Clinical trial NCT04695028: CRYSTALILLE Cohort: Getting the Whole Picture of Crystal-related Arthropathies
Official title: Data Collection for the Constitution of an Observatory for Patients Suffering From Microcrystalline Rheumatism With Morphological Phenotyping
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Gout
Chondrocalcinosis
Hydroxyapatite
Keywords: Gout
Chondrocalcinosis
Hydroxyapatite
Lead sponsor: Lille Catholic University
Sponsor class: OTHER
First posted: 2021-01-05
Enrollment: 1000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Gout Chondrocalcinosis Hydroxyapatite

Brief summary: The objective of this research is to collect data to create an observatory of microcrystalline rheumatism (gout and calcium-crystal rheumatism) in patients treated at the Groupement des Hôpitaux de l'Institut Catholique de Lille, in order to better understand the disease and improve patient care, in particular with the help of medical imaging.

Detailed description: All patients already included in another observational study set up in 2016 and meeting the eligibility criteria may be included in this study. An information letter will be sent to them by mail. If they wish to oppose to the use of their data, they can then return the objection form.

This sample will be supplemented by new patients who are recruited during a classic rheumatology consultation. The investigator will propose the study to all patients meeting the inclusion and non-inclusion criteria.

They will be informed of the objectives of the study and their rights. For patients who agree to participate in the study, sociodemographic and clinical characteristics will be collected.

Depending on the usual care, they will benefit from an ultrasound and/or a dual energy scanner (M0). Imaging data will be collected. Routine clinical follow-up is then carried out in consultation, with collection of clinical and biological evolution data, and morphological data if necessary if imaging is rechecked, until the patient is lost to follow-up or the follow-up is interrupted at the GHICL for any reason.

Available quarterly or semi-annual data will be collected.

Eligibility criteria: Inclusion Criteria:

* Diagnosis of gout according to American College of Rheumatology /European League Against Rheumatism (ACR/EULAR) 2015 criteria OR diagnosis of calcium pyrophosphate dihydrate crystal deposition disease (CPPD) based on EULAR 2011 recommendations OR diagnosis of hydroxyapatite crystal rheumatism (HCR) according to a typical clinical sequence and demonstration of compatible calcium deposits on imaging
* patient who will benefit or has benefited from an ultrasound and/or DECT evaluation of microcrystalline deposits
* clinical suspicion of microcrystalline rheumatism requiring further imaging to confirm the diagnosis

Exclusion Criteria:

* Refusal or contra-indication to perform ultrasound or dual energy scanning.
* Patient's opposition to the use of his or her health data for research purposes
* Patient under guardianship or curatorship
* Pregnant woman
* Person not affiliated to a social security scheme or entitled to a social security benefit

Primary outcomes:
measure: Diagnosis of microcrystalline rheumatism
timeFrame: day 0
measure: Weight
timeFrame: day 0
measure: Height
timeFrame: day 0
measure: Index body mass
timeFrame: day 0
measure: Comorbidities
timeFrame: day 0
measure: Number of rheumatic flares
timeFrame: day 0
measure: Intensity of rheumatic flares
timeFrame: day 0
measure: Identification of subcutaneous tophi
timeFrame: day 0
measure: Uricemia
timeFrame: day 0
measure: Renal function panel
timeFrame: day 0
measure: Lipid profile
timeFrame: day 0
Secondary outcomes:
Other outcomes:
Locations:
city: Lomme
country: France
facility: GHICL- Hôpital Saint Philibert
Study officials:
affiliation: GHICL
name: Tristan Pascart, MD
role: PRINCIPAL_INVESTIGATOR
References: