
                 GGATGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAGTTCAACAG 
               
               
                   
               
               
                 CACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGAACGGCAAG 
               
               
                   
               
               
                 GAGTACAAGTGCAAGGTCTCCAACAAAGGCCTCCCGTCCTCCATCGAGAAAACCATCT 
               
               
                   
               
               
                 CCAAAGCCAAAGGGCAGCCCCGAGAGCCACAGGTGTACACCCTGCCCCCATCCCAGG 
               
               
                   
               
               
                 AGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCTTCTACCCCAG 
               
               
                   
               
               
                 CGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACTACAAGACCAC 
               
               
                   
               
               
                 GCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTACAGCAGGCTAACCGTGGACA 
               
               
                   
               
               
                 AGAGCAGGTGGCAGGAGGGGAATGTCTTCTCATGCTCCGTGATGCATGAGGCTCTGCA 
               
               
                   
               
               
                 CAACCACTACACACAGAAGAGCCTCTCCCTGTCTCTGGGTAAAGCTAGCTGA 
               
               
                   
               
               
                 Anti-Lox_1_10F9H-LV-hIgG4H-C (SEQ ID NO: 113): 
               
               
                 MEWTWVFLFLLSVTAGVHSQVQLQQSGAELMKPGASVKISCKATGYTFGSYWIEWVKQ 
               
               
                   
               
               
                 RPGHGLEWIGEILPGSGNTNYNENFKGKATFTADTSSNTAYMQLTSLTSEDSAVYYCARA 
               
               
                   
               
               
                 GIYWGQGTLVTVSAAKTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGALT 
               
               
                   
               
               
                 SGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCPP 
               
               
                   
               
               
                 CPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNAK 
               
               
                   
               
               
                 TKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQV 
               
               
                   
               
               
                 YTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSR 
               
               
                   
               
               
                 LTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGKAS 
               
               
                   
               
               
                 Anti-Lox_1_10F9K-LV-hIgGK-C (SEQ ID NO: 114): 
               
               
                 ATGGAGAAAGACACACTCCTGCTATGGGTCCTGCTTCTCTGGGTTCCAGGTTCCACAG 
               
               
                   
               
               
                 GTGACATTGTGCTGACCCAATCTCCAGCTTTTTTGGCTGTGTCTCTAGGGCAGAGGGCC 
               
               
                   
               
               
                 ACCATCTCCTGCAGAGCCAGCGAAAGTGTTGATAATTATGGCATTAGTTTTATGAACT 
               
               
                   
               
               
                 GGTTCCAACAGAAACCAGGACAGCCACCCAAACTCCTCATCTATGTTGCATCCAAGCA 
               
               
                   
               
               
                 AGGATCCGGGGTCCCTGCCAGGTTTAGTGGCAGTGGGTCTGGGACAGACTTCAGCCTC 
               
               
                   
               
               
                 AACATCCATCCTATGGAGGAGGATGATACTGCAATGTATTTCTGTCAGCAAAGTAAGG 
               
               
                   
               
               
                 AGGTTCCTCGGACGTTCGGTGGAGGCACCAAGCTCGAGATCAAACGAACTGTGGCTGC 
               
               
                   
               
               
                 ACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTG 
               
               
                   
               
               
                 TTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGA 
               
               
                   
               
               
                 TAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGA 
               
               
                   
               
               
                 CAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACA 
               
               
                   
               
               
                 CAAAGTCTATGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGC 
               
               
                   
               
               
                 TTCAACAGGGGAGAGTGTTAG 
               
               
                   
               
               
                 Anti-Lox_1_10F9K-LV-hIgGK-C (SEQ ID NO: 115): 
               
               
                 MEKDTLLLWVLLLWVPGSTGDIVLTQSPAFLAVSLGQRATISCRASESVDNYGISFMNWF 
               
               
                   
               
               
                 QQKPGQPPKLLIYVASKQGSGVPARFSGSGSGTDFSLNIHPMEEDDTAMYFCQQSKEVPRT 
               
               
                   
               
               
                 FGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSG 
               
               
                   
               
               
                 NSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 Anti-LOX-111C8H-LV-hIgG4H-C (SEQ ID NO: 116): 
               
               
                 ATGGAATGTAACTGGATACTTCCTTTTATTCTGTCGGTAACTTCAGGGGTCTACTCAGA 
               
               
                   
               
               
                 GGTTCAGCTCCAGCAGTCTGGGACTGTGCTGGCAAGGCCTGGGGCTTCAGTGAAGATG 
               
               
                   
               
               
                 TCCTGCAAGGCTTCTGGCTACACCTTTACCAGCTACTGGATGCACTGGGTAAAACAGA 
               
               
                   
               
               
                 GGCCTGGACAGGGTCTGGAATGGATTGGCGCTATTTATCCTGGAAATAGTGATACTAC 
               
               
                   
               
               
                 CTACAACCAGAAGTTCAAGGGCAAGGCCAAACTGACTGCAGTCACATCCACCAGCAC 
               
               
                   
               
               
                 TGCCTACATGGAGCTCAGCAGCCTGACAAATGAGGACTCTGCGGTCTATTACTGTACA 
               
               
                   
               
               
                 CCTACTTACTACTTTGACTACTGGGGCCAAGGCACCTCTCTCACAGTCTCCTCAGCCAA 
               
               
                   
               
               
                 AACGAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTGCTCCAGGAGCACCTCCGAGAGC 
               
               
                   
               
               
                 ACAGCCGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGGTGACGGTGTCGT 
               
               
                   
               
               
                 GGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGTCCTACAGTCCTC 
               
               
                   
               
               
                 AGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGCTTGGGCACGAAG 
               
               
                   
               
               
                 ACCTACACCTGCAACGTAGATCACAAGCCCAGCAACACCAAGGTGGACAAGAGAGTT 
               
               
                   
               
               
                 GAGTCCAAATATGGTCCCCCATGCCCACCCTGCCCAGCACCTGAGTTCGAAGGGGGAC 
               
               
                   
               
               
                 CATCAGTCTTCCTGTTCCCCCCAAAACCCAAGGACACTCTCATGATCTCCCGGACCCCT 
               
               
                   
               
               
                 GAGGTCACGTGCGTGGTGGTGGACGTGAGCCAGGAAGACCCCGAGGTCCAGTTCAAC 
               
               
                   
               
               
                 TGGTACGTGGATGGCGTGGAGGTGCATAATGCCAAGACAAAGCCGCGGGAGGAGCAG 
               
               
                   
               
               
                 TTCAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCACCAGGACTGGCTGA 
               
               
                   
               
               
                 ACGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGGCCTCCCGTCCTCCATCGAGA 
               
               
                   
               
               
                 AAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAGCCACAGGTGTACACCCTGCCCC 
               
               
                   
               
               
                 CATCCCAGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCCTGGTCAAAGGCT 
               
               
                   
               
               
                 TCTACCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGCCGGAGAACAACT 
               
               
                   
               
               
                 ACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCTCTACAGCAGGCT 
               
               
                   
               
               
                 AACCGTGGACAAGAGCAGGTGGCAGGAGGGGAATGTCTTCTCATGCTCCGTGATGCAT 
               
               
                   
               
               
                 GAGGCTCTGCACAACCACTACACACAGAAGAGCCTCTCCCTGTCTCTGGGTAAAGCTA 
               
               
                   
               
               
                 GCTGA 
               
               
                   
               
               
                 Anti-LOX-111C8H-LV-hIgG4H-C (SEQ ID NO: 117): 
               
               
                 MECNWILPFILSVTSGVYSEVQLQQSGTVLARPGASVKMSCKASGYTFTSYWMHWVKQR 
               
               
                   
               
               
                 PGQGLEWIGAIYPGNSDTTYNQKFKGKAKLTAVTSTSTAYMELSSLTNEDSAVYYCTPTY 
               
               
                   
               
               
                 YFDYWGQGTSLTVSSAKTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNSGAL 
               
               
                   
               
               
                 TSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGPPCP 
               
               
                   
               
               
                 PCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVHNA 
               
               
                   
               
               
                 KTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPREPQ 
               
               
                   
               
               
                 VYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYS 
               
               
                   
               
               
                 RLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGKAS 
               
               
                   
               
               
                 Anti-LOX-111C8K-LV-hIgGK-C (SEQ ID NO: 118): 
               
               
                 ATGAGTCCTGCCCAATTCCTGTTTCTGTTAGTGCTCTGGATTCGGGAAACCAACGGTGA 
               
               
                   
               
               
                 TGTTGTGATGACCCAGACTCCACTCACTTTGTCGGTTACCATTGGACAACCAGCCTCCA 
               
               
                   
               
               
                 TCTCTTGCAAGTCAAGTCAGAGCCTCTTAGATAGTGATGGAAAGACATATTTGAATTG 
               
               
                   
               
               
                 GTTCTTACAGAGGCCAGGCCAGTCTCCAAAGCGCCTAATCTATCTGGTGTCTAAACTG 
               
               
                   
               
               
                 GACTCTGGAGTCCCTGACAGGTTCACTGGCAGTGGATCAGGGACAGATTTCACACTGA 
               
               
                   
               
               
                 AAATCAGCAGAGTGGAGGCTGAGGATTTGGGAGTTTATTATTGCTGGCAAGGTACACA 
               
               
                   
               
               
                 TTTTCCGTGGACGTTCGGTGGAGGCACCAAGCTCGAGATCAAACGAACTGTGGCTGCA 
               
               
                   
               
               
                 CCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGT 
               
               
                   
               
               
                 TGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGAT 
               
               
                   
               
               
                 AACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGAC 
               
               
                   
               
               
                 AGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACAC 
               
               
                   
               
               
                 AAAGTCTATGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCT 
               
               
                   
               
               
                 TCAACAGGGGAGAGTGTTAG 
               
               
                   
               
               
                 Anti-LOX-111C8K-LV-hIgGK-C (SEQ ID NO: 119): 
               
               
                 MSPAQFLFLLVLWIRETNGDVVMTQTPLTLSVTIGQPASISCKSSQSLLDSDGKTYLNWFL 
               
               
                   
               
               
                 QRPGQSPKRLIYLVSKLDSGVPDRFTGSGSGTDFTLKISRVEAEDLGVYYCWQGTHFPWTF 
               
               
                   
               
               
                 GGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGN 
               
               
                   
               
               
                 SQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 Anti-LOX-115C4H-LV-hIgG4H-C (SEQ ID NO: 120): 
               
               
                 ATGGGAGGGATCTGGATCTTTCTCTTCCTCCTGTCAGGAACTGCAGGTGCCCACTCTGA 
               
               
                   
               
               
                 GATCCAGCTGCAGCAGACTGGACCTGAGCTGGTGAAGCCTGGGGCTTCAGTGAAGAT 
               
               
                   
               
               
                 ATCCTGCAAGGCTTCTGGTTATCCATTCACTGACTACATCATGGTCTGGGTGAAGCAG 
               
               
                   
               
               
                 AGCCATGGAAAGAGCCTTGAGTGGATTGGAAATATTAGTCCTTACTATGGTACTACTA 
               
               
                   
               
               
                 ACTACAATCTGAAGTTCAAGGGCAAGGCCACATTGACTGTAGACAAATCTTCCAGCAC 
               
               
                   
               
               
                 AGCCTACATGCAGCTCAACAGTCTGACATCTGAGGACTCTGCAGTCTATTACTGTGCA 
               
               
                   
               
               
                 AGATCCCCTAACTGGGACGGGGCCTGGTTTGCTCACTGGGGCCAAGGGGCTCTGGTCA 
               
               
                   
               
               
                 CTGTCTCTGCAGCCAAAACAAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTGCTCCAG 
               
               
                   
               
               
                 GAGCACCTCCGAGAGCACAGCCGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAA 
               
               
                   
               
               
                 CCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGG 
               
               
                   
               
               
                 CTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGC 
               
               
                   
               
               
                 AGCTTGGGCACGAAGACCTACACCTGCAACGTAGATCACAAGCCCAGCAACACCAAG 
               
               
                   
               
               
                 GTGGACAAGAGAGTTGAGTCCAAATATGGTCCCCCATGCCCACCCTGCCCAGCACCTG 
               
               
                   
               
               
                 AGTTCGAAGGGGGACCATCAGTCTTCCTGTTCCCCCCAAAACCCAAGGACACTCTCAT 
               
               
                   
               
               
                 GATCTCCCGGACCCCTGAGGTCACGTGCGTGGTGGTGGACGTGAGCCAGGAAGACCCC 
               
               
                   
               
               
                 GAGGTCCAGTTCAACTGGTACGTGGATGGCGTGGAGGTGCATAATGCCAAGACAAAG 
               
               
                   
               
               
                 CCGCGGGAGGAGCAGTTCAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGC 
               
               
                   
               
               
                 ACCAGGACTGGCTGAACGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGGCCTCC 
               
               
                   
               
               
                 CGTCCTCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAGCCACAGG 
               
               
                   
               
               
                 TGTACACCCTGCCCCCATCCCAGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTG 
               
               
                   
               
               
                 CCTGGTCAAAGGCTTCTACCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCA 
               
               
                   
               
               
                 GCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTC 
               
               
                   
               
               
                 CTCTACAGCAGGCTAACCGTGGACAAGAGCAGGTGGCAGGAGGGGAATGTCTTCTCA 
               
               
                   
               
               
                 TGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACACAGAAGAGCCTCTCCCTGT 
               
               
                   
               
               
                 CTCTGGGTAAAGCTAGCTGATTAATTAA 
               
               
                   
               
               
                 Anti-LOX-115C4H-LV-hIgG4H-C (SEQ ID NO: 121): 
               
               
                 MGGIWIFLFLLSGTAGAHSEIQLQQTGPELVKPGASVKISCKASGYPFTDYIMVWVKQSHG 
               
               
                   
               
               
                 KSLEWIGNISPYYGTTNYNLKFKGKATLTVDKSSSTAYMQLNSLTSEDSAVYYCARSPNW 
               
               
                   
               
               
                 DGAWFAHWGQGALVTVSAAKTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSW 
               
               
                   
               
               
                 NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKY 
               
               
                   
               
               
                 GPPCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVE 
               
               
                   
               
               
                 VHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQP 
               
               
                   
               
               
                 REPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSF 
               
               
                   
               
               
                 FLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGKAS 
               
               
                   
               
               
                 Anti-LOX-115C4K-LV-hIgGK-C (SEQ ID NO: 122): 
               
               
                 ATGGAGACAGACACAATCCTGCTATGGGTGCTGCTGCTCTGGGTTCCAGGCTCCACTG 
               
               
                   
               
               
                 GTGACATTGTGCTGACCCAATCTCCAGCTTCTTTGGCTGTGTCTCTAGGGCAGAGGGCC 
               
               
                   
               
               
                 ACCATCTCCTGCAAGGCCAGCCAAAGTGTTGATTATGATGGTGATAGTTATATGAACT 
               
               
                   
               
               
                 GGTTCCAACAGAAACCAGGACAGCCACCCAAACTCCTCATCTATGCTGCATCCAATCT 
               
               
                   
               
               
                 AGAATCTGGGATCCCAGCCAGGTTTAGTGGCAGTGGGTCTGGGACAGACTTCACCCTC 
               
               
                   
               
               
                 AACATCCATCCTGTGGAGGAGGAGGATGCTGCAACCTATTACTGTCAGCAAAGTAATG 
               
               
                   
               
               
                 AGGATCCATTCACGTTCGGCTCGGGGACAAAGCTCGAGATCAAACGAACTGTGGCTGC 
               
               
                   
               
               
                 ACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTG 
               
               
                   
               
               
                 TTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGA 
               
               
                   
               
               
                 TAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGA 
               
               
                   
               
               
                 CAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACA 
               
               
                   
               
               
                 CAAAGTCTATGCCTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGC 
               
               
                   
               
               
                 TTCAACAGGGGAGAGTGTTAG 
               
               
                   
               
               
                 Anti-LOX-115C4K-LV-hIgGK-C (SEQ ID NO: 123): 
               
               
                 METDTILLWVLLLWVPGSTGDIVLTQSPASLAVSLGQRATISCKASQSVDYDGDSYMNWF 
               
               
                   
               
               
                 QQKPGQPPKLLIYAASNLESGIPARFSGSGSGTDFTLNIHPVEEEDAATYYCQQSNEDPFTF 
               
               
                   
               
               
                 GSGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNS 
               
               
                   
               
               
                 QESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 Anti-Marco_10B7.3G4H-LV-hIgG4H-C (SEQ ID NO: 124): 
               
               
                 ATGGCTGTCCTGGGGCTGCTTCTCTGCCTGGTGACGTTCCCAAGCTGTGTCCTGTCCCA 
               
               
                   
               
               
                 GGTGCAGCTGAAGGAGTCAGGACCTGGCCTGGTGGCACCCTCACAGAGCCTGTCCATC 
               
               
                   
               
               
                 ACATGCACTGTCTCTGGGTTCTCATTATCCAGATATAGTGTATTTTGGGTTCGCCAGCC 
               
               
                   
               
               
                 TCCAGGAAAGGGTCTGGAGTGGCTGGGATTGATATGGGGTGGTGGAAGCACAGACTA 
               
               
                   
               
               
                 TAATTCAGCTCTCAAATCCAGACTGAGCATCAGCAAGGACAACTCCAAGAGCCAAGTT 
               
               
                   
               
               
                 TTCTTAAAAATGAACAGTCTGCAAACTGATGACACAGCCATGTACTACTGTGCCAGAA 
               
               
                   
               
               
                 TCTACTTTGATTACGACGGGGCTATGGACTACTGGGGTCAAGGAACCTCAGTCACCGT 
               
               
                   
               
               
                 CTCCTCAGCCAAAACAACGGGCCCATCCGTCTTCCCCCTGGCGCCCTGCTCCAGGAGC 
               
               
                   
               
               
                 ACCTCCGAGAGCACAGCCGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCGG 
               
               
                   
               
               
                 TGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTGT 
               
               
                   
               
               
                 CCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAGC 
               
               
                   
               
               
                 TTGGGCACGAAGACCTACACCTGCAACGTAGATCACAAGCCCAGCAACACCAAGGTG 
               
               
                   
               
               
                 GACAAGAGAGTTGAGTCCAAATATGGTCCCCCATGCCCACCCTGCCCAGCACCTGAGT 
               
               
                   
               
               
                 TCGAAGGGGGACCATCAGTCTTCCTGTTCCCCCCAAAACCCAAGGACACTCTCATGAT 
               
               
                   
               
               
                 CTCCCGGACCCCTGAGGTCACGTGCGTGGTGGTGGACGTGAGCCAGGAAGACCCCGA 
               
               
                   
               
               
                 GGTCCAGTTCAACTGGTACGTGGATGGCGTGGAGGTGCATAATGCCAAGACAAAGCC 
               
               
                   
               
               
                 GCGGGAGGAGCAGTTCAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCAC 
               
               
                   
               
               
                 CAGGACTGGCTGAACGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGGCCTCCCG 
               
               
                   
               
               
                 TCCTCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAGCCACAGGTG 
               
               
                   
               
               
                 TACACCCTGCCCCCATCCCAGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCC 
               
               
                   
               
               
                 TGGTCAAAGGCTTCTACCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGC 
               
               
                   
               
               
                 CGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCT 
               
               
                   
               
               
                 CTACAGCAGGCTAACCGTGGACAAGAGCAGGTGGCAGGAGGGGAATGTCTTCTCATG 
               
               
                   
               
               
                 CTCCGTGATGCATGAGGCTCTGCACAACCACTACACACAGAAGAGCCTCTCCCTGTCT 
               
               
                   
               
               
                 CTGGGTAAAGCTAGCTG 
               
               
                   
               
               
                 Anti-Marco_10B7.3G4H-LV-hIgG4H-C (SEQ ID NO: 125): 
               
               
                 MAVLGLLLCLVTFPSCVLSQVQLKESGPGLVAPSQSLSITCTVSGFSLSRYSVFWVRQPPG 
               
               
                   
               
               
                 KGLEWLGLIWGGGSTDYNSALKSRLSISKDNSKSQVFLKMNSLQTDDTAMYYCARIYFDY 
               
               
                   
               
               
                 DGAMDYWGQGTSVTVSSAKTTGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSWNS 
               
               
                   
               
               
                 GALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKYGP 
               
               
                   
               
               
                 PCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVEVH 
               
               
                   
               
               
                 NAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQPRE 
               
               
                   
               
               
                 PQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFL 
               
               
                   
               
               
                 YSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGKAS 
               
               
                   
               
               
                 AntiMarco_10B7.3G4K_H-V-hIgGK-C (SEQ ID NO: 126): 
               
               
                 ATGCATCGCACCAGCATGGGCATCAAGATGGAGTCACGGATTCAGGCATTTGTATTCG 
               
               
                   
               
               
                 TGTTTCTCTGGTTGTCTGGTGTTGGCGGAGACATTGTGATGACCCAGTCTCACAAATTC 
               
               
                   
               
               
                 ATGTCCACATCAGTAGGAGACAGGGTCAGCGTCACCTGCAAGGCCAGTCAGGATGTG 
               
               
                   
               
               
                 ACTTCTGCTGTAGCCTGGTATCAACAAAAACCAGGGCAATCTCCTAAACTACTGATTT 
               
               
                   
               
               
                 ACTGGGCATCCACCCGGCACACTGGAGTCCCTGATCGCTTCACAGGCAGTGGATCTGG 
               
               
                   
               
               
                 GACAGATTATACTCTCACCATCAGCAGTGGGCAGGCTGAAGACCTGGCACTTTATTAC 
               
               
                   
               
               
                 TGTCACCAATATTATAGCGCTCCTCGGACGTTCGGTGGAGGCACCAAGCTCGAGATCA 
               
               
                   
               
               
                 AACGAACTGTGGCTGCACCATCTGTCTTCATCTTCCCGCCATCTGATGAGCAGTTGAAA 
               
               
                   
               
               
                 TCTGGAACTGCCTCTGTTGTGTGCCTGCTGAATAACTTCTATCCCAGAGAGGCCAAAGT 
               
               
                   
               
               
                 ACAGTGGAAGGTGGATAACGCCCTCCAATCGGGTAACTCCCAGGAGAGTGTCACAGA 
               
               
                   
               
               
                 GCAGGACAGCAAGGACAGCACCTACAGCCTCAGCAGCACCCTGACGCTGAGCAAAGC 
               
               
                   
               
               
                 AGACTACGAGAAACACAAAGTCTATGCCTGCGAAGTCACCCATCAGGGCCTGAGCTC 
               
               
                   
               
               
                 GCCCGTCACAAAGAGCTTCAACAGGGGAGAGTGTTAG 
               
               
                   
               
               
                 AntiMarco_10B7.3G4K_H-V-hIgGK-C (SEQ ID NO: 127): 
               
               
                 MHRTSMGIKMESRIQAFVFVFLWLSGVGGDIVMTQSHKFMSTSVGDRVSVTCKASQDVT 
               
               
                   
               
               
                 SAVAWYQQKPGQSPKLLIYWASTRHTGVPDRFTGSGSGTDYTLTISSGQAEDLALYYCHQ 
               
               
                   
               
               
                 YYSAPRTFGGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVD 
               
               
                   
               
               
                 NALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNR 
               
               
                   
               
               
                 GEC 
               
               
                   
               
               
                 Anti-Marco_11A8.3C9_H-V-hIgG4H-C (SEQ ID NO: 128): 
               
               
                 ATGGAATGGAACTGGGTCGTTCTCTTCCTCCTGTCATTAACTGCAGGTGTCTATGCCCA 
               
               
                   
               
               
                 GGGTCAGATGCAGCAGTCTGGAGCTGAGCTGGTGAAGCCTGGGGCTTCAGTGAAGCT 
               
               
                   
               
               
                 GTCCTGCAAGACTTCTGGCTTCACCTTCAGCAGTAACTATATAAGTTGGTTGAAGCAA 
               
               
                   
               
               
                 AAGCCTGGACAGAGTCTTGAGTGGATTGCATGGATTTATGCTGGAACTGGTGGTATTA 
               
               
                   
               
               
                 CCTATAATCAGAAGTTCAGAGGCAGGGCCCAACTGACTGTAGACACATCCTCCAGCAC 
               
               
                   
               
               
                 AGCCTACATGCAGTTCAGCAGCCTGACAACTGATGACTCTGCCATCTATTACTGTGCA 
               
               
                   
               
               
                 AGACACGTGAGGGGTTACCATCCTATGGACTACTGGGGTCAAGGAACCTCAGTCACCG 
               
               
                   
               
               
                 TCTCCTCAGCCAAAACGAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTGCTCCAGGAG 
               
               
                   
               
               
                 CACCTCCGAGAGCACAGCCGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAACCG 
               
               
                   
               
               
                 GTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGGCTG 
               
               
                   
               
               
                 TCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGCAG 
               
               
                   
               
               
                 CTTGGGCACGAAGACCTACACCTGCAACGTAGATCACAAGCCCAGCAACACCAAGGT 
               
               
                   
               
               
                 GGACAAGAGAGTTGAGTCCAAATATGGTCCCCCATGCCCACCCTGCCCAGCACCTGAG 
               
               
                   
               
               
                 TTCGAAGGGGGACCATCAGTCTTCCTGTTCCCCCCAAAACCCAAGGACACTCTCATGA 
               
               
                   
               
               
                 TCTCCCGGACCCCTGAGGTCACGTGCGTGGTGGTGGACGTGAGCCAGGAAGACCCCGA 
               
               
                   
               
               
                 GGTCCAGTTCAACTGGTACGTGGATGGCGTGGAGGTGCATAATGCCAAGACAAAGCC 
               
               
                   
               
               
                 GCGGGAGGAGCAGTTCAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGCAC 
               
               
                   
               
               
                 CAGGACTGGCTGAACGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGGCCTCCCG 
               
               
                   
               
               
                 TCCTCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAGCCACAGGTG 
               
               
                   
               
               
                 TACACCCTGCCCCCATCCCAGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTGCC 
               
               
                   
               
               
                 TGGTCAAAGGCTTCTACCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCAGC 
               
               
                   
               
               
                 CGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTCCT 
               
               
                   
               
               
                 CTACAGCAGGCTAACCGTGGACAAGAGCAGGTGGCAGGAGGGGAATGTCTTCTCATG 
               
               
                   
               
               
                 CTCCGTGATGCATGAGGCTCTGCACAACCACTACACACAGAAGAGCCTCTCCCTGTCT 
               
               
                   
               
               
                 CTGGGTAAAGCTAGCTGA 
               
               
                   
               
               
                 Anti-Marco_11A8.3C9_H-V-hIgG4H-C (SEQ ID NO: 129): 
               
               
                 MEWNWVVLFLLSLTAGVYAQGQMQQSGAELVKPGASVKLSCKTSGFTFSSNYISWLKQK 
               
               
                   
               
               
                 PGQSLEWIAWIYAGTGGITYNQKFRGRAQLTVDTSSSTAYMQFSSLTTDDSAIYYCARHV 
               
               
                   
               
               
                 RGYHPMDYWGQGTSVTVSSAKTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVSW 
               
               
                   
               
               
                 NSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVESKY 
               
               
                   
               
               
                 GPPCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDGVE 
               
               
                   
               
               
                 VHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKGQP 
               
               
                   
               
               
                 REPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSF 
               
               
                   
               
               
                 FLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGKAS 
               
               
                   
               
               
                 Anti-Marco_11A8.3C9_H-V-hIgGK-C (SEQ ID NO: 130): 
               
               
                 ATGGAGTCACAGACTCAGGTCTTTGTATACATGTTGCTGTGGTTGTCTGGTGTTGATGG 
               
               
                   
               
               
                 AGACATTGTGATGACCCAGTCTCAAAAATTCATGTCCGCATCAGTAGGGGACAGGGTC 
               
               
                   
               
               
                 AGCGTCACCTGCAGGGCCAGTCAGAATGTGGTTACTAATGTAGGCTGGTATCAACAGA 
               
               
                   
               
               
                 AACCAGGGCAATCTCCTAAAGTACTGATTTACTCGGCATCCTTCCGGTACAGTGGAGT 
               
               
                   
               
               
                 CCCTGATCGCTTCACAGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCACCAAT 
               
               
                   
               
               
                 GTGCAGTCTGAAGACTTGGCAGAGTATTTCTGTCAGCAATATAACAACTATCCGTACA 
               
               
                   
               
               
                 CGTTCGGAGGGGGGACCAAGCTCGAGATCAAACGAACTGTGGCTGCACCATCTGTCTT 
               
               
                   
               
               
                 CATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGC 
               
               
                   
               
               
                 TGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCA 
               
               
                   
               
               
                 ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAG 
               
               
                   
               
               
                 CCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTATGC 
               
               
                   
               
               
                 CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGG 
               
               
                   
               
               
                 AGAGTGTTAG 
               
               
                   
               
               
                 Anti-Marco_11A8.3C9_H-V-hIgGK-C (SEQ ID NO: 131): 
               
               
                 MESQTQVFVYMLLWLSGVDGDIVMTQSQKFMSASVGDRVSVTCRASQNVVTNVGWYQ 
               
               
                   
               
               
                 QKPGQSPKVLIYSASFRYSGVPDRFTGSGSGTDFTLTITNVQSEDLAEYFCQQYNNYPYTF 
               
               
                   
               
               
                 GGGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGN 
               
               
                   
               
               
                 SQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
               
                   
               
               
                 Anti-Marco_3H10.1F3_H-V-hIgG4H-C (SEQ ID NO: 132): 
               
               
                 ATGGGATGGAGCTATATCATCCTCTTTTTGGTAGCAACAGCTACAGATGTCCACTCCCA 
               
               
                   
               
               
                 GGTCCAACTGCAGCAGCCTGGGGCTGAACTGGTGAAGCCTGGGGCTTCAGTGAAGCTG 
               
               
                   
               
               
                 TCCTGCAAGGCTTCTGGCTACACCTTCACCAGCTACTGGATGCACTGGGTGAAGCAGA 
               
               
                   
               
               
                 GGCCTGGAGAAGGCCTTGAGTGGATTGGAGAGATTAATCCTAGCTACGGTCGTACTGA 
               
               
                   
               
               
                 CTACAATGGGAAGTTCAAGAACAAGGCCACACTGACTGTAGCCAAATCCTCCAGCAC 
               
               
                   
               
               
                 AGCCTACATGCAACTCAGCAGCCTGACATCTGAGGACTCTGCGGTCTATTACTGTGCA 
               
               
                   
               
               
                 AGAGGAGATTACTACGGTAGTAGCTCGTTTGCTTACTGGGGCCAAGGGACTCTGGTCA 
               
               
                   
               
               
                 CTGTCTCTGCAGCCAAAACAAAGGGCCCATCCGTCTTCCCCCTGGCGCCCTGCTCCAG 
               
               
                   
               
               
                 GAGCACCTCCGAGAGCACAGCCGCCCTGGGCTGCCTGGTCAAGGACTACTTCCCCGAA 
               
               
                   
               
               
                 CCGGTGACGGTGTCGTGGAACTCAGGCGCCCTGACCAGCGGCGTGCACACCTTCCCGG 
               
               
                   
               
               
                 CTGTCCTACAGTCCTCAGGACTCTACTCCCTCAGCAGCGTGGTGACCGTGCCCTCCAGC 
               
               
                   
               
               
                 AGCTTGGGCACGAAGACCTACACCTGCAACGTAGATCACAAGCCCAGCAACACCAAG 
               
               
                   
               
               
                 GTGGACAAGAGAGTTGAGTCCAAATATGGTCCCCCATGCCCACCCTGCCCAGCACCTG 
               
               
                   
               
               
                 AGTTCGAAGGGGGACCATCAGTCTTCCTGTTCCCCCCAAAACCCAAGGACACTCTCAT 
               
               
                   
               
               
                 GATCTCCCGGACCCCTGAGGTCACGTGCGTGGTGGTGGACGTGAGCCAGGAAGACCCC 
               
               
                   
               
               
                 GAGGTCCAGTTCAACTGGTACGTGGATGGCGTGGAGGTGCATAATGCCAAGACAAAG 
               
               
                   
               
               
                 CCGCGGGAGGAGCAGTTCAACAGCACGTACCGTGTGGTCAGCGTCCTCACCGTCCTGC 
               
               
                   
               
               
                 ACCAGGACTGGCTGAACGGCAAGGAGTACAAGTGCAAGGTCTCCAACAAAGGCCTCC 
               
               
                   
               
               
                 CGTCCTCCATCGAGAAAACCATCTCCAAAGCCAAAGGGCAGCCCCGAGAGCCACAGG 
               
               
                   
               
               
                 TGTACACCCTGCCCCCATCCCAGGAGGAGATGACCAAGAACCAGGTCAGCCTGACCTG 
               
               
                   
               
               
                 CCTGGTCAAAGGCTTCTACCCCAGCGACATCGCCGTGGAGTGGGAGAGCAATGGGCA 
               
               
                   
               
               
                 GCCGGAGAACAACTACAAGACCACGCCTCCCGTGCTGGACTCCGACGGCTCCTTCTTC 
               
               
                   
               
               
                 CTCTACAGCAGGCTAACCGTGGACAAGAGCAGGTGGCAGGAGGGGAATGTCTTCTCA 
               
               
                   
               
               
                 TGCTCCGTGATGCATGAGGCTCTGCACAACCACTACACACAGAAGAGCCTCTCCCTGT 
               
               
                   
               
               
                 CTCTGGGTAAAGCTAGCTGA 
               
               
                   
               
               
                 Anti-Marco_3H10.1F3_H-V-hIgG4H-C (SEQ ID NO: 133): 
               
               
                 MGWSYIILFLVATATDVHSQVQLQQPGAELVKPGASVKLSCKASGYTFTSYWMHWVKQ 
               
               
                   
               
               
                 RPGEGLEWIGEINPSYGRTDYNGKFKNKATLTVAKSSSTAYMQLSSLTSEDSAVYYCARG 
               
               
                   
               
               
                 DYYGSSSFAYWGQGTLVTVSAAKTKGPSVFPLAPCSRSTSESTAALGCLVKDYFPEPVTVS 
               
               
                   
               
               
                 WNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTKTYTCNVDHKPSNTKVDKRVES 
               
               
                   
               
               
                 KYGPPCPPCPAPEFEGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSQEDPEVQFNWYVDG 
               
               
                   
               
               
                 VEVHNAKTKPREEQFNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKGLPSSIEKTISKAKG 
               
               
                   
               
               
                 QPREPQVYTLPPSQEEMTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSD 
               
               
                   
               
               
                 GSFFLYSRLTVDKSRWQEGNVFSCSVMHEALHNHYTQKSLSLSLGKAS 
               
               
                   
               
               
                 Anti-Marco_3H10.1F3_K-V-hIgGK-C (SEQ ID NO: 134): 
               
               
                 ATGGAGTCACAGACTCAGGTCTTTGTATACATGTTGCTGTGGTTGTCTGGTGTTGATGG 
               
               
                   
               
               
                 AGACATTGTGATGACCCAGTCTCAAAAATTCATGTCCACATCATTAGGAGACAGGGTC 
               
               
                   
               
               
                 AGCGTCACCTGCAAGGCCAGTCAGAATGTGGGTACTAATGTAGCCTGGTATCAACAGA 
               
               
                   
               
               
                 AACCAGGGCACTCTCCTAAAGCACTGATTTACTCGGCATCCTACCGGTACAGTGGAGT 
               
               
                   
               
               
                 CCCTGATCGCTTCACAGGCAGTGGATCTGGGACAGATTTCACTCTCACCATCAGCAAT 
               
               
                   
               
               
                 GTGCAGTCTGAAGACTTGGCAGAGTTTTTCTGTCAGCAATATAACAACTATCCGTACA 
               
               
                   
               
               
                 CGTTCGGAGGGGGGACCACGCTCGAGATCAAACGAACTGTGGCTGCACCATCTGTCTT 
               
               
                   
               
               
                 CATCTTCCCGCCATCTGATGAGCAGTTGAAATCTGGAACTGCCTCTGTTGTGTGCCTGC 
               
               
                   
               
               
                 TGAATAACTTCTATCCCAGAGAGGCCAAAGTACAGTGGAAGGTGGATAACGCCCTCCA 
               
               
                   
               
               
                 ATCGGGTAACTCCCAGGAGAGTGTCACAGAGCAGGACAGCAAGGACAGCACCTACAG 
               
               
                   
               
               
                 CCTCAGCAGCACCCTGACGCTGAGCAAAGCAGACTACGAGAAACACAAAGTCTATGC 
               
               
                   
               
               
                 CTGCGAAGTCACCCATCAGGGCCTGAGCTCGCCCGTCACAAAGAGCTTCAACAGGGG 
               
               
                   
               
               
                 AGAGTGTTAG 
               
               
                   
               
               
                 Anti-Marco_3H10.1F3_K-V-hIgGK-C (SEQ ID NO: 135): 
               
               
                 MESQTQVFVYMLLWLSGVDGDIVMTQSQKFMSTSLGDRVSVTCKASQNVGTNVAWYQQ 
               
               
                   
               
               
                 KPGHSPKALIYSASYRYSGVPDRFTGSGSGTDFTLTISNVQSEDLAEFFCQQYNNYPYTFGG 
               
               
                   
               
               
                 GTTLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQE 
               
               
                   
               
               
                 SVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC 
               
             
          
         
       
     
         [0065]    The antigens of the present invention comprises one or more viral antigens or peptides from adenovirus, retrovirus, picornavirus, herpesvirus, rotaviruses, hantaviruses, coronavirus, togavirus, flavirvirus, rhabdovirus, paramyxovirus, orthomyxovirus, bunyavirus, arenavirus, reovirus, papilomavirus, parvovirus, poxvirus, hepadnavirus, or spongiform virus, HIV, CMV, hepatitis A, B, and C, influenza; measles, polio, smallpox, rubella; respiratory syncytial, herpes simplex, varicella zoster, Epstein-Barr, Japanese encephalitis, rabies, flu, or cold viruses. The antigen is selected from: Nef (66-97): VGFPVTPQVPLRPMTYKAAVDLSHFLKEKGGL (SEQ ID NO: 136); Nef (116-145): HTQGYFPDWQNYTPGPGVRYPLTFGWLYKL (SEQ ID NO: 137); Gag p17 (17-35): EKIRLRPGGKKKYKLKHIV (SEQ ID NO: 138); Gag p17-p24 (253-284): NPPIPVGEIYKRWIILGLNKIVRMYSPTSILD (SEQ ID NO: 139); and/or Pol 325-355 (RT 158-188) is: AIFQSSMTKILEPFRKQNPDIVIYQYMDDLY (SEQ ID NO: 140). In one aspect the said antigen is 19 to 32 residues and is selected from a cytotoxic T lymphocyte (CTL) epitope identified in the HIV-1 Nef, Gag and Env proteins presented in the context of MHC-class I molecules. In another aspect, the Ag is selected from HIV gp120, gp41, Gag, p17, p24, p2, p′7, p1, p6, Tat, Rev, PR, RT, IN, Vif, Vpr, Vpx, Vpu and Nef. 
         [0066]    In another aspect the antigen is selected from tumor associated antigens selected from CEA, prostate specific antigen (PSA), HER-2/neu, BAGE, GAGE, MAGE 1-4, 6 and 12, MUC-related protein (Mucin) (MUC-1, MUC-2, etc.), GM2 and GD2 gangliosides, ras, myc, tyrosinase, MART (melanoma antigen), MARCO-MART, cyclin B1, cyclin D, Pmel 17(gp100), GnT-V intron V sequence (N-acetylglucoaminyltransferase V intron V sequence), Prostate Ca psm, prostate serum antigen (PSA), PRAME (melanoma antigen), β-catenin, MUM-1-B (melanoma ubiquitous mutated gene product), GAGE (melanoma antigen) 1, BAGE (melanoma antigen) 2-10, c-ERB2 (Her2/neu), EBNA (Epstein-Barr Virus nuclear antigen) 1-6, gp75, human papilloma virus (HPV) E6 and E7, p53, lung resistance protein (LRP), Bcl-2, and Ki-67. In another aspect, the Ag is selected from tumor associated antigens comprising antigens from leukemias and lymphomas, neurological tumors such as astrocytomas or glioblastomas, melanoma, breast cancer, lung cancer, head and neck cancer, gastrointestinal tumors, gastric cancer, colon cancer, liver cancer, pancreatic cancer, genitourinary tumors such cervix, uterus, ovarian cancer, vaginal cancer, testicular cancer, prostate cancer or penile cancer, bone tumors, vascular tumors, or cancers of the lip, nasopharynx, pharynx and oral cavity, esophagus, rectum, gall bladder, biliary tree, larynx, lung and bronchus, bladder, kidney, brain and other parts of the nervous system, thyroid, Hodgkin&#39;s disease, non-Hodgkin&#39;s lymphoma, multiple myeloma and leukemia. 
         [0067]    The Ag is selected from at least one of: 
         [0000]    
       
         
               
             
               
             
               
             
               
             
               
             
               
             
               
             
               
             
               
             
               
             
           
               
                 (SEQ ID NO: 141) 
               
             
          
           
               
                 MWVPVVFLTLSVTWIGAAPLILSRIVGGWECEKHSQPWQVLVASRGRAV 
               
               
                   
               
               
                 CGGVLVHPQWV; 
               
               
                   
               
             
          
           
               
                 (SEQ ID NO: 142) 
               
             
          
           
               
                 LTAAHCIRNKSVILLGRHSLFHPEDTGQVFQVSHSFPHPLYDMSLLKNR 
               
               
                   
               
               
                 FLRPGDDSSHD; 
               
               
                   
               
             
          
           
               
                 (SEQ ID NO: 143) 
               
             
          
           
               
                 LMLLRLSEPAELTDAVKVMDLPTQEPALGTTCYASGWGSIEPEEFLTPK 
               
               
                   
               
               
                 KLQCVDLHVIS; 
               
               
                   
               
             
          
           
               
                 (SEQ ID NO: 144) 
               
             
          
           
               
                 NDVCAQVHPQKVTKFMLCAGRWTGGKSTCSGDSGGPLVCNGVLQGITS 
               
               
                   
               
               
                 WGSEPCALPERP; 
               
               
                 or 
               
               
                   
               
             
          
           
               
                 (SEQ ID NO: 145) 
               
             
          
           
               
                 SLYTKVVHYRKWIKDTIVANP. 
               
             
          
         
       
     
         [0068]    In another aspect, the Ag is selected from at least one of: 
         [0000]    
       
         
               
             
               
             
               
             
               
             
               
             
               
             
               
             
               
             
               
             
               
             
               
             
               
             
               
             
               
             
               
             
               
             
               
             
               
             
               
             
               
             
           
               
                 (SEQ ID NO: 146) 
               
             
          
           
               
                 IMDQVPFSV; 
               
               
                   
               
             
          
           
               
                 (SEQ ID NO: 147) 
               
             
          
           
               
                 ITDQVPFSV; 
               
               
                   
               
             
          
           
               
                 (SEQ ID NO: 148) 
               
             
          
           
               
                 YLEPGPVTV; 
               
               
                   
               
             
          
           
               
                 (SEQ ID NO: 149) 
               
             
          
           
               
                 YLEPGPVTA; 
               
               
                   
               
             
          
           
               
                 (SEQ ID NO: 150) 
               
             
          
           
               
                 KTWGQYWQV; 
               
               
                   
               
             
          
           
               
                 (SEQ ID NO: 151) 
               
             
          
           
               
                 DTTEPATPTTPVTTPTTTKVPRNQDWLGVSRQLRTKAWNRQLYPEWTEA 
               
               
                   
               
               
                 QRLDCWRGGQVSLKVSNDGPTLIGANASFSIALNFPGSQKVLPDGQVIW 
               
               
                   
               
               
                 VNNTIINGSQVWGGQPVYPQETDDACIFPDGGPCPSGSWSQKRSFVYVW 
               
               
                   
               
               
                 KTWGQYWQVLGGPVSGLSIGTGRAMLGTHTMEVTVYHRRGSQSYVPLAH 
               
               
                   
               
               
                 SSSAFTITDQVPFSVSVSQLRALDGGNKHFLRNQ; 
               
               
                   
               
             
          
           
               
                 (SEQ ID NO: 152) 
               
             
          
           
               
                 PLTFALQLHDPSGYLAEADLSYTWDFGDSSGTLISRAXVVTHTYLEPGPV 
               
               
                   
               
               
                 TAQVVLQAAIPLTSCGSSPVPAS; 
               
               
                   
               
             
          
           
               
                 (SEQ ID NO: 153) 
               
             
          
           
               
                 GTTDGHRPTAEAPNTTAGQVPTTEVVGTTPGQAPTAEPSGTTSVQVPTT 
               
               
                   
               
               
                 EVISTAPVQMPTAESTGMTPEKVPVSEVMGTTLAEMSTPEATGMTPAEV 
               
               
                   
               
               
                 SIVVLSGTTAA; 
               
               
                   
               
             
          
           
               
                 (SEQ ID NO: 154) 
               
             
          
           
               
                 QVTTTEWVETTARELPIPEPEGPDASSIMSTESITGSLGPLLDGTATLRL 
               
               
                   
               
               
                 VKRQVPLDCVLYRYGSFSVTLDIVQ; 
               
               
                 and 
               
               
                   
               
             
          
           
               
                 (SEQ ID NO: 155) 
               
             
          
           
               
                 GIESAEILQAVPSGEGDAFELTVSCQGGLPKEACMEISSPGCQPPAQRLC 
               
               
                   
               
               
                 QPVLPSPACQLVLHQILKGGSGTYCLNVSLADTNSLAVVSTQLIVPGILL 
               
               
                   
               
               
                 TGQEAGLGQ, 
               
               
                 and fragments thereof. 
               
             
          
         
       
     
         [0069]    In yet another aspect, the Ag is selected from at least one of: 
         [0000]    
       
         
               
             
               
             
               
             
               
             
           
               
                 (SEQ ID NO: 156) 
               
             
          
           
               
                 MEMKILRALNFGLGRPLPLHFLRRASKIGEVDVEQHTLAKYLMELTML 
               
               
                   
               
               
                 DY; 
               
               
                 and 
               
               
                   
               
             
          
           
               
                 (SEQ ID NO: 157) 
               
             
          
           
               
                 DWLVQVQMKFRLLQETMYMTVSIIDRFMQNNCVPKK. 
               
             
          
         
       
     
         [0070]    In another aspect, the Ag is selected from at least one of: 
         [0000]    
       
         
               
             
               
             
               
             
               
             
               
             
               
             
               
             
               
             
           
               
                 (SEQ ID NO: 158) 
               
             
          
           
               
                 MEHQLLCCEVETIRRAYPDANLLNDRVLRAMLKAEETCAPSVSYFKCV; 
               
               
                   
               
             
          
           
               
                 (SEQ ID NO: 159) 
               
             
          
           
               
                 QKEVLPSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSLEPVKK 
               
               
                   
               
               
                 SRLQLLGATCMFVASKMKETIPLTAEKLCIYTDNSIRPEELLQMELL; 
               
               
                   
               
             
          
           
               
                 (SEQ ID NO: 160) 
               
             
          
           
               
                 LVNKLKWNLAAMTPHDFIEHFLSKMPEAEENKQIIRKHAQTFVALCATDV 
               
               
                   
               
               
                 KFISNPPSMV; 
               
               
                 and 
               
               
                   
               
             
          
           
               
                 (SEQ ID NO: 161) 
               
             
          
           
               
                 AGSVVAAVQGLNLRSPNNFLSYYRLTRFLSRVIKCDPDCLRACQEQIEA 
               
               
                   
               
               
                 LLESSLRQAQQNMDPKAAEEEEEEEEEVDLACTPTDVRDVDI, 
               
               
                 and fragments thereof. 
               
             
          
         
       
     
         [0071]    In another aspect, the Ag is 19 to 32 amino acids long. In another aspect, the Ag is 17 to 60 amino acids long and is selected from a cytotoxic T lymphocyte (CTL) epitope identified in PSA or cyclin 1 
         [0072]    In another aspect, the cancer peptides are selected from tumor associated antigens selected from CEA, prostate specific antigen (PSA), HER-2/neu, BAGE, GAGE, MAGE 1-4, 6 and 12, MUC-related protein (Mucin) (MUC-1, MUC-2, etc.), GM2 and GD2 gangliosides, ras, myc, tyrosinase, MART (melanoma antigen), MARCO-MART, cyclin B1, cyclin D, Pmel 17(gp100), GnT-V intron V sequence (N-acetylglucoaminyltransferase V intron V sequence), Prostate Ca psm, prostate serum antigen (PSA), PRAME (melanoma antigen), β-catenin, MUM-1-B (melanoma ubiquitous mutated gene product), GAGE (melanoma antigen) 1, BAGE (melanoma antigen) 2-10, c-ERB2 (Her2/neu), EBNA (Epstein-Barr Virus nuclear antigen) 1-6, gp75, human papilloma virus (HPV) E6 and E7, p53, lung resistance protein (LRP), Bcl-2, and Ki-67. 
         [0073]    Preparation of Cells: Apheresis Procedures were Performed on Healthy Individuals after informed consent was collected. This protocol was reviewed and approved by the Baylor Research Institute Institutional Review Board. PBMCs were purified from apheresis blood samples and used after cryopreservation. Monocyte-derived IFNa-DCs were prepared from frozen human monocytes (elutriation fraction 5, Lemarie et al, J. Immunological Methods, 2007) cultured with GM-CSF (100 ng/ml) and IFNa (500 U/ml)) (Salluto et al, J. Exp. Med) for 3 days in Cellgenix. 
         [0074]    Extracellular cytokine secretion assay. PBMCs or monocyte-derived IFNa-DCs (2×10 6  cells/ml, 200 μl/well) were cultured in cRPMI containing 10% human AB serum, 2 mM L-glutamine, 50 U penicillin, 50 μg/ml streptomycin, 1× essential amino acids, 25 mM hepes, 55 μLLM 2-mercapto-ethanol with DC-targeting vaccines and TLR ligands of interest or left unstimulated (negative control) for 24 h, at 37° C. and 5% CO2. Then culture supernatants were harvested and then the secreted cytokines were measured in the culture supernatants using BioPlex200 Luminex (BioRad). 
         [0075]      FIGS. 1A to 1D  shows flagellin and the several antibody-flagellin contructs of the present invention. 
         [0076]      FIG. 2  shows the design of the studies used to test the activity of the antibody-flagellin constructs of the present invention. 
         [0077]      FIGS. 3A to 3C  show the secretion of IL-6 when various types of cells were activated with the construction of the present invention. The addition of the flexible linker (flex) between the 2 flagellin domains (flgn1 and flgn2) abolishes the activity. The various cells were IFNalpha activated DCs and Peripheral Blood Mononuclear Cells (PBMCs). 
         [0078]      FIGS. 4A to 4B  show the dose titration of the various constructs as measured by the secretion of IL-6 and IL-1 beta. The flagellin activity is dependent on the targeting antibody and is effective even at the lowest 0.1 nM dose, while the isotype control gives only a response at 25 nM dose.  FIGS. 4C and 4D  show the dose titration of the various constructs as measured by the secretion of IL-6 and IL-1 beta. The flagellin activity is dependent on the targeting antibody and is effective even at the lowest 0.1 nM dose, while the isotype control gives only a response at 25 nM dose. Moreover, the addition of free antibody to the isotype control does not restore the flagellin activity. 
         [0079]      FIG. 5  shows heat maps of gene expression for the listed genes using an anti-LOX-1 antibody with or without flagellin. Of the heat maps obtained from IFNα-DCs cultured with α-LOX-1.flgn, it was found that 17 transcripts are overexpressed in response to the αLOX-1.flgn stimuli. 
         [0080]    It is contemplated that any embodiment discussed in this specification can be implemented with respect to any method, kit, reagent, or composition of the invention, and vice versa. Furthermore, compositions of the invention can be used to achieve methods of the invention. 
         [0081]    It may be understood that particular embodiments described herein are shown by way of illustration and not as limitations of the invention. The principal features of this invention can be employed in various embodiments without departing from the scope of the invention. Those skilled in the art will recognize, or be able to ascertain using no more than routine experimentation, numerous equivalents to the specific procedures described herein. Such equivalents are considered to be within the scope of this invention and are covered by the claims. 
         [0082]    All publications and patent applications mentioned in the specification are indicative of the level of skill of those skilled in the art to which this invention pertains. All publications and patent applications are herein incorporated by reference to the same extent as if each individual publication or patent application was specifically and individually indicated to be incorporated by reference. 
         [0083]    The use of the word “a” or “an” when used in conjunction with the term “comprising” in the claims and/or the specification may mean “one,” but it is also consistent with the meaning of “one or more,” “at least one,” and “one or more than one.” The use of the term “or” in the claims is used to mean “and/or” unless explicitly indicated to refer to alternatives only or the alternatives are mutually exclusive, although the disclosure supports a definition that refers to only alternatives and “and/or.” Throughout this application, the term “about” is used to indicate that a value includes the inherent variation of error for the device, the method being employed to determine the value, or the variation that exists among the study subjects. 
         [0084]    As used in this specification and claim(s), the words “comprising” (and any form of comprising, such as “comprise” and “comprises”), “having” (and any form of having, such as “have” and “has”), “including” (and any form of including, such as “includes” and “include”) or “containing” (and any form of containing, such as “contains” and “contain”) are inclusive or open-ended and do not exclude additional, unrecited elements or method steps. 
         [0085]    The term “or combinations thereof” as used herein refers to all permutations and combinations of the listed items preceding the term. For example, “A, B, C, or combinations thereof” is intended to include at least one of: A, B, C, AB, AC, BC, or ABC, and if order is important in a particular context, also BA, CA, CB, CBA, BCA, ACB, BAC, or CAB. Continuing with this example, expressly included are combinations that contain repeats of one or more item or term, such as BB, AAA, MB, BBC, AAABCCCC, CBBAAA, CABABB, and so forth. The skilled artisan will understand that typically there is no limit on the number of items or terms in any combination, unless otherwise apparent from the context. 
         [0086]    All of the compositions and/or methods disclosed and claimed herein can be made and executed without undue experimentation in light of the present disclosure. While the compositions and methods of this invention have been described in terms of preferred embodiments, it may be apparent to those of skill in the art that variations may be applied to the compositions and/or methods and in the steps or in the sequence of steps of the method described herein without departing from the concept, spirit and scope of the invention. All such similar substitutes and modifications apparent to those skilled in the art are deemed to be within the spirit, scope and concept of the invention as defined by the appended claims. 
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       [0087]    U.S. Patent Application Publication No. 20090004194: TLR Agonist (Flagellin)/CD40 Agonist/Antigen Protein and DNA Conjugates and use Thereof for Inducing Synergistic Enhancement in Immunity. 
         [0088]    U.S. Patent Application Publication No. 20080220011: Use of Flagellin in Tumor Immunotherapy. 
         [0089]    U.S. Patent Application Publication No. 20080248068: Use of Flagellin as an Adjuvant for Vaccine. 
         [0090]    U.S. Pat. No. 7,404,963: Flagellin-Based Adjuvants and Vaccines.