Clinical trial NCT04513054: Is There a Genetic Predisposition for Acute Stress-induced (Takotsubo) Cardiomyopathy
Official title: Is There a Genetic Predisposition for Acute Stress-induced (Takotsubo) Cardiomyopathy: The GENETIC Study
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Takotsubo Cardiomyopathy
Lead sponsor: University of Aberdeen
Sponsor class: OTHER
First posted: 2020-08-14
Enrollment: 700
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Single group observational study.
Primary purpose: OTHER

Brief summary: Acute stress-induced (takotsubo) cardiomyopathy or broken heart syndrome presents like a heart attack, classically is triggered by intense emotional or physical stress and can have serious health consequences. In the current study the investigators wish to establish whether there is a genetic predisposition making certain people more susceptible to this condition. This could also have implications for their families.

Detailed description: Acute stress-induced (takotsubo) cardiomyopathy presents like a myocardial infarct, is triggered by intense emotional or physical stress, and can have catastrophic and potentially fatal consequences. Despite data linking takotsubo cardiomyopathy with conditions that have a recognized genetic predisposition (such as mental health and neurological problems), a systematic and comprehensive characterisation of the genetic-epidemiologic factors in takotsubo is lacking. The researchers propose to further investigate this disorder by collecting blood from probands and characterising the genotype of patients with takotsubo cardiomyopathy in a large scale, nationwide genome wide association study. The investigators will also archive DNA for identification of future candidate genetic variants. Ultimately, understanding the underlying predisposition of this poorly understood neuro-psycho-cardiac disorder is essential if we are to move this field forward.

Eligibility criteria: Inclusion Criteria:

* All patients who have been diagnosed with Takotsubo cardiomyopathy in Scotland between 2010 to date.
* Familial cases elsewhere in the world who would be willing to participate.

Exclusion Criteria:

* Unwillingness to participate

Primary outcomes:
measure: Genome Wide Association Study
timeFrame: At baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Aberdeen
country: United Kingdom
facility: Cardiovascular Research Facility
state: Aberdeenshire
Study officials:
affiliation: University of Aberdeen
name: Dana K Dawson, MD, MPhil
role: PRINCIPAL_INVESTIGATOR
References:
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