Clinical trial NCT03233477: Patient Registry of Posner-Schlossman Syndrome
Official title: Patient Registry of Posner-Schlossman Syndrome
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Posner Schlossman Syndrome
Keywords: Posner Schlossman Syndrome
cytokine expression
cytomegalovirus
Lead sponsor: Peking University
Sponsor class: OTHER
First posted: 2017-07-28
Enrollment: 180
Sex: ALL
Minimum age (years): 12
Maximum age (years): 80
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All the patients that visit the Peking University Third Hospital from July 2014 to July 2019 and are diognosed as Posner-Schlossman Syndrome, age-related cataract, or primary open-angle glaucoma.

Brief summary: Posner-Schlossman syndrome, or glaucomatocyclitic crisis, is a condition characterized by recurrent, acute attacks of mild, nongranulomatous, anterior uveitis accompanied by markedly elevated intraocular pressure. Most of patients are the 20 to 50-year-old young adults, with unilateral eye involvement. PSS was originally deemed benign, but is now recognized as a relatively rare cause of chronic secondary glaucoma,especially in patients with recurrent episodes. This relatively rare disease is likely the result of the infections of a variety of organisms, and the bulk of literature supports the cytomegalovirus (CMV) as the leading cause.

This study is an observational study that does not interfere with the normal clinical diagnosis and treatment process. The investigators in this study focus on observing the clinical symptoms and outcome of PSS, analyzing the factors that affect the prognosis of PSS, studying the association of its pathogenesis with the psychological status and the behavioral types of PSS patients; exploring the relationship between infection (CMV, HSV, Hp) and PSS; and studying the changes of local and systemic cytokine expression and its significance in patients with PSS.


Eligibility criteria: Inclusion Criteria:

* Volunteer to take part in this study and sign informed consent by oneself or the patient's legal representative
* Clinical diagnosis of Posner-Schlossman Syndrome, age-related cataract, or primary open-angle glaucoma
* Live in Beijing, China or being able to visit the Peking University Third Hospital every year after the beginning of the study or whenever the disease relapses

Exclusion Criteria:

* Fit any exclusion criteria of the patient's group

Primary outcomes:
measure: demographic characteristics
timeFrame: up to 10 years
measure: visual acuity
timeFrame: up to 10 years
measure: intraocular pressure
timeFrame: up to 10 years
measure: slit-lamp examination
timeFrame: up to 10 years
measure: fundus photograph
timeFrame: up to 10 years
measure: OCT
timeFrame: up to 10 years
measure: visual field
timeFrame: up to 10 years
measure: blood serum
timeFrame: up to 10 years
measure: aqueous humor
timeFrame: up to 10 years
measure: tissue
timeFrame: in the operation
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: Peking University Third Hosipital
state: Beijing
Study officials:
affiliation: Peking University Third Hospital
name: Chun Zhang, PHD，MD
role: STUDY_DIRECTOR
References: