Clinical trial NCT03732053: The Effectiveness of Global Postural Reeducation on Alzheimer Disease Patients
Official title: The Effectiveness of Physical Rehabilitation in the Enhancement of Proprioceptive and Cognitive Aspects on Alzheimer Disease Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Alzheimer's Type Dementia
Cognitive Decline
Postural; Strain
Lead sponsor: Universidad Católica San Antonio de Murcia
Sponsor class: OTHER
First posted: 2018-11-06
Enrollment: 135
Sex: ALL
Minimum age (years): 40
Maximum age (years): 95
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomized Controlled Trial
Primary purpose: TREATMENT

Brief summary: This research study is developed on an experimental design with randomized controlled intervention were participated 135 subjects with AD including 45 of the control group. It lasted 6 months with pre-post tests (T0-T1) executed before and after six months of treatment. By having in focus the evaluation of GPR therapy effects on cognitive, proprioceptive, depressive, autonomy, gait and life quality of the above mentioned subjects.

Detailed description: In order to assess the cognitive abilities of the patients a cognitive test was administered which acts through a scale concerning depression and mood evaluation as well as a questionnaire was developed aiming to evaluate the examined subjects' functional abilities: Mini Mental State Examination (MMSE), Quality of Life in Alzheimer Disease (QoL-AD), geriatric Depression Scale (GDS), Barthel Index (BI), Neuropsychiatric Inventory (NPI), Tinetti Scale (TS).

Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of Alzheimer's Disease
* Older than 40 years of age
* Male and female
* Intellectual disability
* Cognitive impairment
* Able to do daily activities on his own
* No presence of any other neurological and psychological disease
* No presence of brain tumors

Exclusion Criteria:

* No presence of Alzheimer's Disease
* Under 40 years old
* Presence of brain tumors
* Neurological patients
* Presence of psychiatric disease
* Depression symptoms
* Presence of neuromuscular disease
* Ictus
* Aggressive patients

Primary outcomes:
measure: Cognitive Abilities Measurement
timeFrame: Change from baseline cognitive evaluation at 6'th month
Secondary outcomes:
measure: Quality of Life in Alzheimer's disease (QoL-AD) Questionnaire
timeFrame: Change from baseline cognitive evaluation at 6'th month
measure: Geriatric Depression Scale (GDS) Questionnaire
timeFrame: Change from baseline cognitive evaluation at 6'th month
measure: Barthel Index (BI)
timeFrame: Change from baseline cognitive evaluation at 6'th month
measure: Neuropsychiatric Inventory (NPI)
timeFrame: Change from baseline cognitive evaluation at 6'th month
measure: Tinetti Scale (TS)
timeFrame: Change from baseline cognitive evaluation at 6'th month
Other outcomes:
Locations:
Study officials:
References:
citation: Todri J, Lena O, Todri A, Fuentes JM. Does the Global Postural Re-Education Affect the Psychological and Postural Aspects of Alzheimer Disease Patients? A Six Months Quasi-Experimental Study. Curr Alzheimer Res. 2021;18(13):1057-1065. doi: 10.2174/1567205019666211223094811.