Clinical trial NCT03094377: Effect of Multisensory Stimulation on Upper Extremity Motor Recovery in Stroke Patient: a Preliminary Testing
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Stroke
Keywords: Multisensory stimulation; motor recovery
Lead sponsor: Tung Wah College
Sponsor class: OTHER
First posted: 2017-03-29
Enrollment: 12
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: This was a quasi-randomized-controlled pilot. Participants were randomly allocated by admission sequence to a multisensory therapy group or a conventional training group
Primary purpose: TREATMENT

Brief summary: Despite the advances in stroke rehabilitation, post-stroke upper extremity impairment is still a major challenge. Increasing evidence can be found supporting stimulation of the afferent receptor enhances neuroplasticity in the brain. Studies have suggested multisensory stimulation could promote motor learning by re-establishing the disrupted sensorimotor loop due to stroke and enhance neuroplasticity.

The objective of the study was to examine the effect of multisensory stimulation on upper-extremity motor recovery and self-care function in stroke patients.

Detailed description: Stroke patients referred to occupational therapy division of geriatric day hospital will be recruited and randomly assigned to a multisensory therapy group or a conventional training group. The Multisensory therapy group received 12 weeks (two sessions/ week; 90 minutes/session) training. Each session began with 15 minutes of sensory stimulation (cold and vibration), 45 minutes of motor training and 30 minutes of self-care training. The conventional training group included 12 weeks (two sessions/ week; 90 minutes/session) training. Each session included 60 minutes of upper extremity motor practice and 30 minutes of self-care training.

Outcome measures included: Brunnstrom's stage, Fugl-Meyer Assessment Scale and Functional Test for the Hemiplegic Upper Extremity were used for upper limb motor control and function; and Manual muscle testing was used for muscle strength. The modified Barthel Index was used for self-care performance

Eligibility criteria: Inclusion criteria:

* First-time ischemic or hemorrhagic stroke;
* Stroke onset \> 4 weeks and \< 6 months
* Single lesion
* Upper extremity motor deficit
* No severe cognitive impairment and able to follow verbal instructions.

Exclusion Criteria:

* Skin conditions/ injuries over the stimulation application areas
* Contraindication for cold or vibration application
* Speech disorder or global aphasia
* Musculoskeletal or cardiac disorders
* Other neurological conditions
* History of diabetes or sensory impairment attributable to peripheral vascular disease or neuropathy

Primary outcomes:
measure: Change from baseline Fugl-Meyer Assessment of Motor Recovery at 3 months
timeFrame: Baseline and post intervention at week 12
measure: Change from baseline Functional Test for the Hemiplegic Upper Extremity at 3 months
timeFrame: Baseline and post intervention at week 12
Secondary outcomes:
measure: Change from baseline Modified Barthel Index at 3 months
timeFrame: Baseline and post intervention at week 12
measure: Change from baseline Manual Muscle testing at 3 months
timeFrame: Baseline and post intervention at week 12
Other outcomes:
Locations:
city: Wong Tai Sin
country: Hong Kong
facility: Wong Tai Sin Hospital
Study officials:
affiliation: Occupational Therapist
name: Ray Li, Master
role: PRINCIPAL_INVESTIGATOR
References: