Clinical trial NCT05310071: A Study to Verify the Clinical Benefit of Aducanumab in Participants With Early Alzheimer's Disease
Official title: A Phase 3b/4 Multicenter, Randomized, Double-Blind, Placebo-Controlled, Parallel-Group Study to Verify the Clinical Benefit of Aducanumab (BIIB037) in Participants With Alzheimer's Disease
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE3
Conditions: Alzheimer's Disease
Lead sponsor: Biogen
Sponsor class: INDUSTRY
First posted: 2022-04-04
Enrollment: 1027
Sex: ALL
Minimum age (years): 60
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The primary objective of this study is to verify the clinical benefit of monthly doses of aducanumab in slowing cognitive and functional impairment as measured by changes in the Clinical Dementia Rating Scale Sum of Boxes (CDR-SB) score as compared with placebo in participants with early Alzheimer's disease.


Eligibility criteria: Key Inclusion Criteria:

* The participant must have confirmed amyloid beta pathology by cerebrospinal fluid (CSF) or amyloid PET
* Must have a history of subjective memory decline with gradual onset and slow progression over the 6 months before Screening, confirmed by study partner
* The participant must have 1 informant/care partner who, in the Investigator's opinion, has frequent and sufficient contact with the participant (at least 10 hours/week in person or by phone) as to be able to provide accurate information about the participant's cognitive and functional abilities over time
* Must meet all of the following clinical criteria for MCI due to Alzheimer's disease or mild Alzheimer's disease according to National Institute on Aging and Alzheimer's Association (NIA-AA) criteria

  1. Have an MMSE score between 22 and 30 inclusive
  2. Have a CDR memory score \>0.5
  3. Have a Clinical Dementia Rating Scale Global Score (CDR-GS) of 0.5 or 1.0
  4. Have a Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) score of 85 or lower indicative of objective cognitive impairment
* Apart from a clinical diagnosis of early Alzheimer's disease, the participant must be in good health as determined by the Investigator based on medical history and screening assessments
* Must consent to apolipoprotein E (ApoE) genotyping. (Note: Participants are not required to be ApoE ε4 carriers)

Key Exclusion Criteria:

* Any uncontrolled medical or neurological/neurodegenerative condition (other than Alzheimer's disease) that, in the opinion of the Investigator, might be a contributing cause of the participant's cognitive impairment
* Clinically significant and/or unstable psychiatric illness within 6 months prior to Screening
* Transient ischemic attack or stroke or any unexplained loss of consciousness within 1 year prior to Screening
* History of severe allergic or anaphylactic reactions or of hypersensitivity to any of the inactive ingredients in the drug product
* Participation in any study with purported disease-modifying effect in Alzheimer's disease within 12 months prior to Screening unless documentation of receipt of placebo is available
* Current use or previous use of medications with a purported disease-modifying effect in Alzheimer's disease, outside of investigational studies
* Use of any medications that, in the opinion of the Investigator, may contribute to cognitive impairment, put the participant at higher risk for AEs, or impair the participant's ability to perform cognitive testing or complete study procedures
* Use of any investigational drug
* Prior exposure to aducanumab either commercially or by participation in a previous study with aducanumab. (Participants are eligible if they did not receive active aducanumab.)
* A negative PET scan result with any amyloid-targeting ligand within 12 months prior to Screening

NOTE: Other protocol defined Inclusion/Exclusion criteria may apply

Primary outcomes:
measure: Change From Baseline in Clinical Dementia Rating Scale - Sum of Boxes (CDR-SB) Score at Week 78
timeFrame: Baseline, Week 78
Secondary outcomes:
measure: Change From Baseline in Integrated Alzheimer's Disease Rating Scale (iADRS) Score at Weeks 78 and 106
timeFrame: Baseline, Weeks 78 and 106
measure: Change From Baseline in Alzheimer's Disease Cooperative Study for Activities of Daily Living in Mild Cognitive Impairment (ADCS-ADL-MCI) Scale Score at Weeks 78 and 106
timeFrame: Baseline, Weeks 78 and 106
measure: Change From Baseline in Alzheimer's Disease Assessment Scale, Cognitive Subscale (ADAS-Cog13) at Weeks 78 and 106
timeFrame: Baseline, Weeks 78 and 106
measure: Change From Baseline in Mini-Mental State Examination (MMSE) Scale Score at Weeks 78 and 106
timeFrame: Baseline, Weeks 78 and 106
measure: Change From Baseline in Neuropsychiatric Inventory-10 (NPI-10) Score at Weeks 78 and 106
timeFrame: Baseline, Weeks 78 and 106
measure: Change From Baseline in Amyloid Positron Emission Tomography (PET) Signal at Weeks 78 and 104
timeFrame: Baseline, Weeks 78 and 104
measure: Change From Baseline in Tau PET Signal at Weeks 78 and 104
timeFrame: Baseline, Weeks 78 and 104
measure: Change From Baseline in CDR-SB Score at Week 106
timeFrame: Baseline, Week 106
measure: Change From Baseline in Global Statistical Test (GST) Composite Z-Score at Weeks 78 and 106
timeFrame: Baseline, Weeks 78 and 106
Other outcomes:
Locations:
city: Gilbert
country: United States
facility: Gilbert Neurology Partners, PLLC
state: Arizona
city: Phoenix
country: United States
facility: Xenoscience Inc.
state: Arizona
city: Phoenix
country: United States
facility: Banner Alzheimer's Institute
state: Arizona
city: Phoenix
country: United States
facility: Barrow Neurological Institute
state: Arizona
city: Scottsdale
country: United States
facility: HonorHealth Neurology
state: Arizona
city: Scottsdale
country: United States
facility: Mayo Clinic Arizona
state: Arizona
city: Sun City
country: United States
facility: Banner Sun Health Research Institute
state: Arizona
city: Tucson
country: United States
facility: Banner Alzheimer's Institute
state: Arizona
city: Fayetteville
country: United States
facility: Health Initiatives Research
state: Arkansas
city: El Centro
country: United States
facility: Sun Valley Behaivoral Med Center
state: California
city: Fresno
country: United States
facility: Neuropain Medical Center
state: California
city: Fullerton
country: United States
facility: Neurology Center of North Orange County
state: California
city: Irvine
country: United States
facility: Irvine Center for Clinical Research, Inc.
state: California
city: Los Angeles
country: United States
facility: Mary S. Easton Center for Alzheimer's Disease Research, UCLA
state: California
city: Newport Beach
country: United States
facility: Hoag Memorial Hospital Presbyterian
state: California
city: Palo Alto
country: United States
facility: Stanford Hospital and Clinics
state: California
city: Palo Alto
country: United States
facility: VA Palo Alto Health Care System
state: California
city: Redlands
country: United States
facility: Anderson Clinical Research
state: California
city: San Francisco
country: United States
facility: Sutter Health-San Francisco
state: California
city: San Francisco
country: United States
facility: University of California San Francisco (PARENT)
state: California
city: San Marcos
country: United States
facility: The Neuron Clinic
state: California
city: Santa Ana
country: United States
facility: Syrentis Clinical Research
state: California
city: Sherman Oaks
country: United States
facility: California Neuroscience Research, LLC
state: California
city: Temecula
country: United States
facility: Viking Clinical Research Center
state: California
city: Aurora
country: United States
facility: University of Colorado Anschutz Medical Campus
state: Colorado
city: Basalt
country: United States
facility: Mountain Neurological Research Center
state: Colorado
city: Fairfield
country: United States
facility: Yale University
state: Connecticut
city: New Haven
country: United States
facility: Institute for Neurodegenerative Disorders (IND)
state: Connecticut
city: New Haven
country: United States
facility: Yale University School Of Medicine
state: Connecticut
city: Norwalk
country: United States
facility: Research Center for Clinical Studies, Inc.
state: Connecticut
city: Washington
country: United States
facility: Howard University Health Sciences
state: District of Columbia
city: Altamonte Springs
country: United States
facility: Neurology of Central Florida Research Center, LLC
state: Florida
city: Atlantis
country: United States
facility: JEM Research Institute
state: Florida
city: Boca Raton
country: United States
facility: Neurology Offices of South Florida, PLLC
state: Florida
city: Boca Raton
country: United States
facility: ECommunity Research, LLC
state: Florida
city: Bradenton
country: United States
facility: Nova Clinical Research, LLC
state: Florida
city: Cutler Bay
country: United States
facility: JY Research Institute
state: Florida
city: Delray Beach
country: United States
facility: Brain Matters Research
state: Florida
city: Fort Myers
country: United States
facility: Neuropsychiatric Research Center of Southwest Florida
state: Florida
city: Hollywood
country: United States
facility: Infinity Clinical Research, LLC
state: Florida
city: Lady Lake
country: United States
facility: Charter Research, LLC
state: Florida
city: Lakeland
country: United States
facility: ARS - Lake Oconee
state: Florida
city: Miami
country: United States
facility: Medical Research Center
state: Florida
city: Ocala
country: United States
facility: Renstar Medical Research
state: Florida
city: Ocoee
country: United States
facility: K2 Medical Research, LLC
state: Florida
city: Orlando
country: United States
facility: K2 Medical Research, LLC
state: Florida
city: Orlando
country: United States
facility: K2 Medical Research
state: Florida
city: Orlando
country: United States
facility: Headlands Research LLC
state: Florida
city: Orlando
country: United States
facility: Conquest Research
state: Florida
city: Pompano Beach
country: United States
facility: Quantum Laboratories Inc.
state: Florida
city: Port Orange
country: United States
facility: United Medical Research
state: Florida
city: Stuart
country: United States
facility: Brain Matters Research
state: Florida
city: Tampa
country: United States
facility: K2 Medical Research Tampa
state: Florida
city: Tampa
country: United States
facility: USF Health Byrd Institute
state: Florida
city: Honolulu
country: United States
facility: Hawaii Pacific Neuroscience
state: Hawaii
city: Chicago
country: United States
facility: Great Lakes Clinical Trials, LLC Ravenswood dba Flourish Research
state: Illinois
city: Chicago
country: United States
facility: University of Chicago Medical Center
state: Illinois
city: Elk Grove Village
country: United States
facility: Alexian Brothers Medical Center - Neuroscience Research Institute
state: Illinois
city: Indianapolis
country: United States
facility: Indiana University School of Medicine
state: Indiana
city: Fairway
country: United States
facility: University of Kansas Medical Center Research Institute, Inc.
state: Kansas
city: Wichita
country: United States
facility: Ascension Via Christi Research, a division of Ascension Via Christi Hospitals Wichita, Inc.
state: Kansas
city: Lexington
country: United States
facility: University of Kentucky Medical Center
state: Kentucky
city: New Orleans
country: United States
facility: Ochsner Health System PARENT
state: Louisiana
city: Shreveport
country: United States
facility: LSU Health Sciences Center Shreveport
state: Louisiana
city: Baltimore
country: United States
facility: University of Maryland Medical Center
state: Maryland
city: Belmont
country: United States
facility: McLean Hospital
state: Massachusetts
city: Boston
country: United States
facility: Brigham and Women's Hospital Department of Neurology
state: Massachusetts
city: Boston
country: United States
facility: Beth Israel Deaconess Medical Center
state: Massachusetts
city: Methuen
country: United States
facility: ActivMed Practices and Research
state: Massachusetts
city: Newton
country: United States
facility: Boston Center for Memory
state: Massachusetts
city: Plymouth
country: United States
facility: Donald S. Marks, M.D., P.C.
state: Massachusetts
city: Detroit
country: United States
facility: Wayne State University - Detroit Medical Center
state: Michigan
city: Farmington Hills
country: United States
facility: Michigan Institute for Neurological Disorders
state: Michigan
city: Saint Paul
country: United States
facility: Center for Memory and Aging
state: Minnesota
city: Hattiesburg
country: United States
facility: Hattiesburg Clinic, PA
state: Mississippi
city: Ozark
country: United States
facility: Sharlin Health and Neurology
state: Missouri
city: Omaha
country: United States
facility: University of Nebraska Medical Center
state: Nebraska
city: Las Vegas
country: United States
facility: Cleveland Clinic Lou Ruvo Center for Brain Health
state: Nevada
city: Las Vegas
country: United States
facility: Las Vegas Medical Research
state: Nevada
city: Springfield
country: United States
facility: The Cognitive Research Center of New Jersey
state: New Jersey
city: Toms River
country: United States
facility: CenExel Advanced Memory Research Institute of NJ
state: New Jersey
city: Albany
country: United States
facility: Neurological Associates of Albany, PC
state: New York
city: Amherst
country: United States
facility: Dent Neurologic Institute
state: New York
city: Brooklyn
country: United States
facility: Social Psychiatry Research Institute (SPRI)
state: New York
city: New York
country: United States
facility: New York University Medical Center PRIME
state: New York
city: New York
country: United States
facility: Mount Sinai
state: New York
city: Patchogue
country: United States
facility: South Shore Neurologic Associates, P.C.
state: New York
city: Rochester
country: United States
facility: Finger Lakes Clinical Research
state: New York
city: Rochester
country: United States
facility: University of Rochester - PARENT
state: New York
city: Staten Island
country: United States
facility: Richmond Behavioral Associates ERG Clinical Research - New York PLLC
state: New York
city: Stony Brook
country: United States
facility: Stony Brook University Hospital
state: New York
city: Syracuse
country: United States
facility: SUNY Upstate Medical University
state: New York
city: Tarrytown
country: United States
facility: IMA Evaluations LLC
state: New York
city: Durham
country: United States
facility: Duke University
state: North Carolina
city: Matthews
country: United States
facility: AMC Research, LLC
state: North Carolina
city: Winston-Salem
country: United States
facility: Wake Forest Baptist Health Sciences
state: North Carolina
city: Cleveland
country: United States
facility: Cleveland Clinic Foundation
state: Ohio
city: Columbus
country: United States
facility: Ohio State University Medical Center
state: Ohio
city: North Canton
country: United States
facility: Neuro-Behavioral Clinical Research, Inc.
state: Ohio
city: Oklahoma City
country: United States
facility: Lynn Health Science Institute
state: Oklahoma
city: Tulsa
country: United States
facility: Central States Research, LLC
state: Oklahoma
city: Portland
country: United States
facility: Oregon Health & Science University (OHSU)
state: Oregon
city: Abington
country: United States
facility: Abington Neurological Associates, LTD
state: Pennsylvania
city: Jenkintown
country: United States
facility: The Clinical Trial Center, LLC
state: Pennsylvania
city: Philadelphia
country: United States
facility: Penn Memory Center
state: Pennsylvania
city: East Providence
country: United States
facility: Rhode Island Hospital
state: Rhode Island
city: East Providence
country: United States
facility: Rhode Island Mood & Memory Research Institute
state: Rhode Island
city: Providence
country: United States
facility: Butler Hospital
state: Rhode Island
city: Port Royal
country: United States
facility: Coastal Neurology PA
state: South Carolina
city: Cordova
country: United States
facility: Neurology Clinic, PC
state: Tennessee
city: Knoxville
country: United States
facility: Genesis Neuroscience Clinic
state: Tennessee
city: Austin
country: United States
facility: Senior Adult Specialty Research
state: Texas
city: Brownsville
country: United States
facility: Headlands Research - Brownsville
state: Texas
city: Dallas
country: United States
facility: Kerwin Medical Center
state: Texas
city: Dallas
country: United States
facility: UT Southwestern Medical Center
state: Texas
city: Fort Worth
country: United States
facility: University of North Texas Health Science Center
state: Texas
city: Houston
country: United States
facility: Baylor College Of Medicine
state: Texas
city: Houston
country: United States
facility: The Methodist Hospital Research Institute
state: Texas
city: Houston
country: United States
facility: Clinical Trial Network LLC
state: Texas
city: Round Rock
country: United States
facility: Central Texas Neurology Consultants
state: Texas
city: San Antonio
country: United States
facility: University of Texas Health Science Center at San Antonio
state: Texas
city: Bennington
country: United States
facility: The Memory Clinic
state: Vermont
city: Charlottesville
country: United States
facility: University of Virginia Health System
state: Virginia
city: Norfolk
country: United States
facility: Glennan Center for Geriatrics and Gerontology
state: Virginia
city: Richmond
country: United States
facility: National Clinical Research Inc. - Richmond
state: Virginia
city: Seattle
country: United States
facility: University of Washington Medical Center
state: Washington
city: Spokane
country: United States
facility: Kingfisher Cooperative, LLC
state: Washington
city: Madison
country: United States
facility: University of Wisconsin-Madison
state: Wisconsin
city: Marshfield
country: United States
facility: Marshfield Clinic
state: Wisconsin
city: Milwaukee
country: United States
facility: Medical College of Wisconsin, Inc.
state: Wisconsin
city: Darlinghurst
country: Australia
facility: St Vincent's Hospital Sydney
state: New South Wales
city: Macquarie Park
country: Australia
facility: KaRa Institute of Neurological Diseases
state: New South Wales
city: Box Hill
country: Australia
facility: Box Hill Hospital
state: Victoria
city: Frankston
country: Australia
facility: Frankston Hospital
state: Victoria
city: Heidelberg
country: Australia
facility: Austin Health
state: Victoria
city: Melbourne
country: Australia
facility: The Alfred Hospital
state: Victoria
city: Parkville
country: Australia
facility: Royal Melbourne Hospital
state: Victoria
city: Nedlands
country: Australia
facility: Australian Alzheimer's Research Foundation
state: Western Australia
city: Leuven
country: Belgium
facility: UZ Leuven
state: Flemish Brabant
city: Brugge
country: Belgium
facility: AZ Sint-Jan
city: Brussel
country: Belgium
facility: Universitair Ziekenhuis Brussel
city: Kortrijk
country: Belgium
facility: AZ Groeninge
city: Curitiba
country: Brazil
facility: Trial Tech Tecnologia em Pesquisas com Medicamentos Ltda
state: Paraná
city: Curitiba
country: Brazil
facility: Instituto de Neurologia de Curitiba - Hospital Ecoville
state: Paraná
city: Porto Alegre
country: Brazil
facility: IMV Pesquisa Neurologica Sociedade Simples Ltda
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Instituto do Cerebro do Rio Grande do Sul
state: Rio Grande Do Sul
city: São Paulo
country: Brazil
facility: IPq-HCFMUSP - Instituto de Psiquiatria do Hospital das Clínicas da FMUSP
state: Sao Paulo
city: Calgary
country: Canada
facility: University of Calgary - Heritage Medical Research Clinic
state: Alberta
city: Vancouver
country: Canada
facility: UBC Hospital
state: British Columbia
city: Halifax
country: Canada
facility: Centricity Research Halifax
state: Nova Scotia
city: Ottawa
country: Canada
facility: Recherches Neuro-Hippocampe Inc., d/b/a Ottawa Memory Clinic
state: Ontario
city: Peterborough
country: Canada
facility: Kawartha Centre - Redefining Healthy Aging
state: Ontario
city: Toronto
country: Canada
facility: Toronto Memory Program (Neurology Research Inc.)
state: Ontario
city: Toronto
country: Canada
facility: Centricity Research Toronto LMC
state: Ontario
city: Toronto
country: Canada
facility: Sunnybrook Health Sciences Centre
state: Ontario
city: Toronto
country: Canada
facility: Toronto Western Hospital
state: Ontario
city: Toronto
country: Canada
facility: Baycrest Centre for Geriatric Care
state: Ontario
city: Gatineau
country: Canada
facility: Clinique de la Memoire de l'Outaouais
state: Quebec
city: Greenfield-Park
country: Canada
facility: MoCA Research and Innovation Inc
state: Quebec
city: Montréal
country: Canada
facility: Montreal Neurological Institute Clinical Research Unit
state: Quebec
city: Quebec
country: Canada
facility: CHU de Quebec- Hopital de l Enfant Jesus
city: Helsinki
country: Finland
facility: Terveystalo Ruoholahti
city: Turku
country: Finland
facility: CRST, Clinical Research Services Turku
city: Strasbourg Cedex
country: France
facility: CHU Strasbourg - Hôpital Hautepierre
state: Bas Rhin
city: Marseille cedex 05
country: France
facility: Hôpital de la Timone
state: Bouches-du-Rhône
city: Bordeaux Cedex
country: France
facility: Groupe Hospitalier Pellegrin - Hôpital Pellegrin
state: Gironde
city: Toulouse Cedex 9
country: France
facility: Hôpital La Grave
state: Haute Garonne
city: Montpellier
country: France
facility: Hopital Gui de Chauliac
state: Herault
city: Rennes cedex 9
country: France
facility: CHU Rennes - Pontchaillou
state: Ille Et Vilaine
city: Saint-Herblain
country: France
facility: CHU Nantes - Hopital Nord Laënnec
state: Loire Atlantique
city: Lille Cedex
country: France
facility: Hopital Roger Salengro - CHU Lille
state: Nord
city: Paris cedex 10
country: France
facility: Hôpital Lariboisière
state: Paris
city: Villeurbanne
country: France
facility: Hôpital des Chapennes
state: Rhone
city: Paris
country: France
facility: Groupe Hospitalier Pitie-Salpetriere
city: Paris
country: France
facility: Hôpital Broca
city: Freiburg
country: Germany
facility: Universitaetsklinikum Freiburg
state: Baden Wuerttemberg
city: Mannheim
country: Germany
facility: ISPG - Institut fuer Studien zur Psychischen Gesundheit
state: Baden Wuerttemberg
city: Tuebingen
country: Germany
facility: Universitaetsklinikum Tuebingen
state: Baden Wuerttemberg
city: Bayreuth
country: Germany
facility: Klinikum Bayreuth GmbH- Hohe Warte
state: Bayern
city: Muenchen
country: Germany
facility: Institut fuer Schlaganfall- und Demenzforschung (ISD)
state: Bayern
city: Muenchen
country: Germany
facility: Klinikum rechts der Isar der TU Muenchen
state: Bayern
city: Bad Homburg
country: Germany
facility: Zentrum für klinische Forschung Dr.med. Irma Schöll
state: Hessen
city: Frankfurt
country: Germany
facility: Universitaetsklinikum Frankfurt Goethe-Universitaet
state: Hessen
city: Greifswald
country: Germany
facility: Universitaetsmedizin Greifswald
state: Mecklenburg Vorpommern
city: Goettingen
country: Germany
facility: Universitaetsmedizin Goettingen
state: Niedersachsen
city: Bochum
country: Germany
facility: Katholisches Klinikum Bochum gGmbH
state: Nordrhein Westfalen
city: Bonn
country: Germany
facility: Deutsches Zentrum fuer Neurodegenerative Erkrankungen (DZNE)
state: Nordrhein Westfalen
city: Duesseldorf
country: Germany
facility: Universitaetsklinikum Duesseldorf AoeR
state: Nordrhein Westfalen
city: Koeln
country: Germany
facility: Universitaetsklinikum Koeln
state: Nordrhein Westfalen
city: Magdeburg
country: Germany
facility: Universitaetsklinikum Magdeburg
state: Sachsen Anhalt
city: Dresden
country: Germany
facility: Universitaetsklinikum Carl Gustav Carus TU Dresden
state: Sachsen
city: Berlin
country: Germany
facility: NEUROZENTRUM tempelhof.berlin
city: Berlin
country: Germany
facility: Charité - Universitätsmedizin Berlin
city: Tricase
country: Italy
facility: Azienda Ospedaliera Card. G. Panico
state: Lecce
city: Monza
country: Italy
facility: ASST di Monza
state: Milano
city: Cefalù
country: Italy
facility: Fondazione Istituto G.Giglio di Cefalù
state: Palermo
city: Arzignano VI
country: Italy
facility: Ospedale di Arzignano
state: Vicenza
city: Brescia
country: Italy
facility: Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (Presidio Spedali Civili)
city: Genova
country: Italy
facility: IRCCS Ospedale Policlinico San Martino
city: Milano
country: Italy
facility: Ospedale San Raffaele
city: Napoli
country: Italy
facility: Azienda Ospedaliera Universitaria- Università degli Studi della Campania "Luigi Vanvitelli"
city: Perugia
country: Italy
facility: Azienda Ospedaliera e Universitaria di Perugia
city: Roma
country: Italy
facility: Fondazione Santa Lucia IRCCS
city: Roma
country: Italy
facility: Azienda Ospedaliera Universitaria Policlinico Umberto I - Università di Roma La Sapienza
city: Salerno
country: Italy
facility: Azienda Ospedaliera Universitaria OO. RR. S. Giovanni di Dio e Ruggi D'Aragona
city: Obu-shi
country: Japan
facility: National Center For Geriatrics And Gerontology
state: Aichi-Ken
city: Chiba-shi
country: Japan
facility: Hakuyokai Kashiwado Hospital
state: Chiba-Ken
city: Chiba-shi
country: Japan
facility: Inage Neurology and Memory Clinic
state: Chiba-Ken
city: Koriyama-shi
country: Japan
facility: Southern Tohoku Medical Clinic
state: Fukushima-Ken
city: Otake-shi
country: Japan
facility: NHO Hiroshima-Nishi Medical Center
state: Hiroshima-Ken
city: Himeji-shi
country: Japan
facility: Himeji Central Hospital Clinic
state: Hyogo-Ken
city: Kita-gun
country: Japan
facility: Kagawa University Hospital
state: Kagawa-Ken
city: Atsugi-shi
country: Japan
facility: Tokushukai Shonan Atsugi Hospital
state: Kanagawa-Ken
city: Kamakura-shi
country: Japan
facility: Tokushukai Shonan Kamakura General Hospital
state: Kanagawa-Ken
city: Kawasaki-shi
country: Japan
facility: Teikyo University Hospital, Mizonokuchi
state: Kanagawa-Ken
city: Kyoto-shi
country: Japan
facility: Rakuwakai Otowa Rehabilitation Hospital
state: Kyoto-Fu
city: Kyoto-shi
country: Japan
facility: NHO Utano National Hospital
state: Kyoto-Fu
city: Kurashiki-shi
country: Japan
facility: Katayama Medical Clinic
state: Okayama-Ken
city: Kishiwada-shi
country: Japan
facility: Tokushukai Kishiwada Tokushukai Hospital
state: Osaka-Fu
city: Suita-shi
country: Japan
facility: Osaka University Hospital
state: Osaka-Fu
city: Kasukabe-shi
country: Japan
facility: Midorikai Takesato Hospital
state: Saitama-Ken
city: Bunkyo-ku
country: Japan
facility: Memory Clinic Ochanomizu
state: Tokyo-To
city: Kodaira-shi
country: Japan
facility: National Center of Neurology and Psychiatry
state: Tokyo-To
city: Yamagata-shi
country: Japan
facility: Tokushukai Yamagata Tokushukai Hospital
state: Yamagata-Ken
city: Seongnam
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
state: Gyeonggi-do
city: Seoul
country: Korea, Republic of
facility: Konkuk University Medical Center
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center
city: Ciudad de México
country: Mexico
facility: Health Pharma Professional Research S.A. de C.V.
state: Distrito Federal
city: Guadalara
country: Mexico
facility: Hospital Mexico Americano SC
state: Jalisco
city: Monterrey
country: Mexico
facility: Hospital Universitario Dr. Jose Eleuterio Gonzalez
state: Nuevo León
city: Monterrey
country: Mexico
facility: Centro de Estudios Clinicos y Especialidades Medicas, S.C.
state: Nuevo León
city: Monterrey
country: Mexico
facility: AVIX Investigación Clínica S.C
state: Nuevo León
city: Bydgoszcz
country: Poland
facility: PROMENTE Sp. z o.o.
state: Kujawsko-Pomorskie Województwo
city: Warszawa
country: Poland
facility: Centrum Medyczne NeuroProtect
state: Mazowieckie Województwo
city: Bialystok
country: Poland
facility: Podlaskie Centrum Psychogeriatrii
state: Podkarpackie Wojewódctwo
city: Sopot
country: Poland
facility: Centrum Medyczne Senior
state: Pomorskie Województwo
city: Lublin
country: Poland
facility: Samodzielny Publiczny Szpital Kliniczny Nr 4 w Lublinie Kliniczny Oddział Neurologii Oddział Udarowy
city: Wroclaw
country: Poland
facility: NZOZ Wroclawskie Centrum Alzheimerowskie
city: Katowice
country: Poland
facility: Nzoz Novo-Med
state: Śląskie Województwo
city: Siemianowice Slaskie
country: Poland
facility: Neuro-Care Gabriela Klodowska
state: Śląskie Województwo
city: Cordoba
country: Spain
facility: Hospital Universitario Reina Sofia
state: Córdoba
city: San Sebastian
country: Spain
facility: Policlinica Gipuzkoa
state: Guipuzcoa
city: Pamplona
country: Spain
facility: Clinica Universidad de Navarra
state: Navarra
city: Barcelona
country: Spain
facility: Fundacio ACE
city: Barcelona
country: Spain
facility: Hospital Clinic de Barcelona
city: Barcelona
country: Spain
facility: Hospital de la Santa Creu i Sant Pau
city: Lleida
country: Spain
facility: Hospital Universitari de Santa Maria
city: Madrid
country: Spain
facility: Clinica Universidad de Navarra (MAD)
city: Sevilla
country: Spain
facility: Hospital Victoria Eugenia
city: Valencia
country: Spain
facility: Hospital Universitario Dr. Peset
city: Valencia
country: Spain
facility: Hospital Universitari i Politecnic La Fe
city: Malmö
country: Sweden
facility: Skane University Hospital
state: Scania
city: Mölndal
country: Sweden
facility: Sahlgrenska Universitetssjukhuset, Mölndal Sjukhus
state: Västra Götaland
city: Stockholm
country: Sweden
facility: Karolinska Universitetssjukhuset
city: Edinburgh
country: United Kingdom
facility: The University of Edinburgh
state: East Lothian
city: London
country: United Kingdom
facility: Institute of Psychiatry, Psychology and Neuroscience
state: Greater London
city: London
country: United Kingdom
facility: Re:Cognition Health Ltd (London)
state: Greater London
city: London
country: United Kingdom
facility: Charing Cross Hospital
state: Greater London
city: Manchester
country: United Kingdom
facility: Park House
state: Greater Manchester
city: Southampton
country: United Kingdom
facility: Southampton General Hospital
state: Hampshire
city: Southampton
country: United Kingdom
facility: Moorgreen Hospital
state: Hampshire
city: Edinburgh
country: United Kingdom
facility: Brain Health Scotland Life Sciences
state: Lothian Region
city: Bath
country: United Kingdom
facility: The RICE Centre
state: Somerset
city: Motherwell
country: United Kingdom
facility: Glasgow Memory Clinic Ltd
state: Strathclyde
city: Bristol
country: United Kingdom
facility: Re Cognition Health Bristol
Study officials:
affiliation: Biogen
name: Medical Director
role: STUDY_DIRECTOR
References: