lovingscience/chembl-v37-raw-activities huggingface dataset:
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: DnaJ homolog subfamily C member 10 (SINGLE PROTEIN), Homo sapiens
UniProt: Q8IXB1
Assay: Binding affinity to human DNAJC10 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 4928535.83 nM (pChEMBL 2.309999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Dynamin-2 (SINGLE PROTEIN), Homo sapiens
UniProt: P50570
Assay: Binding affinity to human DNM2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 21874.46 nM (pChEMBL 4.659999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Dynamin-2 (SINGLE PROTEIN), Homo sapiens
UniProt: P50570
Assay: Binding affinity to human DNM2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 21874.46 nM (pChEMBL 4.659999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Dolichol-phosphate mannosyltransferase subunit 1 (SINGLE PROTEIN), Homo sapiens
UniProt: O60762
Assay: Binding affinity to human DPM1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 38996.03 nM (pChEMBL 4.409999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Dolichol-phosphate mannosyltransferase subunit 1 (SINGLE PROTEIN), Homo sapiens
UniProt: O60762
Assay: Binding affinity to human DPM1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 38996.03 nM (pChEMBL 4.409999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Dipeptidyl peptidase 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UHL4
Assay: Binding affinity to human DPP7 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 5.288 nM (pChEMBL 8.279999732971191)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Dipeptidyl peptidase 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UHL4
Assay: Binding affinity to human DPP7 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 5.288 nM (pChEMBL 8.279999732971191)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Dihydropyrimidinase-related protein 3 (SINGLE PROTEIN), Homo sapiens
UniProt: Q14195
Assay: Binding affinity to human DPYSL3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 358.95 nM (pChEMBL 6.449999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Dihydropyrimidinase-related protein 3 (SINGLE PROTEIN), Homo sapiens
UniProt: Q14195
Assay: Binding affinity to human DPYSL3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 378.85 nM (pChEMBL 6.420000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Desmoplakin (SINGLE PROTEIN), Homo sapiens
UniProt: P15924
Assay: Binding affinity to human DSP incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 22316.66 nM (pChEMBL 4.650000095367432)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Desmoplakin (SINGLE PROTEIN), Homo sapiens
UniProt: P15924
Assay: Binding affinity to human DSP incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 22316.66 nM (pChEMBL 4.650000095367432)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Cytoplasmic dynein 1 heavy chain 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q14204
Assay: Binding affinity to human DYNC1H1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1301.55 nM (pChEMBL 5.889999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Cytoplasmic dynein 1 heavy chain 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q14204
Assay: Binding affinity to human DYNC1H1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1301.55 nM (pChEMBL 5.889999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Cytoplasmic dynein 1 light intermediate chain 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y6G9
Assay: Binding affinity to human DYNC1LI1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 24.35 nM (pChEMBL 7.610000133514404)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Cytoplasmic dynein 1 light intermediate chain 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y6G9
Assay: Binding affinity to human DYNC1LI1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 24.35 nM (pChEMBL 7.610000133514404)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Dynein light chain 1, cytoplasmic (SINGLE PROTEIN), Homo sapiens
UniProt: P63167
Assay: Binding affinity to human DYNLL1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 7.748 nM (pChEMBL 8.109999656677246)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Dynein light chain 1, cytoplasmic (SINGLE PROTEIN), Homo sapiens
UniProt: P63167
Assay: Binding affinity to human DYNLL1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 15.47 nM (pChEMBL 7.809999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Dynein light chain 2, cytoplasmic (SINGLE PROTEIN), Homo sapiens
UniProt: Q96FJ2
Assay: Binding affinity to human DYNLL2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 80.89 nM (pChEMBL 7.090000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Dynein light chain 2, cytoplasmic (SINGLE PROTEIN), Homo sapiens
UniProt: Q96FJ2
Assay: Binding affinity to human DYNLL2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 148.04 nM (pChEMBL 6.829999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Dual specificity tyrosine-phosphorylation-regulated kinase 1A (SINGLE PROTEIN), Homo sapiens
UniProt: Q13627
Assay: Binding affinity to human DYRK1A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 95.25 nM (pChEMBL 7.019999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Dual specificity tyrosine-phosphorylation-regulated kinase 1A (SINGLE PROTEIN), Homo sapiens
UniProt: Q13627
Assay: Binding affinity to human DYRK1A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 102.08 nM (pChEMBL 6.989999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Probable rRNA-processing protein EBP2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99848
Assay: Binding affinity to human EBNA1BP2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 298.86 nM (pChEMBL 6.53000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Probable rRNA-processing protein EBP2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99848
Assay: Binding affinity to human EBNA1BP2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 298.86 nM (pChEMBL 6.53000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (SINGLE PROTEIN), Homo sapiens
UniProt: Q15125
Assay: Binding affinity to human EBP incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 14.79 nM (pChEMBL 7.829999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: 3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (SINGLE PROTEIN), Homo sapiens
UniProt: Q15125
Assay: Binding affinity to human EBP incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 14.79 nM (pChEMBL 7.829999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Enoyl-CoA delta isomerase 1, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: P42126
Assay: Binding affinity to human ECI1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 5015.08 nM (pChEMBL 5.300000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Enoyl-CoA delta isomerase 1, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: P42126
Assay: Binding affinity to human ECI1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 5015.08 nM (pChEMBL 5.300000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Proteasome adapter and scaffold protein ECM29 (SINGLE PROTEIN), Homo sapiens
UniProt: Q5VYK3
Assay: Binding affinity to human ECM29 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 11032.55 nM (pChEMBL 4.960000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Proteasome adapter and scaffold protein ECM29 (SINGLE PROTEIN), Homo sapiens
UniProt: Q5VYK3
Assay: Binding affinity to human ECM29 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 11032.55 nM (pChEMBL 4.960000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Elongation factor 1-delta (SINGLE PROTEIN), Homo sapiens
UniProt: P29692
Assay: Binding affinity to human EEF1D incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1737.36 nM (pChEMBL 5.760000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Elongation factor 1-delta (SINGLE PROTEIN), Homo sapiens
UniProt: P29692
Assay: Binding affinity to human EEF1D incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1737.36 nM (pChEMBL 5.760000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Eukaryotic translation elongation factor 1 epsilon-1 (SINGLE PROTEIN), Homo sapiens
UniProt: O43324
Assay: Binding affinity to human EEF1E1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 167.84 nM (pChEMBL 6.78000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Eukaryotic translation elongation factor 1 epsilon-1 (SINGLE PROTEIN), Homo sapiens
UniProt: O43324
Assay: Binding affinity to human EEF1E1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 167.84 nM (pChEMBL 6.78000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Elongation factor 1-gamma (SINGLE PROTEIN), Homo sapiens
UniProt: P26641
Assay: Binding affinity to human EEF1G incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 11.42 nM (pChEMBL 7.940000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Elongation factor 1-gamma (SINGLE PROTEIN), Homo sapiens
UniProt: P26641
Assay: Binding affinity to human EEF1G incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 11.42 nM (pChEMBL 7.940000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Elongation factor 2 (SINGLE PROTEIN), Homo sapiens
UniProt: P13639
Assay: Binding affinity to human EEF2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 4031.84 nM (pChEMBL 5.389999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Elongation factor 2 (SINGLE PROTEIN), Homo sapiens
UniProt: P13639
Assay: Binding affinity to human EEF2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 4031.84 nM (pChEMBL 5.389999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: 116 kDa U5 small nuclear ribonucleoprotein component (SINGLE PROTEIN), Homo sapiens
UniProt: Q15029
Assay: Binding affinity to human EFTUD2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 108.19 nM (pChEMBL 6.96999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: 116 kDa U5 small nuclear ribonucleoprotein component (SINGLE PROTEIN), Homo sapiens
UniProt: Q15029
Assay: Binding affinity to human EFTUD2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 108.19 nM (pChEMBL 6.96999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Epidermal growth factor receptor (SINGLE PROTEIN), Homo sapiens
UniProt: P00533
Assay: Binding affinity to human EGFR incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 90.3 nM (pChEMBL 7.039999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Epidermal growth factor receptor (SINGLE PROTEIN), Homo sapiens
UniProt: P00533
Assay: Binding affinity to human EGFR incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 113.87 nM (pChEMBL 6.940000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Eukaryotic translation initiation factor 2A (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BY44
Assay: Binding affinity to human EIF2A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 23316.26 nM (pChEMBL 4.630000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Eukaryotic translation initiation factor 2A (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BY44
Assay: Binding affinity to human EIF2A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 25676.98 nM (pChEMBL 4.590000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Eukaryotic translation initiation factor 2-alpha kinase 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BQI3
Assay: Binding affinity to human EIF2AK1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 23611.49 nM (pChEMBL 4.630000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Eukaryotic translation initiation factor 2-alpha kinase 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BQI3
Assay: Binding affinity to human EIF2AK1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 25622.35 nM (pChEMBL 4.590000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Translation initiation factor eIF2B subunit gamma (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NR50
Assay: Binding affinity to human EIF2B3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 10185.19 nM (pChEMBL 4.989999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Translation initiation factor eIF2B subunit gamma (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NR50
Assay: Binding affinity to human EIF2B3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 10254.86 nM (pChEMBL 4.989999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Translation initiation factor eIF2B subunit delta (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UI10
Assay: Binding affinity to human EIF2B4 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 9564.5 nM (pChEMBL 5.019999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Translation initiation factor eIF2B subunit delta (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UI10
Assay: Binding affinity to human EIF2B4 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 9564.5 nM (pChEMBL 5.019999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Eukaryotic initiation factor 4A-I (SINGLE PROTEIN), Homo sapiens
UniProt: P60842
Assay: Binding affinity to human EIF4A1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 24.14 nM (pChEMBL 7.619999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Eukaryotic initiation factor 4A-I (SINGLE PROTEIN), Homo sapiens
UniProt: P60842
Assay: Binding affinity to human EIF4A1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 24.14 nM (pChEMBL 7.619999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Eukaryotic translation initiation factor 4B (SINGLE PROTEIN), Homo sapiens
UniProt: P23588
Assay: Binding affinity to human EIF4B incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 449.04 nM (pChEMBL 6.349999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Eukaryotic translation initiation factor 4B (SINGLE PROTEIN), Homo sapiens
UniProt: P23588
Assay: Binding affinity to human EIF4B incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 449.04 nM (pChEMBL 6.349999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Eukaryotic translation initiation factor 4 gamma 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q04637
Assay: Binding affinity to human EIF4G1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 23.81 nM (pChEMBL 7.619999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Eukaryotic translation initiation factor 4 gamma 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q04637
Assay: Binding affinity to human EIF4G1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 23.81 nM (pChEMBL 7.619999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Eukaryotic translation initiation factor 4H (SINGLE PROTEIN), Homo sapiens
UniProt: Q15056
Assay: Binding affinity to human EIF4H incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 90615.22 nM (pChEMBL 4.039999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Eukaryotic translation initiation factor 4H (SINGLE PROTEIN), Homo sapiens
UniProt: Q15056
Assay: Binding affinity to human EIF4H incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 90615.22 nM (pChEMBL 4.039999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Eukaryotic translation initiation factor 5B (SINGLE PROTEIN), Homo sapiens
UniProt: O60841
Assay: Binding affinity to human EIF5B incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 41819.27 nM (pChEMBL 4.380000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Eukaryotic translation initiation factor 5B (SINGLE PROTEIN), Homo sapiens
UniProt: O60841
Assay: Binding affinity to human EIF5B incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 41819.27 nM (pChEMBL 4.380000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Eukaryotic translation initiation factor 6 (SINGLE PROTEIN), Homo sapiens
UniProt: P56537
Assay: Binding affinity to human EIF6 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2999.42 nM (pChEMBL 5.519999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Eukaryotic translation initiation factor 6 (SINGLE PROTEIN), Homo sapiens
UniProt: P56537
Assay: Binding affinity to human EIF6 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2999.42 nM (pChEMBL 5.519999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: ELAV-like protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q15717
Assay: Binding affinity to human ELAVL1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 10.69 nM (pChEMBL 7.96999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: ELAV-like protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q15717
Assay: Binding affinity to human ELAVL1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 10.69 nM (pChEMBL 7.96999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Very long chain fatty acid elongase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NYP7
Assay: Binding affinity to human ELOVL5 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2869.08 nM (pChEMBL 5.539999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Very long chain fatty acid elongase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NYP7
Assay: Binding affinity to human ELOVL5 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2869.08 nM (pChEMBL 5.539999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Emerin (SINGLE PROTEIN), Homo sapiens
UniProt: P50402
Assay: Binding affinity to human EMD incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 45503.25 nM (pChEMBL 4.340000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Emerin (SINGLE PROTEIN), Homo sapiens
UniProt: P50402
Assay: Binding affinity to human EMD incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 45503.25 nM (pChEMBL 4.340000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Alpha-enolase (SINGLE PROTEIN), Homo sapiens
UniProt: P06733
Assay: Binding affinity to human ENO1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 4367.75 nM (pChEMBL 5.360000133514404)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Alpha-enolase (SINGLE PROTEIN), Homo sapiens
UniProt: P06733
Assay: Binding affinity to human ENO1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 4367.75 nM (pChEMBL 5.360000133514404)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Band 4.1-like protein 2 (SINGLE PROTEIN), Homo sapiens
UniProt: O43491
Assay: Binding affinity to human EPB41L2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 5.411 nM (pChEMBL 8.270000457763672)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Band 4.1-like protein 2 (SINGLE PROTEIN), Homo sapiens
UniProt: O43491
Assay: Binding affinity to human EPB41L2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 5.411 nM (pChEMBL 8.270000457763672)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Mammalian ependymin-related protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UM22
Assay: Binding affinity to human EPDR1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 259.88 nM (pChEMBL 6.579999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Mammalian ependymin-related protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UM22
Assay: Binding affinity to human EPDR1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 361.9 nM (pChEMBL 6.440000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Bifunctional glutamate/proline--tRNA ligase (SINGLE PROTEIN), Homo sapiens
UniProt: P07814
Assay: Binding affinity to human EPRS incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 32.41 nM (pChEMBL 7.489999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Bifunctional glutamate/proline--tRNA ligase (SINGLE PROTEIN), Homo sapiens
UniProt: P07814
Assay: Binding affinity to human EPRS incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 32.41 nM (pChEMBL 7.489999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ethanolaminephosphotransferase 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9C0D9
Assay: Binding affinity to human EPT1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1535.33 nM (pChEMBL 5.809999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ethanolaminephosphotransferase 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9C0D9
Assay: Binding affinity to human EPT1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1535.33 nM (pChEMBL 5.809999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Endoplasmic reticulum aminopeptidase 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NZ08
Assay: Binding affinity to human ERAP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 6216.64 nM (pChEMBL 5.210000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Endoplasmic reticulum aminopeptidase 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NZ08
Assay: Binding affinity to human ERAP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 6216.64 nM (pChEMBL 5.210000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: General transcription and DNA repair factor IIH helicase subunit XPD (SINGLE PROTEIN), Homo sapiens
UniProt: P18074
Assay: Binding affinity to human ERCC2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 179.7 nM (pChEMBL 6.75)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: General transcription and DNA repair factor IIH helicase subunit XPD (SINGLE PROTEIN), Homo sapiens
UniProt: P18074
Assay: Binding affinity to human ERCC2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 198.62 nM (pChEMBL 6.699999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Enhancer of rudimentary homolog (SINGLE PROTEIN), Homo sapiens
UniProt: P84090
Assay: Binding affinity to human ERH incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 8.954 nM (pChEMBL 8.050000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Enhancer of rudimentary homolog (SINGLE PROTEIN), Homo sapiens
UniProt: P84090
Assay: Binding affinity to human ERH incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 8.954 nM (pChEMBL 8.050000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Erlin-1 (SINGLE PROTEIN), Homo sapiens
UniProt: O75477
Assay: Binding affinity to human ERLIN1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 367.08 nM (pChEMBL 6.429999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Erlin-1 (SINGLE PROTEIN), Homo sapiens
UniProt: O75477
Assay: Binding affinity to human ERLIN1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 367.08 nM (pChEMBL 6.429999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Erlin-2 (SINGLE PROTEIN), Homo sapiens
UniProt: O94905
Assay: Binding affinity to human ERLIN2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 32457.72 nM (pChEMBL 4.489999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Erlin-2 (SINGLE PROTEIN), Homo sapiens
UniProt: O94905
Assay: Binding affinity to human ERLIN2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 32457.72 nM (pChEMBL 4.489999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase/endoribonuclease IRE1 (SINGLE PROTEIN), Homo sapiens
UniProt: O75460
Assay: Binding affinity to human ERN1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 4.309 nM (pChEMBL 8.369999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase/endoribonuclease IRE1 (SINGLE PROTEIN), Homo sapiens
UniProt: O75460
Assay: Binding affinity to human ERN1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 5.288 nM (pChEMBL 8.279999732971191)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase/endoribonuclease IRE2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q76MJ5
Assay: Binding affinity to human ERN2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2111.87 nM (pChEMBL 5.670000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase/endoribonuclease IRE2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q76MJ5
Assay: Binding affinity to human ERN2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2695.83 nM (pChEMBL 5.570000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Extended synaptotagmin-1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BSJ8
Assay: Binding affinity to human ESYT1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 9.367 nM (pChEMBL 8.029999732971191)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Extended synaptotagmin-1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BSJ8
Assay: Binding affinity to human ESYT1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 9.367 nM (pChEMBL 8.029999732971191)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Extended synaptotagmin-2 (SINGLE PROTEIN), Homo sapiens
UniProt: A0FGR8
Assay: Binding affinity to human ESYT2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 40.99 nM (pChEMBL 7.389999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Extended synaptotagmin-2 (SINGLE PROTEIN), Homo sapiens
UniProt: A0FGR8
Assay: Binding affinity to human ESYT2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 40.99 nM (pChEMBL 7.389999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: RNA-binding protein EWS (SINGLE PROTEIN), Homo sapiens
UniProt: Q01844
Assay: Binding affinity to human EWSR1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 54102.44 nM (pChEMBL 4.269999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: RNA-binding protein EWS (SINGLE PROTEIN), Homo sapiens
UniProt: Q01844
Assay: Binding affinity to human EWSR1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 54102.44 nM (pChEMBL 4.269999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Exocyst complex component 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NV70
Assay: Binding affinity to human EXOC1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 11.15 nM (pChEMBL 7.949999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Exocyst complex component 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NV70
Assay: Binding affinity to human EXOC1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 11.15 nM (pChEMBL 7.949999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Exocyst complex component 4 (SINGLE PROTEIN), Homo sapiens
UniProt: Q96A65
Assay: Binding affinity to human EXOC4 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 11361.06 nM (pChEMBL 4.949999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Exocyst complex component 4 (SINGLE PROTEIN), Homo sapiens
UniProt: Q96A65
Assay: Binding affinity to human EXOC4 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 11361.06 nM (pChEMBL 4.949999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Exosome complex component 10 (SINGLE PROTEIN), Homo sapiens
UniProt: Q01780
Assay: Binding affinity to human EXOSC10 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 3.702 nM (pChEMBL 8.430000305175781)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Exosome complex component 10 (SINGLE PROTEIN), Homo sapiens
UniProt: Q01780
Assay: Binding affinity to human EXOSC10 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 3.702 nM (pChEMBL 8.430000305175781)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ezrin (SINGLE PROTEIN), Homo sapiens
UniProt: P15311
Assay: Binding affinity to human EZR incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 7289.59 nM (pChEMBL 5.139999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ezrin (SINGLE PROTEIN), Homo sapiens
UniProt: P15311
Assay: Binding affinity to human EZR incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 7289.59 nM (pChEMBL 5.139999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Constitutive coactivator of PPAR-gamma-like protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NZB2
Assay: Binding affinity to human FAM120A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 4664.72 nM (pChEMBL 5.329999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Constitutive coactivator of PPAR-gamma-like protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NZB2
Assay: Binding affinity to human FAM120A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 4664.72 nM (pChEMBL 5.329999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Protein FAM136A (SINGLE PROTEIN), Homo sapiens
UniProt: Q96C01
Assay: Binding affinity to human FAM136A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 31.19 nM (pChEMBL 7.510000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Protein FAM136A (SINGLE PROTEIN), Homo sapiens
UniProt: Q96C01
Assay: Binding affinity to human FAM136A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 42.95 nM (pChEMBL 7.369999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: CYFIP-related Rac1 interactor B (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NUQ9
Assay: Binding affinity to human FAM49B incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 4848.64 nM (pChEMBL 5.309999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: CYFIP-related Rac1 interactor B (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NUQ9
Assay: Binding affinity to human FAM49B incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 4848.64 nM (pChEMBL 5.309999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Protein FAM83B (SINGLE PROTEIN), Homo sapiens
UniProt: Q5T0W9
Assay: Binding affinity to human FAM83B incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1377374.48 nM (pChEMBL 2.859999895095825)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Protein FAM83E (SINGLE PROTEIN), Homo sapiens
UniProt: Q2M2I3
Assay: Binding affinity to human FAM83E incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 112.07 nM (pChEMBL 6.949999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32