Clinical trial NCT02299583: Controlled Trial of Early Intervention With Children and Adolescents Exposed to Nonrelational Traumatic Events
Official title: Protocol for a Controlled Trial of Early Intervention With Children and Adolescents Exposed to Nonrelational Traumatic Events Comparing Trauma-informed and Usual Health Care Practice
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Posttraumatic Stress Disorder
Depression
Anxiety
Keywords: prevention
early intervention
trauma-informed practice
Lead sponsor: Rigshospitalet, Denmark
Sponsor class: OTHER
Collaborators: name: The Egmont Foundation
name: Ramboll Group
First posted: 2014-11-24
Enrollment: 684
Sex: ALL
Minimum age (years): 8
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Background: International studies have shown that a substantial number of children and adolescents are exposed to potentially traumatic events. Many of these children and adolescents, some of whom will experience posttraumatic stress disorder (PTSD), are submitted to health care departments shortly after exposure as the most common types of traumatic events are accidental injury, serious somatic illness or death of someone close. There has been some research on early psychological interventions for prevention and treatment of PTSD. However, very little research has examined the efficacy of trauma-informed practice among health care professionals (HCPs). The present trial aims to evaluate and compare trauma-informed health care with usual practice.

Methods/Design: The primary clinical question under investigation is the efficacy of an early, trauma-informed intervention for the prevention of PTSD in children and adolescents following exposure to a potentially traumatic event. The trail compares a standardized trauma-informed practice with usual care (no intervention) in health care departments receiving children and adolescents after exposure to determine if trauma-informed care is associated with a reduction in psychological outcome measures over time. Specifically, the investigators examine the efficacy of health care professional's active use of trauma-informed standards of action and a trauma training program for HCPs in the intervention group. The primary outcome will be a reduction in trauma, anxiety and depressive symptoms on self-reports in the active intervention compared to usual care.

Discussion: This trial will be the first controlled trial to examine a trauma-informed intervention carried out by HCPs. It will provide the first evidence on the efficacy of health care delivered by trauma-educated HCPs using trauma-informed standards of action. A successful implementation of this protocol will support the thesis that prevention of PTSD among children and adolescents benefits from a focus on the practice of HCPs. If efficacious, the results will be a call for future research to extend the investigation of interventions from psychological treatment to HCP-based care.

Detailed description: Background

A significant number of children and adolescents have been exposed to potentially traumatic events (PTEs). American and Australian studies report a prevalence of about 20-25% of high magnitude traumatic events among adolescents. A Danish study of four Nordic countries found that 90 % of adolescents with a mean age of 14.5 years had been exposed to at least one low magnitude traumatic event.

A potentially traumatic event may be either relational such as sexual or physical abuse or nonrelational such as illness, motor vehicle accident or fire. The incidence of nonrelational trauma is very high in children and adolescents with accidental injuries being the largest cause of morbidity and mortality among children in the United States as well as in Denmark. Although many children and adolescents demonstrate great resilience or appear to be only briefly affected by nonrelational traumatic events a significant minority of young people will develop posttraumatic stress disorder (PTSD), posttraumatic stress symptoms (PTSSs) or other psychological difficulties following exposure to trauma.

Accidental injury is the most common type of trauma. Researchers report prevalence rates of PTSD among children and adolescents in road traffic accidents ranging from 6% to 35%. Rates of PTSSs (also termed subclinical, subthreshold or partial PTSD) range from 11% to 50%6-14. These rates are important since recent research has indicated only minor differences in terms of distress and impairment between children meeting full and partial criteria for PTSD.

The diagnosis of medical illness such as cancer or diabetes has also been shown to cause PTSD in some children and adolescents with prevalence rates of 5.4% for diabetes and of 10% to 18% for cancer. A recent meta-analysis of prevalence related to both injury and illness reported average prevalence rates of PTSD related to injury ranging from 0% to 37.5%, with a mean of 19.82%, and rates in ill youth ranging from 0% to 32%, with a mean of 12.04%.

Preventive interventions for children and adolescents

Given the high prevalence rates of exposure and the likewise high prevalence rates of PTSD and PTSSs after PTEs there is a pressing need for preventive interventions that decrease the risk of PTSD. In a recent systematic review by Forman-Hoffman et al. (2013) of interventions for children exposed to nonrelational traumatic events 6 different interventions based exclusively on exposure were identified. These included trauma-focused cognitive-behavioural therapy child and family traumatic stress intervention (CFTSI), 2 different school interventions with elements of CBT, early psychological intervention and a propranolol study. The two latter studies found no improvement in outcomes, the remaining 4 interventions found some improvement with regards to PTSD, severity of PTSD and PTSSs.

Another recent meta-analysis by Kramer (2011) reviewing early psychological interventions in children and adolescents after single trauma included seven studies (two of which reappeared in the above mentioned review). These included CFTSI, school-based interventions, early psychological interventions, and two interventions based exclusively on psychoeducational information provision. The authors concluded that intervention effects regarding PTSSs and PTSD were small or non-significant but found promising beneficial tendencies with regards to dissociation, anxiety and, to some extent, arousal.

Overall, the empirical literature has not supported the effectiveness of early psychological interventions such as psychological debriefing and single-session psychological intervention on preventing PTSD and PTSSs in children. These results are consistent with a Cochrane review by Rose 2002 of the effects of psychological debriefing for preventing PTSD in adults. However, school-based and family-focused interventions, as well as stepped-procedure and multiple-session psychological interventions have shown promising results.

In conclusion, the current outcomes of the empirical research suggest early interventions that include the following elements31: age-appropriate psychoeducation, the provision of individual coping skills, parental involvement, social support, risk-assessment, multiple sessions and trauma exposure.

The modest results of early psychological interventions suggest a need for a broader perspective on preventive interventions for children and adolescents exposed to nonrelational trauma. Despite the variety of interventions evaluated by the studies included in the two cited reviews none of the studies focused on the practice of health care professionals. This study is the first to conduct a controlled trial of a standardized preventive intervention conducted by health care professionals. The intervention to be evaluated in this study includes all of the above mentioned empirically supported elements except multiple sessions and trauma exposure.

Trauma-informed health care

The concept of trauma-informed practice has been advocated by institutions and researchers in diverse areas such as psychology, mental health care, education, child welfare, first responders, juvenile justice, and health care. The main aim of trauma-informed practice is to create systematic approaches within these areas to develop evidence-based services that address the impact of trauma on the children they serve37. This study will provide evidence on the impact of the practice of HCPs on symptoms, coping and social functioning of children, adolescents and their families who have been exposed to nonrelational trauma. It investigates the effects of educating HCPs in trauma-informed practice and the effects of a standardized trauma-informed plan of action implemented in health care departments working with children and adolescents.

Design of the trial

This study is designed as a controlled trial with one active intervention and one comparison. The study will be conducted across 19 health care departments in 7 hospitals in the Capitol Region of Denmark. There will be two measurement occasions: one assessment 4 weeks after exposure and one follow-up 6 months after exposure. The trial will run over 18 months. During the first 12 months the intervention will run in 12 of the participating departments while the other 8 departments will function as a control group. During the last 6 months the intervention will run in all nineteen departments thus expanding the sample size of the intervention group. Since the intervention is carried out by health care professionals shortly after exposure, the children in the control group will not receive intervention at any point.

Because the intervention investigated in this trial is conducted by HCPs as an integrated part of their general practice (as opposed to a specific treatment program), it was neither practically possible nor ethically sound to design the allocation of participants in the control and intervention group as a randomization of subjects. For this reason, the allocation was done, not on a subject level, but on the level of departments. This precluded an actual randomization of the trial. However, it should be noted that the allocation of the departments is done before the intervention and thus prior to the recruitment of participants. This means that the allocation of subjects was predetermined in advance of their admission to the hospital. This prevents some of the bias associated with the lack of randomization. In the allocation of departments the best possible match of patient groups was pursued.

It is the hypotheses of this study that: The children and adolescents who receive the intervention, compared to participants in the control group, will demonstrate greater reduction in posttraumatic stress, anxiety and depressive symptoms and higher ratings on positive cognitive coping skills and social functioning.

Sample Size and Power Calculation

Given that this is the first trial to examine the effect of a trauma-informed intervention conducted by HCPs as part of their general health care practice, calculations of power were very limited. Furthermore, effect sizes from related trials such as early psychological interventions and interventions based on information provision have been small or non-significant. Given these limitations, however, calculations of power were conducted on the basis of the available evidence.

Results from a study by Kenardy et al. (2008) on an information-provision intervention had an effect size of 0.63 (between groups) on child anxiety. In a similar study by Cox et al. (2010) effect size on child anxiety was 0.33. Based on the results from Cox et al. (2010) a power analysis revealed that 115 families per group (N = 230) will result in 80% power for detecting a significant difference between the intervention and the control group at the 5% significance level. However, with an estimated 25% attrition rate over the assessment time periods, a total of 290 families should be aimed at to be recruited for the study.

Another power analysis was conducted to calculate the power given a specific sample size. This was done because the participating departments are required to include all eligible families presented to the departments during the intervention period. It was estimated that each department would receive two eligible participants per month. Because of the difference in size between the intervention group and the control this resulted in a sample size of 516 for the intervention group and 168 for the control group (N = 684). With an estimated 25 % attrition rate these numbers amount to 387 for the intervention group and 126 for the control group (N = 513). A post hoc power calculation resulted in 94 % power with an effect size of 0.33 and a 5 % significance level.

Statistical Considerations

Prior to statistical analysis of outcomes, the control group and the intervention group will be compared for pre-intervention equivalence on demographic information and type of PTE. If significant differences are identified, this will be taken into account by including these variables as covariates in outcome analyses. The outcome data will be analysed and reported in terms of statistical significance of difference between intervention and control group in change over time on outcome, clinical significance of the change, and effect sizes. The analysis will be performed by researchers who have not been involved in assessing eligibility of participants, collection of data or entering of data.

Primary analysis will be undertaken on an intention-to-treat (ITT) basis, including all participants who have received intervention or have been registered to the control group, regardless of withdrawal from the study. The data will be analysed with a mixed effects model, which is able to include participants whose data may be partly missing. Analysis of covariance will be conducted with three pairs of outcome: 1) child and parent outcome, 2) symptom outcome and coping outcome, and 3) symptom outcome and social functioning outcome. Other outcomes such as demographics and types of PTE will be described.

Eligibility criteria: Inclusion Criteria:

* Aged between 8 and 18 years
* Admission to hospital for accidental injury involving danger to life, serious injury or impairment
* Admission to hospital for acute illness involving danger to life, serious injury or impairment
* Sudden severe impairment of medical condition
* Admission of parent or sibling to hospital for accidental injury involving danger to life, serious injury or impairment
* Admission of parent or sibling to hospital for acute illness involving danger to life, serious injury or impairment
* Sudden severe impairment of parental or sibling medical condition
* Consent to participate in the study

Exclusion Criteria:

* Parent's Danish insufficient for questionnaire completion
* Developmental delay or mental retardation in the child
* Moderate to severe head injury or posttraumatic amnesia following the accident
* Injury due to physical or sexual abuse (intentional injury)

Primary outcomes:
measure: Severity of posttraumatic stress symptoms (Children's Revised Impact of Event Scale.)
timeFrame: 4 weeks after the traumatic event
measure: Severity of posttraumatic stress symptoms (Children's Revised Impact of Event Scale.)
timeFrame: 6 months after the traumatic event
measure: Change from baseline in severity of posttraumatic stress symptoms at 6 months (Children's Revised Impact of Event Scale.)
timeFrame: 4 weeks and 6 months after the traumatic event
measure: Severity of anxiety symptoms (Revised Child Anxiety and Depression Scale.)
timeFrame: 4 weeks after the traumatic event
measure: Severity of anxiety symptoms (Revised Child Anxiety and Depression Scale.)
timeFrame: 6 months after the traumatic event
measure: Change from baseline in severity of anxiety symptoms at 6 months (Revised Child Anxiety and Depression Scale.)
timeFrame: 4 weeks and 6 months after the traumatic event
measure: Severity of depressive symptoms (Revised Child Anxiety and Depression Scale.)
timeFrame: 4 weeks after the traumatic event
measure: Severity of depressive symptoms (Revised Child Anxiety and Depression Scale.)
timeFrame: 6 months after the traumatic event
measure: Change from baseline in severity of depressive symptoms at 6 months (Revised Child Anxiety and Depression Scale.)
timeFrame: 4 weeks and 6 months after the traumatic event
Secondary outcomes:
measure: Social functioning of the family (Crisis Support Scale and the WHO-Five Well-being Index.)
timeFrame: 4 weeks after the traumatic event
measure: Social functioning of the family (Crisis Support Scale and the WHO-Five Well-being Index.)
timeFrame: 6 months after the traumatic event
measure: Change from baseline in social functioning of the family at 6 months (Crisis Support Scale and the WHO-Five Well-being Index.)
timeFrame: 4 weeks and 6 months after the traumatic event
measure: Cognitive coping skills of the children and their parents ( Post-traumatic Cognitions Inventory.)
timeFrame: 4 weeks after the traumatic event
measure: Cognitive coping skills of the children and their parents ( Post-traumatic Cognitions Inventory.)
timeFrame: 6 months after the traumatic event
measure: Change from baseline in cognitive coping skills of the children and their parents at 6 months ( Post-traumatic Cognitions Inventory.)
timeFrame: 4 weeks and 6 months after the traumatic event
Other outcomes:
measure: The families' satisfaction with the intervention program (Intervention Satisfaction Questionnaire)
timeFrame: 4 weeks after traumatic event
measure: The families' relational coping skills (Relational Coping Questionnaire )
timeFrame: 4 weeks after the traumatic event
measure: The families' relational coping skills (Relational Coping Questionnaire )
timeFrame: 6 months after the traumatic event
measure: Change from baseline in the families' relational coping skills at 6 months (Relational Coping Questionnaire )
timeFrame: 4 weeks and 6 months after the traumatic event
Locations:
city: Copenhagen
country: Denmark
facility: Hospitals of the Capitol Region of Denmark
Study officials:
affiliation: Rigshospitalet, Denmark
name: Lasse P Michelsen, MA
role: PRINCIPAL_INVESTIGATOR
affiliation: Rigshospitalet, Denmark
name: Ditte B Eriksen, LPsy
role: PRINCIPAL_INVESTIGATOR
affiliation: Rigshospitalet, Denmark
name: Carolina M Maier, MSc
role: STUDY_DIRECTOR
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