Clinical trial NCT02843997: Endophenotype Characterization of a Family Psychiatric Disorder
Official title: Endophenotype Characterization of a Family Psychiatric Disorder of the Bipolar Spectrum, With an Autosomal Dominant Expression
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Healthy Volunteer
Keywords: Bipolar disorder
Endophenotype
Family
Autosomal dominant expression
Sequencing
Heritability
Lead sponsor: University Hospital, Grenoble
Sponsor class: OTHER
First posted: 2016-07-26
Enrollment: 29
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP

Brief summary: Bipolar disorder is a chronic and frequent mood pathology, that impacts on emotional and socio-professional life of sick subjects, and also increase mortality by suicide. Suicide is considered as a bipolar disorder result.

The main goal of this study is the endophenotype characterization from a clinical and cognitive point of view, of a bipolar spectrum's disorder present in a family, and then highlight a mutation of one of the genes involved is this disorder.

Detailed description: Heritability of bipolar disorder is now well established, but seems to be multifactorial in most of the cases.

The use of an endophenotype characterized in a family presenting numerous bipolar sufferers enable to reflect the expression of simpler genetic variants than those involved in the disease, and might enable the identification of genes involved in the etiopathogenesis of this endophenotype.

Eligibility criteria: Inclusion Criteria:

* Members of a family adult (more than 18 years)
* Signed informed consents
* Registered to a French social security or possesor of the European Health Insurance Card

Exclusion Criteria:

Clinical part :

* Refusal to sign the participation study consent.
* Organic affection likely to affect cognitive abilities and brain structures or acute decompensation of a bipolar disorder.

Genetic part :

* Refusal to sign the genetic sample consent.

Primary outcomes:
measure: Neuropsychological evaluations tests
timeFrame: One day
measure: Eye tracking.
timeFrame: One hour
measure: Blood sampling
timeFrame: 3 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: La Tronche
country: France
facility: UniversityHospitalGrenoble
Study officials:
affiliation: Grenoble Hospital University
name: Jérôme Holtzmann, Doctor
role: PRINCIPAL_INVESTIGATOR
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