lovingscience/chembl-v37-raw-activities huggingface dataset:
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Prothymosin alpha (SINGLE PROTEIN), Homo sapiens
UniProt: P06454
Assay: Binding affinity to human PTMA incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 11096.91 nM (pChEMBL 4.960000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Poly(U)-binding-splicing factor PUF60 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UHX1
Assay: Binding affinity to human PUF60 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 11047.7 nM (pChEMBL 4.960000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Poly(U)-binding-splicing factor PUF60 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UHX1
Assay: Binding affinity to human PUF60 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 11047.7 nM (pChEMBL 4.960000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Transcriptional regulator protein Pur-beta (SINGLE PROTEIN), Homo sapiens
UniProt: Q96QR8
Assay: Binding affinity to human PURB incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 7.964 nM (pChEMBL 8.100000381469727)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Transcriptional regulator protein Pur-beta (SINGLE PROTEIN), Homo sapiens
UniProt: Q96QR8
Assay: Binding affinity to human PURB incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 7.964 nM (pChEMBL 8.100000381469727)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Glycogen phosphorylase, brain form (SINGLE PROTEIN), Homo sapiens
UniProt: P11216
Assay: Binding affinity to human PYGB incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 39.46 nM (pChEMBL 7.400000095367432)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Glycogen phosphorylase, brain form (SINGLE PROTEIN), Homo sapiens
UniProt: P11216
Assay: Binding affinity to human PYGB incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 39.46 nM (pChEMBL 7.400000095367432)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Glycogen phosphorylase, liver form (SINGLE PROTEIN), Homo sapiens
UniProt: P06737
Assay: Binding affinity to human PYGL incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2.394 nM (pChEMBL 8.619999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Glycogen phosphorylase, liver form (SINGLE PROTEIN), Homo sapiens
UniProt: P06737
Assay: Binding affinity to human PYGL incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2.394 nM (pChEMBL 8.619999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Uncharacterized protein FLJ45252 (SINGLE PROTEIN), Homo sapiens
UniProt: Q6ZSR9
Assay: Binding affinity to human FLJ45252 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 189.08 nM (pChEMBL 6.71999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Uncharacterized protein FLJ45252 (SINGLE PROTEIN), Homo sapiens
UniProt: Q6ZSR9
Assay: Binding affinity to human FLJ45252 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 248.31 nM (pChEMBL 6.610000133514404)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Glutamine--tRNA ligase (SINGLE PROTEIN), Homo sapiens
UniProt: P47897
Assay: Binding affinity to human QARS incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 106.8 nM (pChEMBL 6.96999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Glutamine--tRNA ligase (SINGLE PROTEIN), Homo sapiens
UniProt: P47897
Assay: Binding affinity to human QARS incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 106.8 nM (pChEMBL 6.96999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ras-related protein Rab-10 (SINGLE PROTEIN), Homo sapiens
UniProt: P61026
Assay: Binding affinity to human RAB10 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 846.41 nM (pChEMBL 6.070000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ras-related protein Rab-10 (SINGLE PROTEIN), Homo sapiens
UniProt: P61026
Assay: Binding affinity to human RAB10 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 846.41 nM (pChEMBL 6.070000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ras-related protein Rab-14 (SINGLE PROTEIN), Homo sapiens
UniProt: P61106
Assay: Binding affinity to human RAB14 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2882.31 nM (pChEMBL 5.539999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ras-related protein Rab-14 (SINGLE PROTEIN), Homo sapiens
UniProt: P61106
Assay: Binding affinity to human RAB14 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2882.31 nM (pChEMBL 5.539999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ras-related protein Rab-5B (SINGLE PROTEIN), Homo sapiens
UniProt: P61020
Assay: Binding affinity to human RAB5B incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 18071.45 nM (pChEMBL 4.739999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ras-related protein Rab-5B (SINGLE PROTEIN), Homo sapiens
UniProt: P61020
Assay: Binding affinity to human RAB5B incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 18071.45 nM (pChEMBL 4.739999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ras-related protein Rab-5C (SINGLE PROTEIN), Homo sapiens
UniProt: P51148
Assay: Binding affinity to human RAB5C incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 19185.11 nM (pChEMBL 4.71999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ras-related protein Rab-5C (SINGLE PROTEIN), Homo sapiens
UniProt: P51148
Assay: Binding affinity to human RAB5C incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 19185.11 nM (pChEMBL 4.71999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ras-related protein Rab-6A (SINGLE PROTEIN), Homo sapiens
UniProt: P20340
Assay: Binding affinity to human RAB6A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 34132.41 nM (pChEMBL 4.46999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ras-related protein Rab-6A (SINGLE PROTEIN), Homo sapiens
UniProt: P20340
Assay: Binding affinity to human RAB6A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 34132.41 nM (pChEMBL 4.46999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ras-related protein Rab-7a (SINGLE PROTEIN), Homo sapiens
UniProt: P51149
Assay: Binding affinity to human RAB7A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 6592.35 nM (pChEMBL 5.179999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ras-related protein Rab-7a (SINGLE PROTEIN), Homo sapiens
UniProt: P51149
Assay: Binding affinity to human RAB7A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 6592.35 nM (pChEMBL 5.179999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ras-related protein Rab-8A (SINGLE PROTEIN), Homo sapiens
UniProt: P61006
Assay: Binding affinity to human RAB8A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 23301.2 nM (pChEMBL 4.630000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ras-related protein Rab-8A (SINGLE PROTEIN), Homo sapiens
UniProt: P61006
Assay: Binding affinity to human RAB8A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 23301.2 nM (pChEMBL 4.630000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Rab-like protein 3 (SINGLE PROTEIN), Homo sapiens
UniProt: Q5HYI8
Assay: Binding affinity to human RABL3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 4027.26 nM (pChEMBL 5.389999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Rab-like protein 3 (SINGLE PROTEIN), Homo sapiens
UniProt: Q5HYI8
Assay: Binding affinity to human RABL3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 4037.38 nM (pChEMBL 5.389999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: UV excision repair protein RAD23 homolog B (SINGLE PROTEIN), Homo sapiens
UniProt: P54727
Assay: Binding affinity to human RAD23B incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2.593 nM (pChEMBL 8.59000015258789)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: UV excision repair protein RAD23 homolog B (SINGLE PROTEIN), Homo sapiens
UniProt: P54727
Assay: Binding affinity to human RAD23B incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2.593 nM (pChEMBL 8.59000015258789)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: DNA repair protein RAD50 (SINGLE PROTEIN), Homo sapiens
UniProt: Q92878
Assay: Binding affinity to human RAD50 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 8820.83 nM (pChEMBL 5.050000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: DNA repair protein RAD50 (SINGLE PROTEIN), Homo sapiens
UniProt: Q92878
Assay: Binding affinity to human RAD50 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 8820.83 nM (pChEMBL 5.050000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: GTP-binding nuclear protein Ran (SINGLE PROTEIN), Homo sapiens
UniProt: P62826
Assay: Binding affinity to human RAN incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 4291.73 nM (pChEMBL 5.369999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: GTP-binding nuclear protein Ran (SINGLE PROTEIN), Homo sapiens
UniProt: P62826
Assay: Binding affinity to human RAN incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 4291.73 nM (pChEMBL 5.369999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ran-specific GTPase-activating protein (SINGLE PROTEIN), Homo sapiens
UniProt: P43487
Assay: Binding affinity to human RANBP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 3627.52 nM (pChEMBL 5.440000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ran-specific GTPase-activating protein (SINGLE PROTEIN), Homo sapiens
UniProt: P43487
Assay: Binding affinity to human RANBP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 3627.52 nM (pChEMBL 5.440000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Arginine--tRNA ligase, cytoplasmic (SINGLE PROTEIN), Homo sapiens
UniProt: P54136
Assay: Binding affinity to human RARS incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 886.46 nM (pChEMBL 6.050000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Arginine--tRNA ligase, cytoplasmic (SINGLE PROTEIN), Homo sapiens
UniProt: P54136
Assay: Binding affinity to human RARS incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 886.46 nM (pChEMBL 6.050000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ras association domain-containing protein 2 (SINGLE PROTEIN), Homo sapiens
UniProt: P50749
Assay: Binding affinity to human RASSF2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 15.26 nM (pChEMBL 7.820000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ras association domain-containing protein 2 (SINGLE PROTEIN), Homo sapiens
UniProt: P50749
Assay: Binding affinity to human RASSF2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 16.43 nM (pChEMBL 7.78000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ras association domain-containing protein 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q8WWW0
Assay: Binding affinity to human RASSF5 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 6302.07 nM (pChEMBL 5.199999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ras association domain-containing protein 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q8WWW0
Assay: Binding affinity to human RASSF5 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 6409.8 nM (pChEMBL 5.190000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Histone-binding protein RBBP4 (SINGLE PROTEIN), Homo sapiens
UniProt: Q09028
Assay: Binding affinity to human RBBP4 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 11020.97 nM (pChEMBL 4.960000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Histone-binding protein RBBP4 (SINGLE PROTEIN), Homo sapiens
UniProt: Q09028
Assay: Binding affinity to human RBBP4 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 11020.97 nM (pChEMBL 4.960000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: RNA-binding protein 14 (SINGLE PROTEIN), Homo sapiens
UniProt: Q96PK6
Assay: Binding affinity to human RBM14 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 12431.35 nM (pChEMBL 4.909999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: RNA-binding protein 14 (SINGLE PROTEIN), Homo sapiens
UniProt: Q96PK6
Assay: Binding affinity to human RBM14 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 12431.35 nM (pChEMBL 4.909999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: RNA-binding protein 28 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NW13
Assay: Binding affinity to human RBM28 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 21.04 nM (pChEMBL 7.679999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: RNA-binding protein 28 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NW13
Assay: Binding affinity to human RBM28 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 21.04 nM (pChEMBL 7.679999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: RNA-binding protein 3 (SINGLE PROTEIN), Homo sapiens
UniProt: P98179
Assay: Binding affinity to human RBM3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 13472.78 nM (pChEMBL 4.869999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: RNA-binding protein 3 (SINGLE PROTEIN), Homo sapiens
UniProt: P98179
Assay: Binding affinity to human RBM3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 13472.78 nM (pChEMBL 4.869999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Protein RCC2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9P258
Assay: Binding affinity to human RCC2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 92222.24 nM (pChEMBL 4.039999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Protein RCC2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9P258
Assay: Binding affinity to human RCC2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 92222.24 nM (pChEMBL 4.039999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Radixin (SINGLE PROTEIN), Homo sapiens
UniProt: P35241
Assay: Binding affinity to human RDX incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2.002 nM (pChEMBL 8.699999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Radixin (SINGLE PROTEIN), Homo sapiens
UniProt: P35241
Assay: Binding affinity to human RDX incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2.002 nM (pChEMBL 8.699999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: ATP-dependent DNA helicase Q1 (SINGLE PROTEIN), Homo sapiens
UniProt: P46063
Assay: Binding affinity to human RECQL incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 28.13 nM (pChEMBL 7.550000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: ATP-dependent DNA helicase Q1 (SINGLE PROTEIN), Homo sapiens
UniProt: P46063
Assay: Binding affinity to human RECQL incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 30.43 nM (pChEMBL 7.519999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Protein RER1 (SINGLE PROTEIN), Homo sapiens
UniProt: O15258
Assay: Binding affinity to human RER1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 78160.46 nM (pChEMBL 4.110000133514404)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Protein RER1 (SINGLE PROTEIN), Homo sapiens
UniProt: O15258
Assay: Binding affinity to human RER1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 78160.46 nM (pChEMBL 4.110000133514404)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Proto-oncogene tyrosine-protein kinase receptor Ret (SINGLE PROTEIN), Homo sapiens
UniProt: P07949
Assay: Binding affinity to human RET incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2252.18 nM (pChEMBL 5.650000095367432)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Proto-oncogene tyrosine-protein kinase receptor Ret (SINGLE PROTEIN), Homo sapiens
UniProt: P07949
Assay: Binding affinity to human RET incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 5111.98 nM (pChEMBL 5.289999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Replication factor C subunit 3 (SINGLE PROTEIN), Homo sapiens
UniProt: P40938
Assay: Binding affinity to human RFC3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 484.66 nM (pChEMBL 6.320000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Replication factor C subunit 3 (SINGLE PROTEIN), Homo sapiens
UniProt: P40938
Assay: Binding affinity to human RFC3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 484.66 nM (pChEMBL 6.320000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Replication factor C subunit 5 (SINGLE PROTEIN), Homo sapiens
UniProt: P40937
Assay: Binding affinity to human RFC5 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 584.1 nM (pChEMBL 6.230000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Replication factor C subunit 5 (SINGLE PROTEIN), Homo sapiens
UniProt: P40937
Assay: Binding affinity to human RFC5 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 584.1 nM (pChEMBL 6.230000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q96AA3
Assay: Binding affinity to human RFT1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1126.14 nM (pChEMBL 5.949999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Man(5)GlcNAc(2)-PP-dolichol translocation protein RFT1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q96AA3
Assay: Binding affinity to human RFT1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1126.14 nM (pChEMBL 5.949999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Mitochondrial Rho GTPase 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q8IXI1
Assay: Binding affinity to human RHOT2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1136.44 nM (pChEMBL 5.940000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Mitochondrial Rho GTPase 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q8IXI1
Assay: Binding affinity to human RHOT2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1136.44 nM (pChEMBL 5.940000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Rapamycin-insensitive companion of mTOR (SINGLE PROTEIN), Homo sapiens
UniProt: Q6R327
Assay: Binding affinity to human RICTOR incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 10142.64 nM (pChEMBL 4.989999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Rapamycin-insensitive companion of mTOR (SINGLE PROTEIN), Homo sapiens
UniProt: Q6R327
Assay: Binding affinity to human RICTOR incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 10142.64 nM (pChEMBL 4.989999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Receptor-interacting serine/threonine-protein kinase 2 (SINGLE PROTEIN), Homo sapiens
UniProt: O43353
Assay: Binding affinity to human RIPK2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 8285.67 nM (pChEMBL 5.079999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Receptor-interacting serine/threonine-protein kinase 2 (SINGLE PROTEIN), Homo sapiens
UniProt: O43353
Assay: Binding affinity to human RIPK2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 29526.5 nM (pChEMBL 4.53000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Receptor-interacting serine/threonine-protein kinase 3 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y572
Assay: Binding affinity to human RIPK3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2462.81 nM (pChEMBL 5.610000133514404)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Receptor-interacting serine/threonine-protein kinase 3 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y572
Assay: Binding affinity to human RIPK3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2754.27 nM (pChEMBL 5.559999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: E3 ubiquitin-protein ligase RNF213 (SINGLE PROTEIN), Homo sapiens
UniProt: Q63HN8
Assay: Binding affinity to human RNF213 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 53781.4 nM (pChEMBL 4.269999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: E3 ubiquitin-protein ligase RNF213 (SINGLE PROTEIN), Homo sapiens
UniProt: Q63HN8
Assay: Binding affinity to human RNF213 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 53781.4 nM (pChEMBL 4.269999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ribonuclease H1 (SINGLE PROTEIN), Homo sapiens
UniProt: O60930
Assay: Binding affinity to human RNH1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 12738.84 nM (pChEMBL 4.889999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Ribonuclease H1 (SINGLE PROTEIN), Homo sapiens
UniProt: O60930
Assay: Binding affinity to human RNH1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 12738.84 nM (pChEMBL 4.889999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Aminopeptidase B (SINGLE PROTEIN), Homo sapiens
UniProt: Q9H4A4
Assay: Binding affinity to human RNPEP incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 664.06 nM (pChEMBL 6.179999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Aminopeptidase B (SINGLE PROTEIN), Homo sapiens
UniProt: Q9H4A4
Assay: Binding affinity to human RNPEP incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 664.06 nM (pChEMBL 6.179999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Rho-associated protein kinase 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q13464
Assay: Binding affinity to human ROCK1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 9979.94 nM (pChEMBL 5)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Rho-associated protein kinase 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q13464
Assay: Binding affinity to human ROCK1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 10974.88 nM (pChEMBL 4.960000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Rho-associated protein kinase 2 (SINGLE PROTEIN), Homo sapiens
UniProt: O75116
Assay: Binding affinity to human ROCK2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 17.51 nM (pChEMBL 7.760000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Rho-associated protein kinase 2 (SINGLE PROTEIN), Homo sapiens
UniProt: O75116
Assay: Binding affinity to human ROCK2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 20.08 nM (pChEMBL 7.699999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL16 (SINGLE PROTEIN), Homo sapiens
UniProt: P27635
Assay: Binding affinity to human RPL10 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 76.75 nM (pChEMBL 7.119999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL16 (SINGLE PROTEIN), Homo sapiens
UniProt: P27635
Assay: Binding affinity to human RPL10 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 76.75 nM (pChEMBL 7.119999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL1 (SINGLE PROTEIN), Homo sapiens
UniProt: P62906
Assay: Binding affinity to human RPL10A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 577.27 nM (pChEMBL 6.239999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL1 (SINGLE PROTEIN), Homo sapiens
UniProt: P62906
Assay: Binding affinity to human RPL10A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 577.27 nM (pChEMBL 6.239999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL5 (SINGLE PROTEIN), Homo sapiens
UniProt: P62913
Assay: Binding affinity to human RPL11 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 39.54 nM (pChEMBL 7.400000095367432)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL5 (SINGLE PROTEIN), Homo sapiens
UniProt: P62913
Assay: Binding affinity to human RPL11 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 39.54 nM (pChEMBL 7.400000095367432)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL11 (SINGLE PROTEIN), Homo sapiens
UniProt: P30050
Assay: Binding affinity to human RPL12 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 3627.74 nM (pChEMBL 5.440000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL11 (SINGLE PROTEIN), Homo sapiens
UniProt: P30050
Assay: Binding affinity to human RPL12 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 3627.74 nM (pChEMBL 5.440000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL13 (SINGLE PROTEIN), Homo sapiens
UniProt: P26373
Assay: Binding affinity to human RPL13 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 13940.23 nM (pChEMBL 4.860000133514404)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL13 (SINGLE PROTEIN), Homo sapiens
UniProt: P26373
Assay: Binding affinity to human RPL13 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 13940.23 nM (pChEMBL 4.860000133514404)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL14 (SINGLE PROTEIN), Homo sapiens
UniProt: P50914
Assay: Binding affinity to human RPL14 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 186.6 nM (pChEMBL 6.730000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL14 (SINGLE PROTEIN), Homo sapiens
UniProt: P50914
Assay: Binding affinity to human RPL14 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 186.6 nM (pChEMBL 6.730000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL15 (SINGLE PROTEIN), Homo sapiens
UniProt: P61313
Assay: Binding affinity to human RPL15 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 424.77 nM (pChEMBL 6.369999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL15 (SINGLE PROTEIN), Homo sapiens
UniProt: P61313
Assay: Binding affinity to human RPL15 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 424.77 nM (pChEMBL 6.369999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL22 (SINGLE PROTEIN), Homo sapiens
UniProt: P18621
Assay: Binding affinity to human RPL17 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 6614.55 nM (pChEMBL 5.179999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL22 (SINGLE PROTEIN), Homo sapiens
UniProt: P18621
Assay: Binding affinity to human RPL17 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 6614.55 nM (pChEMBL 5.179999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL20 (SINGLE PROTEIN), Homo sapiens
UniProt: Q02543
Assay: Binding affinity to human RPL18A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 98.14 nM (pChEMBL 7.010000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL20 (SINGLE PROTEIN), Homo sapiens
UniProt: Q02543
Assay: Binding affinity to human RPL18A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 98.14 nM (pChEMBL 7.010000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL19 (SINGLE PROTEIN), Homo sapiens
UniProt: P84098
Assay: Binding affinity to human RPL19 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2932.64 nM (pChEMBL 5.53000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL19 (SINGLE PROTEIN), Homo sapiens
UniProt: P84098
Assay: Binding affinity to human RPL19 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2932.64 nM (pChEMBL 5.53000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL21 (SINGLE PROTEIN), Homo sapiens
UniProt: P46778
Assay: Binding affinity to human RPL21 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1642.9 nM (pChEMBL 5.78000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL21 (SINGLE PROTEIN), Homo sapiens
UniProt: P46778
Assay: Binding affinity to human RPL21 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1642.9 nM (pChEMBL 5.78000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL22 (SINGLE PROTEIN), Homo sapiens
UniProt: P35268
Assay: Binding affinity to human RPL22 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 784120.63 nM (pChEMBL 3.109999895095825)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL14 (SINGLE PROTEIN), Homo sapiens
UniProt: P62829
Assay: Binding affinity to human RPL23 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 11685.65 nM (pChEMBL 4.929999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL14 (SINGLE PROTEIN), Homo sapiens
UniProt: P62829
Assay: Binding affinity to human RPL23 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 11685.65 nM (pChEMBL 4.929999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL23 (SINGLE PROTEIN), Homo sapiens
UniProt: P62750
Assay: Binding affinity to human RPL23A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 104.86 nM (pChEMBL 6.980000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL23 (SINGLE PROTEIN), Homo sapiens
UniProt: P62750
Assay: Binding affinity to human RPL23A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 104.86 nM (pChEMBL 6.980000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL24 (SINGLE PROTEIN), Homo sapiens
UniProt: P83731
Assay: Binding affinity to human RPL24 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 10331.31 nM (pChEMBL 4.989999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2c1cnn2C
InChIKey: ZCCPLJOKGAACRT-UHFFFAOYSA-N
Target: Large ribosomal subunit protein eL24 (SINGLE PROTEIN), Homo sapiens
UniProt: P83731
Assay: Binding affinity to human RPL24 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 10331.31 nM (pChEMBL 4.989999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32