Sutures knotting and calcifying. Cartilaginous membranes ossifying. Mineral deposits of stonelike hardness forming in the gall bladder, liver, the major arteries. Nails thickening, skin going scaly, hair thinning, graying, going all brittle. Nipples darkening, breasts sagging, ducts shrinking, glands puckering. The urogenital system, evolution’s canny trade-off of fertility for mortality, permanently bewildered. Deposits of rich bloody marrow dying out in their bony nooks and crannies, replaced by thick yellow pockets of inert fat. Loss of acuity in the retinas and in the weirdly complex machineries of the inner ear. The ancient gland that was the brain, tirelessly shifting its hormonal sediments until its reptilian backwaters filled with toxic deposits as tough to clean out as a childhood neurosis.