Clinical trial NCT00574483: Treatment of Advanced Renal Cell Carcinoma With Quinacrine
Official title: An Open-label, Fixed-dose, Clinical Study of Quinacrine Safety and Efficacy in the Treatment of Advanced Renal Cell Carcinoma
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: PHASE2
Conditions: Renal Cell Carcinoma
Keywords: Renal cell carcinoma
Lead sponsor: Cleveland BioLabs
Sponsor class: INDUSTRY
First posted: 2007-12-17
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The overall response to standard therapies and to the newer antiangiogenesis therapies is not curative, and treatment-associated toxicities may be severe. Therefore, continued evaluation of therapies, with different mechanisms of action, is needed for patients with metastatic RCC.

Detailed description: Approximately 31,000 new cases of renal cell carcinoma (RCC) occur each year in the United States, with a death rate of about 11,600 annually. Many patients present with advanced or unresectable disease, and up to 30% of patients who are treated with nephrectomy will relapse. The 5 year survival rate for metastatic renal RCC is estimated at \< 10%. Surgical resection of discernible disease is the only potentially curative treatment. No significant improvement in survival has been demonstrated for patients with metastatic RCC who have been treated with systemic hormonal, chemotherapeutic, and radiation therapy. Interferon alpha has about a 15% objective response rate in appropriately selected patients. Administration of interleukin 2 (IL 2) has shown a similar response rate; however, approximately 5% of highly selected patients had durable complete remissions.

Recent studies demonstrated that RCC cells harbor abnormalities of the von Hippel-Lindau (VHL) gene, playing a key role in the stimulation of angiogenesis by vascular endothelial growth factor (VEGF) in this highly vascularized tumor. The novel agents sunitinib (Sutent) and sorafenib (Nexavar) are approved by the US Food and Drug Administration (FDA) for the treatment of advanced RCC, and both bevacizumab (Avastin) and temsirolimus have shown significant activity in treatment-naïve patients. Prolonged progression-free survival has been reported with sorafenib and sunitinib in randomized, controlled phase 2 and 3 studies, and improved survival has been reported with temsirolimus in poor-risk patients in a phase 3 randomized study.

Eligibility criteria: Inclusion Criteria:

* Confirmed RCC with clear cell predominance.
* Subjects must provide written informed .
* Subjects must be at least 18 years old.
* Subjects must have at least 1 measurable lesion.
* Subjects must have metastatic, locally advanced or unresectable RCC.
* Subjects must have received ≥ 1 prior systemic regimen for RCC.
* All prior cancer therapy, including radiation, surgery, and systemic (hormonal, chemotherapeutic, and immunotherapeutic) therapy, must be completed at least 4 weeks before the baseline visit.
* Subjects must be capable of adhering to the study visit schedule and other protocol requirements.
* Subjects must have an Eastern Cooperative Oncology Group (ECOG) performance status of 0 to 2.
* Subjects must have:

  1. Absolute neutrophil count (ANC)\> 1,500/uL
  2. Hemoglobin \> 10.0 g/dL
  3. Platelets ≥ 100,000/uL
  4. Serum creatinine \< 2.0 mg/dL
* Subjects must have adequate hepatic function, as defined by a bilirubin level of ≤ 1.5 times the upper limit of the normal range (ULN) and an aspartate aminotransferase (AST) or alanine aminotransferase (ALT) level of ≤ 3 times the ULN (or ≤ 5 times the ULN if liver metastases are present).
* Women of childbearing potential must have a negative serum pregnancy test at the screening visit and throughout the study.
* Sexually active women and men must agree to use a medically acceptable form of contraception.

Exclusion Criteria:

* Subjects who have a history of any malignancy (other than excised basal cell carcinoma or cervical intraepithelial neoplasia) within the 5 years of baseline visit.
* Subjects who have received any anticancer agents, treatment (chemotherapy, targeted agents, radiation, hormones), or investigational agents within 30 days of the baseline visit.
* Subjects who have untreated brain metastases.
* Subjects who have a history of hypersensitivity reaction to quinacrine or other acridine derivatives (e.g. Cognex).
* Subjects who have any clinically significant hematological, endocrine, cardiovascular (including any rhythm disorder), renal, hepatic, gastrointestinal (GI), or neurological disease (including any history of seizure).
* Subjects who have a history of porphyria or psoriasis.
* Subjects who have documented glucose-6-phosphate dehydrogenase deficiency.
* Subjects who have a history of noninfectious (toxic, autoimmune) hepatitis.
* Subjects who have a history of schizophrenia, bipolar disorder, or any psychiatric illness/social situations that would limit compliance with study requirements.
* Subjects who have a history of dermatitis as an allergic/toxic reaction to any medication.
* Subjects who have any grade 2 sensory neuropathy.
* Subjects who have a QTcF (Fredericia) of \> 450 msec.
* Subjects who have New York Heart Association (NYHA) class 3 or 4 heart failure.
* Subjects who had a myocardial infarction or acute coronary syndrome within 6 months of the baseline visit.
* Subjects who require anti-arrhythmic treatment with amiodarone or any drug with a quinidine-like effect on the heart or who have history of a malignant ventricular arrhythmia unless they have a functioning Automatic Implantable Cardio-Defibrillator (AICD) implanted.
* Subjects who are immunocompromised, including those known to be human immunodeficiency virus (HIV) positive, hepatitis B positive, or hepatitis C positive.

Primary outcomes:
measure: Tumor response
timeFrame: 6 months
Secondary outcomes:
measure: Time to tumor progression
timeFrame: 6 months
Other outcomes:
Locations:
city: Albany
country: United States
facility: Community Care Physicians
state: New York
city: Charlotte
country: United States
facility: ClinWorks Cancer Research Center
state: North Carolina
Study officials:
affiliation: Cleveland BioLabs
name: John H Gordon, PhD
role: STUDY_DIRECTOR
References: