Abstract:
The invention relates to a housing ( 1 ) that is especially designed to be associated with a device for a tight connection to a second housing ( 2 ), said first housing comprising a structure including a wall ( 3 ) defining a space ( 1   a ), an opening ( 4 ) defined by a flange ( 5 ) that can be hermetically applied to a second flange ( 9 ) of the second housing ( 2 ), holding means that can keep the first flange and the second flange ( 9 ) applied to each other, a door ( 6 ) supported by carrying means ( 11   a ), the door leaf ( 6   v ) being mobile in such a way as to be closed or open and having an outer face ( 6   a ) that can ensure the hermetic application of a second door ( 10 ) of the second housing ( 2 ), fixing means for holding the leaves ( 6   v   , 1  Ov) against each other, displacement manoeuvring means ( 11   b ), and means for controlling the displacement manoeuvring means ( 11   b ), and, when the leaf ( 6   v ) is open, an inlet/outlet space ( 13   a ) in/of the inner space ( 1   a ) forming part of a communication space ( 13 ) between the two housings ( 1, 2 ), wherein the carrying means ( 11   a ) and the displacement manoeuvring means ( 11   b ) for the door ( 6 ) are arranged in such a way that, when the leaf ( 6   v ) is open, it extends essentially past the limit ( 13   b   , 13   c ) of the inlet/outlet space ( 13   a ), a distancing space ( 12 ) being thus created between the inlet/outlet space ( 13   a ) and the leaf ( 6   v ) in the open state.

Description:
FIELD OF THE INVENTION 
     The invention relates to a chamber designed to be part, with a second chamber, of a sealed junction device and of an aseptic transfer device. 
     BACKGROUND OF THE INVENTION 
     Aseptic transfer devices of the double-door type are already known. Purely by way of example, the devices known under the trademark BIOSAFE® and the sealed junction devices between a first chamber and a second chamber isolated from an external environment that are described in the document EP-A-0688020 can be cited. 
     The object of the invention is said first chamber of devices of this type. In the text as a whole, this chamber is most often called “chamber” or sometimes “first chamber” particularly to distinguish it from the other chamber of the junction device and of the transfer device, this other chamber being called “second chamber.” It is understood that the term “chamber” without any other details and the expression “first chamber” are synonyms and indicate the same object. 
     A first known chamber such as the one used in the biopharmaceutical field is typically stationary, rigid, and of relatively large size, and it comprises:
         A structure that includes a closed wall that borders an inside space,   At least one opening—the diameter of which can typically be on the order of 10 to 40 centimeters—made in the wall and bordered by an annular flange whose outside surface is able to ensure the hermetically-sealed flattening onto itself of the outside surface of a second complementary flange that is part of the second chamber,   Removable holding means, at least partly combined with the flange, able to hold—in a removable way—the flange and the second flange that are flattened against one another by their outside surfaces,   A door supported by the structure by means of carrying means, of a mechanical, movable, or deformable nature, the panel of which is arranged and mounted so as to be able to be moved to be either in the closed state where it works with the flange while closing the opening or in the open state where it is separated from the flange and placed in the inside space while opening the opening, and whose outside surface is able to ensure the hermetically-sealed flattening onto itself of the outside surface of the panel of a second complementary door that is part of the second chamber,   Removable interlocking means at least partly combined with the door, able to hold—in a removable way—the panel and the second panel that are flattened against one another by their outside surfaces,   Movement actuation means able to move the panel, with which the second panel is interlocked, between its closed and open states, and means for monitoring the movement actuation means,   And, when the panel is in the open state, an entrance/exit space in/of the inside space, in the general shape of a truncated cylinder, cone, or pyramid, that extends into the inside space at least approximately axially from the opening and from the flange, able to make it possible to pass certain contents into/out of the inside space from one to the other of the two chambers.       

     The second chamber is typically a movable container, disposable, at least partly flexible and of a smaller size, and it comprises the second wall equipped with the second opening bordered by the second annular flange that forms, on the one hand, an interface with the first flange, and, on the other hand, a seat for the second door whose panel is mounted for movement and arranged to be in the closed state or in the open state where, respectively, it closes or opens the second opening. 
     In the case of the embodiment known under the BIOSAFE® trademark, the carrying means and the movement actuation means of the first door and of its panel comprise a hinge whose axis—vertical and lateral—is located in the first chamber itself (the inside space of this first chamber), in or near the inside surface of its wall, near its opening and its flange, the pivoting around the hinge being performed manually or in a motorized way (actuator, motor . . . ). In the closed state, the panel is retracted in or in the vicinity of the plane of the wall, of the opening and of the flange. In the open state, the panel is projecting, in particular placed more or less perpendicularly to the plane of the wall, of the opening, and of the flange. The movement of the panel between its closed state and its open state (and vice versa) is on the order of one-third of a rotation. As for the movement actuation means, such as an actuator, motor . . . , they are able to move the panel to rotate on this course. 
     In the embodiments described in the document EP-A-2091051, where the axis is also vertical and lateral, in the documents EP-A-1 141 974, EP-A-1 454 328, EP-A-0 730 907, EP-A-0 830 896 where the axis is inferior horizontal (below the opening and the flange) and in the document EP-A-0 662 373, where the axis is superior horizontal, in the open state, the panel is also projecting and more or less perpendicular to the plane of the wall, the opening and the flange. 
     When the two chambers are in communication with one another through their respective openings in the open state, the entrance/exit space is part of a communication space between the two chambers that makes it possible to pass certain contents from one to the other of the two chambers and, thus, to transfer them from one chamber to the other. 
     In these embodiments, in the open state of the panel, the panel is laterally adjacent to the lateral boundary of the entrance/exit space, which can pose the problem that the panel is an impediment to the use of the sealed junction device and of the aseptic transfer device because a panel obstructs the passage of the certain contents from one of the two chambers to the other and, also, because the certain contents can reach the panel during their passage into the entrance/exit space, with risks of deterioration or contamination. 
     Transfers, such as those in question, can be necessary in a number of technical fields, particularly but not exclusively the biopharmaceutical field. The invention focuses especially on this field, as on those that can be considered as similar with regard to the requirements imposed. 
     Transfers, such as those considered here, occur most often in the framework of more complex processes in which the certain contents undergo one or more operations before and/or after the transfer. These operations consist in manufacturing, assembly, treatment, handling, use, measurement, monitoring, analysis, or the like . . . . 
     In the case of an operating line, a chamber can be provided that comprises a wall equipped with the same plurality of openings and doors, as well as sealed junction devices with a multiplicity of second chambers. 
     As document EP-A-1141672 states, one skilled in the art knows that with the type of aseptic transfer device under consideration, there exists what is called a “critical line” having residual contamination by the environment external to the two chambers. It is possible that this line comes into contact with the external environment that is found in the passage between the two chambers or into contact with the contents passing through this passage to be transferred from one chamber to the other, with, as a consequence, contamination. This critical line is sometimes called “critical zone” or “ring of concern” (see PIC/S—Pharmaceutical Inspection Convention— RECOMMENDATION—ISOLATORS USED FOR ASEPTIC PROCESSING AND STERILITY TESTING ). 
     An inside critical line is found on the outside surface of the first door, more precisely of its panel, in contact with the external environment and not overlapped by the outside surface of the second door, more precisely of its panel, when the two panels are flattened against one another. An outside critical line is found on the outside surface of the second flange in contact with the external environment and not overlapped by the outside surface of the first flange, when the two flanges are flattened against one another. 
     Embodiments such as those described in the documents EP-A-1 141 974, EP-A-1 454 328, EP-A-0 730 907, EP-A-0 830 896, EP-A-0 662 373 and EP-A-2091051 have as a drawback that in its open state, the panel is close to the opening of the chamber and of the entrance/exit space, so that the certain contents can reach the panel during their passage into the entrance/exit space, with the inherent risks of deterioration, contamination . . . . 
     Several solutions have been proposed for the purpose of overcoming the risk of contamination in the critical lines, a risk that is also mentioned in  ISOLATION TECHNOLOGY—A PRACTICAL GUIDE , published by CRC Press in 2004. 
     The document EP-A-0960698 provides decontamination means using ultraviolet, pulsed-ultraviolet, or pulsed-light radiation. The document EP-A-0662373 provides that a flanged ring of the aseptic transfer device comprises a heat-resistant annular element. Variants of heating technology are described in the documents EP-A-730907 and EP-A-830907. The technology of sterilization by dry heat has been indicated as being the preferred solution according to the presentation made by the Barrier Users Group Symposium (BUGS) at the conference of Jan. 17 and 18, 1995. The document EP-A-1454328 describes an aseptic transfer device that comprises a device for protection of the single outside critical line. 
     The state of the art also comprises the documents U.S. Pat. No. 3,489,298, EP 0586307, EP 0 830896, WO 03/041087, WO 95/34078, FR2833745, FR 2787 235, US 2009/212054 and WO 96/21615. However, none of these documents provides for the chamber being such that:
         On the one hand, the carrying means and the movement actuation means are arranged so that in the open state of the panel, the panel is substantially separated beyond the boundary of the entrance/exit space, and so that thus an empty separation space is made between the entrance/exit space and the panel in the open state, beyond the lateral boundary and the distal end boundary of the entrance/exit space opposite the opening and the flange;   And, on the other hand, the carrying means and the movement actuation means, structurally integrated into the door, constitute means for protection against the risks of contamination for the inside critical line, constituted by the separation space of appropriate size formed and placed between the entrance/exit space and the inside critical annular line, so that the certain contents normally cannot reach the panel during their passage into the entrance/exit space.       

     The problem at the base of the invention is to equip a (first) chamber designed to be part of a sealed junction device and of an aseptic transfer device with a second chamber of a structure such that the (first) panel of the (first) door of the (first) chamber in the open state is not an impediment to the use of the sealed junction device and of the aseptic transfer device, particularly does not obstruct the passage of the certain contents from one to the other of the two chambers, especially the passage of the certain contents into the entrance/exit space of the first chamber, and also that the certain contents cannot reach the first panel during their passage into the entrance/exit space, with the advantage of overcoming the risks of deterioration or contamination when that is not the case. In other words, the invention aims at seeing to it that the entrance/exit space and the communication space are separated, which is particularly useful, for example, for the passage of certain powdered contents when a transfer cone is used. 
     Another aspect of the problem on which the invention is based is to produce a chamber whose opening has a diameter that is larger than the currently typical openings—on the order of 10 to 40 centimeters. Such a wider opening increases the obstruction problem previously mentioned. 
     SUMMARY OF THE INVENTION 
     To that end, and according to a first aspect, the invention has as its object a chamber specially designed to be combined, in a sealed junction device, with a second chamber of the type comprising:
         A structure that includes a closed wall that borders an inside space,   At least one opening made in the wall and bordered by an annular flange whose outside surface is able to ensure the hermetically-sealed flattening onto itself of the outside surface of a second complementary flange that is part of the second chamber,   Movable holding means, at least partly combined with the flange, able to hold—in a removable way—the flange and the second flange that are flattened against one another by their outside surfaces,   A door supported by the structure by means of movable or deformable carrying means, the panel of which is arranged and mounted so as to be able to be moved to be either in the closed state where it works with the flange on closing the opening or in the open state where it is separated from the flange and placed in the inside space on opening the opening, and whose outside surface is able to ensure the hermetically-sealed flattening onto itself of the outside surface of the panel of a second complementary door that is part of the second chamber,   Movable interlocking means at least partly combined with the door, able to hold—in a removable way—the panel and the second panel that are flattened against one another by their outside surfaces,   Movement actuation means able to move the panel between its closed and open states, and means for monitoring the movement actuation means,   And, when the panel is in the open state, the entrance/exit of the chamber being separated, an entrance/exit space in/of the inside space, in the general shape of a truncated cylinder, cone, or pyramid, that extends into the inside space at least approximately axially from the opening and from the flange, this entrance/exit space being part of a communication space between the two combined chambers and able to make it possible to have certain contents pass into/out of the inside space, from one to the other of the two chambers,   An inside critical annular line of contamination risk existing on the outside surface of the panel in contact with the external environment and not overlapped by the outside surface of the panel, when the panels are flattened against one another.       

     This chamber is such that:
         On the one hand, the carrying means and the movement actuation means are arranged so that in the open state of the panel, the panel is substantially separated beyond the boundary of the entrance/exit space, an empty separation space thus being made between the entrance/exit space and the panel in the open state, beyond the lateral boundary and the distal end boundary of the entrance/exit space opposite the opening and the flange;   And, on the other hand, the carrying means and the movement actuation means, structurally integrated into the door, constitute means for protection against the risks of contamination for the inside critical line constituted by the separation space of appropriate size formed and placed between the entrance/exit space and the inside critical annular line, so that the certain contents normally cannot reach the panel during their passage into the entrance/exit space.       

     According to a characteristic, the door is supported by means of carrying means, so that the panel is arranged and mounted so as to be able to be moved to be in the open state either in a primary open state where a primary separation space is made or in a final open state where a final separation space is made that is larger than the primary separation space. 
     Thus, the (first) panel of the (first) door of the (first) chamber is able to be separated from the passage of the certain contents from one to the other of the two chambers; this passage is separated so as to facilitate the transfer of the certain contents, and consideration can be given to having a (first) opening larger than those currently known up to the present, the (first) panel being itself also larger, without prejudice to the passage and the transfer of the certain contents. 
     As appropriate, the separation space is an empty space or, on the contrary, the chamber also comprises a stationary or movable separation wall that, in the open state of the panel, is placed and extends, at least partly, between the panel and the entrance/exit space. In the latter case, this movable separation wall can be structurally combined with the door and/or with its carrying or actuation means. 
     According to an embodiment, in the open state of the panel, the separation between any area of the panel and the closest boundary of the entrance/exit space is at least equal to one-fourth of the size of the entrance/exit space computed in the direction of this separation. More especially, this separation is at least equal to half of the size of the entrance/exit space computed in the direction of this separation. Even more especially, this separation is at least equal to the size of the entrance/exit space computed in the direction of this separation. 
     As appropriate, in the open state of the panel, the panel is placed in a position at least approximately parallel or at least approximately orthogonal to the opening, the flange, and the position of the panel in the closed state, or, respectively, in a position at least approximately orthogonal or at least approximately parallel to the axis of the entrance/exit space. 
     According to an embodiment, in the open state of the panel, the panel is placed in a position at least approximately facing the opening, the flange, and the position of the panel in the closed state. According to another embodiment, it is placed in a lateral position in relation to the opening, the flange, and the position of the panel in the closed state. 
     According to a characteristic, the carrying means and the movement actuation means of the door are arranged to be able to move the panel between its closed and open or primary open states, in a movement comprising an initial movement of separation of the panel from the flange, which is a movement at least approximately of initial translation along an axis that is at least approximately orthogonal to the opening, the flange, and the position of the panel in the closed state, or a movement of initial rotation around an axis that is at least approximately parallel to the opening, the flange, and the position of the panel in the closed state. 
     According to a characteristic, the carrying means and the movement actuation means of the door are arranged to be able to move the panel between its closed and open or primary open and final open states, in a movement comprising an initial movement of separation of the panel from the flange and at least one subsequent movement that is a subsequent translational movement and/or at least a subsequent rotational movement. 
     According to different possibilities, the carrying means and the movement actuation means of the door are arranged to be able to move the panel in a subsequent translational movement along an axis of translation that is at least approximately rectilinear, particularly at least approximately parallel to, or at least approximately orthogonal to, or inclined in relation to the opening, the flange, and the position of the panel in the closed state or along a curvilinear axis of translation. 
     According to other possibilities, the carrying means and the movement actuation means of the door are arranged to be able to move the panel in a subsequent rotational movement around an axis that is at least approximately parallel to, or at least approximately orthogonal to, the opening, the flange, and the position of the panel in the closed state. 
     For this purpose, and according to the different possibilities mentioned above, the carrying means and the movement actuation means of the door comprise means for initial separation of the panel from the flange that are translational means along an axis that is at least approximately orthogonal to the opening, the flange, and the position of the panel in the closed state, or rotational means around an axis that is at least approximately parallel to the opening, the flange, and the position of the panel in the closed state. These carrying means and these movement actuation means of the door comprise means for initial separation of the panel from the flange and subsequent movement means that are translational means and/or rotational means. 
     According to different possibilities, the carrying means and the movement actuation means of the door comprise subsequent movement means of translation along an axis of translation that is at least approximately rectilinear or curvilinear, in particular at least approximately parallel to, or at least approximately orthogonal to, or inclined in relation to the opening, the flange, and the position of the panel in the closed state. 
     According to other possibilities, the carrying means and the movement actuation means of the door comprise means of subsequent rotation around an axis that is at least approximately parallel to, or at least approximately orthogonal to, the opening, the flange, and the position of the panel in the closed state. 
     According to an embodiment, the panel of the door is extended laterally in projection, in at least approximately coplanar fashion, by at least one mechanism plate that is part of the carrying means and that makes possible the movement of the panel as a result of the implementation of the movement actuation means. 
     According to an embodiment, the wall comprises one or more through slots suited to the sealed and aseptic passage of the carrying means and/or of the movement actuation means of the door. 
     According to a first variant embodiment, the carrying means and the movement actuation means of the door are arranged to be able to move the panel from its closed state in a movement comprising an initial translational movement along an axis that is at least approximately orthogonal to the opening, the flange, and the position of the panel in the closed state, to separate the panel from the flange, and at least a subsequent translational movement along an axis that is at least approximately parallel to the opening, the flange, and the position of the panel in the closed state, and/or a rotational movement around an axis that is at least approximately orthogonal to the opening, the flange, and the position of the panel in the closed state, to bring the panel into its position in the open or primary open or final open state where it is then placed in a lateral position in relation to the opening, the flange, and the position of the panel in the closed state, at least approximately orthogonal to the axis of the entrance/exit space, the separation space being located beyond the lateral boundary of the entrance/exit space. 
     In this first variant, the carrying means and the movement actuation means of the door can comprise at least a first actuator placed along an axis that is at least approximately orthogonal to the opening, the flange, and the position of the panel in the closed state and that ensures the initial translational movement and either at least a second actuator along an axis that is at least approximately parallel to the opening, the flange, and the position of the panel in the closed state, or at least a system of rotational movement along an axis that is at least approximately orthogonal to the opening, the flange, and the position of the panel in the closed state. 
     In this first variant, the course of initial translational movement can be just that necessary, aside from the necessary degrees of play, to make possible the subsequent translational movement or rotational movement, without the panel interfering with the wall of the chamber on its inside surface. 
     In this first variant, in its open or primary open or final open state, the outside surface of the panel can be turned toward and close to the inside surface of the wall of the chamber. 
     In this first variant, the panel of the door can be laterally extended in projection, in at least approximately coplanar fashion, by at least one mechanism plate supported at least approximately orthogonally by the at least one first actuator that passes through the at least one through slot of the wall, the at least one first actuator being supported by the at least one second actuator or the at least one system of rotational movement. 
     According to a second variant embodiment, the carrying means and the movement actuation means of the door are arranged to be able to move the panel from its closed state in a movement comprising at least one translational movement along an axis that is at least approximately orthogonal to the opening, the flange, and the position of the panel in the closed state, to separate the panel from the flange, and then to bring the panel into its position in the open, primary open, or final open state, where it is then placed in a position at least approximately facing the opening, the flange, and the position of the panel in the closed state, at least approximately orthogonal to the axis of the entrance/exit space, the separation space being located beyond the end boundary of the entrance/exit space opposite the opening and the flange. 
     In this second variant, the carrying means and the movement actuation means of the door can comprise at least one actuator placed along an axis that is at least approximately orthogonal to the opening, the flange, and the position of the panel in the closed state. 
     In this second variant, the course of translational movement can be that necessary to produce the separation space. 
     In this second variant, in its open or primary open or final open state, the outside surface of the panel can be turned toward and removed from the opening and the flange. 
     In this second variant, the panel of the door can be laterally extended in projection, in at least approximately coplanar fashion, by at least one mechanism plate supported at least approximately orthogonally by the at least one actuator. 
     According to a third variant embodiment, the carrying means and the movement actuation means of the door are arranged to be able to move the panel from its closed state in a movement comprising a rotational movement around an axis that is at least approximately parallel to the opening, the flange, and the position of the panel in the closed state, to bring the panel into its position in the open or primary open or final open state where it is then placed in a lateral position in relation to the opening, the flange, and the position of the panel in the closed state, at least approximately orthogonal to the axis of the entrance/exit space, the separation space being located beyond the lateral boundary of the entrance/exit space. 
     In this third variant, the carrying means and the movement actuation means of the door can comprise at least one system of rotational movement along an axis that is at least approximately parallel to the opening, the flange, and the position of the panel in the closed state. 
     In this third variant, the course of rotational movement may be close to that of a half-turn. 
     In this third variant, in its open or primary open or final open state, the outside surface of the panel can be turned opposite the inside surface of the wall of the chamber. 
     In this third variant, the panel of the door can be laterally extended in projection, in at least approximately coplanar fashion, by a mechanism plate supported by the system of rotational movement. 
     According to a fourth variant embodiment, the carrying means and the movement actuation means of the door are arranged to be able to move the panel from its closed state in a movement comprising a translational movement along a curvilinear axis corresponding at least approximately to an arc with an axis that is at least approximately parallel to the opening, the flange, and the position of the panel in the closed state. 
     In this fourth variant, the carrying means and the movement actuation means of the door comprise at least one deformable parallelogram system along an axis that is at least approximately parallel to the opening, the flange, and the position of the panel in the closed state. The course of rotational movement of the deformable parallelogram is, for example, on the order of a half-turn. 
     In this fourth variant, in its open or primary open or final open state, the outside surface of the panel is turned toward the inside surface of the wall of the chamber. 
     According to another characteristic, the chamber is especially designed for the biopharmaceutical field, and it comprises an opening having a diameter that is larger than 40 centimeters. 
     According to a second aspect, the invention has as its object a sealed junction device between a first chamber and a second chamber that are isolated from the external environment, such that the first chamber is a chamber as has just been described, the second chamber comprising:
         A second structure that includes a second closed wall that borders a second inside space,   At least a second opening made in the second wall and bordered by a second annular flange whose outside surface is able to be flattened in a hermetically-sealed fashion onto the outside surface of the first complementary flange that is part of the first chamber,   Removable holding means, at least partly combined with the second flange, able to hold in a removable way the second flange and the first flange flattened against one another by their outside surfaces,   A second door whose panel is arranged and mounted so as to be able to be moved to be either in the closed state where it works with the second flange while closing the second opening or in the open state where it is separated from the second flange while opening the second opening, and whose outside surface is able to be flattened in a hermetically-sealed fashion onto the outside surface of the panel of the first complementary door that is part of the first chamber,   Removable interlocking means at least partly combined with the second door, able to hold—in a removable way—the panel of the second door and the panel of the first door that are flattened against one another by their outside surfaces,   So that when the panels of the first door and the second door are in the open state, the first chamber and the second chamber are in communication with one another by their openings, a communication space that includes the entrance/exit space being made between the two chambers and making it possible to pass certain contents from one to the other,   An inside critical annular line of contamination risk existing on the panel of the first door and an outside critical annular line of contamination risk existing on the second flange, the carrying means and the movement actuation means of the first door, structurally integrated into the first door, are such that when the panel of the first door and the panel of the second door are in the open state, a separation space appearing in the form of an empty space of appropriate size is formed and placed between the communication space and the inside critical annular line, the panel of the first door being substantially separated from the entrance/exit space.       

     According to an embodiment, the sealed junction device between a first chamber and a second chamber that are isolated from the external environment also comprises means that are structurally integrated into the second flange, able—when the panels of the first door and the second door are in the open state—to form a separation between the communication space and the outside critical annular line. 
     According to an embodiment, the sealed junction device between a first chamber and a second chamber that are isolated from the external environment is such that the means that are structurally integrated into the first door and/or into the second flange are entirely integrated into the first door and/or the second flange. 
     According to a third aspect, the invention has as its object a sealed transfer device between a first chamber, such as has been previously described, and a second chamber that are isolated from the external environment, comprising a sealed junction device between the two chambers as has just been indicated. 
    
    
     
       BRIEF DESCRIPTION OF THE DRAWINGS 
       Now, several embodiments of the invention are described with drawings, in which: 
         FIG. 1  is a cutaway view, in a cutaway through an axial plane, of a sealed junction device between a first chamber and a second chamber that are partially shown, whereas the two chambers are close to one another but not yet flattened, the panels of the two doors of the two chambers being in the closed state, the sealed junction device comprising means that are structurally integrated into the first door able to form a separation space between the entrance/exit space and the first panel, the carrying means and the movement actuation means of the first door being arranged to be able to move the first panel from its closed state in an initial translational movement along an axis orthogonal to the first opening, the first flange, and the first panel when it is in the closed state and a subsequent rotational movement around an axis that is orthogonal to the first opening, the first flange, and the first panel when it is in the closed state. 
         FIG. 2  is a diagram corresponding to  FIG. 1 , whereas the two flanges and the panels of the two doors of the two chambers are applied to one another, the panels of the doors of the two chambers being in the closed state. 
         FIG. 3  is a diagram similar to  FIG. 2 , whereas the second flange is joined to the first flange and the panel of the second door joined to the panel of the first door, once the initial translational movement is performed but before the subsequent rotational movement is performed, the panel of the first door and the panel of the second door being separated from the first flange, without the panel of the first door being already in the fully open state. 
         FIG. 4  is a diagram similar to  FIGS. 2 and 3 , once the rotational movement is partially but not completely performed, the panel of the first door not yet being in the fully open state. 
         FIG. 5  is a diagram similar to  FIGS. 2 to 4 , once the rotational movement is completely performed, the panel of the first door being in the open state, like the panel of the second door, where it is placed in a lateral position in relation to the first opening, the first flange, and the first panel when it is in the closed state, at least approximately orthogonal to the axis of the entrance/exit space, the separation space being located beyond the lateral boundary of the entrance/exit space. 
         FIGS. 6A ,  6 B and  6 C are three diagrams in cutaway illustrating carrying means and movement actuation means of the first door able to move the first panel in an initial translational movement and a subsequent rotational movement. 
         FIGS. 7A ,  7 B,  7 C and  7 D are four diagrams in elevation, from the interior of the first chamber, the first opening, and the panel of the first door, respectively whereas the first panel is in the closed state ( FIGS. 1 and 2 ), is separated from the first opening and from the first flange without yet being in the fully open state ( FIG. 3 ), has been partially pivoted ( FIG. 4 ), has been fully pivoted, and is in the open state ( FIG. 5 ). 
         FIGS. 8A ,  8 B, and  8 C are three views in partial perspective, from the interior of the first chamber, corresponding to  FIGS. 7A ,  7 B, and  7 C, in the case where the separation space is an empty space. 
         FIGS. 9A ,  9 B, and  9 C are three views similar to  FIGS. 8A ,  8 B, and  8 C in the case where the chamber also comprises a stationary separation wall that in the open state of the first panel is placed and extends between the first panel and the entrance/exit space. 
         FIG. 10  is a diagram corresponding to  FIG. 2  of a sealed junction device between a first chamber and a second chamber that are partially shown, whereas the two flanges and the panels of the two doors of the two chambers are applied to one another, the panels of the doors of the two chambers being in the closed state, the sealed junction device comprising, in this embodiment, means structurally integrated into the first door and able to form a separation space between the entrance/exit space and the first panel, the carrying means and the movement actuation means of the first door being arranged to be able to move the first panel from its closed state in an initial translational movement along an axis that is at least approximately orthogonal to the first opening, the first flange, and the first panel when it is in the closed state, and a subsequent translational movement along an axis parallel to the first opening, the first flange, and the first panel when it is in the closed state. 
         FIG. 11  is a diagram similar to  FIG. 10 , whereas the second flange is joined to the first flange and the panel of the second door joined to the panel of the first door, once the initial translational movement is performed but before the subsequent translational movement is performed, the panel of the first door being separated from the first opening and from the first flange, without yet being in the fully open state. 
         FIG. 12  is a diagram similar to  FIGS. 10 and 11 , once the translational movement is completely performed, the panel of the first door being in the open state, like the panel of the second door, where it is placed in a lateral position in relation to the first opening, the first flange, and the first panel when it is in the closed state, at least approximately orthogonal to the axis of the entrance/exit space, the separation space being located beyond the lateral boundary of the entrance/exit space. 
         FIGS. 13A ,  13 B and  13 C are three diagrams in elevation, from the interior of the first chamber of the first opening and of the panel of the first door, respectively, whereas the first panel is in the closed state ( FIG. 10 ), is separated from the first flange without yet being in the fully open state ( FIG. 11 ), has been fully slid, and is in the open state ( FIG. 12 ). 
         FIG. 14  is a diagram corresponding to  FIGS. 2 and 10  of a sealed junction device between a first chamber and a second chamber that are partially shown, whereas the two flanges and the panels of the two doors of the two chambers are applied to one another, the panels of the doors of the two chambers being in the closed state, the sealed junction device comprising, in this embodiment, means structurally integrated into the first door able to form a separation space between the entrance/exit space and the first panel, the carrying means and the movement actuation means of the first door being arranged to be able to move the first panel from its closed state in a translational movement along an axis orthogonal to the first opening, the first flange, and the first panel when it is in the closed state. 
         FIG. 15  is a diagram similar to  FIG. 14 , whereas the second flange is joined to the first flange and the panel of the second door is joined to the panel of the first door, once the translational movement is partially but not completely performed, the panel of the first door not yet being in the fully open state. 
         FIG. 16  is a diagram similar to  FIGS. 14 and 15 , once the translational movement is completely performed, the panel of the first door being in the open state, like the panel of the second door, where it is located in a position at least approximately facing the first opening, the first flange, and the position of the first panel in the closed state, at least approximately orthogonal to the axis of the entrance/exit space, the separation space being located beyond the end boundary of the entrance/exit space opposite the first opening and the first flange. 
         FIG. 17  is a diagram corresponding to  FIGS. 2 ,  10  and  14  of a sealed junction device between a first chamber and a second chamber that are partially shown, whereas the two flanges and the panels of the two doors of the two chambers are applied to one another, the panels of the doors of the two chambers being in the closed state, the sealed junction device comprising, in this embodiment, means structurally integrated into the first door able to form a separation space between the entrance/exit space and the first panel, the carrying means and the movement actuation means of the first door being arranged to be able to move the first panel, supporting the second panel, from its closed state in a rotational movement around an axis that is parallel to the first opening, the first flange, and the first panel when it is in the closed state. 
         FIG. 18  is a diagram similar to  FIG. 17 , whereas the second flange is joined to the first flange and the panel of the second door is joined to the panel of the first door once the rotational movement is partially but not completely performed, the panel of the first door not yet being in the fully open state. 
         FIG. 19  is a diagram similar to  FIGS. 17 and 18 , once the rotational movement is completely performed, the panel of the first door being in the open state, like the panel of the second door, where it is placed in a lateral position in relation to the first opening, the first flange, and the first panel when it is in the closed state, at least approximately orthogonal to the axis of the entrance/exit space, the separation space being located beyond the lateral boundary of the entrance/exit space. 
         FIG. 20  is a view in axial cutaway of the panel of the first door in a variant comprising also a separation wall in the form of an annular deflector integrated into the first door. 
         FIG. 21  is a perspective view corresponding to  FIG. 20 , from the interior of the first chamber. 
         FIG. 22  is a diagram in perspective of a sealed junction device according to a fourth variant embodiment where the carrying means and the movement actuation means of the first door are arranged to be able to move the first panel, supporting the second panel, from its closed state in a translational movement along a curvilinear axis corresponding at least approximately to an arc with an axis that is at least approximately parallel to the opening, the flange, and the position of the panel in the closed state, the carrying means and the movement actuation means of the door comprising at least one deformable parallelogram system. 
         FIG. 23  is a cutaway diagram of the device according to the fourth variant of  FIG. 22 , when it is in the closed state, in two intermediate open states and in the open state. 
     
    
    
     DETAILED DESCRIPTION OF THE INVENTION 
     A sealed and aseptic transfer device between a chamber  1  (first chamber  1 ) and another chamber  2  (second chamber  2 ) such as the one considered here is called “double-door.” By way of example, but not limiting, such a device is of the general type of that known in the art under the trademark BIOSAFE® and described in the document EP-A-0688020. 
     Such a transfer can be necessary in a number of technical fields, particularly but not exclusively the biopharmaceutical field. 
     The chamber  1  (first chamber)—for example stationary, rigid and of relatively large size—comprises a structure that includes a first closed wall  3 , solid and rigid, but equipped with a first opening  4 , itself bordered by a first annular flange  5 , with outside surface  5   a , both the opening  4  and the flange  5  being, for example, circular, this embodiment not being limiting. According to an embodiment, the first wall is vertical or inclined vertically by an angle on the order of 30° to 45°. The wall  3 , having an inside surface  3   b , borders the inside space  1   a  of the chamber  1 . 
     That which is in or toward the inside space  1   a  bordered by the wall  3  is termed “interior” in connection with the first chamber  1 . That which is outside of its inside space  1   a  bordered by the wall  3  is termed “outside” in connection with the first chamber  1 . 
     The first chamber  1  also comprises a first door  6  supported by the structure, particularly by the wall  3 , by means of carrying means  11   a  that are movable or deformable. The panel  6   v  of the first door  6  (or first panel  6   v ) is mounted to move in relation to the first flange  5  forming a seat, and arranged to be moved and brought either to the closed state where it works with the flange  5  by closing the opening  4  or to the open state where it is separated from the flange  5  and placed in the inside space  1   a  by opening the opening  4 . By synecdoche, it will be said that the first door  6  is mounted to move in relation to the first flange  5  to be in the closed state or in the open state, where, respectively, it closes or opens the first opening  4 . The panel  6   v  comprises an outside surface  6   a.    
     If applicable, the first chamber  1  comprises several first doors such as the first door  6 , the transfer device being part of an operating line able to make it possible to perform one or more operations before and/or after the transfer, such as manufacturing, treatment, handling, use, measurement, monitoring, analysis, or the like . . . . 
     The second chamber  2 —for example a disposable movable pocket that is at least partially flexible and of a smaller size—comprises a structure that includes a closed second wall  7 , solid and flexible, but equipped with a second opening  8 , itself bordered by a second annular flange  9 , with outside surface  9   a , both the opening  8  and the flange  9  being, for example, circular, this embodiment not being limiting. The wall  7  borders the inside space  2   a  of the chamber  2 . 
     That which is in or toward its inside space  2   a  bordered by the wall  7  is termed “interior” in connection with the second chamber  2 . That which is outside of its inside space  2   a  bordered by the wall  7  is termed “outside” in connection with the second chamber  2 . 
     The second chamber  2  also comprises a second door  10 , having a second panel  10   v , with outside surface  10   a  and inside surface  10   b . The panel  10   v , mounted to move in relation to the second flange  9  forming a seat, and arranged to be in the closed state or in the open state, where, respectively, it closes or opens the second opening  8 . As above, by synecdoche, it will be said that the second door  10  is mounted to move in relation to the second flange  9  to be in the closed state or in the open state where, respectively, it closes or opens the second opening  8 . 
     The aseptic and sealed transfer device is such that when necessary, several second chambers such as the second chamber  2  can be combined with the same first chamber  1 , successively if the first chamber  1  comprises a single opening and a single door  4  and  6  and/or simultaneously if the first chamber  1  comprises several openings and doors  4  and  6 . 
     One of the chambers  1 ,  2 , originally contains the certain contents C. For example, the certain contents C are originally in the first chamber  1  or in the second chamber  2 , the transfer having as its object to bring it finally, respectively, into the second chamber  2  or into the first chamber  1 , and by doing this to pass the certain contents into a communication space  13  made between the two chambers  1  and  2 . 
     The certain contents C have the characteristic of having the purpose to, and therefore being able to, be transferred via the communication space  13 . In the biopharmaceutical field, the certain contents can be, for example, a sterile object such as a receptacle, a receptacle element such as a stopper, a syringe, but also elements for environmental testing, and indeed even waste produced during manufacturing or treatment operations, waste that it is a matter of transferring to eliminate it . . . . 
     Transfers, such as those considered here, occur within the framework of more complex processes in which the certain contents C undergo one or more operations before and/or after the transfer. These operations consist of manufacturing, treatment, handling, use, measurement, monitoring, analysis, or the like, the requirement of asepsis having to be met. 
     On the other hand, it is important that the transfer of the certain contents C via the communication space  13  not be impeded by the panel  6   v  of the first door  6  in the open state, that the certain contents C not deteriorate this first panel  6   v , and, conversely, that this first panel  6   v  not deteriorate the certain contents C, therefore that the certain contents C cannot reach the first panel  6   v  during their transfer. 
     The invention has as its object both the first chamber  1  as well as the sealed junction device and the transfer device that contains it. 
     The first flange  5 , the first door  6  (more precisely the panel  6   v ), the second flange  9  and the second door  10  (more precisely the panel  10   v ) each have an inside surface located toward the interior, respectively, of the first chamber  1 , of the second chamber  2 , and an outside surface  5   a ,  6   a ,  9   a ,  10   a  in contact with the environment that is external to the two chambers. 
     The first flange  5  and the second flange  9  are complementary to one another structurally as well as functionally. They are arranged so as to be able to be held—in a removable way—flattened against one another by their outside surfaces  5   a  and  9   a , hermetically sealed, while thus being isolated from the external environment. 
     For this purpose, provision is made to equip the flanges  5  and  9  with joining means such as, for example, the complementary shapes given to their respective surfaces  5   a  and  9   a  that must be flattened against one another and one or more seals on the second flange  9 . 
     On the other hand, provision is made to combine a removable interlocking mechanism, for example having cams, not shown, with the flanges  5  and  9 . 
     The first door  6  and the second door  10 —more precisely their panels  6   v  and  10   v —are complementary to one another structurally as well as functionally. They are arranged so as to be able to be flattened against one another by the outside surfaces  6   a  and  10   a  of their respective panels  6   v  and  10   v , hermetically-sealed, while thus being isolated from the external environment. 
     For this purpose, provision is made to equip the doors  6  and  10 —more precisely their panels  6   v  and  10   v —with joining means such as, for example, the complementary shapes given to their respective outside surfaces  6   a  and  10   a  that must be flattened against one another and one or more seals. 
     Movement actuation means  11   b  are also provided that are able to move the first door  6 —more precisely its panel  6   v —between its closed and open states. 
     Monitoring means  11   c  of the movement actuation means  11   b  are also provided. 
     The carrying means  11   a  that are movable or deformable, the movement actuation means  11   b , and the monitoring means  11   c  are integrated into one another and integrated into the first door  6 . 
     Removable interlocking means are also provided that are combined with the two doors  6  and  10 , not shown, able to hold—in a removable way—the two doors  6  and  10 —more precisely their panels  6   v  and  10   v —flattened against one another. 
     It is understood that the first door  6 —more precisely the first panel  6   v —can pass by and be in an intermediate open state, but not fully open ( FIGS. 3 ,  4 ,  8 B,  9 B,  11 ,  15 ,  18 ,  20 ,  21 ). 
     When the first panel  6   v  is in the closed state, it works with the first opening  4 , so that the first opening  4 , the first flange  5 , and the first panel  6   v  in the closed state are approximately coplanar except for the thicknesses, the first panel being retracted, in the sense that it does not substantially project from the first wall  3 . 
     When the two doors  6  and  10 , respectively the two panels  6   v  and  10   v , are in the open state, there is made between the chambers  1  and  2  a communication space  13  having a general shape corresponding to that of a truncated cylinder with an axis AA passing by the edge of the openings  4  and  8  or a shape close to that of such a truncated cylinder, for example a double truncated cone shape or double truncated pyramid shape having a small median base corresponding to the edge of the openings  4  and  8  and two large bases on either side, respectively in the chambers  1  and  2 , particularly in the inside space  1   a  away from the first opening  4 . 
     The communication space  13  comprises an entrance/exit space  13   a  in/of the inside space  1   a  of the first chamber  1 . 
     This entrance/exit space  13   a  has a general shape of a truncated cylinder, cone, or pyramid, extending into the inside space  1   a  at least approximately axially with axis AA, from the opening  4  and the flange  5 . 
     This entrance/exit space  13   a , shown diagrammatically, is virtually bordered by a proximal end boundary formed by the first opening  4  and the first flange  5 , by a distal end boundary  13   b  opposite the first opening  4  and the first flange  5 , and by a lateral boundary  13   c  between the distal and proximal end boundaries  13   b.    
     The sealed junction device exhibits in operation what one skilled in the art knows by the term of critical line. 
     An inside critical line LCi is found on the outside surface  6   a  of the panel  6   v  of the first door  6  in contact with the external environment and not overlapped by the outside surface  10   a  of the panel  10   v  of the second door  10 , when the panels  6   v  and  10   v  of the two doors  6  and  10  are applied against one another. 
     An outside critical line LCe is found on the outside surface  9   a  of the second flange  9  in contact with the external environment and not overlapped by the outside surface  5   a  first flange  5 , when the flanges  5  and  9  are applied against one another. 
     These critical lines LCi and LCe constitute areas where there is a risk of contamination because they are in contact with the external environment. 
     These critical lines LCi and LCe are therefore unavoidable because it is impossible that the panel  10   v  of the second door  10  completely overlaps the panel  6   v  of the first door  6  and that the outside surface  5   a  of the first flange  5  completely overlaps the outside surface  9   a  of the second flange  9 , even if the shape and size of the flanges  5  and  9  and of the panels  6   v  and  10   v  of the doors  6  and  10 , respectively, are selected so that these critical lines LCi and LCe are minimal. 
     The first chamber  1  is such that the carrying means  11   a  and the movement actuation means  11   b  of the first door  6  are arranged so that in the open state of the first panel  6   v , the first panel  6   v  is substantially separated beyond the boundary  13   b ,  13   c  of the entrance/exit space  13   a , a separation space  12  being thus made between the boundary  13   b ,  13   c  of the entrance/exit space  13   a  and the first panel  6   v  in the open state. 
     According to the conceivable embodiments, the separation space  12  is located beyond the lateral boundary  13   c  of the entrance/exit space  13   a  ( FIGS. 5 ,  8 C,  9 C,  12 ,  13 C,  19 ,  22 ,  23 ) or is located beyond its distal end boundary  13   b  ( FIG. 16 ). 
     “Substantially separated” is defined as the fact that the first panel  6   v  is removed and separated outside of the boundary  13   b ,  13   c  of the entrance/exit space  13   a , and that between any area of the first panel  6   v  and the closest boundary  13   b ,  13   c  of the entrance/exit space  13   a , there exists an interval that constitutes a distance  e  that, on the scale of the size  E  of the entrance/exit space  13   a  computed in the direction of this interval where this distance  e  is computed, not only is not insignificant but in fact is noteworthy and noticeable. 
     When the separation space  12  is located beyond the lateral boundary  13   c  of the entrance/exit space  13   a , the direction in which  e  and  E  are computed is a direction that is orthogonal to the axis AA. When the separation space  12  is located beyond the distal end boundary  13   b  of the entrance/exit space  13   a , the direction in which  e  and  E  are computed is the axial direction AA. 
     In the applications more particularly considered where the first opening  4  has a diameter on the order of 10 to 40 centimeters, E can be of the same order of magnitude (10 to 40 centimeters), and the separation  e  that constitutes the separation space  12  can be between a minimal value on the order of 3 and able to go up to 40 centimeters. As indicated, the invention also relates to the case of a first chamber  1  especially designed for the biopharmaceutical field whose opening  4  (and therefore the panel  6   v ) has a diameter that is larger than the current diameters, let us say a diameter that is larger than 40 centimeters. 
     Although the separation  e  is not directly dictated size E, it is shown that the separation  e  can be at least equal to one-fourth of  E , or even at least equal to half of E, or even at least equal to  E . 
     The word “diameter” must be understood as the largest width of the first opening  4 , this opening not being necessarily circular. 
     “Open state of the first panel  6   v ” is defined as the state in which the separation space  12  is made as has just been defined or a primary open state where a primary separation space  12  is made as has just been defined, the first panel  6   v  also being able to be in a final open state in which an interval that constitutes a distance that is larger than that of the primary open state is made between it and the entrance/exit space  13   a.    
     With the structure described, the carrying means  11   a  and the movement actuation means  11   b , structurally integrated into the first door  6 , constitute means for protection against the risks of contamination for the inside critical line (LCi). Such protection means consist of the separation space  12  formed as has been set forth and placed between the entrance/exit space  13   a  and the inside critical line (LCi). This separation space  12  has an appropriate size, as has been set forth, so that the certain contents C normally cannot reach the first panel  6   v  during their passage into the entrance/exit space  13   a . That is how the separation space  12  forms protection means of the inside critical line (LCi). 
     Consequently, the sealed junction device comprises means  11   a ,  11   b  that are structurally integrated—particularly fully integrated—into the first door  6 , able—when the first door  6  and the second door  10  are in the open state—to form a separation—namely the separation space  12 —between the communication space  13  and the inside critical annular line LCi. 
     According to a possible embodiment, not shown, the sealed junction device also comprises means that are structurally integrated—particularly fully integrated—into the second flange  9  that are able—when the first door  6  and the second door  10 , more precisely their panels  6   v  and  10   v , are in the open state—to form a separation between the communication space  13  and the outside critical annular line LCe. 
     Such means that are structurally integrated into the second flange  9  come, for example, in the form of an annular deflector integrated into the second flange  9 , bordering the second opening  8  and projecting from the free frontal plane of the second flange  9  that forms an interface with the first flange  5 . 
     The sealed transfer device that incorporates the sealed junction device therefore comprises, also, the means able—when the first door  6  and the second door  10 , more precisely their panels  6   v  and  10   v , are in the open state—to form a separation between the communication space  13  and the inside critical annular line LCi and, if applicable, the outside critical annular line LCe. 
     Integrated—relative to the means  11   a  and  11   b  and the first door  6 —is defined as the fact that these means  11   a  and  11   b  are, respectively, incorporated into or still included in the first door  6 , so as to form a coherent whole with it. In other words, the means  11   a  and  11   b  are not, respectively, extraneous to, attached to, or exterior to the door  6 . 
     To express that the certain contents C normally cannot reach the inside critical line LCi, if applicable the outside critical line LCe, during their passage into the entrance/exit space  13   a , more generally the communication space  13 , signifies that when the certain contents C are passed from one chamber to the other  1 ,  2 , under normal conditions of use of the sealed transfer device, the certain contents C do not come into contact with the critical line LCi, LCe. Normal conditions of use of the sealed transfer device are defined as the fact that the certain contents C are transferred along the path matched to the shape of the communication space  13 , for example in the median part of this space. 
     According to the conceivable embodiments, the separation space  12  is an empty space ( FIGS. 5 ,  8 C,  12 ,  16 ,  19 ,  22  and  23 ) or else the chamber  1  also comprises a stationary or movable separation wall  14 ,  25  that, in the open state of the first panel  6   v , is placed and extends, at least partly, between the first panel  6   v  and the entrance/exit space  13   a  ( FIG. 9C ). 
     According to the conceivable embodiments, such a separation wall  14  is stationary ( FIGS. 9A ,  9 B and  9 C) or such a separation wall  25  is movable ( FIGS. 20 and 21 ). 
     According to a conceivable embodiment ( FIGS. 9A ,  9 B and  9 C), such a separation wall  14  can be structurally combined with the structure of the first chamber  1 , particularly with the first wall  3 , in which case the separation wall can be stationary and form with the wall  3  a protective cavity  14   a  of the inside critical line LCi. 
     According to another conceivable embodiment ( FIGS. 20 and 21 ), such a separation wall  25  can be structurally combined with the first door  6  and/or with its carrying means  11   a  or movement actuation means  11   b , in which case the separation wall  25  is movable. For example, there can be provided an annular deflector  25  integrated into the first door  6 , supported by or being part of the carrying means  11   a  or the first panel  6   v . Such a cylindrical annular deflector  25  forms—with a central part  33  of carrying means  11   a —a protective cavity  34  of the inside critical line LCi, with an axial size that is larger, particularly considerably larger, than the axial space requirement of the first panel  6   v  or than the axial space requirement of the assembly comprising the first panel  6   v  and the second panel  10   v  flattened on the first panel  6   v.    
     According to the embodiments shown, the first panel  6   v  in the open state is placed in a position at least approximately parallel to the first opening  4 , the first flange  5 , and the first panel  6   v  when it is in the closed state. In this case, the first panel  6   v  is placed in a position at least approximately orthogonal to the axis AA of the entrance/exit space  13   a.    
     According to another embodiment, not shown, the first panel  6   v  in the open state is placed in a position at least approximately orthogonal to the first opening  4 , the first flange  5 , and the first panel  6   v  when it is in the closed state. In this case, the first panel  6   v  is placed in a position at least approximately parallel to the axis AA of the entrance/exit space  13   a.    
     According to the embodiment shown in  FIG. 16 , the first panel  6   v  in the open state is placed in a position at least approximately facing the first opening  4 , the first flange  5 , and the position of the first panel  6   v  in the closed state. This embodiment corresponds to the case where the separation space  12  is located beyond the distal end boundary  13   b  of the entrance/exit space  13   a.    
     According to the embodiments shown in  FIGS. 5 ,  8 C,  9 C,  12 ,  19 ,  22  and  23 , the first panel  6   v  in the open state is placed in a lateral position in relation to the first opening  4 , the first flange  5 , and the first panel  6   v  when it is in the closed state. This embodiment corresponds to the case where the separation space  12  is located beyond the lateral boundary  13   c  of the entrance/exit space  13   a.    
     It is understood that when the first chamber  1  is combined with a second chamber  2 , within the framework of a sealed junction device and an aseptic transfer device, the first panel  6   v  supports the second panel  10   v , the two panels  6   v  and  10   v  being interlocked, flattened against one another by their respective outside surfaces  6   a  and  10   a  that are in contact. 
     The carrying means  11   a  and the movement actuation means  11   b  of the first door  6 , just like the layout and kinematics of the first door  6 , particularly of its panel  6   a , can be the object of several structurally different embodiments but all having the effect of seeing to it that in the open state of the first panel  6 , the latter is substantially separated beyond the boundary  13   b  of the entrance/exit space  13 , with establishment of the separation space  12 . 
     Generally, the carrying means  11   a  and the movement actuation means  11   b  are arranged to be able to move the first panel  6   v  between its closed and open or primary open states, in a movement comprising an initial movement of separation of the first panel  6   v  from the first flange  5 . 
     In one embodiment, this initial movement of separation is a movement at least approximately of initial translation along an axis that is at least approximately orthogonal to the first opening  4 , the first flange  5 , and the position of the first panel  6   v  in the closed state ( FIGS. 3 ,  8 B,  9 B,  11 ,  15 ). 
     In another embodiment, this initial movement of separation is a movement of initial rotation around an axis that is at least approximately parallel to the first opening  4 , the first flange  5 , and the position of the first panel  6   v  in the closed state ( FIGS. 17 ,  23 ). 
     Not less generally, the carrying means  11   a  and the movement actuation means  11   b  are arranged to be able to move the first panel  6   v  between its closed and open or primary open and final open states, in a movement comprising an initial movement of separation of the first panel  6   v  from the first flange  5 , as has just been indicated, and at least a subsequent movement that is a subsequent translational movement and/or at least a subsequent rotational movement. 
     This subsequent translational movement or rotational movement can be the object of several embodiments. 
     In one embodiment, the axis of translation of the subsequent translational movement is an axis that is at least approximately rectilinear. 
     For example, this axis of translation can be at least approximately parallel to the first opening  4 , the first flange  5 , and the position of the first panel  6   v  in the closed state ( FIG. 12 ). 
     Or, this axis of translation can be approximately orthogonal to the first opening  4 , the first flange  5 , and the position of the first panel  6   v  in the closed state ( FIG. 16 ). 
     Or, according to another embodiment, not shown, this axis of translation can be inclined in relation to the first opening  4 , the first flange  5 , and the position of the first panel  6   v  in the closed state. 
     In another embodiment, the axis of translation of the subsequent translational movement is a curvilinear axis ( FIGS. 22 and 23 ). 
     In another embodiment, the subsequent movement is a rotation around an axis. 
     For example, this axis of rotation can be at least approximately parallel to the first opening  4 , the first flange  5 , and the position of the first panel  6   v  in the closed state ( FIGS. 17 ,  18 ,  19 ,  20 ,  21 ,  22  and  23 ). 
     Or, this axis of rotation can be approximately orthogonal to the first opening  4 , the first flange  5 , and the position of the first panel  6   v  in the closed state ( FIGS. 3 ,  4 ,  7 C and  7 D). 
     The structure and the layout of the carrying means  11   a  and the movement actuation means  11   b  are matched to the desired kinematics. 
     Thus, the carrying means  11   a  and the movement actuation means  11   b  comprise means for initial separation of the first panel  6   v  from the first flange  5  that are means of translation along an axis that is at least approximately orthogonal to the first opening  4 , the first flange  5 , and the position of the first panel  6   v  in the closed state, or means of rotation around an axis that is at least approximately parallel to the first opening  4 , the first flange  5 , and the position of the first panel  6   v  in the closed state, as previously indicated. 
     Likewise, the carrying means  11   a  and the movement actuation means  11   b  comprise such means of initial separation of the first panel  6   v  and of the first flange  5  and means of subsequent movement that are translational means and/or rotational means, as previously indicated. 
     The first panel  6   v  is laterally extended in projection, in an at least approximately coplanar fashion, by one or more mechanism plates  15  that are part of the carrying means  11   a  and that make possible the movement of the first panel  6   v , following the implementation of the movement actuation means  11   b.    
     According to the embodiments, the first wall  3  comprises one or more through slots  16  suited to the sealed and aseptic passage of the carrying means  11   a  and/or of the movement actuation means  11   b.    
     Reference is now more particularly made to  FIGS. 1 to 9C  that illustrate a first mode of execution of the chamber  1  in a first variant embodiment. 
     In this case, the carrying means  11   a  and the movement actuation means  11   b  of the first door  6  are arranged to be able to move the first panel  6   v  from its closed state in a movement comprising an initial translational movement along an axis that is at least approximately orthogonal to the first opening  4 , the first flange  5 , and the first panel  6   v  when it is in the closed state, and this so as to separate the first panel  6   v  from the first flange as has been previously indicated, and at least a subsequent rotational movement around an axis that is at least approximately orthogonal to the first opening  4 , the first flange  5 , and the first panel  6   v  when it is in the closed state, and this so as to bring the first panel into its position in the open or primary open or final open state. 
     In the embodiment of  FIGS. 7A to 7D , the rotational movement is at least approximately a half-turn. In the embodiments of  FIGS. 8A to 8C  and  9 A to  9 C, the rotational movement is at least approximately a quarter-turn. 
     In this open or primary open or final open state, the first panel is placed in a lateral position in relation to the first opening  4 , the first flange  5 , and the first panel  6   v  when it is in the closed state, this position being at least approximately orthogonal to the axis AA of the entrance/exit space  13   a , while the separation space  12  is located beyond the lateral boundary  13   c  of the entrance/exit space  13 . 
     In this first variant embodiment and this first mode of execution, the carrying means  11   a  and the movement actuation means  11   b  of the first door  6  comprise at least one first actuator  17  placed along an axis that is at least approximately orthogonal to the first opening  4 , the first flange  5 , and the first panel  6   v  when it is in the closed state and ensuring the initial translational movement and at least one system  18  of rotational movement along an axis that is at least approximately orthogonal to the first opening  4 , the first flange  5 , and the first panel  6   v  when it is in the closed state. 
     As illustrated in  FIGS. 6A ,  6 B, and  6 C, such a system  18  of rotational movement can comprise a shaft  18   a  having a shaped slot that has an axial part  18   b  and a part  18   c  inclined on the axis of the shaft, with which a pin  18   d  works. 
     In the embodiment shown, the course of initial translational movement performed using the first actuator  17  is just that necessary, aside from the necessary degrees of play, to make possible, on the one hand, the subsequent rotational movement, without the first panel  6   v  and the second panel  10   v  interfering with the first wall  3  of the first chamber  1  on its inside surface  3   b  and, on the other hand, that the inside surface  10   b  of the second door (or more precisely of the panel  10   v  of the second door  10 ) is found in the vicinity of the inside surface  3   b  of the first wall  3 , so as to not occupy a useful part of the inside space  1   a  of the first chamber  1  and to see to it that the inside critical line LCi of the open first door  6  is located toward the inside surface  3   b  of the first wall  3 . 
     In the embodiment shown, the outside surface  6   a  of the first panel  6   v  in its open or primary open or final open state is turned toward and particularly close to the inside surface  3   b  of the first wall  3  of the first chamber  1 . Thus, the inside surface  10   b  of the second panel  10   v  in its open or primary open or final open state is turned toward and located in the proximity, particularly in the immediate proximity, of the inside surface  3   b  of the first wall  3  of the first chamber  1 . 
     In this first variant embodiment and this first mode of execution, the first panel  6   v  of the first door  6  is laterally extended by a mechanism plate  15 , which is supported at least approximately orthogonally to the end of the shaft  18   a , placed along an axis that is at least approximately orthogonal to the first opening  4 , the first flange  5 , and the first panel  6   v  when it is in the closed state. 
     This shaft  18   a  passes through a through slot  16  of the first wall  3 , where the shaped slots  18   b ,  18   c  and the pin  18   d  are provided. 
     The first actuator  17  acts on the shaft  18   a  to cause it to slide along its axis. 
     The shaft  18   a  is laterally offset away from the first opening  4  and the first flange  5 . On the other hand, it is laterally (parallel to the first wall  3 ) separated from the first panel  6   v  of the first door  6  as a result of the presence of the mechanism plate  15 . 
     With a mechanism plate  15  of sufficient length and a sufficient course of rotation, it is possible to make a separation space  12  of sufficiently large size, as indicated. 
     According to one possibility ( FIGS. 8A ,  8 B and  8 C), the panels  6   v  and  10   v  of the two doors  6  and  10  in the open state are simply located in the inside space  1   a  of the first chamber  1 , sufficiently removed from the entrance/exit space  13   a , as indicated. 
     According to another possibility ( FIGS. 9A ,  9 B and  9 C), a protective cavity  14   a  of the panels  6   v  and  10   v  of the two doors  6  and  10  in the open state, whereas they are flattened against one another, is provided in the first chamber  1 . Such a protective cavity  14   a  is made between the inside surface  3   b  of the first wall  3  and a separation wall  14  placed parallel to and separated from it. Such a protective cavity  14   a  comprises an opening for passage of the two panels  6   v  and  10   v  by sliding in their own planes. With such a structure, the distance separation is reinforced by a separation barrier. 
     Reference is now made more particularly to  FIGS. 10 to 13C  that illustrate a second mode of execution of the chamber  1  in the same first variant embodiment. 
     In this case, the carrying means  11   a  and the movement actuation means  11   b  of the first door  6  are arranged to be able to move the first panel  6   v  from its closed state in a movement comprising an initial translational movement as in the first mode of execution previously described and at least one subsequent translational movement along an axis that is at least approximately parallel to the first opening  4 , the first flange  5 , and the first panel  6   v  when it is in the closed state, and this so as to bring the first panel into its position in the open or primary open or final open state. 
     In this open or primary open or final open state, the first panel is placed as in the first mode of execution previously described. 
     In this second mode of execution, the carrying means  11   a  and the movement actuation means  11   b  of the first door  6  comprise at least the first actuator  17  placed along an axis that is at least approximately orthogonal to the first opening  4 , the first flange  5 , and the first panel  6   v  when it is in the closed state and ensuring the initial translational movement and at least a second actuator  19  along an axis that is at least approximately parallel to the first opening  4 , the first flange  5 , and the first panel  6   v  when it is in the closed state. 
     In the embodiment shown, the course of initial translational movement performed using the first actuator  17  is like that of the first mode of execution previously described. 
     In the embodiment shown, the outside surface  6   a  of the first panel  6   v  in its open or primary open or final open state is placed as in the first mode of execution previously described, and likewise for the surfaces of the second panel  10   v.    
     In this second mode of execution, the first panel  6   v  of the first door  6  is also laterally extended by at least one mechanism plate  15 , which is supported at least approximately orthogonally by the first actuator  17  passing through a through slot  16  of the first wall  3 . 
     The first actuator  17  is supported by the second actuator  19 . 
     Reference is now made more particularly to  FIGS. 14 to 16  that illustrate a second variant embodiment of the chamber  1 . 
     In this case, the carrying means  11   a  and the movement actuation means  11   b  of the first door  6  are arranged to be able to move the first panel  6   v  from its closed state in a movement comprising at least a translational movement along an axis that is at least approximately orthogonal to the first opening  4 , the first flange  5 , and the first panel  6   v  when it is in the closed state, and this to separate the first panel  6   v  from the first flange, and then to bring the first panel into its position in the open or primary open or final open state. 
     In this open or primary open or final open state, the first panel is placed in a position at least approximately facing the first opening  4 , the first flange  5 , and the first panel  6   v  when it is in the closed state, this position being at least approximately orthogonal to the axis AA of the entrance/exit space  13   a , while the separation space  12  is located beyond the distal end boundary  13   b  of the entrance/exit space  13   a.    
     In this embodiment, the carrying means  11   a  and the movement actuation means  11   b  of the first door  6  comprise at least one actuator  20  placed along an axis that is at least approximately orthogonal to the first opening  4 , the first flange  5 , and the first panel  6   v  when it is in the closed state and ensuring the initial translational movement and the subsequent translational movement. 
     The course of translational movement is that necessary to make the separation space  12 . 
     In the embodiment shown, the outside surface  6   a  of the first panel  6   v  in its open or primary open or final open state is turned toward and removed from the first opening  4 , the first flange  5 , and the first panel  6   v  when it is in the closed state. Thus, the inside surface  10   b  of the second panel  10   v  in its open or primary open or final open state is turned toward and also removed from the first opening  4 , the first flange  5 , and the first panel  6   v  when it is in the closed state. 
     In the embodiment shown, the first panel  6   v  of the first door  6  is laterally extended by a mechanism plate  15 , which is supported at least approximately orthogonally at the end of the actuator  20 . Preferentially, two diametrically opposite mechanism plates  15  and two actuators  20  are provided. 
     Reference is now made more particularly to  FIGS. 17 to 21  that illustrate a third variant embodiment of the chamber  1 . 
     In this case, the carrying means  11   a  and the movement actuation means  11   b  of the first door  6  are arranged to be able to move the first panel  6   v  from its closed state in a rotational movement around an axis that is at least approximately parallel to the first opening  4 , the first flange  5 , and the first panel  6   v  when it is in the closed state, and this so as to separate the first panel  6   v  from the first flange and then to bring the first panel  6   v  into its position in the open or primary open or final open state. 
     In this open or primary open or final open state, the first panel is placed in a lateral position in relation to the first opening  4 , the first flange  5 , and the first panel  6   v  when it is in the closed state, this position being at least approximately orthogonal to the axis AA of the entrance/exit space  13   a , while the separation space  12  is located beyond the lateral boundary  13   c  of the entrance/exit space  13   a.    
     In this embodiment, the carrying means  11   a  and the movement actuation means  11   b  of the first door  6  comprise at least one system of rotational movement  21  along an axis  21   a  that is at least approximately parallel to the first opening  4 , the first flange  5 , and the first panel  6   v  when it is in the closed state and ensuring both the initial movement and the subsequent rotational movement. 
     The system of rotational movement  21  comprises a hinge with an axis  21   a  and a means for driving in rotation around the axis  21   a.    
     The course of rotational movement is close to that of a half-turn. 
     In the embodiment shown, the outside surface  6   a  of the first panel  6   v  in its open or primary open or final open state is turned opposite the inside surface  3   b  of the first wall  3  of the first chamber  1 . Thus, the inside surface  10   b  of the second panel  10   v  in its open or primary open or final open state is turned toward and located in the proximity, particularly in the immediate proximity, of the inside surface  3   b  of the first wall  3  of the first chamber  1 . 
     In the embodiment shown, the first panel  6   v  of the first door  6  is laterally extended by a mechanism plate  15 , which is supported by the articulation of the system of rotational movement  21 . 
     With a mechanism plate  15  of sufficient length, it is possible to make a separation space  12  of sufficiently large size, as indicated. 
     Reference is now made more particularly to  FIGS. 22 and 23  that illustrate a fourth variant embodiment of the chamber  1 . 
     In this case, the carrying means  11   a  and the movement actuation means  11   b  of the first door  6  are arranged to be able to move the panel from its closed state in a movement comprising a translational movement along a curvilinear axis  22  corresponding at least approximately to an arc with an axis  23  that is at least approximately parallel to the first opening  4 , the first flange  5 , and the first panel  6   v  when it is in the closed state. 
     In this embodiment, the carrying means  11   a  and the movement actuation means  11   b  of the first door  6  comprise at least one deformable parallelogram system  24  along an axis  23  that is laterally offset in relation to the first opening  4 , the first flange  5 , and the first panel  6   v  when it is in the closed state. 
     For example, the course of rotational movement of the deformable parallelogram  24  is on the order of a half-turn. 
     In the embodiment shown, the outside surface  6   a  of the first panel  6   v  in its open or primary open or final open state is turned toward the inside surface  3   b  of the first wall  3  of the first chamber  1 . Thus, the inside surface  10   b  of the second panel  10   v  in its open or primary open or final open state is turned toward and located in the proximity, particularly in the immediate proximity, of the inside surface  3   b  of the first wall  3  of the first chamber  1 . 
     With an axis  23  that is sufficiently offset laterally in relation to the first opening  4 , the first flange  5 , and the first panel  6   v  when it is in the closed state, it is possible to make a separation space  12  of sufficiently large size, as indicated.