Clinical trial NCT03282175: Effects of Elastic Resistance Training on Performance and Biochemical Parameters
Official title: Effects of Elastic Resistance Training on Physical Performance, Inflammatory Marker and Myokines in Elderly Women
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Exercise
Keywords: BDNF
interleukin-15
interleukin-8
resistin
SPPB
Lead sponsor: University of Primorska
Sponsor class: OTHER
First posted: 2017-09-13
Enrollment: 20
Sex: FEMALE
Minimum age (years): 65
Maximum age (years): 99
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this study was to investigate the acute and chronic effect of elastic resistance exercise in elderly women living in a nursing home. The primary outcome was the functional performance and hand grip strength. The secondary outcomes were myokines and inflammatory markers analysis.

Detailed description: Evidence regarding the relationship between RT and systemic myokine responses, as well as inflammation and physical performance in elderly is limited. Thus, this study aimed to evaluate the effect of short-term progressive elastic resistance training on muscular strength and physical performance, as well as the acute and chronic response of myokines and inflammatory markers after resistance exercise in elderly women living in a nursing home. From January to February 2016, we invited 95 older women (≥ 65 years) living in nursing home in the south of Slovenia to participate in our study.

The experimental design consisted of 1) baseline testing; 2) acute elastic resistance exercises with post-exercise and 2h post-exercise biochemical analysis; 3) a 3 months of supervised, progressive elastic resistance training program of moderate intensity; and 4) post-training testing.

The quantification of biomarkers was done using the MAGPIX® system, magnetic bead-based multi-analyte panels and MILLIPLEX® Analyst 5.1 software (MAGPIX®, Merck Millipore) and a human premixed 4-plex kit (R\&D System Inc., Minneapolis, MN, USA), strictly following the manufacturer's instructions.

Two-way mixed ANOVA model was used to test group × time interaction. Tukey's post hoc test was applied for statistically significant interaction. To test for significant differences between groups relating anthropometric and biochemical variables, we used a Student's t-test. All values are expressed as mean and standard deviation (SD). P values of \<0.05 is considered statistically significant. Bonferroni's correction for multiple testing will be performed by multiplying the P value with the number of tests where appropriate. Statistical analyses will be carried out using the SPSS program, version 21 (Chicago, IL).

Eligibility criteria: Inclusion Criteria:

* nursing home residents
* participants did not perform any regular resistance training

Exclusion Criteria:

* immobility
* implantable cardiac peacemaker
* severe dementia
* terminal illness

Primary outcomes:
measure: Functional performance
timeFrame: 1 week
Secondary outcomes:
measure: Acute effect of resistance exercise
timeFrame: 4 hours
measure: Biochemical analysis of chronic effect of resistance training
timeFrame: 2 weeks
Other outcomes:
Locations:
Study officials:
affiliation: University of Primorska Faculty of Mathematics, Natural Sciences and Information Technologies
name: Felicita Urzi, MSc
role: PRINCIPAL_INVESTIGATOR
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