Clinical trial NCT03347305: Measurement of the Energy Metabolism of Peritoneal Dialysis Patients
Official title: Study in Calorimetric Room of the Energy Metabolism of Renal Impairment Patients Treated With Automated Peritoneal Dialysis
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Renal Failure
Keywords: Energy expenditure
Peritoneal dialysis
Lead sponsor: University Hospital, Clermont-Ferrand
Sponsor class: OTHER
Collaborators: name: Pôle Santé République
name: Service de Néphrologie et Hémodialyse
name: Jacques Lacarin Hospital Center
First posted: 2017-11-20
Enrollment: 24
Sex: MALE
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: The daily energy expenditure of patients treated with peritoneal dialysis could be increased compared to the general population and promote the development of a state of undernutrition. Conversely, the absorption of glucose by transperitoneal route could contribute to the occurrence of a metabolic syndrome.

The main objective is to compare DE and its variations according to the conditions (rest, sleep, meals, physical activity) in patients treated with automated DP compared to controls, in a calorimetric chamber.

Detailed description: The daily energy expenditure of patients treated with peritoneal dialysis could be increased compared to the general population and promote the development of a state of undernutrition. Conversely, the absorption of glucose by transperitoneal route could contribute to the occurrence of a metabolic syndrome.

The main objective is to compare DE and its variations according to the conditions (rest, sleep, meals, physical activity) in patients treated with automated DP compared to controls, in a calorimetric chamber.

Eligibility criteria: Inclusion Criteria:

* Patients Group DPA

  * Male patients
  * Aged 18 to 70 years
  * With end-stage renal disease
  * Treated by automatic peritoneal
  * Social security cover
  * Without acute events in the 3 months prior to inclusion
  * PCR \< 30 mg/L
  * Written informed consent
  * Baecke activity score from 5 to 10

Healthy Volunteers

* Male patients
* Aged 18 to 70 years
* Patients matched by lean body mass (± 2 kgs) and age (± 5 years)
* Having a glomerular filtration rate estimated with the formula CKD-EPI creatinine \> 60 mL / min / 1.73 m 2
* PCR \< 3 mg/L
* Social security cover
* Written informed consent
* Baecke activity score from 5 to 10

Exclusion Criteria:

* • - Female

  * Type 1 or 2 diabetes requiring a antidiabetic treatment
  * Decompensated heart failure
  * Smoking more than 5 cigarettes a day
  * Alcoholic patients, drinking more than 3 glass of alcohol a day
  * Patient Corticotherapy in progress
  * Patient with evolutive acute pathology
  * Person who has participated in another study within the last 30 days or is in period of exclusion on the National File of Healthy Volunteers

Primary outcomes:
measure: Energy expenditure measured by indirect calorimetry in a calorimetric chamber
timeFrame: at day 1
Secondary outcomes:
measure: respiratory quotient (RQ)
timeFrame: at day1
measure: Actimetry
timeFrame: at day 1
measure: HGPO
timeFrame: at day 1
Other outcomes:
Locations:
city: Clermont-Ferrand
country: France
facility: CHU Clermont-Ferrand
Study officials:
affiliation: University Hospital, Clermont-Ferrand
name: Julien ANIORT
role: PRINCIPAL_INVESTIGATOR
References: