louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06708728: Study of Acquired Hemolytic Anemia in Adult Hospitalized Patients
Official title: Study of the Etiology, Clinical Features and Short Term Outcome of Acquired Hemolytic Anemia in Hospitalized Adult Patients with Non-Neoplastic Disease
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Hemolytic Anemia
Lead sponsor: Sohag University
Sponsor class: OTHER
First posted: 2024-11-27
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients admitted in Internal Medicine department and Intermediate care unit at sohag university hospital

Brief summary: the goal of the study is to identify the most common etiological factors and analyze the clinical presentations and laboratory findings in hospitalized patients with acquired hemolytic anemia associated with non-neoplastic diseases.

And to evaluate short-term outcomes, including morbidity and mortality rates, and to determine correlations between specific etiological factors and patient outcomes in these cases.


Eligibility criteria: Inclusion Criteria:

* Adults aged 18 years and older.
* Patients diagnosed with acquired hemolytic anemia.
* Patients must be hospitalized in the Internal Medicine department at the time of diagnosis of acquired hemolytic anemia during the study period
* Patients (or their legal representatives) must provide informed

Exclusion Criteria:

* Patients with underlying neoplastic diseases.
* Patients with hereditary hemolytic anemia.
* Patients or their representatives who do not consent to participate in the study.

Primary outcomes:
measure: intensive care unit admission of the patients due to progression of the disease complications.
timeFrame: through study completion, an average of 6 months
Secondary outcomes:
measure: mortality within duration of hospital admission
timeFrame: through study completion, an average of 6 months
Other outcomes:
Locations:
city: Sohag
country: Egypt
facility: Faculty of Medicine Sohag University
Study officials:
References:
Clinical trial NCT04243928: Role of Kinesiotape Over Dorsi Flexors Muscles on Balance in Children With Spastic Diplegia
Official title: Role of Kinesiotape Over Dorsi Flexors Muscles on Balance in Children With Spastic Diplegia (Using Biodex Balance System)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cerebral Palsy
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2020-01-28
Enrollment: 30
Sex: ALL
Minimum age (years): 4
Maximum age (years): 10
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: children rranged from 4 years uo to 10 years with Spastic diplegia
Primary purpose: TREATMENT

Brief summary: To detect the effect of kinesio -tape on balance in children with spastic diplegia.

Detailed description: The use of Kinesio Taping might influence the cutaneous receptors of the sensory motor system, resulting in the improvement of voluntary control and coordination in a physiotherapy program for children with CP. (Yasukawa et al., 2006).

The study will be conducted To investigate the effect of kinesiotape applied on dorsi fexors muscles on improving balance in spastic diplegic children .

Eligibility criteria: Inclusion Criteria:

* • Thirty children with spastic diplegia of both genders participated in this study.

  * Theywere selected from the out-patient clinic, faculty of physical therapy, Cairo University.
  * Children height not less than 1 meter to be able to see the screen of the biodex balance system.
  * Their agehad ranged from 4 to 8 years.
  * All patients have mild spasticity according to modified Aschwar scale grade 1 \&1+ (Alhusaini, 2010) presented in (Appendix I).
  * All patients wereable to stand alone GMFM presented in (Appendix II).
  * They could understand and follow instructions.
  * All Children used Ankle Foot Orthosis.

Exclusion Criteria:

* • Children with visual or auditory problems.

  * Children with positive sensitivity to kinesiotape.
  * Children with irrivisable muscle contracture at the calf muscles.

Primary outcomes:
measure: effect of K-Tape on balance
timeFrame: three months
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Cairo Univeristy
Study officials:
affiliation: Cairo University
name: I
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02166528: The Study of Genes Localization for Female Pelvic Floor Dysfunction
Official title: The Study of Susceptibility Genes Localization for Female Pelvic Floor Dysfunction
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Female Pelvic Floor Dysfunction
Keywords: female pelvic floor dysfunction
pelvic organ prolaps
urinary incontinence
massively parallel sequencing
Lead sponsor: Third Military Medical University
Sponsor class: OTHER
Collaborators: name: Shenzhen Huada Genomics Co., Ltd.
First posted: 2014-06-18
Enrollment: 200
Sex: FEMALE
Minimum age (years): 30
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The experiment group are patients with PFD. While the control group are volunteer patients without PFD on the basis of informed consent.

Brief summary: Female pelvic floor dysfunction (FPD) is due to defects in the pelvic support structures, degradation, damage or dysfunction. The main problem of which is pelvic organ prolapse(POP), urinary incontinence(UI) and genital tract injury. Although it does not pose a serious threat to life, but affect the patient's quality of life seriously in the physical, psychological, social behavior and other aspects. With the growing aging population, the incidence rate has gradually increased, and increasing demands for people's quality of life simultaneously, more and more attention was raised to PFD as common chronic diseases.

In recent years, the basic research, epidemiology, prevention, diagnosis and treatment of PFD have made great progress, especially in developing gynecological urology theory and reconstructive pelvic surgery. But overall the basic research of PFD is lagging behind, especially susceptibility gene localization and functional studies did not get enough attention.


Eligibility criteria: Inclusion Criteria:

1. female aging from 30 to 70-year old;
2. preoperative diagnosis of gynecologic malignancies;
3. have the ability to comply with Research programs;
4. voluntarily participate in the study and signed an informed consent form

Exclusion Criteria:

1. patients with severe cardiovascular diseases, kidney, liver and other vital organs diseases, bone marrow disease and mental illness;
2. patients suffering from autoimmune diseases;
3. patients with acute infectious disease or infection early phase of infection;
4. patients with urinary tract infection;
5. patients with infection or erosion of ano-genital skin;
6. for any other reason, the researchers considered unsuitable for inclusion.

Primary outcomes:
measure: susceptibility genes localization
timeFrame: 4 years
Secondary outcomes:
Other outcomes:
Locations:
city: Chongqing
country: China
facility: Department of Obstetrics and Gynaecology, Southwest Hospital, Third Military
state: Chongqing
Study officials:
References:
Clinical trial NCT02686528: Postoperative Hip Precautions After Total Hip Arthroplasty Via the Posterior Approach: A Prospective Randomized Trial
Official title: Are Postoperative Hip Precautions Necessary After a Total Hip Arthroplasty Via the Posterior Approach: A Prospective Randomized Trial
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Osteoarthritis
Degenerative Joint Disease
Keywords: total hip arthroplasty
hip precautions
posterior approach
Lead sponsor: Rush University Medical Center
Sponsor class: OTHER
First posted: 2016-02-19
Enrollment: 1000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine if hip precautions, which are instructions that limit functional use of a hip replacement after surgery, affect the rate of dislocation in the first six weeks after primary total hip replacement surgery. The impact of hip precautions on a patient's return to activities of daily living and overall patient satisfaction will also be investigated. The overall cost effectiveness of hip precautions will be determined.

Detailed description: This study examines the necessity of postoperative hip precautions in patients after primary total hip arthroplasty via the posterior approach. Precautions are instructions that limit the functional use of the hip and are given for the first six weeks after surgery, with the goal of preventing an instability event resulting in dislocation. The hip precautions that will be investigated in this study are: no hip flexion past 90º, no crossing the legs, and no twisting at the waist.

Eligibility criteria: Inclusion Criteria:

* Patients undergoing a primary total hip arthroplasty via the posterior approach by participating attending surgeons at this institution
* Index diagnosis of noninflammatory arthritis
* Patients must be able to understand and comply with study procedures

Exclusion Criteria:

* Allergy or intolerance to the study materials
* History of previous surgeries on the affected joint other than arthroscopy; i.e. revision THA or open surgeries

Primary outcomes:
measure: Dislocation
timeFrame: 6 weeks after surgery
Secondary outcomes:
measure: Activities of Daily Living
timeFrame: 1 year after surgery
Other outcomes:
measure: Use of Assistive Devices After Surgery
timeFrame: 6 months after surgery
Locations:
city: Chicago
country: United States
facility: Rush University Medical Center
state: Illinois
Study officials:
affiliation: Orthopedics Surgeon
name: Omar Behery, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01404728: Longitudinal Evaluation Study of Vaginal Stenosis With and Without Pelvic Radiation Therapy
Official title: Prospective Longitudinal Evaluation of Vaginal Stenosis and Sexual Function in Women With Pelvic Malignancies Treated With and Without Pelvic Radiation Therapy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Malignancies
Stenosis of Vagina
Keywords: Vaginal length
Sexual dysfunction
Lead sponsor: University of Colorado, Denver
Sponsor class: OTHER
First posted: 2011-07-28
Enrollment: 8
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Women being treated for pelvic malignancies in the primary care clinic.

Brief summary: This study evaluates the effects of treatment with a vaginal dilator to reduce vaginal stenosis in women receiving pelvic radiation therapy for pelvic malignancies.

Detailed description: Vaginal stenosis can occur as a result of treatment for pelvic malignancies. Women receiving pelvic radiation therapy using a vaginal dilator 5-7 times per week will have less vaginal stenosis than women using a vaginal dilator fewer times or not at all.

Eligibility criteria: Inclusion Criteria:

* Pre and post menopausal women undergoing definitive (not palliative) treatments for a pelvic malignancy, including rectal, endometrial, cervical, or anal canal carcinoma.
* Treatments include radiation therapy, chemotherapy, surgery, or a combination of therapies.
* May have early-stage or locally advanced (node positive) disease.
* Male partners of the female subjects are also consented for this study.

Exclusion Criteria:

* Subject may not have evidence of metastatic disease.
* Prior pelvic radiation therapy
* Prior hysterectomy (not for current diagnosis)
* Diagnosis of prior malignancy, except non-melanoma skin cancer.

Primary outcomes:
measure: Observation of a change in vaginal length as measured with a vaginal sound (modified vaginal dilator)
timeFrame: Up to 24 Months
measure: Observation of change in sexual function/satisfaction as measured by the Sexual Adjustment Questionnaire (SAQ)
timeFrame: Up to 24 Months
Secondary outcomes:
Other outcomes:
Locations:
city: Aurora
country: United States
facility: University of Colorado Hospital
state: Colorado
Study officials:
affiliation: University of Colorado, Denver
name: Christine Fisher, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01950728: Electrical Currents on Hypoalgesia
Official title: Hypoalgesic Effect of Low Frequency and Burst Modulated Alternating Currents on Healthy Individuals.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Keywords: volunteers
18 to 65 years
Males and Females
Lead sponsor: Paulista University
Sponsor class: OTHER
First posted: 2013-09-25
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The objective of this study is to compare the hypoalgesic effects of TENS, Interferential current and Aussie current in pressure pain threshold and sensory discomfort in healthy subjects.


Eligibility criteria: Inclusion Criteria:

* health adults

Exclusion Criteria:

* injury to nerves of the upper limbs, pain, pregnancy, chronic diseases, cardiac pacemaker, epilepsy, allergy to the electrode used, use of pain medication, skin lesions or lack of sensitivity in the areas of electrode placement

Primary outcomes:
measure: Pressure Pain Threshold
timeFrame: Baseline, 15 minutes after the beginning of electrical stimulation, 30 minutes after the beginning of electrical stimulation, and 20 minutes after electrical stimulation.
Secondary outcomes:
measure: Sensory Discomfort
timeFrame: 15 and 30 minutes after the beginning of electrical stimulation.
Other outcomes:
Locations:
city: São Paulo
country: Brazil
facility: CPA Pompéia UNIP
Study officials:
References:
citation: Rampazo da Silva EP, da Silva VR, Bernardes AS, Matuzawa FM, Liebano RE. Study protocol of hypoalgesic effects of low frequency and burst-modulated alternating currents on healthy individuals. Pain Manag. 2018 Mar;8(2):71-77. doi: 10.2217/pmt-2017-0058. Epub 2018 Feb 16.
Clinical trial NCT01064128: Study of Different Pain Scores in Single-Port Access (SPA) Laparoscopic Hysterectomy Versus Conventional Laparoscopic Hysterectomy
Official title: Randomized Controlled Study of Different Pain Scores in Single-Port Access (SPA) Laparoscopic Hysterectomy Versus Conventional Laparoscopic Hysterectomy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Uterine Myoma
Uterine Adenomyosis
Keywords: Single-port
Laparoscopy
Hysterectomy
Pain
Cosmesis
Analgesics
Lead sponsor: Samsung Medical Center
Sponsor class: OTHER
First posted: 2010-02-08
Enrollment: 40
Sex: FEMALE
Minimum age (years): 30
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Purpose:

The attempt to further reduce the operative trauma in laparoscopic hysterectomy led in new technique such as Single-Port Access (SPA) laparoscopic surgery. This new technique is considered as painless procedure and better cosmetic effect but there are not any publications to study a possible different pain score and cosmetic effect in new techniques versus conventional laparoscopic hysterectomy. In this randomized controlled study the researchers have investigated the pain scores and cosmetic satisfaction by modified body image scale and cosmetic scar scale.


Eligibility criteria: Inclusion Criteria:

* Age 30-60, female
* Symptomatic (Dysmenorrhea, Palpable mass, Pelvic pain or discomfort, Urinary symptom, Increasing size, Menorrhagia) myomas or adenomyosis
* Suspected uterine myoma and/or adenomyosis on transvaginal ultrasonography (USG)
* At least a 6-month thorough follow-up record available
* Informed consent

Exclusion Criteria:

* Endometrial hyperplasia without myoma or adenomyosis
* Body Mass Index more than 30
* Huge uterus defined by longitudinal uterine diameter larger than 10cm and anteroposterior diameter larger than 8cm in USG

Primary outcomes:
measure: Pain score measured by visual analog scale
timeFrame: postoperative 24 hours
Secondary outcomes:
measure: Modified body image scale and cosmetic scar scale
timeFrame: postoperative 6 months
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
Study officials:
References:
Clinical trial NCT03814928: Caregivers' eCourse for Recovery After Hip Fracture
Official title: Recovery After Hip Fracture: A Novel Online Intervention for Caregivers
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Hip Fractures
Family
Keywords: education
caregivers
eCourse
feasibility
Lead sponsor: University of British Columbia
Sponsor class: OTHER
First posted: 2019-01-24
Enrollment: 230
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: feasibility study with the general public, older adults, health providers, and family caregivers.
Primary purpose: OTHER

Brief summary: In this two part study, we will seek 1. general feedback on the feasibility of an online education and skill development program for family/caregivers of older adults recovering from a surgically repaired low-trauma hip fracture. We will also 2. test its feasibility and acceptability with family caregivers.

Detailed description: This is a cross-sectional mixed methods study to obtain feedback from health providers and family caregivers on eCourse for the post-hip fracture period. For participants who access the course via the PI's website, participants will only be asked to provide feedback on the content, layout, and delivery of the eCourse.

Eligibility criteria: Inclusion Criteria:

* Family/caregivers of older adults with hip fracture, health providers, older adults, and/or general public

Exclusion Criteria:

* Adults less than 19 years of age

Primary outcomes:
measure: eCourse Acceptibility
timeFrame: Day 1
measure: eCourse Feasibility
timeFrame: Day 1
measure: eCourse Satisfaction
timeFrame: Day 1
measure: eCourse Usefulness
timeFrame: Day 1
measure: Modified Computer Self-Efficacy Scale
timeFrame: Day 1
measure: Unified Theory of Acceptance and Use of Technology 2
timeFrame: Day 1
measure: Caregivers' eCourse semi-structured interviews
timeFrame: Day 1
measure: Feedback on eCourse for participants who enrol via the PI's website: PEMAT
timeFrame: Day 1
Secondary outcomes:
measure: Caregiver Strain Index
timeFrame: Day 1
measure: EQ5D-5L (health-related quality of life)
timeFrame: Day 1
measure: ICECAP-O (general quality of life)
timeFrame: Day 1
Other outcomes:
Locations:
city: Vancouver
country: Canada
facility: UBC
Study officials:
References:
Clinical trial NCT00893828: Monitoring Pulmonary Artery Pressure by Implantable Device Responding to Ultrasonic Signal (PAPIRUS III)
Official title: Monitoring Pulmonary Artery Pressure by Implanted Device Responding to Ultrasonic Signal
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Heart Failure
Lead sponsor: Boston Scientific Corporation
Sponsor class: INDUSTRY
First posted: 2009-05-06
Enrollment: 18
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients previously implanted with a RemonCHF device

Brief summary: The PAPIRUS III study will continue to follow patients initially enrolled in PAPIRUS II. Pressure readings from the investigational device will continue to be collected and will be correlated to physiological changes during activities of daily living and protocol defined tests.

Detailed description: This is a small clinical trial to determine the feasibility of a device \& to test prototype device, where the primary outcome measure relates to feasibility and not to health outcomes.

Eligibility criteria: Inclusion Criteria:

* Patient has been enrolled in the PAPIRUS II Study and has a RemonCHF pressure sensor implanted
* Patient is willing and able to provide informed consent, participate in the Safety Follow-up Program and/or in the required tests associated with the clinical investigation (Core Study Program) at an approved clinical investigational center and at the intervals defined by the Clinical Investigational Plan.

Exclusion Criteria:

* Patient enrolled in PAPIRUS II but not implanted with a RemonCHF Pressure Sensor
* Patients who are currently enrolled in another investigational study or registry that would directly interfere with the current study (with the exception of the PAPIRUS II Study). Each instance would be brought to the sponsor to determine eligibility.
* Age \< 18 years
* Women of childbearing potential who are, or might be, pregnant at the time of the study

Primary outcomes:
measure: Continue detailed data collection of pressure readings from patients implanted with a RemonCHF device.
timeFrame: 24 months
Secondary outcomes:
Other outcomes:
Locations:
city: Cologne
country: Germany
facility: University of Cologne
Study officials:
affiliation: University of Cologne
name: Uta C Hoppe, Prof. Dr.
role: PRINCIPAL_INVESTIGATOR
References: