Clinical trial NCT06998771: JSKN003 Combined Treatment of HER2-positive Gastric Cancer
Official title: A Phase II Trial to Evaluate the Safety and Efficacy of JSKN003 Combination Therapy as First-line Treatment in HER2-positive Unresectable Locally Advanced or Metastatic Gastric Cancer or Resectable Gastric Cancer
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: PHASE2
Conditions: HER2-positive Gastric Cancer
Lead sponsor: Shanghai JMT-Bio Inc.
Sponsor class: INDUSTRY
First posted: 2025-05-31
Enrollment: 153
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study is designed to evaluate the safety and efficacy of JSKN003 combination therapy as first-line treatment in HER2-positive unresectable locally advanced or metastatic gastric cancer or resectable gastric cancer.


Eligibility criteria: Inclusion Criteria:

* Age≥18 years old.
* Histologically or cytologically confirmed diagnosis of gastric cancer.
* The first-line population enrolls participants with HER2-positive unresectable locally advanced or metastatic gastric cancer who had not received systemic treatment, and Perioperative population enrolls participants with HER2-positive resectable gastric cancer who had not received treatment.
* HER2-positive (defined as IHC3+ or IHC 2+/FISH +).
* The first-line population: presence of at least 1 measurable lesion per RECIST 1.1. Tumor lesions situated in a previously irradiated area are considered measurable if progression has been demonstrated in such lesions.
* ECOG PS of 0 - 1.
* Expected survival ≥ 3 months.
* Participants with adequate organ functions.
* Female and male patients of childbearing age agree to take adequate contraceptive measures during and upon completion of the study for 7 months after the last dose. Female participants of childbearing age must have a negative blood pregnancy test within 7 days before the first dose or randomization.
* Voluntarily agree to participate in the study and sign the informed consent.

Exclusion Criteria:

* Has received anti-tumor treatment such as systemic chemotherapy or other trial interventions within 28 days, or immunotherapy (e.g. interleukin, interferon, thymospipeptide, etc.), hormone therapy or targeted therapy within 14 days or 5 half-life (whichever is shorter) before the first dose or randomization.
* Has previously been treated with an anti-HER2 ADC loaded with topoisomerase I inhibitors.
* Participants with brain metastasis or spinal cord compression at screening (except for completed local treatment and discontinued glucocorticoids for at least 4 weeks before the first dose or randomization , and stable central nervous system imaging and brain metastasis symptoms for at least 4 weeks).
* Participants with PD-L1 CPS ≥1, who are receiving long-term immunotherapy (e.g., cyclosporine) or require daily systemic steroid therapy (e.g., \>20 mg prednisone or equivalent), except those who treated with local glucocorticoids using nasal spray, inhalation, or other pathways.
* Participants with PD-L1CPS ≥1, who have an active autoimmune disease or have a history of autoimmune disease 2 years before the first dose or randomization and still require systemic treatment. However, participant with the following diseases is allowed to enroll: well-controlled type I diabetes, well-controlled hypothyroidism that requires hormone replacement therapy, skin diseases that do not require systemic treatment (such as vitiligo, psoriasis, or hair loss), or participant who is expected to not recur without external triggers.
* Participate in another clinical trial, unless it is an observational (non-intervention) clinical trial or is in the follow-up period of an intervention trial.
* Participants who have undergone major surgery or had invasive intervention within 28 days before the first dose or randomization. Or those who plan to undergo systematic or local tumor resection during the trial (Perioperative cohort does not apply).
* Any Chinese patent medicine with anti-cancer activity approved by the National Drug Administration (regardless of cancer type) has been used within 14 days before the first dose or randomization.
* Has a history of severe hypersensitivity reactions to either the drug substances or inactive ingredients in the drug product.
* Active bacterial, fungal or viral infection before the first dose or randomization. Participant who has recieved preventive infection treatment but has no clinical manifestations before the first dose or randomization could be considered to enroll.
* Has a history of immunodeficiency, including HIV-positive.
* Active hepatitis B or C infection. Participant with positive hepatitis B surface antigen (HBsAg) or hepatitis B core antibody (HBcAb) need to test Hepatitis B virus DeoxyriboNucleic Acid (HBV-DNA), and HBV-DNA is higher than 500 IU/mL (or 2500 copies/ml) or upper limit of normal (UNL) (whichever is lower) ; Participants with positive for hepatitis C (HCV) antibody and whose Hepatitis C virus Ribonucleic Acid (HCV-RNA) is higher than 1000 copies/ml or UNL (whichever is lower).
* Has a history of tuberculosis treatment within 2 years before the first dose or randomization.
* Has activity or a history of interstitial lung disease at any stage and/or pulmonary function injury, a history of interstitial pneumonia requiring hormone therapy, or the imaging cannot rule out suspected interstitial lung disease/pneumonia at screening.
* Known to have low activity or lack of dihydropyrimidine dehydrogenase (DPD).
* Participants with peripheral neuropathy of grade \> 1.
* Participants with clinically significant gastrointestinal diseases including but not limited to severe liver diseases, ulcerative colitis, inflammatory bowel disease and other gastrointestinal diseases 28 days before the first dose or randomization.
* Has a history of severe cardiovascular disease.
* History of any other malignant tumors within 5 years before the first dose or randomization.
* Live vaccination within 28 days before the first dose or randomization. Note: Seasonal influenza vaccine is a broadly inactivated vaccine and is allowed to be used;
* Unable to swallow orally, or there are conditions that have been judged by researchers to seriously affect gastrointestinal absorption (such as severe Crohn's disease, malabsorption syndrome, etc.).
* Pregnant or breastfeeding women.
* Otherwise considered inappropriate for the study by the investigator.

Primary outcomes:
measure: Objective Response Rate (ORR) of the first-line population
timeFrame: Frame: Up to approximately 5 years
measure: Incidence and severity of TEAE and SAE of the first-line population
timeFrame: Up to approximately 5 years
measure: pCR rate after neoadjuvant therapy of perioperative population
timeFrame: Up to approximately 5 years
Secondary outcomes:
measure: Disease Control Rate (DCR) of the first-line population
timeFrame: Up to approximately 5 years
measure: Duration of Response (DoR) of the first-line population
timeFrame: Up to approximately 5 years
measure: Progression-free survival (PFS) of the first-line populations
timeFrame: Up to approximately 5 years
measure: Major pathological response (MPR) rate of perioperative population
timeFrame: Up to approximately 5 years
measure: R0 rate of perioperative population
timeFrame: Up to approximately 5 years
measure: Event-free survival (EFS) of perioperative population
timeFrame: Up to approximately 5 years
measure: Overall Survival (OS)
timeFrame: Up to approximately 5 years
measure: Incidence and severity of AE
timeFrame: Up to approximately 5 years
measure: Blood concentration of JSKN003
timeFrame: Up to approximately 2 years
measure: Blood concentration of total antibodies for JSKN003
timeFrame: Up to approximately 2 years
measure: Blood concentration of free toxins for JSKN003
timeFrame: Up to approximately 2 years
measure: Serum concentration of KN026
timeFrame: Up to approximately 2 years
measure: Serum concentration of Enlonstobart;
timeFrame: Up to approximately 2 years
measure: Anti-drug antibodies (ADA) related to JSKN003
timeFrame: Up to approximately 2 years
measure: Title: ADA related to KN026
timeFrame: Up to approximately 2 years
measure: ADA related to Enlonstobart
timeFrame: Up to approximately 2 years
Other outcomes:
Locations:
Study officials:
References: