lovingscience/chembl-v37-raw-activities huggingface dataset:
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 5'-AMP-activated protein kinase subunit gamma-2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UGJ0
Assay: Binding affinity to human PRKAG2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 26.31 nM (pChEMBL 7.579999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 5'-AMP-activated protein kinase subunit gamma-2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UGJ0
Assay: Binding affinity to human PRKAG2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 40.8 nM (pChEMBL 7.389999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: cAMP-dependent protein kinase type II-alpha regulatory subunit (SINGLE PROTEIN), Homo sapiens
UniProt: P13861
Assay: Binding affinity to human PRKAR2A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 324.66 nM (pChEMBL 6.489999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: cAMP-dependent protein kinase type II-alpha regulatory subunit (SINGLE PROTEIN), Homo sapiens
UniProt: P13861
Assay: Binding affinity to human PRKAR2A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 324.66 nM (pChEMBL 6.489999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein kinase C alpha type (SINGLE PROTEIN), Homo sapiens
UniProt: P17252
Assay: Binding affinity to human PRKCA incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1.466 nM (pChEMBL 8.829999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein kinase C alpha type (SINGLE PROTEIN), Homo sapiens
UniProt: P17252
Assay: Binding affinity to human PRKCA incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2.013 nM (pChEMBL 8.699999809265137)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein kinase C beta type (SINGLE PROTEIN), Homo sapiens
UniProt: P05771
Assay: Binding affinity to human PRKCB incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 698.26 nM (pChEMBL 6.159999847412109)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein kinase C beta type (SINGLE PROTEIN), Homo sapiens
UniProt: P05771
Assay: Binding affinity to human PRKCB incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 875.1 nM (pChEMBL 6.059999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein kinase C delta type (SINGLE PROTEIN), Homo sapiens
UniProt: Q05655
Assay: Binding affinity to human PRKCD incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 0.129 nM (pChEMBL 9.890000343322754)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein kinase C delta type (SINGLE PROTEIN), Homo sapiens
UniProt: Q05655
Assay: Binding affinity to human PRKCD incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 0.136 nM (pChEMBL 9.869999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein kinase C iota type (SINGLE PROTEIN), Homo sapiens
UniProt: P41743
Assay: Binding affinity to human PRKCI incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1353.55 nM (pChEMBL 5.869999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein kinase C iota type (SINGLE PROTEIN), Homo sapiens
UniProt: P41743
Assay: Binding affinity to human PRKCI incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1353.55 nM (pChEMBL 5.869999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein kinase C theta type (SINGLE PROTEIN), Homo sapiens
UniProt: Q04759
Assay: Binding affinity to human PRKCQ incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2631.64 nM (pChEMBL 5.579999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein kinase C theta type (SINGLE PROTEIN), Homo sapiens
UniProt: Q04759
Assay: Binding affinity to human PRKCQ incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2631.64 nM (pChEMBL 5.579999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Glucosidase 2 subunit beta (SINGLE PROTEIN), Homo sapiens
UniProt: P14314
Assay: Binding affinity to human PRKCSH incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 57.67 nM (pChEMBL 7.239999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Glucosidase 2 subunit beta (SINGLE PROTEIN), Homo sapiens
UniProt: P14314
Assay: Binding affinity to human PRKCSH incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 57.67 nM (pChEMBL 7.239999771118164)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase D2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BZL6
Assay: Binding affinity to human PRKD2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 30.86 nM (pChEMBL 7.510000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase D2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9BZL6
Assay: Binding affinity to human PRKD2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 46.82 nM (pChEMBL 7.329999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase D3 (SINGLE PROTEIN), Homo sapiens
UniProt: O94806
Assay: Binding affinity to human PRKD3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1149.16 nM (pChEMBL 5.940000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Serine/threonine-protein kinase D3 (SINGLE PROTEIN), Homo sapiens
UniProt: O94806
Assay: Binding affinity to human PRKD3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1552.45 nM (pChEMBL 5.809999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: cGMP-dependent protein kinase 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q13976
Assay: Binding affinity to human PRKG1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2502.13 nM (pChEMBL 5.599999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: cGMP-dependent protein kinase 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q13976
Assay: Binding affinity to human PRKG1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 4941.39 nM (pChEMBL 5.309999942779541)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein arginine N-methyltransferase 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99873
Assay: Binding affinity to human PRMT1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 36933.37 nM (pChEMBL 4.429999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein arginine N-methyltransferase 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99873
Assay: Binding affinity to human PRMT1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 36933.37 nM (pChEMBL 4.429999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein arginine N-methyltransferase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: O14744
Assay: Binding affinity to human PRMT5 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 3001.8 nM (pChEMBL 5.519999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein arginine N-methyltransferase 5 (SINGLE PROTEIN), Homo sapiens
UniProt: O14744
Assay: Binding affinity to human PRMT5 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 3001.8 nM (pChEMBL 5.519999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Pre-mRNA-processing factor 19 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UMS4
Assay: Binding affinity to human PRPF19 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 43431.28 nM (pChEMBL 4.360000133514404)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Pre-mRNA-processing factor 19 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UMS4
Assay: Binding affinity to human PRPF19 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 43431.28 nM (pChEMBL 4.360000133514404)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Pre-mRNA-processing factor 40 homolog A (SINGLE PROTEIN), Homo sapiens
UniProt: O75400
Assay: Binding affinity to human PRPF40A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 13.53 nM (pChEMBL 7.869999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Pre-mRNA-processing factor 40 homolog A (SINGLE PROTEIN), Homo sapiens
UniProt: O75400
Assay: Binding affinity to human PRPF40A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 13.53 nM (pChEMBL 7.869999885559082)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Pre-mRNA-processing factor 6 (SINGLE PROTEIN), Homo sapiens
UniProt: O94906
Assay: Binding affinity to human PRPF6 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2106.85 nM (pChEMBL 5.679999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Pre-mRNA-processing factor 6 (SINGLE PROTEIN), Homo sapiens
UniProt: O94906
Assay: Binding affinity to human PRPF6 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2106.85 nM (pChEMBL 5.679999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Pre-mRNA-processing-splicing factor 8 (SINGLE PROTEIN), Homo sapiens
UniProt: Q6P2Q9
Assay: Binding affinity to human PRPF8 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 552.75 nM (pChEMBL 6.260000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Pre-mRNA-processing-splicing factor 8 (SINGLE PROTEIN), Homo sapiens
UniProt: Q6P2Q9
Assay: Binding affinity to human PRPF8 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 552.75 nM (pChEMBL 6.260000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Peripherin (SINGLE PROTEIN), Homo sapiens
UniProt: P41219
Assay: Binding affinity to human PRPH incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 399.64 nM (pChEMBL 6.400000095367432)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Peripherin (SINGLE PROTEIN), Homo sapiens
UniProt: P41219
Assay: Binding affinity to human PRPH incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1739.15 nM (pChEMBL 5.760000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein PRRC2A (SINGLE PROTEIN), Homo sapiens
UniProt: P48634
Assay: Binding affinity to human PRRC2A incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 63.95 nM (pChEMBL 7.190000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein PRRC2A (SINGLE PROTEIN), Homo sapiens
UniProt: P48634
Assay: Binding affinity to human PRRC2A incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 63.95 nM (pChEMBL 7.190000057220459)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein PRRC2C (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y520
Assay: Binding affinity to human PRRC2C incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2515.15 nM (pChEMBL 5.599999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Protein PRRC2C (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y520
Assay: Binding affinity to human PRRC2C incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2515.15 nM (pChEMBL 5.599999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Phosphoserine aminotransferase (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y617
Assay: Binding affinity to human PSAT1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 263.96 nM (pChEMBL 6.579999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Phosphoserine aminotransferase (SINGLE PROTEIN), Homo sapiens
UniProt: Q9Y617
Assay: Binding affinity to human PSAT1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 263.96 nM (pChEMBL 6.579999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: PC4 and SFRS1-interacting protein (SINGLE PROTEIN), Homo sapiens
UniProt: O75475
Assay: Binding affinity to human PSIP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 59529.74 nM (pChEMBL 4.21999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: PC4 and SFRS1-interacting protein (SINGLE PROTEIN), Homo sapiens
UniProt: O75475
Assay: Binding affinity to human PSIP1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 59529.74 nM (pChEMBL 4.21999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome subunit alpha type-1 (SINGLE PROTEIN), Homo sapiens
UniProt: P25786
Assay: Binding affinity to human PSMA1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 9782.82 nM (pChEMBL 5.010000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome subunit alpha type-1 (SINGLE PROTEIN), Homo sapiens
UniProt: P25786
Assay: Binding affinity to human PSMA1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 9782.82 nM (pChEMBL 5.010000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome subunit alpha type-2 (SINGLE PROTEIN), Homo sapiens
UniProt: P25787
Assay: Binding affinity to human PSMA2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 15.88 nM (pChEMBL 7.800000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome subunit alpha type-2 (SINGLE PROTEIN), Homo sapiens
UniProt: P25787
Assay: Binding affinity to human PSMA2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 15.88 nM (pChEMBL 7.800000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome subunit alpha type-3 (SINGLE PROTEIN), Homo sapiens
UniProt: P25788
Assay: Binding affinity to human PSMA3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 8.403 nM (pChEMBL 8.079999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome subunit alpha type-3 (SINGLE PROTEIN), Homo sapiens
UniProt: P25788
Assay: Binding affinity to human PSMA3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 8.403 nM (pChEMBL 8.079999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome subunit alpha type-4 (SINGLE PROTEIN), Homo sapiens
UniProt: P25789
Assay: Binding affinity to human PSMA4 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 13041.3 nM (pChEMBL 4.880000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome subunit alpha type-4 (SINGLE PROTEIN), Homo sapiens
UniProt: P25789
Assay: Binding affinity to human PSMA4 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 13041.3 nM (pChEMBL 4.880000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome subunit alpha type-5 (SINGLE PROTEIN), Homo sapiens
UniProt: P28066
Assay: Binding affinity to human PSMA5 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 213855.86 nM (pChEMBL 3.6700000762939453)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome subunit alpha type-6 (SINGLE PROTEIN), Homo sapiens
UniProt: P60900
Assay: Binding affinity to human PSMA6 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 40.93 nM (pChEMBL 7.389999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome subunit alpha type-6 (SINGLE PROTEIN), Homo sapiens
UniProt: P60900
Assay: Binding affinity to human PSMA6 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 40.93 nM (pChEMBL 7.389999866485596)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome subunit alpha type-7 (SINGLE PROTEIN), Homo sapiens
UniProt: O14818
Assay: Binding affinity to human PSMA7 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 17545.73 nM (pChEMBL 4.760000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome subunit alpha type-7 (SINGLE PROTEIN), Homo sapiens
UniProt: O14818
Assay: Binding affinity to human PSMA7 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 17545.73 nM (pChEMBL 4.760000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome component C5 (SINGLE PROTEIN), Homo sapiens
UniProt: P20618
Assay: Binding affinity to human PSMB1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 76871.22 nM (pChEMBL 4.110000133514404)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome component C5 (SINGLE PROTEIN), Homo sapiens
UniProt: P20618
Assay: Binding affinity to human PSMB1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 76871.22 nM (pChEMBL 4.110000133514404)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome Macropain subunit (SINGLE PROTEIN), Homo sapiens
UniProt: P49721
Assay: Binding affinity to human PSMB2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 53.59 nM (pChEMBL 7.269999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome Macropain subunit (SINGLE PROTEIN), Homo sapiens
UniProt: P49721
Assay: Binding affinity to human PSMB2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 53.59 nM (pChEMBL 7.269999980926514)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome subunit beta type-3 (SINGLE PROTEIN), Homo sapiens
UniProt: P49720
Assay: Binding affinity to human PSMB3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 65.97 nM (pChEMBL 7.179999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome subunit beta type-3 (SINGLE PROTEIN), Homo sapiens
UniProt: P49720
Assay: Binding affinity to human PSMB3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 65.97 nM (pChEMBL 7.179999828338623)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome subunit beta type-4 (SINGLE PROTEIN), Homo sapiens
UniProt: P28070
Assay: Binding affinity to human PSMB4 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 30744.11 nM (pChEMBL 4.510000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome subunit beta type-4 (SINGLE PROTEIN), Homo sapiens
UniProt: P28070
Assay: Binding affinity to human PSMB4 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 30744.11 nM (pChEMBL 4.510000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome Macropain subunit MB1 (SINGLE PROTEIN), Homo sapiens
UniProt: P28074
Assay: Binding affinity to human PSMB5 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 1732.3 nM (pChEMBL 5.760000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome Macropain subunit MB1 (SINGLE PROTEIN), Homo sapiens
UniProt: P28074
Assay: Binding affinity to human PSMB5 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 1732.3 nM (pChEMBL 5.760000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome subunit beta type-6 (SINGLE PROTEIN), Homo sapiens
UniProt: P28072
Assay: Binding affinity to human PSMB6 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2680.95 nM (pChEMBL 5.570000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome subunit beta type-6 (SINGLE PROTEIN), Homo sapiens
UniProt: P28072
Assay: Binding affinity to human PSMB6 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2680.95 nM (pChEMBL 5.570000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome subunit beta type-7 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99436
Assay: Binding affinity to human PSMB7 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 254.86 nM (pChEMBL 6.590000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome subunit beta type-7 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99436
Assay: Binding affinity to human PSMB7 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 254.86 nM (pChEMBL 6.590000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome subunit beta type-8 (SINGLE PROTEIN), Homo sapiens
UniProt: P28062
Assay: Binding affinity to human PSMB8 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 9177.02 nM (pChEMBL 5.039999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome subunit beta type-8 (SINGLE PROTEIN), Homo sapiens
UniProt: P28062
Assay: Binding affinity to human PSMB8 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 9177.02 nM (pChEMBL 5.039999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome regulatory subunit 4 (SINGLE PROTEIN), Homo sapiens
UniProt: P62191
Assay: Binding affinity to human PSMC1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 4.772 nM (pChEMBL 8.319999694824219)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome regulatory subunit 4 (SINGLE PROTEIN), Homo sapiens
UniProt: P62191
Assay: Binding affinity to human PSMC1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 4.772 nM (pChEMBL 8.319999694824219)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome regulatory subunit 7 (SINGLE PROTEIN), Homo sapiens
UniProt: P35998
Assay: Binding affinity to human PSMC2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 232131.14 nM (pChEMBL 3.630000114440918)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome regulatory subunit 6A (SINGLE PROTEIN), Homo sapiens
UniProt: P17980
Assay: Binding affinity to human PSMC3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 4.973 nM (pChEMBL 8.300000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome regulatory subunit 6A (SINGLE PROTEIN), Homo sapiens
UniProt: P17980
Assay: Binding affinity to human PSMC3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 4.973 nM (pChEMBL 8.300000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome regulatory subunit 6B (SINGLE PROTEIN), Homo sapiens
UniProt: P43686
Assay: Binding affinity to human PSMC4 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 507.65 nM (pChEMBL 6.289999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome regulatory subunit 6B (SINGLE PROTEIN), Homo sapiens
UniProt: P43686
Assay: Binding affinity to human PSMC4 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 507.65 nM (pChEMBL 6.289999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome regulatory subunit 8 (SINGLE PROTEIN), Homo sapiens
UniProt: P62195
Assay: Binding affinity to human PSMC5 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 443.32 nM (pChEMBL 6.349999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome regulatory subunit 8 (SINGLE PROTEIN), Homo sapiens
UniProt: P62195
Assay: Binding affinity to human PSMC5 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 443.32 nM (pChEMBL 6.349999904632568)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome regulatory subunit 10B (SINGLE PROTEIN), Homo sapiens
UniProt: P62333
Assay: Binding affinity to human PSMC6 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 164.1 nM (pChEMBL 6.789999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome regulatory subunit 10B (SINGLE PROTEIN), Homo sapiens
UniProt: P62333
Assay: Binding affinity to human PSMC6 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 164.1 nM (pChEMBL 6.789999961853027)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome non-ATPase regulatory subunit 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99460
Assay: Binding affinity to human PSMD1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 4321.54 nM (pChEMBL 5.360000133514404)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome non-ATPase regulatory subunit 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q99460
Assay: Binding affinity to human PSMD1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 4321.54 nM (pChEMBL 5.360000133514404)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome non-ATPase regulatory subunit 11 (SINGLE PROTEIN), Homo sapiens
UniProt: O00231
Assay: Binding affinity to human PSMD11 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 144.72 nM (pChEMBL 6.840000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome non-ATPase regulatory subunit 11 (SINGLE PROTEIN), Homo sapiens
UniProt: O00231
Assay: Binding affinity to human PSMD11 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 144.72 nM (pChEMBL 6.840000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome non-ATPase regulatory subunit 12 (SINGLE PROTEIN), Homo sapiens
UniProt: O00232
Assay: Binding affinity to human PSMD12 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 50.36 nM (pChEMBL 7.300000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome non-ATPase regulatory subunit 12 (SINGLE PROTEIN), Homo sapiens
UniProt: O00232
Assay: Binding affinity to human PSMD12 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 50.36 nM (pChEMBL 7.300000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome non-ATPase regulatory subunit 13 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UNM6
Assay: Binding affinity to human PSMD13 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 58333.25 nM (pChEMBL 4.230000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome non-ATPase regulatory subunit 13 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UNM6
Assay: Binding affinity to human PSMD13 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 58333.25 nM (pChEMBL 4.230000019073486)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome non-ATPase regulatory subunit 14 (SINGLE PROTEIN), Homo sapiens
UniProt: O00487
Assay: Binding affinity to human PSMD14 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 10619.35 nM (pChEMBL 4.96999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome non-ATPase regulatory subunit 14 (SINGLE PROTEIN), Homo sapiens
UniProt: O00487
Assay: Binding affinity to human PSMD14 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 10619.35 nM (pChEMBL 4.96999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome non-ATPase regulatory subunit 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q13200
Assay: Binding affinity to human PSMD2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 14882.71 nM (pChEMBL 4.829999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome non-ATPase regulatory subunit 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q13200
Assay: Binding affinity to human PSMD2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 14882.71 nM (pChEMBL 4.829999923706055)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome non-ATPase regulatory subunit 3 (SINGLE PROTEIN), Homo sapiens
UniProt: O43242
Assay: Binding affinity to human PSMD3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 19.67 nM (pChEMBL 7.710000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome non-ATPase regulatory subunit 3 (SINGLE PROTEIN), Homo sapiens
UniProt: O43242
Assay: Binding affinity to human PSMD3 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 19.67 nM (pChEMBL 7.710000038146973)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome non-ATPase regulatory subunit 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q16401
Assay: Binding affinity to human PSMD5 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 0.486 nM (pChEMBL 9.3100004196167)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome non-ATPase regulatory subunit 5 (SINGLE PROTEIN), Homo sapiens
UniProt: Q16401
Assay: Binding affinity to human PSMD5 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 0.486 nM (pChEMBL 9.3100004196167)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome non-ATPase regulatory subunit 6 (SINGLE PROTEIN), Homo sapiens
UniProt: Q15008
Assay: Binding affinity to human PSMD6 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 48.35 nM (pChEMBL 7.320000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome non-ATPase regulatory subunit 6 (SINGLE PROTEIN), Homo sapiens
UniProt: Q15008
Assay: Binding affinity to human PSMD6 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 48.35 nM (pChEMBL 7.320000171661377)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome non-ATPase regulatory subunit 7 (SINGLE PROTEIN), Homo sapiens
UniProt: P51665
Assay: Binding affinity to human PSMD7 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 71.11 nM (pChEMBL 7.150000095367432)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome non-ATPase regulatory subunit 7 (SINGLE PROTEIN), Homo sapiens
UniProt: P51665
Assay: Binding affinity to human PSMD7 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 71.11 nM (pChEMBL 7.150000095367432)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome non-ATPase regulatory subunit 8 (SINGLE PROTEIN), Homo sapiens
UniProt: P48556
Assay: Binding affinity to human PSMD8 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 34.09 nM (pChEMBL 7.46999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome non-ATPase regulatory subunit 8 (SINGLE PROTEIN), Homo sapiens
UniProt: P48556
Assay: Binding affinity to human PSMD8 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 34.09 nM (pChEMBL 7.46999979019165)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome non-ATPase regulatory subunit 9 (SINGLE PROTEIN), Homo sapiens
UniProt: O00233
Assay: Binding affinity to human PSMD9 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 90 nM (pChEMBL 7.050000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: 26S proteasome non-ATPase regulatory subunit 9 (SINGLE PROTEIN), Homo sapiens
UniProt: O00233
Assay: Binding affinity to human PSMD9 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 90 nM (pChEMBL 7.050000190734863)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome activator complex subunit 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q06323
Assay: Binding affinity to human PSME1 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 2585.73 nM (pChEMBL 5.590000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome activator complex subunit 1 (SINGLE PROTEIN), Homo sapiens
UniProt: Q06323
Assay: Binding affinity to human PSME1 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 2585.73 nM (pChEMBL 5.590000152587891)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome activator complex subunit 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UL46
Assay: Binding affinity to human PSME2 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 9773.74 nM (pChEMBL 5.010000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome activator complex subunit 2 (SINGLE PROTEIN), Homo sapiens
UniProt: Q9UL46
Assay: Binding affinity to human PSME2 incubated for 45 mins by Kinobead based pull down assay
Measurement: ED50 = 9773.74 nM (pChEMBL 5.010000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32
Compound (SMILES): Cc1ccc(C(=O)Nc2cccc(C(F)(F)F)c2)cc1Nc1nc(-c2cccnc2)nc2nn(C)cc12
InChIKey: MWKSRKSEWLRPBL-UHFFFAOYSA-N
Target: Proteasome activator complex subunit 3 (SINGLE PROTEIN), Homo sapiens
UniProt: P61289
Assay: Binding affinity to human PSME3 incubated for 45 mins by Kinobead based pull down assay
Measurement: Kd = 55.25 nM (pChEMBL 7.260000228881836)
Descriptors: MW 503.49, ALogP 5.75, HBA 7, HBD 2, PSA 97.62, QED 0.32