louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06924671: GLA:D Back Canada - a Program for Chronic and Persistent Low Back Pain
Official title: GLA:D Back Canada - a Program for Persistent Low Back Pain.
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Low Back Pain
Keywords: Low Back Pain
Lead sponsor: University of Alberta
Sponsor class: OTHER
First posted: 2025-04-11
Enrollment: 2200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: English speaking adults greater than 18 years of age.

Brief summary: GLA:D Back is a program developed in Denmark to help people with persistent low back pain. This study will assist in contextualizing Danish content into an English version of the program.

Detailed description: GLA:D Back is a program developed in Denmark to help people with persistent low back pain. Unfortunately, all materials developed for the program are in Danish. In this pilot, the investigators will translate the Danish materials into English, then use them to conduct an English training session for community clinicians in Edmonton, Alberta, Canada. Interested clinicians will then implement the program in their communities and provide feedback to contextualize the program for use in English. Specifically, surveys, interviews and focus groups will be used to help fine-tune the printed content of the course (e.g. manuals), it's training materials (e.g. lectures) and processes related to REDCap data collection (e.g. surveys).

Eligibility criteria: Inclusion Criteria:

* Patients must have persistent low back pain of at least 1 month's duration.

Exclusion Criteria:

* Participating currently in a supervised exercise or rehabilitation program or enrolled in another interventional clinical trial.
* Patients with nerve root involvement, suspected serious pathology, unstable trauma to the spine, aspects of pregnancy or other conditions that would prevent participation or disallow trial completion within the prescribed time period.
* Persons with conditions that require a specialist consult are suspected of needing a specialist consult, or have conditions that would be aggravated or worsened if treated by the interventions in this study.

Primary outcomes:
measure: Implementation
timeFrame: 6 months
Secondary outcomes:
measure: Patients enrolled
timeFrame: 6 months
Other outcomes:
Locations:
city: Edmonton
country: Canada
facility: University of Alberta
state: Alberta
Study officials:
References:
Clinical trial NCT06985771: Predictive Ability of Different Frailty Indices for Postoperative Infections in Elderly Patients
Official title: Evaluating the Predictive Ability of Different Frailty Indices for Postoperative Infections in Elderly Patients: Data Analysis From a Prospective Multicenter Observational Cohort
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Postoperative Infections
Frailty
Keywords: Frailty
Postoperative Infection
elderly patients
Lead sponsor: Chinese PLA General Hospital
Sponsor class: OTHER
Collaborators: name: The First Medical Center of Chinese PLA General Hospital
First posted: 2025-05-22
Enrollment: 10536
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The patients aged 65 and older who were involved in the prospective cohort of postoperative adverse events in elderly patients from April 2020 to April 2022.

Brief summary: In this study, we extracted data from the patients medical record within the cohort to compare five existing frailty indices: the 5-Item Modified Frailty Index (mFI-5), the Electronic Frailty Index (eFI), the Frailty Index based on Comprehensive Geriatric Assessment (FI-CGA), the Frailty Risk Assessment Instrument for the Elderly based on Laboratory and Clinical Indicators (FRAIL), and the Hospital Frailty Risk Score (HFRS). The study aims to evaluate the predictive values of each electronic frailty index for the incidence of postoperative infection-related adverse events. This includes the primary outcome of infection events occurring within 30 days and the secondary outcome of the correlations among the five frailty indices.


Eligibility criteria: Inclusion Criteria:

1. Aged 65 and above
2. Patients who underwent Non-Cardiac surgeries and anesthesia

Exclusion Criteria:

1. Patients who underwent surgery within 30 days before the current procedure;
2. Patients with missing baseline demographic data;
3. Patients with incomplete medical records that resulted in the inability to fully assess all five frailty indices;
4. Patients with missing data related to primary and secondary outcomes after surgery.

Primary outcomes:
measure: Postoperative infection events within 30 days postoperatively
timeFrame: Within 30 days postoperatively
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: The First Medical Center of Chinese PLA General Hospital
state: Beijing
Study officials:
affiliation: The First Medical Center of Chinese PLA General Hospital
name: Jingsheng Lou, Doctor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03024671: Epicutaneous Testing of Cosmetics for Skin Compatibility
Official title: Epicutaneous Testing of Cosmetic Products to Determine Skin Compatibility
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Dermatitis
Lead sponsor: Insel Gruppe AG, University Hospital Bern
Sponsor class: OTHER
Collaborators: name: Mibelle AG
First posted: 2017-01-19
Enrollment: 180
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: The dermatological testing of cosmetic products which are new on the market, or existing products with novel formulations is common and a useful procedure, yet necessary to alleviate common irritants and contact allergic reactions. Cosmetic products contain a range of substances that may be considered as potential irritants or contact allergens. In order to estimate that risk, cosmetics are tested by applying patch tests.

Detailed description: The dermatological testing of cosmetic products which are new on the market, or existing products with novel formulations is common and a useful procedure, yet necessary to alleviate common irritants and contact allergic reactions. Cosmetic products contain a range of substances that may be considered as potential irritants or contact allergens. In order to estimate that risk, cosmetics are tested by applying patch tests, as with allergic reactions.

Eligibility criteria: Inclusion Criteria:

* Men and women older than 18 years old
* Persons undergoing a diagnostic patch test for reason of a skin disease
* Signed written informed consent

Exclusion Criteria:

* Acute skin inflammation and eczema on the back
* Systemic corticosteroid and immunosuppressive therapy as well as UV exposure of the back within the last 4 weeks
* Topical corticosteroids used on the back within the last two weeks

Primary outcomes:
measure: Number of patients with positive patch test reactions to cosmetics
timeFrame: 4 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Bern
country: Switzerland
facility: Inselspital Bern
Study officials:
affiliation: Dept. of Dermatology, Inselspital
name: Dagmar Simon, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01475071: Intra-individual Comparison of Efficacy and Safety of Metvix® Natural Daylight Photodynamic Therapy Versus Conventional Metvix® Photodynamic Therapy in Subject With Mild Actinic Keratoses
Official title: Intra-individual Comparison of Efficacy and Safety of Metvix® Natural Daylight Photodynamic Therapy Versus Conventional Metvix® Photodynamic Therapy in Subject With Mild Actinic Keratoses.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Actinic Keratoses
Lead sponsor: Galderma R&D
Sponsor class: INDUSTRY
First posted: 2011-11-21
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The main objective of this study is to compare efficacy and safety of Metvix® natural daylight photodynamic therapy with those of Metvix® conventional photodynamic therapy with Aktilite™ lamp in subjects with mild actinic keratoses (intra-individual comparison).


Eligibility criteria: Inclusion Criteria:

1. Male or female above 18 years;
2. Subject with clinical diagnosis of mild AK on the face or the scalp with or without clinical diagnosis of moderate AK on the target areas (TAs);

Exclusion Criteria:

1. Subject with clinical diagnosis of at least one severe AK on TAs
2. Subject with clinical diagnosis of other skin disease (including non-melanoma skin cancer) on the TAs;
3. Subject with pigmented AK on the TAs

Primary outcomes:
measure: Lesion Response
timeFrame: Week12
measure: Pain Score
timeFrame: Baseline (during procedure), assessed after procedure
Secondary outcomes:
Other outcomes:
Locations:
city: Phillip
country: Australia
facility: Galderma Investigational site
state: Australian Capital Territory
city: Kogarah
country: Australia
facility: Galderma Investigational Site
state: New South Wales
city: Sydney
country: Australia
facility: Galderma Investigational site
state: New South Wales
city: Westmead
country: Australia
facility: Galderma Investigational site
state: New South Wales
city: Woolloongabba
country: Australia
facility: Galderma Investigational site
state: Queensland
city: Carlton
country: Australia
facility: Galderma Investigational site
state: Victoria
Study officials:
affiliation: St George Dermatology and skin Cancer Center
name: Stephen Shumack
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04393571: The Utility of Mobile Based Patient Reported Outcome Measures in Patients With Acetabular Fractures: A Randomized Controlled Trial.
Official title: The Utility of Mobile Based Patient Reported Outcome Measures(PROMS) in Patients With Acetabular Fractures: A Randomized Controlled Trial.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Acetabular Fracture
PROMs
Mobile Phone Use
Lead sponsor: Assiut University
Sponsor class: OTHER
Collaborators: name: AO Trauma
First posted: 2020-05-19
Enrollment: 138
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Acetabular fractures are articular fractures involving the hip joint that needs anatomical reduction and a strict long follow up after fixation.

Detailed description: The percentage of patients with lost follow up is significantly high. Previously all other studies mainly focused on the radiographic outcome after acetabular fractures and rarely on patient reported functional outcomes and quality of life. The use of patient-reported outcome measures (PROMs) is increasing and may lead to modifications of treatment. Recent technologic advances, namely smartphones, capable of measuring outcomes after acetabular fractures are now very important in quantifying value-based care. This was previously accomplished through office assessments and surveys with variable follow-up but this strategy lacks continuous and complete data. Studies show that these remote modes of follow-up are safe and that patients are as equally satisfied with them as they are with in-person follow- up care

Eligibility criteria: Inclusion Criteria:

* all patients older than 18 years old who will have surgery for an acetabular fracture at assiut university hospitals from 1/10/2020 to 30/9/2022.

Exclusion Criteria:

* patients younger than 18 years.

Primary outcomes:
measure: the percentage of missed follow up data in both groups at 12 months postoperatively
timeFrame: at least one year follow up
Secondary outcomes:
measure: the ability of the mobile application to rapidly detect the occurrence of serious postoperative complication.
timeFrame: at least one year follow up
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03759171: Music-instruction Intervention for Treatment of Post-traumatic Stress Disorder
Official title: Music-instruction Intervention for Treatment of Post-traumatic Stress Disorder: A Randomized Pilot Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Stress Disorders, Post-Traumatic
Depression
Lead sponsor: Medical College of Wisconsin
Sponsor class: OTHER
Collaborators: name: VA Office of Research and Development
name: Milwaukee VA Medical Center
First posted: 2018-11-29
Enrollment: 40
Sex: ALL
Minimum age (years): 21
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Delayed entry, randomized trial
Primary purpose: TREATMENT

Brief summary: The purpose of this study was to examine the feasibility and potential effectiveness of an active, music-instruction intervention in improving psychological health and social functioning among Veterans suffering from moderate to severe Post-traumatic Stress Disorder (PTSD).

Detailed description: The study was designed as a prospective, delayed-entry randomized pilot trial. Regression-adjusted difference in means were used to examine the intervention's effectiveness with respect to PTSD symptomatology (primary outcome) as well as depression, perceptions of cognitive failures, social functioning and isolation, and health-related quality of life (secondary outcomes).

Eligibility criteria: Inclusion Criteria:

* Veterans who (i) had at least one visit for mental health treatment in the prior six months with a primary diagnosis of PTSD (ICD9CM 309.81-83) and (ii) exhibited moderate to severe PTSD symptoms at the time of enrollment (Posttraumatic Stress Disorder Checklist \>=50)

Exclusion Criteria:

* Veterans who were currently participating in an intense psychotherapy program (residential or outpatient)
* Veterans who were already receiving guitar lessons from a Guitars for Vets volunteer

Primary outcomes:
measure: Post-Traumatic Stress Disorder (PTSD) Symptoms
timeFrame: 6 weeks
Secondary outcomes:
measure: Depression
timeFrame: 6 weeks
measure: Perceptions of Cognitive Failures
timeFrame: 6 weeks
measure: Social Functioning
timeFrame: 6 weeks
measure: Health-Related Quality of Life
timeFrame: 6 weeks
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01845571: Retinal Detachment - Demographic and Clinical Survey
Official title: Long-term Anatomic and Funcional Succes After Surgery in Eyes With Retinal Detachment
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Rhegmatogenous Retinal Detachment
Lead sponsor: Medical University of Vienna
Sponsor class: OTHER
First posted: 2013-05-03
Enrollment: 400
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: People will be selected from the surgery database of Ass.Prof.PD.Dr. Stefan Sacu and Prof. Dr. Michael Georgopoulos from the Medical University of Vienna.

Brief summary: Background:

Rhegmatogenous retinal detachment is an ophthalmic emergency that, without surgical repair, often leads to blindness. The incidence is about 1/10000/year. The leading causes are myopia and aging which cause retinal tears often resulting in retinal detachment. Patients commonly experience photopsia, floaters, and peripheral visual field loss.

Two different general surgical treatment options exist for retinal detachment; scleral buckling or vitrectomy. However, the precise indications for each approach have not been well established. Correct classification of the retinal detachment is important. The first step is to decide whether an intra- or extra-ocular surgical approach is more appropriate. Simple rhegmatogenous retinal detachments are usually treated extraocularly with scleral buckling surgery, whereas more complicated cases require intraocular primary pars plana vitrectomy and one or more of gas, silicone oil, laser therapy, or cryotherapy.

Study objectives:

The purpose of this study is to evaluate different surgical techniques for the treatment of retinal detachment. Data relating to retinal status before treatment, surgical treatment, post-operative anatomy and visual acuity, post-operative OCT, and intra- and post-operative complications will be collected.

Vitreous cytokines will also be analyzed to monitor intravitreal inflammation as a result of retinal detachment.


Eligibility criteria: Inclusion Criteria:

Patients who received surgery due to retinal detachment between January 2008 and Decemebr 2012.

Surgery was performed by either Ass.Prof.PD.Dr. Stefan Sacu or Prof.Dr. Michael Georgopoulos

Exclusion Criteria:

If patients had prior vitrectomy or scleral buckel. If patients had no adequate follow-up.

Primary outcomes:
measure: Vision
timeFrame: 2 years
measure: Aqueous cytokine Levels
timeFrame: baseline
Secondary outcomes:
measure: OCT
timeFrame: baseline
measure: Surgical Data
timeFrame: 2 years
Other outcomes:
Locations:
city: Vienna
country: Austria
facility: Insitute of Ophthalmology and Optometry, Medical University of Vienna
Study officials:
affiliation: Medical University of Vienna
name: Stefan Sacu, Prof
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02565771: Evaluation of the Improvement of Autonomic Nervous System by a Physical Rehabilitation Program Adapted to Adulthood After Chemotherapy or Radiotherapy in Childhood
Official title: Evaluation of the Improvement of Autonomic Nervous System by a Physical Rehabilitation Program Adapted to Adulthood After Chemotherapy or Radiotherapy in Childhood
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cancer
Sequels
Complications
Keywords: Childhood cancer
Cancer
Sequels
Surgery
Complications
Chemotherapy
Radiotherapy
Lead sponsor: Centre Hospitalier Universitaire de Saint Etienne
Sponsor class: OTHER
First posted: 2015-10-01
Enrollment: 6
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adults treated for childhood cancer in Rhône-Alpes region in France between 1987 and 1992 with deregulation ANS or autonomic imbalance.

Brief summary: Survival rate of childhood cancers is now reaching 80%. However, early or late complications related to surgery, chemotherapy and radiotherapy remain high and greatly increase the risk of late mortality.

Health of individuals is closely correlated to the stability of the autonomic nervous system (ANS), a key system for maintaining homeostasis in any living species. Efficient computer tools allowed the opportunity to assess the intrinsic autonomic regulation of the ANS either directly or at a later time by an analysis of the heart rate variability (HRV). These tools have become very powerful predictors of cardiovascular morbidity and neurological aging. Physical endurance training improves both maximal aerobic capacity and ANS activity.

Detailed description: The main objective of this study is to evaluate improvement of ANS parameters after 6 months of adapted physical activity in adults treated for childhood cancer in Rhône-alpes region in France who have deregulation ANS or autonomic imbalance.

Eligibility criteria: Inclusion Criteria:

* Included in the SALTO_SNA study (NCT01574196)
* Alteration of the autonomic nervous system activity or deregulation of the sympatho-vagal balance

Exclusion Criteria:

* Written consent form
* Left ventricular dysfunction

Primary outcomes:
measure: Autonomic nervous system activity
timeFrame: At 6 months
Secondary outcomes:
measure: Daily activity questionnaire
timeFrame: At 6 months
measure: Quality of Life Questionnaire
timeFrame: At 6 months
Other outcomes:
Locations:
city: Saint-etienne
country: France
facility: CHU de SAINT-ETIENNE
Study officials:
affiliation: CHU de SAINT-ETIENNE
name: Claire BERGER, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01127971: Patient Registry: Partial Breast Irradiation
Official title: Patient Registry: A Study of the Use of Accelerated Partial Breast Irradiation to Evaluate Local Tumor Control, Cosmetic Outcome and Toxicities
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Breast Cancer
Keywords: patients
receiving
irradiation
device
External Beam
Lead sponsor: Wake Forest University Health Sciences
Sponsor class: OTHER
First posted: 2010-05-21
Enrollment: 145
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Aurora Health Care system patients receiving accelerated partial breast irradiation

Brief summary: This is an Aurora Health Care system registry of patients receiving accelerated partial breast irradiation and external beam.


Eligibility criteria: Inclusion Criteria:

* Aurora patients who decide to undergo PBI treatment in the next 5-years or who have had PBI Treatment in the last ten-years. All such patients are female.

Exclusion Criteria:

* Patients not seen in an Aurora facility

Primary outcomes:
measure: The collection and analysis of sufficient data to determine 5 and 10-year local recurrence rates is collection and analysis of sufficient data to determine 5 and 10-year local recurrence rates
timeFrame: 5 and 10-year local recurrence rates
Secondary outcomes:
measure: collection and analysis of data to evaluate and compare cosmetic outcome
timeFrame: 5 and 10-year
Other outcomes:
Locations:
city: Green Bay
country: United States
facility: Aurora BayCare Medical Center
state: Wisconsin
Study officials:
affiliation: Aurora BayCare Medical Center
name: David Rohde, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00857571: A Four-Way Cross-Over Study To Compare The Plasma Concentrations Of PF-02413873 After Oral Administration Of Several Doses As Suspension And As Tablets.
Official title: An Open-Label Randomized Incomplete Block Four-Way Crossover Study To Evaluate The Dose Response Of PF-02413873 Tablets And PF-02413873 Suspension.
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE1
Conditions: Healthy
Keywords: Dose Response Bioavailability Study
Lead sponsor: Pfizer
Sponsor class: INDUSTRY
First posted: 2009-03-06
Enrollment: 12
Sex: ALL
Minimum age (years): 21
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: The study compares the plasma concentrations of PF-02413873 after administration of several doses as suspension and as tablets


Eligibility criteria: Inclusion Criteria:

* Healthy male and female volunteers.
* Female volunteers have to be of non-childbearing potential

Exclusion Criteria:

* Evidence or history of clinically significant hematological, renal, endocrine, pulmonary, gastrointestinal, cardiovascular, hepatic, psychiatric, neurologic, or allergic disease (including drug allergies, but excluding untreated, asymptomatic, seasonal allergies at time of dosing).
* Any condition possibly affecting drug absorption (eg, gastrectomy).
* A positive urine drug screen.

Primary outcomes:
measure: Pharmacokinetics: Cmax, AUCinf
timeFrame: June - July 2009
Secondary outcomes:
measure: Tmax, Tlag, AUClast, AUCt, t½, Frel.
timeFrame: June-July 2009
Other outcomes:
Locations:
city: Singapore
country: Singapore
facility: Pfizer Investigational Site
Study officials:
affiliation: Pfizer
name: Pfizer CT.gov Call Center
role: STUDY_DIRECTOR
References: