Clinical trial NCT06562283: Evaluation of the Reproducibility of a Fatigability Test Fitted to Patients With Spinal Muscular Atrophy
Official title: Evaluation of the Reproducibility of a Fatigability Test Fitted to Patients With Spinal Muscular Atrophy
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Spinal Amyotrophy
Infantile Spinal Muscular Atrophy
Juvenile Spinal Muscular Atrophy
Keywords: Spinal Muscle Atrophy
Neuromuscular performance
Fatigue
Peripheral fatigue
Lead sponsor: Centre Hospitalier Universitaire de Saint Etienne
Sponsor class: OTHER
First posted: 2024-08-20
Enrollment: 80
Sex: ALL
Minimum age (years): 6
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: OTHER

Brief summary: Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease caused by the degeneration of motor neurons in the anterior horn of the spinal cord, due to the absence of the SMN1 gene and the resulting lack of SMN protein. Some patients with particularly severe forms (types 0 or 1) die before the age of 2 in the absence of treatment, while others retain autonomous walking throughout their lives, with no reduction in life expectancy. Three treatments aimed at restoring SMN (TRS) protein expression have recently been approved by the US Food and Drug Administration and the European Medicines Agency (i.e. Nusinersen / Onasemnogene Abeparvovec / Risdiplam). Patients treated with TRS after the onset of symptoms (symptomatic patients) may show significant motor improvement, but retain difficulties such as muscle weakness and fatigue leading to limitations in activities of daily living. The aim of this study is to adapt a fatigability test, widely validated in its original version in different populations (QIF test), but adapted in this protocol to the motor level and low abilities of certain SMA patients. Our objectives are to determine whether these assessments are feasible in SMA patients, reproducible, and relevant for monitoring this population, either routinely or for future clinical trials.


Eligibility criteria: Inclusion Criteria:

* Genetically confirmed spinal muscular atrophy
* Age ≥ 6 years
* No orthopaedic surgery in the 6 months prior to inclusion
* Informed consent signed by the patient(s) or parent(s)/legal guardian(s) and assent of the patient
* Affiliated or beneficiary of a health insurance scheme (for inclusion in France)

Exclusion Criteria:

* Other condition that may significantly interfere with the assessment of the SMA and which is clearly unrelated to the disease
* Other associated neurological disease
* Joint deformities that prevent correct and comfortable positioning with the various different measuring devices (thumb-index clamp, handgrip and QIF-test)
* Contraindication to transcranial magnetic stimulation

Primary outcomes:
measure: Feasibility of a fatigability test adapted to the motor level of the entire population of patients with spinal muscular atrophy.
timeFrame: Day : 1
Secondary outcomes:
measure: Tolerance of fatigability test - Pain
timeFrame: Day : 1
measure: Tolerance of fatigability test - RPE
timeFrame: Day : 1
measure: Tolerance of fatigability test - AEs
timeFrame: Day : 1
measure: Reproducibility of the fatigability test
timeFrame: Day : 1
measure: Reproducibility of the central and peripheral components of fatigue - VA
timeFrame: Day : 1
measure: Reproducibility of the central and peripheral components of fatigue - magnetic jerk
timeFrame: Day : 1
measure: Perceived fatigue - FACIT-F
timeFrame: Day : 1
measure: Perceived fatigue - PedsQL 4.0
timeFrame: Day : 1
Other outcomes:
Locations:
city: Lyon
country: France
facility: HCL - Hôpital Croix Rousse
city: Lyon
country: France
facility: HFME - Hospices Civils de Lyon
city: Paris
country: France
facility: Aphp - Hopital Pitie Salpetriere
city: Saint-Étienne
country: France
facility: Unités de Myologie et de Médecine du Sport
Study officials:
affiliation: CHU SAINT-ETIENNE
name: Leonard FEASSON, MD PhD
role: PRINCIPAL_INVESTIGATOR
References: