lovingscience/chembl-v37-raw-activities huggingface dataset:
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: NSFL1 cofactor p47 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UNZ2
Assay: Binding affinity to human NSFL1C incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 84.98 nM (pChEMBL 7.070000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: NSFL1 cofactor p47 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UNZ2
Assay: Binding affinity to human NSFL1C incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 84.98 nM (pChEMBL 7.070000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: RNA cytosine C(5)-methyltransferase NSUN2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q08J23
Assay: Binding affinity to human NSUN2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 0.187 nM (pChEMBL 9.729999542236328)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: RNA cytosine C(5)-methyltransferase NSUN2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q08J23
Assay: Binding affinity to human NSUN2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 0.187 nM (pChEMBL 9.729999542236328)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 5'-nucleotidase domain-containing protein 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9H857
Assay: Binding affinity to human NT5DC2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1723.58 nM (pChEMBL 5.760000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 5'-nucleotidase domain-containing protein 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9H857
Assay: Binding affinity to human NT5DC2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1723.58 nM (pChEMBL 5.760000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Cancer-related nucleoside-triphosphatase (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BSD7
Assay: Binding affinity to human NTPCR incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 57.43 nM (pChEMBL 7.239999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Cancer-related nucleoside-triphosphatase (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BSD7
Assay: Binding affinity to human NTPCR incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 60.81 nM (pChEMBL 7.21999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: High affinity nerve growth factor receptor (SINGLE PROTEIN), Homo sapiens
UniProt: P04629
Assay: Binding affinity to human NTRK1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 545.95 nM (pChEMBL 6.260000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: High affinity nerve growth factor receptor (SINGLE PROTEIN), Homo sapiens
UniProt: P04629
Assay: Binding affinity to human NTRK1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 773.45 nM (pChEMBL 6.110000133514404)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Nucleobindin-2 (SINGLE PROTEIN), Homo sapiens
UniProt: P80303
Assay: Binding affinity to human NUCB2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 79369.13 nM (pChEMBL 4.099999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Nucleobindin-2 (SINGLE PROTEIN), Homo sapiens
UniProt: P80303
Assay: Binding affinity to human NUCB2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 79369.13 nM (pChEMBL 4.099999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Nuclear migration protein nudC (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y266
Assay: Binding affinity to human NUDC incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 511.4 nM (pChEMBL 6.289999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Nuclear migration protein nudC (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y266
Assay: Binding affinity to human NUDC incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 511.4 nM (pChEMBL 6.289999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Cleavage and polyadenylation specificity factor subunit 5 (SINGLE PROTEIN), Homo sapiens
UniProt: O43809
Assay: Binding affinity to human NUDT21 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1464.67 nM (pChEMBL 5.829999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Cleavage and polyadenylation specificity factor subunit 5 (SINGLE PROTEIN), Homo sapiens
UniProt: O43809
Assay: Binding affinity to human NUDT21 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1464.67 nM (pChEMBL 5.829999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: ADP-sugar pyrophosphatase (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UKK9
Assay: Binding affinity to human NUDT5 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 7684.47 nM (pChEMBL 5.110000133514404)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: ADP-sugar pyrophosphatase (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UKK9
Assay: Binding affinity to human NUDT5 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 7982.6 nM (pChEMBL 5.099999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Nuclear mitotic apparatus protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q14980
Assay: Binding affinity to human NUMA1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 31.84 nM (pChEMBL 7.5)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Nuclear mitotic apparatus protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q14980
Assay: Binding affinity to human NUMA1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 31.84 nM (pChEMBL 7.5)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Nuclear pore complex protein Nup155 (SINGLE PROTEIN), Homo sapiens
UniProt: O75694
Assay: Binding affinity to human NUP155 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 193.41 nM (pChEMBL 6.710000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Nuclear pore complex protein Nup155 (SINGLE PROTEIN), Homo sapiens
UniProt: O75694
Assay: Binding affinity to human NUP155 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 193.41 nM (pChEMBL 6.710000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Nuclear pore complex protein Nup160 (SINGLE PROTEIN), Homo sapiens
UniProt: Q12769
Assay: Binding affinity to human NUP160 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 160433.93 nM (pChEMBL 3.7899999618530273)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Nucleoporin NUP188 (SINGLE PROTEIN), Homo sapiens
UniProt: Q5SRE5
Assay: Binding affinity to human NUP188 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 218.78 nM (pChEMBL 6.659999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Nucleoporin NUP188 (SINGLE PROTEIN), Homo sapiens
UniProt: Q5SRE5
Assay: Binding affinity to human NUP188 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 218.78 nM (pChEMBL 6.659999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Nuclear pore complex protein Nup205 (SINGLE PROTEIN), Homo sapiens
UniProt: Q92621
Assay: Binding affinity to human NUP205 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1173.52 nM (pChEMBL 5.929999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Nuclear pore complex protein Nup205 (SINGLE PROTEIN), Homo sapiens
UniProt: Q92621
Assay: Binding affinity to human NUP205 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1173.52 nM (pChEMBL 5.929999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Nuclear pore membrane glycoprotein 210 (SINGLE PROTEIN), Homo sapiens
UniProt: Q8TEM1
Assay: Binding affinity to human NUP210 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 5915.42 nM (pChEMBL 5.230000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Nuclear pore membrane glycoprotein 210 (SINGLE PROTEIN), Homo sapiens
UniProt: Q8TEM1
Assay: Binding affinity to human NUP210 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 5915.42 nM (pChEMBL 5.230000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Nuclear pore complex protein Nup50 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UKX7
Assay: Binding affinity to human NUP50 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 50.59 nM (pChEMBL 7.300000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Nuclear pore complex protein Nup50 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UKX7
Assay: Binding affinity to human NUP50 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 50.59 nM (pChEMBL 7.300000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Nuclear pore complex protein Nup93 (SINGLE PROTEIN), Homo sapiens
UniProt: Q8N1F7
Assay: Binding affinity to human NUP93 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1554.37 nM (pChEMBL 5.809999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Nuclear pore complex protein Nup93 (SINGLE PROTEIN), Homo sapiens
UniProt: Q8N1F7
Assay: Binding affinity to human NUP93 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1554.37 nM (pChEMBL 5.809999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Nuclear transport factor 2 (SINGLE PROTEIN), Homo sapiens
UniProt: P61970
Assay: Binding affinity to human NUTF2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 419.21 nM (pChEMBL 6.380000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Nuclear transport factor 2 (SINGLE PROTEIN), Homo sapiens
UniProt: P61970
Assay: Binding affinity to human NUTF2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 419.21 nM (pChEMBL 6.380000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Nuclear RNA export factor 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UBU9
Assay: Binding affinity to human NXF1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 18.33 nM (pChEMBL 7.739999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Nuclear RNA export factor 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UBU9
Assay: Binding affinity to human NXF1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 19.74 nM (pChEMBL 7.710000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: OCIA domain-containing protein 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q56VL3
Assay: Binding affinity to human OCIAD2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 3241.62 nM (pChEMBL 5.489999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: OCIA domain-containing protein 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q56VL3
Assay: Binding affinity to human OCIAD2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 3241.62 nM (pChEMBL 5.489999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 2-oxoglutarate dehydrogenase complex component E1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q02218
Assay: Binding affinity to human OGDH incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 12494.53 nM (pChEMBL 4.900000095367432)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 2-oxoglutarate dehydrogenase complex component E1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q02218
Assay: Binding affinity to human OGDH incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 12494.53 nM (pChEMBL 4.900000095367432)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Opioid growth factor receptor (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NZT2
Assay: Binding affinity to human OGFR incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 195.61 nM (pChEMBL 6.710000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Opioid growth factor receptor (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NZT2
Assay: Binding affinity to human OGFR incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 195.61 nM (pChEMBL 6.710000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Obg-like ATPase 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NTK5
Assay: Binding affinity to human OLA1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2135922.36 nM (pChEMBL 2.6700000762939453)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Dynamin-like GTPase OPA1, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: O60313
Assay: Binding affinity to human OPA1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 72.92 nM (pChEMBL 7.139999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Dynamin-like GTPase OPA1, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: O60313
Assay: Binding affinity to human OPA1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 72.92 nM (pChEMBL 7.139999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Olfactory receptor 10J3 (SINGLE PROTEIN), Homo sapiens
UniProt: Q5JRS4
Assay: Binding affinity to human OR10J3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1725.29 nM (pChEMBL 5.760000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Olfactory receptor 10J3 (SINGLE PROTEIN), Homo sapiens
UniProt: Q5JRS4
Assay: Binding affinity to human OR10J3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1725.29 nM (pChEMBL 5.760000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: ORM1-like protein 3 (SINGLE PROTEIN), Homo sapiens
UniProt: Q8N138
Assay: Binding affinity to human ORMDL3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 7465.15 nM (pChEMBL 5.130000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: ORM1-like protein 3 (SINGLE PROTEIN), Homo sapiens
UniProt: Q8N138
Assay: Binding affinity to human ORMDL3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 7465.15 nM (pChEMBL 5.130000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Oxysterol-binding protein-related protein 8 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BZF1
Assay: Binding affinity to human OSBPL8 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 650429.16 nM (pChEMBL 3.190000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: tRNA N6-adenosine threonylcarbamoyltransferase (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NPF4
Assay: Binding affinity to human OSGEP incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 8134.26 nM (pChEMBL 5.090000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: tRNA N6-adenosine threonylcarbamoyltransferase (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NPF4
Assay: Binding affinity to human OSGEP incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 8474.93 nM (pChEMBL 5.070000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Oligosaccharyltransferase complex subunit OSTC (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NRP0
Assay: Binding affinity to human OSTC incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1152.42 nM (pChEMBL 5.940000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Oligosaccharyltransferase complex subunit OSTC (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NRP0
Assay: Binding affinity to human OSTC incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1152.42 nM (pChEMBL 5.940000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Ubiquitin thioesterase OTUB1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q96FW1
Assay: Binding affinity to human OTUB1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 654.68 nM (pChEMBL 6.179999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Ubiquitin thioesterase OTUB1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q96FW1
Assay: Binding affinity to human OTUB1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 654.68 nM (pChEMBL 6.179999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Mitochondrial inner membrane protein OXA1L (SINGLE PROTEIN), Homo sapiens
UniProt: Q15070
Assay: Binding affinity to human OXA1L incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 6499.74 nM (pChEMBL 5.190000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Mitochondrial inner membrane protein OXA1L (SINGLE PROTEIN), Homo sapiens
UniProt: Q15070
Assay: Binding affinity to human OXA1L incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 6499.74 nM (pChEMBL 5.190000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Prolyl 4-hydroxylase subunit alpha-1 (SINGLE PROTEIN), Homo sapiens
UniProt: P13674
Assay: Binding affinity to human P4HA1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 0.132 nM (pChEMBL 9.880000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Prolyl 4-hydroxylase subunit alpha-1 (SINGLE PROTEIN), Homo sapiens
UniProt: P13674
Assay: Binding affinity to human P4HA1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 0.132 nM (pChEMBL 9.880000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein disulfide-isomerase (SINGLE PROTEIN), Homo sapiens
UniProt: P07237
Assay: Binding affinity to human P4HB incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 11697.92 nM (pChEMBL 4.929999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein disulfide-isomerase (SINGLE PROTEIN), Homo sapiens
UniProt: P07237
Assay: Binding affinity to human P4HB incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 11697.92 nM (pChEMBL 4.929999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proliferation-associated protein 2G4 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UQ80
Assay: Binding affinity to human PA2G4 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 364.58 nM (pChEMBL 6.440000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proliferation-associated protein 2G4 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UQ80
Assay: Binding affinity to human PA2G4 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 364.58 nM (pChEMBL 6.440000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Polyadenylate-binding protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: P11940
Assay: Binding affinity to human PABPC1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 10667.57 nM (pChEMBL 4.96999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Polyadenylate-binding protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: P11940
Assay: Binding affinity to human PABPC1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 10667.57 nM (pChEMBL 4.96999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Platelet-activating factor acetylhydrolase IB subunit alpha2 (SINGLE PROTEIN), Homo sapiens
UniProt: P68402
Assay: Binding affinity to human PAFAH1B2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 115185.62 nM (pChEMBL 3.940000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Platelet-activating factor acetylhydrolase IB subunit alpha1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q15102
Assay: Binding affinity to human PAFAH1B3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 13147.81 nM (pChEMBL 4.880000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Platelet-activating factor acetylhydrolase IB subunit alpha1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q15102
Assay: Binding affinity to human PAFAH1B3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 13147.81 nM (pChEMBL 4.880000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NWQ8
Assay: Binding affinity to human PAG1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 873.38 nM (pChEMBL 6.059999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Phosphoprotein associated with glycosphingolipid-enriched microdomains 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NWQ8
Assay: Binding affinity to human PAG1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1772.84 nM (pChEMBL 5.75)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (SINGLE PROTEIN), Homo sapiens
UniProt: P22234
Assay: Binding affinity to human PAICS incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 54.77 nM (pChEMBL 7.260000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Bifunctional phosphoribosylaminoimidazole carboxylase/phosphoribosylaminoimidazole succinocarboxamide synthetase (SINGLE PROTEIN), Homo sapiens
UniProt: P22234
Assay: Binding affinity to human PAICS incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 54.77 nM (pChEMBL 7.260000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Polyadenylate-binding protein-interacting protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9H074
Assay: Binding affinity to human PAIP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 3.242 nM (pChEMBL 8.489999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Polyadenylate-binding protein-interacting protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9H074
Assay: Binding affinity to human PAIP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 5.519 nM (pChEMBL 8.260000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase PAK 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q13177
Assay: Binding affinity to PAK2 human incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 42518.27 nM (pChEMBL 4.369999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase PAK 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q13177
Assay: Binding affinity to PAK2 human incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 42518.27 nM (pChEMBL 4.369999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase PAK 4 (SINGLE PROTEIN), Homo sapiens
UniProt: O96013
Assay: Binding affinity to PAK4 human incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 15096.33 nM (pChEMBL 4.820000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase PAK 4 (SINGLE PROTEIN), Homo sapiens
UniProt: O96013
Assay: Binding affinity to PAK4 human incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 25121.99 nM (pChEMBL 4.599999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase PAK 6 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NQU5
Assay: Binding affinity to PAK6 human incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 392.17 nM (pChEMBL 6.409999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase PAK 6 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NQU5
Assay: Binding affinity to PAK6 human incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 526.45 nM (pChEMBL 6.28000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (SINGLE PROTEIN), Homo sapiens
UniProt: O43252
Assay: Binding affinity to human PAPSS1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 30821.62 nM (pChEMBL 4.510000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Bifunctional 3'-phosphoadenosine 5'-phosphosulfate synthase 1 (SINGLE PROTEIN), Homo sapiens
UniProt: O43252
Assay: Binding affinity to human PAPSS1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 30821.62 nM (pChEMBL 4.510000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Parkinson disease protein 7 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99497
Assay: Binding affinity to human PARK7 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 54.81 nM (pChEMBL 7.260000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Parkinson disease protein 7 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99497
Assay: Binding affinity to human PARK7 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 54.81 nM (pChEMBL 7.260000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Poly [ADP-ribose] polymerase 1 (SINGLE PROTEIN), Homo sapiens
UniProt: P09874
Assay: Binding affinity to human PARP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 82.98 nM (pChEMBL 7.079999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Poly [ADP-ribose] polymerase 1 (SINGLE PROTEIN), Homo sapiens
UniProt: P09874
Assay: Binding affinity to human PARP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 82.98 nM (pChEMBL 7.079999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein mono-ADP-ribosyltransferase PARP16 (SINGLE PROTEIN), Homo sapiens
UniProt: Q8N5Y8
Assay: Binding affinity to human PARP16 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 22247972.94 nM (pChEMBL 1.649999976158142)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein PBDC1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BVG4
Assay: Binding affinity to human PBDC1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 48.58 nM (pChEMBL 7.309999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein PBDC1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BVG4
Assay: Binding affinity to human PBDC1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 72.95 nM (pChEMBL 7.139999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Lymphokine-activated killer T-cell-originated protein kinase (SINGLE PROTEIN), Homo sapiens
UniProt: Q96KB5
Assay: Binding affinity to human PBK incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 362.99 nM (pChEMBL 6.440000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Lymphokine-activated killer T-cell-originated protein kinase (SINGLE PROTEIN), Homo sapiens
UniProt: Q96KB5
Assay: Binding affinity to human PBK incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 362.99 nM (pChEMBL 6.440000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Poly(rC)-binding protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q15365
Assay: Binding affinity to human PCBP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 52.95 nM (pChEMBL 7.28000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Poly(rC)-binding protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q15365
Assay: Binding affinity to human PCBP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 52.95 nM (pChEMBL 7.28000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Propionyl-CoA carboxylase alpha chain, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: P05165
Assay: Binding affinity to human PCCA incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 6783.34 nM (pChEMBL 5.170000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Propionyl-CoA carboxylase alpha chain, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: P05165
Assay: Binding affinity to human PCCA incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 7069.6 nM (pChEMBL 5.150000095367432)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: PCI domain-containing protein 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q5JVF3
Assay: Binding affinity to human PCID2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1449096.58 nM (pChEMBL 2.8399999141693115)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: Q16822
Assay: Binding affinity to human PCK2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 428.93 nM (pChEMBL 6.369999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Phosphoenolpyruvate carboxykinase [GTP], mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: Q16822
Assay: Binding affinity to human PCK2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 428.93 nM (pChEMBL 6.369999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein-L-isoaspartate(D-aspartate) O-methyltransferase (SINGLE PROTEIN), Homo sapiens
UniProt: P22061
Assay: Binding affinity to human PCMT1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 392.7 nM (pChEMBL 6.409999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein-L-isoaspartate(D-aspartate) O-methyltransferase (SINGLE PROTEIN), Homo sapiens
UniProt: P22061
Assay: Binding affinity to human PCMT1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 392.7 nM (pChEMBL 6.409999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proliferating cell nuclear antigen (SINGLE PROTEIN), Homo sapiens
UniProt: P12004
Assay: Binding affinity to human PCNA incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 502.2 nM (pChEMBL 6.300000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proliferating cell nuclear antigen (SINGLE PROTEIN), Homo sapiens
UniProt: P12004
Assay: Binding affinity to human PCNA incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 502.2 nM (pChEMBL 6.300000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: PEST proteolytic signal-containing nuclear protein (SINGLE PROTEIN), Homo sapiens
UniProt: Q8WW12
Assay: Binding affinity to human PCNP incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 198.93 nM (pChEMBL 6.699999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: PEST proteolytic signal-containing nuclear protein (SINGLE PROTEIN), Homo sapiens
UniProt: Q8WW12
Assay: Binding affinity to human PCNP incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 198.93 nM (pChEMBL 6.699999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 28 kDa heat- and acid-stable phosphoprotein (SINGLE PROTEIN), Homo sapiens
UniProt: Q13442
Assay: Binding affinity to human PDAP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 67600.28 nM (pChEMBL 4.170000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 28 kDa heat- and acid-stable phosphoprotein (SINGLE PROTEIN), Homo sapiens
UniProt: Q13442
Assay: Binding affinity to human PDAP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 67600.28 nM (pChEMBL 4.170000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein RRP5 homolog (SINGLE PROTEIN), Homo sapiens
UniProt: Q14690
Assay: Binding affinity to human PDCD11 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 71.72 nM (pChEMBL 7.139999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein RRP5 homolog (SINGLE PROTEIN), Homo sapiens
UniProt: Q14690
Assay: Binding affinity to human PDCD11 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 71.72 nM (pChEMBL 7.139999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Programmed cell death protein 4 (SINGLE PROTEIN), Homo sapiens
UniProt: Q53EL6
Assay: Binding affinity to human PDCD4 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 126.88 nM (pChEMBL 6.900000095367432)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Programmed cell death protein 4 (SINGLE PROTEIN), Homo sapiens
UniProt: Q53EL6
Assay: Binding affinity to human PDCD4 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 126.88 nM (pChEMBL 6.900000095367432)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32