Clinical trial NCT02730377: Efficacy in Controlling Glycaemia With Victoza® (Liraglutide) as add-on to Metformin vs. OADs as add-on to Metformin After up to 104 Weeks of Treatment in Subjects With Type 2 Diabetes
Official title: Efficacy in Controlling Glycaemia With Victoza® (Liraglutide) as add-on to Metformin vs. OADs as add-on to Metformin After up to 104 Weeks of Treatment in Subjects With Type 2 Diabetes Inadequately Controlled With Metformin Monotherapy and Treated in a Primary Care Setting
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Diabetes
Diabetes Mellitus, Type 2
Lead sponsor: Novo Nordisk A/S
Sponsor class: INDUSTRY
First posted: 2016-04-06
Enrollment: 1991
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This trial is conducted globally. The aim of the trial is to investigate efficacy in controlling glycaemia with Victoza® (liraglutide) as add-on to metformin background treatment vs. OADs as add-on to metformin background treatment for 104 weeks of treatment in subjects with type 2 diabetes.


Eligibility criteria: Inclusion Criteria: - Male or female at least 18 years of age at the time of signing informed consent - Subjects diagnosed (clinically) with type 2 diabetes equal to or above 90 days prior to the screening visit - Stable daily dose of metformin as monotherapy equal to or above 1500 mg or maximum tolerated dose within 60 days prior to the screening visit - HbA1c 7.5-9.0% (59-75 mmol/mol) (both inclusive) and measured within the last 90 days prior to the screening visit Exclusion Criteria: - Female who is pregnant, breast-feeding or intends to become pregnant or is of childbearing potential and not using adequate contraceptive methods (adequate contraceptive measures as required by local regulation or practice) - Treatment with any medication for the indication of diabetes other than metformin in a period of 60 days before the screening visit. An exception is short-term treatment (below or equal to 7 days in total) with insulin in connection with intercurrent illness - Receipt of any investigational medicinal product within 30 days before the screening visit - Any disorder, which in the investigator's opinion might jeopardise subject's safety or compliance with the protocol

Primary outcomes:
measure: Time to Inadequate Glycaemic Control
timeFrame: Weeks 26-104
Secondary outcomes:
measure: Time to Premature Treatment Discontinuation (for Any Reason Including Inadequate Glycaemic Control)
timeFrame: Weeks 0-104
measure: Change in HbA1c
timeFrame: Week 0, week 104/premature treatment discontinuation
measure: Participants Who Achieve HbA1c ≤6.5% (Yes/No)
timeFrame: Week 104/Premature treatment discontinuation
measure: Participants Who Achieve HbA1c ≤7.0% Without Weight Gain
timeFrame: Week 104/Premature treatment discontinuation
measure: Participants Who Achieve HbA1c ≤7.0% Without Treatment Emergent Severe Hypoglycaemic Episodes or BG Confirmed Symptomatic Hypoglycaemic Episodes
timeFrame: Week 104/Premature treatment discontinuation
measure: Participants Who Achieve HbA1c ≤7.0% Without Weight Gain and no Treatment Emergent Severe Hypoglycaemic Episodes or Blood Glucose Confirmed Symptomatic Hypoglycaemic Episodes
timeFrame: Week 104/Premature treatment discontinuation
measure: Change in Fasting Plasma Glucose (FPG)
timeFrame: Week 0, week 104/premature treatment discontinuation
measure: Change in Body Weight
timeFrame: Week 0, week 104/premature treatment discontinuation
measure: Change in Body Mass Index (BMI)
timeFrame: Week 0, week 104/premature treatment discontinuation
measure: Change in Blood Pressure (Systolic and Diastolic Blood Pressure)
timeFrame: Week 0, week 104/premature treatment discontinuation
measure: Number of Severe Hypoglycaemic Episodes
timeFrame: Weeks 0-104
measure: Number of Severe or BG Confirmed Symptomatic Hypoglycaemic Episodes
timeFrame: Weeks 0-104
measure: Number of Documented Symptomatic Hypoglycaemic Episodes (ADA)
timeFrame: Weeks 0-104
measure: Number of Serious Adverse Events (SAEs)
timeFrame: Weeks 0-105
measure: Number of AEs Leading to Permanent Discontinuation of Trial Product
timeFrame: Weeks 0-105
measure: Change in Lipids: HDL Cholesterol, LDL-cholesterol, Total Cholesterol, Triglycerides
timeFrame: Week 0, week 104/premature treatment discontinuation
measure: Change in Biochemistry- Alanine Aminotransferase (ALAT), Amylase, Aspartate Aminotransferase (ASAT), Lipase
timeFrame: Week 0, week 104/premature treatment discontinuation
measure: Change in Biochemistry- Creatinine, Total Bilirubin
timeFrame: Week 0, week 104/premature treatment discontinuation
measure: Change in Biochemistry- Estimated Glomerular Filtration Rate (eGFR) Serum
timeFrame: Week 0, week 104/premature treatment discontinuation
measure: Change in Potassium
timeFrame: Week 0, week 104/premature treatment discontinuation
measure: Change in Haemoglobin
timeFrame: Week 0, week 104/premature treatment discontinuation
measure: Change in Pulse
timeFrame: Week 0, week 104/premature treatment discontinuation
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: Novo Nordisk Investigational Site
state: Alabama
city: Haleyville
country: United States
facility: Novo Nordisk Investigational Site
state: Alabama
city: Tuscumbia
country: United States
facility: Novo Nordisk Investigational Site
state: Alabama
city: Fountain Hills
country: United States
facility: Novo Nordisk Investigational Site
state: Arizona
city: Phoenix
country: United States
facility: Novo Nordisk Investigational Site
state: Arizona
city: Phoenix
country: United States
facility: Novo Nordisk Investigational Site
state: Arizona
city: Phoenix
country: United States
facility: Novo Nordisk Investigational Site
state: Arizona
city: Tempe
country: United States
facility: Novo Nordisk Investigational Site
state: Arizona
city: Tucson
country: United States
facility: Novo Nordisk Investigational Site
state: Arizona
city: Harrisburg
country: United States
facility: Novo Nordisk Investigational Site
state: Arkansas
city: Little Rock
country: United States
facility: Novo Nordisk Investigational Site
state: Arkansas
city: North Little Rock
country: United States
facility: Novo Nordisk Investigational Site
state: Arkansas
city: Searcy
country: United States
facility: Novo Nordisk Investigational Site
state: Arkansas
city: Alhambra
country: United States
facility: Novo Nordisk Investigational Site
state: California
city: Buena Park
country: United States
facility: Novo Nordisk Investigational Site
state: California
city: Carlsbad
country: United States
facility: Novo Nordisk Investigational Site
state: California
city: Coronado
country: United States
facility: Novo Nordisk Investigational Site
state: California
city: Costa Mesa
country: United States
facility: Novo Nordisk Investigational Site
state: California
city: Elk Grove
country: United States
facility: Novo Nordisk Investigational Site
state: California
city: Encinitas
country: United States
facility: Novo Nordisk Investigational Site
state: California
city: Huntington Beach
country: United States
facility: Novo Nordisk Investigational Site
state: California
city: La Mirada
country: United States
facility: Novo Nordisk Investigational Site
state: California
city: Lancaster
country: United States
facility: Novo Nordisk Investigational Site
state: California
city: Lomita
country: United States
facility: Novo Nordisk Investigational Site
state: California
city: Montclair
country: United States
facility: Novo Nordisk Investigational Site
state: California
city: Northridge
country: United States
facility: Novo Nordisk Investigational Site
state: California
city: Oxnard
country: United States
facility: Novo Nordisk Investigational Site
state: California
city: Rancho Cucamonga
country: United States
facility: Novo Nordisk Investigational Site
state: California
city: Riverside
country: United States
facility: Novo Nordisk Investigational Site
state: California
city: San Diego
country: United States
facility: Novo Nordisk Investigational Site
state: California
city: San Diego
country: United States
facility: Novo Nordisk Investigational Site
state: California
city: San Ramon
country: United States
facility: Novo Nordisk Investigational Site
state: California
city: Tustin
country: United States
facility: Novo Nordisk Investigational Site
state: California
city: Westminster
country: United States
facility: Novo Nordisk Investigational Site
state: California
city: Centennial
country: United States
facility: Novo Nordisk Investigational Site
state: Colorado
city: Centennial
country: United States
facility: Novo Nordisk Investigational Site
state: Colorado
city: Colorado Springs
country: United States
facility: Novo Nordisk Investigational Site
state: Colorado
city: Golden
country: United States
facility: Novo Nordisk Investigational Site
state: Colorado
city: Monument
country: United States
facility: Novo Nordisk Investigational Site
state: Colorado
city: Chiefland
country: United States
facility: Novo Nordisk Investigational Site
state: Florida
city: Clearwater
country: United States
facility: Novo Nordisk Investigational Site
state: Florida
city: Fort Lauderdale
country: United States
facility: Novo Nordisk Investigational Site
state: Florida
city: Hollywood
country: United States
facility: Novo Nordisk Investigational Site
state: Florida
city: Jacksonville
country: United States
facility: Novo Nordisk Investigational Site
state: Florida
city: Kissimmee
country: United States
facility: Novo Nordisk Investigational Site
state: Florida
city: Miami
country: United States
facility: Novo Nordisk Investigational Site
state: Florida
city: Miami
country: United States
facility: Novo Nordisk Investigational Site
state: Florida
city: Ocala
country: United States
facility: Novo Nordisk Investigational Site
state: Florida
city: Ocoee
country: United States
facility: Novo Nordisk Investigational Site
state: Florida
city: Orlando
country: United States
facility: Novo Nordisk Investigational Site
state: Florida
city: Ormond Beach
country: United States
facility: Novo Nordisk Investigational Site
state: Florida
city: Oviedo
country: United States
facility: Novo Nordisk Investigational Site
state: Florida
city: Palm Harbor
country: United States
facility: Novo Nordisk Investigational Site
state: Florida
city: Pembroke Pines
country: United States
facility: Novo Nordisk Investigational Site
state: Florida
city: Saint Petersburg
country: United States
facility: Novo Nordisk Investigational Site
state: Florida
city: Seminole
country: United States
facility: Novo Nordisk Investigational Site
state: Florida
city: Bainbridge
country: United States
facility: Novo Nordisk Investigational Site
state: Georgia
city: Conyers
country: United States
facility: Novo Nordisk Investigational Site
state: Georgia
city: Perry
country: United States
facility: Novo Nordisk Investigational Site
state: Georgia
city: Statesboro
country: United States
facility: Novo Nordisk Investigational Site
state: Georgia
city: Suwanee
country: United States
facility: Novo Nordisk Investigational Site
state: Georgia
city: Woodstock
country: United States
facility: Novo Nordisk Investigational Site
state: Georgia
city: Meridian
country: United States
facility: Novo Nordisk Investigational Site
state: Idaho
city: Aurora
country: United States
facility: Novo Nordisk Investigational Site
state: Illinois
city: Chicago
country: United States
facility: Novo Nordisk Investigational Site
state: Illinois
city: Gillespie
country: United States
facility: Novo Nordisk Investigational Site
state: Illinois
city: Wauconda
country: United States
facility: Novo Nordisk Investigational Site
state: Illinois
city: Avon
country: United States
facility: Novo Nordisk Investigational Site
state: Indiana
city: Evansville
country: United States
facility: Novo Nordisk Investigational Site
state: Indiana
city: Greenfield
country: United States
facility: Novo Nordisk Investigational Site
state: Indiana
city: Muncie
country: United States
facility: Novo Nordisk Investigational Site
state: Indiana
city: Newton
country: United States
facility: Novo Nordisk Investigational Site
state: Kansas
city: Park City
country: United States
facility: Novo Nordisk Investigational Site
state: Kansas
city: Wichita
country: United States
facility: Novo Nordisk Investigational Site
state: Kansas
city: Lexington
country: United States
facility: Novo Nordisk Investigational Site
state: Kentucky
city: Natchitoches
country: United States
facility: Novo Nordisk Investigational Site
state: Louisiana
city: Shreveport
country: United States
facility: Novo Nordisk Investigational Site
state: Louisiana
city: Sunset
country: United States
facility: Novo Nordisk Investigational Site
state: Louisiana
city: Elkridge
country: United States
facility: Novo Nordisk Investigational Site
state: Maryland
city: Oxon Hill
country: United States
facility: Novo Nordisk Investigational Site
state: Maryland
city: Buckley
country: United States
facility: Novo Nordisk Investigational Site
state: Michigan
city: Rochester
country: United States
facility: Novo Nordisk Investigational Site
state: Michigan
city: Sterling Heights
country: United States
facility: Novo Nordisk Investigational Site
state: Michigan
city: Troy
country: United States
facility: Novo Nordisk Investigational Site
state: Michigan
city: Belzoni
country: United States
facility: Novo Nordisk Investigational Site
state: Mississippi
city: Port Gibson
country: United States
facility: Novo Nordisk Investigational Site
state: Mississippi
city: Butte
country: United States
facility: Novo Nordisk Investigational Site
state: Montana
city: Missoula
country: United States
facility: Novo Nordisk Investigational Site
state: Montana
city: Fremont
country: United States
facility: Novo Nordisk Investigational Site
state: Nebraska
city: Omaha
country: United States
facility: Novo Nordisk Investigational Site
state: Nebraska
city: Las Vegas
country: United States
facility: Novo Nordisk Investigational Site
state: Nevada
city: Albuquerque
country: United States
facility: Novo Nordisk Investigational Site
state: New Mexico
city: Albuquerque
country: United States
facility: Novo Nordisk Investigational Site
state: New Mexico
city: Brooklyn
country: United States
facility: Novo Nordisk Investigational Site
state: New York
city: New Windsor
country: United States
facility: Novo Nordisk Investigational Site
state: New York
city: North Massapequa
country: United States
facility: Novo Nordisk Investigational Site
state: New York
city: Westfield
country: United States
facility: Novo Nordisk Investigational Site
state: New York
city: Asheboro
country: United States
facility: Novo Nordisk Investigational Site
state: North Carolina
city: Burlington
country: United States
facility: Novo Nordisk Investigational Site
state: North Carolina
city: Charlotte
country: United States
facility: Novo Nordisk Investigational Site
state: North Carolina
city: Charlotte
country: United States
facility: Novo Nordisk Investigational Site
state: North Carolina
city: Charlotte
country: United States
facility: Novo Nordisk Investigational Site
state: North Carolina
city: Elizabeth City
country: United States
facility: Novo Nordisk Investigational Site
state: North Carolina
city: Garner
country: United States
facility: Novo Nordisk Investigational Site
state: North Carolina
city: Mooresville
country: United States
facility: Novo Nordisk Investigational Site
state: North Carolina
city: Morganton
country: United States
facility: Novo Nordisk Investigational Site
state: North Carolina
city: Whiteville
country: United States
facility: Novo Nordisk Investigational Site
state: North Carolina
city: Fargo
country: United States
facility: Novo Nordisk Investigational Site
state: North Dakota
city: Columbus
country: United States
facility: Novo Nordisk Investigational Site
state: Ohio
city: Dayton
country: United States
facility: Novo Nordisk Investigational Site
state: Ohio
city: Franklin
country: United States
facility: Novo Nordisk Investigational Site
state: Ohio
city: Mason
country: United States
facility: Novo Nordisk Investigational Site
state: Ohio
city: Toledo
country: United States
facility: Novo Nordisk Investigational Site
state: Ohio
city: Wadsworth
country: United States
facility: Novo Nordisk Investigational Site
state: Ohio
city: Edmond
country: United States
facility: Novo Nordisk Investigational Site
state: Oklahoma
city: Oklahoma City
country: United States
facility: Novo Nordisk Investigational Site
state: Oklahoma
city: Oklahoma City
country: United States
facility: Novo Nordisk Investigational Site
state: Oklahoma
city: Beaver
country: United States
facility: Novo Nordisk Investigational Site
state: Pennsylvania
city: Fleetwood
country: United States
facility: Novo Nordisk Investigational Site
state: Pennsylvania
city: Harleysville
country: United States
facility: Novo Nordisk Investigational Site
state: Pennsylvania
city: Jersey Shore
country: United States
facility: Novo Nordisk Investigational Site
state: Pennsylvania
city: Lansdale
country: United States
facility: Novo Nordisk Investigational Site
state: Pennsylvania
city: Levittown
country: United States
facility: Novo Nordisk Investigational Site
state: Pennsylvania
city: Levittown
country: United States
facility: Novo Nordisk Investigational Site
state: Pennsylvania
city: McMurray
country: United States
facility: Novo Nordisk Investigational Site
state: Pennsylvania
city: Philadelphia
country: United States
facility: Novo Nordisk Investigational Site
state: Pennsylvania
city: Pittsburgh
country: United States
facility: Novo Nordisk Investigational Site
state: Pennsylvania
city: Pittsburgh
country: United States
facility: Novo Nordisk Investigational Site
state: Pennsylvania
city: Smithfield
country: United States
facility: Novo Nordisk Investigational Site
state: Pennsylvania
city: Uniontown
country: United States
facility: Novo Nordisk Investigational Site
state: Pennsylvania
city: Providence
country: United States
facility: Novo Nordisk Investigational Site
state: Rhode Island
city: Anderson
country: United States
facility: Novo Nordisk Investigational Site
state: South Carolina
city: Columbia
country: United States
facility: Novo Nordisk Investigational Site
state: South Carolina
city: Greer
country: United States
facility: Novo Nordisk Investigational Site
state: South Carolina
city: Indian Land
country: United States
facility: Novo Nordisk Investigational Site
state: South Carolina
city: Pelzer
country: United States
facility: Novo Nordisk Investigational Site
state: South Carolina
city: Simpsonville
country: United States
facility: Novo Nordisk Investigational Site
state: South Carolina
city: Rapid City
country: United States
facility: Novo Nordisk Investigational Site
state: South Dakota
city: Athens
country: United States
facility: Novo Nordisk Investigational Site
state: Tennessee
city: Chattanooga
country: United States
facility: Novo Nordisk Investigational Site
state: Tennessee
city: Humboldt
country: United States
facility: Novo Nordisk Investigational Site
state: Tennessee
city: Kingsport
country: United States
facility: Novo Nordisk Investigational Site
state: Tennessee
city: Tullahoma
country: United States
facility: Novo Nordisk Investigational Site
state: Tennessee
city: Arlington
country: United States
facility: Novo Nordisk Investigational Site
state: Texas
city: Arlington
country: United States
facility: Novo Nordisk Investigational Site
state: Texas
city: Carrollton
country: United States
facility: Novo Nordisk Investigational Site
state: Texas
city: Corpus Christi
country: United States
facility: Novo Nordisk Investigational Site
state: Texas
city: Corpus Christi
country: United States
facility: Novo Nordisk Investigational Site
state: Texas
city: Dallas
country: United States
facility: Novo Nordisk Investigational Site
state: Texas
city: Fort Worth
country: United States
facility: Novo Nordisk Investigational Site
state: Texas
city: Georgetown
country: United States
facility: Novo Nordisk Investigational Site
state: Texas
city: Gonzales
country: United States
facility: Novo Nordisk Investigational Site
state: Texas
city: Houston
country: United States
facility: Novo Nordisk Investigational Site
state: Texas
city: Houston
country: United States
facility: Novo Nordisk Investigational Site
state: Texas
city: Houston
country: United States
facility: Novo Nordisk Investigational Site
state: Texas
city: Houston
country: United States
facility: Novo Nordisk Investigational Site
state: Texas
city: Houston
country: United States
facility: Novo Nordisk Investigational Site
state: Texas
city: Houston
country: United States
facility: Novo Nordisk Investigational Site
state: Texas
city: Irving
country: United States
facility: Novo Nordisk Investigational Site
state: Texas
city: Kerrville
country: United States
facility: Novo Nordisk Investigational Site
state: Texas
city: Killeen
country: United States
facility: Novo Nordisk Investigational Site
state: Texas
city: Longview
country: United States
facility: Novo Nordisk Investigational Site
state: Texas
city: Missouri City
country: United States
facility: Novo Nordisk Investigational Site
state: Texas
city: New Braunfels
country: United States
facility: Novo Nordisk Investigational Site
state: Texas
city: San Antonio
country: United States
facility: Novo Nordisk Investigational Site
state: Texas
city: Splendora
country: United States
facility: Novo Nordisk Investigational Site
state: Texas
city: Sugar Land
country: United States
facility: Novo Nordisk Investigational Site
state: Texas
city: Sugar Land
country: United States
facility: Novo Nordisk Investigational Site
state: Texas
city: Waco
country: United States
facility: Novo Nordisk Investigational Site
state: Texas
city: Bountiful
country: United States
facility: Novo Nordisk Investigational Site
state: Utah
city: Saint George
country: United States
facility: Novo Nordisk Investigational Site
state: Utah
city: Danville
country: United States
facility: Novo Nordisk Investigational Site
state: Virginia
city: Gloucester Courthouse
country: United States
facility: Novo Nordisk Investigational Site
state: Virginia
city: Norfolk
country: United States
facility: Novo Nordisk Investigational Site
state: Virginia
city: Richmond
country: United States
facility: Novo Nordisk Investigational Site
state: Virginia
city: Virginia Beach
country: United States
facility: Novo Nordisk Investigational Site
state: Virginia
city: Bellevue
country: United States
facility: Novo Nordisk Investigational Site
state: Washington
city: Spokane
country: United States
facility: Novo Nordisk Investigational Site
state: Washington
city: Walla Walla
country: United States
facility: Novo Nordisk Investigational Site
state: Washington
city: Surrey
country: Canada
facility: Novo Nordisk Investigational Site
state: British Columbia
city: Mount Pearl
country: Canada
facility: Novo Nordisk Investigational Site
state: Newfoundland and Labrador
city: Truro
country: Canada
facility: Novo Nordisk Investigational Site
state: Nova Scotia
city: Hamilton
country: Canada
facility: Novo Nordisk Investigational Site
state: Ontario
city: Sarnia
country: Canada
facility: Novo Nordisk Investigational Site
state: Ontario
city: Strathroy
country: Canada
facility: Novo Nordisk Investigational Site
state: Ontario
city: Toronto
country: Canada
facility: Novo Nordisk Investigational Site
state: Ontario
city: Toronto
country: Canada
facility: Novo Nordisk Investigational Site
state: Ontario
city: Waterloo
country: Canada
facility: Novo Nordisk Investigational Site
state: Ontario
city: Montreal
country: Canada
facility: Novo Nordisk Investigational Site
state: Quebec
city: St-Marc-des-Carrières
country: Canada
facility: Novo Nordisk Investigational Site
state: Quebec
city: Quebec
country: Canada
facility: Novo Nordisk Investigational Site
city: Bogota
country: Colombia
facility: Novo Nordisk Investigational Site
city: Bogota
country: Colombia
facility: Novo Nordisk Investigational Site
city: Medellin
country: Colombia
facility: Novo Nordisk Investigational Site
city: Bangalore
country: India
facility: Novo Nordisk Investigational Site
state: Karnataka
city: Bangalore
country: India
facility: Novo Nordisk Investigational Site
state: Karnataka
city: Bangalore
country: India
facility: Novo Nordisk Investigational Site
state: Karnataka
city: Mysore
country: India
facility: Novo Nordisk Investigational Site
state: Karnataka
city: Indore
country: India
facility: Novo Nordisk Investigational Site
state: Madhya Pradesh
city: Nagpur
country: India
facility: Novo Nordisk Investigational Site
state: Maharashtra
city: Pune
country: India
facility: Novo Nordisk Investigational Site
state: Maharashtra
city: Pune
country: India
facility: Novo Nordisk Investigational Site
state: Maharashtra
city: Pune
country: India
facility: Novo Nordisk Investigational Site
state: Maharashtra
city: Hyderabad
country: India
facility: Novo Nordisk Investigational Site
state: Telengana
city: Lucknow
country: India
facility: Novo Nordisk Investigational Site
state: Uttar Pradesh
city: Noida
country: India
facility: Novo Nordisk Investigational Site
state: Uttar Pradesh
city: Kolkata
country: India
facility: Novo Nordisk Investigational Site
state: West Bengal
city: Kolkata
country: India
facility: Novo Nordisk Investigational Site
state: West Bengal
city: Hubli
country: India
facility: Novo Nordisk Investigational Site
city: Ludhiana
country: India
facility: Novo Nordisk Investigational Site
city: Riga
country: Latvia
facility: Novo Nordisk Investigational Site
city: Riga
country: Latvia
facility: Novo Nordisk Investigational Site
city: Tukums
country: Latvia
facility: Novo Nordisk Investigational Site
city: Achrafieh
country: Lebanon
facility: Novo Nordisk Investigational Site
city: Beirut
country: Lebanon
facility: Novo Nordisk Investigational Site
city: Hazmieh
country: Lebanon
facility: Novo Nordisk Investigational Site
city: Jbeil
country: Lebanon
facility: Novo Nordisk Investigational Site
city: Toa Baja
country: Puerto Rico
facility: Novo Nordisk Investigational Site
city: Trujillo Alto
country: Puerto Rico
facility: Novo Nordisk Investigational Site
city: Dzerzhinskiy
country: Russian Federation
facility: Novo Nordisk Investigational Site
city: Moscow
country: Russian Federation
facility: Novo Nordisk Investigational Site
city: Moscow
country: Russian Federation
facility: Novo Nordisk Investigational Site
city: Moscow
country: Russian Federation
facility: Novo Nordisk Investigational Site
city: Saint-Petersburg
country: Russian Federation
facility: Novo Nordisk Investigational Site
city: Belgrade
country: Serbia
facility: Novo Nordisk Investigational Site
city: Kragujevac
country: Serbia
facility: Novo Nordisk Investigational Site
city: Nis
country: Serbia
facility: Novo Nordisk Investigational Site
city: Novi Sad
country: Serbia
facility: Novo Nordisk Investigational Site
city: Adapazari
country: Turkey
facility: Novo Nordisk Investigational Site
city: Istanbul
country: Turkey
facility: Novo Nordisk Investigational Site
city: Istanbul
country: Turkey
facility: Novo Nordisk Investigational Site
city: Istanbul
country: Turkey
facility: Novo Nordisk Investigational Site
Study officials:
References:
citation: Unger J, Allison DC, Carlton M, Lakkole K, Lowe D, Murphy G, Panda JK, Sargin M, Kaltoft M, Treppendahl MB, Zoghbi M; LIRA-PRIME global panel. Trial design and baseline data for LIRA-PRIME: A randomized trial investigating the efficacy of liraglutide in controlling glycaemia in type 2 diabetes in a primary care setting. Diabetes Obes Metab. 2019 Jul;21(7):1543-1550. doi: 10.1111/dom.13682. Epub 2019 Mar 26.