Clinical trial NCT01496209: REgenerative CardiOsphere iNjection to STRengthen dysfUnCTional Hearts
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: PHASE1
Conditions: Ischemic Cardiomyopathy
Chronic Ischemic Cardiomyopathy
Keywords: Infarction
Myocardial Infarction
Ventricular Dysfunction, Left
Heart Disease
Cardiovascular Disease
Chronic Ischemia
Lead sponsor: Cedars-Sinai Medical Center
Sponsor class: OTHER
First posted: 2011-12-21
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: A double blinded and placebo-controlled, dose escalation, single-center safety and preliminary efficacy study of cardiospheres delivered via NOGA MYOSTAR injection catheter in subjects with chronic ischemic cardiomyopathy. The objective is to achieve and document myocardial regeneration in patients with chronic scar.


Eligibility criteria: Inclusion Criteria:

* Adults with ischemic cardiomyopathy (EF \>10 and \<40% by functional imaging \[ECHO, CT, MRI, contrast ventriculography\])
* Symptomatic heart failure of NYHA Class 2 or 3
* History of prior remote (\>3 mo) myocardial infarction and/or documented obstructive coronary artery disease with corresponding dysfunctional segments by functional imaging
* Age \> 18 years
* Ability to provide informed consent and follow-up with protocol procedures

Exclusion Criteria:

* Documented myocardial infarction within 3 months (120 days)
* Known or suspected left ventricular thrombus
* Non-cardiovascular disease with life expectancy of \< 3 years
* Absence of significant gadolinium-enhanced scar (\>10% of LV mass) at baseline MRIc
* Positive panel-reactive antibodies (PRA)
* Need for further revascularization clinically indicated at the time the patient is assessed for participation in the clinical trial. This will be determined by a cardiologist who is not an investigator in the clinical trial. No further revascularization may be indicated by no arteries with significant stenosis, the location, and extent of any stenosis may not be suitable for angioplasty, the distal vessels may not be suitable for placement of bypass grafts, and/or the patient declines angioplasty or bypass surgery.
* NYHA IV heart failure
* History of aortic stenosis/insufficiency
* Requirement for chronic immunosuppressive therapy
* Participation in an on-going protocol studying an experimental drug or device
* Diagnosis of congenital or genetically-transmitted cardiomyopathy
* Current alcohol or drug abuse because of anticipated difficulty in complying with protocol-related procedures
* Pregnancy or child-bearing potential without use of effective contraception. Men intending to "father" children are also excluded.
* Human Immunodeficiency virus infection
* Viral hepatitis
* Uncontrolled diabetes and/or hemoglobin A1C \> 8.5%
* Abnormal liver function (SGPT \> 3 times the upper reference range) and/or hematology (hematocrit \<25%, WBC \<3000, Platelets \<100,000) studies without a reversible, identifiable cause
* Ventricular tachycardia or fibrillation not associated with an acute ischemic episode
* Canadian Cardiovascular Society Angina Class 3 or 4
* History of cardiac tumor or cardiac tumor demonstrated or suspected on MRI other imaging modality
* Previous stem cell therapy/treatment
* Individuals who are not fluent in English

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Los Angeles
country: United States
facility: Cedars-Sinai Medical Center
state: California
Study officials:
affiliation: Cedars-Sinai Medical Center, Heart Institute
name: Eduardo Marban, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References: