lovingscience/chembl-v37-raw-activities huggingface dataset:
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: S-adenosylmethionine synthase isoform type-2 (SINGLE PROTEIN), Homo sapiens
UniProt: P31153
Assay: Binding affinity to human MAT2A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 11182.28 nM (pChEMBL 4.949999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: S-adenosylmethionine synthase isoform type-2 (SINGLE PROTEIN), Homo sapiens
UniProt: P31153
Assay: Binding affinity to human MAT2A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 11182.28 nM (pChEMBL 4.949999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Matrin-3 (SINGLE PROTEIN), Homo sapiens
UniProt: P43243
Assay: Binding affinity to human MATR3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 30972.89 nM (pChEMBL 4.510000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Matrin-3 (SINGLE PROTEIN), Homo sapiens
UniProt: P43243
Assay: Binding affinity to human MATR3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 30972.89 nM (pChEMBL 4.510000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Mitochondrial antiviral-signaling protein (SINGLE PROTEIN), Homo sapiens
UniProt: Q7Z434
Assay: Binding affinity to human MAVS incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 5243.38 nM (pChEMBL 5.28000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Mitochondrial antiviral-signaling protein (SINGLE PROTEIN), Homo sapiens
UniProt: Q7Z434
Assay: Binding affinity to human MAVS incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 5259.16 nM (pChEMBL 5.28000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7 (SINGLE PROTEIN), Homo sapiens
UniProt: Q96N66
Assay: Binding affinity to human MBOAT7 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 3400.51 nM (pChEMBL 5.46999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7 (SINGLE PROTEIN), Homo sapiens
UniProt: Q96N66
Assay: Binding affinity to human MBOAT7 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 3400.51 nM (pChEMBL 5.46999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: Q9HCC0
Assay: Binding affinity to human MCCC2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 24863.65 nM (pChEMBL 4.599999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Methylcrotonoyl-CoA carboxylase beta chain, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: Q9HCC0
Assay: Binding affinity to human MCCC2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 24863.65 nM (pChEMBL 4.599999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: DNA replication licensing factor MCM2 (SINGLE PROTEIN), Homo sapiens
UniProt: P49736
Assay: Binding affinity to human MCM2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 3386.08 nM (pChEMBL 5.46999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: DNA replication licensing factor MCM2 (SINGLE PROTEIN), Homo sapiens
UniProt: P49736
Assay: Binding affinity to human MCM2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 3386.08 nM (pChEMBL 5.46999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: DNA replication licensing factor MCM3 (SINGLE PROTEIN), Homo sapiens
UniProt: P25205
Assay: Binding affinity to human MCM3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 312.5 nM (pChEMBL 6.5)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: DNA replication licensing factor MCM3 (SINGLE PROTEIN), Homo sapiens
UniProt: P25205
Assay: Binding affinity to human MCM3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 312.5 nM (pChEMBL 6.5)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: DNA replication licensing factor MCM4 (SINGLE PROTEIN), Homo sapiens
UniProt: P33991
Assay: Binding affinity to human MCM4 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 73297.05 nM (pChEMBL 4.130000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: DNA replication licensing factor MCM4 (SINGLE PROTEIN), Homo sapiens
UniProt: P33991
Assay: Binding affinity to human MCM4 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 73297.05 nM (pChEMBL 4.130000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: DNA replication licensing factor MCM5 (SINGLE PROTEIN), Homo sapiens
UniProt: P33992
Assay: Binding affinity to human MCM5 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 6508.24 nM (pChEMBL 5.190000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: DNA replication licensing factor MCM5 (SINGLE PROTEIN), Homo sapiens
UniProt: P33992
Assay: Binding affinity to human MCM5 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 6508.24 nM (pChEMBL 5.190000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: DNA replication licensing factor MCM6 (SINGLE PROTEIN), Homo sapiens
UniProt: Q14566
Assay: Binding affinity to human MCM6 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 11057.06 nM (pChEMBL 4.960000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: DNA replication licensing factor MCM6 (SINGLE PROTEIN), Homo sapiens
UniProt: Q14566
Assay: Binding affinity to human MCM6 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 11057.06 nM (pChEMBL 4.960000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: DNA replication licensing factor MCM7 (SINGLE PROTEIN), Homo sapiens
UniProt: P33993
Assay: Binding affinity to human MCM7 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 5392.45 nM (pChEMBL 5.269999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: DNA replication licensing factor MCM7 (SINGLE PROTEIN), Homo sapiens
UniProt: P33993
Assay: Binding affinity to human MCM7 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 5392.45 nM (pChEMBL 5.269999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Malate dehydrogenase, cytoplasmic (SINGLE PROTEIN), Homo sapiens
UniProt: P40925
Assay: Binding affinity to human MDH1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 91416.37 nM (pChEMBL 4.039999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Malate dehydrogenase, cytoplasmic (SINGLE PROTEIN), Homo sapiens
UniProt: P40925
Assay: Binding affinity to human MDH1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 91416.37 nM (pChEMBL 4.039999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Malate dehydrogenase, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: P40926
Assay: Binding affinity to human MDH2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 19.78 nM (pChEMBL 7.699999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Malate dehydrogenase, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: P40926
Assay: Binding affinity to human MDH2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 19.78 nM (pChEMBL 7.699999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Midasin (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NU22
Assay: Binding affinity to human MDN1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 55543209.07 nM (pChEMBL 1.25)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Mediator of RNA polymerase II transcription subunit 23 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9ULK4
Assay: Binding affinity to human MED23 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 4854.09 nM (pChEMBL 5.309999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Mediator of RNA polymerase II transcription subunit 23 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9ULK4
Assay: Binding affinity to human MED23 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 4894.13 nM (pChEMBL 5.309999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Maternal embryonic leucine zipper kinase (SINGLE PROTEIN), Homo sapiens
UniProt: Q14680
Assay: Binding affinity to human MELK incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 15.52 nM (pChEMBL 7.809999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Maternal embryonic leucine zipper kinase (SINGLE PROTEIN), Homo sapiens
UniProt: Q14680
Assay: Binding affinity to human MELK incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 17.56 nM (pChEMBL 7.75)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Hepatocyte growth factor receptor (SINGLE PROTEIN), Homo sapiens
UniProt: P08581
Assay: Binding affinity to human MET incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1409.73 nM (pChEMBL 5.849999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Hepatocyte growth factor receptor (SINGLE PROTEIN), Homo sapiens
UniProt: P08581
Assay: Binding affinity to human MET incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1754.51 nM (pChEMBL 5.760000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Thiol S-methyltransferase TMT1A (SINGLE PROTEIN), Homo sapiens
UniProt: Q9H8H3
Assay: Binding affinity to human METTL7A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 25480 nM (pChEMBL 4.590000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Thiol S-methyltransferase TMT1A (SINGLE PROTEIN), Homo sapiens
UniProt: Q9H8H3
Assay: Binding affinity to human METTL7A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 30405.37 nM (pChEMBL 4.519999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Transport and Golgi organization protein 1 homolog (SINGLE PROTEIN), Homo sapiens
UniProt: Q5JRA6
Assay: Binding affinity to human MIA3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 3221.65 nM (pChEMBL 5.489999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Transport and Golgi organization protein 1 homolog (SINGLE PROTEIN), Homo sapiens
UniProt: Q5JRA6
Assay: Binding affinity to human MIA3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 3637.21 nM (pChEMBL 5.440000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Macrophage migration inhibitory factor (SINGLE PROTEIN), Homo sapiens
UniProt: P14174
Assay: Binding affinity to human MIF incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1.918 nM (pChEMBL 8.720000267028809)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Macrophage migration inhibitory factor (SINGLE PROTEIN), Homo sapiens
UniProt: P14174
Assay: Binding affinity to human MIF incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2.239 nM (pChEMBL 8.649999618530273)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Misshapen-like kinase 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q8N4C8
Assay: Binding affinity to human MINK1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 6349.42 nM (pChEMBL 5.199999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Misshapen-like kinase 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q8N4C8
Assay: Binding affinity to human MINK1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 6349.42 nM (pChEMBL 5.199999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Proliferation marker protein Ki-67 (SINGLE PROTEIN), Homo sapiens
UniProt: P46013
Assay: Binding affinity to human MKI67 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 4640.38 nM (pChEMBL 5.329999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Proliferation marker protein Ki-67 (SINGLE PROTEIN), Homo sapiens
UniProt: P46013
Assay: Binding affinity to human MKI67 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 4640.38 nM (pChEMBL 5.329999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Malectin (SINGLE PROTEIN), Homo sapiens
UniProt: Q14165
Assay: Binding affinity to human MLEC incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 95133.3 nM (pChEMBL 4.019999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Malectin (SINGLE PROTEIN), Homo sapiens
UniProt: Q14165
Assay: Binding affinity to human MLEC incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 95133.3 nM (pChEMBL 4.019999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: MMS19 nucleotide excision repair protein homolog (SINGLE PROTEIN), Homo sapiens
UniProt: Q96T76
Assay: Binding affinity to human MMS19 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 970.39 nM (pChEMBL 6.010000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: MMS19 nucleotide excision repair protein homolog (SINGLE PROTEIN), Homo sapiens
UniProt: Q96T76
Assay: Binding affinity to human MMS19 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 970.39 nM (pChEMBL 6.010000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: CDK-activating kinase assembly factor MAT1 (SINGLE PROTEIN), Homo sapiens
UniProt: P51948
Assay: Binding affinity to human MNAT1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 8.533 nM (pChEMBL 8.069999694824219)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: CDK-activating kinase assembly factor MAT1 (SINGLE PROTEIN), Homo sapiens
UniProt: P51948
Assay: Binding affinity to human MNAT1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 9.716 nM (pChEMBL 8.010000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Protein MON2 homolog (SINGLE PROTEIN), Homo sapiens
UniProt: Q7Z3U7
Assay: Binding affinity to human MON2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 3.821 nM (pChEMBL 8.420000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Protein MON2 homolog (SINGLE PROTEIN), Homo sapiens
UniProt: Q7Z3U7
Assay: Binding affinity to human MON2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 3.821 nM (pChEMBL 8.420000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Double-strand break repair protein MRE11 (SINGLE PROTEIN), Homo sapiens
UniProt: P49959
Assay: Binding affinity to human MRE11A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2590.29 nM (pChEMBL 5.590000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Double-strand break repair protein MRE11 (SINGLE PROTEIN), Homo sapiens
UniProt: P49959
Assay: Binding affinity to human MRE11A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2590.29 nM (pChEMBL 5.590000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein bL12m (SINGLE PROTEIN), Homo sapiens
UniProt: P52815
Assay: Binding affinity to human MRPL12 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 7738.28 nM (pChEMBL 5.110000133514404)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein bL12m (SINGLE PROTEIN), Homo sapiens
UniProt: P52815
Assay: Binding affinity to human MRPL12 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 7738.28 nM (pChEMBL 5.110000133514404)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS17m (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y2R5
Assay: Binding affinity to human MRPS17 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 393.33 nM (pChEMBL 6.409999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS17m (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y2R5
Assay: Binding affinity to human MRPS17 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 420.68 nM (pChEMBL 6.380000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein mS23 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y3D9
Assay: Binding affinity to human MRPS23 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 20164.9 nM (pChEMBL 4.699999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein mS23 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y3D9
Assay: Binding affinity to human MRPS23 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 20164.9 nM (pChEMBL 4.699999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein mS27 (SINGLE PROTEIN), Homo sapiens
UniProt: Q92552
Assay: Binding affinity to human MRPS27 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 99.01 nM (pChEMBL 7)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein mS27 (SINGLE PROTEIN), Homo sapiens
UniProt: Q92552
Assay: Binding affinity to human MRPS27 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 99.01 nM (pChEMBL 7)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS7m (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y2R9
Assay: Binding affinity to human MRPS7 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 7183.97 nM (pChEMBL 5.139999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS7m (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y2R9
Assay: Binding affinity to human MRPS7 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 7183.97 nM (pChEMBL 5.139999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: mRNA turnover protein 4 homolog (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UKD2
Assay: Binding affinity to human MRTO4 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 10772.28 nM (pChEMBL 4.96999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: mRNA turnover protein 4 homolog (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UKD2
Assay: Binding affinity to human MRTO4 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 10772.28 nM (pChEMBL 4.96999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: DNA mismatch repair protein Msh6 (SINGLE PROTEIN), Homo sapiens
UniProt: P52701
Assay: Binding affinity to human MSH6 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 37480.62 nM (pChEMBL 4.429999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: DNA mismatch repair protein Msh6 (SINGLE PROTEIN), Homo sapiens
UniProt: P52701
Assay: Binding affinity to human MSH6 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 37480.62 nM (pChEMBL 4.429999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Moesin (SINGLE PROTEIN), Homo sapiens
UniProt: P26038
Assay: Binding affinity to human MSN incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 10674.05 nM (pChEMBL 4.96999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Moesin (SINGLE PROTEIN), Homo sapiens
UniProt: P26038
Assay: Binding affinity to human MSN incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 10674.05 nM (pChEMBL 4.96999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Macrophage-stimulating protein receptor (SINGLE PROTEIN), Homo sapiens
UniProt: Q04912
Assay: Binding affinity to human MST1R incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 69.38 nM (pChEMBL 7.159999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Macrophage-stimulating protein receptor (SINGLE PROTEIN), Homo sapiens
UniProt: Q04912
Assay: Binding affinity to human MST1R incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 91.06 nM (pChEMBL 7.039999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: ATP synthase F(0) complex subunit a (SINGLE PROTEIN), Homo sapiens
UniProt: P00846
Assay: Binding affinity to human MT-ATP6 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 676.89 nM (pChEMBL 6.170000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: ATP synthase F(0) complex subunit a (SINGLE PROTEIN), Homo sapiens
UniProt: P00846
Assay: Binding affinity to human MT-ATP6 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 676.89 nM (pChEMBL 6.170000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Mitochondrial carrier homolog 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y6C9
Assay: Binding affinity to human MTCH2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 27.95 nM (pChEMBL 7.550000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Mitochondrial carrier homolog 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y6C9
Assay: Binding affinity to human MTCH2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 27.95 nM (pChEMBL 7.550000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Cytochrome c oxidase subunit 2 (SINGLE PROTEIN), Homo sapiens
UniProt: P00403
Assay: Binding affinity to human MT-CO2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 449.08 nM (pChEMBL 6.349999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Cytochrome c oxidase subunit 2 (SINGLE PROTEIN), Homo sapiens
UniProt: P00403
Assay: Binding affinity to human MT-CO2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 449.08 nM (pChEMBL 6.349999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Protein LYRIC (SINGLE PROTEIN), Homo sapiens
UniProt: Q86UE4
Assay: Binding affinity to human MTDH incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 4505.84 nM (pChEMBL 5.349999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Protein LYRIC (SINGLE PROTEIN), Homo sapiens
UniProt: Q86UE4
Assay: Binding affinity to human MTDH incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 4505.84 nM (pChEMBL 5.349999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: C-1-tetrahydrofolate synthase, cytoplasmic (SINGLE PROTEIN), Homo sapiens
UniProt: P11586
Assay: Binding affinity to human MTHFD1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 30341.2 nM (pChEMBL 4.519999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: C-1-tetrahydrofolate synthase, cytoplasmic (SINGLE PROTEIN), Homo sapiens
UniProt: P11586
Assay: Binding affinity to human MTHFD1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 30341.2 nM (pChEMBL 4.519999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase mTOR (SINGLE PROTEIN), Homo sapiens
UniProt: P42345
Assay: Binding affinity to human MTOR incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 11579.09 nM (pChEMBL 4.940000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase mTOR (SINGLE PROTEIN), Homo sapiens
UniProt: P42345
Assay: Binding affinity to human MTOR incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 11579.09 nM (pChEMBL 4.940000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Metaxin-2 (SINGLE PROTEIN), Homo sapiens
UniProt: O75431
Assay: Binding affinity to human MTX2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 10.11 nM (pChEMBL 8)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Metaxin-2 (SINGLE PROTEIN), Homo sapiens
UniProt: O75431
Assay: Binding affinity to human MTX2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 10.11 nM (pChEMBL 8)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Myosin-9 (SINGLE PROTEIN), Homo sapiens
UniProt: P35579
Assay: Binding affinity to human MYH9 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 756.12 nM (pChEMBL 6.119999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Myosin-9 (SINGLE PROTEIN), Homo sapiens
UniProt: P35579
Assay: Binding affinity to human MYH9 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 756.12 nM (pChEMBL 6.119999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Myosin light polypeptide 6 (SINGLE PROTEIN), Homo sapiens
UniProt: P60660
Assay: Binding affinity to human MYL6 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 5789.62 nM (pChEMBL 5.239999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Myosin light polypeptide 6 (SINGLE PROTEIN), Homo sapiens
UniProt: P60660
Assay: Binding affinity to human MYL6 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 5789.62 nM (pChEMBL 5.239999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Myosin light chain kinase, smooth muscle (SINGLE PROTEIN), Homo sapiens
UniProt: Q15746
Assay: Binding affinity to human MYLK incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 205.66 nM (pChEMBL 6.690000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Myosin light chain kinase, smooth muscle (SINGLE PROTEIN), Homo sapiens
UniProt: Q15746
Assay: Binding affinity to human MYLK incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 246.82 nM (pChEMBL 6.610000133514404)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Unconventional myosin-If (SINGLE PROTEIN), Homo sapiens
UniProt: O00160
Assay: Binding affinity to human MYO1F incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 4428.56 nM (pChEMBL 5.349999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Unconventional myosin-If (SINGLE PROTEIN), Homo sapiens
UniProt: O00160
Assay: Binding affinity to human MYO1F incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 4428.56 nM (pChEMBL 5.349999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: N-alpha-acetyltransferase 15, NatA auxiliary subunit (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BXJ9
Assay: Binding affinity to human NAA15 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 11717.31 nM (pChEMBL 4.929999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: N-alpha-acetyltransferase 15, NatA auxiliary subunit (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BXJ9
Assay: Binding affinity to human NAA15 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 11717.31 nM (pChEMBL 4.929999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Nascent polypeptide-associated complex subunit alpha (SINGLE PROTEIN), Homo sapiens
UniProt: Q13765
Assay: Binding affinity to human NACA incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 90.11 nM (pChEMBL 7.039999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Nascent polypeptide-associated complex subunit alpha (SINGLE PROTEIN), Homo sapiens
UniProt: Q13765
Assay: Binding affinity to human NACA incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 90.11 nM (pChEMBL 7.039999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: N-acetylneuraminate-9-phosphate synthase (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NR45
Assay: Binding affinity to human NANS incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 38872.13 nM (pChEMBL 4.409999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: N-acetylneuraminate-9-phosphate synthase (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NR45
Assay: Binding affinity to human NANS incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 38872.13 nM (pChEMBL 4.409999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Nucleosome assembly protein 1-like 1 (SINGLE PROTEIN), Homo sapiens
UniProt: P55209
Assay: Binding affinity to human NAP1L1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 3102.19 nM (pChEMBL 5.510000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Nucleosome assembly protein 1-like 1 (SINGLE PROTEIN), Homo sapiens
UniProt: P55209
Assay: Binding affinity to human NAP1L1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 3102.19 nM (pChEMBL 5.510000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Nucleosome assembly protein 1-like 4 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99733
Assay: Binding affinity to human NAP1L4 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 9201.56 nM (pChEMBL 5.039999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Nucleosome assembly protein 1-like 4 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99733
Assay: Binding affinity to human NAP1L4 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 9201.56 nM (pChEMBL 5.039999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Asparagine--tRNA ligase, cytoplasmic (SINGLE PROTEIN), Homo sapiens
UniProt: O43776
Assay: Binding affinity to human NARS incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 28.36 nM (pChEMBL 7.550000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Asparagine--tRNA ligase, cytoplasmic (SINGLE PROTEIN), Homo sapiens
UniProt: O43776
Assay: Binding affinity to human NARS incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 28.36 nM (pChEMBL 7.550000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: RNA cytidine acetyltransferase (SINGLE PROTEIN), Homo sapiens
UniProt: Q9H0A0
Assay: Binding affinity to human NAT10 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 0.302 nM (pChEMBL 9.520000457763672)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: RNA cytidine acetyltransferase (SINGLE PROTEIN), Homo sapiens
UniProt: Q9H0A0
Assay: Binding affinity to human NAT10 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 0.302 nM (pChEMBL 9.520000457763672)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: NBAS subunit of NRZ tethering complex (SINGLE PROTEIN), Homo sapiens
UniProt: A2RRP1
Assay: Binding affinity to human NBAS incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 40.65 nM (pChEMBL 7.389999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: NBAS subunit of NRZ tethering complex (SINGLE PROTEIN), Homo sapiens
UniProt: A2RRP1
Assay: Binding affinity to human NBAS incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 41.67 nM (pChEMBL 7.380000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Nuclear cap-binding protein subunit 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q09161
Assay: Binding affinity to human NCBP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 0.799 nM (pChEMBL 9.100000381469727)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Nuclear cap-binding protein subunit 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q09161
Assay: Binding affinity to human NCBP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 0.799 nM (pChEMBL 9.100000381469727)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Nck-associated protein 1-like (SINGLE PROTEIN), Homo sapiens
UniProt: P55160
Assay: Binding affinity to human NCKAP1L incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 41488.08 nM (pChEMBL 4.380000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Nck-associated protein 1-like (SINGLE PROTEIN), Homo sapiens
UniProt: P55160
Assay: Binding affinity to human NCKAP1L incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 41488.08 nM (pChEMBL 4.380000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32