Clinical trial NCT05976178: Study of the Characteristics of Chronic Pain in Patients With Addiction
Official title: Descriptive, Prospective Study of the Characteristics of Chronic Pain in Patients With Addiction to at Least One Substance
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Chronic Pain
Addiction
Lead sponsor: Groupe Hospitalier de Bretagne Sud
Sponsor class: OTHER
First posted: 2023-08-04
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients hospitalized in the addictology department of LORIENT Hospital, in full hospitalization or in a day hospital

Brief summary: It is described in the literature a higher prevalence of pain in patients with an addiction but there are few studies describing the pain profile of patients with use disorder.

Pain has a very negative impact on the quality of life of opioid substituted patients. Improving knowledge on this point would make it possible to better guide specific care.

The investigator proposes to conduct a single-center descriptive observational study using questionnaires, without changing the management of patients with chronic pain.

The primary objective of the study is to determine the prevalence of chronic pain in patients with substance addiction hospitalized for addiction treatment.

Detailed description: It is described in the literature a higher prevalence of pain in patients with an addiction but there are few studies describing the pain profile of patients with use disorder.

Pain has a very negative impact on the quality of life of opioid substituted patients. Improving knowledge on this point would make it possible to better guide specific care.

The investigator proposes to conduct a single-center descriptive observational study using questionnaires, without changing the management of patients with chronic pain. All patients admitted to hospitalization in the addiction department of the LORIENT Hospital will be offered participation in the study.

The primary objective of the study is to determine the prevalence of chronic pain in patients with substance addiction hospitalized for addiction treatment.

The study will also evaluate the impact on daily activities of the presence of two chronic pathologies: chronic pain and addiction, describe the frequency of the two main psychiatric comorbidities of chronic pain: anxiety and depression, describe the different components of chronic pain in patients with substance addiction, and get information on analgesic medications.

Eligibility criteria: Inclusion Criteria:

* \> 18 years old
* Presence of addiction to at least one substance, based on DSM-5 criteria
* Hospitalized in the addiction service of LORIENT Hospital
* Knowing how to read and write French
* Not objecting to their participation in the study after informed information

Exclusion Criteria:

* Already included during a precedent hospitalization
* Adults subject to legal protection or deprived of their liberty.

Primary outcomes:
measure: Prevalence of chronic pain in patients with substance addiction hospitalized for addiction treatment.
timeFrame: During the hospitalization, maximum 1 month
Secondary outcomes:
measure: Pain intensity in the last 24 hours
timeFrame: During the hospitalization, maximum 1 month
measure: Interference of pain on the quality of life
timeFrame: During the hospitalization, maximum 1 month
measure: Localisation of pain
timeFrame: During the hospitalization, maximum 1 month
measure: Describe the frequency of the two main psychiatric comorbidities of chronic pain: anxiety
timeFrame: During the hospitalization, maximum 1 month
measure: Describe the frequency of the two main psychiatric comorbidities of chronic pain: depression
timeFrame: During the hospitalization, maximum 1 month
measure: Describe the prevalence of fibromyalgia among patients with substance addiction
timeFrame: During the hospitalization, maximum 1 month
measure: Information on analgesics medication
timeFrame: During the hospitalization, maximum 1 month
measure: Describe the prevalence of neuropathic pain among patients with substance addiction
timeFrame: During the hospitalization, maximum 1 month
Other outcomes:
Locations:
city: Lorient
country: France
facility: Groupe Hospitalier Bretagne Sud
Study officials:
affiliation: GH Bretagne Sud
name: Alexandre Cauchie, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Rosenblum A, Joseph H, Fong C, Kipnis S, Cleland C, Portenoy RK. Prevalence and characteristics of chronic pain among chemically dependent patients in methadone maintenance and residential treatment facilities. JAMA. 2003 May 14;289(18):2370-8. doi: 10.1001/jama.289.18.2370.
citation: Lusted A, Roerecke M, Goldner E, Rehm J, Fischer B. Prevalence of pain among nonmedical prescription opioid users in substance use treatment populations: systematic review and meta-analyses. Pain Physician. 2013 Nov-Dec;16(6):E671-84.
citation: Breivik H, Collett B, Ventafridda V, Cohen R, Gallacher D. Survey of chronic pain in Europe: prevalence, impact on daily life, and treatment. Eur J Pain. 2006 May;10(4):287-333. doi: 10.1016/j.ejpain.2005.06.009. Epub 2005 Aug 10.
citation: Voon P, Greer AM, Amlani A, Newman C, Burmeister C, Buxton JA. Pain as a risk factor for substance use: a qualitative study of people who use drugs in British Columbia, Canada. Harm Reduct J. 2018 Jul 5;15(1):35. doi: 10.1186/s12954-018-0241-y.
citation: Larson MJ, Paasche-Orlow M, Cheng DM, Lloyd-Travaglini C, Saitz R, Samet JH. Persistent pain is associated with substance use after detoxification: a prospective cohort analysis. Addiction. 2007 May;102(5):752-60. doi: 10.1111/j.1360-0443.2007.01759.x.