lovingscience/chembl-v37-raw-activities huggingface dataset:
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Transaldolase (SINGLE PROTEIN), Homo sapiens
UniProt: P37837
Assay: Binding affinity to human TALDO1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 34354.3 nM (pChEMBL 4.460000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: TRAF family member-associated NF-kappa-B activator (SINGLE PROTEIN), Homo sapiens
UniProt: Q92844
Assay: Binding affinity to human TANK incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 8501.23 nM (pChEMBL 5.070000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: TRAF family member-associated NF-kappa-B activator (SINGLE PROTEIN), Homo sapiens
UniProt: Q92844
Assay: Binding affinity to human TANK incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 13362.93 nM (pChEMBL 4.869999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase TAO1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q7L7X3
Assay: Binding affinity to human TAOK1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 7421.77 nM (pChEMBL 5.130000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase TAO1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q7L7X3
Assay: Binding affinity to human TAOK1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 11163.76 nM (pChEMBL 4.949999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase TAO2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UL54
Assay: Binding affinity to human TAOK2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 14082.88 nM (pChEMBL 4.849999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase TAO2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UL54
Assay: Binding affinity to human TAOK2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 23884.93 nM (pChEMBL 4.619999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase TAO3 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9H2K8
Assay: Binding affinity to human TAOK3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 4522.3 nM (pChEMBL 5.340000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase TAO3 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9H2K8
Assay: Binding affinity to human TAOK3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 5845.39 nM (pChEMBL 5.230000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Antigen peptide transporter 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q03518
Assay: Binding affinity to human TAP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 63.85 nM (pChEMBL 7.199999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Antigen peptide transporter 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q03518
Assay: Binding affinity to human TAP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 63.85 nM (pChEMBL 7.199999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Antigen peptide transporter 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q03519
Assay: Binding affinity to human TAP2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 10291.01 nM (pChEMBL 4.989999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Antigen peptide transporter 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q03519
Assay: Binding affinity to human TAP2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 10291.01 nM (pChEMBL 4.989999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: tRNA (guanosine(18)-2'-O)-methyltransferase TARBP1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q13395
Assay: Binding affinity to human TARBP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 18371.81 nM (pChEMBL 4.739999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: tRNA (guanosine(18)-2'-O)-methyltransferase TARBP1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q13395
Assay: Binding affinity to human TARBP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 18371.81 nM (pChEMBL 4.739999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: TAR DNA-binding protein 43 (SINGLE PROTEIN), Homo sapiens
UniProt: Q13148
Assay: Binding affinity to human TARDBP incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 813.51 nM (pChEMBL 6.090000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: TAR DNA-binding protein 43 (SINGLE PROTEIN), Homo sapiens
UniProt: Q13148
Assay: Binding affinity to human TARDBP incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 813.51 nM (pChEMBL 6.090000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Threonine--tRNA ligase 1, cytoplasmic (SINGLE PROTEIN), Homo sapiens
UniProt: P26639
Assay: Binding affinity to human TARS incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 5.311 nM (pChEMBL 8.279999732971191)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Threonine--tRNA ligase 1, cytoplasmic (SINGLE PROTEIN), Homo sapiens
UniProt: P26639
Assay: Binding affinity to human TARS incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 5.311 nM (pChEMBL 8.279999732971191)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: TBC1 domain family member 15 (SINGLE PROTEIN), Homo sapiens
UniProt: Q8TC07
Assay: Binding affinity to human TBC1D15 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 624.05 nM (pChEMBL 6.210000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: TBC1 domain family member 15 (SINGLE PROTEIN), Homo sapiens
UniProt: Q8TC07
Assay: Binding affinity to human TBC1D15 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 828.57 nM (pChEMBL 6.079999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: TBC1 domain family member 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q92609
Assay: Binding affinity to human TBC1D5 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 23997.26 nM (pChEMBL 4.619999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: TBC1 domain family member 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q92609
Assay: Binding affinity to human TBC1D5 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 23997.26 nM (pChEMBL 4.619999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Tubulin-specific chaperone D (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BTW9
Assay: Binding affinity to human TBCD incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 4.589 nM (pChEMBL 8.34000015258789)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Tubulin-specific chaperone D (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BTW9
Assay: Binding affinity to human TBCD incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 4.589 nM (pChEMBL 8.34000015258789)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase TBK1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UHD2
Assay: Binding affinity to human TBK1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 11.99 nM (pChEMBL 7.920000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase TBK1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UHD2
Assay: Binding affinity to human TBK1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 18.75 nM (pChEMBL 7.730000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: TANK-binding kinase 1-binding protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: A7MCY6
Assay: Binding affinity to human TBKBP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 9065.05 nM (pChEMBL 5.039999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: TANK-binding kinase 1-binding protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: A7MCY6
Assay: Binding affinity to human TBKBP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 11422.76 nM (pChEMBL 4.940000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Elongin-C (SINGLE PROTEIN), Homo sapiens
UniProt: Q15369
Assay: Binding affinity to human TCEB1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 122110.35 nM (pChEMBL 3.9100000858306885)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Transcription elongation regulator 1 (SINGLE PROTEIN), Homo sapiens
UniProt: O14776
Assay: Binding affinity to human TCERG1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 732377.42 nM (pChEMBL 3.130000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: T-complex protein 1 subunit alpha (SINGLE PROTEIN), Homo sapiens
UniProt: P17987
Assay: Binding affinity to human TCP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 23.41 nM (pChEMBL 7.630000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: T-complex protein 1 subunit alpha (SINGLE PROTEIN), Homo sapiens
UniProt: P17987
Assay: Binding affinity to human TCP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 23.41 nM (pChEMBL 7.630000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Tyrosine-protein kinase Tec (SINGLE PROTEIN), Homo sapiens
UniProt: P42680
Assay: Binding affinity to human TEC incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 12.5 nM (pChEMBL 7.900000095367432)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Tyrosine-protein kinase Tec (SINGLE PROTEIN), Homo sapiens
UniProt: P42680
Assay: Binding affinity to human TEC incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 31.07 nM (pChEMBL 7.510000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Very-long-chain enoyl-CoA reductase (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NZ01
Assay: Binding affinity to human TECR incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 3863.2 nM (pChEMBL 5.409999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Very-long-chain enoyl-CoA reductase (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NZ01
Assay: Binding affinity to human TECR incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 3863.2 nM (pChEMBL 5.409999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Telomere length regulation protein TEL2 homolog (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y4R8
Assay: Binding affinity to human TELO2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 664.82 nM (pChEMBL 6.179999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Telomere length regulation protein TEL2 homolog (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y4R8
Assay: Binding affinity to human TELO2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 664.82 nM (pChEMBL 6.179999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Dual specificity testis-specific protein kinase 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q96S53
Assay: Binding affinity to human TESK2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 0.772 nM (pChEMBL 9.109999656677246)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Dual specificity testis-specific protein kinase 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q96S53
Assay: Binding affinity to human TESK2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1.364 nM (pChEMBL 8.869999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Testis-expressed protein 264 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y6I9
Assay: Binding affinity to human TEX264 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 4955.6 nM (pChEMBL 5.300000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Testis-expressed protein 264 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y6I9
Assay: Binding affinity to human TEX264 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 5044.34 nM (pChEMBL 5.300000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Transcription factor A, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: Q00059
Assay: Binding affinity to human TFAM incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 17018.59 nM (pChEMBL 4.769999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Transcription factor A, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: Q00059
Assay: Binding affinity to human TFAM incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 17018.59 nM (pChEMBL 4.769999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Transferrin receptor protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: P02786
Assay: Binding affinity to human TFRC incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 100.29 nM (pChEMBL 7)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Transferrin receptor protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: P02786
Assay: Binding affinity to human TFRC incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 100.29 nM (pChEMBL 7)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: TGF-beta receptor type-1 (SINGLE PROTEIN), Homo sapiens
UniProt: P36897
Assay: Binding affinity to human TGFBR1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 0.266 nM (pChEMBL 9.569999694824219)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: TGF-beta receptor type-1 (SINGLE PROTEIN), Homo sapiens
UniProt: P36897
Assay: Binding affinity to human TGFBR1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 0.384 nM (pChEMBL 9.420000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: TGF-beta receptor type-2 (SINGLE PROTEIN), Homo sapiens
UniProt: P37173
Assay: Binding affinity to human TGFBR2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 26692.33 nM (pChEMBL 4.570000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: TGF-beta receptor type-2 (SINGLE PROTEIN), Homo sapiens
UniProt: P37173
Assay: Binding affinity to human TGFBR2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 35480.21 nM (pChEMBL 4.449999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Protein THEM6 (SINGLE PROTEIN), Homo sapiens
UniProt: Q8WUY1
Assay: Binding affinity to human THEM6 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1695.92 nM (pChEMBL 5.769999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Protein THEM6 (SINGLE PROTEIN), Homo sapiens
UniProt: Q8WUY1
Assay: Binding affinity to human THEM6 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1695.92 nM (pChEMBL 5.769999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: THO complex subunit 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q8NI27
Assay: Binding affinity to human THOC2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 8402.38 nM (pChEMBL 5.079999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: THO complex subunit 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q8NI27
Assay: Binding affinity to human THOC2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 8402.38 nM (pChEMBL 5.079999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: THUMP domain-containing protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NXG2
Assay: Binding affinity to human THUMPD1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 100631.59 nM (pChEMBL 4)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Nucleolysin TIAR (SINGLE PROTEIN), Homo sapiens
UniProt: Q01085
Assay: Binding affinity to human TIAL1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 799.25 nM (pChEMBL 6.099999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Nucleolysin TIAR (SINGLE PROTEIN), Homo sapiens
UniProt: Q01085
Assay: Binding affinity to human TIAL1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 933.98 nM (pChEMBL 6.03000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Mitochondrial import inner membrane translocase subunit TIM44 (SINGLE PROTEIN), Homo sapiens
UniProt: O43615
Assay: Binding affinity to human TIMM44 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 444.99 nM (pChEMBL 6.349999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Mitochondrial import inner membrane translocase subunit TIM44 (SINGLE PROTEIN), Homo sapiens
UniProt: O43615
Assay: Binding affinity to human TIMM44 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 444.99 nM (pChEMBL 6.349999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Mitochondrial import inner membrane translocase subunit TIM50 (SINGLE PROTEIN), Homo sapiens
UniProt: Q3ZCQ8
Assay: Binding affinity to human TIMM50 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 3587.88 nM (pChEMBL 5.449999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Mitochondrial import inner membrane translocase subunit TIM50 (SINGLE PROTEIN), Homo sapiens
UniProt: Q3ZCQ8
Assay: Binding affinity to human TIMM50 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 3587.88 nM (pChEMBL 5.449999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Transketolase (SINGLE PROTEIN), Homo sapiens
UniProt: P29401
Assay: Binding affinity to human TKT incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 166.94 nM (pChEMBL 6.78000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Transketolase (SINGLE PROTEIN), Homo sapiens
UniProt: P29401
Assay: Binding affinity to human TKT incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 166.94 nM (pChEMBL 6.78000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Transmembrane 9 superfamily member 3 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9HD45
Assay: Binding affinity to human TM9SF3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 4216.83 nM (pChEMBL 5.380000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Transmembrane 9 superfamily member 3 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9HD45
Assay: Binding affinity to human TM9SF3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 4216.83 nM (pChEMBL 5.380000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Transmembrane 9 superfamily member 4 (SINGLE PROTEIN), Homo sapiens
UniProt: Q92544
Assay: Binding affinity to human TM9SF4 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 9652.4 nM (pChEMBL 5.010000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Transmembrane 9 superfamily member 4 (SINGLE PROTEIN), Homo sapiens
UniProt: Q92544
Assay: Binding affinity to human TM9SF4 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 9652.4 nM (pChEMBL 5.010000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Calcium load-activated calcium channel (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UM00
Assay: Binding affinity to human TMCO1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 21.93 nM (pChEMBL 7.659999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Calcium load-activated calcium channel (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UM00
Assay: Binding affinity to human TMCO1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 21.93 nM (pChEMBL 7.659999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Transmembrane emp24 domain-containing protein 9 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BVK6
Assay: Binding affinity to human TMED9 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 67939.49 nM (pChEMBL 4.170000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Transmembrane emp24 domain-containing protein 9 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BVK6
Assay: Binding affinity to human TMED9 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 67939.49 nM (pChEMBL 4.170000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Transmembrane protein 161A (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NX61
Assay: Binding affinity to human TMEM161A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 44.02 nM (pChEMBL 7.360000133514404)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Transmembrane protein 161A (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NX61
Assay: Binding affinity to human TMEM161A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 44.02 nM (pChEMBL 7.360000133514404)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Putative divalent cation/proton antiporter TMEM165 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9HC07
Assay: Binding affinity to human TMEM165 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 8831.65 nM (pChEMBL 5.050000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Putative divalent cation/proton antiporter TMEM165 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9HC07
Assay: Binding affinity to human TMEM165 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 8831.65 nM (pChEMBL 5.050000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Transmembrane protein 33 (SINGLE PROTEIN), Homo sapiens
UniProt: P57088
Assay: Binding affinity to human TMEM33 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 4888.69 nM (pChEMBL 5.309999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Transmembrane protein 33 (SINGLE PROTEIN), Homo sapiens
UniProt: P57088
Assay: Binding affinity to human TMEM33 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 4888.69 nM (pChEMBL 5.309999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Transmembrane protein 43 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BTV4
Assay: Binding affinity to human TMEM43 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 6.152 nM (pChEMBL 8.210000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Transmembrane protein 43 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BTV4
Assay: Binding affinity to human TMEM43 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 6.152 nM (pChEMBL 8.210000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Lamina-associated polypeptide 2, isoform alpha (SINGLE PROTEIN), Homo sapiens
UniProt: P42166
Assay: Binding affinity to human TMPO (P42166) incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 3348.44 nM (pChEMBL 5.46999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Lamina-associated polypeptide 2, isoform alpha (SINGLE PROTEIN), Homo sapiens
UniProt: P42166
Assay: Binding affinity to human TMPO (P42166) incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 3348.44 nM (pChEMBL 5.46999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Thioredoxin-related transmembrane protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9H3N1
Assay: Binding affinity to human TMX1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 219343.36 nM (pChEMBL 3.6600000858306885)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: TRAF2 and NCK-interacting protein kinase (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UKE5
Assay: Binding affinity to human TNIK incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 23170.68 nM (pChEMBL 4.630000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: TRAF2 and NCK-interacting protein kinase (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UKE5
Assay: Binding affinity to human TNIK incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 23170.68 nM (pChEMBL 4.630000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Non-receptor tyrosine-protein kinase TNK1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q13470
Assay: Binding affinity to human TNK1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 8152.88 nM (pChEMBL 5.090000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Non-receptor tyrosine-protein kinase TNK1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q13470
Assay: Binding affinity to human TNK1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 18846.37 nM (pChEMBL 4.71999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Activated CDC42 kinase 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q07912
Assay: Binding affinity to human TNK2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 985.03 nM (pChEMBL 6.010000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Activated CDC42 kinase 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q07912
Assay: Binding affinity to human TNK2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2188.17 nM (pChEMBL 5.659999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Transportin-1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q92973
Assay: Binding affinity to human TNPO1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 3813.6 nM (pChEMBL 5.420000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Transportin-1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q92973
Assay: Binding affinity to human TNPO1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 3813.6 nM (pChEMBL 5.420000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Transportin-3 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y5L0
Assay: Binding affinity to human TNPO3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 18994.22 nM (pChEMBL 4.71999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Transportin-3 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y5L0
Assay: Binding affinity to human TNPO3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 18994.22 nM (pChEMBL 4.71999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: DNA topoisomerase 1 (SINGLE PROTEIN), Homo sapiens
UniProt: P11387
Assay: Binding affinity to human TOP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 42.49 nM (pChEMBL 7.369999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: DNA topoisomerase 1 (SINGLE PROTEIN), Homo sapiens
UniProt: P11387
Assay: Binding affinity to human TOP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 42.49 nM (pChEMBL 7.369999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: DNA topoisomerase 2-alpha (SINGLE PROTEIN), Homo sapiens
UniProt: P11388
Assay: Binding affinity to human TOP2A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 54.1 nM (pChEMBL 7.269999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: DNA topoisomerase 2-alpha (SINGLE PROTEIN), Homo sapiens
UniProt: P11388
Assay: Binding affinity to human TOP2A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 56.25 nM (pChEMBL 7.25)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: DNA topoisomerase 2-beta (SINGLE PROTEIN), Homo sapiens
UniProt: Q02880
Assay: Binding affinity to human TOP2B incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 3180.07 nM (pChEMBL 5.5)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: DNA topoisomerase 2-beta (SINGLE PROTEIN), Homo sapiens
UniProt: Q02880
Assay: Binding affinity to human TOP2B incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 3180.07 nM (pChEMBL 5.5)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: EKC/KEOPS complex subunit TP53RK (SINGLE PROTEIN), Homo sapiens
UniProt: Q96S44
Assay: Binding affinity to human TP53RK incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 3471.48 nM (pChEMBL 5.460000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: EKC/KEOPS complex subunit TP53RK (SINGLE PROTEIN), Homo sapiens
UniProt: Q96S44
Assay: Binding affinity to human TP53RK incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 3471.48 nM (pChEMBL 5.460000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Triosephosphate isomerase (SINGLE PROTEIN), Homo sapiens
UniProt: P60174
Assay: Binding affinity to human TPI1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 182.66 nM (pChEMBL 6.739999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Triosephosphate isomerase (SINGLE PROTEIN), Homo sapiens
UniProt: P60174
Assay: Binding affinity to human TPI1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 182.66 nM (pChEMBL 6.739999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Tropomyosin alpha-3 chain (SINGLE PROTEIN), Homo sapiens
UniProt: P06753
Assay: Binding affinity to human TPM3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 5570.5 nM (pChEMBL 5.25)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Tropomyosin alpha-3 chain (SINGLE PROTEIN), Homo sapiens
UniProt: P06753
Assay: Binding affinity to human TPM3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 5570.5 nM (pChEMBL 5.25)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Tripeptidyl-peptidase 1 (SINGLE PROTEIN), Homo sapiens
UniProt: O14773
Assay: Binding affinity to human TPP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 3389.26 nM (pChEMBL 5.46999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Tripeptidyl-peptidase 1 (SINGLE PROTEIN), Homo sapiens
UniProt: O14773
Assay: Binding affinity to human TPP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 3389.26 nM (pChEMBL 5.46999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Tripeptidyl-peptidase 2 (SINGLE PROTEIN), Homo sapiens
UniProt: P29144
Assay: Binding affinity to human TPP2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 53798.29 nM (pChEMBL 4.269999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Tripeptidyl-peptidase 2 (SINGLE PROTEIN), Homo sapiens
UniProt: P29144
Assay: Binding affinity to human TPP2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 53798.29 nM (pChEMBL 4.269999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Nucleoprotein TPR (SINGLE PROTEIN), Homo sapiens
UniProt: P12270
Assay: Binding affinity to human TPR incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 10371.64 nM (pChEMBL 4.980000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Nucleoprotein TPR (SINGLE PROTEIN), Homo sapiens
UniProt: P12270
Assay: Binding affinity to human TPR incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 10371.64 nM (pChEMBL 4.980000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: EKC/KEOPS complex subunit TPRKB (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y3C4
Assay: Binding affinity to human TPRKB incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 32641.53 nM (pChEMBL 4.489999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: EKC/KEOPS complex subunit TPRKB (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y3C4
Assay: Binding affinity to human TPRKB incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 34475.73 nM (pChEMBL 4.460000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Transformer-2 protein homolog beta (SINGLE PROTEIN), Homo sapiens
UniProt: P62995
Assay: Binding affinity to human TRA2B incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 12.12 nM (pChEMBL 7.920000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32