Clinical trial NCT04946877: Clinical Study of Comorbidities of Attention Deficit Hyperactivity in Children and Adolescents.
Official title: Clinical Study of Comorbidities of Attention Deficit Hyperactivity in Children and Adolescents.
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Attention Deficit Hyperactivity Disorder
Keywords: ADHD,comorbidities
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2021-07-01
Enrollment: 200
Sex: ALL
Minimum age (years): 6
Maximum age (years): 17
Standard ages: CHILD
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Case group will include 100 ADHD patients; will be taken from outpatient clinic of child and adolescence psychiatry of Assiut university hospitals.

Control group will include 100 normal children; they will be selected from neurology clinic complaining from minor neurological complaint e.g : headache, will match with the case group for age, sex and educational level.

Brief summary: Determine the frequency of psychiatric and neurological comorbidities in children and adolescence diagnosed with ADHD.

Detailed description: ADHD is a common neurodevelopmental disorder characterized by hyperactivity, impulsivity, and inattention .ADHD is more often a complex disorder with a high rate of associated co-morbid conditions. Co-morbid conditions are prevalent among people with ADHD and increase its burden and complexity of management.Children with ADHD are at a higher risk than children without ADHD for developing other psychiatric disorders .Motor skill problems and Neurological soft signs are found in many neuropsychiatric conditions .NSS have been associated with inattention and behaviour difficulties for decades. Some researchers argue that these signs should be included in the diagnosis of ADHD .

Eligibility criteria: Inclusion Criteria:

* Age: 6-17 years.
* Sex: both sexes will be included in the study.
* IQ≥70.

Exclusion Criteria:

* Age: less than 6 years or more than 17 years.
* IQ\<70.
* Patients with major neurological deficits, cerebral palsy and uncontrolled epilepsy.
* Patients with major psychiatric disorders e.g schizophrenia spectrum disorder.
* Patient who refusing to participate in the study or their caregiver refusing to give informed consent.

Primary outcomes:
measure: Determine psychiatric comorbidities in children and adolescents with ADHD using Mini international neuropsychiatric interview for children and adolescents (M.I.N.I. Kid).
timeFrame: baseline
Secondary outcomes:
measure: determinate presence of soft neurological sign in children and adolescents with ADHD using Cambridge neurological inventory.
timeFrame: baseline
Other outcomes:
Locations:
Study officials:
References:
citation: Gillberg C, Gillberg IC, Rasmussen P, Kadesjo B, Soderstrom H, Rastam M, Johnson M, Rothenberger A, Niklasson L. Co-existing disorders in ADHD -- implications for diagnosis and intervention. Eur Child Adolesc Psychiatry. 2004;13 Suppl 1:I80-92. doi: 10.1007/s00787-004-1008-4.
citation: Faraone SV, Asherson P, Banaschewski T, Biederman J, Buitelaar JK, Ramos-Quiroga JA, Rohde LA, Sonuga-Barke EJ, Tannock R, Franke B. Attention-deficit/hyperactivity disorder. Nat Rev Dis Primers. 2015 Aug 6;1:15020. doi: 10.1038/nrdp.2015.20.
citation: Jensen CM, Steinhausen HC. Comorbid mental disorders in children and adolescents with attention-deficit/hyperactivity disorder in a large nationwide study. Atten Defic Hyperact Disord. 2015 Mar;7(1):27-38. doi: 10.1007/s12402-014-0142-1. Epub 2014 Jun 19.