lovingscience/chembl-v37-raw-activities huggingface dataset:
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Mannose-P-dolichol utilization defect 1 protein (SINGLE PROTEIN), Homo sapiens
UniProt: O75352
Assay: Binding affinity to human MPDU1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 60.8 nM (pChEMBL 7.21999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: M-phase phosphoprotein 6 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99547
Assay: Binding affinity to human MPHOSPH6 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 7.206 nM (pChEMBL 8.140000343322754)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: M-phase phosphoprotein 6 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99547
Assay: Binding affinity to human MPHOSPH6 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 7.206 nM (pChEMBL 8.140000343322754)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 3-mercaptopyruvate sulfurtransferase (SINGLE PROTEIN), Homo sapiens
UniProt: P25325
Assay: Binding affinity to human MPST incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 54343.2 nM (pChEMBL 4.260000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 3-mercaptopyruvate sulfurtransferase (SINGLE PROTEIN), Homo sapiens
UniProt: P25325
Assay: Binding affinity to human MPST incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 58867.51 nM (pChEMBL 4.230000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Double-strand break repair protein MRE11 (SINGLE PROTEIN), Homo sapiens
UniProt: P49959
Assay: Binding affinity to human MRE11A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 14887.26 nM (pChEMBL 4.829999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Double-strand break repair protein MRE11 (SINGLE PROTEIN), Homo sapiens
UniProt: P49959
Assay: Binding affinity to human MRE11A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 14887.26 nM (pChEMBL 4.829999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: rRNA methyltransferase 1, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: Q6IN84
Assay: Binding affinity to human MRM1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 56.87 nM (pChEMBL 7.25)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: rRNA methyltransferase 1, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: Q6IN84
Assay: Binding affinity to human MRM1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 56.87 nM (pChEMBL 7.25)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL11m (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y3B7
Assay: Binding affinity to human MRPL11 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 76 nM (pChEMBL 7.119999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein uL11m (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y3B7
Assay: Binding affinity to human MRPL11 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 76 nM (pChEMBL 7.119999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein bL12m (SINGLE PROTEIN), Homo sapiens
UniProt: P52815
Assay: Binding affinity to human MRPL12 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 116.57 nM (pChEMBL 6.929999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein bL12m (SINGLE PROTEIN), Homo sapiens
UniProt: P52815
Assay: Binding affinity to human MRPL12 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 116.57 nM (pChEMBL 6.929999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein bL19m (SINGLE PROTEIN), Homo sapiens
UniProt: P49406
Assay: Binding affinity to human MRPL19 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 390.77 nM (pChEMBL 6.409999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein bL19m (SINGLE PROTEIN), Homo sapiens
UniProt: P49406
Assay: Binding affinity to human MRPL19 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 390.77 nM (pChEMBL 6.409999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein mL37 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BZE1
Assay: Binding affinity to human MRPL37 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 20.3 nM (pChEMBL 7.690000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein mL37 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BZE1
Assay: Binding affinity to human MRPL37 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 20.3 nM (pChEMBL 7.690000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein mL38 (SINGLE PROTEIN), Homo sapiens
UniProt: Q96DV4
Assay: Binding affinity to human MRPL38 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 12.32 nM (pChEMBL 7.909999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein mL38 (SINGLE PROTEIN), Homo sapiens
UniProt: Q96DV4
Assay: Binding affinity to human MRPL38 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 12.32 nM (pChEMBL 7.909999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS17m (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y2R5
Assay: Binding affinity to human MRPS17 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 28.48 nM (pChEMBL 7.539999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS17m (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y2R5
Assay: Binding affinity to human MRPS17 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 30.46 nM (pChEMBL 7.519999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein mL66 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NVS2
Assay: Binding affinity to human MRPS18A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 57.67 nM (pChEMBL 7.239999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Large ribosomal subunit protein mL66 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NVS2
Assay: Binding affinity to human MRPS18A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 57.67 nM (pChEMBL 7.239999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein mS22 (SINGLE PROTEIN), Homo sapiens
UniProt: P82650
Assay: Binding affinity to human MRPS22 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1.029 nM (pChEMBL 8.989999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein mS22 (SINGLE PROTEIN), Homo sapiens
UniProt: P82650
Assay: Binding affinity to human MRPS22 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1.029 nM (pChEMBL 8.989999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein mS23 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y3D9
Assay: Binding affinity to human MRPS23 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 11429.78 nM (pChEMBL 4.940000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein mS23 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y3D9
Assay: Binding affinity to human MRPS23 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 11429.78 nM (pChEMBL 4.940000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS3m (SINGLE PROTEIN), Homo sapiens
UniProt: Q96EL2
Assay: Binding affinity to human MRPS24 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 728.67 nM (pChEMBL 6.139999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS3m (SINGLE PROTEIN), Homo sapiens
UniProt: Q96EL2
Assay: Binding affinity to human MRPS24 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 811.72 nM (pChEMBL 6.090000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein mS27 (SINGLE PROTEIN), Homo sapiens
UniProt: Q92552
Assay: Binding affinity to human MRPS27 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 835.13 nM (pChEMBL 6.079999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein mS27 (SINGLE PROTEIN), Homo sapiens
UniProt: Q92552
Assay: Binding affinity to human MRPS27 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 835.13 nM (pChEMBL 6.079999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein mS35 (SINGLE PROTEIN), Homo sapiens
UniProt: P82673
Assay: Binding affinity to human MRPS35 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 7.233 nM (pChEMBL 8.140000343322754)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein mS35 (SINGLE PROTEIN), Homo sapiens
UniProt: P82673
Assay: Binding affinity to human MRPS35 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 7.233 nM (pChEMBL 8.140000343322754)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS7m (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y2R9
Assay: Binding affinity to human MRPS7 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 154120.08 nM (pChEMBL 3.809999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS9m (SINGLE PROTEIN), Homo sapiens
UniProt: P82933
Assay: Binding affinity to human MRPS9 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 4629.72 nM (pChEMBL 5.329999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Small ribosomal subunit protein uS9m (SINGLE PROTEIN), Homo sapiens
UniProt: P82933
Assay: Binding affinity to human MRPS9 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 4629.72 nM (pChEMBL 5.329999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: mRNA turnover protein 4 homolog (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UKD2
Assay: Binding affinity to human MRTO4 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 311.1 nM (pChEMBL 6.510000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: mRNA turnover protein 4 homolog (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UKD2
Assay: Binding affinity to human MRTO4 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 311.1 nM (pChEMBL 6.510000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: DNA mismatch repair protein Msh2 (SINGLE PROTEIN), Homo sapiens
UniProt: P43246
Assay: Binding affinity to human MSH2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 52.92 nM (pChEMBL 7.28000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: DNA mismatch repair protein Msh2 (SINGLE PROTEIN), Homo sapiens
UniProt: P43246
Assay: Binding affinity to human MSH2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 52.92 nM (pChEMBL 7.28000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: DNA mismatch repair protein Msh6 (SINGLE PROTEIN), Homo sapiens
UniProt: P52701
Assay: Binding affinity to human MSH6 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 49.46 nM (pChEMBL 7.309999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: DNA mismatch repair protein Msh6 (SINGLE PROTEIN), Homo sapiens
UniProt: P52701
Assay: Binding affinity to human MSH6 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 49.46 nM (pChEMBL 7.309999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Methylsterol monooxygenase 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q15800
Assay: Binding affinity to human MSMO1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 384.36 nM (pChEMBL 6.420000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Methylsterol monooxygenase 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q15800
Assay: Binding affinity to human MSMO1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 498.31 nM (pChEMBL 6.300000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Moesin (SINGLE PROTEIN), Homo sapiens
UniProt: P26038
Assay: Binding affinity to human MSN incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 256.45 nM (pChEMBL 6.590000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Moesin (SINGLE PROTEIN), Homo sapiens
UniProt: P26038
Assay: Binding affinity to human MSN incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 256.45 nM (pChEMBL 6.590000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: ATP synthase F(0) complex subunit a (SINGLE PROTEIN), Homo sapiens
UniProt: P00846
Assay: Binding affinity to human MT-ATP6 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 622.15 nM (pChEMBL 6.210000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: ATP synthase F(0) complex subunit a (SINGLE PROTEIN), Homo sapiens
UniProt: P00846
Assay: Binding affinity to human MT-ATP6 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 622.15 nM (pChEMBL 6.210000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Mitochondrial carrier homolog 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y6C9
Assay: Binding affinity to human MTCH2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 130.49 nM (pChEMBL 6.880000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Mitochondrial carrier homolog 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y6C9
Assay: Binding affinity to human MTCH2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 130.49 nM (pChEMBL 6.880000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Cytochrome c oxidase subunit 2 (SINGLE PROTEIN), Homo sapiens
UniProt: P00403
Assay: Binding affinity to human MT-CO2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 153.48 nM (pChEMBL 6.809999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Cytochrome c oxidase subunit 2 (SINGLE PROTEIN), Homo sapiens
UniProt: P00403
Assay: Binding affinity to human MT-CO2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 153.48 nM (pChEMBL 6.809999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Cytochrome c oxidase subunit 3 (SINGLE PROTEIN), Homo sapiens
UniProt: P00414
Assay: Binding affinity to human MT-CO3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2660.67 nM (pChEMBL 5.579999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Cytochrome c oxidase subunit 3 (SINGLE PROTEIN), Homo sapiens
UniProt: P00414
Assay: Binding affinity to human MT-CO3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2660.67 nM (pChEMBL 5.579999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein LYRIC (SINGLE PROTEIN), Homo sapiens
UniProt: Q86UE4
Assay: Binding affinity to human MTDH incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 6820.48 nM (pChEMBL 5.170000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein LYRIC (SINGLE PROTEIN), Homo sapiens
UniProt: Q86UE4
Assay: Binding affinity to human MTDH incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 6820.48 nM (pChEMBL 5.170000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: C-1-tetrahydrofolate synthase, cytoplasmic (SINGLE PROTEIN), Homo sapiens
UniProt: P11586
Assay: Binding affinity to human MTHFD1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 87.14 nM (pChEMBL 7.059999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: C-1-tetrahydrofolate synthase, cytoplasmic (SINGLE PROTEIN), Homo sapiens
UniProt: P11586
Assay: Binding affinity to human MTHFD1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 87.14 nM (pChEMBL 7.059999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: NADH-ubiquinone oxidoreductase chain 1 (SINGLE PROTEIN), Homo sapiens
UniProt: P03886
Assay: Binding affinity to human MT-ND1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 306.26 nM (pChEMBL 6.510000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: NADH-ubiquinone oxidoreductase chain 1 (SINGLE PROTEIN), Homo sapiens
UniProt: P03886
Assay: Binding affinity to human MT-ND1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 306.26 nM (pChEMBL 6.510000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: NADH-ubiquinone oxidoreductase chain 4 (SINGLE PROTEIN), Homo sapiens
UniProt: P03905
Assay: Binding affinity to human MT-ND4 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 648.98 nM (pChEMBL 6.190000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: NADH-ubiquinone oxidoreductase chain 4 (SINGLE PROTEIN), Homo sapiens
UniProt: P03905
Assay: Binding affinity to human MT-ND4 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 648.98 nM (pChEMBL 6.190000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase mTOR (SINGLE PROTEIN), Homo sapiens
UniProt: P42345
Assay: Binding affinity to human MTOR incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 443.38 nM (pChEMBL 6.349999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase mTOR (SINGLE PROTEIN), Homo sapiens
UniProt: P42345
Assay: Binding affinity to human MTOR incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 443.38 nM (pChEMBL 6.349999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Myotrophin (SINGLE PROTEIN), Homo sapiens
UniProt: P58546
Assay: Binding affinity to human MTPN incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 54313.83 nM (pChEMBL 4.260000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Myotrophin (SINGLE PROTEIN), Homo sapiens
UniProt: P58546
Assay: Binding affinity to human MTPN incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 54313.83 nM (pChEMBL 4.260000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Metaxin-1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q13505
Assay: Binding affinity to human MTX1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 118.42 nM (pChEMBL 6.929999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Metaxin-1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q13505
Assay: Binding affinity to human MTX1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 118.42 nM (pChEMBL 6.929999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Metaxin-2 (SINGLE PROTEIN), Homo sapiens
UniProt: O75431
Assay: Binding affinity to human MTX2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1771.8 nM (pChEMBL 5.75)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Metaxin-2 (SINGLE PROTEIN), Homo sapiens
UniProt: O75431
Assay: Binding affinity to human MTX2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1771.8 nM (pChEMBL 5.75)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Myeloid-associated differentiation marker (SINGLE PROTEIN), Homo sapiens
UniProt: Q96S97
Assay: Binding affinity to human MYADM incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 9168.65 nM (pChEMBL 5.039999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Myeloid-associated differentiation marker (SINGLE PROTEIN), Homo sapiens
UniProt: Q96S97
Assay: Binding affinity to human MYADM incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 9168.65 nM (pChEMBL 5.039999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Myb-binding protein 1A (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BQG0
Assay: Binding affinity to human MYBBP1A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1972.25 nM (pChEMBL 5.710000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Myb-binding protein 1A (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BQG0
Assay: Binding affinity to human MYBBP1A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1972.25 nM (pChEMBL 5.710000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: E3 ubiquitin-protein ligase MYCBP2 (SINGLE PROTEIN), Homo sapiens
UniProt: O75592
Assay: Binding affinity to human MYCBP2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 6.181 nM (pChEMBL 8.210000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: E3 ubiquitin-protein ligase MYCBP2 (SINGLE PROTEIN), Homo sapiens
UniProt: O75592
Assay: Binding affinity to human MYCBP2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 6.181 nM (pChEMBL 8.210000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Myosin-10 (SINGLE PROTEIN), Homo sapiens
UniProt: P35580
Assay: Binding affinity to human MYH10 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 3165993.29 nM (pChEMBL 2.5)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Myosin-9 (SINGLE PROTEIN), Homo sapiens
UniProt: P35579
Assay: Binding affinity to human MYH9 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 97.28 nM (pChEMBL 7.010000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Myosin-9 (SINGLE PROTEIN), Homo sapiens
UniProt: P35579
Assay: Binding affinity to human MYH9 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 97.28 nM (pChEMBL 7.010000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Myosin light chain 4 (SINGLE PROTEIN), Homo sapiens
UniProt: P12829
Assay: Binding affinity to human MYL4 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 36.39 nM (pChEMBL 7.440000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Myosin light chain 4 (SINGLE PROTEIN), Homo sapiens
UniProt: P12829
Assay: Binding affinity to human MYL4 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 118.41 nM (pChEMBL 6.929999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Myosin light polypeptide 6 (SINGLE PROTEIN), Homo sapiens
UniProt: P60660
Assay: Binding affinity to human MYL6 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 81.48 nM (pChEMBL 7.090000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Myosin light polypeptide 6 (SINGLE PROTEIN), Homo sapiens
UniProt: P60660
Assay: Binding affinity to human MYL6 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 81.48 nM (pChEMBL 7.090000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Myosin light chain kinase, smooth muscle (SINGLE PROTEIN), Homo sapiens
UniProt: Q15746
Assay: Binding affinity to human MYLK incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 0.317 nM (pChEMBL 9.5)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Myosin light chain kinase, smooth muscle (SINGLE PROTEIN), Homo sapiens
UniProt: Q15746
Assay: Binding affinity to human MYLK incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 0.38 nM (pChEMBL 9.420000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Myosin light chain kinase (SINGLE PROTEIN), Homo sapiens
UniProt: Q32MK0
Assay: Binding affinity to human MYLK3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 284.92 nM (pChEMBL 6.539999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Myosin light chain kinase (SINGLE PROTEIN), Homo sapiens
UniProt: Q32MK0
Assay: Binding affinity to human MYLK3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 327.38 nM (pChEMBL 6.489999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Unconventional myosin-Ib (SINGLE PROTEIN), Homo sapiens
UniProt: O43795
Assay: Binding affinity to human MYO1B incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 6768.81 nM (pChEMBL 5.170000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Unconventional myosin-Ib (SINGLE PROTEIN), Homo sapiens
UniProt: O43795
Assay: Binding affinity to human MYO1B incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 7178.55 nM (pChEMBL 5.139999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Unconventional myosin-If (SINGLE PROTEIN), Homo sapiens
UniProt: O00160
Assay: Binding affinity to human MYO1F incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 105.27 nM (pChEMBL 6.980000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Unconventional myosin-If (SINGLE PROTEIN), Homo sapiens
UniProt: O00160
Assay: Binding affinity to human MYO1F incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 105.27 nM (pChEMBL 6.980000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: N-alpha-acetyltransferase 10 (SINGLE PROTEIN), Homo sapiens
UniProt: P41227
Assay: Binding affinity to human NAA10 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 817.27 nM (pChEMBL 6.090000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: N-alpha-acetyltransferase 10 (SINGLE PROTEIN), Homo sapiens
UniProt: P41227
Assay: Binding affinity to human NAA10 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 817.27 nM (pChEMBL 6.090000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: N-alpha-acetyltransferase 15, NatA auxiliary subunit (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BXJ9
Assay: Binding affinity to human NAA15 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2068.79 nM (pChEMBL 5.679999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: N-alpha-acetyltransferase 15, NatA auxiliary subunit (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BXJ9
Assay: Binding affinity to human NAA15 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2068.79 nM (pChEMBL 5.679999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: N-alpha-acetyltransferase 50 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9GZZ1
Assay: Binding affinity to human NAA50 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1748.91 nM (pChEMBL 5.760000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: N-alpha-acetyltransferase 50 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9GZZ1
Assay: Binding affinity to human NAA50 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1748.91 nM (pChEMBL 5.760000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Nicotinamide phosphoribosyltransferase (SINGLE PROTEIN), Homo sapiens
UniProt: P43490
Assay: Binding affinity to human NAMPT incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 5.473 nM (pChEMBL 8.260000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Nicotinamide phosphoribosyltransferase (SINGLE PROTEIN), Homo sapiens
UniProt: P43490
Assay: Binding affinity to human NAMPT incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 5.473 nM (pChEMBL 8.260000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: N-acetylneuraminate-9-phosphate synthase (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NR45
Assay: Binding affinity to human NANS incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 89.95 nM (pChEMBL 7.050000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: N-acetylneuraminate-9-phosphate synthase (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NR45
Assay: Binding affinity to human NANS incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 89.95 nM (pChEMBL 7.050000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Nucleosome assembly protein 1-like 1 (SINGLE PROTEIN), Homo sapiens
UniProt: P55209
Assay: Binding affinity to human NAP1L1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 147186.39 nM (pChEMBL 3.8299999237060547)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Alpha-soluble NSF attachment protein (SINGLE PROTEIN), Homo sapiens
UniProt: P54920
Assay: Binding affinity to human NAPA incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 431250.72 nM (pChEMBL 3.369999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Nicotinate phosphoribosyltransferase (SINGLE PROTEIN), Homo sapiens
UniProt: Q6XQN6
Assay: Binding affinity to human NAPRT incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 0.495 nM (pChEMBL 9.300000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Nicotinate phosphoribosyltransferase (SINGLE PROTEIN), Homo sapiens
UniProt: Q6XQN6
Assay: Binding affinity to human NAPRT incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 0.495 nM (pChEMBL 9.300000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Asparagine--tRNA ligase, cytoplasmic (SINGLE PROTEIN), Homo sapiens
UniProt: O43776
Assay: Binding affinity to human NARS incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 5573.5 nM (pChEMBL 5.25)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Asparagine--tRNA ligase, cytoplasmic (SINGLE PROTEIN), Homo sapiens
UniProt: O43776
Assay: Binding affinity to human NARS incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 5573.5 nM (pChEMBL 5.25)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Nuclear autoantigenic sperm protein (SINGLE PROTEIN), Homo sapiens
UniProt: P49321
Assay: Binding affinity to human NASP incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 81.49 nM (pChEMBL 7.090000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Nuclear autoantigenic sperm protein (SINGLE PROTEIN), Homo sapiens
UniProt: P49321
Assay: Binding affinity to human NASP incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 81.49 nM (pChEMBL 7.090000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: RNA cytidine acetyltransferase (SINGLE PROTEIN), Homo sapiens
UniProt: Q9H0A0
Assay: Binding affinity to human NAT10 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 235.18 nM (pChEMBL 6.630000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: RNA cytidine acetyltransferase (SINGLE PROTEIN), Homo sapiens
UniProt: Q9H0A0
Assay: Binding affinity to human NAT10 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 235.18 nM (pChEMBL 6.630000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: NBAS subunit of NRZ tethering complex (SINGLE PROTEIN), Homo sapiens
UniProt: A2RRP1
Assay: Binding affinity to human NBAS incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 21826.36 nM (pChEMBL 4.659999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: NBAS subunit of NRZ tethering complex (SINGLE PROTEIN), Homo sapiens
UniProt: A2RRP1
Assay: Binding affinity to human NBAS incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 22375.89 nM (pChEMBL 4.650000095367432)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Condensin complex subunit 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q15021
Assay: Binding affinity to human NCAPD2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 28.75 nM (pChEMBL 7.539999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32