louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03544307: Taekwondo Training and Postmenopausal Women With Stage-2 Hypertension
Official title: Taekwondo Training Reduces Blood Catecholamine Levels and Arterial Stiffness in Postmenopausal Women With Stage-2 Hypertension
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Menopause
Hypertension
Keywords: Taekwondo
Menopause
Hypertension
Arterial Stiffness
Blood Catecholamines
Lead sponsor: Kosin University
Sponsor class: OTHER
Collaborators: name: University of Nebraska
First posted: 2018-06-01
Enrollment: 20
Sex: FEMALE
Minimum age (years): 65
Maximum age (years): 85
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Parallel design with treatment group and control
Primary purpose: TREATMENT

Brief summary: Aging is associated with hormonal imbalances and progressive decreases in arterial health and function. It is crucial to prevent or reduce the negative effects of aging on hormonal balance and the vasculature by implementing appropriate lifestyle interventions, such as exercise training. We examined the effects of a 12-week Taekwondo training program on blood catecholamines, arterial stiffness (pulse wave velocity, PWV), blood pressure (BP), resting heart rate, and muscular strength in postmenopausal women with stage 2 hypertension.

Detailed description: Using a parallel experimental design, participants were randomly assigned to either a Taekwondo exercise training group (n=10) or non-exercising control group (n=10) for 12 weeks.

Participant in the Taekwondo training group trained 3 days/week for 60 minutes per session, and the intensity progressed weekly. Participants in the control group performed no exercise intervention.

Eligibility criteria: Inclusion Criteria:

* Be diagnosed with stage-2 hypertension
* Be postmenopausal
* Be between 65 and 85 years old

Exclusion Criteria:

* Known cardiovascular, metabolic or renal diseases
* Physical limitations that prohibit exercise
* Participates in regular exercise

Primary outcomes:
measure: Blood Epinephrine Levels
timeFrame: 12-weeks
measure: Blood Norepinephrine Levels
timeFrame: 12-weeks
Secondary outcomes:
measure: Arterial Stiffness
timeFrame: 12-weeks
measure: Systolic Blood Pressure
timeFrame: 12-weeks
measure: Hand Grip Strength
timeFrame: 12-weeks
measure: Diastolic Blood Pressure
timeFrame: 12-weeks
measure: Leg Strength
timeFrame: 12-weeks
Other outcomes:
Locations:
city: Omaha
country: United States
facility: University of Nebraska Omaha
state: Nebraska
Study officials:
affiliation: University of Nebraska
name: Song Park
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01261507: Reader Study of DeltaView™ Chest Radiograph Software
Official title: Reader Study to Demonstrate That Use of DeltaView™ is Superior to the Use Standard Prior and Current Antero/Posterior (AP/PA) X-ray Image Pair
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Lung Neoplasm
Keywords: lung neoplasm nodule image processing computer-assisted
Lead sponsor: Georgetown University
Sponsor class: OTHER
Collaborators: name: Riverain Medical Group, Miamisburg, OH
name: BioStat Solutions, Inc., Mt. Airy, MD
First posted: 2010-12-16
Enrollment: 15
Sex: ALL
Minimum age (years): 35
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Radiologists in community practice of radiology chest radiographs of individuals with or without a lung nodule

Brief summary: A new software product takes two chest radiographs, aligns them, and then subtracts one image from the other. The resulting image represents an image showing any differences between them. The study is to determine whether radiologists using this new software perform better with it than when they do not use it.


Eligibility criteria: Inclusion Criteria:

For Radiologists: American Board of Radiology Certification and live within the Baltimore, MD-Washington, DC Metropolitan areas

For chest radiographs, evidence of the presence or absence of lung nodule confirmed by expert panel; adequate image quality

-

Exclusion Criteria:

Radiologists who assisted by providing cases for review

For chest radiographs: poor image quality

Primary outcomes:
measure: Localized Receiver Operating Characteristic (LROC) Comparison
timeFrame: 1 day
Secondary outcomes:
measure: Sensitivity and Specificity
timeFrame: 1 day
measure: False Positive Decisions of Radiologists
timeFrame: 1 day
Other outcomes:
Locations:
city: Washington
country: United States
facility: ISIS Research Center, Georgetown University Medical Center
state: District of Columbia
Study officials:
affiliation: Georgetown University
name: Matthew T Freedman, MD, MBA
role: PRINCIPAL_INVESTIGATOR
affiliation: Georgetown University
name: S.-C. Ben Lo, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01418807: Transumbilical Versus Transvaginal Specimen Retrieval at Minilaparoscopy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
PHASE3
Conditions: Postoperative Pain
Patients Satisfaction
Intraoperative Complications
Postoperative Complications
Lead sponsor: Università degli Studi dell'Insubria
Sponsor class: OTHER
First posted: 2011-08-17
Enrollment: 56
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: We hypothesise that pain at minilaparoscopy for gynecologic disease is reduced when transvaginal rather than transumbilical specimen extraction is accomplished. This would be due to the avoidance of a 10-mm port in the umbilicus. Visual analogue scale score of post-operative pain will be obtained and patients satisfaction will be asked at the 2-month postoperative visit.


Eligibility criteria: Inclusion Criteria:

* Adnexal Mass
* Benign Gynecologic Condition
* Laparoscopicb Surgery

Exclusion Criteria:

* Obliteration Of The Douglas Pouch

Primary outcomes:
measure: Postoperative Pain
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Varese
country: Italy
facility: Department of Obstetrics and Gynecology Universita' Dell'Insubria
Study officials:
References:
Clinical trial NCT00633607: Hereditary Colorectal and Associated Tumor Registry Study
Official title: Hereditary Colorectal and Associated Tumor Registry Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Lynch Syndrome
FAP
Hereditary Diffuse Gastric Cancer
Juvenile Polyposis Syndrome
Peutz-Jeghers Syndrome
Lead sponsor: University of Pittsburgh
Sponsor class: OTHER
First posted: 2008-03-12
Enrollment: 114
Sex: ALL
Minimum age (years): 8
Maximum age (years): 100
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: FAMILY_BASED
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Potential research subjects are recruited from our Hereditary GI clinic.

Brief summary: After informed consent, participants will be asked to complete a medical/family history questionnaire and provide a blood sample. Participants will also be asked for their permission for study investigators to access medical records and/or recontact them for updates to their medical and family histories. Data and biospecimens will be stored for potential future research projects.


Eligibility criteria: Inclusion Criteria:

* Identified gene mutation
* Personal history of colorectal cancer diagnosed ≤ 50
* Personal history of cancer with tumor studies suggestive of Lynch syndrome
* Personal history of multiple primary tumors associated with a hereditary cancer syndrome (colorectal, uterus, stomach, ovary, small bowel, hepatobiliary tract, transitional cell carcinoma of the renal pelvis/ureter, brain)
* Personal history of one of the above cancers and a family history of one or more of the above cancers
* Personal or family history of diffuse gastric cancer
* From a known genetic predisposition family
* Personal history of \> 10 colon adenomas (cumulative over a lifetime)
* Personal history of any number of hamartomatous polyps
* Personal history of multiple large (\> 1cm) serrated polyps to right of sigmoid

Exclusion critera:

* Individuals under the age of 8
* Individuals who cannot travel to Pittsburgh for in-person enrollment
* Individuals who cannot provide informed consent

Primary outcomes:
measure: Establish a Hereditary Colorectal Tumor Registry to facilitate development and implementation of epidemiological, clinical and cancer control research.
timeFrame: 1-N/A (up to 8 years)
Secondary outcomes:
Other outcomes:
Locations:
city: Pittsburgh
country: United States
facility: University of Pittsburgh
state: Pennsylvania
Study officials:
affiliation: University of Pittsburgh
name: Randall E Brand, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00363207: Behavior of Children Related to Numbness After Dental Local Anesthesia
Official title: Behavior of Children in the Following Appointment Related to Numbness Perception After Dental Local Anesthesia
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Anesthesia, Local
Anesthesia, Dental
Keywords: behavior
local anesthesia
behavior after dental local anesthesia
Lead sponsor: Hadassah Medical Organization
Sponsor class: OTHER
First posted: 2006-08-15
Enrollment: 100
Sex: ALL
Minimum age (years): 4
Maximum age (years): 8
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: CASE_CROSSOVER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: children receiving routine dental treatment at the hadassah school of dental medicine

Brief summary: In children, behavior management is critical to the success of pediatric dental procedures. Most of the studies on local anesthesia performed in children deal with the question how to avoid or minimize pain during injection. Due to the sensation of numbness children scratch the soft tissues and bite lips and tongue. In many cases, this may be kept in children's memory as a "painful experience" and may affect their behavior in the following visit. The purpose of this study is to evaluate children's reactions to the administration of local anesthetic injection in the mandible (mandibular block) and in the maxilla (supraperiosteal infiltration), and to assess their behavior in the following visit related to each type of injection.

Detailed description: Children between the ages of 4 to 7, undergoing dental treatment at the Department of Pediatric dentistry of the Hadassah School of Dental Medicine will participate in the study. All patients should be ASA Class I with no prior dental treatment who need at least two clinical sessions of similar operative procedures preceded by local anesthetic injection, one in each jaw, none of which due to emergency. Subjective and objective evaluation will be performed according to previously validated scales.

Eligibility criteria: Inclusion Criteria:

* Age: 4-7
* Behavior: Frankel 3-4
* No sedation (premedication)
* ASA 1
* No dental treatment before
* Need for similar treatment in the upper and lower jaw
* No emergency treatment

Exclusion Criteria:

* Need of premedication
* Uneven treatment in each jaw

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Jerusalem
country: Israel
facility: Hadassah Medical Organization
city: Jerusalem
country: Israel
facility: Hadassah School of Dental Medicine
Study officials:
affiliation: Hadassah Medical Organization
name: Diana Ram, Dr
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05593107: 68Ga-N188 PET/CT Imaging in Malignancy
Official title: A Study to Evaluate 68Ga-N188 PET/CT Imaging of Nectin-4 Expression in Malignant Tumors
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Neoplasms
Keywords: [68Ga]N188
Nectin-4
PET/CT
Neoplasms
Lead sponsor: Peking University First Hospital
Sponsor class: OTHER
First posted: 2022-10-25
Enrollment: 203
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The Nectin-4 protein belongs to the cell adhesion factors family and has a tissue-specific expression spectrum in normal human tissues. However, Nectin-4 is overexpressed in various malignancies, especially those of epithelial origins, such as uroepithelial carcinoma, making Nectin-4 a highly specific and significant imaging target for malignancies.

\[68Ga\]N188, a novel molecular probe of PET imaging agent that targets Nectin-4, can be used in the diagnosis and research of a wide variety of Nectin-4 high-expression malignancies, including bladder cancer.


Eligibility criteria: Inclusion Criteria:

* patients with confirmed or suspected cancer;
* 18F-FDG PET/CT within 1 week;
* Signed written informed consent.

Exclusion Criteria:

* Pregnant and lactating women;
* Female patients plan to become pregnant within 6 months.

Primary outcomes:
measure: The diagnostic efficacy of 68Ga-N188 PET/CT in the evaluation of malignant tumors
timeFrame: 1 year
measure: The diagnostic efficacy of 68Ga-N188 PET/CT in the evaluation of malignant tumors
timeFrame: 1 year
Secondary outcomes:
measure: The dosimetry of 68Ga-N188
timeFrame: 1 year
measure: Quantitative evaluation of 68Ga-N188
timeFrame: 1 year
measure: Correlation with pathological expression
timeFrame: 1 year
Other outcomes:
Locations:
city: Beijing
country: China
facility: Peking University First Hospital
state: Beijing
Study officials:
References:
Clinical trial NCT02547207: MultiPoint Pacing Mapping Study
Official title: MultiPoint Pacing Mapping Study
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Heart Failure
Lead sponsor: Abbott Medical Devices
Sponsor class: INDUSTRY
First posted: 2015-09-11
Enrollment: 7
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Heart failure patients meeting specific eligibility criteria

Brief summary: The purpose of this study is to characterize left ventricular acute hemodynamic and electrical responses during cardiac resynchronization therapy (CRT) with different Multipoint Pacing (MPP) settings, and assess the relationship between electrical activation patterns and hemodynamic measurements during these pacing settings.


Eligibility criteria: Inclusion Criteria:

* Be scheduled to undergo or have received within the past 30 days an implant of a SJM (St. Jude Medical) MPP CRT-D system with approved standard indication by ESC (European Society of Cardiology) / EHRA (European Heart Rhythm Association) Guidelines
* Have the ability to provide informed consent for study participation and be willing and able to comply with the Clinical Investigation Plan (CIP) described evaluations and follow-up schedule
* Be in sinus rhythm

Exclusion Criteria:

* Complete AV (atrioventricular) block
* Permanent atrial fibrillation
* Have a recent myocardial infarction within 40 days prior to enrollment
* Have undergone cardiac surgery or coronary revascularization procedure within 3 months prior to enrollment or be scheduled for such procedures in the following 7 months
* Have had a recent CVA (cerebrovascular accident) or TIA (transient ischemic attack) within 3 months prior to enrollment
* Have had intravenous inotropic support in the last 30 days
* Be less than 18 years of age
* Be pregnant or plan to become pregnant over the next 7 months
* Have significant peripheral vascular disease
* Have LV thrombus
* Significant aortic valve disease or replacement
* Mitral valvular disease
* Contraindicated for Gadolinium contrast agent

Primary outcomes:
measure: Left ventricular (LV) dP/dt Max (maximum change in pressure over time) in mmHg/s during different pacing settings
timeFrame: up to 30 days post-implant
Secondary outcomes:
Other outcomes:
Locations:
city: Rennes
country: France
facility: CHU Pontchaillou
city: Bad Nauheim
country: Germany
facility: Kerckhoff-Klinik GmbH
city: Dresden
country: Germany
facility: Herzzentrum Dresden Universitätsklinik
city: London
country: United Kingdom
facility: St. Thomas Hospital
Study officials:
affiliation: University Hospital Rennes, Rennes, France
name: Christophe Leclercq, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03056807: Evaluation of Apnea Tolerance in Bariatric Patients Following Rapid-sequence Induction of Anesthesia
Official title: Evaluation of Apnea Tolerance in Bariatric Patients Following Rapid-sequence Induction of Anesthesia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: General Surgery
Keywords: tolerable apneic time
bariatric surgery
gastric band surgery
intubation
Lead sponsor: University of Kansas Medical Center
Sponsor class: OTHER
First posted: 2017-02-17
Enrollment: 65
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The purpose of this study is to compare the effect of the 25° head-up position versus the 55° head-up position on tolerable apneic time (TAT) in bariatric patients scheduled for laparoscopic adjustable gastric band surgery following maximum preoxygenation and rapid-sequence induction (RSI) of anesthesia.


Eligibility criteria: Inclusion Criteria:

* American Society of Anesthesiologists (ASA) physical status II-III patients
* Body Mass Index (BMI) of 40-60
* Scheduled for an elective laparoscopic adjustable gastric band surgery

Exclusion Criteria:

* Patients with abnormalities of the upper airway that require awake tracheal intubation
* Asthma
* Chronic obstructive pulmonary disease
* Pregnant patients

Primary outcomes:
measure: Tolerable Apneic Time (TAT)
timeFrame: Time between start of induction of general anesthesia (SpO2 100%) to decline of SpO2 94%, up to eight minutes
Secondary outcomes:
measure: Length of time to intubation (TTI)
timeFrame: Time between start of the tracheal intubation procedure to completion of tracheal intubation, up to 2 minutes
measure: Peripheral arterial hemoglobin oxygen saturation (SpO2) trough
timeFrame: Time until SpO2 decreased to 92%, up to 8 minutes
Other outcomes:
Locations:
city: Kansas City
country: United States
facility: University of Kansas Medical Center
state: Kansas
Study officials:
affiliation: University of Kansas Medical Center
name: Mirsad Dupanović, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00888407: Community-based Hepatitis B Interventions for Hmong Adults
Official title: Community-based Hepatitis B Interventions for Hmong Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Liver Cancer
Keywords: Asian American Health
Cancer
Hepatitis
Hepatitis B
Liver Cancer
Lead sponsor: University of California, Davis
Sponsor class: OTHER
Collaborators: name: National Institutes of Health (NIH)
name: National Cancer Institute (NCI)
First posted: 2009-04-27
Enrollment: 1500
Sex: ALL
Minimum age (years): 18
Maximum age (years): 64
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to design an intervention to increase hepatitis B (HBV) screening among Hmong Americans.

Detailed description: The investigators will design an intervention to measure the baseline proportion of Hmong adults (ages 18-64) that have been serologically tested for Hepatitis B. Investigators will work with lay health workers to promote serologically testing for Hepatitis B and increase knowledge of Hepatitis B among Hmong adults. The effectiveness of the lay health worker intervention will be evaluated by conducting a randomized, controlled trial among Hmong adults aged 18-64 not previously tested for hepatitis B.

The primary hypothesis is that the proportion of Hmong adults, ages 18-64 reporting serologically testing for Hepatitis B at post-test will be significantly greater in the intervention group than in the control group.

Secondary hypotheses are:

There will be greater increases in knowledge of Hepatitis B and liver cancer in the intervention group than in the control group.

Participants with greater knowledge of hepatitis B and liver cancer at post-test will be more likely to be serologically tested for hepatitis B.

Eligibility criteria: Inclusion Criteria:

* Ages 18-64 years
* Hmong ancestry
* Never have been tested for Hepatitis B

Exclusion Criteria:

* Children under the age of 18 years
* Adults over the age of 64 years
* Non-Hmong ancestry
* Previous testing of Hepatitis B

Primary outcomes:
measure: Obtain HBV Screening Test
timeFrame: September 2006-August 2011
Secondary outcomes:
measure: Knowledge and Attitudes Regarding Hepatitis B, Health and Nutrition
timeFrame: September 206 - August 2011
Other outcomes:
Locations:
city: Sacramento
country: United States
facility: UC Davis Cancer Center
state: California
Study officials:
affiliation: University of California, Davis
name: Moon S. Chen, Jr., PhD, MPH
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00306007: Evaluation of the Reliability, Validity, and Acceptability of the London Measure of Unplanned Pregnancy in a U.S. Population of Women
Official title: Evaluation of the Reliability, Validity, and Acceptability of the London Measure of Unplanned Pregnancy in a U.S. Population of Women
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Unplanned Pregnancy
Keywords: Pregnancy
Unplanned pregnancy
Psychosocial
Measure
Lead sponsor: University of California, San Francisco
Sponsor class: OTHER
First posted: 2006-03-22
Enrollment: 320
Sex: FEMALE
Minimum age (years): 15
Maximum age (years): 45
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: target population for this study is pregnant women who present to san Francisco General Hospital (SFGH) Women's Options Center (WOC) for abortion and to the Women's Health Center for prenatal care. The population is racially and ethnically diverse, and the majority are financially challenged and have no insurance or Medicaid.

Brief summary: The aim of the study is to evaluate the reliability, validity, and acceptability of the London Measure of Unplanned Pregnancy (LMUP) in a U.S. population of women. The researchers hypothesize that the LMUP will be acceptable to a U.S. population and will be reliable and valid.

Detailed description: The concept of "unplanned pregnancy" is used frequently in health research and policy. The majority of tools used to assess unplanned pregnancy planning have not been validated. Recently the London Measure of Unplanned Pregnancy (LMUP) has been developed and validated. The LMUP had been found to be valid and reproducible, but has not been studied outside of the United Kingdom. If we are able to validate this measure in a U.S. population, its use in studies will improve the quality of data about family planning in U.S. women.

Eligibility criteria: Inclusion Criteria:

* Pregnant women
* Basic literacy in English or Spanish needed to participate.

Exclusion Criteria:

* Literacy level lower than 11 years of age

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: San Francisco
country: United States
facility: San Francisco General Hospital
state: California
Study officials:
affiliation: University of California, San Francisco
name: Jody Steinauer, MD, MAS
role: PRINCIPAL_INVESTIGATOR
affiliation: University of California, San Francisco
name: Diane Morof, MD, MSc
role: STUDY_DIRECTOR
References: