Clinical trial NCT02506205: The Effect of LSVT LOUD for Mandarin-speaking Individuals With Hypokinetic Dysarthria Due to Parkinson's Disease
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Hypokinetic Dysathria
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2015-07-23
Enrollment: 40
Sex: ALL
Minimum age (years): 30
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: A handful of studies have examined the effects of the Lee Silverman Voice Treatment (LSVT) LOUD on hypokinetic dysarthria in English speakers with Parkinson's disease (PD). Although LSVT LOUD has been found to be effective on improving these speaker's vocal intensity and increasing their speech intelligibility as well as speech function with Phase I evidence, no study has investigated whether Mandarin-speaking individuals with dysarthria secondary to PD would benefit from LSVT LOUD. In the proposed study, speech data of Mandarin-speaking individuals with hypokinetic dysarthria before and after speech therapy will be audio recorded and analyzed in order to examine the effects of LSVT LOUD on the speech function in this population. The same speech data will be played to Mandarin listeners in order to investigate the speech intelligibility of this population. It is hypothesized that Mandarin-speaking individuals with hypokinetic dysarthria secondary to PD will demonstrate reduced vocal intensity, reduced speech intelligibility and impaired speech function before they receive LSVT LOUD. They will improve these speech characteristics following speech therapy and will present with short-term maintenance effects.


Eligibility criteria: Inclusion Criteria:

1. Mandarin-speaking Taiwanese
2. Hypokinetic dysarthria due to Parkinson's disease
3. No other neurodegenerative diseases
4. No cognitive deficits
5. Age range 30 years and above

Exclusion Criteria:

1. Not able to follow verbal directions,
2. speech characteristics uncommon to Parkinson's disease

Primary outcomes:
measure: Speech intelligibility
timeFrame: Immediate
Secondary outcomes:
measure: Speech function
timeFrame: Immdediate
Other outcomes:
measure: Quality of life measured by PDQ-39
timeFrame: Immediate
measure: Depression level measured by BDI-II
timeFrame: Immediate
measure: Cognitive status measured by MMSE
timeFrame: Immediate
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
Study officials:
References:
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