Clinical trial NCT02297633: Evaluation of Reactive Oxygen Metabolites in the Value of COPD
Official title: System Evaluation of Reactive Oxygen Metabolites in the Value of Chronic Obstructive Pulmonary Disease
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: COPD(Chronic Obstructive Pulmonary Disease)
Keywords: COPD
reactive oxygen metabolites
Lead sponsor: Beijing Chao Yang Hospital
Sponsor class: OTHER
First posted: 2014-11-21
Enrollment: 320
Sex: ALL
Minimum age (years): 40
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Chaoyang hospital clinic

Brief summary: This study through the long-term observation followed up for 2 years to find the change of the COPD patients blood ROMs, systematically evaluate the relationship between ROMs and the severity of COPD. Evaluate the differences of prognosis between the different oxidative stress level (according to the level of ROMs are divided into higher and normal phenotype). Explore the new oxidative stress evaluation index ROMs application value in COPD.

Detailed description: Reactive oxygen metabolites (reactive oxygen metabolites, ROMs) test is a method by measuring the total reactive oxygen metabolites (ROMs) content in blood so as to evaluate the overall level of oxidative stress in the human body .Our previous studies have established the method of detecting ROMs which is suitable for fully automatic biochemical analyser.Our study through the long-term observation followed up for 2 years to find the change of the COPD patients blood ROMs, systematically evaluate the relationship between ROMs and the severity of COPD. Evaluate the differences of prognosis between the different oxidative stress level (according to the level of ROMs are divided into higher and normal phenotype). Explore the new oxidative stress evaluation index ROMs application value in COPD.

Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of COPD according to GOLD 2013

Exclusion Criteria:

* A history of asthma or other chronic lung diseases Take Antioxidant therapy There are new or recurrent symptomatic myocardial ischemia, severe arrhythmia, cardiac insufficiency cerebrovascular disease Senile dementia or cognitive impairment cancer Severe liver and kidney and other viscera function insufficiency Language communication barriers Limb activity disorder The last 3 months participated in sports training

Primary outcomes:
measure: The different levels of the ROMs among different groups
timeFrame: 3 years
Secondary outcomes:
measure: The differences of the ROMs among the different lung function levels in the stable stage of COPD group
timeFrame: 3 years
measure: The relevance of the ROMs with the lung function levels in the stable stage of COPD group
timeFrame: 3 years
measure: The relevance of the ROMs with the score of mMRC in the stable stage of COPD group
timeFrame: 3 years
measure: The relevance of the ROMs with the score of CAT in the stable stage of COPD group
timeFrame: 3 years
measure: The relevance of the ROMs with the numbers of exacerbation in the stable stage of COPD group
timeFrame: 3 years
Other outcomes:
Locations:
city: Beijing
country: China
facility: Respiratory Institute;Beijing chaoyang hospital
state: Beijing
Study officials:
affiliation: Respiratory Institute, Beijing chaoyang hospital
name: Ting Yang, Doctor
role: STUDY_DIRECTOR
References: