louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04774861: Correlation of Cardiac Computed Tomography Angiography Dimensions and Ethnicity in Trinidad
Official title: Correlation of Cardiac Computed Tomography Angiography Dimensions and Ethnicity in Trinidad: The CADET Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Coronary Artery Disease
Lead sponsor: The University of The West Indies
Sponsor class: OTHER
First posted: 2021-03-01
Enrollment: 170
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Any patient who underwent CCTA from 2017-2020 at the Eric Williams Medical Sciences Complex.

Brief summary: The aim of this study is to compare coronary artery dimensions on Cardiac CT angiography amongst different ethnicities in Trinidad.

Detailed description: The aim of this study is to compare coronary artery dimensions on Cardiac CT angiography amongst different ethnicities in Trinidad.

Eligibility criteria: Inclusion Criteria:

1. CCTA for chest pain
2. All ethnicities
3. All genders

Exclusion Criteria:

1. Patients who did not provide consent.

Primary outcomes:
measure: Coronary Artery Dimension
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Saint Augustine
country: Trinidad and Tobago
facility: The University of the West Indies
state: North
Study officials:
References:
citation: Welch T, Rampersad F, Motilal S, Seecheran NA. Comparison of cardiac CT angiography coronary artery dimensions and ethnicity in Trinidad: the CADET pilot study. Open Heart. 2022 Mar;9(1):e001922. doi: 10.1136/openhrt-2021-001922.
Clinical trial NCT01801761: A Simplified Questionnaire to Detect OSA in COPD Patients
Official title: A Simplified Screening Questionnaire to Detect the Existence of Severe Obstructive Sleep Apnea in Chronic Obstructive Pulmonary Disease Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: OSA
COPD
Lead sponsor: Chang Gung Memorial Hospital
Sponsor class: OTHER
First posted: 2013-03-01
Enrollment: 67
Sex: ALL
Minimum age (years): 40
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: develop group : previous COPD cohort study validation group : consecutive COPD patient from outpatients clinics

Brief summary: To detect the existence of severe obstructive sleep apnea (OSA) in chronic obstructive pulmonary disease (COPD) patients, which had higher mortality and hospitalization rate, a simplified questionnaire was developed for identifying those COPD patients with severe OSA.

Detailed description: To detect the existence of severe obstructive sleep apnea (OSA) in chronic obstructive pulmonary disease (COPD) patients, which had higher mortality and hospitalization rate, a simplified questionnaire was developed for identifying those COPD patients with severe OSA.

With patient's BMI, neck and waist circumference, snores, witnessed apnea...

Time frame suspect to enroll 5 patients in 1 month and complete 4 patients at least we need 24 months to complete 120 patients

Eligibility criteria: Inclusion Criteria:

* stable COPD patients

Exclusion Criteria:

* cancer exacerbation in recent 2 months pregnancy central type sleep apnea claustrophobia chronic respiratory failure

Primary outcomes:
measure: The efficacy of simple questionnaire to detect severe OSA in COPD patients
timeFrame: since Dec 1, 2012 to Dec 1, 2014 (up to 2 years)
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Department of Thoracic Medicine, Chang Gung Memorial Hospital
Study officials:
affiliation: Department of Thoracic Medicine, Chang Gung Memorial Hospital 199 Tun-Hwa N. Rd., Taipei, Taiwan
name: Tsai-Yu Wang, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05216861: Evaluation of a Collaborative Intervention to Promote Employer Contact and RTW Among People With CMD or Chronic Pain
Official title: Evaluation of a Collaborative Intervention to Promote Early Employer Contact and Return to Work Among People With Common Mental Disorders or Long-term Pain
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Pain, Chronic
Mental Disorder
Lead sponsor: Uppsala University
Sponsor class: OTHER
Collaborators: name: Uppsala University Hospital
First posted: 2022-02-01
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The overall aim of this cluster ranomized controlled trial is to investigate whether an intervention for collaboration between patient with CMD or chronic pain and employer (the Demand and Ability Protocol) can contribute to reduced sick leave and to increased health, work ability and trust in the managers. The intervention is delivered by rehabiliation coordinators at primary health care centres.

Detailed description: The overall aim of this cluster ranomized controlled trial is to investigate whether an intervention for collaboration between patient with CMD or chronic pain and employer (the Demand and Ability Protocol) can contribute to reduced sick leave and to increased health, work ability and trust in the managers. The intervention is delivered by rehabilitation coordinators at primary health care centres.

Furthermore, the aim is to identify hindering and facilitating factors for feasibility, usability and implementation of the Demand and Ability Protocol intervention (DAP) in primary health care.

Research questions:

1. What is the effect of DAP for patients regarding sick leave, health, work ability, and trust in the manager compared to matched controls who do not recieve DAP?
2. How do patients and managers experience their participation in the intervention and how do they experience the usability of the DAP?
3. What facilitating and hindering factors exist for the introduction and implementation of DAP in primary health care, and how do rehabilitation coordinators (REKO) and medical doctors experience the feasibility and usability of the intervention?

Eligibility criteria: Inclusion Criteria:

* have a diagnosis of CMD and/or chronic pain
* have a job
* be on full-time or part time sick leave
* accept the manager's involvement.

Exclusion Criteria:

* been on full-time sick leave for more than 6 months before the first contact with REKO

Primary outcomes:
measure: Sick leave
timeFrame: From baseline until 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Uppsala
country: Sweden
facility: Region Uppsala
state: Uppsala Lan
Study officials:
affiliation: Uppsala University
name: Therese Hellman, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02321761: Effect of Amantadine Administration on Spatial Functioning Following Traumatic Brain Injury
Official title: Effect of Amantadine Administration on Spatial Functioning Following Traumatic Brain Injury
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Traumatic Brain Injury
Keywords: Amantadine hydrochloride
Rehabilitation
Acquired Brain Injury
TBI
Lead sponsor: Loewenstein Hospital
Sponsor class: OTHER
First posted: 2014-12-22
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Amantadine hydrochloride is one of the drugs given at rehabilitation programs to people who suffered Acquired Brain Injury in order to expedite recovery and improve functioning.

A previous study examined the spatially asymmetric allocation of attention in patients with traumatic brain injury (TBI). Patients demonstrated significantly worse performance with leftward than with rightward cross-hemi field shifts of attention. This is reminiscence of neglect patients. This difference was significantly reduced during and following treatment. Our objective is to investigate whether Amantadine Hydrochloride is effective in improving allocation of spatial attention and improving function in people with Traumatic Brain Injury.


Eligibility criteria: Inclusion Criteria:

1. Aged 18-50 yrs
2. Patients who were diagnosed with a Diffuse Axonal Injury post TBI
3. Severity of injury was defined as moderate to severe
4. At least 3 months post injury
5. Sufficient cognitive abilities to learn and perform the computerised task.

Exclusion Criteria:

1. Pyramidal signs on neurological examination
2. Localised damage demonstrated on CT
3. Contra indication to Amantadine, post traumatic epilepsy, renal failure and patients with known sensitivity to Amantadine
4. Patients who were diagnosed with Parkinson's disease or has a first degree family who was diagnosed with Parkinson's.

Primary outcomes:
measure: The Posner Cueing Task
timeFrame: up to day 70
Secondary outcomes:
Other outcomes:
Locations:
city: Ra'anana
country: Israel
facility: Loewenstein Rehabilitation Center
Study officials:
References:
Clinical trial NCT01375361: Nebulized Albuterol for Congestive Heart Failure Exacerbation
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: PHASE2
PHASE3
Conditions: Congestive Heart Failure
Keywords: albuterol
Lead sponsor: University of California, San Francisco
Sponsor class: OTHER
First posted: 2011-06-17
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This is a randomized trial of the use of Albuterol in the setting of acute decompensated Congestive Heart Failure with radiographic evidence of Cardiogenic Pulmonary Edema.

Detailed description: The objective is to carry out a randomized blinded placebo-controlled trial of inhaled Albuterol as an early therapy for patients with decompensated Congestive Heart Failure. Compared to placebo, inhaled Albuterol will improve oxygenation and decrease the need for non-invasive ventilation in patients with Cardiogenic Pulmonary Edema.

Eligibility criteria: Inclusion Criteria:

* age 18-65 with shortness of breath and history of CHF
* pulmonary edema on chest xr

Exclusion Criteria:

* pregnancy
* clinical or ekg changes to suggest acute coronary syndrome
* history of copd or asthma
* history of albuterol on medication list

Primary outcomes:
measure: Borg Dyspnea Score
timeFrame: 8 hours.
Secondary outcomes:
measure: Admission
timeFrame: An average of 48 hours
Other outcomes:
Locations:
city: San Francisco
country: United States
facility: University of California
state: California
Study officials:
affiliation: University of California, San Francisco
name: John C. Stein, MD.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01025661: Effects of Chiropractic Care in Patients With Hip Osteoarthritis
Official title: Effects of Chiropractic Care on Pain and Function in Patients With Hip Osteoarthritis Waiting for Arthroplasty - a Controlled Clinical Pilot Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hip Osteoarthritis
Keywords: chiropractic
hip osteoarthritis
hip arthroplasty
pain
activities of daily living.
Lead sponsor: Scandinavian College of Chiropractic
Sponsor class: OTHER
Collaborators: name: Karolinska Institutet
name: Stockholm South General Hospital
First posted: 2009-12-03
Enrollment: 14
Sex: ALL
Minimum age (years): 55
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of the study is to explore the short term effects of chiropractic care on pain and function in patients with hip osteoarthritis.

Detailed description: Research over the last years have reported a scarce of trails investigating chiropractic treatment of lower extremities. Osteoarthritis, also called joint failure, is a common rheumatic joint disease often affecting the hipjoint, contributing to pain, decreased mobility and loss of function. Individuals with osteoarthritis can also be affected in many other ways, e.g. economically, socially and emotionally.

Chiropractic care may be considered as a complement to the conventional allopathic treatment of hip osteoarthritis. Joint manipulation is a well-established treatment technique to restore optimal joint function of the locomotor system. The aim of the study is to explore the effects of chiropractic vs. continued conventional care (waiting list controls) on pain and function during a three week trail period among patients with hip osteoarthritis waiting for arthroplasty.

Eligibility criteria: Inclusion Criteria:

* waiting for first time unilateral arthroplasty on the affected side

Exclusion Criteria:

* documented osteoporosis, current pathology such as malignancy, infection, cardiovascular disease, stroke and femoral fractures on affected side

Primary outcomes:
measure: The 100mm Visual Analogue Scale (VAS)
timeFrame: Baseline and follow up after three weeks
Secondary outcomes:
measure: The five sub-scales of the Hip disability and Osteoarthritis Outcome Score (HOOS), i.e. pain, other symptoms, function in daily living (ADL), function in sport and recreation (sport/rec) and hip related Quality of life (QOL)
timeFrame: Baseline and follow up after three weeks
Other outcomes:
Locations:
city: Solna
country: Sweden
facility: Scandinavian College of Chiropractic
state: Stockholm
Study officials:
affiliation: Skandinavian College Of Chiropractic
name: P M Thorman et al, RC
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04369261: Observational Study of Synovian® Inj. in Patients With Osteoarthritis in the Knee
Official title: A Multicenter, Prospective Observational Study to Evaluate the Injection Site Reactions of Synovian® Inj. in Patients With Osteoarthritis in the Knee
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Osteoarthritis in the Knee
Lead sponsor: LG Chem
Sponsor class: INDUSTRY
First posted: 2020-04-30
Enrollment: 1949
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: A patient from hospital and clinic as well

Brief summary: This is an observational study to evaluate the injection site reactions of Synovian® Inj. in patients with osteoarthritis in the knee


Eligibility criteria: Inclusion Criteria:

* Adult male or female patient of over 19 years of age
* A patient diagnosed with knee osteoarthritis
* A patient who has been informed of the purpose, method of the study and signed the written informed consent form.

Exclusion Criteria:

* A patient who shows hypersensitive reaction to the Synovian® Inj. or to the ingredients of Synovian® Inj.
* A patient with infection at the joint
* A patient with skin infection or skin disease at the injection area
* A patient diagnosed with osteoarthritis with the Kellgren \& Lawrence Grade IV in X-ray within 12 months before enrollment of this study.

Primary outcomes:
measure: safety endpoints
timeFrame: Week 2
Secondary outcomes:
Other outcomes:
Locations:
city: Guri-si
country: Korea, Republic of
facility: Hanyang University GURI Hospital
state: Gyeonggi-do
Study officials:
References:
citation: Jang KM, Park YG, Choi WK, Chung YY, Kim KK, Lee JW, Lee SJ, Eom Y, Yang JH. Safety of a single intra-articular injection of LBSA0103 hyaluronic acid in patients with osteoarthritis of the knee: a multicenter, single-arm, prospective, cohort study. Curr Med Res Opin. 2021 Sep;37(9):1573-1580. doi: 10.1080/03007995.2021.1950132. Epub 2021 Jul 15.
Clinical trial NCT06613061: Effects of Breathing Exercises on Pain, Fatigue, and Anxiety Levels in Women Receiving Brachytherapy
Official title: Breathing Exercise Women Receiving Brachytherapy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Exercise
Keywords: radiothreapy
Lead sponsor: Amasya University
Sponsor class: OTHER
First posted: 2024-09-25
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: SUPPORTIVE_CARE

Brief summary: Breathing exercises are one of the most useful techniques to reduce stress and anxiety. The aim of this study is to determine the effects of breathing exercises on pain, anxiety and fatigue in patients receiving brachytherapy treatment.

Detailed description: Introduction: Breathing exercises are one of the most useful techniques to reduce stress and anxiety.

Objective: The aim of this study is to determine the effects of breathing exercises on pain, anxiety and fatigue in patients receiving brachytherapy treatment.

Method: The sample of the study will consist of 56 women who applied to the Brachytherapy Unit of a training and research hospital. The research data will be collected using the Introductory Information Form, Numerical Pain Scale, Beck Anxiety Inventory and Piper Fatigue Scale. Although studies have been conducted in different areas regarding breathing exercises, no study has been found in our country regarding the effects of breathing exercises on patients receiving brachytherapy. Therefore, this study will determine the effects of breathing exercises on pain, anxiety and fatigue in patients receiving brachytherapy treatment and contribute to the literature.

Conclusion: It is thought that breathing exercises will be beneficial in reducing physical and psychological symptoms.

Eligibility criteria: Inclusion Criteria:

* Being over 18 years old
* Being willing to participate in the study
* Being able to speak and understand Turkish

Exclusion Criteria:

* Having a malignancy related to the respiratory system (bronchus or lung)
* Having chest pain
* Having done box breathing and diaphragm breathing exercises/receiving training before
* Having cognitive dysfunction
* Not giving consent to participate in the study

Primary outcomes:
measure: Numerical pain scale
timeFrame: Two week
measure: Beck Anxiety Inventory
timeFrame: Two week
measure: Piper Fatigue Scale
timeFrame: Two week
Secondary outcomes:
Other outcomes:
Locations:
city: Amasya
country: Turkey
facility: Amasya University
Study officials:
References:
Clinical trial NCT04676061: Effects of a Progestin on Frequent and/or Prolonged Bleeding With Nexplanon™
Official title: Effects of a Progestin on Frequent and/or Prolonged Bleeding With Nexplanon™; a Randomized Double-Blinded Placebo-Controlled Trial
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE4
Conditions: Birth Control
Contraception
Implant
Breakthrough Bleeding
Uterine Bleeding
Keywords: Uterine Hemorrhage
Norethindrone Acetate
Contraceptives
Lead sponsor: Baylor Research Institute
Sponsor class: OTHER
Collaborators: name: Merck Sharp & Dohme LLC
First posted: 2020-12-19
Enrollment: 51
Sex: FEMALE
Minimum age (years): 14
Maximum age (years): 48
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: Effects of norethindrone acetate (NTA) in patients with Nexplanon.

Detailed description: The purpose of this study is to find out what effects norethindrone acetate (NTA) has on the duration and recurrence of frequent and/or prolonged bleeding associated with Nexplanon™.

Eligibility criteria: Inclusion Criteria:

* Between the ages of 18-48
* Between ages of 14-17 with parental/guardian permission
* Women desiring placement of Nexplanon™
* Willing to keep a daily symptom calendar
* Keep appointments
* Women not desiring to become pregnant in the next 2 years

Exclusion Criteria:

* Known or suspected Pregnancy
* Less than 8weeks postpartum
* Menarche less than two years ago
* Current or past history of thrombosis or thromboembolic disorders
* Hepatic tumors (benign or malignant)
* Active liver disease
* Undiagnosed abnormal genital bleeding
* Undiagnosed headaches
* Known or suspected carcinoma of the breast or personal history of breast cancer
* Hypersensitivity to any of the components in Nexplanon™
* BMI greater than 40
* Depomedroxyprogesterone acetate injection in the previous 12 weeks

Primary outcomes:
measure: Number of days of bleeding and spotting
timeFrame: 30 days
Secondary outcomes:
measure: Quality of life measurements
timeFrame: 30 days
Other outcomes:
Locations:
city: Temple
country: United States
facility: Baylor Research Institute
state: Texas
Study officials:
affiliation: Baylor Reserach Institute
name: Joanna Stacey, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03638661: n-3 Fatty Acids in Enteral Formula on NK Cell Activity
Official title: Effect of Immune-enhancing Enteral Nutrition Formula Enriched With Vegetable Derived n-3 Fatty Acids on NK Cell Activity in Hospitalized Patients for Rehabilitation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Enteral Nutrition
Lead sponsor: Yonsei University
Sponsor class: OTHER
First posted: 2018-08-20
Enrollment: 94
Sex: ALL
Minimum age (years): 19
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of our study was to investigate the NK cell activity alternations and related cytokine changes in comparison with soybean oil used formula (control) and the canola and flaxseed oil used n-3 fatty acid enriched formula (n3EN, test) with non-surgical hospitalized patients for rehabilitation.

Detailed description: Patients were randomized to receive one of two types of enteral nutrition formula: soybean oil used enteral nutrition (control), vegetable (canola, flaxseed) derived n-3 fatty acid enriched enteral nutrition (n3EN). Blood samples were collected on the first day and 14 days after consumption of each formula and anthropometric parameters were collected. Hematology and biochemical values were analyzed and NK cell activities and serum cytokine productions were measured.

Eligibility criteria: Inclusion Criteria:

* Patients who were admitted to the Severance Hospital Rehabilitation Department , enteral tube feeding patient, Adult male and female patients aged 19 years and over, Patients who signed the consent form

Exclusion Criteria:

* Patient with nausea
* Patients with hepatic impairment (total bilirubin concentration\> 3.5 mg / dl)
* Patients with renal impairment (serum creatinine concentration\> 3 mg / dl or requiring peritoneal or hemodialysis) diabetic patients
* Patients who are undergoing chemotherapy or who are within 1 month of the end of chemotherapy
* Patients whose life expectancy is less than 1 month
* Pregnant women and women who are pregnant

Primary outcomes:
measure: NK cell activity
timeFrame: Baseline
Secondary outcomes:
measure: cytokine values
timeFrame: Baseline
Other outcomes:
Locations:
Study officials:
References: