louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04331587: Thin and Ultrathin Bronchoscopy With Transbronchial Needle Aspiration and Radial Probe Endobronchial Ultrasound for Peripheral Pulmonary Lesions
Official title: Evaluation of Thin and Ultrathin Bronchoscopy With Transbronchial Needle Aspiration and Radial Probe Endobronchial Ultrasound for Peripheral Pulmonary Lesions
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Peripheral Pulmonary Nodules
Lead sponsor: Washington University School of Medicine
Sponsor class: OTHER
Collaborators: name: Olympus
First posted: 2020-04-02
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients being seen at Washington University School of Medicine.

Brief summary: To collect data on diagnostic yield of thin and ultrathin bronchoscopes with radial probe endobronchial ultrasound (radial EBUS) and transbronchial needle aspiration (TBNA) during routine standard of care bronchoscopy for peripheral pulmonary lesions.


Eligibility criteria: Inclusion Criteria:

* Patients age 18 and older
* Patients presenting with peripheral pulmonary lesions 1-7cm in greatest diameter on axial CT or PET scan in need of bronchoscopic biopsy for clinical purposes

Exclusion Criteria:

* Patients who are unable to undergo flexible bronchoscopy as determined by the bronchoscopist prior to the procedure
* Patients unwilling or unable to provide informed consent.

Primary outcomes:
measure: Overall diagnostic yield (concentric and eccentric lesions) for peripheral pulmonary nodules
timeFrame: Receipt of cytology/histopathology results (approximately 7 days)
Secondary outcomes:
measure: Incidence of related adverse events
timeFrame: Up to 4 days following procedure
measure: Procedure time measured in minutes from oral scope insertion to scope removal upon completion of the bronchoscopy procedure
timeFrame: From start of procedure through end of procedure (day 1)
measure: Size of target lesions measured at the greatest diameter in centimeters
timeFrame: From start of procedure through end of procedure (day 1)
measure: Diagnostic yield of bronchoscopy utilizing a 3mm bronchoscope for eccentric lesions
timeFrame: Receipt of cytology/histopathology results (approximately 7 days)
measure: Ability to successfully convert ultrasound images from eccentric to concentric view by exchanging the 4mm thin bronchoscope for the 3mm ultrathin bronchoscope
timeFrame: From start of procedure through end of procedure (day 1)
measure: Types of deficiencies associated with medical device
timeFrame: From start of procedure through end of procedure (day 1)
Other outcomes:
Locations:
city: Saint Louis
country: United States
facility: Washington University School of Medicine
state: Missouri
Study officials:
affiliation: Washington University School of Medicine
name: Alexander Chen, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00928954: Cross-over Comparison of Gabapentin and Memantine as Treatment for Acquired Nystagmus
Official title: Investigation and Treatment of Ocular Motor Disorders: Cross-over Comparison of Gabapentin and Memantine as Treatment for Nystagmus
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Nystagmus
Keywords: gabapentin
memantine
nystagmus
Drug treatment
Lead sponsor: Case Western Reserve University
Sponsor class: OTHER
First posted: 2009-06-26
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: Involuntary oscillations of the eyes (nystagmus) impairs vision so that affected patients, who have neurological disorders such as Multiple Sclerosis (MS) , cannot read or watch TV. Two medicines have been reported to suppress nystagmus and improve vision in such patients: gabapentin and memantine. The investigators set out to test which of these two drug was more effective by carrying out a double-blind cross-over study. In this way, we could determine which drug worked best in each patient.

Detailed description: The study entails careful measurements of visual acuity and precise measurements of eye movements, using a contact lens device (magnetic search coil method). In this way, it is possible to make objective and reliable measurements of the effect of each drug, which are unbiased by the investigator or the patient.

Eligibility criteria: Inclusion Criteria:

* Adult (18 years or older) males or females with acquired nystagmus that is degrading their vision

Exclusion Criteria:

* Pregnant women
* Individuals who cannot describe their visual symptoms, cooperate with testing, or give informed consent
* Individuals with intolerance of gabapentin or memantine

Primary outcomes:
measure: Change in logMAR Visual Acuity of Each Eye, Measured During Far or Near Viewing
timeFrame: After 2 weeks of therapy, for both drugs
measure: Percent Change in Median Eye Speed
timeFrame: After 2 weeks of therapy, for both drugs
Secondary outcomes:
Other outcomes:
Locations:
city: Cleveland
country: United States
facility: Veterans Affairs Medical Center, 10701 East Boulevard
state: Ohio
Study officials:
affiliation: Case Western Reserve University
name: Richard J Leigh, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02815254: Better Hips- Better Function
Official title: The Effect of Exercise in Elderly Hip Fracture Patients: a Clinical Randomised Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hip Fracture
Keywords: Physiotherapy
hip fracture
rehabilitation
high dose exercise
low dose exercise
Lead sponsor: Oslo Metropolitan University
Sponsor class: OTHER
Collaborators: name: Braseth rehabilitation centre
First posted: 2016-06-28
Enrollment: 105
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The focus of this project are elderly people who have experienced hip fracture and need at least two weeks rehabilitation after discharge from hospital. The aim is to increase the evidence-based knowledge base for planning and appropriate follow-up intervention for patients with hip fracture on short-term / rehabilitation stays. In this study the investigators want to explore whether training High Intensity Functional Exercises (HIFE) , of short duration ie a 2- 4 week program and frequent intervention ie 5 times per week has a significant positive effect on physical function, pain and quality of life. The main aim is to explore whether a high intensive strength and balance training program has better effect than a low intensive strength and balance training program on functional status measured by Short Physical Performance Battery (SPPB) in patients with hip fractures. Another aims is to explore whether this high intensive strength and balance training program has better effect than a 'low intensive strength and balance training program' on pain, endurance and quality of life measured respectively Numeric Pain Rating Scale (NPR), 6-minute walk test and SF-36. The study is a randomized controlled trial.


Eligibility criteria: Inclusion Criteria:

* Fractura colli femoris, pertrochantar or subtrochantar)
* Discharged from hospital within 3 weeks since surgery.
* Need of minimum two weeks rehabilitation
* Life expectancy of more than one month
* Able to walk at least 3 m with walking aid
* Willingness to participate
* Able to follow instructions
* 65 years or older

Exclusion Criteria:

-Other reasons for gait impairment than hip fracture

Primary outcomes:
measure: The Short Physical Performance Battery
timeFrame: November 2015 -October 2018 (up to 3 years)
Secondary outcomes:
Other outcomes:
Locations:
city: Røyken
country: Norway
facility: Braseth rehabilitation centre
Study officials:
affiliation: Oslo Metropolitan University
name: Astrid Bergland, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Fairhall NJ, Dyer SM, Mak JC, Diong J, Kwok WS, Sherrington C. Interventions for improving mobility after hip fracture surgery in adults. Cochrane Database Syst Rev. 2022 Sep 7;9(9):CD001704. doi: 10.1002/14651858.CD001704.pub5.
Clinical trial NCT02483754: Application and Revision of Montreal Cognitive Assessment in Chinese Retirees
Official title: Application and Revision of Montreal Cognitive Assessment in Military Retirees With Mild Cognitive Impairment
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Mild Cognitive Impairment
Lead sponsor: Xijing Hospital
Sponsor class: OTHER
First posted: 2015-06-29
Enrollment: 304
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Three hundred and four retired military cadres.They can be divided by age, level of education and physical exercise and cerebral apoplexy to evaluate their mild cognitive impairment.

Brief summary: The study was designed to employ MOCA to screen mild cognitive impairment (MCI) in military retirees and to analyze the associated risk factors. As such, MOCA was revised to be validated for the Chinese context.

Detailed description: Three hundred and four retired military cadres were investigated using a random cluster sampling technique including personal information, prevalence, MOCA scale, and related neuropsychiatry scale. Thirty retirees were random chosen and tested again with the revised MOCA scale one month later.

Eligibility criteria: Inclusion Criteria:

* aged \>=60 years old retired military cadres lived in Xian,Shaanxi,China questionnaires completed

Exclusion Criteria:

* deaf-mute

Primary outcomes:
measure: MCI occurrence rate
timeFrame: up to 8 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Air Force Military Medical University, China
name: Xiaoming Wang, Doctor
role: STUDY_CHAIR
References:
Clinical trial NCT04711954: HIV/COV in Ukraine-NL
Official title: COVID-19 in People Living With HIV in Light of the 90-90-90 Goals: A Netherlands/Ukraine Research Collaboration.
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Hiv
Covid19
Lead sponsor: Erasmus Medical Center
Sponsor class: OTHER
Collaborators: name: Lviv Regional AIDS Health Center
First posted: 2021-01-15
Enrollment: 1100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: People with HIV from patient cohorts in the Netherlands and Ukraine. All participants will be systematically included consecutively.

Brief summary: Contradicting preliminary results are available on the impact of COVID-19 in people with HIV (PWH). How achieving goals of the HIV 90-90-90 cascade of care influences the risk of COVID-19 in PWH is unclear. The primary objective is to determine the impact of COVID-19 in PWH cohorts from Ukraine and the Netherlands.


Eligibility criteria: Inclusion Criteria:

HIV infected No registered objection to use of data

Exclusion Criteria:

None

Primary outcomes:
measure: Prevalence COVID19
timeFrame: Up to 2 years
Secondary outcomes:
measure: Incidence COVID-19
timeFrame: Up to 2 years
measure: WHO categories COVID-19
timeFrame: Up to 2 years
measure: WHO categories COVID-19
timeFrame: Up to 2 years
measure: WHO disease severity COVID-19
timeFrame: Up to 2 years
measure: Seroprevalence
timeFrame: Up to 2 years
measure: NPV/PPV WHO categories COVID19
timeFrame: Up to 2 years
measure: Treatment
timeFrame: Up to 2 years
measure: Predictors for COVID-19
timeFrame: Up to 2 years
measure: Predictors for COVID-19 severity
timeFrame: Up to 2 years
Other outcomes:
measure: HIV vs non-HIV
timeFrame: Up to 2 years
measure: PPV/NPV WHO categories COVID-19
timeFrame: Up to 2 years
measure: Effect of socio-economic status by questionnaire on COVID-19 incidence
timeFrame: Up to 2 years
measure: Effect of socio-economic status on COVID-19 severity
timeFrame: Up to 2 years
measure: Symptoms
timeFrame: Up to 2 years
measure: Rapid Ag test
timeFrame: Up to 2 years
Locations:
city: Rotterdam
country: Netherlands
facility: Erasmus MC
city: Lviv
country: Ukraine
facility: Lviv Regional AIDS Health Center
Study officials:
References:
Clinical trial NCT01240954: Comparison of Different Up-dosing Schedules With Osiris
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE2
Conditions: Allergic Rhinitis
Keywords: Rhinitis
Allergic
Immunotherapy
Lead sponsor: ALK-Abelló A/S
Sponsor class: INDUSTRY
First posted: 2010-11-15
Enrollment: 210
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare different up-dosing schedules with Osiris.


Eligibility criteria: Inclusion Criteria:

* history of grass pollen allergy
* Positive SPT to grass
* Positive IgE to grass

Exclusion Criteria:

* uncontrolled and severe asthma

Primary outcomes:
measure: evaluate the tolerability of different up-dosing schedules
timeFrame: 30 days
Secondary outcomes:
measure: patient's satisfaction
timeFrame: 30 days
Other outcomes:
Locations:
city: Kraków
country: Poland
Study officials:
References:
Clinical trial NCT04913454: CLearing Alzheimer's Disease Molecular Pathology Without Medications
Official title: CLearing Alzheimer's Disease Molecular Pathology Without Medications
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Alzheimer Disease
Amyloid Plaque
Amyloidosis
Lead sponsor: University Hospital, Geneva
Sponsor class: OTHER
First posted: 2021-06-04
Enrollment: 20
Sex: ALL
Minimum age (years): 40
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: According to the most popular pathophysiological models of Alzheimer's disease, the amyloid hypothesis, amyloid deposition is the causative event triggering a chain of other downstream events which finally lead to Alzheimer's disease and dementia. In mouse models of Alzheimer's disease, 40 Hz multi-sensory (auditory and visual) stimulation was able to reduce the number and size of amyloid plaques throughout cortex and improve cognitive performance.

The primary objective of this study is to assess whether an intervention consisting of 40 Hz multi-sensory (auditory and visual) stimulation is able to reduce the amyloid load in non-demented amyloid-positive individuals.

As secondary objectives, the investigators will assess whether such intervention is able to:

* improve the brain electrical activity,
* improve or slow down the worsening of Alzheimer's blood-based biomarkers,
* improve or slow down the worsening of cognition.


Eligibility criteria: Inclusion Criteria:

* Informed Consent as documented by signature (Appendix Informed Consent Form),
* age 40-80,
* ≥5 years of education,
* previous evidence of brain amyloidosis (assessed by PET, CSF, or blood-based biomarkers).

Exclusion Criteria:

* history of epilepsy;
* clinically relevant visual or auditory diseases/deficits;
* clinical diagnosis of dementia;
* contraindication to amyloid-PET;
* inability to undergo the procedures of the study, e.g. severe behavioral disturbances;
* severe diseases:

  1. Malignant neoplasm within 5 years,
  2. Life threatening diseases,
  3. Severe systemic diseases (e.g. kidney insufficiency, cardiac insufficiency, decompensated diabetes, decompensated metabolic diseases, decompensated hypothyroidism, uncontrolled autoimmune diseases);
* the participation to a clinical trial involving potential Alzheimer's disease modifying therapies;
* documented pregnancy or intention to become pregnant during the course of the study or breast feeding.

Primary outcomes:
measure: Changes in amyloid load
timeFrame: 8 weeks
Secondary outcomes:
measure: Changes in brain electrical activity
timeFrame: 8 weeks
measure: Changes in Alzheimer's blood-based biomarkers
timeFrame: 8 weeks
measure: Changes in cognition
timeFrame: 8 weeks
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01584154: Comparative Study Between Cryoablation and Radiofrequency Ablation in the Treatment of Supraventricular Tachycardia
Official title: CRYOthermy and Radiofrequency ABLation For AVNRT TrEatment
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Supraventricular Tachycardia
Atrioventricular Nodal Reentrant Tachycardia
Lead sponsor: Princess Margaret Hospital, Hong Kong
Sponsor class: OTHER_GOV
First posted: 2012-04-24
Enrollment: 520
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare the safety and effectiveness of cryoablation and radiofrequency ablation in the treatment of the commonest kind of supraventricular tachycardia, namely atrioventricular nodal reentrant tachycardia. The study hypothesis is that cryoablation is non-inferior to radiofrequency.


Eligibility criteria: Inclusion Criteria:

* Patients who are referred for catheter ablation of supraventricular tachycardia and diagnosis of AVNRT is made by cardiac electrophysiology study

Exclusion Criteria:

1. Patients who aged less than 18 or over 80.
2. Patients who are pregnant.
3. Patients who cannot give informed consent.
4. Patients who are judged to have severe mental impairment and cannot report symptoms of palpitation during follow-up.
5. Patients who had previous AVNRT ablation before.
6. Patients who have comorbid congenital heart disease.

Primary outcomes:
measure: treatment success rate, defined as proportion of treated patients with both atrioventricular block-free acute procedural success and mid-term success without recurrence at 6 months
timeFrame: 6 months after treatment
Secondary outcomes:
measure: Treatment success rate at 12 months
timeFrame: 12 months after treatment
Other outcomes:
Locations:
city: Hong Kong
country: China
facility: Princess Margaret Hospital
state: Guangdong
Study officials:
affiliation: Princess Margaret Hospital, Canada
name: Ngai-Yin Chan, MBBS
role: PRINCIPAL_INVESTIGATOR
References:
citation: Chan NY, Mok NS, Choy CC, Lau CL, Chu PS, Yuen HC, Lau ST. Treatment of atrioventricular nodal re-entrant tachycardia by cryoablation with an 8-mm-tip catheter versus radiofrequency ablation. J Interv Card Electrophysiol. 2012 Sep;34(3):295-301. doi: 10.1007/s10840-012-9670-9. Epub 2012 Mar 9.
citation: Chan NY, Choy CC, Lau CL, Lo YK, Chu PS, Yuen HC, Choi YC, Lau ST. Cryoablation versus radiofrequency ablation for atrioventricular nodal reentrant tachycardia: patient pain perception and operator stress. Pacing Clin Electrophysiol. 2011 Jan;34(1):2-7. doi: 10.1111/j.1540-8159.2010.02858.x. Epub 2010 Aug 18.
citation: Chan NY, Mok NS, Lau CL, Lo YK, Choy CC, Lau ST, Choi YC. Treatment of atrioventricular nodal re-entrant tachycardia by cryoablation with a 6 mm-tip catheter vs. radiofrequency ablation. Europace. 2009 Aug;11(8):1065-70. doi: 10.1093/europace/eup121. Epub 2009 May 17.
Clinical trial NCT04809454: Frequency of Florid Hyperthyroidism In Patients Taking Iodinated Salt
Official title: Frequency of Florid Hyperthyroidism In Patients Taking Iodinated Salt: A Cross Sectional Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Thyroid Dysfunction
Keywords: Thyroid
Iodine
Lead sponsor: Services Institute of Medical Sciences, Pakistan
Sponsor class: OTHER_GOV
First posted: 2021-03-22
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients presenting with biochemical hyperthythyroidism and taking Iodinated salt with age range of 18-60 years

Brief summary: Thyroxin a vital hormone for life lot of body functions depend on proper functioning on pituitary thyroid axis. it exists in two major forms Thyroxine (T4) and (T3) , each of them containing two iodine atoms on their inner (tyrosine) ring. Synthesis of reasonable quantities of thyroid hormones requires adequate iodine intake to allow sufficient thyroidal uptake. The World Health Organization (WHO) recommendation for daily intake of iodine is 150 μg for children ≥12 years and adults, and 250 μg for pregnant and lactating women. However as we know optimum amount of iodine is required for normal pituitary thyroid axis like wise excessive intake may cause over functioning of axis hence over production of hormone that can be manifested both clinically and biochemically.

This study is designed to observe the frequency of over hyperthyroidism in patients taking iodinated salt.

Detailed description: All patients presenting to endocrine clinic fulfilling inclusion and exclusion criteria will be recruited. They will be examined, their vitals including blood pressure pulse will be noted, thyroid clinical examination including eye signs and thyroid status will be done biochemical Thyroid profile (TSH, Free T3 \& Free T4) will be noted in predesigned proforma.

Statistical Analysis will be done ,after data is entered in Statistical Package for the Social Sciences (SPSS) version 25 .qualitative data will be presented as frequencies and percentages while quantitative data will be presented as mean medians and standard deviations.

Eligibility criteria: Inclusion Criteria:

1. All patients presenting with biochemical hyperthyroidism
2. Who are taking Iodinated salt.
3. Treatment naïve patients
4. Both genders included
5. All patients who can give consent (18-60 years)

Exclusion Criteria:

1) Pregnant females 2) Lactating mothers

-

Primary outcomes:
measure: Affect of Iodinated Salt on Thyroid Status
timeFrame: through study completion an average of 12 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Mehwish Iftikhar
state: Punjab
Study officials:
References: