lovingscience/chembl-v37-raw-activities huggingface dataset:
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL24 (SINGLE PROTEIN), Homo sapiens
UniProt: P61254
Assay: Binding affinity to human RPL26 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 6181.28 nM (pChEMBL 5.210000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL24 (SINGLE PROTEIN), Homo sapiens
UniProt: P61254
Assay: Binding affinity to human RPL26 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 6181.28 nM (pChEMBL 5.210000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL27 (SINGLE PROTEIN), Homo sapiens
UniProt: P61353
Assay: Binding affinity to human RPL27 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 5258.51 nM (pChEMBL 5.28000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL27 (SINGLE PROTEIN), Homo sapiens
UniProt: P61353
Assay: Binding affinity to human RPL27 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 5258.51 nM (pChEMBL 5.28000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL15 (SINGLE PROTEIN), Homo sapiens
UniProt: P46776
Assay: Binding affinity to human RPL27A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 5946.46 nM (pChEMBL 5.230000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL15 (SINGLE PROTEIN), Homo sapiens
UniProt: P46776
Assay: Binding affinity to human RPL27A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 5946.46 nM (pChEMBL 5.230000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL3 (SINGLE PROTEIN), Homo sapiens
UniProt: P39023
Assay: Binding affinity to human RPL3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2638.87 nM (pChEMBL 5.579999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL3 (SINGLE PROTEIN), Homo sapiens
UniProt: P39023
Assay: Binding affinity to human RPL3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2638.87 nM (pChEMBL 5.579999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL30 (SINGLE PROTEIN), Homo sapiens
UniProt: P62888
Assay: Binding affinity to human RPL30 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 25.7 nM (pChEMBL 7.590000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL30 (SINGLE PROTEIN), Homo sapiens
UniProt: P62888
Assay: Binding affinity to human RPL30 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 25.7 nM (pChEMBL 7.590000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL31 (SINGLE PROTEIN), Homo sapiens
UniProt: P62899
Assay: Binding affinity to human RPL31 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 14938.53 nM (pChEMBL 4.829999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL31 (SINGLE PROTEIN), Homo sapiens
UniProt: P62899
Assay: Binding affinity to human RPL31 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 14938.53 nM (pChEMBL 4.829999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL29 (SINGLE PROTEIN), Homo sapiens
UniProt: P42766
Assay: Binding affinity to human RPL35 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 64921.94 nM (pChEMBL 4.190000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL29 (SINGLE PROTEIN), Homo sapiens
UniProt: P42766
Assay: Binding affinity to human RPL35 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 64921.94 nM (pChEMBL 4.190000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL33 (SINGLE PROTEIN), Homo sapiens
UniProt: P18077
Assay: Binding affinity to human RPL35A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 38.82 nM (pChEMBL 7.409999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL33 (SINGLE PROTEIN), Homo sapiens
UniProt: P18077
Assay: Binding affinity to human RPL35A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 38.82 nM (pChEMBL 7.409999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL36 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y3U8
Assay: Binding affinity to human RPL36 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 10494.82 nM (pChEMBL 4.980000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL36 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y3U8
Assay: Binding affinity to human RPL36 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 10494.82 nM (pChEMBL 4.980000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL38 (SINGLE PROTEIN), Homo sapiens
UniProt: P63173
Assay: Binding affinity to human RPL38 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 8355.34 nM (pChEMBL 5.079999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL38 (SINGLE PROTEIN), Homo sapiens
UniProt: P63173
Assay: Binding affinity to human RPL38 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 8355.34 nM (pChEMBL 5.079999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL4 (SINGLE PROTEIN), Homo sapiens
UniProt: P36578
Assay: Binding affinity to human RPL4 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 4728.58 nM (pChEMBL 5.329999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL4 (SINGLE PROTEIN), Homo sapiens
UniProt: P36578
Assay: Binding affinity to human RPL4 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 4728.58 nM (pChEMBL 5.329999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL18 (SINGLE PROTEIN), Homo sapiens
UniProt: P46777
Assay: Binding affinity to human RPL5 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 862.48 nM (pChEMBL 6.059999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL18 (SINGLE PROTEIN), Homo sapiens
UniProt: P46777
Assay: Binding affinity to human RPL5 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 862.48 nM (pChEMBL 6.059999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL30 (SINGLE PROTEIN), Homo sapiens
UniProt: P18124
Assay: Binding affinity to human RPL7 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 16.7 nM (pChEMBL 7.78000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL30 (SINGLE PROTEIN), Homo sapiens
UniProt: P18124
Assay: Binding affinity to human RPL7 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 16.7 nM (pChEMBL 7.78000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL8 (SINGLE PROTEIN), Homo sapiens
UniProt: P62424
Assay: Binding affinity to human RPL7A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2568.73 nM (pChEMBL 5.590000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL8 (SINGLE PROTEIN), Homo sapiens
UniProt: P62424
Assay: Binding affinity to human RPL7A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2568.73 nM (pChEMBL 5.590000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL2 (SINGLE PROTEIN), Homo sapiens
UniProt: P62917
Assay: Binding affinity to human RPL8 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 50.25 nM (pChEMBL 7.300000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL2 (SINGLE PROTEIN), Homo sapiens
UniProt: P62917
Assay: Binding affinity to human RPL8 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 50.25 nM (pChEMBL 7.300000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL6 (SINGLE PROTEIN), Homo sapiens
UniProt: P32969
Assay: Binding affinity to human RPL9 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1273.11 nM (pChEMBL 5.889999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL6 (SINGLE PROTEIN), Homo sapiens
UniProt: P32969
Assay: Binding affinity to human RPL9 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1273.11 nM (pChEMBL 5.889999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein P1 (SINGLE PROTEIN), Homo sapiens
UniProt: P05386
Assay: Binding affinity to human RPLP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 12.52 nM (pChEMBL 7.900000095367432)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein P1 (SINGLE PROTEIN), Homo sapiens
UniProt: P05386
Assay: Binding affinity to human RPLP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 12.52 nM (pChEMBL 7.900000095367432)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (SINGLE PROTEIN), Homo sapiens
UniProt: P04843
Assay: Binding affinity to human RPN1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 129.83 nM (pChEMBL 6.889999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (SINGLE PROTEIN), Homo sapiens
UniProt: P04843
Assay: Binding affinity to human RPN1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 129.83 nM (pChEMBL 6.889999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (SINGLE PROTEIN), Homo sapiens
UniProt: P04844
Assay: Binding affinity to human RPN2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 873.66 nM (pChEMBL 6.059999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (SINGLE PROTEIN), Homo sapiens
UniProt: P04844
Assay: Binding affinity to human RPN2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 873.66 nM (pChEMBL 6.059999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS10 (SINGLE PROTEIN), Homo sapiens
UniProt: P46783
Assay: Binding affinity to human RPS10 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 41.98 nM (pChEMBL 7.380000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS10 (SINGLE PROTEIN), Homo sapiens
UniProt: P46783
Assay: Binding affinity to human RPS10 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 41.98 nM (pChEMBL 7.380000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS17 (SINGLE PROTEIN), Homo sapiens
UniProt: P62280
Assay: Binding affinity to human RPS11 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 25.09 nM (pChEMBL 7.599999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS17 (SINGLE PROTEIN), Homo sapiens
UniProt: P62280
Assay: Binding affinity to human RPS11 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 25.09 nM (pChEMBL 7.599999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS12 (SINGLE PROTEIN), Homo sapiens
UniProt: P25398
Assay: Binding affinity to human RPS12 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 171.1 nM (pChEMBL 6.769999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS12 (SINGLE PROTEIN), Homo sapiens
UniProt: P25398
Assay: Binding affinity to human RPS12 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 171.1 nM (pChEMBL 6.769999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS15 (SINGLE PROTEIN), Homo sapiens
UniProt: P62277
Assay: Binding affinity to human RPS13 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2208.07 nM (pChEMBL 5.659999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS15 (SINGLE PROTEIN), Homo sapiens
UniProt: P62277
Assay: Binding affinity to human RPS13 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2208.07 nM (pChEMBL 5.659999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS11 (SINGLE PROTEIN), Homo sapiens
UniProt: P62263
Assay: Binding affinity to human RPS14 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 5299.42 nM (pChEMBL 5.28000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS11 (SINGLE PROTEIN), Homo sapiens
UniProt: P62263
Assay: Binding affinity to human RPS14 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 5299.42 nM (pChEMBL 5.28000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS19 (SINGLE PROTEIN), Homo sapiens
UniProt: P62841
Assay: Binding affinity to human RPS15 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 4043.88 nM (pChEMBL 5.389999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS19 (SINGLE PROTEIN), Homo sapiens
UniProt: P62841
Assay: Binding affinity to human RPS15 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 4043.88 nM (pChEMBL 5.389999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS8 (SINGLE PROTEIN), Homo sapiens
UniProt: P62244
Assay: Binding affinity to human RPS15A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 6.414 nM (pChEMBL 8.1899995803833)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS8 (SINGLE PROTEIN), Homo sapiens
UniProt: P62244
Assay: Binding affinity to human RPS15A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 6.414 nM (pChEMBL 8.1899995803833)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS9 (SINGLE PROTEIN), Homo sapiens
UniProt: P62249
Assay: Binding affinity to human RPS16 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 49.74 nM (pChEMBL 7.300000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS9 (SINGLE PROTEIN), Homo sapiens
UniProt: P62249
Assay: Binding affinity to human RPS16 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 49.74 nM (pChEMBL 7.300000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS17 (SINGLE PROTEIN), Homo sapiens
UniProt: P08708
Assay: Binding affinity to human RPS17 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 21799.14 nM (pChEMBL 4.659999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS17 (SINGLE PROTEIN), Homo sapiens
UniProt: P08708
Assay: Binding affinity to human RPS17 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 21799.14 nM (pChEMBL 4.659999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS13 (SINGLE PROTEIN), Homo sapiens
UniProt: P62269
Assay: Binding affinity to human RPS18 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2790.09 nM (pChEMBL 5.550000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS13 (SINGLE PROTEIN), Homo sapiens
UniProt: P62269
Assay: Binding affinity to human RPS18 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2790.09 nM (pChEMBL 5.550000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS19 (SINGLE PROTEIN), Homo sapiens
UniProt: P39019
Assay: Binding affinity to human RPS19 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 645.19 nM (pChEMBL 6.190000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS19 (SINGLE PROTEIN), Homo sapiens
UniProt: P39019
Assay: Binding affinity to human RPS19 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 645.19 nM (pChEMBL 6.190000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS5 (SINGLE PROTEIN), Homo sapiens
UniProt: P15880
Assay: Binding affinity to human RPS2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 80.43 nM (pChEMBL 7.090000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS5 (SINGLE PROTEIN), Homo sapiens
UniProt: P15880
Assay: Binding affinity to human RPS2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 80.43 nM (pChEMBL 7.090000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS10 (SINGLE PROTEIN), Homo sapiens
UniProt: P60866
Assay: Binding affinity to human RPS20 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 371.02 nM (pChEMBL 6.429999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS10 (SINGLE PROTEIN), Homo sapiens
UniProt: P60866
Assay: Binding affinity to human RPS20 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 371.02 nM (pChEMBL 6.429999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS21 (SINGLE PROTEIN), Homo sapiens
UniProt: P63220
Assay: Binding affinity to human RPS21 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 59972.96 nM (pChEMBL 4.21999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS21 (SINGLE PROTEIN), Homo sapiens
UniProt: P63220
Assay: Binding affinity to human RPS21 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 59972.96 nM (pChEMBL 4.21999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS12 (SINGLE PROTEIN), Homo sapiens
UniProt: P62266
Assay: Binding affinity to human RPS23 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 8.732 nM (pChEMBL 8.0600004196167)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS12 (SINGLE PROTEIN), Homo sapiens
UniProt: P62266
Assay: Binding affinity to human RPS23 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 8.732 nM (pChEMBL 8.0600004196167)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS24 (SINGLE PROTEIN), Homo sapiens
UniProt: P62847
Assay: Binding affinity to human RPS24 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 357.41 nM (pChEMBL 6.449999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS24 (SINGLE PROTEIN), Homo sapiens
UniProt: P62847
Assay: Binding affinity to human RPS24 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 357.41 nM (pChEMBL 6.449999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS25 (SINGLE PROTEIN), Homo sapiens
UniProt: P62851
Assay: Binding affinity to human RPS25 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2635.03 nM (pChEMBL 5.579999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS25 (SINGLE PROTEIN), Homo sapiens
UniProt: P62851
Assay: Binding affinity to human RPS25 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2635.03 nM (pChEMBL 5.579999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS27 (SINGLE PROTEIN), Homo sapiens
UniProt: P42677
Assay: Binding affinity to human RPS27 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 7653.2 nM (pChEMBL 5.119999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS27 (SINGLE PROTEIN), Homo sapiens
UniProt: P42677
Assay: Binding affinity to human RPS27 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 7653.2 nM (pChEMBL 5.119999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ribosomal protein eS27-like (SINGLE PROTEIN), Homo sapiens
UniProt: Q71UM5
Assay: Binding affinity to human RPS27L incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 6464.36 nM (pChEMBL 5.190000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ribosomal protein eS27-like (SINGLE PROTEIN), Homo sapiens
UniProt: Q71UM5
Assay: Binding affinity to human RPS27L incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 6464.36 nM (pChEMBL 5.190000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS28 (SINGLE PROTEIN), Homo sapiens
UniProt: P62857
Assay: Binding affinity to human RPS28 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 230.84 nM (pChEMBL 6.639999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS28 (SINGLE PROTEIN), Homo sapiens
UniProt: P62857
Assay: Binding affinity to human RPS28 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 230.84 nM (pChEMBL 6.639999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS14 (SINGLE PROTEIN), Homo sapiens
UniProt: P62273
Assay: Binding affinity to human RPS29 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 107.78 nM (pChEMBL 6.96999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS14 (SINGLE PROTEIN), Homo sapiens
UniProt: P62273
Assay: Binding affinity to human RPS29 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 107.78 nM (pChEMBL 6.96999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS3 (SINGLE PROTEIN), Homo sapiens
UniProt: P23396
Assay: Binding affinity to human RPS3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 3.858 nM (pChEMBL 8.40999984741211)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS3 (SINGLE PROTEIN), Homo sapiens
UniProt: P23396
Assay: Binding affinity to human RPS3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 3.858 nM (pChEMBL 8.40999984741211)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS1 (SINGLE PROTEIN), Homo sapiens
UniProt: P61247
Assay: Binding affinity to human RPS3A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2452.47 nM (pChEMBL 5.610000133514404)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS1 (SINGLE PROTEIN), Homo sapiens
UniProt: P61247
Assay: Binding affinity to human RPS3A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2452.47 nM (pChEMBL 5.610000133514404)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS4, X isoform (SINGLE PROTEIN), Homo sapiens
UniProt: P62701
Assay: Binding affinity to human RPS4X incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 29.63 nM (pChEMBL 7.53000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS4, X isoform (SINGLE PROTEIN), Homo sapiens
UniProt: P62701
Assay: Binding affinity to human RPS4X incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 29.63 nM (pChEMBL 7.53000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS7 (SINGLE PROTEIN), Homo sapiens
UniProt: P46782
Assay: Binding affinity to human RPS5 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 176.41 nM (pChEMBL 6.75)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS7 (SINGLE PROTEIN), Homo sapiens
UniProt: P46782
Assay: Binding affinity to human RPS5 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 176.41 nM (pChEMBL 6.75)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS6 (SINGLE PROTEIN), Homo sapiens
UniProt: P62753
Assay: Binding affinity to human RPS6 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 14.44 nM (pChEMBL 7.840000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS6 (SINGLE PROTEIN), Homo sapiens
UniProt: P62753
Assay: Binding affinity to human RPS6 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 14.44 nM (pChEMBL 7.840000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ribosomal protein S6 kinase alpha-1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q15418
Assay: Binding affinity to human RPS6KA1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 5733.17 nM (pChEMBL 5.239999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ribosomal protein S6 kinase alpha-1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q15418
Assay: Binding affinity to human RPS6KA1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 7624.01 nM (pChEMBL 5.119999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ribosomal protein S6 kinase alpha-3 (SINGLE PROTEIN), Homo sapiens
UniProt: P51812
Assay: Binding affinity to human RPS6KA3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 3.829 nM (pChEMBL 8.420000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ribosomal protein S6 kinase alpha-3 (SINGLE PROTEIN), Homo sapiens
UniProt: P51812
Assay: Binding affinity to human RPS6KA3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 5.282 nM (pChEMBL 8.279999732971191)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ribosomal protein S6 kinase alpha-4 (SINGLE PROTEIN), Homo sapiens
UniProt: O75676
Assay: Binding affinity to human RPS6KA4 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 8.766 nM (pChEMBL 8.0600004196167)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ribosomal protein S6 kinase alpha-4 (SINGLE PROTEIN), Homo sapiens
UniProt: O75676
Assay: Binding affinity to human RPS6KA4 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 14.2 nM (pChEMBL 7.849999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ribosomal protein S6 kinase alpha-6 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UK32
Assay: Binding affinity to human RPS6KA6 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 310.12 nM (pChEMBL 6.510000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ribosomal protein S6 kinase alpha-6 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UK32
Assay: Binding affinity to human RPS6KA6 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 735.26 nM (pChEMBL 6.130000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS7 (SINGLE PROTEIN), Homo sapiens
UniProt: P62081
Assay: Binding affinity to human RPS7 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2239.95 nM (pChEMBL 5.650000095367432)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS7 (SINGLE PROTEIN), Homo sapiens
UniProt: P62081
Assay: Binding affinity to human RPS7 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2239.95 nM (pChEMBL 5.650000095367432)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS8 (SINGLE PROTEIN), Homo sapiens
UniProt: P62241
Assay: Binding affinity to human RPS8 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1621.13 nM (pChEMBL 5.789999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS8 (SINGLE PROTEIN), Homo sapiens
UniProt: P62241
Assay: Binding affinity to human RPS8 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1621.13 nM (pChEMBL 5.789999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS4 (SINGLE PROTEIN), Homo sapiens
UniProt: P46781
Assay: Binding affinity to human RPS9 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 10739.14 nM (pChEMBL 4.96999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS4 (SINGLE PROTEIN), Homo sapiens
UniProt: P46781
Assay: Binding affinity to human RPS9 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 10739.14 nM (pChEMBL 4.96999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS2 (SINGLE PROTEIN), Homo sapiens
UniProt: P08865
Assay: Binding affinity to human RPSA incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1958.15 nM (pChEMBL 5.710000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS2 (SINGLE PROTEIN), Homo sapiens
UniProt: P08865
Assay: Binding affinity to human RPSA incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1958.15 nM (pChEMBL 5.710000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ribosome-binding protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9P2E9
Assay: Binding affinity to human RRBP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 11343.99 nM (pChEMBL 4.949999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ribosome-binding protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9P2E9
Assay: Binding affinity to human RRBP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 11343.99 nM (pChEMBL 4.949999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ribonucleoside-diphosphate reductase large subunit (SINGLE PROTEIN), Homo sapiens
UniProt: P23921
Assay: Binding affinity to human RRM1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1669.28 nM (pChEMBL 5.78000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ribonucleoside-diphosphate reductase large subunit (SINGLE PROTEIN), Homo sapiens
UniProt: P23921
Assay: Binding affinity to human RRM1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1669.28 nM (pChEMBL 5.78000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: RNA-splicing ligase RtcB homolog (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y3I0
Assay: Binding affinity to human RTCB incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 30985.69 nM (pChEMBL 4.510000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: RNA-splicing ligase RtcB homolog (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y3I0
Assay: Binding affinity to human RTCB incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 30985.69 nM (pChEMBL 4.510000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Reticulon-3 (SINGLE PROTEIN), Homo sapiens
UniProt: O95197
Assay: Binding affinity to human RTN3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 34103.08 nM (pChEMBL 4.46999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32