louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02742961: Impact of Peripheral Nerve Blockade on Outcomes After Total Knee Replacement
Official title: Impact of Peripheral Nerve Blockade on Outcomes After Total Knee Replacement
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pain
Osteoarthritis
Keywords: orthopedics
anesthesiology
nerve block
length of stay
Patient readmission
Lead sponsor: Ottawa Hospital Research Institute
Sponsor class: OTHER
First posted: 2016-04-19
Enrollment: 178214
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All adults having their first total knee replacement during the study period

Brief summary: Pain is common after knee replacement surgery and can impact a variety of patient outcomes. Peripheral nerve blocks provide improved pain control and may improve function. However, their impact on other outcomes is poorly described. Therefore, this comparative effectiveness study will estimate the independent association between nerve blocks and health outcomes after knee replacement surgery.

Detailed description: This retrospective, population-based cohort study will evaluate the comparative effectiveness of peripheral nerve blocks on patient and health system outcomes after elective total knee replacement surgery.

The investigators will develop a non-parsimonious propensity score to control for potential indication bias and confounding in this observational study. Using the propensity score the investigators will match patients who receive a peripheral nerve block to a patient who did not to estimate the independent association of peripheral nerve blocks with our study outcomes.

Eligibility criteria: Inclusion Criteria:

* first primary total knee replacement during the study period

Exclusion Criteria:

* Revision arthroplasty

Primary outcomes:
measure: Hospital length of stay
timeFrame: Day of surgery to day of discharge, or up to 365 days, whichever comes first
Secondary outcomes:
measure: Hospital readmission
timeFrame: The outcome ascertainment window starts on the day of discharge and extends up to 30 days after surgery. Any readmission in this time period will be considered an event.
measure: In-hospital fall
timeFrame: hospital admission
measure: Emergency department visit
timeFrame: The outcome ascertainment window starts on the day of discharge and extends up to 30 days after surgery. Any emergency department visit in this time period will be considered an event.
Other outcomes:
measure: All cause mortality
timeFrame: Day of surgery to 30 days after surgery
Locations:
city: Ottawa
country: Canada
facility: Ottawa Hospital Research Institute
state: Ontario
Study officials:
References:
Clinical trial NCT03606161: Navigated Repetitive Transcranial Magnetic Stimulation in Improving Motor Rehabilitation in Participants With Brain Tumors
Official title: Feasibility of Navigated Repetitive Transcranial Magnetic Stimulation (nrTMS) to Augment the Effects of Motor Rehabilitation in Brain Tumor Patients
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Brain Neoplasm
Lead sponsor: M.D. Anderson Cancer Center
Sponsor class: OTHER
Collaborators: name: National Cancer Institute (NCI)
First posted: 2018-07-30
Enrollment: 32
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: This trial studies how well navigated repetitive transcranial magnetic stimulation works in improving motor rehabilitation in participants with brain tumors. Navigated repetitive transcranial magnetic stimulation may help improve patients' lost motor function after surgery.

Detailed description: PRIMARY OBJECTIVES:

I. Determine feasibility of conducting 10 sessions of navigated repetitive transcranial magnetic stimulation (nrTMS) during the post-surgical rehabilitation time period.

EXPLORATORY OBJECTIVES:

I. Explore the effects of the nrTMS training program on motor recovery. II. Explore changes in cortical activity: electroencephalographic (EEG) activity including event-related potentials (ERPs) and motor evoked potentials (MEPs) will be assessed from baseline to end of treatment (EOT).

OUTLINE:

Between 1-7 days after standard of care surgery, participants undergo 10 nrTMS sessions over 30 minutes each over 3 weeks.

After completion of study, participants are followed up at 3 months.

Eligibility criteria: Inclusion Criteria:

* Patients with brain tumors associated with the motor cortex
* Understand and read English, sign a written informed consent, and be willing to follow protocol requirements
* Eastern Cooperative Oncology Group (ECOG) performance status of 0-2
* Motor impairment must be related to the surgical procedure or the tumor itself (in the opinion of the treating physician)
* Patients who are within 7 days of brain tumor resection associated with the motor cortex
* Eligibility for the nrTMS treatment will be based on motor ability and will be determined postoperatively by the surgeon

Exclusion Criteria:

* Patients who are taking any antipsychotic medications
* Patients who have ever been diagnosed with bipolar disorder or schizophrenia
* Patients with a history of stroke

Primary outcomes:
measure: Intervention adherence
timeFrame: Up to 3 months
Secondary outcomes:
Other outcomes:
measure: Motor recovery
timeFrame: Up to 3 months
measure: Changes in cortical activity
timeFrame: Baseline up to 3 months
Locations:
city: Houston
country: United States
facility: M D Anderson Cancer Center
state: Texas
Study officials:
affiliation: M.D. Anderson Cancer Center
name: Sarah Prinsloo
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00440661: Exploration of the Synovial Fluid Inflammation Mediators Under Diacerhein in Knee Osteoarthritis
Official title: Exploratory Study of Some Synovial Fluid Inflammation Mediatorsunder Diacerhein in Knee Osteoarthritis Patients. Phase IV Study.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Osteoarthritis
Keywords: Osteoarthritis, IL-1
Lead sponsor: Laboratoires NEGMA
Sponsor class: INDUSTRY
First posted: 2007-02-27
Enrollment: 96
Sex: ALL
Minimum age (years): 45
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Some inflammation mediators, notably IL-1, are implied in the joint degeneration phenomena of osteoarthritis. The aim of this study is to confirm in vivo the favourable effect of diacerhein on IL-1 and also to appreciate its effect on other synovial inflammation mediators.


Eligibility criteria: Inclusion Criteria:

* Painful osteoarthritis
* Hydarthrosis (synovial effusion)

Exclusion Criteria:

* large effusion
* severe pathologies
* anti-osteoarthritic treatments

Primary outcomes:
measure: Synovial concentration of IL-1
Secondary outcomes:
measure: Synovial concentration of IL-6
measure: WOMAC
Other outcomes:
Locations:
city: Montreal
country: Canada
facility: Rheumatologic Institut of Montreal
state: Quebec
Study officials:
affiliation: Institut de Rhumatologie de Montreal
name: Jean-Pierre RAYNAULD, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02752061: Potlako: A Programmatic Intervention to Improve Access to Timely Oncology Care
Official title: Potlako: A Programmatic Multi-facility Level Intervention to Improve Access to Timely Oncology Care in Botswana
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Neoplasms
HIV
Healthcare Disparity
Lead sponsor: Harvard School of Public Health (HSPH)
Sponsor class: OTHER
Collaborators: name: Brigham and Women's Hospital
name: Botswana Harvard AIDS Institute Partnership
name: Botswana Ministry of Health
name: Dana-Farber Cancer Institute
First posted: 2016-04-26
Enrollment: 979
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: Diagnostic and treatment delays contribute substantially to disparities in cancer morbidity and mortality between low- and middle- income countries (LMICs) and high-income countries. Individuals present with advanced stage disease resulting in minimal chance for cure or long-term survival.

The Potlako project will implement and evaluate a multifaceted intervention to test the hypothesis that a package of enhanced coordination of care including an electronic messaging, transportation support, and training targeted at generalist clinicians at primary and secondary level facilities, can reduce time to diagnosis and stage at diagnosis for HIV-infected individuals with cancer.


Eligibility criteria: Inclusion Criteria:

* Citizen of Botswana
* Suspected or diagnosed cancer

Exclusion Criteria:

* Involuntary incarceration

Primary outcomes:
measure: Cancer stage
timeFrame: 1 day visit
measure: Time from initial clinic visit with cancer symptom/sign to entry into oncology care
timeFrame: 1 day visit
Secondary outcomes:
Other outcomes:
Locations:
city: Gaborone
country: Botswana
facility: Botswana Harvard AIDS Institute
Study officials:
References:
citation: Tapela NM, Peluso MJ, Kohler RE, Setlhako II, Botebele K, Gabegwe K, Nkele I, Narasimhamurthy M, Mmalane M, Grover S, Barak T, Shulman LN, Lockman S, Dryden-Peterson S. A Step Toward Timely Referral and Early Diagnosis of Cancer: Implementation and Impact on Knowledge of a Primary Care-Based Training Program in Botswana. Front Oncol. 2018 May 29;8:187. doi: 10.3389/fonc.2018.00187. eCollection 2018.
Clinical trial NCT03846661: Nationwide Long-term Outcome Surveillance of Physiomesh® vs. Other Meshes in Laparoscopic Incisional Hernia Repair
Official title: Nationwide Long-term Outcome Surveillance of Physiomesh® vs. Other Meshes in Laparoscopic Incisional Hernia Repair
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hernia, Abdominal
Recurrence
Postoperative Complications
Lead sponsor: Zealand University Hospital
Sponsor class: OTHER
First posted: 2019-02-20
Enrollment: 3338
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Register study
Primary purpose: TREATMENT

Brief summary: The primary aim of the present study was to show how a national clinical register combined with other nationwide administrative registers may serve as a tool for pre- and post-marketing evaluation of new mesh and mesh fixation products for hernia surgery, using Physiomesh® versus other meshes designed for laparoscopic hernia repair as an example.

Detailed description: All adult (≥18 yrs) patients registered in the Danish Hernia Database (DHB) who underwent elective primary laparoscopic incisional hernia repair between January 1st 2010 and December 31st 2016.

To obtain 100% follow-up data from DHB will be combined with administrative data from the Danish National Patient register.

Patients will be followed from initial hernia repair until reoperation for recurrence, death, emigration outside Denmark or end of follow-up (november 2017).

Physiomesh and other mesh repairs will be propensity score matched. Each patient in the Physiomesh® group will be matched with two patients treated with one of the other synthetic meshes. The Propensity score includes age, sex, year of surgery, diagnosis of chronic obstructive pulmonary disease, diagnosis of diabetes, diagnosis of obesity, Charlson comorbidity index and size of hernia defect

The primary outcome: Difference in risk for a reoperation for recurrence between patients operated with Physiomesh® and patients operated with another synthetic mesh designed for laparoscopic repair.

The secondary outcome will be rates of 30-day readmission, 30-day reoperation for complications (excluding hernia recurrence) as well as 30- and 90-day mortality.

Eligibility criteria: Inclusion Criteria:

* All patients registered in the Danish Hernia Database for a laparoscopic incisional hernia repair

Exclusion Criteria:

* If not registered for a laparoscopic incisional hernia repair in the Danish Hernia Database

Primary outcomes:
measure: Re-operation for recurrence rate
timeFrame: up to 84 months
Secondary outcomes:
measure: 30-day readmission rate
timeFrame: 30 day
measure: 30-reoperation for complication rate
timeFrame: 30 day
Other outcomes:
Locations:
city: Køge
country: Denmark
facility: Dept. of surgery, Zealand University Hospital
Study officials:
affiliation: Dept. Surgery, Zealand university Hospital
name: Frederik Helgstrand, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02646761: interACTION: A Portable Joint Function Monitoring and Training System for Remote Rehabilitation Following TKA
Official title: interACTION: A Portable Joint Function Monitoring and Training System for Remote Rehabilitation Following Total Knee Arthroplasty
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Total Knee Arthroplasty
Lead sponsor: University of Pittsburgh
Sponsor class: OTHER
First posted: 2016-01-06
Enrollment: 38
Sex: ALL
Minimum age (years): 40
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine if home-based therapy with monitoring via telemedicine can overcome many barriers to compliance and improve rehabilitation. Patients undergoing total knee arthroplasty will be followed for 10 weeks during their outpatient physical therapy course. Subjects will undergo standard physical therapy or physical therapy paired with InterACTION for 10 weeks.


Eligibility criteria: Inclusion Criteria:

1. Between ages 40 to 80 years of age;
2. Have undergone primary unilateral total knee arthroplasty;
3. Being referred for post-operative outpatient physical therapy;
4. Agree to and able to perform pre-defined exercises that they would normally perform in a physical rehabilitation program.

Exclusion Criteria:

1. Patients with BMI \>40 at the time of surgery;
2. Individuals who are not free of any other co-disability or comorbidity that would specifically impede disallow or otherwise hinder performance of rehabilitation exercises;
3. Individuals who cannot physically receive or understand audio and visual feedback from the joint motion tracking system during or after performance of rehabilitation exercises;
4. Individuals who are discharged post-operatively to a skilled nursing facility instead of to their residence;

Primary outcomes:
measure: Value Was Evaluated as the Ratio of Change in the Activities of Daily Living Scale Score to the Costs of Rehabilitation.
timeFrame: 10 weeks
Secondary outcomes:
measure: Number of Participants That Complied With Rehabilitation Program
timeFrame: 10 weeks
measure: Number of Subjects Satisfied With InterACTION Device
timeFrame: 10 weeks
measure: Performance Based Outcome Measures
timeFrame: 10 weeks
measure: Range of Motion (Extension)
timeFrame: baseline and 10 weeks
measure: Range of Motion (Flexion)
timeFrame: baseline and 10 weeks
Other outcomes:
Locations:
city: Pittsburgh
country: United States
facility: University of Pittsburgh
state: Pennsylvania
Study officials:
References:
citation: Bell KM, Onyeukwu C, Smith CN, Oh A, Devito Dabbs A, Piva SR, Popchak AJ, Lynch AD, Irrgang JJ, McClincy MP. A Portable System for Remote Rehabilitation Following a Total Knee Replacement: A Pilot Randomized Controlled Clinical Study. Sensors (Basel). 2020 Oct 27;20(21):6118. doi: 10.3390/s20216118.
Clinical trial NCT06873061: "The Impact of Digitalization Education Provided to Nursing Students on Their Attitudes Towards Telemedicine"
Official title: Principal Investigator, Doktor Researcher Assistant, Department of Psychiatric Nursing
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Telenursing
Telemedicine
Keywords: telemedicine
telenursing
nursing student
Lead sponsor: Ondokuz Mayıs University
Sponsor class: OTHER
First posted: 2025-03-12
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: A randomized controlled trial (RCT) is a research design in which participants are randomly assigned to either an experimental group or a control group. The experimental group receives a specific intervention or treatment, while the control group receives no intervention or the standard treatment. In this way, the effect of the intervention is assessed. Pre- and post-intervention data are collected, and the differences between the groups are evaluated using statistical analysis. RCT is a reliable method for objectively measuring the effects of an intervention.
Primary purpose: OTHER

Brief summary: This research was conducted as a pre-test post-test design in a randomized controlled study. Participants were given a 5-week telemedicine education related to nursing care, and the changes in students' attitudes toward telemedicine were examined. Digitalization has brought about significant changes in healthcare, and telemedicine applications have enabled nurses to transform patient care. Improving nursing students' knowledge and attitudes toward telehealth is crucial for enhancing the effective use of digital health tools. In this context, the "The Role of Digitalization in Nursing: An Innovative Transformation in Care" training program was designed to assess nursing students' attitudes toward telemedicine applications. The study aims to analyze the impact of the training program by comparing experimental and control groups.


Eligibility criteria: Inclusion Criteria:

* Age 18 or older,
* Currently enrolled as an active student in the Nursing Department,
* A third-year student in the Nursing Department,
* Agreement to participate in the study.

Exclusion Criteria:

* Having hearing or speech impairments,
* Diagnosed with a psychotic disorder,
* Participating in another psychosocial intervention program.

Primary outcomes:
measure: Increase in attitudes towards medicine in the experimental group
timeFrame: five week
Secondary outcomes:
measure: no change in the control group
timeFrame: 5 week
Other outcomes:
Locations:
city: Samsun
country: Turkey
facility: Ondokuz Mayis University
state: Atakum
Study officials:
References:
citation: Ravari, A., Sheikhoshaqi, A., Mirzaei, T., Raeisi, M., Hassanshahi, E., & Kamiab, Z. (2021). Effect of tele-nursing on blood glucose control among the elderly with diabetes: a randomized controlled trial. Evidence-Based Care, 11(2), 54-63.
Clinical trial NCT06229561: Soft Tissue Graft Versus Acellular Dermal Matrix in Preservation of Buccal Plate of Bone
Official title: Soft Tissue Graft Versus Acellular Dermal Matrix in Preservation of Buccal Plate of Bone After Immediate Implant Placement
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
PHASE2
Conditions: Comparative Study
Lead sponsor: Faculty of Dental Medicine for Girls
Sponsor class: OTHER_GOV
First posted: 2024-01-29
Enrollment: 12
Sex: ALL
Minimum age (years): 20
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Comparative study between 2 groups to assess the feasibility of using Acellular dermal matrix vs Soft tissue Graft after immediate implant placement

Detailed description: It was conclude that SCTG is the gold standard for soft tissue augmentation up till now, However ADM can be alternative to autogenous soft tissue graft.

Eligibility criteria: Inclusion Criteria:

Medically free

Exclusion Criteria:

Heavy smoking

Primary outcomes:
measure: Buccal bone thickness
timeFrame: 6 months follow up
Secondary outcomes:
Other outcomes:
Locations:
city: Madīnat Nāşir
country: Egypt
facility: Azhar University
Study officials:
affiliation: No affliction
name: Azhar Journal
role: PRINCIPAL_INVESTIGATOR
References:
citation: Elaskary A, Abdelrahman H, Elfahl B, Elsabagh H, El-Kimary G, Ghallab NA. Immediate Implant Placement in Intact Fresh Extraction Sockets Using Vestibular Socket Therapy Versus Partial Extraction Therapy in the Esthetic Zone: A Randomized Clinical Trial. Int J Oral Maxillofac Implants. 2023 May, Jun;38(3):468-478. doi: 10.11607/jomi.9973.
Clinical trial NCT05680961: Monitoring Movement Disorder Symptoms With a Mobile Medical App on Off-the-shelf Consumer Mobile Devices
Official title: Monitoring Movement Disorder Symptoms With a Mobile Medical App on Off-the-shelf Consumer Mobile Devices
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Parkinson Disease
Keywords: Parkinson's disease
Lead sponsor: Parkinson's & Movement Disorders Center of Maryland
Sponsor class: OTHER
Collaborators: name: New Touch Digital Inc.
First posted: 2023-01-11
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: The study is open to persons 18 years of age and older with a clinical diagnosis of Parkinson's diseases without other neurological diseases.

Brief summary: The purpose of this study is to evaluate whether New Touch Digital (NTD) NeuroRPM software installed on wearable devices can objectively measure and track symptoms in patients with Parkinson's disease.


Eligibility criteria: Inclusion Criteria:

1. Subject is 18 years of age or older
2. Subject is able to provide informed written consent
3. Subject has been clinically diagnosed with Parkinson's Disease
4. Subject is mentally and physically capable of performing tasks on the mobile device and related physical activities herein described

Exclusion Criteria:

1. Inability to give informed consent
2. Presence of additional neurological disease aside from the diseases being studied
3. Inability to understand and follow the directions for the study

Primary outcomes:
measure: NeuroRPM UPDRS predicted score vs. clinical raters' UPDRS
timeFrame: Comparison will be performed upon completion of the study, approximately in 1 year.
Secondary outcomes:
Other outcomes:
Locations:
city: Elkridge
country: United States
facility: Parkinson's & Movement Disorders Center of Maryland
state: Maryland
Study officials:
References: