Clinical trial NCT06793345: Walking Training Improves Thyroid and Cardiometabolic Markers in Postmenopausal Obesity
Official title: Moderate Intensity Intermittent Walking Training (MIWT) Improves Thyroid Function and Cardiometabolic Risk Factors in Obese Postmenopausal Women
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Thyroid Hormones
Cardiometabolic Risk Factors
Keywords: Thyroid hormones
Lipid profile
Obesity
Blood pressure
Moderate intensity intermittent walking training
Body composition
Lead sponsor: High Institute of Sports and Physical Education of Kef
Sponsor class: OTHER
First posted: 2025-01-27
Enrollment: 36
Sex: FEMALE
Minimum age (years): 50
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The goal of this clinical trial is to investigate the impact of a 10-week MIWT program on thyroid hormone levels and key cardiometabolic markers in obese postmenopausal women. The main question it aims to answer is:

Does MIWT enhance thyroid function and reduce cardiometabolic risk factors in this population? Researchers will compare MIWT (designed to MIWT group) to non-training intervention (designed to control group) to see if the training program works to improve thyroid function and cardiometabolic risk factors.

Participants in MIWT group will: perform a 10-week MIWT program, four sessions per week (5 repetitions of 6-min-walking-test (6MWT) at 60-80% of 6MWTdistance measured at baseline, interspersed by 6-min of active recovery between repetitions).

Participants in control group will : not perform any physical training and maintain their usual daily activities.

Detailed description: This study aimed to investigate the impact of a 10-week MIWT program on thyroid hormone levels and key cardiometabolic markers in obese postmenopausal women. Thirty-six obese postmenopausal women (BMI≥30 kg.m-2, aged 50-60 yrs.) were randomized to either a moderate-intensity intermittent walking training (MIWT) group (n=18) or control group (CG, n=18). Participants performed a 10-week MIWT program, four sessions per week (5 repetitions of 6-min-walking-test (6MWT) at 60-80% of 6MWTdistance measured at baseline, interspersed by 6-min of active recovery between repetitions). Body composition, thyroid hormones (thyroid stimulating hormone (TSH) and thyroxine free (FT4)), lipid profile (triglycerides (TRG), total cholesterol(TC), high-density lipoprotein cholesterol(HDLC) and low-density lipoprotein cholesterol(LDLC)), blood pressure (systolic and diastolic blood pressure) and aerobic fitness (6MWT) were determined before and after the MIWT.

Eligibility criteria: Inclusion Criteria:

* Body mass index≥ 30 kg.m-2.
* Age between 50 and 60.
* Amenorrhea for \>12 months.
* Stable eating habits.

Exclusion Criteria:

* Chronic diseases.
* Medical contraindications to physical activity.
* Hormone replacement therapy.

Primary outcomes:
measure: Thyroid hormones
timeFrame: At baseline and after ten weeks of MIWT.
measure: Body composition
timeFrame: At baseline and after ten weeks of MIWT.
measure: Lipid profile
timeFrame: At baseline and after ten weeks of MIWT.
Secondary outcomes:
measure: Systolic and diastolic blood pressure
timeFrame: At baseline and after ten weeks of MIWT.
measure: Heart rate
timeFrame: At baseline and after ten weeks of MIWT
measure: 6 min walking test distance
timeFrame: At baseline and after ten weeks of MIWT
measure: Perceived exertion rating
timeFrame: At baseline and after ten weeks of MIWT.
Other outcomes:
Locations:
city: Boulifa
country: Tunisia
facility: High Institute of Sports and Physical Education of Kef
state: Kef
Study officials:
References: