Clinical trial NCT05093933: A Study of Vericiguat (MK-1242) in Participants With Chronic Heart Failure With Reduced Ejection Fraction (HFrEF) (MK-1242-035)
Official title: A Pivotal Phase 3 Randomized, Placebo-controlled Clinical Study to Evaluate the Efficacy and Safety of the sGC Stimulator Vericiguat/MK-1242 in Adults With Chronic Heart Failure With Reduced Ejection Fraction
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Chronic Heart Failure With Reduced Ejection Fraction
Lead sponsor: Merck Sharp & Dohme LLC
Sponsor class: INDUSTRY
First posted: 2021-10-26
Enrollment: 6105
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the efficacy and safety of vericiguat in participants with chronic heart failure with reduced ejection fraction (HFrEF), specifically those with symptomatic chronic HFrEF who have not had a recent hospitalization for heart failure or need for outpatient intravenous (IV) diuretics. The primary hypothesis is that vericiguat is superior to placebo in reducing the risk of cardiovascular death or heart failure hospitalization.


Eligibility criteria: Inclusion Criteria:

* History of chronic HF \[New York Heart Association (NYHA) Class II to IV\] on guideline-directed medical therapy for heart failure (GDMT) with no HF hospitalization within 6 months or outpatient IV diuretic use within 3 months before randomization.
* Left ventricular ejection fraction (LVEF) of ≤40%, assessed within 12 months before randomization by any imaging method.
* Elevated N-terminal pro-brain natriuretic peptide (NT-proBNP) levels.
* A female participant is eligible to participate if she is not pregnant or breastfeeding, is not a woman of childbearing potential (WOCBP), or is a WOCBP and agrees to follow contraceptive guidance during the study intervention period and for at least 1 month after the last dose of study intervention.

Exclusion Criteria:

* Has SBP \<100 mm Hg or symptomatic hypotension.
* Awaiting heart transplantation, is receiving continuous IV infusion of an inotrope, or has or anticipates receiving an implanted ventricular assist device.
* Amyloidosis or sarcoidosis.
* Primary valvular heart disease requiring surgical procedure or intervention or has undergone a valvular surgical procedure or intervention within 3 months before randomization.
* Hypertrophic cardiomyopathy.
* Acute myocarditis or Takotsubo cardiomyopathy.
* History of heart transplant.
* Tachycardia-induced cardiomyopathy and/or uncontrolled tachyarrhythmia.
* Acute coronary syndrome, or undergone coronary artery bypass grafting (CABG) or percutaneous coronary intervention (PCI) within 3 months before randomization.
* History of symptomatic carotid stenosis, transient ischemic attack (TIA), or stroke within 3 months before randomization.
* Malignancy or other noncardiac condition limiting life expectancy to \<3 years.
* Requires continuous home oxygen for severe pulmonary disease.
* Interstitial lung disease.
* Discontinuation or dose modification of GDMT or vericiguat within 4 weeks before randomization.
* Recent history (within the last year) of drug or alcohol abuse or dependence.

Primary outcomes:
measure: Time to First Occurrence of Composite Endpoint of Cardiovascular (CV) Death or Heart Failure (HF) Hospitalization
timeFrame: From date of randomization until the date of first occurrence of a CV death or HF hospitalization, assessed up to approximately 40 months
Secondary outcomes:
measure: Time to First Occurrence of CV Death
timeFrame: From date of randomization until the date of first occurrence of a CV death, assessed up to approximately 40 months
measure: Time to First Occurrence of HF Hospitalization
timeFrame: From date of randomization until the date of first occurrence of a HF hospitalization, assessed up to approximately 40 months
measure: Time to Total HF Hospitalizations (Including First and Recurrent Events)
timeFrame: Up to approximately 40 months
measure: Time to First Occurrence of Composite Endpoint of All-Cause Mortality or HF Hospitalization
timeFrame: From date of randomization until the date of first occurrence of death or HF hospitalization, assessed up to approximately 40 months
measure: Time to All-Cause Mortality
timeFrame: From date of randomization until the date of death, assessed up to approximately 40 months
measure: Percentage of Participants who Experienced One or More Selected Nonserious Adverse Events (NSAEs)
timeFrame: Up to approximately 40 months
measure: Percentage of Participants Who Experienced One or More Serious Adverse Events (SAEs)
timeFrame: Up to approximately 40 months
measure: Percentage of Participants Who Experienced One or More Events of Clinical Interest (ECIs)
timeFrame: Up to approximately 40 months
Other outcomes:
Locations:
city: Alexander City
country: United States
facility: Advanced Cardiovascular - Alexander City ( Site 0038)
state: Alabama
city: Birmingham
country: United States
facility: University of Alabama at Birmingham - School of Medicine-Cardiology ( Site 0153)
state: Alabama
city: Huntsville
country: United States
facility: Heart Center Research, LLC ( Site 0156)
state: Alabama
city: Gilbert
country: United States
facility: Mercy Gilbert Medical Center-Dignity Health Cardiology ( Site 0075)
state: Arizona
city: Covina
country: United States
facility: Valley Clinical Trials, Inc. ( Site 0085)
state: California
city: Los Angeles
country: United States
facility: VA West Los Angeles Medical Center-Cardiology ( Site 0149)
state: California
city: Northridge
country: United States
facility: Valley Clinical Trials Inc ( Site 0006)
state: California
city: Torrance
country: United States
facility: Lundquist Institute for Biomedical Innovation at Harbor-UCLA Medical Center ( Site 0010)
state: California
city: Vista
country: United States
facility: Blue Coast Research Center ( Site 0053)
state: California
city: Boca Raton
country: United States
facility: Excel Medical Clinical Trials ( Site 0008)
state: Florida
city: Doral
country: United States
facility: Universal Axon Clinical Research, LLC ( Site 0022)
state: Florida
city: Fort Lauderdale
country: United States
facility: Holy Cross Hospital ( Site 0100)
state: Florida
city: Hialeah
country: United States
facility: Indago Research and Health Center Inc ( Site 0011)
state: Florida
city: Hollywood
country: United States
facility: South Florida Research Solutions ( Site 0058)
state: Florida
city: Jacksonville
country: United States
facility: University of Florida - Jacksonville ( Site 0169)
state: Florida
city: Jacksonville
country: United States
facility: East Coast Institute for Research, LLC ( Site 0047)
state: Florida
city: Miami
country: United States
facility: Cardiovascular Research Center of South Florida ( Site 0074)
state: Florida
city: Miami
country: United States
facility: ProLive Medical Research ( Site 0032)
state: Florida
city: Port Charlotte
country: United States
facility: Peace River Cardiovascular Center ( Site 0088)
state: Florida
city: Safety Harbor
country: United States
facility: BAYCARE MEDICAL GROUP ( Site 0099)
state: Florida
city: Saint Augustine
country: United States
facility: East Coast Institute for Research - St. Augustine ( Site 0016)
state: Florida
city: Sarasota
country: United States
facility: Cardiovascular Center of Sarasota ( Site 0154)
state: Florida
city: Atlanta
country: United States
facility: Emory University School of Medicine ( Site 0123)
state: Georgia
city: Columbus
country: United States
facility: IACT Health ( Site 0106)
state: Georgia
city: Johns Creek
country: United States
facility: NSC Research ( Site 0068)
state: Georgia
city: Macon
country: United States
facility: Georgia Arrhythmia Consultants and Research Institute ( Site 0042)
state: Georgia
city: Thomasville
country: United States
facility: Cardiovascular Consultants of South Georgia, LLC ( Site 0137)
state: Georgia
city: Chicago
country: United States
facility: Mount Sinai Hospital ( Site 0050)
state: Illinois
city: Hazel Crest
country: United States
facility: Chicago Medical Research ( Site 0086)
state: Illinois
city: Peoria
country: United States
facility: OSF Healthcare Cardiovascular Institute ( Site 0122)
state: Illinois
city: Peoria
country: United States
facility: Methodist Medical Center of Illinois ( Site 0098)
state: Illinois
city: Indianapolis
country: United States
facility: Franciscan Physician Network - Indiana Heart Physicians ( Site 0087)
state: Indiana
city: Merrillville
country: United States
facility: The Heart Center of Lake County Research Institute-Research ( Site 0147)
state: Indiana
city: Munster
country: United States
facility: Cardiovascular Research of Northwest Indiana ( Site 0036)
state: Indiana
city: Richmond
country: United States
facility: Reid Physician Associates ( Site 0054)
state: Indiana
city: Iowa City
country: United States
facility: University of Iowa ( Site 0005)
state: Iowa
city: Wichita
country: United States
facility: Alliance for Multispecialty Research, LLC ( Site 0143)
state: Kansas
city: Louisville
country: United States
facility: Norton Healthcare-Norton Heart Specialist ( Site 0062)
state: Kentucky
city: Alexandria
country: United States
facility: Cambridge Medical Trials ( Site 0041)
state: Louisiana
city: Hammond
country: United States
facility: Louisiana Heart Center - Hammond ( Site 0004)
state: Louisiana
city: Hammond
country: United States
facility: The Heart Clinic - Hammond ( Site 0155)
state: Louisiana
city: Houma
country: United States
facility: Cardiovascular Institute of the South ( Site 0072)
state: Louisiana
city: Lafayette
country: United States
facility: Cardiovascular Institute of the South, 3 ( Site 0096)
state: Louisiana
city: Monroe
country: United States
facility: IMA Clinical Research ( Site 0112)
state: Louisiana
city: Opelousas
country: United States
facility: Cardiovascular Institute of the South ( Site 0081)
state: Louisiana
city: Baltimore
country: United States
facility: Maryland Cardiovascular Specialists ( Site 0056)
state: Maryland
city: Lanham
country: United States
facility: Capitol Cardiology Associates - Lanham Office-Maryland Research Centers ( Site 0167)
state: Maryland
city: Southfield
country: United States
facility: Ascension Providence Hospital ( Site 0094)
state: Michigan
city: Jackson
country: United States
facility: Phillips Medical Services ( Site 0070)
state: Mississippi
city: Jackson
country: United States
facility: The University of Mississippi Medical Center-Cardiovascular ( Site 0073)
state: Mississippi
city: Columbia
country: United States
facility: University of Missouri Hospital ( Site 0163)
state: Missouri
city: Saint Louis
country: United States
facility: Washington University-Department of Medicine ( Site 0044)
state: Missouri
city: Saint Louis
country: United States
facility: St. Louis Heart and Vascular, P.C.-Clinical Trials Unit ( Site 0029)
state: Missouri
city: Kalispell
country: United States
facility: Logan Health Research ( Site 0017)
state: Montana
city: Reno
country: United States
facility: Renown Regional Medical Center-Renown Institute for Heart and Vascular Health ( Site 0168)
state: Nevada
city: Raritan
country: United States
facility: Amici Clinical Research LLC-Research ( Site 0037)
state: New Jersey
city: Ridgewood
country: United States
facility: The Valley Hospital ( Site 0035)
state: New Jersey
city: Washington Township
country: United States
facility: Cardiovascular Associates of the Delaware Valley ( Site 0097)
state: New Jersey
city: Bronx
country: United States
facility: CHEAR Center LLC ( Site 0009)
state: New York
city: Buffalo
country: United States
facility: Erie County Medical Center ( Site 0160)
state: New York
city: Cortlandt Manor
country: United States
facility: New York Presbyterian Medical Group Hudson Valley Cardiology ( Site 0127)
state: New York
city: New York
country: United States
facility: Icahn School of Medicine at Mount Sinai ( Site 0161)
state: New York
city: Lumberton
country: United States
facility: Southeastern Cardiology and Cardiovascular-Duke HC CRU - Lumberton ( Site 0134)
state: North Carolina
city: Wilmington
country: United States
facility: Accellacare - Wilmington ( Site 0090)
state: North Carolina
city: Canton
country: United States
facility: Aultman Hospital-Cardiology Clinical Trials ( Site 0064)
state: Ohio
city: Cincinnati
country: United States
facility: University of Cincinnati Medical Center-Cardiology ( Site 0071)
state: Ohio
city: Toledo
country: United States
facility: ProMedica Toledo Hospital-ProMedica Heart Failure Clinic ( Site 0061)
state: Ohio
city: Doylestown
country: United States
facility: Doylestown Hospital-Cardiology ( Site 0030)
state: Pennsylvania
city: Charleston
country: United States
facility: Accellacare - Charleston ( Site 0141)
state: South Carolina
city: Jackson
country: United States
facility: Apex Research Foundation ( Site 0001)
state: Tennessee
city: Nashville
country: United States
facility: Vanderbilt University Medical Center-Vanderbilt Heart and Vascular Institue ( Site 0060)
state: Tennessee
city: Dallas
country: United States
facility: Dallas VA Medical Center ( Site 0084)
state: Texas
city: Dallas
country: United States
facility: Southwest Family Medicine Associates ( Site 0131)
state: Texas
city: El Paso
country: United States
facility: Medresearch Inc ( Site 0043)
state: Texas
city: Houston
country: United States
facility: West Houston Area Clinical Trial Consultants ( Site 0014)
state: Texas
city: Kerrville
country: United States
facility: South Texas Cardiovascular Consultants, PLLC-Research ( Site 0024)
state: Texas
city: San Antonio
country: United States
facility: South Texas Cardiovascular Consultants, PLLC-Research ( Site 0020)
state: Texas
city: Tyler
country: United States
facility: Tyler Cardiovascular Consultants ( Site 0039)
state: Texas
city: Falls Church
country: United States
facility: INOVA Fairfax Medical Campus ( Site 0136)
state: Virginia
city: Manassas
country: United States
facility: Carient Heart & Vascular - Manassas ( Site 0059)
state: Virginia
city: Norfolk
country: United States
facility: Sentara Norfolk General Hospital ( Site 0114)
state: Virginia
city: Richmond
country: United States
facility: Dominion Medical Associates, Inc. ( Site 0089)
state: Virginia
city: Puyallup
country: United States
facility: Pulse Heart Institute - Puyallup ( Site 0119)
state: Washington
city: Spokane
country: United States
facility: MultiCare Health System-MultiCare Cardiology - Inland Northwest ( Site 0102)
state: Washington
city: Caba
country: Argentina
facility: CEDIC ( Site 4363)
state: Buenos Aires
city: Ciudad Autónoma de Buenos Aires
country: Argentina
facility: Centro de Investigaciones Metabólicas (CINME)-Cardiology ( Site 4352)
state: Buenos Aires
city: Ramos Mejía
country: Argentina
facility: DIM Clínica Privada ( Site 4359)
state: Buenos Aires
city: Zárate
country: Argentina
facility: Instituto de Investigaciones Clinicas Zarate ( Site 4360)
state: Buenos Aires
city: Buenos Aires
country: Argentina
facility: Centro Médico Viamonte-Clinical Research ( Site 4361)
state: Caba
city: Rosario
country: Argentina
facility: Fundacion Estudios Clinicos ( Site 4356)
state: Santa Fe
city: Santa Fe
country: Argentina
facility: Centro de Investigaciones Clinicas del Litoral ( Site 4354)
city: Brisbane
country: Australia
facility: Royal Brisbane and Women's Hospital-Cardiology Research ( Site 0453)
state: Queensland
city: Brisbane
country: Australia
facility: The Prince Charles Hospital-Cardiology Research Centre ( Site 0451)
state: Queensland
city: Brisbane
country: Australia
facility: Core Research Group ( Site 0452)
state: Queensland
city: Adelaide
country: Australia
facility: Royal Adelaide Hospital-Cardiology ( Site 0456)
state: South Australia
city: Bedford Park
country: Australia
facility: Flinders Medical Centre-Cardiology Research ( Site 0455)
state: South Australia
city: Subiaco
country: Australia
facility: St. John of God Subiaco Hospital ( Site 0457)
state: Western Australia
city: Braunau
country: Austria
facility: Krankenhaus St. Josef Braunau ( Site 0354)
state: Oberosterreich
city: Graz
country: Austria
facility: Medizinische Universität Graz-Department of Cardiology ( Site 0351)
state: Steiermark
city: Vienna
country: Austria
facility: Imed19-privat ( Site 0353)
state: Wien
city: Salzburg
country: Austria
facility: Uniklinikum Salzburg-Universitätsklinik für Innere Medizin II, Kardiologie, Internistische Intensiv
city: Wien
country: Austria
facility: Klinik Floridsdorf-Karl Landsteiner Institute for Cardiovascular and Critical Care Research c/o Dep
city: Fortaleza
country: Brazil
facility: Hospital de Messejana Dr Carlos Alberto Studart Gomes ( Site 0560)
state: Ceara
city: Goiania
country: Brazil
facility: Universidade Federal de Goias-Serviço de Cardiologia ( Site 0553)
state: Goias
city: Curitiba
country: Brazil
facility: PUC Trials- Nucleo de Pesquisa clinica da Escola de Medicina da PUCPR ( Site 0555)
state: Parana
city: Porto Alegre
country: Brazil
facility: Hospital Mae de Deus ( Site 0564)
state: Rio Grande Do Sul
city: Campinas
country: Brazil
facility: Instituto de Pesquisa clinica de Campinas ( Site 0551)
state: Sao Paulo
city: Ribeirao Preto
country: Brazil
facility: CAPED Centro Avancado Pesquisa e Diagnostica ( Site 0552)
state: Sao Paulo
city: Ribeirão Preto
country: Brazil
facility: Hospital de Clínicas de Ribeirão Preto ( Site 0559)
state: Sao Paulo
city: Acaraju
country: Brazil
facility: Centro de Pesquisa Clinica do Coracao ( Site 0561)
state: Sergipe
city: Rio de Janeiro
country: Brazil
facility: Hospital Pro-Cardiaco ( Site 0556)
city: Sao Paulo
country: Brazil
facility: Incor - Instituto do Coracao ( Site 0557)
city: Calgary
country: Canada
facility: Heritage Medical Research Clinic ( Site 0679)
state: Alberta
city: Edmonton
country: Canada
facility: University Of Alberta Hospital ( Site 0669)
state: Alberta
city: Victoria
country: Canada
facility: Victoria Heart Institute Foundation ( Site 0680)
state: British Columbia
city: Winnipeg
country: Canada
facility: St. Boniface General Hospital ( Site 0667)
state: Manitoba
city: Moncton
country: Canada
facility: G A Research Associates ( Site 0652)
state: New Brunswick
city: Halifax
country: Canada
facility: NSHA-QEII Health Sciences Centre-Dickson Bldg-Cardiology ( Site 0664)
state: Nova Scotia
city: Cambridge
country: Canada
facility: Cambridge Cardiac Care Centre ( Site 0658)
state: Ontario
city: Newmarket
country: Canada
facility: PACE Cardiology ( Site 0675)
state: Ontario
city: North York
country: Canada
facility: North York Diagnostic and Cardiac Centre ( Site 0682)
state: Ontario
city: Oakville
country: Canada
facility: Oakville Cardiovascular Research LP ( Site 0657)
state: Ontario
city: Oshawa
country: Canada
facility: Private Practice - Dr. James Cha ( Site 0655)
state: Ontario
city: Peterborough
country: Canada
facility: Kawartha Cardiology Clinical Trials ( Site 0654)
state: Ontario
city: Toronto
country: Canada
facility: Corcare-Corcare Cardiovascular Research ( Site 0660)
state: Ontario
city: Toronto
country: Canada
facility: Medicus MFC Research Clinic ( Site 0676)
state: Ontario
city: Laval
country: Canada
facility: Hôpital de la Cité-de-la-Santé ( Site 0673)
state: Quebec
city: Montreal
country: Canada
facility: Institut de Cardiologie de Montreal ( Site 0661)
state: Quebec
city: Montreal
country: Canada
facility: Montreal General Hospital ( Site 0653)
state: Quebec
city: Sherbrooke
country: Canada
facility: Centre intégré universitaire de santé et de services sociaux de l'Estrie - Centre Hospitalier Univer
state: Quebec
city: St-Jerome
country: Canada
facility: Unité de Recherche Clinique du CISSS des Laurentides ( Site 0668)
state: Quebec
city: Terrebonne
country: Canada
facility: Hopital Pierre-Le Gardeur ( Site 0674)
state: Quebec
city: Trois-Rivieres
country: Canada
facility: Diex Recherche Trois-Rivieres ( Site 0677)
state: Quebec
city: Temuco
country: Chile
facility: Centro De Estudios Cardiologicos Y De Medicina Interna ( Site 0752)
state: Araucania
city: La Serena
country: Chile
facility: IC La Serena Research ( Site 0769)
state: Coquimbo
city: Osorno
country: Chile
facility: Clinica Alemana Osorno ( Site 0768)
state: Los Lagos
city: Valdivia
country: Chile
facility: Clinical Research Chile SpA ( Site 0761)
state: Los Rios
city: Santiago
country: Chile
facility: Enroll SpA ( Site 0755)
state: Region M. De Santiago
city: Santiago
country: Chile
facility: Clinica Dermacross ( Site 0760)
state: Region M. De Santiago
city: Santiago
country: Chile
facility: Espacio Eme ( Site 0762)
state: Region M. De Santiago
city: Santiago
country: Chile
facility: Hospital y CRS El Pino ( Site 0763)
state: Region M. De Santiago
city: Santiago
country: Chile
facility: Universidad de Chile - Hospital Clínico Universidad de Chile ( Site 0754)
state: Region M. De Santiago
city: Santiago
country: Chile
facility: Clínica Ensenada ( Site 0753)
state: Region M. De Santiago
city: Santiago
country: Chile
facility: Cardio Sur ( Site 0756)
state: Region M. De Santiago
city: Viña del Mar
country: Chile
facility: ONCOCENTRO APYS ( Site 0770)
state: Valparaiso
city: Hefei
country: China
facility: Anhui Provincil Hospital South District ( Site 0920)
state: Anhui
city: Beijing
country: China
facility: Beijing Anzhen Hospital, Capital Medical University-Cardiovascular ( Site 0856)
state: Beijing
city: Beijing
country: China
facility: Aero Space Center Hospital ( Site 0918)
state: Beijing
city: Beijing
country: China
facility: Beijing Friendship Hospital-Cardology ( Site 0865)
state: Beijing
city: Beijing
country: China
facility: Beijing Tsinghua Changgung Hospital ( Site 0911)
state: Beijing
city: Chongqing
country: China
facility: The Second Affiliated Hospital Chongqing Medical University-Department of Cardiology ( Site 0908)
state: Chongqing
city: Wanzhou
country: China
facility: Chongqing Three Gorges Central Hospital ( Site 0913)
state: Chongqing
city: Lanzhou
country: China
facility: Lanzhou university second hospital-Lanzhou university second hospital ( Site 0863)
state: Gansu
city: Foshan
country: China
facility: The First People's Hospital of Foshan ( Site 0898)
state: Guangdong
city: Guangzhou
country: China
facility: Guangdong Provincial People's Hospital-Cardiology ( Site 0852)
state: Guangdong
city: Guangzhou
country: China
facility: Sun Yat-sen Memorial Hospital, Sun Yat-sen University-Cardiology ( Site 0868)
state: Guangdong
city: Guangzhou
country: China
facility: The First Affiliated Hospital of Jinan University ( Site 0897)
state: Guangdong
city: Shenzhen
country: China
facility: The University of Hong Kong - Shenzhen Hospital-Cardiovascular department ( Site 0895)
state: Guangdong
city: Haikou
country: China
facility: Hainan General Hospital ( Site 0894)
state: Hainan
city: Harbin
country: China
facility: The First Hospital of Harbin Medical University-Cardiology ( Site 0903)
state: Heilongjiang
city: Wuhan
country: China
facility: Wuhan Union Hospital ( Site 0919)
state: Hubei
city: Changsha
country: China
facility: Changsha Central Hospital ( Site 0854)
state: Hunan
city: ChangSha
country: China
facility: Hunan Provincial People's Hospital ( Site 0857)
state: Hunan
city: Changsha
country: China
facility: Xiangya Hospital Central South University-Cardiological Department ( Site 0899)
state: Hunan
city: Changsha
country: China
facility: The Third Xiangya Hospital of Central South University-Cardiology ( Site 0860)
state: Hunan
city: Bao Tou
country: China
facility: BAO TOU CENTRAL HOSPITAL ( Site 0866)
state: Inner Mongolia
city: Nanjing
country: China
facility: Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School-Cardiolggy
state: Jiangsu
city: Nanjing
country: China
facility: The Second Affiliated Hospital of Nanjing Medical University-Cardiology ( Site 0900)
state: Jiangsu
city: Wuxi
country: China
facility: Wuxi No.2 People's Hospital-Cardiology Department ( Site 0877)
state: Jiangsu
city: Wuxi
country: China
facility: Wuxi People's Hospital-Cardiovascular Department ( Site 0870)
state: Jiangsu
city: Xuzhou
country: China
facility: The Affiliated Hospital of Xuzhou Medical College ( Site 0910)
state: Jiangsu
city: Yangzhou
country: China
facility: Northern Jiangsu People's Hospital ( Site 0861)
state: Jiangsu
city: Zhenjiang
country: China
facility: Affiliated Hospital of Jiangsu University-Cardiology Department ( Site 0917)
state: Jiangsu
city: Nanchang
country: China
facility: The Second Affiliated Hospital of Nanchang University-Cardiology ( Site 0912)
state: Jiangxi
city: Changchun
country: China
facility: China-Japan Union Hospital-department of cardiology ( Site 0916)
state: Jilin
city: Siping
country: China
facility: Siping Central People's Hospital-Cardiovascular Department ( Site 0915)
state: Jilin
city: Shenyang
country: China
facility: The People's Hospital of Liaoning Province ( Site 0859)
state: Liaoning
city: Xi'an
country: China
facility: The First Affiliated Hospital of Xian Jiaotong University ward1 depattment of medical oncology ( Sit
state: Shaanxi
city: Xian
country: China
facility: Shaanxi provincial people's hospital ( Site 0853)
state: Shaanxi
city: Shanghai
country: China
facility: Shanghai Jiaotong University School of Medicine Ruijin Hospital-Cardiology Department ( Site 0855)
state: Shanghai
city: Shanghai
country: China
facility: Zhongshan Hospital,Fudan University-Cardiology ( Site 0851)
state: Shanghai
city: Shanghai
country: China
facility: Shanghai Tongji Hospital-Cardiovascular Department ( Site 0905)
state: Shanghai
city: Shanghai
country: China
facility: Shanghai Yangpu District Central Hospital-Cardiology ( Site 0876)
state: Shanghai
city: Shanghai
country: China
facility: Shanghai Xuhui Central Hospital-Cardiovascular Department ( Site 0872)
state: Shanghai
city: Cheng Du
country: China
facility: West China Hospital Sichuan University ( Site 0904)
state: Sichuan
city: Tianjin
country: China
facility: The Second Hospital of Tianjin Medical University-Endocrinology ( Site 0902)
state: Tianjin
city: Tianjin
country: China
facility: Tianjin Chest Hospital-Cardiology ( Site 0901)
state: Tianjin
city: Tianjin
country: China
facility: Tianjin People' s Hospital ( Site 0867)
state: Tianjin
city: Hangzhou
country: China
facility: The First Affiliated Hospital, Zhejiang University ( Site 0907)
state: Zhejiang
city: Hangzhou
country: China
facility: The Second Affiliated hospital of Zhejiang University school of medicine ( Site 0909)
state: Zhejiang
city: Hangzhou
country: China
facility: Zhejiang Provincial People's Hospital ( Site 0914)
state: Zhejiang
city: Lishui
country: China
facility: People's Hospital of Lishui City-department of cardiovascular ( Site 0862)
state: Zhejiang
city: Wenzhou
country: China
facility: The First Affiliated Hospital of Wenzhou Medical University-Vasculocardiology Department ( Site 0874
state: Zhejiang
city: Medellín
country: Colombia
facility: Fundación Centro de Investigación Clínica CIC ( Site 0955)
state: Antioquia
city: Medellín
country: Colombia
facility: Centro Cardiovascular Colombiano Clínica Santa María ( Site 0951)
state: Antioquia
city: Medellín
country: Colombia
facility: Rodrigo Botero S.A.S ( Site 0953)
state: Antioquia
city: Barranquilla
country: Colombia
facility: Clinica de la Costa S.A.S. ( Site 0954)
state: Atlantico
city: Barranquilla
country: Colombia
facility: Corazon IPS ( Site 0964)
state: Atlantico
city: Barranquilla
country: Colombia
facility: IPS Centro Científico Asistencial S.A.S ( Site 0952)
state: Atlantico
city: Manizales
country: Colombia
facility: IPS Médicos Internistas de Caldas ( Site 0959)
state: Caldas
city: Bucaramanga
country: Colombia
facility: Instituto Del Corazón De Bucaramanga ( Site 0960)
state: Santander
city: Piedecuesta
country: Colombia
facility: Fundación Cardiovascular de Colombia ( Site 0961)
state: Santander
city: Cali
country: Colombia
facility: Fundacion Valle del Lili- CIC-Internal Medicine ( Site 0962)
state: Valle Del Cauca
city: Cali
country: Colombia
facility: Centro de Investigaciones Clinicas SAS ( Site 0957)
state: Valle Del Cauca
city: Cali
country: Colombia
facility: Clínica Imbanaco S.A.S ( Site 0963)
state: Valle Del Cauca
city: Brno
country: Czechia
facility: Fakultní nemocnice Brno Bohunice-Interni kardiologicka klinika ( Site 1058)
state: Brno-mesto
city: Brno
country: Czechia
facility: Vojenská Nemocnice Brno-Internal department ( Site 1055)
state: Brno-mesto
city: Brno
country: Czechia
facility: MUDr. Libor Nechvatal s.r.o. , Kardiologie ( Site 1057)
state: Jihomoravsky Kraj
city: Brno
country: Czechia
facility: Fakultni Nemocnice u sv. Anny v Brne-I. interni kardioangiologicka klinika ( Site 1066)
state: Jihomoravsky Kraj
city: Mladá Boleslav
country: Czechia
facility: Klinika Dr. Pirka ( Site 1065)
state: Mlada Boleslav
city: Prague
country: Czechia
facility: Institut Klinicke a Experimentalni Mediciny-Klinika kardiologie ( Site 1052)
state: Praha 4
city: Praha
country: Czechia
facility: Ustredni vojenska nemocnice-Oddeleni kardiologie ( Site 1054)
state: Praha 6
city: Slany
country: Czechia
facility: Nemocnice Slany-Interna - kardiologicka ambulance ( Site 1063)
state: Stredocesky Kraj
city: Louny
country: Czechia
facility: KardioBusak s.r.o. ( Site 1051)
city: Praha 2
country: Czechia
facility: Vseobecna fakultni nemocnice v Praze-Centrum srdečního selhání ( Site 1059)
city: Znojmo
country: Czechia
facility: KIGE ( Site 1060)
city: Copenhagen
country: Denmark
facility: Rigshospitalet-Cardiology ( Site 1161)
state: Hovedstaden
city: CPH
country: Denmark
facility: Amager Hospital ( Site 1163)
state: Hovedstaden
city: Hellerup
country: Denmark
facility: Herlev and Gentofte Hospital-Department of Cardiology ( Site 1158)
state: Hovedstaden
city: Hillerod
country: Denmark
facility: Nordsjællands Hospital - Hillerød ( Site 1159)
state: Hovedstaden
city: Hvidovre
country: Denmark
facility: Hvidovre Hospital-259 ( Site 1151)
state: Hovedstaden
city: Aarhus
country: Denmark
facility: Aarhus Universitetshospital, Skejby ( Site 1160)
state: Midtjylland
city: Viborg
country: Denmark
facility: Regionshospitalet Viborg ( Site 1166)
state: Midtjylland
city: Hjorring
country: Denmark
facility: Sygehus Vendsyssel Hjoerring ( Site 1164)
state: Nordjylland
city: Holbaek
country: Denmark
facility: Holbæk Sygehus-Cardiology ( Site 1152)
state: Sjaelland
city: Roskilde
country: Denmark
facility: Roskilde Sygehus ( Site 1162)
state: Sjaelland
city: Slagelse
country: Denmark
facility: Slagelse Sygehus-Ambulatorium for Hjertesygdomme ( Site 1153)
state: Sjaelland
city: Esbjerg
country: Denmark
facility: Sydvestjysk Sygehus Esbjerg-Hjertemedicinsk Projekt ( Site 1154)
state: Syddanmark
city: Svendborg
country: Denmark
facility: Svendborg Hospital Odense Universitets hospital-Kardiologisk Forskningsenhed ( Site 1156)
state: Syddanmark
city: Nice
country: France
facility: Centre Hospitalier Universitaire de Nice - Hopital Pasteur-Service cardiologie ( Site 1353)
state: Alpes-Maritimes
city: Pessac
country: France
facility: CHU Bordeaux Haut-Leveque ( Site 1362)
state: Aquitaine
city: Le Coudray
country: France
facility: Centre Hospitalier Louis Pasteur ( Site 1360)
state: Eure-et-Loir
city: Toulouse
country: France
facility: CHU Rangueil-Cardiology ( Site 1351)
state: Haute-Garonne
city: Rouen
country: France
facility: CHU Charles Nicolle ( Site 1354)
state: Haute-Normandie
city: Paris
country: France
facility: Pitie Salpetriere University Hospital ( Site 1363)
state: Ile-de-France
city: Vandoeuvre lès Nancy
country: France
facility: Centre Hospitalier Régional Universitaire de Nancy - Hôpitau-Centre Investigation Clinique Plurithé
state: Lorraine
city: Le Kremlin-Bicêtre
country: France
facility: Hôpitaux Universitaires Paris Sud - Hôpital Bicêtre ( Site 1356)
state: Paris
city: Toulon
country: France
facility: Centre Hospitalier intercommunal de Toulon La Seyne sur Mer ( Site 1352)
state: Provence-Alpes-Cote-d Azur
city: Lyon
country: France
facility: Hospices Civils de Lyon - Hopital Louis Pradel ( Site 1364)
state: Rhone
city: La Roche-sur-Yon
country: France
facility: CHD Vendee ( Site 1361)
state: Vendee
city: Heidelberg
country: Germany
facility: Universitaetsklinikum Heidelberg-Klinik für Kardiologie, Angiologie und Pneumologie ( Site 1475)
state: Baden-Wurttemberg
city: Coburg
country: Germany
facility: Klinikum Coburg ( Site 1464)
state: Bayern
city: Nuremberg
country: Germany
facility: Kardiologische Gemeinschaftspraxis ( Site 1460)
state: Bayern
city: Wuerzburg
country: Germany
facility: Universitaetsklinikum Wuerzburg ( Site 1458)
state: Bayern
city: Frankfurt
country: Germany
facility: ClinPhenomics CVC GmbH ( Site 1457)
state: Hessen
city: Frankfurt
country: Germany
facility: Klinikum Frankfurt Höchst ( Site 1463)
state: Hessen
city: Langen
country: Germany
facility: Asklepios Klinik Langen ( Site 1473)
state: Hessen
city: Greifswald
country: Germany
facility: Universitätsmedizin Greifswald ( Site 1470)
state: Mecklenburg-Vorpommern
city: Hannover
country: Germany
facility: Medizinische Hochschule Hannover ( Site 1476)
state: Niedersachsen
city: Cologne
country: Germany
facility: St. Vinzenz-Hospital-Cardiology ( Site 1455)
state: Nordrhein-Westfalen
city: Leverkusen
country: Germany
facility: Klinikum Leverkusen ( Site 1453)
state: Nordrhein-Westfalen
city: Mönchengladbach
country: Germany
facility: Kliniken Maria Hilf-Klinik für Kardiologie ( Site 1454)
state: Nordrhein-Westfalen
city: Siegen
country: Germany
facility: Gemeinschaftspraxis Dr. Fabian Krämer, Dr. Ulrich Overhoff ( Site 1459)
state: Nordrhein-Westfalen
city: Ludwigshafen
country: Germany
facility: Klinikum Ludwigshafen ( Site 1456)
state: Rheinland-Pfalz
city: Neuwied
country: Germany
facility: Marienhaus Klinikum St. Elisabeth Neuwied ( Site 1452)
state: Rheinland-Pfalz
city: Dresden
country: Germany
facility: Staedtisches Klinikum Dresden-2. Medizinische Klinik ( Site 1468)
state: Sachsen
city: Dresden
country: Germany
facility: Hausärztlich-Kardiologisches MVZ am Felsenkeller GmbH/Zentrum für klinische Studien ( Site 1477)
state: Sachsen
city: Dresden
country: Germany
facility: Herzzentrum Dresden GmbH Universitätsklinik ( Site 1469)
state: Sachsen
city: Erfurt
country: Germany
facility: Katholisches Krankenhaus St. Johann Nepomuk ( Site 1462)
state: Thuringen
city: Berlin
country: Germany
facility: Praxis Rankestrasse ( Site 1461)
city: Hamburg
country: Germany
facility: Cardiologicum Hamburg ( Site 1467)
city: Athens
country: Greece
facility: General Hospital of Athens Hippokratio ( Site 1552)
state: Attiki
city: Athens
country: Greece
facility: General Hospital of Athens "G. Gennimatas"-General Hospital of Athens "G.Gennimatas" ( Site 1561)
state: Attiki
city: Athens
country: Greece
facility: Konstantopoulio General Hospital-Cardiology Clinic ( Site 1553)
state: Attiki
city: Athina
country: Greece
facility: Alexandra Hospital-HEART FAILURE AND CARDIO-ONCOLOGY UNIT ( Site 1559)
state: Attiki
city: Chaidari
country: Greece
facility: ATTIKON GENERAL UNIVERSITY HOSPITAL ( Site 1556)
state: Attiki
city: Marousi
country: Greece
facility: Hygeia Hospital-6th cardiology clinic ( Site 1560)
state: Attiki
city: Ioannina
country: Greece
facility: University Hospital of Ioannina-2nd Department of Cardiology ( Site 1554)
state: Dytiki Ellada
city: Alexanroupolis
country: Greece
facility: University Hospital of Alexandroupolis-First Department of Internal Medicine ( Site 1551)
state: Evros
city: Larissa
country: Greece
facility: University General Hospital of Larissa ( Site 1555)
state: Thessalia
city: Thessaloniki
country: Greece
facility: AHEPA University General Hospital of Thessaloniki-1st Cardiology Clinic ( Site 1558)
city: Thessaloniki
country: Greece
facility: European Interbalkan Medical Center-2nd Department of Cardiology ( Site 1557)
city: Guatemala City
country: Guatemala
facility: Unidad De Diagnostico Cardiologico ( Site 1652)
city: Guatemala
country: Guatemala
facility: Clinica Medica ( Site 1651)
city: Guatemala
country: Guatemala
facility: Unidad De Diagnostico Cardiologico ( Site 1654)
city: Aberdeen
country: Hong Kong
facility: Grantham Hospital ( Site 1753)
city: Hksar
country: Hong Kong
facility: Queen Mary Hospital-Medicine - Cardiology ( Site 1752)
city: Hong Kong
country: Hong Kong
facility: Princess Margaret Hospital ( Site 1755)
city: Shatin
country: Hong Kong
facility: Prince of Wales Hospital ( Site 1751)
city: Kecskemét
country: Hungary
facility: Bacs-Kiskun Megyei Korhaz-I. Belgyógyászat - Kardiológia ( Site 1873)
state: Bacs-Kiskun
city: Pécs
country: Hungary
facility: CoroMed ( Site 1867)
state: Baranya
city: Pécs
country: Hungary
facility: Pécsi Tudományegyetem Klinikai Központ ( Site 1865)
state: Baranya
city: Békéscsaba
country: Hungary
facility: Private Practice - Dr. Lakatos Ferenc ( Site 1854)
state: Bekes
city: Gyula
country: Hungary
facility: Békés Megyei Központi Kórház Pándy Kálmán Tagkórház-Cardiology ( Site 1878)
state: Bekes
city: Szeged
country: Hungary
facility: Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ-Belgyógyászati Klinika ( Site 1874)
state: Csongrad
city: Mosonmagyaróvár
country: Hungary
facility: TaNa Med ( Site 1866)
state: Gyor-Moson-Sopron
city: Kistarcsa
country: Hungary
facility: Flor Ferenc Hospital of Pest County-5th Department of Internal Medicine ( Site 1852)
state: Pest
city: Székesfehérvár
country: Hungary
facility: CMed Rehabilitacios es Diagnosztikai Kozpont ( Site 1877)
state: Szekesfehervar
city: Szekszárd
country: Hungary
facility: Tolna Megyei Balassa János Kórház ( Site 1868)
state: Szekszard
city: Balatonfüred
country: Hungary
facility: DRC Gyógyszervizsgáló Központ ( Site 1869)
state: Veszprem
city: Budapest
country: Hungary
facility: Szent Rókus Kórház ( Site 1858)
city: Budapest
country: Hungary
facility: Gottsegen György Országos Kardiovaszkuláris Intézet ( Site 1851)
city: Budapest
country: Hungary
facility: Semmelweis University-Városmajori Szív- és Érgyógyászati Klinika ( Site 1855)
city: Budapest
country: Hungary
facility: Óbudai Egészségügyi Centrum ( Site 1861)
city: Nyiregyhaza
country: Hungary
facility: Medifarma 98 Kft-Outpatient Clinic ( Site 1859)
city: Zalaegerszeg
country: Hungary
facility: OEC Clinical Research - Zalaegerszeg ( Site 1864)
city: Dun Laoghaire
country: Ireland
facility: St. Michael's Hospital ( Site 1955)
state: Dublin
city: Dublin
country: Ireland
facility: St. James's Hospital-Cardiology ( Site 1951)
city: Ashdod
country: Israel
facility: Assuta Ashdod Medical Center-Cardiology ( Site 2063)
city: Hadera
country: Israel
facility: Hillel Yaffe Medical Center-Heart Institute ( Site 2058)
city: Haifa
country: Israel
facility: Rambam Health Care Campus-Cardiology ( Site 2053)
city: Jerusalem
country: Israel
facility: Shaare Zedek Medical Center-Cardiology ( Site 2055)
city: Jerusalem
country: Israel
facility: Hadassah Medical Center-Heart Institute ( Site 2062)
city: Nahariya
country: Israel
facility: Galilee Medical Center-Cardiology ( Site 2051)
city: Petah-Tikva
country: Israel
facility: Rabin Medical Center-Cardiology - CHF ( Site 2052)
city: Ramat Gan
country: Israel
facility: Sheba Medical Center-Leviev Heart Center ( Site 2064)
city: Rehovot
country: Israel
facility: Kaplan Medical Center-Heart Institution ( Site 2054)
city: Zerifin
country: Israel
facility: Yitzhak Shamir Medical Center-Cardiology ( Site 2060)
city: Cona
country: Italy
facility: Azienda Ospedaliero Universitaria S.Anna ( Site 2152)
state: Emilia-Romagna
city: Trieste
country: Italy
facility: Cattinara Hospital-Cardiovascular Department ( Site 2162)
state: Friuli-Venezia Giulia
city: Roma
country: Italy
facility: Policlinico Umberto I ( Site 2166)
state: Lazio
city: Milano
country: Italy
facility: Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico-U.O.C. Cardiologia ( Site 2161)
state: Lombardia
city: Milano
country: Italy
facility: Centro Cardiologico Monzino-Heart Failure Unit ( Site 2153)
state: Lombardia
city: Milan
country: Italy
facility: ASST Grande Ospedale Metropolitano Niguarda-Unità Ricerche Cliniche della Cardiologia 4 ( Site 2159)
state: Milano
city: Rome
country: Italy
facility: IRCCS San Raffaele Pisana-riabilitazione cardiologica ( Site 2156)
state: Roma
city: Siena
country: Italy
facility: ospedale le scotte ( Site 2163)
state: Toscana
city: Bergamo
country: Italy
facility: Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII-Cardiologia 1 ( Site 2151)
city: Bologna
country: Italy
facility: IRCCS - AOU di Bologna-Dept. of Medical and Surgical sciences ( Site 2158)
city: Brescia
country: Italy
facility: Azienda Ospedaliera Spedali Civili di Brescia-Cardiology- Day Hospital ( Site 2154)
city: Pavia
country: Italy
facility: Fondazione IRCCS Policlinico San Matteo-Cardiology ( Site 2157)
city: Perugia
country: Italy
facility: University of Perugia ( Site 2164)
city: Torino
country: Italy
facility: Azienda Ospedaliero-Universitaria Città della Salute e della Scienza di Torino ( Site 2165)
city: Cheongju-si
country: Korea, Republic of
facility: Chungbuk National University Hospital-Internal medicine ( Site 3551)
state: Chungbuk
city: Namdong-gu
country: Korea, Republic of
facility: Gachon University Gil Medical Center ( Site 3559)
state: Incheon
city: Wonju
country: Korea, Republic of
facility: Yonsei University-Wonju Severance Christian Hospital ( Site 3555)
state: Kang-won-do
city: Gwangju-si
country: Korea, Republic of
facility: Chonnam National University Hospital ( Site 3558)
state: Kwangju-Kwangyokshi
city: Anyang-si
country: Korea, Republic of
facility: Hallym University Sacred Heart Hospital-Cardiovascular center ( Site 3556)
state: Kyonggi-do
city: Busan
country: Korea, Republic of
facility: Pusan National University Hospital-Internal Medicine ( Site 3553)
state: Pusan-Kwangyokshi
city: Jung-gu
country: Korea, Republic of
facility: Chungnam national university hospital ( Site 3554)
state: Taejon-Kwangyokshi
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital ( Site 3557)
city: Seoul
country: Korea, Republic of
facility: Severance Hospital, Yonsei University Health System ( Site 3552)
city: Alor Setar
country: Malaysia
facility: Hospital Sultanah Bahiyah-Department of Cardiology ( Site 2355)
state: Kedah
city: Kubang Kerian
country: Malaysia
facility: Hospital Universiti Sains Malaysia-Medical Department ( Site 2357)
state: Kelantan
city: Lembah Pantai
country: Malaysia
facility: University Malaya Medical Centre ( Site 2351)
state: Kuala Lumpur
city: Kuantan
country: Malaysia
facility: Hospital Tengku Ampuan Afzan ( Site 2353)
state: Pahang
city: Kota Kinabalu
country: Malaysia
facility: Hospital Queen Elizabeth II ( Site 2359)
state: Sabah
city: Kota Samarahan
country: Malaysia
facility: Sarawak Heart Centre ( Site 2352)
state: Sarawak
city: Sungai Buloh
country: Malaysia
facility: UiTM Sungai Buloh Campus ( Site 2354)
state: Selangor
city: Kuala Terengganu
country: Malaysia
facility: Hospital Sultanah Nur Zahirah-Jabatan Perubatan ( Site 2360)
state: Terengganu
city: Tijuana
country: Mexico
facility: Centro de Investigacion Cardiovascular y Metabólica ( Site 2465)
state: Baja California
city: Chihuahua City
country: Mexico
facility: Medivest Centro de Investigación Integral ( Site 2460)
state: Chihuahua
city: Torreon
country: Mexico
facility: CIMAB SA de CV ( Site 2456)
state: Coahuila
city: Mexico City
country: Mexico
facility: Centro de Imagen y Tecnología en Intervención Cardiovascular ( Site 2477)
state: Distrito Federal
city: Mexico City
country: Mexico
facility: Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran ( Site 2474)
state: Distrito Federal
city: Mexico
country: Mexico
facility: Instituto Nacional de Cardiologia Ignacio Chavez ( Site 2454)
state: Distrito Federal
city: México
country: Mexico
facility: HOSPITAL GENERAL DE MEXICO DR. EDUARDO LICEAGA ( Site 2478)
state: Distrito Federal
city: Acapulco
country: Mexico
facility: Hospital General de Acapulco ( Site 2469)
state: Guerrero
city: Pachuca
country: Mexico
facility: Grupo Ollin Care ( Site 2476)
state: Hidalgo
city: Guadalajara
country: Mexico
facility: Unidad de Investigaci�n Cl�nica Cardiometabolica de Occidente ( Site 2466)
state: Jalisco
city: Guadalajara
country: Mexico
facility: Cardiocent de Guadalajara S.C. ( Site 2464)
state: Jalisco
city: Guadalajara
country: Mexico
facility: Instituto Jalisciense de Metabolismo SC ( Site 2467)
state: Jalisco
city: Monterrey
country: Mexico
facility: Unidad biomedica avanzada monterrey ( Site 2462)
state: Nuevo Leon
city: San Nicolás de los Garza
country: Mexico
facility: Unidad Médica para la Salud Integral ( Site 2472)
state: Nuevo Leon
city: San Luis Potosí
country: Mexico
facility: Centro de Atención e Investigación Cardiovascular del Potosí ( Site 2453)
state: San Luis Potosi
city: Mazatlán
country: Mexico
facility: Centro de Estudios de Alta Especialidad de Sinaloa ( Site 2463)
state: Sinaloa
city: Ciudad Madero
country: Mexico
facility: Centro de Estudios de Investigacion Metabolicos y Cardiovasculares ( Site 2468)
state: Tamaulipas
city: Xalapa-Enríquez
country: Mexico
facility: Hospital Angeles Xalapa ( Site 2451)
state: Veracruz
city: Xalapa
country: Mexico
facility: Consultorio de Medicina Especilizada del Sector Privado ( Site 2455)
state: Veracruz
city: Merida
country: Mexico
facility: Medical Care and Research SA de CV ( Site 2461)
state: Yucatan
city: Aguascalientes
country: Mexico
facility: Fundación Cardiovascular de Aguascalientes A.C. ( Site 2473)
city: Oaxaca
country: Mexico
facility: Oaxaca Site Management Organization ( Site 2459)
city: Oaxaca
country: Mexico
facility: Centro de Investigacion Clinica de Oaxaca ( Site 2457)
city: Christchurch
country: New Zealand
facility: Christchurch Heart Institute ( Site 2651)
state: Canterbury
city: Dunedin
country: New Zealand
facility: Dunedin Hospital-Cardiology Department ( Site 2653)
state: Otago
city: Hamilton
country: New Zealand
facility: Waikato Hospital-Cardiology Clinical Trials Unit ( Site 2654)
state: Waikato
city: Lower Hutt
country: New Zealand
facility: Hutt Valley District Health board HVDHB-Cardiology Research Unit ( Site 2652)
state: Wellington
city: Auckland
country: New Zealand
facility: North Shore Hospital-Cardiology Research ( Site 2656)
city: Auckland
country: New Zealand
facility: Auckland City Hospital ( Site 2659)
city: Auckland
country: New Zealand
facility: Middlemore Clinical Trials ( Site 2658)
city: Trujillo
country: Peru
facility: Centro de investigacion Clínica Trujillo-Medical specialties ( Site 2860)
state: La Libertad
city: Jesús María
country: Peru
facility: Instituto Nacional Cardiovascular INCOR Carlos Peschiera Carrillo - EsSalud ( Site 2855)
state: Lima
city: Bellavista
country: Peru
facility: Hospital Alberto Sabogal Sologuren ( Site 2851)
state: Qallaw
city: Lima
country: Peru
facility: Clínica Vesalio-Cardiology ( Site 2854)
city: Lima
country: Peru
facility: Clínica Javier Prado ( Site 2853)
city: Lima
country: Peru
facility: Clínica El Golf-Cardiologia ( Site 2857)
city: Lima
country: Peru
facility: Clínica Providencia ( Site 2856)
city: Lima
country: Peru
facility: Hospital Cayetano Heredia-Servicio de cardiologia ( Site 2852)
city: Piura
country: Peru
facility: Clínica Belén ( Site 2858)
city: Legnica
country: Poland
facility: Beata Miklaszewicz & Dariusz Dabrowski CARDIAMED s.j. ( Site 3070)
state: Dolnoslaskie
city: Wrocaw
country: Poland
facility: Instytut Chorób Serca, Zakład Badań Klinicznych Chorób Układu Krążenia ( Site 3057)
state: Dolnoslaskie
city: Bydgoszcz
country: Poland
facility: NZOZ Centrum Medyczne KERmed ( Site 3066)
state: Kujawsko-pomorskie
city: Torun
country: Poland
facility: Praktyka Lekarska Lidia Pawlowicz ( Site 3053)
state: Kujawsko-pomorskie
city: Toruń
country: Poland
facility: Wojewodzki Szpital Zespolony im Ludwika Rydygiera w Toruniu-Oddz.Klin.Kardiologii i Int.T.Kard. ( Si
state: Kujawsko-pomorskie
city: Lublin
country: Poland
facility: NZOZ Twoja Przychodnia ( Site 3051)
state: Lubelskie
city: Pulawy
country: Poland
facility: SP ZOZ w Puławach- Oddział Kardiologii ( Site 3071)
state: Lubelskie
city: Chrzanow
country: Poland
facility: Polsko-Amerykańskie Kliniki Serca PAKS Małopolskie Centrum Sercowo-Naczyniowe ( Site 3062)
state: Malopolskie
city: Krakow
country: Poland
facility: Centrum Medyczne Zdrowa J. Trebacz, W. Zajdel Sp. J. ( Site 3061)
state: Malopolskie
city: Tarnów
country: Poland
facility: Private Practice - Dr. Robert Witek-Ośrodek Badań Klinicznych "METABOLICA" Lek. Robert Witek ( Site
state: Malopolskie
city: Warszawa
country: Poland
facility: ETG Warszawa ( Site 3052)
state: Mazowieckie
city: Kedzierzyn-Kozle
country: Poland
facility: Polsko-Amerykańskie Kliniki Serca ( Site 3077)
state: Opolskie
city: Rzeszow
country: Poland
facility: Centrum Medyczne Medyk ( Site 3065)
state: Podkarpackie
city: Sokolka
country: Poland
facility: Centrum Medyczne Dr Sudnik s.c. Wanda i Jerzy Sudnik ( Site 3073)
state: Podlaskie
city: Gdynia
country: Poland
facility: Indywidualna Specjalistyczna Praktyka Lekarska w Dziedzinie Kardiologii Lek. med. Krzysztof Cymerman
state: Pomorskie
city: Bayamon
country: Puerto Rico
facility: Cooperativa De Facultad Medica Sanacoop-Instituto Sanacoop ( Site 3151)
city: Humacao
country: Puerto Rico
facility: Private Practice - Dr. Yolanda Figueroa-Torres ( Site 3156)
city: Ponce
country: Puerto Rico
facility: Research and Cardiovascular Corp. ( Site 3152)
city: Rio Grande
country: Puerto Rico
facility: Caparra Internal Medicine ( Site 3155)
city: San Juan
country: Puerto Rico
facility: VA Caribbean Healthcare System ( Site 3157)
city: Ivanovo
country: Russian Federation
facility: Ivanovo Regional Healthcare Institution Cardiology Dispensary ( Site 3265)
state: Ivanovskaya Oblast
city: Krasnodar
country: Russian Federation
facility: Krasnodar Regional Clinical Hospital Number 1 S.V. Ochapovskogo ( Site 3281)
state: Krasnodarskiy Kray
city: Sochi
country: Russian Federation
facility: City Hospital No. 4 ( Site 3269)
state: Krasnodarskiy Kray
city: Saint Petersburg
country: Russian Federation
facility: First Pavlov State Medical University of Saint Petersburg-Сardiology department ( Site 3257)
state: Leningradskaya Oblast
city: Moscow
country: Russian Federation
facility: State budgetary Healthcare Institution of the city of Moscow "V. V. Vinogradov City Clinical Hospita
state: Moskva
city: Omsk
country: Russian Federation
facility: Omsk Regional Clinical Health Service Number 9 ( Site 3296)
state: Omskaya Oblast
city: Perm
country: Russian Federation
facility: Perm Regional Hospital for War Veterans ( Site 3272)
state: Permskiy Kray
city: Rostov-on-Don
country: Russian Federation
facility: Rostov State Medical University ( Site 3259)
state: Rostovskaya Oblast
city: Rostov-on-Don
country: Russian Federation
facility: Rostov-on-Don City Emergency Hospital ( Site 3271)
state: Rostovskaya Oblast
city: Ryazan
country: Russian Federation
facility: Ryazan State Medical University named after Academician I.P. Pavlova ( Site 3260)
state: Ryazanskaya Oblast
city: Saint Petersburg
country: Russian Federation
facility: First Pavlov State Medical University of Saint Petersburg ( Site 3288)
state: Sankt-Peterburg
city: Saint Petersburg
country: Russian Federation
facility: Almazov National Medical Research Centre ( Site 3320)
state: Sankt-Peterburg
city: Saint Petersburg
country: Russian Federation
facility: Pokrovskaya Municipal Hospital ( Site 3252)
state: Sankt-Peterburg
city: Saint Petersburg
country: Russian Federation
facility: Pokrovskaya Municipal Hospital-1-st cardiology department ( Site 3251)
state: Sankt-Peterburg
city: Saint-Petersburg
country: Russian Federation
facility: Astarta Clinic ( Site 3276)
state: Sankt-Peterburg
city: Saratov
country: Russian Federation
facility: Clinical Hospital S.R.Mirotvortseva name SSMU ( Site 3254)
state: Saratovskaya Oblast
city: Kazan
country: Russian Federation
facility: Interregional Clinical Diagnostic Center-Department of Clinical Trials ( Site 3307)
state: Tatarstan, Respublika
city: Volgograd
country: Russian Federation
facility: Volgograd State Medical University ( Site 3258)
state: Volgogradskaya Oblast
city: Sankt-Peterburg
country: Russian Federation
facility: Institute for Medical Research ( Site 3316)
city: Singapore
country: Singapore
facility: National Heart Centre Singapore ( Site 3351)
state: Central Singapore
city: Singapore
country: Singapore
facility: Tan Tock Seng Hospital ( Site 3353)
state: Central Singapore
city: Singapore
country: Singapore
facility: Changi General Hospital ( Site 3356)
state: South East
city: Singapore
country: Singapore
facility: National University Heart Centre, Singapore-Department of Cardiology ( Site 3355)
state: South West
city: Bloemfontein
country: South Africa
facility: Universitas Private Hospital-Cardiology Research ( Site 3453)
state: Free State
city: Johannesburg
country: South Africa
facility: Lenasia Clinical Trial Centre - Johannesburg ( Site 3470)
state: Gauteng
city: Johannesburg
country: South Africa
facility: Netcare Sunninghill Hospital ( Site 3457)
state: Gauteng
city: Midrand
country: South Africa
facility: Midrand Medical Centre ( Site 3466)
state: Gauteng
city: Pretoria West
country: South Africa
facility: Jongaie Research ( Site 3469)
state: Gauteng
city: Pretoria
country: South Africa
facility: University of Pretoria - Faculty of Health Sciences-CRU ( Site 3462)
state: Gauteng
city: Pretoria
country: South Africa
facility: Clinical Trial Systems ( Site 3452)
state: Gauteng
city: Soweto
country: South Africa
facility: Chris Hani Baragwanath Academic Hospital ( Site 3455)
state: Gauteng
city: Durban
country: South Africa
facility: Enhancing Care Foundation ( Site 3456)
state: Kwazulu-Natal
city: Bellville, Cape Town
country: South Africa
facility: Tiervlei Trial Centre ( Site 3461)
state: Western Cape
city: Cape Town
country: South Africa
facility: TREAD Research ( Site 3451)
state: Western Cape
city: Cape Town
country: South Africa
facility: Professor Ntsekhe Cardiology Clinic ( Site 3454)
state: Western Cape
city: George
country: South Africa
facility: Excellentis Clinical Trial Consultants ( Site 3464)
state: Western Cape
city: Paarl
country: South Africa
facility: Paarl Research Centre ( Site 3468)
state: Western Cape
city: Badalona
country: Spain
facility: Hospital Germans Trias i Pujol ( Site 3664)
state: Barcelona
city: Barcelona
country: Spain
facility: Hospital Quiron Barcelona ( Site 3655)
state: Cataluna
city: L'Hospitalet de Llobregat
country: Spain
facility: Hospital Universitari de Bellvitge-Unitat Multidisciplinar d'Insuficiència Cardíaca Comunitària (UM
state: Cataluna
city: A Coruña
country: Spain
facility: CHUAC-Complejo Hospitalario Universitario A Coruña ( Site 3666)
state: La Coruna
city: Santiago de Compostela
country: Spain
facility: CHUS - Hospital Clinico Universitario-Cardiology - Clinical Research Unit ( Site 3651)
state: La Coruna
city: Madrid
country: Spain
facility: Hospital Universitario Ramón y Cajal ( Site 3662)
state: Madrid, Comunidad De
city: Valencia
country: Spain
facility: HOSPITAL CLINICO DE VALENCIA ( Site 3656)
state: Valenciana, Comunitat
city: Barcelona
country: Spain
facility: Parc de Salut Mar - Hospital del Mar ( Site 3663)
city: Barcelona
country: Spain
facility: Hospital Universitari Vall d'Hebron ( Site 3659)
city: Madrid
country: Spain
facility: Hospital Clinico San Carlos-Cardiology ( Site 3661)
city: Madrid
country: Spain
facility: Hospital Universitario La Paz ( Site 3665)
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen de Valme ( Site 3654)
city: Falun
country: Sweden
facility: Falu Lasarett-Dep of Cardiology ( Site 3756)
state: Dalarnas Lan
city: Örebro
country: Sweden
facility: Universitetssjukhuset Örebro-Heart-Lung-Physiology Clinic ( Site 3754)
state: Orebro Lan
city: Lund
country: Sweden
facility: Clemenstorgets Hjartmottagning ( Site 3755)
state: Skane Lan
city: Solna
country: Sweden
facility: Karolinska Universitetssjukhuset Solna-Heart and Vascular theme ( Site 3759)
state: Stockholms Lan
city: Stockholm
country: Sweden
facility: Aleris Specialistvård Sabbatsberg ( Site 3762)
state: Stockholms Lan
city: Stockholm
country: Sweden
facility: Akardo Med Site ( Site 3763)
state: Stockholms Lan
city: Skellefteå
country: Sweden
facility: Skellefteå Lasarett-Research unit, floor 5 ( Site 3760)
state: Vasterbottens Lan
city: Västerås
country: Sweden
facility: Västmanlands Sjukhus Västerås ( Site 3757)
state: Vastmanlands Lan
city: Gothenburg
country: Sweden
facility: Sahlgrenska Universitetssjukhuset-Cardiology Research Unit ( Site 3753)
state: Vastra Gotalands Lan
city: Changhua County
country: Taiwan
facility: Changhua Christian Hospital ( Site 3857)
state: Changhua
city: Hsinchu City
country: Taiwan
facility: Mackay Memorial Hospital-Hsinchu ( Site 3852)
state: Hsinchu
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Medical University Hospital ( Site 3856)
city: Taichung
country: Taiwan
facility: Taichung Veterans General Hospital ( Site 3855)
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hospital-General Clinical Research Center ( Site 3851)
city: Taoyuan
country: Taiwan
facility: Chang Gung Medical Foundation-Linkou Branch ( Site 3854)
city: Bornova
country: Turkey
facility: Ege University Medicine of Faculty-Cardilogy Department ( Site 4054)
state: Izmir
city: Afyonkarahisar
country: Turkey
facility: Afyon Kocatepe Üniversitesi Tıp Fakültesi-Cardiology Department ( Site 4058)
city: Ankara
country: Turkey
facility: Hacettepe Universitesi ( Site 4061)
city: Ankara
country: Turkey
facility: Ankara Bilkent Şehir Hastanesi-cardiology ( Site 4053)
city: Antalya
country: Turkey
facility: Antalya Egitim ve Arastırma Hastanesi-Cardiology ( Site 4064)
city: Eskisehir
country: Turkey
facility: Eskisehir Osmangazi University-Cardiology ( Site 4052)
city: Istanbul
country: Turkey
facility: Istanbul University Cerrahpasa Medical School Internal Diseases Institute-CARDIOLOGY INSTITUTE ( Sit
city: Istanbul
country: Turkey
facility: Başkent Üniversitesi Istanbul Hastanesi ( Site 4057)
city: Istanbul
country: Turkey
facility: Dr. Siyami Ersek Göğüs Kalp Ve Damar Cerrahisi Eğitim Ve Araştırma Hastanesi ( Site 4063)
city: İzmir
country: Turkey
facility: Dokuz Eylül Üniversitesi-CARDIOLOGY ( Site 4055)
city: Izmir
country: Turkey
facility: Medical Park zmir Hastanesi-cardiology ( Site 4059)
city: Kocaeli
country: Turkey
facility: Kocaeli Üniversitesi-Cardiology ( Site 4060)
city: Mersin
country: Turkey
facility: Mersin University ( Site 4056)
city: Cherkasy
country: Ukraine
facility: Communal non-profit enterprise "Cherkasy Regional Hospital of Сherkasy Regional Council" ( Site 4292
state: Cherkaska Oblast
city: Cherkasy
country: Ukraine
facility: Cherkasy Regional Hospital-Cardiorheumatology ( Site 4283)
state: Cherkaska Oblast
city: Ivano-Frankivsk
country: Ukraine
facility: Municipal Non-commercial Enterprise "Ivano-Frankivsk Regional Clinical Cardiology Center of Ivano-Fr
state: Ivano-Frankivska Oblast
city: Івано-Франківськ
country: Ukraine
facility: Clinical medical and diagnostic center Limited Liability Company "Simedgroup" ( Site 4284)
state: Ivano-Frankivska Oblast
city: Kharkiv
country: Ukraine
facility: Central clinical hospital - Ukrzalisnytsia-2nd Cardiology ( Site 4306)
state: Kharkivska Oblast
city: Kharkiv
country: Ukraine
facility: Communal non-profit enterprise "City Clinical Hospital # 27" of Kharkiv City Council ( Site 4262)
state: Kharkivska Oblast
city: Kharkiv
country: Ukraine
facility: L.T. Mala National Institute of Therapy of NAMS of Ukraine-Clinical Pharmacology and Pharmacogeneti
state: Kharkivska Oblast
city: Kharkiv
country: Ukraine
facility: Municipal Non-Profit Enterprise -City clinical hospital No8 of Kharkiv city council ( Site 4278)
state: Kharkivska Oblast
city: Khmelnytskyi
country: Ukraine
facility: Khmelnytskyi Regional Cardiovascular Center-department of invasive cardiology and interventional ra
state: Khmelnytska Oblast
city: Kyiv
country: Ukraine
facility: Medbud Clinic ( Site 4265)
state: Kyivska Oblast
city: Kyiv
country: Ukraine
facility: State Institution National Scientific Center M.D. Strazhesko-Essential Hypertension ( Site 4259)
state: Kyivska Oblast
city: Kiev
country: Ukraine
facility: Kyiv Railway Clinical Hospital No.2 of Branch Health Center of the Public Joint Stock Company Ukrain
state: Kyiv
city: Kiev
country: Ukraine
facility: Medical Center of Limited Liability Company "Medical Center "Consilium Medical" ( Site 4257)
state: Kyiv
city: Odesa
country: Ukraine
facility: Municipal non-profit enterprise'Odesa Regional Clinical Hospital'of Odesa Regional Council ( Site 42
state: Odeska Oblast
city: Vinnytsia
country: Ukraine
facility: Ukrayins'kyy Derzhavnyy Naukovo-Doslidnyy Instytut Rebilitatsiyi Invalidiv ( Site 4274)
state: Vinnytska Oblast
city: Lutsk
country: Ukraine
facility: Lutsk City Clinical Hospital-Center for Cardiovascular Disease ( Site 4255)
state: Volynska Oblast
city: Uzhgorod
country: Ukraine
facility: Zakarpattya Regional Clinical Cardiology Dispensary-Dept. of Hospital Therapy, Uzhhorod National Un
state: Zakarpatska Oblast
city: Zaporizhia
country: Ukraine
facility: Communal Non-profit Enterprise "City Hospital #6" Zaporizhzhia City Counci-Therapy department ( Site
state: Zaporizka Oblast
city: Zaporizhia
country: Ukraine
facility: Communal nonprofit enterprise "City Hospital #9" of Zaporizhzhia City Council ( Site 4251)
state: Zaporizka Oblast
city: Zhytomyr
country: Ukraine
facility: Communal Enterprise "Hospital #1" of Zhytomyr City Council-Advisory and Treatment department of Sci
state: Zhytomyrska Oblast
city: Kyiv
country: Ukraine
facility: Consultative - Diagnostic Centre of Pechersky District-Therapeutic department ( Site 4307)
city: Kyiv
country: Ukraine
facility: MNE " Kyiv City Clinical Emergency Hospital" of Kyiv Regional Council (KCSA) ( Site 4256)
city: Kyiv
country: Ukraine
facility: State Institution National Scientific Center M.D. Strazhesko-Department of clinical arrhythmology a
city: Kyiv
country: Ukraine
facility: State Institution National Scientific Center M.D. Strazhesko-Resuscitation and Intensive care ( Site
city: Carlisle
country: United Kingdom
facility: Cumberland Infirmary ( Site 4174)
state: Cumbria
city: Whitehaven
country: United Kingdom
facility: West Cumberland Hospital ( Site 4176)
state: Cumbria
city: Calow Chesterfield
country: United Kingdom
facility: Chesterfield Royal Hospital ( Site 4159)
state: Derbyshire
city: Dundee
country: United Kingdom
facility: Ninewells Hospital and Medical School-Cardiology ( Site 4164)
state: Dundee City
city: Darlington
country: United Kingdom
facility: Carmel Medical Practice ( Site 4152)
state: England
city: Dudley
country: United Kingdom
facility: Russells Hall Hospital ( Site 4153)
state: England
city: London
country: United Kingdom
facility: King's College Hospital-Cardiac Research Department ( Site 4154)
state: England
city: London
country: United Kingdom
facility: St. George's Hospital-Cardiology Clinical Academic Group ( Site 4156)
state: England
city: Merthyr Tydfil
country: United Kingdom
facility: Prince Charles Hospital ( Site 4171)
state: Great Britain
city: Blackpool
country: United Kingdom
facility: Layton Medical Centre ( Site 4184)
state: Lancashire
city: Belfast
country: United Kingdom
facility: Ulster Hospital ( Site 4185)
state: Lisburn And Castlereagh
city: London
country: United Kingdom
facility: William Harvey Heart Centre ( Site 4169)
state: London, City Of
city: Belfast
country: United Kingdom
facility: Craigavon Area Hospital ( Site 4162)
state: Northern Ireland
city: Bridgend
country: United Kingdom
facility: Princess of Wales Hospital ( Site 4178)
state: Wales
city: West Midlands
country: United Kingdom
facility: Walsall Manor Hospital ( Site 4179)
state: Walsall
city: Worcester
country: United Kingdom
facility: Worcestershire Royal Hospital-Cardiology Research Department ( Site 4181)
state: Worcestershire
city: Blackpool
country: United Kingdom
facility: Blackpool Victoria Hospital ( Site 4161)
city: Coventry
country: United Kingdom
facility: University Hospital Coventry & Warwickshire-Research & Development ( Site 4170)
city: Poole
country: United Kingdom
facility: The Adam Practice ( Site 4180)
city: Stockton-On-Tees
country: United Kingdom
facility: University Hospital of North Tees ( Site 4172)
Study officials:
affiliation: Merck Sharp & Dohme LLC
name: Medical Director
role: STUDY_DIRECTOR
References:
citation: Butler J, Usman MS, Anstrom KJ, Blaustein RO, Bonaca MP, Ezekowitz JA, Freitas C, Lam CSP, Lewis EF, Lindenfeld J, McMullan CJ, Mentz RJ, O'Connor C, Rosano GMC, Saldarriaga CI, Senni M, Udelson J, Voors AA, Zannad F. Soluble guanylate cyclase stimulators in patients with heart failure with reduced ejection fraction across the risk spectrum. Eur J Heart Fail. 2022 Nov;24(11):2029-2036. doi: 10.1002/ejhf.2720. Epub 2022 Nov 16.
citation: Reddy YNV, Butler J, Anstrom KJ, Blaustein RO, Bonaca MP, Corda S, Ezekowitz JA, Lam CSP, Lewis EF, Lindenfeld J, McMullan CJ, Mentz RJ, O'Connor C, Patel M, Ponikowski P, Rosano GMC, Saldarriaga CI, Senni M, Udelson J, Voors AA, Zannad F. Vericiguat Global Study in Participants with Chronic Heart Failure: Design of the VICTOR trial. Eur J Heart Fail. 2025 Feb;27(2):209-218. doi: 10.1002/ejhf.3501. Epub 2024 Oct 30.