louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06958575: Outcomes Assessment of Septal Extension Graft Versus Columellar Strut Graft in Rhinoplasty.
Official title: Outcomes Assessment of Septal Extension Graft Versus Columellar Strut Graft in Rhinoplasty.
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Septal Extension Graft in Rhinoplasty
Keywords: Rhinoplasty
Septal extension graft
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2025-05-06
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Nose is an important aesthetic landmark with its length, width, shape, and position in the middle of the face. Rhinoplasty is now one of the most common rhinological procedures with both functional and aesthetic aspects. Tip plasty is considered the core of rhinoplasty. The interaction among lower lateral cartilages, septal cartilage, adjacent soft tissues, tissue dynamics, and surgical techniques determines the nasal tips projection, rotation, and overall shape. Various graft sources and types were used for tip support in rhinoplasty such as columellar struts, septal extensions, and cap grafts.

The columellar strut graft, first introduced in 1932, has became a widely adopted technique. Typically a cartilage graft is positioned between the medial crura to provide support and stability to the nasal tip. Recent studies reported some drawbacks of columellar strut such as widening the columella and resorption or displacement of the graft due to their lack of attachment to the caudal septum. Septal extension grafts extend from the caudal edge of the nasal septum into the lower lateral cartilages, these grafts offer crucial structural support to the nasal tip. Despite of their the wide use of columellar strut and septal extention graft, limited studies compared their results.


Eligibility criteria: Inclusion Criteria:

1. Adult patient (more than 18 years).
2. Patients with any type of tip deformaties.
3. Patients fit for surgery.

Exclusion Criteria:

1. Patients with history of previous nasal surgery.
2. Pregnant patients.
3. Patients with chronic diseases affecting wound healing e.g. DM and blood diseases.

Primary outcomes:
measure: Tip projection and rotation
timeFrame: These values will be evaluated before surgical intervention and 6 months after the surgery
Secondary outcomes:
measure: Patient satisfaction
timeFrame: Before and 6 months after the surgery.
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02764775: Measuring Head Control Change With 2D Video Analysis After Utilization of Headpod in Children With Poor Head Control
Official title: Measuring Head Control Changes With 2d Video Analysis After Utilization of the Headpod in Children With Cerebral Palsy and Poor Head Control
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: To Determine Efficacy of the Headpod
Cerebral Palsy
Lead sponsor: Texas Woman's University
Sponsor class: OTHER
First posted: 2016-05-06
Enrollment: 14
Sex: ALL
Minimum age (years): 2
Maximum age (years): 14
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Quasi-experimental, one-way repeated measures design
Primary purpose: TREATMENT

Brief summary: Inclusion Criteria: children ages 2 to 14 years with poor head control and non progressive diagnoses. Exclusion criteria: significant change of status i.e. prolonged hospitalization, surgery; inability to tolerate using Headpod. Requires use of Headpod 3x per day for minimum of 15 minutes each time over a 6 month period. Log must be kept documenting usage of the Headpod. Video will be taken to document changes.

Detailed description: Requires usage of the Headpod 3x per day for a minimum of 15 minutes each time. Usage required for 6 month period. Log must be kept documenting usage of the Headpod. Video will be taken on initial trial use, 1 week post trial use, at 3 months post utilization of the Headpod and at 6 months post utilization of the Headpod.

Eligibility criteria: Inclusion Criteria:

* non progressive diagnoses with poor head control

Exclusion Criteria:

* recent prolonged hospitalization; surgery, inability to tolerate wearing the Headpod

Primary outcomes:
measure: Change in Head Holding Active Time From Baseline to 6 Months
timeFrame: baseline to 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Dallas
country: United States
facility: TWU School of Physical Therapy
state: Texas
Study officials:
affiliation: Texas Woman's University
name: Julie E Brown, DPT
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01516775: Gastric pH in Intubated Children
Official title: Untersuchung Des Magen-pH in Intubationsanästhesie Bei Kindern
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Preoperative Fasting
Keywords: preoperative care
preoperative period
fasting
Lead sponsor: University Children's Hospital, Zurich
Sponsor class: OTHER
First posted: 2012-01-25
Enrollment: 150
Sex: ALL
Minimum age (years): 1
Maximum age (years): 16
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: Fasting (according to ASA, ESA or institutional guidelines) is an important strategy to minimize the risk of regurgitation, vomiting and pulmonary aspiration during general anaesthesia; the effect of fasting time for clear fluid on gastric pH in children is goal of this study and can be investigated in children undergoing elective procedures in intubation anaesthesia without inconvenience or additional invasive procedure and hence without additional risk

Hypotheses: Gastric pH is higher in children that drink until 1 hour before anaesthesia induction than in those that drink until 2 hours before anaesthesia induction


Eligibility criteria: Inclusion Criteria:

* age \> 1 / \<= 16 years
* ASA class I or II
* elective surgery requiring general anaesthesia using tracheal intubation

Exclusion Criteria:

* disease or dysfunction of gastrointestinal tract
* chronic diseases or conditions not compatible with ASA class I or II

Primary outcomes:
measure: gastric pH
timeFrame: within 10 min after tracheal intubation
Secondary outcomes:
measure: subjective feeling of hunger/thirst
timeFrame: within 10 minutes after arrival of patient in operating theatre
measure: gastric aspirate volume
timeFrame: within 10 min after tracheal intubation
measure: Postoperative Nausea and Vomiting (PONV) in recovery unit
timeFrame: recovery period, on the average within 90 minutes after end of anaesthesia
measure: Behaviour during recovery period
timeFrame: recovery period, on the average within 90 minutes after end of anaesthesia
measure: Behaviour during anaesthesia induction
timeFrame: on the average within 20 minutes after arrival of patient in operating theatre
Other outcomes:
Locations:
city: Zurich
country: Switzerland
facility: University Children's Hospital
Study officials:
affiliation: University Children's Hospital, Zurich
name: Achim J Schmitz, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Schmidt AR, Buehler P, Seglias L, Stark T, Brotschi B, Renner T, Sabandal C, Klaghofer R, Weiss M, Schmitz A. Gastric pH and residual volume after 1 and 2 h fasting time for clear fluids in childrendagger. Br J Anaesth. 2015 Mar;114(3):477-82. doi: 10.1093/bja/aeu399. Epub 2014 Dec 13.
Clinical trial NCT05542875: Effects of Thrust Versus Non-Thrust Thoracic Manipulation on Mechanical Neck Pain.
Official title: Effects of Thrust Versus Non-Thrust Thoracic Manipulation on Mechanical Neck Pain.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Neck Pain
Lead sponsor: Foundation University Islamabad
Sponsor class: OTHER
First posted: 2022-09-16
Enrollment: 24
Sex: ALL
Minimum age (years): 18
Maximum age (years): 24
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomized Controlled Trial Study
Primary purpose: TREATMENT

Brief summary: Neck pain ranks as the 4th leading cause of disability, with high prevalence of mechanical neck pain in young population. As high as 30% of %. Individuals suffering from neck often report difficulty in performance of daily life, absence from work and decreased productivity. Several manual therapy treatment approaches are used for mechanical neck pain. The focus of this study is to compare the effectiveness of thrust and non-thrust thoracic manipulation for the treatment of mechanical neck pain in young population

Detailed description: craniovertebral angle, cervical range of motion and pain will be noted for each participant.

Eligibility criteria: Inclusion Criteria

* Both genders
* Age: 18-24 years
* Symptoms \<30 days
* FABQPA score \<12
* Increased upper thoracic spine kyphosis (visual estimate)
* CVA \< 48 Degrees

Exclusion Criteria

* Symptoms distal to shoulder
* Aggravation of symptoms with looking up
* Radiating lower back pain
* Neurological deficit
* Previous surgery
* Spondylolisthesis
* Spinal stenosis
* Inflammatory disease
* Vertebrobasilar artery insufficiency
* Pregnancy

Primary outcomes:
measure: Craniovertebral Angle
timeFrame: 8 days
Secondary outcomes:
measure: Cervical Range of Motion
timeFrame: 8 days
measure: Pain intensity
timeFrame: 8 days
Other outcomes:
Locations:
city: Rawalpindi
country: Pakistan
facility: Foundation University College of Physical Therapy
state: Punjab
Study officials:
References:
Clinical trial NCT01820975: Manipulation of Dietary Protein and the Anabolic Response
Official title: The Manipulation of Dietary Protein Intake on the Anabolic Response in Healthy Young Men
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Focus: Anabolic Response to Food Intake in Young Individuals
Condition Relevance: Skeletal Muscle Health, Sarcopenia
Keywords: Muscle protein synthesis
Dietary protein
Lead sponsor: Maastricht University Medical Center
Sponsor class: OTHER
First posted: 2013-03-29
Enrollment: 28
Sex: MALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: In the present study, the effect of habitual dietary protein on the anabolic response will be investigated.


Eligibility criteria: Inclusion Criteria:

* Males
* Aged between 18-35 years
* Healthy, recreationally active
* BMI \< 30 kg/m2

Exclusion Criteria:

* Smoking
* Allergies to milk proteins (whey or casein)
* Vegetarians
* Diagnosed GI tract diseases
* Female
* Arthritic conditions
* A history of neuromuscular problems
* Previous participation in amino acid tracer studies
* Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications

Primary outcomes:
measure: Muscle protein fractional synthetic rate following protein ingestion
timeFrame: 3 hours
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Maastricht University
name: Luc JC van Loon, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Gorissen SHM, Trommelen J, Kouw IWK, Holwerda AM, Pennings B, Groen BBL, Wall BT, Churchward-Venne TA, Horstman AMH, Koopman R, Burd NA, Fuchs CJ, Dirks ML, Res PT, Senden JMG, Steijns JMJM, de Groot LCPGM, Verdijk LB, van Loon LJC. Protein Type, Protein Dose, and Age Modulate Dietary Protein Digestion and Phenylalanine Absorption Kinetics and Plasma Phenylalanine Availability in Humans. J Nutr. 2020 Aug 1;150(8):2041-2050. doi: 10.1093/jn/nxaa024.
Clinical trial NCT03608475: Assessing a Limited Ultrasound Protocol in DDH
Official title: A Non-Inferiority Trial Assessing a Limited Ultrasound Protocol in the Treatment of Developmental Dysplasia of the Hip
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Developmental Dysplasia of the Hip
Lead sponsor: The Hospital for Sick Children
Sponsor class: OTHER
First posted: 2018-08-01
Enrollment: 100
Sex: ALL
Maximum age (years): 6
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Developmental Dysplasia of the Hip (DDH) is a common diagnosis in children that if untreated may lead to degeneration and arthritis of the hip joint at a young age. Ultrasound imaging is used to monitor progress of the developing hip joint during treatment. Initial data from our practice suggests that interim ultrasounds do not alter the course or outcome of treatment. Additionally, these ultrasounds add significant time to clinic visits and carry a substantial cost to the health care system. The goal of this study is to determine if limiting the number of ultrasounds during treatment results in the same outcomes while also evaluating the amount of time and money saved by omitting the ultrasounds.


Eligibility criteria: Inclusion Criteria:

* Aged 0-6 months at time of diagnosis
* Clinical and Ultrasound diagnosis of stable developmental dysplasia of the hip
* Children with dislocated/ unstable DDH will be included once the hip becomes stable
* Treated with Pavlik harness
* Assessed and treated at the SickKids Baby Hip Clinic

Exclusion Criteria:

* Underlying neuromuscular disease
* Teratologic hip dysplasia
* Prior treatment at other institutions
* Non-compliance with treatment protocol

Primary outcomes:
measure: Acetabular Index
timeFrame: When patient reaches 1 year of age
measure: International Hip Dysplasia Institute Score
timeFrame: When patient reaches 1 year of age
Secondary outcomes:
measure: Complication Rate
timeFrame: Through study completion, an average of two years
measure: Health Care Costs
timeFrame: Through study completion, an average of two years
measure: Hospital Appointment Duration
timeFrame: Through study completion, an average of two years
Other outcomes:
Locations:
city: Toronto
country: Canada
facility: The Hospital for Sick Children
state: Ontario
Study officials:
affiliation: The Hospital for Sick Children, Toronto, Ontario, Canada
name: Simon P Kelley, PhD, FRCS
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03372759: Tilt of the Intraocular Lens in Patients Undergoing Combined Phacoemulsification and Vitrectomy With Airtamponade
Official title: Tilt of the Intraocular Lens in Patients Undergoing Combined Phacoemulsification and Vitrectomy With Airtamponade
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Epiretinal Membrane
Lead sponsor: Vienna Institute for Research in Ocular Surgery
Sponsor class: OTHER
First posted: 2017-12-14
Enrollment: 42
Sex: ALL
Minimum age (years): 21
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Vitrectomy with membrane peeling has developed to be the gold-standard in treatment of epiretinal membranes. Due to the possibility of vitrectomy induced cataract, in many ophthalmic surgical centers it has become usual to indicate combined phacoemulsification and vitrectomy in case of existing cataract.

Epiretinal membranes (ERM) and pseudomaculaforamen are disorders involving the posterior pole of the eyeball with consecutive vision loss. ERM can be well visualized with spectral domain optical coherence tomography (SD-OCT). Different study groups showed that even intraoperative use of SD-OCT is possible.

Detailed description: The aim of the study is to document tilt of the intraocular lens in combined phacoemulsification and vitrectomy by photography of purkinjereflexes. During vitrectomy tamonade with air or saline are regarded as equal in substituting the removed vitreous. In case of airtamponade, air will be resolved within several days. As airtamponade induces more anterior movement of the implanted intraocular lens in the superior parts of the lens, tilt can result. Saline doesn´t have any influence on the intraocular lens.

Eligibility criteria: Inclusion Criteria:

* patients sheduled for combined phakoemulsification and 23G pars plana vitrectomy
* Minimum Age of 21 years
* written informed consent

Exclusion Criteria:

* none

Primary outcomes:
measure: postoperative tilt of the IOL is measured with purkinjemetry
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Vienna
country: Austria
facility: VIROS - Vienna Institute for Research in Ocular Surgers - Departement of Opthalmology - Hanusch Hospital
Study officials:
affiliation: Vienna Institute for Research in Ocular Surgery
name: Oliver Findl, Prof
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04358159: RCT Ventralex vs Onlay Mesh in Incisional Hernias
Official title: Randomised Controlled Trial of Ventralex Versus Onlay Mesh Repair for Midline Incisional Hernias
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Incisional Hernia of Midline of Abdomen
Lead sponsor: Karolinska Institutet
Sponsor class: OTHER
First posted: 2020-04-24
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomised controlled trial of Vantralex versus Progrip for repair of midline incisional hernias
Primary purpose: TREATMENT

Brief summary: A radomised controlled trial comparing Ventralex patch and Progrip mesh in surgery for midline incisional hernias

Detailed description: Incisional hernias in the midline is among the most common conditions requiring surgery. There are several factors which can increase the risk of incisional hernias, e.g. surgical technique, truncal obesity and other co-morbidities.

Repair with mesh-reinforcement is considered standard for the treatment of incisional hernias. Onlay and sublay mesh placements are the most commonly used methods. There are many different types of mesh available to use. Despite the widely use of composite ventral-patch Ventralex, there are few studies with small numbers of patients showing the advantage and disadvantage of ventral-patch. Some studies show that the onlay mesh-reinforcement remains a good alternative to the sublay mesh technique, while others showing fewer recurrences with the sublay mesh technique. The Ventralex mesh is usually placed on the peritoneum as a Intra peritoneum onlay mesh (IPOM). In this study intend to compare pre peritoneal Ventralex® mesh in sublay position with ProGrip self-fixating onlay mesh.

Eligibility criteria: Inclusion Criteria:

* Hernia defect 1-4 cm
* Incisional hernia or recurrent hernia after previous primary hernia repair
* BMI \<35
* Age 18-100 years

Exclusion Criteria:

* Defect size\>4 cm
* Ongoing pregnancy
* BMI\>35
* Primary hernia

Primary outcomes:
measure: Recurrence rate
timeFrame: One year
Secondary outcomes:
measure: Rate ofntra- and postoperative complications
timeFrame: 30 days
measure: Rate of seroma
timeFrame: one year
measure: Persisting postoperative pain
timeFrame: One year
measure: Sick leave
timeFrame: 30 days
Other outcomes:
Locations:
city: Karlskoga
country: Sweden
facility: Karlskoga Hospital
city: Karlskoga
country: Sweden
facility: Karlskoga Hospital
Study officials:
affiliation: Karolinska Institutet
name: Gabriel Sandblom, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01658059: Reducing Children's Anxiety Using Homeopathic Remedy Before Dental Treatment
Official title: Reducing Children's Anxiety Using Homeopathic Remedy Before Dental Treatment
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Children's Dental Anxiety
Lead sponsor: Hadassah Medical Organization
Sponsor class: OTHER
First posted: 2012-08-06
Enrollment: 22
Sex: ALL
Minimum age (years): 5
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: OTHER

Brief summary: Pharmacological interventions to aid behavior management's techniques are commonly used in pediatric dentistry. The aim of the medicaments is to control behavior and allow safe completion of a dental procedure. Homeopathic remedy is safe and can be effective to control behavior and decrease anxiety in children during dental treatment.

Aim: 1. To explore the efficacy of homeopathic drugs in decreasing children's dental anxiety before dental treatment.

2. To assess the effectiveness of homeopathic remedy in facilitating dental treatment for anxious children.

Methods: prospective, double-blind study. Thirty healthy children (5-12 years-old) will receive homeopathic remedy\\placebo before dental treatment. Anxiety reduction will be measured using: saliva cortisol levels, saliva α-amylase levels, facial image scale (FIS), and Houpt behavior scale.

Expected results: the homeopathic remedy will reduce anxiety and increase child cooperation during dental treatment.


Eligibility criteria: Inclusion Criteria:

* Dental anxiety
* Needs at least 2 dental treatment appointments

Exclusion Criteria:

* Medically compromised
* Cooperative, needs less than 2 dental treatment appointments

Primary outcomes:
measure: Reducing Children's Anxiety
timeFrame: Each dental apointment, aproximatly 30 minutes on the average
Secondary outcomes:
Other outcomes:
Locations:
city: Jerusalem
country: Israel
facility: Hadassah Medical Organization
Study officials:
References: