Clinical trial NCT06074198: Sickle Cell Children's Exercise Study (SuCCESs)
Official title: Sickle Cell Children's Exercise Study Determining the Effects of a Targeted Exercise Training Program on Neuromuscular Performance, Locomotor Efficiency, and Exercise Tolerance in Children with Sickle Cell Disease.
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Sickle Cell Disease
Keywords: physical therapy
neuromotor performance
functional capacity
Lead sponsor: University of Maryland, Baltimore
Sponsor class: OTHER
First posted: 2023-10-10
Enrollment: 20
Sex: ALL
Minimum age (years): 6
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: feasibility study
Primary purpose: TREATMENT

Brief summary: The Sickle Cell Children's Exercise Study (SuCCESs) will explore the feasibility and effects of a moderate intensity strengthening, balance, speed, and agility intervention program in children with sickle cell disease.

Detailed description: Participants will perform the baseline assessment and after six weeks of performing the SuCCESs program the participants will perform a post-intervention assessment. Participants will be asked to attend a total of six physical therapy in-person sessions (1x/week) at the University of Maryland Department of Physical Therapy and Rehabilitation Science and to perform 12 home program sessions.

Eligibility criteria: Inclusion Criteria:

* Children 6-17 years of age diagnosed with sickle cell disease

Exclusion Criteria:

* Diagnosis of neurological disorder, not related to sickle cell disease
* Lower extremity injury such as a fracture with a cast

Primary outcomes:
measure: knee extension strength
timeFrame: week 1 and week 7
measure: Rate of Muscle Activation
timeFrame: week 1 and week 7
measure: exercise tolerance
timeFrame: week 1 and week 7
measure: locomotor efficiency
timeFrame: week 1 and week 7
measure: number of sessions attended
timeFrame: throughout the entire study week 1, weeks 2-6, six weeks of intervention, and week 7
Secondary outcomes:
Other outcomes:
Locations:
city: Baltimore
country: United States
facility: University of Maryland School of Medicine Dept. of Physical Therapy & Rehabilitation Science
state: Maryland
city: Baltimore
country: United States
facility: University of Maryland, Baltimore
state: Maryland
Study officials:
References:
citation: Marchese V, Rock K, Harpold A, Salazar A, Williams M, Shipper AG. Physical Impairment and Function in Children and Adolescents With Sickle Cell Disease: A Systematic Review. Arch Phys Med Rehabil. 2022 Jun;103(6):1144-1167.e2. doi: 10.1016/j.apmr.2021.08.022. Epub 2021 Sep 27.
citation: Lanza MB, Rock K, Marchese V, Addison O, Gray VL. Hip Abductor and Adductor Rate of Torque Development and Muscle Activation, but Not Muscle Size, Are Associated With Functional Performance. Front Physiol. 2021 Oct 14;12:744153. doi: 10.3389/fphys.2021.744153. eCollection 2021.
citation: Ho S, Rock K, Marchese V. Diaphragm excursion correlates with performance and ventilation on the 6-min walk test in children with sickle cell disease. Pediatr Pulmonol. 2023 Jun;58(6):1665-1673. doi: 10.1002/ppul.26373. Epub 2023 Mar 8.
citation: Rock K, Nelson C, Addison O, Marchese V. Assessing the Reliability of Handheld Dynamometry and Ultrasonography to Measure Quadriceps Strength and Muscle Thickness in Children, Adolescents, and Young Adults. Phys Occup Ther Pediatr. 2021;41(5):540-554. doi: 10.1080/01942638.2021.1881200. Epub 2021 Feb 9.