louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02615028: Development of Novel Designed Force Plate for Measuring the Balance Ability for the Elders
Official title: Kaohsiung Medical University Chung-Ho Memorial Hospital Institutional Review Board
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Keywords: Force plate, Balance ability
Lead sponsor: Kaohsiung Medical University Chung-Ho Memorial Hospital
Sponsor class: OTHER
First posted: 2015-11-25
Enrollment: 40
Sex: ALL
Minimum age (years): 20
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP

Brief summary: To develop a force plate with a proper computing algorithm that can be used in the average household as well as within community care centers. An affordable price range will also be necessary.

Detailed description: Many studies using force plates to examine the elders' balance ability for fall prevention. However, few studies compare the reliability differences among age in postural sway measurements even though many studies find significantly greater postural sway in the elder population than compared to the younger cohort. Investigation of this age difference is important for choosing variables to represent their postural sway improvement in order to determine the intervention outcome.

Eligibility criteria: Inclusion Criteria:

* Young adults between 20 and 25 yrs
* Seniors between 67 to 75 yrs.

Exclusion Criteria:

* Lower limb neuromuscular diseases
* Musculoskeletal injuries
* Any negative response

Primary outcomes:
measure: Center of Pressure (COP)
timeFrame: 40 seconds.
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Department of Sports Medicine, College of Medicine, Kaohsiung Medical University
name: Lan Y Guo, Ph.D
role: STUDY_CHAIR
References:
citation: Corriveau, H, Hébert R, Prince F, Raîche M. Postural control in the elderly: an analysis of test-retest and interrater reliability of the COP-COM variable. Arch Phys Med Rehabil 82(1): 80-85, 2001 Lafond D, Corriveau H, Prince F. Postural control mechanisms during quiet standing in patients with diabetic sensory neuropathy. Diabetes Care 27(1):173-178, 2004 Tinetti ME. Factors associated with serious injury during falls by ambulatory nursing home residents. J Am Geriatr Soc 35(7): 644-648, 1987. Woollacott MH, Shumway-Cook A, Nashner LM. Aging and posture control: changes in sensory organization and muscular coordination. Int J Aging Hum Dev 23(2): 97-114, 1986. 5. Sheldon JH. The effect of age on the control of sway. Gerontol Clin (Basel). 1963; 5: 129-138.
Clinical trial NCT02816528: Efficacy of Information System Regarding the Consumption of Antibiotics and Bacterial Resistance in Primary Care
Official title: Efficacy of Information System Regarding the Consumption of Antibiotics and Bacterial Resistance on the Use of Antibiotics in Primary Care
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Chronic Disease
Keywords: Antibiotics
Primary care
Stewardship
General practitioners
Lead sponsor: Central Hospital, Nancy, France
Sponsor class: OTHER
Collaborators: name: Direction Générale de l'Offre de Soins
name: CNAMTS, Caisse Nationale d'Assurance Maladie des Travailleurs salariés, France
name: MedQual, Nantes, France
First posted: 2016-06-28
Enrollment: 472
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: General practitioners

Brief summary: France is a country strong consumer of antibiotics in Europe, specially in primary care.

Outpatient antibiotic use represents around 90% of total antibiotic use and prescriptions come mainly from general practitioners. A literature review of antibiotic stewardship in primary care show that there is no evaluation of interest of giving information about consumption of antibiotics and bacterial resistance to general practitioners. The objective of this study is to demonstrate that practitioners implicated in the followed of consumption of antibiotics and bacterial resistance around their geographical area of practice could change and improve their practices in good use of antibiotics.


Eligibility criteria: Inclusion Criteria:

* General practitioners in a "Meurthe-et-Moselle" french department

Exclusion Criteria:

* General practitioners out of "Meurthe-et-Moselle" french department

Primary outcomes:
measure: Consumption of antibiotics
timeFrame: 36 months
Secondary outcomes:
measure: Bacterial resistance of Escherichia coli and Staphylococcus aureus
timeFrame: 36 months
Other outcomes:
Locations:
Study officials:
affiliation: Centre Hospitalier Régional Universitaire, Brabois, Pharmacy
name: Béatrice DEMORE
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06355128: A Cross-sectional Study of Ocular Manifestations During the Covid-19 Pandemic in Hubei Province
Official title: A Cross-sectional Study of Ocular Manifestations During the Covid-19 Pandemic in Hubei Province
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: COVID-19
Ocular Surface Disease
Lead sponsor: Zhongnan Hospital
Sponsor class: OTHER
Collaborators: name: Qichun People's Hospital
First posted: 2024-04-09
Enrollment: 16000
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: People from Hubei Province, China

Brief summary: To investigate the clinical features of ocular manifestations during the novel coronavirus pneumonia pandemic in Hubei at the end of 2022

Detailed description: During late 2022 COVID-19 pandemic ocular discomforts were common in people with mild systemic symptoms, but most resolve on their own without any treatment. The disease spectrum of ophthalmology outpatient clinics is affected by the COVID-19 pandemic. In our study, we observed that the incidence of keratitis and acute angle-closure glaucoma in Phase A was significantly higher than that in Phase B and C.

Eligibility criteria: Inclusion Criteria:

* 1. 2022.12.7 to 2023.2.6 People surveyed by wechat Questionnaire Star 2. 2021.12.7 to 2022.1.6 and 2022.11.7 to 2023.1.6 Patients who received ophthalmology treatment in Zhongnan Hospital of Wuhan University and Qichun People's Hospital

Exclusion Criteria:

* 1. currently hospitalized patients. 2. severe patients. 3. Incomplete information. 4. cannot be contacted by telephone. 5. Refuse questionnaire survey. 6.The electronic medical record information is incomplete. 7. Those who do not go to the ophthalmic clinic after registration. 8.severe patients. 9. Cannot be contacted by phone.

Primary outcomes:
measure: Questionnaire data were collected and statistically analyzed.
timeFrame: 1/4/2024-30/4/2024
Secondary outcomes:
Other outcomes:
Locations:
city: Wuhan
country: China
facility: Zhongnan Hospital of Wuhan University
state: Hubei
Study officials:
References:
Clinical trial NCT00938028: Metabolome and Microbiomic in Fecal Samples
Official title: Fecal Samples for Metabolomic and Microbiomic Studies: Effects of Preparation and Storage
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Infant
Keywords: microbiome
metabolome
stool
fecal samples
handling
toddler
Lead sponsor: Massachusetts General Hospital
Sponsor class: OTHER
First posted: 2009-07-13
Enrollment: 4
Sex: ALL
Minimum age (years): 12
Maximum age (years): 20
Standard ages: CHILD
Accepts healthy volunteers: yes
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Healthy toddlers in a day care center

Brief summary: The purpose of this study is to evaluate the effects of storage and handling on fecal samples collected for metabolomic, proteomic and microbiomic and analysis.

Detailed description: Background

Human fecal collection for clinical or research studies usually occurs at the residence of the subject, an environment not equipped with measures to accommodate proper preparation and storage of samples for microbiome and metabolome analysis.

Aims

To evaluate the effects of storage and handling on fecal samples collected for metabolomic, proteomic and microbiomic and analysis.

Methods

Fecal samples will be collected within several minutes of voiding from healthy infants at the time of diaper change at day-care center.

Samples will be divided into 7 tubes, and subjected to different storage temperatures, before preforming microbial analysis by DNA sequencing, and metabolome analysis by H1NMR spectroscoty.

Eligibility criteria: Inclusion Criteria:

* healthy
* age 12-20 months

Primary outcomes:
measure: Microbiome and metabolome yield
timeFrame: one month
Secondary outcomes:
Other outcomes:
Locations:
city: Boston
country: United States
facility: MassGeneral for Children
state: Massachusetts
Study officials:
affiliation: MGH
name: Harland Winter, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00782028: Integrating Well-Woman and Well-Baby Care to Improve Parenting and Family Wellness
Official title: Integrating Well-Woman and Well-Baby Care to Improve Parenting and Family Wellness
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Primary Care
Keywords: primary care, high-risk families, maternal depression
Lead sponsor: Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Sponsor class: NIH
First posted: 2008-10-29
Enrollment: 170
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: We hypothesize that relative to families who receive standard individual postpartum and pediatric care, families that receive group care will be more likely to have:

* Improved maternal and child health behaviors: i.e increased breastfeeding, exercise, child safety measures in the home and decreased smoking.
* Better health care use for babies: i.e. attend more care visits, on-time and complete immunizations and decreased emergency services use.
* Better psychosocial outcomes for the families: i.e. decreased stress and depression, and increased social support.
* Improved parenting skills: i.e. improved knowledge of child development, involvement in developmentally appropriate activities, and parental sense of competence.


Eligibility criteria: Inclusion Criteria:

* Postpartum woman with baby in her care
* Receive well-woman care, well-child care and interviews in English
* Willingness to receive care in a group setting
* Woman planning to receive care at the Yale Women's Center for herself and the Primary Care Center for her baby

Exclusion Criteria:

* severe medical problem requiring individualized care for mother or baby
* Baby born at less than 37 weeks gestation
* Baby remaining in hospital when mother getting discharged for any other reason except hyperbilirubinemia
* Baby with severe cardiac, respiratory, neuro-developmental or surgical problems

Primary outcomes:
measure: Improved maternal and child health behaviors will be measured using a computer assisted interview.
timeFrame: Interviews will be given at 2 weeks, 6 and 12 months of age.
Secondary outcomes:
measure: Better health care utilization for babies will be measured using Medical records review.
timeFrame: 1 year
measure: Better psychosocial outcomes for mothers, fathers and babies will be measured using a computer assisted interview.
timeFrame: 2 weeks, 6 months and 12 months of age
measure: Improved parenting skills will be assessed using a computer assisted inteview.
timeFrame: 2 weeks, 6 months ad 12 months
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05333328: OFS in Premenopausal Node+ Breast Cancer With Low Genomic Risk
Official title: Endocrine Therapies With Ovarian Function Suppression in Premenopausal Node+ Early Breast Cancer With Low Genomic Risk (INTERSTELLAR Trial, KBCSG-25)
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE4
Conditions: Breast Cancer
Estrogen Receptor Positive Tumor
HER2-negative Breast Cancer
Premenopausal Breast Cancer
Node-positive Breast Cancer
Keywords: Breast Cancer
Estrogen Receptor Positive Tumor
HER2-negative Breast Cancer
Premenopausal Breast Cancer
Node-positive Breast Cancer
Multigene assay
Ovarian-function suppression
Lead sponsor: Gangnam Severance Hospital
Sponsor class: OTHER
Collaborators: name: Seoul National University
First posted: 2022-04-18
Enrollment: 418
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: De-escalating treatment as ovarian-function suppression with endocrine treatments alone in ER+HER2- premenopausal women with N1
Primary purpose: TREATMENT

Brief summary: Among ER+HER2- premenopausal patients with N1 who undergoes primary breast surgery, we will identify the patients with a genomic low risk using the multigene-assay (OncoFREE®).

In these, ovarian function suppression with endocrine therapies including either tamoxifen or aromatase-inhibitors will be administered for 5 years.

Detailed description: * Among ER+HER2- premenopausal patients with N1 who undergoes primary breast surgery, we will identify the patients with a genomic low risk using the multigene-assay (OncoFREE®).
* In these, ovarian function suppression (OFS) with endocrine therapies including either tamoxifen or aromatase-inhibitors will be administered for 5 years.
* Either goserelin acetate or leuprorelin Acetate is allowed.
* These patients are able to choose bilateral salpingo-oophorectomy instead of OFS.
* Chemotherapy is omitted in these patients.

Eligibility criteria: Inclusion Criteria:

* ER+HER2- breast cancer
* Premenopausal and age \<=50
* T1 or T2
* N1 including micrometastasis
* Genomic Low Risk by OncoFREE test® (1-20)

Exclusion Criteria:

* Postmenopausal women
* ER-negative breast cancer

Primary outcomes:
measure: Distant recurrence-free survival
timeFrame: 5-years distant recurrence-free survival
Secondary outcomes:
measure: Recurrence-free survival (RFS)
timeFrame: 5-years RFS
measure: Invasive disease-free survival (iDFS)
timeFrame: 5-years iDFS
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Gangnam Severance Hospital
state: Korea
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
Study officials:
affiliation: Gangnam Severance Hospital
name: Sung Gwe Ahn, M.D.,Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT07002528: The Effectiveness of Sweet Solution Versus Cryotherapy in Reducing Pain During Administration of Local Anesthesia Among Children
Official title: The Effectiveness of Sweet Solution Versus Cryotherapy in Reducing Pain During Administration of Local Anesthesia Among Children
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Pain
Keywords: Dental pain
Anesthesia
Sucrose
Cryotherapy
Topical anesthesia
Lead sponsor: Mansoura University
Sponsor class: OTHER
First posted: 2025-06-03
Enrollment: 180
Sex: ALL
Minimum age (years): 7
Maximum age (years): 11
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Selected children will be divided randomly into 3 groups:

Sucrose group (Group I). Cryotherapy group (Group II). Control group topical anesthesia (Group III).
Primary purpose: OTHER

Brief summary: the porpose of study to assess The Effectiveness of Sweet Solution Versus Cryotherapy in Reducing Pain During Administration of Local Anesthesia Among Children

Detailed description: This study to assess The Effectiveness of Sweet Solution Versus Cryotherapy in Reducing Pain During Administration of Local Anesthesia Among Children

Eligibility criteria: Inclusion Criteria:

1. Children with behavior rating score 2,3 or 4 of Frankl's behavior rating scale
2. children aged 6-11 years requiring dental injections for pulpectomy, root canal treatment, or extraction procedures for primary and permanent mandibular molars.

Exclusion criteria:

1. Allergy to lidocaine
2. Redness at the site of injection؛ and a history of abscess, sinus tract, or fistula associated with the teeth.
3. Children with special health care needs.
4. Children suffering from systemic diseases.
5. Extremely uncooperative children.

Primary outcomes:
measure: VAS
timeFrame: up to twelve weeks
measure: FLACC scale
timeFrame: up to twelve weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Mansoura
country: Egypt
facility: Mansoura university
state: Dakahilia
Study officials:
affiliation: Researcher of Pediatric Dentistry Faculty of Dentistry Mansoura University
name: Manwa Ahmed Ayed, Master
role: STUDY_CHAIR
affiliation: Prof. of Pediatric Dentistry and Dental Public Health Faculty of Dentistry Mansoura University
name: Salwa M Awad, prof
role: STUDY_DIRECTOR
affiliation: assistant Prof. of Pediatric Dentistry and Dental Public Health Faculty of Dentistry Mansoura University
name: Ahmed Hamdy Wahba, Assistant professor
role: STUDY_DIRECTOR
References:
Clinical trial NCT02041728: The Detection of Early Dementia With the Digital Game Memory
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Alzheimer's Disease
Lead sponsor: Universitaire Ziekenhuizen KU Leuven
Sponsor class: OTHER
First posted: 2014-01-22
Enrollment: 20
Sex: ALL
Minimum age (years): 75
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: * healthy subjects of 75 or older
* subjects with mild dementia of 75 or older

Brief summary: The investigators are going to test if it is possible to detect early dementia with the digital game "memory". The investigators are going to test 15 healthy people and 15 patients with early dementia.

The test consists of playing the game "memory" several times. While playing, several parameters are stored.

The investigators are going to test if any correlation can be found between these parameters and the cognitive state of the person as tested by the Mini-Mental status examination.


Eligibility criteria: Inclusion Criteria:

* healthy 75-plusser
* 75-plusser with early dementia

Exclusion Criteria:

* younger than 75
* patient with other cognitive impairments than dementia

Primary outcomes:
measure: Association of cognitive status with failures in a computerised memory game
timeFrame: The game will be played once during 10-30 minutes.
Secondary outcomes:
Other outcomes:
Locations:
city: Leuven
country: Belgium
facility: UZ Leuven
state: Vlaams-Brabant
Study officials:
affiliation: University of Leuven
name: Jos Tournoy
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02080728: Transversus Abdominis Plane Block During Kidney Transplant Surgery
Official title: Transversus Abdominis Plane Block During Kidney Transplant Surgery: Prospective Controlled Randomized Double-blind Trial Comparing Ropivacaine 0.2% With Placebo.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Kidney Transplant
Lead sponsor: Centre Hospitalier Universitaire Dijon
Sponsor class: OTHER
First posted: 2014-03-06
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: The surgeon places the catheter in the thickness of the oblique internal and transverse muscles at the moment the wall is closed, under visual control. A multiperforated catheter whose length corresponds to that of the incision is chosed. The catheter will deliver one of two products chosen at random: either ropivacaine or placebo.

This study will evaluate postoperative pain during the first 24 hours thanks to a recognized indicator the VAS (Visual Analogue pain Scale). The total consumption of analgesics will also be recorded, starting with the titration of morphine in the post-op room, and then the consumption of classical analgesics in the nephrology department. These will only be given if the VAS score is equal to 4 or above.

This is a prospective, single-centre, controlled, double blind study of ropivacaïne 0.2% versus placebo in continuous TAP block during the first 24 hours after the operation in patients undergoing kidney transplant surgery.


Eligibility criteria: Inclusion Criteria:

* Patient opéré for kidney transplant
* Patients who have provided written informed consent
* Patients with national health insurance cover
* Patients aged 18 years and above

Exclusion Criteria:

* Pregnant or breast-feeding women
* allergies/hypersensitivity to paracetamol (or propacetamol chlorhydrate (paracetamol pro-drug) or one of its excipients), to local anesthetics, morphines (or other constituents)
* patients under guardianship or ward of court

Primary outcomes:
measure: Mesurement of VAS (Visual analogue scale) scores for pain
timeFrame: During the first 24 hours post-op
Secondary outcomes:
measure: Measurement of analgesic consomption
timeFrame: During the first 24 hours post-op
Other outcomes:
Locations:
city: Dijon
country: France
facility: CHU de DIJON
Study officials:
References:
Clinical trial NCT05823428: Arthroscopic Biological Augmentation With Subacromial Bursa for Bursal Side Partial-thickness Rotator Cuff Tears
Official title: Arthroscopic Biological Augmentation With Subacromial Bursa for Bursal Side Partial-thickness Rotator Cuff Tears
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Partial Thickness Rotator Cuff Tears
Keywords: partial thickness
bursal side
rotator cuff
full thickness
subacromial bursa
Lead sponsor: Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization
Sponsor class: OTHER
First posted: 2023-04-21
Enrollment: 40
Sex: ALL
Minimum age (years): 25
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The investigators aimed to compare the results of acromioplasty + arthroscopic debridement and acromioplasty + augmentation with subacromial bursa.


Eligibility criteria: Inclusion Criteria:

* bursal side rotator cuff tears in MRI sections
* Patients whose pain does not go away despite NSAIDs and standardized physical therapy by the same physiotherapist applied for 3 months
* 25-50% or 3-6 mm rotator cuff tear (Ellman grade 2) on the bursal side

Exclusion Criteria:

* Previous surgery
* tears greater than 50% or 6 mm

Primary outcomes:
measure: Evaluation of biological augmentation with bursa using postoperative clinical scores and MRI.
timeFrame: 18 months
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: SBU Prof. Cemil Tascioglu City Hospital
Study officials:
References: