lovingscience/chembl-v37-raw-activities huggingface dataset:
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Threonine--tRNA ligase 1, cytoplasmic (SINGLE PROTEIN), Homo sapiens
UniProt: P26639
Assay: Binding affinity to human TARS incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 57.65 nM (pChEMBL 7.239999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Threonine--tRNA ligase 1, cytoplasmic (SINGLE PROTEIN), Homo sapiens
UniProt: P26639
Assay: Binding affinity to human TARS incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 57.65 nM (pChEMBL 7.239999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Threonine--tRNA ligase, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BW92
Assay: Binding affinity to human TARS2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 5.919 nM (pChEMBL 8.229999542236328)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Threonine--tRNA ligase, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BW92
Assay: Binding affinity to human TARS2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 5.919 nM (pChEMBL 8.229999542236328)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: TBC1 domain family member 15 (SINGLE PROTEIN), Homo sapiens
UniProt: Q8TC07
Assay: Binding affinity to human TBC1D15 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 26275.23 nM (pChEMBL 4.579999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: TBC1 domain family member 15 (SINGLE PROTEIN), Homo sapiens
UniProt: Q8TC07
Assay: Binding affinity to human TBC1D15 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 34886.5 nM (pChEMBL 4.460000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: TBC1 domain family member 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q92609
Assay: Binding affinity to human TBC1D5 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 26.48 nM (pChEMBL 7.579999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: TBC1 domain family member 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q92609
Assay: Binding affinity to human TBC1D5 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 26.48 nM (pChEMBL 7.579999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Tubulin-specific chaperone A (SINGLE PROTEIN), Homo sapiens
UniProt: O75347
Assay: Binding affinity to human TBCA incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 9.129 nM (pChEMBL 8.039999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Tubulin-specific chaperone A (SINGLE PROTEIN), Homo sapiens
UniProt: O75347
Assay: Binding affinity to human TBCA incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 9.129 nM (pChEMBL 8.039999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Tubulin-folding cofactor B (SINGLE PROTEIN), Homo sapiens
UniProt: Q99426
Assay: Binding affinity to human TBCB incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 3193.66 nM (pChEMBL 5.5)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Tubulin-folding cofactor B (SINGLE PROTEIN), Homo sapiens
UniProt: Q99426
Assay: Binding affinity to human TBCB incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 3328.2 nM (pChEMBL 5.480000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Tubulin-specific chaperone D (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BTW9
Assay: Binding affinity to human TBCD incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 5.417 nM (pChEMBL 8.270000457763672)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Tubulin-specific chaperone D (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BTW9
Assay: Binding affinity to human TBCD incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 5.417 nM (pChEMBL 8.270000457763672)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase TBK1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UHD2
Assay: Binding affinity to human TBK1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2459.45 nM (pChEMBL 5.610000133514404)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase TBK1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UHD2
Assay: Binding affinity to human TBK1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 3845.71 nM (pChEMBL 5.420000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: TANK-binding kinase 1-binding protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: A7MCY6
Assay: Binding affinity to human TBKBP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 47.61 nM (pChEMBL 7.320000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: TANK-binding kinase 1-binding protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: A7MCY6
Assay: Binding affinity to human TBKBP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 59.99 nM (pChEMBL 7.21999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: F-box-like/WD repeat-containing protein TBL1XR1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BZK7
Assay: Binding affinity to human TBL1XR1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 5.327 nM (pChEMBL 8.270000457763672)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: F-box-like/WD repeat-containing protein TBL1XR1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BZK7
Assay: Binding affinity to human TBL1XR1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 5.327 nM (pChEMBL 8.270000457763672)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Transducin beta-like protein 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y4P3
Assay: Binding affinity to human TBL2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 3695.38 nM (pChEMBL 5.429999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Transducin beta-like protein 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y4P3
Assay: Binding affinity to human TBL2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 3695.38 nM (pChEMBL 5.429999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: FAST kinase domain-containing protein 4 (SINGLE PROTEIN), Homo sapiens
UniProt: Q969Z0
Assay: Binding affinity to human TBRG4 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 97.07 nM (pChEMBL 7.010000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: FAST kinase domain-containing protein 4 (SINGLE PROTEIN), Homo sapiens
UniProt: Q969Z0
Assay: Binding affinity to human TBRG4 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 97.07 nM (pChEMBL 7.010000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Transcription elongation factor A protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: P23193
Assay: Binding affinity to human TCEA1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 25.13 nM (pChEMBL 7.599999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Transcription elongation factor A protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: P23193
Assay: Binding affinity to human TCEA1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 25.13 nM (pChEMBL 7.599999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Elongin-C (SINGLE PROTEIN), Homo sapiens
UniProt: Q15369
Assay: Binding affinity to human TCEB1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 681.6 nM (pChEMBL 6.170000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Elongin-C (SINGLE PROTEIN), Homo sapiens
UniProt: Q15369
Assay: Binding affinity to human TCEB1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 681.6 nM (pChEMBL 6.170000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Elongin-B (SINGLE PROTEIN), Homo sapiens
UniProt: Q15370
Assay: Binding affinity to human TCEB2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 25528.56 nM (pChEMBL 4.590000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Elongin-B (SINGLE PROTEIN), Homo sapiens
UniProt: Q15370
Assay: Binding affinity to human TCEB2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 25528.56 nM (pChEMBL 4.590000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Transcription elongation regulator 1 (SINGLE PROTEIN), Homo sapiens
UniProt: O14776
Assay: Binding affinity to human TCERG1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 53.22 nM (pChEMBL 7.269999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Transcription elongation regulator 1 (SINGLE PROTEIN), Homo sapiens
UniProt: O14776
Assay: Binding affinity to human TCERG1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 87.63 nM (pChEMBL 7.059999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Transcription factor 12 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99081
Assay: Binding affinity to human TCF12 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 74253.13 nM (pChEMBL 4.130000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Transcription factor 12 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99081
Assay: Binding affinity to human TCF12 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 74253.13 nM (pChEMBL 4.130000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Treacle protein (SINGLE PROTEIN), Homo sapiens
UniProt: Q13428
Assay: Binding affinity to human TCOF1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 4983.47 nM (pChEMBL 5.300000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Treacle protein (SINGLE PROTEIN), Homo sapiens
UniProt: Q13428
Assay: Binding affinity to human TCOF1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 4983.47 nM (pChEMBL 5.300000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: T-complex protein 1 subunit alpha (SINGLE PROTEIN), Homo sapiens
UniProt: P17987
Assay: Binding affinity to human TCP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 81.99 nM (pChEMBL 7.090000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: T-complex protein 1 subunit alpha (SINGLE PROTEIN), Homo sapiens
UniProt: P17987
Assay: Binding affinity to human TCP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 81.99 nM (pChEMBL 7.090000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Tyrosine-protein kinase Tec (SINGLE PROTEIN), Homo sapiens
UniProt: P42680
Assay: Binding affinity to human TEC incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 11.64 nM (pChEMBL 7.929999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Tyrosine-protein kinase Tec (SINGLE PROTEIN), Homo sapiens
UniProt: P42680
Assay: Binding affinity to human TEC incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 28.93 nM (pChEMBL 7.539999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Very-long-chain enoyl-CoA reductase (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NZ01
Assay: Binding affinity to human TECR incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1307.76 nM (pChEMBL 5.880000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Very-long-chain enoyl-CoA reductase (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NZ01
Assay: Binding affinity to human TECR incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1307.76 nM (pChEMBL 5.880000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Telomere length regulation protein TEL2 homolog (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y4R8
Assay: Binding affinity to human TELO2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 0.314 nM (pChEMBL 9.5)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Telomere length regulation protein TEL2 homolog (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y4R8
Assay: Binding affinity to human TELO2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 0.314 nM (pChEMBL 9.5)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Telomeric repeat-binding factor 2-interacting protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NYB0
Assay: Binding affinity to human TERF2IP incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 53.9 nM (pChEMBL 7.269999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Telomeric repeat-binding factor 2-interacting protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NYB0
Assay: Binding affinity to human TERF2IP incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 53.9 nM (pChEMBL 7.269999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Testin (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UGI8
Assay: Binding affinity to human TES incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 69436.04 nM (pChEMBL 4.159999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Testin (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UGI8
Assay: Binding affinity to human TES incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 76256.34 nM (pChEMBL 4.119999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Dual specificity testis-specific protein kinase 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q96S53
Assay: Binding affinity to human TESK2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 3.488 nM (pChEMBL 8.460000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Dual specificity testis-specific protein kinase 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q96S53
Assay: Binding affinity to human TESK2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 6.162 nM (pChEMBL 8.210000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Testis-expressed protein 13A (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BXU3
Assay: Binding affinity to human TEX13A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 786.24 nM (pChEMBL 6.099999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Testis-expressed protein 13A (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BXU3
Assay: Binding affinity to human TEX13A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 786.24 nM (pChEMBL 6.099999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Testis-expressed protein 264 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y6I9
Assay: Binding affinity to human TEX264 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 52.99 nM (pChEMBL 7.28000020980835)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Testis-expressed protein 264 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y6I9
Assay: Binding affinity to human TEX264 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 53.94 nM (pChEMBL 7.269999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Transcription factor A, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: Q00059
Assay: Binding affinity to human TFAM incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 48.7 nM (pChEMBL 7.309999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Transcription factor A, mitochondrial (SINGLE PROTEIN), Homo sapiens
UniProt: Q00059
Assay: Binding affinity to human TFAM incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 48.7 nM (pChEMBL 7.309999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Transferrin receptor protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: P02786
Assay: Binding affinity to human TFRC incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 7335.85 nM (pChEMBL 5.130000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Transferrin receptor protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: P02786
Assay: Binding affinity to human TFRC incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 7335.85 nM (pChEMBL 5.130000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: TGF-beta receptor type-1 (SINGLE PROTEIN), Homo sapiens
UniProt: P36897
Assay: Binding affinity to human TGFBR1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 20.13 nM (pChEMBL 7.699999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: TGF-beta receptor type-1 (SINGLE PROTEIN), Homo sapiens
UniProt: P36897
Assay: Binding affinity to human TGFBR1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 29.04 nM (pChEMBL 7.539999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: TGF-beta receptor type-2 (SINGLE PROTEIN), Homo sapiens
UniProt: P37173
Assay: Binding affinity to human TGFBR2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 6.662 nM (pChEMBL 8.180000305175781)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: TGF-beta receptor type-2 (SINGLE PROTEIN), Homo sapiens
UniProt: P37173
Assay: Binding affinity to human TGFBR2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 8.855 nM (pChEMBL 8.050000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Trans-Golgi network integral membrane protein 2 (SINGLE PROTEIN), Homo sapiens
UniProt: O43493
Assay: Binding affinity to human TGOLN2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 25460.73 nM (pChEMBL 4.590000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Trans-Golgi network integral membrane protein 2 (SINGLE PROTEIN), Homo sapiens
UniProt: O43493
Assay: Binding affinity to human TGOLN2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 25460.73 nM (pChEMBL 4.590000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein THEM6 (SINGLE PROTEIN), Homo sapiens
UniProt: Q8WUY1
Assay: Binding affinity to human THEM6 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 62.14 nM (pChEMBL 7.210000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein THEM6 (SINGLE PROTEIN), Homo sapiens
UniProt: Q8WUY1
Assay: Binding affinity to human THEM6 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 62.14 nM (pChEMBL 7.210000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: THO complex subunit 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q8NI27
Assay: Binding affinity to human THOC2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2049.7 nM (pChEMBL 5.690000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: THO complex subunit 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q8NI27
Assay: Binding affinity to human THOC2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2049.7 nM (pChEMBL 5.690000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Thimet oligopeptidase (SINGLE PROTEIN), Homo sapiens
UniProt: P52888
Assay: Binding affinity to human THOP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1993.17 nM (pChEMBL 5.699999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Thimet oligopeptidase (SINGLE PROTEIN), Homo sapiens
UniProt: P52888
Assay: Binding affinity to human THOP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1993.17 nM (pChEMBL 5.699999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Thyroid hormone receptor-associated protein 3 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y2W1
Assay: Binding affinity to human THRAP3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1270.58 nM (pChEMBL 5.900000095367432)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Thyroid hormone receptor-associated protein 3 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y2W1
Assay: Binding affinity to human THRAP3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1270.58 nM (pChEMBL 5.900000095367432)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: THUMP domain-containing protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NXG2
Assay: Binding affinity to human THUMPD1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 75000.23 nM (pChEMBL 4.119999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: THUMP domain-containing protein 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9NXG2
Assay: Binding affinity to human THUMPD1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 75000.23 nM (pChEMBL 4.119999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Cytotoxic granule associated RNA binding protein TIA1 (SINGLE PROTEIN), Homo sapiens
UniProt: P31483
Assay: Binding affinity to human TIA1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 483.24 nM (pChEMBL 6.320000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Cytotoxic granule associated RNA binding protein TIA1 (SINGLE PROTEIN), Homo sapiens
UniProt: P31483
Assay: Binding affinity to human TIA1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 572.43 nM (pChEMBL 6.239999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Nucleolysin TIAR (SINGLE PROTEIN), Homo sapiens
UniProt: Q01085
Assay: Binding affinity to human TIAL1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1.1 nM (pChEMBL 8.960000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Nucleolysin TIAR (SINGLE PROTEIN), Homo sapiens
UniProt: Q01085
Assay: Binding affinity to human TIAL1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1.286 nM (pChEMBL 8.890000343322754)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Mitochondrial import inner membrane translocase subunit Tim13 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y5L4
Assay: Binding affinity to human TIMM13 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 4230061.91 nM (pChEMBL 2.369999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Mitochondrial import inner membrane translocase subunit TIM44 (SINGLE PROTEIN), Homo sapiens
UniProt: O43615
Assay: Binding affinity to human TIMM44 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 309.91 nM (pChEMBL 6.510000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Mitochondrial import inner membrane translocase subunit TIM44 (SINGLE PROTEIN), Homo sapiens
UniProt: O43615
Assay: Binding affinity to human TIMM44 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 309.91 nM (pChEMBL 6.510000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Mitochondrial import inner membrane translocase subunit TIM50 (SINGLE PROTEIN), Homo sapiens
UniProt: Q3ZCQ8
Assay: Binding affinity to human TIMM50 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1849.55 nM (pChEMBL 5.730000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Mitochondrial import inner membrane translocase subunit TIM50 (SINGLE PROTEIN), Homo sapiens
UniProt: Q3ZCQ8
Assay: Binding affinity to human TIMM50 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1849.55 nM (pChEMBL 5.730000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Mitochondrial import inner membrane translocase subunit Tim9 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y5J7
Assay: Binding affinity to human TIMM9 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 10606.58 nM (pChEMBL 4.96999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Mitochondrial import inner membrane translocase subunit Tim9 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y5J7
Assay: Binding affinity to human TIMM9 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 11577.33 nM (pChEMBL 4.940000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: TIP41-like protein (SINGLE PROTEIN), Homo sapiens
UniProt: O75663
Assay: Binding affinity to human TIPRL incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 7005.47 nM (pChEMBL 5.159999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: TIP41-like protein (SINGLE PROTEIN), Homo sapiens
UniProt: O75663
Assay: Binding affinity to human TIPRL incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 10131.36 nM (pChEMBL 4.989999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Thymidine kinase, cytosolic (SINGLE PROTEIN), Homo sapiens
UniProt: P04183
Assay: Binding affinity to human TK1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 15.33 nM (pChEMBL 7.809999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Thymidine kinase, cytosolic (SINGLE PROTEIN), Homo sapiens
UniProt: P04183
Assay: Binding affinity to human TK1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 27.36 nM (pChEMBL 7.559999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Transketolase (SINGLE PROTEIN), Homo sapiens
UniProt: P29401
Assay: Binding affinity to human TKT incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 151.31 nM (pChEMBL 6.820000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Transketolase (SINGLE PROTEIN), Homo sapiens
UniProt: P29401
Assay: Binding affinity to human TKT incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 151.31 nM (pChEMBL 6.820000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Talin-1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y490
Assay: Binding affinity to human TLN1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 41.84 nM (pChEMBL 7.380000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Talin-1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y490
Assay: Binding affinity to human TLN1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 41.84 nM (pChEMBL 7.380000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Transmembrane 9 superfamily member 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99805
Assay: Binding affinity to human TM9SF2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 118.5 nM (pChEMBL 6.929999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Transmembrane 9 superfamily member 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99805
Assay: Binding affinity to human TM9SF2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 118.5 nM (pChEMBL 6.929999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Transmembrane 9 superfamily member 3 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9HD45
Assay: Binding affinity to human TM9SF3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 21.79 nM (pChEMBL 7.659999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Transmembrane 9 superfamily member 3 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9HD45
Assay: Binding affinity to human TM9SF3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 21.79 nM (pChEMBL 7.659999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Transmembrane 9 superfamily member 4 (SINGLE PROTEIN), Homo sapiens
UniProt: Q92544
Assay: Binding affinity to human TM9SF4 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 95322.67 nM (pChEMBL 4.019999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Transmembrane 9 superfamily member 4 (SINGLE PROTEIN), Homo sapiens
UniProt: Q92544
Assay: Binding affinity to human TM9SF4 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 95322.67 nM (pChEMBL 4.019999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Bax inhibitor 1 (SINGLE PROTEIN), Homo sapiens
UniProt: P55061
Assay: Binding affinity to human TMBIM6 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 30558.41 nM (pChEMBL 4.510000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Bax inhibitor 1 (SINGLE PROTEIN), Homo sapiens
UniProt: P55061
Assay: Binding affinity to human TMBIM6 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 30558.41 nM (pChEMBL 4.510000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Calcium load-activated calcium channel (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UM00
Assay: Binding affinity to human TMCO1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 280.86 nM (pChEMBL 6.550000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Calcium load-activated calcium channel (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UM00
Assay: Binding affinity to human TMCO1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 280.86 nM (pChEMBL 6.550000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Transmembrane emp24 domain-containing protein 10 (SINGLE PROTEIN), Homo sapiens
UniProt: P49755
Assay: Binding affinity to human TMED10 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 17885.63 nM (pChEMBL 4.75)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Transmembrane emp24 domain-containing protein 10 (SINGLE PROTEIN), Homo sapiens
UniProt: P49755
Assay: Binding affinity to human TMED10 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 17885.63 nM (pChEMBL 4.75)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Transmembrane emp24 domain-containing protein 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q15363
Assay: Binding affinity to human TMED2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 32472.19 nM (pChEMBL 4.489999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Transmembrane emp24 domain-containing protein 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q15363
Assay: Binding affinity to human TMED2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 32472.19 nM (pChEMBL 4.489999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Transmembrane emp24 domain-containing protein 7 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y3B3
Assay: Binding affinity to human TMED7 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2124.65 nM (pChEMBL 5.670000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Transmembrane emp24 domain-containing protein 7 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y3B3
Assay: Binding affinity to human TMED7 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2124.65 nM (pChEMBL 5.670000076293945)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Transmembrane emp24 domain-containing protein 9 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BVK6
Assay: Binding affinity to human TMED9 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 3.956 nM (pChEMBL 8.399999618530273)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Transmembrane emp24 domain-containing protein 9 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BVK6
Assay: Binding affinity to human TMED9 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 3.956 nM (pChEMBL 8.399999618530273)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Voltage-gated monoatomic cation channel TMEM109 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BVC6
Assay: Binding affinity to human TMEM109 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 5.418 nM (pChEMBL 8.270000457763672)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Voltage-gated monoatomic cation channel TMEM109 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BVC6
Assay: Binding affinity to human TMEM109 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 5.418 nM (pChEMBL 8.270000457763672)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32