Clinical trial NCT04633161: The Role of Muscle in Knee Stability
Official title: The Role of Quadriceps and Hamstring Muscles in Knee Stability During Single Leg Hop Landing in Patients With Anterior Cruciate Ligament Reconstruction
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Anterior Cruciate Ligament Injuries
Keywords: muscle strength
muscle elasticity
muscle coordination
knee stability
Lead sponsor: Chinese University of Hong Kong
Sponsor class: OTHER
First posted: 2020-11-18
Enrollment: 30
Sex: MALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Young and active ACL patients within their post-ACLR 6-18 months

Brief summary: This project aims to compare the difference in muscle strength, muscle elasticity and muscle coordination of quadriceps and hamstring muscle and their association with knee biomechanics during single leg hop landing in patients with anterior cruciate ligament reconstruction.

Detailed description: In Hong Kong, over 3000 cases of Anterior Cruciate Ligament Reconstruction (ACLR) are operated annually to restore knee stability. Despite recovery of knee passive laxity and muscle strength, dynamic knee stability is often not restored. In additional to muscle strength, muscle elasticity and muscle coordination may also play an important role in knee stability. However, there is no evidence regarding the changes in muscle elasticity after ACLR and its contribution to dynamic knee stability. This study is a cross-sectional study designed to compare the the difference in muscle strength, muscle elasticity and muscle coordination of quadriceps and hamstring muscle in 30 ACLR patients and investigate its relationship with knee biomechanics during single leg hop landing. Patient selection was base on medical records and subjective knee functional scores. Patient enrollment and informed consent was conducted first. Muscle strength was measured by isokinetic muscle testing(Biodex) at two speeds. Muscle elasticity was assessed by ultrasound shear wave elastography. Muscle coordination evaluated by electromyography(EMG) and knee biomechanics including kinematics and kinetics was measured by 3D motion analysis system(VICON) and all the assessments were done in CUHK-ORT Sports Injury Research Laboratory in the Prince of Wales Hospital, Hong Kong. All data was collected and analyzed by qualified personnel.

Eligibility criteria: Inclusion Criteria:

* (1) Male aged 18-35 (2) With pre-injury activity level of more than 6 in Tegner score (3) Within their post-operative 6-18 months (4) Without injury history for the contralateral limb

Exclusion Criteria:

* (1) With concomitant fracture, meniscus injury or chondral lesion (2) With preoperative radiographic signs of arthritis (3) With revision ACL surgery (4) With injury history of the spine or hamstring strain during the past 6 months.

Primary outcomes:
measure: knee biomechanics during single leg hop landing
timeFrame: post-operatively 6-18 months
measure: muscle strength
timeFrame: post-operatively 6-18 months
measure: muscle elasticity
timeFrame: post-operatively 6-18 months
measure: muscle coordination
timeFrame: post-operatively 6-18 months
Secondary outcomes:
measure: knee laxity
timeFrame: post-operatively 6-18 months
measure: subjective knee function
timeFrame: post-operatively 6-18 months
measure: Psychological readiness for return-to-play
timeFrame: post-operatively 6-18 months
Other outcomes:
Locations:
city: Hong Kong
country: Hong Kong
facility: The chinese University of Hong Kong
Study officials:
References: