Clinical trial NCT03033511: A Study of Rovalpituzumab Tesirine as Maintenance Therapy Following First- Line Platinum-Based Chemotherapy in Participants With Extensive Stage Small Cell Lung Cancer (MERU)
Official title: A Randomized, Double-Blind, Placebo-Controlled Phase 3 Study of Rovalpituzumab Tesirine as Maintenance Therapy Following First-Line Platinum-Based Chemotherapy in Subjects With Extensive Stage Small Cell Lung Cancer (MERU)
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE3
Conditions: Small Cell Lung Cancer
Keywords: Extensive-Stage Small Cell Lung Cancer (ED SCLC)
Cancer
Platinum-Based Chemotherapy
Rovalpituzumab tesirine
first-line chemotherapy
Small Cell Lung Cancer (SCLC)
Delta-like protein 3 (DLL3)
Lead sponsor: AbbVie
Sponsor class: INDUSTRY
First posted: 2017-01-26
Enrollment: 748
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This is a Phase 3, randomized, double-blind, placebo-controlled, multinational, and multicenter study to evaluate the efficacy of rovalpituzumab tesirine as maintenance therapy following first-line platinum-based chemotherapy.


Eligibility criteria: Inclusion Criteria:

* Histologically or cytologically confirmed extensive-stage disease small cell lung cancer (ED SCLC) at initial diagnosis with ongoing clinical benefit (stable disease \[SD\], partial response \[PR\], or complete response \[CR\]) following completion of 4 cycles of first-line platinum-based therapy
* Participant is eligible to be randomized at least 3 but no more than 9 weeks from Day 1 of the fourth cycle of first-line platinum-based chemotherapy.
* Participants with a history of central nervous system (CNS) metastases prior to the initiation of first-line platinum-based chemotherapy must have received definitive local treatment and have documentation of stable or improved CNS disease status
* Eastern Cooperative Oncology Group (ECOG) performance score of 0 or 1
* Participants must have adequate bone marrow, renal and hepatic function
* Availability of archived or representative tumor material for assessment of DLL3 expression

Exclusion Criteria:

* Any prior systemic chemotherapy, small molecule inhibitors, immune checkpoint inhibitors, other monoclonal antibodies, antibody-drug conjugates, radioimmunoconjugates, T-cell or other cell-based or biologic therapies, or any other anti-cancer therapy than that described in inclusion criteria for SCLC.
* Any disease-directed radiotherapy (except prophylactic cranial irradiation, palliative radiotherapy to a radiographically documented non-progressing lesion for symptom control, or pre-planned radiotherapy for CNS metastases present prior to start of first-line therapy and non-progressing) after last dose of first-line chemotherapy.
* Prior exposure to a pyrrolobenzodiazepine (PBD-based) or indolinobenzodiazepine-based drug, prior participation in a rovalpituzumab tesirine clinical trial, or known hypersensitivity or other contraindications to rovalpituzumab tesirine or excipient contained in the drug formulation.

Primary outcomes:
measure: Overall Survival (OS) in Participants With Extensive-Stage Small Cell Lung Cancer With Delta-Like Protein 3 High Expression in Tumor (DLL3high)
timeFrame: Survival follow-up continued until the endpoint of death, participant was lost to follow-up or withdrew consent, or termination of the study by AbbVie, whichever occurred first. Median time on study overall was 11.9 months.
Secondary outcomes:
measure: OS in All Randomized Participants
timeFrame: Survival follow-up continued until the endpoint of death, the subject was lost to follow-up or withdrew consent, or termination of the study by AbbVie, whichever occurred first. Median time on study overall was 11.9 months.
measure: Change From Baseline in European Organization for Research and Treatment of Cancer Quality of Life Questionnaire Core (EORTC QLQ-C30) Physical Functioning Domain Over Time
timeFrame: Baseline, Weeks 6, 12, 18, 24, 30, 36, 42, 48, 54, 60, 66, 72, 78, Final Visit (up to Week 78)
Other outcomes:
Locations:
city: Huntsville
country: United States
facility: Clearview Cancer Institute /ID# 156699
state: Alabama
city: Mobile
country: United States
facility: University of South Alabama /ID# 160975
state: Alabama
city: Fayetteville
country: United States
facility: Highlands Oncology Group /ID# 156722
state: Arkansas
city: Greenbrae
country: United States
facility: Marin Cancer Care /ID# 159207
state: California
city: La Jolla
country: United States
facility: Ucsd /Id# 157764
state: California
city: Los Angeles
country: United States
facility: LA Hem-Oncology Med Group /ID# 156717
state: California
city: Palo Alto
country: United States
facility: Palo Alto Veterans Institute for Research /ID# 203695
state: California
city: Santa Rosa
country: United States
facility: St Jude Hospital dba St Joseph /ID# 156526
state: California
city: Whittier
country: United States
facility: Icri /Id# 157765
state: California
city: Lone Tree
country: United States
facility: Kaiser Permanente Lone Tree /ID# 159331
state: Colorado
city: Newark
country: United States
facility: Christiana Care Health Service /ID# 159212
state: Delaware
city: Fort Lauderdale
country: United States
facility: Holy Cross Hospital /ID# 156716
state: Florida
city: Gainesville
country: United States
facility: University of Florida - Archer /ID# 155799
state: Florida
city: Hollywood
country: United States
facility: Memorial Cancer Institute /ID# 156673
state: Florida
city: Hollywood
country: United States
facility: Memorial Cancer Institute /ID# 164052
state: Florida
city: Jacksonville
country: United States
facility: Cancer Specialists of North Florida - Southpoint /ID# 156595
state: Florida
city: Atlanta
country: United States
facility: Georgia Cancer Center /ID# 201894
state: Georgia
city: Newnan
country: United States
facility: Southeastern Regional Medical /ID# 163064
state: Georgia
city: Boise
country: United States
facility: St. Luke's Mountain States Tumor Institute - Boise /ID# 156691
state: Idaho
city: Evanston
country: United States
facility: NorthShore University HealthSystem - Evanston Hospital /ID# 156664
state: Illinois
city: Harvey
country: United States
facility: Ingalls Memorial Hosp /ID# 156685
state: Illinois
city: Goshen
country: United States
facility: Goshen Center for Cancer Care /ID# 156682
state: Indiana
city: Ashland
country: United States
facility: Ashland-Bellefonte Cancer Ctr /ID# 202901
state: Kentucky
city: Louisville
country: United States
facility: University of Louisville /ID# 156683
state: Kentucky
city: Baton Rouge
country: United States
facility: Ochsner Clinic Foundation /ID# 159136
state: Louisiana
city: Detroit
country: United States
facility: Henry Ford Health System /ID# 156712
state: Michigan
city: Lansing
country: United States
facility: Sparrow Regional Cancer Center, Sparrow Health System /ID# 156590
state: Michigan
city: Rochester
country: United States
facility: Mayo Clinic - Rochester /ID# 160181
state: Minnesota
city: Kansas City
country: United States
facility: MidAmerica Division, Inc. /ID# 163530
state: Missouri
city: Billings
country: United States
facility: Billings Clinic /ID# 201788
state: Montana
city: Lincoln
country: United States
facility: Nebraska Hematology Oncology /ID# 156534
state: Nebraska
city: Camden
country: United States
facility: MD Anderson Cancer Center at Cooper - Camden /ID# 156681
state: New Jersey
city: Bronx
country: United States
facility: Montefiore Medical Center /ID# 201845
state: New York
city: Lake Success
country: United States
facility: Northwell Health - Monter Cancer Center /ID# 159252
state: New York
city: New York
country: United States
facility: Icahn School of Med Mt. Sinai /ID# 159210
state: New York
city: Stony Brook
country: United States
facility: Stony Brook University Hospital /ID# 159272
state: New York
city: Durham
country: United States
facility: Duke University Medical Center /ID# 156706
state: North Carolina
city: Greensboro
country: United States
facility: Cone Health /ID# 156689
state: North Carolina
city: Greensboro
country: United States
facility: Cone Health /ID# 163612
state: North Carolina
city: Greenville
country: United States
facility: Eastern Carolina University /ID# 159264
state: North Carolina
city: Canton
country: United States
facility: Gabrail Cancer Center Research /ID# 156667
state: Ohio
city: Portland
country: United States
facility: Kaiser Permanente, NW /ID# 201793
state: Oregon
city: Philadelphia
country: United States
facility: Thomas Jefferson University /ID# 156719
state: Pennsylvania
city: Pittsburgh
country: United States
facility: VA Pittsburgh HealthcareSystem /ID# 159284
state: Pennsylvania
city: Providence
country: United States
facility: Rhode Island Hospital /ID# 160834
state: Rhode Island
city: Chattanooga
country: United States
facility: Sarah Cannon Research Institute-Chattanooga /ID# 202933
state: Tennessee
city: Knoxville
country: United States
facility: Thompson Cancer Survival Ctr /ID# 202460
state: Tennessee
city: Nashville
country: United States
facility: Tennessee Oncology-Nashville Centennial /ID# 161168
state: Tennessee
city: Austin
country: United States
facility: Univ Medical Ctr Brackenridge /ID# 155798
state: Texas
city: Dallas
country: United States
facility: Parkland Health and Hosp Syste /ID# 170933
state: Texas
city: Dallas
country: United States
facility: UT Southwestern Medical Center /ID# 157848
state: Texas
city: Houston
country: United States
facility: Houston Methodist Hospital - Scurlock Tower /ID# 202323
state: Texas
city: Spokane
country: United States
facility: Medical Oncology Associates /ID# 156715
state: Washington
city: Morgantown
country: United States
facility: West Virginia Univ School Med /ID# 156687
state: West Virginia
city: Coffs Harbour
country: Australia
facility: Coffs Harbour Hospital /ID# 158880
state: New South Wales
city: Gosford
country: Australia
facility: Gosford Hospital /ID# 158884
state: New South Wales
city: Lambton Heights
country: Australia
facility: Newcastle Private Hospital /ID# 203506
state: New South Wales
city: Saint Leonards
country: Australia
facility: Royal North Shore Hospital /ID# 158881
state: New South Wales
city: Adelaide
country: Australia
facility: Calvary North Adelaide Hospita /ID# 161701
state: South Australia
city: St Albans
country: Australia
facility: Sunshine Hospital /ID# 161700
state: Victoria
city: Nedlands
country: Australia
facility: Affinity Clinical Research Ser /ID# 158887
city: Vienna
country: Austria
facility: SMZ Baumgartner Höhe, Otto-Wagner-Spital und Pflegezentrum /ID# 201776
state: Wien
city: Vienna
country: Austria
facility: Krankenhaus Nord - Klinik Floridsdorf /ID# 201768
state: Wien
city: Graz
country: Austria
facility: LKH-Univ. Klinikum Graz /ID# 159563
city: Linz
country: Austria
facility: Ordensklinikum Linz GmbH, Elisabethinen /ID# 159564
city: Salzburg
country: Austria
facility: Salzburger Landeskliniken (SALK) /ID# 201779
city: Bobruisk
country: Belarus
facility: Bobruysk Interdistrict Onco. /ID# 169393
city: Lesnoy
country: Belarus
facility: State Institution Republican Scientific Practical Center of Oncology and Medica /ID# 159383
city: Mogilev
country: Belarus
facility: Mogilev Reg Clin Oncology Dis /ID# 159384
city: Bruxelles
country: Belgium
facility: CHU Saint-Pierre /ID# 159009
state: Bruxelles-Capitale
city: Charleroi
country: Belgium
facility: Grand Hôpital de Charleroi /ID# 159006
state: Hainaut
city: Antwerp
country: Belgium
facility: ZNA Middelheim /ID# 159007
city: Haine Saint Paul
country: Belgium
facility: Hopital de Jolimont /ID# 159005
city: Montigny-le-tilleul
country: Belgium
facility: CHU Charleroi (Vesale) /ID# 159008
city: Cachoeiro de Itapemirim
country: Brazil
facility: Hospital Evangelico de Cachoei /ID# 159657
state: Espirito Santo
city: Natal
country: Brazil
facility: Liga Norte Rio Grandense Cont. /ID# 159011
state: Rio Grande Do Norte
city: Ijuí
country: Brazil
facility: Associação Hospital de Caridade Ijuí - Centro de Tratamento de Cancer - CACON /ID# 159013
state: Rio Grande Do Sul
city: Passo Fundo
country: Brazil
facility: Associação Hospital Beneficente São Vicente de Paulo - Hospital São Vicente de P /ID# 159661
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Hospital Sao Lucas da PUCRS /ID# 159662
state: Rio Grande Do Sul
city: Barretos
country: Brazil
facility: Fundacao Pio XII - Hospital de Cancer de Barretos /ID# 159012
state: Sao Paulo
city: Sao Jose Do Rio Preto
country: Brazil
facility: Fundacao Faculdade Regional de Medicina de Sao Jose do Rio Preto /ID# 159659
state: Sao Paulo
city: Rio de Janeiro
country: Brazil
facility: Instituto Nacional de Câncer José de Alencar Gomes da Silva (INCA) /ID# 159658
city: Sofia
country: Bulgaria
facility: UMHAT Tsaritsa Joanna - ISUL /ID# 159638
city: Sofia
country: Bulgaria
facility: UMHAT Sv. Ivan Rilski /ID# 159639
city: Surrey
country: Canada
facility: British Columbia Cancer Agency /ID# 163721
state: British Columbia
city: Brampton
country: Canada
facility: Brampton Civic Hospital /ID# 204425
state: Ontario
city: Oshawa
country: Canada
facility: R.S. McLaughlin Durham Regional /ID# 170870
state: Ontario
city: Toronto
country: Canada
facility: Princess Margaret /ID# 170868
state: Ontario
city: Windsor
country: Canada
facility: Windsor Regional Cancer Centre /ID# 170869
state: Ontario
city: Québec
country: Canada
facility: Iucpq-Ul /Id# 159530
state: Quebec
city: Fuzhou
country: China
facility: Fujian Provincial Cancer Hospital /ID# 204864
state: Fujian
city: Harbin
country: China
facility: Harbin Medical University Cancer Hospital /Id# 203638
state: Heilongjiang
city: Wuhan
country: China
facility: Hubei Cancer Hospital /ID# 202886
state: Hubei
city: Changchun
country: China
facility: Jilin Cancer Hosptial /ID# 204060
state: Jilin
city: Urumqi
country: China
facility: The Affiliated Cancer Hospital of Xinjiang Medical university /ID# 203641
state: Xinjiang
city: Kunming
country: China
facility: Yunnan Cancer Hospital /ID# 204911
state: Yunnan
city: Hangzhou
country: China
facility: Zhejiang Cancer hospital /ID# 204640
state: Zhejiang
city: Jianggan Hangzhou
country: China
facility: Sir Run Run Shaw Hospital /ID# 206802
state: Zhejiang
city: Nanjing
country: China
facility: Jiangsu Province Hospital /ID# 205183
city: Xi'an
country: China
facility: 4th Military Medical Universit /ID# 203986
city: Xi'an
country: China
facility: First Affiliated Hospital of Xi'an Jiaotong University /ID# 203733
city: Zhengzhou Henan
country: China
facility: Henan Cancer Hospital /ID# 203983
city: Zhengzhou Henan
country: China
facility: Henan Cancer Hospital /ID# 204636
city: Zagreb
country: Croatia
facility: Klinicki bolnicki centar Sestre milosrdnice /ID# 159090
state: Grad Zagreb
city: Zagreb
country: Croatia
facility: Klinika za plucne bolesti Jordanovac /ID# 159505
state: Grad Zagreb
city: Rijeka
country: Croatia
facility: Klinicki bolnicki centar Rijeka /ID# 159504
state: Primorsko-goranska Zupanija
city: Prague
country: Czechia
facility: Thomayerova nemocnice /ID# 159062
state: Praha 4
city: Benesov
country: Czechia
facility: Nemocnice Rudolfa a Stefanie /ID# 159655
city: Horovice
country: Czechia
facility: Nemocnice Horovice a.s. /ID# 161186
city: Ostrava
country: Czechia
facility: Vitkovicka nemocnice a. s. /ID# 161187
city: Plzen
country: Czechia
facility: FN Plzen /ID# 204097
city: Pribram
country: Czechia
facility: Oblastni Nemocnice Pribram /ID# 159654
city: Copenhagen Ø
country: Denmark
facility: Rigshospitalet /ID# 158055
state: Hovedstaden
city: Herlev
country: Denmark
facility: Herlev Hospital /ID# 158053
state: Hovedstaden
city: Aalborg
country: Denmark
facility: Aalborg University Hospital /ID# 203737
state: Nordjylland
city: Odense C
country: Denmark
facility: Odense Universitets Hospital /ID# 158054
state: Syddanmark
city: Tallinn
country: Estonia
facility: East Tallinn Central Hospital /ID# 160019
city: Tallinn
country: Estonia
facility: North Estonian Medical Centre /ID# 159779
city: Helsinki
country: Finland
facility: Docrates Cancer Center /ID# 159591
city: Marseille
country: France
facility: CHU Hopital Nord /ID# 160543
state: Bouches-du-Rhone
city: Pessac CEDEX
country: France
facility: Hopital Haut-Lévêque /ID# 160547
state: Gironde
city: Lille
country: France
facility: CHU Calmette /ID# 202706
state: Hauts-de-France
city: Paris CEDEX 05
country: France
facility: Institut Curie /ID# 207514
state: Ile-de-France
city: Lyon CEDEX 08
country: France
facility: Centre Leon Berard /ID# 160550
state: Rhone
city: Creteil
country: France
facility: Centre Hosp Intercommunal de Creteil /ID# 162686
state: Val-de-Marne
city: Paris
country: France
facility: Hopital Tenon /ID# 160541
city: Rennes
country: France
facility: Hospital Pontchaillou /ID# 160544
city: Strasbourg
country: France
facility: Nouvel Hopital Civil (NHC) /ID# 204427
city: Toulouse
country: France
facility: Hopital Larrey /ID# 204290
city: Halle (Saale)
country: Germany
facility: KH Martha-Maria Halle Dolau /ID# 158794
state: Sachsen-Anhalt
city: Berlin
country: Germany
facility: Charite Universitatsmedizin Berlin Campus Virchow Klinikum /ID# 158783
city: Berlin
country: Germany
facility: Evangelische Lungenklinik Berl /ID# 158935
city: Gauting
country: Germany
facility: Asklepios Fachkliniken M. Gaut /ID# 158789
city: Heidelberg
country: Germany
facility: Thoraxklinik Heidelberg gGmbH /ID# 158871
city: Hemer
country: Germany
facility: Lungenklinik Hemer /ID# 158790
city: Kassel
country: Germany
facility: Klinikum Kassel /ID# 158786
city: Löwenstein
country: Germany
facility: Klinik Loewenstein GmbH /ID# 158870
city: Wangen
country: Germany
facility: Fachkliniken Wangen /ID# 160779
city: Cholargos
country: Greece
facility: Metropolitan General Hospital /ID# 202422
state: Attiki
city: Athens
country: Greece
facility: General Hospital of Chest Diseases of Athens SOTIRIA /ID# 159160
city: Athens
country: Greece
facility: Metropolitan Hospital /ID# 159157
city: Heraklion
country: Greece
facility: University General Hospital of Heraklion PA.G.N.I /ID# 202409
city: Ioannina
country: Greece
facility: University Hospital of Ioannin /ID# 159158
city: Nea Kifisia
country: Greece
facility: General Oncological Hospital /ID# 159159
city: Thessaloniki
country: Greece
facility: Euromedica General Clinic /ID# 159156
city: Kowloon
country: Hong Kong
facility: Queen Elizabeth Hospital /ID# 159565
city: Lai Chi Kok
country: Hong Kong
facility: Princess Margaret Hospital /ID# 162810
city: Tuen Mun
country: Hong Kong
facility: Tuen Mun Hospital /ID# 162435
city: Miskolc
country: Hungary
facility: CRU Hungary Egeszsegugyi és Szolgaltato Kft. /ID# 158962
state: Borsod-Abauj-Zemplen
city: Budapest XII
country: Hungary
facility: Orszagos Koranyi Pulmonologiai Intezet /ID# 158953
state: Budapest
city: Nyiregyhaza
country: Hungary
facility: Szabolcs-Szatmar-Bereg Megyei Korhazak es Egyetemi Oktatokorhaz - Pulmonologia /ID# 202466
state: Szabolcs-Szatmar-Bereg
city: Budapest
country: Hungary
facility: Semmelweis Egyetem /ID# 158955
city: Deszk
country: Hungary
facility: Csongrad Megyei Mellkasi Beteg /ID# 158952
city: Dublin 8
country: Ireland
facility: St. James's Hospital /ID# 159712
state: Dublin
city: Cork
country: Ireland
facility: Cork University Hospital /ID# 159715
city: Dublin
country: Ireland
facility: St Vincent's University Hosp /ID# 161678
city: Dublin
country: Ireland
facility: Beaumont Hospital /ID# 159711
city: Limerick
country: Ireland
facility: University Hospital Limerick /ID# 159714
city: Waterford
country: Ireland
facility: University Hospital Waterford /ID# 159713
city: Petakh Tikva
country: Israel
facility: Rabin Medical Center /ID# 159764
state: Tel-Aviv
city: Tel Aviv-Yafo
country: Israel
facility: Tel Aviv Sourasky Medical Center /ID# 161467
state: Tel-Aviv
city: Be'er Sheva
country: Israel
facility: Soroka University Medical Center /ID# 159762
city: Be'er Ya'akov
country: Israel
facility: Assaf Harofeh Medical Center /ID# 201883
city: Haifa
country: Israel
facility: Rambam Health Care Campus /ID# 202336
city: Jerusalem
country: Israel
facility: Hadassah /ID# 159763
city: Kfar Saba
country: Israel
facility: Meir Medical Center /ID# 159761
city: Ramat Gan
country: Israel
facility: Sheba Medical Center /ID# 159760
city: Meldola
country: Italy
facility: IRST IRCCS - Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori /ID# 160898
state: Emilia-Romagna
city: Rome
country: Italy
facility: Policlinico Universitario Campus Bio-Medico /ID# 160874
state: Lazio
city: Arezzo
country: Italy
facility: AUSL 8 Arezzo Ospedale San Don /ID# 160897
city: Orbassano
country: Italy
facility: A.O.U. San Luigi Gonzaga /ID# 158916
city: Ravenna
country: Italy
facility: Ospedale Santa Maria delle Cro /ID# 158911
city: Rome
country: Italy
facility: IFO Istituto Nazionale Tumori /ID# 158912
city: Nagoya-shi
country: Japan
facility: Aichi Cancer Center Hospital /ID# 164976
state: Aichi
city: Kashiwa-shi
country: Japan
facility: National Cancer Center Hospital East /ID# 165721
state: Chiba
city: Fukuoka-shi
country: Japan
facility: Kyushu University Hospital /ID# 165722
state: Fukuoka
city: Kurume-shi
country: Japan
facility: Kurume University Hospital /ID# 164595
state: Fukuoka
city: Kanazawa
country: Japan
facility: Kanazawa University Hospital /ID# 165127
state: Ishikawa
city: Yokohama-shi
country: Japan
facility: Kanagawa Cardiovascular and Respiratory Center /ID# 165015
state: Kanagawa
city: Yokohama-shi
country: Japan
facility: Yokohama City University Hospital /ID# 165746
state: Kanagawa
city: Okayama-shi
country: Japan
facility: Japanese Red Cross Okayama Hospital /ID# 165157
state: Okayama
city: Hirakata-shi
country: Japan
facility: Kansai Medical University Hospital /ID# 165054
state: Osaka
city: Osaka-sayama-shi
country: Japan
facility: Kindai University Hospital /ID# 166395
state: Osaka
city: Sunto-gun
country: Japan
facility: Shizuoka Cancer Center /ID# 166272
state: Shizuoka
city: Tokushima-shi
country: Japan
facility: Tokushima University Hospital /ID# 166105
state: Tokushima
city: Chuo-ku
country: Japan
facility: National Cancer Center Hospital /ID# 166547
state: Tokyo
city: Shinagawa-ku
country: Japan
facility: Showa University Hospital /ID# 165575
state: Tokyo
city: Wakayama-shi
country: Japan
facility: Wakayama Medical University /ID# 165946
state: Wakayama
city: Akashi
country: Japan
facility: Hyogo Cancer Center /ID# 165138
city: Himeji
country: Japan
facility: National Hospital Organization Himeji Medical Center /ID# 165899
city: Matsusaka-shi MIE
country: Japan
facility: Matsusaka City Hospital /ID# 166156
city: Osaka
country: Japan
facility: Osaka City General Hospital /ID# 165714
city: Sapporo
country: Japan
facility: Hokkaido Cancer Center /ID# 165236
city: Sendai
country: Japan
facility: Sendai Kousei Hospital /ID# 166491
city: Yokohama
country: Japan
facility: Kanagawa Cancer Center /ID# 165814
city: Busan
country: Korea, Republic of
facility: Dong-A University Hospital /ID# 159305
state: Busan Gwang Yeogsi
city: Seongnam si
country: Korea, Republic of
facility: CHA Bundang Medical center CHA University /ID# 161281
state: Gyeonggido
city: Daegu
country: Korea, Republic of
facility: Kyungpook National University Chilgok Hospital /ID# 159301
state: Seoul Teugbyeolsi
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center /ID# 159304
state: Seoul Teugbyeolsi
city: Seoul
country: Korea, Republic of
facility: Korea University Guro Hospital /ID# 159302
state: Seoul Teugbyeolsi
city: Cheongju-si
country: Korea, Republic of
facility: Chungbuk National University /ID# 159300
city: Seoul
country: Korea, Republic of
facility: Severance Hospital /ID# 159297
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center /ID# 159299
city: Riga
country: Latvia
facility: Pauls Stradins Clinical /ID# 158715
city: Riga
country: Latvia
facility: Riga East Clinical University /ID# 158716
city: Kovno
country: Lithuania
facility: Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 160016
state: Kaunas
city: Klaipeda
country: Lithuania
facility: Klaipeda University Hospital /ID# 160018
city: Vilnius
country: Lithuania
facility: National Cancer Institute /ID# 160017
city: Morelia
country: Mexico
facility: Centro de Investigación Clinica Chapultepec /ID# 160965
state: Michoacan
city: Ciudad de México
country: Mexico
facility: Health Pharma professional Ser /ID# 160734
city: Amersfoort
country: Netherlands
facility: Meander Medisch Centrum /ID# 159064
city: Arnhem
country: Netherlands
facility: Rijnstate /ID# 159063
city: Breda
country: Netherlands
facility: Amphia Ziekenhuis /ID# 159065
city: Eindhoven
country: Netherlands
facility: Catharina Ziekenhuis /ID# 158082
city: Maastricht
country: Netherlands
facility: Maastricht Universitair Medisch Centrum /ID# 161669
city: S Hertogenbosch
country: Netherlands
facility: Jeroen Bosch Ziekenhuis /ID# 158081
city: Utrecht
country: Netherlands
facility: Universitair Medisch Centrum Utrecht /ID# 158083
city: Nordbyhagen
country: Norway
facility: Akershus universitetssykehus /ID# 201682
state: Akershus
city: Drammen
country: Norway
facility: Drammen Sykehus /ID# 159572
state: Buskerud
city: Bergen
country: Norway
facility: Haukeland University Hospital /ID# 159573
state: Hordaland
city: Trondheim
country: Norway
facility: St. Olavs Hospital HF /ID# 163110
state: Sor-Trondelag
city: Oslo
country: Norway
facility: Radiumhospitalet, OUS /ID# 159574
city: Stavanger
country: Norway
facility: Stavanger Universitetssykehus /ID# 159575
city: Rzeszów
country: Poland
facility: Mrukmed. Lekarz Beata Madej Mruk i Partner /ID# 159604
state: Podkarpackie
city: Bytom
country: Poland
facility: Wojewodzki Szpital Specjalisty /ID# 159603
city: Gdynia
country: Poland
facility: Szpitale Pomorskie Sp. z o.o /ID# 159605
city: Lisbon
country: Portugal
facility: Centro Hospitalar Lisboa Norte, EPE /ID# 159957
state: Lisboa
city: Lisboa
country: Portugal
facility: IPO Lisboa FG, EPE /ID# 159949
city: Lisbon
country: Portugal
facility: Hospital da Luz, SA /ID# 159954
city: Matosinhos
country: Portugal
facility: Unidade Local Saude Matosinhos /ID# 159950
city: Porto
country: Portugal
facility: Centro Hospitalar do Porto EPE /ID# 203582
city: Porto
country: Portugal
facility: Hospital CUF Porto /ID# 159955
city: Porto
country: Portugal
facility: IPO Porto FG, EPE /ID# 159956
city: Moscow
country: Russian Federation
facility: National Medical Research Cntr /ID# 169885
state: Moskovskaya Oblast
city: Arkhangelsk
country: Russian Federation
facility: Arkhangelsk clinical oncology /ID# 159367
city: Kaluga
country: Russian Federation
facility: Kaluga Regional Clinical Oncol /ID# 160180
city: Omsk
country: Russian Federation
facility: Clinical Onco Dispensary /ID# 159365
city: Pushkin
country: Russian Federation
facility: PMI Euromedservice /ID# 159369
city: Pyatigorsk
country: Russian Federation
facility: LLC Novaya Clinica /ID# 205523
city: Saint Petersburg
country: Russian Federation
facility: OOO Centre of Palliative Medicine De Vita /ID# 206855
city: Saransk
country: Russian Federation
facility: Ogarev Mordovia State Univ /ID# 205742
city: Smolensk
country: Russian Federation
facility: Smolensk Regional Onc Clin Dis /ID# 159372
city: St. Petersburg
country: Russian Federation
facility: LLC BioEq Ltd. /ID# 159368
city: St. Petersburg
country: Russian Federation
facility: N.N. Petrov Research Inst Onc /ID# 159370
city: Belgrade
country: Serbia
facility: Clinical Center Serbia /ID# 160902
state: Beograd
city: Belgrade
country: Serbia
facility: Clin Hosp Ctr Bezanijska Kosa /ID# 160903
state: Beograd
city: NIS
country: Serbia
facility: Clinical Center of Nis /ID# 160905
state: Nisavski Okrug
city: Belgrade
country: Serbia
facility: Institut za onkologiju i radio /ID# 160904
city: Sremska Kamenica
country: Serbia
facility: Institute For Pulmonary Diseas /ID# 164250
city: Port Elizabeth
country: South Africa
facility: Cancercare Langenhoven Drive Oncology Centre /ID# 159126
state: Eastern Cape
city: Pretoria
country: South Africa
facility: Dr Albert, Bouwer and Jordaan Incorporated /ID# 158873
state: Gauteng
city: Pretoria
country: South Africa
facility: Mary Potter Oncology Centre /ID# 158877
state: Gauteng
city: Durban
country: South Africa
facility: The Oncology Centre /ID# 158872
state: Kwazulu-Natal
city: Cape Town
country: South Africa
facility: Cape Town Oncology Trials /ID# 201311
state: Western Cape
city: George
country: South Africa
facility: Cancercare Outeniqua Oncology Unit /ID# 200689
state: Western Cape
city: A Coruña
country: Spain
facility: Hospital Teresa Herrera - CHUAC /ID# 164368
state: A Coruna
city: Málaga
country: Spain
facility: Hospital Regional de Malaga /ID# 164371
state: Malaga
city: Barcelona
country: Spain
facility: Hospital Parc de Salut del Mar /ID# 159690
city: Barcelona
country: Spain
facility: Hospital Universitario Vall d'Hebron /ID# 159708
city: Madrid
country: Spain
facility: Hospital Clinico Universitario San Carlos /ID# 159706
city: Madrid
country: Spain
facility: Hospital Universitario Fundacion Jimenez Diaz /ID# 159693
city: Madrid
country: Spain
facility: Hospital Universitario La Paz /ID# 159692
city: Zaragoza
country: Spain
facility: Hospital Clinico Universitario Lozano Blesa /ID# 159709
city: Karlstad
country: Sweden
facility: Centralsjukhuset, Karlstad /ID# 163451
state: Varmlands Lan
city: Göteborg
country: Sweden
facility: Sahlgrenska US Gbg /ID# 159524
state: Vastra Gotalands Lan
city: Linkoping
country: Sweden
facility: University Hospital Linkoping /ID# 159046
city: Solna
country: Sweden
facility: Karolinska Univ Sjukhuset /ID# 159649
city: Uppsala
country: Sweden
facility: Uppsala University Hospital /ID# 159052
city: Genève
country: Switzerland
facility: Hopitaux Universitaires de Geneve /ID# 160603
state: Geneve
city: St. Gallen
country: Switzerland
facility: Kantonsspital St. Gallen /ID# 160604
state: Sankt Gallen
city: Basel
country: Switzerland
facility: Universitaetsspital Basel /ID# 160605
city: Luzern
country: Switzerland
facility: Luzerner Kantonsspital /ID# 160607
city: Winterthur
country: Switzerland
facility: Kantonsspital Winterthur /ID# 161379
city: Taichung City
country: Taiwan
facility: China Medical University Hosp /ID# 158981
state: Taichung
city: Tainan City
country: Taiwan
facility: National Cheng Kung University Hospital /ID# 158799
state: Tainan
city: Taipei City
country: Taiwan
facility: National Taiwan Univ Hosp /ID# 159049
state: Taipei
city: Taipei City
country: Taiwan
facility: Tri-Service General Hospital /ID# 158980
state: Taipei
city: Dalin Township
country: Taiwan
facility: Dalin Tzu Chi General Hospital /ID# 158983
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 158798
city: Taichung City
country: Taiwan
facility: Taichung Veterans General Hosp /ID# 159047
city: Taipei City
country: Taiwan
facility: Taipei Veterans General Hosp /ID# 203699
city: Altindağ
country: Turkey
facility: Hacettepe University Medical Faculty /ID# 159242
state: Ankara
city: Melikgazi
country: Turkey
facility: Erciyes University Medical Fac /ID# 202269
state: Kayseri
city: Ankara
country: Turkey
facility: Ataturk Gogus Hastalikl /ID# 159556
city: Antalya
country: Turkey
facility: Akdeniz Universitesi Tip Fakul /ID# 160791
city: Istanbul
country: Turkey
facility: Bezmi alem Vakif Universitesi /ID# 202267
city: Istanbul
country: Turkey
facility: Istanbul Medeniyet Universites /ID# 200126
city: Izmir
country: Turkey
facility: Ege University Medical Faculty /ID# 159243
city: Izmir
country: Turkey
facility: Dr. Suat Seren Gogus Has /ID# 159244
city: Malatya
country: Turkey
facility: Inonu University /ID# 159245
city: Zaporizhzhia
country: Ukraine
facility: CI Zaporizhzhia Regional Clinical Oncological Dispensary /ID# 159131
state: Zaporizka Oblast
city: Chernivtsi
country: Ukraine
facility: Regional Municipal Non-Profit Enterprise Bukovynian Clinical Oncology Center /ID# 159864
city: Dnipro
country: Ukraine
facility: Municipal institution Multifie /ID# 159130
city: Kharkiv
country: Ukraine
facility: Regional Center of Oncology /ID# 159132
city: Kropyvnytskyi
country: Ukraine
facility: PE PMC Acinus, Medical and Diagnostic Center /ID# 165543
city: Lutsk
country: Ukraine
facility: Volyn Regional Medical Oncology Centre /ID# 159133
city: Uzhhorod
country: Ukraine
facility: Communal Nonprofit Enterprise "Central City Clinical Hospital" of Uzhhorod City /ID# 159865
city: Cheltenham
country: United Kingdom
facility: Cheltenham General Hospital /ID# 169096
state: Gloucestershire
city: Birmingham
country: United Kingdom
facility: Queen Elizabeth Medical Centre /ID# 162899
city: Bournemouth
country: United Kingdom
facility: The Royal Bournemouth Hospital /ID# 159039
city: Colchester
country: United Kingdom
facility: Colchester General Hospital /ID# 159042
city: Hereford
country: United Kingdom
facility: Hereford County Hospital /ID# 159038
city: London
country: United Kingdom
facility: St. George's Healthcare NHS /ID# 202416
city: London
country: United Kingdom
facility: Charing Cross Hospital /ID# 161399
city: Maidstone
country: United Kingdom
facility: Maidstone Hospital /ID# 159043
city: Manchester
country: United Kingdom
facility: Christie NHS Foundation Trust /ID# 159037
city: Newcastle Upon Tyne
country: United Kingdom
facility: The Newcastle Upon Tyne Hospitals NHS Foundation Trust Freeman Hospital /ID# 159044
city: Torquay
country: United Kingdom
facility: Torbay Hospital - So Devon HC /ID# 159041
Study officials:
affiliation: AbbVie
name: AbbVie Inc.
role: STUDY_DIRECTOR
References:
citation: Tanaka K, Isse K, Fujihira T, Takenoyama M, Saunders L, Bheddah S, Nakanishi Y, Okamoto I. Prevalence of Delta-like protein 3 expression in patients with small cell lung cancer. Lung Cancer. 2018 Jan;115:116-120. doi: 10.1016/j.lungcan.2017.11.018. Epub 2017 Nov 22.