louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05708209: The Long Non Coding MALAT1 as a Potential Salivary Diagnostic Biomarker in Oral Squamous Cell Carcinoma Through Targeting mi RNA 124
Official title: The Long Non Coding MALAT1 as a Potential Salivary Diagnostic Biomarker in Oral Squamous Cell Carcinoma Through Targeting mi RNA 124
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Oral Squamous Cell Carcinoma
Keywords: Long non coding RNA, Oral squamous cell carcinoma, Micro RNA, Salivary biomarkers, MALAT1, Oral cancer biomarkers
Lead sponsor: Fayoum University
Sponsor class: OTHER
First posted: 2023-02-01
Enrollment: 40
Sex: ALL
Minimum age (years): 20
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Observational model: OTHER
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with diagnosis of oral squamous cell carcinoma

Brief summary: Objective: is to determine the diagnostic accuracy of lncRNA MALAT1 as a potential salivary biomarker of OSCC as well as assessment of the salivary expression level of miRNA 124 which is targeted by MALAT1. Materials and Methods: Saliva Samples were collected for the quantitative determination of salivary "MALAT1 and mi RNA -124" using quantitative Real-time Polymerase Chain Reaction technique for the two study groups, Group A: 20 patients with a diagnosis suggestive of OSCC and Group B: 20 age-and-sex-matched healthy individuals, as normal controls.

Detailed description: Materials and Methods: Saliva Samples were collected for the quantitative determination of salivary "MALAT1 and mi RNA -124" using quantitative Real-time Polymerase Chain Reaction technique for the two study groups, Group A: 20 patients with a diagnosis suggestive of OSCC and Group B: 20 age-and-sex-matched healthy individuals, as normal controls.

Eligibility criteria: Inclusion Criteria:

* The study included patients with OSCC and healthy controls of both sexes.

Exclusion Criteria:

* Patients having systemic diseases such as; liver diseases, cardiovascular disease, nervous system, pulmonary, renal, endocrine, gastrointestinal disorders, or other types of cancer were excluded.

Primary outcomes:
measure: quantitative determination of salivary non-coding RNAs "MALAT1
timeFrame: 2 months
Secondary outcomes:
measure: quantitative determination of salivary mi RNA -124"
timeFrame: 2 months
Other outcomes:
Locations:
city: Giza
country: Egypt
facility: Rania Hassan Shalby
Study officials:
References:
Clinical trial NCT04224909: Video HIT in Sudden Sensorineural Hearing Loss
Official title: Video HIT Results in Sudden Sensorineural Hearing Loss Patients
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Sudden Sensorineural Hearing Loss
Lead sponsor: Tel-Aviv Sourasky Medical Center
Sponsor class: OTHER_GOV
First posted: 2020-01-13
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients diagnosed with Sudden Sensorineural Hearing Loss

Brief summary: The function of the vestibular system among patients with Sudden Sensori Neural Hearing Loss will be evaluted using the video Head Impulse Test


Eligibility criteria: Inclusion Criteria:

* Patients hospitalized with the diagnosis of Sudden Sensorineural Hearing Loss

Exclusion Criteria:

* Vertigo
* Other etiology causing dizziness
* Neurological dysfunction othe than the hearing loss
* Difficulty performing the vHIT
* Chronic vestibular disorder
* Pregnant women

Primary outcomes:
measure: The gain of each canal, as calculated using the vHIT
timeFrame: 15 minutes
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04048109: The Point of View of Adolescents Who Have Undergone a Suicidal Act: What Do They Expect from Their Relationship with Their Doctor?
Official title: The Point of View of Adolescents Who Have Undergone a Suicidal Act: What Do They Expect from Their Relationship with Their Doctor?
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Suicidal Act
Lead sponsor: Centre Hospitalier Universitaire de Nīmes
Sponsor class: OTHER
First posted: 2019-08-07
Enrollment: 10
Sex: ALL
Minimum age (years): 12
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adolescents aged 12 to 18 years with suicidal act

Brief summary: Evaluate the expectations of adolescents who have performed a suicidal act with regard to their relationship with their doctor


Eligibility criteria: Inclusion Criteria:

* Adolescents who have undergone a suicidal act and who were initially treated by the paediatric emergency department of the University Hospital of Nîmes.
* Teenagers with an attending physician.
* Adolescents who do not object to participating in the study
* Parents (holder of parental authority) who do not object to their child participating in the study
* Preliminary agreement to participate in the research project of the child psychiatrist treating the child.

Exclusion Criteria:

* - Patient who has objected to the use of his data.
* Refusal by the child psychiatrist to participate in the study.

Primary outcomes:
measure: percentage of adolescents with poor relationship with the doctor
timeFrame: 2019
Secondary outcomes:
Other outcomes:
Locations:
city: Nîmes
country: France
facility: CHU Nimes
Study officials:
References:
Clinical trial NCT01933009: The Effect of GnRH Administration During Luteal Support in Frozen-thawed Transfer Cycles
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Pregnancy Rate
Lead sponsor: Assaf-Harofeh Medical Center
Sponsor class: OTHER_GOV
First posted: 2013-08-30
Enrollment: 100
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Women undergoing frozen-thawed IVF cycles

Brief summary: GnRH administration during the luteal phase was found to significantly increase pregnancy rates in women undergoing fresh-cycle IVF cycles.

We aim to investigate the effect of GnRH administration during the luteal phase in women undergoing frozen-thawed IVF cycles.


Eligibility criteria: Inclusion Criteria:

Frozen-thawed IVF cycles

Exclusion Criteria:

Hydrosalpings Uterine myomas

Primary outcomes:
measure: Pregnancy rate
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Zerifin
country: Israel
facility: IVF and infertility unit, Assaf Harofeh Medical Center
state: Be'er-Ya'akov
Study officials:
References:
Clinical trial NCT04195009: Impact of Suppressing Surgical Stress Reaction on Postoperative Inflammation.
Official title: Observational Study Evaluating the Impact of Surgical Stress Suppression During Opioid Free Anesthesia on Postoperative Inflammation During Major Surgery.
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Inflammation
Postoperative Pain
Lead sponsor: AZ Sint-Jan AV
Sponsor class: OTHER
First posted: 2019-12-11
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: major surgical procedures without need for regional anesthesia

Brief summary: Patients undergoing surgery under opioid free general anesthesia (OFA) are monitored with antinociceptive devices like NOL or ANI that measures sympathetic activity but are invisible for the attending anesthesiologist . Observational study comparing patients with sufficient suppression of sympathetic reactions with patients having insufficient suppression on hemodynamic stability, post operative sedation, pain and inflammatory markers.

Detailed description: all patients get an opioid free anesthesia using dexmedetomidine, lidocaine, ketamine and magnesium. dosing is according to the attending anesthesiologist.

total dose of each drug and duration of anesthesia are recorded. Antinociceptive devices measures how long the patient is during anesthesia having a nociceptive level nociception level index (NOL) or Analgesia Nociception Index (ANI) above normal without showing the data to the attending anesthesiologist.

Relationship is calculated between on one side the hemodynamic stability, postoperative sedation, pain, postoperative CRP and on the other side the time NOL is above 20 or ANI is below 50.

Eligibility criteria: Inclusion Criteria:

* major surgical procedures without need for regional anesthesia

Exclusion Criteria:

* allergy to one of the anesthetics used
* major liver, renal cardiac or pulmonary disease reducing normal function

Primary outcomes:
measure: CRP 24 hours postoperative
timeFrame: 24 hours postoperative
Secondary outcomes:
measure: hemodynamic stability
timeFrame: intraoperative
measure: postoperative pain using VAS score
timeFrame: up to 4 hours postoperative during post anesthetic care unit (PACU) stay
measure: postoperative sedation using Ramsay score
timeFrame: first 4 hours postoperative during PACU stay
measure: postoperative opioids used
timeFrame: first 24 hours postoperative
Other outcomes:
Locations:
city: Brugge
country: Belgium
facility: Azsintjan
Study officials:
affiliation: AZ Sint-Jan AV
name: Jan Paul Mulier, MD PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06233409: A Novel Sandwich Technique of Minimally Invasive Keratoplasty for Corneal Perforation
Official title: A Novel Sandwich Technique of Minimally Invasive Keratoplasty for Corneal Perforation
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Corneal Perforation, Corneal Stromal Lenticule,Sandwich Technique
Keywords: Corneal perforation, Corneal stromal lenticule,Sandwich technique
Lead sponsor: Tianjin Eye Hospital
Sponsor class: OTHER
First posted: 2024-01-31
Enrollment: 30
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients premedicated for keratoplasty surgery

Brief summary: The goal of this type of study to describe a new sandwich technique of minimally invasive keratoplasty (STMIK) by using SMILE-extracted lenticules for treatment corneal perforation and effectiveness.

The main question\[s\] it aims to answer are: 1.Corneal perforations require urgent attendances for prompt treatments. How can we restore the integrity of the eyeball as soon as possible, reduce complications, and restore vision in the case of lack of corneal material according to the conditions that may be obtained.

2.In China, nearly 1 million lenticules are obtained through all-femtosecond surgery every year. How to reuse and turn waste into precious materials for clinical application is an important study.

Participants will understand and signed the informed consent to take this new method for the treatment of their corneal perforations disease, which will obtain good results, but there may be a certain risk of complications.The main tasks participants will be asked to cooperate as required.The clinical eye check includes the test of includes visual acuity, slit lamp, anterior segment phase, anterior segment OCT and IOP.


Eligibility criteria: Inclusion Criteria:

1. Patients with corneal perforation who are willing to undergo treatment with this new technique;
2. The size of cornea perforation was ≦ 3mm

Exclusion Criteria:

1. The size of cornea perforation was \&gt;3mm
2. Patients with corneal perforation who were unwilling to be treated with this new technique.
3. Patients who could not be followed up regularly.

Primary outcomes:
measure: A Novel Sandwich Technique for Corneal Perforation
timeFrame: one year
Secondary outcomes:
Other outcomes:
Locations:
city: Tianjin
country: China
facility: Tianjin Eye Hospital
state: Tianjin
Study officials:
References:
Clinical trial NCT06909409: D Vitamin and Alveolar Macrophages in Idiopathic Pulmonal Fibrosis
Official title: D Vitamin and Alveolar Macrophages in Idiopathic Pulmonal Fibrosis
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Idiopathic Pulmonary Fibrosis (IPF)
Keywords: Idiopathic pulmonary fibrosis
pulmonary macrophages
alveolar macrophages
vitamin D
Soluble CD163
Soluble CD206
Lead sponsor: University of Aarhus
Sponsor class: OTHER
First posted: 2025-04-03
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients at the Department of Respiratory Diseases and Allergy, Aarhus University Hospital, Denmark, diagnosed with ILD or lung cancer.

Brief summary: The goal of this observational study is to gain deeper insights into human macrophages and vitamin D, and their interplay, within Idiopathic Pulmonary Fibrosis (IPF).

The overall questions, it aims to answer, are the following:

Do IPF patients suffer from systemic and local (pulmonary) insufficient levels of vitamin D? Do IPF patients suffer from pro-fibrotic and pro-inflammatory pulmonary macrophages?


Eligibility criteria: Inclusion Criteria:

* A clinical diagnosis of IPF, non-IPF ILD or lung cancer
* A signed informed consent

Exclusion Criteria:

* Do not speak Danish/Do not understand Danish

Primary outcomes:
measure: Vitamin D status
timeFrame: At enrollment
measure: Pulmonary macrophages
timeFrame: At enrollment
Secondary outcomes:
measure: Biomarker levels in blood and BAL samples
timeFrame: At enrollment
Other outcomes:
Locations:
city: Aarhus N
country: Denmark
facility: Aarhus University Hospital, Denmark
Study officials:
References:
Clinical trial NCT05812209: Stellate Ganglion Block to Treat Long COVID 19 Case Series
Official title: Stellate Ganglion Block to Treat Long COVID-19 Syndrome, A 41 Patient Retrospective Cohort Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Long COVID
Long Covid19
Post-COVID-19 Syndrome
Post Acute COVID-19 Syndrome
Dysautonomia
Anosmia
Dysgeusia
Brain Fog
Muscle Pain
Shortness of Breath
Dizziness
Fatigue Post Viral
Cough
Menstrual Cycle Abnormal
Pain
Lead sponsor: Metamorphosis LTD
Sponsor class: OTHER
First posted: 2023-04-13
Enrollment: 41
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The study included 18 male and 23 females with an age range between 18 and 89 who underwent stellate ganglion block (SGB) for long COVID-19 Syndrome.

Brief summary: An assessment of the effectiveness of Stellate Ganglion Block in alleviating symptoms of Long COVID-19.

Detailed description: We evaluated the treatment results of 41 patients (18 male and 23 female) aged between 18 and 89, who received Stellate Ganglion Block (SGB) with Ultrasound guidance for Long COVID-19 Syndrome. The patients were from the United States and received treatment at our Colorado clinics during the period of September to December 2022.Those who responded to our post-procedure follow-up calls were included in the study population.

Eligibility criteria: Inclusion Criteria: People who scheduled themselves for a SGB in our clinics in Colorado.

-

Exclusion Criteria:

Stellate Ganglion Block Contraindications

-

Primary outcomes:
measure: Symptom Response
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Cañon City
country: United States
facility: Metamorphosis LTD
state: Colorado
Study officials:
affiliation: Metamorphosis LTD
name: Lisa Pearson, DNAP
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02251756: Performance of Different Application Regimens of ACTINICA® on Protection From UVR-induced Erythema After One Day of Sun Exposure in Fair-skinned Healthy Subjects.
Official title: Performance of Different Application Regimens of ACTINICA® on Protection From UVR-induced Erythema After One Day of Sun Exposure in Fair-skinned Healthy Subjects.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy Subjects, Male or Female, of 18-60 Years Old, With Phototype I, II or III, Not Pre-treated/Pre-protected Skin
Lead sponsor: Galderma R&D
Sponsor class: INDUSTRY
First posted: 2014-09-29
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Study objective To assess the performance of different application regimens of Actinica® on protection from UV rays-induced erythema throughout 1 day of sun exposure in fair-skinned healthy subjects (phototype I to III).

Study centers A total of 20 subjects will be enrolled in 1 site in France.

Methodology This will be a monocentre, randomised, controlled, investigator-blind, intra-individual comparative clinical investigation.

There will be a total of 6 visits for each subject. Each subject will participate for a period of maximum 35 days.

Study population Healthy subjects, male or female, at least 18-60 years old, with phototype I, II or III, not pre-treated/pre-protected skin, meeting specific inclusion/exclusion criteria.

The clinical investigation will be conducted in 2 parts.

Part 1 - SPF determination:

To determine the SPF of Actinica® with application of two different amounts (0.8 and 2 mg/cm2).

Part 2 - Sun exposure:

To assess the performance of the different application regimens of Actinica® on protection from UVR-induced erythema throughout 1 day of sun exposure.


Eligibility criteria: Inclusion Criteria:

1. Male or female, 18-60 years of age,
2. Subject with Phototype I, II or III,
3. Subject with individual typology angle (ITA) 28-70°,
4. Subject with healthy skin / not tanned on the back,

Exclusion Criteria:

1. Subject with obvious skin cancer forms within the test areas, 2. Subject with hairs on the treated area that might interfere with clinical investigation assessments, 3. Subjects who have performed sun bathing at least four months before enrolment, 10. History of sun allergy / Mallorca acne, active photo induced or photo aggravated disease, or abnormal response to the sun (e.g., photosensitive dermatoses, polymorphic light eruption, solar urticaria, systemic lupus erythematosus, or dermatomyositis).

11. The subject has received, applied or taken the forbidden treatments within the specified time frame prior to the Day 0 visit (list available on request)

Primary outcomes:
measure: erythema score
timeFrame: Part 2 -Day 1
Secondary outcomes:
Other outcomes:
Locations:
city: Nice
country: France
Study officials:
References:
Clinical trial NCT04738656: Effectiveness of the Mediterranean Diet on Weight Loss After Endoscopic Bariatric Treatmen
Official title: Mediterranean-style and Open Protein Diet Plans on Weight Loss in Patients With Obesity After Endoscopic Bariatric Treatment
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Obesity
Obesity, Morbid
Keywords: Endoscopic bariatric treatment
Excess weight loss
Excess body mass index
Mediterranean diet plan
Open protein diet plan
Lead sponsor: Universitat Politècnica de Catalunya
Sponsor class: OTHER
Collaborators: name: University of Barcelona
name: Clinica Dorsia
First posted: 2021-02-04
Enrollment: 78
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Primary care clinic. Patients of Dorsia Clinics Surgery and Aesthetic Medicine

Brief summary: All participants were weighed every week for 24 weeks, wearing light clothes to the nearest 0.1 kg, using a body composition analyzer. Height was determined during the first clinic evaluation using a fixed wall stadiometer to the nearest 0.1 cm, in standing position.

Intervention: Participants followed a liquid diet plan during the first week after the endoscopic bariatric procedure (Bioenterics Intragastric Balloon - BIB - or Primary Obesity Surgery Endoluminal - POSE -). Subsequently, subjects were randomly assigned either a Mediterranean-style or a protein diet plan. Energy intake was calculated according to the Spanish Consensus on Bariatric Endoscopy.

The hypothesis of this project is to analyze whether the Mediterranean-style diet is more effective compared with the open protein diet plans in weight loss and weight relapse in subjects with obesity who underwent endoscopic bariatric therapies.


Eligibility criteria: Inclusion Criteria:

* no previous gastric intervention
* no hiatus hernias
* not being pregnant or in breastfeeding
* not having cardiac problems, and having regular values in coagulation and blood count,
* having a positive psychological evaluation.

Exclusion Criteria:

* lack of compliance with the dietary treatment
* adverse effects of the surgery
* refuse to complete the treatment
* lack of adherence

Primary outcomes:
measure: Weekly weight loss
timeFrame: Every week up to 24 weeks
measure: Weight relapse after 36 weeks
timeFrame: 1 time after 36 weeks
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04686656: Nasal Versus Buccal Oxygen Administration for Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration
Official title: A Randomized Controlled Trial Comparing Nasal With Buccal Oxygen Administration for Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Lung Diseases
Lead sponsor: Antalya Training and Research Hospital
Sponsor class: OTHER_GOV
First posted: 2020-12-29
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The purpose of this study is to compare to nasal and buccal oxygen administration in patients undergoing Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration .

Detailed description: Anesthesia for Endobronchial Ultrasound (EBUS) may be range from routine bronchoscopy sedation to general anesthesia. During sedation to EBUS increased duration of anesthesia and sedative dosing put patients at increased risk for hypoxic events. To avoid this, oxygen supplementation is mandatory. There are different techniques for oxygen supplementation during the procedure. At this study we will compare to nasal and buccal oxygen supplementations during EBUS.

Eligibility criteria: Inclusion Criteria:

* patients ≥18 years of age
* body mass index (BMI) between 20 and 30
* American Society of Anesthesiologists physical status I-III

Exclusion Criteria:

* congestive heart failure
* ischemic heart disease
* increased intracranial pressure
* known allergy or contraindication to study drugs (propofol, fentanyl, or midazolam)
* an anatomical feature precluding adequate positioning of the buccal device.

Primary outcomes:
measure: hypoxia-related interruptions
timeFrame: 30 minutes
Secondary outcomes:
measure: duration of procedure
timeFrame: 30 minutes
measure: use of propofol
timeFrame: 30 minutes
measure: use of fentanyl
timeFrame: 30 minutes
measure: satisfaction of pulmonary specialist
timeFrame: 30 minutes
Other outcomes:
Locations:
city: Antalya
country: Turkey
facility: Antalya Training and Researching Hospital
Study officials:
affiliation: Antalya Training and Research Hospital
name: tayfun sugur, MD
role: PRINCIPAL_INVESTIGATOR
References: