Open Access Publishing and Citation Archives: Background and Controversy
Released: 2006-12-12T00:00:00

Introduction

This report begins with an inventory of basic information: definitions and guides to histories of the growth of open access publishing and citation archives and descriptions of selected major open access activities. It moves on to summarize major points of difference between proponents and opponents of nongovernmental open access publishing and databases, and then highlights federal, including National Institutes of Health (NIH), open access activities and contentious issues surrounding these developments. The report also briefly describes open access developments in the United Kingdom (where a number of governmental and nongovernmental initiatives have occurred) and in the international arena. Finally, controversial issues which could receive attention the 110 th Congress are summarized.

Definitions of Open Access Publishing and Database Models

The "open access movement" is said to have begun in 1966. The term describes a variety of activities that includes access to archives of indexed citations of articles, access to separate journal articles that were published in traditional, subscriber-pays journals, and access to free, online journals. According to a May 23, 2005 Wall Street Journal article,"[c]urrently, the open-access movement makes up between 1% and 2% of the market, experts say. While that number seems small, the concept is assuming an important role channeling academic discontent" about the rising costs of journals.

In traditional, subscriber-pays publishing , the publisher, who holds the copyright to an article, pays most printing and distribution costs and, in order to read an article, the journal subscriber pays fees, whether for hard-copy or online versions. Sometimes an author is required to pay printing page charges for complex graphics or color presentations.

" Open access " publishing generally means that the author or publisher, who holds the copyright to an article, grants all users unlimited, free access to, and license to copy and distribute, a work published in an open access journal (which may be published initially electronically or in hard-copy). Users can also make copies for their personal use, if authorship is properly attributed. Open access publishing often requires an author to pay for publishing or posting of a paper. Estimates of fees charged vary, but generally range from about $500 to $4,000. These charges may be paid by individual authors, or by institutions, pursuant to institutional subscription contracts with open access journals that cover publication charges for all authors affiliated with that institution. Typically, open access publishers require that a complete version of the work and related materials be deposited electronically in an online database that permits open access, distribution, interoperability (allowing users to extract and use the data in other research), and long-term archiving.

In " free access " publishing neither an author nor a reader pays for articles to be published or posted on the Internet, but other open access features may not be mandatory.

A few commercial publishers have adopted some open access features in their business models. However, the fundamental difference is that traditional publishers generally require readers to pay to read or print an article, or to search indexes of abstracts or citations. Open access publishers generally do not require readers to pay for these services. Some traditional publishers say they already provide open access in that they may make papers freely available online—but this is usually a year or two after publication. The publishers still hold copyright, and they may or may not allow the author to post his or her published articles in an open access repository or database, or on the author's own website.

The scope of open access repositories or archives varies. Some contain published journal articles or nonpublished "grey literature" in all fields of science or in specific scientific disciplines. Some archive a specific researchers' preprints, articles, or research reports; or, as in the case of the National Institutes of Health model, articles, data, or other materials funded by an agency, but prepared for publication by traditional publishers. Some open access repositories archive only citations for articles or other materials; some archive both citations and full text materials; some allow free downloading and some do not.

Selected Illustrations of Nongovernmental Open Access Activities

A variety of nongovernmental open access publishing activities is illustrated next with summaries of some current major open access information systems or publishers. These are categorized by general type, including commercial open access systems, academic-sponsored systems, and subject or disciplinary systems. NIH's PubMed Central (PMC) system is described in detail in the section of this report that focuses on NIH.

Illustrations of Open Access Systems

Public Library of Science (PLoS)

PLoS is a nonprofit group, spearheaded in large part by Dr. Harold Varmus, former NIH director. It provides readers with free access to peer reviewed articles published in PLoS's electronic journals. The activity is supported by author payments starting at $1,500 per article and multi-million dollar philanthropic foundation contributions. PLoS's journals include PLoS Biology, PLoS Medicine, PLoS Computational Biology, PLoS Genetics, and PLoS Pathogens. PLoS seeks to launch journals in other disciplines. It has the goal of publishing highly selective, top-quality articles competitive with the quality of articles in traditional, subscriber-pays journals like Science and Nature. Different from traditional, subscriber-pays publishing, which requires authors to cede copyright to the publisher, authors who publish in PLoS retain copyright to an article, but are required to deposit a copy of the article in an open access, online repository that allows long-term archiving. Reportedly, one of the group's major goals is to make research more accessible by eliminating publishers as copyright holders and by ending the "balkanization" of scientific information in separate databases. Under PLoS's editorial policy, "any data can be integrated into new work as long as the original author is credited appropriately. The model is inspired by GenBank, the central repository of DNA sequence whose open access policy has driven much of the progress in genomics and biotechnology of the last decade." PLoS has announced that it will assist scientists in developing countries by providing Internet access for readers of limited bandwidth, and will waive or defray author charges for those who cannot afford to pay.

BioMedCentral (BMC)

This is a British-founded, independent, commercial publishing system, which provides free access to peer reviewed biomedical research published online. It publishes its own approximately 120 biomedical journals and says articles are rapidly peer reviewed; peer review policies are determined by each journal's board. Authors retain copyright of their work. BioMedCentral charges authors or their institutions for the costs of peer review and publication. "Other sources of revenue include subscription access to commissioned articles, sales of paper copies of our journals to libraries, sales of reprints, advertising and sponsorship, and ... a range of subscription-based value added services such as literature reviews and evaluation, personalized information services delivered electronically, provision of editorially enhanced databases, tools that help scientists collaborate, and other software research aids." It archives materials in PubMed Central, NIH's free archive of biomedical literature.

Faculty of 1000

BioMedCentral has created a fee-based subscription service called Faculty of 1000. It originated because the publication of so many articles in online journals (sometimes free to readers) with varying degrees of peer review has spawned a new industry: peer reviewers or experts who evaluate articles after publication and provide a selected list of articles recommended for reading to their paid subscribers.

patientINFORM

In spring 2005 patientINFORM was launched by the American Cancer Society, the American Heart Association, and the American Diabetes Association, in partnership with more than 20 publishing firms, to provide immediate access to free, selected full-text research articles and materials from the three organizations' websites, which provide links to different types of published materials. "According to the group, the initiative 'is being driven by recent trends indicating that public awareness of clinical research, heightened by media coverage and fueled by the spread of broadband Internet, has led more and more patients to go online to find the latest information about treatment options.'" NIH's decision to launch its system, reportedly, accelerated the formation of patientINFORM . After a period of evaluation, "... the group will determine whether to expand its focus past the three initial diseases into rarer conditions." This system may not permit permanent access to materials on it, since the organizations maintaining the website may, overtime, replace or remove materials posted.

Illustrations of Academic-Related Systems

Some universities ensure that their scholars' publications are available online in a free open access repository by creating their own archives or participating in networked open access archives. Several examples are outlined next.

EScholarship Program

The EScholarship Program of the University of California system was launched in the fall of 2003. It is an electronic, searchable repository that makes freely available an archive of the publications (and other media) and some research databases of University of California researchers. The vehicle is also used to disseminate the university's own open access, peer reviewed published journals. Supporters of systems like this say that indexing materials improves access to them and, if full text is available, widens reader access, and improves utilization of federally financed research and development.

DSpace

A number of research universities are participating in DSpace , a networked multi-member electronic repository that indexes and shares some research data, articles, and other media. It was developed by the Massachusetts Institute of Technology (MIT) in collaboration with Hewlett-Packard. Some universities, such as Cornell, reportedly, are using it to provide free access to peer reviewed publications.

Highwire Press

This is an archive run by Stanford University that provides online, full-text articles for biomedical and other scientific journals. It adheres to the post-publication timing policies of each journal, with most articles archived and made accessible between 6 and 24 months after publication in the original traditional, subscriber-pays published journal. Some of these articles, but not all, may be viewed for free.

Illustrations of Dedicated Subject or Disciplinary Archives

Some repositories permit free searching for citations, abstracts, articles, or other materials in specific disciplinary fields or areas of application, or by researchers affiliated with specific academic systems, or by other researchers. A few illustrations are given next.

arXIV.org22

Initiated in 1991, this is a free, online archive which allows physical science researchers to make preprints of their papers available before formal publication. Maintained by the Cornell University Library (in cooperation with the National Science Foundation and the Department of Energy), it includes articles in the following subjects: physics, mathematics, nonlinear sciences, computer science, and quantitative biology. According to PLoS , "This server expanded from its initial role as a vehicle for sharing preprints in theoretical high-energy physics to its current role as the principal 'library' for a large fraction of research literature in physics, computer sciences, astronomy, and many mathematical specialities. Today, more than half of all research articles in physics are posted to this server prior to their publication in conventional journals. In many fields, these 'eprints' are the de facto publications of record.

CogPrints

Some types of foreign open access publishing include access to U.S.-generated research findings. CogPrints is a free, British-run, self-archive of full-text, electronically available, published, peer reviewed journal articles as well as preprints of unrefereed articles in the "cognitive sciences, including any area of psychology, neuroscience, and linguistics; many areas of computer science (e.g., artificial intelligence, robotics, vison, learning, speech, neural networks); philosophy (e.g., mind, language, knowledge, science, logic); biology (e.g., ethology, behavioral ecology, sociobiology, behavior genetics, evolutionary theory); medicine (e.g., psychiatry, neurology, human genetics, imaging); anthropology (e.g., primatology, cognitive ethnology, archeology, paleontology), as well as any other portions of the physical, social and mathematical sciences that are pertinent to the study of cognition."

Major Issues Relating to Open Access Publishing

Controversies arise because developments in open access systems and policies seem to have outpaced society's ability to design equitable and efficient mechanisms and economic reward structures to manage transitions between traditional and open access publishing and archiving. There is evidence that greater acceptance of online and open access publishing is "forcing traditional journals to address fundamental financial and philosophical challenges," which has generated heated discussions in the scientific publishing community.

Major arguments made by supporters of open access publishing (largely scientists, librarians, and some non-profit publishers) are that it rides the new wave of inevitable changes in publishing and electronic dissemination of information due to development of the Internet, hastens scientific progress, gives access to more readers, promotes economic development, and, in the case of federally funded research, provides citizens with ready access to the results of research and development that their taxes funded.

Opponents of open access publishing (primarily traditional publishers and major scientific associations) cite such issues as the doubtful permanence of electronic archives, questions of copyright ownership and reductions to traditional publishers' profits, costs to researchers who have to pay to have their manuscripts published in open access journals, the possibly dubious quality of articles published, questions about peer review processing and quality, perceptions of the academic community and the academic reward system which appear to give more status to articles published in traditional, subscriber-pays journals, and so forth. See the Appendix for a list of additional issues raised about the impact of open access publishing on the academic community, scholarship, and teaching.

The following sections elaborate on some of these issues.

Journal Publishing Costs and Sources of Revenue

The costs of publishing a journal article include preparing the manuscript for publication (initial sorting and selection of manuscripts to be refereed, peer review, selection, editing, layout, table of contents, overhead, letters to the editor, etc.) and distribution. According to a Wall Street Journal story, costs for publishing an article typically range from $3,000 to $4,000. However, these costs can average more than $10,000 for some journals, such as Science magazine, which publishes only a small fraction of the articles submitted (about 7%), but has high value-added costs, which include reviewing all articles submitted and selecting those that will be published, layout, graphics, distribution, and so forth. Another author has estimated costs for publishing an article in other journals: BioScience , about $7,000 per article; Nature and New England Journal of Medicine, in excess of $1,500.

The comparative costs of publishing online only versus traditional journals that print hard-copy are uncertain. While some observers say that article processing costs are similar for print and electronic publications, other research shows that electronic publishing and distribution are cheaper than hard-copy publishing. A private British funding group reported that research it commissioned showed that author pays, open access publishing models are a viable alternative to subscription journals and "have the potential to serve the scientific community successfully." Specifically, "Open access publishing should be able to deliver high-quality, peer-reviewed research at a cost that is significantly less than the traditional model while bringing with it a number of additional benefits."

Who Pays?: Traditional, Subscriber-Pays Journals

Traditional publishers usually incur most of the costs of publishing an article. Revenue comes from subscriptions, advertising, reprints, and, in some cases, from authors who are asked to subsidize the costs of color printing or printing of complex graphics, or page charges for publishing articles in traditional hard-copy journals. Data for 2004 from a study by the Kaufman-Willis Group, which surveyed sources of revenue for traditional and open access publishers, indicates that the three largest sources of revenue for traditional journal publishers were subscriptions, which provided, on average, about 70% of total revenue; industry support (advertising and sponsorship) at about 15% for some journals and membership dues at about 8% for others; and author fees and charges.

Who Pays?: Open Access Journals

Reportedly, most, but not all, open access journals require authors to pay from about $500 to $4,000 for publishing costs. Open access journals also receive funds from advertising, corporate sponsorships, government grants, the use of volunteers, and foundation grants. The study by the Kaufman-Willis Group, cited above, identified the three largest sources of revenue in 2004 for open access journal publishers as industry support (advertising and sponsorship) at 37%; author fees and charges at 30%; and grants at 13%.

This same study showed that, contrary to expectations, author fees were charged by a larger fraction of traditional, subscriber-pays journals than open-access journals. Author fees include charges for color printing, page layout, page publication charges, and so forth. This finding, in combination with the data on percentage sources of revenue, appears to mean that in relation to the total number of publishers, traditional publishers more than open access publishers charged fees to authors, but the payments (as a percentage of publishers' total revenue) were less to traditional publishers than to open access publishers. The fees traditional, subscriber-pays publishers charged to authors were primarily for small changes, color views, and related items, rather than the larger fees open access journals charge authors to publish in the open access journal.

Policies For Paying Publication Costs in Relation to the Future of Open Access Publishing

Among the issues related to "author pays," and possibly to the future of open access journals, is whether the federal government will continue to allow some research grant funding to be used to pay charges levied on authors or institutions for the costs of publishing articles resulting from federally funded research. This may become a more prominent issue if open access publishing becomes a larger part of the market.

Now, pursuant to OMB's guidelines, federal agencies that award funds for scientific research permit investigators at universities, colleges, and nonprofit institutions to charge the costs of publishing a scientific article as an allowable direct cost (usually paid in full) if the funding agency agrees that they are an appropriate part of the project. If the costs of publishing are disallowed as direct costs, the federal governments likely will pay for these costs as part of "facilities and administrative" (F&A) indirect costs, if the research was federally sponsored and if the journal levies similar charges on all research papers published by the journal. If the cost is covered as an F&A indirect cost, full reimbursement may not occur due to limitations on recoveries of some indirect costs.

Some federal agencies have issued policy guidance about allowing as a direct cost of project support, fees for publication and page charges in order to disseminate reports of the agency's federally funded research results. The National Science Foundation (NSF), for instance, says,

The proposal budget may request funds for the costs of documenting, preparing, publishing or otherwise making available to others the findings and products of the work conducted under the grant. This generally includes the following types of activities: reports, reprints, page charges or other journal costs (except costs for prior or early publication); necessary illustrations; clean up, documentation, storage and indexing of data and databases; development, documentation and debugging of software; and storage, preservation, documentation, indexing, etc., of physical specimens, collections or fabricated items.

According to NIH, the following publication costs are allowed:

Page charges for publication in professional journals are allowable if the published paper reports work supported by the grant and the charges are levied impartially on all papers published by the journal, whether or not by government-sponsored authors. The cost of reprints and publishing in another media, such as books, monographs and pamphlets, also are allowable. Publications and journal articles produced under an NIH grant-supported project must bear an acknowledgment and disclaimer as appropriate, as provided in Administrative Requirements—Availability of Research Results: Publications, Intellectual Property Rights, and Sharing Research Resources. "

Publication costs, library fees, and journal subscription costs related to a specific research project may be allowed as costs of a federally supported research project. It is not known if the federal government will extend these allowances to include the costs of institutional subscriptions that open access publishers or journals may sell to colleges or universities to cover publication fees for all authors affiliated with a specific institution. At least one report cautions that some federal agencies may not allow publication costs to be covered. Harold Varmus, a co-founder of PLoS, considers "publishing fees as the final, relatively cheap step of a research project" and contends that the federal government should pay for these costs.

In 2003, the UK Wellcome Trust, a large research charity that supports biomedical research in the United Kingdom, announced its support of online open access journals and said it would allow scientists it funds to use a portion of their grant to pay author charges required by the journals. The U.S.-based Howard Hughes Medical Institute allows grantees to use up to an additional $3,000 to spend for publishing in open access journals.

Some professional groups have developed, or widened, policies for "author pays" publishing allowing free access to readers. For example, in 2006 the American Chemical Society and Elsevier, both of which publish large numbers of scholarly scientific journals, announced that they would establish mechanisms permitting authors to pay a few thousand dollars to allow their articles to be viewed online for free after publication of the journal. Similarly, anticipating a the release of many important papers after the 2007 start-up of the Large Hadron Collider (LHC), particle physicists are seeking free access to all articles published in their field. In a report released in June 2006 a task force, led by CERN, a physics laboratory in Switzerland, proposed "that a consortium of labs and funding agencies pay publication costs for particle physics papers. It would cost $6 million or more a year to include all the journals willing to offer an open-access option, the group estimated. That would cover up to half of the 6,000 or so original theory and experimental papers published each year."

Supporters of open access sometimes contend that now most publishing costs are borne by research sponsors, such as the federal government, and that allowing these sponsors to shift support to pay for open access publishing will not cost more and will provide more benefits to society. For instance,

Asking research sponsors to pay for publication of the research they support may seem to impose new financial burdens on the government agencies, foundations, universities and companies that sponsor research. But these organizations already pay most of the costs of scientific publishing—a huge fraction of the US $9 billion annual revenue of scientific, medical, and technology journals comes from subscriptions, site licenses, and publication fees ultimately billed to grants or employers. Much of the rest is borne by society in the form of increments to university tuitions; healthcare costs, including drug prices; and state and federal taxes that subsidize healthcare, libraries, and education. Surely the cost of open-access digital publishing cannot, in total, be more than we are already paying under the subscription and licensing model. By simply changing the way we support the scientific publishing enterprise, the scientific community and public would preserve everything we value in scientific publishing and gain all of the benefits of open access.

In opposition, some say if the government paid such costs, money would be diverted inappropriately from research to publishing. Some universities say their costs will increase if they need to reimburse researchers to pay author fees for open access journals and if they still have to pay high costs for subscriptions to traditional journals. In addition, some young scientists/investigators say that business models that force authors to pay for publication in open access journals could hurt them since they often have smaller grants and "... an author-pays model could amount to a 'tax for productivity.' " Another issue is that in some applications-oriented fields, such as medicine, engineering, computer science, management, and pharmacy, users of journals, including open access materials, are often private sector parties who read the journals, but likely would not be authors who would contribute to journal publication costs. As a result, researchers who produce knowledge would bear disproportionate costs for journal publication.

Rising Subscription Costs

It has been reported that traditional, subscriber-pays academic publishing has a $5 billion global market, and that one of the leading publishers, Reed Elsevier journals, "bring[s] in about $1.6 billion in annual revenue with an operating-profit margin of about 30%." This profit, according to the same source, could be cut to between 10% to 15% if open access publishing were expanded. (The total scientific and technical journal market has been estimated at $9 billion.)

Subscription costs vary depending upon the journal and how many journals an institution subscribes to. Prices also vary for individual versus institutional subscriptions. According to one article, in October 2003 two scientists at the University of California at San Francisco were charged $91,000 "from Elsevier's Cell Press unit for one-year's access to six biology journals." The University of California in 2003 was reportedly charged $7.7 million a year for subscriptions to 1,200 Elsevier periodicals, which was a 25% price reduction from the original bill, negotiated after faculty moves to boycott Elsevier journals if the original bill price were not reduced. Reportedly, sometimes sales are increased by publishers forcing libraries to subscribe to more than they want because publishers often "... bundl[e] ... journal subscriptions into large contracts often not well matched with institutional research interests." This includes bundling together journals that are made available electronically in database systems that access current and archived journals. Bundling of this sort can force libraries to pay for access to the same journal several times if it is included in more than one database to which the library subscribes.

Rising journal subscription costs, it is argued, are too expensive, making it difficult for libraries, especially university libraries and the public to afford many journals, and forcing them to sacrifice spending on other media. Reportedly, Rick Johnson, former Director of the Scholarly Publishing and Academic Resources Coalition (SPARC), said that because of rising costs, library spending on print media is shifting from monograph and other materials to support largely journal subscriptions, with price per journal reportedly having doubled within 15 years. He illustrated this by saying that while the Consumer Price Index increased 64 percent, libraries are paying 227 percent more for journal subscriptions. According to a National Library of Medicine (NLM) report, Access to Biomedical Research Information, prepared for Congress in June 2004, "prices of commercial biomedical titles increased 224% from 1988 to 1998, while the prices of nonprofit titles increased 129%." The NLM report was quoted as saying that "'These trends have adversely affected the ability (from a cost standpoint) of academic and health science libraries to continue to support the needs of the research and health care provider communities for access to biomedical literature....'"

The current open access movement has been fueled by actions of academics and librarians located at the University of California campuses, as well as at other academic sites, who, in late 2003 and 2004, mounted strenuous objections to increases in costs for subscriptions to scientific journals. Some demanded a 25% reduction in subscription fees from major scientific publishers, with Reed Elsevier often cited as a major target, and said if fees were not reduced, they would relinquish journal editorial board memberships or stop providing free peer reviews for major scientific publishers.

The Role of Foundation Support for Open Access Journals

The question as to whether open access journals can exist without subsidies may still be unanswered. Some observers wonder whether open access journals and archives can be sustained without philanthropic contributions and what will happen if foundation contributions are ever reduced. It has been reported that several journals which attempted to provide free access to readers reversed policies due to falling subscription rates and revenues for print journals. These journals reportedly included the Journal of High Energy Physics, which published online for free for six years; it originally did not charge authors a fee, but ultimately decided "to impose a subscription fee of about $1000 a year" for readers. There is also a question of whether, if publishing patterns and revenue sources change, publishers will obtain enough revenue to be able to risk starting up niche journals in narrow fields of science and which have a small readership, which many traditional publishers have been able to do given their revenue margins.

Publishing Revenues Support Scientific Societies

The point is often made that scientific societies, which may publish on their own or may use commercial publishers to publish their journals, reap considerable profits from their share of journal revenues. They then use these profits to support societies' activities, which can include advocacy and assistance to new researchers in the field. Critics of this practice say that these professional associations need to find different business models, or alternative ways to raise money, to support their activities instead of using publishing profits, which are based on payments from subscribers, university libraries, and, in many cases, indirect costs of federally funded R&D.

On the other hand, revenues to scientific societies may not decrease since, at least according to one professional association, the rise of online publishing does not reduce subscriptions to print journals. For instance, according to the American Physical Society (APS), which receives journal publishing profits, preprints of articles in physics, computer science, and mathematics are published on arXIV.org , an open and publicly accessible archive. The editor-in chief of the American Physical Society, reportedly said that

there has been no decline in the subscriber base of journals in those disciplines. In fact the 'contrary is true,' he said. He explained APS journals have a very liberal copyright policy that gives back to the author the right to post articles on e-print servers even before journal publication. They also allow authors to update articles on the servers, using the corrected journal form, after publication....

Commercial and Open Access Publisher Practices

Proponents of open access have alleged that some traditional publishers' practices limit equitable access to scientific information. These practices include "restrictive licensing terms overriding copyright and fair use practices, [controls on] long-term archival access to electronic content, and ... selective deletions of published articles from database and e-publications." Traditional, subscriber-pays publishers often disagree and say that they are beginning to adopt some features of open access publishing, including, but not limited to, developing multimedia enhancements, allowing authors to self-archive their articles, and improved content search capabilities.

Journal Enhancements

Some traditional publishers (like many open access publishers) have taken steps to enhance the content of journal articles they post online by permitting digital access, permitting access to ancillary databases and related materials, or allowing posting of preprints in author's websites or institutional repositories. However, often traditional, subscriber-pays publishers charge a fee to view the journal article or enhancements, "... with fees ranging from a few dollars to a few tens of dollars." Open access proponents say that fees should not be charged for access to these kinds of information.

Timing of Free Access to Journal Articles

Subscriber-pays, traditional publishers have a wide variety of policies regarding free access to the articles they publish. The British Medical Journal (BMJ) , for instance, allows free access to all readers for all materials in its journal for one week after publication. After that, non-subscribers have free online access only to original research articles that were published in the hard-copy journal. Only paying subscribers can access editorials and news articles published in the journals and articles that are published only in an online version. After a year access is free to all BMJ materials. Generally, traditional publishers may permit free access to journal articles anywhere from a few months to two years after publication. Proponents of open access have argued that the public or other researchers should not have to wait a year or more to have access to research findings, especially for biomedical research findings, that could be used to improve a patient's health outcome. Another view is that "... limited access to the full text of research articles is bad for science. Such restrictions make it difficult for researchers to build on the entirety of what has gone before and for readers to check whether they have done so. The practice might contribute to citation bias since authors will only reference journals they can access." Still others may find that traditional publishers do not allow electronic access to data in a form that other researchers can easily use to verify findings or to compare in other research projects.

Self-Archiving

Open access publishers require or allow authors to self-archive their articles immediately and to make them accessible for free. Some traditional, subscriber-pays publishers now allow authors to self-archive on the author's own website an electronic version of the preprint of their article, or, after a delay, the published journal article. There are a variety of models for this, sometimes with fees charged. Some traditional publishers allow authors to self-archive the preprint and then link to the printed version after publication (American Meteorological Association); some do not allow posting of the article until a year or more after publication in the journal (American Association for the Advancement of Science); some allow posting of an author's article only on an institutional or educational server, not the author's personal self-archive, (American Anthropological Association); and so forth. The policies of hundreds of U.S. and foreign journals, associations, and publishers are summarized in an inventory, published by SHERPA, a British open access project.

Critics say that archiving only on the author's website makes it hard to find sets of related articles in particular subjects because articles are more accessible when placed in freely searchable repositories that archive articles in many fields by many authors and which can be searched by index or keyword terms.

Commercial and Open Access Search Engines

Some commercial publishers make available free search engines that allow readers to search for citations or abstracts in specific fields or types of information. Some of these repositories link to a text version which can be viewed for free. However, most full text articles found through these searches are not accessible for free; costs to read or download an article average $30 per article, which users or libraries are required to pay. An example is Scirus, a search engine limited to science literature managed by Elsevier , which provides access to short abstracts or excerpts. Open access bibliographic or citation archives have a wide range of policies regarding access to scientific articles. Open access bibliographic archives generally provide free access to abstracts or citations in multiple fields, and often to full-text manuscripts or articles.

NIH's PubMed/MEDLINE is a free bibliographic database that the public can use to search for journal articles. It gives access to references from millions of articles published in almost 5,000 biomedical journals dating back to the 1950s. It gives a citation and abstract and links to full-text articles that are available for free (via publishers' websites or on PubMed Central ) as well as to full-text articles on the publishers' websites that users may have to pay to view. NIH's PubMed Central (PMC) includes the full-text version of almost all articles cited in its database (usually from open access publishers) and in limited cases has links to the full-text versions on publishers' websites. Many journals routinely deposit material in PMC and generally all their published articles are made available for free. PMC also is the repository for articles resulting from NIH-funded research that are submitted under the agency's Public Access Policy. These articles comprise only a small part of the PMC database and many NIH-funded researchers publish the results of their research in journals that do not contribute article to PMC . ( PMC is discussed in greater detail below in the section on NIH's Public Access Policy.)

Open access proponents say that there are multiple benefits to providing free access to articles in online repositories of collections of articles since a reader could identify many related papers on one topic and would bypass the need to search individual authors' websites or to use commercial indexing databases that typically charge a fee to read an article.

Copyright Issues

Supporters of traditional, subscriber-pays publishing argue that publishers, as copyright holders, need copyright protection in order to market journals and sell reprints which support the costs of publishing and archiving both hard-copy and electronic materials. Some also say that copyright ownership is required to guarantee a researcher's accuracy and the authenticity of authorship of an article. In open access publishing, the author of the article retains copyright ownership, but access to the article normally remains free to readers. As will be discussed below, a mixed model is used in the case of NIH's Public Access Policy , which asks authors to voluntarily submit to PubMed Central (PMC) the peer reviewed version of a manuscript accepted for publication in a journal. This should be done as soon as possible, but within 12 months of acceptance of the article by the publisher. Free access to the manuscript is prohibited until after journal publication or for the embargo period specified by the publisher. Publishers, who hold the copyright to articles that are not published using the open access model, retain the exclusive right to disseminate the work for the time before free access is permitted on PMC, but authors are encouraged to conclude agreements with publishers that allow them to place the manuscript in the database. According to NIH, regardless of the publisher's decision, the agency has the right to utilize the journal article under the government purpose license doctrine (even though NIH says it is not exercising this authority). In the future, other agencies may seek to implement public access policies similar to NIH's, but may modify it to use government purpose licensing provisions, which may be controversial. (See the section on NIH, below, for more details.)

Economic Development

Open access publishing, according to many proponents, helps promote economic, social, and technical development and equitable access to scientific knowledge by researchers in countries unable to afford the costs of scientific journals by hard-copy or subscription web access. Many open access systems also say that they will waive publication charges for authors from developing counties who cannot afford to pay to have their articles published.

But some traditional publishers say that scientists in developing countries already have free and ready access to most scientific journals. For example, many traditional publishers "... participate in projects sponsored by the World Health Organization and the Food and Agriculture Organization of the United Nations to provide medical and agricultural journals to readers in developing countries at low or no cost." In addition, more than 2,000 biomedical journals are accessible online to researchers and health workers in developing countries via a philanthropic project called Health InterNework Access to Research Initiative ( HINARI) supported in collaboration with the World Health Organization.

Peer Review and Quality of Articles In Open Access Journals

There is a diversity of views about whether the articles that appear in open access journals have been subject to the same kind of rigorous peer review as those published in traditional, subscriber-pays journals and about whether they are of comparable quality. The peer review process traditionally involves review of quality of the article and selection of articles to be published in a journal. Usually journal editors or editorial boards make an initial selection of articles to be peer reviewed from among those submitted; use a panel of expert scientists who may volunteer their time to review submissions; select articles to be published from among the articles peer reviewers ranked as high quality; and sometimes do some editing.

A long-held principle is that the accumulation of high-quality scientific knowledge rests on a foundation of publication, typically in traditional commercially distributed scientific journals, with the findings and results vetted and validated through a process involving peer review and fee-based journal subscriptions. Critics allege that the open access "author pays" model of paying for publishing costs, including peer review, prevents quality control mechanisms from working correctly and that, in the long run, scientific articles published in open access sources may be less credible than those published in journals which charge subscription fees. A survey published in 2005, funded by traditional, subscriber-pays journal publishers, is reported to have found that the quality of peer review was lower in open access than in traditionally published journals:

Open-access journals ... received fewer submissions and were less selective in choosing among submissions. [It continued] essentially all of the journals reported using editorial review to select and edit submissions. But nearly all of the traditional journals used external peer review, while only editorial staff members reviewed submissions of about 30 percent of the open-access journals.

According to another study, the most rigorous peer review, "as measured by their [journals'] reliance on external reviewers," was largely by traditional publishers, and that, in contrast, "full open access journals tended to depend heavily on editorial staff only for peer review," except for two subsets of open access journals—BioMed Central (BMC) and Internet Scientific Publications (ISP) journals, which had practices more like traditional journals. On the other hand, a study published in 2005 by a publishing analysis firm showed that the quality of nearly 200 open access journals was almost as high in specific medical disciplines as the quality of articles in traditionally published journals.

Some analysts say that peer review in open access journals suffers from the difficulty of finding enough scientist peer reviewers for both the growing number of open access journals and traditional journals. There is also the view that editorial boards of open access journals, may not filter out unacceptable manuscripts as much as traditional, subscriber-pays journal boards do. Thus peer reviewers for open access journals, who interact and report primarily electronically, may be overwhelmed by the number of articles they are given to review, and, ultimately, there may be delay in the system. Publication in peer reviewed journals figures prominently in promotion and tenure processes in academia. Some observers contend that members of the academic and scientific communities may not view publication on the Internet or in an open access journal to be as prestigious as publication in a traditional, subscriber-pays peer reviewed journal.

Others use citation data as a surrogate measure for quality. Some analysts cite data showing that articles posted in open access journals or freely available on the Internet are used and cited more frequently than those published in traditional journals and are, therefore, a better model to ensure the speedy utilization of scientific research. For instance,

Experience in physics where researchers publish in traditional journals and then self-archive their papers in a free database is conducive to scientific communication and favorable to authors because "papers listed in free archives often get more citations...." A recent study showed that in four disciplines, philosophy, political science, electrical and electronic engineering, and mathematics, articles that are freely available via open access publishing have a greater research impact than those not available via open access. Impact is measured by citations made by other researchers to the literature in the ISI Web of Science database. In computer sciences, "a 2001 study in Nature, showed that, at least in one set of disciplines, papers that appear free online are more likely to be cited by other researchers than those that do not. A scientist at NEC Research Institute analyzed nearly 120,000 papers in computer science and related titles. Those that were freely available online had been cited more often in other papers than were those not online, he found. The average number of citations of offline papers was 2.74, compared with 7.03 for those freely available online." A study published in an open access journal, suggested that articles published online in open access journal got cited more often than those cited in subscriber or pay for view journals. The articles examined were published in the Proceedings of the National Academy of Science s in 2004; authors paid $1000 to allow their papers to be read immediately and without cost.

One implication of these data should be noted. Ease of access to articles readily available online, as opposed to those that may be accessible only in hard-copy journals, may increase the propensity to cite them. Thus citation data may not so much measure quality as accessibility.

"Enhanced Public Access Policy": National Institutes of Health (NIH) and Other Agencies

On June 26, 2003, Representative Martin O. Sabo introduced the "Public Access to Science Act" ( H.R. 2613 , 108 th Congress), which would have denied copyright protection to publications resulting from federally funded basic scientific research in order to encourage free dissemination of research results to the public. No action was taken on this bill.

Legislative Origins of NIH Policy

Subsequently, the House Appropriations Committee's report on the FY2005 Labor/HHS bill, H.R. 5006 , July 14, 2004, contained language that led to the NIH's "Enhanced Public Access Policy" ( H.Rept. 108-636 , p. 104). The language, reported to have been authored by Representative Ernest J. Istook, Jr., "recommended" that NIH permit open access to NIH-funded research by "requiring" researchers to deposit peer reviewed articles accepted for publication and associated supplemental materials in NIH's PubMed Central , an free access repository information system, within six months after publication of the article in a scientific journal. If NIH awarded funds for publishing, the research would be made available immediately upon publication. It also instructed NIH to draft a report by December 1, 2004 on how it would implement this policy. Reportedly "librarians and the Scholarly Publishing and Academic Resources Coalition, or SPARC," lobbied "the Appropriations Committee behind the scenes to include the open-access language in the committee's report...."

The conference report on the FY2005 Consolidated Appropriations Act, P.L. 108-447 ( H.Rept. 108-792 , p. 1177), which included funds for Labor/HHS, directed NIH to consider input from publishers as it developed its public access policy, directed NIH to continue to work with publishers to insure the integrity of the peer review system, and requested that NIH "... provide the estimated costs of implementing this policy each year in its annual budget justification ..." in response to concerns from publishers that NIH's database cannot easily handle the new articles it will be required to archive.

NIH's Public Access Policy and NIH's PubMed Central (PMC) Database System

NIH maintains a database, called PubMed Central (PMC) . This is an electronic system that was launched in 2000 and which contains bibliographic citations and the full text of some several thousand peer-reviewed articles that were published in journals in the fields of biomedical, behavioral, and clinical research. The goal of the database system is to develop a publicly accessible, permanent, and searchable electronic archive of life science literature, that is separate from publishers' individual databases Some of the journals participating in PMC (typically open access publishing journals) make full text articles available to users immediately upon publication; some require waiting periods of up to three years to obtain free access to full text of an article. Some journals which participate allow the publication of bibliographic information about an article, but require the reader to link to the journal's website to view the abstract or full article, which may be accessible only to subscribers or for a fee. Many major biomedical journals do not participate in submitting materials to PMC , including such journals as the Journal of the American Medical Association , the American Psychologist , the Journal of Abnormal Psychology , and the New England Journal of Medicine . Electronic access to articles in these journals is usually available for a fee—sometimes over $25 per article—at the journal's website. Publishers may make the text of articles published in some of these journals available to readers for free, but usually only on a delayed basis averaging about 12 months after publication in the journal.

In response to congressional mandate, NIH's policy to archive published articles that resulted from its funding was released for public review and comment in September 2004. After holding several meetings with stakeholders and considering numerous comments from traditional publishers and others submitted during the public comment period, Washington Fax, November 22, 2004; Jocelyn Kaiser, "NIH Unveils Public Access Policy," Science, February 3, 2005; Andrew J. Hawkins, "NIH Says Public Access Policy will Change How Science Is Understood," Washington Fax, May 2, 2005. NIH issued the final policy, which was published in the Federal Register on February 3, 2005. Implementation of the policy started on May 2, 2005.

It asks authors funded by NIH to voluntarily submit as soon as possible to NIH for inclusion in the NIH PMC system, manuscripts that have been edited through the peer review process and accepted for journal publication. Such manuscripts are to be submitted as soon as possible, but within 12 months after acceptance of the article by a scientific journal (instead of six months as originally proposed). They are supposed to be posted and made available for public viewing after the embargo period, or sooner if the publisher agrees, but within 12 months. According to NIH, the requirement is not mandatory and no penalties would be imposed if an author did not submit a manuscript to the free archive. Thus, NIH-funded scientists are asked to

...submit an electronic version of the author's final manuscript, upon acceptance for publication, resulting from research supported in whole or in part by NIH. The author's final manuscript is defined as the final version accepted for journal publication, and includes all modifications from the publishing peer review process. The policy gives authors the flexibility to designate a specific time frame for public release—ranging from immediate public access after final publication to a 12 month delay—when they submit their manuscripts to NIH. Authors are strongly encouraged to exercise their right to specify that their articles will be publicly available through PubMed Central (PMC) as soon as possible.

The version required to be submitted voluntarily is not the final version of the article as copyedited and printed in the journal. Since publishers use different formats for publishing materials electronically, NIH is using a standardized format to archive and make accessible the submitted manuscript in PMC . NIH's policy says that it would accommodate any changes made to the manuscript by the publisher if submitted to PMC and that manuscripts would not be made available from PMC until after the article was published in a journal. PMC will provide a link to the publisher's website (which could possibly charge a fee for viewing) to enable the public to read the article as published in a journal. Specifically,

... under the Policy, the final manuscript will not be made available to the public through PMC until after the copyedited version is published by the journal. Corrections and other necessary revisions of author's final manuscripts will be accommodated. Furthermore, when publicly available, the published article on the journal-sponsored website and the author's final manuscript in PMC will be appropriately linked through PubMed. Corrections and post-publication comments referring to a publication are currently identified and linked in PubMed, and this capability will be linked to the corresponding manuscript in PMC. If publishers wish to provide PMC with the publisher's final version, this version will supersede the author's final manuscript in PMC.

NIH allows researcher/authors to use the submission of the manuscript to meet certain NIH grant reporting requirements. According to NIH, its policy is compatible with existing publishing models. The agency said it,

examined the access policies of the top 20 journals based on citation impact for medicine and medical research and of the 50 journals published by members of FASEB [Federation of American Societies for Experimental Biology]. As of October 2004, 80% of the 20 high impact journals allow public access of some sort through HighWire press within 12 months of publication; of the 50 FASEB journals, 78% offer public access within 12 months."

NIH Director Zerhouni justified the new policy by explaining that it provides electronic access to NIH-funded research, permits formation of a central archive of NIH-funded research publications, advances science by creating an information resource that scientists can mine, and helps NIH "better manage its entire research investment."

NIH has also created a Public Access Advisory Working Group of the National Library of Medicine (NLM) Board of Regents, composed of stakeholders to advise NIH and NLM on policy implementation and evaluation. Modifications are to be made to the system as it becomes operational and is studied by the group. The NIH Public Access Advisory Group met on November 15, 2005. Among its recommendations was that the NIH policy, which is now voluntary, be made mandatory; that manuscripts be posted within six months, instead of the current 12 months; and that the final copyedited version be posted, instead of the author's final manuscript.

In November 2005, in response to several publishers' concerns, NIH revised the existing public access policy to allow publishers, in addition to authors, to request that articles which infringe copyright be removed from PubMed Central , even though the author has the copyright agreement with a publisher, and the public access policy agreement is between an author and NIH. Such infringement might occur if a publisher has not granted permission for an article to be displayed in PMC before 12 months has elapsed or if the author provided NIH with a final copyedited version of the article, which a publisher might oppose.

According to minutes of the Public Access Advisory Working Group's April 10, 2006 meeting,

the majority of members confirmed the opinions expressed at the previous (November 15, 2005) meeting of the working group: (1) the policy should be mandatory; (2) submission should occur within six months (with flexibility to 12 months in the case of journals that publish quarterly or less frequently); and (3) the final manuscripts as published should be the favored form. A minority favors a 12 month submission deadline and submission of the author's final manuscript rather than the final published form.

As announced on September 1, 2006, NIH released a press release describing a modification to the existing implementation process for its open access policy. The policy says essentially that an author does not have to directly submit a manuscript to PMC if he or she publishes in a journal which automatically deposits all of its content on PMC and makes its contents available to the public (which is most of the journals that partner with PMC ). "All but a handful" of Public Med Central journals permit free access usually immediately to the final version of an article and authors who publish with them do not have to take further steps to satisfy NIH public access policy. Seven of the almost 300 journals accessible via PMC require the author to submit manuscripts.

At this time, NIH also initiated a new system called the PubMed Central (NIH Portfolio) project—only for NIH-funded research—which is apparently designed to satisfy NIH needs and the demands of some nonprofit publishers. Although a signed agreement is not necessary, some publishers have signed an agreement for participation with NIH. According to one publisher, it stipulates that published journal articles resulting from NIH-funded research be made available only for internal use in an NIH-funded archive during the embargo period, that the embargo period last no longer than 12 months, and that following the embargo period NIH could provide links to the journal and could also distribute the article directly through PMC . If a journal does submit articles via the bulk system, authors have to confirm the version that is posted on PMC. So far only one journal, Blood , has agreed to participate, but negotiations are underway with other publishers. Authors that publish in any other journal not considered a regular PMC journal or NIH portfolio journal (identified by NIH, for example, as Elsevier journals) need to continue to submit manuscripts to comply with NIH's policy to submit final manuscripts to PMC . These changes occurred after several months of discussions intended in part to allay criticisms (dealing primarily with abridging a publisher's embargo periods before submitting a final journal article, increasing compliance by NIH-funded researchers, and averting additional action to mandate compliance).

Legislative Action in the 109th Congress

On June 21, 2005, the House Appropriations Committee approved H.Rept. 109-143 on the FY2006 appropriations bill that included appropriations for NIH ( H.R. 3010 ). The House bill was passed on June 24, 2005. The report endorsed NIH's objectives in establishing the "Public Access Policy" and included language requiring NIH to develop an "aggressive" outreach program to ensure full participation by grantees in volunteering to submit their journal manuscripts to the NIH archive. It also requested the NIH Director to report to Congress by March 1, 2006 on the number of "articles" deposited and the length of the embargo by publishers—that is, the delay between submission of each peer reviewed "article" to NIH and its subsequent posting on the PubMed Central website—and to estimate the total number of articles available for deposit. S.Rept. 109-103 on this bill endorsed the objectives of the policy but also emphasized the need for interaction between NIH and stakeholders. It urged NIH to work with stakeholders as it implements the new policy; and asked NIH to report by February 1, 2006 on the number of peer reviewed "articles" deposited in the database, on "the extent to which the implemented policy has led to improved public access," on the impact on the peer review system, and on the cost of operating the database. The bill enacted after conference committee action was sent to the President for signature on December 28, 2005 (signed as P.L. 109-149 ). The NIH report to the committees was released in January 2006. It reported that for the first eight months of the system, the rate of submission was low, less than 4% of the total number of articles estimated to be eligible for submission, that is 1,636 out of about 43,000 that could be deposited. Lack of awareness, it reported, does not appear to be the primary reason for the low submission rate. The report did not describe the reasons for the low rate of participation, but publisher resistance seems apparent. The NIH said it will continue to work with participants and stakeholders to improve public access. It also identified three issues the working group was continuing to examine, which undoubtedly contribute the low participation rates:

Should investigators' participation in the Policy be mandatory or voluntary? Which version of an article should be deposited in PMC: the author's final peer reviewed manuscript, or the final, edited article as it is published in the journal? What should be the length of the embargo period before public access to an article is permitted through PMC?

In 2006, the House Appropriations Subcommittee on Labor, Health and Human Services, and Education again addressed the issue of NIH's public access policy. Testimony on the issue was delivered at an April 6, 2006 subcommittee hearing. The full Appropriations Committee reported an original bill, H.R. 5647 on June 20, 2006. Sec. 220 would change NIH's policy to make it mandatory that all NIH-funded researchers submit electronic versions of final, peer-reviewed manuscripts to PubMed Central within one year of acceptance for publication in a journal. No further action has occurred. The Senate bill, S. 3708 , does not contain this language. Both committee reports on the bills contain language which commends the PMC repository and observe that NIH is continuing to work with researchers, publishers, societies and other stakeholder to improve public access.

The American Center for Cures Act, S. 2104 , was introduced on December 14, 2005, by principal sponsors, Senators Joe Lieberman and Thad Cochran; it contains a provision on translational research, including a section requiring NIH grantees to provide NIH with a final version of all peer-reviewed manuscripts accepted for publication within six months from date of publication. According to the American Psychological Association, a Member of Congress had planned to, but did not finally, introduce an amendment during committee consideration of H.R. 6164 , the NIH Reauthorization Act, "that would have required all journal articles about federally funded research to be deposited in a free, open archive (NIH's Pub Med) no later than six months after they were accepted for publication." The bill was reported out of the authorizing committee, the House Committee on Energy and Commerce, and approved in the House on September 26, 2006. According to the report, "The Committee has listened to stakeholder concerns about NIH's current open access policy with respect to making published literature available online. The Committee will continue to monitor the open access policies adopted by the NIH, including the management of the program and the participation levels of scientific journals" ( H.Rept. 109-687 , pp. 22-23). The Senate passed H.R. 6164 , amended, without written report on December 8, 2006; the House agreed to the amended bill on December 9; and the bill was sent to the President on December 9.

Reportedly, some Members of Congress have supported the position of major opponents of the NIH public access policy. Senators Larry Craig, Mike Crapo, and Kit Bond, according to a news article, sent a letter to NIH Director Zerhouni on November 18, 2005, which supported the FASEB group position of having NIH post abstracts which are linked to publishers' websites to read the full text of articles. The Senators also questioned NIH's ability to fund the public access system due to limited resources and requested that NIH meet with representatives of the group to consider their proposal. Dr. Zerhouni reportedly said he would welcome a meeting.

Criticisms of "NIH's Enhanced Public Access Policy"

Criticisms of the NIH policy have come from traditional, subscriber-pays publishers as well as proponents of open access.

For instance, PLoS 's supporters have criticized the NIH policy for its voluntary compliance requirement and said "... the agency's language should have been to 'require' or 'expect' rather than 'request' the deposition of NIH-funded articles in the National Library of Medicine's free-to-use Internet repository, PubMed Central." In addition, according to PLoS "... the maximum allowable delay before articles' public release should have been at most 6, rather than 12 months—particularly since no publisher has presented evidence that the free availability of a fraction of its journals' articles half a year after publication would adversely affect subscription revenues." Others say that the 12-month delay for public access falls short of achieving goals of congressional intent and is too lengthy "in a field as dynamic as biomedicine," where patients need immediate access.

NIH policy has also been criticized by some who say that NIH should utilize free access policies that exist in the not-for-profit publishing community, which, they say, are more cost-effective. They suggest that instead of putting articles in PMC , NIH should create a search engine that has the capability to crawl the full texts of existing journals, including nonprofit journals, to allow access to articles on the original journal's website and to provide access to other articles on the topic. Publishers often charge a fee to access articles this way. Among the groups who have commented on this position is the Washington DC Principles for Free Access to Science and the American Physiological Society.

By way of example, Google Scholar , which was launched in 2004, is a free Internet search engine that allows readers to search for peer reviewed articles, preprints, abstracts, grey unpublished literature and other scholarly analyses. If it links to a full-text article, the article is likely to have been published at least a year before the date of the search. There is no assurance that the search engine captures all current or archived materials available in a field. Full text of publisher-controlled, copyrighted materials may be indexed with a citation, but a reader may be linked to the publisher's website to obtain full text of the published version for a fee. In addition, there may be a direct link to the full text of a preprint or a version posted by an author or university archive website.

Some focus on the notion that NIH policy may promote the forfeiture of patent rights. A legal analysis contends that pre-publication "manuscripts placed on the PMC database 'likely' can be considered 'printed publications' for patent purposes, thus 'triggering the one-year time period for filing a U.S. patent application covering research disclosed in the manuscript....' " "Current practice," it is charged, "relies on the date of journal publication to start the clock."

A report prepared for the American Physiological Society criticized the NIH policy as limiting technology development and commercial competition, specifically that "the open access plan 'undermines the principle of [Bayh-Dole] that the private sector is the preferable vehicle to move federally-funded research results to the public and the marketplace.' " It should be noted that the Bayh-Dole law applies to technology transfer, not to publishing of research results.

According to NIH officials, voluntary participation in the public access system has been very limited: only about 4% to 5% of articles by NIH grantees have been submitted, and a survey (by a publisher group) contends that only about 18% of NIH grantees understand how to submit a manuscript for posting in the public access archive. In response, the Federation of American Societies for Experimental Biology (FASEB), which opposes the NIH policy as configured, proposed that the public access policy be modified so that NIH links readers from abstracts of articles to publishers' websites to read an article, rather than to the article itself, and that NIH create an archive of full text of articles for internal NIH use only. NIH officials are reported to have objected to this proposal, saying it would prevent achieving the policy's three core goals: a stable and permanent archive, an archive available to awardees to help communicate research findings, and an archive accessible to the public.

Legislative Proposal to Extend Open Access Policies to Other Agencies: The Federal Research Public Access Act (FPRAA)

S. 2695 , the Federal Research Public Access Act of 2006, was introduced on May 2, 2006, co-sponsored by Senator John Cornyn and Senator Lieberman. It requires all federal departments and agencies that invest $100 million or more annually in research to develop a public access policy that requires all final manuscripts or articles that result from federal funding to be posted in a free publicly accessible archive as soon as possible but no later than six months after publication. The bill also would require agencies to "make effective use of any law or guidance relating to the creation and reservation of a Government license that provides for the reproduction, publication, release, or other uses of a final manuscript for Federal purposes" (Sec. 4 (c)). The following could be among the agencies affected, the National Science Foundation, the Department of Energy, the Department of Transportation, the Department of Defense, and the National Aeronautics and Space Administration. This proposal, like the NIH public access policy, has generated considerable reaction. In July, 2006, the provosts of 25 universities, including Harvard, the University of Chicago, and the University of California, jointly released "An Open Letter to the Higher Education Community," supporting the bill as "good for education and good for research." Subsequently the presidents of 53 liberal arts colleges, organized by the president of Oberlin College, issued a joint letter supporting the legislation. Several library groups have also supported this proposal. Additional support has come from major New England university provosts. Some scholarly associations, academics, and publishers objected on the same grounds as objections to the NIH policy—for instance, that the costs of a broader policy would detract from research spending, the government might not maintain databases, some journals would be forced to close for lack of income, and the government should not interfere in private activities by creating such publication databases.

On October 20, 2006 a forum was held on "Improving Access to Publicly Funded Research," cosponsored by leaders of higher education and library organizations, including the Association of American Universities (AAU), the Association of Research Libraries (ARL), the Coalition for Networked Information (CNI), the National Association of State Universities and Land-Grant College (NASULGC), and the Scholarly Publishing and Academic Resources Coalition (SPARC). Many of the speakers supported S. 2695 and open access publishing of federally funded research.

Government Purpose and Copyright Issues

NIH documents indicate that its Public Access policy upholds the principles of copyright since submission of manuscripts is voluntary and the statutory fair use privilege still applies to public use of the archived articles. The agency issued guidelines for authors on how to include, in a copyright agreement with a publisher, language that acknowledges the author's obligation to provide a copy of the article to PMC .

NIH relies on obtaining permission from authors as the basis for its policy even though "NIH does not need to seek permission from journals who may acquire copyrights from authors or institutions because any copyright transfer or assignment is currently subject to the government purpose license pursuant to 45 C.F.R. 74.36." The term "government purpose license" is not used per se in the cited regulation, but is implied. NIH says it is not relying on use of government purpose license to implement its policy. The regulation reads,

The recipient may copyright any work that is subject to copyright and was developed, or for which ownership was purchased, under an award. The HHS awarding agency reserves a royalty-free, nonexclusive and irrevocable right to reproduce, publish, or otherwise use the work for Federal purposes, and to authorize others to do so (45 CFR 74.36(a)).

The concept of nonexclusive right to use the work is similar to the concept of "government purpose license" that is used in the Federal Acquisition Regulation , which governs federally funded contracts. Government purpose licensing permits agencies to disseminate to the public scientific and technical articles based on, or containing data produced from, research funded by the agency. The government may subsequently use and distribute the scientific and technical articles as submitted to a publisher or as published in a journal if the publisher has not added any original materials, such as publisher-prepared abstracts or peer review comments. However, generally an agency should obtain a publisher's written permission to reuse or republish the article as published in the journal. Use of "government purpose authority" per se to disseminate published journal articles to the public may be limited to contracts funded by those agencies whose originating or authorizing legislation mandates them to preserve and/or disseminate information to the general public about the agencies' activities and research results. Agencies may attach separate and different interpretations to this function and purpose.

Other agencies that support scientific grants are governed by OMB Circular A110-section 36, which allows copyrighting by the owner of the work produced from the award of federal funds, but gives the government a nonexclusive right to use it. Specifically,

The recipient may copyright any work that is subject to copyright and was developed, or for which ownership was purchased, under an award. The Federal awarding agency(ies) reserve a royalty-free, nonexclusive and irrevocable right to reproduce, publish, or otherwise use the work for Federal purposes, and to authorize others to do so.

The Circular A-110 language does not appear to require agencies' enabling legislation to mandate dissemination of research findings, although agency regulations generally require grantees to publish or disseminate the findings of their research and to share data generated by such research. See, for instance, the NSF Grant Policy Manual which specifies that "Investigators are expected to promptly prepare and submit for publication with authorship that accurately reflects the contributions of all those involved, all significant findings from work conducted under NSF grants." However agencies may have different rules relating to the dissemination of research findings and definitions of "Federal purpose."

If other agencies were to develop Public Access policies like NIH's, they might use a policy of voluntarily submitted manuscripts like NIH. But research funding agencies might also chose to invoke government purpose license or nonexclusive right to use policies to archive articles.

Issues Relating to Federal Open Access Archives and Publishing

In addition to NIH's Public Access policy and PMC , other federal agencies have engaged in open access activities. Several federal agencies publish free, open access, peer reviewed, Internet accessible journals. These journals include Emerging Infectious Diseases, by the Centers for Disease Control and Prevention; and Agricultural Research and the Journal of Agricultural Research , maintained by the U.S. Department of Agriculture and the National Agricultural Library. Others have free, searchable, electronically available repositories that include abstracts, links to full-text articles, and other research reports, some of which may be read online. However, some agencies have confronted serious obstacles to maintaining such systems and have been forced to terminate them. Below is an overview of agency activities and a review of some of the general issues raised about federal involvement in open access publishing and databases.

Federal Scientific and Technical Archival Databases

Some agencies maintain databases or repositories containing citations, articles or reports that resulted from government-funded research or research funded by other sources, and some include preprints of scientific and technical materials. For instance, the DOE Information Bridge allows readers to access for free all available Department of Energy (DOE) preprint report literature (preprint reports prepared for the government via grant or contract that are usually longer than articles published in journals). DOE also has a tool called E-print that allows the user to search major preprint systems and university sites where articles are posted. E-print is a gateway to over 17,208 websites and databases worldwide that hold "... e-prints in basic and applied sciences, primarily in physics but also including subject areas such as chemistry, biology and life sciences, materials science, nuclear sciences and engineering, energy research, computer and information technologies, and other disciplines of interest to DOE." The system permits documents to be "... circulated electronically to facilitate peer exchange and scientific advancement. Included are pre-publication drafts of journal articles (preprints), scholarly papers, technical communications, or similar documents relaying research results among peer groups."

Other federal agency open access systems include:

The GrayLIT Network , which includes the searchable full text of gray literature from the Defense Technical Information Center, the DOE, the NASA Jet Propulsion Lab, NASA Langley, and the Environmental Protection Agency. The Federal Research and Development Project Summaries system contains information about research projects from the DOE, the National Institutes of Health and the National Science Foundation." The U.S. Department of Agriculture's (USDA) AGRICOLA ( AGRIC ultural O n L ine A ccess) system, an online bibliographic data base which provides citations, abstracts, and links, when they are available, to published and non-published agricultural literature in the National Agricultural Library. The Astrophysics Data System (ADS) is a National Aeronautics and Space Administration (NASA)-funded project which maintains four bibliographic databases containing more than 4.2 million records, including links to external resources dealing with: Astronomy and Astrophysics, Instrumentation, Physics and Geophysics, and preprints in Astronomy. The system also contains full-text scans of much of the astronomical literature (almost 50 astrophysics journals).

Objections to Government-Operated Databases: Censorship and Competition in the Free Market

Allegations of censorship and governmental competition with free market mechanisms are often cited in opposition to government-maintained databases of scientific and technical information.

Allegations of Governmental Censorship

Some critics focus on dissemination issues and contend that governmental operation of archives and databases of abstracts and journal articles resulting from federally funded research or research funded by other sources implies government "censorship and encroachment upon scholarly discourse." Federal officials, rather than private publishers, some allege could end up determining what research gets archived or disseminated and what does not.

Curbs on Department of Energy Information Systems

Some publishers have objected to government-run scientific and technical databases containing abstracts or articles, saying these threaten their publishing activities and employees' jobs. This controversy is illustrated by the experiences of at least two DOE systems.

The DOE E-print system, described above, has been controversial, and, according to a DOE official, a few years ago several publishers threatened to prohibit publication of articles that authors posted on it. But eventually the publishers relented and now each publisher has different rules regarding the posting of preprints.

PubScience , was a U.S. Department of Energy effort to provide a free multidisciplinary database for physical sciences literature. It contained indexed abstracts or citations for federally funded and other literature published in commercial journals. Readers could access indexed abstracts for free, but were directed to the commercial website link to obtain the full text article, usually for a fee. The system was initiated on October 1, 1999 and closed on November 4, 2002. According to one article:

... the effort quickly became the target of intense lobbying, spearheaded by the Washington-based Software & Information Industry Association (SIIA), a coalition of for-profit and nonprofit members including Reed Elsevier, ISI, Chemical Abstracts Services, and Cambridge Scientific Abstracts. The SIIA claimed that such a service competed with its members' services and argued that government initiative should confine themselves to government information only.

DOE's Office of Scientific and Technical Information (OSTI) operated PubScience . According to one DOE official, intense lobbying by publishers and their associations threatened OSTI's budget. The House Appropriations committee report on the DOE FY2002 appropriation bill, H.R. 2311 ( H.Rept. 107-112 , pp. 108-109), cautioned DOE about duplication with commercial information services and asked DOE to keep its efforts focused appropriately. The existence of the commercial database Scirus and another called Infotrieve were cited as competing commercial vendors.

The Federal Database: PubChem

Efforts were made in 2005 to curtail or close an NIH database initiated to advance science by assisting basic researchers to identify chemicals related to genetics and cellular research. According several articles, the American Chemical Society (ACS) initially sought closure, and then modified its position to seek limitations, on PubChem , which, it says, duplicates ACS's commercial, fee-based Chemical Abstract Service (CAS) .

Reportedly, NIH launched PubChem in fall 2004 to provide data and to index hyperlinks to articles on the chemical structures of small organic molecules and information on their biological activities to support the "molecular libraries and imaging component of the NIH Roadmap Initiative," which is a strategic planning process initiated by the NIH Director. PubChem contains data organized into three databases: PubChem Substance , PubChem Compound , and PubChem BioAssay . According to NIH,

Links from PubChem 's chemical structure records to other Entrez databases provide information on biological properties. These include links to PubMed scientific literature and NCBI's protein 3D structure resource. Links to PubChem's bioassay database present the results of biological screening. Links to depositor web sites provide further information.

The system, reportedly, will expand as it includes more data from the Molecular Libraries centers and data from other online open access chemical database repositories.

PubChem , operated by the National Center for Biotechnology Information (NCBI), also provides readers with free access to links to other NCBI databases. It is operated by 13 staff members with a budget of about $3 million.

According to the ACS, PubChem jeopardizes its own CAS service, which is reported to "... employ ... more than 1,200 people in Columbus, Ohio, and makes a significant contribution to the society's $317 million in annual revenue from publications." CAS subscribers receive summary data on chemicals and links to about 24 million abstracts from about 9,000 journals, as well as patent abstracts on more than 25 million chemical substances. NIH is reported to have said that its database provides indexes and links only to biological journals that overlap only slightly with the journals linked by CAS and focuses on "biological information such as protein structures and toxicology," which CAS does not deal with, not broader chemical reactions which CAS covers. An NIH official, Christopher Austin, senior advisor at the NIH Chemical Genomics Center at the National Human Genome Research Institute, was reported to have said that limitation of PubChem would have profoundly negative effects on medical discoveries. One report said "The overlap between the two databases occurs in the indexes of chemical names. NIH maintains the overlap is 'quite modest' and for the most part is 'complementary' to CAS. ACS disagrees, saying PubChem duplicates CAS' platform and replicates its search features and information." Several articles noted that the ACS lobbied Members of Congress, especially Appropriations Committee members, to have PubChem terminated or limited to include only compounds derived from federally funded R&D and to avoid overlap with a commercial enterprise.

Both the House Appropriations Committee and the Senate Appropriations Committee addressed this issue in their reports on the FY2006 appropriations bill that includes appropriations for NIH ( H.R. 3010 ). They did not reduce funding for the database. Both reports said essentially the same thing—that they understood that the database will include chemical compound information from the NIH-funded molecular libraries screening center network and from other sources. But they both expressed concern about duplication of effort with the private sector and urged NIH to work with private sector publishers to avoid unnecessary duplication. After conference committee action, the bill was cleared on December 21, 2005 for the President's signature and signed as P.L. 109-149 .

Reportedly, "Supporters of PubChem see the House language as a victory for NIH." An ACS official is reported to have said that the language is a "'tremendous step in the right direction.' " In late August 2005 NIH rejected an offer from ACS to create and manage for free "a database for NIH to deposit bioassay data from its molecular screening project." Instead, on September 1, 2005, NIH announced in the Federal Register that it was inviting participation from private sector providers and users of chemical information to participate in a new working group "to advise on interactions with private sector information providers in the development of PubChem." Subsequently, it was reported in October 2005 that the American Chemical Society objected to what it characterized as the retrospective process that the group was to use to assess biomedical relevance of compounds in the data base, and sought that prospective analysis be used instead. Reportedly, NIH database managers said that NIH cannot know "...'a priori which compounds should and shouldn't go into the collection.'" The private-sector panel and NIH officials met on December 19, 2005, and, reportedly, "No definitive conclusions were reached at the end of the meeting, although industry representatives said they left with a better understanding of PubChem and of NIH's intentions. Agency officials said it was unclear whether the working group would meet again."

According to NIH, many new private sector depositors have contributed to NIH's PubChem system. A "live" list of depositors is available at http://pubchem.ncbi.nlm.nih.gov/sources/sources.cgi . This site report that

MDL/Elsevier deposited over 2 million structures under the "DiscoveryGate" and "xPharm", names, for example, and Prous Science deposited several thousand structures from their "Drugs of the Future" review journal. This shows that some of the major providers in the chemical information industry have found PubChem useful and complementary to their commercial services.

Speculation About Differences in Federal Agency Policies

There are no unequivocal answers as to why some agencies can maintain open access systems more easily than others. It may be that publishers, despite their misgivings, moderated their opposition to congressional action to put manuscripts on NIH's PubMed Central since the posted items are limited to those that resulted from NIH funding. However, NIH may be in a different position from other federal agencies since it has a mandate to preserve and provide health information to the public; other agencies may not have such clear mandates to distribute information and the results of their research funding to the public. Furthermore, support for NIH's open access activities seems based not only on the need to allow taxpayers access to results of research their taxes funded, but also on the emotional argument about need for rapid access to information to improve health and save lives, a compelling rationale to many Members of Congress.

Reportedly, DOE's Scientific and Technical Information Advisory Board is discussing, at the highest levels, the question of whether it should establish an open access policy like NIH's to make DOE-funded articles available in its own database and is preparing a report on this subject. According to several federal agency staff, it seems that in the absence of guidance from the congressional appropriations committees, agencies, other than NIH, would likely find it difficult to mount a system like NIH's because of publisher opposition.

Interagency Activities

Scientific publishing and communications methods are slowly changing as Internet publishing becomes more prevalent. Some observers say that government-supported researchers and sponsoring agency staff should participate in shaping these new methods of delivering scientific information. CENDI (the Commerce, Energy, NASA, Defense Information Managers Group), an interagency committee composed of senior Scientific and Technical Information (STI) managers from 12 U.S. federal agencies, has working groups that are studying open access publishing, indexing, and archiving and has issued reports on it to help develop uniform standards and methods of international cooperation.

International Activities

Several international organizations and other countries are examining wider implementation of open access publishing. Following the release in 2003 of the "Berlin Declaration" which called for open access to knowledge and its signing by representatives of selected European universities, research groups, and government sectors, the European Union began a study on changes in markets for scientific and technical publishing in Europe. Among its topics of inquiry is the subject of "open access to research findings for all and the need to reconcile authors' rights and the economic interests of publishers." The report, Study on the Economic and Technical Evolution of the Scientific Publication Markets in Europe , January 2006, endorsed but did not require open access to publicly funded research.

In 2004, the Organization for Economic Cooperation and Development's (OECD) science ministers declared their commitment to a "... principle that research data from public funding should be openly available" on the rationale that providing such access promotes long-term economic benefits, more informed governmental decisionmaking, and hastens the advancement of scientific research. The ministers asked OECD to develop guidelines to "facilitate optimal cost-effective access to digital research data from public funding ..." that would be balanced in terms of opening access while recognizing "the need for restriction of access in some instances to protect social, scientific, and economic interests." The guidelines will be released after approval by the OECD Council. The 2004 OECD work was based, in part, on a report that was funded by the U.S. National Science Foundation. According to the report's authors, "The ultimate goal ... is to make data sharing and the principle of open access the rule rather than the exception."

Another OECD report published on September 2, 2005, as Digital Broadband Content: Scientific Publishing. It reiterated the view that governments should increase access to findings from publicly funded research to maximize social returns on public investments and presented examples and comprehensive pro and con analyses of currently used business models of open access publishing and open access archives. It also summarized the pros and cons of "hybrid" business models which distribute publishing costs among authors and users. One example is a

... two-part tariff for author fees ... with fees levied for submission and publication serving to reduce the tendency for multiple and speculative submission of papers for publication, and enabling journals to cover the costs of quality through support for higher rejection rates. Such as model might also serve to increase revenue certainty for publishers of open access author pays variant journals and, by reducing the cost of publication in them, enable them better to compete for authors with subscription-based journals. However, user resistance would be a strong possibility compared with simpler author pays models.

The report also proposed variations of another hybrid model involving "... segmentation of a journal into subscription and open access on an article-by-article basis, according to the author's preference and willingness/ability to pay." Apparently a number of publishers have already adopted such practices, and the OECD report concluded "Such a model may be a useful way for a journal title to migrate from a subscription model to an open access model over time, with the pace and direction of change dictated by author preferences."

As noted above, there has been considerable governmental and nongovernmental activity to promote open access publishing in the United Kingdom. Some scientific and medical researchers in Britain took steps to make research results freely available via the British open access publisher, BioMedCentral . Subsequently, in 2004, the Science and Technology Committee of Britain's House of Commons issued a report endorsing open access to research results by proposing to require authors to deposit their published papers in online archives and journals using an author pays model and eliminating subscription fees. It also recommended that government agencies mandate that government-funded researchers put their articles into the archives and that the government pay some publishing fees. In November 2004 the U.K. government (the Department of Trade and Industry) rejected the proposal, maintaining there is no indication that access to scientific journals is impeded under current publishing methods, and that according to the government, "the true costs of open-access publishing are still not clear ..." and "it is 'not obvious ... that the 'author pays' business model would give better value for money than the current one...." In June 2005, the United Kingdom Research Councils (RCUK), the main British supporter of publicly funded research, "which distribute[s] most government science funding," issued for comment a draft policy which mandates researchers it funds to archive their journal articles and conference papers "in a free public archive 'at the earliest opportunity, wherever possible at or around the time of publication.'" But the rules may allow publishers to continue to embargo archiving articles until many months after publication, since the council says "its mandate is 'subject to copyright and licensing arrangements' that can restrict what authors do." Costs of publishing in "author pays" journals would be covered by the Research Councils' funding grant "subject to justification of cost-effectiveness." The British government said it would review its policy options on this issue taking into consideration the draft RCUK policy and any changes to it, as well as other information. The executive board of the RCUK issued a policy statement in the summer of 2006, saying that "...all peer-reviewed journal papers produced by publicly funded research must be made available for free soon after they're completed." But "exactly what that means was not specified, and RCUK left each research council to set its own rules." RCUK also said it would assess the results of a two-year analysis of the impact of mandating open access and review the policies in 2008. The Wellcome Trust, a large British medical foundation, recently announced that it requires all papers produced with its support "... to be submitted to the NIH archive or to the British equivalent that is being developed."

The British Royal Society, an advisory body to the government, which also publishes seven peer-reviewed journals, whose papers can be accessed without charge a year after publication, issued a position paper opposing the RCUK policy. It cited, in particular, the lack of assessment about cost effectiveness of institutional archives, subject-based repositories, and self-archiving; the potential for the proposed policy to threaten survival of some existing journals; and the problems observed with quality control of articles appearing in some open access publications. Apparently some learned societies fear that libraries will cancel subscriptions to their professional societies' publications.

Other foreign and international organization open access activities are summarized in Julie M. Esanau and Paul F. Uhlir, eds., Open Access and the Public Domain in Digital Data an Information for Science, Proceedings of an International Symposium, Published by U.S. National Committee for CODATA, National Academies Press, Washington, D.C., 2004.

Summary of Policy Issues and Questions

Policies for open access journals and citation repositories are evolving and contentious issues may be raised during the 109 th Congress. Those that have implications for academic institutions are discussed in the Appendix . Other policy issues and questions are emerging, including the following.

Copyright

Assessment of which federal agencies, in addition to NIH, would seek to archive and provide free public access to manuscripts or articles reporting the results of research that they supported. Analysis of which agencies might seek to provide access to manuscripts or articles, using government purpose license or nonexclusive right to use published articles, regardless of copyright ownership.

Quality Control

Comparison of the quality of peer review processes and of peer reviewed articles that are published in traditional, subscriber-pays and open access journals. Monitoring of whether academic reward systems react differently to articles published by traditional publishers or open access publishers and assessing the implications for professional advancement of researchers and teachers in academic promotion and tenure systems. Assessing the positive and negative impacts on the speed and quality of scientific research, knowledge synthesis, and knowledge accumulation flowing from open access publishing and open access citation/abstract archives in comparison with traditional publishing and archival methods. Analysis of publisher actions to identify whether or not authors who seek copyright agreement terms allowing them to post manuscripts in PMC are penalized.

Monitoring of NIH Public Access Activities and Other Federal Initiatives, Including PubChem

Assessment of rates of voluntary participation by NIH-funded authors in the Public Access policy and determination of whether there are any negative impacts—from research sponsors or the scientific community—on NIH-funded authors who may not submit articles for dissemination in PMC . Determination if federal open access databases and archival repositories should be limited to providing access only to publications that result from federally funded R&D. Assessment of proposals for governmental citation archives to link to publisher's websites to read published articles, as opposed to posting articles on a free access government system. Follow-up to congressional mandates that NIH monitor the implementation of its Public Access policy, that it work with traditional, subscriber-pays publishers to monitor the impacts and costs of open access archiving of text on PMC, as it posts what is estimated to be thousands (possibly 60,000) of additional articles on the system, and that it work with publishers to monitor impacts on the integrity of peer review processes. (The NIH Director estimated that the added costs for posting all NIH-funded research studies on PubMed Central ' s digital library at around $2 to $4 million annually. According to NIH, agency-supported research resulted in 60,000 to 65,000 published papers in 2003.) With respect to PubChem , assessing cooperation between NIH and private groups on clarifying the possible overlap between NIH's archive and that of private activities, including the American Chemical Society's Chemical Abstracts Service . Analysis of the impacts on biomedical research in general and on NIH's research and its strategically planned genomic research initiatives if the scope of PubChem were to be limited.

Who Pays?

Determining whether federal regulations for support of contracts and grants will continue to allow agencies to pay individual authors or academic institutions for the costs of publishing articles in open access journals as part of the research process, especially if open access publishing becomes more widespread and a substantial portion of the scientific and technical publishing market. A related issue is determining the possible effects on research support funding. Given that federal research sponsors allow some journal publishing and subscription costs to be counted as part of the costs to conduct federally sponsored research, comparing the actual total costs to the government for publishing and reading of scientific articles published traditionally as opposed to those published using open access models.

Economic Implications

Analysis of the role that the federal government should play in funding the start-up of nongovernmental citation archives and repositories for scientific and technical articles, if the government also initiates governmental activities with similar purposes. Economic analysis of the impacts on the commercial publishing industry (revenues, employment, sustainability, etc.) if open access publishing and archiving activities continue to expand. Examination of the extent to which professional scientific societies utilize the profits from publishing to support their activities and of alternative sources of funding for these activities.

Appendix. Open Access Publishing: Selected Questions in Academia

Continuing questions relating to controversial issues about open access publishing were raised by Andy Gass and Helen Doyle, "The Reality of Open-Access Journal Articles," Chronicle of Higher Education, February 18, 2005. They conclude that although there are problems, support is growing in academia for open access journals. Remaining questions include:

What will become of the market for secondary filters of primary research articles, services like BioMed Central's Faculty of 1000, which highlight important papers published in a wide swath of journals? Will fee-for-access ventures that collect open-access articles become a new cash cow for publishers? At present, faculty members offer their recommendations to the filtering services free, and publishers sell their aggregated opinions to institutions—will established professors go on contributing their free labor to such entrepreneurial enterprises? How will the role of the research library change, as open-access scholarly communication becomes more widely practiced? To what extent will librarians be freed from the burdens of subscription management? Many university libraries now encourage open access by subsidizing a portion of the publication charges in open-access venues for authors affiliated with the university, through channels like our employer's institutional membership program. Will those subsidies continue? If so, will they continue to be paid from libraries' budgets, or will they come from research budgets—a source that would be more consistent with the view of open-access proponents that costs of publication should be part of the costs of conducting research? Or will external granting agencies, many of which already pay scientists' page charges and color-illustration fees, assume the full costs of their investigators' open-access publications? Will libraries continue to serve as intermediaries through which researchers find open-access information, as well as that available only through subscription, and how? Those questions relate not just to academic libraries, but to the mission of colleges and universities. The time has come for a comprehensive review of how best to pay for the dissemination of professors' work. How will reduced legal barriers to reusing articles—a stipulation of most formal definitions of open access—affect teaching, research, and other scholarly activities? There are, of course, good precedents for having few or no legal restrictions on the reuse of scholarly work: Every article published by an employee of the NIH is in the public domain. Some more-restrictive open-access licenses now available, like the Creative Commons attribution license in use for articles from our employer and from BioMed Central, permit users to reproduce scholarly work in any medium, for any purpose, as long as the author receives proper credit. What kinds of educational tools will such licenses make possible? For example, will we see a proliferation of online articles enhanced with explanatory links and informational sidebars, which make scientific discoveries more comprehensible to a wide audience? Will such resources be produced by commercial enterprises? By nonprofit organizations? Or by networks of volunteers, as is the case with open-source computer software? Will open-access articles enable more researchers from less-developed countries to work on the frontiers of science? Given that all credible open-access journals waive publication fees for authors who can't afford to pay them, increased availability—and therefore knowledge—of the literature might well allow scientists in the developing world to increase their output of cutting-edge work. Would that change, in turn, help resolve the "10/90 gap"—the unfortunate reality that less than 10 percent of the global expenditure on medical research goes to study the predominant health needs of 90 percent of the world's population? Most important, what kinds of discoveries might result from searchable, open archives of peer-reviewed, full-text scientific literature? The aggregation of gene sequences in a single, freely accessible information space (GenBank) has spawned entire fields of research; will open access to journal articles have a similar effect on areas of work that could benefit from "mining" full texts and figures? Clearly, comprehensive collections of open-access literature would make it much easier to systematically review published medical studies. Will open-access literature lead to frequent discoveries of correlations between phenomena previously thought to be unrelated? Will it spark more open access to data sets and databases of laboriously compiled and annotated information? The potential for open access to lead to new discoveries is its single most compelling asset, though one that is frequently overlooked.