Abstract:
The reaction of a samarium catalyst [η 5  --(CH 3 ) 5  C 5  ] 2  Sm(THF) 2  with amino-olefins provides a straightforward route to a heterocyclic compound. Alternatively, the reaction of olefins with the samarium catalyst in the presence of an amine results in an aminoalkane.

Description:
This application is a continuation-in-part of application Ser. No. 291,186, filed Dec. 28, 1988, now abandoned, by Marks and Gagne, entitled &#34;Method for Hydroaminating Olefins.&#34; 
    
    
     This application relates to catalysts and more particularly to a method for the hydroamination of olefins through the use of organosamarium catalysts. 
     BACKGROUND OF THE INVENTION 
     The catalytic addition of N-H bonds to olefins (eq.(I)) to yield amines is a process of potentially great technological importance. ##STR1## However, presently known catalyst systems, employing palladium, platinum, or alkali metal catalysts, can be relatively inefficient, having very low rates, poor catalyst lifetimes, poor selectivities, or requiring initial modification of the amine--e.g., tosylation. As a result, many current catalytic processes involve the conversion of alcohols to amines with the alcohol, which in turn, is prepared from the olefin. Such hydroamination reactions are exothermic, yet thus far have proven difficult to perform due to a lack of suitable catalysts and, to a lesser extent, unfavorable entropy effects. As a result, more attention has been paid to aminating olefins intramolecularly, and limited successes have been experienced in both stoichiometric and catalytic type reactions. A rapid efficient, direct process for the hydroamination of olefins would be beneficial. 
     Organolanthanide catalysts have been found useful as noted in U.S. Pat. No. 4,668,773 to Marks and Mauermann, the organolanthanide complexes [η 5  --(CH 3 ) 5  C 5  ] 2  MCl 2  --Li](C 2  H 5 ) 2  O] 2   + , M=La, Nd, Sm, Lu, with LiCH[Si(CH 3 ) 3  ] 2  were shown to provide a straight-forward route to ether-free and halide-free bis(pentamethylcyclopentadienyl) lanthanide alkyls [η 5  (CH 3 ) 5  C 5]   ]   2  MCH[Si(CH 3 ) 3  ] 2 . Such [η 5  (CH 3 ) 5  C 5  ] 2  MCH[Si(CH 3 ) 3  ] 2  complexes react with H: under mild conditions to yield the corresponding hydrides [η 5  (CH 3 ) 5  (C 5 ) 2  MH[ 2 . These complexes have been found to be extremely active homogeneous olefin polymerization catalysts, as well as catalysts for olefin and acetylene hydrogenation. 
     SUMMARY OF THE INVENTION 
     Therefore, an object of the subject invention is the use of organolanthanide catalysts for use in hydroamination reactions. 
     Another object of the subject invention is a shelf-stable environmentally acceptable organolanthanide catalyst and its use in a method for the hydroamination of olefins. 
     A further object of the subject application is a method for the synthesis of an organosamarium catalyst and the use of the organosamarium catalyst to hydroaminate amino-olefins. 
     These and other objects are attained in accordance with the subject invention wherein Cp&#39; 2  Sm(THF) 2  and Cp&#39; 2  Sm (Cp&#39;=η 5  --R 5  C 5 , R=H, an alkyl or aryl group or any mixture thereof; THF=tetrahydrofuran), and more particularly bis(pentamethylcyclopentadienyl) samarium bis(tetrahydrofuran) are prepared as effective catalyst precursors for the hydroamination of olefins. The procedure of the subject invention comprises the oxidative addition of the amino-olefin to the catalyst, forming in the process one equivalent of samarium-allyl and one equivalent of samarium-hydride. These equivalents can further react in a second step with the amino-olefin to yield the catalytically active, known samarium-amido species. This species further reacts, via an olefin insertion, into Sm--N bond and a protonation step to yield the cyclized amine and to regenerate the active catalyst. Cp&#39; 2  Sm(THF) 2  and its related entity Cp&#39; 2  Sm have the distinct advantage of not only being an efficient catalytic agent, but also they are extremely easily prepared. 
     These and other objects of the subject invention, together with additional features contributing thereto and advantages occurring therefore will be apparent from the following description of one embodiment of the invention when read in conjunction with the accompanying drawing wherein: 
     The figure is a representation of the reaction pathway of the method of the subject invention. 
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
     All operations were performed with rigorous exclusion of oxygen and moisture in flamed Schlenk-type glassware in a dual manifold Schlenk line or interfaced to a high vacuum (10 -5  torr) system, or in a nitrogen or argon filled glovebox with a high capacity atmosphere recirculator. Argon, ethylene, propylene, dihydrogen, and deuterium gas were purified by passage through a supported MnO oxygen removal column and a molecular sieve column. Aliphatic hydrocarbon solvents were pretreated with concentrated H 2  SO 4 , KMnO 4  solution, MgSo 4 , and Na, 4Å molecular sieves. All reaction solvents were distilled from Na/K/benzophenone under nitrogen and were condensed and stored in vacuo in bulbs on the vacuum line containing a small amount of [Ti(η 5  --C 5  H 5 ) 2  Cl] 2  ZnCl 2  as indicator. Cyclohexane and heptane were additionally vacuum transferred onto Na/K and stirred for at least a day before use in catalytic experiments. The olefins, all hexenes and cyclohexene, were purified by stirring over Na/K for at least 6 hours and were freshly vacuum transferred. The amines were purified by stirring over Na/K for 1/2 hour, followed by at least 3 successive vacuum transfers onto freshly activated 4Å molecular sieves (at least 1 day each); and freshly vacuum transferred before use. Deuterated solvents were dried over Na/K and vacuum transferred before use. Pentamethylcyclopentadiene was prepared by the procedure set forth in Oroanometallics. 1984, 3, 819-821. 
     I. Catalyst Syntheses 
     In general, the Cp&#39; 2  Sm(THF) 2  complex may be prepared in one simple step. 
     
          I.sub.2 Sm(THF).sub.2 +2KCp&#39;→Cp&#39;.sub.2 Sm(THF).sub.2 +2KI 
    
     II. Hydroamination 
     The anaerobic catalytic reaction of Cp&#39; 2  Sm(THF) 2  with a variety of dry, degassed amino olefins and alkenes (typically in 100-200-fold stoichiometric excess) proceeds to completion in hydrocarbon solvents such as benzene, toluene, cyclohexane, or pentane. The base-free adduct Cp&#39; 2  Sm may also be used as a catalyst with no significant difference in cyclization rates. The reactions may be conveniently monitored by NMR spectroscopy and the products may be identified by comparison with spectral data from the literature and/or with those of authentic samples. 
     By supplying olefins to the Sm--N bond intramolecularly in an organosamarium compound, it is possible to have a large effective concentration of olefin around the amine, while at the same time reducing the disfavoring entropic factor referred to above when the reaction is performed intermolecularly. 
     A. Synthesis of Heterocycles 
     To investigate one aspect of olefin hydroamination and in furtherance of one embodiment of the subject invention, a variety of cyclized amines may be synthesized from amino olefins, as set forth in Examples 1 through 6 below when reacted with catalytic amounts of an organosamarium catalyst, Cp&#39; 2  Sm(THF) 2 . The catalyst Cp&#39; 2  Sm(THF) 2  readily combines with olefins in a first step, thereby forming the expected organosamarium-allyl-complexes. The amido complexes all have the ability to intramolecularly insert an olefin into the resulting samarium-NHR bond. The insertion results in an alkyl complex which, in the presence of excess amine, is rapidly protonated, yielding an alkane, and reforming an amido compound. The combination of all the reactions set forth in the figure constitutes a catalytic cycle which demonstrates the key steps believed to be involved in forming a group of heterocyclic compounds. 
     The following examples demonstrate the versatility of the catalyst of the subject invention, showing the use of alkyl (Examples 1-8) aryl (Example 9) and hydrogen (Example 10) in Cp&#39;, as well as the use of Cp 2  Sm (Examples 7-8). 
     EXAMPLE 1 
     30 mg of [η 5  (CH 3 ) 5  C 5  ] 2  Sm in toluene was heated with 100 equivalents (350 mg) of 1-amino-4-pentene at 60° C. in a closed vessel under an inert atmosphere. After 2 days the reaction mixture was allowed to cool to room temperature and the volatiles were vacuum transferred into a second container. Analysis of the volatiles by standard analytical techniques give a determination of greater than 97% conversion to 2-methylpyrrolidine. 
     
                                           TABLE I__________________________________________________________________________ExampleStarting Amine   Product         Catalyst*__________________________________________________________________________ ##STR2##                  ##STR3##       Cp&#39;.sub.2 Sm(THF).sub.22 ##STR4##                  ##STR5##       Cp&#39;.sub.2 Sm(THF).sub.23 ##STR6##                  ##STR7##       Cp&#39;.sub.2 Sm(THF).sub.24 ##STR8##                  ##STR9##       Cp&#39;.sub.2 Sm(THF).sub.25 ##STR10##                  ##STR11##      Cp&#39;.sub.2 Sm(THF).sub.26 ##STR12##                  ##STR13##      Cp&#39; .sub.2 Sm(THF).sub.27 ##STR14##                  ##STR15##      Cp&#39;.sub.2 Sm8 ##STR16##                  ##STR17##      Cp&#39;.sub.2 Sm__________________________________________________________________________ *Cp&#39; = η.sup.5 (CH.sub.3).sub.5 C.sub.5 
    
     EXAMPLE 9 
     30 mg of bis(pentabenzylcyclopentadienyl) samarium (II) bis(tetrahydrofuran) (Cp.increment. 2  Sm(THF) 2 ) in toluene is heated with 100 equivalents of 1-amino-4-pentene at 60° C. in a closed vessel under an inert atmosphere. After two days the reaction mixture is allowed to cool to room temperature and the volatiles are vacuum transferred into a second container. 2-methylpyrrolidine is the resulting product. 
     EXAMPLE 10 
     30 mg of bis(cyclopentadienyl) samarium (II) bis(tetrahydrofuran) ((C 5  H 5 ) 2  Sm(THF) 2  or Cp&#39;&#39;&#39; 2  Sm(THF) 2 ) in toluene is heated with 100 equivalents of 1-amino-4-pentene at 60° C. in a closed vessel under an inert atmosphere. After two days the reaction mixture is allowed to cool to room temperature and the volatiles are vacuum transferred into a second container. 2-methylpyrrolidine is the resulting product. 
     By varying the amine one can also see a number of points, the most noticeable being the region specificity of the cyclizations. In each case, it is possible to insert the olefin in one of two orientations, hypothetically yielding the following structures with 1-amino-4-pentene as the amine: ##STR18## However, as is the case with 1-amino-4-pentene, and with the other amines, the smaller of the two possible ring sizes corresponding to lower ring strain in the transition state appears to be favored with no indication of side products. 
     As set forth above, 5-membered rings (e.g., Example 2) are formed much more readily than the corresponding 6-membered rings. The fact that six membered rints can be formed at all is noteworthy since this does not occur readily if at all with other catalytic systems. 
     By studying the kinetics of this process, one sees that the rate of appearance of cyclized product and hence the disappearance of he starting amine is linear with time, indicating zero order kinetics in the substrate. In the catalytic cycle, there are only two steps involved in the process, and since it is known that amine protonolysis of lanthanide-alkyls is rapid, the rate determining step should be the olefin-insertion into the lanthanide-N bond, indicating a sterically controlled process. 
     EXAMPLE 11 
     Cp&#39; 2  Sm is prepared from Cp&#39; 2  Sm(THF) 2  by vacuum sublimation. 30 mg of Cp&#39; 2  Sm in toluene was heated with 100 equivalents (350 mg) of 1-amino-4-pentene at 60° C. in a closed vessel under an inert atmosphere. After 2 days the reaction mixture was allowed to cool to room temperature and the volatiles were vacuum transferred into a second container. Analysis of the volatiles by standard analytical techniques showed greater than 97% conversion to 2-metylpyrrolidien. 
     B. Synthesis of Aminolakanes 
     In addition to synthesizing heterocycles through hydroamination, olefins, such as ethylene, propylene, butadiene, 1-butene, 1-hexene, 1,5hexadine, 1-heptene, and the like, can be hydroaminated with ammonia or other primary and secondary amines, such as R.increment.NH 2 , R.increment. 2  NH, where R.increment. can be an alkyl or aryl group. Hydroamination can be effected by stirring solutions of Cp&#39; 2  Sm or Cp&#39; 2  Sm (THF) 2  with the olefin under an ammonia atmosphere at various pressures. Cp.increment.Sm(THF) 2  or Cp&#39;&#39;&#39;Sm(THF) 2  may also be used. It is believed that most olefins an be hydroaminated provided that steric considerations are favorable and do not substantially impede the progress o the reaction. The solvents involved are as before. This process presumably involves ammonia or Ln--NH 2  at the insertion step, dependent on the amine source. 
     EXAMPLE 12 
     20 mg (48 μmol) of Cp&#39; 2  Sm is added to a reaction flask under a nitrogen atmosphere. The flask is connected to a high vacuum line and evacuated. 1-hexene which has been rigorously dried and degassed is then vacuum transferred onto the catalyst with stirring, the solution is then put under an atmosphere of ammonia. The reaction is monitored by the ammonia uptake. Once ammonia uptake has ceased, the solution is degassed, and the contents are then vacuum transferred to a second vessel. The result is 2-amino-hexane. 
     In general, it should be noted that the overall catalytic mechanism is sensitive to Lewis bases and Bronsted acids. Therefore, if hydroamination of materials that contain alcohols, thiols, carboxylic acids, for the like is required, protecting groups may be needed and can therefore be added as known in the art to inhibit the effect the interfering groups may have. 
     C. Heterogeneous Catalysis 
     In addition to the homogeneous catalytic synthetic methods described above, heterogeneous catalytic synthesis methods are envisioned as being within the cope of the subject invention as well. In such a heterogeneous process, the organolanthanide catalyst would be absorbed on the surface o the suitable inorganic substrate such as silica, silica gel, alumina, magnesium chloride, magnesium oxide or the like, and placed in contact with the reactants. 
     While the invention has been described switch reference to a preferred embodiment, it will be understood by those skilled in the art that various changes may be made and equivalents may be substituted for elements thereof without departing from the scope of the invention. In addition, many modifications may be made to adapt a particular situation or material to the teachings of the invention without departing from the essential scope thereof. Therefore, it is intended that the invention not be limited to the particular embodiment disclosed as the best mode contemplated for carrying out this invention, but that the invention will include all embodiments and equivalents falling within the scope of the appended claims. 
     Various features of the invention are set forth in the following claims.