Clinical trial NCT05862987: The Effect of Hydrogen Rich Water Intake on Acute Body Response and Following Recovery After 5 km Run in Untrained Men
Official title: The Effect of Hydrogen Rich Water Intake on Acute Body Response and Following Recovery After Single 5 km Run in Endurance-untrained Men. Randomized, Double Blinded, Placebo Controlled, Cross-over Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Athletic Performance
Muscle Fatigue
Oxidative Stress
Lead sponsor: Palacky University
Sponsor class: OTHER
First posted: 2023-05-17
Enrollment: 16
Sex: MALE
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: PREVENTION

Brief summary: The aim of this randomized, double blinded, placebo controlled cross-over study is to evaluate the effect of hydrogen rich water intake on running performance, physiological and biochemical variables during endurance exercise and following recovery in endurance-untrained men.

Detailed description: This study involves 16 endurance-untrained men aged 18-30 years. All participants drink hydrogen rich water (HRW) or placebo during the two days before the experiment (total volume 2100 ml) and during the testing day (total volume 1680 ml). All participants undergo one laboratory session (entry diagnostic) and two experimental sessions in the field with a washout period of 7 days. In the two experimental sessions, participants receive HRW or placebo in a randomized order. Each experimental session consisted of a pre-exercise phase, an exercise phase (5 km run), and a 24 h passive recovery phase. The following variables are assessed: running times (5 km distance and 200 m laps), heart rate, rating of perceived exertion, blood lactate, reactive strength index, subjective perceived muscle soreness, protein carbonyl content, malondialdehyde content, heart rate variability. Statistical analysis is based on analysis of variance for repeated measures with the factors water (HRW and placebo), time, and interaction. Fisher´s post hoc tests is used for pairwise comparison. The significance level is set at 0.05.

Eligibility criteria: Inclusion Criteria:

* No experience with endurance training.
* Good health condition.
* Signed informed content.

Exclusion Criteria:

* Acute health problems.
* Not following instructions (free of any supplements three weeks before experiment, free of any medicaments, no caffeine at least 24 hours before experiment).

Primary outcomes:
measure: Run time
timeFrame: Change between values before and after 7 days of crossover.
Secondary outcomes:
measure: Heart rate during running
timeFrame: Change between values before and after 7 days of crossover.
measure: Rating of perceived exertion
timeFrame: Change between values before and after 7 days of crossover.
measure: Blood lactate
timeFrame: Change between values before and after 7 days of crossover.
measure: Reactive strength index
timeFrame: Change between values before and after 7 days of crossover.
measure: Subjective perceived muscle soreness
timeFrame: Change between values before and after 7 days of crossover.
measure: Protein carbonyls
timeFrame: Change between values before and after 7 days of crossover.
measure: Malondialdehydes
timeFrame: Change between values before and after 7 days of crossover.
measure: Heart rate variability - heart rate
timeFrame: Change between values before and after 7 days of crossover.
measure: Heart rate variability - RMSSD
timeFrame: Change between values before and after 7 days of crossover.
measure: Heart rate variability - SDNN
timeFrame: Change between values before and after 7 days of crossover.
measure: Heart rate variability - LF/HF
timeFrame: Change between values before and after 7 days of crossover.
Other outcomes:
Locations:
city: Olomouc
country: Czechia
facility: Palacky University, Faculty of Physical Culture
Study officials:
affiliation: Palacky University
name: Michal Valenta, Mgr
role: PRINCIPAL_INVESTIGATOR
References: