louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04043559: Cortical Cerebellar Infarctions Associated With Patent Foramen Ovale in Young Stroke Patients
Official title: Small Cortical Cerebellar Infarctions Are Associated With Patent Foramen Ovale in Young Cryptogenic Stroke Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Brain Infarction
Lead sponsor: Centre Hospitalier Universitaire de Nīmes
Sponsor class: OTHER
First posted: 2019-08-02
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Consecutive young (\<60 years) cryptogenic stroke patients with PFO recruited between January 2016 and May 2019 in our center, and compared these patients with sex- and age-matched controls with cryptogenic stroke without PFO.

Brief summary: The investigator retrospectively analyzed consecutive young (\<60 years) cryptogenic stroke patients with Patient Foramen Ovale (PFO) recruited between January 2016 and May 2019 in our center, and compared these patients with sex- and age-matched controls with cryptogenic stroke without PFO. Analyzed baseline characteristics: sex, age, cardiovascular risk factors, history of stroke, and cortical/subcortical localization, arterial territory, number of lesions, and lesion size of the acute symptomatic infarction, together with the ROPE score. The presence and the number of acute and chronic SCCI lesions were assessed.


Eligibility criteria: Inclusion Criteria:

* patients : young (\<60 years) adult patients,
* Patient recruited and registered in our stroke database between January 2016 and May 2016 of our center (Nîmes University Hospital, France),
* Patients presenting with an acute symptomatic infarction (confirmed by diffusion-weighted MRI) of unknown origin
* Controls : age-matched controls with cryptogenic stroke without PFO

Primary outcomes:
measure: number of infarction lesions
timeFrame: day 1
measure: infarction location
timeFrame: day 1
measure: size of subcortical lesion
timeFrame: day 1
measure: presence of multiterritorial infarction
timeFrame: day 1
Secondary outcomes:
Other outcomes:
Locations:
city: Nîmes
country: France
facility: CHU Nîmes
Study officials:
References:
citation: Renard D, Ion I, Ricci JE, Mura T, Thouvenot E, Wacongne A. Chronic Small Cortical Cerebellar Infarctions on MRI are Associated with Patent Foramen Ovale in Young Cryptogenic Stroke. Cerebrovasc Dis. 2020;49(1):105-109. doi: 10.1159/000505959. Epub 2020 Feb 14.
Clinical trial NCT03385759: Trial of Unicompartmental Versus Total Knee Arthroplasty
Official title: A Prospective Randomized Trial of Unicompartmental Versus Total Knee Arthroplasty for the Treatment of Medial Compartment Osteoarthritis
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Osteo Arthritis Knee
Keywords: unicompartmental knee
total knee arthroplasty
osteoarthritis
Lead sponsor: Anderson Orthopaedic Research Institute
Sponsor class: OTHER
Collaborators: name: Rush University Medical Center
First posted: 2017-12-28
Enrollment: 112
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study is a prospective, randomized trial to compare patient outcomes of unicompartmental knee arthroplasty (UKA) and total knee arthroplasty (TKA) for the treatment of medial compartment osteoarthritis.


Eligibility criteria: Inclusion Criteria:

* medial compartment osteoarthritis of the knee
* knee flexion greater than greater than 90 degrees
* flexion contracture of less than 10 degrees
* varus deformity \< 20 degrees
* grade IV degeneration of the medial compartment

Exclusion Criteria:

* lateral compartment degenerative changes
* previous lateral meniscectomy
* anterior cruciate ligament deficiency
* body mass index \> 40
* inflammatory arthritis
* history of septic arthritis
* hemoglobin A1c \> 8.0
* chronic liver disease
* stage 3A or greater chronic renal disease
* active IV drug abuse
* patients requiring thromboembolic prophylaxis

Primary outcomes:
measure: Knee Society Score
timeFrame: 1 year
measure: Knee Society Score
timeFrame: 2 years
Secondary outcomes:
measure: Revision
timeFrame: 2 years
Other outcomes:
Locations:
city: Chicago
country: United States
facility: Rush University Medical Center
state: Illinois
city: Alexandria
country: United States
facility: Anderson Orthopaedic Research Institute
state: Virginia
Study officials:
affiliation: Anderson Orthopaedic Institute
name: Kevin Fricka, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05789459: Comparison of Outcomes With Stapler Versus Hand-Sewn Closure After Minimally Invasive Distal Pancreatectomy
Official title: Comparison of Outcomes With Stapler Versus Hand-Sewn Closure of the Pancreatic Stump Following Minimally Invasive Distal Pancreatectomy: A Retrospective Cohort Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Distal Pancreatectomy
Postoperative Pancreatic Fistula
Lead sponsor: Zhejiang University
Sponsor class: OTHER
First posted: 2023-03-29
Enrollment: 384
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who underwent MDP in our institution between July 2018 and June 2021.

Brief summary: The incidence of postoperative pancreatic fistula (POPF) after Distal pancreatectomy (DP) remains high. Of the available mitigation strategies, high-quality closure of the pancreatic stump is fundamental.

Researchers failed to find a decrease in the incidence of POPF after stapler closure of the pancreatic stump compared with that related to hand-sewn suture in DP. Minimally invasive DP (MDP) is becoming the first choice for patients and surgeons, few studies have evaluated whether stapler closure is superior to hand-sewn suture for stump closure in MDP.

Therefore, this retrospective study was aimed at evaluating the effect of stapler versus hand-sewn closure on the incidence of POPF after MDP.


Eligibility criteria: Inclusion Criteria:

* Underwent elective minimally invasive pancreatic body and tail resection with or without splenectomy

Exclusion Criteria:

* Incomplete medical records
* History of previous pancreatic operations
* Emergent operation
* Conversion to open pancreatectomy
* Receipt of wedge resection or other procedures

Primary outcomes:
measure: Postoperative pancreatic fistula (POPF)
timeFrame: Within 3 months after pancreatic surgery
Secondary outcomes:
measure: delayed gastric emptying (DGE)
timeFrame: Within 3 months after pancreatic surgery
measure: postpancreatectomy hemorrhage (PPH)
timeFrame: Within 3 months after pancreatic surgery
measure: Chyle leak
timeFrame: Within 3 months after pancreatic surgery
measure: Surgical complications
timeFrame: Within 3 months after pancreatic surgery
Other outcomes:
Locations:
city: Hangzhou
country: China
facility: the First Affiliated Hospital, School of Medicine, Zhejiang University
state: Zhejiang
Study officials:
affiliation: Zhejiang University
name: Tingbo Liang
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02493959: Degradation of the Anorexic Hormone Peptide YY
Official title: Degradation of the Anorexic Hormone Peptide YY
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: EARLY_PHASE1
Conditions: Healthy
Keywords: PYY
Degradation
kinetics
men
Lead sponsor: Hvidovre University Hospital
Sponsor class: OTHER
Collaborators: name: University of Copenhagen
First posted: 2015-07-10
Enrollment: 8
Sex: MALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: Peptide YY (PYY) is a gastrointestinal hormone released from the enteroendocrine cell upon food intake. The N-terminal truncated form, PYY3-36, exerts anorexic effects. In this study we want to investigate the kinetics of PYY1-36 and PYY3-36 and to examine whether a C-terminally degraded metabolite, PYY3-34, is formed after infusion of PYY.


Eligibility criteria: Inclusion Criteria:

* Healthy
* Normal BMI (18.5-25kg/m2)

Exclusion Criteria:

* Diabetes Mellitus
* Gastric bypass
* Non-caucasian
* Height changes \>3 kg within last two months
* Hemoglobin \< 7.6 mmol/l
* Chronic disease
* Smoking
* Regularly use of medicine
* Drug abuse

Primary outcomes:
measure: PYY3-34 concentration
timeFrame: 0-240 min
measure: Half-lives of PYY1-36 and PYY3-36
timeFrame: 0-240 min
Secondary outcomes:
Other outcomes:
measure: Appetite and nausea scores
timeFrame: 0-240 min
measure: Blood pressure
timeFrame: 0-240 min
measure: Blood glucose
timeFrame: 0-240 min
measure: Heart rate
timeFrame: 0-240 min
Locations:
city: Hvidovre
country: Denmark
facility: Department of Endocrinology, Hvidovre Hospital
Study officials:
References:
Clinical trial NCT05244759: Mass Balance Recovery, Absorption, Metabolism and Excretion of [14C]-BLU-5937
Official title: A Single Dose Study to Assess the Mass Balance Recovery, Absorption, Metabolism and Excretion of [14C]-BLU-5937 in Healthy Male Subjects After Oral Dosing
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Healthy
Lead sponsor: Bellus Health Inc. - a GSK company
Sponsor class: INDUSTRY
First posted: 2022-02-17
Enrollment: 6
Sex: MALE
Minimum age (years): 30
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This is a single-centre, open-label, non-randomised, single-period, single-dose study in healthy male subjects designed to assess the mass balance recovery, PK, metabolite profile and metabolite identification of \[14C\]-BLU-5937.


Eligibility criteria: Inclusion Criteria:

* Healthy males

Exclusion Criteria:

* History of clinically significant cardiovascular, renal, hepatic, chronic respiratory or gastrointestinal disease, neurological or psychiatric disorder,as judged by the investigator

Primary outcomes:
measure: Mass balance recovery of total radioactivity in all excreta after a single oral dose of [14C]-BLU-5937
timeFrame: 168 hour
Secondary outcomes:
Other outcomes:
Locations:
city: Nottingham
country: United Kingdom
facility: Quotient Sciences
state: Ruddington
Study officials:
References:
Clinical trial NCT04848259: Effect of Honey and Dexamethason on Extraction Healing
Official title: A Novel Therapeutic Approach for Controlling Complications Associated With Impacted Mandibular Third Molar Removal
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: EARLY_PHASE1
Conditions: Impacted Third Molar Tooth
Lead sponsor: Al-Azhar University
Sponsor class: OTHER
First posted: 2021-04-19
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Natural honey and dexamethason will be given before impaction removal then postoperative complications will be evaluated

Detailed description: Patient with impacted lower third molar will be selected to this study agording to agent applied preoperative. Group 1 will receive topical honey and Group 2 will receive IV dexamethason. After surgical removal of impacted tooth under local anesthesia postoperative pain mouth opening, and swelling will be evaluated

Eligibility criteria: Inclusion Criteria:

* impacted 3rd molar
* healthy patient No smoking

Exclusion Criteria:

* history of smoking Medical disease

Primary outcomes:
measure: Interincisal distance
timeFrame: Preoperative
measure: Interincisal distance
timeFrame: I day postoperative
measure: Interincisal distance
timeFrame: 3rd day postoperative
measure: Interincisal distance
timeFrame: 7th day postoperative
measure: Edema
timeFrame: Preoperative
measure: Edema
timeFrame: 1day postoperative
measure: Edema
timeFrame: 2nd day postoperative
measure: Edema
timeFrame: 3rd day postoperative
measure: Edema
timeFrame: 7th day postoperative
Secondary outcomes:
Other outcomes:
Locations:
city: Jeddah
country: Saudi Arabia
facility: Vision colleges
Study officials:
References:
Clinical trial NCT00766259: Relationship of Staphylococcal Colonization to Infection
Official title: Relationship of Staphylococcal Colonization to Infection
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: MRSA Infection
Keywords: methicillin-resistant Staphylococcus
colonization
Lead sponsor: Veterans BioMedical Research Institute
Sponsor class: OTHER
First posted: 2008-10-03
Enrollment: 0
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: all patients admited

Brief summary: Inpatients will be prospectively have nares screened and MRSA strains collected. All clinical MRSA strains of patients will also be prospectively collected. A sensitive strain discrimination test of spa typing will be used to determine if the strains are related. Hypotheses are

1. Strain colonization durations vary and may be very short in days to weeks.
2. Colonizing strains rarely infect 3) Both 1 and 2 may be affected by the patient's co-morbidity.

Detailed description: Patients of special interest:

1. Skin and soft tissue infection
2. Nursing home patients
3. Vascular patients with leg lesions
4. ICU patients
5. Hemodialysis patients
6. Outpatients without history of infections(controls) will have nares screened for MRSA and then monthly for 1 year.

All strains will be saved and spa typed. Analysis of the data will be performed to answer the questions and hypotheses and to answer is the screening effort and the isolation of patients for MRSA as is in current practice worthwhile and is there any scientific data to support this practice

Eligibility criteria: Inclusion Criteria:

* Admitted and one of the co-morbid groups
* Ambulatory care patient with no infections

Exclusion Criteria:

* All others

Primary outcomes:
measure: Percent of infection strains which were also colonizer earlier
timeFrame: 3 years
Secondary outcomes:
measure: Duration of strain colonization among co-morbidity cohorts
timeFrame: 3 years
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT06098859: Thoracic Epidural Analgesia and Bilateral Erector Spinae Plane Block on Postoperative Pain in Open Heart Surgeries
Official title: Comparison of the Effects of Thoracic Epidural Analgesia and Bilateral Erector Spinae Plane Block on Postoperative Pain and Respiratory Fonctions in Open Heart Surgeries''
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pain, Postoperative
Respiratory Complication
Keywords: Thoracic epidural analgesia
erector spinae plane block
heart surgery
Lead sponsor: Karadeniz Technical University
Sponsor class: OTHER
First posted: 2023-10-25
Enrollment: 93
Sex: ALL
Minimum age (years): 20
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: The effects of thoracic epidural analgesia and erector spinae plane block on postoperative pain were compared with the control group.
Primary purpose: PREVENTION

Brief summary: Postoperative pain negatively effects respiratory functions in open heart surgeries. The aim of the study is to compare the effects of thoracic epidural analgesia (TEA) and erector spinae plane block (ESPB) on postoperative pain and respiratory functions in patients undergoing open heart surgery with sternotomy

Detailed description: Thoracic epidural catheter was inserted to patients in Group T at the T4-T5 vertebra level before induction of general anesthesia. And then local anesthetic infusion was started until postoperative 48. hours.

Bilateral erector spinae plan block was applied with total 40 ml of local anesthetic solution to patients in Group E at the T4-T5 vertebra level before induction of general anesthesia.

The control group was infused with 1 mcg/kg/min fentanyl during the surgery. In the postoperative period, 1 g paracetamol was infused 4 times a day.

All patients underwent general anesthesia with the same method and medications.

Tramadol/diclofenac was administered to patients with a pain score (NRS) above 4. NRS and tidal volumes (TV) of the patients were measured at 0, 2, 6, 12, 24, 36 and 48. hours after extubation. Postoperative mechanical ventilation durations, intensive care unit and hospital stays, additional analgesic needs and respiratory complications of the patients were recorded.

Eligibility criteria: Inclusion Criteria:

* Has ASA II-IV score
* Having open heart surgery

Exclusion Criteria:

* Having a psychiatric illness
* Using analgesic medication due to chronic pain
* Uncooperative

Primary outcomes:
measure: Postoperative pain
timeFrame: Postoperative 48 hours
measure: Respiratory functions
timeFrame: Postoperative 48 hours
Secondary outcomes:
measure: Analgesic requirement. When the VRS was more than 4 points
timeFrame: Postoperative 48 hours
measure: Intensive care and hospital stay
timeFrame: postoperative 30 days
Other outcomes:
Locations:
city: Ortahisar
country: Turkey
facility: Engin Ertürk
state: Trabzon
Study officials:
affiliation: Karadeniz Technical University, Medical Faculty, Anesthesiology and Intensive Care
name: Engin Ertürk, Prof. Dr
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00740259: Efficacy and Tolerability of Flunarizine for the Treatment of Schizophrenia: Comparison With Haloperidol
Official title: Is Flunarizine a Cheap, Well-Tolerated and Long-Acting Atypical Antipsychotic? A Randomized Double-Blind Flexible-Dose Clinical Trial Versus Haloperidol for the Treatment of Schizophrenia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Schizophrenia
Keywords: flunarizine
schizophrenia
antipsychotic
Lead sponsor: Ambulatório de Bipolaridade
Sponsor class: OTHER
Collaborators: name: Stanley Medical Research Institute
First posted: 2008-08-22
Enrollment: 70
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Flunarizine is a calcium channel blocker traditionally used for the treatment of vertigo and migraine. It also has the mechanism of action associated with antipsychotic activity (D2 receptor blockade), but has never been tested as such. The investigators hypothesis is that flunarizine can be an atypical antipsychotic.

Detailed description: The main advantage of flunarizine over other D2 receptor blockers is its long half-life, so that it may be administered weekly or may delay relapse if medication is interrupted.

Eligibility criteria: Inclusion Criteria:

* DSM-IV schizophrenic or schizoaffective patients between 18 and 55 years old with a PANSS score above 45.

Exclusion Criteria:

* Clinical disease
* Pregnancy
* Drug dependence (except for nicotine) in the past month and history of being refractory to at least 2 antipsychotics taken appropriately.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: São Paulo
country: Brazil
facility: Universidade Federal de São Paulo
state: SP
Study officials:
References:
citation: Bisol LW, Brunstein MG, Ottoni GL, Ramos FL, Borba DL, Daltio CS, de Oliveira RV, Paz GE, de Souza SE, Bressan RA, Lara DR. Is flunarizine a long-acting oral atypical antipsychotic? A randomized clinical trial versus haloperidol for the treatment of schizophrenia. J Clin Psychiatry. 2008 Oct;69(10):1572-9. doi: 10.4088/jcp.v69n1007. Epub 2008 Sep 1.
Clinical trial NCT02830659: Cochlear Implants Registry in Thailand Project
Official title: Cochlear Implants Registry in Thailand Project
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Cochlear Implantation
Lead sponsor: Khon Kaen University
Sponsor class: OTHER
Collaborators: name: Ministry of Health, Thailand
First posted: 2016-07-13
Enrollment: 1500
Sex: ALL
Minimum age (years): 1
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patient who underwent surgery for cochlear implant

Brief summary: The purpose of this study is to determine the outcome of cochlear implant including post operative hearing ability, developing of language, complication from cochlear implant, quality of life, and success factor of cochlear implant.


Eligibility criteria: Inclusion Criteria:

* Patients who underwent surgery with cochlear implant

Exclusion Criteria:

* Patients who reject to participate with this project

Primary outcomes:
measure: Aids Threshold 1
timeFrame: 1 year
Secondary outcomes:
measure: CAP 1
timeFrame: 1 year
measure: Quality of life
timeFrame: 5 years
Other outcomes:
Locations:
city: Bangkok
country: Thailand
facility: King Bhumibol Adulyadej Hospital
city: Bangkok
country: Thailand
facility: King Chulalongkorn Memorial Hospital
city: Bangkok
country: Thailand
facility: Department of Otolaryngology Phramongkutklao College of Medicine
city: Bangkok
country: Thailand
facility: Rajavithi Hospital
city: Bangkok
country: Thailand
facility: Ramathibodi Hospital
city: Bangkok
country: Thailand
facility: Siriraj Hospital
city: Bangkok
country: Thailand
facility: Department of Otolaryngology, Srinakharinwirot University
city: Chiang Mai
country: Thailand
facility: Department of Otolaryngology, Faculty of Medicine, Chiang Mai University
city: Khon Kaen
country: Thailand
facility: Srinagarind Hospital
city: Songkhla
country: Thailand
facility: Songkhlanagarind Hospital
city: Trang
country: Thailand
facility: Trang Hospital
Study officials:
References:
Clinical trial NCT03038659: Role of Intima-media Thickness in Determining Arteriogenic Erectile Dysfunction
Official title: Predictive Value of Measuring Intima-media Thickness of Cavernosal Artery in Diagnosis of Arteriogenic Erectile Dysfunction by Penile Duplex
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Erectile Dysfunction
Lead sponsor: Adam International Hospital
Sponsor class: OTHER
First posted: 2017-02-01
Enrollment: 70
Sex: MALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Erectile dysfunction pateints

Brief summary: Erectile dysfunction.

Detailed description: The intima media thickness is increasingly used as a surrogate end point of vascular outcomes in clinical trials aimed at determining the success of interventions that lower risk factors for atherosclerosis and associated diseases (stroke, myocardial infarction and peripheral artery diseases, like disease of cavernosal artery). The investigators hypothesized that the IMT of cavernosal artery would add to the predictive value of vasculogenic erectile dysfunction risk and outcomes. This study seeks to evaluate these hypotheses with our experience, investigating the predictive accuracy of Cavernosal Doppler ultrasound findings for discriminating patients with vasculogenic erectile dysfunction.

Eligibility criteria: Inclusion Criteria:

* Erectile dysfunction patients

Exclusion Criteria:

* Penile trauma.

Primary outcomes:
measure: erectile dysfunction
timeFrame: six months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References: