Clinical trial NCT06199661: High-Intensity Exercise in Older Adults
Official title: Feasibility and Efficacy of a High-Intensity Exercise Intervention in Elderly Healthy Controls
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Functional Fitness
Cognitive Abilities
Lead sponsor: University of California, Berkeley
Sponsor class: OTHER
Collaborators: name: University of San Francisco
First posted: 2024-01-10
Enrollment: 4
Sex: ALL
Minimum age (years): 50
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The goal of this interventional study was to test the high-intensity interval training called Aphasia Physical Exercise (APEX) in healthy older adults. The main questions it aimed to answer were:

1. what is the safety and feasibility of APEX?
2. what are APEX's acute physiological effects?
3. what is APEX's effects on functional fitness?
4. what is APEX's effects on cognition?

Participants underwent:

* Baseline testing session (#1) with cognitive measures only (a week before the Pre-exercise session);
* Pre-exercise session (#2) with maximum oxygen consumption and heart rate assessment, functional fitness and cognitive measures (3-7 days before the start of the exercise program);
* APEX program, two APEX classes per week for four weeks (eight classes in total);
* Post-exercise session (#3), functional fitness and cognitive measures, (0-2 days after the end of the exercise program).


Eligibility criteria: Inclusion Criteria:

* Between the ages of 50 and 80
* Ambulatory and community-dwelling
* Able to travel to University of San Francisco for weekly exercise classes
* No serious underlying health or neurological conditions

Exclusion Criteria:

* Inability to complete physical function assessment or inability to do a chair stand without using hands
* Use of antidiabetic medications
* Use of testosterone supplement or replacement
* Clinical disorder precluding/interfering with participation or assessments (identified by Physical Activity Readiness Questionnaire (PAR-Q+)), including: unstable angina, arrhythmia, uncontrolled hypertension, end stage renal disease on hemodialysis, lower extremity amputation or paralysis, neurological conditions causing functional or pronounced cognitive impairments, active malignancy except for non-melanomatous skin cancers
* Previous neurological history such as stroke, traumatic brain injury, multiple sclerosis, long-term pre-stroke seizures, Parkinson's, Alzheimer's, etc.
* Unable to provide consent

Primary outcomes:
measure: Attendance Rate
timeFrame: 4 weeks during intervention
measure: Heart Rate
timeFrame: 4 weeks during intervention
measure: Functional Reach Test Distance
timeFrame: Once 3-7 days before start of intervention and once 0-2 days after end of intervention
measure: Timed Up-And-Go Time
timeFrame: Once 3-7 days before start of intervention and once 0-2 days after end of intervention
measure: Number of Steps in 2-minute Step Test
timeFrame: Once 3-7 days before start of intervention and once 0-2 days after end of intervention
measure: Number of Repetitions in 30-Second Chair Stand Test
timeFrame: Once 3-7 days before start of intervention and once 0-2 days after end of intervention
measure: Visual Search Task Accuracy
timeFrame: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
measure: Visual Search Task Reaction Time
timeFrame: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
measure: Forward Digit Span
timeFrame: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
measure: Backward Digit Span
timeFrame: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
measure: Forward Spatial Span
timeFrame: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
measure: Backward Spatial Span
timeFrame: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
measure: Go/No-Go Task Hits
timeFrame: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
measure: Go/No-Go Task Reaction Times
timeFrame: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
measure: Flanker Task Accuracy
timeFrame: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
measure: Flanker Task Reaction Times
timeFrame: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
measure: Stroop Task Accuracy
timeFrame: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
measure: Stroop Task Reaction Times
timeFrame: Once 10-14 days before start of intervention, once 3-7 days before start of intervention, and once 0-2 days after end of intervention
Secondary outcomes:
Other outcomes:
Locations:
city: San Francisco
country: United States
facility: University of San Francisco
state: California
Study officials:
References: