lovingscience/chembl-v37-raw-activities huggingface dataset:
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Replication protein A 70 kDa DNA-binding subunit (SINGLE PROTEIN), Homo sapiens
UniProt: P27694
Assay: Binding affinity to human RPA1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 10.36 nM (pChEMBL 7.989999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Replication protein A 70 kDa DNA-binding subunit (SINGLE PROTEIN), Homo sapiens
UniProt: P27694
Assay: Binding affinity to human RPA1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 10.36 nM (pChEMBL 7.989999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Replication protein A 14 kDa subunit (SINGLE PROTEIN), Homo sapiens
UniProt: P35244
Assay: Binding affinity to human RPA3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 10495.14 nM (pChEMBL 4.980000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Replication protein A 14 kDa subunit (SINGLE PROTEIN), Homo sapiens
UniProt: P35244
Assay: Binding affinity to human RPA3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 25330.61 nM (pChEMBL 4.599999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: RNA polymerase II-associated protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BWH6
Assay: Binding affinity to human RPAP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 6.447 nM (pChEMBL 8.1899995803833)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: RNA polymerase II-associated protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BWH6
Assay: Binding affinity to human RPAP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 6.447 nM (pChEMBL 8.1899995803833)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL16 (SINGLE PROTEIN), Homo sapiens
UniProt: P27635
Assay: Binding affinity to human RPL10 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 5785.36 nM (pChEMBL 5.239999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL16 (SINGLE PROTEIN), Homo sapiens
UniProt: P27635
Assay: Binding affinity to human RPL10 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 5785.36 nM (pChEMBL 5.239999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL1 (SINGLE PROTEIN), Homo sapiens
UniProt: P62906
Assay: Binding affinity to human RPL10A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 8921.84 nM (pChEMBL 5.050000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL1 (SINGLE PROTEIN), Homo sapiens
UniProt: P62906
Assay: Binding affinity to human RPL10A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 8921.84 nM (pChEMBL 5.050000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL5 (SINGLE PROTEIN), Homo sapiens
UniProt: P62913
Assay: Binding affinity to human RPL11 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1632.38 nM (pChEMBL 5.789999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL5 (SINGLE PROTEIN), Homo sapiens
UniProt: P62913
Assay: Binding affinity to human RPL11 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1632.38 nM (pChEMBL 5.789999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL11 (SINGLE PROTEIN), Homo sapiens
UniProt: P30050
Assay: Binding affinity to human RPL12 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 51.34 nM (pChEMBL 7.289999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL11 (SINGLE PROTEIN), Homo sapiens
UniProt: P30050
Assay: Binding affinity to human RPL12 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 51.34 nM (pChEMBL 7.289999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL13 (SINGLE PROTEIN), Homo sapiens
UniProt: P26373
Assay: Binding affinity to human RPL13 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 19.57 nM (pChEMBL 7.710000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL13 (SINGLE PROTEIN), Homo sapiens
UniProt: P26373
Assay: Binding affinity to human RPL13 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 19.57 nM (pChEMBL 7.710000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL13 (SINGLE PROTEIN), Homo sapiens
UniProt: P40429
Assay: Binding affinity to human RPL13A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 70.63 nM (pChEMBL 7.150000095367432)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL13 (SINGLE PROTEIN), Homo sapiens
UniProt: P40429
Assay: Binding affinity to human RPL13A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 70.63 nM (pChEMBL 7.150000095367432)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL14 (SINGLE PROTEIN), Homo sapiens
UniProt: P50914
Assay: Binding affinity to human RPL14 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 7314.96 nM (pChEMBL 5.139999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL14 (SINGLE PROTEIN), Homo sapiens
UniProt: P50914
Assay: Binding affinity to human RPL14 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 7314.96 nM (pChEMBL 5.139999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL15 (SINGLE PROTEIN), Homo sapiens
UniProt: P61313
Assay: Binding affinity to human RPL15 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 59.2 nM (pChEMBL 7.230000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL15 (SINGLE PROTEIN), Homo sapiens
UniProt: P61313
Assay: Binding affinity to human RPL15 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 59.2 nM (pChEMBL 7.230000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL22 (SINGLE PROTEIN), Homo sapiens
UniProt: P18621
Assay: Binding affinity to human RPL17 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 15791.45 nM (pChEMBL 4.800000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL22 (SINGLE PROTEIN), Homo sapiens
UniProt: P18621
Assay: Binding affinity to human RPL17 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 15791.45 nM (pChEMBL 4.800000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL18 (SINGLE PROTEIN), Homo sapiens
UniProt: Q07020
Assay: Binding affinity to human RPL18 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 107.36 nM (pChEMBL 6.96999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL18 (SINGLE PROTEIN), Homo sapiens
UniProt: Q07020
Assay: Binding affinity to human RPL18 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 107.36 nM (pChEMBL 6.96999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL20 (SINGLE PROTEIN), Homo sapiens
UniProt: Q02543
Assay: Binding affinity to human RPL18A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 3154.06 nM (pChEMBL 5.5)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL20 (SINGLE PROTEIN), Homo sapiens
UniProt: Q02543
Assay: Binding affinity to human RPL18A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 3154.06 nM (pChEMBL 5.5)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL21 (SINGLE PROTEIN), Homo sapiens
UniProt: P46778
Assay: Binding affinity to human RPL21 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 9953.23 nM (pChEMBL 5)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL21 (SINGLE PROTEIN), Homo sapiens
UniProt: P46778
Assay: Binding affinity to human RPL21 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 9953.23 nM (pChEMBL 5)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL22 (SINGLE PROTEIN), Homo sapiens
UniProt: P35268
Assay: Binding affinity to human RPL22 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 7.584 nM (pChEMBL 8.119999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL22 (SINGLE PROTEIN), Homo sapiens
UniProt: P35268
Assay: Binding affinity to human RPL22 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 7.584 nM (pChEMBL 8.119999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL14 (SINGLE PROTEIN), Homo sapiens
UniProt: P62829
Assay: Binding affinity to human RPL23 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 7500.63 nM (pChEMBL 5.119999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL14 (SINGLE PROTEIN), Homo sapiens
UniProt: P62829
Assay: Binding affinity to human RPL23 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 7500.63 nM (pChEMBL 5.119999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL23 (SINGLE PROTEIN), Homo sapiens
UniProt: P62750
Assay: Binding affinity to human RPL23A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 13.66 nM (pChEMBL 7.869999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL23 (SINGLE PROTEIN), Homo sapiens
UniProt: P62750
Assay: Binding affinity to human RPL23A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 13.66 nM (pChEMBL 7.869999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL24 (SINGLE PROTEIN), Homo sapiens
UniProt: P83731
Assay: Binding affinity to human RPL24 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 27012.96 nM (pChEMBL 4.570000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL24 (SINGLE PROTEIN), Homo sapiens
UniProt: P83731
Assay: Binding affinity to human RPL24 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 27012.96 nM (pChEMBL 4.570000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL24 (SINGLE PROTEIN), Homo sapiens
UniProt: P61254
Assay: Binding affinity to human RPL26 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 16.24 nM (pChEMBL 7.789999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL24 (SINGLE PROTEIN), Homo sapiens
UniProt: P61254
Assay: Binding affinity to human RPL26 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 16.24 nM (pChEMBL 7.789999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL27 (SINGLE PROTEIN), Homo sapiens
UniProt: P61353
Assay: Binding affinity to human RPL27 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 47.95 nM (pChEMBL 7.320000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL27 (SINGLE PROTEIN), Homo sapiens
UniProt: P61353
Assay: Binding affinity to human RPL27 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 47.95 nM (pChEMBL 7.320000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL15 (SINGLE PROTEIN), Homo sapiens
UniProt: P46776
Assay: Binding affinity to human RPL27A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 16703.64 nM (pChEMBL 4.78000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL15 (SINGLE PROTEIN), Homo sapiens
UniProt: P46776
Assay: Binding affinity to human RPL27A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 16703.64 nM (pChEMBL 4.78000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL28 (SINGLE PROTEIN), Homo sapiens
UniProt: P46779
Assay: Binding affinity to human RPL28 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 55.2 nM (pChEMBL 7.260000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL28 (SINGLE PROTEIN), Homo sapiens
UniProt: P46779
Assay: Binding affinity to human RPL28 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 55.2 nM (pChEMBL 7.260000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL3 (SINGLE PROTEIN), Homo sapiens
UniProt: P39023
Assay: Binding affinity to human RPL3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 10412.18 nM (pChEMBL 4.980000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL3 (SINGLE PROTEIN), Homo sapiens
UniProt: P39023
Assay: Binding affinity to human RPL3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 10412.18 nM (pChEMBL 4.980000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL30 (SINGLE PROTEIN), Homo sapiens
UniProt: P62888
Assay: Binding affinity to human RPL30 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1582.72 nM (pChEMBL 5.800000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL30 (SINGLE PROTEIN), Homo sapiens
UniProt: P62888
Assay: Binding affinity to human RPL30 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1582.72 nM (pChEMBL 5.800000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL31 (SINGLE PROTEIN), Homo sapiens
UniProt: P62899
Assay: Binding affinity to human RPL31 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 4.489 nM (pChEMBL 8.350000381469727)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL31 (SINGLE PROTEIN), Homo sapiens
UniProt: P62899
Assay: Binding affinity to human RPL31 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 4.489 nM (pChEMBL 8.350000381469727)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL34 (SINGLE PROTEIN), Homo sapiens
UniProt: P49207
Assay: Binding affinity to human RPL34 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 85.59 nM (pChEMBL 7.070000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL34 (SINGLE PROTEIN), Homo sapiens
UniProt: P49207
Assay: Binding affinity to human RPL34 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 85.59 nM (pChEMBL 7.070000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL29 (SINGLE PROTEIN), Homo sapiens
UniProt: P42766
Assay: Binding affinity to human RPL35 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 7.714 nM (pChEMBL 8.109999656677246)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL29 (SINGLE PROTEIN), Homo sapiens
UniProt: P42766
Assay: Binding affinity to human RPL35 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 7.714 nM (pChEMBL 8.109999656677246)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL33 (SINGLE PROTEIN), Homo sapiens
UniProt: P18077
Assay: Binding affinity to human RPL35A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 16.71 nM (pChEMBL 7.78000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL33 (SINGLE PROTEIN), Homo sapiens
UniProt: P18077
Assay: Binding affinity to human RPL35A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 16.71 nM (pChEMBL 7.78000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL36 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y3U8
Assay: Binding affinity to human RPL36 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 10.29 nM (pChEMBL 7.989999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL36 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y3U8
Assay: Binding affinity to human RPL36 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 10.29 nM (pChEMBL 7.989999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL43 (SINGLE PROTEIN), Homo sapiens
UniProt: P61513
Assay: Binding affinity to human RPL37A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 48.98 nM (pChEMBL 7.309999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL43 (SINGLE PROTEIN), Homo sapiens
UniProt: P61513
Assay: Binding affinity to human RPL37A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 48.98 nM (pChEMBL 7.309999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL38 (SINGLE PROTEIN), Homo sapiens
UniProt: P63173
Assay: Binding affinity to human RPL38 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 27.43 nM (pChEMBL 7.559999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL38 (SINGLE PROTEIN), Homo sapiens
UniProt: P63173
Assay: Binding affinity to human RPL38 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 27.43 nM (pChEMBL 7.559999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL4 (SINGLE PROTEIN), Homo sapiens
UniProt: P36578
Assay: Binding affinity to human RPL4 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 24906.3 nM (pChEMBL 4.599999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL4 (SINGLE PROTEIN), Homo sapiens
UniProt: P36578
Assay: Binding affinity to human RPL4 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 24906.3 nM (pChEMBL 4.599999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL18 (SINGLE PROTEIN), Homo sapiens
UniProt: P46777
Assay: Binding affinity to human RPL5 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 11539.35 nM (pChEMBL 4.940000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL18 (SINGLE PROTEIN), Homo sapiens
UniProt: P46777
Assay: Binding affinity to human RPL5 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 11539.35 nM (pChEMBL 4.940000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL6 (SINGLE PROTEIN), Homo sapiens
UniProt: Q02878
Assay: Binding affinity to human RPL6 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 66693.51 nM (pChEMBL 4.179999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL6 (SINGLE PROTEIN), Homo sapiens
UniProt: Q02878
Assay: Binding affinity to human RPL6 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 66693.51 nM (pChEMBL 4.179999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL30 (SINGLE PROTEIN), Homo sapiens
UniProt: P18124
Assay: Binding affinity to human RPL7 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 12290.41 nM (pChEMBL 4.909999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL30 (SINGLE PROTEIN), Homo sapiens
UniProt: P18124
Assay: Binding affinity to human RPL7 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 12290.41 nM (pChEMBL 4.909999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL8 (SINGLE PROTEIN), Homo sapiens
UniProt: P62424
Assay: Binding affinity to human RPL7A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 9778.57 nM (pChEMBL 5.010000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL8 (SINGLE PROTEIN), Homo sapiens
UniProt: P62424
Assay: Binding affinity to human RPL7A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 9778.57 nM (pChEMBL 5.010000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL2 (SINGLE PROTEIN), Homo sapiens
UniProt: P62917
Assay: Binding affinity to human RPL8 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 120.74 nM (pChEMBL 6.920000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL2 (SINGLE PROTEIN), Homo sapiens
UniProt: P62917
Assay: Binding affinity to human RPL8 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 120.74 nM (pChEMBL 6.920000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL6 (SINGLE PROTEIN), Homo sapiens
UniProt: P32969
Assay: Binding affinity to human RPL9 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 5230.62 nM (pChEMBL 5.28000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL6 (SINGLE PROTEIN), Homo sapiens
UniProt: P32969
Assay: Binding affinity to human RPL9 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 5230.62 nM (pChEMBL 5.28000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein P1 (SINGLE PROTEIN), Homo sapiens
UniProt: P05386
Assay: Binding affinity to human RPLP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 16595982.8 nM (pChEMBL 1.7799999713897705)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein P2 (SINGLE PROTEIN), Homo sapiens
UniProt: P05387
Assay: Binding affinity to human RPLP2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 48.25 nM (pChEMBL 7.320000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein P2 (SINGLE PROTEIN), Homo sapiens
UniProt: P05387
Assay: Binding affinity to human RPLP2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 48.25 nM (pChEMBL 7.320000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (SINGLE PROTEIN), Homo sapiens
UniProt: P04843
Assay: Binding affinity to human RPN1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 38.76 nM (pChEMBL 7.409999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1 (SINGLE PROTEIN), Homo sapiens
UniProt: P04843
Assay: Binding affinity to human RPN1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 38.76 nM (pChEMBL 7.409999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (SINGLE PROTEIN), Homo sapiens
UniProt: P04844
Assay: Binding affinity to human RPN2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 60.29 nM (pChEMBL 7.21999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2 (SINGLE PROTEIN), Homo sapiens
UniProt: P04844
Assay: Binding affinity to human RPN2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 60.29 nM (pChEMBL 7.21999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS10 (SINGLE PROTEIN), Homo sapiens
UniProt: P46783
Assay: Binding affinity to human RPS10 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 42.48 nM (pChEMBL 7.369999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS10 (SINGLE PROTEIN), Homo sapiens
UniProt: P46783
Assay: Binding affinity to human RPS10 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 42.48 nM (pChEMBL 7.369999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS17 (SINGLE PROTEIN), Homo sapiens
UniProt: P62280
Assay: Binding affinity to human RPS11 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 18.95 nM (pChEMBL 7.71999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS17 (SINGLE PROTEIN), Homo sapiens
UniProt: P62280
Assay: Binding affinity to human RPS11 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 18.95 nM (pChEMBL 7.71999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS12 (SINGLE PROTEIN), Homo sapiens
UniProt: P25398
Assay: Binding affinity to human RPS12 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 254.41 nM (pChEMBL 6.590000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS12 (SINGLE PROTEIN), Homo sapiens
UniProt: P25398
Assay: Binding affinity to human RPS12 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 254.41 nM (pChEMBL 6.590000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS15 (SINGLE PROTEIN), Homo sapiens
UniProt: P62277
Assay: Binding affinity to human RPS13 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 6.565 nM (pChEMBL 8.180000305175781)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS15 (SINGLE PROTEIN), Homo sapiens
UniProt: P62277
Assay: Binding affinity to human RPS13 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 6.565 nM (pChEMBL 8.180000305175781)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS19 (SINGLE PROTEIN), Homo sapiens
UniProt: P62841
Assay: Binding affinity to human RPS15 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 14.91 nM (pChEMBL 7.829999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS19 (SINGLE PROTEIN), Homo sapiens
UniProt: P62841
Assay: Binding affinity to human RPS15 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 14.91 nM (pChEMBL 7.829999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS8 (SINGLE PROTEIN), Homo sapiens
UniProt: P62244
Assay: Binding affinity to human RPS15A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 5319.23 nM (pChEMBL 5.269999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS8 (SINGLE PROTEIN), Homo sapiens
UniProt: P62244
Assay: Binding affinity to human RPS15A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 5319.23 nM (pChEMBL 5.269999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS9 (SINGLE PROTEIN), Homo sapiens
UniProt: P62249
Assay: Binding affinity to human RPS16 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 344.91 nM (pChEMBL 6.460000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS9 (SINGLE PROTEIN), Homo sapiens
UniProt: P62249
Assay: Binding affinity to human RPS16 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 344.91 nM (pChEMBL 6.460000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS17 (SINGLE PROTEIN), Homo sapiens
UniProt: P08708
Assay: Binding affinity to human RPS17 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1763.14 nM (pChEMBL 5.75)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS17 (SINGLE PROTEIN), Homo sapiens
UniProt: P08708
Assay: Binding affinity to human RPS17 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1763.14 nM (pChEMBL 5.75)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS13 (SINGLE PROTEIN), Homo sapiens
UniProt: P62269
Assay: Binding affinity to human RPS18 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 6.909 nM (pChEMBL 8.15999984741211)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS13 (SINGLE PROTEIN), Homo sapiens
UniProt: P62269
Assay: Binding affinity to human RPS18 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 6.909 nM (pChEMBL 8.15999984741211)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS19 (SINGLE PROTEIN), Homo sapiens
UniProt: P39019
Assay: Binding affinity to human RPS19 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 199.24 nM (pChEMBL 6.699999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS19 (SINGLE PROTEIN), Homo sapiens
UniProt: P39019
Assay: Binding affinity to human RPS19 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 199.24 nM (pChEMBL 6.699999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS5 (SINGLE PROTEIN), Homo sapiens
UniProt: P15880
Assay: Binding affinity to human RPS2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1825.35 nM (pChEMBL 5.739999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS5 (SINGLE PROTEIN), Homo sapiens
UniProt: P15880
Assay: Binding affinity to human RPS2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1825.35 nM (pChEMBL 5.739999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS10 (SINGLE PROTEIN), Homo sapiens
UniProt: P60866
Assay: Binding affinity to human RPS20 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 3626.94 nM (pChEMBL 5.440000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS10 (SINGLE PROTEIN), Homo sapiens
UniProt: P60866
Assay: Binding affinity to human RPS20 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 3626.94 nM (pChEMBL 5.440000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS21 (SINGLE PROTEIN), Homo sapiens
UniProt: P63220
Assay: Binding affinity to human RPS21 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 6.829 nM (pChEMBL 8.170000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS21 (SINGLE PROTEIN), Homo sapiens
UniProt: P63220
Assay: Binding affinity to human RPS21 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 6.829 nM (pChEMBL 8.170000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS12 (SINGLE PROTEIN), Homo sapiens
UniProt: P62266
Assay: Binding affinity to human RPS23 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 0.624 nM (pChEMBL 9.210000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32