Clinical trial NCT06784271: Effect of Acute Phenylcapsaicin Intake on Trained Cross-Training Athletes
Official title: Effect of Acute Phenylcapsaicin Intake on Trained Cross-Training Athletes: a Randomized, Placebo-Controlled Crossover Study
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Performance
Keywords: Phenylcapsaicin
performance
concurrent exercise
nutrition
recovery
Lead sponsor: Universidad de Granada
Sponsor class: OTHER
Collaborators: name: Universidad de La Laguna, San Cristóbal de La Laguna, Santa Cruz de Tenerife, Spain.
First posted: 2025-01-20
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: OTHER

Brief summary: The aim of this study is to investigate the effect of acute phenylcapsaicin intake during a cross-training session on perceived exertion, performance, and recovery in cross-training athletes.

Detailed description: Capsaicin appears to enhance athletic performance by reducing perceived effort, increasing mechanical performance (e.g., total volume load), and decreasing muscle damage. Given the close relationship between the metabolic and physiological responses of cross-training and supplementation with Phenylcapsaicin (PC), it could be expected that consuming capsaicin during cross-training would have a favorable impact on perceived effort, recovery, and performance.

25 women and 24 men trained in CrossFit consumed either Phenylcapsaicin (PC) or a placebo during a CrossFit class, which consisted of a 16-minute weightlifting segment and a 15-minute WOD. Both the Rating of Perceived Exertion (RPE) and the Perceived Recovery Status scale (RPS) were administered at the beginning of the session and at the end of each segment of the CrossFit session. DOMS was assessed using a visual analog scale at 24 and 48 hours after the CrossFit session.

Eligibility criteria: Inclusion Criteria:

* Age: 18-35 years.
* Body mass index: 18.5-30 kg/m2.
* Ability to understand the instructions, objectives, and study protocol.
* Minimum of 3 years of experience in crosstraining, with at least 6 hours of weekly training over the past 3 months.
* Resident on the island of Tenerife.

Exclusion Criteria:

* History of a significant adverse cardiovascular event, renal insufficiency, cirrhosis, eating disorder, weight control surgical intervention, or type 2 diabetes mellitus.
* Any chronic pathology in which the intake of nutritional supplements, especially pungent components, is not recommended.
* Any condition that, in the investigator's judgment, would impair the ability to participate in the study or represent a personal risk to the participant.
* Use of medications that may affect the study results.
* Unstable body weight for 3 months prior to the start of the study (\> 4 kg loss or gain in weight).
* Active tobacco abuse or illicit drug use, or history of treatment for alcohol abuse.
* On a special diet or prescribed for other reasons (e.g., celiac disease).

Primary outcomes:
measure: Performance
timeFrame: 60min
measure: Performance
timeFrame: 60min
Secondary outcomes:
measure: Heart rate
timeFrame: 60min
measure: Subjective fatigue throughe the RPE scale
timeFrame: 60min
measure: Recovery
timeFrame: 60min
measure: Delayed-onset muscle soreness (DOMS)
timeFrame: 60min
measure: Capillar lactate levels
timeFrame: 60min
measure: Performance: Weight used in the crosstraining session
timeFrame: 60min
measure: Performance: Time performed in the crosstraining session
timeFrame: 60min
Other outcomes:
Locations:
city: Tenerife
country: Spain
facility: Universidad de la Laguna
Study officials:
References: