Clinical trial NCT05198661: Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis Collection
Official title: Paraneoplastic Neurological Syndromes and Autoimmune Encephalitis Collection
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Paraneoplastic Neurological Syndromes or Autoimmune Encephalitis
Keywords: Paraneoplastic Neurological Syndromes
Autoimmune Encephalitis
biological collection
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2022-01-20
Enrollment: 3500
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Blood sample
Primary purpose: OTHER

Brief summary: Numerous neurological disorders affecting the central and peripheral nervous system can be attributed to the immune system through multiple effector mechanisms. However, current treatments could be drastically improved by faster and more accurate diagnosis. The sample collection will benefit to patients with rare neuroimmune syndromes such as Autoimmune Encephalitis (AE) and Paraneoplastic Neurological Syndromes (PNS) leading to a better and early diagnosis, as well as treatment improvement.


Eligibility criteria: Inclusion Criteria:

* Patient with consent
* Patient with well-characterized antibodies in serum or cerebrospinal fluid or not
* Patient with neurological disorder compatible with PNS or auto-immune encephalitis

Exclusion Criteria:

* Refusal of consent
* Patient under guardianship

Primary outcomes:
measure: Blood Samples
timeFrame: 10 years
measure: Cerebrospinal fluid biocollection
timeFrame: 10 years
Secondary outcomes:
measure: Scientific collaboration
timeFrame: 10 years
measure: Scientific
timeFrame: 10 years
Other outcomes:
Locations:
city: POINTE-à-pitre
country: France
facility: Neurology
state: Guadeloupe
city: Aix-en-Provence
country: France
facility: Neurology
city: Amiens
country: France
facility: Neurologie
city: Angers
country: France
facility: Neurology
city: Annecy
country: France
facility: General neurology
city: Avignon
country: France
facility: Neurology
city: Bayonne
country: France
facility: Neurologie
city: Besançon
country: France
facility: Neurology
city: Bobigny
country: France
facility: Neurology
city: Bordeaux
country: France
facility: Neurology
city: Brest
country: France
facility: Neurology
city: Cannes
country: France
facility: Intensive care medicine
city: Chambéry
country: France
facility: Neurologie
city: Clermont-Ferrand
country: France
facility: Neurology
city: Colmar
country: France
facility: Neurologie
city: Créteil
country: France
facility: Neurology
city: Dijon
country: France
facility: General, Vascular and Degenerative Neurology
city: Gap
country: France
facility: Internal and general practitioner
city: Grenoble
country: France
facility: Neurologie
city: La Roche-sur-Yon
country: France
facility: Neurology
city: Lille
country: France
facility: Neurology
city: Lille
country: France
facility: Neurology
city: Limoges
country: France
facility: Neurology
city: Lisieux
country: France
facility: Neurology
city: Lyon
country: France
facility: Centre de référence des syndromes neurologiques paranéoplasiques et encéphalites autoimmunes
city: Marseille
country: France
facility: Adult Neurology and Neuropsychology
city: Marseille
country: France
facility: Neurologie
city: Marseille
country: France
facility: Neurology
city: Metz
country: France
facility: Neurology
city: Montivilliers
country: France
facility: Neurology
city: Montpellier
country: France
facility: General Neurology
city: Mulhouse
country: France
facility: General medicine
city: Mâcon
country: France
facility: Neurology
city: Nancy
country: France
facility: Neurologie
city: Nantes
country: France
facility: Neurology
city: Nice
country: France
facility: Neurologie
city: Nîmes
country: France
facility: Neurology
city: Paris
country: France
facility: Neurology
city: Paris
country: France
facility: Neuropediatrics
city: Paris
country: France
facility: Intensive Care Medicine
city: Paris
country: France
facility: Neurology
city: Paris
country: France
facility: Onco-neurology
city: Paris
country: France
facility: Neurology adult
city: Poitiers
country: France
facility: Neurology, neuropsychology and language rehabilitation
city: Reims
country: France
facility: Neurology
city: Rennes
country: France
facility: Neurology
city: Rouen
country: France
facility: Vascular and general neurology
city: Saint-Brieuc
country: France
facility: Neurology
city: Saint-Denis
country: France
facility: Neurology
city: Saint-Malo
country: France
facility: Neurology
city: Saint-Nazaire
country: France
facility: Neurologie
city: Saint-Étienne
country: France
facility: Neurology
city: Strasbourg
country: France
facility: Neurologie
city: Strasbourg
country: France
facility: Neurology
city: Suresnes
country: France
facility: Neurology
city: Toulon
country: France
facility: Neurology
city: Toulon
country: France
facility: Neurology
city: Tours
country: France
facility: Neurologie
city: Valenciennes
country: France
facility: Neurology
city: Vannes
country: France
facility: Neurology
city: Versailles
country: France
facility: Neurology
city: Épinal
country: France
facility: Neurology
Study officials:
References: