Clinical trial NCT06591975: The Relationship Between Upper Extremity Function and Balance and Functional Mobility in Parkinson's Disease
Official title: Investigation of the Relationship Between Upper Extremity Function and Balance and Functional Mobility in Parkinson's Disease
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Parkinson Disease
Keywords: parkinson disease
upper extremity
balance
mobility
Lead sponsor: Gazi University
Sponsor class: OTHER
First posted: 2024-09-19
Enrollment: 26
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Patients referred with a diagnosis of Parkinson's Disease (PD) to the Department of Physiotherapy and Rehabilitation at the University by a specialist physician from the Department of Neurology at the University Medical Faculty Research and Application Hospital will be included in the study

Brief summary: Parkinson's Disease (PD) is the second most common neurodegenerative disease, affecting 2-3% of the population aged 65 and over, characterized by the loss of dopaminergic neurons. The basal ganglia play a significant role in the pathogenesis of PD. The lesions of the basal ganglia impair the ability of patients to perform complex, goal-oriented, and skill-requiring movements. Consequently, motor symptoms such as bradykinesia, rigidity, hypokinesia, and tremor, which are progressively worse, are added to the clinical picture of the disease.

These symptoms, which cause movement and activity limitations in individuals with PD, also affect upper extremity functions, balance, and functional mobility. Impairment of upper extremity functions, commonly seen from the early stages of the disease, can affect many basic activities of daily living, including buttoning clothes, tying shoelaces, sewing, writing, eating, and using various modern devices. Balance and mobility disorders are among the most debilitating features of the disease, as they lead to the deterioration of physical functions in PD. Balance and mobility issues in PD are identified as key determinants of the increasing fear of falling and the resulting decline in quality of life. Various factors such as rigidity, bradykinesia, impaired postural adjustments, and decreased sensory integration contribute to the negative impact on balance and mobility in individuals with PD.

Proper balance and mobility performance are achieved through synergistic control during both dynamic and static postures between proximal body segments such as the trunk, spine, and pelvis. This contributes to the mobility of distal segments and the functionality of the upper extremities. Additionally, the contribution of upper extremity functions to balance and mobility has been demonstrated in healthy populations. Current literature also reveals that treatment programs targeting the upper extremities can improve mobility and balance, especially in neurological patient populations.

In conclusion, balance and mobility disorders in Parkinson's disease can reduce proximal stability and affect hand dexterity. This study aims to examine the relationship between hand dexterity, balance, and functional mobility in individuals with PD.

Detailed description: According to the sample size calculation, at least 26 diagnosed PD will be included. Participants' demographic characteristics will be taken initially and the stage will be recorded according to the Hoehn and Yahr Scale. Then, upper extremity functions, balance, and functional mobility will be evaluated.

Eligibility criteria: Inclusion Criteria:

* Having accepted participation in the study after being provided with detailed information about the research
* Having been diagnosed with only Parkinson's Disease by a specialist physician
* Having a Standardized Mini-Mental Test score greater than 24
* Being in stages 1 to 3 according to the Hoehn and Yahr Scale

Exclusion Criteria:

* Having any vision, hearing, or perceptual issues that could affect the research outcomes
* Having an orthopedic problem in the upper extremity that could impact hand dexterity, balance, or mobility
* Having a cardiovascular, pulmonary, or hormonal disorder

Primary outcomes:
measure: The Nine-Hole Peg Test
timeFrame: Assessment will be conducted immediately after enrollment.
measure: The Berg Balance Scale
timeFrame: Assessment will be conducted immediately after enrollment.
measure: The Timed Up and Go Test
timeFrame: Assessment will be conducted immediately after enrollment.
measure: The timed 360° turn test
timeFrame: Assessment will be conducted immediately after enrollment.
measure: Functional Reach Test
timeFrame: Assessment will be conducted immediately after enrollment.
Secondary outcomes:
Other outcomes:
Locations:
city: Sivas
country: Turkey
facility: Sivas Cumhuriyet University
Study officials:
References:
citation: Milosevic M, McConville KM, Masani K. Arm movement improves performance in clinical balance and mobility tests. Gait Posture. 2011 Mar;33(3):507-9. doi: 10.1016/j.gaitpost.2010.12.005. Epub 2011 Jan 11.
citation: Kalkan AC, Kahraman T, Ugut BO, Colakoglu BD, Genc A. A comparison of the relationship between manual dexterity and postural control in young and older individuals with Parkinson's disease. J Clin Neurosci. 2020 May;75:89-93. doi: 10.1016/j.jocn.2020.03.018. Epub 2020 Mar 20.