Clinical trial NCT06897306: Gastric-type Endocervical Adenocarcinoma: a Population-based Cohort Study
Official title: Surgery Significantly Improves the Prognosis of Locally Advanced Gastric-type Endocervical Adenocarcinoma: a Population-based Cohort Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Uterine Cervical Neoplasms
Surgery
Therapy
Locally Advanced Cervical Carcinoma
Keywords: Uterine Cervical Neoplasms
cervical cancer
Gastric - type Mucinous Adenocarcinoma
surgery
Lead sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Sponsor class: OTHER
First posted: 2025-03-26
Enrollment: 317
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The Surveillance, Epidemiology, and End Results (SEER) database is a comprehensive source of population - based cancer incidence and survival data in the United States. The population covered by the SEER database is diverse and representative of the broader U.S. population. It includes individuals from various racial and ethnic backgrounds, age groups, and geographic regions. The data are collected from 17 population - based cancer registries, which cover approximately 28% of the U.S. population. This allows for the analysis of cancer - related outcomes and trends across different demographic and socioeconomic groups, providing valuable insights into the burden of cancer and the effectiveness of cancer - related interventions in a population - based setting.

Brief summary: This study aims to collect data of patients with Gastric-type Endocervical Adenocarcinoma from the SEER database, analyze the related prognostic factors and treatment patterns of Gastric-type Endocervical Adenocarcinoma, and explore the impact of surgical treatment on the prognosis of locally advanced Gastric-type Endocervical Adenocarcinoma.

Detailed description: This study aims to collect data of patients with Gastric - type Endocervical Adenocarcinoma from the SEER database, analyze the related prognostic factors and treatment patterns of patients with Gastric - type Endocervical Adenocarcinoma, and explore the impact of surgical treatment on the prognosis of locally advanced Gastric - type Endocervical Adenocarcinoma.

Study subjects: Patients diagnosed with Gastric - type Endocervical Adenocarcinoma were identified using the SEER database and SEER\*Stat 8.4.2 software. The search scope was the "SEER Research Plus Data, 17 Registries, Nov 2021 sub (2000 - 2019)" database, and the screening criteria included "Site and Morphology, Analytic Behavior Recode = Malignant" and "Site and Morphology, ICD - O - 3 / WHO 2008 Recode Site = Cervix". Patients with cervical Gastric - type Endocervical Adenocarcinoma were selected from the database.

Outcome measures: Overall survival (OS): The time from diagnosis to death of the patient.

Eligibility criteria: Inclusion Criteria:

* Patients diagnosed with Gastric - type Endocervical Adenocarcinoma were identified using the SEER database and SEER\*Stat 8.4.2 software. The search scope was the "SEER Research Plus Data, 17 Registries, Nov 2021 sub (2000 - 2019)" database. The screening criteria included "Site and Morphology, Analytic Behavior Recode = Malignant" and "Site and Morphology, ICD - O - 3 / WHO 2008 Recode Site = Cervix". Patients with Gastric - type Endocervical Adenocarcinoma in the database were selected.

Exclusion Criteria:

* Patients with a survival time of 0 or unknown.

Primary outcomes:
measure: Overall survival (OS)
timeFrame: The time from diagnosis to death of the patient，Assessed up to 227 months
Secondary outcomes:
measure: Vital status recode(study cutoff used)
timeFrame: up to 227 months
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: The Sun Yat-Sen Memorial Hospital of Sun Yat-Sen Universit
state: Guangdong
Study officials:
affiliation: The Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
name: Huaiwu Lu
role: STUDY_DIRECTOR
References: