louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02267759: McGrath Videolaryngoscopy for Nasotracheal Intubation
Official title: A Comparison of McGrath Videolaryngoscopy and Macintosh Laryngoscopy for Routine Nasotracheal Intubation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Nasotracheal Intubation
Lead sponsor: Ajou University School of Medicine
Sponsor class: OTHER
First posted: 2014-10-17
Enrollment: 70
Sex: ALL
Minimum age (years): 20
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: McGrath videolaryngoscopy avoids the use of Magill forceps for nasotracheal intubation, thereby reducing intubation time and complications, especially in patients with a difficult airway. This study was performed to investigate whether McGrath videolaryngoscopy is superior to Macintosh laryngoscopy for routine nasotracheal intubation in expected normal airways, as judged by the time to intubation and ease of intubation.


Eligibility criteria: Inclusion Criteria:

* patients for dental or maxillofacial surgery requiring nasotracheal intubation

Exclusion Criteria:

* known difficult airway
* required rapid sequence induction
* history of bleeding
* cervical spine injury

Primary outcomes:
measure: time to intubation
timeFrame: 4 min after anesthetic induction
Secondary outcomes:
Other outcomes:
Locations:
city: Suwon
country: Korea, Republic of
facility: Ajou University Hospital
state: Gyeongki-do
Study officials:
affiliation: Ajou University School of Medicine
name: Jong Yeop Kim, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05070559: Active Release Technique and Graston Technique in Patients With Lateral Epicondylitis
Official title: Comparison of Active Release Technique and Graston Technique In Patients With Chronic Lateral Epicondylitis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Lateral Epicondylitis
Keywords: lateral Epicondylitis
Graston Technique
Active Release Technique
Grip Strength
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2021-10-07
Enrollment: 36
Sex: ALL
Minimum age (years): 15
Maximum age (years): 40
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will be a randomized control trial and will be conducted in Pakistan Railway Hospital Rawalpindi. A sample of 36 participants will be taken. Patients will be divided into two groups by sealed envelop method. Patients in group A will receive Active Release Technique along with conventional therapy while Patients in group B will receive instrument assisted soft tissue mobilization along with conventional therapy. The study includes intervention protocol of 4 weeks. The sessions will be given 3 times a week for 4 weeks. The outcome measures Numeric pain rating scale(NPRS), Hand Dynamometer and Patient-Rated Tennis Elbow Evaluation (PRTEE) will be measured at baseline and at the end of 4th week. Data will be analyzed by SPSS 25

Detailed description: Lateral epicondylitis is an injury caused by overusing the elbow. It is characterized by tenderness and pain over the lateral epicondyle of the elbow. It is not exactly a condition involving inflammation rather a chronic degeneration of the tendon. The major symptom of lateral epicondylitis is presentation or complaint of sharp pain at the lateral side of the elbow with swelling

Eligibility criteria: Inclusion Criteria:

* Chronic lateral epicondylitis, complaints for at least 3 months or more
* Pain intensity level between 3 to 6 on 0-10 point numerical pain rating scale

Exclusion Criteria:

* Acute/ sub-acute lateral epicondylitis
* Any cervical spine or any other upper limb dysfunction
* Any other neurological disease, cardiovascular disease, osteoporosis
* Bilateral complaints

Primary outcomes:
measure: Numeric Pain Rating Scale
timeFrame: 4 Weeks
measure: Hand Dynamometer
timeFrame: 4 Weeks
measure: Patient-Rated Tennis Elbow Evaluation
timeFrame: 4 Weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Rawalpindi
country: Pakistan
facility: Rawal General Hospital Rawalpindi
state: Punjab
Study officials:
affiliation: Riphah International University
name: Sajjad Ali, Ms-OMPT
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00477659: Neural Correlates In Mild Alzheimer's Disease
Official title: A Single Center Study To Examine Neural Correlates Of Cognition In Subjects With Mild Alzheimer's Disease After Three Months Of Open Label Donepezil HCl (Aricept® ) Treatment
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Alzheimer's Disease
Keywords: Functional magnetic resonance imaging examination
Alzheimer's Disease
Donepezil hydrochloride
Aricept
Lead sponsor: Eisai Inc.
Sponsor class: INDUSTRY
Collaborators: name: Pfizer
First posted: 2007-05-24
Enrollment: 14
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The objective of this study was to identify neural correlates of cognitive improvement after 3 months of donepezil hydrochloride treatment using either or both of two functional magnetic resonance imaging (fMRI) measures - the functional Hippocampus Connectivity Index (HCI) and Cerebral Blood Flow (CBF) Perfusion; in the Medial Temporal Lobe (MTL) network in subjects in the early stage of Alzheimer's Disease (AD).


Eligibility criteria: Inclusion Criteria:

* Men and women, aged 50 and older with mild Alzheimer's disease (MMSE scores of 20 to 30 are allowed).
* Diagnostic evidence of Alzheimer's disease.
* Previous use of cholinesterase inhibitors (other than Aricept) and memantine allowed.

Exclusion Criteria:

* Prior use of Aricept, pacemakers and insulin dependent diabetes are not allowed.

Primary outcomes:
measure: Percent Change From Baseline to Week 12 Based on Hippocampus Connectivity Index (HCI)
timeFrame: Week 12
Secondary outcomes:
measure: Change From Baseline at Week 12 in Alzheimer's Disease Assessment Scale - Cognitive Scale (ADAS)-Cog Score
timeFrame: Baseline and Week 12
measure: Change From Baseline at Week 12 in Mini-Mental State Examination (MMSE) Score
timeFrame: Baseline and Week 12
measure: Change From Baseline at Week 12 in the Instrumental Activities of Daily Living (IADL) Assessment Score
timeFrame: Baseline and Week 12
measure: Change From Baseline at Week 12 in the Neuropsychiatric Inventory (NPI) Score
timeFrame: Baseline and Week 12
Other outcomes:
Locations:
city: Milwaukee
country: United States
facility: Medical College of Wisconsin
state: Wisconsin
Study officials:
affiliation: Pfizer
name: Pfizer CT.gov Call Center
role: STUDY_DIRECTOR
References:
Clinical trial NCT06339359: A Pilot Study to Develop a Behavior-based Screening Protocol for Early Diagnosis of Autism Spectrum Disorders
Official title: A Pilot Study to Develop a Behavior-based Screening Protocol for Early Diagnosis of Autism Spectrum Disorders
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: ASD
Lead sponsor: Bundang CHA Hospital
Sponsor class: OTHER
First posted: 2024-04-01
Enrollment: 200
Sex: ALL
Maximum age (years): 19
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Children and adolescents volunteers

Brief summary: This study aims to collect basic data to develop a tool for early screening of autism spectrum disorder (ASD) in children and adolescents through eye tracking and motion analysis.

Detailed description: This study aims to collect basic data to develop a tool for early screening of autism spectrum disorder (ASD) in children and adolescents through eye tracking and motion analysis.

Eligibility criteria: Inclusion Criteria:

* Children and adolescents under the age of 19 at the time of registration
* A person whose legal representative voluntarily decides to participate and agrees in writing to comply with the precautions after receiving a detailed explanation of this study and fully understanding it

Exclusion Criteria:

* Those with abnormalities in hearing and vision
* Those who are likely to have difficulty participating in the study according to the judgment of the clinical investigator
* If the visits set out in this research plan are not followed or the patient's guardian does not cooperate due to low understanding of the patient.

Primary outcomes:
measure: K-BSID-Ⅲ
timeFrame: Between March 2024 and March 2025
measure: ADI-R
timeFrame: Between March 2024 and March 2025
measure: M-CHAT
timeFrame: Between March 2024 and March 2025
measure: ADOS-2
timeFrame: Between March 2024 and March 2025
measure: K-WPPSI-Ⅳ
timeFrame: Between March 2024 and March 2025
measure: K-CARS-2
timeFrame: Between March 2024 and March 2025
measure: CBCL
timeFrame: Between March 2024 and March 2025
measure: SCQ
timeFrame: Between March 2024 and March 2025
measure: GMFM
timeFrame: Between March 2024 and March 2025
measure: HFT
timeFrame: Between March 2024 and March 2025
measure: BOT-2
timeFrame: Between March 2024 and March 2025
measure: VMI-6
timeFrame: Between March 2024 and March 2025
measure: SP
timeFrame: Between March 2024 and March 2025
measure: Eye Tracking
timeFrame: Between March 2024 and March 2025
measure: Motion Analysis
timeFrame: Between March 2024 and March 2025
Secondary outcomes:
Other outcomes:
Locations:
city: Seongnam-si
country: Korea, Republic of
facility: CHA Bundang Medical Center, CHA University
state: Gyeonggi-do
Study officials:
References:
Clinical trial NCT04778059: Safety and Efficacy of USB002 for Respiratory Distress Due to COVID-19
Official title: Phase 2 Trial to Evaluate the Safety, Tolerability, and Preliminary Efficacy of Intravenous USB002 to Treat Patients With Respiratory Distress Due to COVID-19 Infection
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE2
Conditions: 2019 Novel Coronavirus Infection
COVID-19 Virus Infection
SARS Coronavirus 2 Infection
SARS-CoV-2 Infection
Respiratory Distress Syndrome, Adult
Adult Respiratory Distress Syndrome
Lead sponsor: US Biotest, Inc.
Sponsor class: INDUSTRY
First posted: 2021-03-02
Enrollment: 21
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This trial will study the use of USB002 given as an intravenous infusion in patients with respiratory distress due to infection with COVID-19.


Eligibility criteria: Inclusion Criteria:

1. Signed informed consent from patient or legal representative;
2. Age 18 or greater;
3. Positive reverse transcription polymerase chain reaction (RT-PCR) for SARS-CoV-2 (≤10 days);
4. Respiratory rate \> 20 RR;
5. SpO2 \< 94% on room air, requiring supplemental oxygen, requiring invasive mechanical ventilation, or requiring ECMO;
6. Chest X-ray confirming bilateral pulmonary infiltrates;
7. Body mass index of ≤ 40 units/kg/m2;
8. Adequate method of birth control.

Exclusion Criteria:

1. Terminally ill patients due to underlying cardiac, cancer or severe debilitating neurological disease including coma;
2. Hospitalization expected to be \< 96 hours due to medical improvement;
3. Interstitial lung disease;
4. Correction of QTc values obtained by 12 lead EKG using Fredericia's formula (QTcF) \> 450 ms;
5. History of hypotension (mean arterial blood pressure \< 65 mmHg), unrelated to CoVID-19 infection;
6. Alanine aminotransferase (ALT) or aspartate aminotransferase (AST) \> 3 times upper limit of normal;
7. Participating concurrently on another clinical trial for the experimental treatment of COVID-19;
8. Active chemotherapy use;
9. Pregnant and/or lactating women.

Primary outcomes:
measure: Number of Participants With Treatment Emergent Adverse Events (TEAE)
timeFrame: Day 1 to Day 70 (or date of final measurement, if sooner)
Secondary outcomes:
Other outcomes:
Locations:
city: Tucson
country: United States
facility: The University of Arizona Health Sciences Center/ Banner Healthcare Systems Hospitals
state: Arizona
Study officials:
affiliation: The University of Arizona Health Sciences Center/ Banner Healthcare Systems Hospitals
name: Sairam Parthasarathy, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00651170: Diffusion of Local Anesthetic After Median Nerve Block
Official title: Can Ultrasound Predict Success of Median Nerve Block? Relationship Between Diffusion of Local Anesthetic and Effectiveness of a Nerve Block
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Median Nerve
Keywords: Median block nerve
Ultrasound
Lead sponsor: Hopital Foch
Sponsor class: OTHER
First posted: 2008-04-02
Enrollment: 103
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: primary care clinic

Brief summary: Median nerve block is widely practised, avoiding general anaesthesia in a number of cases and producing excellent post-operative analgesia in orthopedic surgery. Even realised by experienced anaesthetists,a failure rate of 5-15% is noticed. The principal aim of the study is to observe the local anesthetic solution diffusion after a conventional median nerve block technique using neurostimulation. The secondary objective is to compare diffusion and of block efficacy..


Eligibility criteria: Inclusion Criteria:

* Patients undergoing elective hand surgery requiring a median block nerve.

Exclusion Criteria:

* age lower than 18 years
* pregnancy
* contraindication to nerve block
* inability to read, write or speak French
* mental illness.

Primary outcomes:
measure: Anesthesic diffusion degree
timeFrame: 1 hour
Secondary outcomes:
Other outcomes:
Locations:
city: Suresnes
country: France
facility: Hôpital Foch
city: Trappes
country: France
facility: Hôpital privé de l'Ouest Parisien
Study officials:
affiliation: Hopital Foch
name: Marc Fischler
role: STUDY_CHAIR
References:
Clinical trial NCT04686370: Effect of Different Implant Surface Treatments on Bony Changes Around Mandibular Implants
Official title: Effect of Different Implant Surface Treatments on Bony Changes Around Mandibular Implants for Completely Edentulous Patients (A Split-mouth Comparative Study)
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Complete Edentulism
Keywords: Dental implant
Surface treatment
Laser
Sandblasted Acid-etched implants
Delayed-loading
Bony changes
Marginal bone loss
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2020-12-28
Enrollment: 13
Sex: ALL
Minimum age (years): 35
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: one single group will receive both types of dental implants (Split-mouth)
Primary purpose: PREVENTION

Brief summary: The research will be conducted to report which type of surface treatment of dental implants that can be successful and aids in increasing bone to implant contact and how it affects the bony changes around the implants installed in mandibular arches for completely edentulous patients or whether there are specific precautions to be taken into consideration during implant planning concerned with the type of surface microstructure treatment and recommendations needed.

Detailed description: Primary objective:

PICO P: Completely edentulous patients I: Laser surface treatment of implants C: Sandblasted Acid etched surface treatment O: Bony changes

Each Participants will have 2 implants;one laser surface treated implants and another sandblasted acid-etched implant (split-mouth) installed in the intra-foraminal area of mandibular arch prosthetically driven by the prepared conventional denture. MS and AF are responsible for delayed-loading of the denture and will measure bony changes around laser treated surface implants using radiographic assessment using long paralleling technique periapical digital x-ray(SOREDEX™ DIGORA™ Optime)

Eligibility criteria: Inclusion Criteria:

* Completely edentulous patients
* Angle's class 1 skeletal relationship
* Normal facial asymmetry
* Cooperative patients
* Adequate inter-arch spcae not less than 12mm

Exclusion Criteria:

* Tempromandibular joint disorder
* Uncontrolled diabetes
* Bleeding disorders or anticoagulant therapy
* Flabby tissues or sharp mandibular residual ridge
* Heavy smoker
* Patient's with neuromuscular disorders
* Patients on chemotherapy or radiotherapy
* Severe psychiatric disorders

Primary outcomes:
measure: Marginal bone stability around dental implants
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty of dentistry,cairo university
Study officials:
affiliation: Cairo University
name: Marwan Mohamed, Investigator
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01510470: Clinical and Radiological Outcomes Study on Astra Tech Osseospeed Tx Profile Implant
Official title: Clinical and Radiological Outcomes Study on Astra Tech Osseospeed Tx Profile Implant
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Malocclusion; Displaced or Missing Teeth
Keywords: AstraTech Osseospeed Profile Implant
Marginal bone level
soft tissue
soft tissue responds
Lead sponsor: Hong Kong Brånemark Osseointegration Center
Sponsor class: OTHER
Collaborators: name: Dentsply Sirona Implants and Consumables
First posted: 2012-01-16
Enrollment: 15
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with single missing maxillary or mandibular premolar or molar

Brief summary: The Astra Tech Osseospeed Profile Implant design when placed in the healed extraction site maintains the marginal bone level


Eligibility criteria: Inclusion Criteria:

* Patients with single missing maxillary or mandibular premolar or molar
* The edentulous sites should be healed sites
* The opposing tooth will be a natural dentition

Exclusion Criteria:

* general contraindications to dental implant surgery
* Patient with irradiation in the head and neck region
* Immuno-suppressed or immuno-compromised patients
* Patients who took or are taking amino-bisphosphonates
* Patients with poor oral hygiene and motivation
* Patients with untreated periodontitis
* Uncontrolled diabetes
* Pregnancy or lactation
* Addiction to alcohol or other drugs
* patients with psychiatric problems
* Lack of occluding dentition/prosthesis
* Restricted mouth opening (less than 3.5cm inter-arch anteriorly)
* Patients with an acute or chronic infection/inflammation in the area intended for implant placement
* Patients unable to commit 5 years follow up
* Patients referred for implant placement only

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Hong Kong SAR
country: China
facility: Hong Kong Brånemark Osseointegration Centre
Study officials:
References:
Clinical trial NCT04547075: In Turkish Version Lumbar Spine Surgery Expectation Survey
Official title: Turkish Validity and Reliability of Lumbar Spine Surgery Expectation Survey
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Lumbar Spinal Stenosis
Lumbar Disc Herniation
Lumbar Radiculopathy
Lumbar Fracture
Patient Satisfaction
Patient Preference
Keywords: patient expectations
lumbar spine surgery
turkish version
validity and reliability
Lead sponsor: Kutahya Health Sciences University
Sponsor class: OTHER
First posted: 2020-09-14
Enrollment: 180
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients at Kutahya Health Sciences University Hospital will be interviewed in person with two questionnaires.

Brief summary: The aim of this study was to determine the Turkish validity and reliability of Lumbar Spine Surgery Expectations Survey developed by Mancuso.

Detailed description: Although success in lumbar spine surgeries depends on many factors, it has been reported that one of the most important of these factors is patient expectations. In order for patients and health professionals to have the same priorities and meet the same realistic goals, it is necessary to understand what patients expect. Lumbar spine surgery expectations scale was created by Mancuso et al. The aim of this study was to determine the Turkish validity and reliability of Lumbar Spine Surgery Expectations Survey developed by Mancuso.

Eligibility criteria: Inclusion Criteria:

* speak Turkish
* arescheduled for lumbar spine surgery by one of two participating spine surgeons

Exclusion Criteria:

* have cognitive deficits
* refuse to participate

Primary outcomes:
measure: Lumbar Spine Surgery Expectation Survey
timeFrame: 10 minutes
measure: Quebeck Back Pain Disability Index
timeFrame: 10 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Kütahya
country: Turkey
facility: Kutahya Health Sciences University
Study officials:
affiliation: Kutahya Health Sciences University
name: Ismail SARACOGLU, Ph.D.
role: STUDY_DIRECTOR
affiliation: Kutahya Health Sciences University
name: Cihan Cihan, Ph.D.
role: PRINCIPAL_INVESTIGATOR
affiliation: Karabuk University
name: Metehan YANA, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References: