louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02127554: Long Term Results and Complications After Epistaxis Treatment
Official title: Langzeitresultate Und Komplikationen Nach Einer Epistaxisbehandlung
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Nosebleed (Epistaxis) - Posterior or Anterior
Lead sponsor: University of Zurich
Sponsor class: OTHER
First posted: 2014-04-30
Enrollment: 591
Sex: ALL
Minimum age (years): 14
Maximum age (years): 80
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients treated between March 29, 2007 and April 1st, 2008 for epistaxis at the ENT Dept. of the Zurich University Hospital

Brief summary: The aim of this study is to find the most agreeable and in the long term most efficient treatment for epistaxis.

Detailed description: In the general population epistaxis occurs quite frequently. Approximately 60% of persons will be affected once in their lifetime, and 6% thereof will seek medical advice. Thereby anterior and posterior epistaxis are discerned. Anterior epistaxis is usually located at the Locus Kisselbachii, while posterior bleeds are found further back in the nose. There, most bleeds will originate from the A. sphenopalatina or the A. ethmoidalis.

Different treatment modalities exist. Anterior epistaxis are usually easier to treat than posterior ones. The aim of this study is to find the most efficient treatment. This involves the assessment of long term results and potential sequelae. Existing data will be complemented with information about recurrences and complications. The question is: Which treatment method leads to the least numbers of recurrences in the long term with the fewest long term sequelae?

Secondly, the most agreeable, least painful treatment method is to be identified. Therefore we will send out questionnaires to patients that were treated between March 29, 2007 and April 1st, 2008 at the Zurich University Hospital.

Eligibility criteria: Inclusion Criteria:

All patients treated during the study period with known address and who did not decease in the meantime.

Exclusion Criteria:

Insufficiently filled out questionnaires; Obvious lack of ability to remember (as tested by control questions); Known mental disability

Primary outcomes:
measure: Number of patients without recurrence
timeFrame: Up to 8 years post-treatment
Secondary outcomes:
measure: Discomfort caused by treatment
timeFrame: Up to 1 day post-treatment
Other outcomes:
measure: Number of complications due to treatment
timeFrame: Up to 8 years post-treatment
measure: Sequelae due to treatment
timeFrame: Up to 8 years post-treatment
Locations:
city: Zurich
country: Switzerland
facility: Zurich University Hospital
Study officials:
affiliation: Zurich University Hospital
name: Michael Soyka, Dr.med.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03058354: Study to Investigate TIVA With Propofol on Postoperative Pain and Side Effects
Official title: Retrospective Study to Investigate Total Intravenous Anaesthesia (TIVA) With Propofol on Postoperative Pain and Side Effects After Surgery
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Postoperative Pain
Lead sponsor: The University of Hong Kong
Sponsor class: OTHER
First posted: 2017-02-20
Enrollment: 0
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients undergoing surgery at Queen Mary Hospital, Hong Kong between 2014 to 2016.

Brief summary: Propofol is a commonly used anaesthetic with rapid recovery and less side effects and total intravenous anaesthesia (TIVA) with propofol is a common technique now. The reduction on certain serum pro- inflammatory cytokines may lead to more smooth post- surgical recovery.

Recent case report proved the analgesic effect of propofol infusion. However other animal and clinical studies showed controversial result.

The aim of this retrospective study is to investigate the postoperative analgesic effects and side effects of intraoperative TIVA with propofol in patient undergoing surgery at Queen Mary Hospital, Hong Kong between 2014 to 2016.

Detailed description: Objectives:

1. To investigate the analgesic effects of propofol.
2. To evaluate the effect of propofol on postoperative adverse events.

Methods:

Retrospective audit.

Data Collection:

1. Demographic data;
2. Types of analgesic techniques;
3. Type of pain relief modalities;
4. Pain score up to 72 hours postoperatively;
5. Postoperative opioid consumption;
6. Incidence of adverse events during APS care;
7. Patients' satisfaction on pain relief.

Eligibility criteria: Inclusion Criteria:

* Anaesthetic records and acute pain service records of patient undergone surgery between 2014 to 2016 in Queen Mary Hospital would be retrieved from the computer.

Exclusion Criteria:

* Essential data were missing.
* Patient participating in other research projects.
* Changes in postoperative pain management technique.
* Patients could not be assessed post-operatively for pain (i.e. post-operative IPPV)

Primary outcomes:
measure: pain score
timeFrame: up to postoperative day 3
Secondary outcomes:
measure: analgesic consumption
timeFrame: up to postoperative day 3
Other outcomes:
Locations:
city: Hong Kong
country: Hong Kong
facility: The University of Hong Kong
Study officials:
affiliation: The University of Hong Kong
name: Stanley SC Wong, MBBS
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03094754: Excision Size and Location on the Postoperative Pain After Nevi Excision in Children
Official title: Effect of Excised Surface Area/Body Surface Area Ratio and Location of Excision on the Postoperative Pain After Nevi Excision in Children: Observational Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Anesthesia, Endotracheal
Lead sponsor: Ajou University School of Medicine
Sponsor class: OTHER
First posted: 2017-03-29
Enrollment: 100
Sex: ALL
Minimum age (years): 1
Maximum age (years): 7
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: children undergoing nevi excision on general anesthesia

Brief summary: The primary purpose of this study is to investigate the effects of excised surface area/body surface area ratio and location of excision on the postoperative pain after nevi excision in children.

The primary purpose of this study is to investigate the effects of excised surface area/body surface area ratio and location of excision on the emergence excitation after nevi excision in children.


Eligibility criteria: Inclusion Criteria:

* children undergoing nevi excision on general anesthesia

Exclusion Criteria:

* development disorder
* neurological disorder
* psychological disorder

Primary outcomes:
measure: postoperative pain score
timeFrame: up to 3 hours
Secondary outcomes:
measure: emergence agitation score
timeFrame: up to 3 hours
Other outcomes:
Locations:
city: Suwon
country: Korea, Republic of
facility: Department of Anesthesiology and Pain Medicine, Ajou University School of Medicine
state: Seoum
Study officials:
References:
Clinical trial NCT03391154: Efficacy of Low Dose Levothyroxine During Pregnancy
Official title: Efficacy of Low Dose Levothyroxine During Pregnancy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Euthyroid Females
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2018-01-05
Enrollment: 180
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: the effect using low dose levo thyroxine in pregnant females with TSH level more than 2.5 mU/L in the first trimester on pregnancy outcome

Detailed description: the study aim to detect the effect of low dose levothyroxine 50 ug on pregnant females and compare it with others receiving placebo

Eligibility criteria: Inclusion Criteria:

* females with TSH more than 2.5 mU/L and less than 4 mU/L after biochemical diagnosis of pregnancy.

Exclusion Criteria:

* associated endocrinopathies (PCO/ DM/ hyperprolactinemia )
* associated medical condition (HTN/ chronic kidney disease.
* history of recurrent pregnancy loss

Primary outcomes:
measure: 1st trimester miscarriage
timeFrame: during 1st 13 weeks of pregnancy
Secondary outcomes:
measure: adverse pregnancy outcome
timeFrame: last 26 week of gestation
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: AinShams university maternity hospital
state: Abbassya
Study officials:
References:
Clinical trial NCT03976154: Effects of Fixation Technique On Thoracic Epidural Catheter Displacement
Official title: The Effects of Fixation Technique On Thoracic Epidural Catheter Displacement: A Single-Center Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Thoracic Epidural
Lead sponsor: University of Utah
Sponsor class: OTHER
First posted: 2019-06-05
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of our study is to assess the effectiveness of Dermabond as a thoracic epidural fixation technique compared to both Mastisol and the Grip-Lok fixation bandage, two common, widely used techniques for epidural fixation.


Eligibility criteria: Inclusion Criteria:

* surgical patient
* receiving a thoracic epidural
* 18 years of age or older

Exclusion Criteria:

* Patient refusal
* allergy to adhesives or local anesthesia
* pregnancy
* contraindication to receiving an epidural including coagulopathy, infection, elevated ICP, or severe pre-existing neurologic disorders

Primary outcomes:
measure: Epidural catheter displacement immediately after surgery
timeFrame: immediately after surgery in PACU
measure: Epidural catheter displacement day 1
timeFrame: 24 hours post-operative
measure: Epidural catheter displacement day 2
timeFrame: 48 hours post-operative
measure: Epidural catheter displacement day 3
timeFrame: 72 hours post-operative
measure: Epidural catheter displacement day 4
timeFrame: 96 hours post-operative
measure: Epidural catheter displacement day 5
timeFrame: 120 hours post-operative
measure: Epidural catheter displacement day 6
timeFrame: 144 hours post-operative
measure: Epidural catheter displacement day 7
timeFrame: 168 hours post-operative
Secondary outcomes:
measure: Leakage
timeFrame: immediately after surgery in PACU and daily until the patient is discharged up to post-operative day 7
measure: Percent of patients with skin changes as measured by clinician subjective assessment
timeFrame: immediately after surgery in PACU and daily until the patient is discharged up to post-operative day 7
measure: Opioid consumption
timeFrame: daily up to 7 days post-operative
Other outcomes:
Locations:
city: Salt Lake City
country: United States
facility: University of Utah Health Sciences Center
state: Utah
Study officials:
References:
Clinical trial NCT02425254: Preemptive Paracetamol for Postoperative Pain
Official title: Preemptive Paracetamol for Postoperative Pain: a Randomised, Double-blind, Two Way Crossover Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Pain
Surgical Wound
Lead sponsor: University of Nottingham
Sponsor class: OTHER
First posted: 2015-04-23
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to test whether a dose of paracetamol given before surgical incision is more effective at reducing postoperative pain and analgesic consumption in cervical spine surgery versus a dose given at the end of surgery.


Eligibility criteria: Inclusion Criteria:

* Aged 18-80 years old
* Patients listed for non-malignant cervical spinal surgery
* General anaesthesia
* Capacity to give informed consent
* Ability to use PCA device and pain score scale
* ASA I, II and III
* \>50kg in weight

Exclusion Criteria:

* Allergy or sensitivity to paracetamol, proparacetamol or morphine
* Liver disease
* Renal disease (creatinine clearance \<30ml/min)
* Bleeding disorder
* Chronic alcoholism
* Chronic malnutrition
* Dehydration
* G6PD deficiency
* Hypernatraemia (Na \>150)
* Hypokalaemia (K \<3.5) and hyperchloraemia
* Pregnancy or breast-feeding

Primary outcomes:
measure: Morphine consumption
timeFrame: 24 hours postoperatively
Secondary outcomes:
measure: Time to first analgesic request
timeFrame: 24 hours
measure: Nausea and vomiting
timeFrame: 24 hours
measure: Pruritus
timeFrame: 24 hours
measure: Sedation
timeFrame: 24 hours
measure: Urinary retention
timeFrame: 24 hours
measure: Allergic reaction
timeFrame: 24 hours
measure: Pain score
timeFrame: 1 hour
measure: Pain score
timeFrame: 2 hours
measure: Pain score
timeFrame: 6 hours
measure: Pain score
timeFrame: 12 hours
measure: Pain score
timeFrame: 24 hours
Other outcomes:
Locations:
Study officials:
affiliation: University of Nottiongham
name: John Williams
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06275854: YASU Research Registry: for Young Adults with Cancer
Official title: Young Adult Survivors United Cancer Research Registry
Study type: OBSERVATIONAL
Overall status: ENROLLING_BY_INVITATION
Conditions: Cancer
Leukemia
Sarcoma
Germ Cell Cancer
Lymphoma
Colorectal Cancer
Melanoma
Breast Cancer
Keywords: young adult cancer
Lead sponsor: Young Adult Survivors United
Sponsor class: OTHER
Collaborators: name: Staunton Farm Foundation
name: Elsie H. Hillman Foundation
First posted: 2024-02-23
Enrollment: 5000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Any young adult diagnosed with cancer between the ages of 18 and 39 willing to register on the YASU website and consents to participation in the research registry.

Brief summary: The goal of this observational research registry is to learn about health, wellbeing, and needs of survivors of young adult cancer (diagnosed between the ages of 18 and 39). The main question\[s\] it aims to understand are:

* What are the levels of depression, anxiety, social support, and financial distress
* Determine effectiveness of YASU programming by measuring changes over time

With this registry, the investigators also plan to identify survivors who may be eligible for participation in future research studies pertaining to young adult cancer.

Participants will be asked to complete electronic surveys every 6 to 12 months during participation in the registry.

Detailed description: The study will be conducted online.

Eligibility criteria: Inclusion Criteria:

1. Cancer diagnosis received between the ages of 18 and 39.
2. Able to speak and read English

Exclusion Criteria:

1. Inability to provide consent (such as neurological illness or mental incapacity)
2. Has not registered as a member of YASU

Primary outcomes:
measure: Anxiety
timeFrame: enrollment in registry, 6 months later, yearly until death
measure: Depressive symptoms
timeFrame: enrollment in registry, 6 months later, yearly until death
measure: Social Support
timeFrame: enrollment in registry, 6 months later, yearly until death
measure: Financial Toxicity
timeFrame: enrollment in registry, 6 months later, yearly until death
measure: Needs Assessment
timeFrame: enrollment in registry
Secondary outcomes:
measure: Name, address, email, phone number
timeFrame: enrollment in registry
Other outcomes:
Locations:
city: Wexford
country: United States
facility: Young Adult Survivors United
state: Pennsylvania
Study officials:
References:
Clinical trial NCT06325254: Clinical Characteristics of Metabolic Associated Fatty Liver Disease
Official title: A Multicenter, Retrospective Clinical Study on the Clinical Characteristics of Metabolic Associated Fatty Liver Disease
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Metabolic Associated Fatty Liver Disease
Clinical Features
Keywords: Metabolic associated fatty liver disease
Clinical features
Lead sponsor: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Sponsor class: OTHER
First posted: 2024-03-22
Enrollment: 3000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: MAFLD patients

Brief summary: Metabolic associated fatty liver disease (MAFLD), which can lead to liver fibrosis, cirrhosis, liver failure and even hepatocellular carcinoma, poses a significant burden on society. With the improvement of living standards and changes in dietary habits, MAFLD patients show a younger and increasing trend, but there is still no specific drug. The clinical features and prognosis of MAFLD may be different with different metabolic disorder phenotypes and treatment measures. Therefore, further systematic study of the clinical characteristics and prognosis of MAFLD patients will be of great significance for the formulation of corresponding clinical prevention and treatment strategies.

Detailed description: Metabolic associated fatty liver disease (MAFLD), which can lead to liver fibrosis, cirrhosis, liver failure and even hepatocellular carcinoma, poses a significant burden on society. With the improvement of living standards and changes in dietary habits, MAFLD patients show a younger and increasing trend, but there is still no specific drug. The clinical features and prognosis of MAFLD may be different with different metabolic disorder phenotypes and treatment measures. Therefore, further systematic study of the clinical characteristics and prognosis of MAFLD patients will be of great significance for the formulation of corresponding clinical prevention and treatment strategies.

Eligibility criteria: Inclusion Criteria:

1. 18 years or older;
2. MAFLD patients

Exclusion Criteria:

1. malignant tumors;
2. mental illness, severe impairment of cardiopulmonary function, severe renal insufficiency, severe infections, and cerebrovascular accidents;
3. received liver or other organ transplants.

Primary outcomes:
measure: Clinical characteristics and follow-up outcomes of MAFLD patients
timeFrame: 480 weeks
Secondary outcomes:
measure: Clinical characteristics and follow-up outcomes of MAFLD patients under different subgroups
timeFrame: 480 weeks
measure: Baseline clinical characteristics MAFLD patients
timeFrame: 0 weeks
measure: Risk factors for progression to cirrhosis and hepatocellular carcinoma
timeFrame: 480 weeks
Other outcomes:
Locations:
city: Nanjing
country: China
facility: Nanjing Drum Tower Hospital
state: Jiangsu
Study officials:
References:
Clinical trial NCT01268254: Red Wine and Ageing and Atherosclerosis
Official title: The Red Wine Project: a Study of Ageing Indexes and Prevalence of Atherosclerosis in Regular Red Wine Consumers Versus Abstainers
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Coronary Disease
Keywords: wine
aging
atherosclerosis
telomere
tomography
coronary vessels
Lead sponsor: University of Sao Paulo
Sponsor class: OTHER
First posted: 2010-12-29
Enrollment: 200
Sex: MALE
Minimum age (years): 50
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: male subjects, between 50 years-old and 70 years-old, divided in 2 groups: usual red wine consumers and red wine abstemious

Brief summary: The investigators will evaluate 100 regular red wine consumer men and 100 abstainers men from 50 years-old to 70 years-old by coronary risk prevalence, mood status, anthropometric measures, daily caloric ingest, lipid profile, carotid intimal media thickness, brachial flow mediate dilatation, coronary tomographic angiography and leucocyte telomere length.

The sample size has been calculated expecting that regular red wine ingestion would lead to a five year old younger vascular ageing indexes measured by carotid intimal media thickness, coronary artery calcium scores and leucocyte telomere length longer than those abstainers subjects at same age.

The investigators hypothesized that regular wine consumers present less coronary lesion and coronary calcium score on coronary tomographic angiography, lower carotid intimal media thickness and higher mean telomere length due the benefice of wine.


Eligibility criteria: Inclusion Criteria:

* healthy male, from 50 years-old to 70 years-old.

Exclusion Criteria:

* asiatic or with manifest atherosclerosis disease

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Sao Paulo
country: Brazil
facility: Heart Insitute ( InCor) University of Sao Paulo
Study officials:
affiliation: University of Sao Paulo
name: Protasio L Da Luz, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04822454: Early Exposure of Medical Students to Night Shifts: Impact on Well-being and Anxiety
Official title: Early Exposure of Medical Students to Night Shifts: Impact on Well-being and Anxiety
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Medical Students Well-being and Anxiety
Lead sponsor: St Joseph University, Beirut, Lebanon
Sponsor class: OTHER
First posted: 2021-03-30
Enrollment: 70
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: This is an interventional study assessing the impact of 'shadowing night shifts' early during medical school, on the wellbeing and level of anxiety of a students during their first official night shifts.


Eligibility criteria: Inclusion Criteria:

* Students of the class of 2021 at the Faculty of Medicine of Saint Joseph University in their fifth year (Med 2).

Exclusion Criteria:

* student who has already been on call during internships in Lebanon or abroad, as well as students in other medical years.

Primary outcomes:
measure: Questionnaire
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Beyrouth
country: Lebanon
facility: Saint Joseph University
state: N/A (n/a)
Study officials:
References: