Clinical trial NCT05060211: Incontinence and MRI Results in Children with Cerebral Palsy
Official title: Correlation Between Brain Lesion and Continence in Children with Cerebral Palsy: an Anatomical MRI Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cerebral Palsy
Lower Urinary Tract Symptoms
Keywords: cerebral palsy
lower urinary tract symptoms
Magnetic resonance imaging
brain lesion
incontinence
Lead sponsor: University Hospital, Ghent
Sponsor class: OTHER
Collaborators: name: University Ghent
First posted: 2021-09-29
Enrollment: 125
Sex: ALL
Minimum age (years): 5
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Children with cerebral palsy attending yearly or half yearly follow-up consultation

Brief summary: More than 50 % of children and adults with cerebral palsy experience lower urinary tract symptoms (LUTS). This can negatively influence quality of life of the child and the total social environment.

Previous research demonstrated that the brain lesion, characteristic for cerebral palsy (CP), is a prognostic factor for the functional abilities of a child with CP. Previous research within our department demonstrated functional impairment as a risk factor for incontinence. This demonstrates an indirect connection between the brain lesion and incontinence of a child with CP. However, this connection isn't alway correct as some children with high functionality also demonstrate incontinence.

As bladder control is also regulated by higher brain centers, the present study wants to investigate a direct connection between the brain lesion of the child, visible by means of MRI, and the incontinence status of the child. .

Detailed description: The current study is a cross-sectional observational study in which a correlation is investigated between known anatomical MRI results and the continence status of a child with CP.

Although neuroimaging isn't seen as a requirement for the definition and diagnosis of CP2, MRI imaging is often part of diagnostic evaluation. The Surveillance of Cerebral Palsy in Europe (SCPE) working group composed the MRI classification system or MRICS classifying neuroimaging results in maldevelopments, predominant white matter injury, predominant grey matter injury, miscellaneous and normal. These results will be correlated with results of the validated Vancouver symptoms score for dysfunctional elimination syndrome.

Eligibility criteria: Inclusion Criteria:

* Diagnosis of cerebral palsy
* MRI investigation in history
* Dutch or French speaking child and parent

Exclusion Criteria:

* No MRI investigation in history
* Child or parent not speaking Dutch or French

Primary outcomes:
measure: Incontinence ratio
timeFrame: During cross-sectional testing
Secondary outcomes:
measure: Amount of Lower urinary tract symptoms in different MRICS-groups
timeFrame: During cross-sectional testing
measure: Amount of bladder symptoms in different MRICS-groups
timeFrame: During cross-sectional testing
Other outcomes:
Locations:
city: Ghent
country: Belgium
facility: Ghent University Hospital
state: Flanders
Study officials:
affiliation: Ghent University Hospital/Ghent University
name: Bieke Samijn, dr.
role: PRINCIPAL_INVESTIGATOR
References: