louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05775770: Blood Glucose Management in Intensive Care Units
Official title: Survey of Practices on the Management of Glycemia in Patients Hospitalized in Intensive Care Units
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Insulin Hypoglycemia
Glucose Test Site Bleeding
Hyperglycemia
Keywords: glucose control
insulin
Lead sponsor: French Society for Intensive Care
Sponsor class: OTHER
First posted: 2023-03-20
Enrollment: 525
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All adult patients admitted to intensive care or intensive care.

Brief summary: The investigators propose to conduct a study of practices to describe the methods of managing glycemic control in hospitalized patients in critical care. This is a prospective multicenter observational study conducted in Intensive Medicine and Resuscitation departments in France and Belgium. The aim of this study is to carry out an inventory of the current practices of glycemia management as well as their modalities. Being one of the key points of the management, this work will have for main objective to raise the importance of the glycemic variabilities according to the methods of insulin therapies used.


Eligibility criteria: Inclusion Criteria:

* Patient with hyperglycaemia requiring an insulin prescription within 48 hours of admission
* Insulin therapy started less than 12 hours before inclusion of the patient in the study
* Expected duration of hospitalization greater than or equal to 48 hours

Exclusion Criteria:

* Moribund patients
* Patients admitted for ketoacidosis or hyperosmolar coma
* Patients admitted for symptomatic hypoglycaemia
* Patient requiring insulin for serum potassium correction
* Severe acute hepatocellular insufficiency
* Age \< 18 years old
* Pregnant or breastfeeding women
* Patients under legal protection measures

Primary outcomes:
measure: glycemic variability
timeFrame: 48 hours
Secondary outcomes:
measure: adverse outcomes
timeFrame: 48 hours
measure: Analysis of nursing workload
timeFrame: 48 hours
Other outcomes:
Locations:
city: Caen
country: France
facility: CHU Caen
Study officials:
affiliation: French Society for Intensive Care
name: Laurent Papazian
role: STUDY_DIRECTOR
References:
Clinical trial NCT06909370: Peer Education on HPV: Impact on Health Sciences Students' Knowledge, Awareness, and Concern
Official title: The Effect of Peer Education for Human Papilloma Virus (HPV) on Knowledge, Awareness and Concern Levels of Students in the Faculty of Health Sciences
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Human Papilloma Virus (HPV)
Keywords: HPV
peer education
awareness
Lead sponsor: Saglik Bilimleri Universitesi
Sponsor class: OTHER
First posted: 2025-04-03
Enrollment: 127
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: According to the World Health Organization (WHO), 400 million treatable sexually transmitted diseases (STDs) such as syphilis, chlamydia and human papillomavirus (HPV) occur each year in people aged 15-49, mostly in developing countries. As HPV is a sexually transmitted virus, it has been shown to be the most important aetiological factor in cervical cancer in women (99.7%). Vaccination and education of young people about sexuality and STDs are very important in the prevention of HPV. In this respect, the aim of this study was to find out the level of knowledge, concern and awareness of HPV infection among university students and to increase their awareness by informing them about the subject through their peers. The study was conducted as a pre-test and post-test one-group study. The sample of the study consisted of all final year students of Physiotherapy and Rehabilitation (85 students), Nutrition and Dietetics (60 students), Audiology (35 students), Child Development (80 students), Health Management (44 students) and Social Work (45 students) studying in the spring semester of the 2023-2024 academic year. The students were trained by the Gynaecology Nursing Intern student group (9 students) of the Department of Nursing. Data were collected using the Sociodemographic Characteristics Form, the HPV Knowledge Scale and the Human Papilloma Virus Awareness and Concern Level Scale (HPV-FAS). The relevant forms and the consent form were completed by the students before, after and one month after the training.


Eligibility criteria: Inclusion Criteria:

* All individuals who are senior students in the Faculty of Health Sciences departments and who agree to participate in the study will be included in the study.

Exclusion Criteria:

* Individuals who did not complete the study and did not speak and understand Turkish were excluded from the study.

Primary outcomes:
measure: Sociodemographic Characteristics Form
timeFrame: Through study completion, an average of 6 months
measure: HPV Knowledge Scale (HPV-KS)
timeFrame: Through study completion, an average of 6 months
measure: Human Papillomavirus Awareness and Concern Scale (HPV-ACS)
timeFrame: Through study completion, an average of 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: İstanbul
country: Turkey
facility: Istanbul Aydın University
state: Türkiye
Study officials:
References:
Clinical trial NCT04218942: Rocamed Urethral Device (RUD) and Urinary Retention in Males
Official title: Interest of Rocamed Urethral Device for Treatment of Acute or Chronic Urinary Retention in Males
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Urinary Retention
Keywords: Urethral Device
Foley catheterization
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2020-01-06
Enrollment: 15
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Prospective non randomized study of the feasibility of the insertion of Rocamed urethral device by hand manipulation, i.e., without use of cystoscopy, sonography or fluoroscopy. Patients with an acute urinary retention treated by Foley catheterization in the Emergency department have a few days later a trial of Foley removal in the ambulatory unit of the Urology department. In case of failure of the Foley removal trial, i.e., recurrence of urinary retention, patients will be proposed either the insertion of a new Foley or insertion of the urethral device. After signature of an informed consent, insertion of the urethral device will be performed after instillation in the urethra of a local anesthetic gel. Device insertion success rate and complications will be studied. The device will be left in place for one month. Tolerance and complications during the month with the device in place will be studied. At one month the device will be removed: the ease of retrieval of the device and complications will be studied. Patient and doctor satisfaction with the urethral device will be compared to patient and doctor satisfaction with the Foley.


Eligibility criteria: Inclusion Criteria:

* Male \> 18 years old
* Acute retention treated by Foley
* Failure of Foley removal trial
* Clear urine
* No urinary infection
* Efficient striated sphincter

Exclusion Criteria:

* Urethral stenosis
* Hematuria macroscopic
* Urinary infection
* Anticoagulant treatment
* Lidocaine allergy

Primary outcomes:
measure: Percentage of patients in whom the device will be inserted only by hand manipulation
timeFrame: Day 0
Secondary outcomes:
measure: Patient tolerance during device insertion: analogic visual scale 0-10 (0 : no pain / 10 : worst pain imaginable)
timeFrame: Day 0 (Day of device insertion)
measure: Patient tolerance during one month: analogic visual scale 0-10 (0 : excellent tolerance / 10 : intolerable)
timeFrame: 1 Month
measure: Flowmetry with device in place ml/sec
timeFrame: Day 0 (Day of device insertion)
measure: Patient tolerance during retrieval of the device : analogic visual scale 0-10 (0 : no pain / 10 : worst pain imaginable)
timeFrame: 1 month
Other outcomes:
Locations:
city: Pierre-Bénite
country: France
facility: Service d'Urologie Hôpital Lyon Sud, Hospices Civils de Lyon
Study officials:
References:
Clinical trial NCT00273442: Assessing Cosopt Switch Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Ocular Hypertension
Open-Angle Glaucoma
Exfoliation Syndrome
Glaucoma, Pigmentary
Lead sponsor: Pharmaceutical Research Network
Sponsor class: OTHER
First posted: 2006-01-09
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: To assess the safety and efficacy of a cohort of patients switched to the dorzolamide/timolol maleate fixed combination because they are insufficiently controlled on latanoprost monotherapy.


Eligibility criteria: Inclusion Criteria:

* adults with clinical diagnosis of POAG, pigment-dispersion or exfoliation glaucoma or ocular hypertension
* the IOP on latanoprost must be 31 mm Hg or less in both eyes, and 21 to 31 mm Hg inclusive in at least one eye at 08:00 AM
* visual acuity should be 20/200 or better in each eye

Exclusion Criteria:

* contraindications to study drugs
* anticipated change in systemic hypotensive therapy during the trial
* use of any corticosteroids by any route in the three months immediately prior to Visit 2

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Little Rock
country: United States
facility: Little Rock Eye Clinic
state: Arkansas
city: Atlanta
country: United States
facility: Omni Eye Services
state: Georgia
city: Bourbonnais
country: United States
facility: Midwest Eye Center
state: Illinois
city: Tulsa
country: United States
facility: Mark J. Weiss, MD
state: Oklahoma
city: Mt. Pleasant
country: United States
facility: Glaucoma Consultants & Center for Eye Research
state: South Carolina
Study officials:
affiliation: Pharmaceutical Research Network, LLC
name: William C. Stewart, MD
role: STUDY_DIRECTOR
name: Mark J. Weiss, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Omni Eye Services
name: Douglas G. Day, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Midwest Eye Center
name: Sriram Sonty, MD, FACS
role: PRINCIPAL_INVESTIGATOR
affiliation: Little Rock Eye Clinic
name: J. Charles Henry, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Glaucoma Consultants & Center for Eye Research
name: Elizabeth D. Sharpe, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06235242: GT201 Injection in Combination with Teraplizumab Injection for Treatment of Patients with Non-small Cell Lung Cancer
Official title: A Single-arm Clinical Study of Autologous Tumor-Infiltrating Lymphocyte (GT201 Injection ) in Combination with Teraplizumab Injection for Treatment of Patients with Non-small Cell Lung Cancer
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Adult
Non-small Cell Lung Cancer
Keywords: GT201
Lead sponsor: Grit Biotechnology
Sponsor class: INDUSTRY
First posted: 2024-01-31
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This study is a single arm, open design aimed at evaluating the safety and tolerability of Autologous Tumor-Infiltrating Lymphocyte (GT201 injection ) in combination with teraplizumab injection for treatment of patients with non-small cell lung cancer,while evaluating pharmacokinetic characteristics and efficacy assessment to determine the optimal biological dose (OBD).


Eligibility criteria: Inclusion Criteria:

* 1. Voluntarily join the study, signed informed consent form,, willing and able to comply with the study protocol;
* 2. Age 18 to 70 years old;
* 3. Eastern Cooperative Oncology Group (ECOG) performance status score of 0 or 1;
* 4. Expected survival time of ≥ 12 weeks;
* 5. Good function of vital organs;
* 6. Subjects entering this study due to disease progression must have an imaging record of disease progression before tumor sampling;
* 7. At least one measurable target lesion that meets the definition of RECIST v1.1 after tumor sampling.

Exclusion Criteria:

* 1.Patients with uncontrollable tumor-related pain as judged by the investigator; participants requiring analgesic medication must already have a stable analgesic regimen at the time of study entry; symptomatic lesions suitable for palliative radiotherapy should be completed prior to study entry;
* 2.Known mental illness, alcoholism, drug use or substance abuse;
* 3.Pregnant or lactating women; or women who are pregnant, breastfeeding, or planning to become pregnant within 1 year after cell infusion;
* 4.Those who have received other clinical trial drug treatment within 4 weeks before preconditioning by lymphodepletion,plan to participate in other clinical trial drug treatment during the study;
* 5.The investigators determine that other conditions that make the patient not suitable for enrollment.

Primary outcomes:
measure: Safety Profile Measured by Grade ≥3 TRAEs
timeFrame: 3 years
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: Beijing Gobroad Hospital
state: Beijing
city: Shanghai
country: China
facility: Shanghai East Hospital
state: Shanghai
city: Shanghai
country: China
facility: Shanghai GoBroad Cancer Hospital
state: Shanghai
Study officials:
References:
Clinical trial NCT06796842: Effects of Ballistic vs Plyometric Training on Performance of Badminton Players
Official title: Effects of Ballistic vs Plyometric Training on Performance of Badminton Players
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Sports Physical Therapy
Keywords: badminton
performance
ballistic
plyometrics
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2025-01-28
Enrollment: 60
Sex: MALE
Minimum age (years): 20
Maximum age (years): 28
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Ballistic and plyometric training are both frequently utilized to enhance physical performance in a variety of sporting activities that require the ability to jump, sprint, and change direction. both are designed to improve explosive power, but they differ in their approaches and focus. Although many studies highlight the significance of both plyometric and ballistic exercises in enhancing athletic performance in badminton players no direct comparison has been made between the two.

In this study we compared the effectiveness of Ballistic exercises versus Plyometric exercises on performance in Badminton players, which is going to help us to select the best possible training program for badminton athletes

Detailed description: Ballistic and plyometric training are both frequently utilized to enhance physical performance in a variety of sporting activities that require the ability to jump, sprint, and change direction. both are designed to improve explosive power, but they differ in their approaches and focus. Although many studies highlight the significance of both plyometric and ballistic exercises in enhancing athletic performance in badminton players no direct comparison has been made between the two.

In this study we compared the effectiveness of Ballistic exercises versus Plyometric exercises on performance in Badminton players, which is going to help us to select the best possible training program for badminton athletes

Eligibility criteria: Inclusion Criteria

* Active Badminton player.
* Age between 20-28 years.
* Male Badminton players

Exclusion Criteria

* Athletes with injuries, trauma, pathology, any neurological or psychological complications.
* Athletes with Metabolic diseases.
* Age above 28 years or less than 20.
* Other than male Players.

Primary outcomes:
measure: Push up test
timeFrame: six weeks
measure: Closed kinetic chain upper extremity stability test
timeFrame: six weeks
measure: Seated medicine ball throw test
timeFrame: six weeks
measure: Unilateral single arm shot put test
timeFrame: six weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Rawalpindi
country: Pakistan
facility: Liaqat Bagh Stadium Rawalpindi
state: Punjab
Study officials:
affiliation: Riphah International University
name: Dr Nadia Ishtiaq, MS
role: STUDY_DIRECTOR
References:
Clinical trial NCT05057442: The Effects of Remnant-Preserving Anterior Cruciate Ligament Reconstruction on Proprioception and Functionality
Official title: The Effects of Remnant-Preserving Anterior Cruciate Ligament Reconstruction on Proprioception and Functionality
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Anterior Cruciate Ligament Rupture
Lead sponsor: Acibadem University
Sponsor class: OTHER
Collaborators: name: Marmara University
First posted: 2021-09-27
Enrollment: 65
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who were underwent remnant-preserving anterior cruciate ligament reconstruction

Brief summary: Anterior cruciate ligament (ACL) reconstruction is a frequently performed surgical procedure to stabilize the knee joint biomechanically. At the same time, one of the goals is to improve clinical outcomes and return the patient to their daily life as early and ready as possible, as well as to sports activities. Remnant-preserving anterior cruciate ligament reconstruction is one of the reconstruction approaches that aim to achieve these goals earlier and more safely than the standard surgical procedure. However, there is no consensus in the literature regarding the effects of remnant-preserving ACL reconstruction on clinical outcomes and its superiority over the standard surgical procedure. Therefore, the aim of our study is to compare the proprioception and functionality of patients who underwent ACL reconstruction with the remnant-preserving approach, by classifying them according to stump size.


Eligibility criteria: Inclusion Criteria:

* Aged between 18 - 45 years,
* Anatomical single-bundle ACL reconstruction with antero-medial portal technique using hamstring autograft due to a full-thickness ACL tear,
* Endobutton technique was used for femoral fixation,
* Has not had any trauma or surgery on the non-operated knee,
* Patients with a follow-up period of at least 12 months after surgery.

Exclusion Criteria:

* Fracture of lower extremity, posterior cruciate ligament, inner and outer lateral ligament tears accompanying anterior cruciate ligament tear,
* Patients who have undergone previous surgery on the targeted knee,
* Have a revision anterior cruciate ligament reconstruction,
* Having a history of knee joint arthritis (osteoarthritis, inflammatory arthritis),
* Have a neurological disease,

Primary outcomes:
measure: Proprioception assessment
timeFrame: 1 day
measure: The Lysholm Score
timeFrame: 1 day
measure: Single Leg Hop Test
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Marmara University Department of Physiotherapy and Rehabilitation
Study officials:
References:
Clinical trial NCT02067442: Prospective, Randomized, Double Blind Study Comparing IV vs PO Acetaminophen in Patients Undergoing Lumbar Discectomy
Official title: Prospective, Randomized, Double-blind, Placebo-Controlled Study to Compare the Effects of Intravenous Versus Oral Acetaminophen on Postoperative Clinical Outcomes After Ambulatory Lumbar Discectomy
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Pain
Keywords: acetaminophen intravenous oral pain scores opioids
Lead sponsor: Thomas Jefferson University
Sponsor class: OTHER
First posted: 2014-02-20
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Both intravenous and oral acetaminophen have been shown to reduce post-operative pain scores when given preoperatively. This study investigates if there is a difference between the intravenous and the oral forms when given preoperatively to patients undergoing lumbar microdiscectomy. We hypothesize that the intravenous formulation does not improve pain scores or decrease opioid consumption during the first postoperative day compared to the oral formulation.


Eligibility criteria: Inclusion Criteria:

* Single level lumbar micro disk surgery
* Ages 18-65

Exclusion Criteria

* morbid obesity
* prior back surgery
* opioid tolerance
* pregnancy

Primary outcomes:
measure: Postoperative pain scores
timeFrame: Day of surgery
Secondary outcomes:
measure: Quantity of intraoperative and postoperative opioids administered.
timeFrame: Day of surgery
Other outcomes:
Locations:
city: Philadelphia
country: United States
facility: Thomas Jefferson University Hopsital
state: Pennsylvania
Study officials:
References:
Clinical trial NCT00760942: Liquid Preterm Formula Versus Powdered Human Milk Fortifier in VLBW Infants
Official title: Randomized Study of a Liquid High-Calorie Preterm Formula Versus Powdered Human Milk Fortifier in Very-Low Birthweight Infants
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Infant, Very Low Birth Weight
Keywords: Low birth weight
neonates
premature infants
nutrition
human milk fortification
Infant
Lead sponsor: University of Oklahoma
Sponsor class: OTHER
First posted: 2008-09-26
Enrollment: 84
Sex: ALL
Minimum age (years): 1
Maximum age (years): 10
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: This study aims to compare the short-term effects on growth and feeding tolerance of a liquid high calorie formula added to human milk versus powdered human milk fortifier in small preterm infants.


Eligibility criteria: Inclusion Criteria:

* Infants between 500 and 1499 grams of birthweight, receiving mother's milk.

Exclusion Criteria:

* Infants with major congenital anomalies and previous history of gastrointestinal disease.

Primary outcomes:
measure: The primary outcome will be weight gain in g/kg/d over the observation period. Body weight will be measured daily.
timeFrame: 2 - 6 weeks
Secondary outcomes:
measure: Hospital stay and feeding intolerance
timeFrame: 2-6 weeks
Other outcomes:
Locations:
city: Oklahoma City
country: United States
facility: Neonatal Intensive Care Unit/Children's Hospital
state: Oklahoma
Study officials:
affiliation: University of Oklahoma
name: Andrea Willeitner, M.D.
role: PRINCIPAL_INVESTIGATOR
References: