Clinical trial NCT05439356: Colchicine in High-risk Patients With Acute Minor-to-moderate Ischemic Stroke or Transient Ischemic Attack (CHANCE-3)
Official title: Colchicine in High-risk Patients With Acute Minor-to-moderate Ischemic Stroke or Transient Ischemic Attack (CHANCE-3)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Ischemic Stroke
TIA
Lead sponsor: Beijing Tiantan Hospital
Sponsor class: OTHER
First posted: 2022-06-30
Enrollment: 8343
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: This study is a multicentre, randomized, double-blind, placebo-controlled, investigator-sponsored study that aims to investigate the efficacy of colchicine in preventing recurrent stroke in the patients with acute minor-to-moderate ischemic stroke or TIA and a hsCRP level of ≥2mg/L.

Detailed description: This is a multicentre, randomized, double-blind, placebo-controlled trial that aims to investigate the efficacy of colchicine in preventing recurrent stroke in the patients with acute minor-to-moderate ischemic stroke or TIA and a hsCRP level of ≥2mg/L. Patients who were eligible to the inclusion criteria and ineligible to the exclusion criteria will be randomly assigned into two groups by a 1:1 ratio. Patients in one arm will receive colchicine initiated with a dose of 1mg per day on days 1 through 3, and continuing with 0.5 mg per day on days 4 through 90, and those in the other arm will receive an equivalent placebo drug. Study visits will be performed on the day of randomization, at discharge, at day 90 and at 1 year. The primary outcome was stroke (ischemic or hemorrhagic) during 90 days of follow-up in an intention-to treat analysis.

Eligibility criteria: Inclusion Criteria:

1. 40 years or older than 40 years；
2. Acute cerebral ischemic event due to： Acute minor-to-moderate ischemic stroke (NIHSS≤5 at the time of randomization) or TIA with moderate-to-high risk of stroke (ABCD2 score ≥ 4 at the time of randomization)；
3. With a hsCRP level of ≥2mg/L at randomization;
4. Can be treated with study drug within 24 hours of symptoms onset\*(\*Symptom onset is defined by the "last seen normal" principle)；
5. Informed consent signed.

Exclusion Criteria:

1. Malformation, tumor, abscess or other major non-ischemic brain disease (e.g., multiple sclerosis) on baseline head CT or MRI.
2. Isolated or pure sensory symptoms (e.g., numbness), isolated visual changes, or isolated dizziness/vertigo without evidence of acute infarction on baseline head CT or MRI.
3. Iatrogenic causes (angioplasty or surgery) of stroke or TIA.
4. Presumed cardiac source of embolus, such as atrial fibrillation or prosthetic cardiac valve).
5. A score of ≥ 2 on the modified Rankin scale immediately before the occurrence of the index event.
6. Usage of colchicine within 30 days before randomization or planning to take colchicine therapy for other indications.
7. Known allergy or sensitivity or intolerance to colchicine.
8. Inflammatory bowel disease (Crohn's or ulcerative colitis) or chronic diarrhea.
9. Symptomatic peripheral neuropathy or pre-existing progressive neuromuscular disease or with creatine kinase (CK) level \> 3 times the upper limit of normal as measured within the past 30 days and determined to be non-transient through repeat testing.
10. A history of cirrhosis, chronic active hepatitis or severe hepatic disease.
11. Impaired hepatic (ALT or AST \> twice the upper limit of normal range) or kidney (creatinine exceeding 1.5 times of the upper limit of normal range or eGFR less than 50 ml/min) function at randomization.
12. Anemia (haemoglobin \<10g/dL), thrombocytopenia (platelet count \<100×109/L) or leucopenia (white blood cell \<3×109/L) at randomization.
13. In the acute phase of respiratory tract infection, urinary tract infection, and gastro-enteritis, or currently using or planning to receive oral or intravenous anti-infective therapy for any other infection.
14. Currently using or planning to begin long-term (\>7 days) systemic anti-inflammatory drugs (NSAIDs except for aspirin, oral or intravenous steroid therapy) during the study.
15. Planning to use moderate or strong CYP3A4 inhibitors (clarithromycin, erythromycin, telithromycin, other macrolide antibiotics, ketoconazole, itraconazole, voriconazole, ritonavir, atazanavir, indinavir, other HIV protease inhibitors, verapamil, diltiazem, quinidine, digoxin, disulfiram, etc) or P-gp inhibitors (cyclosporine) at randomization.
16. Planned surgery or interventional treatment requiring cessation of the study drug during the study.
17. Participating in another clinical trial with an investigational drug or device concurrently or during the last 30 days.
18. Women of childbearing age who were not practicing reliable contraception and did not have a documented negative pregnancy test or severe noncardiovascular coexisting condition.
19. Severe non-cardiovascular comorbidity with a life expectancy of less than 3 months.
20. With a history of clinically significant drug or alcohol abuse.
21. Inability to understand and/or follow research procedures due to mental, cognitive, or emotional disorders, or to be an unsuitable candidate for the study for any other considered by the investigator.

Primary outcomes:
measure: Any new stroke events
timeFrame: any time within 90 days
Secondary outcomes:
measure: New vascular events
timeFrame: any time within 90 days
measure: New ischemic stroke
timeFrame: any time within 90 days
measure: Poor functional outcome
timeFrame: at 90 days after randomization
measure: New stroke and TIA
timeFrame: any time within 90 days
measure: Severity of recurrent stroke and TIA
timeFrame: within 90 days after randomization
Other outcomes:
measure: Any new stroke events
timeFrame: any time within 1 year after randomization
measure: New vascular events
timeFrame: any time within 1 year after randomization
measure: New ischemic stroke
timeFrame: any time within 1 year after randomization
measure: Poor functional outcome
timeFrame: at 1 year after randomization
measure: New stroke and TIA
timeFrame: any time within 1 year after randomization
measure: Severity of recurrent stroke and TIA
timeFrame: within 1 year after randomization
measure: Adverse events
timeFrame: within 90 days
measure: Severe adverse events
timeFrame: within 90 days
measure: Increased CK levels or abnormal hepatic function when concomitant high-intensity statin treatment
timeFrame: within 90 days
measure: Adverse events
timeFrame: within 1 year
measure: Severe adverse events
timeFrame: within 1 year
Locations:
city: Fuyang
country: China
facility: Linquan County People's Hospital
state: Anhui
city: Huangshan
country: China
facility: Huangshan City People's Hospital
state: Anhui
city: Wuhu
country: China
facility: The First Affiliated Hospital of Wannan Medical College
state: Anhui
city: Wuhu
country: China
facility: The First People's Hospital of Wuhu
state: Anhui
city: Beijing
country: China
facility: Beijing Tiantan Hospital, Capital Medical University
state: Beijing
city: Beijing
country: China
facility: Beijing Shunyi Airport Hospital
state: Beijing
city: Beijing
country: China
facility: Beijing Shunyi Hospital
state: Beijing
city: Beijing
country: China
facility: Fuxing Hospital, Capital Medical University
state: Beijing
city: Beijing
country: China
facility: The First Hospital of Fangshan District, Beijing
state: Beijing
city: Chongqing
country: China
facility: Chongqing Sanbo Chang 'an Hospital
state: Chongqing
city: Chongqing
country: China
facility: Chongqing Tungwah Hospital
state: Chongqing
city: Chongqing
country: China
facility: Chongqing University Fuling Hospital
state: Chongqing
city: Chongqing
country: China
facility: The First Affiliated Hospital of Chongqing Medical and Pharmaceutical College
state: Chongqing
city: Chongqing
country: China
facility: The Second Affiliated Hospital of Chongqing Medical University
state: Chongqing
city: Chongqing
country: China
facility: Xiushan Tujia and Miao Autonomous County People's Hospital
state: Chongqing
city: Ningde
country: China
facility: Ningde People's Hospital
state: Fujian
city: Sanming
country: China
facility: The Sanming First Hospital Affiliated to Fujian Medical University
state: Fujian
city: Xiamen
country: China
facility: The First Affiliated Hospital of Xiamen University
state: Fujian
city: Xiamen
country: China
facility: The Second affiliated Hospital of Xiamen Medical College
state: Fujian
city: Xiamen
country: China
facility: The Third Hospital of Xiamen
state: Fujian
city: Lanzhou
country: China
facility: The First People's Hospital of Lanzhou City
state: Gansu
city: Zhangye
country: China
facility: Zhangye People's Hospital Affiliated To Hexi University
state: Gansu
city: Foshan
country: China
facility: The First People's Hospital of Foshan
state: Guangdong
city: Guangzhou
country: China
facility: Guangdong second Provincial Central Hospital
state: Guangdong
city: Guangzhou
country: China
facility: The First Affiliated Hospital of Jinan University
state: Guangdong
city: Heyuan
country: China
facility: The Fifth Affiliated Hospital of Jinan University (Heyuan Shenhe People's Hospital)
state: Guangdong
city: Huizhou
country: China
facility: Huizhou First Hospital
state: Guangdong
city: Baise
country: China
facility: Baise City People's Hospital
state: Guangxi
city: Wuzhou
country: China
facility: The People's Hospital of Cenxi City
state: Guangxi
city: Guizhou
country: China
facility: Guihang Guiyang hospital
state: Guiyang
city: Anshun
country: China
facility: Puding County People's Hospital
state: Guizhou
city: Bijie
country: China
facility: Zhejiang Provincial People's Hospital Bijie Hospital
state: Guizhou
city: Guiyang
country: China
facility: The First People's Hospital of Guiyang
state: Guizhou
city: Guiyang
country: China
facility: The Second People's Hospital of Guiyang
state: Guizhou
city: Guiyang
country: China
facility: The Third People's Hospital of Guiyang
state: Guizhou
city: Kaili
country: China
facility: The People's Hospital of the Qiandongnan Miao and Dong Autonomous Prefecture
state: Guizhou
city: Kaili
country: China
facility: The second Affiliated Hospital of Guizhou Medical University
state: Guizhou
city: Xingyi
country: China
facility: Qianxinan Buyi and Miao Autonomous Prefecture People's Hospital
state: Guizhou
city: Haikou
country: China
facility: The Second Affiliated Hospital of Hainan Medical University
state: Hainan
city: Baoding
country: China
facility: Affiliated Hospital of Hebei University
state: Hebei
city: Baoding
country: China
facility: Baoding Xushui District People's Hospital
state: Hebei
city: Baoding
country: China
facility: Hebei Tang County People Hospital
state: Hebei
city: Baoding
country: China
facility: Shunping County Hospital
state: Hebei
city: Baoding
country: China
facility: The Hospital of Anguo City
state: Hebei
city: Baoding
country: China
facility: Wangdu County Hospital,Hebei Province
state: Hebei
city: Chengde
country: China
facility: Affiliated Hospital of Chengde Medical University
state: Hebei
city: Chengde
country: China
facility: Chengde County Hospital
state: Hebei
city: Handan
country: China
facility: Guantao county central Hospital
state: Hebei
city: Handan
country: China
facility: Handan First Hospital
state: Hebei
city: Handan
country: China
facility: Qiu County Hospital of Traditional Chinese Medicine
state: Hebei
city: Handan
country: China
facility: Qiu County People's Hospital
state: Hebei
city: Hejian
country: China
facility: Hejian People's Hospital
state: Hebei
city: Hengshui
country: China
facility: Hengshui People's Hospital
state: Hebei
city: Hengshui
country: China
facility: The No.4 People's Hospital of Hengshui(Department of Neurology ward 1)
state: Hebei
city: Hengshui
country: China
facility: The No.4 People's Hospital of Hengshui(Department of Neurology ward 2)
state: Hebei
city: Shijiazhuang
country: China
facility: Shijiazhuang Third Hospital
state: Hebei
city: Shijiazhuang
country: China
facility: The Second Hospital of Hebei Medical University
state: Hebei
city: Tangshan
country: China
facility: North China University of Science And Technology Affiliated Hospital
state: Hebei
city: Tangshan
country: China
facility: Tangshan Gongren Hospital
state: Hebei
city: Xingtai
country: China
facility: Qinghe people's hospital
state: Hebei
city: Xingtai
country: China
facility: Werixian People's Hospital
state: Hebei
city: Zhangjiakou
country: China
facility: The First Affiliated Hospital of Hebei North University
state: Hebei
city: Harbin
country: China
facility: The 2nd Affiliated Hospital of Harbin Medical University
state: Heilongjiang
city: Harbin
country: China
facility: The First Affiliated Hospital of Harbin Medical University
state: Heilongjiang
city: Shuangyashan
country: China
facility: Hongxinglong Hospital of Beidahuang Group
state: Heilongjiang
city: Anyang
country: China
facility: The People's Hospital of Anyang City
state: Henan
city: Dezhou
country: China
facility: Dengzhou Central Hospital
state: Henan
city: Hebi
country: China
facility: Hebi Coal Industry (Group) Co., Ltd. General Hospital
state: Henan
city: Jiaozuo
country: China
facility: Boai People's Hospital
state: Henan
city: Jiaozuo
country: China
facility: Mengzhou Hospital of Traditional Chinese Medicine
state: Henan
city: Jiaozuo
country: China
facility: Mengzhou People's Hospital(Department of Neurology ward 1)
state: Henan
city: Jiaozuo
country: China
facility: Mengzhou People's Hospital(Department of Neurology ward 2)
state: Henan
city: Jiaozuo
country: China
facility: Qinyang City Hospital of Traditional Chinese Medicine
state: Henan
city: Jiaozuo
country: China
facility: Qinyang People's Hospital
state: Henan
city: Jiaozuo
country: China
facility: Wuzhi County People's Hospital
state: Henan
city: Jiaozuo
country: China
facility: Xiuwu County People's Hospital
state: Henan
city: Jiyuan
country: China
facility: Jiyuan Hospital of Traditional Chinese Medicine
state: Henan
city: Kaifeng
country: China
facility: Kaifeng Central Hospital
state: Henan
city: Kaifeng
country: China
facility: Lankao County Central Hospital
state: Henan
city: Kaifeng
country: China
facility: Weishi Central Hospital
state: Henan
city: Luoyang
country: China
facility: Luoning County People's Hospital
state: Henan
city: Luoyang
country: China
facility: Luoyang Central Hospital
state: Henan
city: Luoyang
country: China
facility: Luoyang Dongfang People's Hospital
state: Henan
city: Luoyang
country: China
facility: Luoyang First People's Hospital
state: Henan
city: Luoyang
country: China
facility: Luoyang Mengjin District People's Hospital
state: Henan
city: Luoyang
country: China
facility: Ruyang People's Hospital
state: Henan
city: Luoyang
country: China
facility: The Second Affiliated Hospital of Henan University of Science and Technology
state: Henan
city: Luoyang
country: China
facility: Yiyang County People's Hospital
state: Henan
city: Nanyang
country: China
facility: Nanyang Second General Hospital
state: Henan
city: Nanyang
country: China
facility: Neixiang County People's Hospital
state: Henan
city: Nanyang
country: China
facility: Xichuan County People's Hospital
state: Henan
city: Nanyang
country: China
facility: Xixia County People's Hospital
state: Henan
city: Pingdingshan
country: China
facility: Ruzhou People's Hospital
state: Henan
city: Pingdingshan
country: China
facility: The second people's hospital of Pingdingshan
state: Henan
city: Pingdingshan
country: China
facility: Ye County People's Hospital
state: Henan
city: Puyang
country: China
facility: Fanxian People's Hospital
state: Henan
city: Puyang
country: China
facility: Puyang County People's Hospital
state: Henan
city: Puyang
country: China
facility: Qingfeng xinxing hospital
state: Henan
city: Sanmenxia
country: China
facility: The First People Hospital of Lingbao
state: Henan
city: Shangqiu
country: China
facility: Sui county traditional Chinese medicine hospital
state: Henan
city: Shangqiu
country: China
facility: The Fourth People's Hospital of Shangqiu
state: Henan
city: Shangqiu
country: China
facility: The Shangqiu First People's Hospital
state: Henan
city: Shangqiu
country: China
facility: Zhecheng People's Hospital
state: Henan
city: Xinxiang
country: China
facility: Huixian People's Hospital
state: Henan
city: Xinxiang
country: China
facility: The second People Hospital of Xinxiang Henan
state: Henan
city: Xinxiang
country: China
facility: Xinxiang tongmeng hospital
state: Henan
city: Xinyang
country: China
facility: The Affiliated Hospital of Xinyang Vocational and Technical College
state: Henan
city: Yongcheng
country: China
facility: Central Hospital of Yongcheng
state: Henan
city: Zhengzhou
country: China
facility: Xingyang People's Hospital
state: Henan
city: Zhengzhou
country: China
facility: Xinmi Hospital of T.C.M
state: Henan
city: Zhoukou
country: China
facility: Shenqiu County People's Hospital
state: Henan
city: Zhoukou
country: China
facility: Taikang Xian People's Hospital
state: Henan
city: Zhoukou
country: China
facility: Xihua Xian People's Hospital
state: Henan
city: Zhumadian
country: China
facility: Zhumadian TCM Hospital
state: Henan
city: Chenzhou
country: China
facility: Chenzhou No.1 People's Hospital
state: Hunan
city: Chenzhou
country: China
facility: The Fourth People's Hospital of Chenzhou
state: Hunan
city: Chenzhou
country: China
facility: The Third People's Hospital of Chenzhou
state: Hunan
city: Hengyang
country: China
facility: Hengyang Central Hospital
state: Hunan
city: Shaoyang
country: China
facility: Shaodong People's Hospital
state: Hunan
city: Yueyang
country: China
facility: Yueyang People's Hospital
state: Hunan
city: Baotou
country: China
facility: Baotou City Central Hospital
state: Inner Mongolia
city: Baotou
country: China
facility: Sinopharm North Hospital
state: Inner Mongolia
city: Baotou
country: China
facility: The First Affiliated Hospital of Baotou Medical College
state: Inner Mongolia
city: Bayan Nur
country: China
facility: The people's Hospital of Wulateqianqi
state: Inner Mongolia
city: Bayan Nur
country: China
facility: Wuyuan County People's Hospital
state: Inner Mongolia
city: Hohhot
country: China
facility: Huhhot First Hospital
state: Inner Mongolia
city: Hohhot
country: China
facility: Inner Mongolia International Mongolian Hospital
state: Inner Mongolia
city: Hohhot
country: China
facility: Inner Mongolia People's Hospital
state: Inner Mongolia
city: Hulunbuir
country: China
facility: Inner Mongolia Forestry General Hospital
state: Inner Mongolia
city: Ordos
country: China
facility: Ordos central hospital
state: Inner Mongolia
city: Tongliao
country: China
facility: Affiliated Hospital of Inner Mongolia Minzu University
state: Inner Mongolia
city: Tongliao
country: China
facility: Tongliao City Hospital
state: Inner Mongolia
city: Ulanqab
country: China
facility: Ulanpab Central Hospital
state: Inner Mongolia
city: Wuhai
country: China
facility: The people's Hospital of Wuhai
state: Inner Mongolia
city: Hohhot
country: China
facility: Tuoketuo County Hospital
state: Inner Mongoria
city: Nanjing
country: China
facility: Nanjing Gaochun People's Hospital
state: Jiangsu
city: Nantong
country: China
facility: Jiangsu Rudong County People's Hospital
state: Jiangsu
city: Nantong
country: China
facility: Nantong Tongzhou District No.8 People's Hospital
state: Jiangsu
city: Nantong
country: China
facility: Suxitong Science and Technology Industrial Park People's Hospital
state: Jiangsu
city: Nantong
country: China
facility: The People's Hospital of Rugao
state: Jiangsu
city: Nantong
country: China
facility: The Sixth People's Hospital of Nantong
state: Jiangsu
city: Suqian
country: China
facility: Nanjing Drum Tower Hospital Group Suqian Hospital
state: Jiangsu
city: Suqian
country: China
facility: Siyang kangda hospital
state: Jiangsu
city: Taizhou
country: China
facility: Xinghua City People's Hospital
state: Jiangsu
city: Wuxi
country: China
facility: Jiangyin People's Hospital
state: Jiangsu
city: Wuxi
country: China
facility: Yixing People's Hospital
state: Jiangsu
city: Xuzhou
country: China
facility: The Second Affiliated Hospital of Xuzhou Medical University
state: Jiangsu
city: Fuzhou
country: China
facility: Fuzhou First People's Hospital of Jiangxi Province
state: Jiangxi
city: Ganzhou
country: China
facility: Nanfang Hospital，Ganzhou
state: Jiangxi
city: Jingdezhen
country: China
facility: Jingdezhen No.1 People's Hospital
state: Jiangxi
city: Jiujiang
country: China
facility: Jiujiang No.1 People's Hospital
state: Jiangxi
city: Jiujiang
country: China
facility: Jiujiang University Affiliated Hospital
state: Jiangxi
city: Nanchang
country: China
facility: Jiangxi Provincial People's Hospital
state: Jiangxi
city: Shangrao
country: China
facility: ShangRao People's Hospital
state: Jiangxi
city: Shangrao
country: China
facility: Yugan Xinjiang hospital
state: Jiangxi
city: Yichun
country: China
facility: Tonggu County People's Hospital
state: Jiangxi
city: Yichun
country: China
facility: Yichun People's Hospital
state: Jiangxi
city: Changchun
country: China
facility: China-Japan Union Hospital of Jilin University
state: Jilin
city: Meihekou
country: China
facility: Meihekou Central Hospital
state: Jilin
city: Siping
country: China
facility: Siping Central People's Hospital
state: Jilin
city: Anshan
country: China
facility: Anshan Central Hospital
state: Liaoning
city: Dalian
country: China
facility: Affiliated Zhongshan Hospital of Dalian University
state: Liaoning
city: Dalian
country: China
facility: Central Hospital of Wafangdian
state: Liaoning
city: Dalian
country: China
facility: Central Hospital of Zhuanghe City
state: Liaoning
city: Dalian
country: China
facility: Dalian Jinzhou District First People's Hospital
state: Liaoning
city: Dalian
country: China
facility: Dalian Lvshun District Hospitai of tradition Chinese Medicine
state: Liaoning
city: Dalian
country: China
facility: Dalian Lvshun District People's Hospital
state: Liaoning
city: Dalian
country: China
facility: Dalian Municipal Central Hospital
state: Liaoning
city: Dalian
country: China
facility: Dalian PuLanDian central hospital
state: Liaoning
city: Dalian
country: China
facility: Dalian University Affiliated Xinhua Hospital
state: Liaoning
city: Huludao
country: China
facility: The Second People's Hospital of Huludao
state: Liaoning
city: Panjin
country: China
facility: Panjin Central Hospital
state: Liaoning
city: Shenyang
country: China
facility: Affiliated Hospital of Liaoning University of Traditional Chinese Medicine
state: Liaoning
city: Shenyang
country: China
facility: Shengjing Hospital of China Medical University
state: Liaoning
city: Shenyang
country: China
facility: The People's Hospital of Liaoning Province
state: Liaoning
city: Guyuan
country: China
facility: Guyuan people's hospital
state: Ningxia
city: Zhongwei
country: China
facility: People's Hospital of Zhongwei
state: Ningxia
city: Ankang
country: China
facility: Ankang Central Hospital
state: Shaanxi
city: Xi'an
country: China
facility: East District of The First Affiliated Hospital of Xi'an Jiaotong University
state: Shaanxi
city: Xi'an
country: China
facility: Xi 'an Fengcheng Hospital
state: Shaanxi
city: Xianyang
country: China
facility: Xianyang Hospital of Yan 'an University
state: Shaanxi
city: Yanan
country: China
facility: Zichang People's Hospital
state: Shaanxi
city: Weihai
country: China
facility: Weihai Wendeng District People's Hospital
state: Shandogn
city: Binzhou
country: China
facility: Binzhou Central Hospital
state: Shandong
city: Binzhou
country: China
facility: Yangxin County People Hospital
state: Shandong
city: Dezhou
country: China
facility: Ningjin People's Hospital
state: Shandong
city: Dezhou
country: China
facility: People's Hospital of Qihe County
state: Shandong
city: Dongying
country: China
facility: The Second People's Hospital of Dongying
state: Shandong
city: Heze
country: China
facility: Yuncheng County People's Hospital
state: Shandong
city: Jinan
country: China
facility: Affiliated Hospital of Shandong University of Traditional Chinese Medicine
state: Shandong
city: Liaocheng
country: China
facility: Guanxian People's Hospital
state: Shandong
city: Liaocheng
country: China
facility: Liaocheng City Central Hospital
state: Shandong
city: Liaocheng
country: China
facility: Liaocheng People's Hospital
state: Shandong
city: Liaocheng
country: China
facility: Liaocheng People's Hospital（Liaocheng Brain Hospital）
state: Shandong
city: Liaocheng
country: China
facility: The People's Hospital of Gaotang
state: Shandong
city: Liaocheng
country: China
facility: The people's Hospital of Linqing
state: Shandong
city: Liaocheng
country: China
facility: The Second People's Hospital of Liaocheng
state: Shandong
city: Liaocheng
country: China
facility: Third People's Hospital of Liaocheng
state: Shandong
city: Liaocheng
country: China
facility: Yanggu Traditional Chinese Medical Hospital
state: Shandong
city: Linyi
country: China
facility: Linyi Central Hospital
state: Shandong
city: Linyi
country: China
facility: Linyi People's Hospital
state: Shandong
city: Linyi
country: China
facility: Linyi Third People's Hospital
state: Shandong
city: Linyi
country: China
facility: Linyi Traditional Chinese Medicine Hospital
state: Shandong
city: Linyi
country: China
facility: People's Hospital of Yinan
state: Shandong
city: Qingdao
country: China
facility: Qingdao Fuwai Cardiovascular Hospital
state: Shandong
city: Qixian
country: China
facility: Qixia City People's Hospital
state: Shandong
city: Weihai
country: China
facility: Weihai Central Hospital
state: Shandong
city: Weihai
country: China
facility: Weihai Municipal Hospital
state: Shandong
city: Yantai
country: China
facility: Qixia traditional Chinese medicine hospital
state: Shandong
city: Yantai
country: China
facility: Yantai Affiliated Hospital of Binzhou Medical University
state: Shandong
city: Yantai
country: China
facility: Yantai Penglai People's Hospital
state: Shandong
city: Yantai
country: China
facility: Yantai Penglai traditional Chinese medicine hospital
state: Shandong
city: Yantai
country: China
facility: Yantai Taocun Central Hospital
state: Shandong
city: Yantai
country: China
facility: Yantai Yuhuangding Hospital
state: Shandong
city: Yantai
country: China
facility: Yantai Zhifu hospital
state: Shandong
city: Yantai
country: China
facility: YEDA hospital
state: Shandong
city: Zaozhuang
country: China
facility: Yicheng Municipal Hospital of Zaozhuang
state: Shandong
city: Zibo
country: China
facility: PKUcare Zibo Hospital
state: Shandong
city: Zibo
country: China
facility: Zibo Central Hospital
state: Shandong
city: Zibo
country: China
facility: Zibo Hospital of Traditional Chinese Medicine
state: Shandong
city: Zibo
country: China
facility: Zibo Municipal Hospital
state: Shandong
city: Shanghai
country: China
facility: Shanghai Seventh People's Hospital
state: Shanghai
city: Shanghai
country: China
facility: Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine
state: Shanghai
city: Linfen
country: China
facility: Linfen Central Hospital (neurology department)
state: Shanxi
city: Linfen
country: China
facility: Linfen Central Hospital(emergency department)
state: Shanxi
city: Taiyuan
country: China
facility: Second Hospital of Shanxi Medical University
state: Shanxi
city: Taiyuan
country: China
facility: Shanxi Bethune Hospital
state: Shanxi
city: Taiyuan
country: China
facility: Shanxi Cardiovascular Hospital
state: Shanxi
city: Chengdu
country: China
facility: Sichuan Provincial People's Hospital
state: Sichuan
city: Chengdu
country: China
facility: The First People's Hospital of Longquanyi Disdrict,Chengdu
state: Sichuan
city: Deyang
country: China
facility: People's Hospital of Deyang City
state: Sichuan
city: Mianyang
country: China
facility: The Third Hospital of Mianyang
state: Sichuan
city: Neijiang
country: China
facility: The Second People's Hospital of Neijiang
state: Sichuan
city: Panzhihua
country: China
facility: Panzhihua Central Hospital
state: Sichuan
city: Shihezi
country: China
facility: The First Affiliated Hospital of Shihezi University
state: Xinjiang
city: Urumqi
country: China
facility: People's Hospital of Xinjiang Uygur Autonomous Region, Urumqi, China
state: Xinjiang
city: Kunming
country: China
facility: First Affiliated Hospital of Kunming Medical University
state: Yunnan
city: Nujiang
country: China
facility: Yunnan Nujiang Lisu Autonomous Prefecture People's Hospital
state: Yunnan
city: Pu'er
country: China
facility: Ninger County People's Hospital
state: Yunnan
city: Tengchong
country: China
facility: Tengchong People's Hospital
state: Yunnan
city: Hangzhou
country: China
facility: The First People's Hospital of jiande
state: Zhejiang
city: Huzhou
country: China
facility: People's Hospital of Anji
state: Zhejiang
city: Jiaxing
country: China
facility: Haiyan People's Hospital
state: Zhejiang
city: Heze
country: China
facility: Juancheng County People's Hospital
Study officials:
References: