Clinical trial NCT05092061: Resistance Training in Adults With Obesity
Official title: Acute and Chronic Effects of Two Different Types of Resistance Training on Cardiometabolic Health in Adults With Obesity
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Overweight and Obesity
Keywords: Exercise therapy
Muscular strength
Resistance training
Fitness testing
Healthy lifestyle
Lead sponsor: Norwegian University of Science and Technology
Sponsor class: OTHER
First posted: 2021-10-25
Enrollment: 31
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: The study will consist of both a crossover study model (acute phase) and parallel model (chronic phase).
Primary purpose: PREVENTION

Brief summary: The purpose of this project is two-fold: (1) to assess if two different resistance training protocols elicit different responses in the acute phase and (2) to assess if the same two different protocols will elicit different long-term responses on muscular strength, body composition and cardiometabolic health. The project will include 30 adults with obesity (defined as BMI ≥ 30 or abdominal obesity according to the International Diabetes Federation). In the acute phase blood lactate, heart rate, enjoyment and perceived exertion will be assessed after the two resistance training protocols. In addition, the mean 24-h blood glucose concentration after exercise will be compared between the two protocols.

For the long-term effects blood markers of cardiometabolic health, blood pressure, body composition, objectively measured physical activity and physical fitness will be assessed before and after the intervention. Also, perceived health-related quality of life will be assessed before and after the intervention.


Eligibility criteria: Inclusion Criteria:

* Obesity (BMI ≥ 30) or
* Central obesity (defined according to the International Diabetes Federation).

Exclusion Criteria:

* Unstable angina
* recent cardiac infarction (last 4 weeks)
* uncompensated heart failure
* severe valvular illness
* pulmonary disease
* uncontrolled hypertension
* kidney failure
* orthopaedic/neurological limitations
* cardiomyopathy
* planned operations during the research period
* participation in a parallel study

Primary outcomes:
measure: Glycated haemoglobin (HbA1c)
timeFrame: 7 weeks
Secondary outcomes:
measure: Fasting glucose
timeFrame: 7 weeks
measure: Blood lipid concentration
timeFrame: 7 weeks
measure: C-reactive protein
timeFrame: 7 weeks
measure: Systolic blood pressure
timeFrame: 7 weeks
measure: Diastolic blood pressure
timeFrame: 7 weeks
measure: Body fat
timeFrame: 7 weeks
measure: Fat-free mass
timeFrame: 7 weeks
measure: Body mass
timeFrame: 7 weeks
measure: Visceral fat area
timeFrame: 7 weeks
measure: Waist circumference
timeFrame: 7 weeks
measure: VO2max (maximal aerobic capacity)
timeFrame: 7 weeks
measure: Rate of force development
timeFrame: 7 weeks
measure: Muscular strength (1RM)
timeFrame: 7 weeks
measure: Muscular endurance
timeFrame: 7 weeks
measure: Physical activity
timeFrame: Baseline (before intervention), 4 and 7 weeks.
measure: Health-Related Quality of Life
timeFrame: 7 weeks
Other outcomes:
Locations:
city: Trondheim
country: Norway
facility: Department of Circulation and Medical Imaging
Study officials:
affiliation: Norwegian University of Science and Technology
name: Øystein Risa
role: STUDY_DIRECTOR
References: