lovingscience/chembl-v37-raw-activities huggingface dataset:
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-substrate-selected resistant cell line S1, Topotecan treatment, using 10 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 77 nM (pChEMBL 7.110000133514404)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-substrate-selected resistant cell line S1, Cisplatin treatment, using 0 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 1770 nM (pChEMBL 5.75)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-substrate-selected resistant cell line S1, Cisplatin treatment, using 3 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 2016 nM (pChEMBL 5.699999809265137)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-substrate-selected resistant cell line S1, Cisplatin treatment, using 10 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 2268 nM (pChEMBL 5.639999866485596)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-substrate-selected resistant cell line S1-M1-80, Mitoxantrone treatment, using 0 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 2700 nM (pChEMBL 5.570000171661377)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-substrate-selected resistant cell line S1-M1-80, Mitoxantrone treatment, using 3 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 540 nM (pChEMBL 6.269999980926514)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-substrate-selected resistant cell line S1-M1-80, Mitoxantrone treatment, using 10 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 133 nM (pChEMBL 6.880000114440918)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-substrate-selected resistant cell line S1-M1-80, SN-38 treatment, using 0 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 2336 nM (pChEMBL 5.630000114440918)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-substrate-selected resistant cell line S1-M1-80, SN-38 treatment, using 3 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 1346 nM (pChEMBL 5.869999885559082)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-substrate-selected resistant cell line S1-M1-80, SN-38 treatment, using 10 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 421 nM (pChEMBL 6.380000114440918)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-substrate-selected resistant cell line S1-M1-80, Topotecan treatment, using 0 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 2492 nM (pChEMBL 5.599999904632568)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-substrate-selected resistant cell line S1-M1-80, Topotecan treatment, using 3 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 1167 nM (pChEMBL 5.929999828338623)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-substrate-selected resistant cell line S1-M1-80, Topotecan treatment, using 10 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 168 nM (pChEMBL 6.78000020980835)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-substrate-selected resistant cell line S1-M1-80, Cisplatin treatment, using 0 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 1918 nM (pChEMBL 5.71999979019165)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-substrate-selected resistant cell line S1-M1-80, Cisplatin treatment, using 3 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 2169 nM (pChEMBL 5.659999847412109)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-substrate-selected resistant cell line S1-M1-80, Cisplatin treatment, using 10 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 2325 nM (pChEMBL 5.630000114440918)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/pcDNA3.1, Mitoxantrone treatment, using 0 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 32 nM (pChEMBL 7.5)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/pcDNA3.1, Mitoxantrone treatment, using 3 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 34 nM (pChEMBL 7.46999979019165)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/pcDNA3.1, Mitoxantrone treatment, using 10 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 38 nM (pChEMBL 7.420000076293945)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/pcDNA3.1, SN-38 treatment, using 0 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 21 nM (pChEMBL 7.679999828338623)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/pcDNA3.1, SN-38 treatment, using 3 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 18 nM (pChEMBL 7.75)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/pcDNA3.1, SN-38 treatment, using 10 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 26 nM (pChEMBL 7.579999923706055)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/pcDNA3.1, Topotecan treatment, using 0 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 44 nM (pChEMBL 7.360000133514404)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/pcDNA3.1, Topotecan treatment, using 3 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 46 nM (pChEMBL 7.340000152587891)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/pcDNA3.1, Topotecan treatment, using 10 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 42 nM (pChEMBL 7.380000114440918)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/pcDNA3.1, Cisplatin treatment, using 0 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 1230 nM (pChEMBL 5.909999847412109)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/pcDNA3.1, Cisplatin treatment, using 3 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 1170 nM (pChEMBL 5.929999828338623)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/pcDNA3.1, Cisplatin treatment, using 10 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 1385 nM (pChEMBL 5.860000133514404)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-R2, Mitoxantrone treatment, using 0 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 513 nM (pChEMBL 6.289999961853027)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-R2, Mitoxantrone treatment, using 3 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 299 nM (pChEMBL 6.519999980926514)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-R2, Mitoxantrone treatment, using 10 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 179 nM (pChEMBL 6.75)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-R2, SN-38 treatment, using 0 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 530 nM (pChEMBL 6.28000020980835)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-R2, SN-38 treatment, using 3 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 132 nM (pChEMBL 6.880000114440918)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-R2, SN-38 treatment, using 10 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 103 nM (pChEMBL 6.989999771118164)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-R2, Topotecan treatment, using 0 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 670 nM (pChEMBL 6.170000076293945)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-R2, Topotecan treatment, using 3 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 244 nM (pChEMBL 6.610000133514404)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-R2, Topotecan treatment, using 10 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 96 nM (pChEMBL 7.019999980926514)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-R2, Cisplatin treatment, using 0 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 1329 nM (pChEMBL 5.880000114440918)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-R2, Cisplatin treatment, using 3 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 1355 nM (pChEMBL 5.869999885559082)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-R2, Cisplatin treatment, using 10 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 1729 nM (pChEMBL 5.760000228881836)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-G2, Mitoxantrone treatment, using 0 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 693 nM (pChEMBL 6.159999847412109)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-G2, Mitoxantrone treatment, using 3 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 423 nM (pChEMBL 6.369999885559082)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-G2, Mitoxantrone treatment, using 10 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 43 nM (pChEMBL 7.369999885559082)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-G2, SN-38 treatment, using 0 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 477 nM (pChEMBL 6.320000171661377)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-G2, SN-38 treatment, using 3 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 266 nM (pChEMBL 6.579999923706055)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-G2, SN-38 treatment, using 10 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 57 nM (pChEMBL 7.239999771118164)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-G2, Topotecan treatment, using 0 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 617 nM (pChEMBL 6.210000038146973)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-G2, Topotecan treatment, using 3 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 283 nM (pChEMBL 6.550000190734863)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-G2, Topotecan treatment, using 10 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 31 nM (pChEMBL 7.510000228881836)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-G2, Cisplatin treatment, using 0 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 1367 nM (pChEMBL 5.860000133514404)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-G2, Cisplatin treatment, using 3 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 1613 nM (pChEMBL 5.789999961853027)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-G2, Cisplatin treatment, using 10 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 2064 nM (pChEMBL 5.679999828338623)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-T7, Mitoxantrone treatment, using 0 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 520 nM (pChEMBL 6.28000020980835)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-T7, Mitoxantrone treatment, using 3 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 310 nM (pChEMBL 6.510000228881836)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-T7, Mitoxantrone treatment, using 10 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 88 nM (pChEMBL 7.059999942779541)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-T7, SN-38 treatment, using 0 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 446 nM (pChEMBL 6.349999904632568)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-T7, SN-38 treatment, using 3 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 175 nM (pChEMBL 6.760000228881836)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-T7, SN-38 treatment, using 10 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 68 nM (pChEMBL 7.170000076293945)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-T7, Topotecan treatment, using 0 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 747 nM (pChEMBL 6.130000114440918)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-T7, Topotecan treatment, using 3 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 265 nM (pChEMBL 6.579999923706055)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-T7, Topotecan treatment, using 10 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 126 nM (pChEMBL 6.900000095367432)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-T7, Cisplatin treatment, using 0 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 1831 nM (pChEMBL 5.739999771118164)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-T7, Cisplatin treatment, using 3 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 1384 nM (pChEMBL 5.860000133514404)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCG2-gene-transfected cell line HEK293/ABCG2-482-T7, Cisplatin treatment, using 10 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 1773 nM (pChEMBL 5.75)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCC1-gene-transfected cell line KB-3-1, Vincristine treatment, using 0 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 11 nM (pChEMBL 7.960000038146973)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCC1-gene-transfected cell line KB-3-1, Vincristine treatment, using 3 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 16 nM (pChEMBL 7.800000190734863)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCC1-gene-transfected cell line KB-3-1, Vincristine treatment, using 10 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 14 nM (pChEMBL 7.849999904632568)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCC1-gene-transfected cell line KB-3-1, Cisplatin treatment, using 0 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 1681 nM (pChEMBL 5.769999980926514)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCC1-gene-transfected cell line KB-3-1, Cisplatin treatment, using 3 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 2332 nM (pChEMBL 5.630000114440918)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCC1-gene-transfected cell line KB-3-1, Cisplatin treatment, using 10 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 2138 nM (pChEMBL 5.670000076293945)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCC1-gene-transfected cell line KB-CV60, Vincristine treatment, using 0 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 217 nM (pChEMBL 6.659999847412109)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCC1-gene-transfected cell line KB-CV60, Vincristine treatment, using 3 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 195 nM (pChEMBL 6.710000038146973)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCC1-gene-transfected cell line KB-CV60, Vincristine treatment, using 10 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 234 nM (pChEMBL 6.630000114440918)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCC1-gene-transfected cell line KB-CV60, Cisplatin treatment, using 0 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 2421 nM (pChEMBL 5.619999885559082)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCC1-gene-transfected cell line KB-CV60, Cisplatin treatment, using 3 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 2232 nM (pChEMBL 5.650000095367432)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCC1-gene-transfected cell line KB-CV60, Cisplatin treatment, using 10 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 2392 nM (pChEMBL 5.619999885559082)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCC1-gene-transfected cell line HEK293/pcDNA3.1, Vincristine treatment, using 0 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 38 nM (pChEMBL 7.420000076293945)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCC1-gene-transfected cell line HEK293/pcDNA3.1, Vincristine treatment, using 3 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 33 nM (pChEMBL 7.480000019073486)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCC1-gene-transfected cell line HEK293/pcDNA3.1, Vincristine treatment, using 10 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 31 nM (pChEMBL 7.510000228881836)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCC1-gene-transfected cell line HEK293/pcDNA3.1, Cisplatin treatment, using 0 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 1343 nM (pChEMBL 5.869999885559082)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCC1-gene-transfected cell line HEK293/pcDNA3.1, Cisplatin treatment, using 3 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 1369 nM (pChEMBL 5.860000133514404)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCC1-gene-transfected cell line HEK293/pcDNA3.1, Cisplatin treatment, using 10 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 1279 nM (pChEMBL 5.889999866485596)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCC1-gene-transfected cell line HEK293/ABCC1, Vincristine treatment, using 0 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 356 nM (pChEMBL 6.449999809265137)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCC1-gene-transfected cell line HEK293/ABCC1, Vincristine treatment, using 3 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 341 nM (pChEMBL 6.46999979019165)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCC1-gene-transfected cell line HEK293/ABCC1, Vincristine treatment, using 10 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 369 nM (pChEMBL 6.429999828338623)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCC1-gene-transfected cell line HEK293/ABCC1, Cisplatin treatment, using 0 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 1646 nM (pChEMBL 5.78000020980835)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCC1-gene-transfected cell line HEK293/ABCC1, Cisplatin treatment, using 3 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 1554 nM (pChEMBL 5.809999942779541)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCC1-gene-transfected cell line HEK293/ABCC1, Cisplatin treatment, using 10 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 1474 nM (pChEMBL 5.829999923706055)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCC10-gene-transfected cell line HEK293/pcDNA3.1, Paclitaxel treatment, using 0 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 41 nM (pChEMBL 7.389999866485596)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCC10-gene-transfected cell line HEK293/pcDNA3.1, Paclitaxel treatment, using 3 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 43 nM (pChEMBL 7.369999885559082)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCC10-gene-transfected cell line HEK293/pcDNA3.1, Paclitaxel treatment, using 10 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 37 nM (pChEMBL 7.429999828338623)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCC10-gene-transfected cell line HEK293/pcDNA3.1, Cisplatin treatment, using 0 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 1042 nM (pChEMBL 5.980000019073486)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCC10-gene-transfected cell line HEK293/pcDNA3.1, Cisplatin treatment, using 3 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 1124 nM (pChEMBL 5.949999809265137)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47
Compound (SMILES): Cc1cc(F)c(C(=O)Nc2cccc(-c3nncn3C(C)C)n2)cc1-n1cnc(C2CC2)c1
InChIKey: YIDDLAAKOYYGJG-UHFFFAOYSA-N
Target: Mitogen-activated protein kinase kinase kinase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99683
Assay: Affinity Phenotypic Cellular interaction: (MTT assay (ABCC10-gene-transfected cell line HEK293/pcDNA3.1, Cisplatin treatment, using 10 uM Selonsertib)) EUB0000695a MAP3K5
Measurement: IC50 = 1132 nM (pChEMBL 5.949999809265137)
Descriptors: MW 445.5, ALogP 4.68, HBA 7, HBD 1, PSA 90.52, QED 0.47