Abstract:
Disclosed herein are compositions and methods for accurately estimating the absorbed dose of radiation indicated by a subject based on the expression pattern of a panel of radiation-modulated (RM) genes at various time points following exposure of the subject to ionizing radiation.

Description:
CROSS-REFERENCE TO RELATED APPLICATIONS 
       [0001]    This application claims the benefit of U.S. Provisional Application No. 62/038,969, filed Aug. 19, 2014, which is hereby incorporated by reference in its entirety for all purposes. 
     
    
     STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT 
       [0002]    Not Applicable. 
       BACKGROUND 
       [0003]    Radiation exposure is one of the most serious hazards of the modern era. The health consequences to individuals and populations exposed to radiological incidents, accidental or otherwise, can range from negligible to fatal depending on the amount of radiation that is absorbed by an individual. Yet, it is often difficult or impossible to quickly determine the absorbed dose of radiation for an individual or population after a radiological event and thereby determine an appropriate course of treatment. This is particularly critical when large numbers of individuals are potentially affected by radiation exposure and must be quickly “triaged” to prioritize treatment strategies. Thus, there is a great need for systems that quickly estimate, post-hoc, the absorbed dose of radiation by an individual resulting from an ionizing radiation exposure incident. 
       BRIEF SUMMARY OF THE INVENTION 
       [0004]    Disclosed herein are compositions and methods for accurately estimating the absorbed dose of radiation suffered by a subject based on the expression pattern in RNA obtained from peripheral blood of a panel of radiation-modulated (RM) genes at various time points following exposure of the subject to ionizing radiation. 
         [0005]    Accordingly in one aspect provided herein is a radiation biodosimetry assay system, comprising a plurality of nucleic acid amplification reactions comprising (i) mRNA or cDNA from a human subject suspected of (but not necessarily) suffering from radiation exposure; (ii) primer pairs capable of hybridizing under stringent conditions to mRNAs or cDNAs comprising the nucleotide sequences referred to in Table 4 or the complementary sequences thereof, wherein each primer pair hybridizes to a different one of the mRNAs or cDNAs; and (iii) a thermostable enzyme suitable for amplification of target amplicon sequences from the mRNAs or cDNAs. A mathematical algorithm that converts gene expression results to estimated absorbed dose of radiation. 
         [0006]    In some embodiments the one or more nucleic acid amplification reactions further comprise detectably labeled TaqMan® probes capable of hybridizing under stringent conditions to the mRNAs or cDNAs. In some embodiments the thermostable enzyme is a thermostable polymerase. 
         [0007]    In some embodiments the mRNA is from a subject that was exposed to radiation about 4-hours to about seven days prior to the time at which a biological sample comprising the mRNA was obtained. 
         [0008]    In another aspect provided herein is a radiation biomarker assay kit, comprising a nucleic acid probe set consisting essentially of nucleic acid probes that hybridize specifically with nucleic acid targets comprising at least one of the nucleotide sequences referred to in SEQ ID NOs: 1-29 or the complementary sequences thereof. In some embodiments the probe set comprises no more than 100 probes. In some embodiments the probe set consists of the nucleic acid probes that hybridize specifically with the nucleic acid targets. 
         [0009]    In some embodiments the nucleic acid probe set comprises primer pairs and TaqMan probes suitable for qPCR analysis of mRNAs or cDNAs comprising at least one of the nucleotide sequences referred to in SEQ ID NOS: 1-29 or the complementary sequences thereof. In some embodiments the nucleic acid probes are provided in a multi-well plate. In some embodiments, where the nucleic acid probes are provided in a multi-well plate, at least two nucleic acid probes that hybridize to at least two different nucleic acid targets are in the same wells of the multi-well plate. 
         [0010]    In some embodiments the kit also includes radiation exposure positive and negative control mRNA samples or cDNAs thereof. In another aspect provided herein is a method for assessing a dose of ionizing radiation absorbed by a subject, comprising (i) determining the mRNA expression levels of mRNAs comprising at least one of the nucleotide sequences referred to in SEQ ID NOs: 1-29 in a biological sample, comprising mRNA from the subject, to obtain an expression profile; and (ii) transforming the gene expression profile and when available, the duration of time from exposure to sample collection, into a measure of absorbed dose of radiation for the subject based on a mathematical algorithm. In one embodiment, the algorithm utilizes multiple random forest regression trees to estimate absorbed dose and confidence limits and then a top-level logic layer to combine outputs into a single estimated absorbed dose with confidence limits. 
         [0011]    In some embodiments the method further includes treating the subject based on the estimated absorbed dose of radiation determined in step (ii). 
         [0012]    In some embodiments the absorbed dose of ionizing radiation is determined within about seven days of subject exposure to ionizing radiation. 
         [0013]    In some embodiments the method also includes a step of obtaining the biological sample from the subject prior to step (i). 
         [0014]    In a further aspect provided herein is a method for radiation treatment triage of a subject in need thereof comprising (i) determining the mRNA expression levels of mRNAs comprising the nucleotide sequences referred to in at least one of SEQ ID NOs: 1-29 (or any other sequence identifier included herein, in any combination) in a biological sample comprising leukocyte mRNA from the subject to obtain a gene expression profile; and (ii) providing a suitable treatment for radiation exposure to the subject based on the expression levels of the genes. 
       INCORPORATION BY REFERENCE 
       [0015]    All publications, patents, and patent applications mentioned in this specification are herein incorporated by reference to the same extent as if each individual publication, patent, and patent application was specifically and individually indicated to be incorporated by reference. 
     
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
         [0016]    The present invention will be better understood and features, aspects and advantages other than those set forth above will become apparent when consideration is given to the following detailed description thereof. Such detailed description makes reference to the following drawings, wherein: 
           [0017]      FIG. 1A  show tables listing a set of 28 radiation modulated (RM) genes and their expression pattern at various time points following absorption of ionizing radiation. 
           [0018]      FIG. 1B  show tables listing a set of 28 radiation modulated (RM) genes and their expression pattern at various time points following absorption of ionizing radiation. 
           [0019]      FIG. 2  shows a time series (days 1-7) of plots of actual delivered ionizing radiation dosage values (0 Gy to 10 Gy) versus estimated absorbed dose of radiation based on changes in RM gene expression in peripheral blood 
           [0020]      FIG. 3  shows a table providing the percentage accuracy (within 1 Gy) of the biodosimetry algorithm&#39;s absorbed radiation dose estimate based on expression of 29 RM genes in peripheral blood collected from rhesus macaque non-human primate (NHPs) at various time points (1-7 days) following exposure to irradiation doses ranging from 0 Gy to 10 Gy. 
           [0021]      FIG. 4  shows a table providing the percentage accuracy (within 0.5 Gy) of the biodosimetry algorithm&#39;s absorbed radiation dose estimate based on expression of 29 RM genes in peripheral blood from NHPs at various time points (1-7 days) following exposure to irradiation doses ranging from 0 Gy to 10 Gy. 
           [0022]      FIG. 5  shows scatter plots of changes in RM gene expression in male vs. female NHPs following radiation exposure of various doses and at different time points following radiation exposure. As shown, male and female RM gene expression responses were very closely correlated for the 29 RM genes. 
           [0023]      FIG. 6  shows a table describing the sensitivity and specificity of the biodosimetry algorithm in various NHP and human irradiation models. 
           [0024]      FIG. 7  shows an overview of an exemplary, non-limiting, embodiment of biodosimetry workflow illustrating the steps of: blood sample collection, RNA isolation, reverse transcription to obtain cDNA, pre-amplification of the cDNA, and qPCR assay of a RM biomarker and reference gene panel. 
           [0025]      FIG. 8  shows a single regression tree in a random forest example. This tree generates an estimated absorbed dose using the relative expression levels of gene biomarkers, HBA2 and IL27RA, and the absolute expression level of gene biomarker, COCH. 
           [0026]      FIG. 9  shows a schematic overview on human and NHP data sets, cross-species conversion approaches to utilize the NHP single-dose (SD) biodosimetry algorithm to predict absorbed dose in human in case of acute radiation exposure. Cross-species conversion algorithms were developed with human and NHP fractionated-dose (FD) models that showed a good cross-model compatibility with NHP SD models. 
           [0027]      FIG. 10A  shows a schematic overview on the approach to convert NHP fractionated dose (FD) data to the corresponding values in NHP single-dose (SD) data by 3-dimensional linear scaling of day, dose, and expression values. 
           [0028]      FIG. 10B  shows the optimal range (in blue) of dose/day scaling factors for 12 Gy/day-6 data points of individual biomarkers (top panels) and a unified scaling factor (bottom panel) for 29 tested biomarkers. 
           [0029]      FIG. 11A  shows dose prediction performances of a random forests model based on 7 correlated biomarker genes on NHP SD data (for day 3, as an example). 
           [0030]      FIG. 11B  shows dose prediction performances of a random forests model based on 7 correlated biomarker genes on converted NHP FD values across all days by matching day/cumulative dose, 3D scaling, and 3D scaling followed by multi-gene regression. Prediction accuracies within 1.0 Gy are shown. 
           [0031]      FIG. 12A  shows correlation of individual biomarker expression values between NHP fractionated dose (FD) and human TBI, magnitude of expressional changes across dose, and mean absolute difference (MAD) between NHP FD and human TBI data points. 
           [0032]      FIG. 12B  shows dose response curves of the top 4 inter-species correlated genes in NHP FD and human TBI data. 
           [0033]      FIG. 13A  shows dose prediction performances of a random forests model based on 10 inter-species biomarker genes on NHP FD data. 
           [0034]      FIG. 13B  shows dose prediction performances of a random forests model based on 10 inter-species biomarker genes on unconverted and converted human TBI values by value shift, and value shift followed by multi-gene regression. Prediction accuracies within 1.0 Gy are shown. 
       
    
    
     DETAILED DESCRIPTION 
       [0035]    In General. 
         [0036]    Before the present materials and methods are described, it is understood that this invention is not limited to the particular methodology, protocols, materials, and reagents described, as these may vary. It is also to be understood that the terminology used herein is for the purpose of describing particular embodiments only, and is not intended to limit the scope of the present invention which will be limited only by the appended claims. 
         [0037]    It must be noted that as used herein and in the appended claims, the singular forms “a”, “an”, and “the” include plural reference unless the context clearly dictates otherwise. As well, the terms “a” (or “an”), “one or more” and “at least one” can be used interchangeably herein. It is also to be noted that the terms “comprising”, “including”, and “having” can be used interchangeably. 
         [0038]    Unless defined otherwise, all technical and scientific terms used herein have the same meanings as commonly understood by one of ordinary skill in the art to which this invention belongs. Although any methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, the preferred methods and materials are now described. All publications and patents specifically mentioned herein are incorporated by reference for all purposes including describing and disclosing the chemicals, cell lines, vectors, animals, instruments, statistical analysis and methodologies which are reported in the publications which might be used in connection with the invention. All references cited in this specification are to be taken as indicative of the level of skill in the art. Nothing herein is to be construed as an admission that the invention is not entitled to antedate such disclosure by virtue of prior invention. 
         [0039]    The Invention. 
         [0040]    The present invention provides methods for estimating absorbed dose of ionizing radiation by a subject, which includes the steps of: (i) determining the mRNA expression levels of mRNAs comprising the nucleotide sequences referred to in SEQ ID NOs: 1-29 in a biological sample comprising peripheral blood mRNA collected from the subject to obtain an expression profile; and (ii) transforming the gene expression profile and when available, the duration of time from exposure to sample collection into an estimated absorbed dose of ionizing radiation and confidence limits for a subject based on a mathematical algorithm. For each of several durations for which training data were available, one primary random forest was developed to estimate absorbed dose of radiation. Additional secondary random forests were developed to provide more accurate dosimetry in narrow dosage intervals. The top-level logic layer uses the primary random forest to generate an initial estimate of absorbed dose of radiation, and based on that value, may select additional random forests to construct more refined estimates of absorbed dose, with confidence limits. 
         [0041]    In some embodiments the method also includes treating the subject based on the absorbed dose of ionizing radiation determined in step (ii) above. In some embodiments the absorbed dose of ionizing radiation is determined within about seven days of exposure to the ionizing radiation, e.g., within about 30 minutes, 1 hour, 3 hours, 6 hours, 8 hours, 24 hours, 1 day, 2 days, 3 days, 4 days, 5 days, 6 days, or another time period within seven days following ionizing irradiation. In some embodiments, the absorbed dose of ionizing radiation is within the range of about 0.5 Grays (Gy) to about 10 Gy, e.g., about 1 Gy, 2 Gy, 3 Gy, 4 Gy, 6 Gy, 7 Gy, 8 Gy, 9 Gy, or another absorbed dose of ionizing radiation from about 0.5 Gy to about 10 Gy. 
         [0042]    In some embodiments, the method also includes obtaining the biological sample from the irradiated subject prior to step (i) above. 
         [0043]    In one embodiment, a whole blood sample, or other blood fraction containing lymphocytes, (including a finger stick or POC device) is collected from a subject known to be or suspected of being irradiated into a PAXgene™ Blood RNA tube. The PAXgene™ Blood RNA contains an additive that stabilizes in vitro gene expression and RNA degradation. Subsequently, RNA is extracted from the stabilized blood sample by using a Stabilized Blood-to-CT™ Nucleic Acid Preparation Kit for qPCR (Life Technologies, Inc.). The RNA sample is then subjected to reverse transcription, e.g., using the Invitrogen™ SuperScript® VILO™ (Variable Input, Linear Output) cDNA synthesis kit (Life Technologies, Inc.) or equivalent kit. Afterwards, the resulting cDNA is pre-amplified using a TaqMan® PreAmp Master Mix Kit (Life Technologies, Inc.) and the pre-amplified cDNA is then assayed by TaqMan®-based qPCR in a 96-well or 384-well format using QuantStudio™ Dx or ABI7500 Fast Dx quantitative Real-Time PCR Instruments (Life Technologies, Inc.). Typically, expression levels of RM mRNAs will be expressed as a difference in C T  between a test gene and a reference (“housekeeping”) gene C T . 
         [0044]    In some embodiments the panel of RM mRNAs to be assayed include at least some combination of mRNAs for one or all of the following (human) genes: CR2 (SEQ ID NO: 1), DHRS4L1 (SEQ ID NO: 2), HCK (SEQ ID NO: 3), IL1RAP (SEQ ID NO: 4), LYRM4 (SEQ ID NO: 5), MYC (SEQ ID NO: 6), TMEM63B (SEQ ID NO: 7), ALOX5 (SEQ ID NO: 8), CAMK4 (SEQ ID NO: 9), CDKN1A (SEQ ID NO: 10), COCH (SEQ ID NO: 11), DHRS4 (SEQ ID NO: 12), MICAL1 (SEQ ID NO: 13), MOB3B (SEQ ID NO: 14), NUSAP1 (SEQ ID NO: 15), IL27RA (SEQ ID NO: 16), HBA2 (SEQ ID NO: 17), PPM1F (SEQ ID NO: 18), PPP2R1A (SEQ ID NO: 19), CFLAR (SEQ ID NO: 20), DHRS13 (SEQ ID NO: 21), ACAA1 (SEQ ID NO: 22), INPP5J (SEQ ID NO: 23), OAZ1 (SEQ ID NO: 24), PNOC (SEQ ID NO: 25), PDE4B (SEQ ID NO: 26), SCARB1 (SEQ ID NO: 27), TMEM9B (SEQ ID NO: 28), PPP6R3 (SEQ ID NO: 29), CXXC5, CD97, TEX10, SPECC1, ALAS2, ALPK1, ESD, GPR183, PPM1K, and SLC6A6 (collectively, SEQ ID NOs: 1-29). 
         [0045]    In other embodiments RM mRNAs to be assayed can include at least some combination of one or all of the following genes: ADAM17, AKT1, ANK1, ANXA3, ARHGAP26, ARID4A, ATG2A, ATIC, BCL11A, BCL6, BID, CFLAR, CIT, CPVL, CYTH4, DDB2, DDX58, DTL, EHBPL1, FCGR2A, FGR, HPRT1, HSP90AB1, HTRA2, IDOL, IRF1, JMJD1C, KIAA0101, LARP4B, LRRC6, LYN, MAP3K11, MAPK3, MDM1, MKNK1, MXD1, NAIP, NFE2L2, NRG1, NUSAP, PCNA, PGK1, PMP22, RARA, RNASE6, RPL13A, RPL6, RPS14, SP110, SPOCK2, TAPBP, TBP, TCF3, TNFRSF1A, TNFRSF1B, TNFSF14, USP38, WDR48, XAF1, ZAK, NPM1, CPSF1, COASY, DNAJC10, DYNLRB1, ELK4, GPRIN, NDE1, PGS1, PPM1K, and PTAFR. In some embodiments, the reference gene to be assayed is PPP6R3. In other embodiments the reference gene to be assayed may be USP38, WDR48 or LARP4B or some combination thereof. 
         [0046]    In some embodiments, qPCR reactions are multiplexed such that multiple mRNAs (including a reference mRNA) are assayed in a single qPCR reaction. 
         [0047]    Also disclosed herein is a method for radiation treatment triage of a subject in need thereof, which includes the steps of: (i) determining the mRNA expression levels of mRNAs comprising the nucleotide sequences referred to in any of SEQ ID NOS: 1-29 (or any combination of any other SEQ ID NO provided herein) in a biological sample comprising mRNA from the subject to obtain an expression profile; and (ii) providing a suitable treatment for radiation exposure to the subject based on the expression levels of the genes. Exemplary treatments for radiation exposure based on radiation dosage are shown in Table 1 below: 
         [0000]    
       
         
               
             
               
               
               
               
               
               
             
               
               
               
               
               
               
               
             
           
               
                 TABLE 1 
               
             
             
               
                   
               
               
                 Exemplary treatments for radiation exposure based on radiation dosage. 
               
             
          
           
               
                   
                   
                   
                   
                 Very 
                   
               
               
                 Symptoms and 
                 Mild 
                 Moderate 
                 Severe 
                 severe 
                 Lethal (a) 
               
               
                 treatment strategy 
                 (1-2 Gy) 
                 (2-4 Gy) 
                 (4-6 Gy) 
                 (6-8 Gy) 
                 (&gt;8 Gy) 
               
               
                   
               
             
          
           
               
                 Vomiting 
                 Onset 
                 After 2 hr. 
                 After 1-2 
                 Within 
                 Within 30 
                 Within 10 min. 
               
               
                   
                 Incidence 
                 10-50% 
                 hrs. 
                 1 hr. 
                 min. 
                 100% 
               
               
                   
                   
                   
                 70-90% 
                 100% 
                 100% 
               
               
                 Diarrhea 
                 Onset 
                 None 
                 None 
                 Mild 3-8 
                 Heavy 1-3 
                 Heavy 
               
               
                   
                 Incidence 
                   
                   
                 hrs. &lt;10% 
                 hrs. &gt;10% 
                 Within min.-1 hr. 
               
               
                   
                   
                   
                   
                   
                   
                 almost 100% 
               
               
                 Headache 
                 Onset 
                 Slight 
                 Mild 
                 Moderate 
                 Severe 
                 Severe 
               
               
                   
                 Incidence 
                   
                   
                 4-24 hrs. 
                 3-4 hrs. 
                 1-2 hrs. 
               
               
                   
                   
                   
                   
                 50% 
                 80% 
                 80-90% 
               
               
                 Consciousness 
                 Onset 
                 Alert 
                 Alert 
                 Alert 
                 Possibility 
                 Unconsciousness 
               
               
                   
                 Incidence 
                   
                   
                   
                 of 
                 by order of seconds 
               
               
                   
                   
                   
                   
                   
                 impairment 
                 or minutes 
               
               
                   
                   
                   
                   
                   
                   
                 Seconds-minutes 
               
               
                   
                   
                   
                   
                   
                   
                 100% (&gt;50 Gy) 
               
               
                 Body 
                 Onset 
                 Normal 
                 Increased 
                 Fever 
                 High fever &lt;1 
                 High fever &lt;1 
               
               
                 Temperature 
                 Incidence 
                   
                 1-3 hrs. 
                 1-2 hrs. 
                 hrs. 100% 
                 hrs. 100% 
               
               
                   
                   
                   
                 10-80% 
                 80-100% 
               
               
                 Treatment 
                   
                 Outpatient 
                 Observation 
                 Treatment 
                 Treatment 
                 Palliative treatment 
               
               
                 Strategy 
                   
                 observation 
                 at general 
                 at 
                 at 
                 (a) (advanced 
               
               
                   
                   
                   
                 hospital, 
                 specialized 
                 specialized 
                 medical care 
               
               
                   
                   
                   
                 treatment at 
                 Hospital 
                 hospital 
                 including stem cell 
               
               
                   
                   
                   
                 specialized 
                   
                   
                 transplantation) 
               
               
                   
                   
                   
                 hospital if 
               
               
                   
                   
                   
                 required 
               
               
                   
               
             
          
         
       
     
         [0048]    Also described herein is a radiation biodosimetry assay system that includes multiple nucleic acid amplification reactions containing the following: (i) mRNA or cDNA from a human subject suspected of suffering from radiation exposure; (ii) primer pairs capable of hybridizing under stringent conditions to mRNAs or cDNAs comprising the nucleotide sequences referred to in SEQ ID NOS: 1-29 (or any other SEQ ID NO provided herein), or the complementary sequences thereof, wherein each primer pair hybridizes to a different one of the mRNAs or cDNAs; and (iii) A mathematical algorithm the converts gene expression results to estimated absorbed dose of radiation. 
         [0049]    In one embodiment, the mathematical algorithm of the present invention The Radiation Biodosimetry Absorbed Dose Estimation algorithm described herein takes as input sample qPCR data, sample barcode, and available information about the date and time of the exposure event and sample collection. The primary output of the algorithm is an absorbed dose report that contains an estimated absorbed dose and a dose interval that provides a range of dose values for the patient based on prediction intervals. The algorithm contains 6 basic steps, which are summarized in Table 2. 
         [0050]    In Step 1, patient qPCR data are combined with the available information about the date and time of the event and sample collection using the patient barcode. 
         [0051]    In Step 2, several quality control metrics are calculated for the qPCR data. Depending on the values of these metrics, the algorithm may determine that a sample requires re-testing. If the sample does not require re-testing, the quality control metrics will be utilized in the estimation of absorbed radiation dose, and in particular may affect the estimation interval. 
         [0052]    In step 3, the qPCR data are checked against expected ranges for each biomarker. 
         [0053]    In step 4, quality control metrics and the results of the biomarker range checks are used to determine whether specific biomarker values are invalid and whether sufficient biomarker values are valid for dose estimation. 
         [0054]    In step 5, the qPCR data and the available temporal information for the event and sample collection are processed through a random forest-based mathematical algorithm that yields an estimated dose and a dose interval. The mathematical algorithm in Step 5 utilizes Random Forests™ method, introduced by Breiman (2001). Random forests is a popular machine-learning tool for prediction that combines large numbers of classification or regression trees to yield accurate and robust predictions. A random forest is a collection of classification or regression trees that we denote by R={T 1 , . . . , T n }. The input to the forest is a vector X of relative and/or absolute expression levels of a set of genes. In a regression random forest, each tree T i  takes X as input and outputs an estimate of absorbed dose, T i (X). For example,  FIG. 8  depicts a single tree in a random forest that utilizes the relative expression levels for two gene biomarkers (HBA2 and IL27RA) and the absolute expression level for one gene biomarker (COCH). The estimate of absorbed dose from a regression random forest R is then the average of estimated absorbed doses from the trees within the forest. We write this estimate as: 
         [0000]    
       
         
           
             AD 
             = 
             
               
                 R 
                  
                 
                   ( 
                   X 
                   ) 
                 
               
               = 
               
                 
                   1 
                   n 
                 
                 × 
                 
                   
                     ∑ 
                     
                       i 
                       = 
                       1 
                     
                     n 
                   
                    
                   
                       
                   
                    
                   
                     
                       T 
                       i 
                     
                      
                     
                       ( 
                       X 
                       ) 
                     
                   
                 
               
             
           
         
       
     
         [0055]    In a classification random forest, samples are partitioned into several non-intersecting groups. For example, samples may be partitioned based upon dose and each group then represents an interval for the absorbed dose. Each tree T i  takes as input X and outputs the identity of a single group, T i (X). The output from the classification random forest is a probability distribution on the set of groups, where the probability assigned to each group is the proportion of trees that yield the group. 
         [0056]    The inputs to the mathematical algorithm in Step 5 are a set of absolute and relative expression levels, X for a set of genes, and a probability distribution π that reflects the uncertainty in D, the duration of time from irradiation to sample collection. If the duration of time is known precisely, π will be a point mass distribution on that known duration of time. If the duration is only known to fall within an interval, then π may be any probability distribution on that interval such as a uniform distribution or a symmetric triangular distribution. If the duration is entirely unknown or not provided, then π may be calculated using a classification random forest that takes as input X and yields as output a probability distribution over a fixed set of duration values. 
         [0057]    The outputs are an estimated absorbed dose, AD and a 95% prediction interval for the absorbed dose, (AD low ,AD high ). For NHP samples that were irradiated with a single acute dose (NHP SD), these outputs are computed in two steps. First, we compute an initial estimate of absorbed dose, AD I . Secondly, we correct for bias in the estimate to yield the final estimate of absorbed dose, AD and generate the 95% prediction interval. 
         [0058]    A novel aspect of our algorithm is the use of multiple random forests for each of several fixed durations, D 1 , . . . , D k . For duration D i , we use n i  random forests, denoted by RF i,1 , . . . , RF i,n     i   , to construct initial estimates of absorbed dose. A decision tree T i  combines the outputs from RF i,1 , . . . , RF i,n     i    into a single initial estimate of absorbed dose. One additional random forest, denoted by RF i   E , is a quantile regression random forest for error that uses the expression values X′ and the output from T i  for bias correction and construction of prediction intervals. These n i +1 random forests utilize different, but possibly overlapping sets of genes, may be trained on different sets of samples and may include both regression forests and classification forests. Hence, if the duration is known to equal D i , the initial estimate of absorbed dose, denoted by AD I (D i ), is computed as: 
         [0000]      AD I ( D   i )= T   i (RF i,1 ( X ′), . . . , RF i,n     i   ( X ′))
 
         [0059]    This estimate and the transformed expression levels X′ are then passed to the random forest RF i   E . The output from RF i   E  is the conditional probability distribution for the error in the estimate AD I (D i ). We denote the cumulative distribution function for this conditional distribution by F (•|D=D i ). The bias corrected estimate of absorbed dose is then AD(D i )=AD I (D i )−F −1 (0.5). If the duration is known to equal D* where D i &lt;D*&lt;D i+1 , the estimated absorbed dose is computed as: 
         [0000]    
       
         
           
             
               AD 
                
               
                 ( 
                 
                   D 
                   * 
                 
                 ) 
               
             
             = 
             
               
                 
                   
                     
                       D 
                       
                         i 
                         + 
                         1 
                       
                     
                     - 
                     
                       D 
                       * 
                     
                   
                   
                     
                       D 
                       
                         i 
                         + 
                         1 
                       
                     
                     - 
                     
                       D 
                       i 
                     
                   
                 
                 × 
                 
                   AD 
                    
                   
                     ( 
                     
                       D 
                       i 
                     
                     ) 
                   
                 
               
               + 
               
                 
                   
                     
                       D 
                       * 
                     
                     - 
                     
                       D 
                       i 
                     
                   
                   
                     
                       D 
                       
                         i 
                         + 
                         1 
                       
                     
                     - 
                     
                       D 
                       i 
                     
                   
                 
                 × 
                 
                   AD 
                    
                   
                     ( 
                     
                       D 
                       
                         i 
                         + 
                         1 
                       
                     
                     ) 
                   
                 
               
             
           
         
       
     
         [0060]    The final estimate of absorbed dose is computed by averaging over the probability distribution π, that is, AD=∫AD(D)×π(D)dD. 
         [0061]    Similarly, we define F(•|D=D*) by: 
         [0000]    
       
         
           
             
               F 
                
               
                 ( 
                 
                   
                     · 
                     
                        
                       D 
                     
                   
                   = 
                   
                     D 
                     * 
                   
                 
                 ) 
               
             
             = 
             
               
                 
                   
                     
                       D 
                       
                         i 
                         + 
                         1 
                       
                     
                     - 
                     
                       D 
                       * 
                     
                   
                   
                     
                       D 
                       
                         i 
                         + 
                         1 
                       
                     
                     - 
                     
                       D 
                       i 
                     
                   
                 
                 × 
                 
                   F 
                    
                   
                     ( 
                     
                       
                         · 
                         
                            
                           D 
                         
                       
                       = 
                       
                         D 
                         i 
                       
                     
                     ) 
                   
                 
               
               + 
               
                 
                   
                     
                       D 
                       * 
                     
                     - 
                     
                       D 
                       i 
                     
                   
                   
                     
                       D 
                       
                         i 
                         + 
                         1 
                       
                     
                     - 
                     
                       D 
                       i 
                     
                   
                 
                 × 
                 
                   F 
                    
                   
                     ( 
                     
                       
                         · 
                         
                            
                           D 
                         
                       
                       = 
                       
                         D 
                         
                           i 
                           + 
                           1 
                         
                       
                     
                     ) 
                   
                 
               
             
           
         
       
     
         [0062]    The 95% prediction interval for the absorbed dose is then found by solving the equations: 
         [0000]      ∫ F ( e   1   |D )×π( D ) dD= 0.025, and
 
         [0000]      ∫ F ( e   2   |D )×π( D ) dD= 0.975
 
         [0000]    for e 1  and e 2 , respectively, and setting AD low =AD−e 2  and AD high =AD−e 1 . 
         [0063]    In step 6, an absorbed dose estimation report is constructed utilizing the estimated dose and dose interval. 
         [0064]    In actual events of acute radiation exposure, to predict absorbed dose of human samples with the NHP-based biodosimetry algorithm, conceptually, gene expression measurements of each biomarker in a human sample need to be transformed by cross-species (i.e. human to NHP) algorithms. Ideal cross-conversion models could be built on two directly comparable single-dose (SD) data sets in human and NHP. However, due to practical difficulties in obtaining human blood samples with single acute irradiation, as an alternative, we obtain samples from human subjects who undergo total body irradiation (TBI). Unlike the acute single-dose (SD) irradiation that we used for development of a biodosimetry algorithm, these subjects under a fractionated dose (FD) schedule were irradiated three times (1.2 Gy each) a day for 6 days. Therefore, we obtained gene expression data from NHP-equivalents of human TBI subjects that underwent the identical fractionated irradiation, and developed novel gene-specific cross-species conversion algorithms. These algorithms will be used to transform human values prior to dose prediction ( FIG. 9 ). 
         [0065]    Unlike SD models that measure gene expression levels over the time after a single acute irradiation, data from a FD model has a linear relationship between cumulative dose and day. Therefore, prior to development of cross-species conversion algorithms based on human and NHP FD data sets, we first examined whether expression profiles of biomarker genes in NHP FD model were comparable to those in NHP SD model and thus could predict absorbed dose via the NHP SD model-based biodosimetry algorithm. For meta analyses of FD and SD data sets, we developed a three-dimensional (3D) curve fitting strategy to match the FD data to the SD data. Specifically, for each biomarker b we generate an FD curve of the mean expression level of NHP FD samples (2 Gy per day for 6 days) as a function of cumulative dose and day, FD b (dose, day), and a SD response surface of the mean expression level of NHP SD samples (0 to 6 days, 0 to 7 Gy) as a function of dose and day, SD b (dose, day) ( FIG. 10A ). First, the entire FD curve for each biomarker is shifted to match the mean basal level (i.e. 0 Gy/Day 0) of SD values, which produces a scaling factor α b  for expression values for each biomarker. The shifted FD curve is denoted FD b ′(dose, day)=FD b (dose, day)+α b , where α b =SD b (0, 0)−FD b (0, 0). Second, for each biomarker, optimal biomarker-specific dose and day scaling factors, β b,dose  and β b,day , are found that minimize the sum of absolute differences between the SD and scaled FD data. 
         [0066]    Specifically, β b,dose  and β b,day  minimize the following expression, 
         [0000]    
       
         
           
             
               ∑ 
               
                 
                   d 
                    
                   
                       
                   
                    
                   1 
                 
                 , 
                 
                   d 
                    
                   
                       
                   
                    
                   2 
                 
               
             
              
             
                 
             
              
             
                
               
                 
                   
                     
                       
                         FD 
                         b 
                         ′ 
                       
                        
                       
                         ( 
                         
                           
                             d 
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                              
                             1 
                           
                           , 
                           
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                              
                             
                                 
                             
                              
                             2 
                           
                         
                         ) 
                       
                     
                     
                       
                         FD 
                         b 
                         ′ 
                       
                        
                       
                         ( 
                         
                           12 
                           , 
                           6 
                         
                         ) 
                       
                     
                   
                   × 
                   
                     
                       SD 
                       b 
                     
                      
                     
                       ( 
                       
                         
                           
                             β 
                             
                               b 
                               , 
                               dose 
                             
                           
                           × 
                           d 
                            
                           
                               
                           
                            
                           1 
                         
                         , 
                         
                           
                             β 
                             
                               b 
                               , 
                               day 
                             
                           
                           × 
                           d 
                            
                           
                               
                           
                            
                           2 
                         
                       
                       ) 
                     
                   
                 
                 - 
                 
                   
                     SD 
                     b 
                   
                    
                   
                     ( 
                     
                       
                         
                           β 
                           
                             b 
                             , 
                             dose 
                           
                         
                         × 
                         d 
                          
                         
                             
                         
                          
                         1 
                       
                       , 
                       
                         
                           β 
                           
                             b 
                             , 
                             day 
                           
                         
                         × 
                         d 
                          
                         
                             
                         
                          
                         2 
                       
                     
                     ) 
                   
                 
               
                
             
           
         
       
     
         [0067]    By repeating this for all biomarkers and searching for common dose and day scaling factors that minimize the sum of absolute differences across biomarkers, doses and days, unified FD to SD scaling factors of β dose =0.517 for dose (i.e. 12 Gy to 6.2 Gy) and β day =0.933 for day (i.e. day 6 to day 5.6) ( FIG. 10B ) are obtained. 
         [0068]    Mathematically, β dose  and β day  are defined to minimize 
         [0000]    
       
         
           
             
               ∑ 
               b 
             
              
             
                 
             
              
             
               
                 ∑ 
                 
                   
                     d 
                      
                     
                         
                     
                      
                     1 
                   
                   , 
                   
                     d 
                      
                     
                         
                     
                      
                     2 
                   
                 
               
                
               
                   
               
                
               
                 
                    
                   
                     
                       
                         
                           
                             FD 
                             b 
                             ′ 
                           
                            
                           
                             ( 
                             
                               
                                 d 
                                  
                                 
                                     
                                 
                                  
                                 1 
                               
                               , 
                               
                                 d 
                                  
                                 
                                     
                                 
                                  
                                 2 
                               
                             
                             ) 
                           
                         
                         
                           
                             FD 
                             b 
                             ′ 
                           
                            
                           
                             ( 
                             
                               12 
                               , 
                               6 
                             
                             ) 
                           
                         
                       
                       × 
                       
                         
                           SD 
                           b 
                         
                          
                         
                           ( 
                           
                             
                               
                                 β 
                                 dose 
                               
                               × 
                               d 
                                
                               
                                   
                               
                                
                               1 
                             
                             , 
                             
                               
                                 β 
                                 day 
                               
                               × 
                               d 
                                
                               
                                   
                               
                                
                               2 
                             
                           
                           ) 
                         
                       
                     
                     - 
                     
                       
                         SD 
                         b 
                       
                        
                       
                         ( 
                         
                           
                             
                               β 
                               dose 
                             
                             × 
                             d 
                              
                             
                                 
                             
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                           , 
                           
                             
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                    
                 
                 . 
               
             
           
         
       
     
         [0069]    Third, linear transformation of FD curves by the scaling factors yields the converted expression values, 
         [0000]    
       
         
           
             
               
                 
                   
                     
                       FD 
                       b 
                       ″ 
                     
                      
                     
                       ( 
                       
                         
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                            
                           
                               
                           
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                           1 
                         
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                       ) 
                     
                   
                   = 
                   
                     
                       
                         
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                           b 
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                             , 
                             
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                           ) 
                         
                       
                       
                         
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                           b 
                           ′ 
                         
                          
                         
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                             12 
                             , 
                             6 
                           
                           ) 
                         
                       
                     
                     × 
                     
                       
                         
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                           b 
                         
                          
                         
                           ( 
                           
                             
                               
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                                 dose 
                               
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                               d 
                                
                               
                                   
                               
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                             , 
                             
                               
                                 β 
                                 day 
                               
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                           ) 
                         
                       
                       . 
                     
                   
                 
               
               
                 
                   ( 
                   
                     
                       FIG 
                       . 
                       
                           
                       
                        
                       10 
                     
                      
                     A 
                   
                   ) 
                 
               
             
           
         
       
     
         [0070]    To test the conversion strategy from NHP FD to NHP SD data, based on seven biomarkers (COCH, DHRS4L1, IL27RA, INPP5J, PNOC, SCARB1, and TEX10 in this example) with correlated dose responses between the data sets, random forests dose prediction models were generated on NHP SD data, which showed 84% to 98% dose prediction accuracy across days for the model fitting on NHP SD data ( FIG. 11A ). When expression values of NHP FD data were converted by matching days or doses and then applied to the NHP SD random forests model, dose prediction accuracies within 1.0 Gy were only 21% and 31%, respectively. After the FD values were transformed by the 3D scaling factors (i.e. for expression value, dose, and day), the accuracy was increased to 60% ( FIG. 11B ). 
         [0071]    To increase performance of conversion algorithm, we explored a multi-gene regression approach that utilizes linear combinations of gene expression values rather than the expression values of individual biomarkers. This concept has been applied to predict missing values in large gene expression data sets. Since the biomarkers are functionally related within the key biological pathways related to radiation response, we hypothesized that expression profiles of other biomarkers could be informative in predicting expression values of a given gene. We employed Ridge regressions that provide robustness by constraining the size of coefficients by minimizing the summed squares of residuals and coefficients. By using converted NHP FD values by 3D scaling, a multi-gene regression model for each biomarker was generated with all seven genes that were used to build NHP SD biodosimetry algorithm. When the predicted values by the multi-gene regression models were applied to NHP SD algorithm, dose prediction accuracy was increased substantially to 86% ( FIG. 11B ). 
         [0072]    Absolute gene expression values of biomarker genes are highly variable between NHP and human, and, thus, using an NHP biodosimetry algorithm to predict absorbed dose in human requires another step of cross-species expression value transformation from human to NHP. To explore the conversion strategies, we compared two data sets, for human and NHP, that were obtained from subjects treated with an identical irradiation schedule (3 times of irradiation at 1.2 Gy per day for 4 days), which is being used for total body irradiation (TBI) in clinical therapeutic setting. Among 29 biomarkers tested, although 17 genes had inter-species correlation coefficient above 0.6 between these two data sets ( FIG. 12A ), many genes showed substantial differences in absolute expression levels across doses ( FIG. 12B ). Therefore, we calculated the mean difference of expression for each biomarker and then applied the value to shift the entire expression values the gene across doses. This process decreased the mean absolute differences to less than 1.0 ΔCt for the majority of 29 biomarkers ( FIG. 12A , last two columns). 
         [0073]    To test the conversion strategy from human TBI to NHP FD data, based on 10 biomarkers (DHRS4L1, MYC, SPECC1, CXXC5, ALAS2, HBA2, CDKN1A, GPR183, MOB3B, and PNOC in this example) with inter-species correlation above 0.75 ( FIG. 12A ), random forests dose prediction models were generated on NHP FD data, which showed a 98% dose prediction accuracy during the model fitting on NHP FD data ( FIG. 13A ). Appling the converted human TBI values to NHP FD random forests model, prediction accuracy within 1.0 Gy was 13%. When expression values of human TBI data were vertically shifted by the predetermined shift factors and then applied to the NHP FD random forests model, dose prediction accuracies within 1.0 Gy was increase marginally to 19%. 
         [0074]    We then tested whether the multi-gene regression approaches could improve the cross-species conversion process. As previously done for NHP FD to NHP SD conversion, we also employed Ridge regressions. By using converted human TBI values by vertical shifting factors, a multi-gene regression model for each biomarker was generated with all 10 genes that were used to build the NHP FD biodosimetry algorithm in this example. When the predicted values by the multi-gene regression models were applied to NHP FD algorithm, dose prediction accuracy was increased substantially to 89%. 
         [0000]    
       
         
               
             
               
               
               
               
               
               
               
             
           
               
                 TABLE 2 
               
               
                   
               
               
                 Algorithm Function. 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                 Step 1 
                 Combine 
                 Traceability 
                 Barcode 
                 Unique barcode 
                 Adds all needed 
                 Flags data for operator 
               
               
                   
                 Patient 
                   
                   
                   
                 information to 
                 intervention 
               
               
                   
                 Barcode with 
                   
                   
                   
                 qPCR data 
               
               
                   
                 Date/Time 
               
               
                   
                 Event 
               
               
                 Step 2 
                 Quality Control 
                 Negative 
                 96-Well Prep Plate No 
                 Ct (Ref)(2) &gt; 37 
                 Cross- 
                 Retest Samples 
               
               
                   
                 Check 
                 Control 
                 Template Control 
                   
                 Contamination in 
               
               
                   
                   
                   
                 (NTC) or Reagent 
                   
                 Sample Prep 
               
               
                   
                   
                   
                 Blank 
               
               
                   
                   
                 Positive 
                 qPCR Standard 
                 1. Ct (Ref) ± 1 
                 1. LLOD Verified 
                 Flags data- may affect 
               
               
                   
                   
                 Controls 
                 Curve: 10, 0.1, 0.01, 
                 each conc. 
                 2. Reproducibility 
                 Doses Estimate and 
               
               
                   
                   
                   
                 0.001 ng/μL 
                 2. Amplification 
                 Verified 
                 Dose interval 
               
               
                   
                   
                   
                 (Based on standard 
                 Efficiency 
                 3. Amplification 
                 Or 
               
               
                   
                   
                   
                 pooled RNA). 
                   
                 verifies 
                 Require sample retest 
               
               
                   
                   
                   
                   
                   
                 expected qPCR 
                 and 
               
               
                   
                   
                   
                   
                   
                 function across 
                 Alerts Operator (No 
               
               
                   
                   
                   
                   
                   
                 linear range. 
                 operator override) 
               
               
                   
                   
                   
                 Exogenous Control: 
                 Ct (Xeno ™) ± 1 
                 Inhibitors 
               
               
                   
                   
                   
                 Sample RNA Spike-in 
                   
                 Sample Integrity 
               
               
                   
                   
                   
                 Endogenous Control: 
                 Ct (Ref) ± 1 
                 1. Adequate 
               
               
                   
                   
                   
                 Reference Gene(1) 
                   
                 Sample RNA 
               
               
                   
                   
                   
                   
                   
                 Input. 
               
               
                   
                   
                   
                   
                   
                 2.Control for 
               
               
                   
                   
                   
                   
                   
                 variable RNA 
               
               
                   
                   
                   
                   
                   
                 input 
               
               
                 Step 3 
                 Biomarker 
                 Process QC 
                 Biomarker integrity 
                 QC flag 
                 Usability of each 
               
               
                   
                 Range Check 
                   
                   
                   
                 Biomarker Value 
               
               
                 Step 4 
                 Apply QC and 
                 Process QC 
                 Analytical integrity 
                 QC flag 
                 Usability of each 
               
               
                   
                 Biomarker 
                   
                   
                   
                 Biomarker Value 
               
               
                   
                 Range Flags 
               
               
                 Step 5 
                 Calculate 
                 Quantitative 
                 Endogenous Control 
                 Absorbed dose 
                 Estimated 
                 Checks for intended 
               
               
                   
                 Estimated 
                   
                   
                 (Gy) 
                 absorbed Dose 
                 use dose range 
               
               
                   
                 Dose 
               
               
                   
                 Calculate Dose 
                 Measurement 
                 Confidence Interval 
                 Dose Range 
                 Dose Interval 
                 Checks for acceptable 
               
               
                   
                 Interval 
                 Confidence 
                   
                   
                   
                 confidence interval 
               
               
                 Step 6 
                 Combine 
                 Report 
                 Report 
                 Gy 
                 Dose Estimation 
                 Clinic 
               
               
                   
                 Estimated 
                   
                   
                   
                 Report 
                 Review/Approval 
               
               
                   
                 Dose and 
               
               
                   
                 Dose Interval 
               
               
                   
               
             
          
         
       
     
         [0075]    In one embodiment, the target mRNAs or cDNAs to which the primers hybridize are those from the following (human) RM genes: CR2, DHRS4L1, HCK, IL1RAP, LYRM4, MYC, TMEM63B, ALOX5, CAMK4, CDKN1A, COCH, DHRS4, MICAL1, MOB3B, NUSAP1, IL27RA, HBA2, PPM1F, PPP2R1A, CFLAR, DHRS13, ACAA1, INPP5J, OAZ1, PNOC, PDE4B, SCARB1, and TMEM9B. 
         [0076]    In other embodiments, mRNAs or cDNAs to which primers hybridize may include the following genes: ADAM17, AKT1, ANK1, ANXA3, ARHGAP26, ARID4A, ATG2A, ATIC, BCL11A, BCL6, BID, CFLAR, CIT, CPVL, CYTH4, DDB2, DDX58, DTL, EHBPL1, FCGR2A, FGR, HPRT1, HSP90AB1, HTRA2, IDOL, IL27RA, IRF1, JMJD1C, KIAA0101, LARP4B, LRRC6, LYN, MAP3K11, MAPK3, MDM1, MKNK1, MXD1, NAIP, NFE2L2, NRG1, NUSAP, PCNA, PGK1, PMP22, PPP2RA1, RARA, RNASE6, RPL13A, RPL6, RPS14, SCARB1, SP110, SPOCK2, TAPBP, TBP, TCF3, TNFRSF1A, TNFRSF1B, TNFSF14, USP38, WDR48, XAF1, ZAK, NPM1, ALAS2, ALPK1, CD97, CPSF1, COASY, CXXC5, DNAJC10, DYNLRB1, ELK4, ESD, GPR183, GPRIN, NDE1, PGS1, PPM1K, PTAFR, SLC6A6, SPECC1, and TEX10. 
         [0077]    In some embodiments, primers are also included that hybridize to PPP6R3 mRNA or cDNA, where PPP6R3 and its mRNA levels serve as a reference gene for relative quantification of RM gene expression levels in an amplification reaction. In other embodiments primers may be included that hybridize to USP38, WDR48 or LARP4B mRNA or cDNA to serve as the reference gene or some combination thereof. 
         [0078]    In some embodiments, the nucleic acid amplification reactions are qPCR reactions. In some embodiments the qPCR reactions are TaqMan® qPCR reactions that include, in addition to the target primer pairs, TaqMan® probes that hybridize under stringent conditions to the RM gene or reference gene mRNAs or cDNAs. TaqMan® probe-based qPCR assays are well known in the art as described in, e.g., U.S. Pat. Nos. 5,677,152, 5,773,258 and 5,804,375. 
         [0079]    Exemplary RM and reference gene primer and TaqMan probe sequences are listed below in Table 3. 
         [0000]    
       
         
               
             
               
               
               
               
               
             
           
               
                 TABLE 3 
               
             
             
               
                   
               
               
                 RM and reference gene primer and TaqMan probe  
               
               
                 sequences. 
               
             
          
           
               
                   
                 Assay 
                   
                 Length 
                   
               
               
                 Gene 
                 ID 
                 Amplicon Sequence 
                 (bp) 
                 Tm 
               
               
                   
               
               
                 PPP6R3 
                 Hs002177 
                 TGAGGGAGGAAGACGGCATGGTTAC 
                 76 
                 55- 
               
               
                   
                 59_m1 
                 ATGGGACACCTAACGAGGATAGCTA 
                   
                 65°  
               
               
                   
                   
                 ACTGTATCGTGCACAGCACTGACAAG 
                   
                 C. 
               
               
                   
                   
                 (SEQ ID NO: 30) 
                   
                   
               
               
                   
               
               
                 CDKN1A 
                 Hs002177 
                 GACAGATTTCTACCACTCCAAACGCC 
                 66 
                 55- 
               
               
                   
                 59_m1 
                 GGCTGATCTTCTCCAAGAGGAAGCCC 
                   
                 65°  
               
               
                   
                   
                 TAATCCGCCCACAG 
                   
                 C. 
               
               
                   
                   
                 (SEQ ID NO: 31) 
               
               
                   
               
             
          
         
       
     
         [0080]    Typically, stringent hybridization reaction conditions are defined by use of TaqPath™ qPCR Mastermix chemistry and cycling conditions listed below in Table 4. 
         [0000]    
       
         
               
             
               
               
               
               
             
               
               
               
               
               
             
               
               
             
           
               
                 TABLE 4 
               
             
             
               
                   
               
               
                 Thermal Cycling Conditions for Target/Primer/Probe Hybridization. 
               
             
          
           
               
                   
                   
                   
                 PCR 
               
               
                   
                 Incubation 
                 Activation 
                 Cycle (40 cycles) 
               
             
          
           
               
                 Step 
                 Hold 
                 Hold 
                 Denature 
                 Anneal/Extend 
               
               
                   
               
               
                 Temperature 
                 50° C. 
                 95° C. 
                 95° C. 
                 60° C. 
               
               
                 Time 
                 2 min. 
                 20 sec. 
                 1 sec. 
                 20 sec. 
               
             
          
           
               
                 Volume 
                 10 μL 
               
               
                   
               
             
          
         
       
     
         [0081]    In some embodiments the plurality of nucleic acid amplification reactions are multiplexed such that multiple mRNAs (including a reference mRNA) are assayed in a single qPCR reaction, i.e., nine qPCR reactions would be needed to assay the entire panel of RM gene mRNAs from one sample, where each of the reactions are “tetraplexed,” 14 reactions would be needed per sample where each reaction is “triplexed”, and 28 reactions would be needed per sample when each qPCR reactions includes primers to a single RM gene mRNA and a reference gene mRNA. In some embodiments, the plurality of qPCR reactions can include different multiplexing, i.e., some reactions may contain primer pairs directed to three RM gene mRNAs and others a primer pair to only two or a single RM gene mRNA. The plurality of reactions can be provided in a number of formats, e.g., 96-, 384-, or even 1536-well formats. 
         [0082]    In various embodiments, the mRNA or cDNA in the biodosimetry assay system is from a biological sample from a subject subjected to radiation exposure from about 30 minutes to about seven days prior to the time point at which the biological sample was obtained from the subject, e.g., one hour, three hours, 4 hours, six hours, twelve hours, 1 day, 2 days, 3 days, 4 days, 5 days, 7 days or another time period before biological sample collection from the subject ranging from about 30 minutes to about seven days. 
         [0083]    Also contemplated herein is a radiation biomarker assay kit that includes a nucleic acid probe set consisting essentially of nucleic acid probes that hybridize specifically with nucleic acid targets comprising at least one of SEQ ID NOS: 1-29 or the complementary sequences thereof. 
         [0084]    In some embodiments the probe set includes no more than about 200 probes, e.g., PCR primers. In other embodiments the probe set includes no more than about 100 probes. 
         [0085]    In some embodiments the nucleic acid probe set includes primer pairs and TaqMan probes suitable for qPCR analysis of mRNAs or cDNAs comprising at least one of SEQ ID NOS: 1-29. 
         [0086]    In some embodiments the kit also includes a thermostable polymerase suitable for qPCR, e.g., Taq polymerase and variants thereof known in the art. 
         [0087]    In some embodiments a qPCR probe set in the kit is provided in a multi-well plate format. In some a multi-well plate is provided in which at least two nucleic acid probes that hybridize to at least two different nucleic acid targets are in the same wells, i.e., the probes can be multiplexed, as described above such that up to four different targets can be assayed by qPCR in the same reaction. 
         [0088]    In some embodiments the kit also includes radiation exposure positive and negative control mRNA samples, which ensure that a qPCR biodosimetry assay is working properly, i.e., modulation of RM gene expression is detected in the positive control sample and no modulation of RM gene expression is detected in the negative control sample. 
       EXAMPLES 
       [0089]    The invention will be more fully understood upon consideration of the following non-limiting Examples. The invention has been described in connection with what are presently considered to be the most practical and preferred embodiments. However, the present invention has been presented by way of illustration and is not intended to be limited to the disclosed embodiments. Accordingly, those skilled in the art will realize that the invention is intended to encompass all modifications and alternative arrangements within the spirit and scope of the invention as set forth in the appended claims. 
       Example 1 
     Description of Test Experiments Used to Develop Biomarkers 
       [0090]    Rhesus macaque non-human primate (NHP) in vivo testing was conducted to produce single-dose biodosimetry samples and age/gender confounded samples to calibrate the biodosimeter. 
         [0091]    NHP In Vivo Dose Response to Radiation: 
         [0092]    The animal test laboratory completed NHP Cobalt-60 irradiations at 0, 2, 4, and 6 (LD30/60), 7 Gy (LD70/60), and 10 Gy with cohorts of 16 (8 male and 8 female), at dose rate of approximately 0.6 Gy/min. Samples of 2.5 ml peripheral blood (PAXgene tube) were obtained from each rhesus macaque −2 week and −24 hr. prior to irradiation and 4 hr., 24 hr., 36 hr. post radiation, and on days 2, 3, 5, and 7 for a total of 9 blood draws per animal. Samples (0.5 ml) were also obtained in EDTA tubes to determine WBC differentials. Tests were staged to provide 4 NHP at each condition to determine target genes using discovery techniques (Phase 1), 10 NHP at each condition to determine biomarkers and 2 NHP at each condition to test the biodosimeter (algorithm) accuracy (Phase 2). 
         [0093]    NHP Confounder Analysis; Old Age and Juvenile. 
         [0094]    The animal test laboratory completed testing of 4 rhesus macaques (2 male and 2 female) exposed to 6 Gy (LD30/60) at a dose rate of approximately 0.6 Gy/min for both geriatric (&gt;15 years) and juvenile (10-14 months) cohorts. Samples of 2.5 ml peripheral blood (PAXgene tube) were collected from each NHP −2 week and −24 hr. prior to irradiation and 4 hr., 24 hr., 36 hr. post radiation, and on days 2, 3, 5, and 7 for a total of 9 blood draws per animal. Samples (0.5 ml) were also obtained in EDTA tubes to determine WBC differentials. 
         [0095]    NHP Fractionated Dose Testing: 
         [0096]    Two NHP models were developed to compare NHP gene response to human gene response for fractionated dose radiotherapy models. 
         [0097]    NHP Fractionated Dose Models: 
         [0098]    Blood (2.5 ml) was collected from 6 female and 6 male rhesus NHP into PAXgene tubes. The NHP were irradiated in vivo to parallel the 4 human in vivo test protocols as described below. For Study 1: Twelve (12) NHPs were exposed to 1.5 Gy twice per day (dose rate 0.6-0.8 Gy/min.) for 4 days at the same time each day. The blood samples were collected within 24 hr. prior to irradiation and 24 hrs. after each daily exposure (6 draws). For Study 2: Twelve (12) NHPs were exposed to 1.2 Gy (dose rate 0.6-0.8 Gy/min.) 3 times per day at the same time each day for 4-days. Blood samples were collected prior to irradiation and 24 hr. following each exposure (prior to the next exposure) for a total of 6 draws. The NHPs were irradiated by LINAC. At the time of sample collection, a complete differential white cell count was conducted. 
         [0099]    Human Fractionated Dose Models: 
         [0100]    Four human in vivo models were co-developed with Mayo Clinic, City of Hope and Stanford to provide blood samples from humans undergoing whole body and fractional radiation. 
         [0101]    Model 1—Bone Marrow Transplant Patients (BMT): Radiation dose is 1.65 to 2 Gy twice daily for 3 to 4 days. Samples are taken prior to and 24 hr. after daily irradiations. The last draw is on Day-7; 7 days after the first dose. (4-6 samples/Series). 
         [0102]    Model 2—Bone Marrow Transplant Patients (BMT): Radiation dose is 1.2 Gy three times daily for 4 days. Samples are taken prior to and 24 hr. after irradiation daily irradiations. The last draw is on Day-3 or 4; 3 or 4 days after the first dose. (5-7 samples/Series). 
         [0103]    Model 3—Bone Marrow Transplant Patients (BMT): Radiation dose is a single fraction related to models 1 and 2. Samples are taken prior to and every 24 hr. after irradiation. The last draw is on Day-6; 6 days after the first dose. (6-7 samples/Series). 
         [0104]    Model 4—X-Ray Therapy (XRT) Patients (&gt;7% bone marrow exposure): Radiation dose is 2-8 Gy each day for multiple days. Samples are taken prior to and 24 hr. after irradiation. The last draw is taken 7 days after the last exposure. 
         [0000]    
       
         
               
             
               
             
           
               
                 TABLE 5 
               
               
                   
               
               
                 Nucleotide Sequences of Biodosimetry Biomarker Genes 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                 CR2 (SEQ ID NO: 1; GenBank NM_001006658.2). 
               
               
                 ATTTAAGGGCCCGCCTCTCCTGGCTCACAGCTGCTTGCTGCTCCAGCCTTGCCCTCCC 
               
               
                 AGAGCTGCCGGACGCTCGCGGGTCTCGGAACGCATCCCGCCGCGGGGGCTTCGGCC 
               
               
                 GTGGCATGGGCGCCGCGGGCCTGCTCGGGGTTTTCTTGGCTCTCGTCGCACCGGGGG 
               
               
                 TCCTCGGGATTTCTTGTGGCTCTCCTCCGCCTATCCTAAATGGCCGGATTAGTTATTA 
               
               
                 TTCTACCCCCATTGCTGTTGGTACCGTGATAAGGTACAGTTGTTCAGGTACCTTCCGC 
               
               
                 CTCATTGGAGAAAAAAGTCTATTATGCATAACTAAAGACAAAGTGGATGGAACCTG 
               
               
                 GGATAAACCTGCTCCTAAATGTGAATATTTCAATAAATATTCTTCTTGCCCTGAGCCC 
               
               
                 ATAGTACCAGGAGGATACAAAATTAGAGGCTCTACACCCTACAGACATGGTGATTC 
               
               
                 TGTGACATTTGCCTGTAAAACCAACTTCTCCATGAACGGAAACAAGTCTGTTTGGTG 
               
               
                 TCAAGCAAATAATATGTGGGGGCCGACACGACTACCAACCTGTGTAAGTGTTTTCCC 
               
               
                 TCTCGAGTGTCCAGCACTTCCTATGATCCACAATGGACATCACACAAGTGAGAATGT 
               
               
                 TGGCTCCATTGCTCCAGGATTGTCTGTGACTTACAGCTGTGAATCTGGTTACTTGCTT 
               
               
                 GTTGGAGAAAAGATCATTAACTGTTTGTCTTCGGGAAAATGGAGTGCTGTCCCCCCC 
               
               
                 ACATGTGAAGAGGCACGCTGTAAATCTCTAGGACGATTTCCCAATGGGAAGGTAAA 
               
               
                 GGAGCCTCCAATTCTCCGGGTTGGTGTAACTGCAAACTTTTTCTGTGATGAAGGGTA 
               
               
                 TCGACTGCAAGGCCCACCTTCTAGTCGGTGTGTAATTGCTGGACAGGGAGTTGCTTG 
               
               
                 GACCAAAATGCCAGTATGTGAAGAAATTTTTTGCCCATCACCTCCCCCTATTCTCAA 
               
               
                 TGGAAGACATATAGGCAACTCACTAGCAAATGTCTCATATGGAAGCATAGTCACTTA 
               
               
                 CACTTGTGACCCGGACCCAGAGGAAGGAGTGAACTTCATCCTTATTGGAGAGAGCA 
               
               
                 CTCTCCGTTGTACAGTTGATAGTCAGAAGACTGGGACCTGGAGTGGCCCTGCCCCAC 
               
               
                 GCTGTGAACTTTCTACTTCTGCGGTTCAGTGTCCACATCCCCAGATCCTAAGAGGCC 
               
               
                 GAATGGTATCTGGGCAGAAAGATCGATATACCTATAACGACACTGTGATATTTGCTT 
               
               
                 GCATGTTTGGCTTCACCTTGAAGGGCAGCAAGCAAATCCGATGCAATGCCCAAGGC 
               
               
                 ACATGGGAGCCATCTGCACCAGTCTGTGAAAAGGAATGCCAGGCCCCTCCTAACAT 
               
               
                 CCTCAATGGGCAAAAGGAAGATAGACACATGGTCCGCTTTGACCCTGGAACATCTA 
               
               
                 TAAAATATAGCTGTAACCCTGGCTATGTGCTGGTGGGAGAAGAATCCATACAGTGTA 
               
               
                 CCTCTGAGGGGGTGTGGACACCCCCTGTACCCCAATGCAAAGTGGCAGCGTGTGAA 
               
               
                 GCTACAGGAAGGCAACTCTTGACAAAACCCCAGCACCAATTTGTTAGACCAGATGT 
               
               
                 CAACTCTTCTTGTGGTGAAGGGTACAAGTTAAGTGGGAGTGTTTATCAGGAGTGTCA 
               
               
                 AGGCACAATTCCTTGGTTTATGGAGATTCGTCTTTGTAAAGAAATCACCTGCCCACC 
               
               
                 ACCCCCTGTTATCTACAATGGGGCACACACCGGGAGTTCCTTAGAAGATTTTCCATA 
               
               
                 TGGAACCACGGTCACTTACACATGTAACCCTGGGCCAGAAAGAGGAGTGGAATTCA 
               
               
                 GCCTCATTGGAGAGAGCACCATCCGTTGTACAAGCAATGATCAAGAAAGAGGCACC 
               
               
                 TGGAGTGGCCCTGCTCCCCTGTGTAAACTTTCCCTCCTTGCTGTCCAGTGCTCACATG 
               
               
                 TCCATATTGCAAATGGATACAAGATATCTGGCAAGGAAGCCCCATATTTCTACAATG 
               
               
                 ACACTGTGACATTCAAGTGTTATAGTGGATTTACTTTGAAGGGCAGTAGTCAGATTC 
               
               
                 GTTGCAAAGCTGATAACACCTGGGATCCTGAAATACCAGTTTGTGAAAAAGGCTGC 
               
               
                 CAGTCACCTCCTGGGCTCCACCATGGTCGTCATACAGGTGGAAATACGGTCTTCTTT 
               
               
                 GTCTCTGGGATGACTGTAGACTACACTTGTGACCCTGGCTATTTGCTTGTGGGAAAC 
               
               
                 AAATCCATTCACTGTATGCCTTCAGGAAATTGGAGTCCTTCTGCCCCACGGTGTGAA 
               
               
                 GAAACATGCCAGCATGTGAGACAGAGTCTTCAAGAACTTCCAGCTGGTTCACGTGTG 
               
               
                 GAGCTAGTTAATACGTCCTGCCAAGATGGGTACCAGTTGACTGGACATGCTTATCAG 
               
               
                 ATGTGTCAAGATGCTGAAAATGGAATTTGGTTCAAAAAGATTCCACTTTGTAAAGTT 
               
               
                 ATTCACTGTCACCCTCCACCAGTGATTGTCAATGGGAAGCACACAGGCATGATGGCA 
               
               
                 GAAAACTTTCTATATGGAAATGAAGTCTCTTATGAATGTGACCAAGGATTCTATCTC 
               
               
                 CTGGGAGAGAAAAAATTGCAGTGCAGAAGTGATTCTAAAGGACATGGATCTTGGAG 
               
               
                 CGGGCCTTCCCCACAGTGCTTACGATCTCCTCCTGTGACTCGCTGCCCTAATCCAGA 
               
               
                 AGTCAAACATGGGTACAAGCTCAATAAAACACATTCTGCATATTCCCACAATGACAT 
               
               
                 AGTGTATGTTGACTGCAATCCTGGCTTCATCATGAATGGTAGTCGCGTGATTAGGTG 
               
               
                 TCATACTGATAACACATGGGTGCCAGGTGTGCCAACTTGTATCAAAAAAGCCTTCAT 
               
               
                 AGGGTGTCCACCTCCGCCTAAGACCCCTAACGGGAACCATACTGGTGGAAACATAG 
               
               
                 CTCGATTTTCTCCTGGAATGTCAATCCTGTACAGCTGTGACCAAGGCTACCTGCTGGT 
               
               
                 GGGAGAGGCACTCCTTCTTTGCACACATGAGGGAACCTGGAGCCAACCTGCCCCTC 
               
               
                 ATTGTAAAGAGGTAAACTGTAGCTCACCAGCAGATATGGATGGAATCCAGAAAGGG 
               
               
                 CTGGAACCAAGGAAAATGTATCAGTATGGAGCTGTTGTAACTCTGGAGTGTGAAGA 
               
               
                 TGGGTATATGCTGGAAGGCAGTCCCCAGAGCCAGTGCCAATCGGATCACCAATGGA 
               
               
                 ACCCTCCCCTGGCGGTTTGCAGATCCCGTTCACTTGCTCCTGTCCTTTGTGGTATTGC 
               
               
                 TGCAGGTTTGATACTTCTTACCTTCTTGATTGTCATTACCTTATACGTGATATCAAAA 
               
               
                 CACAGAGCACGCAATTATTATACAGATACAAGCCAGAAAGAAGCTTTTCATTTAGA 
               
               
                 AGCACGAGAAGTATATTCTGTTGATCCATACAACCCAGCCAGCTGATCAGAAGACA 
               
               
                 AACTGGTGTGTGCCTCATTGCTTGGAATTCAGCGGAATATTGATTAGAAAGAAACTG 
               
               
                 CTCTAATATCAGCAAGTCTCTTTATATGGCCTCAAGATCAATGAAATGATGTCATAA 
               
               
                 GCGATCACTTCCTATATGCACTTATTCTCAAGAAGAACATCTTTATGGTAAAGATGG 
               
               
                 GAGCCCAGTTTCACTGCCATATACTCTTCAAGGACTTTCTGAAGCCTCACTTATGAG 
               
               
                 ATGCCTGAAGCCAGGCCATGGCTATAAACAATTACATGGCTCTAAAAAGTTTTGCCC 
               
               
                 TTTTTAAGGAAGGCACTAAAAAGAGCTGTCCTGGTATCTAGACCCATCTTCTTTTTG 
               
               
                 AAATCAGCATACTCAATGTTACTATCTGCTTTTGGTTATAATGTGTTTTTAATTATCT 
               
               
                 AAAGTATGAAGCATTTTCTGGGGTTATGATGGCTTTACCTTTATTAGGAAGTATGGT 
               
               
                 TTTATTTTGATAGTAGCTTCCTCCTCTGGTGGTGTTAATCATTTCATTTTTACCCTTAC 
               
               
                 TTGGTTTGAGTTTCTCTCACATTACTGTATATACTTTGCCTTTCCATAATCACTCAGTG 
               
               
                 ATTGCAATTTGCACAAGTTTTTTTAAATTATGGGAATCAAGATTTAATCCTAGAGATT 
               
               
                 TGGTGTACAATTCAGGCTTTGGATGTTTCTTTAGCAGTTTTGTGATAAGTTCTAGTTG 
               
               
                 CTTGTAAAATTTCACTTAATAATGTGTACATTAGTCATTCAATAAATTGTAATTGTAA 
               
               
                 AGAAAACATACAAAAAAAAAAAAAAAA 
               
               
                   
               
               
                 DHRS4L1 (SEQ ID NO: 2; GenBank NM_001277864.1). 
               
               
                 AGTCGGGCAGCTCTCCGGGCCGGCGTGGGAGCCCGCGCTCCAAAGCCCGGTGGGGG 
               
               
                 GAGGGGCGCTCACGCAACCGCCACTGTCTGGAGCGGGCTCGCCTCTGCGGCGGCAC 
               
               
                 TCACCGCCCGGGCTTTACTGAAGCGGAGTCTAGCATGTGCGGCTGCTCCACAGCGGT 
               
               
                 GTGGGTGGCGGCGGCTCCTCTGCAGCAGCCTCGGCAGTAGGGGTCACGGTGGCCAA 
               
               
                 GCCCACCGTGGAGCTCATCTGAGAGTTGTAAGGTACGGGACTGCCTCGGTCTTTGGG 
               
               
                 ACGCCCCGTCTGGTAGCATCCCAGATCCAGCACGTTCCTTCCGGCCCTGCACCCCGG 
               
               
                 CCCGGTGCCTCACACCCCGCTACCCCATGCATCCAGACTCTAAGGCAGCCCCTGCAT 
               
               
                 CTCAGTCCTGACATCGCTGTCCCTGGAGCATCCTCCGCTGGAGCTGGAGCTTGACAG 
               
               
                 GATCGGCTTCGCCGTCGCCCAGCGTCTGGCCCAAGACGGGGCCCACGTGGTAGTCA 
               
               
                 GCCGCCGGAAGCAGCAGAATGTGGACCAGGCAGTGGCCACGCTGCAGGGGGAGGG 
               
               
                 GCTGAGCATGACGGGCACTGTGTGCCATGTGGGGAAGATGAAGGACTGGGAGCGGC 
               
               
                 TGGTGGCCACAGTGAGCTGCAGGGAAATGGGCACAGAGCCAGGAGGTGGAAAAGG 
               
               
                 GAGCCAGCCTGAGCCTCCTTCCCTGCTTTCCTGGACAGCATTGGGCTTCAGTCCTTAC 
               
               
                 AATGTCAGTAAAACAGCCTTGCTGGGCCTCAACAAGACCTTGGCCATAGAGCTGGC 
               
               
                 CCCAAGGAACATTAGGGTGAACTGCCTAGCACCTGGACTTATCAAGACTAGCTTCAG 
               
               
                 CAGGATGCTCTGGATGGACAAGGAAAAAGAGGAAAGCATGAAAGAAACCCTGCGG 
               
               
                 ATAAGAAGGTTAGGCGAGCCAGAGGATTCTCTTGGCATCGTGTCTTTCCTGTGCTCT 
               
               
                 GAAGATGCCAGCTACCTCACTGGGGAAACAGTGATGGTGGGTGGAGGAACCCCGTC 
               
               
                 CCGCCTCTGAGGACCCGGAGACAGCCCACAGGCCAGAGTTGGGCTCTAGCTCCTGG 
               
               
                 TGCTGTTCCTGCATTCACCCACTGGCCTTTCCCACCTCTGCTCACCTTACTGTTCACC 
               
               
                 TCATCAAATCAGTTCTGCCCTGTGAAAAGATCCAGCCTTCCCTGCCGTCAAGGTGGT 
               
               
                 GTCTTACTCGGGATTCCTGCTGTTGTTGTGGCCTTGGGTAAAGGCCTCCCCTGAGAA 
               
               
                 CACAGGACAGGCCTGCTGACAAGGCTGAGTCTACCTTGGCAAAGACCAAGATATTT 
               
               
                 TTTGCCCAGGCCACTGGGGAATTTGAGGGGAGATGAGAGAGAAGGAAGCTGGAGTG 
               
               
                 GAAGGAGCAGAGTTGCAAATTAACAACTTGCAAATGAGGTGCAAATAAAATGCAGA 
               
               
                 TGATTGCGCGGCTTTGAATCGAAAAAAAAAAA 
               
               
                   
               
               
                 HCK (SEQ ID NO: 3; GenBank NM_001172129.1). 
               
               
                 GGAGTTAGCCTCGCTCAGGGCGCGGCTAAGGCGCCCAGATGGCCTGCGGGCGCCAC 
               
               
                 CACGTCCCTGGTCCCAGCTCGGGAGCACATCAGAGGCTTAGAGGCGAGTGGGAAGG 
               
               
                 GACTCAGACAGTGCAGGACGAGAAACGCCCGCGGCACCAAAGCCCCTCAGAGCGTC 
               
               
                 GCCCCCGCCTCTAGTTCTAGAAAGTCAGTTTCCCGGCACTGGCACCCCGGAACCTCA 
               
               
                 GGGGCTGCCGAGCTGGGGGGGCGCTCAAGCTGCGAGGATCCGGGCTGCCCGCGAGA 
               
               
                 CGAGGAGCGGGCGCCCAGGATGGGGTGCATGAAGTCCAAGTTCCTCCAGGTCGGAG 
               
               
                 GCAATACATTCTCAAAAACTGAAACCAGCGCCAGCCCACACTGTCCTGTGTACGTGC 
               
               
                 CGGATCCCACATCCACCATCAAGCCGGGGCCTAATAGCCACAACAGCAACACACCA 
               
               
                 GGAATCAGGGAGGCAGGCTCTGAGGACATCATCGTGGTTGCCCTGTATGATTACGA 
               
               
                 GGCCATTCACCACGAAGACCTCAGCTTCCAGAAGGGGGACCAGATGGTGGTCCTAG 
               
               
                 AGGAATCCGGGGAGTGGTGGAAGGCTCGATCCCTGGCCACCCGGAAGGAGGGCTAC 
               
               
                 ATCCCAAGCAACTATGTCGCCCGCGTTGACTCTCTGGAGACAGAGGAGTGGTTTTTC 
               
               
                 AAGGGCATCAGCCGGAAGGACGCAGAGCGCCAACTGCTGGCTCCCGGCAACATGCT 
               
               
                 GGGCTCCTTCATGATCCGGGATAGCGAGACCACTAAAGGAAGCTACTCTTTGTCCGT 
               
               
                 GCGAGACTACGACCCTCGGCAGGGAGATACCGTGAAACATTACAAGATCCGGACCC 
               
               
                 TGGACAACGGGGGCTTCTACATATCCCCCCGAAGCACCTTCAGCACTCTGCAGGAGC 
               
               
                 TGGTGGACCACTACAAGAAGGGGAACGACGGGCTCTGCCAGAAACTGTCGGTGCCC 
               
               
                 TGCATGTCTTCCAAGCCCCAGAAGCCTTGGGAGAAAGATGCCTGGGAGATCCCTCG 
               
               
                 GGAATCCCTCAAGCTGGAGAAGAAACTTGGAGCTGGGCAGTTTGGGGAAGTCTGGA 
               
               
                 TGGCCACCTACAACAAGCACACCAAGGTGGCAGTGAAGACGATGAAGCCAGGGAG 
               
               
                 CATGTCGGTGGAGGCCTTCCTGGCAGAGGCCAACGTGATGAAAACTCTGCAGCATG 
               
               
                 ACAAGCTGGTCAAACTTCATGCGGTGGTCACCAAGGAGCCCATCTACATCATCACG 
               
               
                 GAGTTCATGGCCAAAGGAAGCTTGCTGGACTTTCTGAAAAGTGATGAGGGCAGCAA 
               
               
                 GCAGCCATTGCCAAAACTCATTGACTTCTCAGCCCAGATTGCAGAAGGCATGGCCTT 
               
               
                 CATCGAGCAGAGGAACTACATCCACCGAGACCTCCGAGCTGCCAACATCTTGGTCTC 
               
               
                 TGCATCCCTGGTGTGTAAGATTGCTGACTTTGGCCTGGCCCGGGTCATTGAGGACAA 
               
               
                 CGAGTACACGGCTCGGGAAGGGGCCAAGTTCCCCATCAAGTGGACAGCTCCTGAAG 
               
               
                 CCATCAACTTTGGCTCCTTCACCATCAAGTCAGACGTCTGGTCCTTTGGTATCCTGCT 
               
               
                 GATGGAGATCGTCACCTACGGCCGGATCCCTTACCCAGGGATGTCAAACCCTGAAG 
               
               
                 TGATCCGAGCTCTGGAGCGTGGATACCGGATGCCTCGCCCAGAGAACTGCCCAGAG 
               
               
                 GAGCTCTACAACATCATGATGCGCTGCTGGAAAAACCGTCCGGAGGAGCGGCCGAC 
               
               
                 CTTCGAATACATCCAGAGTGTGCTGGATGACTTCTACACGGCCACAGAGAGCCAGTA 
               
               
                 CCAACAGCAGCCATGATAGGGAGGACCAGGGCAGGGCCAGGGGGTGCCCAGGTGG 
               
               
                 TGGCTGCAAGGTGGCTCCAGCACCATCCGCCAGGGCCCACACCCCCTTCCTACTCCC 
               
               
                 AGACACCCACCCTCGCTTCAGCCACAGTTTCCTCATCTGTCCAGTGGGTAGGTTGGA 
               
               
                 CTGGAAAATCTCTTTTTGACTCTTGCAATCCACAATCTGACATTCTCAGGAAGCCCCC 
               
               
                 AAGTTGATATTTCTATTTCCTGGAATGGTTGGATTTTAGTTACAGCTGTGATTTGGAA 
               
               
                 GGGAAACTTTCAAAATAGTGAAATGAATATTTAAATAAAAGATATAAATGCCAAAG 
               
               
                 TCTTTACCAAAAAAAAAAAAAAAAA 
               
               
                   
               
               
                 IL1RAP (SEQ ID NO: 4; GenBank NM_002182.3). 
               
               
                 AAAGGGGGAAAAGAAAGTGCGGCGGAAAGTAAGAGGCTCACTGGGGAAGACTGCC 
               
               
                 GGGATCCAGGTCTCCGGGGTCCGCTTTGGCCAGAGGCGCGGAAGGAAGCAGTGCCC 
               
               
                 GGCGACACTGCACCCATCCCGGCTGCTTTTGCTGCGCCCTCTCAGCTTCCCAAGAAA 
               
               
                 GGCATCGTCATGTGATCATCACCTAAGAACTAGAACATCAGCAGGCCCTAGAAGCC 
               
               
                 TCACTCTTGCCCCTCCCTTTAATATCTCAAAGGATGACACTTCTGTGGTGTGTAGTGA 
               
               
                 GTCTCTACTTTTATGGAATCCTGCAAAGTGATGCCTCAGAACGCTGCGATGACTGGG 
               
               
                 GACTAGACACCATGAGGCAAATCCAAGTGTTTGAAGATGAGCCAGCTCGCATCAAG 
               
               
                 TGCCCACTCTTTGAACACTTCTTGAAATTCAACTACAGCACAGCCCATTCAGCTGGC 
               
               
                 CTTACTCTGATCTGGTATTGGACTAGGCAGGACCGGGACCTTGAGGAGCCAATTAAC 
               
               
                 TTCCGCCTCCCCGAGAACCGCATTAGTAAGGAGAAAGATGTGCTGTGGTTCCGGCCC 
               
               
                 ACTCTCCTCAATGACACTGGCAACTATACCTGCATGTTAAGGAACACTACATATTGC 
               
               
                 AGCAAAGTTGCATTTCCCTTGGAAGTTGTTCAAAAAGACAGCTGTTTCAATTCCCCC 
               
               
                 ATGAAACTCCCAGTGCATAAACTGTATATAGAATATGGCATTCAGAGGATCACTTGT 
               
               
                 CCAAATGTAGATGGATATTTTCCTTCCAGTGTCAAACCGACTATCACTTGGTATATG 
               
               
                 GGCTGTTATAAAATACAGAATTTTAATAATGTAATACCCGAAGGTATGAACTTGAGT 
               
               
                 TTCCTCATTGCCTTAATTTCAAATAATGGAAATTACACATGTGTTGTTACATATCCAG 
               
               
                 AAAATGGACGTACGTTTCATCTCACCAGGACTCTGACTGTAAAGGTAGTAGGCTCTC 
               
               
                 CAAAAAATGCAGTGCCCCCTGTGATCCATTCACCTAATGATCATGTGGTCTATGAGA 
               
               
                 AAGAACCAGGAGAGGAGCTACTCATTCCCTGTACGGTCTATTTTAGTTTTCTGATGG 
               
               
                 ATTCTCGCAATGAGGTTTGGTGGACCATTGATGGAAAAAAACCTGATGACATCACTA 
               
               
                 TTGATGTCACCATTAACGAAAGTATAAGTCATAGTAGAACAGAAGATGAAACAAGA 
               
               
                 ACTCAGATTTTGAGCATCAAGAAAGTTACCTCTGAGGATCTCAAGCGCAGCTATGTC 
               
               
                 TGTCATGCTAGAAGTGCCAAAGGCGAAGTTGCCAAAGCAGCCAAGGTGAAGCAGAA 
               
               
                 AGTGCCAGCTCCAAGATACACAGTGGAACTGGCTTGTGGTTTTGGAGCCACAGTCCT 
               
               
                 GCTAGTGGTGATTCTCATTGTTGTTTACCATGTTTACTGGCTAGAGATGGTCCTATTT 
               
               
                 TACCGGGCTCATTTTGGAACAGATGAAACCATTTTAGATGGAAAAGAGTATGATATT 
               
               
                 TATGTATCCTATGCAAGGAATGCGGAAGAAGAAGAATTTGTATTACTGACCCTCCGT 
               
               
                 GGAGTTTTGGAGAATGAATTTGGATACAAGCTGTGCATCTTTGACCGAGACAGTCTG 
               
               
                 CCTGGGGGAATTGTCACAGATGAGACTTTGAGCTTCATTCAGAAAAGCAGACGCCTC 
               
               
                 CTGGTTGTTCTAAGCCCCAACTACGTGCTCCAGGGAACCCAAGCCCTCCTGGAGCTC 
               
               
                 AAGGCTGGCCTAGAAAATATGGCCTCTCGGGGCAACATCAACGTCATTTTAGTACAG 
               
               
                 TACAAAGCTGTGAAGGAAACGAAGGTGAAAGAGCTGAAGAGGGCTAAGACGGTGC 
               
               
                 TCACGGTCATTAAATGGAAAGGGGAAAAATCCAAGTATCCACAGGGCAGGTTCTGG 
               
               
                 AAGCAGCTGCAGGTGGCCATGCCAGTGAAGAAAAGTCCCAGGCGGTCTAGCAGTGA 
               
               
                 TGAGCAGGGCCTCTCGTATTCATCTTTGAAAAATGTATGAAAGGAATAATGAAAAG 
               
               
                 GGTAAAAAGAACAAGGGGTGCTCCAGGAAGAAAGAGTCCCCCCAGTCTTCATTCGC 
               
               
                 AGTTTATGGTTTCATAGGCAAAAATAATGGTCTAAGCCTCCCAATAGGGATAAATTT 
               
               
                 AGGGTGACTGTGTGGCTGACTATTCTGCTTCCTCAGGCAACACTAAAGTTTAGAAAG 
               
               
                 ATATCATCAACGTTCTGTCACCAGTCTCTGATGCCACTATGTTCTTTGCAGGCAAAG 
               
               
                 ACTTGTTCAATGCGAATTTCCCCTTCTACATTGTCTATCCCTGTTTTTATATGTCTCCA 
               
               
                 TTCTTTTTAAAATCTTAACATATGGAGCAGCCTTTCCTATGAATTTAAATATGCCTTT 
               
               
                 AAAATAAGTCACTGTTGACAGGGTCATGAGTTTCCGAGTATAGTTTTCTTTTTATCTT 
               
               
                 ATTTTTACTCGTCCGTTGAAAAGATAATCAAGGCCTACATTTTAGCTGAGGATAATG 
               
               
                 AACTTTTTTCCTCATTCGGCTGTATAATACATAACCACAGCAAGACTGACATCCACTT 
               
               
                 AGGATGATACAAAGCAGTGTAACTGAAAATGTTTCTTTTAATTGATTTAAAGGACTT 
               
               
                 GTCTTCTATACCACCCTTGTCCTCATCTCAGGTAATTTATGAAATCTATGTAAACTTG 
               
               
                 AAAAATATTTCTTAATTTTTGTTTTTGCTCCAGTCAATTCCTGATTATCCACAGGTCA 
               
               
                 ACCCACATTTTTTCATTCCTTCTCCCTATCTGCTTATATCGCATTGCTCATTTAGAGTT 
               
               
                 TGCAGGAGGCTCCATACTAGGTTCAGTCTGAAAGAAATCTCCTAATGGTGCTATAGA 
               
               
                 GAGGGAGGTAACAGAAAGACTCTTTTAGGGCATTTTTCTGACTCATGAAAAGAGCA 
               
               
                 CAGAAAAGGATGTTTGGCAATTTGTCTTTTAAGTCTTAACCTTGCTAATGTGAATACT 
               
               
                 GGGAAAGTGATTTTTTCTCACTCGTTTTTGTTGCTCCATTGTAAAGGGCGGAGGTCA 
               
               
                 GTCTTAGTGGCCTTGAGAGTTGCTTTTGGCATTAATATTCTAAGAGAATTAACTGTAT 
               
               
                 TTCCTGTCACCTATTCACTAGTGCAGGAAATATACTTGCTCCAAATAAGTCAGTATG 
               
               
                 AGAAGTCACTGTCAATGAAAGTTGTTTTGTTTGTTTTCAGTAATATTTTGCTGTTTTT 
               
               
                 AAGACTTGGAAAACTAAGTGCAGAGTTTACAGAGTGGTAAATATCTATGTTACATGT 
               
               
                 AGATTATACATATATATACACACGTGTATATGAGATATATATCTTATATCTCCACAA 
               
               
                 ACACAAATTATATATATACATATCCACACACATACATTACATATATCTGTGTATATA 
               
               
                 AATCCACATGCACATGAAATATATATATATATATAATTTGTGTGTGTGTATGTGTAT 
               
               
                 GTATATGACTTTAAATAGCTATGGGTACAATATTAAAAACCACTGGAACTCTTGTCC 
               
               
                 AGTTTTTAAATTATGTTTTTACTGGAATGTTTTTGTGTCAGTGTTTTCTGTACATATTA 
               
               
                 TTTGTTAATTCACAGCTCACAGAGTGATAGTTGTCATAGTTCTTGCCTTCCCTAAGTT 
               
               
                 TATATAAATAACTTAAGTATTGCTACAGTTTATCTAGGTTGCAGTGGCATCTGCTGTG 
               
               
                 CACAGAGCTTCCATGGTCACTGCTAAGCAGTAGCCAGCCATCGGGCATTAATTGATT 
               
               
                 TCCTACTATATTCCCAGCAGACACATTTAGAAACTAAGCTATGTTAACCTCAGTGCT 
               
               
                 CAACTATTTGAACTGTTGAGTGATAAAGGAAACAAATATAACTGTAAATGAATCTTG 
               
               
                 GTATCCTGTGAAACAGAATAATTCGTAATTTAAGAAAGCCCTTATCCCGGTAACATG 
               
               
                 AATGTTGATGAACAAATGTAAAATTATATCCTATATTTAAGTACCCATAATAAATCA 
               
               
                 TTTCCCTCTATAAGTGTTATTGATTATTTTAAATTGAAAAAAGTTTCACTTGGATGAA 
               
               
                 AAAAGTAGAAAAGTAGGTCATTCTTGGATCTACTTTTTTTTAGCCTTATTAATATTTT 
               
               
                 TCCCTATTAGAAACCACAATTACTCCCTCTATTAACCCTTCACTTACTAGACCAGAA 
               
               
                 AAGAACTTATTCCAGATAAGCTTTGAATATCAATTCTTACATAAACTTTAGGCAAAC 
               
               
                 AGGGAATAGTCTAGTCACCAAAGGACCATTCTCTTGCCAATGCTGCATTCCTTTTGC 
               
               
                 ACTTTTGGATTCCATATTTATCCCAAATGCTGTTGGGCACCCCTAGAAATACCTTGAT 
               
               
                 GTTTTTTCTATTTATATGCCTGCCTTTGGTACTTAATTTTACAAATGCTGTAATATAA 
               
               
                 AGCATATCAAGTTTATGTGATACGTATCATTGCAAGAGAATTTGTTTCAAGATTTTTT 
               
               
                 TTTAATGTTCCAGAAGATGGCCAATAGAGAACATTCAAGGGAAATGGGGAAACATA 
               
               
                 ATTTAGAGAACAAGAACAAACCATGTCTCAAATTTTTTTAAAAAAAATTAATGGTTT 
               
               
                 TAAATATATGCTATAGGGACGTTCCATGCCCAGGTTAACAAAGAACTGTGATATATA 
               
               
                 GAGTGTCTAATTACAAAATCATATACGATTTATTTAATTCTCTTCTGTATTGTAACTT 
               
               
                 AGATGATTCCCAAGGACTCTAATAAAAAATCACTTCATTGTATTTGGAAACAAAAAC 
               
               
                 ATCATTCATTAATTACTTATTTTCTTTCCATAGGTTTTAATATTTTGAGAGTGTCTTTT 
               
               
                 TTATTTCATTCATGAACTTTTGTATTTTTCATTTTTCATTTGATTTGTAAATTTACTTAT 
               
               
                 GTTAAAAATAAACCATTTATTTTCAGCTTTGAATTTTAAAAAAAAAAAAAAAAAA 
               
               
                   
               
               
                 LYRM4 (SEQ ID NO: 5; GenBank NM_020408.5). 
               
               
                 GAGCCCTGCCTGCGCCCGCCCCCGAAGCGGCGCGGGACGCCTGGCGCCGTCCGCGA 
               
               
                 TCCGCAGGGCTGCCCGCTTAGGCTTAGGCCCGGCCCGCTGGCAAAGCCGAGCCGCA 
               
               
                 GCATTTTATTTCGTTCGTGGTTTCCGCACAGGCTGGAGTTTCGTGGGTTGGGTCGTAC 
               
               
                 TTGGGACCTCGGCGAAGAGGACCCGTTTATTTTTTTTTCTTTCCAAAATGGCAGCCTC 
               
               
                 CAGTCGCGCACAAGTGTTATCTCTGTACCGGGCGATGCTGAGAGAGAGCAAGCGTTT 
               
               
                 CAGCGCCTACAATTACAGAACATATGCTGTCAGGAGGATAAGAGATGCCTTCAGAG 
               
               
                 AAAATAAAAATGTAAAGGATCCTGTAGAAATTCAAACCCTAGTGAATAAAGCCAAG 
               
               
                 AGAGACCTTGGAGTAATTCGTCGACAGGTCCACATTGGCCAACTGTATTCAACTGAC 
               
               
                 AAGCTGATCATTGAGAATCGAGACATGCCCAGGACCTAGCAAGCCGGGGACCAGCC 
               
               
                 ACCAGTGGCGGCCAGGGACCACCTTCAGCATCCACTCTCTGTTTGAGATGGGGGCTC 
               
               
                 CCAAAACCAGCTTACAATAGCCTTTTGCGCTGCCTGTCCTGTGGGAGCTGATAAACC 
               
               
                 AAGTCACATTTGCATTCTGTTGCAGGCTTAGTGAAAAAGGACTGCTGTCTTTCCTTG 
               
               
                 GTTCAAGTGTTAGAATGGAGAGCTGGAGTTCGTTCAGAATAGTGCTGTGTGTTACCA 
               
               
                 CGTCTCCCCTGCACCCCATTCCTACCTTGTAGCTCATGACCATTGTGTATAGCATTTC 
               
               
                 TACACTTTGTTTCTTGGTCCTTGGCAATAAAAAGAATGATCTCCCTGAGCCTTTGACC 
               
               
                 CCAGATAAACCCCTCCCAATTAATGCATTTTCATTTCCTACTGATACAAGGCCTGGA 
               
               
                 GAGGGCTGTTGGGGGCCCTCAGGGAGGGTTCAACTCTGAGACGAGAACTGCCTTGG 
               
               
                 TGAAGGCAAGTTCAAGCACCACTTGAGACTGGGGGCAGCATGGAGTAGGGCAGGGC 
               
               
                 TACGGGGATACACGGTGCACCCTGCAACTTATACCTGAGCCCAGTACAACAAAGGT 
               
               
                 GACGGGTGTGTAGGTACACACCCAGAGATGGAGCACTGCAGATCAGCAACCTCAGC 
               
               
                 CCCACCTGGGAATTTGCTGGAAATGCAGGCTCAAGCCCCTCCCCACACCTGGTGAAT 
               
               
                 GAGAGAGCCCCAGCCTGACCCAAGCCCAGGGCGACTCCCATACCCTGAAGCCTGGG 
               
               
                 GCATGCTGGGCAGCACCGGTGCCCAAATCTGGCTGGTGGACAGAAGCACCTGGAGA 
               
               
                 GTTGGAGAGCTTTTTAAAAAGACATCTCTCAGCACTTCCCTCTCTGCAGATTCTGACT 
               
               
                 CAGTAAGTGAGGGGTGAGGCACAGTCATTTTTCTCTATTCTGAAGCTCTCCCACTGT 
               
               
                 TTTCAATGTTTAACCAACTGGGGACCCCTGCTCTTTAAGTATATTACAGGTAATAAA 
               
               
                 GATATTGTTTGTATGCTTTTAAAAAAAAAAAAAAAAAA. 
               
               
                   
               
               
                 MYC (SEQ ID NO: 6; GenBank NM_002467). 
               
               
                 GACCCCCGAGCTGTGCTGCTCGCGGCCGCCACCGCCGGGCCCCGGCCGTCCCTGGCT 
               
               
                 CCCCTCCTGCCTCGAGAAGGGCAGGGCTTCTCAGAGGCTTGGCGGGAAAAAGAACG 
               
               
                 GAGGGAGGGATCGCGCTGAGTATAAAAGCCGGTTTTCGGGGCTTTATCTAACTCGCT 
               
               
                 GTAGTAATTCCAGCGAGAGGCAGAGGGAGCGAGCGGGCGGCCGGCTAGGGTGGAA 
               
               
                 GAGCCGGGCGAGCAGAGCTGCGCTGCGGGCGTCCTGGGAAGGGAGATCCGGAGCG 
               
               
                 AATAGGGGGCTTCGCCTCTGGCCCAGCCCTCCCGCTGATCCCCCAGCCAGCGGTCCG 
               
               
                 CAACCCTTGCCGCATCCACGAAACTTTGCCCATAGCAGCGGGCGGGCACTTTGCACT 
               
               
                 GGAACTTACAACACCCGAGCAAGGACGCGACTCTCCCGACGCGGGGAGGCTATTCT 
               
               
                 GCCCATTTGGGGACACTTCCCCGCCGCTGCCAGGACCCGCTTCTCTGAAAGGCTCTC 
               
               
                 CTTGCAGCTGCTTAGACGCTGGATTTTTTTCGGGTAGTGGAAAACCAGCAGCCTCCC 
               
               
                 GCGACGATGCCCCTCAACGTTAGCTTCACCAACAGGAACTATGACCTCGACTACGAC 
               
               
                 TCGGTGCAGCCGTATTTCTACTGCGACGAGGAGGAGAACTTCTACCAGCAGCAGCA 
               
               
                 GCAGAGCGAGCTGCAGCCCCCGGCGCCCAGCGAGGATATCTGGAAGAAATTCGAGC 
               
               
                 TGCTGCCCACCCCGCCCCTGTCCCCTAGCCGCCGCTCCGGGCTCTGCTCGCCCTCCTA 
               
               
                 CGTTGCGGTCACACCCTTCTCCCTTCGGGGAGACAACGACGGCGGTGGCGGGAGCTT 
               
               
                 CTCCACGGCCGACCAGCTGGAGATGGTGACCGAGCTGCTGGGAGGAGACATGGTGA 
               
               
                 ACCAGAGTTTCATCTGCGACCCGGACGACGAGACCTTCATCAAAAACATCATCATCC 
               
               
                 AGGACTGTATGTGGAGCGGCTTCTCGGCCGCCGCCAAGCTCGTCTCAGAGAAGCTG 
               
               
                 GCCTCCTACCAGGCTGCGCGCAAAGACAGCGGCAGCCCGAACCCCGCCCGCGGCCA 
               
               
                 CAGCGTCTGCTCCACCTCCAGCTTGTACCTGCAGGATCTGAGCGCCGCCGCCTCAGA 
               
               
                 GTGCATCGACCCCTCGGTGGTCTTCCCCTACCCTCTCAACGACAGCAGCTCGCCCAA 
               
               
                 GTCCTGCGCCTCGCAAGACTCCAGCGCCTTCTCTCCGTCCTCGGATTCTCTGCTCTCC 
               
               
                 TCGACGGAGTCCTCCCCGCAGGGCAGCCCCGAGCCCCTGGTGCTCCATGAGGAGAC 
               
               
                 ACCGCCCACCACCAGCAGCGACTCTGAGGAGGAACAAGAAGATGAGGAAGAAATC 
               
               
                 GATGTTGTTTCTGTGGAAAAGAGGCAGGCTCCTGGCAAAAGGTCAGAGTCTGGATC 
               
               
                 ACCTTCTGCTGGAGGCCACAGCAAACCTCCTCACAGCCCACTGGTCCTCAAGAGGTG 
               
               
                 CCACGTCTCCACACATCAGCACAACTACGCAGCGCCTCCCTCCACTCGGAAGGACTA 
               
               
                 TCCTGCTGCCAAGAGGGTCAAGTTGGACAGTGTCAGAGTCCTGAGACAGATCAGCA 
               
               
                 ACAACCGAAAATGCACCAGCCCCAGGTCCTCGGACACCGAGGAGAATGTCAAGAGG 
               
               
                 CGAACACACAACGTCTTGGAGCGCCAGAGGAGGAACGAGCTAAAACGGAGCTTTTT 
               
               
                 TGCCCTGCGTGACCAGATCCCGGAGTTGGAAAACAATGAAAAGGCCCCCAAGGTAG 
               
               
                 TTATCCTTAAAAAAGCCACAGCATACATCCTGTCCGTCCAAGCAGAGGAGCAAAAG 
               
               
                 CTCATTTCTGAAGAGGACTTGTTGCGGAAACGACGAGAACAGTTGAAACACAAACT 
               
               
                 TGAACAGCTACGGAACTCTTGTGCGTAAGGAAAAGTAAGGAAAACGATTCCTTCTA 
               
               
                 ACAGAAATGTCCTGAGCAATCACCTATGAACTTGTTTCAAATGCATGATCAAATGCA 
               
               
                 ACCTCACAACCTTGGCTGAGTCTTGAGACTGAAAGATTTAGCCATAATGTAAACTGC 
               
               
                 CTCAAATTGGACTTTGGGCATAAAAGAACTTTTTTATGCTTACCATCTTTTTTTTTTCT 
               
               
                 TTAACAGATTTGTATTTAAGAATTGTTTTTAAAAAATTTTAAGATTTACACAATGTTT 
               
               
                 CTCTGTAAATATTGCCATTAAATGTAAATAACTTTAATAAAACGTTTATAGCAGTTA 
               
               
                 CACAGAATTTCAATCCTAGTATATAGTACCTAGTATTATAGGTACTATAAACCCTAA 
               
               
                 TTTTTTTTATTTAAGTACATTTTGCTTTTTAAAGTTGATTTTTTTCTATTGTTTTTAGAA 
               
               
                 AAAATAAAATAACTGGCAAATATATCATTGAGCCAAATCTTAAAAAAAAAAAAAAA 
               
               
                   
               
               
                 TMEM63B (SEQ ID NO: 7; GenBank NM_018426.1). 
               
               
                 AACCCGGGGCTCCGAGCCGGAGCCGAGTCTGCGCCTGGGGGAGGACCATGCGGCAG 
               
               
                 TAGCAGCCATGCTGCCCTTTCTGCTGGCCACACTGGGCACCACAGCCCTCAACAACA 
               
               
                 GCAACCCCAAGGACTACTGCTACAGCGCCCGCATCCGCAGCACTGTCCTGCAGGGC 
               
               
                 CTGCCCTTTGGGGGCGTCCCCACCGTGCTGGCTCTCGACTTCATGTGCTTCCTTGCAC 
               
               
                 TGCTGTTCTTATTCTCTATCCTCCGGAAGGTGGCCTGGGACTATGGGCGGCTGGCCTT 
               
               
                 GGTGACAGATGCAGACAGGCTTCGGCGGCAGGAGAGGGACCGAGTGGAACAGGAA 
               
               
                 TATGTGGCTTCAGCTATGCACGGGGACAGCCATGACCGGTATGAGCGTCTCACCTCT 
               
               
                 GTCTCCAGCTCCGTTGACTTTGACCAAAGGGACAATGGTTTCTGTTCCTGGCTGACA 
               
               
                 GCCATCTTCAGGATAAAGGATGATGAGATCCGGGACAAATGTGGGGGCGATGCCGT 
               
               
                 GCACTACCTGTCCTTTCAGCGGCACATCATCGGGCTGCTGGTGGTTGTGGGCGTCCT 
               
               
                 CTCCGTAGGCATCGTGCTGCCTGTCAACTTCTCAGGGGACCTGCTGGAGAACAATGC 
               
               
                 CTACAGCTTTGGGAGAACCACCATTGCCAACTTGAAATCAGGGAACAACCTGCTATG 
               
               
                 GCTGCACACCTCCTTCGCCTTCCTGTATCTGCTGCTCACCGTCTACAGCATGCGTAGA 
               
               
                 CACACCTCCAAGATGCGCTACAAGGAGGATGATCTGGTGAAGCGGACCCTCTTCAT 
               
               
                 CAATGGAATCTCCAAATATGCAGAGTCAGAAAAGATCAAGAAGCATTTTGAGGAAG 
               
               
                 CCTACCCCAACTGCACAGTTCTCGAAGCCCGCCCGTGTTACAACGTGGCTCGCCTAA 
               
               
                 TGTTCCTCGATGCAGAGAGGAAGAAGGCCGAGCGGGGAAAGCTGTACTTCACAAAC 
               
               
                 CTCCAGAGCAAGGAGAACGTGCCTACCATGATCAACCCCAAGCCCTGTGGCCACCT 
               
               
                 CTGCTGCTGTGTGGTGCGAGGCTGTGAGCAGGTGGAGGCCATTGAGTACTACACAA 
               
               
                 AGCTGGAGCAGAAGCTGAAGGAAGACTACAAGCGGGAGAAGGAGAAGGTGAATGA 
               
               
                 GAAGCCTCTTGGCATGGCCTTTGTCACCTTCCACAATGAGACTATCACCGCCATCAT 
               
               
                 CCTGAAGGACTTCAACGTGTGTAAATGCCAGGGCTGCACCTGCCGTGGGGAGCCAC 
               
               
                 GCCCCTCATCCTGCAGCGAGTCCCTGCACATCTCCAACTGGACCGTGTCCTATGCCC 
               
               
                 CTGACCCTCAGAACATCTACTGGGAGCACCTCTCCATCCGAGGCTTCATCTGGTGGC 
               
               
                 TGCGCTGCCTGGTCATCAATGTCGTCCTCTTCATCCTCCTCTTCTTCCTCACCACTCC 
               
               
                 AGCCATCATCATCACCACCATGGACAAGTTCAACGTCACCAAGCCTGTGGAGTACCT 
               
               
                 CAACAACCCCATCATCACCCAGTTCTTCCCCACCCTGCTGCTGTGGTGCTTCTCGGCC 
               
               
                 CTCCTTCCCACCATCGTCTACTACTCAGCCTTCTTTGAAGCCCACTGGACACGCTCTG 
               
               
                 GGGAGAACAGGACAACCATGCACAAGTGCTACACTTTCCTCATCTTCATGGTGCTGC 
               
               
                 TCCTACCCTCGCTGGGACTGAGCAGCCTGGACCTCTTCTTCCGCTGGCTCTTTGATAA 
               
               
                 GAAATTCTTGGCTGAGGCAGCTATTCGGTTTGAGTGTGTGTTCCTGCCCGACAACGG 
               
               
                 CGCCTTCTTCGTGAACTACGTCATTGCCTCAGCCTTTATCGGCAACGCCATGGACCT 
               
               
                 GCTGCGCATCCCAGGCCTGCTCATGTACATGATCCGGCTCTGCCTGGCGCGCTCGGC 
               
               
                 CGCCGAGAGGCGCAACGTGAAGCGGCATCAGGCCTACGAGTTCCAGTTTGGCGCAG 
               
               
                 CCTACGCCTGGATGATGTGCGTCTTCACGGTGGTCATGACCTACAGTATCACCTGCC 
               
               
                 CCATCATCGTGCCCTTCGGGCTCATGTACATGCTGCTGAAGCACCTGGTAGACAGGT 
               
               
                 ACAATCTCTACTACGCCTACCTGCCGGCCAAGCTGGACAAGAAGATCCACTCGGGG 
               
               
                 GCTGTGAACCAGGTGGTGGCCGCGCCCATCCTCTGCCTCTTCTGGCTGCTCTTCTTTT 
               
               
                 CCACCATGCGCACGGGGTTCCTAGCTCCCACGTCTATGTTCACATTTGTGGTCCTGGT 
               
               
                 CATCACCATCGTCATCTGTCTCTGCCACGTCTGCTTTGGACACTTCAAATACCTCAGT 
               
               
                 GCCCACAACTACAAGATTGAGCACACGGAGACAGATACTGTGGACCCCAGAAGCAA 
               
               
                 TGGACGGCCCCCCACTGCTGCTGCTGTCCCCAAATCTGCGAAATACATCGCTCAGGT 
               
               
                 GCTGCAGGACTCAGAGGTGGACGGGGATGGGGATGGGGCTCCTGGGAGCTCAGGGG 
               
               
                 ATGAGCCCCCATCATCCTCATCCCAAGATGAGGAGTTGCTGATGCCACCCGACGCCC 
               
               
                 TCACGGACACAGACTTCCAGTCTTGCGAGGACAGCCTCATAGAGAATGAGATTCAC 
               
               
                 CAGTAAGGGGAGGGAGGGGCCCTGGAGGCCACATCCTGCCCCACCCCACCCCCACT 
               
               
                 CCCACGGACACTAAAACGCTAATAATTTATTAGATCTAAAGCCCCTTCCTCCCCAGC 
               
               
                 CCCTGCTTTCATTAAGGTATTTAAACTTGGGGGTTTCACTGCTCTCCCCCATGATGGA 
               
               
                 GGGAGGGAGCCCCCCAACCTCAGTGAGGAGAGCCCCGAGCCGGCCCCGGGGCAAA 
               
               
                 GAGGGGTGCAGAGGGAGTTCCCCCAGATCAGTACCCCCCACCCCTCCCCAGCTAGT 
               
               
                 AGCATGACCAGGAGAGGGTTAATGAGAGCCAAGAGGAGTACCTGGTGCACCTGGTG 
               
               
                 CCGGTGGCTGGAGACCTGGGGGGCAGGTGGATCTGGGGCTGTTCCCCCCCCTCCGTT 
               
               
                 TTTTCCACCCCACAGTTCCTCCTGGGATCTGGCCCTCCAGGGAAGTGGAGCCTCCAG 
               
               
                 CCCCTAGGGGATGCATGAGGGGGGAGGGGGTGCTGAGTGGGAGGAAGAGTCAGGC 
               
               
                 TCACAGCTGGGGTGGCCTGGGGGTGGGGGTGGGCAAGGCTGACACTGGAAAATGGG 
               
               
                 TTTTTGCACTGTTTTTTTTTTGGTTTTTTTGTTCTTTTTTGTTTTTTTCCTTTAAAATAA 
               
               
                 AAACAAAGAAAAGCTCTGAAAAAAAAAAAAAAAAA 
               
               
                   
               
               
                 ALOX5 (SEQ ID NO: 8; GenBank NM_000698.3). 
               
               
                 CCGGGGCCAGGGACCAGTGGTGGGAGGAGGCTGCGGCGCTAGATGCGGACACCTG 
               
               
                 GACCGCCGCGCCGAGGCTCCCGGCGCTCGCTGCTCCCGCGGCCCGCGCCATGCCCTC 
               
               
                 CTACACGGTCACCGTGGCCACTGGCAGCCAGTGGTTCGCCGGCACTGACGACTACAT 
               
               
                 CTACCTCAGCCTCGTGGGCTCGGCGGGCTGCAGCGAGAAGCACCTGCTGGACAAGC 
               
               
                 CCTTCTACAACGACTTCGAGCGTGGCGCGGTGGATTCATACGACGTGACTGTGGACG 
               
               
                 AGGAACTGGGCGAGATCCAGCTGGTCAGAATCGAGAAGCGCAAGTACTGGCTGAAT 
               
               
                 GACGACTGGTACCTGAAGTACATCACGCTGAAGACGCCCCACGGGGACTACATCGA 
               
               
                 GTTCCCCTGCTACCGCTGGATCACCGGCGATGTCGAGGTTGTCCTGAGGGATGGACG 
               
               
                 CGCAAAGTTGGCCCGAGATGACCAAATTCACATTCTCAAGCAACACCGACGTAAAG 
               
               
                 AACTGGAAACACGGCAAAAACAATATCGATGGATGGAGTGGAACCCTGGCTTCCCC 
               
               
                 TTGAGCATCGATGCCAAATGCCACAAGGATTTACCCCGTGATATCCAGTTTGATAGT 
               
               
                 GAAAAAGGAGTGGACTTTGTTCTGAATTACTCCAAAGCGATGGAGAACCTGTTCATC 
               
               
                 AACCGCTTCATGCACATGTTCCAGTCTTCTTGGAATGACTTCGCCGACTTTGAGAAA 
               
               
                 ATCTTTGTCAAGATCAGCAACACTATTTCTGAGCGGGTCATGAATCACTGGCAGGAA 
               
               
                 GACCTGATGTTTGGCTACCAGTTCCTGAATGGCTGCAACCCTGTGTTGATCCGGCGC 
               
               
                 TGCACAGAGCTGCCCGAGAAGCTCCCGGTGACCACGGAGATGGTAGAGTGCAGCCT 
               
               
                 GGAGCGGCAGCTCAGCTTGGAGCAGGAGGTCCAGCAAGGGAACATTTTCATCGTGG 
               
               
                 ACTTTGAGCTGCTGGATGGCATCGATGCCAACAAAACAGACCCCTGCACACTCCAGT 
               
               
                 TCCTGGCCGCTCCCATCTGCTTGCTGTATAAGAACCTGGCCAACAAGATTGTCCCCA 
               
               
                 TTGCCATCCAGCTCAACCAAATCCCGGGAGATGAGAACCCTATTTTCCTCCCTTCGG 
               
               
                 ATGCAAAATACGACTGGCTTTTGGCCAAAATCTGGGTGCGTTCCAGTGACTTCCACG 
               
               
                 TCCACCAGACCATCACCCACCTTCTGCGAACACATCTGGTGTCTGAGGTTTTTGGCA 
               
               
                 TTGCAATGTACCGCCAGCTGCCTGCTGTGCACCCCATTTTCAAGCTGCTGGTGGCAC 
               
               
                 ACGTGAGATTCACCATTGCAATCAACACCAAGGCCCGTGAGCAGCTCATCTGCGAG 
               
               
                 TGTGGCCTCTTTGACAAGGCCAACGCCACAGGGGGCGGTGGGCACGTGCAGATGGT 
               
               
                 GCAGAGGGCCATGAAGGACCTGACCTATGCCTCCCTGTGCTTTCCCGAGGCCATCAA 
               
               
                 GGCCCGGGGCATGGAGAGCAAAGAAGACATCCCCTACTACTTCTACCGGGACGACG 
               
               
                 GGCTCCTGGTGTGGGAAGCCATCAGGACGTTCACGGCCGAGGTGGTAGACATCTAC 
               
               
                 TACGAGGGCGACCAGGTGGTGGAGGAGGACCCGGAGCTGCAGGACTTCGTGAACGA 
               
               
                 TGTCTACGTGTACGGCATGCGGGGCCGCAAGTCCTCAGGCTTCCCCAAGTCGGTCAA 
               
               
                 GAGCCGGGAGCAGCTGTCGGAGTACCTGACCGTGGTGATCTTCACCGCCTCCGCCCA 
               
               
                 GCACGCCGCGGTCAACTTCGGCCAGTACGACTGGTGCTCCTGGATCCCCAATGCGCC 
               
               
                 CCCAACCATGCGAGCCCCGCCACCGACTGCCAAGGGCGTGGTGACCATTGAGCAGA 
               
               
                 TCGTGGACACGCTGCCCGACCGCGGCCGCTCCTGCTGGCATCTGGGTGCAGTGTGGG 
               
               
                 CGCTGAGCCAGTTCCAGGAAAACGAGCTGTTCCTGGGCATGTACCCAGAAGAGCAT 
               
               
                 TTTATCGAGAAGCCTGTGAAGGAAGCCATGGCCCGATTCCGCAAGAACCTCGAGGC 
               
               
                 CATTGTCAGCGTGATTGCTGAGCGCAACAAGAAGAAGCAGCTGCCATATTACTACTT 
               
               
                 GTCCCCAGACCGGATTCCGAACAGTGTGGCCATCTGAGCACACTGCCAGTCTCACTG 
               
               
                 TGGGAAGGCCAGCTGCCCCAGCCAGATGGACTCCAGCCTGCCTGGCAGGCTGTCTG 
               
               
                 GCCAGGCCTCTTGGCAGTCACATCTCTTCCTCCGAGGCCAGTACCTTTCCATTTATTC 
               
               
                 TTTGATCTTCAGGGAACTGCATAGATTGATCAAAGTGTAAACACCATAGGGACCCAT 
               
               
                 TCTACACAGAGCAGGACTGCACAGCGTCCTGTCCACACCCAGCTCAGCATTTCCACA 
               
               
                 CCAAGCAGCAACAGCAAATCACGACCACTGATAGATGTCTATTCTTGTTGGAGACAT 
               
               
                 GGGATGATTATTTTCTGTTCTATTTGTGCTTAGTCCAATTCCTTGCACATAGTAGGTA 
               
               
                 CCCAATTCAATTACTATTGAATGAATTAAGAATTGGTTGCCATAAAAATAAATCAGT 
               
               
                 TCATTTAAAATGAAAAAAAAAAAAAAAAAAAA 
               
               
                   
               
               
                 CAMK4 (SEQ ID NO: 9; GenBank NM_001744.4). 
               
               
                 AGTCTCCCTCCAGCGGGCGGCGACTCCGGGTTCCCCCTCGCGCCCTCTCGCAGAGGC 
               
               
                 TCGCCCCCTTCCCCGCCCACCGTCCCTGCGAGCGCGGGCGGCGGCGGTGGGCGTGTG 
               
               
                 CGCGCGTGAAGGACGCCGCCTCTCTCTCGCTCCTGCGTTCGCAGGCGGCGGCTGGCG 
               
               
                 GCCGGCTTCTCGCTCGGGCAGCGGCGGCGGCGGCGGCGGCGGCTTCCGGAGTCCCG 
               
               
                 CTGCGAAGATGCTCAAAGTCACGGTGCCCTCCTGCTCCGCCTCGTCCTGCTCTTCGG 
               
               
                 TCACCGCCAGTGCGGCCCCGGGGACCGCGAGCCTCGTCCCGGATTACTGGATCGAC 
               
               
                 GGCTCCAACAGGGATGCGCTGAGCGATTTCTTCGAGGTGGAGTCGGAGCTGGGACG 
               
               
                 GGGTGCTACATCCATTGTGTACAGATGCAAACAGAAGGGGACCCAGAAGCCTTATG 
               
               
                 CTCTCAAAGTGTTAAAGAAAACAGTGGACAAAAAAATCGTAAGAACTGAGATAGGA 
               
               
                 GTTCTTCTTCGCCTCTCACATCCAAACATTATAAAACTTAAAGAGATATTTGAAACC 
               
               
                 CCTACAGAAATCAGTCTGGTCCTAGAACTCGTCACAGGAGGAGAACTGTTTGATAG 
               
               
                 GATTGTGGAAAAGGGATATTACAGTGAGCGAGATGCTGCAGATGCCGTTAAACAAA 
               
               
                 TCCTGGAGGCAGTTGCTTATCTACATGAAAATGGGATTGTCCATCGTGATCTCAAAC 
               
               
                 CAGAGAATCTTCTTTATGCAACTCCAGCCCCAGATGCACCACTCAAAATCGCTGATT 
               
               
                 TTGGACTCTCTAAAATTGTGGAACATCAAGTGCTCATGAAGACAGTATGTGGAACCC 
               
               
                 CAGGGTACTGCGCACCTGAAATTCTTAGAGGTTGTGCCTATGGACCTGAGGTGGACA 
               
               
                 TGTGGTCTGTAGGAATAATCACCTACATCTTACTTTGTGGATTTGAACCATTCTATGA 
               
               
                 TGAAAGAGGCGATCAGTTCATGTTCAGGAGAATTCTGAATTGTGAATATTACTTTAT 
               
               
                 CTCCCCCTGGTGGGATGAAGTATCTCTAAATGCCAAGGACTTGGTCAGAAAATTAAT 
               
               
                 TGTTTTGGATCCAAAGAAACGGCTGACTACATTTCAAGCTCTCCAGCATCCGTGGGT 
               
               
                 CACAGGTAAAGCAGCCAATTTTGTACACATGGATACCGCTCAAAAGAAGCTCCAAG 
               
               
                 AATTCAATGCCCGGCGTAAGCTTAAGGCAGCGGTGAAGGCTGTGGTGGCCTCTTCCC 
               
               
                 GCCTGGGAAGTGCCAGCAGCAGCCATGGCAGCATCCAGGAGAGCCACAAGGCTAGC 
               
               
                 CGAGACCCTTCTCCAATCCAAGATGGCAACGAGGACATGAAAGCTATTCCAGAAGG 
               
               
                 AGAGAAAATTCAAGGCGATGGGGCCCAAGCCGCAGTTAAGGGGGCACAGGCTGAG 
               
               
                 CTGATGAAGGTGCAAGCCTTAGAGAAAGTTAAAGGTGCAGATATAAATGCTGAAGA 
               
               
                 GGCCCCCAAAATGGTGCCCAAGGCAGTGGAGGATGGGATAAAGGTGGCTGACCTGG 
               
               
                 AACTAGAGGAGGGCCTAGCAGAGGAGAAGCTGAAGACTGTGGAGGAGGCAGCAGC 
               
               
                 TCCCAGAGAAGGGCAAGGAAGCTCTGCTGTGGGTTTTGAAGTTCCACAGCAAGATG 
               
               
                 TGATCCTGCCAGAGTACTAAACAGCTTCCTTCAGATCTGGAAGCCAAACACCGGCAT 
               
               
                 TTTATGTACTTTGTCCTTCAGCAAGAAAGGTGTGGAAGCATGATATGTACTATAGTG 
               
               
                 ATTCTGTTTTTGAGGTGCAAAAAACATACATATATACCAGTTGGTAATTCTAACTTC 
               
               
                 AATGCATGTGACTGCTTTATGAAAATAATAGTGTCTTCTATGGCATGTAATGGATAC 
               
               
                 CTAATACCGATGAGTTAAATCTTGCAAGTTAACACAACGTAACACTTAAAAGCATAC 
               
               
                 ATTTTCAGCAACCAGTGGCACATATTTGAAGTGAATAGTAGCAAATTGTTTTTGCTTT 
               
               
                 GAAAATCTAGCCATCCTACATCCTTTGGATTTCTTCACAAGGCAGTAATTCCTTTGAA 
               
               
                 CTACTGCTTAGCTAATACTAGGTAGTGCTAAAAGACATGTTCCCATAACTTTTACAA 
               
               
                 CATTTTACTTTTTATCATTGATGTGTTCAAACTGTTTACAAGGAGATGCTTATAGATG 
               
               
                 ATAGTTGTACATATGTGCAAAAAAAAATCCACTTGCAATGGTAAGAAATTGAAGTA 
               
               
                 TCCTTAAAGGCCATGAAGCCATATGTCCCTAAAAAAAAAAAAAAAAAAAAAAAAA 
               
               
                 AAAAAAAA 
               
               
                   
               
               
                 CDKN1A (SEQ ID NO: 10; NM_000389.4). 
               
               
                 GTTGTATATCAGGGCCGCGCTGAGCTGCGCCAGCTGAGGTGTGAGCAGCTGCCGAA 
               
               
                 GTCAGTTCCTTGTGGAGCCGGAGCTGGGCGCGGATTCGCCGAGGCACCGAGGCACT 
               
               
                 CAGAGGAGGCGCCATGTCAGAACCGGCTGGGGATGTCCGTCAGAACCCATGCGGCA 
               
               
                 GCAAGGCCTGCCGCCGCCTCTTCGGCCCAGTGGACAGCGAGCAGCTGAGCCGCGAC 
               
               
                 TGTGATGCGCTAATGGCGGGCTGCATCCAGGAGGCCCGTGAGCGATGGAACTTCGA 
               
               
                 CTTTGTCACCGAGACACCACTGGAGGGTGACTTCGCCTGGGAGCGTGTGCGGGGCCT 
               
               
                 TGGCCTGCCCAAGCTCTACCTTCCCACGGGGCCCCGGCGAGGCCGGGATGAGTTGG 
               
               
                 GAGGAGGCAGGCGGCCTGGCACCTCACCTGCTCTGCTGCAGGGGACAGCAGAGGAA 
               
               
                 GACCATGTGGACCTGTCACTGTCTTGTACCCTTGTGCCTCGCTCAGGGGAGCAGGCT 
               
               
                 GAAGGGTCCCCAGGTGGACCTGGAGACTCTCAGGGTCGAAAACGGCGGCAGACCAG 
               
               
                 CATGACAGATTTCTACCACTCCAAACGCCGGCTGATCTTCTCCAAGAGGAAGCCCTA 
               
               
                 ATCCGCCCACAGGAAGCCTGCAGTCCTGGAAGCGCGAGGGCCTCAAAGGCCCGCTC 
               
               
                 TACATCTTCTGCCTTAGTCTCAGTTTGTGTGTCTTAATTATTATTTGTGTTTTAATTTA 
               
               
                 AACACCTCCTCATGTACATACCCTGGCCGCCCCCTGCCCCCCAGCCTCTGGCATTAG 
               
               
                 AATTATTTAAACAAAAACTAGGCGGTTGAATGAGAGGTTCCTAAGAGTGCTGGGCA 
               
               
                 TTTTTATTTTATGAAATACTATTTAAAGCCTCCTCATCCCGTGTTCTCCTTTTCCTCTC 
               
               
                 TCCCGGAGGTTGGGTGGGCCGGCTTCATGCCAGCTACTTCCTCCTCCCCACTTGTCC 
               
               
                 GCTGGGTGGTACCCTCTGGAGGGGTGTGGCTCCTTCCCATCGCTGTCACAGGCGGTT 
               
               
                 ATGAAATTCACCCCCTTTCCTGGACACTCAGACCTGAATTCTTTTTCATTTGAGAAGT 
               
               
                 AAACAGATGGCACTTTGAAGGGGCCTCACCGAGTGGGGGCATCATCAAAAACTTTG 
               
               
                 GAGTCCCCTCACCTCCTCTAAGGTTGGGCAGGGTGACCCTGAAGTGAGCACAGCCTA 
               
               
                 GGGCTGAGCTGGGGACCTGGTACCCTCCTGGCTCTTGATACCCCCCTCTGTCTTGTG 
               
               
                 AAGGCAGGGGGAAGGTGGGGTCCTGGAGCAGACCACCCCGCCTGCCCTCATGGCCC 
               
               
                 CTCTGACCTGCACTGGGGAGCCCGTCTCAGTGTTGAGCCTTTTCCCTCTTTGGCTCCC 
               
               
                 CTGTACCTTTTGAGGAGCCCCAGCTACCCTTCTTCTCCAGCTGGGCTCTGCAATTCCC 
               
               
                 CTCTGCTGCTGTCCCTCCCCCTTGTCCTTTCCCTTCAGTACCCTCTCAGCTCCAGGTG 
               
               
                 GCTCTGAGGTGCCTGTCCCACCCCCACCCCCAGCTCAATGGACTGGAAGGGGAAGG 
               
               
                 GACACACAAGAAGAAGGGCACCCTAGTTCTACCTCAGGCAGCTCAAGCAGCGACCG 
               
               
                 CCCCCTCCTCTAGCTGTGGGGGTGAGGGTCCCATGTGGTGGCACAGGCCCCCTTGAG 
               
               
                 TGGGGTTATCTCTGTGTTAGGGGTATATGATGGGGGAGTAGATCTTTCTAGGAGGGA 
               
               
                 GACACTGGCCCCTCAAATCGTCCAGCGACCTTCCTCATCCACCCCATCCCTCCCCAG 
               
               
                 TTCATTGCACTTTGATTAGCAGCGGAACAAGGAGTCAGACATTTTAAGATGGTGGCA 
               
               
                 GTAGAGGCTATGGACAGGGCATGCCACGTGGGCTCATATGGGGCTGGGAGTAGTTG 
               
               
                 TCTTTCCTGGCACTAACGTTGAGCCCCTGGAGGCACTGAAGTGCTTAGTGTACTTGG 
               
               
                 AGTATTGGGGTCTGACCCCAAACACCTTCCAGCTCCTGTAACATACTGGCCTGGACT 
               
               
                 GTTTTCTCTCGGCTCCCCATGTGTCCTGGTTCCCGTTTCTCCACCTAGACTGTAAACC 
               
               
                 TCTCGAGGGCAGGGACCACACCCTGTACTGTTCTGTGTCTTTCACAGCTCCTCCCAC 
               
               
                 AATGCTGAATATACAGCAGGTGCTCAATAAATGATTCTTAGTGACTTTACTTGTAAA 
               
               
                 AAAAAAAAAAAAAAA 
               
               
                   
               
               
                 COCH (SEQ ID NO: 11; AY358900.1). 
               
               
                 GGGGCCTTGCCTTCCGCACTCGGGCGCAGCCGGGTGGATCTCGAGCAGGTGCGGAG 
               
               
                 CCCCGGGCGGCGGGCGCGGGTGCGAGGGATCCCTGACGCCTCTGTCCCTGTTTCTTT 
               
               
                 GTCGCTCCCAGCCTGTCTGTCGTCGTTTTGGCGCCCCCGCCTCCCCGCGGTGCGGGG 
               
               
                 TTGCACACCGATCCTGGGCTTCGCTCGATTTGCCGCCGAGGCGCCTCCCAGACCTAG 
               
               
                 AGGGGCGCTGGCCTGGAGCAGCGGGTCGTCTGTGTCCTCTCTCCTCTGCGCCGCGCC 
               
               
                 CGGGGATCCGAAGGGTGCGGGGCTCTGAGGAGGTGACGCGCGGGGCCTCCCGCACC 
               
               
                 CTGGCCTTGCCCGCATTCTCCCTCTCTCCCAGGTGTGAGCAGCCTATCAGTCACCATG 
               
               
                 TCCGCAGCCTGGATCCCGGCTCTCGGCCTCGGTGTGTGTCTGCTGCTGCTGCCGGGG 
               
               
                 CCCGCGGGCAGCGAGGGAGCCGCTCCCATTGCTATCACATGTTTTACCAGAGGCTTG 
               
               
                 GACATCAGGAAAGAGAAAGCAGATGTCCTCTGCCCAGGGGGCTGCCCTCTTGAGGA 
               
               
                 ATTCTCTGTGTATGGGAACATAGTATATGCTTCTGTATCGAGCATATGTGGGGCTGC 
               
               
                 TGTCCACAGGGGAGTAATCAGCAACTCAGGGGGACCTGTACGAGTCTATAGCCTAC 
               
               
                 CTGGTCGAGAAAACTATTCCTCAGTAGATGCCAATGGCATCCAGTCTCAAATGCTTT 
               
               
                 CTAGATGGTCTGCTTCTTTCACAGTAACTAAAGGCAAAAGTAGTACACAGGAGGCC 
               
               
                 ACAGGACAAGCAGTGTCCACAGCACATCCACCAACAGGTAAACGACTAAAGAAAA 
               
               
                 CACCCGAGAAGAAAACTGGCAATAAAGATTGTAAAGCAGACATTGCATTTCTGATT 
               
               
                 GATGGAAGCTTTAATATTGGGCAGCGCCGATTTAATTTACAGAAGAATTTTGTTGGA 
               
               
                 AAAGTGGCTCTAATGTTGGGAATTGGAACAGAAGGACCACATGTGGGCCTTGTTCA 
               
               
                 AGCCAGTGAACATCCCAAAATAGAATTTTACTTGAAAAACTTTACATCAGCCAAAG 
               
               
                 ATGTTTTGTTTGCCATAAAGGAAGTAGGTTTCAGAGGGGGTAATTCCAATACAGGAA 
               
               
                 AAGCCTTGAAGCATACTGCTCAGAAATTCTTCACGGTAGATGCTGGAGTAAGAAAA 
               
               
                 GGGATCCCCAAAGTGGTGGTGGTATTTATTGATGGTTGGCCTTCTGATGACATCGAG 
               
               
                 GAAGCAGGCATTGTGGCCAGAGAGTTTGGTGTCAATGTATTTATAGTTTCTGTGGCC 
               
               
                 AAGCCTATCCCTGAAGAACTGGGGATGGTTCAGGATGTCACATTTGTTGACAAGGCT 
               
               
                 GTCTGTCGGAATAATGGCTTCTTCTCTTACCACATGCCCAACTGGTTTGGCACCACA 
               
               
                 AAATACGTAAAGCCTCTGGTACAGAAGCTGTGCACTCATGAACAAATGATGTGCAG 
               
               
                 CAAGACCTGTTATAACTCAGTGAACATTGCCTTTCTAATTGATGGCTCCAGCAGTGT 
               
               
                 TGGAGATAGCAATTTCCGCCTCATGCTTGAATTTGTTTCCAACATAGCCAAGACTTTT 
               
               
                 GAAATCTCGGACATTGGTGCCAAGATAGCTGCTGTACAGTTTACTTATGATCAGCGC 
               
               
                 ACGGAGTTCAGTTTCACTGACTATAGCACCAAAGAGAATGTCCTAGCTGTCATCAGA 
               
               
                 AACATCCGCTATATGAGTGGTGGAACAGCTACTGGTGATGCCATTTCCTTCACTGTT 
               
               
                 AGAAATGTGTTTGGCCCTATAAGGGAGAGCCCCAACAAGAACTTCCTAGTAATTGTC 
               
               
                 ACAGATGGGCAGTCCTATGATGATGTCCAAGGCCCTGCAGCTGCTGCACATGATGCA 
               
               
                 GGAATCACTATCTTCTCTGTTGGTGTGGCTTGGGCACCTCTGGATGACCTGAAAGAT 
               
               
                 ATGGCTTCTAAACCGAAGGAGTCTCACGCTTTCTTCACAAGAGAGTTCACAGGATTA 
               
               
                 GAACCAATTGTTTCTGATGTCATCAGAGGCATTTGTAGAGATTTCTTAGAATCCCAG 
               
               
                 CAATAATGGTAACATTTTGACAACTGAAAGAAAAAGTACAAGGGGATCCAGTGTGT 
               
               
                 AAATTGTATTCTCATAATACTGAAATGCTTTAGCATACTAGAATCAGATACAAAACT 
               
               
                 ATTAAGTATGTCAACAGCCATTTAGGCAAATAAGCACTCCTTTAAAGCCGCTGCCTT 
               
               
                 CTGGTTACAATTTACAGTGTACTTTGTTAAAAACACTGCTGAGGCTTCATAATCATG 
               
               
                 GCTCTTAGAAACTCAGGAAAGAGGAGATAATGTGGATTAAAACCTTAAGAGTTCTA 
               
               
                 ACCATGCCTACTAAATGTACAGATATGCAAATTCCATAGCTCAATAAAAGAATCTGA 
               
               
                 TACTTAGACCAAAAAAAAAAA 
               
               
                   
               
               
                 DHRS4 (SEQ ID NO: 12; NM_021004.3). 
               
               
                 CTACTCTGTCACCGCCCCTGGGAAGAGTGGAACCCATACTTGCTGGTCTGATCCATG 
               
               
                 CACAAGGCGGGGCTGCTAGGCCTCTGTGCCCGGGCTTGGAATTCGGTGCGGATGGC 
               
               
                 CAGCTCCGGGATGACCCGCCGGGACCCGCTCGCAAATAAGGTGGCCCTGGTAACGG 
               
               
                 CCTCCACCGACGGGATCGGCTTCGCCATCGCCCGGCGTTTGGCCCAGGACGGGGCCC 
               
               
                 ATGTGGTCGTCAGCAGCCGGAAGCAGCAGAATGTGGACCAGGCGGTGGCCACGCTG 
               
               
                 CAGGGGGAGGGGCTGAGCGTGACGGGCACCGTGTGCCATGTGGGGAAGGCGGAGG 
               
               
                 ACCGGGAGCGGCTGGTGGCCACGGCTGTGAAGCTTCATGGAGGTATCGATATCCTA 
               
               
                 GTCTCCAATGCTGCTGTCAACCCTTTCTTTGGAAGCATAATGGATGTCACTGAGGAG 
               
               
                 GTGTGGGACAAGACTCTGGACATTAATGTGAAGGCCCCAGCCCTGATGACAAAGGC 
               
               
                 AGTGGTGCCAGAAATGGAGAAACGAGGAGGCGGCTCAGTGGTGATCGTGTCTTCCA 
               
               
                 TAGCAGCCTTCAGTCCATCTCCTGGCTTCAGTCCTTACAATGTCAGTAAAACAGCCTT 
               
               
                 GCTGGGCCTGACCAAGACCCTGGCCATAGAGCTGGCCCCAAGGAACATTAGGGTGA 
               
               
                 ACTGCCTAGCACCTGGACTTATCAAGACTAGCTTCAGCAGGATGCTCTGGATGGACA 
               
               
                 AGGAAAAAGAGGAAAGCATGAAAGAAACCCTGCGGATAAGAAGGTTAGGCGAGCC 
               
               
                 AGAGGATTGTGCTGGCATCGTGTCTTTCCTGTGCTCTGAAGATGCCAGCTACATCAC 
               
               
                 TGGGGAAACAGTGGTGGTGGGTGGAGGAACCCCGTCCCGCCTCTGAGGACCGGGAG 
               
               
                 ACAGCCCACAGGCCAGAGTTGGGCTCTAGCTCCTGGTGCTGTTCCCGCATTCACCCA 
               
               
                 CTGGCCTTTCCCACCTCTGCTCACCTTACTGTTCACCTCATCAAATCAGTTCTGCCCT 
               
               
                 GTGAAAAGATCCAGCCTTCCCTGCCGTCAAGGTGGCGTCTTACTCGGGATTTCTGCT 
               
               
                 GTTGTTGTGGCCTTGGGTAAAGGCCTCCCCTGAGAACACAGGACAGGCCTGCTGACA 
               
               
                 AGGCTGAGTCTACCTTGGCAAAGACCAAGATATTTTTTCCCGGGCCACTGGGGAATC 
               
               
                 TGAGGGGTGATGGGAGAGAAGGAACCTGGAGTGGAAGGAGCAGAGTTGCAAATTA 
               
               
                 ACAACTTGCAAATGAGGTGCAAATAAAATGCAGATGATTGCGCGGCTTTGAATCCA 
               
               
                 AAAAAAAAAAAAAAAAA 
               
               
                   
               
               
                 MICAL1 (SEQ ID NO: 13; NM_022765.3). 
               
               
                 CCCAAGACTGTCCCCGCTGGAGGCGGTAGAGGGATCCAGAAGTAATGAGATGCTAA 
               
               
                 TGAGTCGCGAATAAAGCCCGGGCGGCGCCCCGCGCCCCTCGCGGAAGCCCACACTC 
               
               
                 CGCGCGACTCCAGGCGCACGCCCCGGGCCGCCCCGCATCCCAGCATCCCCGCCCGA 
               
               
                 TCTCGGCGTTTCCGCCCCCGCCCCCGCCCCCGCCCTCCCACCCGCTCAGACCTGGTTG 
               
               
                 CCAGCCCAACAGGAAGCGGCCCCTCCCGGCTTCGGAGCCGCCGCCACTCATCTCTGC 
               
               
                 CCAGCTGCTGCCCTCCCCAGGAGGCCTCCATGGCTTCACCTACCTCCACCAACCCAG 
               
               
                 CGCATGCCCACTTTGAGAGCTTCCTGCAGGCCCAGCTGTGCCAGGACGTGCTGAGCA 
               
               
                 GCTTCCAGGAGCTGTGTGGGGCCCTGGGGCTGGAACCCGGTGGGGGGCTGCCCCAG 
               
               
                 TACCACAAGATCAAGGACCAGCTCAACTACTGGAGCGCCAAGTCACTGTGGACCAA 
               
               
                 GCTGGACAAGCGAGCAGGCCAGCCTGTCTACCAGCAGGGCCGGGCCTGCACCAGCA 
               
               
                 CCAAGTGCCTGGTGGTGGGTGCTGGACCTTGCGGGCTGCGGGTCGCTGTGGAGCTGG 
               
               
                 CGCTGCTGGGGGCCCGAGTGGTGCTGGTGGAAAAGCGCACCAAGTTCTCTCGCCAC 
               
               
                 AACGTGCTCCACCTCTGGCCCTTCACCATCCACGACCTGCGGGCACTCGGTGCTAAG 
               
               
                 AAGTTCTACGGGCGCTTCTGCACCGGCACCCTGGACCACATCAGCATCAGGCAGCTC 
               
               
                 CAGCTGCTTCTGCTGAAGGTAGCATTGCTGCTGGGGGTGGAAATTCACTGGGGTGTC 
               
               
                 ACTTTCACTGGCCTCCAGCCCCCTCCTAGGAAGGGGAGTGGCTGGCGTGCCCAGCTC 
               
               
                 CAACCCAACCCCCCTGCCCAGCTGGCCAACTATGAATTTGACGTCCTTATCTCGGCT 
               
               
                 GCAGGAGGTAAATTCGTCCCTGAAGGCTTCAAAGTTCGAGAAATGCGAGGCAAACT 
               
               
                 GGCCATTGGCATCACAGCCAACTTTGTGAATGGACGCACCGTGGAGGAGACACAGG 
               
               
                 TGCCGGAGATCAGTGGTGTAGCCAGGATCTACAACCAGAGCTTCTTCCAGAGCCTTC 
               
               
                 TCAAAGCCACAGGCATTGATCTGGAGAACATTGTGTACTACAAGGACGACACCCAC 
               
               
                 TACTTTGTGATGACAGCCAAGAAGCAGTGCCTGCTGCGGCTGGGGGTGCTGCGCCA 
               
               
                 GGACTGGCCAGACACCAATCGGCTGCTGGGCAGTGCCAATGTGGTGCCCGAGGCTC 
               
               
                 TGCAGCGCTTTACCCGGGCAGCTGCTGACTTTGCCACCCATGGCAAGCTCGGGAAAC 
               
               
                 TAGAGTTTGCCCAGGATGCCCATGGGCAGCCTGATGTCTCTGCCTTTGACTTCACGA 
               
               
                 GCATGATGCGGGCAGAGAGTTCTGCTCGTGTGCAAGAGAAGCATGGCGCCCGCCTG 
               
               
                 CTGCTGGGACTGGTGGGGGACTGCCTGGTGGAGCCCTTCTGGCCCCTGGGCACTGGA 
               
               
                 GTGGCACGGGGCTTCCTGGCAGCCTTTGATGCAGCCTGGATGGTGAAGCGGTGGGC 
               
               
                 AGAGGGCGCTGAGTCCCTAGAGGTGTTGGCTGAGCGTGAGAGCCTGTACCAGCTTCT 
               
               
                 GTCACAGACATCCCCAGAAAACATGCATCGCAATGTGGCCCAGTATGGGCTGGACC 
               
               
                 CAGCCACCCGCTACCCCAACCTGAACCTCCGGGCAGTGACCCCCAATCAGGTACGA 
               
               
                 GACCTGTATGATGTGCTAGCCAAGGAGCCTGTGCAGAGGAACAACGACAAGACAGA 
               
               
                 TACAGGGATGCCAGCCACCGGGTCGGCAGGCACCCAGGAGGAGCTGCTACGCTGGT 
               
               
                 GCCAGGAGCAGACAGCTGGGTACCCGGGAGTCCACGTCTCCGATTTGTCTTCCTCCT 
               
               
                 GGGCTGATGGGCTAGCTCTGTGTGCCCTGGTGTACCGGCTGCAGCCTGGCCTGCTGG 
               
               
                 AACCCTCAGAGCTGCAGGGGCTGGGAGCTCTGGAAGCAACTGCTTGGGCACTAAAG 
               
               
                 GTGGCAGAGAATGAGCTGGGCATCACACCGGTGGTGTCTGCACAGGCCGTGGTAGC 
               
               
                 AGGGAGTGACCCACTGGGCCTCATTGCCTACCTCAGCCACTTCCACAGTGCCTTCAA 
               
               
                 GAGCATGGCCCACAGCCCAGGCCCTGTCAGCCAGGCCTCCCCAGGGACCTCCAGTG 
               
               
                 CTGTATTATTCCTTAGTAAACTTCAGAGGACCCTGCAGCGATCCCGGGCCAAGGAAA 
               
               
                 ATGCAGAGGATGCTGGTGGCAAGAAGCTGCGCTTGGAGATGGAGGCCGAGACCCCA 
               
               
                 AGTACTGAGGTGCCACCTGACCCAGAGCCTGGTGTACCCCTGACACCCCCATCCCAA 
               
               
                 CACCAGGAGGCCGGTGCTGGGGACCTGTGTGCACTTTGTGGGGAACACCTCTATGTC 
               
               
                 CTGGAACGCCTCTGTGTCAACGGCCATTTCTTCCACCGGAGCTGCTTCCGCTGCCAT 
               
               
                 ACCTGTGAGGCCACACTGTGGCCAGGTGGCTACGAGCAGCACCCAGGAGATGGACA 
               
               
                 TTTCTACTGCCTCCAGCACCTGCCCCAGACAGACCACAAAGCGGAAGGCAGCGATA 
               
               
                 GAGGCCCTGAGAGTCCGGAGCTCCCCACACCAAGTGAGAATAGCATGCCACCAGGC 
               
               
                 CTCTCAACTCCCACAGCCTCGCAGGAGGGGGCCGGTCCTGTTCCAGATCCCAGCCAG 
               
               
                 CCCACCCGTCGGCAGATCCGCCTCTCCAGCCCGGAGCGCCAGCGGTTGTCCTCCCTT 
               
               
                 AACCTTACCCCTGACCCGGAAATGGAGCCTCCACCCAAGCCTCCCCGCAGCTGCTCC 
               
               
                 GCCTTGGCCCGCCACGCCCTGGAGAGCAGCTTTGTGGGCTGGGGCCTGCCAGTCCAG 
               
               
                 AGCCCTCAAGCTCTTGTGGCCATGGAGAAGGAGGAAAAAGAGAGTCCCTTCTCCAG 
               
               
                 TGAAGAGGAAGAAGAAGATGTGCCTTTGGACTCAGATGTGGAACAGGCCCTGCAGA 
               
               
                 CCTTTGCCAAGACCTCAGGCACCATGAATAACTACCCAACATGGCGTCGGACTCTGC 
               
               
                 TGCGCCGTGCGAAGGAGGAGGAGATGAAGAGGTTCTGCAAGGCCCAGACCATCCAA 
               
               
                 CGGCGACTAAATGAGATTGAGGCTGCCTTGAGGGAGCTAGAGGCCGAGGGCGTGAA 
               
               
                 GCTGGAGCTGGCCTTGAGGCGCCAGAGCAGTTCCCCAGAACAGCAAAAGAAACTAT 
               
               
                 GGGTAGGACAGCTGCTACAGCTCGTTGACAAGAAAAACAGCCTGGTGGCTGAGGAG 
               
               
                 GCCGAGCTCATGATCACGGTGCAGGAATTGAATCTGGAGGAGAAACAGTGGCAGCT 
               
               
                 GGACCAGGAGCTACGAGGCTACATGAACCGGGAAGAAAACCTAAAGACAGCTGCT 
               
               
                 GATCGGCAGGCTGAGGACCAGGTCCTGAGGAAGCTGGTGGATTTGGTCAACCAGAG 
               
               
                 AGATGCCCTCATCCGCTTCCAGGAGGAGCGCAGGCTCAGCGAGCTGGCCTTGGGGA 
               
               
                 CAGGGGCCCAGGGCTAGACGAGGGTGGGCCGTCTGCTTTCGTTCCCACAAAGAAAG 
               
               
                 CACCTCACCCCAGCACAGTGCCACCCCTGTTCATCTGGGCTGCCTGGCAGAGAGCCT 
               
               
                 TGCTGTTTACAATTAAAATGTTTCTGCCACAAAAAAAAAAAAAAAAAAA 
               
               
                   
               
               
                 MOB3B (SEQ ID NO: 14; AJ580636.1). 
               
               
                 ATGTCCATAGCCCTGAAGCAGGTATTCAACAAGGACAAGACCTTCCGACCCAAGAG 
               
               
                 GAAATTTGAACCTGGCACACAGAGGTTTGAGCTGCACAAACGGGCTCAGGCATCCC 
               
               
                 TCAACTCGGGTGTGGACCTGAAGGCGGCTGTGCAGTTGCCCAGTGGGGAGGACCAG 
               
               
                 AATGACTGGGTGGCAGTACATGTGGTGGACTTCTTCAATCGGATCAACCTCATCTAT 
               
               
                 GGCACCATCTGTGAGTTCTGCACCGAGCGGACCTGTCCTGTGATGTCAGGGGGCCCC 
               
               
                 AAATATGAGTATCGGTGGCAGGATGATCTCAAGTATAAGAAGCCAACAGCGCTGCC 
               
               
                 AGCTCCCCAGTACATGAACCTTCTTATGGATTGGATTGAGGTTCAGATCAACAACGA 
               
               
                 GGAAATATTTCCAACATGCGTGGGTGTTCCCTTCCCAAAGAACTTCCTTCAGATCTG 
               
               
                 CAAGAAGATCCTGTGCCGCCTTTTCCGGGTCTTTGTCCACGTCTATATCCACCACTTC 
               
               
                 GACCGGGTCATTGTGATGGGTGCAGAGGCCCATGTCAACACCTGCTACAAACACTTC 
               
               
                 TATTACTTTGTCACAGAGATGAACCTCATAGACCGCAAGGAGCTAGAGCCTTTGAAA 
               
               
                 GAAATGACGAGCAGGATGTGTCACTAA 
               
               
                   
               
               
                 NUSAP1 (SEQ ID NO: 15; NM_016359.4). 
               
               
                 GCGTTACAGGCCCTTTGGCGCCTGCGTATTCGTGAAGTGTGAAAAAAGCGCGCCTCT 
               
               
                 GTTGGGACGGGAAATCAGCCTTTCTATTGGTCAGGGTTAGAAACCCCGCCTTTGAGG 
               
               
                 CATTTTCAACCAATGGAAGCGCGGCATTCTTCATTTAAACTGTCTATAAATTTCTGCC 
               
               
                 TAGTCAAAGTTAAGAGTGGCGCCAGGGATTTGAACCGCGCTGACGAAGTTTGGTGA 
               
               
                 TCCATCTTCCGAGTATCGCCGGGATTTCGAATCGCGATGATCATCCCCTCTCTAGAG 
               
               
                 GAGCTGGACTCCCTCAAGTACAGTGACCTGCAGAACTTAGCCAAGAGTCTGGGTCTC 
               
               
                 CGGGCCAACCTGAGGGCAACCAAGTTGTTAAAAGCCTTGAAAGGCTACATTAAACA 
               
               
                 TGAGGCAAGAAAAGGAAATGAGAATCAGGATGAAAGTCAAACTTCTGCATCCTCTT 
               
               
                 GTGATGAGACTGAGATACAGATCAGCAACCAGGAAGAAGCTGAGAGACAGCCACTT 
               
               
                 GGCCATGTCACCAAAACAAGGAGAAGGTGCAAGACTGTCCGTGTGGACCCTGACTC 
               
               
                 ACAGCAGAATCATTCAGAGATAAAAATAAGTAATCCCACTGAATTCCAGAATCATG 
               
               
                 AAAAGCAGGAAAGCCAGGATCTCAGAGCTACTGCAAAAGTTCCTTCTCCACCAGAC 
               
               
                 GAGCACCAAGAAGCTGAGAATGCTGTTTCCTCAGGTAACAGAGATTCAAAGGTACC 
               
               
                 TTCAGAAGGAAAGAAATCTCTCTACACAGATGAGTCATCCAAACCTGGAAAAAATA 
               
               
                 AAAGAACTGCAATCACTACTCCAAACTTTAAGAAGCTTCATGAAGCTCATTTTAAGG 
               
               
                 AAATGGAGTCCATTGATCAATATATTGAGAGAAAAAAGAAACATTTTGAAGAACAC 
               
               
                 AATTCCATGAATGAACTGAAGCAGCAGCCCATCAATAAGGGAGGGGTCAGGACTCC 
               
               
                 AGTACCTCCAAGAGGAAGACTCTCTGTGGCTTCTACTCCCATCAGCCAACGACGCTC 
               
               
                 GCAAGGCCGGTCTTGTGGCCCTGCAAGTCAGAGTACCTTGGGTCTGAAGGGGTCACT 
               
               
                 CAAGCGCTCTGCTATCTCTGCAGCTAAAACGGGTGTCAGGTTTTCAGCTGCTACTAA 
               
               
                 AGATAATGAGCATAAGCGTTCACTGACCAAGACTCCAGCCAGAAAGTCTGCACATG 
               
               
                 TGACCGTGTCTGGGGGCACCCCAAAAGGCGAGGCTGTGCTTGGGACACACAAATTA 
               
               
                 AAGACCATCACGGGGAATTCTGCTGCTGTTATTACCCCATTCAAGTTGACAACTGAG 
               
               
                 GCAACGCAGACTCCAGTCTCCAATAAGAAACCAGTGTTTGATCTTAAAGCAAGTTTG 
               
               
                 TCTCGTCCCCTCAACTATGAACCACACAAAGGAAAGCTAAAACCATGGGGGCAATC 
               
               
                 TAAAGAAAATAATTATCTAAATCAACATGTCAACAGAATTAACTTCTACAAGAAAA 
               
               
                 CTTACAAACAACCCCATCTCCAGACAAAGGAAGAGCAACGGAAGAAACGCGAGCA 
               
               
                 AGAACGAAAGGAGAAGAAAGCAAAGGTTTTGGGAATGCGAAGGGGCCTCATTTTGG 
               
               
                 CTGAAGATTAATAATTTTTTAACATCTTGTAAATATTCCTGTATTCTCAACTTTTTTCC 
               
               
                 TTTTGTAAATTTTTTTTTTTTGCTGTCATCCCCACTTTAGTCACGAGATCTTTTTCTGC 
               
               
                 TAACTGTTCATAGTCTGTGTAGTGTCCATGGGTTCTTCATGTGCTATGATCTCTGAAA 
               
               
                 AGACGTTATCACCTTAAAGCTCAAATTCTTTGGGATGGTTTTTACTTAAGTCCATTAA 
               
               
                 CAATTCAGGTTTCTAACGAGACCCATCCTAAAATTCTGTTTCTAGATTTTTAATGTCA 
               
               
                 AGTTCCCAAGTTCCCCCTGCTGGTTCTAATATTAACAGAACTGCAGTCTTCTGCTAGC 
               
               
                 CAATAGCATTTACCTGATGGCAGCTAGTTATGCAAGCTTCAGGAGAATTTGAACAAT 
               
               
                 AACAAGAATAGGGTAAGCTGGGATAGAAAGGCCACCTCTTCACTCTCTATAGAATA 
               
               
                 TAGTAACCTTTATGAAACGGGGCCATATAGTTTGGTTATGACATCAATATTTTACCT 
               
               
                 AGGTGAAATTGTTTAGGCTTATGTACCTTCGTTCAAATATCCTCATGTAATTGCCATC 
               
               
                 TGTCACTCACTATATTCACAAAAATAAAACTCTACAACTCATTCTAACATTGCTTACT 
               
               
                 TAAAAGCTACATAGCCCTATCGAAATGCGAGGATTAATGCTTTAATGCTTTTAGAGA 
               
               
                 CAGGGTCTCACTGTGTTGCCCAGGCTGGTCTCAAACTCCACCAAATGTACTTCTTATT 
               
               
                 CATTTTATGGAAAAGACTAGGCTTTGCTTAGTATCATGTCCATGTTTCCTTCACCTCA 
               
               
                 GTGGAGCTTCTGAGTTTTATACTGCTCAAGATCGTCATAAATAAAATTTTTTCTCATT 
               
               
                 GTCATAGAAAAAAAAAAAAAAAAAA 
               
               
                   
               
               
                 IL27RA (SEQ ID NO: 16; NM_004843.3). 
               
               
                 GCGGAGGCGGCCTGCCGGGGTGGTTCGGCTTCCCGTTGCCGCCTCGGGCGCTGTACC 
               
               
                 CAGAGCTCGAAGAGGAGCAGCGCGGCCGCGCGGACCCGGCAAGGCTGGGCCGGAC 
               
               
                 TCGGGGCTCCCGAGGGACGCCATGCGGGGAGGCAGGGGCGCCCCTTTCTGGCTGTG 
               
               
                 GCCGCTGCCCAAGCTGGCGCTGCTGCCTCTGTTGTGGGTGCTTTTCCAGCGGACGCG 
               
               
                 TCCCCAGGGCAGCGCCGGGCCACTGCAGTGCTACGGAGTTGGACCCTTGGGCGACT 
               
               
                 TGAACTGCTCGTGGGAGCCTCTTGGGGACCTGGGAGCCCCCTCCGAGTTACACCTCC 
               
               
                 AGAGCCAAAAGTACCGTTCCAACAAAACCCAGACTGTGGCAGTGGCAGCCGGACGG 
               
               
                 AGCTGGGTGGCCATTCCTCGGGAACAGCTCACCATGTCTGACAAACTCCTTGTCTGG 
               
               
                 GGCACTAAGGCAGGCCAGCCTCTCTGGCCCCCCGTCTTCGTGAACCTAGAAACCCAA 
               
               
                 ATGAAGCCAAACGCCCCCCGGCTGGGCCCTGACGTGGACTTTTCCGAGGATGACCC 
               
               
                 CCTGGAGGCCACTGTCCATTGGGCCCCACCTACATGGCCATCTCATAAAGTTCTGAT 
               
               
                 CTGCCAGTTCCACTACCGAAGATGTCAGGAGGCGGCCTGGACCCTGCTGGAACCGG 
               
               
                 AGCTGAAGACCATACCCCTGACCCCTGTTGAGATCCAAGATTTGGAGCTAGCCACTG 
               
               
                 GCTACAAAGTGTATGGCCGCTGCCGGATGGAGAAAGAAGAGGATTTGTGGGGCGAG 
               
               
                 TGGAGCCCCATTTTGTCCTTCCAGACACCGCCTTCTGCTCCAAAAGATGTGTGGGTA 
               
               
                 TCAGGGAACCTCTGTGGGACGCCTGGAGGAGAGGAACCTTTGCTTCTATGGAAGGC 
               
               
                 CCCAGGGCCCTGTGTGCAGGTGAGCTACAAAGTCTGGTTCTGGGTTGGAGGTCGTGA 
               
               
                 GCTGAGTCCAGAAGGAATTACCTGCTGCTGCTCCCTAATTCCCAGTGGGGCGGAGTG 
               
               
                 GGCCAGGGTGTCCGCTGTCAACGCCACAAGCTGGGAGCCTCTCACCAACCTCTCTTT 
               
               
                 GGTCTGCTTGGATTCAGCCTCTGCCCCCCGTAGCGTGGCAGTCAGCAGCATCGCTGG 
               
               
                 GAGCACGGAGCTACTGGTGACCTGGCAACCGGGGCCTGGGGAACCACTGGAGCATG 
               
               
                 TAGTGGACTGGGCTCGAGATGGGGACCCCCTGGAGAAACTCAACTGGGTCCGGCTT 
               
               
                 CCCCCTGGGAACCTCAGTGCTCTGTTACCAGGGAATTTCACTGTCGGGGTCCCCTAT 
               
               
                 CGAATCACTGTGACCGCAGTCTCTGCTTCAGGCTTGGCCTCTGCATCCTCCGTCTGG 
               
               
                 GGGTTCAGGGAGGAATTAGCACCCCTAGTGGGGCCAACGCTTTGGCGACTCCAAGA 
               
               
                 TGCCCCTCCAGGGACCCCCGCCATAGCGTGGGGAGAGGTCCCAAGGCACCAGCTTC 
               
               
                 GAGGCCACCTCACCCACTACACCTTGTGTGCACAGAGTGGAACCAGCCCCTCCGTCT 
               
               
                 GCATGAATGTGAGTGGCAACACACAGAGTGTCACCCTGCCTGACCTTCCTTGGGGTC 
               
               
                 CCTGTGAGCTGTGGGTGACAGCATCTACCATCGCTGGACAGGGCCCTCCTGGTCCCA 
               
               
                 TCCTCCGGCTTCATCTACCAGATAACACCCTGAGGTGGAAAGTTCTGCCGGGCATCC 
               
               
                 TATTCTTGTGGGGCTTGTTCCTGTTGGGGTGTGGCCTGAGCCTGGCCACCTCTGGAA 
               
               
                 GGTGCTACCACCTAAGGCACAAAGTGCTGCCCCGCTGGGTCTGGGAGAAAGTTCCT 
               
               
                 GATCCTGCCAACAGCAGTTCAGGCCAGCCCCACATGGAGCAAGTACCTGAGGCCCA 
               
               
                 GCCCCTTGGGGACTTGCCCATCCTGGAAGTGGAGGAGATGGAGCCCCCGCCGGTTA 
               
               
                 TGGAGTCCTCCCAGCCCGCCCAGGCCACCGCCCCGCTTGACTCTGGGTATGAGAAGC 
               
               
                 ACTTCCTGCCCACACCTGAGGAGCTGGGCCTTCTGGGGCCCCCCAGGCCACAGGTTC 
               
               
                 TGGCCTGAACCACACGTCTGGCTGGGGGCTGCCAGCCAGGCTAGAGGGATGCTCAT 
               
               
                 GCAGGTTGCACCCCAGTCCTGGATTAGCCCTCTTGATGGATGAAGACACTGAGGACT 
               
               
                 CAGAGAGGCTGAGTCACTTACCTGAGGACACCCAGCCAGGCAGAGCTGGGATTGAA 
               
               
                 GGACCCCTATAGAGAAGGGCTTGGCCCCCATGGGGAAGACACGGATGGAAGGTGGA 
               
               
                 GCAAAGGAAAATACATGAAATTGAGAGTGGCAGCTGCCTGCCAAAATCTGTTCCGC 
               
               
                 TGTAACAGAACTGAATTTGGACCCCAGCACAGTGGCTCACGCCTGTAATCCCAGCAC 
               
               
                 TTTGGCAGGCCAAGGTGGAAGGATCACTTAGAGCTAGGAGTTTGAGACCAGCCTGG 
               
               
                 GCAATATAGCAAGACCCCTCACTACAAAAATAAAACATCAAAAACAAAAACAATTA 
               
               
                 GCTGGGCATGATGGCACACACCTGTAGTCCGAGCCACTTGGGAGGCTGAGGTGGGA 
               
               
                 GGATCGGTTGAGCCCAGGAGTTCGAAGCTGCAGGGACCTCTGATTGCACCACTGCA 
               
               
                 CTCCAGGCTGGGTAACAGAATGAGACCTTATCTCAAAAATAAACAAACTAATAAAA 
               
               
                 AGCAAAAAAAAAAAAAAAAAAAAAAAAAAAA 
               
               
                   
               
               
                 HBA2 (SEQ ID NO: 17; NM_000517.4). 
               
               
                 CATAAACCCTGGCGCGCTCGCGGGCCGGCACTCTTCTGGTCCCCACAGACTCAGAGA 
               
               
                 GAACCCACCATGGTGCTGTCTCCTGCCGACAAGACCAACGTCAAGGCCGCCTGGGG 
               
               
                 TAAGGTCGGCGCGCACGCTGGCGAGTATGGTGCGGAGGCCCTGGAGAGGATGTTCC 
               
               
                 TGTCCTTCCCCACCACCAAGACCTACTTCCCGCACTTCGACCTGAGCCACGGCTCTG 
               
               
                 CCCAGGTTAAGGGCCACGGCAAGAAGGTGGCCGACGCGCTGACCAACGCCGTGGCG 
               
               
                 CACGTGGACGACATGCCCAACGCGCTGTCCGCCCTGAGCGACCTGCACGCGCACAA 
               
               
                 GCTTCGGGTGGACCCGGTCAACTTCAAGCTCCTAAGCCACTGCCTGCTGGTGACCCT 
               
               
                 GGCCGCCCACCTCCCCGCCGAGTTCACCCCTGCGGTGCACGCCTCCCTGGACAAGTT 
               
               
                 CCTGGCTTCTGTGAGCACCGTGCTGACCTCCAAATACCGTTAAGCTGGAGCCTCGGT 
               
               
                 AGCCGTTCCTCCTGCCCGCTGGGCCTCCCAACGGGCCCTCCTCCCCTCCTTGCACCG 
               
               
                 GCCCTTCCTGGTCTTTGAATAAAGTCTGAGTGGGCAGCAAAAAAAAAAAAAAAAAA 
               
               
                   
               
               
                 PPM1F (SEQ ID NO: 18; NM_014634). 
               
               
                 AGGGACGGGAAGTGGGCGGGGCCGGCCGGCAGCAGCTTGCGGGACACGGAGCCGC 
               
               
                 GAGGAGACAGCTGAGGCCCGCGGAGACCAGGGGGTGAAGCCTGGAGACCCTCTTGC 
               
               
                 CCTGGCCTAGCTGCAGGCCCCCGGGATGCTTTGGGCATGTCCTCTGGAGCCCCACAG 
               
               
                 AAGAGCAGCCCAATGGCCAGTGGAGCTGAGGAGACCCCAGGCTTCCTGGACACGCT 
               
               
                 CCTGCAAGACTTCCCAGCCCTGCTGAACCCAGAGGACCCTCTGCCATGGAAGGCCCC 
               
               
                 AGGGACGGTGCTCAGCCAGGAGGAGGTGGAGGGCGAGCTGGCTGAGCTGGCCATG 
               
               
                 GGCTTTCTGGGCAGCAGGAAGGCCCCGCCACCACTTGCTGCTGCTCTGGCCCACGAA 
               
               
                 GCAGTTTCACAGCTGCTACAGACAGACCTTTCCGAATTCAGGAAGTTGCCCAGGGAG 
               
               
                 GAAGAAGAAGAGGAGGAGGACGATGACGAGGAGGAAAAGGCCCCTGTGACCTTGC 
               
               
                 TGGATGCCCAAAGCCTGGCACAGAGTTTCTTTAACCGCCTTTGGGAAGTCGCCGGCC 
               
               
                 AGTGGCAGAAGCAGGTGCCATTGGCTGCCCGGGCCTCACAGCGGCAGTGGCTGGTC 
               
               
                 TCCATCCACGCCATCCGGAACACTCGCCGCAAGATGGAGGACCGGCACGTGTCCCT 
               
               
                 CCCTTCCTTCAACCAGCTCTTCGGCTTGTCTGACCCTGTGAACCGCGCCTACTTTGCT 
               
               
                 GTGTTTGATGGTCACGGAGGCGTGGATGCTGCGAGGTACGCCGCTGTCCACGTGCAC 
               
               
                 ACCAACGCTGCCCGCCAGCCAGAGCTGCCCACAGACCCTGAGGGAGCCCTCAGAGA 
               
               
                 AGCCTTCCGGCGCACCGACCAGATGTTTCTCAGGAAAGCCAAGCGAGAGCGGCTGC 
               
               
                 AGAGCGGCACCACAGGTGTGTGTGCGCTCATTGCAGGAGCGACCCTGCACGTCGCC 
               
               
                 TGGCTCGGGGATTCCCAGGTCATTTTGGTACAGCAGGGACAGGTGGTGAAGCTGAT 
               
               
                 GGAGCCACACAGACCAGAACGGCAGGATGAGAAGGCGCGCATTGAAGCATTGGGT 
               
               
                 GGCTTTGTGTCTCACATGGACTGCTGGAGAGTCAACGGGACCCTGGCCGTCTCCAGA 
               
               
                 GCCATCGGGGATGTCTTCCAGAAGCCCTACGTGTCTGGGGAGGCCGATGCAGCTTCC 
               
               
                 CGGGCGCTGACGGGCTCCGAGGACTACCTGCTGCTTGCCTGTGATGGCTTCTTTGAC 
               
               
                 GTCGTACCCCACCAGGAAGTTGTTGGCCTGGTCCAGAGCCACCTGACCAGGCAGCA 
               
               
                 GGGCAGCGGGCTCCGTGTCGCCGAGGAGCTGGTGGCTGCGGCCCGGGAGCGGGGCT 
               
               
                 CCCACGACAACATCACGGTCATGGTGGTCTTCCTCAGGGACCCCCAAGAGCTGCTGG 
               
               
                 AGGGCGGGAACCAGGGAGAAGGGGACCCCCAGGCAGAAGGGAGGAGGCAGGACTT 
               
               
                 GCCCTCCAGCCTTCCAGAACCTGAGACCCAGGCTCCACCAAGAAGCTAGGTGGTTTC 
               
               
                 CAGGCCCCTGCCCTCCCCTTCCTCCCATCCTTGTCCTTCTCTCCCTCAGAAGCCTCAG 
               
               
                 GACCCAACAGGTGGCAGGCAGTGGACAGGGTGCCCGCCCCACAGTGCTTTCCCCAG 
               
               
                 CACCCCAGAGCCAGTCGGGACACCCCCCGCAGCCCGTCCTGGTGGCTGTGGAACTG 
               
               
                 CACTGGGTGGCGGGCAGATGGTGGAAGGCAGCTTAGGAGACCTCACCAAAGAGAA 
               
               
                 GATGGACCGGCTCTTGCTCCCAGCTCCTATTAGGCCCGGGGTGGGACCAGAGGTCAT 
               
               
                 AGGTGCCCAACGGCAGCCAAACCAAAGACACTGGTGTGCATGGGGCAGCATGGTTG 
               
               
                 TGCACGTGGGACCCTGGGGCGGACCCAGGAGCCAAACTCTTGAAGCACCCCCTGGG 
               
               
                 TCAGGCCCAGCAGCGGAGTGGCCAGCCCCAGTTTCCCATTGCTCCTCTCTGCGGCCA 
               
               
                 GGGCCAGGTGGGTTCATATTTACAGATATGCCCAGCCAGTCCTGGTCGGCCACACCA 
               
               
                 GTGTCCCAAAGAGGAGAGCGCAGCAGAGCCAGGGGTCTGTTCTGTAGCAGCCACCC 
               
               
                 CCCTGCCCCCACTCCAGGGCAGCCATGATGTGCTTGGGCCCACCAGGGCCTTCCGGG 
               
               
                 CTGCTCTCTTCCCTGAGCCCGGAACCGGCGACGCACATGTGTCTTTTGTTGGTGTGTT 
               
               
                 TGTTTTTTTCCAGGGAGGTCTAATTCCGAAGCAGTATTCCAGGTTTTCTCTTTGTTTT 
               
               
                 ATCAGTGCCAAGATGACCTGTTGTGTCATATAATTTAAGCAGAGCTTAGCATTTATT 
               
               
                 TTATTCTTTAGAAAACTTAAGTATTTACTTTTTTAAAGCTATTTTTCAAGGAACCTTTT 
               
               
                 TTTGCAGTATTATTGAATTTATTTTCTAAATCAGGATTGAAACAGGAACTTTTCCAGG 
               
               
                 TGGTGTTAATAAGCCATTCAAGTGCCTTACACAGCTTTGAAGAAACTAGGACTGCAG 
               
               
                 TGGGCTCGGATAGGCCCATTGAGGTTTTTAGAAAAGCAGGATTTGTTTTGTTAGGGA 
               
               
                 GGCATGATTTTGGTGAGATCTTTCTGGAAGAGTTTTCCGCCTCTTTGTGATGCTGAAC 
               
               
                 ACCCCCAAGGTTCTCCCCTCCCCCCGCTGCCCAGGTGACTGGCAGGAGCTGCGACTG 
               
               
                 CCACGTAGTGGTGCCTGGGCCCGACAGCGGGGCTCTGGGCATCCCGGGTGACCTTG 
               
               
                 GCCCATCTGCCTGCATTCCCACCCCCTTGGGCCTGGCTGGATCCCAGGCAGAGGGAC 
               
               
                 CTTGCTGCTGTGTGATTGGAACATTCCCAAATATCTTGTGAATTTGTAATCAAATTGG 
               
               
                 TCTCATTGGGAAAGACTCTTAATTAAGAGGCTCAGGCAAGCACAGAGGCAGCCCGT 
               
               
                 GGGTCTCTGTCTCAGTCTGGAGGCAGCAGGGATGCTGCTGGGAGTCCATGGCACAG 
               
               
                 GCCACAGCCCCTCACCTTGCCGCGGTGGCTGGCAGCACGCCTGCCTTGCTCTGCCCC 
               
               
                 ATGCCCTGAACAGGCATGAGAGCTCCACGTCCCCTAGTGCACCCTGAGAGGGGGCT 
               
               
                 CACAAGTGACCGATCCTGGGTGCCTCAGGGAGCTCACTGAGGGCGTGCAAAGTTGA 
               
               
                 AAGTGGCAAGGCTGGGGGAGGGTGTCGGGTAGAGGGAAGAGGGCAGGGGGCTAGG 
               
               
                 GGAGGACTCAGAGGCCATCTGCAGGGCCAAGCCACAGGAAGGGCTGAGCTGGAGG 
               
               
                 TGGGCAGGGCTGCTCCAGGCAGGTCAGAGCAGTGCAGGGGGAGGAGAGGAGAAAG 
               
               
                 GGAGGAAGCTGGGCTGTGTGGTCCCCATGAAGGCATTCAGAGTCCACCTGCAGACA 
               
               
                 GCGAGAGCCCCAGGAAGGTTTGCACAGCTGTGCCCCAAGCACCTTGGCCTCCTCTCA 
               
               
                 GCTCGCCGAGGAGGCACGCTAGAGCCGCCTTCCCGGTGGGAGCCCTCTGTCCCACA 
               
               
                 GGGAGCGGGGAGCCAGCTTTGCTGGGGCCCTACCTGCATGCCCAGCCTTACCCCTCA 
               
               
                 TTCTCACAGCACAGATGAGGTTGAGACCATGCAGTCAATGCATTGCTTAAGGTCTCT 
               
               
                 TATTTACAAAAAAAAACCTTAAACATAGTCGCTGTCATTCAGACATTCAGAGAATGG 
               
               
                 TTGGCCACAAACAATGACCAAGTATTGCTTGGCTTAACTTGAAGGCCTGCTGTCTCC 
               
               
                 TTCTGGGGGTCAGGGACGCAGCTCCACCCTCACCACTAGCCCACCCTGCCCGTGGGC 
               
               
                 ATAACCTTGACGAAGAGAGAGAATGATTGGCATCTGCTTTTCTCTTTTCTTTGCTAAT 
               
               
                 AATTCTGTTCCTGGCTGCCGAGAGTGAAGTTTCACCATGTGGAGGTTTGGCTCCTAT 
               
               
                 CACCTGGTGGTCTGATTCATACCCTAGCCTGAGGCTCCACTGGAAGATCTCGCAGCC 
               
               
                 TCAGTGTATGGGAAACCCTTTCCCCAGGCTTGTCCCAGCACTGCCGCTCCCCACCCC 
               
               
                 TGAGCCAGGACCCCAGAGGATGGCCATGCCCCGTGCCTGGCAGAGGTCTGGTGCCA 
               
               
                 GCACTGGGAGCTGCTCCGCCCTTGCCTTGGGGCCGAGGGAGCCCTCGTCCACCCCTG 
               
               
                 CACAGCAGCTGGGCACAGAGGAGCGCTCTTCCATCTTGACCAGGACTGCACCAAGA 
               
               
                 AGCACCAGGTGTCTTCAGCCTCCAACCTCCGGGGCGACCTTCTCTTCCAGCCACAGT 
               
               
                 CCCATGAGGGCCCCTAGCCAGGGACACTGGTCTGTAAATTGTAATCCTTTCTCCAGC 
               
               
                 CCAGCTCTCCACTTGTTCCTTGTGTGAGCTGAGCAGGCAGTGCACCTCTGAGTGTCC 
               
               
                 CTTTTGTAAGGCCCAGGGGTTGCACTGAGTCTGCAGAGGCCGCGACCTCCTAGAACG 
               
               
                 CTGTGGGTGCAGGTGAGCCGGCGTGTCCTGGGGAGATGCTGCCAGCACACAGGGGC 
               
               
                 CCTCCTGCTGCCAGCAGGTTGGGGTGGTTAAGTCTTATTAGTGTCTATTCTTAAAATT 
               
               
                 AAGTGGGCTGGAGAAGAATGGAGCTCCACATGCCAGCACCGTATATGGAATACAAA 
               
               
                 AGCTGGGGAAGCAGGGCCTGCCTTACAGGTGTGGCTGACTCTGAGCCCAGGCCTGC 
               
               
                 AGGGGTGGAGGGCAGTCCCTCAGAATCCCAGAGGCAGTCCCAGCCTCAGAACCCAG 
               
               
                 GATAGGAAATGGGTGTGTTTAGTGGGGAAAGGGACGGGGTGCAGACGGCAGGGCC 
               
               
                 AGTATGGGGCCCCCTCCCTCTCCTCTCCTCTCCTATGGTGAGCCCAGCGTGGGCACC 
               
               
                 GGGCCGTCTCAGCCGTGTTCCCAGGGCTGGGAGGACAGCTCTGGCCCTTCTTAGGCC 
               
               
                 TAGCCTCGTCCCAAGCTAAATGTAAGCCAGTTGGGCTGTGTTAAAGGAAGCAGTGTT 
               
               
                 TTTGGTTCGATTCTGCCTCTGTAGCTCAAGGGGGGCAGCCCCCAGAGTCCTGTGCAT 
               
               
                 TCTGCCAAGGCTCCATAGCTTTGCCAAATGCACGGAGCTCTGCCATTCCGGTGCAGT 
               
               
                 GCAGGCCTTGCGAAGGGTTTATCTGCGTTCGTCTCGGTGGGCTTCTCCTGCATGGGA 
               
               
                 GTTGTGTTCCTGTGCAAGGGGGAGCTTTGCTCCAGGACAGGATGACTGTCTTCCCTA 
               
               
                 TTCTTAGGGACAAGTCCCAAGATGCCAGAAAGGCAGTCTCCCAAGGACCCACCATG 
               
               
                 CAGAAGTGTCAATAAACCACAAGTTCTGAACTCTGTAAAAAAAAAAAAAA 
               
               
                   
               
               
                 PPP2R1A (SEQ ID NO: 19; CR4503401). 
               
               
                 ATGGCGGCGGCCGACGGCGACGACTCGCTGTACCCCATCGCGGTGCTCATAGACGA 
               
               
                 ACTCCGCAATGAGGACGTTCAGCTTCGCCTCAACAGCATCAAGAAGCTGTCCACCAT 
               
               
                 CGCCTTGGCCCTTGGGGTTGAAAGGACCCGAAGTGAGCTTCTGCCTTTCCTTACAGA 
               
               
                 TACCATCTATGATGAAGATGAGGTCCTCCTGGCCCTGGCAGAACAGCTGGGAACCTT 
               
               
                 CACTACCCTGGTGGGAGGCCCAGAGTACGTGCACTGCCTGCTGCCACCGCTGGAGTC 
               
               
                 GCTGGCCACAGTGGAGGAGACAGTGGTGCGGGACAAGGCAGTGGAGTCCTTACGGG 
               
               
                 CCATCTCACACGAGCACTCGCCCTCTGACCTGGAGGCGCACTTTGTGCCGCTAGTGA 
               
               
                 AGCGGCTGGCGGGCGGCGACTGGTTCACCTCCCGCACCTCGGCCTGCGGCCTCTTCT 
               
               
                 CCGTCTGCTACCCCCGAGTGTCCAGTGCTGTGAAGGCGGAACTTCGACAGTACTTCC 
               
               
                 GGAACCTGTGCTCAGATGACACCCCCATGGTGCGGCGGGCCGCAGCCTCCAAGCTG 
               
               
                 GGGGAGTTTGCCAAGGTGCTGGAGCTGGACAACGTCAAGAGTGAGATCATCCCCAT 
               
               
                 GTTCTCCAACCTGGCCTCTGACGAGCAGGACTCGGTGCGGCTGCTGGCGGTGGAGG 
               
               
                 CGTGCGTGAACATCGCCCAGCTTCTGCCCCAGGAGGATCTGGAGGCCCTGGTGATGC 
               
               
                 CCACTCTGCGCCAGGCCGCTGAAGACAAGTCCTGGCGCGTCCGCTACATGGTGGCTG 
               
               
                 ACAAGTTCACAGAGCTCCAGAAAGCAGTGGGGCCTGAGATCACCAAGACAGACCTG 
               
               
                 GTCCCTGCCTTCCAGAACCTGATGAAAGACTGTGAGGCCGAGGTGAGGGCCGCAGC 
               
               
                 CTCCCACAAGGTCAAAGAGTTCTGTGAAAACCTCTCAGCTGACTGTCGGGAGAATGT 
               
               
                 GATCATGTCCCAGATCTTGCCCTGCATCAAGGAGCTGGTGTCCGATGCCAACCAACA 
               
               
                 TGTCAAGTCTGCCCTGGCCTCAGTCATCATGGGTCTCTCTCCCATCTTGGGCAAAGA 
               
               
                 CAACACCATCGAGCACCTCTTGCCCCTCTTCCTGGCTCAGCTGAAGGATGAGTGCCC 
               
               
                 TGAGGTACGGCTGAACATCATCTCTAACCTGGACTGTGTGAACGAGGTGATTGGCAT 
               
               
                 CCGGCAGCTGTCCCAGTCCCTGCTCCCTGCCATTGTGGAGCTGGCTGAGGACGCCAA 
               
               
                 GTGGCGGGTGCGGCTGGCCATCATTGAGTACATGCCCCTCCTGGCTGGACAGCTGGG 
               
               
                 AGTGGAGTTCTTTGATGAGAAACTTAACTCCTTGTGCATGGCCTGGCTTGTGGATCA 
               
               
                 TGTATATGCCATCCGCGAGGCAGCCACCAGCAACCTGAAGAAGCTAGTGGAAAAGT 
               
               
                 TTGGGAAGGAGTGGGCCCATGCCACAATCATCCCCAAGGTCTTGGCCATGTCCGGA 
               
               
                 GACCCCAACTACCTGCACCGCATGACTACGCTCTTCTGCATCAATGTGCTGTCTGAG 
               
               
                 GTCTGTGGGCAGGACATCACCACCAAGCACATGCTACCCACGGTTCTGCGCATGGCT 
               
               
                 GGGGACCCGGTTGCCAATGTCCGCTTCAATGTGGCCAAGTCTCTGCAGAAGATAGG 
               
               
                 GCCCATCCCGGACAACAGCACCTTGCAGAGTGAAGTCAAGCCCATCCTAGAGAAGC 
               
               
                 TGACCCAGGACCAGGATGTGGACGTCAAATACTTTGCCCAGGAGGCTCTGACTGTTC 
               
               
                 TGTCTCTCGCC 
               
               
                   
               
               
                 CFLAR (SEQ ID NO: 20; NM_003879.5). 
               
               
                 ATACTCAGTCACACAAGCCATAGCAGGAAACAGCGAGCTTGCAGCCTCACCGACGA 
               
               
                 GTCTCAACTAAAAGGGACTCCCGGAGCTAGGGGTGGGGACTCGGCCTCACACAGTG 
               
               
                 AGTGCCGGCTATTGGACTTTTGTCCAGTGACAGCTGAGACAACAAGGACCACGGGA 
               
               
                 GGAGGTGTAGGAGAGAAGCGCCGCGAACAGCGATCGCCCAGCACCAAGTCCGCTTC 
               
               
                 CAGGCTTTCGGTTTCTTTGCCTCCATCTTGGGTGCGCCTTCCCGGCGTCTAGGGGAGC 
               
               
                 GAAGGCTGAGGTGGCAGCGGCAGGAGAGTCCGGCCGCGACAGGACGAACTCCCCC 
               
               
                 ACTGGAAAGGATTCTGAAAGAAATGAAGTCAGCCCTCAGAAATGAAGTTGACTGCC 
               
               
                 TGCTGGCTTTCTGTTGACTGGCCCGGAGCTGTACTGCAAGACCCTTGTGAGCTTCCCT 
               
               
                 AGTCTAAGAGTAGGATGTCTGCTGAAGTCATCCATCAGGTTGAAGAAGCACTTGATA 
               
               
                 CAGATGAGAAGGAGATGCTGCTCTTTTTGTGCCGGGATGTTGCTATAGATGTGGTTC 
               
               
                 CACCTAATGTCAGGGACCTTCTGGATATTTTACGGGAAAGAGGTAAGCTGTCTGTCG 
               
               
                 GGGACTTGGCTGAACTGCTCTACAGAGTGAGGCGATTTGACCTGCTCAAACGTATCT 
               
               
                 TGAAGATGGACAGAAAAGCTGTGGAGACCCACCTGCTCAGGAACCCTCACCTTGTTT 
               
               
                 CGGACTATAGAGTGCTGATGGCAGAGATTGGTGAGGATTTGGATAAATCTGATGTGT 
               
               
                 CCTCATTAATTTTCCTCATGAAGGATTACATGGGCCGAGGCAAGATAAGCAAGGAG 
               
               
                 AAGAGTTTCTTGGACCTTGTGGTTGAGTTGGAGAAACTAAATCTGGTTGCCCCAGAT 
               
               
                 CAACTGGATTTATTAGAAAAATGCCTAAAGAACATCCACAGAATAGACCTGAAGAC 
               
               
                 AAAAATCCAGAAGTACAAGCAGTCTGTTCAAGGAGCAGGGACAAGTTACAGGAATG 
               
               
                 TTCTCCAAGCAGCAATCCAAAAGAGTCTCAAGGATCCTTCAAATAACTTCAGGCTCC 
               
               
                 ATAATGGGAGAAGTAAAGAACAAAGACTTAAGGAACAGCTTGGCGCTCAACAAGA 
               
               
                 ACCAGTGAAGAAATCCATTCAGGAATCAGAAGCTTTTTTGCCTCAGAGCATACCTGA 
               
               
                 AGAGAGATACAAGATGAAGAGCAAGCCCCTAGGAATCTGCCTGATAATCGATTGCA 
               
               
                 TTGGCAATGAGACAGAGCTTCTTCGAGACACCTTCACTTCCCTGGGCTATGAAGTCC 
               
               
                 AGAAATTCTTGCATCTCAGTATGCATGGTATATCCCAGATTCTTGGCCAATTTGCCTG 
               
               
                 TATGCCCGAGCACCGAGACTACGACAGCTTTGTGTGTGTCCTGGTGAGCCGAGGAG 
               
               
                 GCTCCCAGAGTGTGTATGGTGTGGATCAGACTCACTCAGGGCTCCCCCTGCATCACA 
               
               
                 TCAGGAGGATGTTCATGGGAGATTCATGCCCTTATCTAGCAGGGAAGCCAAAGATG 
               
               
                 TTTTTTATTCAGAACTATGTGGTGTCAGAGGGCCAGCTGGAGGACAGCAGCCTCTTG 
               
               
                 GAGGTGGATGGGCCAGCGATGAAGAATGTGGAATTCAAGGCTCAGAAGCGAGGGCT 
               
               
                 GTGCACAGTTCACCGAGAAGCTGACTTCTTCTGGAGCCTGTGTACTGCGGACATGTC 
               
               
                 CCTGCTGGAGCAGTCTCACAGCTCACCATCCCTGTACCTGCAGTGCCTCTCCCAGAA 
               
               
                 ACTGAGACAAGAAAGAAAACGCCCACTCCTGGATCTTCACATTGAACTCAATGGCT 
               
               
                 ACATGTATGATTGGAACAGCAGAGTTTCTGCCAAGGAGAAATATTATGTCTGGCTGC 
               
               
                 AGCACACTCTGAGAAAGAAACTTATCCTCTCCTACACATAAGAAACCAAAAGGCTG 
               
               
                 GGCGTAGTGGCTCACACCTGTAATCCCAGCACTTTGGGAGGCCAAGGAGGGCAGAT 
               
               
                 CACTTCAGGTCAGGAGTTCGAGACCAGCCTGGCCAACATGGTAAACGCTGTCCCTA 
               
               
                 GTAAAAATACAAAAATTAGCTGGGTGTGGGTGTGGGTACCTGTATTCCCAGTTACTT 
               
               
                 GGGAGGCTGAGGTGGGAGGATCTTTTGAACCCAGGAGTTCAGGGTCATAGCATGCT 
               
               
                 GTGATTGTGCCTACGAATAGCCACTGCATACCAACCTGGGCAATATAGCAAGATCCC 
               
               
                 ATCTCTTTAAAAAAAAAAAAAAAGGACAGGAACTATCTTACTCAATGTATTAGTCAT 
               
               
                 GTTTCTCTAGAGGGACAGAACTAATAGGATACATGTATATAAAAAGGGGAGTTTATT 
               
               
                 AAGGAGTATTGACTCACATGATCACAGGGTTAGGTCCCACAATAGGTCATCTGCAA 
               
               
                 GCAAGGAAGCCAATTCAAGTCCCAAAGCTGAAGAACTTGGAGTCCAATGTTTGAGG 
               
               
                 GCAGGAAGCATTCAGCATGAGAGAAAGATGGAGGCCAGAAGACTACACCAGTCTA 
               
               
                 GTCTTTCCATGTTTTGCCTGCTTTTATTCTGGCAGTGCTGGCAGCTGATTAGATGGTG 
               
               
                 CCCACCCAGATTGAGGATGGTCTGCCTTTCCCAGTCCACTGACTCAAATGTTAAATC 
               
               
                 TCCTTTGGCAGCACCCTCACAGATGTACCCGGGAACACTTTGCATCCTTCTATTCAAT 
               
               
                 CAAGTTGATACTCAGTATTAACCATCACAGTCCATTTGGGCAACTATACCAAATTAC 
               
               
                 CATAGACCAGGTGACTTAAACAGCAGTTATTTCTCACAGTTCCGGAGGCTGGGAAAT 
               
               
                 CCAACATCTAAGTGGTAGCATATCTGGTGTCTGGTAAGGCATGCTTCCAGATCTTAC 
               
               
                 CAGATGTCAGTCTTTTGATGTTCTCACATGGCAGAAAAAGAGGATGCAAACTCTCAA 
               
               
                 GTATATCTTTAAGGGCACAAATTCCATTCATGAGGGCTCTACCCTCATCACCTAATT 
               
               
                 ACCTCCCAAAGGCCCCACCTTCTGATACTGTCACTTTGGGGATACTGTCTCCCCTTTG 
               
               
                 AATTCTGGGGGGAATACAAACATTCAGTTTGTAACAATAGCCTTATGATTTAGAGGT 
               
               
                 TACTTGTTCATTCACCTAGACCTCAAATTGCATTTTACAGCTAGTCAAGTATATCTTT 
               
               
                 CTCTGATTTGATAGTGTGACCTAAAAGGGGACCATTGTTTGAAATATCATTAGAGTT 
               
               
                 GCTTATTATTATTATTATTATTATTATTATTATTATTATTATTATTATTGAGACAGAGT 
               
               
                 TTCATTCTGCTGCCCAGGCTGGAGTGCAGTGGCATCATCTTGGCTCATTGCAACCTCT 
               
               
                 GCCTTCTGGGTTCAAGCGATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGATTACAG 
               
               
                 GCTCCTGCCACCACACCCGGCTAATTTTTGTATTTTTAGTGGAGACAGGGTTTCCACC 
               
               
                 ATGTTGGCCAGCGTGGTCTTGAACTCCTGACCTCAGGTGATTCACCAGCCTCGGCCT 
               
               
                 CCCAAAGTGCTGGGATTACAGGTGTGAGCCACTGCACCTGGCCTATTATTATTTTTA 
               
               
                 AATTTTTTTTTTTTAATTGATCATTCTTGGGTGTTTCTCACAGAGGGTGATTTGGCAG 
               
               
                 GGTCACAGGACAATAGTGGAGGGAAGGTCAGCAGATAAACAAGTGAACAAAGGTC 
               
               
                 TCTGGTTTTCCTAGGCAGAGGACCCTGCGGCCTTCCGCAGTGTTTGTGTCCCTGGGTA 
               
               
                 CTTGAGATTAGGGAGTGGTGATGACTCTTAAGGAGCATGCTGCCTTCAAGCATCTGT 
               
               
                 TTAACAAAGCACATCTTGCACTGCCCTTAATCCATTTAACCCTGAGTGGACACAGCA 
               
               
                 CATGTTTCAGAGAGCACAGGGTTGGGGGTAAGGTCATAGATCAACAGCATCCTAAG 
               
               
                 GCAGAAGAATTTTTCTTAGTACAGAACAAAATGAAGTCTCCCATGTCTACTTCTTTCT 
               
               
                 ACACAGACACAGCAACAATCTGATTTCTCTATCTTTTCCCCACCTTTCCCCCTTTTCT 
               
               
                 ATTCCACAAAACCGCCATCGTCATCATGGCCTGTTCTCAATGAGCTGTTGGGTACAC 
               
               
                 CTCCCAGACGGGGTGGCGGCTGGGCAGAGGGGCTCCTCACTTCCCAGATGGGGCGG 
               
               
                 CCAGGCGGACGCGCCCCCCACCTCCCTCCCGGACGGGATAGCTGGCCGGGCGGGGG 
               
               
                 CTGACCCCCCACCTCCCTCCCCGACGGGGCGGCTGGCCGGGCGGGGGCTGACCCCC 
               
               
                 ACGCCTCCCTCCCGGACGGGGCGGCTGCCAGGCGGAGGGGCTCCTCACTTCTCAGA 
               
               
                 CGGGGTGGCTGCTGGGCGGAGACGCTCCTCACTTCCCAGACAGGGTGGCTGTCGGG 
               
               
                 CGGAGGGGCTCCTCACTTCTCAGACGGGGCAGCTGCGGGCGGAGGGGCTCCTCACT 
               
               
                 TCTCAGACGGGGTGGCCGGGCAGAGAAGCTCCTCACATCCCAGACGGGGGGGCGGG 
               
               
                 GCAGAGGCGCTCCCCACATCTCAGACGATGGGCGGCCGGGCAGAGACGCTCCTCAC 
               
               
                 TTCATCCCAGACGGGGTGGCGGCCGGGCAGAAGCTGTAATCTCGGCACCCTGGGGG 
               
               
                 GCCAAGGCAGGCGGCTGGGAGGCGGAGGCCGTAGCCAGCTGAGATCACACCACTGC 
               
               
                 ACTCCAGCCTGGGCAACATTGAGCACTGAGTGGACGAGACTCTGCCCGCAATCCCG 
               
               
                 GCACCTCGGGAGGCCGAGGCTGGCAGATCACTCGCAGTCAGGAGCTGGAGACCAGC 
               
               
                 CCGGCCAACACAGTGAAACCCTGTCTCCACCAAAAAAATACGAAAACCAGTCAGGC 
               
               
                 GTGGCGGCGCCCGCAATGGCAGGCACGCGGCAGGCCGAGGCGGGAGAATCAGGCA 
               
               
                 GGGAGGCTGCAGTGAGCCGAGATGGCAGCAGTACAGTCCAGCTTCGGCTCGGCATC 
               
               
                 AGAGGGAGACCGTGGGGAGAGGGAGAAGAGAGGGAGGGGGAGAGGGCTATTTTTA 
               
               
                 AAATTTTTTAAAATTGCTGAACAGGGGTACCTCTGGGCAGTGTGTCAGAATACCACT 
               
               
                 TTTTAAATATTTTATGATTTATTTATTTTTCTATTTCTTGAGGTTTTAACTGATGTGTA 
               
               
                 TCTGTATGTCTATTTGTGTATATTTTGTCATGATCATGTAACAGAGTCTGAAAAGTGT 
               
               
                 CGAAGAGACAGTTTTCAGGAACAACAAGCAATTATTCCTACTTTCCAAGTTATTTTG 
               
               
                 ATGCCATGGTGGCTCATACCTATAATCTGAGTACTTTGGGAGGCTGAGGTGGACTGA 
               
               
                 TCACTTGAGCCCAGGAGTTTGAGACCAGCCTGGGCAACATAGCAAGACTCCATCTCT 
               
               
                 ACAAAAAAAGACAAAATTTAGCTGAGCGTGGTGGCGTGTTCCTGTAGTCCCAGCTA 
               
               
                 CTTGGGAGGCTGAAGTGAGTGGATCCCCTGAGCCCAGAGAGGTCAAGGTTGTGATG 
               
               
                 AGCTGTGATCACACCACTGCACTTCAGCATGGGAGACAGAGTGAGACCCTGTTTCAG 
               
               
                 AAAAAATAAATAAATAAAACCACCAGCACCACAAACAACAACAAAAAGTTATTTTG 
               
               
                 TACTTGTTTTGAGCACAGGACTCCTGAGGGTATCTTTGCATTTAATATTACATAGGG 
               
               
                 GTGCCAGTGGGAAGTAATGTGTATGCTTGGCCTCATGAGCTAAAACCCTGTGTTAAT 
               
               
                 TATGACAGAAGGAAAGTGTGTGAGAGAGATCTTAACTACCTAGCAGCTCTAGCTGC 
               
               
                 CATCTTGAACCATGAAGATACGGGCCACACGTAGGGGTAGCTGGGTAGTGAGCAGC 
               
               
                 AAGAAGCCTTGTTGGATGAGGGCACGAAGGAGCAGAATCACTGGAATCACTGTGTC 
               
               
                 AGCCCTAATTACCTACCTCTGGACTTTTATGTGAGGGGAAAAAAAATTGACAGTTTA 
               
               
                 TATTTATCTCAACCTAGTTAACCCAAGTGATGCATTGTTATGAGATTAAAATGTTTGG 
               
               
                 AGGCCGGGTGCGGTGGCTCACGCCTATAATCCCAGCCCTTTGGGAGGCCAAGGCGG 
               
               
                 GCGGATCACGAGGTCAGGAGATCAAGACCATCCTGGCTAACATGTAAAACCCCGTC 
               
               
                 TCTACTAAAAATACAAAAAATTAGCCAGGCGTTGTGGCGGTCGCCTGTAGTCCCTGC 
               
               
                 TATTTGGGAGGCCGAGGCAAGAGAACGGCATGAACCTGGGAGGTGGAGCTTGCAGC 
               
               
                 GAGCTGAGATCTTGCCACTGCACTCCAGCCTGGGCGACAGTGCGAGACTCTGTCTCA 
               
               
                 AAAATAAATAAATAAATAAATAATAAATAAAATGTTTGGAATGTTGGCTTCATCCCT 
               
               
                 GGGATGCAAGGCTGGTTCAACATACGCAAATCAAGAAACATAATTCATCACATAAA 
               
               
                 CAGAACTAAAGACAAAAACCACATGATTATCTCAATAGATACAGAAAAGGCCTTCA 
               
               
                 ATAAAATTCAACGTTGCTTCATGTTAAAAACTCTCAATAAACTAGGTATTGATGGAA 
               
               
                 AATATCTCAAAATAATAACCATTTATGACAAACCCACAGCCATTATCATACTGAATG 
               
               
                 GGCAAAAGCTGGAAGCATTCCCCTTGAAAACTGGCACAAGACAGGGATGCCGTCTC 
               
               
                 ACCACTCCTATTTAACATAGTATTGGAAGTTCTGGCCAAGAAAATCAGGCAAGAGA 
               
               
                 AACAAATAAGGGGTATTCAAATAGGAAAAGAGGAAGTAAAACTGTGTTTGCAGATG 
               
               
                 ACATGATACTATATCTAGAAAACCCCATTATCTCCACCCAAAAGTTCCTTAAGCTGA 
               
               
                 TAAGCAACTTCAGCAAAGTCTCAGGATACAAAATCAATGTGCAGAAATCACAAGCA 
               
               
                 TTCTATACACCAACAATACACAAGCAGAGAGCCAAATCATGAATGAACTCCCATTC 
               
               
                 ACAGTTGCTAGAAAGAGAATAAAATACCTAGGAATACAGCTAATAAGATGTGAAGG 
               
               
                 ATCTCTTCAAGGAGAACTACAAACCACTGCTCAAGGAAATAAGAGAGGACACAAAT 
               
               
                 GAAAAAACATTCCATTCTCGTGGATAGGAAGAATCAATATCATGAAAATGGCCATA 
               
               
                 CTACCCAAAGTAATTTATAGGTTCATTGCTATTCCCATTAAACTACTATTGACATTCT 
               
               
                 TCACAGAATTAGAAAAAAACTACTTTAAAATTCAAATGGAACCAAAAAAGAGCCCG 
               
               
                 TATAACCAAGACAACAATAAGCAAAAAGAACAAAGCTGGAAGCATCACACTACCC 
               
               
                 AACTTCAAAGTATACTGCAAGGCTACAGTAGCCAAAATGGCATGGTACTGGTACAA 
               
               
                 AAACAGACACATAGACCAATGGAACAGAATAGAGACCAGAGAAAGAAGACCACAC 
               
               
                 ATCTACAGCCATCTGATCATCGACAAACCTGACAAAAACAAGCAATGGGGAAAAGA 
               
               
                 TTCCCTATTTAATAAATGGTGCTGGGAAAACTGGCTAGCCATATGCAGAAAATTGAA 
               
               
                 ACTGACCCCTTCCTTACACCTTATACAAAAATTAACTCAAGATTAAAGACTTAATGT 
               
               
                 AAAACCTAAAACTATAAAAACCCTAGAAGAAAATCTATTTAATACCATTCAAGACA 
               
               
                 TAGGCACAAGCAAAGGTTTCATGACAAAAACATCAAAAGCAATTGCAACAAAAGCA 
               
               
                 AAAATTACAAATGGGATCTAATTAAACTAAAGAGCTCCTGCACAGCAAAAGAAACT 
               
               
                 ATCATTAGAGTGAACAGGCAACCTACAGAATGGGAGAACATTTTTGCAATCTATCCA 
               
               
                 TCTGACAAAGGTCTAATATCCAGAACCTACAAGGAACTTAAAACAAATTTACAAGG 
               
               
                 AAAAAAACAACCCCATCAAAAAGTGGACAAAGGACATGAACAGACACTTCTCAAA 
               
               
                 AGAAGACATTTATGTGGCCAACAAACATATAAAAAAAAGCTCAACCTTACTGATCA 
               
               
                 TTAGAGAAATGCAAAGGAGAACCACAATGAGATACCATCTCATGCCGGTCAGAATG 
               
               
                 GTGATTATTAAAAAGTCAAAAAACAACAGATGCTGGCGAGGCTGTGGAGAAGTAGG 
               
               
                 AACACTTTTACATTGTTGGTGGGAATGTAAATTAGTTCAACCGTTGTGGAAGTGTGT 
               
               
                 GTGGCTATTCCTCAAAGATCTAGAACTAGAAATACTATTTGTCCCAGCAATCCCATT 
               
               
                 ACTGGGTATATACCCAAAGGAATATAAACCATTTTATTATAAAGATACATGCACATT 
               
               
                 TTTGTTCATTGCAGCACTCTTCACAATAGCAAAGACACAATAGCAAATGCCCATCAA 
               
               
                 AGATAGACTGGATAAAGAAAATGTGGTACATATACACCATGGAATACTGTGCAGTG 
               
               
                 CAGCCATTACAGCTTTTGGTGATACAGTGAATCAGATTTTTCATTAATTCTTTTAATT 
               
               
                 GGTTATTACTGAACGTGAAAAAGTAATGTTTGTATTGAAATCTTGAGTCTGGCCATG 
               
               
                 TTTCTATTTTAAATTCATAAAGAATTCTAACAAGAGGAATTCCAAGAATGTCATAAA 
               
               
                 TGGATGTTTCTCCATGGATGAAGGAACTGTTTTATTCACTTGCTGATAATTCAGCCTA 
               
               
                 ATCCAGTTTGACATCATATAGATAAGTAGTTGAATTATGGATTTAAAATACATATCA 
               
               
                 TTTTCTAACTCCAAAGGTAATACTTATTTAAATGGTTTTGAAAATATAGAAAGGCAC 
               
               
                 AATTTCTTTTTAAATCTGTTATTCTCCACCACCACTCAATCTGTCTATCATCTATCTCT 
               
               
                 CCATTCATTCTTCCATTTGTTTATATCTGTTAATCTTTGTATGTGTTCATGTATAGCTT 
               
               
                 TTACATGATTGGAATCATAATGCATATTCCATTTTGAAGTCTGCTTTTTTTTACACAA 
               
               
                 AAATATGTTGTGAATATTTTCCTATATTATGAAATATCATTAGCTGAGCTTTTAGAAT 
               
               
                 TGACTGCATGTTTTGGTACCATTTAGATATAGTTTAAGATACTTAGAAGTTATGTGGC 
               
               
                 TTTGCCACTATGGATGAATCTTATTTACTCAATATTAATTACTTACAAATAACCTCAC 
               
               
                 CTAAACACTACTCAGCCATAAAAAGGAATGAATTAATGACATTCACAGCAACCTGG 
               
               
                 AGACTATTACTCTAAAGGAAGTAACTGAGGAATGGAAAACCAAACATTGTATGTTC 
               
               
                 TCACTCATAAGTGGGAGATAAGCTATGAGGATGCAAAGGCATAAGAAGGATACAAT 
               
               
                 GGACTTTGGGGACTTAGGGGAAAGGGTGGGAGGGGGGTGAAGGATAAAAGAATAC 
               
               
                 AAATTGGGTTCAGTGTATACTGCTCAGGTGATGGGTGCACCAGAATCTCACAAGTAA 
               
               
                 CCACTTAATTACTTACGCATGTAACCAGATACCACCTGTTCCCCAAACACCTATGGA 
               
               
                 AATAATTTTGTTTTTTTTTTTAAAAAAGGAATGAGATCATGTCCTTTGCAGGGACATG 
               
               
                 GATGAAGCTGGAAGCCATTATCCTCAGCAAACTAACAGAGGAGCAGGAAACCAAAC 
               
               
                 ACCACATGTTCTCACTTGTAAGCGGAAGCTGAACAATGAGAACACACGGACACAGG 
               
               
                 GATGAGATCAACACACACTGGGGCCTGATGCAGGGGCCGTAGCGGGGAGAGCATCA 
               
               
                 GGATAACTAGCTAATGCATGTGGGGCTTAATACCTAGGTGATAGGTTGATAGGTGCA 
               
               
                 GCAAACCACCATGGGACACGTTTACCTATGTAACAAACCCGCACATCCTGCACTTGT 
               
               
                 ATCCAGAACTTAAAATATTTTAAAAATCTTTAGAGAATACAAAAAAAAAAAAAAAG 
               
               
                 ATTCTTCAATGCATACACAATAAAATTGCAGTTCAGTCAAACATTGGAAGTCTTTCT 
               
               
                 CTGACTGTCTAGTTGGTATCTTCATTTTCAGCTTCTTCAAGATCCCACTCCAAACACT 
               
               
                 GTTAGCTCAGCCAAATTGAACAGCTCATATCTCCTACCTCTGGATCTTTGGTTCTGGT 
               
               
                 GATTGTATATTTCTGGACCATCTGGAACCCCAGCATATCACCCTACCCCACATCTCC 
               
               
                 ACATCCCCAAAATATAACCATACTTCAAGGGCAGTTCAAATACCATCTCCTTCTATC 
               
               
                 CTCCATGAAGTCAGTTATCTCTTCCATTGGAATTATCGCCCCCTCTCCTGAACAGTAC 
               
               
                 TATTTCGTGTGAATCTCCTCCAAGCCTTCTTTTCATTTTATATCTCATGCTGTAATTCT 
               
               
                 TGGAAAGTATGCTGTAGCTCAAGTGCAGAATTCTCATCAGTTTTATCTTTATATCTCT 
               
               
                 CCTAAACACTTTACCTGATGAAGAGCCTGGCATACACATAAATATATATTGAATGAA 
               
               
                 TCAGTGATGGATTGAAAAGAGAAATGATGGATCTCCTAAATTTTAACTTTTATAAAA 
               
               
                 TATTTTGATACATTCATGACCTTACTTTAGCAAGCAATGAACGTGATGTAAACTATT 
               
               
                 GTTGATATAGTTTTTATATTGGAAGTGTAAGTAGTTTGTGGCATGGGATTGTGACAT 
               
               
                 ATCCTAGGTTTCCTCATCTTCTTTTTATTGAAATGTAATTCACAAGCCATAAAATTTG 
               
               
                 CCCCTTTAAAGTAAATGATGCAGTGGATTTTAGTATATTTACAGAGTTGTGCAATCA 
               
               
                 TCACCACTATCTAATTCCAGAACATTTCCATCTACCTAGAAACTCCATACCAGTGAG 
               
               
                 CTGCCACTCTAATCCTCCTCTTCCCCCAGCCTCTAGAAACAATAATCCATTTTCTGTC 
               
               
                 TCTATGATTTGCCTGTTCTAGATATTTTATAAAAATAAACATGTGGCCTTTCGTGTCT 
               
               
                 GACTTCCTTCACTTAAAAAAAAAAAAAAAAAA 
               
               
                   
               
               
                 DHRS13 (SEQ ID NO: 21; NM_144683.3). 
               
               
                 CGCCTCCGCCTTCGGAGGCTGACGCGCCCGGGCGCCGTTCCAGGCCTGTGCAGGGC 
               
               
                 GGATCGGCAGCCGCCTGGCGGCGATCCAGGGCGGTGCGGGGCCTGGGCGGGAGCCG 
               
               
                 GGAGGCGCGGCCGGCATGGAGGCGCTGCTGCTGGGCGCGGGGTTGCTGCTGGGCGC 
               
               
                 TTACGTGCTTGTCTACTACAACCTGGTGAAGGCCCCGCCGTGCGGCGGCATGGGCAA 
               
               
                 CCTGCGGGGCCGCACGGCCGTGGTCACGGGCGCCAACAGCGGCATCGGAAAGATGA 
               
               
                 CGGCGCTGGAGCTGGCGCGCCGGGGAGCGCGCGTGGTGCTGGCCTGCCGCAGCCAG 
               
               
                 GAGCGCGGGGAGGCGGCTGCCTTCGACCTCCGCCAGGAGAGTGGGAACAATGAGGT 
               
               
                 CATCTTCATGGCCTTGGACTTGGCCAGTCTGGCCTCGGTGCGGGCCTTTGCCACTGC 
               
               
                 CTTTCTGAGCTCTGAGCCACGGTTGGACATCCTCATCCACAATGCCGGTATCAGTTC 
               
               
                 CTGTGGCCGGACCCGTGAGGCGTTTAACCTGCTGCTTCGGGTGAACCATATCGGTCC 
               
               
                 CTTTCTGCTGACACATCTGCTGCTGCCTTGCCTGAAGGCATGTGCCCCTAGCCGCGT 
               
               
                 GGTGGTGGTAGCCTCAGCTGCCCACTGTCGGGGACGTCTTGACTTCAAACGCCTGGA 
               
               
                 CCGCCCAGTGGTGGGCTGGCGGCAGGAGCTGCGGGCATATGCTGACACTAAGCTGG 
               
               
                 CTAATGTACTGTTTGCCCGGGAGCTCGCCAACCAGCTTGAGGCCACTGGCGTCACCT 
               
               
                 GCTATGCAGCCCACCCAGGGCCTGTGAACTCGGAGCTGTTCCTGCGCCATGTTCCTG 
               
               
                 GATGGCTGCGCCCACTTTTGCGCCCATTGGCTTGGCTGGTGCTCCGGGCACCAAGAG 
               
               
                 GGGGTGCCCAGACACCCCTGTATTGTGCTCTACAAGAGGGCATCGAGCCCCTCAGTG 
               
               
                 GGAGATATTTTGCCAACTGCCATGTGGAAGAGGTGCCTCCAGCTGCCCGAGACGAC 
               
               
                 CGGGCAGCCCATCGGCTATGGGAGGCCAGCAAGAGGCTGGCAGGGCTTGGGCCTGG 
               
               
                 GGAGGATGCTGAACCCGATGAAGACCCCCAGTCTGAGGACTCAGAGGCCCCATCTT 
               
               
                 CTCTAAGCACCCCCCACCCTGAGGAGCCCACAGTTTCTCAACCTTACCCCAGCCCTC 
               
               
                 AGAGCTCACCAGATTTGTCTAAGATGACGCACCGAATTCAGGCTAAAGTTGAGCCTG 
               
               
                 AGATCCAGCTCTCCTAACCCTCAGGCCAGGATGCTTGCCATGGCACTTCATGGTCCT 
               
               
                 TGAAAACCTCGGATGTGTGCGAGGCCATGCCCTGGACACTGACGGGTTTGTGATCTT 
               
               
                 GACCTCCGTGGTTACTTTCTGGGGCCCCAAGCTGTGCCCTGGACATCTCTTTTCCTGG 
               
               
                 TTGAAGGAATAATGGGTGATTATTTCTTCCTGAGAGTGACAGTAACCCCAGATGGAG 
               
               
                 AGATAGGGGTATGCTAGACACTGTGCTTCTCGGAAATTTGGATGTAGTATTTTCAGG 
               
               
                 CCCCACCCTTATTGATTCTGATCAGCTCTGGAGCAGAGGCAGGGAGTTTGCAATGTG 
               
               
                 ATGCACTGCCAACATTGAGAATTAGTGAACTGATCCCTTTGCAACCGTCTAGCTAGG 
               
               
                 TAGTTAAATTACCCCCATGTTAATGAAGCGGAATTAGGCTCCCGAGCTAAGGGACTC 
               
               
                 GCCTAGGGTCTCACAGTGAGTAGGAGGAGGGCCTGGGATCTGAACCCAAGGGTCTG 
               
               
                 AGGCCAGGGCCGACTGCCGTAAGATGGGTGCTGAGAAGTGAGTCAGGGCAGGGCA 
               
               
                 GCTGGTATCGAGGTGCCCCATGGGAGTAAGGGGACGCCTTCCGGGCGGATGCAGGG 
               
               
                 CTGGGGTCATCTGTATCTGAAGCCCCTCGGAATAAAGCGCGTTGACCGCCGAAAAA 
               
               
                 AAAAAAAAAAAAAAA 
               
               
                   
               
               
                 ACAA1 (SEQ ID NO: 22; NM_001607.3). 
               
               
                 GGGTTCCCAGGCCGACTCTCCTTGTGGTTGGCTGAGGCTGGAGGTGGACGGGACTTT 
               
               
                 TGGAGGGTCGCTCGCGTCTGTTCGCAGAGCTGTGGGCGGAGTTGAGGCCTTGGAGG 
               
               
                 CTGAGATGTGGTTCTGCGCGTGTGCGGACGGCTGTCTGTTAACTCCGCGGTCAGTTC 
               
               
                 CCGGACTGGTGGCTGGTCTGCAGGGTTGACCTGCGCAATGCAGAGGCTGCAGGTAG 
               
               
                 TGCTGGGCCACCTGAGGGGTCCGGCCGATTCCGGCTGGATGCCGCAGGCCGCGCCTT 
               
               
                 GCCTGAGCGGTGCCCCGCAGGCCTCGGCCGCGGACGTGGTGGTGGTGCACGGGCGG 
               
               
                 CGCACGGCCATCTGCCGGGCGGGCCGCGGCGGCTTCAAGGACACCACCCCCGACGA 
               
               
                 GCTTCTCTCGGCAGTCATGACCGCGGTTCTCAAGGACGTGAATCTGAGGCCGGAACA 
               
               
                 GCTGGGGGACATCTGTGTCGGAAATGTGCTGCAGCCTGGGGCCGGGGCAATCATGG 
               
               
                 CCCGAATCGCCCAGTTTCTGAGTGACATCCCGGAGACTGTGCCTTTGTCCACTGTCA 
               
               
                 ATAGACAGTGTTCGTCGGGGCTACAGGCAGTGGCCAGCATAGCAGGTGGCATCAGA 
               
               
                 AATGGGTCTTATGACATTGGCATGGCCTGTGGGGTGGAGTCCATGTCCCTGGCTGAC 
               
               
                 AGAGGGAACCCTGGAAATATTACTTCGCGCTTGATGGAGAAGGAGAAGGCCAGAGA 
               
               
                 TTGCCTGATTCCTATGGGGATAACCTCTGAGAATGTGGCTGAGCGGTTTGGCATTTC 
               
               
                 ACGGGAGAAGCAGGATACCTTTGCCCTGGCTTCCCAGCAGAAGGCAGCAAGAGCCC 
               
               
                 AGAGCAAGGGCTGTTTCCAAGCTGAGATTGTGCCTGTGACCACCACGGTCCATGATG 
               
               
                 ACAAGGGCACCAAGAGGAGCATCACTGTGACCCAGGATGAGGGTATCCGCCCCAGC 
               
               
                 ACCACCATGGAGGGCCTGGCCAAACTGAAGCCTGCCTTCAAGAAAGATGGTTCTAC 
               
               
                 CACAGCTGGAAACTCTAGCCAGGTGAGTGATGGGGCAGCTGCCATCCTGCTGGCCC 
               
               
                 GGAGGTCCAAGGCAGAAGAGTTGGGCCTTCCCATCCTTGGGGTCCTGAGGTCTTATG 
               
               
                 CAGTGGTTGGGGTCCCACCTGACATCATGGGCATTGGACCTGCCTATGCCATCCCAG 
               
               
                 TAGCTTTGCAAAAAGCAGGGCTGACAGTGAGTGACGTGGACATCTTCGAGATCAAT 
               
               
                 GAGGCCTTTGCAAGCCAGGCTGCCTACTGTGTGGAGAAGCTACGACTCCCCCCTGAG 
               
               
                 AAGGTGAACCCCCTGGGGGGTGCAGTGGCCTTAGGGCACCCACTGGGCTGCACTGG 
               
               
                 GGCACGACAGGTCATCACGCTGCTCAATGAGCTGAAGCGCCGTGGGAAGAGGGCAT 
               
               
                 ACGGAGTGGTGTCCATGTGCATCGGGACTGGAATGGGAGCCGCTGCCGTCTTTGAAT 
               
               
                 ACCCTGGGAACTGAGTGAGGTCCCAGGCTGGAGGCGCTACGCAGACAGTCCTGCTG 
               
               
                 CTCTAGCAGCAAGGCAGTAACACCACAAAAGCAAAACCACATGGGAAAACTCAGC 
               
               
                 ACTGGTGGTGGTGGCAGTGGACAGATCAAGGCACTTCAACTCATTTGGAAAATGTG 
               
               
                 AACACTGATGACATGGTATAGGAGTGGGTGGGGTGTTGAGCCACCCATCAGACCCT 
               
               
                 CTTTAGCTGTGCAAGATAAAAGCAGCCTGGGTCACCCAGGCCACAAGGCCATGGTT 
               
               
                 AATTCTTAAGGCAAGGCAAATCCATGGATGAGAAGTGCAATGGGCATAGTAAAAGT 
               
               
                 GCATGAATTTATCTTAAAAAAAAAAAAAAAAAAAAAA 
               
               
                   
               
               
                 INPP5J (SEQ ID NO: 23; NM_001284285.1). 
               
               
                 CAGGTTGAAATGGCTGATGACATCACTGGTTCCCGGGAGCGGTAGAGCTGGAGCCG 
               
               
                 GAGCCAAGGGAGTCCAGGCTGCCGGGGGCTGCAGACATGGAGGGCCAGAGCAGCA 
               
               
                 GGGGCAGCAGGAGGCCAGGGACCCGGGCTGGCCTGGGTTCCCTGCCCATGCCCCAG 
               
               
                 GGTGTTGCCCAAACTGGGGCACCCTCCAAGGTGGACTCAAGTTTTCAGCTCCCAGCA 
               
               
                 AAGAAGAACGCAGCCCTAGGACCCTCGGAACCAAGGTTGGCTCTGGCACCTGTAGG 
               
               
                 GCCACGGGCAGCTATGTCAGCTTCCTCGGAAGGACCGAGGCTGGCTCTGGCATCTCC 
               
               
                 CCGACCAATCCTGGCTCCACTGTGTACCCCTGAAGGGCAGAAAACAGCTACTGCCC 
               
               
                 ACCGCAGCTCCAGCCTGGCCCCAACATCTGTGGGCCAGCTGGTGATGTCTGCCTCAG 
               
               
                 CTGGACCAAAGCCTCCCCCAGCGACCACAGGCTCAGTTCTGGCTCCGACGTCCCTGG 
               
               
                 GGCTGGTGATGCCTGCCTCAGCAGGGCCAAGATCTCCCCCAGTCACCCTGGGGCCCA 
               
               
                 ATCTGGCCCCAACCTCCAGAGACCAGAAGCAGGAGCCACCTGCCTCCGTGGGACCC 
               
               
                 AAGCCAACACTGGCAGCCTCTGGCCTGAGCCTGGCCCTGGCTTCTGAGGAGCAGCC 
               
               
                 CCCAGAACTCCCCTCCACCCCTTCCCCGGTGCCCAGTCCAGTTCTGTCTCCAACTCAG 
               
               
                 GAACAGGCCCTGGCTCCAGCATCCACGGCATCAGGCGCAGCCTCTGTGGGACAGAC 
               
               
                 ATCAGCTAGAAAGAGGGATGCCCCAGCCCCTAGACCTCTCCCTGCTTCTGAGGGGC 
               
               
                 ATCTCCAGCCTCCAGCTCAGACATCTGGTCCTACAGGCTCCCCACCCTGCATCCAAA 
               
               
                 CCTCCCCAGACCCTCGGCTCTCCCCCTCCTTCCGAGCCCGGCCTGAGGCCCTCCACA 
               
               
                 GCAGCCCTGAGGATCCTGTTTTGCCACGGCCACCCCAGACCTTGCCCTTGGATGTGG 
               
               
                 GCCAGGGTCCTTCAGAGCCTGGCACTCACTCCCCTGGACTTCTGTCCCCCACCTTCC 
               
               
                 GGCCTGGGGCCCCCTCAGGCCAGACTGTGCCCCCACCTCTGCCCAAGCCACCCCGAT 
               
               
                 CACCCAGCCGTTCCCCAAGCCACTCCCCGAATCGCTCTCCCTGTGTTCCCCCAGCCC 
               
               
                 CTGACATGGCCCTCCCAAGGCTTGGCACACAGAGTACAGGGCCTGGCAGGTGCCTG 
               
               
                 AGCCCCAACCTTCAGGCCCAAGAAGCCCCAGCCCCAGTCACCACCTCCTCTTCTACA 
               
               
                 TCCACCCTGTCATCCTCCCCTTGGTCAGCTCAGCCTACCTGGAAGAGCGACCCCGGC 
               
               
                 TTCCGGATCACTGTGGTCACATGGAACGTGGGCACTGCCATGCCCCCAGACGATGTC 
               
               
                 ACATCCCTCCTCCACCTGGGCGGTGGTGACGACAGCGACGGCGCAGACATGATCGC 
               
               
                 CATAGGGTTGCAGGAAGTGAACTCCATGCTCAACAAGCGACTCAAGGACGCCCTCT 
               
               
                 TCACGGACCAGTGGAGTGAGCTGTTCATGGATGCGCTAGGGCCCTTCAACTTCGTGC 
               
               
                 TGGTGAGTTCGGTGAGGATGCAGGGTGTCATCCTGCTGCTGTTCGCCAAGTACTACC 
               
               
                 ACCTGCCCTTCCTGCGAGACGTGCAGACCGACTGCACGCGCACTGGCCTGGGCGGCT 
               
               
                 ACTGGGGTAACAAGGGTGGCGTGAGCGTGCGCCTGGCGGCCTTCGGGCACATGCTC 
               
               
                 TGCTTCCTGAACTGCCACTTGCCTGCGCATATGGACAAGGCGGAGCAGCGCAAAGA 
               
               
                 CAACTTCCAGACCATCCTCAGCCTCCAGCAGTTCCAAGGGCCGGGCGCACAGGGCA 
               
               
                 TCCTGGATCATGACCTCGTGTTCTGGTTCGGGGACCTGAACTTCCGCATTGAGAGCT 
               
               
                 ATGACCTGCACTTTGTCAAGTTTGCCATCGACAGTGACCAGCTCCATCAGCTCTGGG 
               
               
                 AGAAGGACCAGCTCAACATGGCCAAGAACACCTGGCCCATTCTGAAGGGCTTTCAG 
               
               
                 GAGGGGCCCCTCAACTTCGCTCCCACCTTCAAGTTTGATGTGGGTACCAACAAATAC 
               
               
                 GATACCAGTGCCAAGAAACGGAAGCCAGCTTGGACAGACCGTATCCTATGGAAGGT 
               
               
                 CAAGGCTCCAGGTGGGGGTCCCAGCCCCTCAGGACGGAAGAGCCACCGACTCCAGG 
               
               
                 TGACGCAGCACAGCTACCGCAGCCACATGGAATACACAGTCAGCGACCACAAGCCT 
               
               
                 GTGGCTGCCCAGTTCCTCCTGCAGTTTGCCTTCAGGGACGACATGCCACTGGTGCGG 
               
               
                 CTGGAGGTGGCAGATGAGTGGGTGCGGCCCGAGCAGGCGGTGGTGAGGTACCGCAT 
               
               
                 GGAAACAGTGTTCGCCCGCAGCTCCTGGGACTGGATCGGCTTATACCGGGTGGGTTT 
               
               
                 CCGCCATTGCAAGGACTATGTGGCTTATGTCTGGGCCAAACATGAAGATGTGGATGG 
               
               
                 GAATACCTACCAGGTAACATTCAGTGAGGAATCACTGCCCAAGGGCCATGGAGACT 
               
               
                 TCATCCTGGGCTACTATAGTCACAACCACAGCATCCTCATCGGCATCACTGAACCCT 
               
               
                 TCCAGATCTCGCTGCCTTCCTCGGAGTTGGCCAGCAGCAGCACAGACAGCTCAGGCA 
               
               
                 CCAGCTCAGAGGGAGAGGATGACAGCACACTGGAGCTCCTTGCACCCAAGTCCCGC 
               
               
                 AGCCCCAGTCCTGGCAAGTCCAAGCGACACCGCAGCCGCAGCCCGGGACTGGCCAG 
               
               
                 GTTCCCTGGGCTTGCCCTACGGCCCTCATCCCGTGAACGCCGTGGTGCCAGCCGTAG 
               
               
                 CCCCTCACCCCAGAGCCGCCGCCTGTCCCGAGTGGCTCCTGACAGGAGCAGTAATG 
               
               
                 GCAGCAGCCGGGGCAGTAGTGAAGAGGGGCCCTCTGGGTTGCCTGGCCCCTGGGCC 
               
               
                 TTCCCACCAGCTGTGCCTCGAAGCCTGGGCCTGTTGCCCGCCTTGCGCCTAGAGACT 
               
               
                 GTAGACCCTGGTGGTGGTGGCTCCTGGGGACCTGATCGGGAGGCCCTGGCGCCCAA 
               
               
                 CAGCCTGTCTCCTAGTCCCCAGGGCCATCGGGGGCTGGAGGAAGGGGGCCTGGGGC 
               
               
                 CCTGAGGGTGGGGTAGGCAGATGGGCCAAGGTGACCACCATTCTGCCTCAATCTTTT 
               
               
                 GCAAGCCCACCTGCCTCTCTCCTGCTGCTCCTCCAGCTGTATCTGCACCTGCCTCTCT 
               
               
                 GTCCTGGCCAGGGGTGGACAACTGGGGTCCCCCAAAACTCAGTCCTGGCACCTCAA 
               
               
                 CTGTGACAATCAGCAAAGCCCCACCCAGGCCCCCATCTGGGATGATGGGAGAGCTC 
               
               
                 TGGCAGATGTCCCAATCCTGGAGGTCATCCATTAGGAATTAAATTCTCCAGCCTCAA 
               
               
                 AAAAAAAAAAAAAAA 
               
               
                   
               
               
                 OAZ1 (SEQ ID NO: 24; NM_004152.2). 
               
               
                 TTTTGCGAACGGCGAGCAGCGGCGGCGGCGCGGAGAGACGCAGCGGAGGTTTTCCT 
               
               
                 GGTTTCGGACCCCAGCGGCCGGATGGTGAAATCCTCCCTGCAGCGGATCCTCAATAG 
               
               
                 CCACTGCTTCGCCAGAGAGAAGGAAGGGGATAAACCCAGCGCCACCATCCACGCCA 
               
               
                 GCCGCACCATGCCGCTCCTAAGCCTGCACAGCCGCGGCGGCAGCAGCAGTGAGAGT 
               
               
                 TCCAGGGTCTCCCTCCACTGCTGTAGTAACCCGGGTCCGGGGCCTCGGTGGTGCTCC 
               
               
                 TGATGCCCCTCACCCACCCCTGAAGATCCCAGGTGGGCGAGGGAATAGTCAGAGGG 
               
               
                 ATCACAATCTTTCAGCTAACTTATTCTACTCCGATGATCGGCTGAATGTAACAGAGG 
               
               
                 AACTAACGTCCAACGACAAGACGAGGATTCTCAACGTCCAGTCCAGGCTCACAGAC 
               
               
                 GCCAAACGCATTAACTGGCGAACAGTGCTGAGTGGCGGCAGCCTCTACATCGAGAT 
               
               
                 CCCGGGCGGCGCGCTGCCCGAGGGGAGCAAGGACAGCTTTGCAGTTCTCCTGGAGT 
               
               
                 TCGCTGAGGAGCAGCTGCGAGCCGACCATGTCTTCATTTGCTTCCACAAGAACCGCG 
               
               
                 AGGACAGAGCCGCCTTGCTCCGAACCTTCAGCTTTTTGGGCTTTGAGATTGTGAGAC 
               
               
                 CGGGGCATCCCCTTGTCCCCAAGAGACCCGACGCTTGCTTCATGGCCTACACGTTCG 
               
               
                 AGAGAGAGTCTTCGGGAGAGGAGGAGGAGTAGGGCCGCCTCGGGGCTGGGCATCC 
               
               
                 GGCCCCTGGGGCCACCCCTTGTCAGCCGGGTGGGTAGGAACCGTAGACTCGCTCATC 
               
               
                 TCGCCTGGGTTTGTCCGCATGTTGTAATCGTGCAAATAAACGCTCACTCCGAATTAG 
               
               
                 CGGTGTATTTCTTGAAGTTTAATATTGTGTTTGTGATACTGAAGTATTTGCTTTAATT 
               
               
                 CTAAATAAAAATTTATATTTTACTTTTTTATTGCTGGTTTAAGATGATTCAGATTATC 
               
               
                 CTTGTACTTTGAGGAGAAGTTTCTTATTTGGAGTCTTTTGGAAACAGTCTTAGTCTTT 
               
               
                 TAACTTGGAAAGATGAGGTATTAATCCCCTCCATTGCTCTCCAAAAGCCAATAAAGT 
               
               
                 GATTACACCCGA 
               
               
                   
               
               
                 PNOC (SEQ ID NO: 25; NM_006228). 
               
               
                 GCCAGGAAGGCTTGCAGGTTCTGCTGTTTGGTTGCTGAAGGGGGTCAGTGTGTGTAT 
               
               
                 GTGTCATGGAGGTGGGCAGGGAAGGGGAGGGCTGTGCGTGGGGGAGAGGATATAT 
               
               
                 ATGCTGGTGTGGCTGAGAAAGCGGAACCGAGCCTCGCATCCATCGGAGGGAGCCGG 
               
               
                 GGACTGACAGCTCTCAGCACCTGCTTCCTGCTCCTGCACCATGAAAGTCCTGCTTTG 
               
               
                 TGACCTGCTGCTGCTCAGTCTCTTCTCCAGTGTGTTCAGCAGTTGTCAGAGGGACTGT 
               
               
                 CTCACATGCCAGGAGAAGCTCCACCCAGCCCTGGACAGCTTCGACCTGGAGGTGTG 
               
               
                 CATCCTCGAGTGTGAAGAGAAGGTCTTCCCCAGCCCCCTCTGGACTCCATGCACCAA 
               
               
                 GGTCATGGCCAGGAGCTCTTGGCAGCTCAGCCCTGCCGCCCCAGAGCATGTGGCGG 
               
               
                 CTGCTCTCTACCAGCCGAGAGCTTCGGAGATGCAGCATCTGCGGCGAATGCCCCGA 
               
               
                 GTCCGGAGCTTGTTCCAGGAGCAGGAAGAGCCCGAGCCTGGCATGGAGGAGGCTGG 
               
               
                 TGAGATGGAGCAGAAGCAGCTGCAGAAGAGATTTGGGGGCTTCACCGGGGCCCGGA 
               
               
                 AGTCGGCCAGGAAGTTGGCCAATCAGAAGCGGTTCAGTGAGTTTATGAGGCAATAC 
               
               
                 TTGGTCCTGAGCATGCAGTCCAGCCAGCGCCGGCGCACCCTGCACCAGAATGGTAA 
               
               
                 TGTGTAGCCGGAAGGGGCGCTCCTCCCAGCTGTACCGGCCACTGCAACCCATGAGC 
               
               
                 GTCCAGGTGATCCCCCAAACAGCATGTGCTCAGCCCCAGACCTGCCGCCTGGGAATC 
               
               
                 AGGATTCCTTCTTCCCCAAGGCACTGAGCGCCTGCAGATCCCGCAGGCTTCGTTTGC 
               
               
                 CTCCAGAACCTTCCCGTCTGATTGTTCCTCCCCAGCCCCCTGGCATGTTTCACCACAA 
               
               
                 CCCTGTTGCTACATCAGAGTGTATTTTTGTAATTCCTCTAGCTACCATTTCAATAGCC 
               
               
                 CCATCTCTCCTGCTCACCCGCCTCTTGCCCCTTCTAGGGGCAGGTGAAAGGAATAGG 
               
               
                 AAATTGAACCTGGGGTTTTGACTTGCCACTGCCATAACTTGTTTGTAAAAGAGCTGT 
               
               
                 TCTTTTTGACTGATTGTTTTAAACAACGATTTCTCCATTAAACTTCTACTGAGCAAAT 
               
               
                 GGTTAATAAAAAAAAAAAAAAAAAA 
               
               
                   
               
               
                 PDE4B (SEQ ID NO: 26; NM_002600). 
               
               
                 AGAGCGCTGCGGCCGCGGCGGTGCAGCAGAGGCGCCTCGGGCAGGAGGAGGGCGG 
               
               
                 CTTCTGCGAGGGCAGCCTGAGGTATTAAAAAGTGTCAGCAAACTGCATTGAATAAC 
               
               
                 AGACATCCTAAGAGGGGATATTTTCCACCTCTATAATGAAGAAAAGCAGGAGTGTG 
               
               
                 ATGACGGTGATGGCTGATGATAATGTTAAAGATTATTTTGAATGTAGCTTGAGTAAA 
               
               
                 TCCTACAGTTCTTCCAGTAACACACTTGGGATCGACCTCTGGAGAGGGAGAAGGTGT 
               
               
                 TGCTCAGGAAACTTACAGTTACCACCACTGTCTCAAAGACAGAGTGAAAGGGCAAG 
               
               
                 GACTCCTGAGGGAGATGGTATTTCCAGGCCGACCACACTGCCTTTGACAACGCTTCC 
               
               
                 AAGCATTGCTATTACAACTGTAAGCCAGGAGTGCTTTGATGTGGAAAATGGCCCTTC 
               
               
                 CCCAGGTCGGAGTCCACTGGATCCCCAGGCCAGCTCTTCCGCTGGGCTGGTACTTCA 
               
               
                 CGCCACCTTTCCTGGGCACAGCCAGCGCAGAGAGTCATTTCTCTACAGATCAGACAG 
               
               
                 CGACTATGACTTGTCACCAAAGGCGATGTCGAGAAACTCTTCTCTTCCAAGCGAGCA 
               
               
                 ACACGGCGATGACTTGATTGTAACTCCTTTTGCCCAGGTCCTTGCCAGCTTGCGAAG 
               
               
                 TGTGAGAAACAACTTCACTATACTGACAAACCTTCATGGTACATCTAACAAGAGGTC 
               
               
                 CCCAGCTGCTAGTCAGCCTCCTGTCTCCAGAGTCAACCCACAAGAAGAATCTTATCA 
               
               
                 AAAATTAGCAATGGAAACGCTGGAGGAATTAGACTGGTGTTTAGACCAGCTAGAGA 
               
               
                 CCATACAGACCTACCGGTCTGTCAGTGAGATGGCTTCTAACAAGTTCAAAAGAATGC 
               
               
                 TGAACCGGGAGCTGACACACCTCTCAGAGATGAGCCGATCAGGGAACCAGGTGTCT 
               
               
                 GAATACATTTCAAATACTTTCTTAGACAAGCAGAATGATGTGGAGATCCCATCTCCT 
               
               
                 ACCCAGAAAGACAGGGAGAAAAAGAAAAAGCAGCAGCTCATGACCCAGATAAGTG 
               
               
                 GAGTGAAGAAATTAATGCATAGTTCAAGCCTAAACAATACAAGCATCTCACGCTTTG 
               
               
                 GAGTCAACACTGAAAATGAAGATCACCTGGCCAAGGAGCTGGAAGACCTGAACAAA 
               
               
                 TGGGGTCTTAACATCTTTAATGTGGCTGGATATTCTCACAATAGACCCCTAACATGC 
               
               
                 ATCATGTATGCTATATTCCAGGAAAGAGACCTCCTAAAGACATTCAGAATCTCATCT 
               
               
                 GACACATTTATAACCTACATGATGACTTTAGAAGACCATTACCATTCTGACGTGGCA 
               
               
                 TATCACAACAGCCTGCACGCTGCTGATGTAGCCCAGTCGACCCATGTTCTCCTTTCT 
               
               
                 ACACCAGCATTAGACGCTGTCTTCACAGATTTGGAGATCCTGGCTGCCATTTTTGCA 
               
               
                 GCTGCCATCCATGACGTTGATCATCCTGGAGTCTCCAATCAGTTTCTCATCAACACA 
               
               
                 AATTCAGAACTTGCTTTGATGTATAATGATGAATCTGTGTTGGAAAATCATCACCTT 
               
               
                 GCTGTGGGTTTCAAACTGCTGCAAGAAGAACACTGTGACATCTTCATGAATCTCACC 
               
               
                 AAGAAGCAGCGTCAGACACTCAGGAAGATGGTTATTGACATGGTGTTAGCAACTGA 
               
               
                 TATGTCTAAACATATGAGCCTGCTGGCAGACCTGAAGACAATGGTAGAAACGAAGA 
               
               
                 AAGTTACAAGTTCAGGCGTTCTTCTCCTAGACAACTATACCGATCGCATTCAGGTCC 
               
               
                 TTCGCAACATGGTACACTGTGCAGACCTGAGCAACCCCACCAAGTCCTTGGAATTGT 
               
               
                 ATCGGCAATGGACAGACCGCATCATGGAGGAATTTTTCCAGCAGGGAGACAAAGAG 
               
               
                 CGGGAGAGGGGAATGGAAATTAGCCCAATGTGTGATAAACACACAGCTTCTGTGGA 
               
               
                 AAAATCCCAGGTTGGTTTCATCGACTACATTGTCCATCCATTGTGGGAGACATGGGC 
               
               
                 AGATTTGGTACAGCCTGATGCTCAGGACATTCTCGATACCTTAGAAGATAACAGGAA 
               
               
                 CTGGTATCAGAGCATGATACCTCAAAGTCCCTCACCACCACTGGACGAGCAGAACA 
               
               
                 GGGACTGCCAGGGTCTGATGGAGAAGTTTCAGTTTGAACTGACTCTCGATGAGGAA 
               
               
                 GATTCTGAAGGACCTGAGAAGGAGGGAGAGGGACACAGCTATTTCAGCAGCACAAA 
               
               
                 GACGCTTTGTGTGATTGATCCAGAAAACAGAGATTCCCTGGGAGAGACTGACATAG 
               
               
                 ACATTGCAACAGAAGACAAGTCCCCCGTGGATACATAATCCCCCTCTCCCTGTGGAG 
               
               
                 ATGAACATTCTATCCTTGATGAGCATGCCAGCTATGTGGTAGGGCCAGCCCACCATG 
               
               
                 GGGGCCAAGACCTGCACAGGACAAGGGCCACCTGGCCTTTCAGTTACTTGAGTTTGG 
               
               
                 AGTCAGAAAGCAAGACCAGGAAGCAAATAGCAGCTCAGGAAATCCCACGGTTGACT 
               
               
                 TGCCTTGATGGCAAGCTTGGTGGAGAGGGCTGAAGCTGTTGCTGGGGGCCGATTCTG 
               
               
                 ATCAAGACACATGGCTTGAAAATGGAAGACACAAAACTGAGAGATCATTCTGCACT 
               
               
                 AAGTTTCGGGAACTTATCCCCGACAGTGACTGAACTCACTGACTAATAACTTCATTT 
               
               
                 ATGAATCTTCTCACTTGTCCCTTTGTCTGCCAACCTGTGTGCCTTTTTTGTAAAACATT 
               
               
                 TTCATGTCTTTAAAATGCCTGTTGAATACCTGGAGTTTAGTATCAACTTCTACACAGA 
               
               
                 TAAGCTTTCAAAGTTGACAAACTTTTTTGACTCTTTCTGGAAAAGGGAAAGAAAATA 
               
               
                 GTCTTCCTTCTTTCTTGGGCAATATCCTTCACTTTACTACAGTTACTTTTGCAAACAG 
               
               
                 ACAGAAAGGATACACTTCTAACCACATTTTACTTCCTTCCCCTGTTGTCCAGTCCAAC 
               
               
                 TCCACAGTCACTCTTAAAACTTCTCTCTGTTTGCCTGCCTCCAACAGTACTTTTAACT 
               
               
                 TTTTGCTGTAAACAGAATAAAATTGAACAAATTAGGGGGTAGAAAGGAGCAGTGGT 
               
               
                 GTCGTTCACCGTGAGAGTCTGCATAGAACTCAGCAGTGTGCCCTGCTGTGTCTTGGA 
               
               
                 CCCTGCCCCCCACAGGAGTTGTACAGTCCCTGGCCCTGTTCCCTACCTCCTCTCTTCA 
               
               
                 CCCCGTTAGGCTGTTTTCAATGTAATGCTGCCGTCCTTCTCTTGCACTGCCTTCTGCG 
               
               
                 CTAACACCTCCATTCCTGTTTATAACCGTGTATTTATTACTTAATGTATATAATGTAA 
               
               
                 TGTTTTGTAAGTTATTAATTTATATATCTAACATTGCCTGCCAATGGTGGTGTTAAAT 
               
               
                 TTGTGTAGAAAACTCTGCCTAAGAGTTACGACTTTTTCTTGTAATGTTTTGTATTGTG 
               
               
                 TATTATATAACCCAAACGTCACTTAGTAGAGACATATGGCCCCCTTGGCAGAGAGGA 
               
               
                 CAGGGGTGGGCTTTTGTTCAAAGGGTCTGCCCTTTCCCTGCCTGAGTTGCTACTTCTG 
               
               
                 CACAACCCCTTTATGAACCAGTTTTGGAAACAATATTCTCACATTAGATACTAAATG 
               
               
                 GTTTATACTGAGCTTTTACTTTTGTATAGCTTGATAGGGGCAGGGGGCAATGGGATG 
               
               
                 TAGTTTTTACCCAGGTTCTATCCAAATCTATGTGGGCATGAGTTGGGTTATAACTGG 
               
               
                 ATCCTACTATCATTGTGGCTTTGGTTCAAAAGGAAACACTACATTTGCTCACAGATG 
               
               
                 ATTCTTCTGAATGCTCCCGAACTACTGACTTTGAAGAGGTAGCCTCCTGCCTGCCATT 
               
               
                 AAGCAGGAATGTCATGTTCCAGTTCATTACAAAAGAAAACAATAAAACAATGTGAA 
               
               
                 TTTTTATAATAAAATGTGAACTGATGTAGCAAATTACGCAAATGTGAAGCCTCTTCT 
               
               
                 GATAACACTTGTTAGGCCTCTTACTGATGTCAGTTTCAGTTTGTAAAATATGTTTCAT 
               
               
                 GCTTTCAGTTCAGCATTGTGACTCAGTAATTACAGAAAATGGCACAAATGTGCATGA 
               
               
                 CCAATGTATGTCTATGAACACTGCATTGTTTCAGGTGGACATTTTATCATTTTCAAAT 
               
               
                 GTTTCTCACAATGTATGTTATAGTATTATTATTATATATTGTGTTCAAATGCATTCTA 
               
               
                 AAGAGACTTTTATATGAGGTGAATAAAGAAAAGCATGATTAGATTAAAAAAA 
               
               
                   
               
               
                 SCARB1 (SEQ ID NO: 27; NM_005505.4). 
               
               
                 GCTCAGGCCCCGCCCCTGCCGCCGGAATCCTGAAGCCCAAGGCTGCCCGGGGGCGG 
               
               
                 TCCGGCGGCGCCGGCGATGGGGCATAAAACCACTGGCCACCTGCCGGGCTGCTCCT 
               
               
                 GCGTGCGCTGCCGTCCCGGATCCACCGTGCCTCTGCGGCCTGCGTGCCCGGAGTCCC 
               
               
                 CGCCTGTGTCGTCTCTGTCGCCGTCCCCGTCTCCTGCCAGGCGCGGAGCCCTGCGAG 
               
               
                 CCGCGGGTGGGCCCCAGGCGCGCAGACATGGGCTGCTCCGCCAAAGCGCGCTGGGC 
               
               
                 TGCCGGGGCGCTGGGCGTCGCGGGGCTACTGTGCGCTGTGCTGGGCGCTGTCATGAT 
               
               
                 CGTGATGGTGCCGTCGCTCATCAAGCAGCAGGTCCTTAAGAACGTGCGCATCGACCC 
               
               
                 CAGTAGCCTGTCCTTCAACATGTGGAAGGAGATCCCTATCCCCTTCTATCTCTCCGTC 
               
               
                 TACTTCTTTGACGTCATGAACCCCAGCGAGATCCTGAAGGGCGAGAAGCCGCAGGT 
               
               
                 GCGGGAGCGCGGGCCCTACGTGTACAGGGAGTTCAGGCACAAAAGCAACATCACCT 
               
               
                 TCAACAACAACGACACCGTGTCCTTCCTCGAGTACCGCACCTTCCAGTTCCAGCCCT 
               
               
                 CCAAGTCCCACGGCTCGGAGAGCGACTACATCGTCATGCCCAACATCCTGGTCTTGG 
               
               
                 GTGCGGCGGTGATGATGGAGAATAAGCCCATGACCCTGAAGCTCATCATGACCTTG 
               
               
                 GCATTCACCACCCTCGGCGAACGTGCCTTCATGAACCGCACTGTGGGTGAGATCATG 
               
               
                 TGGGGCTACAAGGACCCCCTTGTGAATCTCATCAACAAGTACTTTCCAGGCATGTTC 
               
               
                 CCCTTCAAGGACAAGTTCGGATTATTTGCTGAGCTCAACAACTCCGACTCTGGGCTC 
               
               
                 TTCACGGTGTTCACGGGGGTCCAGAACATCAGCAGGATCCACCTCGTGGACAAGTG 
               
               
                 GAACGGGCTGAGCAAGGTTGACTTCTGGCATTCCGATCAGTGCAACATGATCAATG 
               
               
                 GAACTTCTGGGCAAATGTGGCCGCCCTTCATGACTCCTGAGTCCTCGCTGGAGTTCT 
               
               
                 ACAGCCCGGAGGCCTGCCGATCCATGAAGCTAATGTACAAGGAGTCAGGGGTGTTT 
               
               
                 GAAGGCATCCCCACCTATCGCTTCGTGGCTCCCAAAACCCTGTTTGCCAACGGGTCC 
               
               
                 ATCTACCCACCCAACGAAGGCTTCTGCCCGTGCCTGGAGTCTGGAATTCAGAACGTC 
               
               
                 AGCACCTGCAGGTTCAGTGCCCCCTTGTTTCTCTCCCATCCTCACTTCCTCAACGCTG 
               
               
                 ACCCGGTTCTGGCAGAAGCGGTGACTGGCCTGCACCCTAACCAGGAGGCACACTCC 
               
               
                 TTGTTCCTGGACATCCACCCGGTCACGGGAATCCCCATGAACTGCTCTGTGAAACTG 
               
               
                 CAGCTGAGCCTCTACATGAAATCTGTCGCAGGCATTGGACAAACTGGGAAGATTGA 
               
               
                 GCCTGTGGTCCTGCCGCTGCTCTGGTTTGCAGAGAGCGGGGCCATGGAGGGGGAGA 
               
               
                 CTCTTCACACATTCTACACTCAGCTGGTGTTGATGCCCAAGGTGATGCACTATGCCC 
               
               
                 AGTACGTCCTCCTGGCGCTGGGCTGCGTCCTGCTGCTGGTCCCTGTCATCTGCCAAA 
               
               
                 TCCGGAGCCAAGAGAAATGCTATTTATTTTGGAGTAGTAGTAAAAAGGGCTCAAAG 
               
               
                 GATAAGGAGGCCATTCAGGCCTATTCTGAATCCCTGATGACATCAGCTCCCAAGGGC 
               
               
                 TCTGTGCTGCAGGAAGCAAAACTGTAGGGTCCTGAGGACACCGTGAGCCAGCCAGG 
               
               
                 CCTGGCCGCTGGGCCTGACCGGCCCCCCAGCCCCTACACCCCGCTTCTCCCGGACTC 
               
               
                 TCCCAGCGGACAGCCCCCCAGCCCCACAGCCTGAGCCTCCCAGCTGCCATGTGCCTG 
               
               
                 TTGCACACCTGCACACACGCCCTGGCACACATACACACATGCGTGCAGGCTTGTGCA 
               
               
                 GACACTCAGGGATGGAGCTGCTGCTGAAGGGACTTGTAGGGAGAGGCTCGTCAACA 
               
               
                 AGCACTGTTCTGGAACCTTCTCTCCACGTGGCCCACAGGCCTGACCACAGGGGCTGT 
               
               
                 GGGTCCTGCGTCCCCTTCCTCGGGTGAGCCTGGCCTGTCCCGTTCAGCCGTTGGGCC 
               
               
                 CAGGCTTCCTCCCCTCCAAGGTGAAACACTGCAGTCCCGGTGTGGTGGCTCCCCATG 
               
               
                 CAGGACGGGCCAGGCTGGGAGTGCCGCCTTCCTGTGCCAAATTCAGTGGGGACTCA 
               
               
                 GTGCCCAGGCCCTGGCCACGAGCTTTGGCCTTGGTCTACCTGCCAGGCCAGGCAAAG 
               
               
                 CGCCTTTACACAGGCCTCGGAAAACAATGGAGTGAGCACAAGATGCCCTGTGCAGC 
               
               
                 TGCCCGAGGGTCTCCGCCCACCCCGGCCGGACTTTGATCCCCCCGAAGTCTTCACAG 
               
               
                 GCACTGCATCGGGTTGTCTGGCGCCCTTTTCCTCCAGCCTAAACTGACATCATCCTAT 
               
               
                 GGACTGAGCCGGCCACTCTCTGGCCGAAGTGGCCGCAGGCTGTGCCCCCGAGCTGC 
               
               
                 CCCCACCCCCTCACAGGGTCCCTCAGATTATAGGTGCCCAGGCTGAGGTGAAGAGG 
               
               
                 CCTGGGGGCCCTGCCTTCCGGGCGCTCCTGGACCCTGGGGCAAACCTGTGACCCTTT 
               
               
                 TCTACTGGAATAGAAATGAGTTTTATCATCTTTGAAAAATAATTCACTCTTGAAGTA 
               
               
                 ATAAACGTTTAAAAAAATGGGAAAAAAAAAAAAAAAAAA 
               
               
                   
               
               
                 TMEM9B (SEQ ID NO: 28; NM_020644.2). 
               
               
                 GTGCGCGAACGGCTCCGGCCCGCACGGGTCGCCAGAGGCGACTGTGTGACACTCGG 
               
               
                 AGTTTGCTGGGGTCTCCGTGGGCGGGAGGACTTTCCAGCGCAATGGCGACTCCCTAA 
               
               
                 GCCCCGCAGCTTCTGCGCCCGGGAAAGATATCCAAGAGATGCAAAGCTCTACTGGG 
               
               
                 CCCAGGCTGCCACCCCAGAGGCCCCCTTCCGTCCCGGGGCCGGGGCTAGGCCAAGG 
               
               
                 CGGGCACCAGGACTGCCCAGCCTCCCGGCCCTTCGCACTGGTAACCGGTTCCGGGGC 
               
               
                 GGATGCTTTTTGCATCTGACCCGGCGCGCCCGGTGACGCCTTCGCGTCCAGACGGAA 
               
               
                 GTGCGGGCGGAGGATCCCCAGCCGGGTCCCAAGCCTGTGCCTGAGCCTGAGCCTGA 
               
               
                 GCCTGAGCCCGAGCCGGGAGCCGGTCGCGGGGGCTCCGGGCTGTGGGACCGCTGGG 
               
               
                 CCCCCAGCGATGGCGACCCTGTGGGGAGGCCTTCTTCGGCTTGGCTCCTTGCTCAGC 
               
               
                 CTGTCGTGCCTGGCGCTTTCCGTGCTGCTGCTGGCGCAGCTGTCAGACGCCGCCAAG 
               
               
                 AATTTCGAGGATGTCAGATGTAAATGTATCTGCCCTCCCTATAAAGAAAATTCTGGG 
               
               
                 CATATTTATAATAAGAACATATCTCAGAAAGATTGTGATTGCCTTCATGTTGTGGAG 
               
               
                 CCCATGCCTGTGCGGGGGCCTGATGTAGAAGCATACTGTCTACGCTGTGAATGCAAA 
               
               
                 TATGAAGAAAGAAGCTCTGTCACAATCAAGGTTACCATTATAATTTATCTCTCCATT 
               
               
                 TTGGGCCTTCTACTTCTGTACATGGTATATCTTACTCTGGTTGAGCCCATACTGAAGA 
               
               
                 GGCGCCTCTTTGGACATGCACAGTTGATACAGAGTGATGATGATATTGGGGATCACC 
               
               
                 AGCCTTTTGCAAATGCACACGATGTGCTAGCCCGCTCCCGCAGTCGAGCCAACGTGC 
               
               
                 TGAACAAGGTAGAATATGCACAGCAGCGCTGGAAGCTTCAAGTCCAAGAGCAGCGA 
               
               
                 AAGTCTGTCTTTGACCGGCATGTTGTCCTCAGCTAATTGGGAATTGAATTCAAGGTG 
               
               
                 ACTAGAAAGAAACAGGCAGACAACTGGAAAGAACTGACTGGGTTTTGCTGGGTTTC 
               
               
                 ATTTTAATACCTTGTTGATTTCACCAACTGTTGCTGGAAGATTCAAAACTGGAAGCA 
               
               
                 AAAACTTGCTTGATTTTTTTTTCTTGTTAACGTAATAATAGAGACATTTTTAAAAGCA 
               
               
                 CACAGCTCAAAGTCAGCCAATAAGTCTTTTCCTATTTGTGACTTTTACTAATAAAAAT 
               
               
                 AAATCTGCCTGTAAATTATCTTGAAGTCCTTTACCTGGAACAAGCACTCTCTTTTTCA 
               
               
                 CCACATAGTTTTAACTTGACTTTCAAGATAATTTTCAGGGTTTTTGTTGTTGTTGTTTT 
               
               
                 TTGTTTGTTTGTTTTGGTGGGAGAGGGGAGGGATGCCTGGGAAGTGGTTAACAACTT 
               
               
                 TTTTCAAGTCACTTTACTAAACAAACTTTTGTAAATAGACCTTACCTTCTATTTTCGA 
               
               
                 GTTTCATTTATATTTTGCAGTGTAGCCAGCCTCATCAAAGAGCTGACTTACTCATTTG 
               
               
                 ACTTTTGCACTGACTGTATTATCTGGGTATCTGCTGTGTCTGCACTTCATGGTAAACG 
               
               
                 GGATCTAAAATGCCTGGTGGCTTTTCACAAAAAGCAGATTTTCTTCATGTACTGTGA 
               
               
                 TGTCTGATGCAATGCATCCTAGAACAAACTGGCCATTTGCTAGTTTACTCTAAAGAC 
               
               
                 TAAACATAGTCTTGGTGTGTGTGGTCTTACTCATCTTCTAGTACCTTTAAGGACAAAT 
               
               
                 CCTAAGGACTTGGACACTTGCAATAAAGAAATTTTATTTTAAACCCAAGCCTCCCTG 
               
               
                 GATTGATAATATATACACATTTGTCAGCATTTCCGGTCGTGGTGAGAGGCAGCTGTT 
               
               
                 TGAGCTCCAATGTGTGCAGCTTTGAACTAGGGCTGGGGTTGTGGGTGCCTCTTCTGA 
               
               
                 AAGGTCTAACCATTATTGGATAACTGGCTTTTTTCTTCCTATGTCCTCTTTGGAATGT 
               
               
                 AACAATAAAAATAATTTTTGAAACATCCATCAGTGTATCTATCTATGTCTCCTAGTTT 
               
               
                 TTTCCTCCTCCCTCTTTTGCTGTATAATGAGATTGAAGATATAAAGACATTTTGTACC 
               
               
                 CTGTAAAAAAAA 
               
               
                   
               
               
                 PPP6R3 (SEQ ID NO: 29; XM_005274081). 
               
               
                 AACTCAAGGCCTGCTTGATACGTCCGCCATTTTGGGCGCTTCGCTGATGGTGTCGGT 
               
               
                 GAGCGCGTTTCCCGCCTGAGCGCAACTAGCGGCGGGTCGTGGGCACCTCCAGGAGA 
               
               
                 GCTTGTTTCATATCCATATCCCACTGTATTCCTGCTAATCTGCTAATGCAGTAAATTG 
               
               
                 GAGGAAAACTGTTACCAGGATAACCTGTAATGGGCAAGGAGCCACAAAGAAGAAA 
               
               
                 ACATTTCTTTTAATTTTTAAACTTGGTTTGAAAGACCAGCATGTTTTGGAAATTTGAT 
               
               
                 CTTCACTCATCATCCCACATAGACACACTTCTAGAAAGAGAAGATGTAACACTGAAG 
               
               
                 GAGTTAATGGATGAGGAAGATGTTTTACAGGAATGTAAAGCTCAGAACCGCAAACT 
               
               
                 TATAGAGTTTCTGTTAAAAGCAGAATGTCTCGAAGATTTAGTCTCATTCATTATAGA 
               
               
                 AGAACCACCTCAAGACATGGATGAAAAGATCAGATACAAGTATCCAAATATATCTT 
               
               
                 GTGAGTTGCTCACTTCTGATGTCTCCCAGATGAATGATAGACTGGGAGAAGATGAAT 
               
               
                 CCTTGCTAATGAAATTATATAGCTTCCTCCTAAACGATTCCCCTTTGAATCCACTACT 
               
               
                 TGCCAGTTTCTTCAGCAAGGTGCTAAGTATTCTTATCAGCAGAAAACCAGAACAGAT 
               
               
                 TGTGGATTTCTTAAAGAAGAAGCATGATTTTGTAGACCTTATTATAAAGCACATAGG 
               
               
                 AACTTCTGCTATCATGGATTTGTTGCTCAGGCTCCTGACGTGTATCGAACCTCCACAG 
               
               
                 CCCAGGCAAGATGTGCTGAATTGGTTAAATGAGGAGAAAATTATCCAGAGGCTTGT 
               
               
                 GGAAATAGTTCATCCATCGCAAGAAGAAGATCGACATTCAAATGCATCACAATCAC 
               
               
                 TTTGTGAAATTGTTCGCCTGAGCAGAGACCAGATGTTACAAATTCAGAACAGTACAG 
               
               
                 AGCCCGACCCCCTGCTTGCCACTCTAGAAAAGCAAGAAATTATAGAGCAGCTTCTAT 
               
               
                 CAAATATTTTCCACAAGGAGAAAAATGAGTCAGCCATAGTCAGTGCAATCCAGATA 
               
               
                 TTGCTGACTTTACTTGAGACACGACGACCAACATTTGAAGGCCATATAGAGATCTGC 
               
               
                 CCACCAGGCATGAGCCATTCAGCTTGTTCAGTAAACAAGAGTGTTCTAGAAGCCATC 
               
               
                 AGAGGAAGACTTGGATCTTTTCATGAACTCCTGCTGGAGCCACCCAAGAAAAGTGT 
               
               
                 GATGAAGACCACATGGGGTGTGCTGGATCCTCCTGTGGGGAATACCCGGTTGAATGT 
               
               
                 CATTAGGTTGATATCCAGCCTGCTTCAAACCAATACCAGCAGTATAAATGGGGACCT 
               
               
                 TATGGAGCTGAATAGCATTGGAGTCATATTGAACATGTTCTTCAAGTATACATGGAA 
               
               
                 TAACTTTTTGCATACACAAGTGGAAATTTGTATTGCACTGATTCTTGCAAGTCCTTTT 
               
               
                 GAAAACACAGAAAATGCCACAATTACCGATCAAGACTCCACTGGTGATAATTTGTT 
               
               
                 ATTAAAACATCTTTTCCAAAAATGTCAATTAATAGAACGAATACTTGAAGCCTGGGA 
               
               
                 AATGAATGAGAAGAAACAGGCTGAGGGAGGAAGACGGCATGGTTACATGGGACAC 
               
               
                 CTAACGAGGATAGCTAACTGTATCGTGCACAGCACTGACAAGGGCCCCAACAGTGC 
               
               
                 ATTAGTGCAGCAGCTTATCAAAGATCTTCCCGACGAAGTCAGGGAACGATGGGAGA 
               
               
                 CGTTCTGCACAAGCTCCTTAGGAGAAACTAACAAGAGGAACACGGTAGATCTAGTT 
               
               
                 ACAACCTGCCATATTCATTCATCCAGTGATGATGAAATTGACTTTAAAGAAACGGGT 
               
               
                 TTCTCACAGGATTCTTCTTTGCAGCAAGCCTTTTCTGATTATCAGATGCAACAAATGA 
               
               
                 CGTCCAATTTTATTGACCAGTTTGGCTTCAACGATGAGAAGTTTGCAGATCAAGATG 
               
               
                 ACATTGGCAATGTTTCTTTTGATCGAGTATCAGACATCAACTTTACTCTCAATACAAA 
               
               
                 TGAAAGTGGAAATATTGCCTTGTTTGAAGCATGTTGTAAGGAAAGAATACAACAGTT 
               
               
                 TGATGATGGTGGCTCTGATGAGGAAGATATATGGGAGGAAAAGCACATCGCATTCA 
               
               
                 CACCAGAATCCCAAAGACGATCCAGCTCGGGGAGTACAGACAGTGAGGAAAGTAC 
               
               
                 AGACTCTGAAGAAGAAGATGGAGCAAAGCAAGACTTGTTTGAACCCAGCAGTGCCA 
               
               
                 ACACGGAGGATAAAATGGAGGTGGACCTGAGTGAACCACCCAACTGGTCAGCTAAC 
               
               
                 TTTGATGTCCCAATGGAAACAACCCACGGTGCTCCATTGGATTCTGTGGGATCTGAT 
               
               
                 GTCTGGAGCACAGAGGAGCCGATGCCAACTAAAGAGACGGGCTGGGCTTCTTTTTC 
               
               
                 AGAGTTCACGTCTTCCCTGAGCACAAAAGATTCTTTAAGGAGTAATTCTCCAGTGGA 
               
               
                 AATGGAAACCAGCACTGAACCCATGGACCCTCTGACTCCCAGTGCGGCTGCCCTGG 
               
               
                 CAGTGCAGCCAGAAGCGGCAGGCAGTGTGGCCATGGAAGCCAGCTCTGACGGAGA 
               
               
                 GGAGGATGCAGAAAGTACAGACAAGGTAACTGAGACAGTGATGAATGGCGGCATG 
               
               
                 AAGGAAACGCTCAGCCTCACTGTAGATGCCAAGACAGAGACTGCGGTCTTCAAAAG 
               
               
                 TGAGGAAGGGAAACTGTCTACCTCTCAAGATGCTGCTTGTAAAGACGCAGAGGAGT 
               
               
                 GTCCCGAGACTGCAGAGGCGAAGTGCGCGGCGCCCAGGCCTCCCAGCAGCAGTCCC 
               
               
                 GAGCAGAGTGCCTCCGATGCCTGTCTGTTGCTCCTTAGGACTGGCCAACCAAGCGCA 
               
               
                 CCAGGTGACACTTCAGTGAATGGCCCTGTATGACGGGTGACGTCTGCTGCTGCTGAC 
               
               
                 TGAGGACTGCAGACCGCCACCACTCAGGGGCTCTGGAGGGGTCAGCTGGAGCCCAC 
               
               
                 CAAGCTGTCACTGCTGCACTCACTCTGCAAGGGATCAGGACCAGCAACCTTTATATT 
               
               
                 CTAGATTCTAAGACATTGTACAGAGAAATTCAGAAGTGTAAAAATATTGCACATTGA 
               
               
                 CAAATACCAAGAATTTTTGCGTATGTTTATATTGTATTGTTCTAAATAATGGGTAGCC 
               
               
                 TGTGAAATAAGATCTTGCCACCCATGTAATAATAGTAGTAATACTATAGTTAAAATG 
               
               
                 GCTGTAAGAATAGTTTTATAAAAGTGAATACACAGATCTATTGTATTTGAAACATAA 
               
               
                 CTTTGACAATTATTAGTGTGACCAAAGTATTAGGCGGTTTTCATACATTTTTCACCTT 
               
               
                 GTACAAAATTATGAATTCATTTTTCCTCCAGGCCGACAAGGAGTTGTAGAATGAAAA 
               
               
                 TGCCCTCTAAGTGTTATTTTGGTTGTTCTAACTTACAAAAGTGATTTTGAATAAGAAA 
               
               
                 TATTTGGTGTTCTTTTTATAACCAGTTTTTGATTGGTAATTGTTTTCTGTATTGTTTAA 
               
               
                 AACGGATCAAAAATGTAAGTCTATTGGTAGAGATTAAGTAAAGTATTTATTGCTACA 
               
               
                 TCATAGTTGATAAATTGATGTTATCGTAAAGCCATATGTTCTGTTCAAGTCTTGTTTG 
               
               
                 CTTGAAATGATTATTCCTACAAGTGAAACACTAGACTATTTGGAGTGTATATGGCTT 
               
               
                 GTGTTTTGGGATTTTTTTTTTTTTTTTTTGGCTTTTGTTTTTGTTTGTTTTTTTGTTTCAT 
               
               
                 TTGGTAGTTCATCTGCCTTTTAACCCATTCACCAAAATTTACCTTGTTAACAAGCATC 
               
               
                 ACCAATGAACATTTCAGAGCAATCTGCATATTTAACAGACCTAAAATAAATCCTATT 
               
               
                 AGGCAAGTCAGTTGAAAATGCTCGTGCTGCTAATGGAATTAGAGTGCGTTCATTTTA 
               
               
                 CAGGCTAGTATTTTAAAAGTAGAAATCAAAATCTGGCACCGAAGCATGCTAATTGTT 
               
               
                 TACTGTACCTTGTGAGGTTTTCACTCATAAATTTAAACCAGTGTATTTTTTTAGAACT 
               
               
                 GGTTTGTGTATATATATAGTGATTATGGATACTAATTCAATGTAATTTATAATTTTCT 
               
               
                 ATGTCAATACAAAAATACATCACAGCCTTCTCAAACAGCTCAAGCAATATATTGTAT 
               
               
                 ATTGCCATATCGTCTGGTGAAAGGGTTAAATTACTTCACCTCTTGCACTTTTAGATGC 
               
               
                 AAATCAGTTTTTCATTTCTGTAATAGAAAATTATTCACGTATTTTTACATCATTTGTTT 
               
               
                 TTCCTGACCAGTATTTAAAACCAAAAGGATATTCTGAAAAATGGCCAACAATTTTTT 
               
               
                 TAGAAGTAGCATCCCAAGCAGCGTGCCTAAACATTACATTGCATATGGAAATAAAA 
               
               
                 GAATCAAACGTCTAATGCCTTATTATTTCTGATTTCCTTTTTCATTTTAAGTGGTGTG 
               
               
                 GAGATTCCAGCACTCCCAGGACAGTGGAGTCAGCAGTAAGCCCTGGGACAGGTGGC 
               
               
                 AAGGGTGGGTCCCTTGACCTTTGCACGCCTCCTCAGGAACCCCCTTTCCCGGGTGAG 
               
               
                 CCCCTCTCTGAAGAGACTGTCCTTGGGCCTCCTCTGGAAGCAGCACCCCCAGAGGAC 
               
               
                 AGGGCTCCTCCTGCTTGCCTCAGGGCTGCCTGACTTGAATGGCGTTGGACCTCGGGG 
               
               
                 ATTACTGGTAGATAATATGCTCTGGTCTCGCCTGGTGGTGAGTTTTGCCAGCCATGG 
               
               
                 CCAGGGTTTGGCTCCACTGGTGGCACACGTGGCCTCCGTGGTATGGACCTGGTGGCT 
               
               
                 TCTCCATCCCACTGTGGCCTCTGTGGTATGGACCTGGTGGCTTCTCCATCCTACCCAA 
               
               
                 GGTAACAGTGTCTTGCTTCATCCCACTGACTGCTGGGAGAGAGCCTCTGGGACTTTT 
               
               
                 CTTTGGGGCATCATTTTGTTTTGTCTTTCGTAGCAGGGAAAGGATATGACAATGGGG 
               
               
                 AGGACAGTTCTTTTGGAGGTTGGAGGGGCCAAGCCAAGGACAGGAGCAAGTGTGCC 
               
               
                 CTCATTTTGTTTCTACTTTTAATTTCTGTGTGTTGGCCATACTGAATTATGAGACTAA 
               
               
                 CAGATGTCTACAATACAATACCTGTATTCAAAATAACAAAAATAAAGCCTGATTCTT 
               
               
                 TGTTTCTAGAAA