lovingscience/chembl-v37-raw-activities huggingface dataset:
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS12 (SINGLE PROTEIN), Homo sapiens
UniProt: P62266
Assay: Binding affinity to human RPS23 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 0.624 nM (pChEMBL 9.210000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS24 (SINGLE PROTEIN), Homo sapiens
UniProt: P62847
Assay: Binding affinity to human RPS24 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 313.87 nM (pChEMBL 6.5)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS24 (SINGLE PROTEIN), Homo sapiens
UniProt: P62847
Assay: Binding affinity to human RPS24 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 313.87 nM (pChEMBL 6.5)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS25 (SINGLE PROTEIN), Homo sapiens
UniProt: P62851
Assay: Binding affinity to human RPS25 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 200.12 nM (pChEMBL 6.699999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS25 (SINGLE PROTEIN), Homo sapiens
UniProt: P62851
Assay: Binding affinity to human RPS25 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 200.12 nM (pChEMBL 6.699999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS27 (SINGLE PROTEIN), Homo sapiens
UniProt: P42677
Assay: Binding affinity to human RPS27 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 469.72 nM (pChEMBL 6.329999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS27 (SINGLE PROTEIN), Homo sapiens
UniProt: P42677
Assay: Binding affinity to human RPS27 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 469.72 nM (pChEMBL 6.329999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Ribosomal protein eS27-like (SINGLE PROTEIN), Homo sapiens
UniProt: Q71UM5
Assay: Binding affinity to human RPS27L incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 4.316 nM (pChEMBL 8.369999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Ribosomal protein eS27-like (SINGLE PROTEIN), Homo sapiens
UniProt: Q71UM5
Assay: Binding affinity to human RPS27L incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 4.316 nM (pChEMBL 8.369999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS28 (SINGLE PROTEIN), Homo sapiens
UniProt: P62857
Assay: Binding affinity to human RPS28 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 59.5 nM (pChEMBL 7.21999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS28 (SINGLE PROTEIN), Homo sapiens
UniProt: P62857
Assay: Binding affinity to human RPS28 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 59.5 nM (pChEMBL 7.21999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS14 (SINGLE PROTEIN), Homo sapiens
UniProt: P62273
Assay: Binding affinity to human RPS29 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 9.327 nM (pChEMBL 8.029999732971191)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS14 (SINGLE PROTEIN), Homo sapiens
UniProt: P62273
Assay: Binding affinity to human RPS29 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 9.327 nM (pChEMBL 8.029999732971191)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS3 (SINGLE PROTEIN), Homo sapiens
UniProt: P23396
Assay: Binding affinity to human RPS3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 40.59 nM (pChEMBL 7.389999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS3 (SINGLE PROTEIN), Homo sapiens
UniProt: P23396
Assay: Binding affinity to human RPS3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 40.59 nM (pChEMBL 7.389999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS4, X isoform (SINGLE PROTEIN), Homo sapiens
UniProt: P62701
Assay: Binding affinity to human RPS4X incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 514.78 nM (pChEMBL 6.289999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS4, X isoform (SINGLE PROTEIN), Homo sapiens
UniProt: P62701
Assay: Binding affinity to human RPS4X incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 514.78 nM (pChEMBL 6.289999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS7 (SINGLE PROTEIN), Homo sapiens
UniProt: P46782
Assay: Binding affinity to human RPS5 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 50.07 nM (pChEMBL 7.300000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS7 (SINGLE PROTEIN), Homo sapiens
UniProt: P46782
Assay: Binding affinity to human RPS5 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 50.07 nM (pChEMBL 7.300000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS6 (SINGLE PROTEIN), Homo sapiens
UniProt: P62753
Assay: Binding affinity to human RPS6 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 61.01 nM (pChEMBL 7.210000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS6 (SINGLE PROTEIN), Homo sapiens
UniProt: P62753
Assay: Binding affinity to human RPS6 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 61.01 nM (pChEMBL 7.210000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Ribosomal protein S6 kinase alpha-1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q15418
Assay: Binding affinity to human RPS6KA1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1344.48 nM (pChEMBL 5.869999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Ribosomal protein S6 kinase alpha-1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q15418
Assay: Binding affinity to human RPS6KA1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1787.9 nM (pChEMBL 5.75)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Ribosomal protein S6 kinase alpha-3 (SINGLE PROTEIN), Homo sapiens
UniProt: P51812
Assay: Binding affinity to human RPS6KA3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 5737.54 nM (pChEMBL 5.239999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Ribosomal protein S6 kinase alpha-3 (SINGLE PROTEIN), Homo sapiens
UniProt: P51812
Assay: Binding affinity to human RPS6KA3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 7915.55 nM (pChEMBL 5.099999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Ribosomal protein S6 kinase alpha-4 (SINGLE PROTEIN), Homo sapiens
UniProt: O75676
Assay: Binding affinity to human RPS6KA4 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 95.15 nM (pChEMBL 7.019999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Ribosomal protein S6 kinase alpha-4 (SINGLE PROTEIN), Homo sapiens
UniProt: O75676
Assay: Binding affinity to human RPS6KA4 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 154.12 nM (pChEMBL 6.809999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Ribosomal protein S6 kinase alpha-5 (SINGLE PROTEIN), Homo sapiens
UniProt: O75582
Assay: Binding affinity to human RPS6KA5 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1869.31 nM (pChEMBL 5.730000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Ribosomal protein S6 kinase alpha-5 (SINGLE PROTEIN), Homo sapiens
UniProt: O75582
Assay: Binding affinity to human RPS6KA5 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2763.69 nM (pChEMBL 5.559999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Ribosomal protein S6 kinase alpha-6 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UK32
Assay: Binding affinity to human RPS6KA6 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 20413671 nM (pChEMBL 1.690000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS7 (SINGLE PROTEIN), Homo sapiens
UniProt: P62081
Assay: Binding affinity to human RPS7 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 6989.04 nM (pChEMBL 5.159999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS7 (SINGLE PROTEIN), Homo sapiens
UniProt: P62081
Assay: Binding affinity to human RPS7 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 6989.04 nM (pChEMBL 5.159999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS8 (SINGLE PROTEIN), Homo sapiens
UniProt: P62241
Assay: Binding affinity to human RPS8 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 9509.82 nM (pChEMBL 5.019999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein eS8 (SINGLE PROTEIN), Homo sapiens
UniProt: P62241
Assay: Binding affinity to human RPS8 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 9509.82 nM (pChEMBL 5.019999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS4 (SINGLE PROTEIN), Homo sapiens
UniProt: P46781
Assay: Binding affinity to human RPS9 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 0.236 nM (pChEMBL 9.630000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS4 (SINGLE PROTEIN), Homo sapiens
UniProt: P46781
Assay: Binding affinity to human RPS9 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 0.236 nM (pChEMBL 9.630000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: CCR4-NOT transcription complex subunit 9 (SINGLE PROTEIN), Homo sapiens
UniProt: Q92600
Assay: Binding affinity to human RQCD1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 28.7 nM (pChEMBL 7.539999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: CCR4-NOT transcription complex subunit 9 (SINGLE PROTEIN), Homo sapiens
UniProt: Q92600
Assay: Binding affinity to human RQCD1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 29.8 nM (pChEMBL 7.53000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Ribosome-binding protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9P2E9
Assay: Binding affinity to human RRBP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 277.27 nM (pChEMBL 6.559999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Ribosome-binding protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9P2E9
Assay: Binding affinity to human RRBP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 277.27 nM (pChEMBL 6.559999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Ribonucleoside-diphosphate reductase large subunit (SINGLE PROTEIN), Homo sapiens
UniProt: P23921
Assay: Binding affinity to human RRM1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 5741.46 nM (pChEMBL 5.239999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Ribonucleoside-diphosphate reductase large subunit (SINGLE PROTEIN), Homo sapiens
UniProt: P23921
Assay: Binding affinity to human RRM1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 5741.46 nM (pChEMBL 5.239999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: RRP12-like protein (SINGLE PROTEIN), Homo sapiens
UniProt: Q5JTH9
Assay: Binding affinity to human RRP12 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 0.256 nM (pChEMBL 9.59000015258789)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: RRP12-like protein (SINGLE PROTEIN), Homo sapiens
UniProt: Q5JTH9
Assay: Binding affinity to human RRP12 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 0.256 nM (pChEMBL 9.59000015258789)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: RRP15-like protein (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y3B9
Assay: Binding affinity to human RRP15 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1176.81 nM (pChEMBL 5.929999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: RRP15-like protein (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y3B9
Assay: Binding affinity to human RRP15 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1176.81 nM (pChEMBL 5.929999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Ribosomal RNA processing protein 1 homolog B (SINGLE PROTEIN), Homo sapiens
UniProt: Q14684
Assay: Binding affinity to human RRP1B incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1734.4 nM (pChEMBL 5.760000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Ribosomal RNA processing protein 1 homolog B (SINGLE PROTEIN), Homo sapiens
UniProt: Q14684
Assay: Binding affinity to human RRP1B incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1734.4 nM (pChEMBL 5.760000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Ribosome biogenesis regulatory protein homolog (SINGLE PROTEIN), Homo sapiens
UniProt: Q15050
Assay: Binding affinity to human RRS1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 53.89 nM (pChEMBL 7.269999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Ribosome biogenesis regulatory protein homolog (SINGLE PROTEIN), Homo sapiens
UniProt: Q15050
Assay: Binding affinity to human RRS1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 53.89 nM (pChEMBL 7.269999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: RNA-splicing ligase RtcB homolog (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y3I0
Assay: Binding affinity to human RTCB incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 38.31 nM (pChEMBL 7.420000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: RNA-splicing ligase RtcB homolog (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y3I0
Assay: Binding affinity to human RTCB incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 38.31 nM (pChEMBL 7.420000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Reticulon-3 (SINGLE PROTEIN), Homo sapiens
UniProt: O95197
Assay: Binding affinity to human RTN3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 20.58 nM (pChEMBL 7.690000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Reticulon-3 (SINGLE PROTEIN), Homo sapiens
UniProt: O95197
Assay: Binding affinity to human RTN3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 20.58 nM (pChEMBL 7.690000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Reticulon-4 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NQC3
Assay: Binding affinity to human RTN4 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 3549.52 nM (pChEMBL 5.449999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Reticulon-4 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NQC3
Assay: Binding affinity to human RTN4 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 3549.52 nM (pChEMBL 5.449999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: RuvB-like 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y265
Assay: Binding affinity to human RUVBL1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 8412.45 nM (pChEMBL 5.079999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: RuvB-like 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y265
Assay: Binding affinity to human RUVBL1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 8412.45 nM (pChEMBL 5.079999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: RuvB-like 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y230
Assay: Binding affinity to human RUVBL2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 47.77 nM (pChEMBL 7.320000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: RuvB-like 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y230
Assay: Binding affinity to human RUVBL2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 47.77 nM (pChEMBL 7.320000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein S100-A10 (SINGLE PROTEIN), Homo sapiens
UniProt: P60903
Assay: Binding affinity to human S100A10 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 382.26 nM (pChEMBL 6.420000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein S100-A10 (SINGLE PROTEIN), Homo sapiens
UniProt: P60903
Assay: Binding affinity to human S100A10 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 382.26 nM (pChEMBL 6.420000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein S100-A11 (SINGLE PROTEIN), Homo sapiens
UniProt: P31949
Assay: Binding affinity to human S100A11 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 30936.13 nM (pChEMBL 4.510000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein S100-A11 (SINGLE PROTEIN), Homo sapiens
UniProt: P31949
Assay: Binding affinity to human S100A11 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 30936.13 nM (pChEMBL 4.510000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein S100-A6 (SINGLE PROTEIN), Homo sapiens
UniProt: P06703
Assay: Binding affinity to human S100A6 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 11528.77 nM (pChEMBL 4.940000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein S100-A6 (SINGLE PROTEIN), Homo sapiens
UniProt: P06703
Assay: Binding affinity to human S100A6 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 11528.77 nM (pChEMBL 4.940000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein S100-P (SINGLE PROTEIN), Homo sapiens
UniProt: P25815
Assay: Binding affinity to human S100P incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 583.43 nM (pChEMBL 6.230000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein S100-P (SINGLE PROTEIN), Homo sapiens
UniProt: P25815
Assay: Binding affinity to human S100P incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 583.43 nM (pChEMBL 6.230000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein SAAL1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q96ER3
Assay: Binding affinity to human SAAL1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 827626.41 nM (pChEMBL 3.0799999237060547)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Phosphatidylinositol-3-phosphatase SAC1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NTJ5
Assay: Binding affinity to human SACM1L incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 44.1 nM (pChEMBL 7.360000133514404)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Phosphatidylinositol-3-phosphatase SAC1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NTJ5
Assay: Binding affinity to human SACM1L incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 44.1 nM (pChEMBL 7.360000133514404)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: SUMO-activating enzyme subunit 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UBE0
Assay: Binding affinity to human SAE1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 56788.69 nM (pChEMBL 4.25)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: SUMO-activating enzyme subunit 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UBE0
Assay: Binding affinity to human SAE1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 56788.69 nM (pChEMBL 4.25)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y3Z3
Assay: Binding affinity to human SAMHD1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 12779.84 nM (pChEMBL 4.889999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Deoxynucleoside triphosphate triphosphohydrolase SAMHD1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y3Z3
Assay: Binding affinity to human SAMHD1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 12779.84 nM (pChEMBL 4.889999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Sorting and assembly machinery component 50 homolog (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y512
Assay: Binding affinity to human SAMM50 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 8.063 nM (pChEMBL 8.09000015258789)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Sorting and assembly machinery component 50 homolog (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y512
Assay: Binding affinity to human SAMM50 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 8.063 nM (pChEMBL 8.09000015258789)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: SAM domain-containing protein SAMSN-1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NSI8
Assay: Binding affinity to human SAMSN1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 6.486 nM (pChEMBL 8.1899995803833)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: SAM domain-containing protein SAMSN-1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NSI8
Assay: Binding affinity to human SAMSN1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 6.486 nM (pChEMBL 8.1899995803833)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Store-operated calcium entry-associated regulatory factor (SINGLE PROTEIN), Homo sapiens
UniProt: Q96BY9
Assay: Binding affinity to human SARAF incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 147.22 nM (pChEMBL 6.829999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Store-operated calcium entry-associated regulatory factor (SINGLE PROTEIN), Homo sapiens
UniProt: Q96BY9
Assay: Binding affinity to human SARAF incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 153.53 nM (pChEMBL 6.809999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: SAP domain-containing ribonucleoprotein (SINGLE PROTEIN), Homo sapiens
UniProt: P82979
Assay: Binding affinity to human SARNP incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 13427.29 nM (pChEMBL 4.869999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: SAP domain-containing ribonucleoprotein (SINGLE PROTEIN), Homo sapiens
UniProt: P82979
Assay: Binding affinity to human SARNP incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 13427.29 nM (pChEMBL 4.869999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine--tRNA ligase, cytoplasmic (SINGLE PROTEIN), Homo sapiens
UniProt: P49591
Assay: Binding affinity to human SARS incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 90191.4 nM (pChEMBL 4.039999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine--tRNA ligase, cytoplasmic (SINGLE PROTEIN), Homo sapiens
UniProt: P49591
Assay: Binding affinity to human SARS incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 90191.4 nM (pChEMBL 4.039999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Spliceosome associated factor 3, U4/U6 recycling protein (SINGLE PROTEIN), Homo sapiens
UniProt: Q15020
Assay: Binding affinity to human SART3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 68448.9 nM (pChEMBL 4.170000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Spliceosome associated factor 3, U4/U6 recycling protein (SINGLE PROTEIN), Homo sapiens
UniProt: Q15020
Assay: Binding affinity to human SART3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 68448.9 nM (pChEMBL 4.170000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein salvador homolog 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9H4B6
Assay: Binding affinity to human SAV1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 308.55 nM (pChEMBL 6.510000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein salvador homolog 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9H4B6
Assay: Binding affinity to human SAV1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 355.96 nM (pChEMBL 6.449999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Ribosome maturation protein SBDS (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y3A5
Assay: Binding affinity to human SBDS incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 829.81 nM (pChEMBL 6.079999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Ribosome maturation protein SBDS (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y3A5
Assay: Binding affinity to human SBDS incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1718.94 nM (pChEMBL 5.760000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Secretory carrier-associated membrane protein 3 (SINGLE PROTEIN), Homo sapiens
UniProt: O14828
Assay: Binding affinity to human SCAMP3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1011.95 nM (pChEMBL 6)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Secretory carrier-associated membrane protein 3 (SINGLE PROTEIN), Homo sapiens
UniProt: O14828
Assay: Binding affinity to human SCAMP3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1011.95 nM (pChEMBL 6)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Stearoyl-CoA desaturase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q86SK9
Assay: Binding affinity to human SCD5 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1.275 nM (pChEMBL 8.890000343322754)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Stearoyl-CoA desaturase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q86SK9
Assay: Binding affinity to human SCD5 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1.275 nM (pChEMBL 8.890000343322754)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Selenocysteine lyase (SINGLE PROTEIN), Homo sapiens
UniProt: Q96I15
Assay: Binding affinity to human SCLY incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 890.7 nM (pChEMBL 6.050000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Selenocysteine lyase (SINGLE PROTEIN), Homo sapiens
UniProt: Q96I15
Assay: Binding affinity to human SCLY incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 890.7 nM (pChEMBL 6.050000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein SCO2 homolog, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: O43819
Assay: Binding affinity to human SCO2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 3042477.15 nM (pChEMBL 2.5199999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Sterol carrier protein 2 (SINGLE PROTEIN), Homo sapiens
UniProt: P22307
Assay: Binding affinity to human SCP2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 32462.6 nM (pChEMBL 4.489999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Sterol carrier protein 2 (SINGLE PROTEIN), Homo sapiens
UniProt: P22307
Assay: Binding affinity to human SCP2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 32462.6 nM (pChEMBL 4.489999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein SDA1 homolog (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NVU7
Assay: Binding affinity to human SDAD1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 0.852 nM (pChEMBL 9.069999694824219)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein SDA1 homolog (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NVU7
Assay: Binding affinity to human SDAD1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 0.949 nM (pChEMBL 9.020000457763672)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Syndecan-1 (SINGLE PROTEIN), Homo sapiens
UniProt: P18827
Assay: Binding affinity to human SDC1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 906.18 nM (pChEMBL 6.039999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Syndecan-1 (SINGLE PROTEIN), Homo sapiens
UniProt: P18827
Assay: Binding affinity to human SDC1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1069.6 nM (pChEMBL 5.96999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: P31040
Assay: Binding affinity to human SDHA incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2364.73 nM (pChEMBL 5.630000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: P31040
Assay: Binding affinity to human SDHA incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2364.73 nM (pChEMBL 5.630000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: P21912
Assay: Binding affinity to human SDHB incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 191271.49 nM (pChEMBL 3.7200000286102295)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Signal peptidase complex catalytic subunit SEC11A (SINGLE PROTEIN), Homo sapiens
UniProt: P67812
Assay: Binding affinity to human SEC11A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 6738.75 nM (pChEMBL 5.170000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Signal peptidase complex catalytic subunit SEC11A (SINGLE PROTEIN), Homo sapiens
UniProt: P67812
Assay: Binding affinity to human SEC11A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 6738.75 nM (pChEMBL 5.170000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein SEC13 homolog (SINGLE PROTEIN), Homo sapiens
UniProt: P55735
Assay: Binding affinity to human SEC13 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 4.933 nM (pChEMBL 8.3100004196167)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein SEC13 homolog (SINGLE PROTEIN), Homo sapiens
UniProt: P55735
Assay: Binding affinity to human SEC13 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 7.079 nM (pChEMBL 8.149999618530273)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein transport protein Sec16A (SINGLE PROTEIN), Homo sapiens
UniProt: O15027
Assay: Binding affinity to human SEC16A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 5.204 nM (pChEMBL 8.279999732971191)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein transport protein Sec16A (SINGLE PROTEIN), Homo sapiens
UniProt: O15027
Assay: Binding affinity to human SEC16A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 5.204 nM (pChEMBL 8.279999732971191)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32