lovingscience/chembl-v37-raw-activities huggingface dataset:
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Signal recognition particle subunit SRP54 (SINGLE PROTEIN), Homo sapiens
UniProt: P61011
Assay: Binding affinity to human SRP54 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 52336.9 nM (pChEMBL 4.28000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Signal recognition particle subunit SRP54 (SINGLE PROTEIN), Homo sapiens
UniProt: P61011
Assay: Binding affinity to human SRP54 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 52336.9 nM (pChEMBL 4.28000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Signal recognition particle subunit SRP68 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UHB9
Assay: Binding affinity to human SRP68 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 18.81 nM (pChEMBL 7.730000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Signal recognition particle subunit SRP68 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UHB9
Assay: Binding affinity to human SRP68 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 18.81 nM (pChEMBL 7.730000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Signal recognition particle subunit SRP72 (SINGLE PROTEIN), Homo sapiens
UniProt: O76094
Assay: Binding affinity to human SRP72 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 613.89 nM (pChEMBL 6.210000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Signal recognition particle subunit SRP72 (SINGLE PROTEIN), Homo sapiens
UniProt: O76094
Assay: Binding affinity to human SRP72 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 613.89 nM (pChEMBL 6.210000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Signal recognition particle 9 kDa protein (SINGLE PROTEIN), Homo sapiens
UniProt: P49458
Assay: Binding affinity to human SRP9 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2440579.09 nM (pChEMBL 2.609999895095825)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Signal recognition particle receptor subunit beta (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y5M8
Assay: Binding affinity to human SRPRB incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 43749.72 nM (pChEMBL 4.360000133514404)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Signal recognition particle receptor subunit beta (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y5M8
Assay: Binding affinity to human SRPRB incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 43749.72 nM (pChEMBL 4.360000133514404)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serrate RNA effector molecule homolog (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BXP5
Assay: Binding affinity to human SRRT incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1287.8 nM (pChEMBL 5.889999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serrate RNA effector molecule homolog (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BXP5
Assay: Binding affinity to human SRRT incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1287.8 nM (pChEMBL 5.889999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/arginine-rich splicing factor 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q07955
Assay: Binding affinity to human SRSF1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 56.22 nM (pChEMBL 7.25)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/arginine-rich splicing factor 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q07955
Assay: Binding affinity to human SRSF1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 56.22 nM (pChEMBL 7.25)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/arginine-rich splicing factor 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q01130
Assay: Binding affinity to human SRSF2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 9.308 nM (pChEMBL 8.029999732971191)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/arginine-rich splicing factor 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q01130
Assay: Binding affinity to human SRSF2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 9.308 nM (pChEMBL 8.029999732971191)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/arginine-rich splicing factor 3 (SINGLE PROTEIN), Homo sapiens
UniProt: P84103
Assay: Binding affinity to human SRSF3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 81.28 nM (pChEMBL 7.090000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/arginine-rich splicing factor 3 (SINGLE PROTEIN), Homo sapiens
UniProt: P84103
Assay: Binding affinity to human SRSF3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 81.28 nM (pChEMBL 7.090000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/arginine-rich splicing factor 6 (SINGLE PROTEIN), Homo sapiens
UniProt: Q13247
Assay: Binding affinity to human SRSF6 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 32488.85 nM (pChEMBL 4.489999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/arginine-rich splicing factor 6 (SINGLE PROTEIN), Homo sapiens
UniProt: Q13247
Assay: Binding affinity to human SRSF6 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 32488.85 nM (pChEMBL 4.489999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/arginine-rich splicing factor 7 (SINGLE PROTEIN), Homo sapiens
UniProt: Q16629
Assay: Binding affinity to human SRSF7 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 258.07 nM (pChEMBL 6.590000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/arginine-rich splicing factor 7 (SINGLE PROTEIN), Homo sapiens
UniProt: Q16629
Assay: Binding affinity to human SRSF7 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 258.07 nM (pChEMBL 6.590000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: SS18-like protein 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UHA2
Assay: Binding affinity to human SS18L2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 6.318 nM (pChEMBL 8.199999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: SS18-like protein 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UHA2
Assay: Binding affinity to human SS18L2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 6.318 nM (pChEMBL 8.199999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Lupus La protein (SINGLE PROTEIN), Homo sapiens
UniProt: P05455
Assay: Binding affinity to human SSB incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 27.85 nM (pChEMBL 7.550000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Lupus La protein (SINGLE PROTEIN), Homo sapiens
UniProt: P05455
Assay: Binding affinity to human SSB incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 27.85 nM (pChEMBL 7.550000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Single-stranded DNA-binding protein, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: Q04837
Assay: Binding affinity to human SSBP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 34.61 nM (pChEMBL 7.460000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Single-stranded DNA-binding protein, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: Q04837
Assay: Binding affinity to human SSBP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 34.61 nM (pChEMBL 7.460000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Translocon-associated protein subunit alpha (SINGLE PROTEIN), Homo sapiens
UniProt: P43307
Assay: Binding affinity to human SSR1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 16007.03 nM (pChEMBL 4.800000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Translocon-associated protein subunit alpha (SINGLE PROTEIN), Homo sapiens
UniProt: P43307
Assay: Binding affinity to human SSR1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 16007.03 nM (pChEMBL 4.800000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Translocon-associated protein subunit gamma (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UNL2
Assay: Binding affinity to human SSR3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 50.5 nM (pChEMBL 7.300000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Translocon-associated protein subunit gamma (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UNL2
Assay: Binding affinity to human SSR3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 50.5 nM (pChEMBL 7.300000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: FACT complex subunit SSRP1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q08945
Assay: Binding affinity to human SSRP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 3604.98 nM (pChEMBL 5.440000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: FACT complex subunit SSRP1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q08945
Assay: Binding affinity to human SSRP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 3604.98 nM (pChEMBL 5.440000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Signal transducer and activator of transcription 3 (SINGLE PROTEIN), Homo sapiens
UniProt: P40763
Assay: Binding affinity to human STAT3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 951.51 nM (pChEMBL 6.019999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Signal transducer and activator of transcription 3 (SINGLE PROTEIN), Homo sapiens
UniProt: P40763
Assay: Binding affinity to human STAT3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 951.51 nM (pChEMBL 6.019999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Double-stranded RNA-binding protein Staufen homolog 1 (SINGLE PROTEIN), Homo sapiens
UniProt: O95793
Assay: Binding affinity to human STAU1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 13.37 nM (pChEMBL 7.869999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Double-stranded RNA-binding protein Staufen homolog 1 (SINGLE PROTEIN), Homo sapiens
UniProt: O95793
Assay: Binding affinity to human STAU1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 13.37 nM (pChEMBL 7.869999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Stress-induced-phosphoprotein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: P31948
Assay: Binding affinity to human STIP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 57.67 nM (pChEMBL 7.239999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Stress-induced-phosphoprotein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: P31948
Assay: Binding affinity to human STIP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 57.67 nM (pChEMBL 7.239999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase 10 (SINGLE PROTEIN), Homo sapiens
UniProt: O94804
Assay: Binding affinity to human STK10 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 32.12 nM (pChEMBL 7.489999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase 10 (SINGLE PROTEIN), Homo sapiens
UniProt: O94804
Assay: Binding affinity to human STK10 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 35.08 nM (pChEMBL 7.460000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase STK11 (SINGLE PROTEIN), Homo sapiens
UniProt: Q15831
Assay: Binding affinity to human STK11 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 15.19 nM (pChEMBL 7.820000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase STK11 (SINGLE PROTEIN), Homo sapiens
UniProt: Q15831
Assay: Binding affinity to human STK11 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 18.01 nM (pChEMBL 7.739999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase 16 (SINGLE PROTEIN), Homo sapiens
UniProt: O75716
Assay: Binding affinity to human STK16 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 16.67 nM (pChEMBL 7.78000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase 16 (SINGLE PROTEIN), Homo sapiens
UniProt: O75716
Assay: Binding affinity to human STK16 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 23.15 nM (pChEMBL 7.630000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase 3 (SINGLE PROTEIN), Homo sapiens
UniProt: Q13188
Assay: Binding affinity to human STK3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 7125.65 nM (pChEMBL 5.150000095367432)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase 3 (SINGLE PROTEIN), Homo sapiens
UniProt: Q13188
Assay: Binding affinity to human STK3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 9323.78 nM (pChEMBL 5.03000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase 4 (SINGLE PROTEIN), Homo sapiens
UniProt: Q13043
Assay: Binding affinity to human STK4 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 37.96 nM (pChEMBL 7.420000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase 4 (SINGLE PROTEIN), Homo sapiens
UniProt: Q13043
Assay: Binding affinity to human STK4 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 49.78 nM (pChEMBL 7.300000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Stathmin (SINGLE PROTEIN), Homo sapiens
UniProt: P16949
Assay: Binding affinity to human STMN1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 8255.62 nM (pChEMBL 5.079999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Stathmin (SINGLE PROTEIN), Homo sapiens
UniProt: P16949
Assay: Binding affinity to human STMN1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 8255.62 nM (pChEMBL 5.079999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Stathmin-2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q93045
Assay: Binding affinity to human STMN2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 10480.75 nM (pChEMBL 4.980000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Stathmin-2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q93045
Assay: Binding affinity to human STMN2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 10480.75 nM (pChEMBL 4.980000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Stomatin (SINGLE PROTEIN), Homo sapiens
UniProt: P27105
Assay: Binding affinity to human STOM incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 19.05 nM (pChEMBL 7.71999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Stomatin (SINGLE PROTEIN), Homo sapiens
UniProt: P27105
Assay: Binding affinity to human STOM incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 19.05 nM (pChEMBL 7.71999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Stomatin-like protein 2, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UJZ1
Assay: Binding affinity to human STOML2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 38.58 nM (pChEMBL 7.409999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Stomatin-like protein 2, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UJZ1
Assay: Binding affinity to human STOML2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 38.58 nM (pChEMBL 7.409999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine-threonine kinase receptor-associated protein (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y3F4
Assay: Binding affinity to human STRAP incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 17.7 nM (pChEMBL 7.75)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine-threonine kinase receptor-associated protein (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y3F4
Assay: Binding affinity to human STRAP incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 17.7 nM (pChEMBL 7.75)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (SINGLE PROTEIN), Homo sapiens
UniProt: P46977
Assay: Binding affinity to human STT3A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 9.862 nM (pChEMBL 8.010000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3A (SINGLE PROTEIN), Homo sapiens
UniProt: P46977
Assay: Binding affinity to human STT3A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 9.862 nM (pChEMBL 8.010000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Syntaxin-18 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9P2W9
Assay: Binding affinity to human STX18 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 18.4 nM (pChEMBL 7.739999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Syntaxin-18 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9P2W9
Assay: Binding affinity to human STX18 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 18.4 nM (pChEMBL 7.739999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Syntaxin-binding protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: P61764
Assay: Binding affinity to human STXBP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1.474 nM (pChEMBL 8.829999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Syntaxin-binding protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: P61764
Assay: Binding affinity to human STXBP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1.474 nM (pChEMBL 8.829999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: Q9P2R7
Assay: Binding affinity to human SUCLA2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2392.84 nM (pChEMBL 5.619999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Succinate--CoA ligase [ADP-forming] subunit beta, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: Q9P2R7
Assay: Binding affinity to human SUCLA2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2392.84 nM (pChEMBL 5.619999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: P53597
Assay: Binding affinity to human SUCLG1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 877.32 nM (pChEMBL 6.059999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Succinate--CoA ligase [ADP/GDP-forming] subunit alpha, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: P53597
Assay: Binding affinity to human SUCLG1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 877.32 nM (pChEMBL 6.059999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: Q96I99
Assay: Binding affinity to human SUCLG2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 17.96 nM (pChEMBL 7.75)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Succinate--CoA ligase [GDP-forming] subunit beta, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: Q96I99
Assay: Binding affinity to human SUCLG2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 54.02 nM (pChEMBL 7.269999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein SGT1 homolog (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y2Z0
Assay: Binding affinity to human SUGT1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 4079.56 nM (pChEMBL 5.389999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein SGT1 homolog (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y2Z0
Assay: Binding affinity to human SUGT1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 4079.56 nM (pChEMBL 5.389999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ubiquitin-related modifier 2 (SINGLE PROTEIN), Homo sapiens
UniProt: P61956
Assay: Binding affinity to human SUMO2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 18286.75 nM (pChEMBL 4.739999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ubiquitin-related modifier 2 (SINGLE PROTEIN), Homo sapiens
UniProt: P61956
Assay: Binding affinity to human SUMO2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 18286.75 nM (pChEMBL 4.739999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: SUN domain-containing protein 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UH99
Assay: Binding affinity to human SUN2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 111.4 nM (pChEMBL 6.949999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: SUN domain-containing protein 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UH99
Assay: Binding affinity to human SUN2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 111.4 nM (pChEMBL 6.949999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: FACT complex subunit SPT16 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y5B9
Assay: Binding affinity to human SUPT16H incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 148.65 nM (pChEMBL 6.829999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: FACT complex subunit SPT16 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y5B9
Assay: Binding affinity to human SUPT16H incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 148.65 nM (pChEMBL 6.829999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Surfeit locus protein 4 (SINGLE PROTEIN), Homo sapiens
UniProt: O15260
Assay: Binding affinity to human SURF4 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 15.1 nM (pChEMBL 7.820000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Surfeit locus protein 4 (SINGLE PROTEIN), Homo sapiens
UniProt: O15260
Assay: Binding affinity to human SURF4 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 15.1 nM (pChEMBL 7.820000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Tyrosine-protein kinase SYK (SINGLE PROTEIN), Homo sapiens
UniProt: P43405
Assay: Binding affinity to human SYK incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 181.53 nM (pChEMBL 6.739999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Tyrosine-protein kinase SYK (SINGLE PROTEIN), Homo sapiens
UniProt: P43405
Assay: Binding affinity to human SYK incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 216.49 nM (pChEMBL 6.670000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Symplekin (SINGLE PROTEIN), Homo sapiens
UniProt: Q92797
Assay: Binding affinity to human SYMPK incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 3.418 nM (pChEMBL 8.470000267028809)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Symplekin (SINGLE PROTEIN), Homo sapiens
UniProt: Q92797
Assay: Binding affinity to human SYMPK incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 3.418 nM (pChEMBL 8.470000267028809)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Heterogeneous nuclear ribonucleoprotein Q (SINGLE PROTEIN), Homo sapiens
UniProt: O60506
Assay: Binding affinity to human SYNCRIP incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 295.76 nM (pChEMBL 6.53000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Heterogeneous nuclear ribonucleoprotein Q (SINGLE PROTEIN), Homo sapiens
UniProt: O60506
Assay: Binding affinity to human SYNCRIP incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 295.76 nM (pChEMBL 6.53000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Synaptogyrin-2 (SINGLE PROTEIN), Homo sapiens
UniProt: O43760
Assay: Binding affinity to human SYNGR2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1906.17 nM (pChEMBL 5.71999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Synaptogyrin-2 (SINGLE PROTEIN), Homo sapiens
UniProt: O43760
Assay: Binding affinity to human SYNGR2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1906.17 nM (pChEMBL 5.71999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Synaptophysin-like protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q16563
Assay: Binding affinity to human SYPL1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 51.77 nM (pChEMBL 7.289999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Synaptophysin-like protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q16563
Assay: Binding affinity to human SYPL1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 53.55 nM (pChEMBL 7.269999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: E3 ubiquitin-protein ligase synoviolin (SINGLE PROTEIN), Homo sapiens
UniProt: Q86TM6
Assay: Binding affinity to human SYVN1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 7.335 nM (pChEMBL 8.130000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: E3 ubiquitin-protein ligase synoviolin (SINGLE PROTEIN), Homo sapiens
UniProt: Q86TM6
Assay: Binding affinity to human SYVN1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 7.335 nM (pChEMBL 8.130000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: TATA-binding protein-associated factor 2N (SINGLE PROTEIN), Homo sapiens
UniProt: Q92804
Assay: Binding affinity to human TAF15 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 27.48 nM (pChEMBL 7.559999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: TATA-binding protein-associated factor 2N (SINGLE PROTEIN), Homo sapiens
UniProt: Q92804
Assay: Binding affinity to human TAF15 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 27.48 nM (pChEMBL 7.559999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Transgelin-2 (SINGLE PROTEIN), Homo sapiens
UniProt: P37802
Assay: Binding affinity to human TAGLN2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 102.2 nM (pChEMBL 6.989999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Transgelin-2 (SINGLE PROTEIN), Homo sapiens
UniProt: P37802
Assay: Binding affinity to human TAGLN2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 102.2 nM (pChEMBL 6.989999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Transaldolase (SINGLE PROTEIN), Homo sapiens
UniProt: P37837
Assay: Binding affinity to human TALDO1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 358.62 nM (pChEMBL 6.449999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Transaldolase (SINGLE PROTEIN), Homo sapiens
UniProt: P37837
Assay: Binding affinity to human TALDO1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 358.62 nM (pChEMBL 6.449999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: TRAF family member-associated NF-kappa-B activator (SINGLE PROTEIN), Homo sapiens
UniProt: Q92844
Assay: Binding affinity to human TANK incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 32.29 nM (pChEMBL 7.489999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: TRAF family member-associated NF-kappa-B activator (SINGLE PROTEIN), Homo sapiens
UniProt: Q92844
Assay: Binding affinity to human TANK incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 50.76 nM (pChEMBL 7.289999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase TAO1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q7L7X3
Assay: Binding affinity to human TAOK1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 11.86 nM (pChEMBL 7.929999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase TAO1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q7L7X3
Assay: Binding affinity to human TAOK1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 17.84 nM (pChEMBL 7.75)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase TAO2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UL54
Assay: Binding affinity to human TAOK2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2515.47 nM (pChEMBL 5.599999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase TAO2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UL54
Assay: Binding affinity to human TAOK2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 4266.3 nM (pChEMBL 5.369999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase TAO3 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9H2K8
Assay: Binding affinity to human TAOK3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 49.6 nM (pChEMBL 7.300000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase TAO3 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9H2K8
Assay: Binding affinity to human TAOK3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 64.12 nM (pChEMBL 7.190000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Antigen peptide transporter 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q03519
Assay: Binding affinity to human TAP2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 87.13 nM (pChEMBL 7.059999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Antigen peptide transporter 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q03519
Assay: Binding affinity to human TAP2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 87.13 nM (pChEMBL 7.059999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: tRNA (guanosine(18)-2'-O)-methyltransferase TARBP1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q13395
Assay: Binding affinity to human TARBP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 63109.38 nM (pChEMBL 4.199999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: tRNA (guanosine(18)-2'-O)-methyltransferase TARBP1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q13395
Assay: Binding affinity to human TARBP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 63109.38 nM (pChEMBL 4.199999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: TAR DNA-binding protein 43 (SINGLE PROTEIN), Homo sapiens
UniProt: Q13148
Assay: Binding affinity to human TARDBP incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 175.99 nM (pChEMBL 6.75)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: TAR DNA-binding protein 43 (SINGLE PROTEIN), Homo sapiens
UniProt: Q13148
Assay: Binding affinity to human TARDBP incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 175.99 nM (pChEMBL 6.75)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32