Clinical trial NCT05007054: Long-Term Outcomes in Patients With Three-Vessel Disease
Official title: Long-Term Outcomes of Different Treatment Strategies in Patients With Three-Vessel Coronary Disease
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Three Vessel Coronary Disease
Keywords: three-vessel coronary disease
percutaneous coronary intervention
coronary artery bypass grafting
medical therapy
clincial outcomes
Lead sponsor: The First Affiliated Hospital of Dalian Medical University
Sponsor class: OTHER
First posted: 2021-08-16
Enrollment: 4300
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with three-vessel coronary disease.

Brief summary: The long-term outcome of coronary artery bypass grafting (CABG), percutaneous coronary intervention (PCI), and medical therapy (MT) alone for triple-vessel disease (TVD) patients is controversial. The aim of this study is to evaluate the long-term outcome of TVD patients among these three treatment strategies, to find out the most appropriate treatment methods for these patients.

Detailed description: The present study was a retrospective observational study. Patients who underwent diagnostic coronary angiography from January 2013 to December 2018 were eligible for this study if they had three-vessel disease, which was defined as more than 50% stenosis in three major epicardial coronary arteries, left anterior descending, left circumﬂex, and right coronary artery. There were no pre-specified exclusion criteria. The choice of PCI, CABG, or MT was mainly followed the guidelines and based on clinical and angiographic features, physical condition (comorbidities, malignant tumor, frailty, etc.), complexity, and was discussed by physicians and surgeons, combined with the choice of patients. The PCI strategy and stent type were left to the physician's discretion.

The primary endpoint were major adverse cardiac and cerebrovascular events (MACCE), which were a composite of all-cause death, myocardial infarction (MI), repeat revascularization, or stroke. Clinical information of in-hospital outcome was obtained by reviewing medical records. Follow-up was completed by survey via telephone, letter, or hospital visit. All patients had at least one follow-up visit.

Eligibility criteria: Inclusion Criteria:

* Patients were diagnosed as having three-vessel disease (defined as angiographic stenosis of ≥ 50% in all three main epicardial coronary arteries, with or without left main artery involvement) and age \>18 years.

Exclusion Criteria:

* None

Primary outcomes:
measure: Major adverse cardiac and cerebrovascular events (MACCE)
timeFrame: The median follow-up time was 2.4 years.
Secondary outcomes:
measure: Cardiac death, MI, repeat revascularization, stroke, or hospitalization for angina pectoris or heart failure
timeFrame: The median follow-up time was 2.4 years.
Other outcomes:
Locations:
city: Dalian
country: China
facility: The First Affiliated Hospital of Dalian Medical University
state: Liaoning
Study officials:
affiliation: The First Affiliated Hospital of Dalian Medical University
name: Lei Guo, MD
role: PRINCIPAL_INVESTIGATOR
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