Clinical trial NCT05453032: The Effect of Non Invasive Brain Stimulation on Impulsivity in Borderline Personality Disorder
Official title: Effects of Transcranial Direct Current Stimulation in Conjugation With Psychotherapy on Impulsivity in Patients With Borderline Personality Disorder
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Borderline Personality Disorder
Keywords: impulsivity
Non-Invasive Brain Stimulation
Psychotherapy
Lead sponsor: Ciusss de L'Est de l'Île de Montréal
Sponsor class: OTHER
Collaborators: name: Dr. Lionel Cailhol, chef of psychiatry department at Montreal Psychiatric Institute (IUSMM)
First posted: 2022-07-12
Enrollment: 13
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: we recruited 10 patients who attended a 10-session of tDCS stimulation. Each session lasted for 20 minutes in a 2-week.
Primary purpose: TREATMENT

Brief summary: A pilot study to examine the effects of Non-Invasive Brain stimulation on impulsive behaviour in patients diagnosed with Borderline Personality Disorder. patients who received the neurostimulation sessions will be enrolled in short term psychotherapy (3-month)


Eligibility criteria: Inclusion Criteria

* Clinical Diagnosis of Borderline Personality Disorder (DSM-V)
* Resident of Great Montreal
* Ability to make decision
* Clinical score is equal or more than 17 in Borderline Personality Disorder Severity Index (BPDSI)

resident of greater Montreal Area,

Exclusion Criteria:

* material Metal in the brain
* History of seizure or epilepsy
* severe scalp irritation or eczema
* recent scares, cut wounds, tattoo on the scalp
* severe substance use disorder
* clinical diagnosis of severe mood disorders o
* Active psychotic episode
* Pregnancy

Primary outcomes:
measure: The effect of NIBS on impulsivity (UPPS- Behavioral Impulsive scale)
timeFrame: 2-week stimulation session
Secondary outcomes:
measure: The effect of tDCS on BPD severity overall ( Borderline Personality Disorder Severity Index: BPDSI)
timeFrame: 3 months
measure: The Effect of tDCS on Risk taking ( an impulsive behavior dimension)
timeFrame: 2 weeks
measure: the effect of tDCS on depressive symptoms in BPD (Montgomery-Asberg Depression Rating Scale (MADRS))
timeFrame: 2 weeks
Other outcomes:
Locations:
city: Montréal
country: Canada
facility: Centre Recherche_ Institut Univesitaire de Santé Mentale à Montréal
state: Quebec
Study officials:
References:
citation: Lisoni J, Miotto P, Barlati S, Calza S, Crescini A, Deste G, Sacchetti E, Vita A. Change in core symptoms of borderline personality disorder by tDCS: A pilot study. Psychiatry Res. 2020 Sep;291:113261. doi: 10.1016/j.psychres.2020.113261. Epub 2020 Jun 28.
citation: Lisoni J, Barlati S, Deste G, Ceraso A, Nibbio G, Baldacci G, Vita A. Efficacy and tolerability of Brain Stimulation interventions in Borderline Personality Disorder: state of the art and future perspectives - A systematic review. Prog Neuropsychopharmacol Biol Psychiatry. 2022 Jun 8;116:110537. doi: 10.1016/j.pnpbp.2022.110537. Epub 2022 Feb 15.
citation: Teti Mayer J, Chopard G, Nicolier M, Gabriel D, Masse C, Giustiniani J, Vandel P, Haffen E, Bennabi D. Can transcranial direct current stimulation (tDCS) improve impulsivity in healthy and psychiatric adult populations? A systematic review. Prog Neuropsychopharmacol Biol Psychiatry. 2020 Mar 2;98:109814. doi: 10.1016/j.pnpbp.2019.109814. Epub 2019 Nov 9.