Clinical trial NCT05505383: The Effect of Backward Walking Training on Balance, Gait and Functional Mobility in Patients With Multiple Sclerosis
Official title: The Effect of Backward Walking Training on Balance, Gait and Functional Mobility in Patients With Multiple Sclerosis Patients
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Multiple Sclerosis
Keywords: multiple sclerosis
backward walking training
balance
gait
functional mobility
Lead sponsor: Saglik Bilimleri Universitesi
Sponsor class: OTHER
Collaborators: name: Ankara University
First posted: 2022-08-17
Enrollment: 22
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Backward walking training can be a useful treatment approach, providing novel balance and gait challenges. It can lead to improve balance, gait and functional mobility in neurologic populations. However, the effect of backward walking training has net been investigated in people with multiple sclerosis.

Detailed description: Multiple sclerosis is a chronic autoimmune disease of the central nervous system. Patients with multiple sclerosis have problems in balance, gait, and functional mobility. This problems can lead to falls, injuries, hospitalization, limited daily living activities, and decreased quality of life. Backward walking is a popular training approach to improve balance, gait, and functional mobility in other neurological disease such as stroke, and Parkinson's disease. Moreover, backward walking performance decreases in multiple sclerosis. However, no study has been performed to determine the effectiveness of backward walking training in multiple sclerosis. Therefore, this study aimed to investigate the effect of backward walking training on balance, gait, and functional mobility in patients with multiple sclerosis.

Eligibility criteria: Inclusion Criteria:

* at least 18 years,
* neurologist-diagnosed Multiple Sclerosis,
* Expanded Disability Status Scale (EDSS) score between 0 and 5.5,
* no MS exacerbation within the last 3 months,
* use of stable medication in the last 3 months,
* not received immunomodulator treatment within the last 6 months,

Exclusion Criteria:

* other neurologic disorder,
* Pregnancy,
* Cardiovascular, orthopedic, or systemic any disease hindering the participation of exercise program

Primary outcomes:
measure: Berg Balance Scale [Time Frame: 10 minutes]
timeFrame: 10 minutes
measure: Four Square Step Test
timeFrame: 15 seconds
measure: Activities-specific Balance Confidence Scale
timeFrame: 2 minutes
measure: 10 Meter Walk Test
timeFrame: 20 seconds
measure: Timed 25-feet Walk Test
timeFrame: 1 minutes
measure: Six Minute Walk Test
timeFrame: 6 minutes
measure: 3-meter Backward Walk Test
timeFrame: 10 seconds
measure: Dynamic Gait Index
timeFrame: 5 minutes
measure: Multiple Sclerosis Walking Scale-12
timeFrame: 2 minutes
measure: Timed Up and Go Test
timeFrame: 15 seconds
Secondary outcomes:
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Ankara University
city: Ankara
country: Turkey
facility: Ankara University
Study officials:
affiliation: Ankara University
name: Canan Yucesan, Prof. Dr.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Wang J, Xu J, An R. Effectiveness of backward walking training on balance performance: A systematic review and meta-analysis. Gait Posture. 2019 Feb;68:466-475. doi: 10.1016/j.gaitpost.2019.01.002. Epub 2019 Jan 3.
citation: Rose DK, DeMark L, Fox EJ, Clark DJ, Wludyka P. A Backward Walking Training Program to Improve Balance and Mobility in Acute Stroke: A Pilot Randomized Controlled Trial. J Neurol Phys Ther. 2018 Jan;42(1):12-21. doi: 10.1097/NPT.0000000000000210.
citation: Choi JY, Son SM, Park SH. A Backward Walking Training Program to Improve Balance and Mobility in Children with Cerebral Palsy. Healthcare (Basel). 2021 Sep 9;9(9):1191. doi: 10.3390/healthcare9091191.
citation: Moon Y, Bae Y. Backward walking observational training improves gait ability in patients with chronic stroke: randomised controlled pilot study. Int J Rehabil Res. 2019 Sep;42(3):217-222. doi: 10.1097/MRR.0000000000000352.
citation: Wang J, Yuan W, An R. Effectiveness of backward walking training on spatial-temporal gait characteristics: A systematic review and meta-analysis. Hum Mov Sci. 2018 Aug;60:57-71. doi: 10.1016/j.humov.2018.05.007. Epub 2018 May 24.
citation: DeMark L, Fox EJ, Spigel PM, Osborne J, Rose DK. Clinical application of backward walking training to improve walking function, balance, and fall-risk in acute stroke: a case series. Top Stroke Rehabil. 2019 Oct;26(7):497-502. doi: 10.1080/10749357.2019.1641011. Epub 2019 Jul 16.