The end result of all this tended to be nonviable populations clearly identifiable as inbred. So, as often as Isolation, Caricaturization, and Enhancement had taken root and run their courses, they had led either to extinction of colonies or to an ameliorative process called Cosmopolitanization, wherein formerly isolated groups had remerged with their long-lost cousins of the same race and bred back in the direction of healthy and sustainable hybridized strains.