Clinical trial NCT07010783: Respiratory Functions in Parkinson's Disease
Official title: Investigation of Respiratory Functions, Inspiratory Muscle Strength, Physical Fitness and Aerobic Capacity in Patients With Parkinson's Disease
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Parkinson Disease
Lead sponsor: Ankara University
Sponsor class: OTHER
Collaborators: name: Hacettepe University
name: Atılım University
First posted: 2025-06-08
Enrollment: 100
Sex: ALL
Minimum age (years): 50
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with Parkinson's disease who came to the neurology outpatient clinic for routine examination and who met the appropriate inclusion criteria and healthy individuals with similar demographic characteristics.

Brief summary: The aim is to examine respiratory functions, inspiratory muscle strength, respiratory function, physical fitness and aerobic capacity in Parkinson's disease patients. Individuals between the ages of 50-80 who have been diagnosed with Parkinson's disease by a neurologist and healthy individuals with similar demographic characteristics will be included in the study as a control group. In addition, patients will be divided into three groups as above and below 2.5 and healthy controls according to the Modified Hoehn and Yahr Scale. Demographic information of the individuals will be recorded and clinical evaluations will be made. The staging of Parkinson's patients will be done with the Modified Hoehn and Yahr Scale, and the severity of the disease will be done with the Unified Parkinson's Disease Rating Scale. The inspiratory muscle strength of the individuals will be evaluated with the PowerBreath K5, respiratory functions with the Pulmonary Function Test device, and physical fitness and aerobic capacity with the Senior Fitness Test.


Eligibility criteria: Inclusion Criteria:

* Age 50 to 80
* Mini Mental State Examination score of 24 to 30
* Diagnosed with Parkinson's Disease by a neurologist

Exclusion Criteria:

* Sözlü iletişim kuramama
* Yürüme yardımcısı kullanıma
* Ciddi görme bozukluğu, ek nörolojik bozuklukları ve/veya konjestif kalp yetmezliği olan yaşlılar
* Egzersiz yapılması tavsiye edilmeyen yaşlı yetişkinler.

Primary outcomes:
measure: Inspiratory Muscle Strength Measurement
timeFrame: Baseline
measure: Unified Parkinson's Disease Rating Scale
timeFrame: Baseline
measure: Evaluation of Respiratory Functions
timeFrame: Baseline
measure: Senior Fitness Test
timeFrame: Baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Atılım University
Study officials:
affiliation: Atılım University
name: Süleyman Korkusuz, PhD
role: STUDY_CHAIR
affiliation: Hacettepe University
name: Ayla Fil Balkan, Assoc Prof
role: STUDY_CHAIR
affiliation: Hacettepe University
name: Gül Yalçın Çakmaklı, Assoc Prof
role: STUDY_CHAIR
affiliation: Baskent University
name: Neslihan Durutürk, Prof.Dr
role: STUDY_CHAIR
References:
citation: Shill H, Stacy M. Respiratory function in Parkinson's disease. Clin Neurosci. 1998;5(2):131-5.
citation: Morris ME, Iansek R, Matyas TA, Summers JJ. Ability to modulate walking cadence remains intact in Parkinson's disease. J Neurol Neurosurg Psychiatry. 1994 Dec;57(12):1532-4. doi: 10.1136/jnnp.57.12.1532.