Clinical trial NCT04758754: Active and Passive Exercise Training in Improving Vascular Function: Local vs Systemic Vascular Effect.
Official title: Active and Passive Exercise Training in Improving Vascular Function: Local vs Systemic Vascular Effect
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Aerobic Exercise
Stretching
Lead sponsor: University of Milan
Sponsor class: OTHER
Collaborators: name: Universita di Verona
First posted: 2021-02-17
Enrollment: 36
Sex: ALL
Minimum age (years): 20
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Three arms: 1) active exercise training (single leg knee extension); 2) passive exercise training (passive static training); 3) controls (no training)
Primary purpose: BASIC_SCIENCE

Brief summary: Maintaining an adequate state of vascular function is an important element for the maintenance of cardiovascular well-being. Several training plans involving both active and passive engagement by the muscles have been proposed with the aim of improving vascular function. At local level, i.e., at the level of the arteries that supply the muscles directly involved in training, significant improvements in vascular function have been found. These improvements are more noticeable after active training than with a passive training regimen, such as passive static stretching. On the contrary, at the systemic level the effects of active or passive training are less clear and, above all, it is not evident whether there is a difference in the effects induced at the level of vascular function in arteries supplying muscles not directly involved in training. The aim of the study is to clarify the local and systemic effect of an active training protocol (single leg knee extension, SLKE) and of a passive training protocol (passive static stretching training, PST) applied to the lower limbs lasting 8 weeks on the local (femoral artery) and systemic (brachial artery) vascular function.


Eligibility criteria: Inclusion Criteria:

-

Exclusion Criteria:

* neurological, vascular and musculoskeletal disorders of the lower and upper limbs;
* being on pharmacological therapy related to either neural and/or vascular response, including hormonal contraceptives and oral supplements;
* being a current or former smoker;
* having an irregular menstrual cycle (26 to 35 days) up to 3 months before the beginning of the study;
* contraindications to joint mobilization; regular involvement in a SLKE or PS training programme.

Primary outcomes:
measure: Change from baseline in brachial artery flow mediated dilation
timeFrame: Change from baseline in percentage flow mediated dilation at 8 weeks
Secondary outcomes:
measure: Change from baseline in femoral artery delta blood flow
timeFrame: Change from baseline in Delta Blood Flow at 8 weeks
Other outcomes:
Locations:
city: Milano
country: Italy
facility: Department of Biomedical Science for Health
Study officials:
References:
citation: Ce E, Venturelli M, Bisconti AV, Longo S, Pedrinolla A, Coratella G, Schena F, Esposito F. Long-Term Passive Leg Stretch Improves Systemic Vascular Responsiveness as Much as Single-Leg Exercise Training. Med Sci Sports Exerc. 2022 Mar 1;54(3):475-488. doi: 10.1249/MSS.0000000000002811.