louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06265571: Postoperative Pain in Shoulder Surgery
Official title: The Effect of Ultrasound-Guided Suprascapular Block Plus Low-dose Interscalen Brachial Plexus Block for Postoperative Pain in Shoulder Surgery
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pain, Postoperative
Lead sponsor: Eskisehir Osmangazi University
Sponsor class: OTHER
First posted: 2024-02-20
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: \>18 years old patients undergoing arthroscopic shoulder surgery by the same surgeon.

Brief summary: After the approval of the ethics committee, the files of the patients who underwent arthroscopic shoulder surgery between 01.01.2019 and 01.03.2020 were evaluated retrospectively.

Data were recorded including age, gender, duration of anesthesia, duration of surgery, postoperative analgesia consumption, complications such as respiratory distress due to hemidiaphragmatic paralysis and complications such as hematoma and nerve damage due to block intervention.

Detailed description: Patients who underwent arthroscopic shoulder surgery and underwent USG-guided interscalene block and concomitant suprascapular block were included in the study. We tried to determine whether there is a difference between different dose regimens in order to determine the effective analgesic dose and minimize the side effects of dose-dependent interscalene block applications.

Eligibility criteria: Inclusion Criteria:

arthroscopic shoulder surgery full data form

Exclusion Criteria:

chronic obstructive lung disease chronic opoid consumption missing data from the postoperative pain form

Primary outcomes:
measure: rescue analgesia
timeFrame: between 01.01.2019 and 01.03.2020
measure: difference between the analgesic methods
timeFrame: between 01.01.2019 and 01.03.2020
Secondary outcomes:
Other outcomes:
Locations:
city: Eskişehir
country: Turkey
facility: Ferda YAMAN
state: Odunpazarı
Study officials:
affiliation: University of Eskişehir Osmangazi
name: Ferda YAMAN, Assoc prof
role: STUDY_DIRECTOR
References:
Clinical trial NCT00952471: Reduction in Clinical Variance Using Targeted Design Changes in Computerized Provider Order Entry Order (CPOE) Sets
Official title: Reduction in Clinical Variance Using Targeted Design Changes in Computerized Provider Order Entry Order (CPOE) Sets
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Asthma Exacerbation
Keywords: Asthma
Children
CPOE
Decision Support
Framing
Heuristic
Order Sets
Lead sponsor: Children's National Research Institute
Sponsor class: OTHER
Collaborators: name: Siemens Medical
First posted: 2009-08-06
Enrollment: 458
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: Selective redesign of order sets using different ways to frame the order and physician decision-making in a computerized provider order entry system could increase adherence to evidence-based care and reduce population-specific variance.

Detailed description: Variance in ordering of care can be characterized as the lack of uniform use of specific treatments by clinicians for a given medical condition. Unwarranted variance in healthcare has been associated with prolonged length of stay, diminished health and increased cost. Practice variation in the management of asthma can be significant and few investigators have evaluated strategies to reduce this variation. We hypothesized that selective redesign of order sets using different ways to frame the order and physician decision-making in a computerized provider order entry system could increase adherence to evidence-based care and reduce population-specific variance.

Eligibility criteria: Inclusion Criteria:

* All patients admitted using an acute asthma exacerbation order set.

Exclusion Criteria:

* Patients who did not have either an admission or discharge diagnosis of asthma exacerbation.
* In addition, patients admitted to the intensive care unit directly or transferred to the intensive care unit within 24-hours were excluded from analysis.
* Finally, patients were excluded from analysis if asthma was not the presenting problem.

Primary outcomes:
measure: Reduced variation from in evidence-based care through integrating evidence into the clinician workflow in the EMR system.
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Cincinnati
country: United States
facility: Cincinnati Children's Hospital Medical Center
state: Ohio
Study officials:
References:
Clinical trial NCT04830371: Non-inferiority and Safety Study of EuTCV Compared to Typbar-TCV in Healthy 6 Months-45 Years Aged Participants
Official title: A Phase II/III, Multicenter, Observer-Blinded, Randomized, Non-inferiority and Safety Study of Typhoid Conjugate Vaccine (EuTCV) Compared to Typbar-TCV in Healthy 6 Months-45 Years Aged Participants
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
PHASE3
Conditions: Typhoid Fever
Lead sponsor: EuBiologics Co.,Ltd
Sponsor class: INDUSTRY
First posted: 2021-04-05
Enrollment: 444
Sex: ALL
Minimum age (years): 6
Maximum age (years): 45
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: This is an observer-blinded, comparative, single dose, clinical phase II/III study to assess the immunogenicity and safety of EuTCV compared to Typhoid conjugate vaccine in healthy Filipino participants aged 6 months to 45 years.


Eligibility criteria: Inclusion Criteria:

1. Healthy participants ≥6 months and ≤45 years of age at enrolment
2. Participants/Parents/Legally Authorized Representative(LAR) willing to give written informed consent/assent to participate in the trial
3. Participants/Parents/LAR willing to follow the study procedures of the study and available for the entire duration of the study
4. Participants who are healthy as determined by medical history, with no clinically significant abnormalities in clinical examination and laboratory tests
5. Female participants must have a negative serum (at Screening) and negative urinary (at Day 1) pregnancy test and agree to use 2 methods of contraception from dosing until 90 days after vaccination.

Exclusion Criteria:

1. Participants/Parents/LAR unwilling to give his/her consent/assent to participate in the trial
2. Participants concomitantly enrolled or scheduled to be enrolled in another trial
3. Children and infants with a congenital abnormality
4. Known history of immune function disorders including immunodeficiency disease, or chronic use of systemic steroids, cytotoxic or other immunosuppressive drugs
5. Pregnant, lactating women or women of childbearing age not using a reliable method of contraception
6. History of uncontrolled coagulopathy or blood disorders
7. Any abnormality or chronic disease which in the opinion of the investigator might be detrimental for the safety of the participant and interfere with the assessment of the trial objectives
8. History of alcohol or substance abuse

Primary outcomes:
measure: Seroconversion rate
timeFrame: 4 weeks after vaccination of EuTCV (pooled of 3 batches)/Typbar-TCV compared to baseline
measure: Proportion of Solicited local and systemic AEs
timeFrame: 7 days after vaccination
measure: Proportion of unsolicited AEs
timeFrame: within 28 days after vaccination
Secondary outcomes:
Other outcomes:
Locations:
city: Cavite
country: Philippines
facility: De La Salle Medical and Health Sciences Institute
city: Quezon City
country: Philippines
facility: University of the East Ramon Magsaysay Memorial Medical Center
Study officials:
References:
Clinical trial NCT03656471: Comparison of Subjective Experiences Between Patients Receiving Clear Aligners or Fixed Appliances
Official title: Comparison of Subjective Experiences Between Patients Receiving Clear Aligners or Fixed Appliances During the Initial Stage of Orthodontic Treatment
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pain
Anxiety
Quality of Life
Lead sponsor: West China Hospital
Sponsor class: OTHER
First posted: 2018-09-04
Enrollment: 160
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients receiving either clear aligner or conventional fixed appliance treatments from December 2013 to December 2015 in West China Hospital of Stomatology were enrolled in this study.

Brief summary: This study aimed to compare experiences between adult patients receiving clear aligners and fixed appliances during the initial stage of orthodontic treatments.

Detailed description: Patients receiving either clear aligner treatments were enrolled in this study. During the same time period, patients receiving fixed orthodontic treatments well-matched with clear-aligner patients by similar ages (difference \< 3 years), same gender and similar levels of severity of malocclusion \[similar Index of Complexity Outcome and Need (ICON) level\] were enrolled.The two groups were well-matched with ages, gender and levels of malocclusion severity. Pain perception, anxiety and quality of life were assessed through visual analogue scale (VAS), state-trait anxiety inventory (STAI) and oral health impact profile-14 (OHIP-14), respectively.

Eligibility criteria: Inclusion Criteria:

* Must be 18 years of age or older;
* Must be in good general health;
* Upper and lower arches were both involved in two groups;
* The fixed appliances group must be treated with wires and brackets only with the initial arch wire of 0.012 NiTi ;
* Must be willing to sign and give written informed consent in accordance with institutional and federal guidelines.

Exclusion Criteria:

* Once been undergoing with orthodontic treatment;
* Experienced tooth ache recently;
* Been diagnosed with contagious and/or systematical diseases;
* Have taken any kind of painkillers three days before the initial treatment;
* When Trait Anxiety Inventory (T-AI) shows a score believed to define a psychological state of over anxiety (male over 53 points and female over 55 points).

Primary outcomes:
measure: The chronological changes in pain perception
timeFrame: Baseline, Day 1, Day 2，Day 3，Day 4，Day 5，Day 6，Day 7,and Day 14
Secondary outcomes:
measure: The chronological changes of anxiety level
timeFrame: Baseline, Day 1,Day 3,Day 5,Day 7 and Day 14
measure: The chronological changes in quality of life
timeFrame: Baseline,Day 1 ,Day 7 and Day 14
Other outcomes:
Locations:
Study officials:
affiliation: West China Hospital of Stomatology, Sichuan University, Chengdu, China
name: Hu Long, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01520571: Do We Need Computer Assistance To Improve the Survival of Primary Total Knee Arthroplasty. A Minimum Ten Years Follow-up
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Osteoarthritis
Keywords: Computer Assistance
Total Knee Arthroplasty
conventional
Lead sponsor: Ewha Womans University
Sponsor class: OTHER
First posted: 2012-01-30
Enrollment: 520
Sex: ALL
Minimum age (years): 49
Maximum age (years): 88
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The investigators asked: (1) Do computer-assisted total knee arthroplasty (TKAs) provide better alignment and clinical function? (2) Do computer-assisted TKAs provide better survivorship of implants and less complication? and (3) Do correction of the mechanical axis of the lower limb to within 3° of neutral is a prognostic marker for late revision surgery due to aseptic loosening?

Detailed description: Computer-assisted total knee arthroplasty (TKA) is reported to improve the overall accuracy of positioning of the femoral and tibia components. However, an acceptable target for alignment remains a matter for debate. A mechanical axis within 3° of neutral axis has been used as the primary outcome measure in many clinical trials comparing computer-assisted- and conventional TKA. However, the evidence supporting this arbitrary value is unreliable because previous reports are limited by their small sample size, inadequate radiographs, short follow-up and lack of clarity when defining a margin of accuracy.

Eligibility criteria: Inclusion Criteria:

* End stage osteoarthritis of the knee joint who require total knee arthroplasty with bilateral lesions.

Exclusion Criteria:

* Inflammatory disease
* patient with other Lower extremity disease which may affect functional outcome
* Neurologic disease effecting patients lower extremity
* Revision surgery
* Patient not medically cleared for bilateral surgery

Primary outcomes:
measure: Improvement in Knee Society Knee Score
timeFrame: 10.5 years
Secondary outcomes:
measure: Improvement in the range of motion
timeFrame: 10.5 years
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Ewha Womans University Mokdong Hosptial
Study officials:
affiliation: Ewha Womans University School of Medicine
name: Young-Hoo Kim, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT01894971: The Effect of Ligasure® to Destroy Cornual Portion of Fallopian Tube
Official title: The Effect of Thermal Damage of Ligasure® to Destroy Cornual Portion of Fallopian Tube Tissue
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Recruiting
Completed
Lead sponsor: Samsung Medical Center
Sponsor class: OTHER
First posted: 2013-07-10
Enrollment: 40
Sex: FEMALE
Minimum age (years): 35
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Single-center prospective randomized trial to evaluate the effect of thermal damage of Ligasure® to destroy cornual portion of fallopian tube tisse.

Right of Left side of fallpian tube is randomized and coagulated one more time than other side before cut off. The pathologist evaluate the amount of fallopian tube tissue left at both cornual portion of cut off specimen.

Detailed description: When investigators perform salpingectomy, both side of cornual portion of the uterus are coagulated by Ligasure®. The randomized, the same word selected side of the fallopian tube is coagulated one more time at the cornual portion than unselected other side of fallopian tube. Hypothesis is that the side selected and coagulated twice would have less fallopian tube tisse left at fianl pathology than the side only once coagulated by Ligasure®.

Eligibility criteria: Inclusion Criteria:

* female 35-50
* premenopausal
* plan to perform hysterectomy

Exclusion Criteria:

* disease in fallopian tube before surgery
* has history of pelvic inflammatory disease

Primary outcomes:
measure: Remnant fallopian tube tissue after coagulation wiht Ligasure®
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
Study officials:
affiliation: Samsung Medical Center
name: Tae Joong Kim, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Unable to connect to PubMed to validate , last attempt on June 25, 2013 at 11:11 AM EDT
Clinical trial NCT00541671: Prevention of Narcotic-Induced Nausea
Official title: Prevention of Narcotic-induced Nausea With Promethazine, a Randomized, Double-blind Placebo-controlled Trial
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Nausea
Keywords: Narcotics
Nausea
Lead sponsor: Christiana Care Health Services
Sponsor class: OTHER
First posted: 2007-10-10
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: We are doing this study to find out if extra medicine is needed to avoid the chance of nausea sometimes linked to narcotic pain medicine (for example, morphine, dilaudid, fentanyl). Some doctors always give medicine to prevent the possible side effect of nausea, while others do not. We are looking to see if this extra medicine is helpful in preventing nausea. The goal is to screen all patients with pain and enroll enough subjects to reach our goal of 164 evaluable study participants.

Detailed description: Patients will be randomized to one of two study groups. They will then be asked to rate their pain and nausea on a line graph. If the patient is a female of child bearing age, a urine pregnancy test will be done per standard of care. After this, an IV catheter will be placed in a vein in the patients arm. Pain medicine will be given through this IV per the doctor's order. With this medicine, patients will be given 10 milliliters (2 teaspoons) of either Sodium Chloride (salt water) or Phenergan mixed with Sodium Chloride (salt water). Phenergan is a medication typically used to help with nausea and is a common ingredient in prescription cough medicine.

After this is finished, patients will be asked to rate their pain and nausea in 30 minutes, and again 1, 2, and 4 hours later. If the doctor decides the patient is able to be discharged from the emergency room before the 4 hours are up, they will be asked to rate your pain and nausea again before going home, and the study will be stopped at that time.

Eligibility criteria: Inclusion Criteria:

1. Patient in Christian Care Emergency Department
2. Require intravenous narcotics for painful condition
3. ≥18 years of age
4. Able to visually rate amount of pain and nausea

Exclusion Criteria:

1. Hypersensitivity to promethazine or opioids
2. Patient requesting anti-emetic at enrollment
3. Narcotic administration in last 6 hours
4. Pregnancy or currently breast-feeding
5. Known seizure disorder
6. Medical Instability

Primary outcomes:
measure: Number of Patients Who Became Nauseated After IV Opiate Administration.
timeFrame: 4 hours post opiate administration
Secondary outcomes:
Other outcomes:
Locations:
city: Newark
country: United States
facility: Christiana Care Health Services
state: Delaware
Study officials:
affiliation: Christiana Care Health Services
name: Michael Perraut, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01956071: Workers' Acceptability of a Prototype Integrated and Interactive Pedal Desk
Official title: Workers' Acceptability of a Prototype Integrated and Interactive Pedal Desk
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Acceptability of Semi-recumbent Pedal Desk
Lead sponsor: Pennington Biomedical Research Center
Sponsor class: OTHER
First posted: 2013-10-08
Enrollment: 44
Sex: ALL
Minimum age (years): 21
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DEVICE_FEASIBILITY

Brief summary: The purpose of this study is to assess full-time workers'impressions and acceptability of a prototype pedal desk. The pedal-desk is a semi-recumbent (upright) portable pedal mechanism that allows workers to complete tasks in a traditional seated position.

Detailed description: Researchers in recent years have begun to consider how modern occupational practices and environments could be enriched to facilitate increased energy expenditure by replacing sedentary behaviors with opportunities for non-exercise physical activity without competing with time committed to work tasks. The investigators have developed a pedal desk: a semi-recumbent (upright) portable pedal mechanism with a maneuverable and adaptable desktop. While utilizing the pedal desk, workers are able to complete their tasks in a more traditional seated position. Determining workers' acceptability is a key initial step in translating this "sedentary behavior countermeasure" to real workplace settings.

In addition to having their height, weight, body fat percentage, and bioelectrical impedance measured, eligible participants will be asked to complete three tasks while simultaneously pedaling at a sustainable and self-selected pace. The three tasks are: 1) compose and send an email; 2) search a topic on the internet, and 3) complete an on-line questionnaire. The questionnaire that participants will complete was developed specifically for this study, utilizes Likert scales, and is based on the Theory of Planned Behavior. Constructs tested focus on perceptions of using the pedal desk at work and include: behavioral beliefs, normative beliefs, control beliefs, intention, self-efficacy, and an open-ended question soliciting general impressions concerning using the pedal desk at work.

Eligibility criteria: Inclusion Criteria:

* full-time employee at Pennington Biomedical Research Center
* between ages 21 and 65
* self-report primarily sitting while at work
* comfortable sending emails and searching topics on the internet

Exclusion Criteria:

* weigh more than 250 pounds
* have physical limitations that prevent performance of pedaling motions
* pregnancy
* pacemaker or metal joint replacement

Primary outcomes:
measure: Pedal Desk Trial Questionnaire
timeFrame: Visit 1
Secondary outcomes:
Other outcomes:
Locations:
city: Baton Rouge
country: United States
facility: Pennington Biomedical Research Center
state: Louisiana
Study officials:
References:
Clinical trial NCT01429571: The Role of Antibiotics After Surgical Treatment of Simple Hand Infections: A Prospective Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hand Infections
Lead sponsor: BG Trauma Center Tuebingen
Sponsor class: OTHER
First posted: 2011-09-07
Enrollment: 90
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult patients with simple hand infections (no infection of the bone, tendon or joint)

Brief summary: Three patient groups with simple hand infections are tested regarding the necessity of antibiotics after surgical treatment.


Eligibility criteria: Inclusion Criteria:

* Adult patients with simple hand infections

Exclusion Criteria:

* Infection of the bone, tendon or joint
* Major diseases like diabetes or immunodeficiency
* Systemic manifestations like fever or lymphangitis
* Bite infections

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Tuebingen
country: Germany
facility: BG Trauma Center
Study officials:
References: