Clinical trial NCT05179811: Description of the Evolution of Functional Dysphonia Managed by Hypnotherapy
Official title: Description of the Evolution of Functional Dysphonia Managed by Hypnotherapy
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Functional Dystonia (Disorder)
Lead sponsor: Fondation Ophtalmologique Adolphe de Rothschild
Sponsor class: NETWORK
First posted: 2022-01-05
Enrollment: 14
Sex: ALL
Minimum age (years): 18
Maximum age (years): 95
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with functional dysphonia using the Voice Handicap Index score

Brief summary: HYPNODYS is a single-center study evaluating the evolution of perceived voice-related disability before and after 3 standardized hypnosis sessions in patients with functional dysphonia.

Detailed description: Functional or psychogenic voice and speech disorders are characterized by various changes in voice (aphonia or dysphonia) or speech (stuttering, foreign accent syndrome, and childish prosody in adults) without organic damage associated. These disorders have a significant functional impact (physical and mental handicap) and a significant cost for society.

Their management, like that of functional neurological disorders in general, is still poorly codified. Different therapeutic strategies are mentioned, especially in the event of speech therapy failure, in particular behavioural and cognitive psychotherapeutic approaches.

The recent explanatory hypotheses of functional neurological disorders are that the processing of sensory and motor information can be modulated, or even inhibited, by cognitive and attentional mechanisms. Different elements (volition, emotions, attention) can exclude certain psychic representations from consciousness.

Hypnosis, by exercising direct control over attentional resources makes it possible to obtain hypoactivation of the medial prefrontal cortex and hyperactivation of the executive and salience networks, making greater use of the buffer of working memory and activate the para-sympathetic system. Thus, one can observe analgesia, amnesia, a loss of the notion of time, plurimodal hallucinations, a detachment from oneself, a distortion of reality and logic.

Hypnosis has been used since the 19th century in the treatment of functional paralysis. To date, there are only presentations and case series evaluating the value of hypnosis in functional disorders of voice and speech. However, from a clinical standpoint, the use of hypnosis seems to show a significant interest in functional speech disorders.

Functional neurological disorders are located at the crossroads of neurological and psychiatric disorders, psychiatric and psychological evaluation of these patients therefore seems necessary in order to measure their impact on the pathological and recovery processes through hypnotherapy.

Eligibility criteria: Inclusion Criteria:

* Diagnosis of functional neurological disorder according to the DSM-5
* Supported at the Rothschild Foundation as part of a hypnotherapy protocol
* Mastering the understanding of the French language
* Express consent to participate in the study

Exclusion Criteria:

* Organic etiology of dysphonia
* Decompensation of a psychiatric pathology
* Discovery during study of an organic etiology not initially identified

Primary outcomes:
measure: Evolution of perceived voice related disability before and after 3 standardized hypnosis sessions
timeFrame: day 0 and 3 months after last hypnosis session
Secondary outcomes:
Other outcomes:
Locations:
city: Paris
country: France
facility: Hôpital Fondation A. de Rothschild
Study officials:
affiliation: Hôpital Fondation A. de Rothschild
name: Cécile HUBSCH
role: PRINCIPAL_INVESTIGATOR
affiliation: Hôpital Saint-Antoine
name: Stéphane MOUCHABAC
role: STUDY_DIRECTOR
References: