Clinical trial NCT00295997: Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer, Metastatic Kidney Cancer, or Aplastic Anemia
Official title: Non-myeloablative Allogeneic Stem Cell Transplantation With Match Unrelated Donors for Treatment of Hematologic Malignancies and Renal Cell Carcinoma and Aplastic Anemia
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Chronic Myeloproliferative Disorders
Kidney Cancer
Leukemia
Lymphoma
Multiple Myeloma and Plasma Cell Neoplasm
Myelodysplastic Syndromes
Myelodysplastic/Myeloproliferative Neoplasms
Keywords: adult acute myeloid leukemia with 11q23 (MLL) abnormalities
adult acute myeloid leukemia with inv(16)(p13;q22)
adult acute myeloid leukemia with t(15;17)(q22;q12)
adult acute myeloid leukemia with t(16;16)(p13;q22)
accelerated phase chronic myelogenous leukemia
adult acute lymphoblastic leukemia in remission
adult acute myeloid leukemia in remission
atypical chronic myeloid leukemia, BCR-ABL1 negative
blastic phase chronic myelogenous leukemia
childhood acute lymphoblastic leukemia in remission
childhood acute myeloid leukemia in remission
childhood chronic myelogenous leukemia
chronic eosinophilic leukemia
primary myelofibrosis
chronic myelomonocytic leukemia
chronic neutrophilic leukemia
chronic phase chronic myelogenous leukemia
de novo myelodysplastic syndromes
essential thrombocythemia
juvenile myelomonocytic leukemia
myelodysplastic/myeloproliferative neoplasm, unclassifiable
polycythemia vera
previously treated myelodysplastic syndromes
recurrent adult acute myeloid leukemia
prolymphocytic leukemia
recurrent adult Hodgkin lymphoma
recurrent adult diffuse large cell lymphoma
recurrent adult immunoblastic large cell lymphoma
recurrent adult lymphoblastic lymphoma
recurrent/refractory childhood Hodgkin lymphoma
recurrent childhood acute lymphoblastic leukemia
recurrent childhood acute myeloid leukemia
recurrent childhood large cell lymphoma
recurrent grade 1 follicular lymphoma
recurrent grade 2 follicular lymphoma
recurrent grade 3 follicular lymphoma
recurrent mantle cell lymphoma
refractory chronic lymphocytic leukemia
refractory multiple myeloma
relapsing chronic myelogenous leukemia
secondary acute myeloid leukemia
secondary myelodysplastic syndromes
stage II multiple myeloma
stage III chronic lymphocytic leukemia
stage III grade 1 follicular lymphoma
stage III grade 2 follicular lymphoma
stage III grade 3 follicular lymphoma
stage III multiple myeloma
stage IV chronic lymphocytic leukemia
stage IV grade 1 follicular lymphoma
stage IV grade 2 follicular lymphoma
stage IV grade 3 follicular lymphoma
recurrent renal cell cancer
stage IV renal cell cancer
noncontiguous stage II grade 1 follicular lymphoma
noncontiguous stage II grade 2 follicular lymphoma
noncontiguous stage II grade 3 follicular lymphoma
recurrent adult acute lymphoblastic leukemia
childhood myelodysplastic syndromes
Lead sponsor: National Cancer Institute (NCI)
Sponsor class: NIH
Collaborators: name: National Cancer Institute (NCI)
First posted: 2006-02-24
Enrollment: 35
Sex: ALL
Maximum age (years): 74
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Primary purpose: TREATMENT

Brief summary: RATIONALE: Giving low doses of chemotherapy before a donor stem cell transplant using stem cells that closely match the patient's stem cells, helps stop the growth of cancer cells. It also stops the patient's immune system from rejecting the donor's stem cells. The donated stem cells may replace the patient's immune system and help destroy any remaining cancer cells (graft-versus-tumor effect). Giving an infusion of the donor's T cells (donor lymphocyte infusion) after the transplant may help increase this effect. Sometimes the transplanted cells from a donor can also make an immune response against the body's normal cells. Giving antithymocyte globulin before transplant and cyclosporine and mycophenolate mofetil after transplant may stop this from happening.

PURPOSE: This clinical trial is studying how well a donor stem cell transplant works in treating patients with hematologic cancer, metastatic kidney cancer, or aplastic anemia.

Detailed description: OBJECTIVES:

Primary

* Determine the treatment-related mortality (TRM) rate at 100 days in patients with hematologic malignancy, metastatic renal cell carcinoma, or aplastic anemia undergoing nonmyeloablative allogeneic stem cell transplantation using matched unrelated donors.

Secondary

* Determine the TRM at 12 months in patients treated with this regimen.
* Determine the 6-month engraftment rate in patients treated with this regimen.
* Determine 1-year overall survival of patients treated with this regimen.

OUTLINE:

* Nonmyeloablative preparative regimen: Patients receive fludarabine IV over 30 minutes on days -7 to -3, busulfan\* IV over 6 hours on days -4 and -3, and anti-thymocyte globulin IV over 6-10 hours on days -4 to -1.

NOTE: \*Patients with aplastic anemia receive cyclophosphamide IV over 2 hours on days -6 to -3 instead of busulfan.

* Allogeneic stem cell reinfusion: Patients undergo allogeneic bone marrow or peripheral blood stem cell transplantation on day 0. Patients then receive filgrastim (G-CSF) subcutaneously daily beginning on day 7 and continuing until blood counts recover.
* Graft-vs-host disease (GVHD) prophylaxis: Patients receive tacrolimus orally twice daily or IV continuously beginning on day -2 and continuing for approximately for 6-12 months after transplantation. Patients also receive mycophenolate mofetil orally or IV twice daily on days 0 to 60 and methotrexate IV on days 1, 3, 6, and 11\*\*.

NOTE: \*\*Patients with aplastic anemia receive methotrexate IV on days 1, 3, and 6 (not day 11).

* Donor lymphocyte infusion (DLI): After day 180, patients with no evidence of active GVHD may receive DLI. A second DLI may be infused \> 8 weeks after the first in the absence of disease response or GVHD.

After completion of study treatment, patients are followed periodically for at least 2 years.

PROJECTED ACCRUAL: A total of 35 patients will be accrued for this study.

Eligibility criteria: DISEASE CHARACTERISTICS:

* Diagnosis of 1 of the following:

  * Aplastic anemia not responsive to immunosuppressive therapy
  * Metastatic renal cell carcinoma
  * Hematologic malignancy, including any of the following:

    * Acute myeloid leukemia (AML)\* not curable with chemotherapy and meeting any of the following criteria:

      * AML with high-risk cytogenetic abnormalities (e.g., -7, -7q, -5, -5q, complex, Philadelphia chromosome-positive \[Ph+\])
      * AML evolved from prior myelodysplasia
      * AML secondary to prior chemotherapy
      * Failed to achieve remission
      * In second or subsequent remission NOTE: \*Marrow blasts \< 10%- can be achieved by chemotherapy
    * Myelodysplasia\* with any of the following high-risk features:

      * Adverse cytogenetics (-7, 7q, -5, -5q, complex)
      * Excess blasts
      * Prior conversion to AML
      * Severe cytopenias with absolute neutrophil count \< 500/mm\^3 or platelet count \< 20,000/mm\^3 NOTE: \*Marrow blasts \< 10%- can be achieved by chemotherapy
    * Acute lymphoblastic leukemia (ALL)\* not curable with chemotherapy and meeting any of the following criteria:

      * High-risk cytogenetics (Ph+, 11q23 abnormalities, monosomy 7)
      * More than 1 induction course required to achieve remission
      * Failed to enter remission
      * In second or subsequent remission NOTE: \*Marrow blasts \< 10 %
    * Chronic lymphocytic leukemia (CLL) with high-risk features, including any of the following:

      * Refractory to initial or subsequent therapy
      * Progression after initial response to therapy
      * Prolymphocytic morphology
    * Follicular lymphoma with any of the following high-risk features:

      * Refractory to initial or subsequent therapy
      * Progression after response to initial therapy
      * Has ≥ 3 International Prognostic Index (IPI) risk factors
    * Multiple myeloma

      * Stage II-III disease confirmed at diagnosis or after initial progression
    * Other lymphoma that has failed to respond to primary therapy, progressed, or recurred after prior therapy, including any of the following:

      * Diffuse large cell lymphoma
      * Mantle cell lymphoma
      * Hodgkin's lymphoma
    * Myeloproliferative disease with evidence of disease acceleration, including any of the following:

      * Myelofibrosis
      * Polycythemia vera
      * Essential thrombocythemia
    * Chronic myeloid leukemia (CML) that failed to be controlled by imatinib mesylate
* Disease must be stable or responding to therapy
* No rapid progression of malignant disease

  * Expected time to disease progression \> 12 weeks
* Not eligible for autologous stem cell transplantation
* Matched unrelated donor available

  * 9/10 HLA matched, including HLA-A, -B, -C, -DR, and -DQ

PATIENT CHARACTERISTICS:

* Creatinine \< 2.0 mg/dL
* Creatinine clearance \> 40 mL/min
* Bilirubin \< 3 mg/dL

  * Elevated total bilirubin due to Gilbert's disease allowed if direct bilirubin is normal
* AST \< 4 times upper limit of normal
* Hepatitis C or B allowed provided bilirubin and AST are normal
* Cardiac ejection fraction \> 30%
* DLCO \> 40% of predicted
* Not pregnant or nursing
* Negative pregnancy test
* Fertile patients must use effective contraception
* No uncontrolled active infection requiring ongoing antibiotic treatment
* No poor performance status
* No poor organ function

PRIOR CONCURRENT THERAPY:

* See Disease Characteristics
* Prior stem cell or bone marrow transplantation allowed

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: San Francisco
country: United States
facility: UCSF Comprehensive Cancer Center
state: California
city: Winston-Salem
country: United States
facility: Wake Forest University Comprehensive Cancer Center
state: North Carolina
Study officials:
affiliation: University of California, San Francisco
name: Charles A. Linker, MD
role: PRINCIPAL_INVESTIGATOR
References: