Clinical trial NCT04950205: Influence of Postoperative Cognitive Function in Patients With Sevoflurane Postconditioning on Carotid Intima Stripped
Official title: The Influence of Postoperative Cognitive Function in Patients With Sevoflurane Postconditioning on Carotid Intima Stripped
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: EARLY_PHASE1
Conditions: Postoperative Cognitive Dysfunction
Sevoflurane
Carotid Artery Intima Stripped
Lead sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
Sponsor class: OTHER
First posted: 2021-07-06
Enrollment: 140
Sex: ALL
Minimum age (years): 50
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: Brief summary: In order to get a better clinical plan for brain protection during perioperative anesthesia for high-risk patients - carotid intima stripped. We observing the hemodynamic changes of sevoflurane post-treatment in carotid intima stripped, the comparison of postoperative cognitive function and postoperative radiographic changes.


Eligibility criteria: Inclusion Criteria:

* American Society of Anesthesiologists（ASA）：II-III
* Aged between 40 and 80 years
* Patients scheduled for surgery of Carotid stenosis under general anaesthesia

Exclusion Criteria:

* Has a history of mental illness can't cooperate,
* Serious heart block or cardiac decompensation or severe sinus slow (HR \< 50 times/min),
* The abnormal nerve monitoring in operation, MMES preoperative score \< 20 points,
* Any rescue unexpected occurred during the operation

Primary outcomes:
measure: Change from the 1 day preoperative to the 1 day postoperative MMSE(Mini-mental State Examination)
timeFrame: the 1st day before the surgery；the 1st day after the surgery
measure: Change from the 1 day preoperative to the 1 day postoperative MoCA(Montreal Cognitive Assessment)
timeFrame: Time Frame: the 1st day before the surgery；the 1st day after the surgery
Secondary outcomes:
measure: Heart rate
timeFrame: Ten minutes before induction（T0) ,Intraoperative (Before the carotid artery occlusion（T1）), Intraoperative (before open the Carotid artery（T2)，At the end of the surgery when the surgeon completed sewing skin（T3），the 24 hours after the operation（T4）
measure: Invasive arterial blood pressure
timeFrame: Ten minutes before induction（T0) ,Intraoperative (Before the carotid artery occlusion（T1）), Intraoperative (before open the Carotid artery（T2)，At the end of the surgery when the surgeon completed sewing skin（T3），the 24 hours after the operation（T4）
measure: BIS
timeFrame: Ten minutes before induction（T0) ,Intraoperative (Before the carotid artery occlusion（T1）), Intraoperative (before open the Carotid artery（T2)，At the end of the surgery when the surgeon completed sewing skin（T3），the 24 hours after the operation（T4）
measure: PETCO2
timeFrame: Ten minutes before induction（T0) ,Intraoperative (Before the carotid artery occlusion（T1）), Intraoperative (before open the Carotid artery（T2)，At the end of the surgery when the surgeon completed sewing skin（T3），the 24 hours after the operation（T4）
measure: Cerebral oxygen saturation
timeFrame: Ten minutes before induction（T0) ,Intraoperative (Before the carotid artery occlusion（T1）), Intraoperative (before open the Carotid artery（T2)，At the end of the surgery when the surgeon completed sewing skin（T3），the 24 hours after the operation（T4）
Other outcomes:
Locations:
city: HangZhou
country: China
facility: 2nd Affiliated Hospital, School of Medicine, Zhejiang University
state: Zhejiang
city: HangZhou
country: China
facility: 2nd Affiliated Hospital, School of Medicine, Zhejiang University
state: Zhejiang
Study officials:
References: