Clinical trial NCT04864132: The Investigation Of Exercise Capacity And Exercise-Induced Fatigue in Young Adults Who Survived From Coronavirus
Official title: The Investigation Of Exercise Capacity And Exercise-Induced Fatigue in Young Adults Who Survived From Coronavirus
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Covid19
Keywords: coronavirus
exercise capacity
Lead sponsor: Biruni University
Sponsor class: OTHER
First posted: 2021-04-28
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The subjects who survived from COVID-19 aged between 18-30 and healthy individuals in the same age will be included in the project.

Brief summary: The effects of Coronavirus Disease (COVID-19), a multisystem disease, on the body system and functions are being investigated all over the world. Examining the effect of exercise capacity, which is an important marker of cardiovascular risk in young individuals with COVID-19, will allow the planning of exercise and physical activity programs according to the needs of that specific population. The objectives of this project are:(1) To compare the submaximal and maximal exercise capacity of young adults aged between 18-30 who have had COVID-19 with healthy individuals in the same age group (2) To determine the roles of muscle strength, respiratory functions, fatigue, dyspnea, and physical activity level on exercise capacity evaluated by two different tests in young adults survived from COVID-19.

Detailed description: The effects of COVID-19, a multisystem disease, on the body system and functions are being investigated worldwide. For young adults, exercise capacity is vital in the workforce, cardiovascular risk factors and long-term health perception. Determining exercise capacity, which is an essential indicator of cardiovascular risk in the long term, and determining the factors affecting exercise capacity in cases with COVID-19 will allow the planning of exercise and physical activity programs according to young people's needs. The objectives of this project are:(1) To compare the submaximal and maximal exercise capacity of young adults aged between 18-30 who have had COVID-19 with healthy individuals in the same age group (2) To determine the roles of muscle strength, respiratory functions, fatigue, dyspnea, and physical activity level on exercise capacity evaluated by two different tests in young adults survived from COVID-19. There is no study in the literature evaluating the exercise capacity and the factors affecting the prolonged COVID-19 symptoms for patients with COVID-19. This project can provide objective evidence on this subject and includes controlled multi-directional measurement.

Eligibility criteria: Inclusion Criteria:

* For cases with COVID-19:

Confirmed COVID-19 infection - For healthy individuals of the same age group who have not had COVID-19: Individuals who have not been diagnosed with COVID-19 as of March 11, 2020 and who have not been in contact and risky according to the "Life Fits Into Home" application

- For all participants; Answering "No" to all questions in the Physical Activity Readiness Questionnaire.

Exclusion Criteria:

* Individuals with orthopedic or neurological disabilities that may interfere with exercise testing,
* Individuals with a fever\> 38 ° C and / or resting blood pressure \<90/60 mmHg or\> 140/90 mmHg and/or oxygen saturation ≤95%,
* Individuals who have been involved in a physiotherapy and rehabilitation program within the last 3 months,
* Individuals with insufficient cooperation
* Individuals with blood coagulation disorders contraindicated for blood lactate analysis,
* Pregnant women or individuals with suspected pregnancy

Primary outcomes:
measure: Submaximal and maximal exercise tests
timeFrame: 1 year
Secondary outcomes:
measure: Fatigue Severity Scale
timeFrame: 1 year
measure: Dyspnea-12 Scale
timeFrame: 1 year
measure: International Physical Activity Questionnaire-Short Form (IPAQ)
timeFrame: 1 year
measure: Forced expiratory volume in first second (FEV1) (predicted %)
timeFrame: 1 year
measure: Peripheral muscle strength
timeFrame: 1 year
measure: Respiratory muscle strength
timeFrame: 1 year
measure: Forced vital capacity (FVC) (predicted %)
timeFrame: 1 year
measure: FEV1/FVC (predicted %)
timeFrame: 1 year
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Biruni University
Study officials:
affiliation: Biruni University
name: Buket Akinci, Assoc. Prof.
role: STUDY_CHAIR
affiliation: Biruni University
name: Zeynep Hosbay, Assoc. Prof.
role: PRINCIPAL_INVESTIGATOR
References: