Clinical trial NCT01737632: Family-based and Adolescent Residential Drug Treatment
Official title: Family-Based Versus Adolescent Residential Drug Treatment
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Substance Use
Delinquency
Keywords: Adolescents
Residential Treatment
Outpatient Treatment
Substance Abuse
Delinquency
Family Therapy
Multidimensional Family therapy
Lead sponsor: University of Miami
Sponsor class: OTHER
First posted: 2012-11-29
Enrollment: 113
Sex: ALL
Minimum age (years): 13
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: TREATMENT

Brief summary: The fundamental objective of this study is to compare the effectiveness of an intensive in-home family-based treatment, Multidimensional Family Therapy, with a multifaceted residential treatment, Adolescent Residential Treatment, over 4 years post-intake and to delineate the mechanisms of change for each treatment. The study targets dually- diagnosed adolescent drug abusers recommended for residential treatment.

Detailed description: Aim 1: To compare the effectiveness of residential treatment with outpatient, family-based treatment multiple outcomes including substance use, mental health, school functioning, family function and delinquency among dually diagnosed adolescents.

Hypothesis 1. From intake to 2 months, residential treatment will show better outcomes than the family based treatment. Between 2 months and 18 months, family based treatment will show better outcomes than residential. Between 18 months and four years post intake, outpatient family based treatment will maintain its treatment gains, while the residential treatment condition will show an increase in these same symptoms and behaviors.

Aim 2: To examine the relationship between predictors (family, peer, educational/vocational functioning and involvement in post-treatment services), and outcomes (drug use, co-morbid symptoms, and criminal behavior) during the four-year post intake period.

Hypothesis 2a. Family functioning, educational/vocational functioning, and peer relationships measured at discharge will predict drug use, co-morbid symptoms, and criminal behaviors though the four year longer term follow up period.

Hypothesis 2b. Family functioning, educational/vocational functioning, peer relationships, and involvement in post-treatment services during the post treatment period will predict drug use, co-morbid symptoms, and criminal behavior through the longer term follow up period.

Research Question 1. Is the rate of change in family functioning, educational/vocational functioning, peer relationships, and involvement in post-treatment services related to the rate of change in drug use, co-morbid symptoms, and criminal behavior?

Eligibility criteria: Inclusion Criteria:

* Youth between the ages of 13 and 17
* Referred to ATP for residential substance abuse treatment in youth dual diagnosis program
* Dually diagnosed for substance abuse or dependence and at least one of the following co-morbid conditions: major depressive disorder, bipolar disorder, I conduct disorder, oppositional defiant disorder,
* At least one parent or parent-figure can be located at the time of referral.
* Obtain informed consent from a parent or formal guardian and assent from youth to participate in the study.

Exclusion Criteria:

* Have any of the following disorders: Mental Retardation, Eating Disorders, Schizophrenia, or Pervasive Developmental Disorders.
* Current suicidality.

Primary outcomes:
measure: Change in Personal Involvement with Chemicals
timeFrame: Baseline, 2, 4, 12, 18, 24, 36 and 48 months after baseline
measure: Change in substance use consumption
timeFrame: Baseline, 2, 4, 12,18,24,36,48 months after intake
measure: Change in externalizing symptoms
timeFrame: Baseline, 2, 4, 12, 18, 24, 36 and 48 months
measure: Change in delinquency
timeFrame: Intake, 2, 4, 12, 18, 24, 35, 48 months after intake
measure: Change in internalzing symptoms
timeFrame: Intake, 2, 4, 12, 18, 24, 36, 48 months after baseline
Secondary outcomes:
measure: Change in family conflict
timeFrame: Baseline, 2, 4, 12, 18, 24, 36, 48 months after baseline
measure: Change in parenting practices
timeFrame: Baseline, 2, 4, 12, 18, 24,36, 48 months after baseline
measure: Change in family cohesion
timeFrame: Intake, 2, 4, 12, 18, 24, 26, 48 months after intake
Other outcomes:
Locations:
city: Miami
country: United States
facility: University of Miami Miller School of Medicine
state: Florida
city: Miami
country: United States
facility: The Village, Inc.
state: Florida
Study officials:
affiliation: University of Miami
name: Howard A Liddle, EdD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Zavala SK, French MT, Henderson CE, Alberga L, Rowe C, Liddle HA. Guidelines and challenges for estimating the economic costs and benefits of adolescent substance abuse treatments. J Subst Abuse Treat. 2005 Oct;29(3):191-205. doi: 10.1016/j.jsat.2005.06.004.