Clinical trial NCT06202183: Exercise for Gut Microbiome in Patients With Young-Onset Colorectal Cancer Undergoing Chemotherapy: The COURAGE Trial
Official title: Exercise for Gut Microbiome in Patients With Young-Onset Colorectal Cancer Undergoing Chemotherapy: The COURAGE Trial
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Colorectal Cancer
Metastatic Colon Cancer
Metastatic Colorectal Cancer
Keywords: Colorectal Cancer
Metastatic Colon Cancer
Metastatic Colorectal Cancer
Early Stage Colorectal Cancer
Lead sponsor: Dana-Farber Cancer Institute
Sponsor class: OTHER
Collaborators: name: American Cancer Society, Inc.
First posted: 2024-01-11
Enrollment: 84
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: This research study is a randomized controlled trial that will observe changes in microbiome activity, changes in chemotherapy toxicity, and any changes in treatment outcomes between two groups of participants undergoing chemotherapy with either early-stage or metastatic colorectal cancer.

The names of the study groups involved in this study are:

* Exercise
* Waitlist Control

Detailed description: This research study is a single-center, two-armed, randomized controlled trial that will observe changes in microbiome activity, changes in chemotherapy toxicity, and any changes in treatment outcomes between two groups of participants undergoing chemotherapy with either early-stage or metastatic colorectal cancer. Participants will be randomly assigned to one of two groups: Group A: Exercise group (EXE) vs. Group B: Waitlist control group (WC). Randomization means that a participant will be placed into one of the study groups by chance.

The research study procedures include screening for eligibility, blood tests, stool samples, and survey questionnaires.

Participation in this research study will last up to 6 months.

It is expected that about 84 people will take part in this research study.

The American Cancer Society is providing funding for this research study.

Eligibility criteria: Inclusion Criteria:

* Patient diagnosed with early-stage or metastatic colon or rectal cancer
* Age at diagnosis 18-50 years; due to the specificity of the study question those outside the age bracket will not be included
* No plans for major surgical intervention at the time of recruitment for a minimum of 12 weeks (i.e. study period; placement of port a cath is allowed)
* No plans for radiation therapy at the time of recruitment for a minimum of 12 weeks
* Within the first four weeks of starting chemotherapy
* Participate in less than or equal to 90 minutes of moderate-to-vigorous exercise per week
* Medical clearance to perform exercise intervention and testing by their treating oncologist
* No uncontrolled medical conditions that could be exacerbated with exercise
* Ability to communicate and complete written forms in English
* Ability to understand and the willingness to sign informed consent prior to any study-related procedures
* Willing to travel to DFCI for necessary data collection

Exclusion Criteria:

* Participate in more than 90 minutes of moderate-to-vigorous aerobic exercise per week over the past month. This study targets insufficiently active persons to assess the effect of the described exercise intervention, where additional exercise done regularly will contaminate the intervention effects.
* Unstable comorbidities that prevent participation in moderate-to-vigorous intensity exercise. Patients with unstable comorbidities may develop unexpected adverse events from exercise. For the purpose of patients' safety, as well as because this study involves remote, home-based exercise where close supervision is not possible, patients with unstable medical conditions are excluded.
* Subjects who in the opinion of the investigator may not be able to comply with the safety monitoring requirements of the study.

Primary outcomes:
measure: Gut Microbiome Genomes
timeFrame: Baseline (Week 1) and Post-intervention (Week 13)
Secondary outcomes:
measure: Change in Chemotherapy Toxicity
timeFrame: 12 weeks
Other outcomes:
Locations:
city: Boston
country: United States
facility: Dana Farber Cancer Institute
state: Massachusetts
Study officials:
affiliation: Dana-Farber Cancer Institute
name: Christina Dieli-Conwright, MPH, PhD
role: PRINCIPAL_INVESTIGATOR
References: