lovingscience/chembl-v37-raw-activities huggingface dataset:
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Ethanolaminephosphotransferase 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9C0D9
Assay: Binding affinity to human EPT1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 809.16 nM (pChEMBL 6.090000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: GTPase Era, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: O75616
Assay: Binding affinity to human ERAL1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 69.7 nM (pChEMBL 7.159999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: GTPase Era, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: O75616
Assay: Binding affinity to human ERAL1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 69.7 nM (pChEMBL 7.159999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Endoplasmic reticulum aminopeptidase 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NZ08
Assay: Binding affinity to human ERAP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 8490.89 nM (pChEMBL 5.070000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Endoplasmic reticulum aminopeptidase 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NZ08
Assay: Binding affinity to human ERAP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 8490.89 nM (pChEMBL 5.070000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: General transcription and DNA repair factor IIH helicase subunit XPD (SINGLE PROTEIN), Homo sapiens
UniProt: P18074
Assay: Binding affinity to human ERCC2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 19682.96 nM (pChEMBL 4.710000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: General transcription and DNA repair factor IIH helicase subunit XPD (SINGLE PROTEIN), Homo sapiens
UniProt: P18074
Assay: Binding affinity to human ERCC2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 21755.72 nM (pChEMBL 4.659999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Endoplasmic reticulum-Golgi intermediate compartment protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q969X5
Assay: Binding affinity to human ERGIC1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 10649.56 nM (pChEMBL 4.96999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Endoplasmic reticulum-Golgi intermediate compartment protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q969X5
Assay: Binding affinity to human ERGIC1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 10649.56 nM (pChEMBL 4.96999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Enhancer of rudimentary homolog (SINGLE PROTEIN), Homo sapiens
UniProt: P84090
Assay: Binding affinity to human ERH incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 806.46 nM (pChEMBL 6.090000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Enhancer of rudimentary homolog (SINGLE PROTEIN), Homo sapiens
UniProt: P84090
Assay: Binding affinity to human ERH incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 806.46 nM (pChEMBL 6.090000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Erlin-1 (SINGLE PROTEIN), Homo sapiens
UniProt: O75477
Assay: Binding affinity to human ERLIN1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 4.42 nM (pChEMBL 8.359999656677246)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Erlin-1 (SINGLE PROTEIN), Homo sapiens
UniProt: O75477
Assay: Binding affinity to human ERLIN1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 4.42 nM (pChEMBL 8.359999656677246)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Erlin-2 (SINGLE PROTEIN), Homo sapiens
UniProt: O94905
Assay: Binding affinity to human ERLIN2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 3055.29 nM (pChEMBL 5.510000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Erlin-2 (SINGLE PROTEIN), Homo sapiens
UniProt: O94905
Assay: Binding affinity to human ERLIN2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 3055.29 nM (pChEMBL 5.510000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Endoplasmic reticulum metallopeptidase 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q7Z2K6
Assay: Binding affinity to human ERMP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 3993.45 nM (pChEMBL 5.400000095367432)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Endoplasmic reticulum metallopeptidase 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q7Z2K6
Assay: Binding affinity to human ERMP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 4552.73 nM (pChEMBL 5.340000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase/endoribonuclease IRE1 (SINGLE PROTEIN), Homo sapiens
UniProt: O75460
Assay: Binding affinity to human ERN1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1563.04 nM (pChEMBL 5.809999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase/endoribonuclease IRE1 (SINGLE PROTEIN), Homo sapiens
UniProt: O75460
Assay: Binding affinity to human ERN1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1918.03 nM (pChEMBL 5.71999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase/endoribonuclease IRE2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q76MJ5
Assay: Binding affinity to human ERN2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1337.43 nM (pChEMBL 5.869999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase/endoribonuclease IRE2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q76MJ5
Assay: Binding affinity to human ERN2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1707.25 nM (pChEMBL 5.769999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: ERO1-like protein alpha (SINGLE PROTEIN), Homo sapiens
UniProt: Q96HE7
Assay: Binding affinity to human ERO1L incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 330.1 nM (pChEMBL 6.480000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: ERO1-like protein alpha (SINGLE PROTEIN), Homo sapiens
UniProt: Q96HE7
Assay: Binding affinity to human ERO1L incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 330.1 nM (pChEMBL 6.480000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Endoplasmic reticulum resident protein 29 (SINGLE PROTEIN), Homo sapiens
UniProt: P30040
Assay: Binding affinity to human ERP29 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 59.14 nM (pChEMBL 7.230000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Endoplasmic reticulum resident protein 29 (SINGLE PROTEIN), Homo sapiens
UniProt: P30040
Assay: Binding affinity to human ERP29 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 59.14 nM (pChEMBL 7.230000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Endoplasmic reticulum resident protein 44 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BS26
Assay: Binding affinity to human ERP44 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 20131.83 nM (pChEMBL 4.699999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Endoplasmic reticulum resident protein 44 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BS26
Assay: Binding affinity to human ERP44 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 20131.83 nM (pChEMBL 4.699999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: S-formylglutathione hydrolase (SINGLE PROTEIN), Homo sapiens
UniProt: P10768
Assay: Binding affinity to human ESD incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 116.45 nM (pChEMBL 6.929999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: S-formylglutathione hydrolase (SINGLE PROTEIN), Homo sapiens
UniProt: P10768
Assay: Binding affinity to human ESD incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 116.45 nM (pChEMBL 6.929999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Extended synaptotagmin-1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BSJ8
Assay: Binding affinity to human ESYT1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 6849848.9 nM (pChEMBL 2.1600000858306885)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Extended synaptotagmin-2 (SINGLE PROTEIN), Homo sapiens
UniProt: A0FGR8
Assay: Binding affinity to human ESYT2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 28.59 nM (pChEMBL 7.539999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Extended synaptotagmin-2 (SINGLE PROTEIN), Homo sapiens
UniProt: A0FGR8
Assay: Binding affinity to human ESYT2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 28.59 nM (pChEMBL 7.539999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Eukaryotic peptide chain release factor subunit 1 (SINGLE PROTEIN), Homo sapiens
UniProt: P62495
Assay: Binding affinity to human ETF1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 484072.89 nM (pChEMBL 3.309999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Electron transfer flavoprotein subunit alpha, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: P13804
Assay: Binding affinity to human ETFA incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 92.8 nM (pChEMBL 7.03000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Electron transfer flavoprotein subunit alpha, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: P13804
Assay: Binding affinity to human ETFA incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 92.8 nM (pChEMBL 7.03000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Electron transfer flavoprotein subunit beta (SINGLE PROTEIN), Homo sapiens
UniProt: P38117
Assay: Binding affinity to human ETFB incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 16604.05 nM (pChEMBL 4.78000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Electron transfer flavoprotein subunit beta (SINGLE PROTEIN), Homo sapiens
UniProt: P38117
Assay: Binding affinity to human ETFB incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 16604.05 nM (pChEMBL 4.78000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: RNA-binding protein EWS (SINGLE PROTEIN), Homo sapiens
UniProt: Q01844
Assay: Binding affinity to human EWSR1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 11787.99 nM (pChEMBL 4.929999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: RNA-binding protein EWS (SINGLE PROTEIN), Homo sapiens
UniProt: Q01844
Assay: Binding affinity to human EWSR1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 11787.99 nM (pChEMBL 4.929999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Exocyst complex component 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NV70
Assay: Binding affinity to human EXOC1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 79.37 nM (pChEMBL 7.099999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Exocyst complex component 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NV70
Assay: Binding affinity to human EXOC1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 79.37 nM (pChEMBL 7.099999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Exocyst complex component 3 (SINGLE PROTEIN), Homo sapiens
UniProt: O60645
Assay: Binding affinity to human EXOC3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 31.99 nM (pChEMBL 7.5)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Exocyst complex component 3 (SINGLE PROTEIN), Homo sapiens
UniProt: O60645
Assay: Binding affinity to human EXOC3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 31.99 nM (pChEMBL 7.5)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Exocyst complex component 4 (SINGLE PROTEIN), Homo sapiens
UniProt: Q96A65
Assay: Binding affinity to human EXOC4 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 48.76 nM (pChEMBL 7.309999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Exocyst complex component 4 (SINGLE PROTEIN), Homo sapiens
UniProt: Q96A65
Assay: Binding affinity to human EXOC4 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 48.76 nM (pChEMBL 7.309999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Exosome complex component 10 (SINGLE PROTEIN), Homo sapiens
UniProt: Q01780
Assay: Binding affinity to human EXOSC10 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 347823.6 nM (pChEMBL 3.4600000381469727)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Exosome complex component RRP41 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NPD3
Assay: Binding affinity to human EXOSC4 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1268.43 nM (pChEMBL 5.900000095367432)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Exosome complex component RRP41 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NPD3
Assay: Binding affinity to human EXOSC4 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1268.43 nM (pChEMBL 5.900000095367432)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Exosome complex component RRP46 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NQT4
Assay: Binding affinity to human EXOSC5 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 18047.55 nM (pChEMBL 4.739999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Exosome complex component RRP46 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NQT4
Assay: Binding affinity to human EXOSC5 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 20101.1 nM (pChEMBL 4.699999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Exosome complex component RRP45 (SINGLE PROTEIN), Homo sapiens
UniProt: Q06265
Assay: Binding affinity to human EXOSC9 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2291.73 nM (pChEMBL 5.639999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Exosome complex component RRP45 (SINGLE PROTEIN), Homo sapiens
UniProt: Q06265
Assay: Binding affinity to human EXOSC9 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 3107.55 nM (pChEMBL 5.510000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Ezrin (SINGLE PROTEIN), Homo sapiens
UniProt: P15311
Assay: Binding affinity to human EZR incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 82.71 nM (pChEMBL 7.079999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Ezrin (SINGLE PROTEIN), Homo sapiens
UniProt: P15311
Assay: Binding affinity to human EZR incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 82.71 nM (pChEMBL 7.079999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Fatty acid-binding protein 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q01469
Assay: Binding affinity to human FABP5 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 359 nM (pChEMBL 6.449999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Fatty acid-binding protein 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q01469
Assay: Binding affinity to human FABP5 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 359 nM (pChEMBL 6.449999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Acyl-CoA 6-desaturase (SINGLE PROTEIN), Homo sapiens
UniProt: O95864
Assay: Binding affinity to human FADS2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 407.65 nM (pChEMBL 6.389999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Acyl-CoA 6-desaturase (SINGLE PROTEIN), Homo sapiens
UniProt: O95864
Assay: Binding affinity to human FADS2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 407.65 nM (pChEMBL 6.389999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Fumarylacetoacetase (SINGLE PROTEIN), Homo sapiens
UniProt: P16930
Assay: Binding affinity to human FAH incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 27.49 nM (pChEMBL 7.559999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Fumarylacetoacetase (SINGLE PROTEIN), Homo sapiens
UniProt: P16930
Assay: Binding affinity to human FAH incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 27.49 nM (pChEMBL 7.559999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Constitutive coactivator of PPAR-gamma-like protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NZB2
Assay: Binding affinity to human FAM120A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 3.652 nM (pChEMBL 8.4399995803833)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Constitutive coactivator of PPAR-gamma-like protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NZB2
Assay: Binding affinity to human FAM120A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 3.652 nM (pChEMBL 8.4399995803833)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein Niban 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q96TA1
Assay: Binding affinity to human FAM129B incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 42263.93 nM (pChEMBL 4.369999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein Niban 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q96TA1
Assay: Binding affinity to human FAM129B incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 42263.93 nM (pChEMBL 4.369999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein FAM136A (SINGLE PROTEIN), Homo sapiens
UniProt: Q96C01
Assay: Binding affinity to human FAM136A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 3363.72 nM (pChEMBL 5.46999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein FAM136A (SINGLE PROTEIN), Homo sapiens
UniProt: Q96C01
Assay: Binding affinity to human FAM136A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 4630.93 nM (pChEMBL 5.329999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein FAM162A (SINGLE PROTEIN), Homo sapiens
UniProt: Q96A26
Assay: Binding affinity to human FAM162A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 14826.87 nM (pChEMBL 4.829999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein FAM162A (SINGLE PROTEIN), Homo sapiens
UniProt: Q96A26
Assay: Binding affinity to human FAM162A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 14826.87 nM (pChEMBL 4.829999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein FAM222B (SINGLE PROTEIN), Homo sapiens
UniProt: Q8WU58
Assay: Binding affinity to human FAM222B incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 110.36 nM (pChEMBL 6.960000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein FAM222B (SINGLE PROTEIN), Homo sapiens
UniProt: Q8WU58
Assay: Binding affinity to human FAM222B incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 180.85 nM (pChEMBL 6.739999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: CYFIP-related Rac1 interactor B (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NUQ9
Assay: Binding affinity to human FAM49B incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 42953.14 nM (pChEMBL 4.369999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: CYFIP-related Rac1 interactor B (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NUQ9
Assay: Binding affinity to human FAM49B incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 42953.14 nM (pChEMBL 4.369999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein FAM83A (SINGLE PROTEIN), Homo sapiens
UniProt: Q86UY5
Assay: Binding affinity to human FAM83A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 15.36 nM (pChEMBL 7.809999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein FAM83A (SINGLE PROTEIN), Homo sapiens
UniProt: Q86UY5
Assay: Binding affinity to human FAM83A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 17.43 nM (pChEMBL 7.760000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein FAM83B (SINGLE PROTEIN), Homo sapiens
UniProt: Q5T0W9
Assay: Binding affinity to human FAM83B incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 253.72 nM (pChEMBL 6.599999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein FAM83B (SINGLE PROTEIN), Homo sapiens
UniProt: Q5T0W9
Assay: Binding affinity to human FAM83B incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 253.72 nM (pChEMBL 6.599999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein FAM83E (SINGLE PROTEIN), Homo sapiens
UniProt: Q2M2I3
Assay: Binding affinity to human FAM83E incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 155160.72 nM (pChEMBL 3.809999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Fanconi anemia group D2 protein (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BXW9
Assay: Binding affinity to human FANCD2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2278.36 nM (pChEMBL 5.639999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Fanconi anemia group D2 protein (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BXW9
Assay: Binding affinity to human FANCD2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2278.36 nM (pChEMBL 5.639999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Fanconi anemia group I protein (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NVI1
Assay: Binding affinity to human FANCI incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2126.75 nM (pChEMBL 5.670000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Fanconi anemia group I protein (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NVI1
Assay: Binding affinity to human FANCI incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2202.89 nM (pChEMBL 5.659999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Fatty acyl-CoA reductase 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q8WVX9
Assay: Binding affinity to human FAR1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 113155.28 nM (pChEMBL 3.950000047683716)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Phenylalanine--tRNA ligase alpha subunit (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y285
Assay: Binding affinity to human FARSA incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 80.11 nM (pChEMBL 7.099999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Phenylalanine--tRNA ligase alpha subunit (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y285
Assay: Binding affinity to human FARSA incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 80.11 nM (pChEMBL 7.099999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Fatty acid synthase (SINGLE PROTEIN), Homo sapiens
UniProt: P49327
Assay: Binding affinity to human FASN incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 106.92 nM (pChEMBL 6.96999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Fatty acid synthase (SINGLE PROTEIN), Homo sapiens
UniProt: P49327
Assay: Binding affinity to human FASN incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 106.92 nM (pChEMBL 6.96999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: FAST kinase domain-containing protein 1, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: Q53R41
Assay: Binding affinity to human FASTKD1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 169.65 nM (pChEMBL 6.769999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: FAST kinase domain-containing protein 1, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: Q53R41
Assay: Binding affinity to human FASTKD1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 169.65 nM (pChEMBL 6.769999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: FAST kinase domain-containing protein 5, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: Q7L8L6
Assay: Binding affinity to human FASTKD5 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 314.92 nM (pChEMBL 6.5)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: FAST kinase domain-containing protein 5, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: Q7L8L6
Assay: Binding affinity to human FASTKD5 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 314.92 nM (pChEMBL 6.5)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein (SINGLE PROTEIN), Homo sapiens
UniProt: P62861
Assay: Binding affinity to human FAU incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 12441.39 nM (pChEMBL 4.909999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Ubiquitin-like FUBI-ribosomal protein eS30 fusion protein (SINGLE PROTEIN), Homo sapiens
UniProt: P62861
Assay: Binding affinity to human FAU incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 12441.39 nM (pChEMBL 4.909999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: rRNA 2'-O-methyltransferase fibrillarin (SINGLE PROTEIN), Homo sapiens
UniProt: P22087
Assay: Binding affinity to human FBL incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 21.38 nM (pChEMBL 7.670000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: rRNA 2'-O-methyltransferase fibrillarin (SINGLE PROTEIN), Homo sapiens
UniProt: P22087
Assay: Binding affinity to human FBL incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 21.38 nM (pChEMBL 7.670000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Squalene synthase (SINGLE PROTEIN), Homo sapiens
UniProt: P37268
Assay: Binding affinity to human FDFT1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2927.48 nM (pChEMBL 5.53000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Squalene synthase (SINGLE PROTEIN), Homo sapiens
UniProt: P37268
Assay: Binding affinity to human FDFT1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2927.48 nM (pChEMBL 5.53000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Farnesyl pyrophosphate synthase (SINGLE PROTEIN), Homo sapiens
UniProt: P14324
Assay: Binding affinity to human FDPS incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 54.31 nM (pChEMBL 7.260000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Farnesyl pyrophosphate synthase (SINGLE PROTEIN), Homo sapiens
UniProt: P14324
Assay: Binding affinity to human FDPS incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 54.31 nM (pChEMBL 7.260000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Ferrochelatase, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: P22830
Assay: Binding affinity to human FECH incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 8142.67 nM (pChEMBL 5.090000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Ferrochelatase, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: P22830
Assay: Binding affinity to human FECH incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 8184.12 nM (pChEMBL 5.090000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Flap endonuclease 1 (SINGLE PROTEIN), Homo sapiens
UniProt: P39748
Assay: Binding affinity to human FEN1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1024.65 nM (pChEMBL 5.989999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Flap endonuclease 1 (SINGLE PROTEIN), Homo sapiens
UniProt: P39748
Assay: Binding affinity to human FEN1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1024.65 nM (pChEMBL 5.989999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Tyrosine-protein kinase Fer (SINGLE PROTEIN), Homo sapiens
UniProt: P16591
Assay: Binding affinity to human FER incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 7.978 nM (pChEMBL 8.100000381469727)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Tyrosine-protein kinase Fer (SINGLE PROTEIN), Homo sapiens
UniProt: P16591
Assay: Binding affinity to human FER incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 18.89 nM (pChEMBL 7.71999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Tyrosine-protein kinase Fes/Fps (SINGLE PROTEIN), Homo sapiens
UniProt: P07332
Assay: Binding affinity to human FES incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 11.51 nM (pChEMBL 7.940000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Tyrosine-protein kinase Fes/Fps (SINGLE PROTEIN), Homo sapiens
UniProt: P07332
Assay: Binding affinity to human FES incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 31.14 nM (pChEMBL 7.510000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Fibroblast growth factor receptor 1 (SINGLE PROTEIN), Homo sapiens
UniProt: P11362
Assay: Binding affinity to human FGFR1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 38.71 nM (pChEMBL 7.409999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Fibroblast growth factor receptor 1 (SINGLE PROTEIN), Homo sapiens
UniProt: P11362
Assay: Binding affinity to human FGFR1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 52.58 nM (pChEMBL 7.28000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Fumarate hydratase, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: P07954
Assay: Binding affinity to human FH incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 36547.05 nM (pChEMBL 4.440000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Fumarate hydratase, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: P07954
Assay: Binding affinity to human FH incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 36547.05 nM (pChEMBL 4.440000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Acidic fibroblast growth factor intracellular-binding protein (SINGLE PROTEIN), Homo sapiens
UniProt: O43427
Assay: Binding affinity to human FIBP incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 17.15 nM (pChEMBL 7.769999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Acidic fibroblast growth factor intracellular-binding protein (SINGLE PROTEIN), Homo sapiens
UniProt: O43427
Assay: Binding affinity to human FIBP incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 30.07 nM (pChEMBL 7.519999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Mitochondrial fission 1 protein (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y3D6
Assay: Binding affinity to human FIS1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 7152.24 nM (pChEMBL 5.150000095367432)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32