Clinical trial NCT00015028: Buprenorphine/Naloxone for Opiate-Dependence Treatment - 1
Official title: CS1008A Efficacy/Safety Trial of Buprenorphine/Naloxone
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Opioid-Related Disorders
Substance-Related Disorders
Keywords: opioid dependence
Lead sponsor: National Institute on Drug Abuse (NIDA)
Sponsor class: NIH
Collaborators: name: Cincinnati MDRU
First posted: 2001-04-18
Enrollment: 0
Sex: ALL
Minimum age (years): 23
Maximum age (years): 59
Standard ages: ADULT
Accepts healthy volunteers: no
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine the efficacy and safety of a buprenorphine/naloxone sublingual tablet formulation as an office-based therapy for opiate-dependence treatment. The developmental objective for this combination product is an expansion of therapeutic options for the treatment of opiate dependence.

Detailed description: This multicenter pivotal clinical trial was comprised of two phases. The first phase, which was four weeks in length, was double-blind placebo controlled and was primarily used to evaluate the efficacy of buprenorphine/naloxone. The second phase, lasting 48 weeks, was primarily conducted to determine the safety of buprenorphine/naloxone.

Eligibility criteria: Inclusion Criteria:

1. DSM-IV (Diagnostic and Statistical Manual of the American Psychiatric Association) diagnosis of current opiate dependence.
2. Individuals seeking opiate-substitution pharmacotherapy for opiate dependence.
3. Males and non-pregnant, non-nursing females, 18 to 59 years of age (inclusive).
4. Individuals able to give informed consent and willing to comply with all study procedures (e.g., providing of urine samples under observation, completing questionnaires).

Exclusion Criteria:

1. Any acute or chronic medical condition that would make participation in the study medically hazardous (e.g., acute hepatitis, unstable cardiovascular, hepatic, or renal disease, unstable diabetes, symptomatic AIDS; not HIV-seropositivity alone).
2. Aspartate or alanine aminotransferase (AST, ALT) levels greater than three times the upper limit of normal.
3. Individuals currently taking systemic anti-retroviral or anti-fungal therapy.
4. Current dependence (by DSM-IV criteria) on any psychoactive substance other than opiates, caffeine, or nicotine.
5. Current, primary, Axis I psychiatric diagnosis other than opiate, caffeine, or nicotine dependence.
6. Females of childbearing potential who do not agree to use a medically acceptable method of birth control. Acceptable methods include

   1. oral contraceptive,
   2. barrier (diaphragm or condom) - a spermicide is not required due to the possibility of local irritation and allergic type reactions, but are recommended for use,
   3. levonorgestrel implant,
   4. intrauterine progesterone contraceptive system,
   5. medroxyprogesterone acetate contraceptive injection, or
   6. complete abstinence.
7. Enrollment in an opiate-substitution (i.e., methadone, levo-alpha-acetylmethadol) treatment program within 45 days of enrolling in the present study.
8. Individuals having taken (licitly or illicitly) LAAM, methadone, or naltrexone within days of enrolling in the present study.
9. Individuals having taken buprenorphine, other than as an analgesic, within 365 days of enrolling in the present study.
10. Participation in an investigational drug or device study within 45 days of enrolling in the present study.
11. Anyone, who in the opinion of site principal investigator, would not be expected to complete the first phase of the study protocol (e.g., due to pending incarceration or probable relocation from the clinic area).

Primary outcomes:
measure: Craving
measure: Drug use
measure: HIV risk behaviors
measure: Adverse events
measure: Medical evaluation
Secondary outcomes:
Other outcomes:
Locations:
city: Cincinnati
country: United States
facility: Cincinnati MDRU
state: Ohio
Study officials:
affiliation: Cincinnati MDRU
name: Eugene Somoza, M.D., Ph.D.
role: PRINCIPAL_INVESTIGATOR
References: