Clinical trial NCT05681351: CORE-OLE: A Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Participants With Severe Hypertriglyceridemia (SHTG)
Official title: An Open-Label Extension Study of Olezarsen (ISIS 678354) Administered Subcutaneously to Patients With Severe Hypertriglyceridemia (SHTG)
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE3
Conditions: Severe Hypertriglyceridemia
Keywords: ISIS 678354
Olezarsen
Lead sponsor: Ionis Pharmaceuticals, Inc.
Sponsor class: INDUSTRY
First posted: 2023-01-12
Enrollment: 800
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the safety and tolerability of olezarsen in participants with SHTG.

Detailed description: This is a multi-center, open-label extension (OLE) study of approximately 800 participants with SHTG who would be rolled over from studies ISIS 678354-CS5 (NCT05079919) or ISIS 678354-CS6 (NCT05552326). Day 1 of this study may be same as the Week 53 visit of either ISIS 678354-CS5 or ISIS 678354-CS6, as applicable. Participants will receive olezarsen during the 157-week treatment period. The study will include a 31-day qualification Period, a 157-week treatment period, and a 13-week post-treatment period.

Eligibility criteria: Key Inclusion Criteria:

* Satisfactory completion of either ISIS 678354-CS5 or ISIS 678354-CS6 with an acceptable safety profile, per Investigator judgment. Satisfactory completion requires that the patient did not terminate early from treatment.
* Participants must be on a stable regimen of lipid-lowering therapy that should adhere to standard of care (SOC) per local guidelines. A patient may be eligible if their regimen of lipid-lowering therapy has been changed recently, provided that lipid lowering medications are optimized and stabilized for at least 4 weeks prior to the end of the Qualification Period of this OLE study; ideally, such changes are initiated after Week 53 of the index study (ISIS 678354-CS5 or CS6).
* A patient may re-enroll in the study after having completed the study when the Treatment Period was 53 weeks, if the patient satisfactorily completed the study with an acceptable safety profile, per Investigator judgment. In the case of re-enrollment, there is no limit on the time gap between completion of treatment under the previous protocol and dosing upon re-enrollment (i.e., may exceed 17 weeks between doses).

Key Exclusion Criteria:

• Have any new condition or worsening of existing condition which in the opinion of the Investigator would make the participant unsuitable for enrollment, or could interfere with the participant participating in or completing the study, including need for treatment with disallowed medications, or need to change the required stable regimen as per either ISIS 678354-CS5 or ISIS 678354-CS6 study entry criteria. It is acceptable to adjust a regimen of lipid-lowering therapy as described in the second Key Inclusion Criterion above, and it is acceptable to adjust or stop lipid-lowering therapy at or after Week 13 per Investigator judgment.

NOTE: Other Inclusion/Exclusion criteria may apply.

Primary outcomes:
measure: Proportion of Participants With Change in Clinical Laboratory Values From Baseline to Week 53, From Baseline to Week 105, and From Baseline to Week 157
timeFrame: Baseline up to Week 157
measure: Proportion of Participants Who Experience Adverse Events (AEs)
timeFrame: Baseline up to Week 157
measure: Proportion of Participants Who Use Concomitant Medications
timeFrame: Baseline up to Week 157
Secondary outcomes:
Other outcomes:
Locations:
city: Los Angeles
country: United States
facility: LA Universal Research Center, Inc.
state: California
city: San Diego
country: United States
facility: University of California, San Diego (UCSD)
state: California
city: Tarzana
country: United States
facility: Metabolic Institute of America
state: California
city: Boca Raton
country: United States
facility: Excel Medical Clinical Trials
state: Florida
city: Greenacres City
country: United States
facility: Finlay Medical Research
state: Florida
city: Miami
country: United States
facility: Columbus Clinical Services, LLC
state: Florida
city: Miami
country: United States
facility: Finlay Medical Research
state: Florida
city: Miramar
country: United States
facility: Innovia Research Center, Inc.
state: Florida
city: North Miami Beach
country: United States
facility: Harmony Clinical Research, Inc.
state: Florida
city: Tampa
country: United States
facility: R & B Medical Center LLC
state: Florida
city: Tampa
country: United States
facility: VICIS Clinical Research
state: Florida
city: Tampa
country: United States
facility: JSV Clinical Research Study, Inc.
state: Florida
city: Trinity
country: United States
facility: Bayside Clinical Research
state: Florida
city: Columbus
country: United States
facility: Centricity Research
state: Georgia
city: Columbus
country: United States
facility: IACT Health
state: Georgia
city: Oak Brook
country: United States
facility: Affinity Health
state: Illinois
city: Carmel
country: United States
facility: St. Vincent Medical Group, Inc.
state: Indiana
city: Kansas City
country: United States
facility: University of Kansas Medical Center (KUMC)
state: Kansas
city: Lexington
country: United States
facility: The Research Group of Lexington, LLC
state: Kentucky
city: Louisville
country: United States
facility: Louisville Metabolic and Atherosclerosis Research Center (L-MARC)
state: Kentucky
city: Bossier City
country: United States
facility: Grace Research, LLC
state: Louisiana
city: Towson
country: United States
facility: IRC Clinics
state: Maryland
city: Boston
country: United States
facility: Massachusetts General Hospital Heart Center
state: Massachusetts
city: Ann Arbor
country: United States
facility: University of Michigan- Endocrinology & Metabolism
state: Michigan
city: Flint
country: United States
facility: Aa Mrc, Llc
state: Michigan
city: Saint Louis
country: United States
facility: Washington School of Medicine
state: Missouri
city: Lincoln
country: United States
facility: Bryan Medical Center
state: Nebraska
city: Las Vegas
country: United States
facility: Palm Research Center, Inc.
state: Nevada
city: Union City
country: United States
facility: Hudson County Clinical Trials Research Center
state: New Jersey
city: Brooklyn
country: United States
facility: Modern Medical
state: New York
city: Mineola
country: United States
facility: NYU Langone Health
state: New York
city: New York
country: United States
facility: Langone Medical Center
state: New York
city: New York
country: United States
facility: Vagelos College of Physicians and Surgeons of Columbia University
state: New York
city: Orchard Park
country: United States
facility: Orchard Park Family Practice
state: New York
city: Charlotte
country: United States
facility: The Presbyterian Hospital DBA Novant Health Heart and Vascular Institute
state: North Carolina
city: Greensboro
country: United States
facility: Kenneth Hilty
state: North Carolina
city: Lenoir
country: United States
facility: Clinical Trials of America, LLC
state: North Carolina
city: Winston-Salem
country: United States
facility: Lexington
state: North Carolina
city: Columbus
country: United States
facility: The Ohio State University
state: Ohio
city: Edmond
country: United States
facility: Central Oklahoma Early Detection Center
state: Oklahoma
city: Tulsa
country: United States
facility: Oklahoma Heart Institute
state: Oklahoma
city: Philadelphia
country: United States
facility: University of Pennsylvania
state: Pennsylvania
city: Charleston
country: United States
facility: Medical University of South Carolina
state: South Carolina
city: Little River
country: United States
facility: Walker Family Care
state: South Carolina
city: Rapid City
country: United States
facility: Monument Health Clinical Research
state: South Dakota
city: Rapid City
country: United States
facility: Health Concepts
state: South Dakota
city: Chattanooga
country: United States
facility: Chattanooga Research & Medicine, PLLC
state: Tennessee
city: Jackson
country: United States
facility: The Jackson Clinic
state: Tennessee
city: Dallas
country: United States
facility: University of Texas Southwestern
state: Texas
city: Houston
country: United States
facility: Juno Research
state: Texas
city: Houston
country: United States
facility: Pioneer Research Solutions
state: Texas
city: Lampasas
country: United States
facility: FMC Science
state: Texas
city: McAllen
country: United States
facility: DCT- McAllen Primary Care, LLC
state: Texas
city: McKinney
country: United States
facility: Texas Institute of Cardiology
state: Texas
city: Mesquite
country: United States
facility: SMS Clinical Research, LLC
state: Texas
city: Mesquite
country: United States
facility: Southern Endocrinology Associates
state: Texas
city: Odessa
country: United States
facility: Permian Research Foundation
state: Texas
city: San Antonio
country: United States
facility: Diabetes & Glandular Disease Clinic, P.A.
state: Texas
city: Webster
country: United States
facility: Tranquil Clinical and Research Consulting Services
state: Texas
city: Manassas
country: United States
facility: Manassas Clinical Research
state: Virginia
city: Norfolk
country: United States
facility: York Clinical Research
state: Virginia
city: Morgantown
country: United States
facility: WVU Heart and Vascular Institute
state: West Virginia
city: Buenos Aires
country: Argentina
facility: CIPREC
city: Buenos Aires
country: Argentina
facility: Fundacion Favaloro
city: Buenos Aires
country: Argentina
facility: Centro Medico Dra. Laura Maffei-Investigacion Clinica Aplicad
city: Buenos Aires
country: Argentina
facility: Glenny Corp SA
city: Córdoba
country: Argentina
facility: Instituto Medico DAMIC
city: Villa María
country: Argentina
facility: Clinica FUSAVIM Privada
city: Saint Leonards
country: Australia
facility: Royal North Shore Hospital
state: New South Wales
city: Adelaide
country: Australia
facility: Royal Adelaide Hospital
city: Camperdown
country: Australia
facility: Royal Prince Alfred Hospital
city: Clayton
country: Australia
facility: Monash Medical Centre
city: Woolloongabba
country: Australia
facility: Dr Heart Pty Ltd
city: Hasselt
country: Belgium
facility: Jessa Ziekenhuis
city: Leuven
country: Belgium
facility: Universitaire Ziekenhuizen Leuven
city: Campinas
country: Brazil
facility: Centro Especializado em Cardiologia
city: Curitiba
country: Brazil
facility: Nucleo de Pesquisa Clinica S/S
city: Fortaleza
country: Brazil
facility: Hospital Universitario Walter Cantidio- UFC
city: São Paulo
country: Brazil
facility: Instituto do Coracao (InCor) do Hospital das Clinicas da FMUSP
city: São Paulo
country: Brazil
facility: CPQuali Pesquisa Clinica Ltda.
city: Blagoevgrad
country: Bulgaria
facility: MHAT- Blagoevgrad AD
city: Burgas
country: Bulgaria
facility: Medical Center Doctor Staykov EOOD
city: Dimitrovgrad
country: Bulgaria
facility: Medical Center Diamedical 2013 OOD
city: Gabrovo
country: Bulgaria
facility: MHAT
city: Haskovo
country: Bulgaria
facility: MHAT Haskovo AD
city: Pazardzhik
country: Bulgaria
facility: Multiprofile Hospital for Active Treament Pazardzhik, Cardiology Department
city: Plovdiv
country: Bulgaria
facility: SBAL "Special Medic" Ltd.
city: Plovdiv
country: Bulgaria
facility: UHMAT Kaspela Ltd
city: Plovdiv
country: Bulgaria
facility: University Multiprofile Hospital for Active Treatment Pulmed, Clinic of Endocrinology
city: Ruse
country: Bulgaria
facility: Medical Center Rusemed EOOD
city: Ruse
country: Bulgaria
facility: UMHAT Kanev AD
city: Sliven
country: Bulgaria
facility: DCC-1 Sliven Ltd.
city: Smolyan
country: Bulgaria
facility: Medical Center Smolyan Clinical Research OOD
city: Sofia
country: Bulgaria
facility: Medical Center for Specialized Medical Help in Cardiovascular Diseases OOD
city: Sofia
country: Bulgaria
facility: UMHAT Tsaritsa Yoanna ISUL- Clinic of Cardiology
city: Sofia
country: Bulgaria
facility: Medical Center Endomedical
city: Sofia
country: Bulgaria
facility: Medical Center Kalimat EOOD
city: Sofia
country: Bulgaria
facility: MC Doctor Kalchev OOD
city: Sofia
country: Bulgaria
facility: Medical Centre Synexus Sofia
city: Sofia
country: Bulgaria
facility: UMHAT Sofiamed
city: Sofia
country: Bulgaria
facility: MHAT Silven to MMA Sofia
city: Stara Zagora
country: Bulgaria
facility: Clinical of Cardiology
city: Stara Zagora
country: Bulgaria
facility: Medical Center Zara-Med
city: Varna
country: Bulgaria
facility: Diagnostic Consultative Center Equita (DCC Equita)
city: Varna
country: Bulgaria
facility: Specialized Hospital for Active Treatment of Cardiology
city: Veliko Tarnovo
country: Bulgaria
facility: Medical Centre "Nevromedics" EOOD
city: Sarnia
country: Canada
facility: Bluewater Clinical Research Group, Inc.
state: Ontario
city: Toronto
country: Canada
facility: Canadian Phase Onward Inc.
state: Ontario
city: Chicoutimi
country: Canada
facility: Ecogene-21
state: Quebec
city: Québec
country: Canada
facility: Clinique des Maladies Lipidiques de Quebec Inc.
state: Quebec
city: Montréal
country: Canada
facility: Institut de Recherches Cliniques de Montreal
city: Toronto
country: Canada
facility: Toronto General Hospital
city: Brandýs Nad Labem
country: Czechia
facility: MEDICUS SERVICES s.r.o.
city: Hradec Králové
country: Czechia
facility: University Hospital Hradec Králové
city: Louny
country: Czechia
facility: KardioBusak s.r.o.
city: Náchod
country: Czechia
facility: EDUMED s.r.o.
city: Ostrava
country: Czechia
facility: Fakultni nemocnice Ostrava
city: Prague
country: Czechia
facility: Vseobecna fakultni nemocnice
city: Prague
country: Czechia
facility: Endokrinologie Cerny Most s.r.o.
city: Praha
country: Czechia
facility: Fakultni Nemocnice v Motole
city: Praha
country: Czechia
facility: Praha Poliklinika Hurka
city: Příbram
country: Czechia
facility: Milan Kvapil s.r.o.
city: Teplice
country: Czechia
facility: AeskuLab k.s
city: Uherské Hradiště
country: Czechia
facility: MU Dr. Nina Zemkova s.r.o. Interni Ambulance
city: Aalborg
country: Denmark
facility: Aalborg University Hospital
city: Aarhus
country: Denmark
facility: Aarhus Universitet Hospital
city: Esbjerg
country: Denmark
facility: Esbjerg Hospital
city: Viborg
country: Denmark
facility: Viborg Regional Hospital
city: Turku
country: Finland
facility: Turku University Hospital
city: Bron
country: France
facility: Louis Pradel Hospital
city: Dijon
country: France
facility: Chu Dijon Bourgogne
city: Marseille
country: France
facility: Hôpitaux de Marseille
city: Montpellier
country: France
facility: Hopital Lapeyronie
city: Paris
country: France
facility: AP-HP Hopital Pitie-Salpetriere
city: Saint-Herblain
country: France
facility: CHU de Nantes - Hôpital Nord Laennec
city: Strasbourg
country: France
facility: CHRU de Strasbourg
city: Valenciennes
country: France
facility: Groupement de Cooperation Sanitaire (GCS) ESLAN - Polyclinique Vauban
city: Vénissieux
country: France
facility: GHM les Portes du Sud
city: Berlin
country: Germany
facility: Charite- Universitaetsmedizin Berlin
city: Dresden
country: Germany
facility: Universitaetsklinikum Carl Gustav Carus
city: Koeln
country: Germany
facility: Universitaetsklinikum Koeln
city: Witten
country: Germany
facility: Forschungszentrum Ruhr
city: Athens
country: Greece
facility: Evangelismos General Hospital Athens
city: Athens
country: Greece
facility: Hygeia Hospital
city: Baja
country: Hungary
facility: Lausmed Kft
city: Balatonfüred
country: Hungary
facility: DRC Gyógyszervizsgáló Központ Korlátolt felelősségű társaság Balatonfüred
city: Budapest
country: Hungary
facility: Obudai Egeszsegugyyi Centrum
city: Debrecen
country: Hungary
facility: Debreceni Egyetem Klinikai Központ
city: Miskolc
country: Hungary
facility: Rakoczi Ferenc Korhaz
city: Nyíregyháza
country: Hungary
facility: Dr. Vasas Szilard Haziorvosi Rendelo
city: Nyíregyháza
country: Hungary
facility: Kardiologia Szakrendeles
city: Székesfehérvár
country: Hungary
facility: Fejer Megyei Szent Gyorgy Egyetemi Oktato Korhaz
city: Mangalore
country: India
facility: Vinaya Hospital and Research Centre
city: Be'er Sheva
country: Israel
facility: Soroka Medical Center
city: Haifa
country: Israel
facility: Bnai Zion Medical Center
city: Haifa
country: Israel
facility: The Lady Davis Carmel Medical Center
city: Jerusalem
country: Israel
facility: Shaare Zedek Medical Center
city: Petach Tikva
country: Israel
facility: Rabin Medical Center
city: Ramat Gan
country: Israel
facility: The Chaim Sheba Medical Center
city: Reẖovot
country: Israel
facility: Kaplan Medical Center
city: Tel Aviv
country: Israel
facility: Tel Aviv Sourasky Medical Center
city: Bergamo
country: Italy
facility: Azienda Socio Sanitaria Territoriale Papa Giovanni XXII
city: Bologna
country: Italy
facility: Policlinico di Sant'Orsola
city: Caserta
country: Italy
facility: Azienda Ospedaliera di Rilievo Nazionale e di Alta Specializzazione "Sant' Anna e San Sebastiano" di Caserta
city: Milano
country: Italy
facility: Ospdale E. Bassini
city: Milano
country: Italy
facility: Asst Grande Ospedale Metropolitano Niguarda
city: Napoli
country: Italy
facility: Azienda Ospedaliera Universitaria Federico II
city: Palmero
country: Italy
facility: Azienda Ospedaliera Universitaria Policlinico
city: Rome
country: Italy
facility: Department of Translational and Precision Medicine
city: Kaunas
country: Lithuania
facility: Klinikiniai Sprendimai, UAB
city: Kaunas
country: Lithuania
facility: Saules Seimos Medicinos Centras
city: Klaipėda
country: Lithuania
facility: Kardiologijos ir reabilitacijos klinika, UAB
city: Kuala Lumpur
country: Malaysia
facility: University Malaya Medical Centre (UMMC)
city: Pulau Pinang
country: Malaysia
facility: Pulau Pinang Hospital
city: Chihuahua
country: Mexico
facility: Scientia Investigacion Clinical Sc
city: Mexico City
country: Mexico
facility: Clinstile, S.A. de C.V.
city: Mexico City
country: Mexico
facility: Centro de Investigacion Cardiometabolica S.C.
city: Amsterdam
country: Netherlands
facility: Academic Medical Center
city: Apeldoorn
country: Netherlands
facility: Gelre Ziekenhuizen
city: Arnhem
country: Netherlands
facility: Ziekenhuis Rijnstate
city: Dirksland
country: Netherlands
facility: Het Van Weel-Bethesda Ziekenhuis
city: Ede
country: Netherlands
facility: Ziekenhuis Gelderse Vallei
city: Hoogeveen
country: Netherlands
facility: Bethesda Diabetes Research Center
city: Nijmegen
country: Netherlands
facility: Radboud UMC
city: Rotterdam
country: Netherlands
facility: Erasmus MC
city: Utrecht
country: Netherlands
facility: University Medical Center Utrecht
city: Zwijndrecht
country: Netherlands
facility: Albert Schweitzer Ziekenhuis
city: Auckland
country: New Zealand
facility: New Zealand Clinical Research
city: Wellington
country: New Zealand
facility: Edgar Diabetes and Obesity Research Centre
city: Oslo
country: Norway
facility: The Lipid Clinic (Oslo University Hospital)
city: Gdańsk
country: Poland
facility: Uniwersytecki Centrum Kliniczne, I Klinika Kardiologii
city: Józefów
country: Poland
facility: Biokinetica Spolka Akcujna
city: Katowice
country: Poland
facility: Centrum Medyczne Salvia
city: Lublin
country: Poland
facility: Clinical Best Solutions
city: Lublin
country: Poland
facility: ETG Lublin
city: Poznań
country: Poland
facility: Centrum Zdrowia Metabolicznego Pawel Bogdanski
city: Tarnów
country: Poland
facility: Osrodek Badan Klinicznych Metabolica
city: Warsaw
country: Poland
facility: Clinical Best Solutions Sp. z.o.o. Spolka Komandytowa
city: Wrocław
country: Poland
facility: Przychodnia Futuremeds Wroclaw
city: Zamość
country: Poland
facility: ETG Zamosc
city: Łódź
country: Poland
facility: Instytut Centrum Zdrowia Matki Polki
city: Aveiro
country: Portugal
facility: Hospital Infante D. Pedro
city: Lisboa
country: Portugal
facility: Hospital COF Tejo
city: Lisboa
country: Portugal
facility: Hospital CUF Tejo
city: Porto
country: Portugal
facility: Centro Hospitalar Universitario De Sao Joao
city: Santa Maria Da Feira
country: Portugal
facility: Centro Hospitalar de Entre o Douro e Vouga, E.P.E.
city: Baia Mare
country: Romania
facility: Cardioplus Center SRL
city: Bratislava
country: Slovakia
facility: Ambulancia diabetologicka a poruch latkovej premeny a vyzivy
city: Brezno
country: Slovakia
facility: Kardiologická ambulancia
city: Košice
country: Slovakia
facility: Cardio D&R, S.R.O. Kosice
city: Košice
country: Slovakia
facility: Human-Care s.r.o.
city: Košice
country: Slovakia
facility: Vychodoslovensky Utsav srdcovych a cievnych chorob a.s.
city: Lučenec
country: Slovakia
facility: Interna a diabetologicka ambulancia- IN- DRA- s.r.o.
city: Rožňava
country: Slovakia
facility: Diab sro
city: Svidník
country: Slovakia
facility: Interna SK, s.r.o., Kardiologicka a interna ambulancia
city: Svidník
country: Slovakia
facility: Nemocnica arm. generala L. Svobodu Svidnik, a.s
city: Trebišov
country: Slovakia
facility: Areteus sro
city: Bloemfontein
country: South Africa
facility: Latros International
city: Cape Town
country: South Africa
facility: Medi Clinic Vergelegen
city: Cape Town
country: South Africa
facility: TREAD Research
city: Cape Town
country: South Africa
facility: University of Cape Town
city: Badalona
country: Spain
facility: Hospital Germans Trias i Pujol
city: Barcelona
country: Spain
facility: Hospital Universitario Vall d'Hebron
city: Barcelona
country: Spain
facility: Hospital Clinic De Barcelona
city: Barcelona
country: Spain
facility: Hospital Universitari de Bellvitge
city: Córdoba
country: Spain
facility: Hospital Universitario Reina Sofia
city: Jaén
country: Spain
facility: Hospital Universitario de Jaen
city: La Coruna
country: Spain
facility: Hospital Abente y Lago
city: Madrid
country: Spain
facility: Hospital Universitario 12 de Octubre
city: Málaga
country: Spain
facility: Hospital Universitario Virgen de la Victoria
city: Sabadell
country: Spain
facility: Corporacio Sanitaria Parc Tauli- Hospital de Sabadell
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen Macarena
city: Sevilla
country: Spain
facility: Hospital Virgen del Rocío
city: Tarragona
country: Spain
facility: Hospital Universitari Sant Joan de Reus
city: Valencia
country: Spain
facility: Hospital Clinico Universitario de Valencia
city: Zaragoza
country: Spain
facility: Hospital Universitario Miguel Servet
city: Göteborg
country: Sweden
facility: Sahlgrenska, University Hospital
city: Stockholm
country: Sweden
facility: Karolinska University Hospital Huddinge
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Medical University Ching-Ho Memorial Hospital
city: New Taipei City
country: Taiwan
facility: Mackay Memorial Hospital
city: Taichung
country: Taiwan
facility: Taichung Veterans General Hospital
city: Tainan
country: Taiwan
facility: National Cheng Kung University Hospital
city: Taipei City
country: Taiwan
facility: Shing Kong Wu Ho-Su Memorial Hospital
city: İzmir
country: Turkey
facility: Ege University School of Medicine, Department of Cardiology
city: Konya
country: Turkey
facility: Necmettin Erbakan Universitesi Meram Tip Fakultesi
city: Sulhiye
country: Turkey
facility: Hacettepe Üniversitesi Tıp Fakültesi
city: Woodhurst
country: United Kingdom
facility: Centre for Diabetes, Endocrinology and Metabolic Disease
state: Chatsworth
city: Huddersfield
country: United Kingdom
facility: Huddersfield Royal Infirmary
state: England
city: Blackpool
country: United Kingdom
facility: Waterloo Medical Care
city: Hull
country: United Kingdom
facility: Hull Royal Infirmiry
city: Liskeard
country: United Kingdom
facility: Oak Tree Surgery and Pensilva Health Centre
city: Manchester
country: United Kingdom
facility: Manchester University NHS Foundation Trust
city: Newquay
country: United Kingdom
facility: Newquay Health Centre
city: Poole
country: United Kingdom
facility: The Adam Practice
city: West Bromwich
country: United Kingdom
facility: Sandwell and West Birmingham NHS Trust
Study officials:
References: