Clinical trial NCT03985787: Resistance Training and Appetite Regulation
Official title: The Effects of Resistance Training on Appetite Regulation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obesity
Keywords: Resistance Exercise
Appetite Regulation
Lead sponsor: University of Colorado, Denver
Sponsor class: OTHER
Collaborators: name: National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
First posted: 2019-06-14
Enrollment: 23
Sex: ALL
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: This study plans to learn more about how resistance training impacts appetite and the brain's response to food. The study will be evaluating how the brain responds to food images as well as how behaviors and hormones change with a 12 week resistance training intervention.

Detailed description: Aim 1: To determine if RT impacts neuronal function associated with food intake behavior in a manner favoring reduced EI in overweight/obese adults.

Hypothesis: Compared to pre, post-RT fMRI measures will demonstrate ↓ neuronal responses to food cues in the insula, prefrontal cortex, and hypothalamus, brain regions implicated in reward, impulsivity, motivation, and regulation of ingestive behaviors. These changes will be associated with ad libitum EI.

Aim 2: To determine if RT impacts appetite-related peptides, ratings, and food intake behaviors in a manner favoring reduced EI in overweight/obese adults.

Hypothesis: Compared to pre, post-RT measures will show changes in appetite-related peptides, ratings (↓ hunger ↑ satiety), and behaviors (↓food-related cravings \& impulsivity, ↑ self-efficacy) consistent with EI reduction. Changes in appetite regulation indices will be associated with changes in relevant brain networks (Aim 1). These changes will also be associated with ↓ ad libitum EI.

Exploratory Aim: To determine if RT impacts neuronal function and appetite-related peptides and behaviors in a manner favoring ↓ EI in Non-Compensators (top tertile of fat mass loss) as compared to Compensators (bottom tertile of fat mass loss).

Hypothesis: Compared to Compensators, Non-Compensators will show ↓ neuronal responses to food cues and default network, and changes in appetite-related peptides, ratings, and behaviors consistent with ↓ EI.

Eligibility criteria: Inclusion Criteria:

* all ethnic groups
* both sexes
* age: 18-55
* BMI: 27-40 kg/m2
* weight stable (±5% in last 6 months)
* sedentary (\<2 hours of planned physical activity/week by self-report, no RT in previous 12-months)

Exclusion Criteria:

* history of CVD
* DM
* uncontrolled Hypertension
* untreated thyroid disease
* renal disease
* hepatic disease
* other condition affecting weight/metabolism
* unable to exercise
* smoker
* medications affecting weight
* EI or EE in past 6 months
* weight loss/gain \>5% in past 6 months
* post-menopausal women (defined as age appropriate women with 6 months or more of amenorrhea)
* currently pregnant, lactating, \< 6 months post-partum
* woman who have undergone oophorectomy
* bariatric surgery
* major psychiatric disorder
* alcohol or substance abuse
* depression by history and/or score \>21 on CES-D
* history of eating disorders and/or score \>20 on EATS-26

Primary outcomes:
measure: Change in Neuronal Responses to Food Cues in Regions of Interest
timeFrame: Baseline, 12 Weeks
Secondary outcomes:
measure: Change in Whole Brain Response
timeFrame: Baseline, 12 Weeks
measure: Change in Default Mode Network
timeFrame: Baseline, 12 Weeks
measure: Changes in Appetite Ratings
timeFrame: Baseline, 12 Weeks
measure: Changes in Appetite-Related Hormones
timeFrame: Baseline, 12 Weeks
measure: Change in In Lab Ad Libitum Energy Intake (kcals)
timeFrame: Baseline, 12 Weeks
measure: Change in Free-Living Ad libitum Energy Intake (kcals)
timeFrame: Baseline, 12 Weeks
Other outcomes:
measure: Changes in Free-Living Physical Activity and Sedentary Time
timeFrame: Baseline, 12 Weeks
measure: Changes in Muscular Strength
timeFrame: Baseline, 12 Weeks
measure: Change in Body Mass (kg)
timeFrame: Baseline, 12 Weeks
measure: Change in Body Composition
timeFrame: Baseline, 12 Weeks
measure: Change in Neuronal Responses to Food Cues in Regions of Interest by Non-Compensator vs. Compensator groups
timeFrame: Baseline, 12 Weeks
measure: Change in Neuronal Responses to Food Cues in Regions of Interest by Sex
timeFrame: Baseline, 12 Weeks
measure: Change in Whole Brain Response by Non-Compensator vs. Compensator groups
timeFrame: Baseline, 12 Weeks
measure: Change in Whole Brain Response by Sex
timeFrame: Baseline, 12 Weeks
measure: Change in Default Mode Network by Non-Compensator vs. Compensator groups
timeFrame: Baseline, 12 Weeks
measure: Change in Default Mode Network by Sex
timeFrame: Baseline, 12 Weeks
measure: Changes in Appetite Ratings by Non-Compensator vs. Compensator groups
timeFrame: Baseline, 12 Weeks
measure: Changes in Appetite Ratings by Sex
timeFrame: Baseline, 12 Weeks
measure: Changes in Appetite-Related Hormones by Non-Compensator vs. Compensator groups
timeFrame: Baseline, 12 Weeks
measure: Changes in Appetite-Related Hormones by Sex
timeFrame: Baseline, 12 Weeks
measure: Change in In Lab Ad Libitum Energy Intake (kcals) by Non-Compensator vs. Compensator groups
timeFrame: Baseline, 12 Weeks
measure: Change in In Lab Ad Libitum Energy Intake (kcals) by Sex
timeFrame: Baseline, 12 Weeks
measure: Change in Free-Living Ad libitum Energy Intake (kcals) by Non-Compensator vs. Compensator groups
timeFrame: Baseline, 12 Weeks
measure: Change in Free-Living Ad libitum Energy Intake (kcals) by Sex
timeFrame: Baseline, 12 Weeks
measure: Changes in Free-Living Physical Activity and Sedentary Time by Non-Compensator vs. Compensator groups
timeFrame: Baseline, 12 Weeks
measure: Changes in Free-Living Physical Activity and Sedentary Time by Sex
timeFrame: Baseline, 12 Weeks
measure: Change in Muscular Strength by Non-Compensators vs Compensators
timeFrame: Baseline, 12 Weeks
measure: Change in Muscular Strength by Sex
timeFrame: Baseline, 12 Weeks
measure: Change in Body Mass by Non-Compensator vs. Compensator groups
timeFrame: Baseline, 12 Weeks
measure: Change in Body Mass by Sex
timeFrame: Baseline, 12 Weeks
measure: Change in Body Composition by Non-Compensator vs. Compensator groups
timeFrame: Baseline, 12 Weeks
measure: Change in Body Composition by Sex
timeFrame: Baseline, 12 Weeks
Locations:
city: Aurora
country: United States
facility: University of Colorado Denver - Anschutz Medical Campus
state: Colorado
Study officials:
affiliation: University of Colorado, Denver
name: Marc-Andre Cornier, MD
role: PRINCIPAL_INVESTIGATOR
References: