Abstract:
Methods are provided of screening for age-related macular degeneration (AMD), including a risk of a subject devel - oping AMD or a risk of a subject progressing to an advanced fom of AMD. The methods can include analyzing a sample obtained from the subject for the presence of at least one single nucleotide polymorphism (SNP) selected from the group consisting of rs4711751, rs6982567, rs1999930, rs13278062, rs1912795, rs2270637, rs12040406, rs1367068, rs1079982, rs1443179, rs7720497, and/or rs6 1800454.

Description:
REFERENCE TO RELATED APPLICATIONS 
       [0001]    This application claims priority to and the benefit of U.S. Provisional Application No. 61/422,905, filed on Dec. 14, 2010; U.S. Provisional Application No. 61/444,482, filed on Feb. 18, 2011; and U.S. Provisional Application No. 61/529,817, filed on Aug. 31, 2011. The entire disclosure of each of the above-identified applications is incorporated by reference. 
     
    
     STATEMENT REGARDING FEDERALLY FUNDED RESEARCH 
       [0002]    This invention was made with government support under grant number RO1 EY11309 awarded by the National Institutes of Health and the National Eye Institute. The government has certain rights in the invention. 
     
    
     BACKGROUND 
       [0003]    Age-related macular degeneration (AMD) is the most common geriatric eye disorder leading to blindness. Macular degeneration is responsible for visual handicap in what is estimated conservatively to be approximately 16 million individuals worldwide. Among the elderly, the overall prevalence is estimated between 5.7% and 30% depending on the definition of early AMD, and its differentiation from features of normal aging, a distinction that remains poorly understood. 
         [0004]    Histopathologically, the hallmark of early neovascular AMD is accumulation of extracellular drusen and basal laminar deposit (abnormal material located between the plasma membrane and basal lamina of the retinal pigment epithelium) and basal linear deposit (material located between the basal lamina of the retinal pigment epithelium and the inner collageneous zone of Bruch&#39;s membrane). The end stage of AMD is characterized by a complete degeneration of the neurosensory retina and of the underlying retinal pigment epithelium in the macular area. Advanced stages of AMD can be subdivided into geographic atrophy and exudative AMD. Geographic atrophy is characterized by progressive atrophy of the retinal pigment epithelium. In exudative AMD the key phenomenon is the occurrence of choroidal neovascularisation (CNV). Eyes with CNV have varying degrees of reduced visual acuity, depending on location, size, type and age of the neovascular lesion. The development of choroidal neovascular membranes can be considered a late complication in the natural course of the disease possibly due to tissue disruption (Bruch&#39;s membrane) and decompensation of the underlying longstanding processes of AMD. 
         [0005]    Many pathophysiological aspects as well as vascular and environmental risk factors are associated with a progression of the disease. Family, twin, segregation, and case-control studies all suggested an involvement of genetic factors in the etiology of AMD prior to the discovery of various genes associated with AMD. 
         [0006]    Knowledge is growing about the extent of heritability, number of genes involved, and mechanisms underlying phenotypic heterogeneity. The search for genes and markers related to AMD faces challenges—onset is late in life, and there is usually only one generation available for studies. The parents of patients are often deceased, and their children are too young to manifest the disease. Generally, the heredity of late-onset diseases has been difficult to estimate because of the uncertainties of the diagnosis in previous generations and the inability to diagnose AMD among the children of an affected individual. Even in the absence of the ambiguities in the diagnosis of AMD in previous generations, the late onset of the condition itself, natural death rates, and small family sizes result in underestimation of genetic forms of AMD, and in overestimation of rates of sporadic disease. Moreover, the phenotypic variability is considerable, and it is conceivable that the currently used diagnostic entity of AMD in fact represents a spectrum of underlying conditions with various genetic and environmental factors involved. 
         [0007]    There remains a strong need for improved methods of diagnosing or prognosticating AMD or a susceptibility to AMD in subjects, as well as for evaluating and developing new methods of treatment. 
       SUMMARY 
       [0008]    The application relates, in part, to the identification of numerous genetic markers which are associated with the presence or progression of age-related macular degeneration (AMD) in an individual. More specifically, methods are provided for diagnosing a risk of an individual developing AMD or progressing to advanced forms of AMD (e.g., geographic atrophy and/or wet AMD) using these genetic markers. 
         [0009]    For example, in one aspect the invention provides a method of screening for age-related macular degeneration (AMD) in a human subject. The method can include determining a risk of AMD progression in the subject by analyzing a sample obtained from the subject for the presence in the subject&#39;s genome of at least one single nucleotide polymorphism (SNP) identified in Tables 3-10, or a proxy therefor. In some embodiments, a proxy is a marker that is in linkage disequilibrium with a particular SNP or marker of interest. The presence of a SNP indicates that the subject has an increased risk of developing AMD or developing an advanced form of AMD. The markers can be used individually or in combination when screening a subject. Preferred SNPs include, but are not limited to, rs4711751 (VEGF), rs1999930 (COL10A1/FRK), rs13278062 (TNFRSF10A), rs 1912795 (B3GALTL), rs2270637 (SLC18A1), rs6982567 (GDF6), rs12040406 and rs1367068 (CD55), rs1079982 (CARD10), rs1443179 (INTU), rs7720497 (ADAMTS16), and rs61800454 (TMCO1). In some embodiments, the presence of a particular SNP indicates the subject has an increased risk of developing AMD. In some embodiments, the presence of a particular SNP indicates the subject has an increased risk of developing an advanced form of AMD, such as geographic atrophy and/or wet AMD, which also is referred to as neovascular disease, choroidal neovascularisation (CNV), and exudative AMD. 
         [0010]    Various techniques can be used for analyzing a sample to determine the presence of a SNP in the subject&#39;s genome. For example, in some embodiments, the method of screening can include the steps of (i) combining a nucleic acid sample from the subject with one or more polynucleotide probes capable of hybridizing selectively to a particular SNP (e.g., any SNP identified in Tables 3-10) or gene allele, or a proxy therefor, and (ii) detecting the presence or absence of hybridization. The probes can be oligonucleotides capable of priming polynucleotide synthesis in an amplification reaction, such as PCR or real time PCR. In some embodiments, the presence of at least one SNP is determined using a microarray. In various embodiments, the presence of at least one SNP is determined by sequencing a portion of the patient&#39;s genome. 
         [0011]    In some embodiments, the patient is asymptomatic at the time of screening for AMD, and in some embodiments, the patient displays one or more AMD like symptoms at the time of screening. 
         [0012]    In some embodiments, the method includes detecting a haplotypes that includes a particular SNP (e.g., any SNP listed in Tables 3-10). 
         [0013]    In some embodiments, the method includes screening for a specific subtype of AMD, such as, for example, early AMD, geographic atrophy, wet AMD, neovascular disease, choroidal neovascularisation (CNV), exudative AMD, and combinations thereof. 
         [0014]    The invention also provides, in part, a diagnostic system. The diagnostic system can include an array of polynucleotides comprising one or more of SEQ ID NOS:1-15, or any reference sequences corresponding to the SNPs identified in Tables 2-10. The polynucleotides can include at least six or more contiguous nucleotides, and the polynucleotides can include an allelic polymorphism or SNP. The system also can include an array reader, an image processor, a database having AMD allelic data records and patient information records, a processor, and an information output. The system compiles and processes patient data and outputs information relating to the statistical probability of the patient developing AMD. 
         [0015]    The system can be used for various methods, including contacting a subject sample or portion thereof to the diagnostic array under high stringency hybridization conditions; inputting patient information into the system; and obtaining from the system information relating to the statistical probability of the patient developing AMD. 
         [0016]    Further provided are methods for diagnosing risk of AMD or severe forms of AMD in a human subject. The method includes combining genetic risk with behavioral risk, wherein the genetic risk is determined by detecting in a sample obtained from a subject the presence or absence of a single nucleotide polymorphism SNP listed in Tables 3, 4, 5, 6, 7, 8, 9, or 10, or proxy therefor, wherein the presence of the allele is indicative of an increased risk of the subject developing AMD or a severe form of AMD. In various embodiments, behavioral risk is assessed by determining if the subject exhibits a behavior or trait selected from: obesity, smoking, vitamin and dietary supplement intake, use of alcohol or drugs, poor diet, a sedentary lifestyle, medical history of heart disease or other vascular disease, and medical history of kidney or liver disease. 
     
    
     
       BRIEF DESCRIPTION OF DRAWINGS 
         [0017]    The figures are not necessarily to scale, emphasis instead generally being placed upon illustrative principles. The figures are to be considered illustrative in all aspects and are not intended to limit the invention, the scope of which is defined only by the claims. 
           [0018]      FIGS. 1 and 2  are nucleic acid sequences of VEGFA and GDF6 SNPs, respectively, in accordance with an illustrative embodiment. 
           [0019]      FIGS. 3A and 3B  are graphs showing a preliminary χ2 association analysis, in accordance with an illustrative embodiment. 
           [0020]      FIG. 4  is a graph showing 80% power to detect a biallelic CNV, in accordance with an illustrative embodiment. 
           [0021]      FIGS. 5.1  and  5 . 2  are nucleic acid sequences of various SNPs, in accordance with an illustrative embodiment. 
           [0022]      FIGS. 6   a - d  show the FRI/COL10A1 region and VEGFA region, and association with AMD, in accordance with an illustrative embodiment. 
           [0023]      FIG. 7  shows distribution of genetic ancestry estimated by EIGENSOFT, in accordance with an illustrative embodiment. 
           [0024]      FIG. 8  shows quantile-quantile (Q;Q) plots, in accordance with an illustrative embodiment. 
           [0025]      FIG. 9  shows a Manhattan-Plot, in accordance with an illustrative embodiment. 
       
    
    
     DETAILED DESCRIPTION 
       [0026]    The present invention relates, in part, to the discovery that particular alleles at polymorphic sites associated with genes, including alpha chain of type X collagen (COL10A1), vascular endothelial growth factor A (VEGFA) and growth/differentiation factor 6 (GDF6) are useful as markers for AMD etiology, for determining susceptibility to AMD, and for predicting or monitoring disease progression or severity, e.g., to determine a treatment course and/or to titrate dosages of therapeutic agents. More specifically, and by non-limiting example, the single nucleotide polymorphisms (SNPs) rs4711751 in the VEGFA gene and rs6982567 in the GDF6 gene can be used as markers for AMD etiology, for determining susceptibility to AMD, and for predicting disease progression or severity, and for distinguishing risk of geographic atrophy, the advanced dry type of AMD from the advanced wet form of AMD. In addition, Tables 3, 4, 5, 6, 7, 8, 9, and 10 list additional polymorphisms that are also useful as such markers. Furthermore, genes and/or markers in linkage disequilibrium with these SNPs provide additional such markers. 
         [0027]    As used herein, “gene” is a term used to describe a genetic element that gives rise to expression products (e.g., pre-mRNA, mRNA and polypeptides). A gene can include regulatory elements, exons and sequences that otherwise appear to have only structural features, e.g., introns and untranslated regions. 
         [0028]    The genetic markers disclosed herein are particular “alleles” at “polymorphic sites” associated with various genes, including VEGFA, GFD6, and any markers identified in tables 3-10. A nucleotide position at which more than one nucleotide can be present in a population (either a natural population or a synthetic population, e.g., a library of synthetic molecules), is referred to herein as a “polymorphic site”. Where a polymorphic site is a single nucleotide in length, the site is referred to as a single nucleotide polymorphism (“SNP”). If at a particular chromosomal location, for example, one member of a population has an adenine and another member of the population has a thymine at the same genomic position, then this position is a polymorphic site, and, more specifically, the polymorphic site is a SNP. Polymorphic sites can allow for differences in sequences based on substitutions, insertions or deletions. Each version of the sequence with respect to the polymorphic site is referred to herein as an “allele” of the polymorphic site. Thus, in the previous example, the SNP allows for both an adenine allele and a thymine allele. 
         [0029]    A genetic marker is “associated” with a genetic element or phenotypic trait, for example, if the marker is co-present with the genetic element or phenotypic trait at a frequency that is higher than would be predicted by random assortment of alleles (based on the allele frequencies of the particular population). Association also indicates physical association, e.g., proximity in the genome or presence in a haplotype block, of a marker and a genetic element. 
         [0030]    A reference sequence is typically referred to for a particular genetic element, e.g., a gene. The reference sequence, often chosen as the most frequently occurring allele, is referred to as a “wild type” allele or the “major allele”). Alleles that are more common or less common in individuals with a disease/trait compared to individuals without the disease/trait, with a certain level of statistical significance, are referred to as the variant alleles. The corresponding genotype is referred to as a genetic variant. 
         [0031]    Some variant alleles can include changes that affect a polypeptide or protein, e.g., the polypeptide encoded by a variant allele. These sequence differences, when compared to a reference nucleotide sequence, can include, for example, the insertion or deletion of a single nucleotide, or of more than one nucleotide, resulting in a frame shift; the change of at least one nucleotide, resulting in a change in the encoded amino acid; the change of at least one nucleotide, resulting in the generation of a premature stop codon; the deletion of several nucleotides, resulting in a deletion of one or more amino acids encoded by the nucleotides; the insertion of one or several nucleotides, such as by unequal recombination or gene conversion, resulting in an interruption of the coding sequence of a reading frame; duplication of all or a part of a sequence; transposition; or a rearrangement of a nucleotide sequence. 
         [0032]    Alternatively, a polymorphism associated with AMD or a susceptibility to AMD can be a synonymous change in one or more nucleotides (i.e., a change that does not result in a change to a codon of a complement pathway gene). Such a polymorphism can, for example, alter splice sites, affect the stability or transport of mRNA, or otherwise affect the transcription or translation of the polypeptide. The polypeptide encoded by the reference nucleotide sequence is the “reference” polypeptide with a particular reference amino acid sequence, and polypeptides encoded by variant alleles are referred to as “variant” polypeptides with variant amino acid sequences. 
         [0033]    A haplotype is a combination or set of genetic markers, e.g., particular alleles at polymorphic sites, such as, e.g., SNPs and/or microsatellites. The haplotypes described herein are associated with AMD and/or a susceptibility to AMD. Detection of the presence or absence of the haplotypes herein, therefore, is indicative of AMD, is indicative of a susceptibility to AMD, is indicative of a factor related to progression from early to intermediate or late stages of AMD, is indicative of progression from intermediate to late stages of AMD, or is indicative of a lack of AMD. Detecting haplotypes, therefore, can be accomplished by methods known in the art for detecting sequences at polymorphic sites. 
         [0034]    “Linkage” refers to a higher than expected statistical association of genotypes and/or phenotypes with each other. Linkage disequilibrium (“LD”) refers to a non-random assortment of two genetic elements. If a particular genetic element (e.g., an allele at a polymorphic site), for example, occurs in a population at a frequency of 0.25 and another occurs at a frequency of 0.25, then the predicted occurrence of a person&#39;s having both elements is 0.125, assuming a random distribution of the elements. If, however, it is discovered that the two elements occur together at a frequency higher than 0.125, then the elements are said to be in LD since they tend to be inherited together at a higher frequency than what their independent allele frequencies would predict. Roughly speaking, LD is generally correlated with the frequency of recombination events between the two elements. Allele frequencies can be determined in a population, for example, by genotyping individuals in a population and determining the occurrence of each allele in the population. For populations of diploid individuals, e.g., human populations, individuals will typically have two alleles for each genetic element (e.g., a marker or gene). 
         [0035]    The invention is also directed to markers identified in a “haplotype block” or “LD block”. These blocks are defined either by their physical proximity to a genetic element, e.g., a VEGFA, GDF6, or the other markers provided herein, or by their “genetic distance” from the element. Markers and haplotypes identified in these blocks, because of their association with AMD and VEGFA, GDF6, or the markers identified herein, are encompassed by the invention. One of sk111 in the art will appreciate regions of chromosomes that recombine infrequently and regions of chromosomes that are “hotspots”, e.g., exhibiting frequent recombination events, are descriptive of LD blocks. Regions of infrequent recombination events bounded by hotspots will form a block that will be maintained during cell division. Thus, identification of a marker associated with a phenotype, wherein the marker is contained within an LD block, identifies the block as associated with the phenotype. Any marker identified within the block can therefore be used to indicate the phenotype. 
         [0036]    Additional markers that are in LD with the markers of the invention or haplotypes are referred to herein as “surrogate” markers (i.e., “proxy” markers). Such a surrogate is a marker for another marker or another surrogate marker. Surrogate markers are themselves markers and are indicative of the presence of another marker, which is in turn indicative of either another marker or an associated phenotype. 
         [0037]    Susceptibility for developing AMD includes an asymptomatic patient showing increased risk to develop AMD, and a patient having early or intermediate stages of AMD indicating a progression toward more advanced forms of AMD and expected visual loss. Susceptibility for not developing AMD includes an asymptomatic patient having at least one wild type allele, or a non-risk genotype, or a protective genotype, or a non-risk allele, or a protective allele, or a non-risk haplotype, or a protective haplotype indicates a lack of a predisposition for developing AMD. 
         [0038]    Genetic markers (e.g., SNPs) can be detected in nucleic acids (e.g., DNA or mRNA) in any suitable sample source obtained or taken from an individual, including blood, saliva, feces, bone, epithelial cells, endothelial cells, blood cells, and other bodily fluids, cells, and/or tissues. 
         [0039]    Table 10 lists representative markers which are associated with AMD. These markers, or markers in linkage disequilibrium with these markers (e.g., R squared=0.2 or higher), can be used as markers for AMD etiology, for determining susceptibility to AMD, and for predicting disease progression or severity, and for distinguishing risk of geographic atrophy, the advanced dry type of AMD from the advanced wet form of AMD. 
         [0000]    
       
         
               
             
               
               
               
               
               
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 10 
               
             
             
               
                   
               
               
                 Markers of AMD 
               
             
          
           
               
                 SNP 
                 GENE 
                 CHR 
                 BP(hg19) 
                 BP(hg18) 
                 BEST-P 
               
               
                   
               
             
          
           
               
                 rs4711751 
                 VEGF 
                 6 
                 43828582 
                 43936560 
                 8.7E−09 
               
               
                 rs1999930 
                 COL10A1/FRK 
                 6 
                 116387134 
                 116493827 
                 1.1E−08 
               
               
                 rs13278062 
                 TNFRSF10A 
                 8 
                 23082971 
                 23138916 
                 3.8E−06 
               
               
                 rs1912795 
                 B3GALTL 
                 13 
                 31838688 
                 30736688 
                 3.2E−05 
               
               
                 rs2270637 
                 SLC18A1 
                 8 
                 20036827 
                 20081107 
                 3.8E−06 
               
               
                 rs6982567 
                 GDF6 
                 8 
                 96750281 
                 96819457 
                 6.1E−06 
               
               
                 rs12040406 
                 CD55 
                 1 
                 207449304 
                 205515927 
                 2.8E−07 
               
               
                 rs1367068 
                   
                 1 
                 207394941 
                 205461564 
                 2.1E−07 
               
               
                 rs1079982 
                 CARD10 
                 22 
                 37929759 
                 36259705 
                 3.0E−06 
               
               
                 rs1443179 
                 INTU 
                 4 
                 128276322 
                 128495772 
                 1.4E−06 
               
               
                 rs7720497 
                 ADAMTS16 
                 5 
                 5238813 
                 5291813 
                 3.5E−06 
               
               
                 rs61800454 
                 TMCO1 
                 1 
                 165720343 
                 163986967 
                 5.4E−05 
               
               
                   
               
             
          
         
       
     
       Diagnostic Gene Array 
       [0040]    In one aspect, the invention comprises an array of gene fragments, particularly nucleic acids including one or more SNPs given as SEQ ID NOS:1-15 and/or sequences including the SNPs identified in Tables 3, 4, 5, 6, 7, 8, 9, or 10 and probes for detecting the allele at the SNPs of one or more of SEQ ID NOS:1-15 and/or sequences including the SNPs identified in Tables 3, 4, 5, 6, 7, 8, 9, and 10. Polynucleotide arrays provide a high throughput technique that can assay a large number of polynucleotide sequences in a single sample. This technology can be used, for example, as a diagnostic tool to assess the risk potential of developing AMD using the SNPs and probes of the invention. Polynucleotide arrays (for example, DNA or RNA arrays), include regions of usually different sequence polynucleotides arranged in a predetermined configuration on a substrate, at defined x and y coordinates. These regions (sometimes referenced as “features”) are positioned at respective locations (“addresses”) on the substrate. The arrays, when exposed to a sample, will exhibit an observed binding pattern. This binding pattern can be detected upon interrogating the array. For example, all polynucleotide targets (for example, DNA) in the sample can be labeled with a suitable label (such as a fluorescent compound), and the fluorescence pattern on the array accurately observed following exposure to the sample. Assuming that the different sequence polynucleotides were correctly deposited in accordance with the predetermined configuration, then the observed binding pattern will be indicative of the presence and/or concentration of one or more polynucleotide components of the sample. 
         [0041]    Arrays can be fabricated by depositing previously obtained biopolymers onto a substrate, or by in situ synthesis methods. The substrate can be any supporting material to which polynucleotide probes can be attached, including but not limited to glass, nitrocellulose, silicon, and nylon. Polynucleotides can be bound to the substrate by either covalent bonds or by non-specific interactions, such as hydrophobic interactions. The in situ fabrication methods include those described in U.S. Pat. No. 5,449,754 for synthesizing peptide arrays, and in U.S. Pat. No. 6,180,351 and WO 98/41531 and the references cited therein for synthesizing polynucleotide arrays. Further details of fabricating biopolymer arrays are described in U.S. Pat. No. 6,242,266; U.S. Pat. No. 6,232,072; U.S. Pat. No. 6,180,351; U.S. Pat. No. 6,171,797; EP No. 0 799 897; PCT No. WO 97/29212; PCT No. WO 97/27317; EP No. 0 785 280; PCT No. WO 97/02357; U.S. Pat. Nos. 5,593,839; 5,578,832; EP No. 0 728 520; U.S. Pat. No. 5,599,695; EP No. 0 721 016; U.S. Pat. No. 5,556,752; PCT No. WO 95/22058; and U.S. Pat. No. 5,631,734. Other techniques for fabricating biopolymer arrays include known light directed synthesis techniques. Commercially available polynucleotide arrays, such as Affymetrix GeneChip™, can also be used. Use of the GeneChip™, to detect gene expression is described, for example, in Lockhart et al.,  Nat. Biotechnol.,  14:1675, 1996; Chee et al.,  Science,  274:610, 1996; Hacia et al.,  Nat. Gen.,  14:441, 1996; and Kozal et al.,  Nat. Med.,  2:753, 1996. Other types of arrays are known in the art, and are sufficient for developing an AMD diagnostic array of the present invention. 
         [0042]    To create the arrays, single-stranded polynucleotide probes can be spotted onto a substrate in a two-dimensional matrix or array. Each single-stranded polynucleotide probe can comprise at least 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 25, or 30 or more contiguous nucleotides selected from the nucleotide sequences shown in SEQ ID NO:1-15 and/or sequences including the SNPs identified in Tables 3, 4, 5, 6, 7, 8, 9, and 10, or the complement thereof. Preferred arrays comprise at least one single-stranded polynucleotide probe comprising at least 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 25, or 30 or more contiguous nucleotides selected from the nucleotide sequences shown in SEQ ID NO:1-15, and/or sequences including the SNPs identified in Tables 3, 4, 5, 6, 7, 8, 9, and 10, or the complement thereof. 
         [0043]    Tissue samples from a subject can be treated to form single-stranded polynucleotides, for example by heating or by chemical denaturation, as is known in the art. The single-stranded polynucleotides in the tissue sample can then be labeled and hybridized to the polynucleotide probes on the array. Detectable labels that can be used include but are not limited to radiolabels, biotinylated labels, fluorophors, and chemiluminescent labels. Double stranded polynucleotides, comprising the labeled sample polynucleotides bound to polynucleotide probes, can be detected once the unbound portion of the sample is washed away. Detection can be visual or with computer assistance. Preferably, after the array has been exposed to a sample, the array is read with a reading apparatus (such as an array “scanner”) that detects the signals (such as a fluorescence pattern) from the array features. Such a reader preferably would have a very fine resolution (for example, in the range of five to twenty microns) for an array having closely spaced features. 
         [0044]    The signal image resulting from reading the array can then be digitally processed to evaluate which regions (pixels) of read data belong to a given feature as well as to calculate the total signal strength associated with each of the features. The foregoing steps, separately or collectively, are referred to as “feature extraction” (U.S. Pat. No. 7,206,438). Using any of the feature extraction techniques so described, detection of hybridization of a patient derived polynucleotide sample with one of the AMD markers on the array given as SEQ ID NO:1-15 and/or sequences including the SNPs identified in Tables 3, 4, 5, 6, 7, 8, 9, and 10 identifies that subject as having or not having a genetic risk factor for AMD, as described above. 
       System for Analyzing Patient Data 
       [0045]    In another aspect, the invention provides a system for compiling and processing patient data, and presenting a risk profile for developing AMD or for the progression to late stages. A computer aided medical data exchange system is preferred. The system is designed to provide high-quality medical care to a patient by facilitating the management of data available to care providers. The care providers will typically include physicians, surgeons, nurses, clinicians, various specialists, and so forth. It should be noted, however, that while general reference is made to a clinician in the present context, the care providers may also include clerical staff, insurance companies, teachers and students, and so forth. The system provides an interface, which allows the clinicians to exchange data with a data processing system. The data processing system is linked to an integrated knowledge base and a database. 
         [0046]    The database may be software-based, and includes data access tools for drawing information from the various resources as described below, or coordinating or translating the access of such information. In general, the database will unify raw data into a useable form. Any suitable form may be employed, and multiple forms may be employed, where desired, including hypertext markup language (HTML) extended markup language (XML), Digital Imaging and Communications in Medicine (DICOM), Health Level Seven™ (HL7), and so forth. In the present context, the integrated knowledge base is considered to include any and all types of available medical data that can be processed by the data processing system and made available to the clinicians for providing the desired medical care. In general, data within the resources and knowledge base are digitized and stored to make the data available for extraction and analysis by the database and the data processing system. Even where more conventional data gathering resources are employed, the data is placed in a form that permits it to be identified and manipulated in the various types of analyses performed by the data processing system. 
         [0047]    The integrated knowledge base is intended to include one or more repositories of medical-related data in a broad sense, as well as interfaces and translators between the repositories, and processing capabilities for carrying out desired operations on the data, including analysis, diagnosis, reporting, display and other functions. The data itself may relate to patient-specific characteristics as well as to non-patient specific information, as for classes of persons, machines, systems and so forth. Moreover, the repositories may include devoted systems for storing the data, or memory devices that are part of disparate systems, such as imaging systems. As noted above, the repositories and processing resources making up the integrated knowledge base may be expandable and may be physically resident at any number of locations, typically linked by dedicated or open network links. Furthermore, the data contained in the integrated knowledge base may include both clinical data (e.g., data relating specifically to a patient condition) and non-clinical data. Examples of preferred clinical data include patient medical histories, patient serum, plasma, and/or other biomarkers such as blood levels of certain other nutrients, fats, female and male hormones, etc., and cellular antioxidant levels, and the identification of past or current environmental, lifestyle and other factors that predispose a patient to develop AMD. These include but are not limited to various risk factors such as obesity, smoking, vitamin and dietary supplement intake, use of alcohol or drugs, poor diet, a sedentary lifestyle, medical history of heart disease or other vascular disease, and/or medical history of kidney or liver disease. Non-clinical data may include more general information about the patient, such as residential address, data relating to an insurance carrier, and names and addresses or phone numbers of significant or recent practitioners who have seen or cared for the patient, including primary care physicians, specialists, and so forth. 
         [0048]    The flow of information can include a wide range of types and vehicles for information exchange. In general, the patient can interface with clinicians through conventional clinical visits, as well as remotely by telephone, electronic mail, forms, and so forth. The patient can also interact with elements of the resources via a range of patient data acquisition interfaces that can include conventional patient history forms, interfaces for imaging systems, systems for collecting and analyzing tissue samples, body fluids, and so forth. Interaction between the clinicians and the interface can take any suitable form, depending upon the nature of the interface. Thus, the clinicians can interact with the data processing system through conventional input devices such as keyboards, computer mice, touch screens, portable or remote input and reporting devices. The links between the interface, data processing system, the knowledge base, the database and the resources typically include computer data exchange interconnections, network connections, local area networks, wide area networks, dedicated networks, virtual private network, and so forth. 
         [0049]    In general, the resources can be patient-specific or patient-related, that is, collected from direct access either physically or remotely (e.g., via computer link) from a patient. The resource data can also be population-specific so as to permit analysis of specific patient risks and conditions based upon comparisons to known population characteristics. It should be noted that the resources can generally be thought of as processes for generating data. While many of the systems and resources will themselves contain data, these resources are controllable and can be prescribed to the extent that they can be used to generate data as needed for appropriate treatment of the patient. Exemplary controllable and prescribable resources include, for example, a variety of data collection systems designed to detect physiological parameters of patients based upon sensed signals. Such electrical resources can include, for example, electroencephalography resources (EEG), electrocardiography resources (ECG), electromyography resources (EMG), electrical impedance tomography resources (EIT), nerve conduction test resources, electronystagmography resources (ENG), and combinations of such resources. Various imaging resources also can be controlled and prescribed as necessary. Exemplary eye tests include, for example, electrophysiologic tests, elcetroretinograms, electrooculagrams, retinal angiography, retinal photography, ultrasonography, optical coherence tomography, and other imaging modalities such as autofluorescence. A number of modalities of such resources are currently available, such as, for example, X-ray imaging systems, magnetic resonance (MR) imaging systems, computed tomography (CT) imaging systems, positron emission tomography (PET) systems, fluorography systems, sonography systems, infrared imaging systems, nuclear imaging systems, thermoacoustic systems, and so forth. Imaging systems can draw information from other imaging systems, electrical resources can interface with imaging systems for direct exchange of information (such as for timing or coordination of image data generation, and so forth). 
         [0050]    In addition to such electrical and highly automated systems, various resources of a clinical and laboratory nature can be accessible. Such resources may include blood, urine, saliva and other fluid analysis resources, including gastrointestinal, reproductive, urological, nephrological (kidney function), and cerebrospinal fluid analysis system. Such resources can further include polymerase (PCR) chain reaction analysis systems, genetic marker analysis systems, radioimmunoassay systems, chromatography and similar chemical analysis systems, receptor assay systems and combinations of such systems. Histologic resources, somewhat similarly, can be included, such as tissue analysis systems, cytology and tissue typing systems and so forth. Other histologic resources can include immunocytochemistry and histopathological analysis systems. Similarly, electron and other microscopy systems, in situ hybridization systems, and so forth can constitute the exemplary histologic resources. Pharmacokinetic resources can include such systems as therapeutic drug monitoring systems, receptor characterization and measurement systems, and so forth. Again, while such data exchange can be thought of passing through the data processing system, direct exchange between the various resources can also be implemented. 
         [0051]    Use of the present system involves a clinician obtaining a patient sample, and evaluation of the presence of a genetic marker in that patient indicating a predisposition (or not) for AMD or its progression, such as one or more of SEQ ID NO:1-15, and/or sequences including the SNPs identified in Tables 3, 4, 5, 6, 7, 8, 9, and 10 alone or in combination with other known risk factors. The clinician or their assistant also obtains appropriate clinical and non-clinical patient information, and inputs it into the system. The system then compiles and processes the data, and provides output information that includes a risk profile for the patient, of developing AMD and/or progressing to advanced forms of AMD. 
         [0052]    The present invention thus provides for certain polynucleotide sequences that have been correlated to AMD. These polynucleotides are useful as diagnostics, and are preferably used to fabricate an array, useful for screening patient samples. The array, in a currently most preferred embodiment, is used as part of a laboratory information management system, to store and process additional patient information in addition to the patient&#39;s genomic profile. As described herein, the system provides an assessment of the patient&#39;s risk for developing AMD, risk for disease progression, and likelihood of disease prevention based on patient controllable factors. 
       Kits 
       [0053]    The invention relates in part to kits and systems useful for performing the diagnostic methods described herein. The methods described herein can be performed by, for example, diagnostic laboratories, service providers, experimental laboratories, and individuals. The kits can be useful in these settings, among others. 
         [0054]    Kits include reagents and materials for obtaining genetic material and assaying one or more markers in a sample from an individual, analyzing the results, diagnosing whether the individual is susceptible to or at risk for developing AMD, monitoring disease progression, and/or determining an appropriate treatment course. For example, in some embodiments, the kit can include a needle, syringe, vial, cotton swap or other apparatus for obtaining and/or containing a sample from an individual. In some embodiments, the kit can include at least one reagent which is used specifically to detect a marker disclosed herein. That is, suitable reagents and techniques readily can be selected by one of skill in the art for inclusion in a kit for detecting or quantifying a marker of interest. 
         [0055]    For example, where the marker is a nucleic acid (e.g., DNA or RNA), the kit includes reagents appropriate for detecting nucleic acids using, for example, PCR, hybridization techniques, and microarrays. 
         [0056]    Where appropriate, the kit includes: extraction buffers or reagents, amplification buffers or reagents, reaction buffers or reagents, hybridization buffers or reagents, immunodetection buffers or reagents, labeling buffers or reagents, and detection means. The kit can include all or part of the nucleic acids of SEQ ID NOS:1-15 and/or a nucleic acid including a SNP identified in Tables 3, 4, 5, 6, 7, 8, 9, and 10, or a nucleic acid molecule complementary thereto. 
         [0057]    Kits can also include a control, which can be a control sample, a reference sample, an internal standard, or previously generated empirical data. The control may correspond to a known allele, e.g., a wild type and/or a variant allele. In addition, a control may be provided for each marker or the control may be a reference (e.g., a wild type and/or variant sequence). 
         [0058]    Kits can include one or more containers for each individual reagent. Kits can further include instructions for performing the methods described herein and/or interpreting the results, in accordance with any regulatory requirements. In addition, software can be included in the kit for analyzing the results. Preferably, the kits are packaged in a container suitable for commercial distribution, sale, and/or use. 
         [0059]    The following examples are provided for illustration, not limitation. 
       Example 1 
     Discovery of Genetic Variants Associated with AMD 
       [0060]    Age-related macular degeneration (AMD), the leading cause of late onset blindness, arises from retinal damage associated with accumulation of drusen and subsequent atrophy or neovascularization that leads to loss of central vision. The results of a genome-wide association study (GWAS) of 979 advanced AMD cases and 1709 controls using the Affymetrix 6.0 platform with replication in seven additional cohorts (totaling 4337 unrelated cases and unrelated 2077 controls) are presented. These data were combined with the data from the Michigan/Penn/Mayo (MPM) GWAS, which was obtained from a public database, to increase sample size. The Michigan/Penn/Mayo (MPM) GWAS implicated different genes. Analyses of the raw genetic data implicated associated variants in the reference single nucleotide polymorphisms listed in Tables 3, 4, and 5, including the VEGFA gene (discovery P=2.66e-05) and the GDF6 gene (discovery P=6.14e-06). In Tables 3 and 5, for example, the effective allele (EA) and odds ratio (OR) are given for each polymorphism. For example, if T is the effective allele and the OR is 1.2, then the T allele is associated with a 20% higher risk compared to the other allele. If C is the effective allele, and the OR is 0.80, then the C allele is associated with a 20% lower risk compared to the other allele. 
         [0061]    In Tables 3-10, the column headers include: SNP, single nucleotide polymorphism; GENE, gene of interest within or near putative interval; Chr, chromosome; BP or POS, base-pair position; EA, effective allele; OR, odds ratio; A1, minor allele; A2, major allele; Meta_P, P value for the association between the minor allele and AMD; Z, weighted average and direction of minor allele signal; and P, P value. 
         [0062]    Age-related macular degeneration (AMD) is a common, late-onset disorder that is modified by covariates including smoking and BMI, and has a 3-6 fold higher recurrence ratio in siblings than in the general population. The burden of AMD is clinically significant, causes visual loss, and reduces quality of life. Among individuals age 75 or older, approximately one in four have some sign of this disease, while about one in 15 have the advanced form with visual loss. 
         [0063]    Described herein is a study involving 979 cases of advanced AMD in the discovery phase with multiple stages of replication. Samples (e.g., blood samples) were genotyped on the Affymetrix 6.0, platform which contains probes for 906,000 SNPs and an additional 946,000 SNP-invariant probes to enhance copy number variation (CNV) analysis and captures 82% of the variation at an r 2 &gt;0.8 for Europeans in the 3.1 million SNPs of HapMap phase 2. These data were combined with data with raw genetic data from a public database and conducted imputation using the HapMap phase 3 and the raw genetic data from the publicly available 1000 genomes project. Analyses of the resultant dataset uncovered several new AMD susceptibility loci for AMD. Significant, replicated associations include variations in VEGFA and GFD6, thus revealing novel markers associated with AMD pathogenesis. Additional associated markers include the SNPs listed in Tables 3, 4, 5, 6, 7, 8, 9, and 10. 
       Methods 
       [0064]    Briefly, a genome-wide association (GWAS) was combined with the MPM results as described more detail below. SNPs were imputed based on the HapMap 3 SNP database, and also imputed results based on pilot data from another public database called “the 1000 Genomes project”. Using this dataset as the discovery sample, VEGFA SNP rs4711751 was found to be in linkage disequilibrium with AMD, with a p value of p=2.66e-05. Another marker, GDF6 SNP rs6982567 also was found to be in linkage disequilibrium with AMD, with a p value of p=6.14e-6. These data were sent to other groups for replication using TaqMan® or Sequenom® assays, and the association was confirmed. Additional markers which are candidates for genetic variants associated with AMD are listed in Tables 3, 4, and 5. 
       Study Sample Descriptions 
       [0065]    The methods employed in this study conformed to the tenets of the Declaration of Helsinki, received approval from Institutional Review Boards, and informed consent was signed by all participants. Some methods have been described in detail previously. (Neale, et al., “Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).” Proc Natl Acad Sci USA 107, 7395-400 (2010); Fagerness, et al., “Variation near complement factor I is associated with risk of advanced AMD.” Eur J Hum Genet 17, 100-4 (2009); Maller, et al., “Variation in complement factor 3 is associated with risk of age-related macular degeneration.” Nat Genet 39, 1200-1 (2007); Maller, et al., “Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration.” Nat Genet 38, 1055-9 (2006)) Cases had geographic atrophy or neovascular disease based on fundus photography and ocular examination (Clinical Age-Related Maculopathy Grading System (CARMS) stages 4 and 5). (Seddon, et al., “Evaluation of the clinical age-related maculopathy staging system.” Ophthalmology 113, 260-6 (2006)) 
         [0066]    Controls were unrelated to cases, 60 years of age or older, and were defined as individuals without macular degeneration, categorized as CARMS stage 1, based on fundus photography and ocular examination. Subjects were derived from ongoing AMD study protocols as described previously. 
         [0067]    Tufts/MGH Subjects included in the current GWAS were derived from ongoing AMD study protocols as described previously. (Neale, et al., “Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).” Proc Natl Acad Sci USA 107, 7395-400 (2010); Maller, et al., “Common variation in three genes, including a noncoding variant in CFH, strongly influences risk of age-related macular degeneration.” Nat Genet 38, 1055-9 (2006); Seddon, et al., “Progression of age-related macular degeneration: association with body mass index, waist circumference, and waist-hip ratio.” Arch Ophthalmol 121, 785-92 (2003); Seddon, et al., “A genomewide scan for age-related macular degeneration provides evidence for linkage to several chromosomal regions.” Am J Hum Genet 73, 780-90 (2003); Seddon, et al., “The US twin study of age-related macular degeneration: relative roles of genetic and environmental influences.” Arch Ophthalmol 123, 321-7 (2005); “A randomized, placebo-controlled, clinical trial of high-dose supplementation with vitamins C and E, beta carotene, and zinc for age-related macular degeneration and vision loss: AREDS report no. 8.” Arch Ophthalmol 119, 1417-36 (2001)) MMAP Subjects included in the current GWAS were obtained from dbGaP (http://dbgap.ncbi.nlm.nih.gov/aa/wga.cgi?page=DUC&amp;view_pdf&amp;stacc=phs000182.v2.p1) and described previously. (Chen, W., et al., “Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.” Proc Natl Acad Sci USA 107, 7401-6 (2010)) Shared controls from GAIN Schizophrenia Study were obtained from dbGap (http://dbgap.ncbi.nlm.nih.gov/aa/wga.cgi?page=DUC&amp;view_pdf&amp;stacc=phs00002 1.v2.p1) and described (Manolio, T. A., et al., “New models of collaboration in genome-wide association studies: the Genetic Association Information Network.” Nat Genet 39, 1045-51 (2007)) The datasets of Tufts/MGH replication, MIGEN controls, Johns Hopkins University (JHU), Columbia University (COL), Washington University (Wash-U), and Hopital Intercommunal de Creteil (FR-CRET) were included in a previous study. (Neale, et al., “Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (UPC).” Proc Natl Acad Sci USA 107, 7395-400 (2010) The datasets Centre for Eye Research Australia (AUS), Genentech, Decode (Iceland) and Rotterdam (ROT) applied the same criteria for the diagnosis and IRB approved protocols of their samples. 
       Genotyping Using Genome-Wide Panels 
       [0068]    The GWAS genotyping of Tufts/MGH samples and MIGEN samples were performed at the Broad and National Center for Research Resources (NCRR) Center for Genotyping and Analysis using the Affymetrix SNP 6.0 GeneChip (909622 SNPs). (Korn, et al., “Integrated genotype calling and association analysis of SNPs, common copy number polymorphisms and rare CNVs.” Nat Genet 40, 1253-60 (2008)) Shared controls froth GAIN study were also genotyped by using the Affymetrix SNP 6.0 GeneChip. MMAP samples were genotyped by Illumina HumanCNV370v1 Bead Array (ILMN 370, 370404 SNPs). (Chen, W., et al., “Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.” Proc Natl Acad Sci USA 107, 7401-6 (2010)) 
       Other Replication Genotyping 
       [0069]    Samples from Hopital Intercommunal de Creteil (FR-CRET) and Tufts-replication were genotyped at the Broad Institute Center by the Sequenom iPLEX assay (http://www.sequenom.com/Genetic-Analysis/Applications/iPLEX-Genotyping/iPLEX-Overview.aspx). Samples from Wash-U and AUS were genotyped by the Sequenom iPLEX assay at each respective site. Samples from JHU and COL were genotyped by the TaqMan assay using the ABI PRISM 7900 Sequence Detection System (ABI, Foster City, Calif., USA) (https://products.appliedbiosystems.com/ab/en/US/adirect/ab?cmd=catNavigate2&amp;c atID=601283). 
       Quality Control 
       [0070]    Quality control procedures for the genotype data of Tufts/MGH and MMAP have been described in detail. (Neale, et al., “Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).” Proc Natl Acad Sci USA 107, 7395-400 (2010); Chen, W., et al., “Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.” Proc Natl Acad Sci USA 107, 7401-6 (2010)). Briefly, individuals with call rates&lt;0.95 then SNPs with call rates&lt;0.98, Hardy-Weinberg equilibrium P&lt;10 −6 , and MAF&lt;0.01 were excluded. Potential relatedness between individuals was identified through a Genome-wide identity-by-state (IBS) matrix using PLINK. (Purcell, et al., “PLINK: a tool set for whole-genome association and population-based linkage analyses.” Am J Hum Genet 81, 559-75 (2007)) IBS was estimated for each pair of individuals and one individual from each duplicate or related pair (pihat&gt;0.2) was removed. Ancestry outliers were identified based on principle components analysis (PCA) using EIGENSOFT ( FIG. 7 ). (Price, et al., “Principal components analysis corrects for stratification in genome-wide association studies.” Nat Genet 38, 904-9 (2006).) 
       Imputation and Statistical Analysis 
       [0071]    Stringent quality control checks described in Table 13 were applied on each of the data sets contribute to TMMG samples. We next used BEAGLE version 3.0 (Browning, et al., “A unified approach to genotype imputation and haplotype-phase inference for large data sets of trios and unrelated individuals.” Am J Hum Genet 84, 210-23 (2009); Browning, et al., “Rapid and accurate haplotype phasing and missing-data inference for whole-genome association studies by use of localized haplotype clustering.” Am J Hum Genet 81, 1084-97 (2007)) to infer genotypes using the phased CEU and TSI samples (566 haplotypes) of the 1000 Genomes project as a reference. The imputations were performed separately for those cases and controls genotyped on platforms with AFFY 6.0 (more SNPs) and those genotyped with ILMN 370 (less SNPs). For inclusion of data we utilized only imputed genotypes with imputation quality scores&gt;0.6 where the score is defined as the ratio-of-variances (empirical/asymptotic) of each genotype. This score is equivalent to the RSQR_HAT value by MACH and the information content (INFO) measure by PLINK. Since the imputation accuracy are relative low for SNPs with low minor allele frequency (MAF), we only included imputed genotypes of common variants (MAF&gt;0.01) in the analysis. PLINK was used as the primary association test for the imputed genotypes coded by the genotype probabilities for each SNP. The eigenvalue scores with nominal siginificant (p&lt;0.05) association to case/control status (first seven PCAs, PCA 11 and PCA 16) and the original genotyping platform were adjusted as covariates in the association test. The P-value for the combined analysis was derived from the sum of weighted average Z score by the Stouffer&#39;s Z-score method as previously described. Neale, et al., “Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC).” Proc Natl Acad Sci USA 107, 7395-400 (2010) The Z score was weighted by the effective sample size of each independent replication cohort if the ratio between cases and controls was equal to 1 based on actual samples listed in Table 12. Heterogeneity of the association between SNP and disease was evaluated by the Cochran&#39;s Q-test. 
         [0072]      FIG. 7  shows distribution of genetic ancestry along PC1 and PC2 estimated by EIGENSOFT, colored by case (red)/control (blue) status and displayed by the original genotyping platforms, AFFY 6.0 (circle)/ILMN 370 (cross) in all TMMG samples before (left plot) and after (right plot) excluding outliers (PC2&gt;0.05). 
         [0073]      FIG. 8  shows quantile-quantile (Q;Q) plots. We plotted our genome-wide association findings from the cleaned TMMG dataset in Quantile-Quantile (Q:Q) plots. The Q:Q plot on the left represents the strong associations of the CFH, ARMS2/HTRA1, C2/CFB, C3, CFI and LIPC regions that has been previously associated. The Q:Q plot on the right represents the association results of SNPs after excluding these previous associated regions. 
         [0074]      FIG. 9  shows a Manhattan-Plot. The log(p-values) of association results from the cleaned TMMG dataset were plotted for SNPs on each chromosome. SNPs with P&lt;5×10 −7  were colored in red and the representative genes for each associated region were labeled. 
         [0075]    We genotyped 1242 cases and 492 controls of European ancestry, diagnosed based on fundus photography and ocular examination, 1188 controls from the Myocardial Infarction Genetics Consortium (MIGen), 1378 controls from the GAIN Schizophrenia Study and 1355 cases/1076 controls from the Michigan, Mayo, AREDS, Pennsylvania (MMAP) Cohort Study. After thorough quality control analyses, the merged dataset of Tufts/MMAP/MIGen/GAIN (TMMG) contained 6728 samples, of which 4300 were genotyped by Affymetrix SNP 6.0 GeneChip and 2428 were genotyped by Illumina HumanCNV370v1 Bead Array. The TMMG dataset genotyped by AFFY 6.0 (644,413 SNPs passing quality control checks) was imputed using the phased CEU and TSI samples (566 haplotypes) of the 1000 Genomes project as a reference. (Chen, W., et al., “Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration.” Proc Natl Acad Sci USA 107, 7401-6 (2010)) Separate imputation was performed on the TMMG dataset genotyped on the ILMN 370 (329,315 SNPs passing quality control checks) using the same method. A consensus set of 6,036,699 high quality SNPs from each imputed dataset was analyzed using a generalized linear model controlling for genetic ancestry based on principal component analysis. We observed little statistical inflation in the association statistic after removing known associated loci (see  FIGS. 8   a ,  8   b, λ   gc =1.047). There were highly statistically significant association signals at SNPs in six previously published loci, including ARMS2/HTRA1 (rs10490924, p=2.5×10 −143 ), CFH (rs1061170, p=1.6×10 −136 ) and (rs1410996, p=7.6×10 −133 ), CFB (rs641153, p=7.8×10 −23 ), C3 (rs2230199, p=2.6×10 −19 ), C2 (rs9332739, p=7.6×10 −12 ), CFI (rs10033900, p=8.7×10 −12 ), and LIPC (rs1532085, p=3.2×10 −7 ) ( FIG. 9 ). 
         [0000]    
       
         
               
             
               
               
               
             
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
             
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
             
               
               
               
               
               
               
               
               
               
               
               
               
               
             
           
               
                 TABLE 11 
               
             
             
               
                   
               
               
                 Genes associated with AMD in Genome-wide Meta-analysis and analysis of all samples combined. 
               
             
          
           
               
                   
                 TMMG 
                   
               
               
                   
                 meta-analysis 
               
             
          
           
               
                   
                 Frequency 
                 Imputation 
                   
                 Combined Analysis 
               
             
          
           
               
                 SNP 
                 GENE 
                 CHR 
                 BP 
                 EA #   
                 Cases 
                 Controls 
                 Quality 
                 OR 
                 P 
                 OR 
                 P 
                 Samples 
               
               
                   
               
             
          
           
               
                 Table 11a: Newly identified SNPs associated with AMD susceptibility. 
               
             
          
           
               
                 rs1999930 
                 FRK/ 
                 6 
                 116387134 
                 T 
                 0.260 
                 0.304 
                 0.97 
                 0.81 
                 3.4E−07 
                 0.87 
                 6.8E−08 
                 abcdefgh 
               
               
                   
                 COL10A1 
               
               
                 rs4711751 
                 VEGFA 
                 6 
                 43828582 
                 T 
                 0.535 
                 0.505 
                 0.65 
                 1.21 
                 1.5E−05 
                 1.20 
                 2.0E−11 
                 abdefg 
               
             
          
           
               
                 Table 11b: SNPs previously associated with AMD (genome-wide significant in this study). 
               
             
          
           
               
                 rs10490924 
                 HTRA1 
                 10 
                 124214448 
                 T 
                 0.414 
                 0.206 
                 1.00 
                 3.19 
                 2.5E−143 
                 2.94 
                 4.5E−300 
                 abef 
               
               
                 rs1061170 
                 CFH 
                 1 
                 196659237 
                 C 
                 0.609 
                 0.371 
                 1.00 
                 2.73 
                 1.6E−136 
                 2.51 
                 3.0E−251 
                 abefg 
               
               
                 rs1410996 
                 CFH 
                 1 
                 196696933 
                 C 
                 0.799 
                 0.579 
                 1.00 
                 3.11 
                 7.6E−133 
                 2.90 
                 1.8E−212 
                 abe 
               
               
                 rs641153 
                 CFB 
                 6 
                 31914180 
                 T 
                 0.053 
                 0.101 
                 0.91 
                 0.46 
                 7.8E−23 
                 0.49 
                 7.7E−34 
                 abe 
               
               
                 rs2230199 
                 C3 
                 19 
                 6718387 
                 G 
                 0.244 
                 0.193 
                 0.55 
                 1.71 
                 2.6E−19 
                 1.52 
                 1.7E−19 
                 abe 
               
               
                 rs9332739 
                 C2 
                 6 
                 31903804 
                 C 
                 0.023 
                 0.045 
                 0.89 
                 0.45 
                 7.6E−12 
                 0.50 
                 3.0E−16 
                 abe 
               
               
                 rs10033900 
                 CFI 
                 4 
                 110659067 
                 T 
                 0.520 
                 0.463 
                 0.78 
                 1.32 
                 8.7E−12 
                 1.24 
                 1.5E−13 
                 abe 
               
               
                 rs10468017 
                 LIPC 
                 15 
                 58678512 
                 T 
                 0.257 
                 0.287 
                 0.90 
                 0.84 
                 9.7E−05 
                 0.85 
                 5.3E−09 
                 abcdef 
               
               
                 rs3764261 
                 CETP 
                 16 
                 56993324 
                 A 
                 0.360 
                 0.328 
                 0.97 
                 1.16 
                 1.2E−04 
                 1.16 
                 9.6E−09 
                 abcdef 
               
               
                 rs9621532* 
                 TIMP3 
                 22 
                 33084511 
                 C 
                 0.037 
                 0.051 
                 1.00 
                 0.72 
                 4.9E−04 
                 0.64 
                 6.0E−14 
                 abcdef 
               
               
                   
               
               
                 *The result of this SNP was from imputation data based on Hapmap 2 project, all other SNPs were imputed based on 1000 Genomes project. 
               
               
                   # Effective allele (EA)-frequency and odds ratio based on this SNP for each locus. 
               
               
                 (a) TMMG represents Tufts/MMAP/MIGen/GAIN; 
               
               
                 (b) Iceland represents deCODE genetics sample replication; 
               
               
                 (c) COL represents the Columbia University sample replication; 
               
               
                 (d) JHU represents the Johns Hopkins University sample replication; 
               
               
                 (e) Genentech represents Genentech of the Roche group sample replication, 
               
               
                 (f) WASH-U represents Washington University sample replication; 
               
               
                 (g) AUS represents the Centre for Eye Research Australia sample replication; 
               
               
                 (h) Rotterdam represents the Rotterdam study sample replication. 
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
               
             
           
               
                 TABLE 12 
               
             
             
               
                   
               
               
                 Age-related macular degeneration grade, gender and age information for samples. 
               
             
          
           
               
                   
                 TMMG 
                 TMMG 
                   
                   
                   
                   
                   
                   
                   
               
               
                   
                 (AFFY6.0) 
                 (ILMN370) 
                 JHU 
                 COL 
                 AUS 
                 WASH-U 
                 Genentech 
                 Iceland 
                 Rotterdam 
               
               
                   
                 N (%) 
                 N (%) 
                 N (%) 
                 N (%) 
                 N (%) 
                 N (%) 
                 N (%) 
                 N (%) 
                 N (%) 
               
               
                   
                   
               
             
          
           
               
                 AMD Grade 
                   
                   
                   
                   
                   
                   
                   
                   
                   
               
               
                 1 
                 3058 (71) 
                 1076 (44)  
                 164 (24) 
                 368 (33) 
                 443 (40) 
                 273 (30) 
                 8254 (89) 
                 36949 (98) 
                 4487 (95) 
               
               
                 4 
                  465 (11) 
                 354 (15) 
                 104 (15) 
                 210 (19) 
                 109 (10) 
                 25 (3) 
                  44 (1) 
                  212 (1) 
                  90 (2) 
               
               
                 5 
                  777 (18) 
                 998 (41) 
                 421 (61) 
                 523 (48) 
                 557 (50) 
                 608 (67) 
                  918 (10) 
                  317 (1) 
                 131 (3) 
               
               
                 Gender (N %) 
               
               
                 M 
                 2116 (49) 
                 995 (41) 
                 736 (45) 
                 417 (40) 
                 456 (41) 
                 327 (37) 
                 4000 (45) 
                 16190 (43) 
                 1645 (39) 
               
               
                 F 
                 2184 (51) 
                 1433 (59)  
                 909 (55) 
                 631 (60) 
                 653 (59) 
                 558 (63) 
                 4947 (55) 
                 21288 (57) 
                 2607 (41) 
               
               
                 Mean Age by 
               
               
                 AMD grade 
               
               
                 1 
                 77 
                 74 
                 74 
                 75 
                 71 
                 69 
                 64 
                 54 
                 65 
               
               
                 4 
                 81 
                 79 
                 76 
                 80 
                 71 
                 N/A 
                 70 
                 84 
                 83 
               
               
                 5 
                 81 
                 80 
                 77 
                 79 
                 77 
                 79 
                 73 
                 84 
                 81 
               
               
                   
               
               
                 TMMG (AFFY6.0) represents the genome-wide association data using the Affymetrix 6.0 platform from Tufts Medical Center, Tufts University School of Medicine, with MIGEN and GAIN controls (age not provided); 
               
               
                 TMMG (ILMN370) represents the genome-wide association data using the Illumina 370 platform from the Michigan/Penn/Mayo group; 
               
               
                 JHU represents the Johns Hopkins University sample replication, 
               
               
                 COL represents the Columbia University sample replication, 
               
               
                 AUS represents the Centre for Eye Research Australia sample replication, 
               
               
                 WASH-U represents Washington University sample replication, 
               
               
                 Genentech represents Genentech of the Roche group sample replication, 
               
               
                 Iceland represents deCODE genetics sample replication and Rotterdam represents the Rotterdam study sample replication. 
               
               
                 AMD Grading System: grade 1 represents individuals with no drusen or a few small drusen, 4 represents individuals with central or non-central geographic atrophy (“advanced dry type”), and 5 represents individuals with neovascular disease (“advanced wet type”). 
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
             
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 13 
               
               
                   
               
               
                 The evolution of sample size as a function of the quality control process. 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                   
                 TMMG (AFFY 6.0) 
                 TMMG (ILMN 370) 
               
             
          
           
               
                   
                   
                   
                 Change to 
                   
                   
                   
                 Change to 
                   
               
               
                   
                 Cases 
                 Controls 
                 Sample Size 
                 #SNPs 
                 Cases 
                 Controls 
                 Sample Size 
                 #SNPs 
               
               
                   
               
               
                 Initial Sample 
                 1350 
                 506 
                 — 
                 909622 
                 2159 
                 1150 
                 — 
                 344942 
               
               
                 Addition of Shared MIGEN Controls 
                 1350 
                 1702 
                 1196 
                 909622 
               
               
                 Initial Dataset Cleaning 
                 1290 
                 1686 
                  −76 
                 690987 
                 2159 
                 1150 
                 — 
                 329368 
               
               
                 Addition of Shared GAIN Controls 
                 1290 
                 3064 
                 1378 
                 666964 
               
               
                 Removal of non-advanced cases 
                 1290 
                 3064 
                 — 
                 666964 
                 1623 
                 1150 
                 −536 
                 329368 
               
               
                 Removal of duplicates or relatives 
                 1244 
                 3058 
                  −52 
                 666964 
                 1354 
                 1081 
                 −338 
               
               
                 Secondary Dataset Cleaning 
                 1244 
                 3058 
                 — 
                 644413 
                 1354 
                 1081 
                 — 
                 329315 
               
               
                 Removal of Clustering Outliers 
                 1242 
                 3058 
                  −2 
                 644413 
                 1352 
                 1076 
                  −7 
                 329315 
               
               
                   
               
             
          
           
               
                   
                   
                 Cases 
                 Controls 
                 #SNPs 
                 #SNPs passed QC 
               
               
                   
                   
               
               
                   
                 Combined Sample after imputation 
                 2594 
                 4134 
                 7602146 
                 6036699 
               
               
                   
                   
               
               
                   
                 Each step represents a cleaning stage. The initial sample represents all samples genotyped or retrieved from dbGaP. The initial dataset cleaning encompasses Hardy-Weinberg equilibrium (HWE), call rate and minor allele frequency threshold. The secondary dataset cleaning reapplied all initial dataset cleaning steps after the addition of shared controls and removed SNPs with differential missingness between cases and controls or SNPs with differential frequencies between different genotyping batches on samples of same disease status. Samples with pihat&gt;0.2 based on a pruned genome-wide SNPs were potential relatives or duplicates. One sample of each relative pair was removed. Individuals who did not cluster with the majority of the sample using a principle components population stratification analysis were removed before imputation. Resultant SNPs from imputation were filtered by quality score &gt;0.6 and Minor allele frequency &gt;0.01. 
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
             
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
               
               
               
               
             
           
               
                 TABLE 14 
               
             
             
               
                   
               
               
                 Meta-analysis and Combined analysis results for association with AMD - other candidate SNPs tested. 
               
             
          
           
               
                   
                 TMMG meta-analysis 
                   
               
             
          
           
               
                   
                 Frequency 
                 Imputation 
                   
                 Combined Analysis 
               
             
          
           
               
                 SNP 
                 GENE 
                 CHR 
                 BP 
                 EA #   
                 Cases 
                 Controls 
                 Quality 
                 OR 
                 P 
                 OR 
                 P 
                 Samples 
               
               
                   
               
             
          
           
               
                 rs1883025 
                 ABCA1 
                 9 
                 107664301 
                 T 
                 0.257 
                 0.279 
                 0.95 
                 0.87 
                 1.8E−03 
                 0.87 
                 9.5E−07 
                 abcdefh 
               
               
                 rs13095226 
                 COL8A1 
                 3 
                 99396272 
                 C 
                 0.123 
                 0.104 
                 1.00 
                 1.22 
                 5.9E−04 
                 1.18 
                 1.3E−05 
                 abcdefh 
               
               
                 rs2883171 
                 CDH12 
                 5 
                 21273843 
                 G 
                 0.137 
                 0.116 
                 0.69 
                 1.32 
                 1.6E−05 
                 1.22 
                 1.9E−05 
                 abe 
               
               
                 rs10103808 
                 FAM135B 
                 8 
                 139143072 
                 T 
                 0.115 
                 0.090 
                 0.96 
                 1.31 
                 1.7E−05 
                 1.22 
                 3.3E−05 
                 abe 
               
               
                 rs12040406 
                 C4BPA, CD55 
                 1 
                 207449304 
                 C 
                 0.083 
                 0.094 
                 0.19 
                 0.46 
                 4.6E−07 
                 0.73 
                 9.9E−05 
                 abcdeg 
               
               
                 rs4256145 
                 OTOL1 
                 3 
                 161710141 
                 G 
                 0.306 
                 0.338 
                 0.99 
                 0.84 
                 1.9E−05 
                 0.90 
                 1.3E−04 
                 abe 
               
               
                 rs61856267 
                 PCDH15 
                 10 
                 56710188 
                 G 
                 0.114 
                 0.095 
                 0.67 
                 1.36 
                 4.8E−05 
                 1.27 
                 1.5E−04 
                 abe 
               
               
                 rs4967980 
                 USP31, SCNN1G 
                 16 
                 23183594 
                 C 
                 0.256 
                 0.225 
                 0.93 
                 1.20 
                 4.4E−05 
                 1.14 
                 1.7E−04 
                 abe 
               
               
                 rs12632671 
                 TKT 
                 3 
                 53258424 
                 A 
                 0.068 
                 0.057 
                 0.71 
                 1.45 
                 7.7E−05 
                 1.28 
                 1.9E−04 
                 abe 
               
               
                 rs16965939 
                 TMCO5 
                 15 
                 38204793 
                 T 
                 0.091 
                 0.108 
                 0.51 
                 0.68 
                 3.6E−05 
                 0.80 
                 2.0E−04 
                 abcde 
               
               
                 rs722782 
                 MYOM2 
                 8 
                 516479 
                 A 
                 0.084 
                 0.106 
                 0.99 
                 0.76 
                 1.5E−05 
                 0.85 
                 3.5E−04 
                 abe 
               
               
                 rs1915098 
                 IGSF11 
                 3 
                 118198440 
                 A 
                 0.141 
                 0.166 
                 0.95 
                 0.80 
                 2.7E−05 
                 0.88 
                 5.8E−04 
                 abdefg 
               
               
                 rs72850977 
                 CTSD 
                 11 
                 1811496 
                 A 
                 0.148 
                 0.172 
                 0.79 
                 0.78 
                 7.5E−06 
                 0.87 
                 6.2E−04 
                 abdef 
               
               
                 rs2270637 
                 SLC18A1 
                 8 
                 20036827 
                 G 
                 0.173 
                 0.200 
                 0.99 
                 0.82 
                 4.4E−05 
                 0.88 
                 6.4E−04 
                 abdeh 
               
               
                 rs6531212 
                 SDC1, LAPTM4A 
                 2 
                 20338020 
                 T 
                 0.318 
                 0.351 
                 1.00 
                 0.85 
                 4.3E−05 
                 0.92 
                 6.8E−04 
                 abcdef 
               
               
                 rs11755724 
                 RREB1 
                 6 
                 7118990 
                 A 
                 0.343 
                 0.372 
                 1.00 
                 0.88 
                 9.3E−04 
                 0.93 
                 1.1E−03 
                 abcdefg 
               
               
                 rs17628762 
                 CELF4 
                 18 
                 35871719 
                 A 
                 0.382 
                 0.343 
                 0.98 
                 1.19 
                 8.3E−06 
                 1.08 
                 4.6E−03 
                 abcdef 
               
               
                 rs10280782 
                 TRA2A, CLK2P 
                 7 
                 23584282 
                 G 
                 0.123 
                 0.151 
                 0.99 
                 0.77 
                 2.4E−06 
                 0.91 
                 6.4E−03 
                 abcdefg 
               
               
                 rs2127740 
                 PSMD7 
                 16 
                 73732309 
                 A 
                 0.139 
                 0.114 
                 0.96 
                 1.29 
                 1.0E−05 
                 1.14 
                 6.4E−03 
                 abe 
               
               
                 rs1789110 
                 MBP 
                 18 
                 74859044 
                 C 
                 0.413 
                 0.375 
                 0.89 
                 1.21 
                 2.3E−06 
                 1.07 
                 2.5E−02 
                 abcdef 
               
               
                 rs12926103 
                 FOXF1 
                 16 
                 86371775 
                 A 
                 0.066 
                 0.057 
                 0.79 
                 1.44 
                 2.9E−05 
                 1.17 
                 9.2E−02 
                 abe 
               
               
                   
               
               
                 (a) TMMG; 
               
               
                 (b) ICELAND; 
               
               
                 (c) COL; 
               
               
                 (d) JHU; 
               
               
                 (e) Genentech; 
               
               
                 (f) Wash-U; 
               
               
                 (g) AUS; 
               
               
                 (h) ROT. (see Table 12.) 
               
               
                   # Effective allele (EA)-frequency and odds ratio based on this SNP for each locus. 
               
             
          
         
       
     
         [0000]    
       
         
               
             
               
               
               
               
             
               
               
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
               
               
               
             
           
               
                 TABLE 15 
               
             
             
               
                   
               
               
                 Association results of some published candidate SNPs not showing 
               
               
                 significant evidence of association in TMMG. 
               
             
          
           
               
                   
                 Frequency 
                 Imputation 
                   
               
             
          
           
               
                 Reference 
                 SNP 
                 GENE 
                 CHR 
                 BP 
                 EA #   
                 Cases 
                 Controls 
                 Quality 
                 OR 
                 P 
               
               
                   
               
             
          
           
               
                 1 
                 rs2290465 
                 VLDLR 
                 9 
                 2645201 
                 C 
                 0.817 
                 0.81 
                 0.515 
                 1.08 
                 0.252 
               
               
                 1 
                 rs2010963 
                 VEGF 
                 6 
                 43738350 
                 C 
                 0.341 
                 0.338 
                 0.899 
                 1.05 
                 0.258 
               
               
                 1 
                 rs7294695 
                 LRP6 
                 12 
                 12323618 
                 C 
                 0.532 
                 0.539 
                 0.954 
                 0.983 
                 0.649 
               
               
                 2 
                 rs3775291 
                 TLR3 
                 4 
                 187004074 
                 T 
                 0.306 
                 0.294 
                 0.981 
                 1.03 
                 0.479 
               
               
                 3 
                 rs4986790 
                 TLR4 
                 9 
                 120475302 
                 A 
                 0.938 
                 0.939 
                 0.911 
                 0.963 
                 0.634 
               
               
                 4 
                 rs2511989 
                 SERPING1 
                 11 
                 57378325 
                 T 
                 0.399 
                 0.398 
                 1 
                 1.02 
                 0.648 
               
               
                 5 
                 rs3732378 
                 CX3CR1 
                 3 
                 39307162 
                 A 
                 0.172 
                 0.168 
                 0.905 
                 1.02 
                 0.715 
               
               
                 5 
                 rs3793784 
                 ERCC6 
                 10 
                 50747539 
                 C 
                 0.412 
                 0.411 
                 0.977 
                 0.998 
                 0.957 
               
               
                 6 
                 rs4073 
                 IL8 
                 4 
                 74606024 
                 A 
                 0.454 
                 0.449 
                 0.984 
                 1.01 
                 0.788 
               
               
                   
               
               
                 1. Haines JL, et al. (2006) Functional candidate genes in age-related macular degeneration: significant association with VEGF, VLDLR, and LRP6. Invest Ophthalmol Vis Sci 47: 329-335. 
               
               
                 2. Yang Z, et al. (2008) Toll-like receptor 3 and geographic atrophy in age-related macular degeneration. N Engl J Med 359: 1456-1463. 
               
               
                 3. Zareparsi S, et al. (2005) Toll-like receptor 4 variant D299G is associated with susceptibility to age-related macular degeneration. Hum Mol Genet 14: 1449-1455. 
               
               
                 4. Ennis S, et al. (2008) Association between the SERPING1 gene and age-related macular degeneration: a two-stage case-control study. Lancet 372: 1828-1834. 
               
               
                 5. Tuo J, et al. (2004) The involvement of sequence variation and expression of CX3CR1 in the pathogenesis of age-related macular degeneration. FASEB J 18: 1297-1299. 
               
               
                 6. Goverdhan SV, et al. (2008) Interleukin-8 promoter polymorphism −251A/T is a risk factor for age-related macular degeneration. Br J Ophthalmol 92: 537-540. 
               
               
                   # Effective allele (EA)-frequency and odds ratio based on this SNP for each locus. 
               
             
          
         
       
     
         [0076]    Additional methods for marker discovery and validation also were used. Briefly, the Tufts/MGH replication dataset was comprised of DNA samples from unrelated Caucasian individuals not included in the GWAS, including 868 advanced AMD cases and 410 examined controls who were identified from the same Tufts cohorts, and 379 unexamined MGH controls. 
         [0077]    The GWAS genotyping and the Tufts/MGH follow-up replication genotyping were performed at the Broad and National Center for Research Resources (NCRR) Center for Genotyping and Analysis using the Affymetrix SNP 6.0 GeneChip and the Sequenom MassARRAY system for iPLEX assays, respectively. Initially, a primary dataset of 1,057 cases and 558 was examined controls and studied 906,000 genotyped SNPs and 946,000 CNVs using the Affymetrix 6.0 GeneChip which passed quality control filters. Then 43,562 SNPs were removed for low call rate, 4,708 were removed for failing Hardy-Weinberg test at 10-3, and 8,332 SNPs were removed because of failing a differential missing test between cases and controls at 10-3. Finally, 126,050 SNPs were removed for having allele frequency less than 1%, similar to other studies using this methodology. Thus, 726,970 SNPs were evaluated in this study in the discovery phase. 73 individuals were removed for lower than expected call rate, resulting in 1,006 cases and 536 controls. All quality control steps were performed using PLINK. A preliminary χ2 association analysis was conducted to determine the extent to which population stratification and other biases were affecting the samples and observed a lambda of ˜1.05, indicating that the samples were generally well matched for population ancestry, with some minor inflation remaining (explanation and visual representation see  FIGS. 3A &amp; 3B ). MIGEN shared controls were added, which were genotyped on the same Affymetrix 6.0 GeneChip® product, and population stratification analyses were conducted using multi-dimensional scaling in PLINK. These analyses identified 27 cases, 12 AMD controls and 223 MIGEN controls for a total of 262 individuals which were outliers in the principal component analysis. The final genomic control lambda for the logistic regression included seven significant (for prediction of phenotype status) principal components as covariates and was 1.036 for 632,932 SNPs. This dataset was used for our official GWAS analysis. 
         [0078]    SNPs with P&lt;10-3 were evaluated from the GWAS discovery sample (n=720 SNPs excluding previously associated regions) in the MPM GWAS. The exchange of top hits enabled us to use the two scans as primary replication efforts which enhanced the power of each study. Genotyping was performed of all SNPs with combined P&lt;10-4 using Sequenom iPLEX™ at the Broad NCRR Genotyping Center using our Tufts/MGH replication sample. Focusing on sites which continued to show association with P&lt;10-4 after this local replication, a third stage of replication was performed with collaborators in Iceland (deCode Genetics database). For this study, P values were calculated for the combined imputed dataset and for all of our top hits comparing AMD to controls (N=130). Other groups were asked to check these SNPs in their GWAS data—including Iceland (deCode Genetics database) and Genentech—and they sent their data for these SNPs, which were then added to our analyses. To validate the discovery of these SNPs, other groups also were asked to genotype SNPs of interest in their samples using either TaqMan or Sequenom as part of the replication. These data were received as well and combined values were calculated based on the frequencies, of the alleles in the various AMD groups—the total advanced AMD case group, as well as the different advanced phenotypes, called geographic atrophy and neovascular AMD. P values for association between these various alleles, genotypes and different AMD case groups were calculated. SNPs associated with geographic atrophy and neovascular disease were studied and these groups were compared to each other, to determine which are associated with one advanced subtype versus the other. 20 SNPs were identified in this comparison (Table 5), and these SNPs were also sent to the same groups noted above, for replication. 
         [0079]    To augment the control set, a subset of controls (n=1409) from the Myocardial Infarction Genetics (MIGEN) Project was used. Briefly, MIGEN controls are ascertained across Europe, for absence of an MI event. These controls are unscreened for AMD, and so the utility of including them was assessed by examining the previously reported associations in the literature. Specifically, an assessment as to whether the loci at CFH, ARMS2, CFI, C3, CF/B2 showed more significant association to AMD upon expansion of the control sample was performed. The inclusion of these shared controls yielded a dramatic increase in the lambda (2.2). Multi-dimensional scaling was applied based on all pair-wise identity-by-state comparisons for all individuals. The first multi-dimensional scaling component separated out completely the shared controls from the initial dataset ( FIG. 3A ). American populations can be matched to European populations (as long the European populations are diverse), so this complete delineation between the shared controls and the original dataset was due to technical bias between the two datasets. Moving the call rate threshold from 95% to 99% dramatically reduced the lambda (1.22), but still, apparent population stratification effects persisted. Multi-dimensional scaling was again applied to the IBS matrix, examining the first 10 axes of variation. The first axis of variation no longer classified the cases and controls. The second axis of variation identified a handful of individuals who were apparently either demonstrating high levels of technical bias or were from a different ancestral background ( FIG. 3B ). Finally, the axes of variation were examined to determine whether they significantly predicted case or control status across the genome at an average P-value less than 0.05. Doing so yielded 7 axes of variation and a lambda of 1.036, comparable to the initial study lambda, with an expanded sample size. 
         [0000]    
       
         
               
             
               
               
               
               
               
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 1 
               
             
             
               
                   
               
               
                 Age-related macular degeneration grade, 
               
               
                 gender and age information for samples. 
               
             
          
           
               
                   
                 Tufts/MGH 
                 UM 
                 Tufts/MGH 
                   
                   
               
               
                   
                 Affy 
                 ILMN 
                 Replication 
                 JHU 
                 NY 
               
               
                   
                 N (%) 
                 N (%) 
                 N (%) 
                 N (%) 
                 N (%) 
               
               
                   
                   
               
             
          
           
               
                 AMD 
                   
                   
                   
                   
                   
               
               
                 Grade 
               
               
                 1 
                 524 (35) 
                 1138 (44) 
                 410 (32) 
                 136 (22) 
                 368 (33) 
               
               
                 4 
                 269 (18) 
                  415 (16) 
                 246 (19) 
                  95 (15) 
                 211 (19) 
               
               
                 5 
                 710 (47) 
                 1037 (40) 
                 622 (49) 
                 389 (63) 
                 524 (48) 
               
               
                 Gender 
               
               
                 (N %) 
               
               
                 M 
                 691 (46) 
                 1062 (41) 
                 513 (40) 
                 209 (34) 
                 418 (40) 
               
               
                 F 
                 812 (54) 
                 1528 (59) 
                 765 (60) 
                 411 (66) 
                 632 (60) 
               
               
                 Mean 
               
               
                 Age by 
               
               
                 AMD 
               
               
                 grade 
               
               
                 1 
                 76 
                 74 
                 73 
                 74 
                 75 
               
               
                 4 
                 81 
                 78 
                 79 
                 76 
                 80 
               
               
                 5 
                 80 
                 80 
                 80 
                 77 
                 79 
               
               
                   
               
             
          
         
       
     
         [0080]    Tufts/MGH Affy represents the genome-wide association scan using the Affymetrix 6.0 platform from Tufts Medical Center, Tufts University School of Medicine, without the MIGEN controls included; Tufts/MGH Replication represents the follow up replication pool at MGH/Tufts; UM ILMN represents the genome-wide association scan using the Illumina 322 platform from the University of Michigan; JHU represents the Johns Hopkins University sample replication, and NY represents the Columbia University sample replication. AMD Grading System: grade 1 represents individuals with no drusen or a few small drusen, 4 represents individuals with central or non-central geographic atrophy (“advanced dry type”), and 5 represents individuals with neovascular disease (“advanced wet type”). 
         [0000]    
       
         
               
             
               
               
               
               
               
             
               
               
               
               
               
             
           
               
                 TABLE 2 
               
             
             
               
                   
               
               
                 The evolution of sample size as a function 
               
               
                 of the quality control process. 
               
             
          
           
               
                   
                   
                   
                 Change to 
                   
               
               
                   
                 Cases 
                 Controls 
                 Sample Size 
                 #SNPs 
               
               
                   
                   
               
             
          
           
               
                 Initial Sample 
                 1057 
                 558 
                 — 
                 909622 
               
               
                 Initial Dataset Cleaning 
                 1006 
                 536 
                 −73 
                 726970 
               
               
                 Addition of Shared Controls 
                 1006 
                 1944 
                 1409 
                 707919 
               
               
                 Removal of Clustering 
                 979 
                 1709 
                 −262 
                 632932 
               
               
                 Outliers 
               
               
                   
               
             
          
         
       
     
         [0081]    Each step represents a cleaning stage. The initial sample represents all samples genotyped. The initial dataset cleaning encompasses HWE, call rate, differential missingness between cases and controls, and minor allele frequency threshold. Adding in shared controls, the call rate and MAF thresholds were reapplied. For the final stage, call rate of 99% was required as was the removal of individuals who did not cluster with the majority of the sample. 
       Results 
       [0082]    Case and Control Sample Development. 
         [0083]    The initial study consisted of 1,057 unrelated cases with geographic atrophy or neovascular AMD, and 558 unrelated controls without AMD who were phenotyped based on clinical examination and ocular photography, and identified from studies of genetic-epidemiology of macular degeneration at Tufts Medical Center. The AMD grade in the worst eye was used in the analyses. All individuals were Caucasian from European ancestry (further details about the original and replication study populations can be found in METHODS and Table 1). 
         [0084]    To enhance the power of this study, unrelated control resources that were genotyped on the same platform in the same lab were included, and additional stringent quality control to ensure the technical and population compatibility of these datasets was conducted (METHODS and Table 2). The final genotyped sample consisted of 979 cases and 1,709 controls. Using a logistic regression analysis including population structure covariates, genomic control inflation factors were comparable between the initial, similarly ascertained sample and the expanded sample, suggesting that potential population differences have been controlled appropriately (979 cases to 536 controls lamba=1.051; 979 cases to 1,709 controls lambda=1.036). Because these additional controls were unscreened for AMD status and may include individuals who have or might later develop AMD, their impact on established associations was determined. The most compelling previously reported associated regions in AMD: CFH on chromosome 1, CFI on chromosome 4, BF/C2 on chromosome 6, ARMS2/HTRA1 on chromosome 10, and C3 on chromosome 19 were examined. 159 SNPs that were in LD with the most positively associated variant reported in the literature were examined. Of these, 137 showed an improvement in the χ 2 , with the addition of these controls. The average ratio of the initial study&#39;s cleaned χ 2  to final study&#39;s cleaned χ 2  was 1.82—nearly identical to the expected improvement in χ 2  based on theoretical power calculations of 1.84. As predicted, the addition of a significant number of unselected controls increased the power of this study substantially. 
         [0085]    Genome-Wide Association Discovery Phase. 
         [0086]    Using a case-control analysis as implemented in PLINK, no SNPs in regions not already reported as being associated with AMD achieved genome-wide significance of 5×10 −8  as defined by Pe&#39;er et al. Several SNPs of interest in regions without previously reported association with P-values between 10 −4  to 10 −6  were identified in the discovery scan (Tables 3, 4, and 5), including rs4711751 (VEGFA) with p=2.66e-5, and rs6982567 (GDF6) with p=6.14e-6, as discussed in more detail below. 
         [0087]    Replication Phases. To evaluate the top results from novel regions identified by the scan, several stages of replication analysis were performed. For all SNPs with p&lt;10 −3  in the genome-wide association scan, results were obtained from the Michigan, Penn, and Mayo scan, selecting only their advanced cases versus controls, and combined the study results as equally weighted-Z scores given the similar sample sizes. From this combined analysis, SNPs with p&lt;10 −4  or higher in our independent local replication sample of advanced cases and controls from Tufts University School of Medicine and Massachusetts General Hospital (Tufts/MGH) were genotyped, who were unrelated to the individuals in our original scan. Not all SNPs could be imputed perfectly in the Michigan scan, given the different sizes and types of genotyping platforms used (Affymetrix 6.0 with 906,000 SNPS and Illumina with 320,000 SNPS). Therefore, a subset of strongly associated SNPs from the scan alone were selected to be genotyped in the local replication sample. After these steps, a subset of promising SNPs were distributed to collaborators at Iceland (DeCode database) and Genentech, for replication in independent samples. A tally of these P-values for the discovery and local replication stages are presented in Tables 3, 4, and 5. Additional identified SNPs are presented in Tables 6, 7, 8, 9, and 10. 
         [0088]    Results of Combined Scan and Replication Analysis. 
         [0089]    A SNP on chromosome 6, rs4711751 (VEGFA), showed significant association with p=2.66e-5, and a SNP on chromosome 8, rs6982567 (GDF6), showed significant association with a p=6.14e-6. In addition, a different VEGFA SNP, rs943080, is reportedly in LD with this SNP (paper forthcoming) and is about 1950 by from rs6982567. The genome-wide association study results disclosed herein revealed numerous additional SNPs that are associated with AMD (Tables 3, 4, 5, 6, 7, 8, 9, and 10). The nucleic acid sequence corresponding to each reference SNP (rs) number listed in Tables 3, 4, 5, 6, 7, 8, 9, and 10 is incorporated by references herein. 
         [0090]    Thus, rs4711751, rs6982567, a SNP listed in Tables 3, 4, 5, 6, 7, 8, 9, and 10, and/or a marker in linkage disequilibrium with one of these SNPs can be used in accordance with the present invention as markers for AMD etiology, for determining susceptibility to AMD, and for predicting disease progression or severity, and for distinguishing risk of geographic atrophy, the advanced dry type of AMD from the advanced wet form of AMD. In addition, any marker in LD with one of these markers can be used as a surrogate marker for AMD etiology, for determining susceptibility to AMD, and for predicting disease progression or severity. 
         [0091]    Excluding previously published genetic regions associated with AMD, we detected a region on 6q21-q22.3 ( FIG. 6   a ) containing 30 SNPs with p&lt;5×10 −7  in the TMMG sample.  FIGS. 6   a - d  show the FRK/COL10A1 region and association with AMD.  FIG. 6   a  shows observed association in the 500-kb region surrounding the FRK/COL10A1 locus in meta-analysis of TMMG datasets. The represented SNP (rs1999930) for this region of P=3.4×10 −7  was shown by small purple diamond (see arrow). In the combined analysis including all 8 cohorts this SNP was associated with AMD at P=6.8×10 −8  (large purple diamond; see arrow).  FIG. 6   b  shows Forest plot for rs1999930 association across 8 Cohorts.  FIG. 6   c  shows observed association in the 500-kb region surrounding the VEGFA (rs4711751) locus in meta-analysis of TMMG datasets. In the combined analysis including all 6 cohorts this SNP was associated with AMD at P=2.0×10 −11  (large purple diamond; see arrow).  FIG. 6   d  shows Forest plot for rs4711751 association across 6 cohorts. 
         [0092]    Since all of these SNPs are in a tight LD block (r 2 &gt;0.8), we chose to investigate the association in this region through rs1999930. The minor T allele frequency of rs1999930 was 26.0% in cases and 30.5% in controls (Table 11) for the TMMG sample, with an odds ratio (OR) of 0.81, and 95% confidence interval (CI) 0.77-0.84. To confirm this new locus for AMD, we tested rs1999930 in a total of 4269 independent cases and 50,938 independent controls of European ancestry from Johns Hopkins University (JHU), Columbia University (COL), Genentech, Decode, Washington University (Wash-U), Centre for Eye Research Australia (AUS), Rotterdam (ROT), and Hopital Intercommunal de Creteil (FR-CRET) (Table 12). Frequency and risk associated with the minor allele T of rs1999930 in each replication cohort were all in the same direction as in TMMG ( FIG. 6   b ). 
         [0093]    Combining the test statistics of all independent replication cohorts weighted by their sample size using Stouffer&#39;s Z-score method, this association was confirmed (OR=0.91, P=0.0057). The results were very consistent across datasets with no significant evidence for heterogeneity under the Cochran&#39;s Q-test for our samples (Q=0.09, I 2 =44[0-75]). In the combined analysis of all the samples, the T allele of rs1999930 significantly (p=6.8×10 −8 ) reduced the risk of AMD (OR=0.87 [0.83-0.92]). This associated region represented by rs1999930 contains the genes COL10A1 (encoding the alpha chain of type X collagen) and FRK (encoding fyn-related kinase). 
         [0094]    We also tested other unreported loci for AMD with p-value&lt;5×10 −5  in the TMMG meta-analysis (Table 14) and several previously reported loci (Table 11) with suggestive association results. The risk variants in TIMP3 (rs9621532, p=6×10 −14 ) and HDL pathway genes LIPC (rs10468017, p=5.3×10 −9 ), CETP (rs3764261, p=9.6×10 −9 ) were genome-wide significant in our combined analysis and a previously suggestive association in ABCA1 (rs1883025, p=9.5×10 −7 ) was still noteworthy. Another locus near C4BPA/CD55 gene was suggested from the TMMG analysis (P=4.6×10 −7 ), however, the combined p-value was 9.9×10 −5 . 
         [0095]    Among the other previously unreported loci, the T allele of one candidate SNP (rs4711751) near VEGFA, was associated with increased risk of AMD (OR=1.21 [1.16-1.27], p=1.5×10 −5 ) in the TMMG meta-analysis and the results were very consistent in direct genotyping replication in 3277 cases and 42091 controls (OR=1.20 (1.15-1.24), p=2.9×10 −7 ). This SNP reached genome-wide significance (OR=1.20 [1.17-1.24], p=2.0×10 11 ) in the combined analysis including all replication cohorts ( FIGS. 6   c ,  6   d ). This novel association with VEGFA was also found in a parallel meta-analysis on a SNP (rs943080, R 2 =1, D′=1) in LD with rs4711751. Our newly identified SNPs is 3′ downstream of VEGFA and more than 90 kb away from the SNP in VEGFA promoter region (rs2010963), which was reported to be associated with AMD previously (Table 15). The rs2010963 allele is in very low LD with rs4711751 (R 2 =0.015, D′=0.138); therefore the association we identified in VEGFA was in a novel region and not likely due to LD with SNPs in the VEGFA promoter region. Of note, the previously reported rs2010963 SNP showed little evidence of association in our TMMG meta-analysis (p=0.26). 
         [0096]    VEGFA which is a member of the vascular endothelial growth factor family increases vascular permeability, angiogenesis, cell growth and migration of endothelial cells. VEGFA has been a major candidate for AMD risk and it has been hypothesized that activation of this gene may induce pathologic angiogenesis under the retinal epithelial (RPE). Interestingly, Rajpar et al. described creating a knock-in mouse for COL10A1 p.Asn617Lys (possible human SNP rs61745148) which reduced the VEGF expression in hypertrophic chondrocytes leading to a significant reduction in the recruitment of osteoclasts to the vascular invasion front. (Rajpar, M. H., et al., “Targeted induction of endoplasmic reticulum stress induces cartilage pathology.” PLoS Genet 5, e1000691 (2009)) 
         [0097]    Furthermore, hypoxia-inducible factor-2α (HIF-2α, encoded by EPAS1) was shown to enhance promoter activities of COL10A1, MMP13 and VEGFA through specific binding to the respective hypoxia-responsive elements. (Saito, T. et al., “Transcriptional regulation of endochondral ossification by HIF-2alpha during skeletal growth and osteoarthritis development.” Nat Med 16, 678-86 (2010)) Hypoxia is known to increase VEGF transcription, translation, and mRNA stability because VEGFA is extremely sensitive to oxygen levels. VEGFA signaling of the Akt pathway can be antagonized by transpondin-1 (TSP-1) which can modulate the remodeling of the microvascular network of the developing retina. FRK has been shown to have negative function on the stimulation of microvascular survival by mediating the downstream signaling of TSP1 and the TSP receptor (CD36). (Sun, J. et al., “Thrombospondin-1 modulates VEGF-A-mediated Akt signaling and capillary survival in the developing retina.” Am J Physiol Heart Circ Physiol 296, H1344-51 (2009)) It is quite possible that this SNP or set of SNPs in the region directly affect the expression of VEGF through either or both COL10A1 and FRK signaling. 
         [0098]    We also investigated the specific association with geographic atrophy (GA) and neovascular (NV) subtypes of AMD in our TMMG samples respectively. Association signals on CFH, C2, CFB, C3, CFI and ARMS2/HTRA1 were also highly significant for both GA and NV compared to controls. The minor allele (T) of rs1999930 had a similar effect size for GA (OR=0.78 [0.69-0.89], P=1.0×10 −4 ) and NV (OR=0.82 [0.75-0.90], P=4.1×10 −5 ). The risk allele (T) of rs4711751 also had a similar magnitude of effect on GA (OR=1.23 [1.08-1.40], P=2.0×10 −3 ) and NV (OR=1.20 [1.09-1.32], P=2.5×10 −4 ). 
         [0099]    We found two novel associated loci near FRK/COL10A1 and VEGFA, and confirmed associations for ten previously published AMD loci in our combined analysis. The genetic loci associated with AMD suggest that the disease process may be explained in part by pathological activation of the alternative complement pathway (CFH, C2, CFB, C3, CFI), the imbalance of HDL cholesterol metabolism (LIPC, CETP, ABCA1) and possibly angiogenesis (VEGFA) induced by dysfunction or degradation of extracellular matrix (COL10A1, FRK, ARMS2, TIMP3). 
         [0100]    The use of headings and sections in the application is not meant to limit the invention; each section can apply to any aspect, embodiment, or feature of the invention. 
         [0101]    Throughout the application, where compositions are described as having, including, or comprising specific components, or where processes are described as having, including or comprising specific process steps, it is contemplated that compositions of the present teachings also consist essentially of, or consist of, the recited components, and that the processes of the present teachings also consist essentially of, or consist of, the recited process steps. 
         [0102]    In the application, where an element or component is said to be included in and/or selected from a list of recited elements or components, it should be understood that the element or component can be any one of the recited elements or components and can be selected from a group consisting of two or more of the recited elements or components. Further, it should be understood that elements and/or features of a composition, an apparatus, or a method described herein can be combined in a variety of ways without departing from the spirit and scope of the present teachings, whether explicit or implicit herein. 
         [0103]    The use of the terms “include,” “includes,” “including,” “have,” “has,” or “having” should be generally understood as open-ended and non-limiting unless specifically stated otherwise. 
         [0104]    The use of the singular herein includes the plural (and vice versa) unless specifically stated otherwise. Moreover, the singular forms “a,” “an,” and “the” include plural forms unless the context clearly dictates otherwise. In addition, where the use of the term “about” is before a quantitative value, the present teachings also include the specific quantitative value itself, unless specifically stated otherwise. 
         [0105]    It should be understood that the order of steps or order for performing certain actions is immaterial so long as the present teachings remain operable. Moreover, two or more steps or actions may be conducted simultaneously. 
         [0106]    Where a range or list of values is provided, each intervening value between the upper and lower limits of that range or list of values is individually contemplated and is encompassed within the invention as if each value were specifically enumerated herein. In addition, smaller ranges between and including the upper and lower limits of a given range are contemplated and encompassed within the invention. The listing of exemplary values or ranges is not a disclaimer of other values or ranges between and including the upper and lower limits of a given range. 
         [0107]    The aspects, embodiments, features, and examples of the invention are to be considered illustrative in all respects and are not intended to limit the invention, the scope of which is defined only by the claims. Other embodiments, modifications, and usages will be apparent to those skilled in the art without departing from the spirit and scope of the claimed invention. 
         [0000]    
       
         
               
               
               
               
               
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 3 
               
               
                   
               
               
                   
                   
                   
                   
                 P_1vs45 —   
                   
               
               
                 SNP 
                 GENE 
                 EA 
                 OR(EA) 
                 Tufts_MPM 
                 Meta_P 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                 rs4711751 
                 VEGFA 
                 T 
                 1.22 
                 2.7E−05 
                 4.3E−11 
               
               
                 rs6982567 
                 GDF6 
                 T 
                 1.32 
                 6.1E−06 
                 3.6E−07 
               
               
                 rs9366769 
                 HCG27(0) 
                 C 
                 0.80 
                 9.4E−06 
                 6.8E−07 
               
               
                 rs1999930 
                 FRK 
                 T 
                 0.81 
                 2.2E−06 
                 1.6E−06 
               
               
                 rs2270637 
                 SLC18A1 
                 G 
                 0.81 
                 5.4E−05 
                 3.8E−06 
               
               
                 rs13278062 
                 TNFRSF10A(+0.332 kb)|CHMP7(−18.18 
                 T 
                 1.22 
                 5.0E−05 
                 3.8E−06 
               
               
                   
                 kb) 
               
               
                 rs7720497 
                 ADAMTS16 
                 G 
                 1.45 
                 2.1E−05 
                 5.8E−06 
               
               
                 chr1:163986967 
                 TMCO1(0) 
                 T 
                 0.57 
                 5.4E−05 
                 7.8E−06 
               
               
                 rs1443179 
                 INTU 
                 T 
                 1.66 
                 1.4E−06 
                 8.9E−06 
               
               
                 rs513683 
                 P4HA3(0) 
                 C 
                 0.85 
                 7.6E−05 
                 1.4E−05 
               
               
                 rs7626245 
                 FILIP1L(0)|C3orf26(0) 
                 C 
                 1.36 
                 6.6E−05 
                 1.6E−05 
               
               
                 rs12632105 
                 RHO(−139 kb)|MBD4(−41.36 kb)|IFT122(−50.53 
                 C 
                 1.25 
                 8.1E−05 
                 2.0E−05 
               
               
                   
                 kb)|H1FX(+73.32 kb)|COPG(−111.8 kb) 
               
               
                 rs2052572 
                 TSHZ3(+107.3 kb) 
                 A 
                 1.19 
                 4.4E−05 
                 2.3E−05 
               
               
                 rs6587759 
                 ZNF692(+10.26 kb)|SH3BP5L(+43.38 kb) 
                 A 
                 1.44 
                 4.2E−05 
                 3.6E−05 
               
               
                   
                 |PGBD2(−36.91 kb)| 
               
               
                 chr22:33891064 
                 ISX(+77.68 kb)|HMG2L1(−92.42 kb) 
                 T 
                 0.51 
                 9.9E−06 
                 4.3E−05 
               
               
                 rs16965939 
                 TMCO5 
                 T 
                 0.64 
                 1.1E−06 
                 4.5E−05 
               
               
                 rs3760775 
                 FUT3 
                 T 
                 0.66 
                 1.3E−05 
                 5.1E−05 
               
               
                 chr12:8919954 
                 A2ML1(0) 
                 T 
                 0.48 
                 4.7E−05 
                 5.4E−05 
               
               
                 rs10103808 
                 FAM135B(0) 
                 T 
                 1.34 
                 1.9E−05 
                 7.1E−05 
               
               
                 chr2:180796214 
                 KIAA1604(+216.2 kb) 
                 A 
                 0.81 
                 3.9E−05 
                 8.6E−05 
               
               
                 rs2883171 
                 CDH12(−477.3 kb) 
                 G 
                 1.29 
                 7.2E−05 
                 8.7E−05 
               
               
                 rs2037156 
                 EPHA7(−434.6 kb) 
                 G 
                 1.27 
                 7.9E−06 
                 1.1E−04 
               
               
                 rs6531212 
                 WDR35(+148.1 kb)|TTC32(+236.3 kb)|S 
                 T 
                 0.83 
                 2.1E−05 
                 1.3E−04 
               
               
                   
                 DC1(−62.54 kb)|PUM2(−110.4 
               
               
                   
                 kb)|MATN3(+125.6 kb)|LAPTM4A(+86.58 kb) 
               
               
                 rs2798832 
                 TAF3(+129.4 kb)|KIN(+356.1 kb)|ITIH2(+394.6 
                 T 
                 1.22 
                 5.5E−05 
                 1.3E−04 
               
               
                   
                 kb)|ITIH5(+477.2 kb)|GATA3(+68.93 
               
               
                   
                 kb)|FLJ45983(+90.65 kb)|ATP5C1(+336.3 kb) 
               
               
                 rs8053796 
                 CNTNAP4 
                 T 
                 1.27 
                 4.4E−06 
                 1.6E−04 
               
               
                 rs1851808 
                 MRPL19(+489.6 kb) 
                 G 
                 1.20 
                 2.7E−05 
                 2.2E−04 
               
               
                 rs10067691 
                 SDCCAG10(0) 
                 A 
                 0.67 
                 1.7E−05 
                 2.4E−04 
               
               
                 chr10:57479107 
                 ZWINT(−308.1 kb) 
                 A 
                 1.29 
                 8.3E−05 
                 2.4E−04 
               
               
                 rs728371 
                 MOXD1(−134.9 kb)|CTGF(+209.8 kb) 
                 A 
                 1.23 
                 4.7E−06 
                 2.4E−04 
               
               
                 rs4967980 
                 USP31(+23 kb)|UBFD1(−385.3 
                 C 
                 1.23 
                 3.9E−05 
                 2.5E−04 
               
               
                   
                 kb)|SCNN1B(−130 kb)|SCNN1G(−10.45 
               
               
                   
                 kb)|COG7(−216.2 kb) 
               
               
                 rs1540819 
                 LSAMP(+563.4 kb) 
                 T 
                 1.17 
                 9.7E−05 
                 2.8E−04 
               
               
                 rs529478 
                 NEDD4L(0) 
                 T 
                 0.83 
                 3.3E−05 
                 2.8E−04 
               
               
                 rs1915098 
                 IGSF11(−421 kb) 
                 A 
                 0.78 
                 2.7E−06 
                 2.9E−04 
               
               
                 chr4:86206508 
                 WDFY3(+99.94 kb) 
                 T 
                 0.61 
                 6.9E−05 
                 3.0E−04 
               
               
                 chr5:113645446 
                 KCNN2(−80.47 kb) 
                 G 
                 1.29 
                 5.5E−05 
                 3.2E−04 
               
               
                 chr11:124212812 
                 ROBO3(−27.68 kb)|C11orf61(+37.3 kb) 
                 T 
                 1.60 
                 6.7E−05 
                 3.5E−04 
               
               
                 rs12520598 
                 GCNT4(+22.83 kb)|HMGCR(−283.5 kb) 
                 T 
                 0.70 
                 4.2E−05 
                 3.5E−04 
               
               
                 rs11067403 
                 TBX3(+404 kb) 
                 C 
                 0.84 
                 5.7E−05 
                 3.8E−04 
               
               
                 chr5:149749881 
                 TCOF1(0) 
                 C 
                 1.38 
                 9.2E−05 
                 3.9E−04 
               
               
                 rs1079982 
                 ANKRD54, CARD10, CARMA3, CDC42E 
                 T 
                 0.65 
                 3.0E−06 
                 4.0E−04 
               
               
                   
                 P1, FLJ00017, GALR3, GCAT, GGA1, H1F 
               
               
                   
                 0, LGALS1, LGALS2, LRRC62, MFNG, NO 
               
               
                   
                 L12, PDXP, PSCD4, RAC2, SH3BP1, TRIO 
               
               
                   
                 BP 
               
               
                 rs12908430 
                 GANC(0) 
                 A 
                 0.71 
                 5.3E−05 
                 4.2E−04 
               
               
                 rs4256145 
                 OTOL1(+488.4 kb) 
                 G 
                 0.84 
                 3.6E−05 
                 4.7E−04 
               
               
                 chr8:123521912 
                 ZHX2(−341.2 kb) 
                 A 
                 1.78 
                 3.6E−05 
                 4.7E−04 
               
               
                 rs9328048 
                 IRF4(−675.1 kb) 
                 T 
                 0.78 
                 2.3E−06 
                 4.9E−04 
               
               
                 chr1:59476907 
                 FGGY(−58.3 kb) 
                 A 
                 0.57 
                 9.9E−05 
                 5.6E−04 
               
               
                 rs7783337 
                 DGKB 
                 G 
                 1.27 
                 8.8E−05 
                 5.7E−04 
               
               
                 chr15:35201758 
                 MEIS2(+20.97 kb) 
                 T 
                 1.39 
                 8.8E−05 
                 6.4E−04 
               
               
                 chr1:85757359 
                 DDAH1(+53.95 kb)|CYR61(−61.69 kb) 
                 T 
                 0.70 
                 8.3E−05 
                 6.5E−04 
               
               
                 rs2491146 
                 SDC3(−13.09 kb)|PUM1(−75.13 
                 A 
                 0.82 
                 2.4E−05 
                 6.6E−04 
               
               
                   
                 kb)|MATN1(+132.3 kb)|LAPTM5(+98.56 kb) 
               
               
                 chr4:182189551 
                 ODZ3(−1293 kb) 
                 G 
                 1.74 
                 2.6E−06 
                 6.8E−04 
               
               
                 chr1:100166675 
                 AGL(+4.508 kb)|SLC35A3(−41.45 kb) 
                 T 
                 1.50 
                 1.8E−05 
                 7.0E−04 
               
               
                 rs11854658 
                 MFGE8(+54.89 kb)|HAPLN3(+72.78 kb)| 
                 G 
                 0.82 
                 3.9E−06 
                 7.6E−04 
               
               
                   
                 ACAN(+92.97 kb)|ABHD2(−119.9 kb) 
               
               
                 rs1912795 
                 B3GALTL(0) 
                 A 
                 1.19 
                 3.2E−05 
                 8.6E−04 
               
               
                 chr19:14775139 
                 OR7C1(+3.191 kb)|OR7A5(−23 kb) 
                 A 
                 0.71 
                 6.6E−05 
                 8.7E−04 
               
               
                 chr11:1768072 
                 CTSD(−231.9 kb) 
                 A 
                 0.75 
                 4.8E−06 
                 9.1E−04 
               
               
                 rs7958529 
                 ACVR1B, ACVRL1, bpl_41- 
                 G 
                 0.80 
                 5.5E−05 
                 9.5E−04 
               
               
                   
                 16, C12orf44, GRASP, KRT6A, KRT6B, KR 
               
               
                   
                 T6C, KRT7, KRT75, KRT80, KRT81, KRT8 
               
               
                   
                 2, KRT83, KRT84, KRT85, KRT86, NR4A1 
               
               
                 rs17071512 
                 NDFIP2(0) 
                 C 
                 0.71 
                 1.1E−05 
                 9.7E−04 
               
               
                 rs4260755 
                 HMGCLL1(0) 
                 A 
                 1.20 
                 7.5E−05 
                 9.8E−04 
               
               
                 rs2024393 
                 ZC3H7A(+30.67 kb)|TXNDC11(+70.43 kb) 
                 T 
                 1.53 
                 7.5E−05 
                 1.0E−03 
               
               
                   
                 |TNFRSF17(−151.9 
               
               
                   
                 kb)|SNN(+134.1 kb)|RUNDC2A(−163.5 
               
               
                   
                 kb)|RSL1D1(−20.98 kb)|GSPT1(−54.91 kb) 
               
               
                 rs12632671 
                 TKT 
                 A 
                 1.50 
                 5.7E−05 
                 1.1E−03 
               
               
                 rs13253938 
                 ZFAT(+315.9 kb)|KHDRBS3(−428.6 kb) 
                 G 
                 0.83 
                 3.0E−05 
                 1.1E−03 
               
               
                 rs343718 
                 TBX20(+335.4 kb)|SEPT7(−212 
                 A 
                 0.84 
                 5.7E−05 
                 1.1E−03 
               
               
                   
                 kb)|HERPUD2(−43.64 kb) 
               
               
                 rs1384044 
                 SGGZ(−276.3 kb)|DLC1(+298.6 kb) 
                 T 
                 0.84 
                 1.7E−05 
                 1.1E−03 
               
               
                 chr4:23188024 
                 PPARGC1A(−214.7 kb) 
                 A 
                 0.78 
                 5.3E−05 
                 1.2E−03 
               
               
                 rs722782 
                 MYOM2(−1494 kb) 
                 A 
                 0.76 
                 5.2E−05 
                 1.4E−03 
               
               
                 rs1737478 
                 CREG1 
                 T 
                 1.21 
                 8.5E−05 
                 1.4E−03 
               
               
                 rs5771717 
                 FAM19A5 
                 A 
                 1.36 
                 9.5E−06 
                 1.5E−03 
               
               
                 rs164700 
                 EFNA5(0) 
                 A 
                 1.27 
                 9.3E−05 
                 1.5E−03 
               
               
                 rs7623235 
                 DKFZp667G2110(0) 
                 A 
                 1.26 
                 5.2E−05 
                 1.6E−03 
               
               
                 rs6685751 
                 SPHAR(−384.2 kb)|RHOU(+173.5 kb)|RAB4A(−350.9 
                 A 
                 1.27 
                 6.0E−05 
                 1.7E−03 
               
               
                   
                 kb) 
               
               
                 rs1358395 
                 GRM3(−34.61 kb) 
                 A 
                 0.84 
                 9.4E−05 
                 1.7E−03 
               
               
                 chr10:88344492 
                 WAPAL(+72.97 kb)|OPN4(−59.8 kb) 
                 A 
                 1.29 
                 2.0E−05 
                 1.7E−03 
               
               
                 rs11183802 
                 FAM113B 
                 A 
                 1.45 
                 4.2E−06 
                 1.8E−03 
               
               
                 chr3:116361297 
                 ZBTB20(+12.48 kb) 
                 T 
                 0.73 
                 1.1E−05 
                 1.9E−03 
               
               
                 rs5015852 
                 ENPP3(0) 
                 T 
                 0.58 
                 6.5E−05 
                 2.2E−03 
               
               
                 rs10848645 
                 CACNA1C(0) 
                 G 
                 1.19 
                 9.4E−05 
                 2.2E−03 
               
               
                 chr10:56380194 
                 PCDH15(+149.1 kb) 
                 G 
                 1.68 
                 4.3E−05 
                 2.3E−03 
               
               
                 rs28621471 
                 MAPK10 
                 A 
                 0.76 
                 3.7E−05 
                 2.5E−03 
               
               
                 chr8:40099493 
                 INDO(+194.4 kb) 
                 T 
                 1.63 
                 8.9E−05 
                 2.7E−03 
               
               
                 rs16822447 
                 RAP2B(+65.39 kb) 
                 T 
                 0.78 
                 9.0E−05 
                 2.7E−03 
               
               
                 rs9291737 
                 FLJ37543(+74.42 kb) 
                 T 
                 0.84 
                 1.3E−05 
                 2.7E−03 
               
               
                 chr2:44132778 
                 PPM1B(−116.7 kb)|LRPPRC(+56.13 kb) 
                 G 
                 0.71 
                 5.5E−05 
                 2.9E−03 
               
               
                 rs2376241 
                 RELL1(−428.5 kb)|C4orf19(−291.6 kb) 
                 T 
                 1.20 
                 8.0E−05 
                 3.0E−03 
               
               
                 rs10225927 
                 VSTM2A(+132.5 kb)|SEC61G(−50.53 
                 G 
                 1.22 
                 9.1E−05 
                 3.1E−03 
               
               
                   
                 kb)|EGFR(−317.3 kb) 
               
               
                 rs8011890 
                 TCL1B 
                 A 
                 1.41 
                 2.3E−05 
                 3.1E−03 
               
               
                 rs6679773 
                 USH2A(+36.74 kb)|TGFB2(−1886 
                 T 
                 2.75 
                 5.3E−05 
                 3.4E−03 
               
               
                   
                 kb)|SPATA17(−1171 kb)|RRP15(−1825 
               
               
                   
                 kb)|PTPN14(+1909 kb)|KCTD3(+838.3 
               
               
                   
                 kb)|KCNK2(+1223 kb)|GPATCH2(−970.4 
               
               
                   
                 kb)|ESRRG(−43.11 
               
               
                   
                 kb)|CENPF(+1796 kb) 
               
               
                 rs13192030 
                 SESN1(0) 
                 T 
                 0.62 
                 7.8E−05 
                 3.4E−03 
               
               
                 chr11:104185708 
                 CASP4(−133.1 kb) 
                 T 
                 2.19 
                 2.7E−05 
                 4.2E−03 
               
               
                 rs1367068 
                 C4BPAL1, C4BPA, CD55 
                 G 
                 0.74 
                 5.6E−07 
                 4.5E−03 
               
               
                 rs1867348 
                 IGF2R(0) 
                 T 
                 1.34 
                 5.2E−05 
                 4.5E−03 
               
               
                 rs8076470 
                 SPATA20 
                 T 
                 1.21 
                 4.0E−06 
                 4.9E−03 
               
               
                 rs251525 
                 NDUFS4(−271 kb)|MOCS2(+179.9 
                 G 
                 1.19 
                 8.1E−05 
                 5.2E−03 
               
               
                   
                 kb)|ITGA2(+194.9 
               
               
                   
                 kb)|ITGA1(+336 kb)|FST(−191.1 kb) 
               
               
                 rs17408651 
                 ELTD1(+115.3 kb) 
                 T 
                 0.69 
                 7.5E−05 
                 5.5E−03 
               
               
                 rs1360751 
                 RREB1(0) 
                 A 
                 1.18 
                 7.4E−05 
                 6.0E−03 
               
               
                 chr5:165133520 
                 ODZ2(−1511 kb) 
                 C 
                 0.78 
                 1.0E−05 
                 6.1E−03 
               
               
                 rs8091635 
                 BRUNOL4(+711.5 kb) 
                 T 
                 1.25 
                 8.1E−06 
                 6.1E−03 
               
               
                 chr6:162467903 
                 PARK2(0) 
                 A 
                 0.76 
                 8.9E−05 
                 6.7E−03 
               
               
                 rs7260457 
                 LILRB3 
                 C 
                 0.61 
                 2.1E−05 
                 7.3E−03 
               
               
                 chr15:47957127 
                 ATP8B4(0) 
                 T 
                 0.67 
                 3.8E−05 
                 7.4E−03 
               
               
                 rs13094238 
                 MME(−18.73 kb) 
                 C 
                 0.68 
                 1.4E−05 
                 7.4E−03 
               
               
                 rs12798294 
                 PDGFD(0) 
                 C 
                 0.83 
                 3.5E−05 
                 8.0E−03 
               
               
                 rs9308649 
                 CNTNAP5(0) 
                 T 
                 0.81 
                 1.7E−05 
                 8.2E−03 
               
               
                 rs10503493 
                 SGCZ(0) 
                 A 
                 0.68 
                 6.8E−05 
                 8.2E−03 
               
               
                 rs9461856 
                 SYNGAP1(0) 
                 A 
                 0.85 
                 5.3E−05 
                 8.4E−03 
               
               
                 rs11592003 
                 KLF6(+127.8 kb) 
                 C 
                 0.79 
                 4.8E−05 
                 9.1E−03 
               
               
                 chr12:11233234 
                 TAS2R42(+2.424 kb) 
                 A 
                 1.29 
                 2.1E−05 
                 9.3E−03 
               
               
                 rs10768315 
                 RAG2(+1021 kb) 
                 T 
                 0.81 
                 2.0E−05 
                 1.0E−02 
               
               
                 rs2730613 
                 MRPS24 
                 C 
                 0.83 
                 1.5E−05 
                 1.2E−02 
               
               
                 rs10280782 
                 TRA2A, IGF2BP3, CLK2P 
                 G 
                 0.75 
                 2.6E−06 
                 1.3E−02 
               
               
                 rs7094579 
                 RPP30(−238.9 kb)|HTR7(−107.8 
                 T 
                 0.70 
                 8.4E−05 
                 1.3E−02 
               
               
                   
                 kb)|ANKRD1(−279 kb) 
               
               
                 chr5:26212150 
                 CDH9(−704.3 kb) 
                 C 
                 0.70 
                 3.9E−05 
                 1.4E−02 
               
               
                 rs2135548 
                 FOXP1(0) 
                 G 
                 1.20 
                 9.4E−05 
                 1.5E−02 
               
               
                 rs625761 
                 TMEM133(−218.2 kb)|PGR(−255.8 
                 G 
                 0.82 
                 9.7E−05 
                 1.5E−02 
               
               
                   
                 kb)∥CNTN5(+417.1 kb) 
               
               
                 rs1418473 
                 DAB1(−16.87 
                 A 
                 1.57 
                 3.0E−06 
                 1.6E−02 
               
               
                   
                 kb)|C8B(+15.02 kb)|C8A(+62.82 kb) 
               
               
                 rs2277252 
                 ARHGAP12(−98.91 kb) 
                 A 
                 1.23 
                 6.4E−06 
                 2.6E−02 
               
               
                 rs4073997 
                 NPLOC4(0) 
                 C 
                 1.26 
                 9.8E−05 
                 3.0E−02 
               
               
                 chr17:72483712 
                 MGAT5B(+25.65 kb) 
                 G 
                 0.63 
                 5.3E−05 
                 3.1E−02 
               
               
                 rs1492116 
                 AEBP2(+312 kb) 
                 C 
                 0.82 
                 6.4E−05 
                 3.4E−02 
               
               
                 rs9713311 
                 CDGAP(0) 
                 C 
                 1.18 
                 5.9E−05 
                 3.5E−02 
               
               
                 rs2127740 
                 PSMD7(−598.4 kb) 
                 A 
                 1.29 
                 3.3E−05 
                 3.9E−02 
               
               
                 chr6:119117772 
                 PLN(+129.5 kb)|MCM9(−155.7 
                 T 
                 0.71 
                 4.0E−05 
                 4.0E−02 
               
               
                   
                 kb)|ASF1A(−145.9 kb) 
               
               
                 rs1789110 
                 MBP 
                 C 
                 1.22 
                 2.3E−06 
                 4.7E−02 
               
               
                 chr16:17310751 
                 XYLT1(0) 
                 G 
                 0.72 
                 2.7E−05 
                 4.7E−02 
               
               
                 rs235195 
                 TUBB1(−48.54 kb)|TH1L(−10.54 
                 A 
                 1.37 
                 5.1E−05 
                 7.5E−02 
               
               
                   
                 kb)|STX16(+291.2 kb)|SLMO2(−62.43 
               
               
                   
                 kb)|NPEPL1(+254.9 kb)|GNAS(+59.52 
               
               
                   
                 kb)|CTSZ(−24.47 kb)|ATP5E(−57.97 kb) 
               
               
                 rs11596472 
                 ARL5B(+385.1 kb) 
                 G 
                 1.42 
                 6.1E−06 
                 8.7E−02 
               
               
                 rs12926103 
                 FOXF1(−172.4 kb) 
                 A 
                 1.41 
                 2.7E−05 
                 1.5E−01 
               
               
                 rs17155281 
                 HIBADH(−56.23 kb) 
                 C 
                 0.79 
                 3.3E−05 
                 1.9E−01 
               
               
                 rs135912 
                 PRR5(−270.7 kb)|PARVB(+276.2 kb)|PARVG(+238.7 
                 G 
                 0.77 
                 9.1E−05 
                 2.2E−01 
               
               
                   
                 kb)|LDOC1L(−94.52 
               
               
                   
                 kb)|KIAA1644(+132.5 kb) 
               
               
                 chr3:126793536 
                 OSBPL11(0) 
                 C 
                 0.53 
                 9.6E−05 
                 2.7E−01 
               
               
                 rs16971055 
                 TNRC6C(+225.5 kb)|TMC8(+187.5 kb)|T 
                 A 
                 1.55 
                 2.8E−05 
                 2.9E−01 
               
               
                   
                 MC6(+198.1 kb)|TK1(+143.3 kb)|SYNGR 
               
               
                   
                 2(+157.5 kb)|SOCS3(−26.32 kb)|PGS1(−48.19 
               
               
                   
                 kb)|BIRC5(+104.8 kb)|AFMID(+122.8 kb) 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 4 
               
               
                   
               
             
             
               
                 IMP 
                 SNP 
                 CHR:BP 
                 A1 
                 A2 
                 FRQ_1 
                 FRQ_45 
                 FRQ_4 
                 FRQ_5 
                 P_1vs45 
               
               
                   
               
               
                 1KG 
                 rs1367068 
                 1:205461564 
                 A 
                 G 
                 0.7715 
                 0.8076 
                 0.8035 
                 0.8101 
                 5.60E−07 
               
               
                 1KG 
                 rs1443179 
                 4:128495772 
                 T 
                 G 
                 0.0587 
                 0.077 
                 0.0856 
                 0.0732 
                 1.44E−06 
               
               
                 1KG 
                 rs9328048 
                 6:1324870 
                 T 
                 C 
                 0.3985 
                 0.3608 
                 0.3645 
                 0.3591 
                 2.26E−06 
               
               
                 1KG 
                 chr4: 182189551 
                 4:182189551 
                 A 
                 G 
                 0.894 
                 0.8848 
                 0.8894 
                 0.882 
                 2.58E−06 
               
               
                 1KG 
                 rs1915098 
                 3:119681130 
                 A 
                 G 
                 0.2202 
                 0.1857 
                 0.1744 
                 0.192 
                 2.74E−06 
               
               
                 1KG 
                 rs1418473 
                 1:57219300 
                 A 
                 G 
                 0.0511 
                 0.0785 
                 0.0873 
                 0.074 
                 3.03E−06 
               
               
                 1KG 
                 rs11183802 
                 12:45893566 
                 A 
                 G 
                 0.0929 
                 0.1221 
                 0.1099 
                 0.1276 
                 4.17E−06 
               
               
                 1KG 
                 rs728371 
                 6:132523980 
                 A 
                 G 
                 0.3117 
                 0.3509 
                 0.3601 
                 0.3469 
                 4.69E−06 
               
               
                 1KG 
                 chr11: 1768072 
                 11:1768072 
                 A 
                 G 
                 0.1756 
                 0.1443 
                 0.1485 
                 0.1425 
                 4.81E−06 
               
               
                 1KG 
                 rs11596472 
                 10:19392088 
                 A 
                 G 
                 0.8158 
                 0.7885 
                 0.778 
                 0.7939 
                 6.06E−06 
               
               
                 1KG 
                 rs6982567 
                 8:96819457 
                 T 
                 C 
                 0.1321 
                 0.1714 
                 0.1582 
                 0.1778 
                 6.14E−06 
               
               
                 1KG 
                 rs2277252 
                 10:32036318 
                 A 
                 G 
                 0.4581 
                 0.4968 
                 0.4978 
                 0.4974 
                 6.45E−06 
               
               
                 1KG 
                 rs8091635 
                 18:34111545 
                 T 
                 C 
                 0.3605 
                 0.4065 
                 0.3814 
                 0.4189 
                 8.08E−06 
               
               
                 1KG 
                 rs9366769 
                 6:31277268 
                 T 
                 C 
                 0.7696 
                 0.8052 
                 0.81 
                 0.8026 
                 9.42E−06 
               
               
                 1KG 
                 rs5771717 
                 22:47467676 
                 A 
                 G 
                 0.0904 
                 0.1136 
                 0.1473 
                 0.0989 
                 9.52E−06 
               
               
                 1KG 
                 chr22: 33891064 
                 22:33891064 
                 T 
                 C 
                 0.0767 
                 0.0618 
                 0.0651 
                 0.0602 
                 9.91E−06 
               
               
                 1KG 
                 chr5: 165133520 
                 5:165133520 
                 T 
                 C 
                 0.8074 
                 0.8402 
                 0.8363 
                 0.8429 
                 1.02E−05 
               
               
                 1KG 
                 chr3: 116361297 
                 3:116361297 
                 T 
                 C 
                 0.197 
                 0.1745 
                 0.1779 
                 0.1734 
                 1.07E−05 
               
               
                 1KG 
                 rs17071512 
                 13:78960018 
                 T 
                 C 
                 0.877 
                 0.8999 
                 0.8931 
                 0.9027 
                 1.08E−05 
               
               
                 1KG 
                 rs1384044 
                 8:13715406 
                 T 
                 C 
                 0.53 
                 0.4926 
                 0.4865 
                 0.4962 
                 1.66E−05 
               
               
                 1KG 
                 rs9308649 
                 2:124751486 
                 A 
                 T 
                 0.7856 
                 0.8183 
                 0.827 
                 0.8143 
                 1.71E−05 
               
               
                 1KG 
                 rs10067691 
                 5:64292165 
                 A 
                 G 
                 0.1102 
                 0.0917 
                 0.095 
                 0.0897 
                 1.72E−05 
               
               
                 1KG 
                 chr1: 100166675 
                 1:100166675 
                 T 
                 C 
                 0.0469 
                 0.061 
                 0.0666 
                 0.0585 
                 1.81E−05 
               
               
                 1KG 
                 rs10768315 
                 11:37597461 
                 T 
                 C 
                 0.2262 
                 0.2126 
                 0.2041 
                 0.2166 
                 2.00E−05 
               
               
                 1KG 
                 chr10: 88344492 
                 10:88344492 
                 A 
                 C 
                 0.1391 
                 0.163 
                 0.1577 
                 0.1659 
                 2.03E−05 
               
               
                 1KG 
                 rs7260457 
                 19:59425996 
                 C 
                 G 
                 0.2151 
                 0.1969 
                 0.1929 
                 0.1986 
                 2.07E−05 
               
               
                 1KG 
                 chr12: 11233234 
                 12:11233234 
                 A 
                 T 
                 0.2622 
                 0.2941 
                 0.2924 
                 0.2934 
                 2.14E−05 
               
               
                 1KG 
                 rs2491146 
                 1:31101812 
                 A 
                 G 
                 0.4538 
                 0.4187 
                 0.4062 
                 0.4238 
                 2.38E−05 
               
               
                 1KG 
                 chr16: 17310751 
                 16:17310751 
                 A 
                 G 
                 0.8922 
                 0.9123 
                 0.9132 
                 0.9114 
                 2.66E−05 
               
               
                 1KG 
                 rs4711751 
                 6:43936560 
                 T 
                 C 
                 0.5164 
                 0.5475 
                 0.5531 
                 0.5445 
                 2.66E−05 
               
               
                 1KG 
                 chr11: 104185708 
                 11:104185708 
                 T 
                 G 
                 0.0696 
                 0.076 
                 0.076 
                 0.0762 
                 2.75E−05 
               
               
                 1KG 
                 rs1851808 
                 2:76232489 
                 A 
                 G 
                 0.6391 
                 0.5946 
                 0.601 
                 0.5908 
                 2.75E−05 
               
               
                 1KG 
                 rs13253938 
                 8:136110326 
                 A 
                 G 
                 0.4529 
                 0.5041 
                 0.5015 
                 0.5043 
                 2.96E−05 
               
               
                 1KG 
                 rs529478 
                 18:53934507 
                 A 
                 T 
                 0.4692 
                 0.5086 
                 0.5017 
                 0.5109 
                 3.33E−05 
               
               
                 1KG 
                 rs12798294 
                 11:103362906 
                 C 
                 G 
                 0.3164 
                 0.2803 
                 0.2821 
                 0.2803 
                 3.46E−05 
               
               
                 1KG 
                 chr8: 123521912 
                 8:123521912 
                 A 
                 G 
                 0.0874 
                 0.1017 
                 0.0967 
                 0.1036 
                 3.59E−05 
               
               
                 1KG 
                 rs28621471 
                 4:86877248 
                 A 
                 G 
                 0.3046 
                 0.2786 
                 0.2856 
                 0.2751 
                 3.73E−05 
               
               
                 1KG 
                 chr15: 47957127 
                 15:47957127 
                 T 
                 G 
                 0.097 
                 0.0757 
                 0.0702 
                 0.0778 
                 3.80E−05 
               
               
                 1KG 
                 chr5: 26212150 
                 5:26212150 
                 T 
                 C 
                 0.9194 
                 0.9394 
                 0.9405 
                 0.9384 
                 3.92E−05 
               
               
                 1KG 
                 chr2: 180796214 
                 2:180796214 
                 A 
                 C 
                 0.2095 
                 0.1777 
                 0.1783 
                 0.177 
                 3.93E−05 
               
               
                 1KG 
                 rs4967980 
                 16:23091095 
                 T 
                 C 
                 0.7845 
                 0.7499 
                 0.7452 
                 0.7526 
                 3.93E−05 
               
               
                 1KG 
                 chr6: 119117772 
                 6:119117772 
                 T 
                 C 
                 0.1086 
                 0.0892 
                 0.0797 
                 0.0932 
                 4.04E−05 
               
               
                 1KG 
                 rs12520598 
                 5:74385314 
                 T 
                 C 
                 0.1107 
                 0.092 
                 0.0856 
                 0.0953 
                 4.22E−05 
               
               
                 1KG 
                 chr10: 56380194 
                 10:56380194 
                 A 
                 G 
                 0.898 
                 0.8876 
                 0.8849 
                 0.8888 
                 4.33E−05 
               
               
                 1KG 
                 chr12: 8919954 
                 12:8919954 
                 A 
                 T 
                 0.9248 
                 0.9348 
                 0.9326 
                 0.9358 
                 4.66E−05 
               
               
                 1KG 
                 rs11592003 
                 10:3945290 
                 T 
                 C 
                 0.8209 
                 0.85 
                 0.8582 
                 0.846 
                 4.79E−05 
               
               
                 1KG 
                 rs235195 
                 20:56979160 
                 A 
                 G 
                 0.1339 
                 0.1479 
                 0.1444 
                 0.15 
                 5.07E−05 
               
               
                 1KG 
                 rs7623235 
                 3:99135842 
                 A 
                 T 
                 0.201 
                 0.2268 
                 0.2143 
                 0.2319 
                 5.19E−05 
               
               
                 1KG 
                 chr4: 23188024 
                 4:23188024 
                 A 
                 T 
                 0.1683 
                 0.1431 
                 0.1447 
                 0.141 
                 5.26E−05 
               
               
                 1KG 
                 rs12908430 
                 15:40375218 
                 A 
                 G 
                 0.162 
                 0.1442 
                 0.1401 
                 0.1456 
                 5.29E−05 
               
               
                 1KG 
                 chr17: 72483712 
                 17:72483712 
                 A 
                 G 
                 0.9281 
                 0.939 
                 0.9384 
                 0.9389 
                 5.30E−05 
               
               
                 1KG 
                 rs6679773 
                 1:214700097 
                 T 
                 C 
                 0.0688 
                 0.0766 
                 0.0787 
                 0.0756 
                 5.30E−05 
               
               
                 1KG 
                 chr1: 163986967 
                 1:163986967 
                 T 
                 C 
                 0.066 
                 0.0553 
                 0.0503 
                 0.0575 
                 5.42E−05 
               
               
                 1KG 
                 rs7958529 
                 12:50881293 
                 C 
                 G 
                 0.7298 
                 0.7572 
                 0.7584 
                 0.7575 
                 5.45E−05 
               
               
                 1KG 
                 chr2: 44132778 
                 2:44132778 
                 A 
                 G 
                 0.865 
                 0.8855 
                 0.8887 
                 0.8844 
                 5.50E−05 
               
               
                 1KG 
                 chr5: 113645446 
                 5:113645446 
                 C 
                 G 
                 0.8718 
                 0.8494 
                 0.8425 
                 0.8529 
                 5.54E−05 
               
               
                 1KG 
                 rs11067403 
                 12:114010367 
                 T 
                 C 
                 0.6488 
                 0.6846 
                 0.6629 
                 0.6935 
                 5.65E−05 
               
               
                 1KG 
                 rs343718 
                 7:35595154 
                 A 
                 C 
                 0.4303 
                 0.3598 
                 0.3814 
                 0.3503 
                 5.71E−05 
               
               
                 1KG 
                 rs6685751 
                 1:227122574 
                 A 
                 C 
                 0.4817 
                 0.5145 
                 0.5116 
                 0.5159 
                 6.00E−05 
               
               
                 1KG 
                 rs1492116 
                 12:19878442 
                 T 
                 C 
                 0.7597 
                 0.7886 
                 0.7765 
                 0.7942 
                 6.45E−05 
               
               
                 1KG 
                 rs5015852 
                 6:132002096 
                 A 
                 T 
                 0.8648 
                 0.8791 
                 0.8809 
                 0.8781 
                 6.50E−05 
               
               
                 1KG 
                 chr19: 14775139 
                 19:14775139 
                 A 
                 G 
                 0.1123 
                 0.0947 
                 0.0935 
                 0.0949 
                 6.58E−05 
               
               
                 1KG 
                 chr11: 124212812 
                 11:124212812 
                 T 
                 C 
                 0.0946 
                 0.106 
                 0.1074 
                 0.1056 
                 6.67E−05 
               
               
                 1KG 
                 rs10503493 
                 8:14247492 
                 A 
                 C 
                 0.0583 
                 0.0416 
                 0.0377 
                 0.0439 
                 6.78E−05 
               
               
                 1KG 
                 chr4: 86206508 
                 4:86206508 
                 T 
                 C 
                 0.0806 
                 0.0669 
                 0.0578 
                 0.071 
                 6.94E−05 
               
               
                 1KG 
                 rs2883171 
                 5:21309600 
                 T 
                 G 
                 0.8852 
                 0.8609 
                 0.8625 
                 0.8605 
                 7.25E−05 
               
               
                 1KG 
                 rs1360751 
                 6:7152544 
                 A 
                 C 
                 0.5214 
                 0.5563 
                 0.5644 
                 0.5526 
                 7.38E−05 
               
               
                 1KG 
                 rs2024393 
                 16:11814579 
                 T 
                 C 
                 0.1323 
                 0.1506 
                 0.1556 
                 0.1482 
                 7.45E−05 
               
               
                 1KG 
                 rs4260755 
                 6:55456674 
                 A 
                 C 
                 0.3446 
                 0.3881 
                 0.3802 
                 0.3905 
                 7.49E−05 
               
               
                 1KG 
                 rs17408651 
                 1:79360392 
                 T 
                 G 
                 0.1211 
                 0.1057 
                 0.1072 
                 0.1044 
                 7.50E−05 
               
               
                 1KG 
                 rs13192030 
                 6:109470664 
                 A 
                 T 
                 0.8935 
                 0.9066 
                 0.9076 
                 0.9058 
                 7.84E−05 
               
               
                 1KG 
                 rs12632105 
                 3:130591125 
                 C 
                 G 
                 0.165 
                 0.1818 
                 0.2174 
                 0.1663 
                 8.06E−05 
               
               
                 1KG 
                 chr1: 85757359 
                 1:85757359 
                 T 
                 C 
                 0.1217 
                 0.1063 
                 0.1025 
                 0.1082 
                 8.26E−05 
               
               
                 1KG 
                 chr10: 57479107 
                 10:57479107 
                 A 
                 C 
                 0.0961 
                 0.1202 
                 0.1232 
                 0.1194 
                 8.31E−05 
               
               
                 1KG 
                 rs7094579 
                 10:92382787 
                 T 
                 C 
                 0.064 
                 0.045 
                 0.0467 
                 0.0446 
                 8.38E−05 
               
               
                 1KG 
                 chr15: 35201758 
                 15:35201758 
                 T 
                 G 
                 0.1305 
                 0.1462 
                 0.1421 
                 0.1479 
                 8.75E−05 
               
               
                 1KG 
                 chr6: 162467903 
                 6:162467903 
                 A 
                 G 
                 0.1204 
                 0.0945 
                 0.1012 
                 0.092 
                 8.90E−05 
               
               
                 1KG 
                 chr8: 40099493 
                 8:40099493 
                 A 
                 T 
                 0.9144 
                 0.9013 
                 0.9023 
                 0.9012 
                 8.92E−05 
               
               
                 1KG 
                 rs16822447 
                 3:154434339 
                 A 
                 T 
                 0.8267 
                 0.8484 
                 0.8354 
                 0.8546 
                 9.03E−05 
               
               
                 1KG 
                 rs135912 
                 22:43172593 
                 A 
                 G 
                 0.828 
                 0.8533 
                 0.851 
                 0.8544 
                 9.13E−05 
               
               
                 1KG 
                 chr5: 149749881 
                 5:149749881 
                 C 
                 G 
                 0.0572 
                 0.0765 
                 0.0778 
                 0.0755 
                 9.18E−05 
               
               
                 1KG 
                 rs2135548 
                 3:71584585 
                 A 
                 G 
                 0.7682 
                 0.7325 
                 0.729 
                 0.7345 
                 9.36E−05 
               
               
                 1KG 
                 rs1358395 
                 7:86076557 
                 A 
                 G 
                 0.3321 
                 0.3001 
                 0.2996 
                 0.3008 
                 9.41E−05 
               
               
                 1KG 
                 chr3: 126793536 
                 3:126793536 
                 A 
                 C 
                 0.9216 
                 0.9328 
                 0.934 
                 0.9324 
                 9.64E−05 
               
               
                 1KG 
                 rs625761 
                 11:100149779 
                 A 
                 G 
                 0.7544 
                 0.7843 
                 0.8014 
                 0.7773 
                 9.68E−05 
               
               
                 1KG 
                 rs1540819 
                 3:118210505 
                 T 
                 C 
                 0.4972 
                 0.5379 
                 0.518 
                 0.546 
                 9.74E−05 
               
               
                 1KG 
                 rs4073997 
                 17:77136846 
                 C 
                 G 
                 0.2583 
                 0.2845 
                 0.2673 
                 0.2923 
                 9.79E−05 
               
               
                 1KG 
                 chr1: 59476907 
                 1:59476907 
                 A 
                 G 
                 0.0974 
                 0.0879 
                 0.0854 
                 0.0891 
                 9.88E−05 
               
               
                 HM3 
                 rs16965939 
                 15:35992085 
                 T 
                 C 
                 0.1076 
                 0.085 
                 0.0803 
                 0.0862 
                 1.11E−06 
               
               
                 HM3 
                 rs1999930 
                 6:116493827 
                 T 
                 C 
                 0.3083 
                 0.261 
                 0.2599 
                 0.261 
                 2.22E−06 
               
               
                 HM3 
                 rs1789110 
                 18:72988032 
                 A 
                 C 
                 0.6301 
                 0.5853 
                 0.5554 
                 0.5993 
                 2.35E−06 
               
               
                 HM3 
                 rs10280782 
                 7:23550807 
                 A 
                 G 
                 0.8464 
                 0.8778 
                 0.8639 
                 0.8833 
                 2.61E−06 
               
               
                 HM3 
                 rs1079982 
                 22:36259705 
                 T 
                 G 
                 0.0699 
                 0.046 
                 0.0433 
                 0.0473 
                 3.01E−06 
               
               
                 HM3 
                 rs11854658 
                 15:87312556 
                 A 
                 G 
                 0.636 
                 0.6783 
                 0.6726 
                 0.6794 
                 3.87E−06 
               
               
                 HM3 
                 rs8076470 
                 17:45980827 
                 T 
                 C 
                 0.3673 
                 0.404 
                 0.4037 
                 0.4043 
                 3.98E−06 
               
               
                 HM3 
                 rs8053796 
                 16:74921678 
                 T 
                 C 
                 0.2393 
                 0.2701 
                 0.2808 
                 0.2653 
                 4.39E−06 
               
               
                 HM3 
                 rs2037156 
                 6:93573222 
                 A 
                 G 
                 0.8273 
                 0.7909 
                 0.7932 
                 0.7901 
                 7.94E−06 
               
               
                 HM3 
                 rs3760775 
                 19:5792356 
                 T 
                 G 
                 0.0675 
                 0.0485 
                 0.0463 
                 0.0498 
                 1.27E−05 
               
               
                 HM3 
                 rs9291737 
                 5:61112540 
                 A 
                 T 
                 0.5787 
                 0.6184 
                 0.6177 
                 0.6213 
                 1.30E−05 
               
               
                 HM3 
                 rs13094238 
                 3:156261403 
                 T 
                 C 
                 0.8449 
                 0.8656 
                 0.8752 
                 0.8612 
                 1.36E−05 
               
               
                 HM3 
                 rs2730613 
                 7:43880667 
                 A 
                 C 
                 0.6269 
                 0.6643 
                 0.6733 
                 0.6613 
                 1.47E−05 
               
               
                 HM3 
                 rs10103808 
                 8:139212254 
                 A 
                 T 
                 0.9102 
                 0.8883 
                 0.8914 
                 0.8876 
                 1.92E−05 
               
               
                 HM3 
                 rs7720497 
                 5:5291813 
                 C 
                 G 
                 0.9484 
                 0.9279 
                 0.9277 
                 0.9281 
                 2.05E−05 
               
               
                 HM3 
                 rs6531212 
                 2:20201501 
                 T 
                 C 
                 0.3554 
                 0.3169 
                 0.3261 
                 0.3121 
                 2.13E−05 
               
               
                 HM3 
                 rs8011890 
                 14:95216646 
                 A 
                 C 
                 0.0797 
                 0.1028 
                 0.1059 
                 0.1007 
                 2.34E−05 
               
               
                 HM3 
                 rs12926103 
                 16:84929276 
                 A 
                 G 
                 0.0569 
                 0.0764 
                 0.0767 
                 0.0775 
                 2.67E−05 
               
               
                 HM3 
                 rs16971055 
                 17:73838135 
                 A 
                 G 
                 0.0849 
                 0.0976 
                 0.1005 
                 0.0965 
                 2.83E−05 
               
               
                 HM3 
                 rs1912795 
                 13:30736688 
                 A 
                 G 
                 0.4275 
                 0.4639 
                 0.4618 
                 0.4659 
                 3.21E−05 
               
               
                 HM3 
                 rs2127740 
                 16:72289810 
                 A 
                 G 
                 0.1145 
                 0.1393 
                 0.1393 
                 0.1383 
                 3.30E−05 
               
               
                 HM3 
                 rs17155281 
                 7:27475356 
                 T 
                 C 
                 0.69 
                 0.719 
                 0.7299 
                 0.7141 
                 3.34E−05 
               
               
                 HM3 
                 rs4256145 
                 3:163192835 
                 A 
                 G 
                 0.6505 
                 0.694 
                 0.702 
                 0.6903 
                 3.62E−05 
               
               
                 HM3 
                 rs6587759 
                 1:247130153 
                 A 
                 G 
                 0.0579 
                 0.0711 
                 0.066 
                 0.0736 
                 4.17E−05 
               
               
                 HM3 
                 rs2052572 
                 19:36639376 
                 A 
                 G 
                 0.3041 
                 0.3451 
                 0.3493 
                 0.3435 
                 4.43E−05 
               
               
                 HM3 
                 rs13278062 
                 8:23138916 
                 T 
                 G 
                 0.5113 
                 0.5457 
                 0.5218 
                 0.5569 
                 5.01E−05 
               
               
                 HM3 
                 rs722782 
                 8:506479 
                 A 
                 C 
                 0.1081 
                 0.0836 
                 0.065 
                 0.0915 
                 5.22E−05 
               
               
                 HM3 
                 rs1867348 
                 6:160376153 
                 T 
                 C 
                 0.0723 
                 0.0979 
                 0.1091 
                 0.0934 
                 5.23E−05 
               
               
                 HM3 
                 rs9461856 
                 6:33503177 
                 A 
                 G 
                 0.5248 
                 0.4881 
                 0.478 
                 0.4934 
                 5.32E−05 
               
               
                 HM3 
                 rs2270637 
                 8:20081107 
                 C 
                 G 
                 0.8007 
                 0.8279 
                 0.8311 
                 0.8271 
                 5.44E−05 
               
               
                 HM3 
                 rs2798832 
                 10:8226099 
                 T 
                 C 
                 0.2312 
                 0.2625 
                 0.2636 
                 0.2613 
                 5.54E−05 
               
               
                 HM3 
                 rs12632671 
                 3:53233464 
                 A 
                 G 
                 0.0413 
                 0.0583 
                 0.044 
                 0.0636 
                 5.73E−05 
               
               
                 HM3 
                 rs9713311 
                 3:120558458 
                 T 
                 C 
                 0.6302 
                 0.5938 
                 0.5841 
                 0.5983 
                 5.87E−05 
               
               
                 HM3 
                 rs7626245 
                 3:101053451 
                 C 
                 G 
                 0.0642 
                 0.0869 
                 0.0884 
                 0.0869 
                 6.63E−05 
               
               
                 HM3 
                 rs513683 
                 11:73662041 
                 C 
                 G 
                 0.4594 
                 0.4218 
                 0.4183 
                 0.4237 
                 7.56E−05 
               
               
                 HM3 
                 rs2376241 
                 4:36840346 
                 T 
                 G 
                 0.2416 
                 0.2741 
                 0.2854 
                 0.2706 
                 7.95E−05 
               
               
                 HM3 
                 rs251525 
                 5:52621268 
                 A 
                 G 
                 0.6907 
                 0.6564 
                 0.6454 
                 0.6633 
                 8.06E−05 
               
               
                 HM3 
                 rs1737478 
                 1:165795961 
                 T 
                 C 
                 0.2189 
                 0.2486 
                 0.2452 
                 0.2501 
                 8.47E−05 
               
               
                 HM3 
                 rs7783337 
                 7:14123511 
                 A 
                 G 
                 0.8694 
                 0.8452 
                 0.8345 
                 0.8501 
                 8.84E−05 
               
               
                 HM3 
                 rs10225927 
                 7:54736904 
                 A 
                 G 
                 0.8098 
                 0.7807 
                 0.7796 
                 0.7809 
                 9.06E−05 
               
               
                 HM3 
                 rs164700 
                 5:106936632 
                 A 
                 C 
                 0.1396 
                 0.1709 
                 0.1727 
                 0.1696 
                 9.26E−05 
               
               
                 HM3 
                 rs10848645 
                 12:2290505 
                 A 
                 G 
                 0.5848 
                 0.5515 
                 0.5417 
                 0.5561 
                 9.39E−05 
               
               
                   
               
             
          
           
               
                 IMP 
                 SNP 
                 P_1vs5 
                 P_1vs4 
                 P_4vs5 
                 OR_1vs45 
                 OR_1vs5 
                 OR_1vs4 
               
               
                   
               
               
                 1KG 
                 rs1367068 
                 2.18E−06 
                 0.001938 
                 0.6018 
                 1.3457 
                 1.3741 
                 1.3071 
               
               
                 1KG 
                 rs1443179 
                 0.0004505 
                 1.73E−06 
                 0.1242 
                 1.6593 
                 1.5105 
                 1.9613 
               
               
                 1KG 
                 rs9328048 
                 1.12E−05 
                 0.002746 
                 0.7665 
                 0.7763 
                 0.7699 
                 0.7915 
               
               
                 1KG 
                 chr4: 182189551 
                 3.87E−07 
                 0.04747 
                 0.03589 
                 0.5758 
                 0.5205 
                 0.7122 
               
               
                 1KG 
                 rs1915098 
                 0.0004493 
                 5.65E−05 
                 0.1709 
                 0.7849 
                 0.8175 
                 0.7324 
               
               
                 1KG 
                 rs1418473 
                 0.002335 
                 2.07E−07 
                 0.02957 
                 1.5676 
                 1.3911 
                 1.9294 
               
               
                 1KG 
                 rs11183802 
                 6.17E−07 
                 0.05563 
                 0.116 
                 1.4459 
                 1.5481 
                 1.2508 
               
               
                 1KG 
                 rs728371 
                 8.69E−05 
                 0.0003392 
                 0.4542 
                 1.2293 
                 1.2178 
                 1.2604 
               
               
                 1KG 
                 chr11: 1768072 
                 2.80E−05 
                 0.005699 
                 0.6279 
                 0.7511 
                 0.7449 
                 0.7758 
               
               
                 1KG 
                 rs11596472 
                 0.0007817 
                 4.20E−06 
                 0.03616 
                 0.7061 
                 0.7516 
                 0.6049 
               
               
                 1KG 
                 rs6982567 
                 4.59E−06 
                 0.008215 
                 0.4558 
                 1.3214 
                 1.3598 
                 1.2698 
               
               
                 1KG 
                 rs2277252 
                 4.35E−05 
                 0.001441 
                 0.9691 
                 1.2345 
                 1.2354 
                 1.239 
               
               
                 1KG 
                 rs8091635 
                 1.81E−07 
                 0.2065 
                 0.009328 
                 1.2464 
                 1.3295 
                 1.0944 
               
               
                 1KG 
                 rs9366769 
                 0.0002831 
                 0.0004622 
                 0.3999 
                 1.2501 
                 1.2274 
                 1.2983 
               
               
                 1KG 
                 rs5771717 
                 0.08595 
                 3.48E−11 
                 7.10E−07 
                 1.3632 
                 1.1502 
                 1.8242 
               
               
                 1KG 
                 chr22: 33891064 
                 3.12E−05 
                 0.0119 
                 0.4455 
                 0.5118 
                 0.4814 
                 0.5707 
               
               
                 1KG 
                 chr5: 165133520 
                 4.59E−05 
                 0.004485 
                 0.6401 
                 1.2744 
                 1.2886 
                 1.257 
               
               
                 1KG 
                 chr3: 116361297 
                 1.99E−05 
                 0.0154 
                 0.5013 
                 0.7342 
                 0.7127 
                 0.7793 
               
               
                 1KG 
                 rs17071512 
                 5.38E−06 
                 0.04102 
                 0.22 
                 1.4055 
                 1.4971 
                 1.2542 
               
               
                 1KG 
                 rs1384044 
                 0.0003344 
                 0.001241 
                 0.7053 
                 0.8377 
                 0.8481 
                 0.8247 
               
               
                 1KG 
                 rs9308649 
                 0.0008531 
                 0.00026 
                 0.3382 
                 1.2416 
                 1.2059 
                 1.3153 
               
               
                 1KG 
                 rs10067691 
                 2.20E−05 
                 0.01173 
                 0.49 
                 0.6712 
                 0.6389 
                 0.7115 
               
               
                 1KG 
                 chr1: 100166675 
                 0.0002956 
                 0.0004285 
                 0.4504 
                 1.4999 
                 1.4689 
                 1.5723 
               
               
                 1KG 
                 rs10768315 
                 0.0004323 
                 0.003677 
                 0.9683 
                 0.8058 
                 0.8205 
                 0.8053 
               
               
                 1KG 
                 chr10: 88344492 
                 2.88E−05 
                 0.01875 
                 0.3949 
                 1.2872 
                 1.3154 
                 1.2204 
               
               
                 1KG 
                 rs7260457 
                 0.00104 
                 0.0002468 
                 0.2306 
                 0.6139 
                 0.6586 
                 0.5268 
               
               
                 1KG 
                 chr12: 11233234 
                 0.0001776 
                 0.002787 
                 0.7035 
                 1.2854 
                 1.2752 
                 1.2883 
               
               
                 1KG 
                 rs2491146 
                 0.001371 
                 0.0002038 
                 0.2376 
                 0.8228 
                 0.8478 
                 0.7798 
               
               
                 1KG 
                 chr16: 17310751 
                 0.0002343 
                 0.004891 
                 0.8523 
                 1.392 
                 1.3852 
                 1.3891 
               
               
                 1KG 
                 rs4711751 
                 0.0007193 
                 0.0006112 
                 0.6538 
                 1.2192 
                 1.1931 
                 1.2684 
               
               
                 1KG 
                 chr11: 104185708 
                 0.0001158 
                 0.007171 
                 0.7311 
                 2.1902 
                 2.2292 
                 2.054 
               
               
                 1KG 
                 rs1851808 
                 6.83E−05 
                 0.01279 
                 0.4495 
                 0.8368 
                 0.8272 
                 0.8593 
               
               
                 1KG 
                 rs13253938 
                 0.0002487 
                 0.003161 
                 0.8557 
                 1.2071 
                 1.2036 
                 1.2116 
               
               
                 1KG 
                 rs529478 
                 0.0001374 
                 0.01656 
                 0.4809 
                 1.2104 
                 1.2154 
                 1.1726 
               
               
                 1KG 
                 rs12798294 
                 0.0002762 
                 0.00827 
                 0.8248 
                 0.825 
                 0.8273 
                 0.8369 
               
               
                 1KG 
                 chr8: 123521912 
                 4.13E−05 
                 0.04697 
                 0.1884 
                 1.7769 
                 1.8751 
                 1.4959 
               
               
                 1KG 
                 rs28621471 
                 1.86E−05 
                 0.0351 
                 0.3624 
                 0.7613 
                 0.7297 
                 0.8166 
               
               
                 1KG 
                 chr15: 47957127 
                 0.001928 
                 0.0001134 
                 0.1374 
                 0.6679 
                 0.7123 
                 0.5535 
               
               
                 1KG 
                 chr5: 26212150 
                 0.0001975 
                 0.0042 
                 0.8515 
                 1.4249 
                 1.4366 
                 1.4542 
               
               
                 1KG 
                 chr2: 180796214 
                 0.0001339 
                 0.006444 
                 0.9313 
                 0.808 
                 0.7997 
                 0.8129 
               
               
                 1KG 
                 rs4967980 
                 0.0005012 
                 0.001415 
                 0.5372 
                 0.815 
                 0.825 
                 0.7971 
               
               
                 1KG 
                 chr6: 119117772 
                 0.005895 
                 4.55E−05 
                 0.0698 
                 0.7144 
                 0.7789 
                 0.5954 
               
               
                 1KG 
                 rs12520598 
                 0.001511 
                 0.0006204 
                 0.1961 
                 0.7033 
                 0.7367 
                 0.637 
               
               
                 1KG 
                 chr10: 56380194 
                 0.0007999 
                 0.001293 
                 0.6541 
                 0.5967 
                 0.6266 
                 0.5643 
               
               
                 1KG 
                 chr12: 8919954 
                 7.18E−05 
                 0.03968 
                 0.3457 
                 2.0839 
                 2.2434 
                 1.7108 
               
               
                 1KG 
                 rs11592003 
                 0.001862 
                 0.0004429 
                 0.2299 
                 1.2621 
                 1.2195 
                 1.3556 
               
               
                 1KG 
                 rs235195 
                 1.40E−05 
                 0.05916 
                 0.2021 
                 1.369 
                 1.4506 
                 1.2351 
               
               
                 1KG 
                 rs7623235 
                 2.27E−05 
                 0.08935 
                 0.127 
                 1.2556 
                 1.301 
                 1.149 
               
               
                 1KG 
                 chr4: 23188024 
                 0.0001418 
                 0.008275 
                 0.6592 
                 0.776 
                 0.7626 
                 0.7846 
               
               
                 1KG 
                 rs12908430 
                 0.001121 
                 0.001758 
                 0.6615 
                 0.7128 
                 0.7338 
                 0.6801 
               
               
                 1KG 
                 chr17: 72483712 
                 0.0001566 
                 0.02176 
                 0.6626 
                 1.5837 
                 1.6182 
                 1.474 
               
               
                 1KG 
                 rs6679773 
                 0.0007085 
                 NA 
                 0.2521 
                 2.7548 
                 2.4969 
                 NA 
               
               
                 1KG 
                 chr1: 163986967 
                 0.002678 
                 0.0001905 
                 0.1079 
                 0.5731 
                 0.6343 
                 0.4391 
               
               
                 1KG 
                 rs7958529 
                 0.0002342 
                 0.005289 
                 0.9156 
                 1.2499 
                 1.2553 
                 1.2528 
               
               
                 1KG 
                 chr2: 44132778 
                 0.0007818 
                 0.00185 
                 0.6138 
                 1.4121 
                 1.38 
                 1.4963 
               
               
                 1KG 
                 chr5: 113645446 
                 0.001329 
                 0.0003113 
                 0.3121 
                 0.7765 
                 0.7985 
                 0.7276 
               
               
                 1KG 
                 rs11067403 
                 6.74E−06 
                 0.3045 
                 0.02498 
                 1.1924 
                 1.2475 
                 1.0668 
               
               
                 1KG 
                 rs343718 
                 9.88E−05 
                 0.03219 
                 0.4837 
                 0.8397 
                 0.8269 
                 0.8738 
               
               
                 1KG 
                 rs6685751 
                 0.0001216 
                 0.007157 
                 0.9407 
                 1.266 
                 1.285 
                 1.2611 
               
               
                 1KG 
                 rs1492116 
                 2.06E−05 
                 0.07507 
                 0.1982 
                 1.2137 
                 1.2623 
                 1.1328 
               
               
                 1KG 
                 rs5015852 
                 0.0009123 
                 0.001753 
                 0.4059 
                 1.716 
                 1.644 
                 1.8914 
               
               
                 1KG 
                 chr19: 14775139 
                 0.0004184 
                 0.004882 
                 0.8877 
                 0.708 
                 0.7105 
                 0.6955 
               
               
                 1KG 
                 chr11: 124212812 
                 0.0005409 
                 0.003229 
                 0.8919 
                 1.5975 
                 1.5668 
                 1.6409 
               
               
                 1KG 
                 rs10503493 
                 0.001999 
                 0.001334 
                 0.2556 
                 0.6846 
                 0.7204 
                 0.6176 
               
               
                 1KG 
                 chr4: 86206508 
                 0.01383 
                 8.39E−06 
                 0.006801 
                 0.6116 
                 0.7161 
                 0.4061 
               
               
                 1KG 
                 rs2883171 
                 0.0002656 
                 0.008738 
                 0.7083 
                 0.778 
                 0.7754 
                 0.7889 
               
               
                 1KG 
                 rs1360751 
                 0.001726 
                 0.000897 
                 0.4273 
                 1.1766 
                 1.1543 
                 1.2186 
               
               
                 1KG 
                 rs2024393 
                 0.00273 
                 4.13E−05 
                 0.05154 
                 1.5306 
                 1.4228 
                 1.8503 
               
               
                 1KG 
                 rs4260755 
                 0.0002045 
                 0.01893 
                 0.6182 
                 1.2012 
                 1.2095 
                 1.1714 
               
               
                 1KG 
                 rs17408651 
                 0.0001251 
                 0.01571 
                 0.6615 
                 0.6938 
                 0.6705 
                 0.72 
               
               
                 1KG 
                 rs13192030 
                 0.001041 
                 0.002687 
                 0.5341 
                 1.6219 
                 1.565 
                 1.7468 
               
               
                 1KG 
                 rs12632105 
                 0.1604 
                 2.08E−08 
                 8.73E−05 
                 1.2491 
                 1.0953 
                 1.5345 
               
               
                 1KG 
                 chr1: 85757359 
                 0.00292 
                 0.0008545 
                 0.2963 
                 0.6962 
                 0.7345 
                 0.6301 
               
               
                 1KG 
                 chr10: 57479107 
                 0.0008563 
                 0.001329 
                 0.7289 
                 1.2908 
                 1.272 
                 1.3383 
               
               
                 1KG 
                 rs7094579 
                 0.0003193 
                 0.02934 
                 0.6434 
                 0.6999 
                 0.6898 
                 0.7454 
               
               
                 1KG 
                 chr15: 35201758 
                 4.56E−05 
                 0.06212 
                 0.3605 
                 1.3907 
                 1.4609 
                 1.2538 
               
               
                 1KG 
                 chr6: 162467903 
                 9.40E−05 
                 0.1299 
                 0.1733 
                 0.7609 
                 0.7339 
                 0.8582 
               
               
                 1KG 
                 chr8: 40099493 
                 0.0003539 
                 0.00656 
                 0.9092 
                 0.614 
                 0.6125 
                 0.6257 
               
               
                 1KG 
                 rs16822447 
                 1.06E−05 
                 0.1821 
                 0.05002 
                 1.2811 
                 1.3679 
                 1.1293 
               
               
                 1KG 
                 rs135912 
                 0.0003393 
                 0.01279 
                 0.7976 
                 1.2967 
                 1.306 
                 1.2762 
               
               
                 1KG 
                 chr5: 149749881 
                 0.0003726 
                 0.004751 
                 0.8373 
                 1.3802 
                 1.3859 
                 1.3849 
               
               
                 1KG 
                 rs2135548 
                 0.0007483 
                 0.003939 
                 0.6911 
                 0.8336 
                 0.8399 
                 0.8252 
               
               
                 1KG 
                 rs1358395 
                 0.0002692 
                 0.007593 
                 0.9665 
                 0.8423 
                 0.8352 
                 0.8421 
               
               
                 1KG 
                 chr3: 126793536 
                 0.002748 
                 0.001379 
                 0.5783 
                 1.8746 
                 1.7224 
                 2.1493 
               
               
                 1KG 
                 rs625761 
                 0.008243 
                 4.33E−05 
                 0.04509 
                 1.2134 
                 1.1575 
                 1.3536 
               
               
                 1KG 
                 rs1540819 
                 3.59E−05 
                 0.1277 
                 0.0718 
                 1.172 
                 1.2073 
                 1.0942 
               
               
                 1KG 
                 rs4073997 
                 9.93E−07 
                 0.4996 
                 0.01417 
                 1.2642 
                 1.3908 
                 1.0609 
               
               
                 1KG 
                 chr1: 59476907 
                 0.001353 
                 0.001893 
                 0.5084 
                 0.571 
                 0.5938 
                 0.5152 
               
               
                 HM3 
                 rs16965939 
                 6.28E−05 
                 9.95E−05 
                 0.4187 
                 0.6414 
                 0.6589 
                 0.5837 
               
               
                 HM3 
                 rs1999930 
                 1.79E−05 
                 0.001342 
                 0.9695 
                 0.8066 
                 0.804 
                 0.8089 
               
               
                 HM3 
                 rs1789110 
                 0.003144 
                 8.23E−08 
                 0.002278 
                 0.8206 
                 0.8707 
                 0.7249 
               
               
                 HM3 
                 rs10280782 
                 7.34E−07 
                 0.0713 
                 0.04504 
                 1.3258 
                 1.4061 
                 1.1675 
               
               
                 HM3 
                 rs1079982 
                 0.0001407 
                 0.0006923 
                 0.4598 
                 0.6454 
                 0.6686 
                 0.6092 
               
               
                 HM3 
                 rs11854658 
                 2.53E−05 
                 0.005429 
                 0.6806 
                 1.2181 
                 1.2244 
                 1.1896 
               
               
                 HM3 
                 rs8076470 
                 2.31E−05 
                 0.001837 
                 0.8181 
                 1.2139 
                 1.2196 
                 1.2087 
               
               
                 HM3 
                 rs8053796 
                 0.0002953 
                 4.88E−05 
                 0.1967 
                 1.2672 
                 1.2299 
                 1.3492 
               
               
                 HM3 
                 rs2037156 
                 4.59E−05 
                 0.004051 
                 0.6462 
                 0.7899 
                 0.7875 
                 0.8049 
               
               
                 HM3 
                 rs3760775 
                 0.0002587 
                 0.001212 
                 0.4955 
                 0.6626 
                 0.6787 
                 0.6266 
               
               
                 HM3 
                 rs9291737 
                 7.45E−05 
                 0.002397 
                 0.6956 
                 1.1971 
                 1.2005 
                 1.2005 
               
               
                 HM3 
                 rs13094238 
                 0.003017 
                 6.57E−06 
                 0.02605 
                 1.4804 
                 1.345 
                 1.8713 
               
               
                 HM3 
                 rs2730613 
                 0.0003072 
                 0.0003156 
                 0.3924 
                 1.2048 
                 1.1886 
                 1.2562 
               
               
                 HM3 
                 rs10103808 
                 4.36E−05 
                 0.007698 
                 0.8279 
                 0.7472 
                 0.7342 
                 0.7717 
               
               
                 HM3 
                 rs7720497 
                 9.58E−05 
                 0.002133 
                 0.956 
                 0.6878 
                 0.6842 
                 0.6888 
               
               
                 HM3 
                 rs6531212 
                 1.54E−05 
                 0.04856 
                 0.2214 
                 0.8334 
                 0.8124 
                 0.8837 
               
               
                 HM3 
                 rs8011890 
                 0.0004883 
                 0.0002716 
                 0.3724 
                 1.4104 
                 1.3647 
                 1.5103 
               
               
                 HM3 
                 rs12926103 
                 0.0001097 
                 0.003454 
                 0.8956 
                 1.4075 
                 1.415 
                 1.3989 
               
               
                 HM3 
                 rs16971055 
                 0.0005136 
                 0.0009973 
                 0.6898 
                 1.5452 
                 1.494 
                 1.6131 
               
               
                 HM3 
                 rs1912795 
                 6.87E−05 
                 0.01009 
                 0.8198 
                 1.1918 
                 1.2068 
                 1.1709 
               
               
                 HM3 
                 rs2127740 
                 0.0002762 
                 0.002813 
                 0.9732 
                 1.2942 
                 1.2848 
                 1.3023 
               
               
                 HM3 
                 rs17155281 
                 0.001612 
                 0.0001765 
                 0.1384 
                 1.2603 
                 1.2171 
                 1.3623 
               
               
                 HM3 
                 rs4256145 
                 0.0004254 
                 0.001256 
                 0.5498 
                 1.1948 
                 1.1844 
                 1.2273 
               
               
                 HM3 
                 rs6587759 
                 2.45E−05 
                 0.05012 
                 0.2593 
                 1.4444 
                 1.5104 
                 1.2886 
               
               
                 HM3 
                 rs2052572 
                 0.0002378 
                 0.003662 
                 0.8437 
                 1.1942 
                 1.195 
                 1.1989 
               
               
                 HM3 
                 rs13278062 
                 1.40E−06 
                 0.345 
                 0.01412 
                 1.2206 
                 1.3017 
                 1.0697 
               
               
                 HM3 
                 rs722782 
                 0.01492 
                 1.21E−06 
                 0.001233 
                 0.7568 
                 0.8319 
                 0.5781 
               
               
                 HM3 
                 rs1867348 
                 0.003738 
                 1.45E−05 
                 0.04783 
                 1.3447 
                 1.2675 
                 1.5481 
               
               
                 HM3 
                 rs9461856 
                 0.001189 
                 0.0004144 
                 0.3166 
                 0.849 
                 0.863 
                 0.8126 
               
               
                 HM3 
                 rs2270637 
                 0.0004731 
                 0.002846 
                 0.7084 
                 1.2348 
                 1.2282 
                 1.2596 
               
               
                 HM3 
                 rs2798832 
                 0.0001696 
                 0.006426 
                 0.9931 
                 1.2184 
                 1.2283 
                 1.2099 
               
               
                 HM3 
                 rs12632671 
                 2.52E−06 
                 0.5699 
                 0.002276 
                 1.5035 
                 1.6643 
                 1.0939 
               
               
                 HM3 
                 rs9713311 
                 0.001113 
                 0.0003867 
                 0.4046 
                 0.8472 
                 0.8606 
                 0.8096 
               
               
                 HM3 
                 rs7626245 
                 0.0001847 
                 0.005226 
                 0.8963 
                 1.3626 
                 1.377 
                 1.3483 
               
               
                 HM3 
                 rs513683 
                 0.0008254 
                 0.003938 
                 0.7375 
                 0.8496 
                 0.8578 
                 0.8406 
               
               
                 HM3 
                 rs2376241 
                 0.0009555 
                 0.0004383 
                 0.2413 
                 1.201 
                 1.1867 
                 1.2611 
               
               
                 HM3 
                 rs251525 
                 0.004244 
                 0.0004694 
                 0.3072 
                 0.842 
                 0.8698 
                 0.8035 
               
               
                 HM3 
                 rs1737478 
                 0.00017 
                 0.02088 
                 0.6004 
                 1.2064 
                 1.2208 
                 1.1724 
               
               
                 HM3 
                 rs7783337 
                 0.003599 
                 0.0001757 
                 0.1258 
                 0.7876 
                 0.8221 
                 0.7259 
               
               
                 HM3 
                 rs10225927 
                 0.0003114 
                 0.004791 
                 0.9041 
                 0.8221 
                 0.8187 
                 0.8162 
               
               
                 HM3 
                 rs164700 
                 0.001207 
                 0.001887 
                 0.6632 
                 1.268 
                 1.242 
                 1.3067 
               
               
                 HM3 
                 rs10848645 
                 0.003688 
                 0.0005319 
                 0.3002 
                 0.8371 
                 0.863 
                 0.7959 
               
               
                   
               
             
          
           
               
                 IMP 
                 SNP 
                 OR_4vs5 
                 SE_1vs45 
                 SE_1vs5 
                 SE_1vs4 
                 SE_4vs5 
                 INFO_1vs45 
               
               
                   
               
               
                 1KG 
                 rs1367068 
                 1.05 
                 0.0593 
                 0.0671 
                 0.0864 
                 0.0936 
                 0.7032 
               
               
                 1KG 
                 rs1443179 
                 0.8045 
                 0.1051 
                 0.1176 
                 0.1408 
                 0.1415 
                 0.5996 
               
               
                 1KG 
                 rs9328048 
                 0.9758 
                 0.0535 
                 0.0595 
                 0.0781 
                 0.0824 
                 0.603 
               
               
                 1KG 
                 chr4: 182189551 
                 0.6905 
                 0.1174 
                 0.1287 
                 0.1713 
                 0.1765 
                 0.3073 
               
               
                 1KG 
                 rs1915098 
                 1.1208 
                 0.0517 
                 0.0574 
                 0.0773 
                 0.0833 
                 0.9527 
               
               
                 1KG 
                 rs1418473 
                 0.7574 
                 0.0963 
                 0.1085 
                 0.1266 
                 0.1277 
                 0.7571 
               
               
                 1KG 
                 rs11183802 
                 1.209 
                 0.0801 
                 0.0877 
                 0.1169 
                 0.1208 
                 0.6692 
               
               
                 1KG 
                 rs728371 
                 0.9512 
                 0.0451 
                 0.0502 
                 0.0646 
                 0.0669 
                 0.912 
               
               
                 1KG 
                 chr11: 1768072 
                 0.9527 
                 0.0626 
                 0.0703 
                 0.0918 
                 0.1 
                 0.7808 
               
               
                 1KG 
                 rs11596472 
                 1.2672 
                 0.0769 
                 0.085 
                 0.1093 
                 0.113 
                 0.4398 
               
               
                 1KG 
                 rs6982567 
                 1.0684 
                 0.0616 
                 0.0671 
                 0.0904 
                 0.0887 
                 0.8663 
               
               
                 1KG 
                 rs2277252 
                 1.0028 
                 0.0467 
                 0.0517 
                 0.0673 
                 0.0714 
                 0.7486 
               
               
                 1KG 
                 rs8091635 
                 1.2164 
                 0.0493 
                 0.0546 
                 0.0714 
                 0.0753 
                 0.7131 
               
               
                 1KG 
                 rs9366769 
                 0.935 
                 0.0504 
                 0.0564 
                 0.0746 
                 0.0798 
                 0.9597 
               
               
                 1KG 
                 rs5771717 
                 0.619 
                 0.07 
                 0.0815 
                 0.0907 
                 0.0967 
                 0.9131 
               
               
                 1KG 
                 chr22: 33891064 
                 0.8256 
                 0.1516 
                 0.1755 
                 0.223 
                 0.2512 
                 0.2964 
               
               
                 1KG 
                 chr5: 165133520 
                 1.0415 
                 0.0549 
                 0.0622 
                 0.0805 
                 0.0869 
                 0.939 
               
               
                 1KG 
                 chr3: 116361297 
                 0.9288 
                 0.0702 
                 0.0794 
                 0.1029 
                 0.1098 
                 0.5552 
               
               
                 1KG 
                 rs17071512 
                 1.1656 
                 0.0773 
                 0.0887 
                 0.1108 
                 0.125 
                 0.7041 
               
               
                 1KG 
                 rs1384044 
                 1.0241 
                 0.0411 
                 0.0459 
                 0.0597 
                 0.0629 
                 0.9648 
               
               
                 1KG 
                 rs9308649 
                 0.9256 
                 0.0503 
                 0.0561 
                 0.075 
                 0.0807 
                 1.0129 
               
               
                 1KG 
                 rs10067691 
                 0.9027 
                 0.0927 
                 0.1056 
                 0.1351 
                 0.1483 
                 0.5304 
               
               
                 1KG 
                 chr1: 100166675 
                 0.9069 
                 0.0946 
                 0.1062 
                 0.1285 
                 0.1294 
                 0.9209 
               
               
                 1KG 
                 rs10768315 
                 0.9969 
                 0.0506 
                 0.0562 
                 0.0746 
                 0.0789 
                 0.9621 
               
               
                 1KG 
                 chr10: 88344492 
                 1.0785 
                 0.0592 
                 0.0655 
                 0.0847 
                 0.0888 
                 0.91 
               
               
                 1KG 
                 rs7260457 
                 1.2508 
                 0.1146 
                 0.1273 
                 0.1748 
                 0.1867 
                 0.1927 
               
               
                 1KG 
                 chr12: 11233234 
                 0.9674 
                 0.0591 
                 0.0648 
                 0.0847 
                 0.087 
                 0.5826 
               
               
                 1KG 
                 rs2491146 
                 1.0885 
                 0.0461 
                 0.0516 
                 0.067 
                 0.0718 
                 0.7785 
               
               
                 1KG 
                 chr16: 17310751 
                 0.9766 
                 0.0787 
                 0.0886 
                 0.1168 
                 0.1273 
                 0.7538 
               
               
                 1KG 
                 rs4711751 
                 0.9686 
                 0.0472 
                 0.0522 
                 0.0694 
                 0.0711 
                 0.7326 
               
               
                 1KG 
                 chr11: 104185708 
                 1.0996 
                 0.187 
                 0.208 
                 0.2677 
                 0.2762 
                 0.1749 
               
               
                 1KG 
                 rs1851808 
                 0.9521 
                 0.0425 
                 0.0476 
                 0.0609 
                 0.0649 
                 0.9525 
               
               
                 1KG 
                 rs13253938 
                 0.9875 
                 0.0451 
                 0.0506 
                 0.065 
                 0.0693 
                 0.8145 
               
               
                 1KG 
                 rs529478 
                 1.0503 
                 0.046 
                 0.0512 
                 0.0665 
                 0.0697 
                 0.7669 
               
               
                 1KG 
                 rs12798294 
                 0.9841 
                 0.0465 
                 0.0521 
                 0.0674 
                 0.0726 
                 0.9005 
               
               
                 1KG 
                 chr8: 123521912 
                 1.3131 
                 0.1391 
                 0.1533 
                 0.2027 
                 0.2071 
                 0.2493 
               
               
                 1KG 
                 rs28621471 
                 0.9115 
                 0.0661 
                 0.0736 
                 0.0962 
                 0.1018 
                 0.4485 
               
               
                 1KG 
                 chr15: 47957127 
                 1.2761 
                 0.098 
                 0.1094 
                 0.1532 
                 0.1641 
                 0.548 
               
               
                 1KG 
                 chr5: 26212150 
                 0.9743 
                 0.0861 
                 0.0973 
                 0.1308 
                 0.1388 
                 0.8648 
               
               
                 1KG 
                 chr2: 180796214 
                 1.007 
                 0.0519 
                 0.0585 
                 0.076 
                 0.0812 
                 0.9746 
               
               
                 1KG 
                 rs4967980 
                 1.0468 
                 0.0498 
                 0.0553 
                 0.071 
                 0.0741 
                 0.9209 
               
               
                 1KG 
                 chr6: 119117772 
                 1.2821 
                 0.0819 
                 0.0908 
                 0.1272 
                 0.1371 
                 0.6885 
               
               
                 1KG 
                 rs12520598 
                 1.1972 
                 0.0859 
                 0.0963 
                 0.1318 
                 0.1392 
                 0.6284 
               
               
                 1KG 
                 chr10: 56380194 
                 1.0826 
                 0.1263 
                 0.1394 
                 0.1778 
                 0.1771 
                 0.2768 
               
               
                 1KG 
                 chr12: 8919954 
                 1.3077 
                 0.1803 
                 0.2035 
                 0.261 
                 0.2845 
                 0.1932 
               
               
                 1KG 
                 rs11592003 
                 0.8948 
                 0.0573 
                 0.0638 
                 0.0866 
                 0.0926 
                 0.9071 
               
               
                 1KG 
                 rs235195 
                 1.1619 
                 0.0775 
                 0.0856 
                 0.1119 
                 0.1176 
                 0.5644 
               
               
                 1KG 
                 rs7623235 
                 1.1385 
                 0.0562 
                 0.0621 
                 0.0818 
                 0.085 
                 0.7698 
               
               
                 1KG 
                 chr4: 23188024 
                 0.957 
                 0.0627 
                 0.0712 
                 0.0919 
                 0.0996 
                 0.795 
               
               
                 1KG 
                 rs12908430 
                 1.0615 
                 0.0838 
                 0.095 
                 0.1233 
                 0.1362 
                 0.463 
               
               
                 1KG 
                 chr17: 72483712 
                 1.0827 
                 0.1137 
                 0.1273 
                 0.1691 
                 0.1821 
                 0.5091 
               
               
                 1KG 
                 rs6679773 
                 0.7295 
                 0.2507 
                 0.2702 
                 NA 
                 0.2753 
                 0.1192 
               
               
                 1KG 
                 chr1: 163986967 
                 1.4572 
                 0.1379 
                 0.1516 
                 0.2206 
                 0.2342 
                 0.3787 
               
               
                 1KG 
                 rs7958529 
                 0.9908 
                 0.0553 
                 0.0618 
                 0.0808 
                 0.087 
                 0.6987 
               
               
                 1KG 
                 chr2: 44132778 
                 0.9334 
                 0.0856 
                 0.0959 
                 0.1294 
                 0.1366 
                 0.5156 
               
               
                 1KG 
                 chr5: 113645446 
                 1.0967 
                 0.0627 
                 0.0701 
                 0.0882 
                 0.0913 
                 0.8665 
               
               
                 1KG 
                 rs11067403 
                 1.163 
                 0.0437 
                 0.0491 
                 0.063 
                 0.0673 
                 0.9642 
               
               
                 1KG 
                 rs343718 
                 0.9543 
                 0.0434 
                 0.0488 
                 0.063 
                 0.0669 
                 0.9767 
               
               
                 1KG 
                 rs6685751 
                 1.0067 
                 0.0588 
                 0.0653 
                 0.0863 
                 0.0895 
                 0.474 
               
               
                 1KG 
                 rs1492116 
                 1.101 
                 0.0485 
                 0.0547 
                 0.0701 
                 0.0748 
                 1.0041 
               
               
                 1KG 
                 rs5015852 
                 0.8311 
                 0.1352 
                 0.1499 
                 0.2037 
                 0.2225 
                 0.2025 
               
               
                 1KG 
                 chr19: 14775139 
                 1.0195 
                 0.0865 
                 0.0969 
                 0.129 
                 0.1367 
                 0.5933 
               
               
                 1KG 
                 chr11: 124212812 
                 0.9775 
                 0.1175 
                 0.1298 
                 0.1682 
                 0.1678 
                 0.3298 
               
               
                 1KG 
                 rs10503493 
                 1.1983 
                 0.0951 
                 0.1061 
                 0.1502 
                 0.1591 
                 0.9801 
               
               
                 1KG 
                 chr4: 86206508 
                 1.7899 
                 0.1236 
                 0.1357 
                 0.2023 
                 0.2151 
                 0.4013 
               
               
                 1KG 
                 rs2883171 
                 0.9659 
                 0.0633 
                 0.0698 
                 0.0904 
                 0.0927 
                 0.9269 
               
               
                 1KG 
                 rs1360751 
                 0.9508 
                 0.041 
                 0.0458 
                 0.0595 
                 0.0636 
                 0.975 
               
               
                 1KG 
                 rs2024393 
                 0.745 
                 0.1074 
                 0.1177 
                 0.1501 
                 0.1512 
                 0.3005 
               
               
                 1KG 
                 rs4260755 
                 1.0355 
                 0.0463 
                 0.0512 
                 0.0674 
                 0.07 
                 0.8224 
               
               
                 1KG 
                 rs17408651 
                 0.9376 
                 0.0923 
                 0.1042 
                 0.136 
                 0.147 
                 0.4815 
               
               
                 1KG 
                 rs13192030 
                 0.8833 
                 0.1225 
                 0.1366 
                 0.1858 
                 0.1996 
                 0.3052 
               
               
                 1KG 
                 rs12632105 
                 0.7223 
                 0.0564 
                 0.0649 
                 0.0764 
                 0.0829 
                 0.9082 
               
               
                 1KG 
                 chr1: 85757359 
                 1.1698 
                 0.092 
                 0.1037 
                 0.1385 
                 0.1502 
                 0.4938 
               
               
                 1KG 
                 chr10: 57479107 
                 0.9682 
                 0.0649 
                 0.0722 
                 0.0908 
                 0.0933 
                 1.0046 
               
               
                 1KG 
                 rs7094579 
                 0.934 
                 0.0907 
                 0.1032 
                 0.1348 
                 0.1474 
                 0.998 
               
               
                 1KG 
                 chr15: 35201758 
                 1.1228 
                 0.0841 
                 0.093 
                 0.1213 
                 0.1267 
                 0.4822 
               
               
                 1KG 
                 chr6: 162467903 
                 0.8594 
                 0.0697 
                 0.0792 
                 0.101 
                 0.1113 
                 0.8954 
               
               
                 1KG 
                 chr8: 40099493 
                 0.98 
                 0.1245 
                 0.1372 
                 0.1725 
                 0.1772 
                 0.3212 
               
               
                 1KG 
                 rs16822447 
                 1.2109 
                 0.0633 
                 0.0711 
                 0.0911 
                 0.0976 
                 0.7434 
               
               
                 1KG 
                 rs135912 
                 1.0272 
                 0.0664 
                 0.0745 
                 0.098 
                 0.1047 
                 0.6941 
               
               
                 1KG 
                 chr5: 149749881 
                 0.9765 
                 0.0824 
                 0.0917 
                 0.1153 
                 0.1158 
                 0.9777 
               
               
                 1KG 
                 rs2135548 
                 1.028 
                 0.0466 
                 0.0518 
                 0.0666 
                 0.0695 
                 0.9989 
               
               
                 1KG 
                 rs1358395 
                 0.9972 
                 0.0439 
                 0.0494 
                 0.0644 
                 0.0675 
                 0.9751 
               
               
                 1KG 
                 chr3: 126793536 
                 0.8615 
                 0.1611 
                 0.1816 
                 0.2392 
                 0.2683 
                 0.2409 
               
               
                 1KG 
                 rs625761 
                 0.8525 
                 0.0496 
                 0.0554 
                 0.074 
                 0.0796 
                 0.9312 
               
               
                 1KG 
                 rs1540819 
                 1.1184 
                 0.0407 
                 0.0456 
                 0.0591 
                 0.0622 
                 0.9813 
               
               
                 1KG 
                 rs4073997 
                 1.2513 
                 0.0602 
                 0.0674 
                 0.0876 
                 0.0914 
                 0.57 
               
               
                 1KG 
                 chr1: 59476907 
                 1.1589 
                 0.1439 
                 0.1627 
                 0.2135 
                 0.223 
                 0.2323 
               
               
                 HM3 
                 rs16965939 
                 1.1299 
                 0.0912 
                 0.1043 
                 0.1383 
                 0.151 
                 0.6082 
               
               
                 HM3 
                 rs1999930 
                 1.0028 
                 0.0454 
                 0.0509 
                 0.0661 
                 0.0721 
                 0.9854 
               
               
                 HM3 
                 rs1789110 
                 1.2138 
                 0.0419 
                 0.0469 
                 0.06 
                 0.0635 
                 0.9738 
               
               
                 HM3 
                 rs10280782 
                 1.2048 
                 0.06 
                 0.0688 
                 0.0859 
                 0.093 
                 0.9737 
               
               
                 HM3 
                 rs1079982 
                 1.1237 
                 0.0938 
                 0.1057 
                 0.1461 
                 0.1578 
                 0.9122 
               
               
                 HM3 
                 rs11854658 
                 1.0274 
                 0.0427 
                 0.0481 
                 0.0624 
                 0.0656 
                 0.9903 
               
               
                 HM3 
                 rs8076470 
                 1.0148 
                 0.042 
                 0.0469 
                 0.0609 
                 0.0637 
                 0.9768 
               
               
                 HM3 
                 rs8053796 
                 0.9076 
                 0.0516 
                 0.0572 
                 0.0738 
                 0.0751 
                 0.814 
               
               
                 HM3 
                 rs2037156 
                 0.9649 
                 0.0528 
                 0.0586 
                 0.0755 
                 0.0779 
                 0.9516 
               
               
                 HM3 
                 rs3760775 
                 1.1136 
                 0.0943 
                 0.1061 
                 0.1445 
                 0.1579 
                 0.8707 
               
               
                 HM3 
                 rs9291737 
                 1.0253 
                 0.0413 
                 0.0461 
                 0.0602 
                 0.0638 
                 0.9946 
               
               
                 HM3 
                 rs13094238 
                 0.724 
                 0.0902 
                 0.0999 
                 0.139 
                 0.1451 
                 0.4071 
               
               
                 HM3 
                 rs2730613 
                 0.9445 
                 0.043 
                 0.0479 
                 0.0633 
                 0.0668 
                 0.9664 
               
               
                 HM3 
                 rs10103808 
                 0.9787 
                 0.0682 
                 0.0756 
                 0.0972 
                 0.0992 
                 0.9801 
               
               
                 HM3 
                 rs7720497 
                 1.0069 
                 0.0879 
                 0.0973 
                 0.1214 
                 0.1251 
                 0.9157 
               
               
                 HM3 
                 rs6531212 
                 0.9223 
                 0.0429 
                 0.0481 
                 0.0627 
                 0.0662 
                 0.9957 
               
               
                 HM3 
                 rs8011890 
                 0.9032 
                 0.0813 
                 0.0892 
                 0.1132 
                 0.1141 
                 0.76 
               
               
                 HM3 
                 rs12926103 
                 1.0152 
                 0.0814 
                 0.0897 
                 0.1148 
                 0.115 
                 0.9923 
               
               
                 HM3 
                 rs16971055 
                 0.9425 
                 0.1039 
                 0.1156 
                 0.1453 
                 0.1485 
                 0.4562 
               
               
                 HM3 
                 rs1912795 
                 1.0147 
                 0.0422 
                 0.0472 
                 0.0613 
                 0.0639 
                 0.9338 
               
               
                 HM3 
                 rs2127740 
                 0.9969 
                 0.0621 
                 0.0689 
                 0.0884 
                 0.091 
                 0.954 
               
               
                 HM3 
                 rs17155281 
                 0.8778 
                 0.0558 
                 0.0623 
                 0.0824 
                 0.088 
                 0.6339 
               
               
                 HM3 
                 rs4256145 
                 0.9604 
                 0.0431 
                 0.048 
                 0.0635 
                 0.0675 
                 1.0075 
               
               
                 HM3 
                 rs6587759 
                 1.1619 
                 0.0897 
                 0.0977 
                 0.1294 
                 0.133 
                 0.8574 
               
               
                 HM3 
                 rs2052572 
                 0.9872 
                 0.0434 
                 0.0485 
                 0.0624 
                 0.0653 
                 0.9884 
               
               
                 HM3 
                 rs13278062 
                 1.2001 
                 0.0492 
                 0.0547 
                 0.0713 
                 0.0743 
                 0.6759 
               
               
                 HM3 
                 rs722782 
                 1.4737 
                 0.0689 
                 0.0756 
                 0.1129 
                 0.12 
                 1.0109 
               
               
                 HM3 
                 rs1867348 
                 0.8191 
                 0.0732 
                 0.0817 
                 0.1008 
                 0.1008 
                 0.9916 
               
               
                 HM3 
                 rs9461856 
                 1.0634 
                 0.0405 
                 0.0455 
                 0.0588 
                 0.0614 
                 0.993 
               
               
                 HM3 
                 rs2270637 
                 0.9701 
                 0.0523 
                 0.0588 
                 0.0774 
                 0.0813 
                 0.987 
               
               
                 HM3 
                 rs2798832 
                 0.9994 
                 0.049 
                 0.0547 
                 0.0699 
                 0.0741 
                 0.9099 
               
               
                 HM3 
                 rs12632671 
                 1.6012 
                 0.1014 
                 0.1082 
                 0.158 
                 0.1543 
                 0.8674 
               
               
                 HM3 
                 rs9713311 
                 1.0534 
                 0.0413 
                 0.0461 
                 0.0595 
                 0.0624 
                 1.0053 
               
               
                 HM3 
                 rs7626245 
                 0.9855 
                 0.0776 
                 0.0856 
                 0.107 
                 0.1117 
                 0.9805 
               
               
                 HM3 
                 rs513683 
                 1.0213 
                 0.0412 
                 0.0459 
                 0.0602 
                 0.0629 
                 0.977 
               
               
                 HM3 
                 rs2376241 
                 0.9227 
                 0.0464 
                 0.0518 
                 0.066 
                 0.0686 
                 0.9894 
               
               
                 HM3 
                 rs251525 
                 1.0694 
                 0.0436 
                 0.0488 
                 0.0626 
                 0.0657 
                 0.9707 
               
               
                 HM3 
                 rs1737478 
                 1.038 
                 0.0477 
                 0.0531 
                 0.0689 
                 0.0712 
                 0.9949 
               
               
                 HM3 
                 rs7783337 
                 1.1463 
                 0.0609 
                 0.0673 
                 0.0854 
                 0.0892 
                 0.898 
               
               
                 HM3 
                 rs10225927 
                 1.009 
                 0.05 
                 0.0555 
                 0.072 
                 0.074 
                 0.9991 
               
               
                 HM3 
                 rs164700 
                 0.9624 
                 0.0607 
                 0.067 
                 0.0861 
                 0.0879 
                 0.8491 
               
               
                 HM3 
                 rs10848645 
                 1.0736 
                 0.0455 
                 0.0507 
                 0.0659 
                 0.0685 
                 0.7975 
               
               
                   
               
             
          
           
               
                   
                 IMP 
                 SNP 
                 INFO_1vs5 
                 INFO_1vs4 
                 INFO_4vs5 
               
               
                   
                   
               
               
                   
                 1KG 
                 rs1367068 
                 0.701 
                 0.7097 
                 0.6902 
               
               
                   
                 1KG 
                 rs1443179 
                 0.5865 
                 0.5875 
                 0.6346 
               
               
                   
                 1KG 
                 rs9328048 
                 0.6044 
                 0.5908 
                 0.6095 
               
               
                   
                 1KG 
                 chr4: 182189551 
                 0.3099 
                 0.2981 
                 0.3154 
               
               
                   
                 1KG 
                 rs1915098 
                 0.956 
                 0.962 
                 0.9292 
               
               
                   
                 1KG 
                 rs1418473 
                 0.7416 
                 0.7721 
                 0.7609 
               
               
                   
                 1KG 
                 rs11183802 
                 0.6758 
                 0.685 
                 0.6375 
               
               
                   
                 1KG 
                 rs728371 
                 0.9043 
                 0.8945 
                 0.9401 
               
               
                   
                 1KG 
                 chr11: 1768072 
                 0.7891 
                 0.7778 
                 0.7614 
               
               
                   
                 1KG 
                 rs11596472 
                 0.4412 
                 0.4301 
                 0.4473 
               
               
                   
                 1KG 
                 rs6982567 
                 0.866 
                 0.8051 
                 0.9272 
               
               
                   
                 1KG 
                 rs2277252 
                 0.7457 
                 0.7329 
                 0.762 
               
               
                   
                 1KG 
                 rs8091635 
                 0.7163 
                 0.6982 
                 0.7201 
               
               
                   
                 1KG 
                 rs9366769 
                 0.9573 
                 0.9635 
                 0.9565 
               
               
                   
                 1KG 
                 rs5771717 
                 0.8874 
                 0.937 
                 0.9215 
               
               
                   
                 1KG 
                 chr22: 33891064 
                 0.3013 
                 0.3132 
                 0.2499 
               
               
                   
                 1KG 
                 chr5: 165133520 
                 0.9377 
                 0.9432 
                 0.9289 
               
               
                   
                 1KG 
                 chr3: 116361297 
                 0.5605 
                 0.5658 
                 0.533 
               
               
                   
                 1KG 
                 rs17071512 
                 0.713 
                 0.7334 
                 0.6406 
               
               
                   
                 1KG 
                 rs1384044 
                 0.9636 
                 0.9606 
                 0.9688 
               
               
                   
                 1KG 
                 rs9308649 
                 1.0142 
                 1.0187 
                 0.9984 
               
               
                   
                 1KG 
                 rs10067691 
                 0.5326 
                 0.5419 
                 0.5069 
               
               
                   
                 1KG 
                 chr1: 100166675 
                 0.9053 
                 0.9111 
                 0.955 
               
               
                   
                 1KG 
                 rs10768315 
                 0.9572 
                 0.962 
                 0.97 
               
               
                   
                 1KG 
                 chr10: 88344492 
                 0.9101 
                 0.9149 
                 0.8994 
               
               
                   
                 1KG 
                 rs7260457 
                 0.1968 
                 0.1953 
                 0.1797 
               
               
                   
                 1KG 
                 chr12: 11233234 
                 0.5755 
                 0.5496 
                 0.6284 
               
               
                   
                 1KG 
                 rs2491146 
                 0.7784 
                 0.7912 
                 0.759 
               
               
                   
                 1KG 
                 chr16: 17310751 
                 0.7519 
                 0.7696 
                 0.7328 
               
               
                   
                 1KG 
                 rs4711751 
                 0.7298 
                 0.7024 
                 0.7775 
               
               
                   
                 1KG 
                 chr11: 104185708 
                 0.1747 
                 0.1733 
                 0.1779 
               
               
                   
                 1KG 
                 rs1851808 
                 0.9467 
                 0.9713 
                 0.9344 
               
               
                   
                 1KG 
                 rs13253938 
                 0.8181 
                 0.8308 
                 0.7808 
               
               
                   
                 1KG 
                 rs529478 
                 0.7576 
                 0.7498 
                 0.7984 
               
               
                   
                 1KG 
                 rs12798294 
                 0.8976 
                 0.9095 
                 0.8898 
               
               
                   
                 1KG 
                 chr8: 123521912 
                 0.2511 
                 0.2448 
                 0.2515 
               
               
                   
                 1KG 
                 rs28621471 
                 0.4521 
                 0.4409 
                 0.4545 
               
               
                   
                 1KG 
                 chr15: 47957127 
                 0.5498 
                 0.551 
                 0.5348 
               
               
                   
                 1KG 
                 chr5: 26212150 
                 0.8573 
                 0.8674 
                 0.874 
               
               
                   
                 1KG 
                 chr2: 180796214 
                 0.9684 
                 0.9785 
                 0.9832 
               
               
                   
                 1KG 
                 rs4967980 
                 0.9274 
                 0.9152 
                 0.915 
               
               
                   
                 1KG 
                 chr6: 119117772 
                 0.693 
                 0.6975 
                 0.6641 
               
               
                   
                 1KG 
                 rs12520598 
                 0.6309 
                 0.6405 
                 0.6062 
               
               
                   
                 1KG 
                 chr10: 56380194 
                 0.2728 
                 0.258 
                 0.307 
               
               
                   
                 1KG 
                 chr12: 8919954 
                 0.1946 
                 0.1946 
                 0.1885 
               
               
                   
                 1KG 
                 rs11592003 
                 0.9127 
                 0.9064 
                 0.8914 
               
               
                   
                 1KG 
                 rs235195 
                 0.5723 
                 0.5626 
                 0.5544 
               
               
                   
                 1KG 
                 rs7623235 
                 0.7723 
                 0.7628 
                 0.7745 
               
               
                   
                 1KG 
                 chr4: 23188024 
                 0.7915 
                 0.8051 
                 0.7724 
               
               
                   
                 1KG 
                 rs12908430 
                 0.4692 
                 0.4938 
                 0.4086 
               
               
                   
                 1KG 
                 chr17: 72483712 
                 0.5095 
                 0.5126 
                 0.5048 
               
               
                   
                 1KG 
                 rs6679773 
                 0.1066 
                 0.096 
                 0.1671 
               
               
                   
                 1KG 
                 chr1: 163986967 
                 0.3842 
                 0.3754 
                 0.3701 
               
               
                   
                 1KG 
                 rs7958529 
                 0.7005 
                 0.701 
                 0.6906 
               
               
                   
                 1KG 
                 chr2: 44132778 
                 0.5182 
                 0.5121 
                 0.5126 
               
               
                   
                 1KG 
                 chr5: 113645446 
                 0.8625 
                 0.8672 
                 0.8696 
               
               
                   
                 1KG 
                 rs11067403 
                 0.9691 
                 0.963 
                 0.9595 
               
               
                   
                 1KG 
                 rs343718 
                 0.9727 
                 0.9659 
                 0.993 
               
               
                   
                 1KG 
                 rs6685751 
                 0.4764 
                 0.4604 
                 0.4831 
               
               
                   
                 1KG 
                 rs1492116 
                 1.0053 
                 1.0009 
                 1.0057 
               
               
                   
                 1KG 
                 rs5015852 
                 0.2053 
                 0.2065 
                 0.1913 
               
               
                   
                 1KG 
                 chr19: 14775139 
                 0.5939 
                 0.5858 
                 0.6019 
               
               
                   
                 1KG 
                 chr11: 124212812 
                 0.3285 
                 0.3128 
                 0.3544 
               
               
                   
                 1KG 
                 rs10503493 
                 0.9773 
                 0.9755 
                 0.9908 
               
               
                   
                 1KG 
                 chr4: 86206508 
                 0.4071 
                 0.4078 
                 0.372 
               
               
                   
                 1KG 
                 rs2883171 
                 0.9315 
                 0.9061 
                 0.9388 
               
               
                   
                 1KG 
                 rs1360751 
                 0.977 
                 0.9847 
                 0.9519 
               
               
                   
                 1KG 
                 rs2024393 
                 0.2974 
                 0.2803 
                 0.3275 
               
               
                   
                 1KG 
                 rs4260755 
                 0.8232 
                 0.8002 
                 0.8358 
               
               
                   
                 1KG 
                 rs17408651 
                 0.4856 
                 0.4913 
                 0.459 
               
               
                   
                 1KG 
                 rs13192030 
                 0.3099 
                 0.3105 
                 0.2907 
               
               
                   
                 1KG 
                 rs12632105 
                 0.8939 
                 0.9308 
                 0.9044 
               
               
                   
                 1KG 
                 chr1: 85757359 
                 0.4932 
                 0.5197 
                 0.4597 
               
               
                   
                 1KG 
                 chr10: 57479107 
                 0.9966 
                 1.0083 
                 1.0117 
               
               
                   
                 1KG 
                 rs7094579 
                 0.9967 
                 1.0007 
                 0.9927 
               
               
                   
                 1KG 
                 chr15: 35201758 
                 0.4859 
                 0.4789 
                 0.4813 
               
               
                   
                 1KG 
                 chr6: 162467903 
                 0.9 
                 0.9015 
                 0.8717 
               
               
                   
                 1KG 
                 chr8: 40099493 
                 0.3147 
                 0.3094 
                 0.3438 
               
               
                   
                 1KG 
                 rs16822447 
                 0.75 
                 0.7279 
                 0.754 
               
               
                   
                 1KG 
                 rs135912 
                 0.696 
                 0.6876 
                 0.6967 
               
               
                   
                 1KG 
                 chr5: 149749881 
                 0.9678 
                 0.9617 
                 0.9997 
               
               
                   
                 1KG 
                 rs2135548 
                 1.0021 
                 0.9953 
                 0.9968 
               
               
                   
                 1KG 
                 rs1358395 
                 0.9673 
                 0.9727 
                 0.9941 
               
               
                   
                 1KG 
                 chr3: 126793536 
                 0.2453 
                 0.2552 
                 0.2102 
               
               
                   
                 1KG 
                 rs625761 
                 0.9263 
                 0.9461 
                 0.9174 
               
               
                   
                 1KG 
                 rs1540819 
                 0.984 
                 0.9735 
                 0.9848 
               
               
                   
                 1KG 
                 rs4073997 
                 0.568 
                 0.5764 
                 0.5644 
               
               
                   
                 1KG 
                 chr1: 59476907 
                 0.2253 
                 0.2317 
                 0.2453 
               
               
                   
                 HM3 
                 rs16965939 
                 0.6149 
                 0.6524 
                 0.5314 
               
               
                   
                 HM3 
                 rs1999930 
                 0.9913 
                 1.0007 
                 0.9517 
               
               
                   
                 HM3 
                 rs1789110 
                 0.9672 
                 0.9742 
                 0.9718 
               
               
                   
                 HM3 
                 rs10280782 
                 0.9687 
                 0.9696 
                 0.987 
               
               
                   
                 HM3 
                 rs1079982 
                 0.9093 
                 0.9236 
                 0.8932 
               
               
                   
                 HM3 
                 rs11854658 
                 0.9863 
                 0.985 
                 0.9979 
               
               
                   
                 HM3 
                 rs8076470 
                 0.9766 
                 0.9724 
                 0.9786 
               
               
                   
                 HM3 
                 rs8053796 
                 0.8103 
                 0.7844 
                 0.8621 
               
               
                   
                 HM3 
                 rs2037156 
                 0.9523 
                 0.95 
                 0.9508 
               
               
                   
                 HM3 
                 rs3760775 
                 0.8766 
                 0.8826 
                 0.8358 
               
               
                   
                 HM3 
                 rs9291737 
                 0.997 
                 0.9907 
                 0.988 
               
               
                   
                 HM3 
                 rs13094238 
                 0.4091 
                 0.3993 
                 0.4129 
               
               
                   
                 HM3 
                 rs2730613 
                 0.9713 
                 0.9617 
                 0.9645 
               
               
                   
                 HM3 
                 rs10103808 
                 0.9774 
                 0.9757 
                 0.9859 
               
               
                   
                 HM3 
                 rs7720497 
                 0.9138 
                 0.9361 
                 0.8956 
               
               
                   
                 HM3 
                 rs6531212 
                 0.9989 
                 0.9843 
                 0.9968 
               
               
                   
                 HM3 
                 rs8011890 
                 0.7579 
                 0.7236 
                 0.7932 
               
               
                   
                 HM3 
                 rs12926103 
                 0.9936 
                 0.9796 
                 1.0029 
               
               
                   
                 HM3 
                 rs16971055 
                 0.4484 
                 0.4448 
                 0.4839 
               
               
                   
                 HM3 
                 rs1912795 
                 0.9367 
                 0.931 
                 0.9339 
               
               
                   
                 HM3 
                 rs2127740 
                 0.9591 
                 0.9515 
                 0.9514 
               
               
                   
                 HM3 
                 rs17155281 
                 0.6319 
                 0.6427 
                 0.6212 
               
               
                   
                 HM3 
                 rs4256145 
                 1.0145 
                 1.0017 
                 0.9959 
               
               
                   
                 HM3 
                 rs6587759 
                 0.8617 
                 0.8415 
                 0.8666 
               
               
                   
                 HM3 
                 rs2052572 
                 0.9896 
                 0.9903 
                 0.981 
               
               
                   
                 HM3 
                 rs13278062 
                 0.6707 
                 0.6516 
                 0.7125 
               
               
                   
                 HM3 
                 rs722782 
                 1.0092 
                 1.019 
                 1.0014 
               
               
                   
                 HM3 
                 rs1867348 
                 0.9923 
                 0.9708 
                 1.0132 
               
               
                   
                 HM3 
                 rs9461856 
                 0.9815 
                 0.9915 
                 1.0084 
               
               
                   
                 HM3 
                 rs2270637 
                 0.9813 
                 0.9812 
                 1.0109 
               
               
                   
                 HM3 
                 rs2798832 
                 0.9125 
                 0.9197 
                 0.8881 
               
               
                   
                 HM3 
                 rs12632671 
                 0.8828 
                 0.8187 
                 0.8905 
               
               
                   
                 HM3 
                 rs9713311 
                 1.0066 
                 0.9994 
                 1.0069 
               
               
                   
                 HM3 
                 rs7626245 
                 0.9842 
                 0.999 
                 0.9526 
               
               
                   
                 HM3 
                 rs513683 
                 0.9822 
                 0.9615 
                 0.9855 
               
               
                   
                 HM3 
                 rs2376241 
                 0.9859 
                 0.9865 
                 1.0007 
               
               
                   
                 HM3 
                 rs251525 
                 0.9712 
                 0.9706 
                 0.9709 
               
               
                   
                 HM3 
                 rs1737478 
                 0.9964 
                 0.989 
                 1.0055 
               
               
                   
                 HM3 
                 rs7783337 
                 0.9116 
                 0.8804 
                 0.8931 
               
               
                   
                 HM3 
                 rs10225927 
                 1.0042 
                 0.9812 
                 1.0102 
               
               
                   
                 HM3 
                 rs164700 
                 0.8496 
                 0.8256 
                 0.8706 
               
               
                   
                 HM3 
                 rs10848645 
                 0.7953 
                 0.7845 
                 0.8209 
               
               
                   
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
             
           
               
                 TABLE 5 
               
               
                   
               
               
                 SNP 
                 CHR 
                 Gene 
                 POS 
                 EA 
                 OR_4vs5 
                 P_4vs5 
               
               
                   
               
             
             
               
                   
               
             
          
           
               
                 rs2032794 
                 5 
                 BC034940 
                 86468373 
                 T 
                 1.382687404 
                 9.41E−06 
               
               
                 rs7973431 
                 12 
                 BG203966 
                 92165329 
                 T 
                 1.368256087 
                 1.06E−05 
               
               
                 rs10207860 
                 2 
                 COL5A2 (alpha 2 type V 
                  1.9E+08 
                 T 
                 0.598765047 
                 8.56E−06 
               
               
                   
                   
                 collagen preprotein) 
               
               
                 rs11207037 
                 1 
                 DAB1 
                 57677552 
                 A 
                 1.351136378 
                 2.44E−05 
               
               
                 rs4771513 
                 13 
                 downstream AK058053 
                 1.05E+08 
                 T 
                 1.55674951 
                 8.13E−06 
               
               
                 rs2469875 
                 18 
                 downstream KC6 
                 36481096 
                 A 
                 0.769170975 
                 2.42E−05 
               
               
                 rs16924889 
                 10 
                 downstream KIAA1217 
                 24883792 
                 A 
                 1.694071834 
                 2.95E−05 
               
               
                 rs11876415 
                 18 
                 NETO1 
                 68641554 
                 T 
                 0.693451484 
                 8.51E−06 
               
               
                 rs5771717 
                 22 
                 FAM19A5 
                 47467676 
                 A 
                 0.627530502 
                 1.35E−06 
               
               
                 rs17639345 
                 4 
                 FSTL5 
                 1.63E+08 
                 A 
                 1.478590102 
                 1.81E−05 
               
               
                 rs3743105 
                 15 
                 GREM1 
                 30811243 
                 T 
                 0.7675482 
                 2.62E−05 
               
               
                 rs11716363 
                 3 
                 ITGA9 (integrin alpha 9 
                 37504640 
                 T 
                 1.443900309 
                 1.66E−05 
               
               
                   
                   
                 precursor) 
               
               
                 rs11736266 
                 4 
                 MARCH1 gene 
                 1.65E+08 
                 T 
                 1.302693443 
                 2.45E−05 
               
               
                 rs7317763 
                 13 
                 near SLITRK1 
                 83069357 
                 T 
                 1.310328671 
                 2.70E−05 
               
               
                 rs9475939 
                 6 
                 PRIM2 
                 57396889 
                 T 
                 2.48739008 
                 1.30E−05 
               
               
                 rs4755455 
                 11 
                 upstream QSER1 
                 32859894 
                 C 
                 1.579504199 
                 4.64E−07 
               
               
                 rs10815017 
                 9 
                 SLC1A1 
                 4536594 
                 T 
                 0.733460158 
                 6.75E−06 
               
               
                 rs1326005 
                 1 
                 upstream AK125078 
                 5303445 
                 A 
                 0.729567782 
                 3.42E−06 
               
               
                 rs7973032 
                 12 
                 upstream PPFIA2 
                 80847264 
                 A 
                 0.539440385 
                 1.67E−05 
               
               
                 rs958646 
                 20 
                 upstream PRNP 
                 4486243 
                 C 
                 0.640698687 
                 3.05E−05 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
             
               
               
               
               
               
               
             
               
               
               
               
               
               
             
               
               
               
               
               
               
               
             
           
               
                 TABLE 6 
               
               
                   
               
             
             
               
                 REF 
                 hg_18_BP 
                 OldSNP 
                 A1 
                 A2 
                 FRQ_A(2594) 
                 FRQ_U(4134) 
                 OR 
               
               
                   
               
               
                 1KG 
                 1:100166675 
                 chr1: 100166675 
                 T 
                 C 
                 0.0493 
                 0.0366 
                 1.3684 
               
               
                 1KG 
                 1:163986967 
                 chr1: 163986967 
                 T 
                 C 
                 0.052 
                 0.059 
                 0.7049 
               
               
                 1KG 
                 1:165795961 
                 rs1737478 
                 T 
                 C 
                 0.2451 
                 0.2262 
                 1.1357 
               
               
                 1KG 
                 1:185513773 
                 rs2453727 
                 T 
                 C 
                 0.4977 
                 0.492 
                 1.0017 
               
               
                 1KG 
                 1:194925860 
                 rs1061170 
                 T 
                 C 
                 0.3909 
                 0.6287 
                 0.3651 
               
               
                 1KG 
                 1:194963556 
                 rs1410996 
                 A 
                 G 
                 0.2004 
                 0.4206 
                 0.3207 
               
               
                 1KG 
                 1:205461564 
                 rs1367068 
                 A 
                 G 
                 0.8012 
                 0.774 
                 1.4018 
               
               
                 1KG 
                 1:205515927 
                 rs12040406 
                 T 
                 C 
                 0.9174 
                 0.906 
                 2.1921 
               
               
                 1KG 
                 1:227122574 
                 rs6685751 
                 A 
                 C 
                 0.4818 
                 0.4657 
                 1.1607 
               
               
                 1KG 
                 1:228362314 
                 rs4846914 
                 A 
                 G 
                 0.5938 
                 0.6043 
                 0.9609 
               
               
                 1KG 
                 1:247130153 
                 rs6587759 
                 A 
                 G 
                 0.0635 
                 0.051 
                 1.3373 
               
               
                 1KG 
                 1:31101812 
                 rs2491146 
                 A 
                 G 
                 0.3668 
                 0.3933 
                 0.8641 
               
               
                 1KG 
                 1:5303445 
                 rs1326005 
                 A 
                 G 
                 0.3841 
                 0.4049 
                 0.9191 
               
               
                 1KG 
                 1:57219300 
                 rs1418473 
                 A 
                 G 
                 0.0866 
                 0.072 
                 1.221 
               
               
                 1KG 
                 1:57677552 
                 rs11207037 
                 A 
                 G 
                 0.7507 
                 0.7569 
                 0.9771 
               
               
                 1KG 
                 1:79360392 
                 rs17408651 
                 T 
                 G 
                 0.1174 
                 0.1288 
                 0.8501 
               
               
                 1KG 
                 10:124204438 
                 rs10490924 
                 T 
                 G 
                 0.4144 
                 0.2058 
                 3.1865 
               
               
                 1KG 
                 10:19392088 
                 rs11596472 
                 A 
                 G 
                 0.9141 
                 0.9174 
                 0.869 
               
               
                 1KG 
                 10:24883792 
                 rs16924889 
                 A 
                 G 
                 0.0865 
                 0.0931 
                 0.9404 
               
               
                 1KG 
                 10:32036318 
                 rs2277252 
                 A 
                 G 
                 0.4765 
                 0.455 
                 1.1865 
               
               
                 1KG 
                 10:3945290 
                 rs11592003 
                 T 
                 C 
                 0.8623 
                 0.8385 
                 1.2203 
               
               
                 1KG 
                 10:56380194 
                 rs61856267 
                 A 
                 G 
                 0.8865 
                 0.9054 
                 0.7381 
               
               
                 1KG 
                 10:57479107 
                 chr10: 57479107 
                 A 
                 C 
                 0.1191 
                 0.1054 
                 1.1634 
               
               
                 1KG 
                 10:8226099 
                 rs2798832 
                 T 
                 C 
                 0.266 
                 0.2403 
                 1.166 
               
               
                 1KG 
                 10:88344492 
                 chr10: 88344492 
                 A 
                 C 
                 0.1597 
                 0.1406 
                 1.2144 
               
               
                 1KG 
                 10:88396729 
                 rs2803544 
                 A 
                 T 
                 0.1528 
                 0.1335 
                 1.2022 
               
               
                 1KG 
                 10:92382787 
                 rs7094579 
                 T 
                 C 
                 0.0451 
                 0.0568 
                 0.753 
               
               
                 1KG 
                 11:100149779 
                 rs625761 
                 A 
                 G 
                 0.7619 
                 0.7375 
                 1.1585 
               
               
                 1KG 
                 11:103362906 
                 rs12798294 
                 C 
                 G 
                 0.2689 
                 0.2959 
                 0.8706 
               
               
                 1KG 
                 11:104185708 
                 chr11: 104185708 
                 T 
                 G 
                 0.0478 
                 0.0463 
                 1.7253 
               
               
                 1KG 
                 11:116154127 
                 rs964184 
                 C 
                 G 
                 0.862 
                 0.8567 
                 1.0379 
               
               
                 1KG 
                 11:1762440 
                 rs55911157 
                 T 
                 C 
                 0.1489 
                 0.1731 
                 0.7781 
               
               
                 1KG 
                 11:1768072 
                 rs72850977 
                 A 
                 G 
                 0.148 
                 0.1723 
                 0.7792 
               
               
                 1KG 
                 11:32859894 
                 rs4755455 
                 C 
                 G 
                 0.1684 
                 0.1757 
                 0.9526 
               
               
                 1KG 
                 11:37597461 
                 rs10768315 
                 T 
                 C 
                 0.2642 
                 0.2971 
                 0.8472 
               
               
                 1KG 
                 11:61327359 
                 rs174547 
                 T 
                 C 
                 0.666 
                 0.6552 
                 1.05 
               
               
                 1KG 
                 11:73662041 
                 rs513683 
                 C 
                 G 
                 0.4409 
                 0.4611 
                 0.8991 
               
               
                 1KG 
                 12:108379551 
                 rs2338104 
                 C 
                 G 
                 0.4627 
                 0.4579 
                 1.046 
               
               
                 1KG 
                 12:11233234 
                 chr12: 11233234 
                 A 
                 T 
                 0.1532 
                 0.1392 
                 1.1565 
               
               
                 1KG 
                 12:114010367 
                 rs11067403 
                 T 
                 C 
                 0.6891 
                 0.658 
                 1.1478 
               
               
                 1KG 
                 12:123850701 
                 rs5888 
                 A 
                 G 
                 0.4889 
                 0.4859 
                 0.998 
               
               
                 1KG 
                 12:19878442 
                 rs1492116 
                 T 
                 C 
                 0.79 
                 0.7665 
                 1.1876 
               
               
                 1KG 
                 12:2290505 
                 rs10848645 
                 A 
                 G 
                 0.571 
                 0.6031 
                 0.8399 
               
               
                 1KG 
                 12:45893566 
                 rs11183802 
                 A 
                 G 
                 0.0774 
                 0.0708 
                 1.3253 
               
               
                 1KG 
                 12:50881293 
                 rs7958529 
                 C 
                 G 
                 0.6738 
                 0.6506 
                 1.1835 
               
               
                 1KG 
                 12:80847264 
                 rs7973032 
                 A 
                 G 
                 0.9291 
                 0.9315 
                 1.0429 
               
               
                 1KG 
                 12:92165329 
                 rs7973431 
                 T 
                 C 
                 0.3164 
                 0.3168 
                 1.0087 
               
               
                 1KG 
                 13:105365389 
                 rs4771513 
                 T 
                 C 
                 0.8738 
                 0.8725 
                 1.053 
               
               
                 1KG 
                 13:30736688 
                 rs1912795 
                 A 
                 G 
                 0.4579 
                 0.4329 
                 1.1392 
               
               
                 1KG 
                 13:78960018 
                 rs17071512 
                 T 
                 C 
                 0.9039 
                 0.8967 
                 1.2417 
               
               
                 1KG 
                 13:83069357 
                 rs7317763 
                 T 
                 C 
                 0.4613 
                 0.4456 
                 1.0722 
               
               
                 1KG 
                 14:95216646 
                 rs8011890 
                 A 
                 C 
                 0.099 
                 0.0828 
                 1.4427 
               
               
                 1KG 
                 15:30811243 
                 rs3743105 
                 T 
                 C 
                 0.4142 
                 0.4211 
                 0.9607 
               
               
                 1KG 
                 15:35201758 
                 chr15: 35201758 
                 T 
                 G 
                 0.1508 
                 0.1344 
                 1.3375 
               
               
                 1KG 
                 15:35992085 
                 rs16965939 
                 T 
                 C 
                 0.0907 
                 0.1081 
                 0.6687 
               
               
                 1KG 
                 15:40375218 
                 rs12908430 
                 A 
                 G 
                 0.0812 
                 0.0899 
                 0.6083 
               
               
                 1KG 
                 15:47957127 
                 chr15: 47957127 
                 T 
                 G 
                 0.0105 
                 0.0115 
                 0.1281 
               
               
                 1KG 
                 15:56465804 
                 rs10468017 
                 T 
                 C 
                 0.2564 
                 0.2874 
                 0.8324 
               
               
                 1KG 
                 15:56475172 
                 rs493258 
                 T 
                 C 
                 0.4318 
                 0.4714 
                 0.8481 
               
               
                 1KG 
                 15:59828725 
                 rs11854497 
                 A 
                 G 
                 0.1036 
                 0.1139 
                 0.825 
               
               
                 1KG 
                 15:87312556 
                 rs11854658 
                 A 
                 G 
                 0.6764 
                 0.6461 
                 1.1633 
               
               
                 1KG 
                 15:87314645 
                 rs11856826 
                 T 
                 C 
                 0.6577 
                 0.6267 
                 1.1722 
               
               
                 1KG 
                 16:11814579 
                 rs2024393 
                 T 
                 C 
                 0.16 
                 0.1583 
                 1.0619 
               
               
                 1KG 
                 16:17310751 
                 chr16: 17310751 
                 A 
                 G 
                 0.9164 
                 0.8991 
                 1.3105 
               
               
                 1KG 
                 16:23091095 
                 rs4967980 
                 T 
                 C 
                 0.7435 
                 0.7747 
                 0.8305 
               
               
                 1KG 
                 16:55550825 
                 rs3764261 
                 A 
                 C 
                 0.36 
                 0.3277 
                 1.1631 
               
               
                 1KG 
                 16:66459571 
                 rs2271293 
                 A 
                 G 
                 0.1249 
                 0.1157 
                 1.0897 
               
               
                 1KG 
                 16:72289810 
                 rs2127740 
                 A 
                 G 
                 0.1392 
                 0.1138 
                 1.2894 
               
               
                 1KG 
                 16:74921678 
                 rs8053796 
                 T 
                 C 
                 0.2789 
                 0.2638 
                 1.1928 
               
               
                 1KG 
                 16:74929641 
                 rs6564324 
                 A 
                 G 
                 0.7163 
                 0.7325 
                 0.8354 
               
               
                 1KG 
                 16:84929276 
                 rs12926103 
                 A 
                 G 
                 0.0664 
                 0.0573 
                 1.4308 
               
               
                 1KG 
                 16:85846518 
                 rs3748391 
                 T 
                 G 
                 0.518 
                 0.5459 
                 0.8754 
               
               
                 1KG 
                 17:45980827 
                 rs8076470 
                 T 
                 C 
                 0.4062 
                 0.3844 
                 1.1472 
               
               
                 1KG 
                 17:72483712 
                 chr17: 72483712 
                 A 
                 G 
                 0.9454 
                 0.9428 
                 1.2989 
               
               
                 1KG 
                 17:73838135 
                 rs16971055 
                 A 
                 G 
                 0.096 
                 0.0876 
                 1.3213 
               
               
                 1KG 
                 17:77136846 
                 rs4073997 
                 C 
                 G 
                 0.212 
                 0.2118 
                 1.1002 
               
               
                 1KG 
                 18:34111545 
                 rs8091635 
                 T 
                 C 
                 0.3871 
                 0.3485 
                 1.1987 
               
               
                 1KG 
                 18:34125717 
                 rs17628762 
                 A 
                 C 
                 0.3824 
                 0.3426 
                 1.188 
               
               
                 1KG 
                 18:36481096 
                 rs2469875 
                 A 
                 G 
                 0.5168 
                 0.5163 
                 1.0045 
               
               
                 1KG 
                 18:45421212 
                 rs4939883 
                 T 
                 C 
                 0.1743 
                 0.1714 
                 1.0146 
               
               
                 1KG 
                 18:53934507 
                 rs529478 
                 A 
                 T 
                 0.5166 
                 0.4897 
                 1.2005 
               
               
                 1KG 
                 18:68641554 
                 rs11876415 
                 T 
                 C 
                 0.6298 
                 0.6297 
                 1.0636 
               
               
                 1KG 
                 18:72988032 
                 rs1789110 
                 A 
                 C 
                 0.5878 
                 0.6251 
                 0.8321 
               
               
                 1KG 
                 19:36639376 
                 rs2052572 
                 A 
                 G 
                 0.3482 
                 0.3141 
                 1.1729 
               
               
                 1KG 
                 19:5792356 
                 rs3760775 
                 T 
                 G 
                 0.055 
                 0.0679 
                 0.7243 
               
               
                 HM2 
                 19:59425996 
                 rs7260457 
                 C 
                 G 
                 0.3679 
                 0.3736 
                 0.7477 
               
               
                 1KG 
                 19:6669387 
                 rs2230199 
                 C 
                 G 
                 0.2439 
                 0.1926 
                 1.6842 
               
               
                 1KG 
                 19:8375738 
                 rs2967605 
                 T 
                 C 
                 0.1811 
                 0.1762 
                 1.0509 
               
               
                 1KG 
                 2:124751486 
                 rs9308649 
                 A 
                 T 
                 0.8153 
                 0.7908 
                 1.198 
               
               
                 1KG 
                 2:180796214 
                 chr2: 180796214 
                 A 
                 C 
                 0.1728 
                 0.1957 
                 0.8419 
               
               
                 1KG 
                 2:189854831 
                 rs10207860 
                 T 
                 C 
                 0.0682 
                 0.0719 
                 0.9 
               
               
                 1KG 
                 2:20201501 
                 rs6531212 
                 T 
                 C 
                 0.3177 
                 0.3514 
                 0.8491 
               
               
                 1KG 
                 2:44132778 
                 chr2: 44132778 
                 A 
                 G 
                 0.9374 
                 0.9244 
                 1.4611 
               
               
                 1KG 
                 2:71597893 
                 rs13402171 
                 T 
                 C 
                 0.0904 
                 0.091 
                 1.0004 
               
               
                 1KG 
                 2:76232489 
                 rs1851808 
                 A 
                 G 
                 0.6074 
                 0.6375 
                 0.8696 
               
               
                 1KG 
                 20:42475778 
                 rs1800961 
                 T 
                 C 
                 0.0264 
                 0.0314 
                 0.8286 
               
               
                 1KG 
                 20:44009909 
                 rs7679 
                 T 
                 C 
                 0.8196 
                 0.8135 
                 1.0601 
               
               
                 1KG 
                 20:4486243 
                 rs958646 
                 C 
                 G 
                 0.0838 
                 0.087 
                 0.9867 
               
               
                 1KG 
                 20:56979160 
                 rs235195 
                 A 
                 G 
                 0.1336 
                 0.1251 
                 1.364 
               
               
                 HM2 
                 22:31414511 
                 rs9621532 
                 A 
                 C 
                 0.9634 
                 0.9488 
                 1.3892 
               
               
                 1KG 
                 22:36259705 
                 rs1079982 
                 T 
                 G 
                 0.0471 
                 0.065 
                 0.7054 
               
               
                 1KG 
                 22:43172593 
                 rs135912 
                 A 
                 G 
                 0.7348 
                 0.7265 
                 1.0507 
               
               
                 1KG 
                 22:47467676 
                 rs5771717 
                 A 
                 G 
                 0.1034 
                 0.1002 
                 1.1586 
               
               
                 1KG 
                 3:100878962 
                 rs13095226 
                 T 
                 C 
                 0.8772 
                 0.896 
                 0.8167 
               
               
                 1KG 
                 3:101053451 
                 rs7626245 
                 C 
                 G 
                 0.0904 
                 0.0727 
                 1.3399 
               
               
                 1KG 
                 3:118210505 
                 rs1540819 
                 T 
                 C 
                 0.4652 
                 0.4345 
                 1.1303 
               
               
                 1KG 
                 3:119674993 
                 rs12637095 
                 A 
                 T 
                 0.8045 
                 0.7797 
                 1.1955 
               
               
                 1KG 
                 3:119681130 
                 rs1915098 
                 A 
                 G 
                 0.1414 
                 0.1655 
                 0.7983 
               
               
                 1KG 
                 3:120558458 
                 rs9713311 
                 T 
                 C 
                 0.5952 
                 0.6235 
                 0.8814 
               
               
                 1KG 
                 3:130591125 
                 rs12632105 
                 C 
                 G 
                 0.1669 
                 0.1695 
                 0.9737 
               
               
                 1KG 
                 3:154434339 
                 rs16822447 
                 A 
                 T 
                 0.8637 
                 0.8442 
                 1.178 
               
               
                 1KG 
                 3:156261403 
                 rs13094238 
                 T 
                 C 
                 0.8604 
                 0.8539 
                 1.3416 
               
               
                 1KG 
                 3:163192835 
                 rs4256145 
                 A 
                 G 
                 0.6945 
                 0.6619 
                 1.185 
               
               
                 1KG 
                 3:37504640 
                 rs11716363 
                 T 
                 C 
                 0.1892 
                 0.179 
                 1.0861 
               
               
                 1KG 
                 3:53233464 
                 rs12632671 
                 A 
                 G 
                 0.0676 
                 0.0568 
                 1.4031 
               
               
                 1KG 
                 3:71584585 
                 rs2135548 
                 A 
                 G 
                 0.7302 
                 0.7598 
                 0.8518 
               
               
                 1KG 
                 4:110878516 
                 rs10033900 
                 T 
                 C 
                 0.5205 
                 0.463 
                 1.3144 
               
               
                 1KG 
                 4:128495772 
                 rs1443179 
                 T 
                 G 
                 0.0388 
                 0.0348 
                 1.7594 
               
               
                 1KG 
                 4:162971300 
                 rs17639345 
                 A 
                 G 
                 0.1539 
                 0.1466 
                 1.0405 
               
               
                 1KG 
                 4:165142286 
                 rs11736266 
                 T 
                 C 
                 0.478 
                 0.4827 
                 0.951 
               
               
                 1KG 
                 4:182181154 
                 rs9997006 
                 T 
                 G 
                 0.3841 
                 0.3654 
                 1.2106 
               
               
                 1KG 
                 4:23188024 
                 chr4: 23188024 
                 A 
                 T 
                 0.0345 
                 0.0389 
                 0.491 
               
               
                 1KG 
                 4:36840346 
                 rs2376241 
                 T 
                 G 
                 0.2687 
                 0.2423 
                 1.148 
               
               
                 1KG 
                 4:86877248 
                 rs28621471 
                 A 
                 G 
                 0.2253 
                 0.2481 
                 0.8532 
               
               
                 1KG 
                 5:106936632 
                 rs164700 
                 A 
                 C 
                 0.1655 
                 0.142 
                 1.2085 
               
               
                 1KG 
                 5:113645446 
                 chr5: 113645446 
                 C 
                 G 
                 0.8488 
                 0.868 
                 0.8275 
               
               
                 1KG 
                 5:149749881 
                 chr5: 149749881 
                 C 
                 G 
                 0.0812 
                 0.0713 
                 1.2083 
               
               
                 1KG 
                 5:165133520 
                 chr5: 165133520 
                 T 
                 C 
                 0.8269 
                 0.8052 
                 1.1637 
               
               
                 1KG 
                 5:21309600 
                 rs2883171 
                 T 
                 G 
                 0.863 
                 0.884 
                 0.7562 
               
               
                 1KG 
                 5:26212150 
                 chr5: 26212150 
                 T 
                 C 
                 0.9433 
                 0.9267 
                 1.4173 
               
               
                 1KG 
                 5:52621268 
                 rs251525 
                 A 
                 G 
                 0.6677 
                 0.6899 
                 0.8717 
               
               
                 1KG 
                 5:5291813 
                 rs7720497 
                 C 
                 G 
                 0.932 
                 0.9454 
                 0.7282 
               
               
                 1KG 
                 5:61112540 
                 rs9291737 
                 A 
                 T 
                 0.6143 
                 0.5789 
                 1.1581 
               
               
                 1KG 
                 5:64292165 
                 rs10067691 
                 A 
                 G 
                 0.0525 
                 0.0594 
                 0.694 
               
               
                 1KG 
                 5:74385314 
                 rs12520598 
                 T 
                 C 
                 0.0438 
                 0.0509 
                 0.7993 
               
               
                 1KG 
                 5:86468373 
                 rs2032794 
                 T 
                 C 
                 0.7796 
                 0.7892 
                 0.9488 
               
               
                 1KG 
                 6:109470664 
                 rs13192030 
                 A 
                 T 
                 0.9634 
                 0.9643 
                 1.3742 
               
               
                 1KG 
                 6:116493827 
                 rs1999930 
                 T 
                 C 
                 0.2595 
                 0.3044 
                 0.8068 
               
               
                 1KG 
                 6:116529937 
                 rs509859 
                 T 
                 G 
                 0.3742 
                 0.4133 
                 0.8508 
               
               
                 1KG 
                 6:116568331 
                 rs12204816 
                 T 
                 C 
                 0.1906 
                 0.224 
                 0.7488 
               
               
                 1KG 
                 6:116596243 
                 rs12196141 
                 A 
                 G 
                 0.7543 
                 0.7128 
                 1.254 
               
               
                 1KG 
                 6:1324870 
                 rs9328048 
                 T 
                 C 
                 0.3673 
                 0.395 
                 0.846 
               
               
                 1KG 
                 6:132523980 
                 rs728371 
                 A 
                 G 
                 0.3437 
                 0.3145 
                 1.1821 
               
               
                 1KG 
                 6:160376153 
                 rs1867348 
                 T 
                 C 
                 0.0986 
                 0.0801 
                 1.2525 
               
               
                 1KG 
                 6:162467903 
                 chr6: 162467903 
                 A 
                 G 
                 0.0781 
                 0.09 
                 0.8001 
               
               
                 1KG 
                 6:31277268 
                 rs9366769 
                 T 
                 C 
                 0.8016 
                 0.7695 
                 1.2329 
               
               
                 1KG 
                 6:32011783 
                 rs9332739 
                 C 
                 G 
                 0.0231 
                 0.0447 
                 0.4463 
               
               
                 1KG 
                 6:32022159 
                 rs641153 
                 A 
                 G 
                 0.0528 
                 0.101 
                 0.461 
               
               
                 1KG 
                 6:33503177 
                 rs9461856 
                 A 
                 G 
                 0.4878 
                 0.5204 
                 0.8641 
               
               
                 1KG 
                 6:43936560 
                 rs4711751 
                 T 
                 C 
                 0.5352 
                 0.5044 
                 1.2081 
               
               
                 1KG 
                 6:55456674 
                 rs4260755 
                 A 
                 C 
                 0.3862 
                 0.3512 
                 1.152 
               
               
                 1KG 
                 6:57396889 
                 rs9475939 
                 T 
                 C 
                 0.9717 
                 0.9716 
                 0.7707 
               
               
                 1KG 
                 6:7063989 
                 rs11755724 
                 A 
                 G 
                 0.3424 
                 0.3723 
                 0.878 
               
               
                 1KG 
                 6:7152544 
                 rs1360751 
                 A 
                 C 
                 0.5508 
                 0.5208 
                 1.1507 
               
               
                 1KG 
                 6:93573222 
                 rs2037156 
                 A 
                 G 
                 0.7857 
                 0.8074 
                 0.8562 
               
               
                 HM2 
                 7:14123511 
                 rs7783337 
                 A 
                 G 
                 0.8481 
                 0.8625 
                 0.8475 
               
               
                 1KG 
                 7:23550807 
                 rs10280782 
                 A 
                 G 
                 0.8768 
                 0.8487 
                 1.3025 
               
               
                 1KG 
                 7:27475356 
                 rs17155281 
                 T 
                 C 
                 0.724 
                 0.7083 
                 1.1382 
               
               
                 1KG 
                 7:35595154 
                 rs343718 
                 A 
                 C 
                 0.2884 
                 0.3029 
                 0.9357 
               
               
                 1KG 
                 7:43880667 
                 rs2730613 
                 A 
                 C 
                 0.6656 
                 0.6475 
                 1.1333 
               
               
                 1KG 
                 7:54736904 
                 rs10225927 
                 A 
                 G 
                 0.7841 
                 0.8095 
                 0.847 
               
               
                 1KG 
                 7:86076557 
                 rs1358395 
                 A 
                 G 
                 0.2901 
                 0.3185 
                 0.8507 
               
               
                 1KG 
                 8:123521501 
                 rs4282579 
                 A 
                 G 
                 0.6556 
                 0.6888 
                 0.8571 
               
               
                 1KG 
                 8:128550166 
                 rs10089310 
                 A 
                 T 
                 0.1149 
                 0.0961 
                 1.2349 
               
               
                 1KG 
                 8:136110326 
                 rs13253938 
                 A 
                 G 
                 0.4722 
                 0.4365 
                 1.1837 
               
               
                 1KG 
                 8:13715406 
                 rs1384044 
                 T 
                 C 
                 0.5042 
                 0.5311 
                 0.8777 
               
               
                 1KG 
                 8:139212254 
                 rs10103808 
                 A 
                 T 
                 0.8852 
                 0.9095 
                 0.754 
               
               
                 1KG 
                 8:14247492 
                 rs10503493 
                 A 
                 C 
                 0.0425 
                 0.055 
                 0.7705 
               
               
                 1KG 
                 8:19888502 
                 rs12678919 
                 A 
                 G 
                 0.9011 
                 0.899 
                 1.0259 
               
               
                 1KG 
                 8:20081107 
                 rs2270637 
                 C 
                 G 
                 0.8272 
                 0.8001 
                 1.222 
               
               
                 1KG 
                 8:23138916 
                 rs13278062 
                 T 
                 G 
                 0.5369 
                 0.5138 
                 1.1804 
               
               
                 1KG 
                 8:506479 
                 rs722782 
                 A 
                 C 
                 0.0841 
                 0.1055 
                 0.7698 
               
               
                 HM2 
                 8:96819457 
                 rs6982567 
                 T 
                 C 
                 0.2077 
                 0.1912 
                 1.1905 
               
               
                 1KG 
                 9:106704122 
                 rs1883025 
                 T 
                 C 
                 0.2564 
                 0.2784 
                 0.8697 
               
               
                 1KG 
                 9:114121319 
                 rs10739343 
                 A 
                 G 
                 0.2015 
                 0.2256 
                 0.8504 
               
               
                 1KG 
                 9:15279578 
                 rs471364 
                 T 
                 C 
                 0.8882 
                 0.8857 
                 1.0291 
               
               
                 1KG 
                 9:4536594 
                 rs10815017 
                 T 
                 C 
                 0.2991 
                 0.3153 
                 0.9327 
               
               
                   
               
             
          
           
               
                 REF 
                 hg_18_BP 
                 OldSNP 
                 SE 
                 P 
                 EA 
                 Z 
               
               
                   
               
               
                 1KG 
                 1:100166675 
                 chr1: 100166675 
                 0.0913 
                 0.0005929 
                 T 
                 3.434841729 
               
               
                 1KG 
                 1:163986967 
                 chr1: 163986967 
                 0.1261 
                 0.00555 
                 T 
                 −2.773246868 
               
               
                 1KG 
                 1:165795961 
                 rs1737478 
                 0.0437 
                 0.003573 
                 T 
                 2.913588976 
               
               
                 1KG 
                 1:185513773 
                 rs2453727 
                 0.0371 
                 0.964 
                 T 
                 0.045134628 
               
               
                 1KG 
                 1:194925860 
                 rs1061170 
                 0.0403 
                 5.638E−138 
                 C 
                 25.00323274 
               
               
                 1KG 
                 1:194963556 
                 rs1410996 
                 0.0461 
                 2.147E−134 
                 G 
                 24.67181558 
               
               
                 1KG 
                 1:205461564 
                 rs1367068 
                 0.0658 
                 2.796E−07 
                 G 
                 −5.136703203 
               
               
                 1KG 
                 1:205515927 
                 rs12040406 
                 0.1528 
                 2.786E−07 
                 C 
                 −5.137376796 
               
               
                 1KG 
                 1:227122574 
                 rs6685751 
                 0.0507 
                 0.003299 
                 A 
                 2.9384104 
               
               
                 1KG 
                 1:228362314 
                 rs4846914 
                 0.038 
                 0.2946 
                 G 
                 1.048083799 
               
               
                 1KG 
                 1:247130153 
                 rs6587759 
                 0.0817 
                 0.0003756 
                 A 
                 3.556659831 
               
               
                 1KG 
                 1:31101812 
                 rs2491146 
                 0.0409 
                 0.000358 
                 A 
                 −3.569253417 
               
               
                 1KG 
                 1:5303445 
                 rs1326005 
                 0.0404 
                 0.03688 
                 A 
                 −2.087089998 
               
               
                 1KG 
                 1:57219300 
                 rs1418473 
                 0.0714 
                 0.005179 
                 A 
                 2.795684072 
               
               
                 1KG 
                 1:57677552 
                 rs11207037 
                 0.0436 
                 0.5953 
                 G 
                 0.531171414 
               
               
                 1KG 
                 1:79360392 
                 rs17408651 
                 0.0666 
                 0.01478 
                 T 
                 −2.437725319 
               
               
                 1KG 
                 10:124204438 
                 rs10490924 
                 0.0453 
                  1.21E−144 
                 T 
                 25.60903658 
               
               
                 1KG 
                 10:19392088 
                 rs11596472 
                 0.1042 
                 0.1779 
                 G 
                 1.34724916 
               
               
                 1KG 
                 10:24883792 
                 rs16924889 
                 0.0679 
                 0.3655 
                 A 
                 −0.904934667 
               
               
                 1KG 
                 10:32036318 
                 rs2277252 
                 0.0437 
                 0.00008953 
                 A 
                 3.917343855 
               
               
                 1KG 
                 10:3945290 
                 rs11592003 
                 0.0533 
                 0.0001869 
                 C 
                 −3.736095111 
               
               
                 1KG 
                 10:56380194 
                 rs61856267 
                 0.0745 
                 0.00004618 
                 G 
                 4.074163657 
               
               
                 1KG 
                 10:57479107 
                 chr10: 57479107 
                 0.0593 
                 0.01073 
                 A 
                 2.551371123 
               
               
                 1KG 
                 10:8226099 
                 rs2798832 
                 0.0444 
                 0.0005466 
                 T 
                 3.456814979 
               
               
                 1KG 
                 10:88344492 
                 chr10: 88344492 
                 0.0534 
                 0.0002725 
                 A 
                 3.640130402 
               
               
                 1KG 
                 10:88396729 
                 rs2803544 
                 0.0536 
                 0.000592 
                 A 
                 3.435253392 
               
               
                 1KG 
                 10:92382787 
                 rs7094579 
                 0.0857 
                 0.0009303 
                 T 
                 −3.310799016 
               
               
                 1KG 
                 11:100149779 
                 rs625761 
                 0.0444 
                 0.0009244 
                 G 
                 −3.312579045 
               
               
                 1KG 
                 11:103362906 
                 rs12798294 
                 0.0421 
                 0.0009907 
                 C 
                 −3.293154553 
               
               
                 1KG 
                 11:104185708 
                 chr11: 104185708 
                 0.2201 
                 0.01322 
                 T 
                 2.477787107 
               
               
                 1KG 
                 11:116154127 
                 rs964184 
                 0.0538 
                 0.4885 
                 G 
                 −0.692696557 
               
               
                 1KG 
                 11:1762440 
                 rs55911157 
                 0.0567 
                 0.000009621 
                 T 
                 −4.425520544 
               
               
                 1KG 
                 11:1768072 
                 rs72850977 
                 0.0562 
                 0.000008946 
                 A 
                 −4.441196633 
               
               
                 1KG 
                 11:32859894 
                 rs4755455 
                 0.0498 
                 0.3297 
                 C 
                 −0.974718326 
               
               
                 1KG 
                 11:37597461 
                 rs10768315 
                 0.0417 
                 0.00007111 
                 T 
                 −3.972540972 
               
               
                 1KG 
                 11:61327359 
                 rs174547 
                 0.039 
                 0.2107 
                 C 
                 −1.251642941 
               
               
                 1KG 
                 11:73662041 
                 rs513683 
                 0.0386 
                 0.005903 
                 C 
                 −2.753121412 
               
               
                 1KG 
                 12:108379551 
                 rs2338104 
                 0.0372 
                 0.2264 
                 G 
                 −1.209684447 
               
               
                 1KG 
                 12:11233234 
                 chr12: 11233234 
                 0.0716 
                 0.04241 
                 A 
                 2.02947434 
               
               
                 1KG 
                 12:114010367 
                 rs11067403 
                 0.0396 
                 0.0005053 
                 C 
                 −3.477930989 
               
               
                 1KG 
                 12:123850701 
                 rs5888 
                 0.0387 
                 0.9593 
                 G 
                 0.051032027 
               
               
                 1KG 
                 12:19878442 
                 rs1492116 
                 0.0449 
                 0.00013 
                 C 
                 −3.826458602 
               
               
                 1KG 
                 12:2290505 
                 rs10848645 
                 0.0435 
                 0.00006143 
                 G 
                 4.007249345 
               
               
                 1KG 
                 12:45893566 
                 rs11183802 
                 0.0906 
                 0.001883 
                 A 
                 3.108091123 
               
               
                 1KG 
                 12:50881293 
                 rs7958529 
                 0.044 
                 0.0001293 
                 G 
                 −3.827788094 
               
               
                 1KG 
                 12:80847264 
                 rs7973032 
                 0.075 
                 0.5758 
                 G 
                 −0.559530092 
               
               
                 1KG 
                 12:92165329 
                 rs7973431 
                 0.0412 
                 0.8331 
                 T 
                 0.21072739 
               
               
                 1KG 
                 13:105365389 
                 rs4771513 
                 0.0594 
                 0.3845 
                 C 
                 −0.869634825 
               
               
                 1KG 
                 13:30736688 
                 rs1912795 
                 0.0379 
                 0.0005884 
                 A 
                 3.436905894 
               
               
                 1KG 
                 13:78960018 
                 rs17071512 
                 0.0726 
                 0.002856 
                 C 
                 −2.982826333 
               
               
                 1KG 
                 13:83069357 
                 rs7317763 
                 0.0378 
                 0.06489 
                 T 
                 1.846015189 
               
               
                 1KG 
                 14:95216646 
                 rs8011890 
                 0.0881 
                 0.00003215 
                 A 
                 4.157677112 
               
               
                 1KG 
                 15:30811243 
                 rs3743105 
                 0.0381 
                 0.293 
                 T 
                 −1.051563198 
               
               
                 1KG 
                 15:35201758 
                 chr15: 35201758 
                 0.069 
                 0.00002486 
                 T 
                 4.216066935 
               
               
                 1KG 
                 15:35992085 
                 rs16965939 
                 0.0934 
                 0.00001622 
                 T 
                 −4.311432897 
               
               
                 1KG 
                 15:40375218 
                 rs12908430 
                 0.1414 
                 0.0004389 
                 A 
                 −3.515516189 
               
               
                 1KG 
                 15:47957127 
                 chr15: 47957127 
                 0.9639 
                 0.03299 
                 T 
                 −2.132204971 
               
               
                 1KG 
                 15:56465804 
                 rs10468017 
                 0.045 
                 0.00004595 
                 T 
                 −4.075325644 
               
               
                 1KG 
                 15:56475172 
                 rs493258 
                 0.0376 
                 0.00001198 
                 C 
                 4.377951501 
               
               
                 1KG 
                 15:59828725 
                 rs11854497 
                 0.0618 
                 0.001868 
                 A 
                 −3.110453982 
               
               
                 1KG 
                 15:87312556 
                 rs11854658 
                 0.0391 
                 0.0001108 
                 G 
                 −3.865636189 
               
               
                 1KG 
                 15:87314645 
                 rs11856826 
                 0.0406 
                 0.00009204 
                 C 
                 −3.910671187 
               
               
                 1KG 
                 16:11814579 
                 rs2024393 
                 0.0665 
                 0.3666 
                 T 
                 0.902860381 
               
               
                 1KG 
                 16:17310751 
                 chr16: 17310751 
                 0.0695 
                 0.0001012 
                 G 
                 −3.887696628 
               
               
                 1KG 
                 16:23091095 
                 rs4967980 
                 0.045 
                 0.0000362 
                 C 
                 4.130484184 
               
               
                 1KG 
                 16:55550825 
                 rs3764261 
                 0.0392 
                 0.0001162 
                 A 
                 3.85400757 
               
               
                 1KG 
                 16:66459571 
                 rs2271293 
                 0.0574 
                 0.1345 
                 A 
                 1.496589899 
               
               
                 1KG 
                 16:72289810 
                 rs2127740 
                 0.057 
                 0.000008169 
                 A 
                 4.460706246 
               
               
                 1KG 
                 16:74921678 
                 rs8053796 
                 0.048 
                 0.0002414 
                 T 
                 3.671215171 
               
               
                 1KG 
                 16:74929641 
                 rs6564324 
                 0.0481 
                 0.0001849 
                 G 
                 3.738801021 
               
               
                 1KG 
                 16:84929276 
                 rs12926103 
                 0.0864 
                 0.00003384 
                 A 
                 4.145955195 
               
               
                 1KG 
                 16:85846518 
                 rs3748391 
                 0.037 
                 0.0003254 
                 T 
                 −3.594191857 
               
               
                 1KG 
                 17:45980827 
                 rs8076470 
                 0.0392 
                 0.0004619 
                 T 
                 3.501930552 
               
               
                 1KG 
                 17:72483712 
                 chr17: 72483712 
                 0.1484 
                 0.07803 
                 G 
                 −1.762232637 
               
               
                 1KG 
                 17:73838135 
                 rs16971055 
                 0.0998 
                 0.00524 
                 A 
                 2.791897205 
               
               
                 1KG 
                 17:77136846 
                 rs4073997 
                 0.1728 
                 0.5804 
                 C 
                 0.552800538 
               
               
                 1KG 
                 18:34111545 
                 rs8091635 
                 0.0401 
                 0.000006243 
                 T 
                 4.517988076 
               
               
                 1KG 
                 18:34125717 
                 rs17628762 
                 0.0388 
                 0.000008979 
                 A 
                 4.440404368 
               
               
                 1KG 
                 18:36481096 
                 rs2469875 
                 0.037 
                 0.9027 
                 G 
                 −0.122251299 
               
               
                 1KG 
                 18:45421212 
                 rs4939883 
                 0.0486 
                 0.7654 
                 T 
                 0.298397234 
               
               
                 1KG 
                 18:53934507 
                 rs529478 
                 0.0449 
                 0.00004656 
                 T 
                 −4.072255823 
               
               
                 1KG 
                 18:68641554 
                 rs11876415 
                 0.0486 
                 0.205 
                 C 
                 −1.267434417 
               
               
                 1KG 
                 18:72988032 
                 rs1789110 
                 0.0394 
                 0.000003171 
                 C 
                 4.659421045 
               
               
                 1KG 
                 19:36639376 
                 rs2052572 
                 0.0409 
                 0.00009603 
                 A 
                 3.9004098 
               
               
                 1KG 
                 19:5792356 
                 rs3760775 
                 0.0866 
                 0.0001966 
                 T 
                 −3.723345742 
               
               
                 HM2 
                 19:59425996 
                 rs7260457 
                 0.1028 
                 0.004664 
                 C 
                 −2.829368242 
               
               
                 1KG 
                 19:6669387 
                 rs2230199 
                 0.0592 
                 1.357E−18 
                 C 
                 8.800919225 
               
               
                 1KG 
                 19:8375738 
                 rs2967605 
                 0.0505 
                 0.3256 
                 T 
                 0.9830151.14 
               
               
                 1KG 
                 2:124751486 
                 rs9308649 
                 0.0476 
                 0.0001473 
                 T 
                 −3.795577787 
               
               
                 1KG 
                 2:180796214 
                 chr2: 180796214 
                 0.0503 
                 0.0006251 
                 A 
                 −3.420483185 
               
               
                 1KG 
                 2:189854831 
                 rs10207860 
                 0.0765 
                 0.1687 
                 T 
                 −1.376392981 
               
               
                 1KG 
                 2:20201501 
                 rs6531212 
                 0.0392 
                 0.00003021 
                 T 
                 −4.171877535 
               
               
                 1KG 
                 2:44132778 
                 chr2:44132778 
                 0.1037 
                 0.0002569 
                 G 
                 −3.655281432 
               
               
                 1KG 
                 2:71597893 
                 rs13402171 
                 0.064 
                 0.9956 
                 T 
                 0.00551461 
               
               
                 1KG 
                 2:76232489 
                 rs1851808 
                 0.039 
                 0.0003417 
                 G 
                 3.581444295 
               
               
                 1KG 
                 20:42475778 
                 rs1800961 
                 0.112 
                 0.09321 
                 T 
                 −1.678702697 
               
               
                 1KG 
                 20:44009909 
                 rs7679 
                 0.0483 
                 0.227 
                 C 
                 −1.20812288 
               
               
                 1KG 
                 20:4486243 
                 rs958646 
                 0.0671 
                 0.8419 
                 C 
                 −0.199463746 
               
               
                 1KG 
                 20:56979160 
                 rs235195 
                 0.104 
                 0.002827 
                 A 
                 2.985948769 
               
               
                 HM2 
                 22:31414511 
                 rs9621532 
                 0.0924 
                 0.0003732 
                 C 
                 −3.558344238 
               
               
                 1KG 
                 22:36259705 
                 rs1079982 
                 0.0923 
                 0.0001557 
                 T 
                 −3.781797499 
               
               
                 1KG 
                 22:43172593 
                 rs135912 
                 0.0492 
                 0.3149 
                 G 
                 −1.004993458 
               
               
                 1KG 
                 22:47467676 
                 rs5771717 
                 0.0896 
                 0.1004 
                 A 
                 1.642917518 
               
               
                 1KG 
                 3:100878962 
                 rs13095226 
                 0.0579 
                 0.0004761 
                 C 
                 3.493854735 
               
               
                 1KG 
                 3:101053451 
                 rs7626245 
                 0.0712 
                 0.00003955 
                 C 
                 4.110092882 
               
               
                 1KG 
                 3:118210505 
                 rs1540819 
                 0.0379 
                 0.001249 
                 T 
                 3.227447405 
               
               
                 1KG 
                 3:119674993 
                 rs12637095 
                 0.0462 
                 0.0001092 
                 T 
                 −3.869184471 
               
               
                 1KG 
                 3:119681130 
                 rs1915098 
                 0.0533 
                 0.00002407 
                 A 
                 −4.223347742 
               
               
                 1KG 
                 3:120558458 
                 rs9713311 
                 0.0375 
                 0.0007681 
                 C 
                 3.364041473 
               
               
                 1KG 
                 3:130591125 
                 rs12632105 
                 0.0552 
                 0.6286 
                 C 
                 −0.4836983 
               
               
                 1KG 
                 3:154434339 
                 rs16822447 
                 0.055 
                 0.002918 
                 T 
                 −2.976246725 
               
               
                 1KG 
                 3:156261403 
                 rs13094238 
                 0.1084 
                 0.006705 
                 C 
                 −2.711151416 
               
               
                 1KG 
                 3:163192835 
                 rs4256145 
                 0.04 
                 0.00002249 
                 G 
                 −4.238617964 
               
               
                 1KG 
                 3:37504640 
                 rs11716363 
                 0.0509 
                 0.105 
                 T 
                 1.621082251 
               
               
                 1KG 
                 3:53233464 
                 rs12632671 
                 0.0924 
                 0.0002466 
                 A 
                 3.665765312 
               
               
                 1KG 
                 3:71584585 
                 rs2135548 
                 0.0422 
                 0.0001424 
                 G 
                 3.803962059 
               
               
                 1KG 
                 4:110878516 
                 rs10033900 
                 0.0409 
                 2.401E−11 
                 T 
                 6.679291601 
               
               
                 1KG 
                 4:128495772 
                 rs1443179 
                 0.1788 
                 0.001578 
                 T 
                 3.159943013 
               
               
                 1KG 
                 4:162971300 
                 rs17639345 
                 0.0515 
                 0.4416 
                 A 
                 0.769494177 
               
               
                 1KG 
                 4:165142286 
                 rs11736266 
                 0.0392 
                 0.1999 
                 C 
                 1.281836521 
               
               
                 1KG 
                 4:182181154 
                 rs9997006 
                 0.0571 
                 0.0008115 
                 T 
                 3.3488422 
               
               
                 1KG 
                 4:23188024 
                 chr4: 23188024 
                 0.2341 
                 0.002383 
                 A 
                 −3.037815254 
               
               
                 1KG 
                 4:36840346 
                 rs2376241 
                 0.0425 
                 0.001166 
                 T 
                 3.247069288 
               
               
                 1KG 
                 4:86877248 
                 rs28621471 
                 0.0475 
                 0.0008447 
                 A 
                 −3.337716127 
               
               
                 1KG 
                 5:106936632 
                 rs164700 
                 0.0614 
                 0.002048 
                 A 
                 3.083181798 
               
               
                 1KG 
                 5:113645446 
                 chr5: 113645446 
                 0.0556 
                 0.0006648 
                 G 
                 3.403698868 
               
               
                 1KG 
                 5:149749881 
                 chr5: 149749881 
                 0.0698 
                 0.006721 
                 C 
                 2.710361063 
               
               
                 1KG 
                 5:165133520 
                 chr5: 165133520 
                 0.0486 
                 0.00183 
                 C 
                 −3.116518819 
               
               
                 1KG 
                 5:21309600 
                 rs2883171 
                 0.0643 
                 0.00001405 
                 G 
                 4.343078347 
               
               
                 1KG 
                 5:26212150 
                 chr5: 26212150 
                 0.0804 
                 0.00001452 
                 C 
                 −4.335846876 
               
               
                 1KG 
                 5:52621268 
                 rs251525 
                 0.041 
                 0.0008037 
                 G 
                 3.351517359 
               
               
                 1KG 
                 5:5291813 
                 rs7720497 
                 0.0816 
                 0.0001015 
                 G 
                 3.886977878 
               
               
                 1KG 
                 5:61112540 
                 rs9291737 
                 0.0376 
                 0.00009344 
                 T 
                 −3.907023678 
               
               
                 1KG 
                 5:64292165 
                 rs10067691 
                 0.1288 
                 0.004567 
                 A 
                 −2.836087023 
               
               
                 1KG 
                 5:74385314 
                 rs12520598 
                 0.1038 
                 0.03102 
                 T 
                 −2.156816051 
               
               
                 1KG 
                 5:86468373 
                 rs2032794 
                 0.0458 
                 0.2518 
                 C 
                 1.145988284 
               
               
                 1KG 
                 6:109470664 
                 rs13192030 
                 0.6009 
                 0.5968 
                 T 
                 −0.529007856 
               
               
                 1KG 
                 6:116493827 
                 rs1999930 
                 0.042 
                 3.133E−07 
                 T 
                 −5.115265474 
               
               
                 1KG 
                 6:116529937 
                 rs509859 
                 0.0388 
                 0.00003054 
                 T 
                 −4.169401925 
               
               
                 1KG 
                 6:116568331 
                 rs12204816 
                 0.0553 
                 1.731E−07 
                 T 
                 −5.226124315 
               
               
                 1KG 
                 6:116596243 
                 rs12196141 
                 0.0431 
                 1.532E−07 
                 G 
                 −5.248671475 
               
               
                 1KG 
                 6:1324870 
                 rs9328048 
                 0.0454 
                 0.0002311 
                 T 
                 −3.68234321 
               
               
                 1KG 
                 6:132523980 
                 rs728371 
                 0.0414 
                 0.00005385 
                 A 
                 4.038256293 
               
               
                 1KG 
                 6:160376153 
                 rs1867348 
                 0.0647 
                 0.0005041 
                 T 
                 3.478568278 
               
               
                 1KG 
                 6:162467903 
                 chr6: 162467903 
                 0.0714 
                 0.001774 
                 A 
                 −3.12567083 
               
               
                 1KG 
                 6:31277268 
                 rs9366769 
                 0.0459 
                 0.000005154 
                 C 
                 −4.558419552 
               
               
                 1KG 
                 6:32011783 
                 rs9332739 
                 0.1165 
                 4.335E−12 
                 C 
                 −6.925806065 
               
               
                 1KG 
                 6:32022159 
                 rs641153 
                 0.0798 
                  2.94E−22 
                 A 
                 −9.702569373 
               
               
                 1KG 
                 6:33503177 
                 rs9461856 
                 0.037 
                 0.00007769 
                 A 
                 −3.951416437 
               
               
                 1KG 
                 6:43936560 
                 rs4711751 
                 0.0445 
                 0.0000218 
                 T 
                 4.245609514 
               
               
                 1KG 
                 6:55456674 
                 rs4260755 
                 0.0387 
                 0.000255 
                 A 
                 3.657185342 
               
               
                 1KG 
                 6:57396889 
                 rs9475939 
                 10.7214 
                 0.9806 
                 C 
                 0.02431669 
               
               
                 1KG 
                 6:7063989 
                 rs11755724 
                 0.0382 
                 0.0006616 
                 A 
                 −3.405016732 
               
               
                 1KG 
                 6:7152544 
                 rs1360751 
                 0.0379 
                 0.000209 
                 A 
                 3.707881999 
               
               
                 1KG 
                 6:93573222 
                 rs2037156 
                 0.0492 
                 0.001602 
                 G 
                 3.155542363 
               
               
                 HM2 
                 7:14123511 
                 rs7783337 
                 0.0552 
                 0.002751 
                 G 
                 2.99427264 
               
               
                 1KG 
                 7:23550807 
                 rs10280782 
                 0.0551 
                 0.000001593 
                 G 
                 −4.799200851 
               
               
                 1KG 
                 7:27475356 
                 rs17155281 
                 0.0513 
                 0.01156 
                 C 
                 −2.525298662 
               
               
                 1KG 
                 7:35595154 
                 rs343718 
                 0.0406 
                 0.1015 
                 A 
                 −1.637624735 
               
               
                 1KG 
                 7:43880667 
                 rs2730613 
                 0.0394 
                 0.001495 
                 C 
                 −3.175652343 
               
               
                 1KG 
                 7:54736904 
                 rs10225927 
                 0.0459 
                 0.0002957 
                 G 
                 3.619038192 
               
               
                 1KG 
                 7:86076557 
                 rs1358395 
                 0.042 
                 0.0001186 
                 A 
                 −3.849002081 
               
               
                 1KG 
                 8:123521501 
                 rs4282579 
                 0.039 
                 0.00007708 
                 G 
                 3.953302156 
               
               
                 1KG 
                 8:128550166 
                 rs10089310 
                 0.0599 
                 0.0004286 
                 A 
                 3.521816937 
               
               
                 1KG 
                 8:136110326 
                 rs13253938 
                 0.0394 
                 0.00001831 
                 G 
                 −4.284561447 
               
               
                 1KG 
                 8:13715406 
                 rs1384044 
                 0.038 
                 0.0006033 
                 T 
                 −3.430126462 
               
               
                 1KG 
                 8:139212254 
                 rs10103808 
                 0.0627 
                 0.000006651 
                 T 
                 4.504561932 
               
               
                 1KG 
                 8:14247492 
                 rs10503493 
                 0.0892 
                 0.003472 
                 A 
                 −2.922530154 
               
               
                 1KG 
                 8:19888502 
                 rs12678919 
                 0.0629 
                 0.6846 
                 G 
                 −0.406194085 
               
               
                 1KG 
                 8:20081107 
                 rs2270637 
                 0.0482 
                 0.0000319 
                 G 
                 −4.159460629 
               
               
                 1KG 
                 8:23138916 
                 rs13278062 
                 0.0486 
                 0.0006516 
                 T 
                 3.409173601 
               
               
                 1KG 
                 8:506479 
                 rs722782 
                 0.0642 
                 0.00004568 
                 A 
                 −4.076696774 
               
               
                 HM2 
                 8:96819457 
                 rs6982567 
                 0.051 
                 0.0006232 
                 T 
                 3.421311102 
               
               
                 1KG 
                 9:106704122 
                 rs1883025 
                 0.0434 
                 0.001275 
                 T 
                 −3.221548233 
               
               
                 1KG 
                 9:114121319 
                 rs10739343 
                 0.0454 
                 0.0003545 
                 A 
                 −3.571826678 
               
               
                 1KG 
                 9:15279578 
                 rs471364 
                 0.0578 
                 0.6198 
                 C 
                 −0.496133819 
               
               
                 1KG 
                 9:4536594 
                 rs10815017 
                 0.0463 
                 0.1325 
                 T 
                 −1.504316083 
               
               
                   
               
             
          
           
               
                 REF 
                 hg_18_BP 
                 OldSNP 
                 EA_OR 
                 ci− 
                 ci+ 
               
               
                   
               
               
                 1KG 
                 1:100166675 
                 chr1: 100166675 
                 1.3684 
                 1.144186809 
                 1.636549684 
               
               
                 1KG 
                 1:163986967 
                 chr1: 163986967 
                 0.7049 
                 0.550540184 
                 0.902539042 
               
               
                 1KG 
                 1:165795961 
                 rs1737478 
                 1.1357 
                 1.042474486 
                 1.237262405 
               
               
                 1KG 
                 1:185513773 
                 rs2453727 
                 1.0017 
                 0.931445644 
                 1.077253295 
               
               
                 1KG 
                 1:194925860 
                 rs1061170 
                 2.738975623 
                 0.337371025 
                 0.395108057 
               
               
                 1KG 
                 1:194963556 
                 rs1410996 
                 3.118178983 
                 0.292993407 
                 0.351026636 
               
               
                 1KG 
                 1:205461564 
                 rs1367068 
                 0.713368526 
                 1.232185134 
                 1.594762983 
               
               
                 1KG 
                 1:205515927 
                 rs12040406 
                 0.456183568 
                 1.624779296 
                 2.957510859 
               
               
                 1KG 
                 1:227122574 
                 rs6685751 
                 1.1607 
                 1.050904552 
                 1.281966557 
               
               
                 1KG 
                 1:228362314 
                 rs4846914 
                 1.040691019 
                 0.8919324 
                 1.035200436 
               
               
                 1KG 
                 1:247130153 
                 rs6587759 
                 1.3373 
                 1.139421475 
                 1.569543254 
               
               
                 1KG 
                 1:31101812 
                 rs2491146 
                 0.8641 
                 0.797534029 
                 0.936221883 
               
               
                 1KG 
                 1:5303445 
                 rs1326005 
                 0.9191 
                 0.84912884 
                 0.994837026 
               
               
                 1KG 
                 1:57219300 
                 rs1418473 
                 1.221 
                 1.06154585 
                 1.404405659 
               
               
                 1KG 
                 1:57677552 
                 rs11207037 
                 1.0234367 
                 0.897069196 
                 1.064270643 
               
               
                 1KG 
                 1:79360392 
                 rs17408651 
                 0.8501 
                 0.746068926 
                 0.968637059 
               
               
                 1KG 
                 10:124204438 
                 rs10490924 
                 3.1865 
                 2.915773499 
                 3.482363172 
               
               
                 1KG 
                 10:19392088 
                 rs11596472 
                 1.150747986 
                 0.708472416 
                 1.065900356 
               
               
                 1KG 
                 10:24883792 
                 rs16924889 
                 0.9404 
                 0.823218219 
                 1.074262133 
               
               
                 1KG 
                 10:32036318 
                 rs2277252 
                 1.1865 
                 1.089104498 
                 1.292605304 
               
               
                 1KG 
                 10:3945290 
                 rs11592003 
                 0.819470622 
                 1.099250661 
                 1.354679277 
               
               
                 1KG 
                 10:56380194 
                 rs61856267 
                 1.354829969 
                 0.637822044 
                 0.854143589 
               
               
                 1KG 
                 10:57479107 
                 chr10: 57479107 
                 1.1634 
                 1.035742699 
                 1.306791312 
               
               
                 1KG 
                 10:8226099 
                 rs2798832 
                 1.166 
                 1.0688119842 
                 1.272016057 
               
               
                 1KG 
                 10:88344492 
                 chr10: 88344492 
                 1.2144 
                 1.093721529 
                 1.348393829 
               
               
                 1KG 
                 10:88396729 
                 rs2803544 
                 1.2022 
                 1.08230953 
                 1.335371074 
               
               
                 1KG 
                 10:92382787 
                 rs7094579 
                 0.753 
                 0.636569261 
                 0.890726327 
               
               
                 1KG 
                 11:100149779 
                 rs625761 
                 0.863185153 
                 1.061944928 
                 1.263834135 
               
               
                 1KG 
                 11:103362906 
                 rs12798294 
                 0.8706 
                 0.801645611 
                 0.945485573 
               
               
                 1KG 
                 11:104185708 
                 chr11: 104185708 
                 1.7253 
                 1.120757671 
                 2.655935505 
               
               
                 1KG 
                 11:116154127 
                 rs964184 
                 0.963483958 
                 0.934028284 
                 1.153323116 
               
               
                 1KG 
                 11:1762440 
                 rs55911157 
                 0.7781 
                 0.696259928 
                 0.869559751 
               
               
                 1KG 
                 11:1768072 
                 rs72850977 
                 0.7792 
                 0.697927865 
                 0.869936093 
               
               
                 1KG 
                 11:32859894 
                 rs4755455 
                 0.9526 
                 0.864012372 
                 1.050270562 
               
               
                 1KG 
                 11:37597461 
                 rs10768315 
                 0.8472 
                 0.780710806 
                 0.919351743 
               
               
                 1KG 
                 11:61327359 
                 rs174547 
                 0.952380952 
                 0.972728922 
                 1.133409293 
               
               
                 1KG 
                 11:73662041 
                 rs513683 
                 0.8991 
                 0.833587156 
                 0.969761595 
               
               
                 1KG 
                 12:108379551 
                 rs2338104 
                 0.956022945 
                 0.97244804 
                 1.125115127 
               
               
                 1KG 
                 12:11233234 
                 chr12: 11233234 
                 1.1565 
                 1.005075037 
                 1.330738701 
               
               
                 1KG 
                 12:114010367 
                 rs11067403 
                 0.871231922 
                 1.06208193 
                 1.240436169 
               
               
                 1KG 
                 12:123850701 
                 rs5888 
                 1.002004008 
                 0.925099479 
                 1.076645294 
               
               
                 1KG 
                 12:19878442 
                 rs1492116 
                 0.842034355 
                 1.087553267 
                 1.296850281 
               
               
                 1KG 
                 12:2290505 
                 rs10848645 
                 1.190617931 
                 0.771257915 
                 0.914651243 
               
               
                 1KG 
                 12:45893566 
                 rs11183802 
                 1.3253 
                 1.109670194 
                 1.582830736 
               
               
                 1KG 
                 12:50881293 
                 rs7958529 
                 0.844951415 
                 1.08571217 
                 1.290095375 
               
               
                 1KG 
                 12:80847264 
                 rs7973032 
                 0.958864704 
                 0.900329289 
                 1.208047348 
               
               
                 1KG 
                 12:92165329 
                 rs7973431 
                 1.0087 
                 0.930447499 
                 1.093533693 
               
               
                 1KG 
                 13:105365389 
                 rs4771513 
                 0.949667616 
                 0.937272922 
                 1.183016146 
               
               
                 1KG 
                 13:30736688 
                 rs1912795 
                 1.1392 
                 1.057642381 
                 1.227046745 
               
               
                 1KG 
                 13:78960018 
                 rs17071512 
                 0.805347507 
                 1.077006473 
                 1.431578109 
               
               
                 1KG 
                 13:83069357 
                 rs7317763 
                 1.0722 
                 0.99563417 
                 1.154653862 
               
               
                 1KG 
                 14:95216646 
                 rs8011890 
                 1.4427 
                 1.213902478 
                 1.714621502 
               
               
                 1KG 
                 15:30811243 
                 rs3743105 
                 0.9607 
                 0.89157199 
                 1.035187849 
               
               
                 1KG 
                 15:35201758 
                 chr15: 35201758 
                 1.3375 
                 1.168314603 
                 1.531185389 
               
               
                 1KG 
                 15:35992085 
                 rs16965939 
                 0.6687 
                 0.556836427 
                 0.803035987 
               
               
                 1KG 
                 15:40375218 
                 rs12908430 
                 0.6083 
                 0.461058153 
                 0.802564464 
               
               
                 1KG 
                 15:47957127 
                 chr15: 47957127 
                 0.1281 
                 0.019366935 
                 0.847300327 
               
               
                 1KG 
                 15:56465804 
                 rs10468017 
                 0.8324 
                 0.762126913 
                 0.909152725 
               
               
                 1KG 
                 15:56475172 
                 rs493258 
                 1.179106237 
                 0.787845932 
                 0.912962269 
               
               
                 1KG 
                 15:59828725 
                 rs11854497 
                 0.825 
                 0.730884457 
                 0.931234743 
               
               
                 1KG 
                 15:87312556 
                 rs11854658 
                 0.859623485 
                 1.077479798 
                 1.255955696 
               
               
                 1KG 
                 15:87314645 
                 rs11856826 
                 0.853096741 
                 1.082535879 
                 1.269290807 
               
               
                 1KG 
                 16:11814579 
                 rs2024393 
                 1.0619 
                 0.932132559 
                 1.2097331 
               
               
                 1KG 
                 16:17310751 
                 chr16: 17310751 
                 0.763067531 
                 1.143608648 
                 1.501746469 
               
               
                 1KG 
                 16:23091095 
                 rs4967980 
                 1.204093919 
                 0.760387315 
                 0.907077533 
               
               
                 1KG 
                 16:55550825 
                 rs3764261 
                 1.1631 
                 1.077083424 
                 1.255985916 
               
               
                 1KG 
                 16:66459571 
                 rs2271293 
                 1.0897 
                 0.973749134 
                 1.219457916 
               
               
                 1KG 
                 16:72289810 
                 rs2127740 
                 1.2894 
                 1.153103489 
                 1.44180672 
               
               
                 1KG 
                 16:74921678 
                 rs8053796 
                 1.1928 
                 1.085698419 
                 1.310466898 
               
               
                 1KG 
                 16:74929641 
                 rs6564324 
                 1.197031362 
                 0.760240364 
                 0.917990142 
               
               
                 1KG 
                 16:84929276 
                 rs12926103 
                 1.4308 
                 1.207907747 
                 1.694822013 
               
               
                 1KG 
                 16:85846518 
                 rs3748391 
                 0.8754 
                 0.814163271 
                 0.941242607 
               
               
                 1KG 
                 17:45980827 
                 rs8076470 
                 1.1472 
                 1.062359301 
                 1.238816131 
               
               
                 1KG 
                 17:72483712 
                 chr17: 72483712 
                 0.769882208 
                 0.971080172 
                 1.737386118 
               
               
                 1KG 
                 17:73838135 
                 rs16971055 
                 1.3213 
                 1.08655061 
                 1.606767024 
               
               
                 1KG 
                 17:77136846 
                 rs4073997 
                 1.1002 
                 0.784117797 
                 1.54369668 
               
               
                 1KG 
                 18:34111545 
                 rs8091635 
                 1.1987 
                 1.108094237 
                 1.296714342 
               
               
                 1KG 
                 18:34125717 
                 rs17628762 
                 1.188 
                 1.101004804 
                 1.281869066 
               
               
                 1KG 
                 18:36481096 
                 rs2469875 
                 0.995520159 
                 0.934232358 
                 1.080052775 
               
               
                 1KG 
                 18:45421212 
                 rs4939883 
                 1.0146 
                 0.922413611 
                 1.115999534 
               
               
                 1KG 
                 18:53934507 
                 rs529478 
                 0.832986256 
                 1.099366535 
                 1.310936984 
               
               
                 1KG 
                 18:68641554 
                 rs11876415 
                 0.940203084 
                 0.966961479 
                 1.169896614 
               
               
                 1KG 
                 18:72988032 
                 rs1789110 
                 1.201778632 
                 0.77026039 
                 0.898904344 
               
               
                 1KG 
                 19:36639376 
                 rs2052572 
                 1.1729 
                 1.082545611 
                 1.270795795 
               
               
                 1KG 
                 19:5792356 
                 rs3760775 
                 0.7243 
                 0.611227769 
                 0.858289685 
               
               
                 HM2 
                 19:59425996 
                 rs7260457 
                 0.7477 
                 0.61125476 
                 0.914602759 
               
               
                 1KG 
                 19:6669387 
                 rs2230199 
                 1.6842 
                 1.49969038 
                 1.891410172 
               
               
                 1KG 
                 19:8375738 
                 rs2967605 
                 1.0509 
                 0.951864049 
                 1.160240069 
               
               
                 1KG 
                 2:124751486 
                 rs9308649 
                 0.834724541 
                 1.091286745 
                 1.315148385 
               
               
                 1KG 
                 2:180796214 
                 chr2: 180796214 
                 0.8419 
                 0.762859019 
                 0.929130537 
               
               
                 1KG 
                 2:189854831 
                 rs10207860 
                 0.9 
                 0.774683658 
                 1.045588081 
               
               
                 1KG 
                 2:20201501 
                 rs6531212 
                 0.8491 
                 0.786305163 
                 0.916909673 
               
               
                 1KG 
                 2:44132778 
                 chr2: 44132778 
                 0.684415851 
                 1.192363625 
                 1.790404508 
               
               
                 1KG 
                 2:71597893 
                 rs13402171 
                 1.0004 
                 0.882461533 
                 1.134100607 
               
               
                 1KG 
                 2:76232489 
                 rs1851808 
                 1.149954002 
                 0.805604829 
                 0.938678782 
               
               
                 1KG 
                 20:42475778 
                 rs1800961 
                 0.8286 
                 0.665286337 
                 1.032003698 
               
               
                 1KG 
                 20:44009909 
                 rs7679 
                 0.943307235 
                 0.964346358 
                 1.165361388 
               
               
                 1KG 
                 20:4486243 
                 rs958646 
                 0.9867 
                 0.865104269 
                 1.12538676 
               
               
                 1KG 
                 20:56979160 
                 rs235195 
                 1.364 
                 1.112468655 
                 1.672403075 
               
               
                 HM2 
                 22:31414511 
                 rs9621532 
                 0.719838756 
                 1.15907705 
                 1.665011519 
               
               
                 1KG 
                 22:36259705 
                 rs1079982 
                 0.7054 
                 0.588664857 
                 0.845284298 
               
               
                 1KG 
                 22:43172593 
                 rs135912 
                 0.951746455 
                 0.954110877 
                 1.157067294 
               
               
                 1KG 
                 22:47467676 
                 rs5771717 
                 1.1586 
                 0.97199597 
                 1.381028318 
               
               
                 1KG 
                 3:100878962 
                 rs13095226 
                 1.224439819 
                 0.729083182 
                 0.914846078 
               
               
                 1KG 
                 3:101053451 
                 rs7626245 
                 1.3399 
                 1.165375071 
                 1.540561537 
               
               
                 1KG 
                 3:118210505 
                 rs1540819 
                 1.1303 
                 1.049379549 
                 1.217460442 
               
               
                 1KG 
                 3:119674993 
                 rs12637095 
                 0.836470096 
                 1.092001781 
                 1.308807619 
               
               
                 1KG 
                 3:119681130 
                 rs1915098 
                 0.7983 
                 0.719111532 
                 0.886208692 
               
               
                 1KG 
                 3:120558458 
                 rs9713311 
                 1.134558657 
                 0.818940599 
                 0.948623088 
               
               
                 1KG 
                 3:130591125 
                 rs12632105 
                 0.9737 
                 0.873852195 
                 1.084956581 
               
               
                 1KG 
                 3:154434339 
                 rs16822447 
                 0.848896435 
                 1.057616811 
                 1.312085801 
               
               
                 1KG 
                 3:156261403 
                 rs13094238 
                 0.745378652 
                 1.084803573 
                 1.659185686 
               
               
                 1KG 
                 3:163192835 
                 rs4256145 
                 0.843881857 
                 1.0956445 
                 1.281642905 
               
               
                 1KG 
                 3:37504640 
                 rs11716363 
                 1.0861 
                 0.982975875 
                 1.200042891 
               
               
                 1KG 
                 3:53233464 
                 rs12632671 
                 1.4031 
                 1.170674495 
                 1.681671223 
               
               
                 1KG 
                 3:71584585 
                 rs2135548 
                 1.173984503 
                 0.784180919 
                 0.925249802 
               
               
                 1KG 
                 4:110878516 
                 rs10033900 
                 1.3144 
                 1.213145154 
                 1.424106056 
               
               
                 1KG 
                 4:128495772 
                 rs1443179 
                 1.7594 
                 1.239272906 
                 2.497826221 
               
               
                 1KG 
                 4:162971300 
                 rs17639345 
                 1.0405 
                 0.940598755 
                 1.151011783 
               
               
                 1KG 
                 4:165142286 
                 rs11736266 
                 1.051524711 
                 0.880669191 
                 1.026947473 
               
               
                 1KG 
                 4:182181154 
                 rs9997006 
                 1.2106 
                 1.082420898 
                 1.353957932 
               
               
                 1KG 
                 4:23188024 
                 chr4: 23188024 
                 0.491 
                 0.310321274 
                 0.776875517 
               
               
                 1KG 
                 4:36840346 
                 rs2376241 
                 1.148 
                 1.056246196 
                 1.247724257 
               
               
                 1KG 
                 4:86877248 
                 rs28621471 
                 0.8532 
                 0.777352555 
                 0.936447993 
               
               
                 1KG 
                 5:106936632 
                 rs164700 
                 1.2085 
                 1.071474697 
                 1.363048753 
               
               
                 1KG 
                 5:113645446 
                 chr5: 113645446 
                 1.208459215 
                 0.74206223 
                 0.922774698 
               
               
                 1KG 
                 5:149749881 
                 chr5: 149749881 
                 1.2083 
                 1.053803935 
                 1.385446421 
               
               
                 1KG 
                 5:165133520 
                 chr5: 165133520 
                 0.859328005 
                 1.05796641 
                 1.280000648 
               
               
                 1KG 
                 5:21309600 
                 rs2883171 
                 1.322401481 
                 0.66665848 
                 0.857768193 
               
               
                 1KG 
                 5:26212150 
                 chr5: 26212150 
                 0.705566923 
                 1.210664828 
                 1.659203476 
               
               
                 1KG 
                 5:52621268 
                 rs251525 
                 1.147183664 
                 0.804390886 
                 0.944641347 
               
               
                 1KG 
                 5:5291813 
                 rs7720497 
                 1.373249107 
                 0.620570822 
                 0.854495927 
               
               
                 1KG 
                 5:61112540 
                 rs9291737 
                 0.863483292 
                 1.075821689 
                 1.246670916 
               
               
                 1KG 
                 5:64292165 
                 rs10067691 
                 0.694 
                 0.539166248 
                 0.893297758 
               
               
                 1KG 
                 5:74385314 
                 rs12520598 
                 0.7993 
                 0.652158966 
                 0.979639204 
               
               
                 1KG 
                 5:86468373 
                 rs2032794 
                 1.053962901 
                 0.867339108 
                 1.037911737 
               
               
                 1KG 
                 6:109470664 
                 rs13192030 
                 0.727696114 
                 0.423207678 
                 4.462172449 
               
               
                 1KG 
                 6:116493827 
                 rs1999930 
                 0.8068 
                 0.743044404 
                 0.876026031 
               
               
                 1KG 
                 6:116529937 
                 rs509859 
                 0.8508 
                 0.78849738 
                 0.918025422 
               
               
                 1KG 
                 6:116568331 
                 rs12204816 
                 0.7488 
                 0.671882803 
                 0.834522684 
               
               
                 1KG 
                 6:116596243 
                 rs12196141 
                 0.797448166 
                 1.152418114 
                 1.364535997 
               
               
                 1KG 
                 6:1324870 
                 rs9328048 
                 0.846 
                 0.773971739 
                 0.924731439 
               
               
                 1KG 
                 6:132523980 
                 rs728371 
                 1.1821 
                 1.089968196 
                 1.282019434 
               
               
                 1KG 
                 6:160376153 
                 rs1867348 
                 1.2525 
                 1.103326331 
                 1.421842483 
               
               
                 1KG 
                 6:162467903 
                 chr6: 162467903 
                 0.8001 
                 0.695612477 
                 0.920282529 
               
               
                 1KG 
                 6:31277268 
                 rs9366769 
                 0.81109579 
                 1.126826323 
                 1.348958911 
               
               
                 1KG 
                 6:32011783 
                 rs9332739 
                 0.4463 
                 0.355189472 
                 0.560781514 
               
               
                 1KG 
                 6:32022159 
                 rs641153 
                 0.461 
                 0.394251899 
                 0.539048767 
               
               
                 1KG 
                 6:33503177 
                 rs9461856 
                 0.8641 
                 0.803653738 
                 0.929092685 
               
               
                 1KG 
                 6:43936560 
                 rs4711751 
                 1.2081 
                 1.10719399 
                 1.318202251 
               
               
                 1KG 
                 6:55456674 
                 rs4260755 
                 1.152 
                 1.0678503 
                 1.24278094 
               
               
                 1KG 
                 6:57396889 
                 rs9475939 
                 1.297521733 
                 5.76296E−10 
                 1030683399 
               
               
                 1KG 
                 6:7063989 
                 rs11755724 
                 0.878 
                 0.814663051 
                 0.946261155 
               
               
                 1KG 
                 6:7152544 
                 rs1360751 
                 1.1507 
                 1.068319072 
                 1.23943354 
               
               
                 1KG 
                 6:93573222 
                 rs2037156 
                 1.167951413 
                 0.777490942 
                 0.942877146 
               
               
                 HM2 
                 7:14123511 
                 rs7783337 
                 1.179941003 
                 0.76059334 
                 0.944336759 
               
               
                 1KG 
                 7:23550807 
                 rs10280782 
                 0.767754319 
                 1.169164621 
                 1.451041384 
               
               
                 1KG 
                 7:27475356 
                 rs17155281 
                 0.878580214 
                 1.029321726 
                 1.25859506 
               
               
                 1KG 
                 7:35595154 
                 rs343718 
                 0.9357 
                 0.864126277 
                 1.01320202 
               
               
                 1KG 
                 7:43880667 
                 rs2730613 
                 0.882378893 
                 1.049075952 
                 1.224285895 
               
               
                 1KG 
                 7:54736904 
                 rs10225927 
                 1.180637544 
                 0.774127582 
                 0.926732255 
               
               
                 1KG 
                 7:86076557 
                 rs1358395 
                 0.8507 
                 0.783475303 
                 0.923692792 
               
               
                 1KG 
                 8:123521501 
                 rs4282579 
                 1.166725003 
                 0.794024723 
                 0.925185815 
               
               
                 1KG 
                 8:128550166 
                 rs10089310 
                 1.2349 
                 1.098105031 
                 1.38873602 
               
               
                 1KG 
                 8:136110326 
                 rs13253938 
                 0.844808651 
                 1.095730349 
                 1.27873221 
               
               
                 1KG 
                 8:13715406 
                 rs1384044 
                 0.8777 
                 0.814703994 
                 0.945567096 
               
               
                 1KG 
                 8:139212254 
                 rs10103808 
                 1.326259947 
                 0.666806813 
                 0.852594768 
               
               
                 1KG 
                 8:14247492 
                 rs10503493 
                 0.7705 
                 0.646910306 
                 0.917701023 
               
               
                 1KG 
                 8:19888502 
                 rs12678919 
                 0.974753875 
                 0.906908493 
                 1.160503864 
               
               
                 1KG 
                 8:20081107 
                 rs2270637 
                 0.818330606 
                 1.111840623 
                 1.343073791 
               
               
                 1KG 
                 8:23138916 
                 rs13278062 
                 1.1804 
                 1.073149051 
                 1.298369653 
               
               
                 1KG 
                 8:506479 
                 rs722782 
                 0.7698 
                 0.678781135 
                 0.873023733 
               
               
                 HM2 
                 8:96819457 
                 rs6982567 
                 1.1905 
                 1.077252035 
                 1.315653351 
               
               
                 1KG 
                 9:106704122 
                 rs1883025 
                 0.8697 
                 0.79877901 
                 0.946917834 
               
               
                 1KG 
                 9:114121319 
                 rs10739343 
                 0.8504 
                 0.777997124 
                 0.929540917 
               
               
                 1KG 
                 9:15279578 
                 rs471364 
                 0.971722865 
                 0.918876671 
                 1.152545107 
               
               
                 1KG 
                 9:4536594 
                 rs10815017 
                 0.9327 
                 0.851786242 
                 1.021300001 
               
               
                   
               
             
          
           
               
                   
                 REF 
                 hg_18_BP 
                 OldSNP 
                 SNP 
                 F_EA_A 
               
               
                   
                   
               
               
                   
                 1KG 
                 1:100166675 
                 chr1: 100166675 
                 rs115952936 
                 0.0493 
               
               
                   
                 1KG 
                 1:163986967 
                 chr1: 163986967 
                 chr1: 163986967 
                 0.052 
               
               
                   
                 1KG 
                 1:165795961 
                 rs1737478 
                 rs1737478 
                 0.2451 
               
               
                   
                 1KG 
                 1:185513773 
                 rs2453727 
                 rs2453727 
                 0.4977 
               
               
                   
                 1KG 
                 1:194925860 
                 rs1061170 
                 rs1061170 
                 0.6091 
               
               
                   
                 1KG 
                 1:194963556 
                 rs1410996 
                 rs1410996 
                 0.7996 
               
               
                   
                 1KG 
                 1:205461564 
                 rs1367068 
                 rs1367068 
                 0.1988 
               
               
                   
                 1KG 
                 1:205515927 
                 rs12040406 
                 rs12040406 
                 0.0826 
               
               
                   
                 1KG 
                 1:227122574 
                 rs6685751 
                 rs6685751 
                 0.4818 
               
               
                   
                 1KG 
                 1:228362314 
                 rs4846914 
                 rs4846914 
                 0.4062 
               
               
                   
                 1KG 
                 1:247130153 
                 rs6587759 
                 rs6587759 
                 0.0635 
               
               
                   
                 1KG 
                 1:31101812 
                 rs2491146 
                 rs2491146 
                 0.3668 
               
               
                   
                 1KG 
                 1:5303445 
                 rs1326005 
                 rs1326005 
                 0.3841 
               
               
                   
                 1KG 
                 1:57219300 
                 rs1418473 
                 rs1418473 
                 0.0866 
               
               
                   
                 1KG 
                 1:57677552 
                 rs11207037 
                 rs11207037 
                 0.2493 
               
               
                   
                 1KG 
                 1:79360392 
                 rs17408651 
                 rs17408651 
                 0.1174 
               
               
                   
                 1KG 
                 10:124204438 
                 rs10490924 
                 rs10490924 
                 0.4144 
               
               
                   
                 1KG 
                 10:19392088 
                 rs11596472 
                 rs11596472 
                 0.0859 
               
               
                   
                 1KG 
                 10:24883792 
                 rs16924889 
                 rs16924889 
                 0.0865 
               
               
                   
                 1KG 
                 10:32036318 
                 rs2277252 
                 rs2277252 
                 0.4765 
               
               
                   
                 1KG 
                 10:3945290 
                 rs11592003 
                 rs11592003 
                 0.1377 
               
               
                   
                 1KG 
                 10:56380194 
                 rs61856267 
                 rs61856267 
                 0.1135 
               
               
                   
                 1KG 
                 10:57479107 
                 chr10: 57479107 
                 chr10: 57479107 
                 0.1191 
               
               
                   
                 1KG 
                 10:8226099 
                 rs2798832 
                 rs2798832 
                 0.266 
               
               
                   
                 1KG 
                 10:88344492 
                 chr10: 88344492 
                 rs55829833 
                 0.1597 
               
               
                   
                 1KG 
                 10:88396729 
                 rs2803544 
                 rs2803544 
                 0.1528 
               
               
                   
                 1KG 
                 10:92382787 
                 rs7094579 
                 rs7094579 
                 0.0451 
               
               
                   
                 1KG 
                 11:100149779 
                 rs625761 
                 rs625761 
                 0.2381 
               
               
                   
                 1KG 
                 11:103362906 
                 rs12798294 
                 rs12798294 
                 0.2689 
               
               
                   
                 1KG 
                 11:104185708 
                 chr11: 104185708 
                 chr11: 104185708 
                 0.0478 
               
               
                   
                 1KG 
                 11:116154127 
                 rs964184 
                 rs964184 
                 0.138 
               
               
                   
                 1KG 
                 11:1762440 
                 rs55911157 
                 rs55911157 
                 0.1489 
               
               
                   
                 1KG 
                 11:1768072 
                 rs72850977 
                 rs72850977 
                 0.148 
               
               
                   
                 1KG 
                 11:32859894 
                 rs4755455 
                 rs4755455 
                 0.1684 
               
               
                   
                 1KG 
                 11:37597461 
                 rs10768315 
                 rs10768315 
                 0.2642 
               
               
                   
                 1KG 
                 11:61327359 
                 rs174547 
                 rs174547 
                 0.334 
               
               
                   
                 1KG 
                 11:73662041 
                 rs513683 
                 rs513683 
                 0.4409 
               
               
                   
                 1KG 
                 12:108379551 
                 rs2338104 
                 rs2338104 
                 0.5373 
               
               
                   
                 1KG 
                 12:11233234 
                 chr12: 11233234 
                 chr12: 11233234 
                 0.1532 
               
               
                   
                 1KG 
                 12:114010367 
                 rs11067403 
                 rs11067403 
                 0.3109 
               
               
                   
                 1KG 
                 12:123850701 
                 rs5888 
                 rs5888 
                 0.5111 
               
               
                   
                 1KG 
                 12:19878442 
                 rs1492116 
                 rs1492116 
                 0.21 
               
               
                   
                 1KG 
                 12:2290505 
                 rs10848645 
                 rs10848645 
                 0.429 
               
               
                   
                 1KG 
                 12:45893566 
                 rs11183802 
                 rs11183802 
                 0.0774 
               
               
                   
                 1KG 
                 12:50881293 
                 rs7958529 
                 rs7958529 
                 0.3262 
               
               
                   
                 1KG 
                 12:80847264 
                 rs7973032 
                 rs7973032 
                 0.0709 
               
               
                   
                 1KG 
                 12:92165329 
                 rs7973431 
                 rs7973431 
                 0.3164 
               
               
                   
                 1KG 
                 13:105365389 
                 rs4771513 
                 rs4771513 
                 0.1262 
               
               
                   
                 1KG 
                 13:30736688 
                 rs1912795 
                 rs1912795 
                 0.4579 
               
               
                   
                 1KG 
                 13:78960018 
                 rs17071512 
                 rs17071512 
                 0.0961 
               
               
                   
                 1KG 
                 13:83069357 
                 rs7317763 
                 rs7317763 
                 0.4613 
               
               
                   
                 1KG 
                 14:95216646 
                 rs8011890 
                 rs8011890 
                 0.099 
               
               
                   
                 1KG 
                 15:30811243 
                 rs3743105 
                 rs3743105 
                 0.4142 
               
               
                   
                 1KG 
                 15:35201758 
                 chr15: 35201758 
                 chr15: 35201758 
                 0.1508 
               
               
                   
                 1KG 
                 15:35992085 
                 rs16965939 
                 rs16965939 
                 0.0907 
               
               
                   
                 1KG 
                 15:40375218 
                 rs12908430 
                 rs12908430 
                 0.0812 
               
               
                   
                 1KG 
                 15:47957127 
                 chr15: 47957127 
                 chr15: 47957127 
                 0.0105 
               
               
                   
                 1KG 
                 15:56465804 
                 rs10468017 
                 rs10468017 
                 0.2564 
               
               
                   
                 1KG 
                 15:56475172 
                 rs493258 
                 rs493258 
                 0.5682 
               
               
                   
                 1KG 
                 15:59828725 
                 rs11854497 
                 rs11854497 
                 0.1036 
               
               
                   
                 1KG 
                 15:87312556 
                 rs11854658 
                 rs11854658 
                 0.3236 
               
               
                   
                 1KG 
                 15:87314645 
                 rs11856826 
                 rs11856826 
                 0.3423 
               
               
                   
                 1KG 
                 16:11814579 
                 rs2024393 
                 rs2024393 
                 0.16 
               
               
                   
                 1KG 
                 16:17310751 
                 chr16: 17310751 
                 rs56005502 
                 0.0836 
               
               
                   
                 1KG 
                 16:23091095 
                 rs4967980 
                 rs4967980 
                 0.2565 
               
               
                   
                 1KG 
                 16:55550825 
                 rs3764261 
                 rs3764261 
                 0.36 
               
               
                   
                 1KG 
                 16:66459571 
                 rs2271293 
                 rs2271293 
                 0.1249 
               
               
                   
                 1KG 
                 16:72289810 
                 rs2127740 
                 rs2127740 
                 0.1392 
               
               
                   
                 1KG 
                 16:74921678 
                 rs8053796 
                 rs8053796 
                 0.2789 
               
               
                   
                 1KG 
                 16:74929641 
                 rs6564324 
                 rs6564324 
                 0.2837 
               
               
                   
                 1KG 
                 16:84929276 
                 rs12926103 
                 rs12926103 
                 0.0664 
               
               
                   
                 1KG 
                 16:85846518 
                 rs3748391 
                 rs3748391 
                 0.518 
               
               
                   
                 1KG 
                 17:45980827 
                 rs8076470 
                 rs8076470 
                 0.4062 
               
               
                   
                 1KG 
                 17:72483712 
                 chr17: 72483712 
                 chr17: 72483712 
                 0.0546 
               
               
                   
                 1KG 
                 17:73838135 
                 rs16971055 
                 rs16971055 
                 0.096 
               
               
                   
                 1KG 
                 17:77136846 
                 rs4073997 
                 rs4073997 
                 0.212 
               
               
                   
                 1KG 
                 18:34111545 
                 rs8091635 
                 rs8091635 
                 0.3871 
               
               
                   
                 1KG 
                 18:34125717 
                 rs17628762 
                 rs17628762 
                 0.3824 
               
               
                   
                 1KG 
                 18:36481096 
                 rs2469875 
                 rs2469875 
                 0.4832 
               
               
                   
                 1KG 
                 18:45421212 
                 rs4939883 
                 rs4939883 
                 0.1743 
               
               
                   
                 1KG 
                 18:53934507 
                 rs529478 
                 rs529478 
                 0.4834 
               
               
                   
                 1KG 
                 18:68641554 
                 rs11876415 
                 rs11876415 
                 0.3702 
               
               
                   
                 1KG 
                 18:72988032 
                 rs1789110 
                 rs1789110 
                 0.4122 
               
               
                   
                 1KG 
                 19:36639376 
                 rs2052572 
                 rs2052572 
                 0.3482 
               
               
                   
                 1KG 
                 19:5792356 
                 rs3760775 
                 rs3760775 
                 0.055 
               
               
                   
                 HM2 
                 19:59425996 
                 rs7260457 
                 rs7260457 
                 0.3679 
               
               
                   
                 1KG 
                 19:6669387 
                 rs2230199 
                 rs2230199 
                 0.2439 
               
               
                   
                 1KG 
                 19:8375738 
                 rs2967605 
                 rs2967605 
                 0.1811 
               
               
                   
                 1KG 
                 2:124751486 
                 rs9308649 
                 rs9308649 
                 0.1847 
               
               
                   
                 1KG 
                 2:180796214 
                 chr2: 180796214 
                 chr2: 180796214 
                 0.1728 
               
               
                   
                 1KG 
                 2:189854831 
                 rs10207860 
                 rs10207860 
                 0.0682 
               
               
                   
                 1KG 
                 2:20201501 
                 rs6531212 
                 rs6531212 
                 0.3177 
               
               
                   
                 1KG 
                 2:44132778 
                 chr2: 44132778 
                 chr2: 44132778 
                 0.0626 
               
               
                   
                 1KG 
                 2:71597893 
                 rs13402171 
                 rs13402171 
                 0.0904 
               
               
                   
                 1KG 
                 2:76232489 
                 rs1851808 
                 rs1851808 
                 0.3926 
               
               
                   
                 1KG 
                 20:42475778 
                 rs1800961 
                 rs1800961 
                 0.0264 
               
               
                   
                 1KG 
                 20:44009909 
                 rs7679 
                 rs7679 
                 0.1804 
               
               
                   
                 1KG 
                 20:4486243 
                 rs958646 
                 rs958646 
                 0.0838 
               
               
                   
                 1KG 
                 20:56979160 
                 rs235195 
                 rs235195 
                 0.1336 
               
               
                   
                 HM2 
                 22:31414511 
                 rs9621532 
                 rs9621532 
                 0.0366 
               
               
                   
                 1KG 
                 22:36259705 
                 rs1079982 
                 rs1079982 
                 0.0471 
               
               
                   
                 1KG 
                 22:43172593 
                 rs135912 
                 rs135912 
                 0.2652 
               
               
                   
                 1KG 
                 22:47467676 
                 rs5771717 
                 rs5771717 
                 0.1034 
               
               
                   
                 1KG 
                 3:100878962 
                 rs13095226 
                 rs13095226 
                 0.1228 
               
               
                   
                 1KG 
                 3:101053451 
                 rs7626245 
                 rs7626245 
                 0.0904 
               
               
                   
                 1KG 
                 3:118210505 
                 rs1540819 
                 rs1540819 
                 0.4652 
               
               
                   
                 1KG 
                 3:119674993 
                 rs12637095 
                 rs12637095 
                 0.1955 
               
               
                   
                 1KG 
                 3:119681130 
                 rs1915098 
                 rs1915098 
                 0.1414 
               
               
                   
                 1KG 
                 3:120558458 
                 rs9713311 
                 rs9713311 
                 0.4048 
               
               
                   
                 1KG 
                 3:130591125 
                 rs12632105 
                 rs12632105 
                 0.1669 
               
               
                   
                 1KG 
                 3:154434339 
                 rs16822447 
                 r816822447 
                 0.1363 
               
               
                   
                 1KG 
                 3:156261403 
                 rs13094238 
                 rs13094238 
                 0.1396 
               
               
                   
                 1KG 
                 3:163192835 
                 rs4256145 
                 rs4256145 
                 0.3055 
               
               
                   
                 1KG 
                 3:37504640 
                 rs11716363 
                 rs11716363 
                 0.1892 
               
               
                   
                 1KG 
                 3:53233464 
                 rs12632671 
                 rs12632671 
                 0.0676 
               
               
                   
                 1KG 
                 3:71584585 
                 rs2135548 
                 rs2135548 
                 0.2698 
               
               
                   
                 1KG 
                 4:110878516 
                 rs10033900 
                 rs10033900 
                 0.5205 
               
               
                   
                 1KG 
                 4:128495772 
                 rs1443179 
                 rs1443179 
                 0.0388 
               
               
                   
                 1KG 
                 4:162971300 
                 rs17639345 
                 rs17639345 
                 0.1539 
               
               
                   
                 1KG 
                 4:165142286 
                 rs11736266 
                 rs11736266 
                 0.522 
               
               
                   
                 1KG 
                 4:182181154 
                 rs9997006 
                 rs9997006 
                 0.3841 
               
               
                   
                 1KG 
                 4:23188024 
                 chr4: 23188024 
                 chr4: 23188024 
                 0.0345 
               
               
                   
                 1KG 
                 4:36840346 
                 rs2376241 
                 rs2376241 
                 0.2687 
               
               
                   
                 1KG 
                 4:86877248 
                 rs28621471 
                 rs28621471 
                 0.2253 
               
               
                   
                 1KG 
                 5:106936632 
                 rs164700 
                 rs164700 
                 0.1655 
               
               
                   
                 1KG 
                 5:113645446 
                 chr5: 113645446 
                 chr5: 113645446 
                 0.1512 
               
               
                   
                 1KG 
                 5:149749881 
                 chr5: 149749881 
                 chr5: 149749881 
                 0.0812 
               
               
                   
                 1KG 
                 5:165133520 
                 chr5: 165133520 
                 chr5: 165133520 
                 0.1731 
               
               
                   
                 1KG 
                 5:21309600 
                 rs2883171 
                 rs2883171 
                 0.137 
               
               
                   
                 1KG 
                 5:26212150 
                 chr5: 26212150 
                 chr5: 26212150 
                 0.0567 
               
               
                   
                 1KG 
                 5:52621268 
                 rs251525 
                 rs251525 
                 0.3323 
               
               
                   
                 1KG 
                 5:5291813 
                 rs7720497 
                 rs7720497 
                 0.068 
               
               
                   
                 1KG 
                 5:61112540 
                 rs9291737 
                 rs9291737 
                 0.3857 
               
               
                   
                 1KG 
                 5:64292165 
                 rs10067691 
                 rs10067691 
                 0.0525 
               
               
                   
                 1KG 
                 5:74385314 
                 rs12520598 
                 rs12520598 
                 0.0438 
               
               
                   
                 1KG 
                 5:86468373 
                 rs2032794 
                 rs2032794 
                 0.2204 
               
               
                   
                 1KG 
                 6:109470664 
                 rs13192030 
                 rs13192030 
                 0.0366 
               
               
                   
                 1KG 
                 6:116493827 
                 rs1999930 
                 rs1999930 
                 0.2595 
               
               
                   
                 1KG 
                 6:116529937 
                 rs509859 
                 rs509859 
                 0.3742 
               
               
                   
                 1KG 
                 6:116568331 
                 rs12204816 
                 rs12204816 
                 0.1906 
               
               
                   
                 1KG 
                 6:116596243 
                 rs12196141 
                 rs12196141 
                 0.2457 
               
               
                   
                 1KG 
                 6:1324870 
                 rs9328048 
                 rs9328048 
                 0.3673 
               
               
                   
                 1KG 
                 6:132523980 
                 rs728371 
                 rs728371 
                 0.3437 
               
               
                   
                 1KG 
                 6:160376153 
                 rs1867348 
                 rs1867348 
                 0.0986 
               
               
                   
                 1KG 
                 6:162467903 
                 chr6: 162467903 
                 chr6: 162467903 
                 0.0781 
               
               
                   
                 1KG 
                 6:31277268 
                 rs9366769 
                 rs9366769 
                 0.1984 
               
               
                   
                 1KG 
                 6:32011783 
                 rs9332739 
                 rs9332739 
                 0.0231 
               
               
                   
                 1KG 
                 6:32022159 
                 rs641153 
                 rs641153 
                 0.0528 
               
               
                   
                 1KG 
                 6:33503177 
                 rs9461856 
                 rs9461856 
                 0.4878 
               
               
                   
                 1KG 
                 6:43936560 
                 rs4711751 
                 rs4711751 
                 0.5352 
               
               
                   
                 1KG 
                 6:55456674 
                 rs4260755 
                 rs4260755 
                 0.3862 
               
               
                   
                 1KG 
                 6:57396889 
                 rs9475939 
                 rs9475939 
                 0.0283 
               
               
                   
                 1KG 
                 6:7063989 
                 rs11755724 
                 rs11755724 
                 0.3424 
               
               
                   
                 1KG 
                 6:7152544 
                 rs1360751 
                 rs1360751 
                 0.5508 
               
               
                   
                 1KG 
                 6:93573222 
                 rs2037156 
                 rs2037156 
                 0.2143 
               
               
                   
                 HM2 
                 7:14123511 
                 rs7783337 
                 rs7783337 
                 0.1519 
               
               
                   
                 1KG 
                 7:23550807 
                 rs10280782 
                 rs10280782 
                 0.1232 
               
               
                   
                 1KG 
                 7:27475356 
                 rs17155281 
                 rs17155281 
                 0.276 
               
               
                   
                 1KG 
                 7:35595154 
                 rs343718 
                 rs343718 
                 0.2884 
               
               
                   
                 1KG 
                 7:43880667 
                 rs2730613 
                 rs2730613 
                 0.3344 
               
               
                   
                 1KG 
                 7:54736904 
                 rs10225927 
                 rs10225927 
                 0.2159 
               
               
                   
                 1KG 
                 7:86076557 
                 rs1358395 
                 rs1358395 
                 0.2901 
               
               
                   
                 1KG 
                 8:123521501 
                 rs4282579 
                 rs4282579 
                 0.3444 
               
               
                   
                 1KG 
                 8:128550166 
                 rs10089310 
                 rs10089310 
                 0.1149 
               
               
                   
                 1KG 
                 8:136110326 
                 rs13253938 
                 rs13253938 
                 0.5278 
               
               
                   
                 1KG 
                 8:13715406 
                 rs1384044 
                 rs1384044 
                 0.5042 
               
               
                   
                 1KG 
                 8:139212254 
                 rs10103808 
                 rs10103808 
                 0.1148 
               
               
                   
                 1KG 
                 8:14247492 
                 rs10503493 
                 rs10503493 
                 0.0425 
               
               
                   
                 1KG 
                 8:19888502 
                 rs12678919 
                 rs12678919 
                 0.0989 
               
               
                   
                 1KG 
                 8:20081107 
                 rs2270637 
                 rs2270637 
                 0.1728 
               
               
                   
                 1KG 
                 8:23138916 
                 rs13278062 
                 rs13278062 
                 0.5369 
               
               
                   
                 1KG 
                 8:506479 
                 rs722782 
                 rs722782 
                 0.0841 
               
               
                   
                 HM2 
                 8:96819457 
                 rs6982567 
                 rs6982567 
                 0.2077 
               
               
                   
                 1KG 
                 9:106704122 
                 rs1883025 
                 rs1883025 
                 0.2564 
               
               
                   
                 1KG 
                 9:114121319 
                 rs10739343 
                 rs10739343 
                 0.2015 
               
               
                   
                 1KG 
                 9:15279578 
                 rs471364 
                 rs471364 
                 0.1118 
               
               
                   
                 1KG 
                 9:4536594 
                 rs10815017 
                 rs10815017 
                 0.2991 
               
               
                   
                   
               
             
          
           
               
                 REF 
                 hg_18_BP 
                 OldSNP 
                 F_EA_U 
                 INFO 
                 EA_OR 
                 P 
               
               
                   
               
               
                 1KG 
                 1:100166675 
                 chr1: 100166675 
                 0.0366 
                 0.9746 
                 1.3684 
                 0.0005929 
               
               
                 1KG 
                 1:163986967 
                 chr1: 163986967 
                 0.059 
                 1.0445 
                 0.7049 
                 0.00555 
               
               
                 1KG 
                 1:165795961 
                 rs1737478 
                 0.2262 
                 1.0175 
                 1.1357 
                 0.003573 
               
               
                 1KG 
                 1:185513773 
                 rs2453727 
                 0.492 
                 0.9109 
                 1.0017 
                 0.964 
               
               
                 1KG 
                 1:194925860 
                 rs1061170 
                 0.3713 
                 0.5729 
                 2.738975623 
                 5.638E−138 
               
               
                 1KG 
                 1:194963556 
                 rs1410996 
                 0.5794 
                 0.8946 
                 3.118178983 
                 2.147E−134 
               
               
                 1KG 
                 1:205461564 
                 rs1367068 
                 0.226 
                 0.8094 
                 0.713368526 
                 2.796E−07 
               
               
                 1KG 
                 1:205515927 
                 rs12040406 
                 0.094 
                 0.9597 
                 0.456183568 
                 2.786E−07 
               
               
                 1KG 
                 1:227122574 
                 rs6685751 
                 0.4657 
                 0.6907 
                 1.1607 
                 0.003299 
               
               
                 1KG 
                 1:228362314 
                 rs4846914 
                 0.3957 
                 0.1864 
                 1.040691019 
                 0.2946 
               
               
                 1KG 
                 1:247130153 
                 rs6587759 
                 0.051 
                 0.4828 
                 1.3373 
                 0.0003756 
               
               
                 1KG 
                 1:31101812 
                 rs2491146 
                 0.3933 
                 0.9737 
                 0.8641 
                 0.000358 
               
               
                 1KG 
                 1:5303445 
                 rs1326005 
                 0.4049 
                 0.9851 
                 0.9191 
                 0.03688 
               
               
                 1KG 
                 1:57219300 
                 rs1418473 
                 0.072 
                 0.9102 
                 1.221 
                 0.005179 
               
               
                 1KG 
                 1:57677552 
                 rs11207037 
                 0.2431 
                 0.9669 
                 1.0234367 
                 0.5953 
               
               
                 1KG 
                 1:79360392 
                 rs17408651 
                 0.1288 
                 0.9045 
                 0.8501 
                 0.01478 
               
               
                 1KG 
                 10:124204438 
                 rs10490924 
                 0.2058 
                 0.9371 
                 3.1865 
                  1.21E−144 
               
               
                 1KG 
                 10:19392088 
                 rs11596472 
                 0.0826 
                 0.9403 
                 1.150747986 
                 0.1779 
               
               
                 1KG 
                 10:24883792 
                 rs16924889 
                 0.0931 
                 0.8113 
                 0.9404 
                 0.3655 
               
               
                 1KG 
                 10:32036318 
                 rs2277252 
                 0.455 
                 0.9773 
                 1.1865 
                 0.00008953 
               
               
                 1KG 
                 10:3945290 
                 rs11592003 
                 0.1615 
                 0.7947 
                 0.819470622 
                 0.0001869 
               
               
                 1KG 
                 10:56380194 
                 rs61856267 
                 0.0946 
                 0.978 
                 1.354829969 
                 0.00004618 
               
               
                 1KG 
                 10:57479107 
                 chr10: 57479107 
                 0.1054 
                 0.7311 
                 1.1634 
                 0.01073 
               
               
                 1KG 
                 10:8226099 
                 rs2798832 
                 0.2403 
                 0.9089 
                 1.166 
                 0.0005466 
               
               
                 1KG 
                 10:88344492 
                 chr10: 88344492 
                 0.1406 
                 0.4875 
                 1.2144 
                 0.0002725 
               
               
                 1KG 
                 10:88396729 
                 rs2803544 
                 0.1335 
                 0.8953 
                 1.2022 
                 0.000592 
               
               
                 1KG 
                 10:92382787 
                 rs7094579 
                 0.0568 
                 0.6766 
                 0.753 
                 0.0009303 
               
               
                 1KG 
                 11:100149779 
                 rs625761 
                 0.2625 
                 0.9887 
                 0.863185153 
                 0.0009244 
               
               
                 1KG 
                 11:103362906 
                 rs12798294 
                 0.2959 
                 0.9432 
                 0.8706 
                 0.0009907 
               
               
                 1KG 
                 11:104185708 
                 chr11: 104185708 
                 0.0463 
                 0.5802 
                 1.7253 
                 0.01322 
               
               
                 1KG 
                 11:116154127 
                 rs964184 
                 0.1433 
                 1.0036 
                 0.963483958 
                 0.4885 
               
               
                 1KG 
                 11:1762440 
                 rs55911157 
                 0.1731 
                 0.9543 
                 0.7781 
                 0.000009621 
               
               
                 1KG 
                 11:1768072 
                 rs72850977 
                 0.1723 
                 0.9861 
                 0.7792 
                 0.000008946 
               
               
                 1KG 
                 11:32859894 
                 rs4755455 
                 0.1757 
                 0.5199 
                 0.9526 
                 0.3297 
               
               
                 1KG 
                 11:37597461 
                 rs10768315 
                 0.2971 
                 0.7687 
                 0.8472 
                 0.00007111 
               
               
                 1KG 
                 11:61327359 
                 rs174547 
                 0.3448 
                 0.9171 
                 0.952380952 
                 0.2107 
               
               
                 1KG 
                 11:73662041 
                 rs513683 
                 0.4611 
                 0.8833 
                 0.8991 
                 0.005903 
               
               
                 1KG 
                 12:108379551 
                 rs2338104 
                 0.5421 
                 0.9954 
                 0.956022945 
                 0.2264 
               
               
                 1KG 
                 12:11233234 
                 chr12: 11233234 
                 0.1392 
                 0.871 
                 1.1565 
                 0.04241 
               
               
                 1KG 
                 12:114010367 
                 rs11067403 
                 0.342 
                 0.6618 
                 0.871231922 
                 0.0005053 
               
               
                 1KG 
                 12:123850701 
                 rs5888 
                 0.5141 
                 0.6557 
                 1.002004008 
                 0.9593 
               
               
                 1KG 
                 12:19878442 
                 rs1492116 
                 0.2335 
                 0.8937 
                 0.842034355 
                 0.00013 
               
               
                 1KG 
                 12:2290505 
                 rs10848645 
                 0.3969 
                 0.739 
                 1.190617931 
                 0.00006143 
               
               
                 1KG 
                 12:45893566 
                 rs11183802 
                 0.0708 
                 0.9758 
                 1.3253 
                 0.001883 
               
               
                 1KG 
                 12:50881293 
                 rs7958529 
                 0.3494 
                 1.0147 
                 0.844951415 
                 0.0001293 
               
               
                 1KG 
                 12:80847264 
                 rs7973032 
                 0.0685 
                 0.996 
                 0.958864704 
                 0.5758 
               
               
                 1KG 
                 12:92165329 
                 rs7973431 
                 0.3168 
                 0.7038 
                 1.0087 
                 0.8331 
               
               
                 1KG 
                 13:105365389 
                 rs4771513 
                 0.1275 
                 0.9026 
                 0.949667616 
                 0.3845 
               
               
                 1KG 
                 13:30736688 
                 rs1912795 
                 0.4329 
                 1.0068 
                 1.1392 
                 0.0005884 
               
               
                 1KG 
                 13:78960018 
                 rs17071512 
                 0.1033 
                 0.9223 
                 0.805347507 
                 0.002856 
               
               
                 1KG 
                 13:83069357 
                 rs7317763 
                 0.4456 
                 0.8723 
                 1.0722 
                 0.06489 
               
               
                 1KG 
                 14:95216646 
                 rs8011890 
                 0.0828 
                 0.8743 
                 1.4427 
                 0.00003215 
               
               
                 1KG 
                 15:30811243 
                 rs3743105 
                 0.4211 
                 0.9872 
                 0.9607 
                 0.293 
               
               
                 1KG 
                 15:35201758 
                 chr15: 35201758 
                 0.1344 
                 1.0006 
                 1.3375 
                 0.00002486 
               
               
                 1KG 
                 15:35992085 
                 rs16965939 
                 0.1081 
                 0.9764 
                 0.6687 
                 0.00001622 
               
               
                 1KG 
                 15:40375218 
                 rs12908430 
                 0.0899 
                 0.9176 
                 0.6083 
                 0.0004389 
               
               
                 1KG 
                 15:47957127 
                 chr15: 47957127 
                 0.0115 
                 0.7763 
                 0.1281 
                 0.03299 
               
               
                 1KG 
                 15:56465804 
                 rs10468017 
                 0.2874 
                 0.9976 
                 0.8324 
                 0.00004595 
               
               
                 1KG 
                 15:56475172 
                 rs493258 
                 0.5286 
                 1.0005 
                 1.179106237 
                 0.00001198 
               
               
                 1KG 
                 15:59828725 
                 rs11854497 
                 0.1139 
                 0.9579 
                 0.825 
                 0.001868 
               
               
                 1KG 
                 15:87312556 
                 rs11854658 
                 0.3539 
                 0.8503 
                 0.859623485 
                 0.0001108 
               
               
                 1KG 
                 15:87314645 
                 rs11856826 
                 0.3733 
                 0.7294 
                 0.853096741 
                 0.00009204 
               
               
                 1KG 
                 16:11814579 
                 rs2024393 
                 0.1583 
                 0.9604 
                 1.0619 
                 0.3666 
               
               
                 1KG 
                 16:17310751 
                 chr16: 17310751 
                 0.1009 
                 0.8498 
                 0.763067531 
                 0.0001012 
               
               
                 1KG 
                 16:23091095 
                 rs4967980 
                 0.2253 
                 0.9635 
                 1.204093919 
                 0.0000362 
               
               
                 1KG 
                 16:55550825 
                 rs3764261 
                 0.3277 
                 0.6994 
                 1.1631 
                 0.0001162 
               
               
                 1KG 
                 16:66459571 
                 rs2271293 
                 0.1157 
                 0.7374 
                 1.0897 
                 0.1345 
               
               
                 1KG 
                 16:72289810 
                 rs2127740 
                 0.1138 
                 0.67 
                 1.2894 
                 0.000008169 
               
               
                 1KG 
                 16:74921678 
                 rs8053796 
                 0.2638 
                 0.9744 
                 1.1928 
                 0.0002414 
               
               
                 1KG 
                 16:74929641 
                 rs6564324 
                 0.2675 
                 0.5228 
                 1.197031362 
                 0.0001849 
               
               
                 1KG 
                 16:84929276 
                 rs12926103 
                 0.0573 
                 0.9309 
                 1.4308 
                 0.00003384 
               
               
                 1KG 
                 16:85846518 
                 rs3748391 
                 0.5459 
                 0.993 
                 0.8754 
                 0.0003254 
               
               
                 1KG 
                 17:45980827 
                 rs8076470 
                 0.3844 
                 1.0049 
                 1.1472 
                 0.0004619 
               
               
                 1KG 
                 17:72483712 
                 chr17: 72483712 
                 0.0572 
                 0.9544 
                 0.769882208 
                 0.07803 
               
               
                 1KG 
                 17:73838135 
                 rs16971055 
                 0.0876 
                 0.9963 
                 1.3213 
                 0.00524 
               
               
                 1KG 
                 17:77136846 
                 rs4073997 
                 0.2118 
                 0.8709 
                 1.1002 
                 0.5804 
               
               
                 1KG 
                 18:34111545 
                 rs8091635 
                 0.3485 
                 1.0123 
                 1.1987 
                 0.000006243 
               
               
                 1KG 
                 18:34125717 
                 rs17628762 
                 0.3426 
                 0.9375 
                 1.188 
                 0.000008979 
               
               
                 1KG 
                 18:36481096 
                 rs2469875 
                 0.4837 
                 0.9992 
                 0.995520159 
                 0.9027 
               
               
                 1KG 
                 18:45421212 
                 rs4939883 
                 0.1714 
                 0.2388 
                 1.0146 
                 0.7654 
               
               
                 1KG 
                 18:53934507 
                 rs529478 
                 0.5103 
                 0.9232 
                 0.832986256 
                 0.00004656 
               
               
                 1KG 
                 18:68641554 
                 rs11876415 
                 0.3703 
                 0.9964 
                 0.940203084 
                 0.205 
               
               
                 1KG 
                 18:72988032 
                 rs1789110 
                 0.3749 
                 0.9875 
                 1.201778632 
                 0.000003171 
               
               
                 1KG 
                 19:36639376 
                 rs2052572 
                 0.3141 
                 0.9939 
                 1.1729 
                 0.00009603 
               
               
                 1KG 
                 19:5792356 
                 rs3760775 
                 0.0679 
                 0.9104 
                 0.7243 
                 0.0001966 
               
               
                 HM2 
                 19:59425996 
                 rs7260457 
                 0.3736 
                 0.966 
                 0.7477 
                 0.004664 
               
               
                 1KG 
                 19:6669387 
                 rs2230199 
                 0.1926 
                 0.9598 
                 1.6842 
                 1.357E−18 
               
               
                 1KG 
                 19:8375738 
                 rs2967605 
                 0.1762 
                 0.9849 
                 1.0509 
                 0.3256 
               
               
                 1KG 
                 2:124751486 
                 rs9308649 
                 0.2092 
                 0.9488 
                 0.834724541 
                 0.0001473 
               
               
                 1KG 
                 2:180796214 
                 chr2: 180796214 
                 0.1957 
                 0.809 
                 0.8419 
                 0.0006251 
               
               
                 1KG 
                 2:189854831 
                 rs10207860 
                 0.0719 
                 0.9044 
                 0.9 
                 0.1687 
               
               
                 1KG 
                 2:20201501 
                 rs6531212 
                 0.3514 
                 0.5525 
                 0.8491 
                 0.00003021 
               
               
                 1KG 
                 2:44132778 
                 chr2: 44132778 
                 0.0756 
                 1.0232 
                 0.684415851 
                 0.0002569 
               
               
                 1KG 
                 2:71597893 
                 rs13402171 
                 0.091 
                 0.8994 
                 1.0004 
                 0.9956 
               
               
                 1KG 
                 2:76232489 
                 rs1851808 
                 0.3625 
                 1.0133 
                 1.149954002 
                 0.0003417 
               
               
                 1KG 
                 20:42475778 
                 rs1800961 
                 0.0314 
                 0.9294 
                 0.8286 
                 0.09321 
               
               
                 1KG 
                 20:44009909 
                 rs7679 
                 0.1865 
                 0.438 
                 0.943307235 
                 0.227 
               
               
                 1KG 
                 20:4486243 
                 rs958646 
                 0.087 
                 0.8446 
                 0.9867 
                 0.8419 
               
               
                 1KG 
                 20:56979160 
                 rs235195 
                 0.1251 
                 0.9237 
                 1.364 
                 0.002827 
               
               
                 HM2 
                 22:31414511 
                 rs9621532 
                 0.0512 
                 0.9988 
                 0.719838756 
                 0.00037321 
               
               
                 1KG 
                 22:36259705 
                 rs1079982 
                 0.065 
                 0.9484 
                 0.7054 
                 0.0001557 
               
               
                 1KG 
                 22:43172593 
                 rs135912 
                 0.2735 
                 0.9844 
                 0.951746455 
                 0.3149 
               
               
                 1KG 
                 22:47467676 
                 rs5771717 
                 0.1002 
                 0.9566 
                 1.1586 
                 0.1004 
               
               
                 1KG 
                 3:100878962 
                 rs13095226 
                 0.104 
                 0.9379 
                 1.224439819 
                 0.0004761 
               
               
                 1KG 
                 3:101053451 
                 rs7626245 
                 0.0727 
                 0.9804 
                 1.3399 
                 0.00003955 
               
               
                 1KG 
                 3:118210505 
                 rs1540819 
                 0.4345 
                 0.2953 
                 1.1303 
                 0.001249 
               
               
                 1KG 
                 3:119674993 
                 rs12637095 
                 0.2203 
                 0.8651 
                 0.836470096 
                 0.0001092 
               
               
                 1KG 
                 3:119681130 
                 rs1915098 
                 0.1655 
                 0.9078 
                 0.7983 
                 0.00002407 
               
               
                 1KG 
                 3:120558458 
                 rs9713311 
                 0.3765 
                 0.9709 
                 1.134558657 
                 0.0007681 
               
               
                 1KG 
                 3:130591125 
                 rs12632105 
                 0.1695 
                 0.94 
                 0.9737 
                 0.6286 
               
               
                 1KG 
                 3:154434339 
                 rs16822447 
                 0.1558 
                 0.6039 
                 0.848896435 
                 0.002918 
               
               
                 1KG 
                 3:156261403 
                 rs13094238 
                 0.1461 
                 0.6745 
                 0.745378652 
                 0.006705 
               
               
                 1KG 
                 3:163192835 
                 rs4256145 
                 0.3381 
                 0.1812 
                 0.843881857 
                 0.00002249 
               
               
                 1KG 
                 3:37504640 
                 rs11716363 
                 0.179 
                 0.8854 
                 1.0861 
                 0.105 
               
               
                 1KG 
                 3:53233464 
                 rs12632671 
                 0.0568 
                 0.2803 
                 1.4031 
                 0.0002466 
               
               
                 1KG 
                 3:71584585 
                 rs2135548 
                 0.2402 
                 0.7645 
                 1.173984503 
                 0.0001424 
               
               
                 1KG 
                 4:110878516 
                 rs10033900 
                 0.463 
                 0.919 
                 1.3144 
                 2.401E−11 
               
               
                 1KG 
                 4:128495772 
                 rs1443179 
                 0.0348 
                 0.5355 
                 1.7594 
                 0.001578 
               
               
                 1KG 
                 4:162971300 
                 rs17639345 
                 0.1466 
                 0.9682 
                 1.0405 
                 0.4416 
               
               
                 1KG 
                 4:165142286 
                 rs11736266 
                 0.5173 
                 0.9843 
                 1.051524711 
                 0.1999 
               
               
                 1KG 
                 4:182181154 
                 rs9997006 
                 0.3654 
                 0.3968 
                 1.2106 
                 0.0008115 
               
               
                 1KG 
                 4:23188024 
                 chr4: 23188024 
                 0.0389 
                 0.1399 
                 0.491 
                 0.002383 
               
               
                 1KG 
                 4:36840346 
                 rs2376241 
                 0.2423 
                 0.9059 
                 1.148 
                 0.001166 
               
               
                 1KG 
                 4:86877248 
                 rs28621471 
                 0.2481 
                 0.3957 
                 0.8532 
                 0.0008447 
               
               
                 1KG 
                 5:106936632 
                 rs164700 
                 0.142 
                 0.3956 
                 1.2085 
                 0.002048 
               
               
                 1KG 
                 5:113645446 
                 chr5: 113645446 
                 0.132 
                 0.9279 
                 1.208459215 
                 0.0006648 
               
               
                 1KG 
                 5:149749881 
                 chr5: 149749881 
                 0.0713 
                 0.2446 
                 1.2083 
                 0.006721 
               
               
                 1KG 
                 5:165133520 
                 chr5: 165133520 
                 0.1948 
                 0.98 
                 0.859328005 
                 0.00183 
               
               
                 1KG 
                 5:21309600 
                 rs2883171 
                 0.116 
                 0.9596 
                 1.322401481 
                 0.00001405 
               
               
                 1KG 
                 5:26212150 
                 chr5: 26212150 
                 0.0733 
                 0.6461 
                 0.705566923 
                 0.00001452 
               
               
                 1KG 
                 5:52621268 
                 rs251525 
                 0.3101 
                 0.1572 
                 1.147183664 
                 0.0008037 
               
               
                 1KG 
                 5:5291813 
                 rs7720497 
                 0.0546 
                 0.7188 
                 1.373249107 
                 0.0001015 
               
               
                 1KG 
                 5:61112540 
                 rs9291737 
                 0.4211 
                 0.7485 
                 0.863483292 
                 0.00009344 
               
               
                 1KG 
                 5:64292165 
                 rs10067691 
                 0.0594 
                 0.0401 
                 0.694 
                 0.0045671 
               
               
                 1KG 
                 5:74385314 
                 rs12520598 
                 0.0509 
                 0.8639 
                 0.7993 
                 0.03102 
               
               
                 1KG 
                 5:86468373 
                 rs2032794 
                 0.2108 
                 0.501 
                 1.053962901 
                 0.2518 
               
               
                 1KG 
                 6:109470664 
                 rs13192030 
                 0.0357 
                 0.9587 
                 0.727696114 
                 0.5968 
               
               
                 1KG 
                 6:116493827 
                 rs1999930 
                 0.3044 
                 0.2794 
                 0.8068 
                 3.133E−07 
               
               
                 1KG 
                 6:116529937 
                 rs509859 
                 0.4133 
                 0.9893 
                 0.8508 
                 0.00003054 
               
               
                 1KG 
                 6:116568331 
                 rs12204816 
                 0.224 
                 0.4444 
                 0.7488 
                 1.731E−07 
               
               
                 1KG 
                 6:116596243 
                 rs12196141 
                 0.2872 
                 0.9876 
                 0.797448166 
                 1.532E−07 
               
               
                 1KG 
                 6:1324870 
                 rs9328048 
                 0.395 
                 0.8669 
                 0.846 
                 0.0002311 
               
               
                 1KG 
                 6:132523980 
                 rs728371 
                 0.3145 
                 0.7359 
                 1.1821 
                 0.00005385 
               
               
                 1KG 
                 6:160376153 
                 rs1867348 
                 0.0801 
                 0.9686 
                 1.2525 
                 0.0005041 
               
               
                 1KG 
                 6:162467903 
                 chr6: 162467903 
                 0.09 
                 0.8867 
                 0.8001 
                 0.001774 
               
               
                 1KG 
                 6:31277268 
                 rs9366769 
                 0.2305 
                 0.4034 
                 0.81109579 
                 0.000005154 
               
               
                 1KG 
                 6:32011783 
                 rs9332739 
                 0.0447 
                 0.8879 
                 0.4463 
                 4.335E−12 
               
               
                 1KG 
                 6:32022159 
                 rs641153 
                 0.101 
                 0.6268 
                 0.461 
                 2.94E−22 
               
               
                 1KG 
                 6:33503177 
                 rs9461856 
                 0.5204 
                 0.9963 
                 0.8641 
                 0.00007769 
               
               
                 1KG 
                 6:43936560 
                 rs4711751 
                 0.5044 
                 0.9915 
                 1.2081 
                 0.0000218 
               
               
                 1KG 
                 6:55456674 
                 rs4260755 
                 0.3512 
                 0.9741 
                 1.152 
                 0.000255 
               
               
                 1KG 
                 6:57396889 
                 rs9475939 
                 0.0284 
                 0.9482 
                 1.297521733 
                 0.9806 
               
               
                 1KG 
                 6:7063989 
                 rs11755724 
                 0.3723 
                 0.9587 
                 0.878 
                 0.0006616 
               
               
                 1KG 
                 6:7152544 
                 rs1360751 
                 0.5208 
                 0.9758 
                 1.1507 
                 0.000209 
               
               
                 1KG 
                 6:93573222 
                 rs2037156 
                 0.1926 
                 0.711 
                 1.167951413 
                 0.001602 
               
               
                 HM2 
                 7:14123511 
                 rs7783337 
                 0.1375 
                 0.9119 
                 1.179941003 
                 0.002751 
               
               
                 1KG 
                 7:23550807 
                 rs10280782 
                 0.1513 
                 0.9646 
                 0.767754319 
                 0.000001593 
               
               
                 1KG 
                 7:27475356 
                 rs17155281 
                 0.2917 
                 0.92 
                 0.878580214 
                 0.01156 
               
               
                 1KG 
                 7:35595154 
                 rs343718 
                 0.3029 
                 0.5758 
                 0.9357 
                 0.1015 
               
               
                 1KG 
                 7:43880667 
                 rs2730613 
                 0.3525 
                 0.8741 
                 0.882378893 
                 0.001495 
               
               
                 1KG 
                 7:54736904 
                 rs10225927 
                 0.1905 
                 1.0039 
                 1.180637544 
                 0.0002957 
               
               
                 1KG 
                 7:86076557 
                 rs1358395 
                 0.3185 
                 0.9776 
                 0.8507 
                 0.0001186 
               
               
                 1KG 
                 8:123521501 
                 rs4282579 
                 0.3112 
                 0.9314 
                 1.166725003 
                 0.00007708 
               
               
                 1KG 
                 8:128550166 
                 rs10089310 
                 0.0961 
                 0.0677 
                 1.2349 
                 0.0004286 
               
               
                 1KG 
                 8:136110326 
                 rs13253938 
                 0.5635 
                 0.9637 
                 0.844808651 
                 0.00001831 
               
               
                 1KG 
                 8:13715406 
                 rs1384044 
                 0.5311 
                 0.0274 
                 0.8777 
                 0.0006033 
               
               
                 1KG 
                 8:139212254 
                 rs10103808 
                 0.0905 
                 1.011 
                 1.326259947 
                 0.000006651 
               
               
                 1KG 
                 8:14247492 
                 rs10503493 
                 0.055 
                 0.8234 
                 0.7705 
                 0.003472 
               
               
                 1KG 
                 8:19888502 
                 rs12678919 
                 0.101 
                 0.9593 
                 0.974753875 
                 0.6846 
               
               
                 1KG 
                 8:20081107 
                 rs2270637 
                 0.1999 
                 1.008 
                 0.818330606 
                 0.0000319 
               
               
                 1KG 
                 8:23138916 
                 rs13278062 
                 0.5138 
                 0.9277 
                 1.1804 
                 0.0006516 
               
               
                 1KG 
                 8:506479 
                 rs722782 
                 0.1055 
                 0.9723 
                 0.7698 
                 0.00004568 
               
               
                 HM2 
                 8:96819457 
                 rs6982567 
                 0.1912 
                 0.9911 
                 1.1905 
                 0.0006232 
               
               
                 1KG 
                 9:106704122 
                 rs1883025 
                 0.2784 
                 0.9172 
                 0.8697 
                 0.001275 
               
               
                 1KG 
                 9:114121319 
                 rs10739343 
                 0.2256 
                 0.9901 
                 0.8504 
                 0.0003545 
               
               
                 1KG 
                 9:15279578 
                 rs471364 
                 0.1143 
                 0.0001 
                 0.971722865 
                 0.6198 
               
               
                 1KG 
                 9:4536594 
                 rs10815017 
                 0.3153 
                 1.0083 
                 0.9327 
                 0.1325 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 7 
               
               
                   
               
             
             
               
                 REF 
                 hg_18_BP 
                 OldSNP 
                 A1 
                 A2 
                 FRQ_A(2594) 
                 FRQ_U(4134) 
                 OR 
                 SE 
               
               
                   
               
               
                 1KG 
                 10:124204438 
                 rs10490924 
                 T 
                 G 
                 0.4144 
                 0.2058 
                 3.1865 
                 0.0453 
               
               
                 1KG 
                 1:194925860 
                 rs1061170 
                 T 
                 C 
                 0.3909 
                 0.6287 
                 0.3651 
                 0.0403 
               
               
                 1KG 
                 1:194963556 
                 rs1410996 
                 A 
                 G 
                 0.2004 
                 0.4206 
                 0.3207 
                 0.0461 
               
               
                 1KG 
                 6:32022159 
                 rs641153 
                 A 
                 G 
                 0.0528 
                 0.101 
                 0.461 
                 0.0798 
               
               
                 1KG 
                 19:6669387 
                 rs2230199 
                 C 
                 G 
                 0.2439 
                 0.1926 
                 1.6842 
                 0.0592 
               
               
                 1KG 
                 6:32011783 
                 rs9332739 
                 C 
                 G 
                 0.0231 
                 0.0447 
                 0.4463 
                 0.1165 
               
               
                 1KG 
                 4:110878516 
                 rs10033900 
                 T 
                 C 
                 0.5205 
                 0.463 
                 1.3144 
                 0.0409 
               
               
                 1KG 
                 6:116596243 
                 rs12196141 
                 A 
                 G 
                 0.7543 
                 0.7128 
                 1.254 
                 0.0431 
               
               
                 1KG 
                 6:116568331 
                 rs12204816 
                 T 
                 C 
                 0.1906 
                 0.224 
                 0.7488 
                 0.0553 
               
               
                 1KG 
                 1:205515927 
                 rs12040406 
                 T 
                 C 
                 0.9174 
                 0.906 
                 2.1921 
                 0.1528 
               
               
                 1KG 
                 18:34125717 
                 rs17628762 
                 A 
                 C 
                 0.3824 
                 0.3426 
                 1.188 
                 0.0388 
               
               
                 1KG 
                 11:1762440 
                 rs55911157 
                 T 
                 C 
                 0.1489 
                 0.1731 
                 0.7781 
                 0.0567 
               
               
                 1KG 
                 15:56475172 
                 rs493258 
                 T 
                 C 
                 0.4318 
                 0.4714 
                 0.8481 
                 0.0376 
               
               
                 1KG 
                 6:116529937 
                 rs509859 
                 T 
                 G 
                 0.3742 
                 0.4133 
                 0.8508 
                 0.0388 
               
               
                 1KG 
                 15:56465804 
                 rs10468017 
                 T 
                 C 
                 0.2564 
                 0.2874 
                 0.8324 
                 0.045 
               
               
                 1KG 
                 8:123521501 
                 rs4282579 
                 A 
                 G 
                 0.6556 
                 0.6888 
                 0.8571 
                 0.039 
               
               
                 1KG 
                 15:87314645 
                 rs11856826 
                 T 
                 C 
                 0.6577 
                 0.6267 
                 1.1722 
                 0.0406 
               
               
                 1KG 
                 3:119674993 
                 rs12637095 
                 A 
                 T 
                 0.8045 
                 0.7797 
                 1.1955 
                 0.0462 
               
               
                 1KG 
                 16:55550825 
                 rs3764261 
                 A 
                 C 
                 0.36 
                 0.3277 
                 1.1631 
                 0.0392 
               
               
                 1KG 
                 16:74929641 
                 rs6564324 
                 A 
                 G 
                 0.7163 
                 0.7325 
                 0.8354 
                 0.0481 
               
               
                 1KG 
                 16:85846518 
                 rs3748391 
                 T 
                 G 
                 0.518 
                 0.5459 
                 0.8754 
                 0.037 
               
               
                 1KG 
                 9:114121319 
                 rs10739343 
                 A 
                 G 
                 0.2015 
                 0.2256 
                 0.8504 
                 0.0454 
               
               
                 HM2 
                 22:31414511 
                 rs9621532 
                 A 
                 C 
                 0.9634 
                 0.9488 
                 1.3892 
                 0.0924 
               
               
                 1KG 
                 8:128550166 
                 rs10089310 
                 A 
                 T 
                 0.1149 
                 0.0961 
                 1.2349 
                 0.0599 
               
               
                 1KG 
                 3:100878962 
                 rs13095226 
                 T 
                 C 
                 0.8772 
                 0.896 
                 0.8167 
                 0.0579 
               
               
                 1KG 
                 10:88396729 
                 rs2803544 
                 A 
                 T 
                 0.1528 
                 0.1335 
                 1.2022 
                 0.0536 
               
               
                 1KG 
                 6:7063989 
                 rs11755724 
                 A 
                 G 
                 0.3424 
                 0.3723 
                 0.878 
                 0.0382 
               
               
                 1KG 
                 4:182181154 
                 rs9997006 
                 T 
                 G 
                 0.3841 
                 0.3654 
                 1.2106 
                 0.0571 
               
               
                 1KG 
                 9:106704122 
                 rs1883025 
                 T 
                 C 
                 0.2564 
                 0.2784 
                 0.8697 
                 0.0434 
               
               
                 1KG 
                 15:59828725 
                 rs11854497 
                 A 
                 G 
                 0.1036 
                 0.1139 
                 0.825 
                 0.0618 
               
               
                 1KG 
                 1:5303445 
                 rs1326005 
                 A 
                 G 
                 0.3841 
                 0.4049 
                 0.9191 
                 0.0404 
               
               
                 1KG 
                 13:83069357 
                 rs7317763 
                 T 
                 C 
                 0.4613 
                 0.4456 
                 1.0722 
                 0.0378 
               
               
                 1KG 
                 20:42475778 
                 rs1800961 
                 T 
                 C 
                 0.0264 
                 0.0314 
                 0.8286 
                 0.112 
               
               
                 1KG 
                 3:37504640 
                 rs11716363 
                 T 
                 C 
                 0.1892 
                 0.179 
                 1.0861 
                 0.0509 
               
               
                 1KG 
                 9:4536594 
                 rs10815017 
                 T 
                 C 
                 0.2991 
                 0.3153 
                 0.9327 
                 0.0463 
               
               
                 1KG 
                 16:66459571 
                 rs2271293 
                 A 
                 G 
                 0.1249 
                 0.1157 
                 1.0897 
                 0.0574 
               
               
                 1KG 
                 2:189854831 
                 rs10207860 
                 T 
                 C 
                 0.0682 
                 0.0719 
                 0.9 
                 0.0765 
               
               
                 1KG 
                 4:165142286 
                 rs11736266 
                 T 
                 C 
                 0.478 
                 0.4827 
                 0.951 
                 0.0392 
               
               
                 1KG 
                 18:68641554 
                 rs11876415 
                 T 
                 C 
                 0.6298 
                 0.6297 
                 1.0636 
                 0.0486 
               
               
                 1KG 
                 11:61327359 
                 rs174547 
                 T 
                 C 
                 0.666 
                 0.6552 
                 1.05 
                 0.039 
               
               
                 1KG 
                 12:108379551 
                 rs2338104 
                 C 
                 G 
                 0.4627 
                 0.4579 
                 1.046 
                 0.0372 
               
               
                 1KG 
                 20:44009909 
                 rs7679 
                 T 
                 C 
                 0.8196 
                 0.8135 
                 1.0601 
                 0.0483 
               
               
                 1KG 
                 5:86468373 
                 rs2032794 
                 T 
                 C 
                 0.7796 
                 0.7892 
                 0.9488 
                 0.0458 
               
               
                 1KG 
                 15:30811243 
                 rs3743105 
                 T 
                 C 
                 0.4142 
                 0.4211 
                 0.9607 
                 0.0381 
               
               
                 1KG 
                 1:228362314 
                 rs4846914 
                 A 
                 G 
                 0.5938 
                 0.6043 
                 0.9609 
                 0.038 
               
               
                 1KG 
                 19:8375738 
                 rs2967605 
                 T 
                 C 
                 0.1811 
                 0.1762 
                 1.0509 
                 0.0505 
               
               
                 1KG 
                 11:32859894 
                 rs4755455 
                 C 
                 G 
                 0.1684 
                 0.1757 
                 0.9526 
                 0.0498 
               
               
                 1KG 
                 10:24883792 
                 rs16924889 
                 A 
                 G 
                 0.0865 
                 0.0931 
                 0.9404 
                 0.0679 
               
               
                 1KG 
                 13:105365389 
                 rs4771513 
                 T 
                 C 
                 0.8738 
                 0.8725 
                 1.053 
                 0.0594 
               
               
                 1KG 
                 4:162971300 
                 rs17639345 
                 A 
                 G 
                 0.1539 
                 0.1466 
                 1.0405 
                 0.0515 
               
               
                 1KG 
                 11:116154127 
                 rs964184 
                 C 
                 G 
                 0.862 
                 0.8567 
                 1.0379 
                 0.0538 
               
               
                 1KG 
                 12:80847264 
                 rs7973032 
                 A 
                 G 
                 0.9291 
                 0.9315 
                 1.0429 
                 0.075 
               
               
                 1KG 
                 1:57677552 
                 rs11207037 
                 A 
                 G 
                 0.7507 
                 0.7569 
                 0.9771 
                 0.0436 
               
               
                 1KG 
                 9:15279578 
                 rs471364 
                 T 
                 C 
                 0.8882 
                 0.8857 
                 1.0291 
                 0.0578 
               
               
                 1KG 
                 8:19888502 
                 rs12678919 
                 A 
                 G 
                 0.9011 
                 0.899 
                 1.0259 
                 0.0629 
               
               
                 1KG 
                 18:45421212 
                 rs4939883 
                 T 
                 C 
                 0.1743 
                 0.1714 
                 1.0146 
                 0.0486 
               
               
                 1KG 
                 12:92165329 
                 rs7973431 
                 T 
                 C 
                 0.3164 
                 0.3168 
                 1.0087 
                 0.0412 
               
               
                 1KG 
                 20:4486243 
                 rs958646 
                 C 
                 G 
                 0.0838 
                 0.087 
                 0.9867 
                 0.0671 
               
               
                 1KG 
                 18:36481096 
                 rs2469875 
                 A 
                 G 
                 0.5168 
                 0.5163 
                 1.0045 
                 0.037 
               
               
                 1KG 
                 12:123850701 
                 rs5888 
                 A 
                 G 
                 0.4889 
                 0.4859 
                 0.998 
                 0.0387 
               
               
                 1KG 
                 1:185513773 
                 rs2453727 
                 T 
                 C 
                 0.4977 
                 0.492 
                 1.0017 
                 0.0371 
               
               
                 1KG 
                 6:57396889 
                 rs9475939 
                 T 
                 C 
                 0.9717 
                 0.9716 
                 0.7707 
                 10.7214 
               
               
                 1KG 
                 2:71597893 
                 rs13402171 
                 T 
                 C 
                 0.0904 
                 0.091 
                 1.0004 
                 0.064 
               
               
                   
               
             
          
           
               
                 REF 
                 hg_18_BP 
                 OldSNP 
                 P 
                 EA 
                 Z 
                 EA_OR 
               
               
                   
               
               
                 1KG 
                 10:124204438 
                 rs10490924 
                  1.21E−144 
                 T 
                 25.60903658 
                 3.1865 
               
               
                 1KG 
                 1:194925860 
                 rs1061170 
                  5.638E−138 
                 C 
                 25.00323274 
                 2.738975623 
               
               
                 1KG 
                 1:194963556 
                 rs1410996 
                  2.147E−134 
                 G 
                 24.67181558 
                 3.118178983 
               
               
                 1KG 
                 6:32022159 
                 rs641153 
                  2.94E−22 
                 A 
                 −9.702569373 
                 0.461 
               
               
                 1KG 
                 19:6669387 
                 rs2230199 
                 1.357E−18 
                 C 
                 8.800919225 
                 1.6842 
               
               
                 1KG 
                 6:32011783 
                 rs9332739 
                 4.335E−12 
                 C 
                 −6.925806065 
                 0.4463 
               
               
                 1KG 
                 4:110878516 
                 rs10033900 
                 2.401E−11 
                 T 
                 6.679291601 
                 1.3144 
               
               
                 1KG 
                 6:116596243 
                 rs12196141 
                 1.532E−07 
                 G 
                 −5.248671475 
                 0.797448166 
               
               
                 1KG 
                 6:116568331 
                 rs12204816 
                 1.731E−07 
                 T 
                 −5.226124315 
                 0.7488 
               
               
                 1KG 
                 1:205515927 
                 rs12040406 
                 2.786E−07 
                 C 
                 −5.137376796 
                 0.456183568 
               
               
                 1KG 
                 18:34125717 
                 rs17628762 
                 0.000008979 
                 A 
                 4.440404368 
                 1.188 
               
               
                 1KG 
                 11:1762440 
                 rs55911157 
                 0.000009621 
                 T 
                 −4.425520544 
                 0.7781 
               
               
                 1KG 
                 15:56475172 
                 rs493258 
                 0.00001198 
                 C 
                 4.377951501 
                 1.179106237 
               
               
                 1KG 
                 6:116529937 
                 rs509859 
                 0.00003054 
                 T 
                 −4.169401925 
                 0.8508 
               
               
                 1KG 
                 15:56465804 
                 rs10468017 
                 0.00004595 
                 T 
                 −4.075325644 
                 0.8324 
               
               
                 1KG 
                 8:123521501 
                 rs4282579 
                 0.00007708 
                 G 
                 3.953302156 
                 1.166725003 
               
               
                 1KG 
                 15:87314645 
                 rs11856826 
                 0.00009204 
                 C 
                 −3.910671187 
                 0.853096741 
               
               
                 1KG 
                 3:119674993 
                 rs12637095 
                 0.0001092 
                 T 
                 −3.869184471 
                 0.836470096 
               
               
                 1KG 
                 16:55550825 
                 rs3764261 
                 0.0001162 
                 A 
                 3.85400757 
                 1.1631 
               
               
                 1KG 
                 16:74929641 
                 rs6564324 
                 0.0001849 
                 G 
                 3.738801021 
                 1.197031362 
               
               
                 1KG 
                 16:85846518 
                 rs3748391 
                 0.0003254 
                 T 
                 −3.594191857 
                 0.8754 
               
               
                 1KG 
                 9:114121319 
                 rs10739343 
                 0.0003545 
                 A 
                 −3.571826678 
                 0.8504 
               
               
                 HM2 
                 22:31414511 
                 rs9621532 
                 0.0003732 
                 C 
                 −3.558344238 
                 0.719838756 
               
               
                 1KG 
                 8:128550166 
                 rs10089310 
                 0.0004286 
                 A 
                 3.521816937 
                 1.2349 
               
               
                 1KG 
                 3:100878962 
                 rs13095226 
                 0.0004761 
                 C 
                 3.493854735 
                 1.224439819 
               
               
                 1KG 
                 10:88396729 
                 rs2803544 
                 0.000592 
                 A 
                 3.435253392 
                 1.2022 
               
               
                 1KG 
                 6:7063989 
                 rs11755724 
                 0.0006616 
                 A 
                 −3.405016732 
                 0.878 
               
               
                 1KG 
                 4:182181154 
                 rs9997006 
                 0.0008115 
                 T 
                 3.3488422 
                 1.2106 
               
               
                 1KG 
                 9:106704122 
                 rs1883025 
                 0.001275 
                 T 
                 −3.221548233 
                 0.8697 
               
               
                 1KG 
                 15:59828725 
                 rs11854497 
                 0.001868 
                 A 
                 −3.110453982 
                 0.825 
               
               
                 1KG 
                 1:5303445 
                 rs1326005 
                 0.03688 
                 A 
                 −2.087089998 
                 0.9191 
               
               
                 1KG 
                 13:83069357 
                 rs7317763 
                 0.06489 
                 T 
                 1.846015189 
                 1.0722 
               
               
                 1KG 
                 20:42475778 
                 rs1800961 
                 0.09321 
                 T 
                 −1.678702697 
                 0.8286 
               
               
                 1KG 
                 3:37504640 
                 rs11716363 
                 0.105 
                 T 
                 1.621082251 
                 1.0861 
               
               
                 1KG 
                 9:4536594 
                 rs10815017 
                 0.1325 
                 T 
                 −1.504316083 
                 0.9327 
               
               
                 1KG 
                 16:66459571 
                 rs2271293 
                 0.1345 
                 A 
                 1.496589899 
                 1.0897 
               
               
                 1KG 
                 2:189854831 
                 rs10207860 
                 0.1687 
                 T 
                 −1.376392981 
                 0.9 
               
               
                 1KG 
                 4:165142286 
                 rs11736266 
                 0.1999 
                 C 
                 1.281836521 
                 1.051524711 
               
               
                 1KG 
                 18:68641554 
                 rs11876415 
                 0.205 
                 C 
                 −1.267434417 
                 0.940203084 
               
               
                 1KG 
                 11:61327359 
                 rs174547 
                 0.2107 
                 C 
                 −1.251642941 
                 0.952380952 
               
               
                 1KG 
                 12:108379551 
                 rs2338104 
                 0.2264 
                 G 
                 −1.209684447 
                 0.956022945 
               
               
                 1KG 
                 20:44009909 
                 rs7679 
                 0.227 
                 C 
                 −1.20812288 
                 0.943307235 
               
               
                 1KG 
                 5:86468373 
                 rs2032794 
                 0.2518 
                 C 
                 1.145988284 
                 1.053962901 
               
               
                 1KG 
                 15:30811243 
                 rs3743105 
                 0.293 
                 T 
                 −1.051563198 
                 0.9607 
               
               
                 1KG 
                 1:228362314 
                 rs4846914 
                 0.2946 
                 G 
                 1.048083799 
                 1.040691019 
               
               
                 1KG 
                 19:8375738 
                 rs2967605 
                 0.3256 
                 T 
                 0.983015114 
                 1.0509 
               
               
                 1KG 
                 11:32859894 
                 rs4755455 
                 0.3297 
                 C 
                 −0.974718326 
                 0.9526 
               
               
                 1KG 
                 10:24883792 
                 rs16924889 
                 0.3655 
                 A 
                 −0.904934667 
                 0.9404 
               
               
                 1KG 
                 13:105365389 
                 rs4771513 
                 0.3845 
                 C 
                 −0.869634825 
                 0.949667616 
               
               
                 1KG 
                 4:162971300 
                 rs17639345 
                 0.4416 
                 A 
                 0.769494177 
                 1.0405 
               
               
                 1KG 
                 11:116154127 
                 rs964184 
                 0.4885 
                 G 
                 −0.692696557 
                 0.963483958 
               
               
                 1KG 
                 12:80847264 
                 rs7973032 
                 0.5758 
                 G 
                 −0.559530092 
                 0.958864704 
               
               
                 1KG 
                 1:57677552 
                 rs11207037 
                 0.5953 
                 G 
                 0.531171414 
                 1.0234367 
               
               
                 1KG 
                 9:15279578 
                 rs471364 
                 0.6198 
                 C 
                 −0.496133819 
                 0.971722865 
               
               
                 1KG 
                 8:19888502 
                 rs12678919 
                 0.6846 
                 G 
                 −0.406194085 
                 0.974753875 
               
               
                 1KG 
                 18:45421212 
                 rs4939883 
                 0.7654 
                 T 
                 0.298397234 
                 1.0146 
               
               
                 1KG 
                 12:92165329 
                 rs7973431 
                 0.8331 
                 T 
                 0.21072739 
                 1.0087 
               
               
                 1KG 
                 20:4486243 
                 rs958646 
                 0.8419 
                 C 
                 −0.199463746 
                 0.9867 
               
               
                 1KG 
                 18:36481096 
                 rs2469875 
                 0.9027 
                 G 
                 −0.122251299 
                 0.995520159 
               
               
                 1KG 
                 12:123850701 
                 rs5888 
                 0.9593 
                 G 
                 0.051032027 
                 1.002004008 
               
               
                 1KG 
                 1:185513773 
                 rs2453727 
                 0.964 
                 T 
                 0.045134628 
                 1.0017 
               
               
                 1KG 
                 6:57396889 
                 rs9475939 
                 0.9806 
                 C 
                 0.02431669 
                 1.297521733 
               
               
                 1KG 
                 2:71597893 
                 rs13402171 
                 0.9956 
                 T 
                 0.00551461 
                 1.0004 
               
               
                   
               
             
          
           
               
                   
                 REF 
                 hg_18_BP 
                 OldSNP 
                 ci− 
                 ci+ 
               
               
                   
                   
               
               
                   
                 1KG 
                 10:124204438 
                 rs10490924 
                 2.915773499 
                 3.482363172 
               
               
                   
                 1KG 
                 1:194925860 
                 rs1061170 
                 0.337371025 
                 0.395108057 
               
               
                   
                 1KG 
                 1:194963556 
                 rs1410996 
                 0.292993407 
                 0.351026636 
               
               
                   
                 1KG 
                 6:32022159 
                 rs641153 
                 0.394251899 
                 0.539048767 
               
               
                   
                 1KG 
                 19:6669387 
                 rs2230199 
                 1.49969038 
                 1.891410172 
               
               
                   
                 1KG 
                 6:32011783 
                 rs9332739 
                 0.355189472 
                 0.560781514 
               
               
                   
                 1KG 
                 4:110878516 
                 rs10033900 
                 1.213145154 
                 1.424106056 
               
               
                   
                 1KG 
                 6:116596243 
                 rs12196141 
                 1.152418114 
                 1.364535997 
               
               
                   
                 1KG 
                 6:116568331 
                 rs12204816 
                 0.671882803 
                 0.834522684 
               
               
                   
                 1KG 
                 1:205515927 
                 rs12040406 
                 1.624779296 
                 2.957510859 
               
               
                   
                 1KG 
                 18:34125717 
                 rs17628762 
                 1.101004804 
                 1.281869066 
               
               
                   
                 1KG 
                 11:1762440 
                 rs55911157 
                 0.696259928 
                 0.869559751 
               
               
                   
                 1KG 
                 15:56475172 
                 rs493258 
                 0.787845932 
                 0.912962269 
               
               
                   
                 1KG 
                 6:116529937 
                 rs509859 
                 0.78849738 
                 0.918025422 
               
               
                   
                 1KG 
                 15:56465804 
                 rs10468017 
                 0.762126913 
                 0.9091527251 
               
               
                   
                 1KG 
                 8:123521501 
                 rs4282579 
                 0.794024723 
                 0.925185815 
               
               
                   
                 1KG 
                 15:87314645 
                 rs11856826 
                 1.082535879 
                 1.269290807 
               
               
                   
                 1KG 
                 3:119674993 
                 rs12637095 
                 1.092001781 
                 1.308807619 
               
               
                   
                 1KG 
                 16:55550825 
                 rs3764261 
                 1.077083424 
                 1.255985916 
               
               
                   
                 1KG 
                 16:74929641 
                 rs6564324 
                 0.760240364 
                 0.917990142 
               
               
                   
                 1KG 
                 16:85846518 
                 rs3748391 
                 0.814163271 
                 0.941242607 
               
               
                   
                 1KG 
                 9:114121319 
                 rs10739343 
                 0.777997124 
                 0.929540917 
               
               
                   
                 HM2 
                 22:31414511 
                 rs9621532 
                 1.15907705 
                 1.665011519 
               
               
                   
                 1KG 
                 8:128550166 
                 rs10089310 
                 1.098105031 
                 1.38873602 
               
               
                   
                 1KG 
                 3:100878962 
                 rs13095226 
                 0.729083182 
                 0.914846078 
               
               
                   
                 1KG 
                 10:88396729 
                 rs2803544 
                 1.08230953 
                 1.335371074 
               
               
                   
                 1KG 
                 6:7063989 
                 rs11755724 
                 0.814663051 
                 0.946261155 
               
               
                   
                 1KG 
                 4:182181154 
                 rs9997006 
                 1.082420898 
                 1.353957932 
               
               
                   
                 1KG 
                 9:106704122 
                 rs1883025 
                 0.79877901 
                 0.946917834 
               
               
                   
                 1KG 
                 15:59828725 
                 rs11854497 
                 0.730884457 
                 0.931234743 
               
               
                   
                 1KG 
                 1:5303445 
                 rs1326005 
                 0.84912884 
                 0.994837026 
               
               
                   
                 1KG 
                 13:83069357 
                 rs7317763 
                 0.99563417 
                 1.154653862 
               
               
                   
                 1KG 
                 20:42475778 
                 rs1800961 
                 0.665286337 
                 1.032003698 
               
               
                   
                 1KG 
                 3:37504640 
                 rs11716363 
                 0.982975875 
                 1.200042891 
               
               
                   
                 1KG 
                 9:4536594 
                 rs10815017 
                 0.851786242 
                 1.021300001 
               
               
                   
                 1KG 
                 16:66459571 
                 rs2271293 
                 0.973749134 
                 1.219457916 
               
               
                   
                 1KG 
                 2:189854831 
                 rs10207860 
                 0.774683658 
                 1.045588081 
               
               
                   
                 1KG 
                 4:165142286 
                 rs11736266 
                 0.880669191 
                 1.026947473 
               
               
                   
                 1KG 
                 18:68641554 
                 rs11876415 
                 0.966961479 
                 1.169896614 
               
               
                   
                 1KG 
                 11:61327359 
                 rs174547 
                 0.972728922 
                 1.133409293 
               
               
                   
                 1KG 
                 12:108379551 
                 rs2338104 
                 0.97244804 
                 1.125115127 
               
               
                   
                 1KG 
                 20:44009909 
                 rs7679 
                 0.964346358 
                 1.165361388 
               
               
                   
                 1KG 
                 5:86468373 
                 rs2032794 
                 0.867339108 
                 1.037911737 
               
               
                   
                 1KG 
                 15:30811243 
                 rs3743105 
                 0.89157199 
                 1.035187849 
               
               
                   
                 1KG 
                 1:228362314 
                 rs4846914 
                 0.8919324 
                 1.035200436 
               
               
                   
                 1KG 
                 19:8375738 
                 rs2967605 
                 0.951864049 
                 1.160240069 
               
               
                   
                 1KG 
                 11:32859894 
                 rs4755455 
                 0.864012372 
                 1.050270562 
               
               
                   
                 1KG 
                 10:24883792 
                 rs16924889 
                 0.823218219 
                 1.074262133 
               
               
                   
                 1KG 
                 13:105365389 
                 rs4771513 
                 0.937272922 
                 1.183016146 
               
               
                   
                 1KG 
                 4:162971300 
                 rs17639345 
                 0.940598755 
                 1.151011783 
               
               
                   
                 1KG 
                 11:116154127 
                 rs964184 
                 0.934028284 
                 1.153323116 
               
               
                   
                 1KG 
                 12:80847264 
                 rs7973032 
                 0.900329289 
                 1.208047348 
               
               
                   
                 1KG 
                 1:57677552 
                 rs11207037 
                 0.897069196 
                 1.064270643 
               
               
                   
                 1KG 
                 9:15279578 
                 rs471364 
                 0.91887667 
                 1.152545107 
               
               
                   
                 1KG 
                 8:19888502 
                 rs12678919 
                 0.906908493 
                 1.160503864 
               
               
                   
                 1KG 
                 18:45421212 
                 rs4939883 
                 0.922413611 
                 1.115999534 
               
               
                   
                 1KG 
                 12:92165329 
                 rs7973431 
                 0.930447499 
                 1.093533693 
               
               
                   
                 1KG 
                 20:4486243 
                 rs958646 
                 0.865104269 
                 1.12538676 
               
               
                   
                 1KG 
                 18:36481096 
                 rs2469875 
                 0.934232358 
                 1.080052775 
               
               
                   
                 1KG 
                 12:123850701 
                 rs5888 
                 0.925099479 
                 1.076645294 
               
               
                   
                 1KG 
                 1:185513773 
                 rs2453727 
                 0.931445644 
                 1.077253295 
               
               
                   
                 1KG 
                 6:57396889 
                 rs9475939 
                 5.76296E−10 
                 1030683399 
               
               
                   
                 1KG 
                 2:71597893 
                 rs13402171 
                 0.882461533 
                 1.134100607 
               
               
                   
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
               
               
             
               
               
               
               
               
               
             
           
               
                 TABLE 8 
               
               
                   
               
             
             
               
                 REF 
                 hg_18_BP 
                 Gene (nearby) 
                 SNP 
                 A1 
                 A2 
                 FRQ_A(2594) 
                 FRQ_U(4134) 
               
               
                   
               
               
                 1KG 
                 8:123521501 
                 ZHX2 
                 rs4282579 
                 A 
                 G 
                 0.6556 
                 0.6888 
               
               
                 1KG 
                 15:87314645 
                 MFGE8|ABHD2 
                 rs11856826 
                 T 
                 C 
                 0.6577 
                 0.6267 
               
               
                 1KG 
                 3:119674993 
                 IGSF11 
                 rs12637095 
                 A 
                 T 
                 0.8045 
                 0.7797 
               
               
                 1KG 
                 16:85846518 
                 LOC730018 
                 rs3748391 
                 T 
                 G 
                 0.518 
                 0.5459 
               
               
                 1KG 
                 8:128550166 
                 POU5F1B 
                 rs10089310 
                 A 
                 T 
                 0.1149 
                 0.0961 
               
               
                 1KG 
                 10:88396729 
                 OPN4|RPL7AP8 
                 rs2803544 
                 A 
                 T 
                 0.1528 
                 0.1335 
               
               
                 1KG 
                 4:182181154 
                 LINC00290 
                 rs9997006 
                 T 
                 G 
                 0.3841 
                 0.3654 
               
               
                 1KG 
                 15:59828725 
                 VPS13C 
                 rs11854497 
                 A 
                 G 
                 0.1036 
                 0.1139 
               
               
                 1KG 
                 1:205515927 
                 CD55|C4BPAP2 
                 rs12040406 
                 T 
                 C 
                 0.9174 
                 0.906 
               
               
                 1KG 
                 18:34125717 
                 CELF4 
                 rs17628762 
                 A 
                 C 
                 0.3824 
                 0.3426 
               
               
                 1KG 
                 16:74929641 
                 CNTNAP4 
                 rs6564324 
                 A 
                 G 
                 0.7163 
                 0.7325 
               
               
                 1KG 
                 11:1762440 
                 CTSD 
                 rs55911157 
                 T 
                 C 
                 0.1489 
                 0.1731 
               
               
                 1KG 
                 9:114121319 
                 ROD1 
                 rs10739343 
                 A 
                 G 
                 0.2015 
                 0.2256 
               
               
                   
               
             
          
           
               
                 REF 
                 hg_18_BP 
                 Gene (nearby) 
                 OR 
                 SE 
                 P 
                 EA 
                 Z 
               
               
                   
               
               
                 1KG 
                 8:123521501 
                 ZHX2 
                 0.8571 
                 0.039 
                 0.00007708 
                 G 
                 3.953302156 
               
               
                 1KG 
                 15:87314645 
                 MFGE8|ABHD2 
                 1.1722 
                 0.0406 
                 0.00009204 
                 C 
                 −3.910671187 
               
               
                 1KG 
                 3:119674993 
                 IGSF11 
                 1.1955 
                 0.0462 
                 0.0001092 
                 T 
                 −3.869184471 
               
               
                 1KG 
                 16:85846518 
                 LOC730018 
                 0.8754 
                 0.037 
                 0.0003254 
                 T 
                 −3.594191857 
               
               
                 1KG 
                 8:128550166 
                 POU5F1B 
                 1.2349 
                 0.0599 
                 0.0004286 
                 A 
                 3.521816937 
               
               
                 1KG 
                 10:88396729 
                 OPN4|RPL7AP8 
                 1.2022 
                 0.0536 
                 0.000592 
                 A 
                 3.435253392 
               
               
                 1KG 
                 4:182181154 
                 LINC00290 
                 1.2106 
                 0.0571 
                 0.0008115 
                 T 
                 3.3488422 
               
               
                 1KG 
                 15:59828725 
                 VPS13C 
                 0.825 
                 0.0618 
                 0.001868 
                 A 
                 −3.110453982 
               
               
                 1KG 
                 1:205515927 
                 CD55|C4BPAP2 
                 2.1921 
                 0.1528 
                 2.786E−07 
                 C 
                 −5.137376796 
               
               
                 1KG 
                 18:34125717 
                 CELF4 
                 1.188 
                 0.0388 
                 0.000008979 
                 A 
                 4.440404368 
               
               
                 1KG 
                 16:74929641 
                 CNTNAP4 
                 0.8354 
                 0.0481 
                 0.0001849 
                 G 
                 3.738801021 
               
               
                 1KG 
                 11:1762440 
                 CTSD 
                 0.7781 
                 0.0567 
                 0.000009621 
                 T 
                 −4.425520544 
               
               
                 1KG 
                 9:114121319 
                 ROD1 
                 0.8504 
                 0.0454 
                 0.0003545 
                 A 
                 −3.571826678 
               
               
                   
               
             
          
           
               
                 REF 
                 hg_18_BP 
                 Gene (nearby) 
                 EA_OR 
                 ci− 
                 ci+ 
               
               
                   
               
               
                 1KG 
                 8:123521501 
                 ZHX2 
                 1.166725003 
                 0.794024723 
                 0.925185815 
               
               
                 1KG 
                 15:87314645 
                 MFGE8|ABHD2 
                 0.853096741 
                 1.082535879 
                 1.269290807 
               
               
                 1KG 
                 3:119674993 
                 IGSF11 
                 0.836470096 
                 1.092001781 
                 1.308807619 
               
               
                 1KG 
                 16:85846518 
                 LOC730018 
                 0.8754 
                 0.814163271 
                 0.941242607 
               
               
                 1KG 
                 8:128550166 
                 POU5F1B 
                 1.2349 
                 1.098105031 
                 1.38873602 
               
               
                 1KG 
                 10:88396729 
                 OPN4|RPL7AP8 
                 1.2022 
                 1.08230953 
                 1.335371074 
               
               
                 1KG 
                 4:182181154 
                 LINC00290 
                 1.2106 
                 1.082420898 
                 1.353957932 
               
               
                 1KG 
                 15:59828725 
                 VPS13C 
                 0.825 
                 0.730884457 
                 0.931234743 
               
               
                 1KG 
                 1:205515927 
                 CD55|C4BPAP2 
                 0.456183568 
                 1.624779296 
                 2.957510859 
               
               
                 1KG 
                 18:34125717 
                 CELF4 
                 1.188 
                 1.101004804 
                 1.281869066 
               
               
                 1KG 
                 16:74929641 
                 CNTNAP4 
                 1.197031362 
                 0.760240364 
                 0.917990142 
               
               
                 1KG 
                 11:1762440 
                 CTSD 
                 0.7781 
                 0.696259928 
                 0.869559751 
               
               
                 1KG 
                 9:114121319 
                 ROD1 
                 0.8504 
                 0.777997124 
                 0.929540917 
               
               
                   
               
             
          
         
       
     
         [0000]    
       
         
               
               
               
               
             
           
               
                 TABLE 9 
               
               
                   
               
               
                 GENE 
                 SNP 
                 CHR:BP 
                 GENE 
               
               
                   
               
             
             
               
                 HTRA1 
                 rs10490924 
                 10:124204438 
                 HTRA1 
               
               
                 CFH 
                 rs1061170 
                 1:194925860 
                 CFH 
               
               
                 CFH 
                 rs1410996 
                 11:194963556 
                 CFH 
               
               
                 CFB 
                 rs641153 
                 6:32022159 
                 CFB 
               
               
                 C3 
                 rs2230199 
                 19:6669387 
                 C3 
               
               
                 C2 
                 rs9332739 
                 6:32011783 
                 C2 
               
               
                 TIMP3 
                 rs9621532 
                 22:31414511 
                 TIMP3 
               
               
                 LIPC 
                 rs10468017 
                 15:56465804 
                 LIPC 
               
               
                 CFI 
                 rs10033900 
                 4:110878516 
                 CFI 
               
               
                 COL10A1, DSE, FRK, TSPY 
                 rs12204816 
                 6:116568331 
                 COL10A1, DSE, FRK, TSPY 
               
               
                 L1, TSPYL4 
                   
                   
                 L1, TSPYL4 
               
               
                 VEGFA 
                 rs4711751 
                 6:43936560 
                 VEGFA 
               
               
                 CETP 
                 rs3764261 
                 16:55550825 
                 CETP 
               
               
                 FRK 
                 rs1999930 
                 6:116493827 
                 FRK 
               
               
                 ABCA1 
                 rs1883025 
                 9:106704122 
                 ABCA1 
               
               
                 FRK/COL10A1 
                 rs12196141 
                 6:116596243 
                 FRK/COL10A1 
               
               
                 HCG27(0) 
                 rs9366769 
                 6:31277268 
                 HCG27(0) 
               
               
                 LIPC 
                 rs493258 
                 15:56475172 
                 LIPC 
               
               
                 COL8A1 
                 rs13095226 
                 3:100878962 
                 COL8A1 
               
               
                 TSHZ3(+107.3 kb) 
                 rs2052572 
                 19:36639376 
                 TSHZ3(+107.3 kb) 
               
               
                 NT5DC1(0) 
                 rs509859 
                 6:116529937 
                 NT5DC1(0) 
               
               
                 FILIP1L(0)|C3orf26(0) 
                 rs7626245 
                 3:101053451 
                 FILIP1L(0)|C3orf26(0) 
               
               
                 CNTNAP4 
                 rs8053796 
                 16:74921678 
                 CNTNAP4 
               
               
                 MYOM2(−1494 kb) 
                 rs722782 
                 8:506479 
                 MYOM2(−1494 kb) 
               
               
                 FAM135B(0) 
                 rs10103808 
                 8:139212254 
                 FAM135B(0) 
               
               
                 OTOL1(+488.4 kb) 
                 rs4256145 
                 3:163192835 
                 OTOL1(+488.4 kb) 
               
               
                 IRF4(−675.1 kb) 
                 rs9328048 
                 6:1324870 
                 IRF4(−675.1 kb) 
               
               
                 INTU 
                 rs1443179 
                 4:128495772 
                 INTU 
               
               
                 MEIS2(+20.97 kb) 
                 chr15:35201758 
                 15:35201758 
                 MEIS2(+20.97 kb) 
               
               
                 CTSD 
                 rs55911157 
                 11:1762440 
                 CTSD 
               
               
                 CDH12(−477.3 kb) 
                 rs2883171 
                 5:21309600 
                 CDH12(−477.3 kb) 
               
               
                 CNTNAP4 
                 rs6564324 
                 16:74929641 
                 CNTNAP4 
               
               
                 ZFAT(+315.9 kb)|KHDRBS 
                 rs13253938 
                 8:136110326 
                 ZFAT(+315.9 kb)|KHDRBS 
               
               
                 3(−428.6 kb) 
                   
                   
                 3(−428.6 kb) 
               
               
                 CDH9(−704.3 kb) 
                 chr5:26212150 
                 5:26212150 
                 CDH9(−704.3 kb) 
               
               
                 TNFRSF10A(+0.332 kb)|C 
                 rs13278062 
                 8:23138916 
                 TNFRSF10A(+0.332 kb)|C 
               
               
                 HMP7(−18.18 kb) 
                   
                   
                 HMP7(−18.18 kb) 
               
               
                 PCDH15(+149.1 kb) 
                 rs61856267 
                 10:56380194 
                 PCDH15(+149.1 kb) 
               
               
                 GDF6 
                 rs6982567 
                 8:96819457 
                 GDF6 
               
               
                 MRPL19(+489.6 kb) 
                 rs1851808 
                 2:76232489 
                 MRPL19(+489.6 kb) 
               
               
                 C1orf116, C4BPA, C4BPB, 
                 rs12040406 
                 1:205515927 
                 C1orf116, C4BPA, C4BPB, 
               
               
                 CD55, CR1, CR2, DAF, PFK 
                   
                   
                 CD55, CR1, CR2, DAF, PFK 
               
               
                 FB2, YOD1 
                   
                   
                 FB2, YOD1 
               
               
                 TKT 
                 rs12632671 
                 3:53233464 
                 TKT 
               
               
                 MOXD1(−134.9 
                 rs728371 
                 6:132523980 
                 MOXD1(−134.9 
               
               
                 kb)|CTGF(+209.8 kb) 
                   
                   
                 kb)|CTGF(+209.8 kb) 
               
               
                 GANC(0) 
                 rs12908430 
                 15:40375218 
                 GANC(0) 
               
               
                 MFGE8(+54.89 kb)|HAPLN 
                 rs11854658 
                 15:87312556 
                 MFGE8(+54.89 kb)|HAPLN 
               
               
                 3(+72.78 kb)|ACAN(+92.97 
                   
                   
                 3(+72.78 kb)|ACAN(+92.97 
               
               
                 kb)|ABHD2(−119.9 kb) 
                   
                   
                 kb)|ABHD2(−119.9 kb) 
               
               
                 TMCO1(0) 
                 chr1:163986967 
                 1:163986967 
                 TMCO1(0) 
               
               
                 SYNGAP1(0) 
                 rs9461856 
                 6:33503177 
                 SYNGAP1(0) 
               
               
                 USP31(+23 kb)|UBFD1(−385.3 
                 rs4967980 
                 16:23091095 
                 USP31(+23 kb)|UBFD1(−385.3 
               
               
                 kb)|SCNN1B(−130 
                   
                   
                 kb)|SCNN1B(−130 
               
               
                 kb)|SCNN1G(−10.45 
                   
                   
                 kb)|SCNN1G(−10.45 
               
               
                 kb)|COG7(−216.2 kb) 
                   
                   
                 kb)|COG7(−216.2 kb) 
               
               
                 RREB1 
                 rs11755724 
                 6:7063989 
                 RREB1 
               
               
                 WDR35(+148.1 kb)|TTC32(+236.3 
                 rs6531212 
                 2:20201501 
                 WDR35(+148.1 kb)|TTC32(+236.3 
               
               
                 kb)|SDC1(−62.54 
                   
                   
                 kb)|SDC1(−62.54 
               
               
                 kb)|PUM2(−110.4 
                   
                   
                 kb)|PUM2(−110.4 
               
               
                 kb)|MATN3(+125.6 
                   
                   
                 kb)|MATN3(+125.6 
               
               
                 kb)|LAPTM4A(+86.58 kb) 
                   
                   
                 kb)|LAPTM4A(+86.58 kb) 
               
               
                 PSMD7(−598.4 kb) 
                 rs2127740 
                 16:72289810 
                 PSMD7(−598.4 kb) 
               
               
                 TMCO5 
                 rs16965939 
                 15:35992085 
                 TMCO5 
               
               
                 MAPK10 
                 rs28621471 
                 4:86877248 
                 MAPK10 
               
               
                 TBX3(+404 kb) 
                 rs11067403 
                 12:114010367 
                 TBX3(+404 kb) 
               
               
                 B3GALTL(0) 
                 rs1912795 
                 13:30736688 
                 B3GALTL(0) 
               
               
                 GCNT4(+22.83 kb)|HMGC 
                 rs12520598 
                 5:74385314 
                 GCNT4(+22.83 kb)|HMGC 
               
               
                 R(−283.5 kb) 
                   
                   
                 R(−283.5 kb) 
               
               
                 IGSF11(−421 kb) 
                 rs1915098 
                 3:119681130 
                 IGSF11(−421 kb) 
               
               
                 ADAMTS16 
                 rs7720497 
                 5:5291813 
                 ADAMTS16 
               
               
                 LSAMP(+563.4 kb) 
                 rs1540819 
                 3:118210505 
                 LSAMP(+563.4 kb) 
               
               
                 CNTNAP5(0) 
                 rs9308649 
                 2:124751486 
                 CNTNAP5(0) 
               
               
                 NEDD4L(0) 
                 rs529478 
                 18:53934507 
                 NEDD4L(0) 
               
               
                 CREG1 
                 rs1737478 
                 1:165795961 
                 CREG1 
               
               
                   
                 rs12637095 
                 3:119674993 
               
               
                 BRUNOL4(+711.5 kb) 
                 rs8091635 
                 18:34111545 
                 BRUNOL4(+711.5 kb) 
               
               
                 FOXP1(0) 
                 rs2135548 
                 3:71584585 
                 FOXP1(0) 
               
               
                 SDC3(−13.09 kb)|PUM1(−75.13 
                 rs2491146 
                 1:31101812 
                 SDC3(−13.09 kb)|PUM1(−75.13 
               
               
                 kb)|MATN1(+132.3 
                   
                   
                 kb)|MATN1(+132.3 
               
               
                 kb)|LAPTM5(+98.56 kb) 
                   
                   
                 kb)|LAPTM5(+98.56 kb) 
               
               
                 GRM3(−34.61 kb) 
                 rs1358395 
                 7:86076557 
                 GRM3(−34.61 kb) 
               
               
                 ACVR1B, ACVRL1, bpl_41- 
                 rs7958529 
                 12:50881293 
                 ACVR1B, ACVRL1, bpl_41- 
               
               
                 16, C12orf44, GRASP, KRT 
                   
                   
                 16, C12orf44, GRASP, KRT 
               
               
                 6A, KRT6B, KRT6C, KRT7, 
                   
                   
                 6A, KRT6B, KRT6C, KRT7, 
               
               
                 KRT75, KRT80, KRT81, KR 
                   
                   
                 KRT75, KRT80, KRT81, KR 
               
               
                 T82, KRT83, KRT84, KRT85, 
                   
                   
                 T82, KRT83, KRT84, KRT85, 
               
               
                 KRT86, NR4A1 
                   
                   
                 KRT86, NR4A1 
               
               
                 EPHA7(−434.6 kb) 
                 rs2037156 
                 6:93573222 
                 EPHA7(−434.6 kb) 
               
               
                 HMGCLL1(0) 
                 rs4260755 
                 6:55456674 
                 HMGCLL1(0) 
               
               
                 OSBPL11(0) 
                 chr3:126793536 
                 3:126793536 
                 OSBPL11(0) 
               
               
                 SPHAR(−384.2 
                 rs6685751 
                 1:227122574 
                 SPHAR(−384.2 
               
               
                 kb)|RHOU(+173.5 kb) 
                   
                   
                 kb)|RHOU(+173.5 kb) 
               
               
                 |RAB4A(−350.9 kb) 
                   
                   
                 |RAB4A(−350.9 kb) 
               
               
                 PARK2(0) 
                 chr6:162467903 
                 6:162467903 
                 PARK2(0) 
               
               
                 TAF3(+129.4 kb)|KIN(+356.1 
                 rs2798832 
                 10:8226099 
                 TAF3(+129.4 kb)|KIN(+356.1 
               
               
                 kb)|ITIH2(+394.6 kb)|ITIH 
                   
                   
                 kb)|ITIH2(+394.6 kb)|ITIH 
               
               
                 5(+477.2 kb)|GATA3(+68.93 
                   
                   
                 5(+477.2 kb)|GATA3(+68.93 
               
               
                 kb)|FLJ45983(+90.65 kb)| 
                   
                   
                 kb)|FLJ45983(+90.65 kb)| 
               
               
                 ATP5C1(+336.3 kb) 
                   
                   
                 ATP5C1(+336.3 kb) 
               
               
                 PPM1B(−116.7 kb)|LRPPRC(+56.13 
                 chr2:44132778 
                 2:44132778 
                 PPM1B(−116.7 kb)|LRPPRC(+56.13 
               
               
                 kb) 
                   
                   
                 kb) 
               
               
                 C4BPAL1, C4BPA, CD55 
                 rs1367068 
                 1:205461564 
                 C4BPAL1, C4BPA, CD55 
               
               
                 TMEM133(−218.2 kb)|PGR(255.8 
                 rs625761 
                 11:100149779 
                 TMEM133(−218.2 kb)|PGR(255.8 
               
               
                 kb)∥CNTN5(+417.1 kb) 
                   
                   
                 kb)∥CNTN5(+417.1 kb) 
               
               
                 IGF2R(0) 
                 rs1867348 
                 6:160376153 
                 IGF2R(0) 
               
               
                 P4HA3(0) 
                 rs513683 
                 11:73662041 
                 P4HA3(0) 
               
               
                 DGKB 
                 rs7783337 
                 7:14123511 
                 DGKB 
               
               
                 VSTM2A(+132.5 kb)|SEC6 
                 rs10225927 
                 7:54736904 
                 VSTM2A(+132.5 kb)|SEC6 
               
               
                 1G(−50.53 kb)|EGFR(−317.3 kb) 
                   
                   
                 1G(−50.53 kb)|EGFR(−317.3 kb) 
               
               
                 RAP2B(+65.39 kb) 
                 rs16822447 
                 3:154434339 
                 RAP2B(+65.39 kb) 
               
               
                 TCOF1(0) 
                 chr5:149749881 
                 5:149749881 
                 TCOF1(0) 
               
               
                 SGCZ(−276.3 
                 rs1384044 
                 8:13715406 
                 SGCZ(−276.3 
               
               
                 kb)|DLC1(+298.6 kb) 
                   
                   
                 kb)|DLC1(+298.6 kb) 
               
               
                 RPP30(−238.9 kb)|HTR7(−107.8 
                 rs7094579 
                 10:92382787 
                 RPP30(−238.9 kb)|HTR7(−107.8 
               
               
                 kb)|ANKRD1(−279 kb) 
                   
                   
                 kb)|ANKRD1(−279 kb) 
               
               
                 CELF4 
                 rs17628762 
                 18:34125717 
                 CELF4 
               
               
                 TCL1B 
                 rs8011890 
                 14:95216646 
                 TCL1B 
               
               
                   
                 rs3748391 
                 16:85846518 
               
               
                 RELL1(−428.5 kb)|C4orf19(−291.6 kb) 
                 rs2376241 
                 4:36840346 
                 RELL1(−428.5 kb)|C4orf19(−291.6 kb) 
               
               
                   
                 rs4282579 
                 8:123521501 
               
               
                 CTSD(−231.9 kb) 
                 chr11:1768072 
                 11:1768072 
                 CTSD(−231.9 kb) 
               
               
                 WAPAL(+72.97 kb)|OPN4(−59.8 kb) 
                 chr10:88344492 
                 10:88344492 
                 WAPAL(+72.97 kb)|OPN4(−59.8 kb) 
               
               
                 CACNA1C(0) 
                 rs10848645 
                 12:2290505 
                 CACNA1C(0) 
               
               
                 MME(−18.73 kb) 
                 rs13094238 
                 3:156261403 
                 MME(−18.73 kb) 
               
               
                 KIAA1604(+216.2 kb) 
                 chr2:180796214 
                 2:180796214 
                 KIAA1604(+216.2 kb) 
               
               
                 ANKRD54, CARD10, CAR 
                 rs1079982 
                 22:36259705 
                 ANKRD54, CARD10, CAR 
               
               
                 MA3, CDC42EP1, FLJ0001 
                   
                   
                 MA3, CDC42EP1, FLJ0001 
               
               
                 7, GALR3, GCAT, GGA1, H1 
                   
                   
                 7, GALR3, GCAT, GGA1, H1 
               
               
                 F0, LGALS1, LGALS2, LRR 
                   
                   
                 F0, LGALS1, LGALS2, LRR 
               
               
                 C62, MFNG, NOL12, PDXP, 
                   
                   
                 C62, MFNG, NOL12, PDXP, 
               
               
                 PSCD4, RAC2, SH3BP1, T 
                   
                   
                 PSCD4, RAC2, SH3BP1, T 
               
               
                 RIOBP 
                   
                   
                 RIOBP 
               
               
                 FLJ37543(+74.42 kb) 
                 rs9291737 
                 5:61112540 
                 FLJ37543(+74.42 kb) 
               
               
                 EFNA5(0) 
                 rs164700 
                 5:106936632 
                 EFNA5(0) 
               
               
                 FUT3 
                 rs3760775 
                 19:5792356 
                 FUT3 
               
               
                   
                 rs11856826 
                 15:87314645 
               
               
                 SLC18A1 
                 rs2270637 
                 8:20081107 
                 SLC18A1 
               
               
                 PPARGC1A(−214.7 kb) 
                 chr4:23188024 
                 4:23188024 
                 PPARGC1A(−214.7 kb) 
               
               
                 RAG2(+1021 kb) 
                 rs10768315 
                 11:37597461 
                 RAG2(+1021 kb) 
               
               
                 CDGAP(0) 
                 rs9713311 
                 3:120558458 
                 CDGAP(0) 
               
               
                 MBP 
                 rs1789110 
                 18:72988032 
                 MBP 
               
               
                 SPATA20 
                 rs8076470 
                 17:45980827 
                 SPATA20 
               
               
                 ARHGAP12(−98.91 kb) 
                 rs2277252 
                 10:32036318 
                 ARHGAP12(−98.91 kb) 
               
               
                 KCNN2(−80.47 kb) 
                 chr5:113645446 
                 5:113645446 
                 KCNN2(−80.47 kb) 
               
               
                 NDUFS4(−271 
                 rs251525 
                 5:52621268 
                 NDUFS4(−271 
               
               
                 kb)|MOCS2(+179.9 kb)| 
                   
                   
                 kb)|MOCS2(+179.9 kb)| 
               
               
                 ITGA2(+194.9 kb)|ITGA1(+336 
                   
                   
                 ITGA2(+194.9 kb)|ITGA1(+ 336 
               
               
                 kb)|FST(−191.1 kb) 
                   
                   
                 kb)|FST(−191.1 kb) 
               
               
                 ITGA9(0) 
                 rs11716363 
                 3:37504640 
                 ITGA9(0) 
               
               
                 AGL(+4.508 kb)|SLC35A3(−41.45 kb) 
                 chr1:100166675 
                 1:100166675 
                 AGL(+4.508 kb)|SLC35A3(−41.45 kb) 
               
               
                 NDFIP2(0) 
                 rs17071512 
                 13:78960018 
                 NDFIP2(0) 
               
               
                 PDGFD(0) 
                 rs12798294 
                 11:103362906 
                 PDGFD(0) 
               
               
                 ZWINT(−308.1 kb) 
                 chr10:57479107 
                 10:57479107 
                 ZWINT(−308.1 kb) 
               
               
                 FOXF1(−172.4 kb) 
                 rs12926103 
                 16:84929276 
                 FOXF1(−172.4 kb) 
               
               
                 RREB1(0) 
                 rs1360751 
                 6:7152544 
                 RREB1(0) 
               
               
                 ROD1(0) 
                 rs10739343 
                 9:114121319 
                 ROD1(0) 
               
               
                 TRA2A, IGF2BP3, CLK2P 
                 rs10280782 
                 7:23550807 
                 TRA2A, IGF2BP3, CLK2P 
               
               
                   
                 rs11854497 
                 15:59828725 
               
               
                 TUBB1(−48.54 kb)|TH1L(−10.54 
                   
                 20:56979160 
                 TUBB1(−48.54 kb)|TH1L(−10.54 
               
               
                 kb)|STX16(+291.2 kb) 
                 rs235195 
                   
                 kb)|STX16(+291.2 kb) 
               
               
                 |SLMO2(−62.43 kb)|NPEPL1(+254.9 
                   
                   
                 |SLMO2(−62.43 kb)|NPEPL1(+254.9 
               
               
                 kb)|GNAS(+59.52 kb)|CTSZ 
                   
                   
                 kb)|GNAS(+59.52 kb)|CTSZ 
               
               
                 (−24.47 kb)|ATP5E(−57.97 kb) 
                   
                   
                 (−24.47 kb)|ATP5E(−57.97 kb) 
               
               
                 AEBP2(+312 kb) 
                 rs1492116 
                 12:19878442 
                 AEBP2(+312 kb) 
               
               
                 KLF6(+127.8 kb) 
                 rs11592003 
                 10:3945290 
                 KLF6(+127.8 kb) 
               
               
                 SDCCAG10(0) 
                 rs10067691 
                 5:64292165 
                 SDCCAG10(0) 
               
               
                 ODZ2(−1511 kb) 
                 chr5:165133520 
                 5:165133520 
                 ODZ2(−1511 kb) 
               
               
                 NUTF2(0) 
                 rs2271293 
                 16:66459571 
                 NUTF2(0) 
               
               
                 HNF4A(0) 
                 rs1800961 
                 20:42475778 
                 HNF4A(0) 
               
               
                 CASP4(−133.1 kb) 
                 chr11:104185708 
                 11:104185708 
                 CASP4(−133.1 kb) 
               
               
                 ZNF692(+10.26 kb)|SH3B 
                 rs6587759 
                 1:247130153 
                 ZNF692(+10.26 kb)|SH3B 
               
               
                 P5L(+43.38 kb)|PGBD2(−36.91 kb)| 
                   
                   
                 P5L(+43.38 kb)|PGBD2(−36.91 kb)| 
               
               
                 MRPS24 
                 rs2730613 
                 7:43880667 
                 MRPS24 
               
               
                 SGCZ(0) 
                 rs10503493 
                 8:14247492 
                 SGCZ(0) 
               
               
                 PCIF1(0) 
                 rs7679 
                 20:44009909 
                 PCIF1(0) 
               
               
                 XYLT1(0) 
                 chr16:17310751 
                 16:17310751 
                 XYLT1(0) 
               
               
                 TBX20(+335.4 kb)|SEPT7(−212 
                 rs343718 
                 7:35595154 
                 TBX20(+335.4 kb)|SEPT7(−212 
               
               
                 kb)|HERPUD2(−43.64 kb) 
                   
                   
                 kb)|HERPUD2(−43.64 kb) 
               
               
                 FSTL5(0) 
                 rs17639345 
                 4:162971300 
                 FSTL5(0) 
               
               
                 SLC1A1 
                 rs10815017 
                 9:4536594 
                 SLC1A1 
               
               
                   
                 rs2803544 
                 10:88396729 
               
               
                   
                 rs9997006 
                 4:182181154 
               
               
                   
                 rs10233234 
                 7:23498756 
               
               
                 DAB1(−16.87 
                 rs1418473 
                 1:57219300 
                 DAB1(−16.87 
               
               
                 kb)|C8B(+15.02 kb)|C 
                   
                   
                 kb)|C8B(+15.02 kb)|C 
               
               
                 8A(+62.82 kb) 
                   
                   
                 8A(+62.82 kb) 
               
               
                 FAM113B 
                 rs11183802 
                 12:45893566 
                 FAM113B 
               
               
                   
                 rs10089310 
                 8:128550166 
               
               
                 ZC3H7A(+30.67 kb)|TXND 
                 rs2024393 
                 16:11814579 
                 ZC3H7A(+30.67 kb)|TXND 
               
               
                 C11(+70.43 kb)|TNFRSF1 
                   
                   
                 C11(+70.43 kb)|TNFRSF1 
               
               
                 7(−151.9 
                   
                   
                 7(−151.9 
               
               
                 kb)|SNN(+134.1 kb)| 
                   
                   
                 kb)|SNN(+134.1 kb)| 
               
               
                 RUNDC2A(−163.5 
                   
                   
                 RUNDC2A(−163.5 
               
               
                 kb)|RSL1D1(−20.98 
                   
                   
                 kb)|RSL1D1(−20.98 
               
               
                 kb)|GSPT1(−54.91 kb) 
                   
                   
                 kb)|GSPT1(−54.91 kb) 
               
               
                 LILRB3 
                 rs7260457 
                 19:59425996 
                 LILRB3 
               
               
                 PLN(+129.5 kb)|MCM9(−155.7 
                 chr6:119117772 
                 6:119117772 
                 PLN(+129.5 kb)|MCM9(−155.7 
               
               
                 kb)|ASF1A(−145.9 kb) 
                   
                   
                 kb)|ASF1A(−145.9 kb) 
               
               
                   
                 rs7973431 
                 12:92165329 
               
               
                 ELTD1(+115.3 kb) 
                 rs17408651 
                 1:79360392 
                 ELTD1(+115.3 kb) 
               
               
                 DDAH1(+53.95 kb)|CYR61 
                 chr1:85757359 
                 1:85757359 
                 DDAH1(+53.95 kb)|CYR61 
               
               
                 (−61.69 kb) 
                   
                   
                 (−61.69 kb) 
               
               
                 upstream AK125078 
                 rs1326005 
                 1:5303445 
                 upstream AK125078 
               
               
                   
                 rs11736266 
                 4:165142286 
               
               
                 A2ML1(0) 
                 chr12:8919954 
                 12:8919954 
                 A2ML1(0) 
               
               
                 FADS1(0) 
                 rs174547 
                 11:61327359 
                 FADS1(0) 
               
               
                   
                 rs4939883 
                 18:45421212 
               
               
                 ARL5B(+385.1 kb) 
                 rs11596472 
                 10:19392088 
                 ARL5B(+385.1 kb) 
               
               
                   
                 rs964184 
                 11:116154127 
               
               
                 ATP8B4(0) 
                 chr15:47957127 
                 15:47957127 
                 ATP8B4(0) 
               
               
                 downstream AK058053 
                 rs4771513 
                 13:105365389 
                 downstream AK058053 
               
               
                   
                 rs7317763 
                 13:83069357 
               
               
                 OR7C1(+3.191 kb)|OR7A5 
                 chr19:14775139 
                 19:14775139 
                 OR7C1(+3.191 kb)|OR7A5 
               
               
                 (−23 kb) 
                   
                   
                 (−23 kb) 
               
               
                 upstream QSER1 
                 rs4755455 
                 11:32859894 
                 upstream QSER1 
               
               
                   
                 rs7973032 
                 12:80847264 
               
               
                 MGAT5B(+25.65 kb) 
                 chr17:72483712 
                 17:72483712 
                 MGAT5B(+25.65 kb) 
               
               
                 COL5A2(alpha 2 type V 
                 rs10207860 
                 2:189854831 
                 COL5A2(alpha 2 type V 
               
               
                 collagen preprotein) 
                   
                   
                 collagen preprotein) 
               
               
                 SCARB1 
                 rs5888 
                 12:123850701 
                 SCARB1 
               
               
                 BC034940 
                 rs2032794 
                 5:86468373 
                 BC034940 
               
               
                 NETO1 
                 rs11876415 
                 18:68641554 
                 NETO1 
               
               
                 GREM1(0) 
                 rs3743105 
                 15:30811243 
                 GREM1(0) 
               
               
                   
                 rs2469875 
                 18:36481096 
               
               
                 ODZ3(−1293 kb) 
                 chr4:182189551 
                 4:182189551 
                 ODZ3(−1293 kb) 
               
               
                 ZBTB20(+12.48 kb) 
                 chr3:116361297 
                 3:116361297 
                 ZBTB20(+12.48 kb) 
               
               
                 SESN1(0) 
                 rs13192030 
                 6:109470664 
                 SESN1(0) 
               
               
                 ZHX2(−341.2 kb) 
                 chr8:123521912 
                 8:123521912 
                 ZHX2(−341.2 kb) 
               
               
                 GALNT2(0) 
                 rs4846914 
                 1:228362314 
                 GALNT2(0) 
               
               
                 PRR5(−270.7 
                 rs135912 
                 22:43172593 
                 PRR5(−270.7 
               
               
                 kb)|PARVB(+276.2 
                   
                   
                 kb)|PARVB(+276.2 
               
               
                 kb)|PARVG(+238.7 kb)|LDO 
                   
                   
                 kb)|PARVG(+238.7 kb)|LDO 
               
               
                 C1L(−94.52 
                   
                   
                 C1L(−94.52 
               
               
                 kb)|KIAA1644(+132.5 kb) 
                   
                   
                 kb)|KIAA1644(+132.5 kb) 
               
               
                 FGGY(−58.3 kb) 
                 chr1:59476907 
                 1:59476907 
                 FGGY(−58.3 kb) 
               
               
                 USH2A(+36.74 kb)|TGFB2 
                 rs6679773 
                 1:214700097 
                 USH2A(+36.74 kb)|TGFB2 
               
               
                 (−1886 kb)|SPATA17(−1171 
                   
                   
                 (−1886 kb)|SPATA17(−1171 
               
               
                 kb)|RRP15(−1825 kb)|PTPN14(+1909 
                   
                   
                 kb)|RRP15(−1825 kb)|PTPN14(+1909 
               
               
                 kb)|KCTD3(+838.3 kb)|KCNK 
                   
                   
                 kb)|KCTD3(+838.3 kb)|KCNK 
               
               
                 2(+1223 kb)|GPATCH2(−970.4 
                   
                   
                 2(+1223 kb)|GPATCH2(−970.4 
               
               
                 kb)|ESRRG(−43.11 
                   
                   
                 kb)|ESRRG(−43.11 
               
               
                 kb)|CENPF(+1796 kb) 
                   
                   
                 kb)|CENPF(+1796 kb) 
               
               
                   
                 rs958646 
                 20:4486243 
               
               
                 FAM19A5 
                 rs5771717 
                 22:47467676 
                 FAM19A5 
               
               
                 TNRC6C(+225.5 kb)|TMC8 
                 rs16971055 
                 17:73838135 
                 TNRC6C(+225.5 kb)|TMC8 
               
               
                 (+187.5 kb)|TMC6(+198.1 
                   
                   
                 (+187.5 kb)|TMC6(+198.1 
               
               
                 kb)|TK1(+143.3 kb)|SYNGR 
                   
                   
                 kb)|TK1(+143.3 kb)|SYNGR 
               
               
                 2(+157.5 kb)|SOCS3(−26.32 
                   
                   
                 2(+157.5 kb)|SOCS3(−26.32 
               
               
                 kb)|PGS1(−48.19 
                   
                   
                 kb)|PGS1(−48.19 
               
               
                 kb)|BIRC5(+104.8 kb) 
                   
                   
                 kb)|BIRC5(+104.8 kb) 
               
               
                 |AFMID(+122.8 kb) 
                   
                   
                 |AFMID(+122.8 kb) 
               
               
                   
                 rs16924889 
                 10:24883792 
               
               
                 WDFY3(+99.94 kb) 
                 chr4:86206508 
                 4:86206508 
                 WDFY3(+99.94 kb) 
               
               
                 NPLOC4(0) 
                 rs4073997 
                 17:77136846 
                 NPLOC4(0) 
               
               
                 ISX(+77.68 kb)|HMG2L1(−92.42 
                 chr22:33891064 
                 22:33891064 
                 ISX(+77.68 kb)|HMG2L1(−92.42 
               
               
                 kb) 
                   
                   
                 kb) 
               
               
                 KCTD10(0) 
                 rs2338104 
                 12:108379551 
                 KCTD10(0) 
               
               
                 RHO(−139 kb)|MBD4(−41.36 
                 rs12632105 
                 3:130591125 
                 RHO(−139 kb)|MBD4(−41.36 
               
               
                 kb)|IFT122(−50.53 
                   
                   
                 kb)|IFT122(−50.53 
               
               
                 kb)|H1FX(+73.32 kb)| 
                   
                   
                 kb)|H1FX(+73.32 kb)| 
               
               
                 COPG(+111.8 kb) 
                   
                   
                 COPG(+111.8 kb) 
               
               
                 DAB1(0) 
                 rs11207037 
                 1:57677552 
                 DAB1(0) 
               
               
                   
                 rs12678919 
                 8:19888502 
               
               
                 DKFZp667G2110(0) 
                 rs7623235 
                 3:99135842 
                 DKFZp667G2110(0) 
               
               
                 HIBADH(−56.23 kb) 
                 rs17155281 
                 7:27475356 
                 HIBADH(−56.23 kb) 
               
               
                   
                 rs9475939 
                 6:57396889 
               
               
                 ROBO3(−27.68 kb)|C11orf61(+37.3 
                 chr11:124212812 
                 11:124212812 
                 ROBO3(−27.68 kb)|C11orf61(+37.3 
               
               
                 kb) 
                   
                   
                 kb) 
               
               
                   
                 rs2967605 
                 19:8375738 
               
               
                 INDO(+194.4 kb) 
                 chr8:40099493 
                 8:40099493 
                 INDO(+194.4 kb) 
               
               
                 TAS2R42(+2.424 kb) 
                 chr12:11233234 
                 12:11233234 
                 TAS2R42(+2.424 kb) 
               
               
                 ENPP3(0) 
                 rs5015852 
                 6:132002096 
                 ENPP3(0) 
               
               
                   
                 rs2453727 
                 1:185513773 
               
               
                 TTC39B(0) 
                 rs471364 
                 9:15279578 
                 TTC39B(0) 
               
               
                 DYSF(0) 
                 rs13402171 
                 2:71597893 
                 DYSF(0)