louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06351709: Acute Effects of Heat, Cold and Stretching on Knee Proprioception and Vertical Jump
Official title: Acute Effects of Heat, Cold and Stretching on Knee Proprioception and Vertical Jump
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Keywords: proprioception
vertical jump
heat
streching
cold pack
Lead sponsor: Istanbul Bilgi University
Sponsor class: OTHER
First posted: 2024-04-08
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of our study is to investigate the effects of heat, cold and stretching on knee proprioception and vertical jump. 60 healthy individuals were randomized into hot, cold, stretching and control groups of 15 each. Pre-test and post-test measurements were made immediately after the application. Knee proprioception was measured with a digital goniometer using the EPD (joint position sense) test. Vertical jump heights were measured with contact mat by countermovement (CMJ) and squat splash (SQS) tests.


Eligibility criteria: Inclusion Criteria:

* Being between the ages of 18-30
* Agreeing to participate in the study and being informed Approving the Volunteer Consent Form

Exclusion Criteria:

* Having a history of surgery in the knee area
* Movement in lower extremity joints that may affect measurements have limitations.
* Having vision, hearing and balance impairment.
* May cause peripheral neuropathy and deep sensory loss, or loss of proprioception may be caused by other mechanisms having diseases.
* Have a neurological or systemic disease that affects balance and coordination have.
* Describing very severe pain in any part of the lower extremity.
* Being pregnant.
* Having cognitive dysfunction, lack of cooperation
* Having any disease that may cause inability to dry

Primary outcomes:
measure: Vertical Jump Distance Measurement
timeFrame: Before and immediately after application
measure: Joint Position Sense Measurement
timeFrame: Before and immediately after application
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: İstanbul Medipan Tıp Merkezi
Study officials:
References:
Clinical trial NCT01779609: ET-blockade and Exercise-induced Vascular Adaptations in T2DM
Official title: Effect of a Dual ET(Endothelin)-Blocker on Exercise Induced Vascular Adaptations in Type 2 Diabetes Mellitus (T2DM)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Type 2 Diabetes Mellitus
Lead sponsor: Radboud University Medical Center
Sponsor class: OTHER
Collaborators: name: Actelion
First posted: 2013-01-30
Enrollment: 19
Sex: MALE
Minimum age (years): 40
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The purpose of this study is to establish the effect of ET blockade on vascular adaptations during an 8-week exercise program in subjects with T2DM. We hypothesize that combining ET - blockade with exercise training leads to an acute increase of exercise induced blood flow when compared with exercise alone. We expect that this will lead to an optimization of vascular training effect in T2DM.


Eligibility criteria: Inclusion Criteria:

* Type 2 Diabetes Mellitus (\>2 years since diagnosis) OR controls

Exclusion Criteria:

* \<40 years of age
* \>65 years of age
* smoking
* cardiovascular disease
* diabetes related manifest vascular complications
* Type 1 Diabetes Mellitus
* use of Glibenclamide
* use of HIV drugs
* use of calcineurin inhibitors
* use of drugs that interfere with CYP3A4 and CYP2C19

Primary outcomes:
measure: Flow mediated dilation
timeFrame: 8 weeks
Secondary outcomes:
measure: Conduit Artery Dilator Capacity
timeFrame: 8 weeks
measure: Intima-Media Thickness
timeFrame: 8 weeks
measure: Maximal Oxygen Uptake
timeFrame: 8 weeks
Other outcomes:
Locations:
city: Nijmegen
country: Netherlands
facility: Radboud University Nijmegen Medical Centre
state: Gelderland
Study officials:
References:
citation: Schreuder TH, Duncker DJ, Hopman MT, Thijssen DH. Randomized controlled trial using bosentan to enhance the impact of exercise training in subjects with type 2 diabetes mellitus. Exp Physiol. 2014 Nov;99(11):1538-47. doi: 10.1113/expphysiol.2014.081182. Epub 2014 Aug 28.
Clinical trial NCT04647409: Screening for NAFLD in Flanders
Official title: Screening for Non-Alcoholic Fatty Liver Disease (NAFLD) in a General Practitioner Population, in Flanders, Belgium.
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Non-Alcoholic Fatty Liver Disease
Lead sponsor: Hasselt University
Sponsor class: OTHER
First posted: 2020-11-30
Enrollment: 10000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SCREENING

Brief summary: In the Belgian adult population more than half, and numbers are still increasing, of the population is overweight or obese. These people are at risk to develop NAFLD. However, we lack epidemiological data in Belgium. Therefore, it is important to do epidemiological studies to investigate NAFLD prevalence and disease severity based on a non-invasive approach and evaluate how patients are to be referred.


Eligibility criteria: Inclusion Criteria:

* 18 years or older,
* able to understand Dutch,
* able to understand the informed consent

Exclusion Criteria:

* secondary causes of steatosis
* excessive alcohol abuse

Primary outcomes:
measure: CLDQ-NAFLD
timeFrame: baseline
measure: 36-Item Short Form Survey (SF-36)
timeFrame: baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Hasselt
country: Belgium
facility: Hasselt University
Study officials:
affiliation: Hasselt University
name: Geert Robaeys, prof. dr.
role: PRINCIPAL_INVESTIGATOR
affiliation: Hasselt University
name: Leen Heyens, drs.
role: STUDY_CHAIR
References:
Clinical trial NCT02274909: Pilates and PNF Methods Induces Similar Strength Gains
Official title: PILATES AND PNF METHODS INDUCES SIMILAR STRENGTH GAINS, BUT DIFFERENT NEUROMUSCULAR ADAPTATIONS IN ELDERLY WOMEN
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Sarcopenia
Keywords: electromyography
aged
muscle strength
wavelet analysis
pilates
proprioceptive neuromuscular facilitation
Lead sponsor: Universidade Estadual do PiauÍ
Sponsor class: OTHER
First posted: 2014-10-24
Enrollment: 60
Sex: FEMALE
Minimum age (years): 60
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To compare the influence of a training program with Pilates and PNF methods to elderly women on the strength gains and motor control during voluntary contractions

Detailed description: Sixty healthy elderly women were randomly divided into 3 groups: Pilates group (PG), PNF group (PNFG) and Control group (CG). Pilates and PNF groups underwent one-month (three times per week) training program with Pilates and PNF methods, respectively. CG received no intervention along the one month. The maximal isometric force from knee extension and flexion, as well as the EMG signal from quadriceps and biceps femoris were recorded before and after the one-month intervention period. A two-way analysis of variance (3 groups x 2 measures) was used to compare the results from EMG signal, isometric force and force variability and force spectrum. A one-month training program with Pilates and PNF methods induces similar strength gains from knee flexors and extensors, without differences between methods, but PG exhibited greater low gamma drive (i.e., 30-60 Hz band) after the training period. Both Pilates and PNF methods were efficient to improve the muscle strength, but with different neuromuscular adaptations in elderly women. These results give support to the recommendation these methods to older age groups, since the increment of lower limb muscle strength is important for gait, postural stability and performance of daily life activities of this population.

Eligibility criteria: Inclusion Criteria:

* All the subjects were between 60 an 80 years old, sedentary and healthy

Exclusion Criteria:

* Subjects were excluded from the study if they presented any orthopedic, neurological, cardiac, vestibular, visual, or psychiatric impairment which would not allow them to perform all the tasks in the study

Primary outcomes:
measure: EMG measurement
timeFrame: WERE MEASUREMENT BEFORE AND ONE MONTH, IN ALL PARTICPANTS
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT06731309: HS ABSCESSES: I&D VS PUNCH DEBRIDEMENT
Official title: ABSCESS DRAINAGE in HIDRADENITIS SUPPURATIVA: INCISION and DRAINAGE VERSUS PUNCH DEBRIDEMENT
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Hidradenitis Suppurativa (Acne Inversa)
Keywords: punch biopsy tool
drainage
abscess
I&amp;amp;D
Lead sponsor: Erasmus Medical Center
Sponsor class: OTHER
First posted: 2024-12-12
Enrollment: 72
Sex: ALL
Minimum age (years): 16
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: RCT with two intervention groups, one of which is gold standard intervention
Primary purpose: TREATMENT

Brief summary: This randomized-control trial is designed to determine the recurrence rate of HS abscesses following drainage via two methods: I\&D with a linear incision and PD with an 8mm punch biopsy. In this context, recurrence is a newly described HS abscess adjacent to or within the previously operated area, for which a second intervention is deemed necessary. We hypothesize that PD may yield a more favorable recurrence rate. In addition to comparing recurrence rates, this randomized-control trial will also evaluate postprocedural pain, the occurrence and type of complications, and patients' quality of life associated with both procedures. These additional factors are crucial in assessing the overall effectiveness and patient satisfaction associated with each method, further informing the potential establishment of PD as the new gold standard for draining small, painful, acute HS abscesses.


Eligibility criteria: Inclusion Criteria:

* Diagnosed with HS
* Has an abscess requiring drainage with a maximum diameter of 5 centimeters.
* Age 16 years or older
* Willing and able to provide informed consent

Exclusion Criteria:

* Has other conditions that could interfere with the study, as estimated by physician
* Unable to comply with follow-up visits
* Allergic to lidocaine and/or adrenaline.

Primary outcomes:
measure: Recurrence
timeFrame: 1 month
Secondary outcomes:
Other outcomes:
Locations:
city: Rotterdam
country: Netherlands
facility: Erasmus MC
state: Zuid-Holland
Study officials:
References:
Clinical trial NCT00881309: To Compare the Efficacy and Safety of Tripterygium (TW) Versus AZA in the Maintenance Therapy for Lupus Nephritis
Official title: To Compare the Efficacy and Safety of Tripterygium (TW) vs Aza in the Maintenance Therapy for Lupus Nephritis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Lupus Nephritis
Lead sponsor: Nanjing University School of Medicine
Sponsor class: OTHER
First posted: 2009-04-15
Enrollment: 94
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to:

* To access the efficacy of TW compared to Aza in the maintenance therapy for lupus nephritis
* To investigate the safety and tolerability of TW versus Aza in the maintenance therapy for lupus nephritis

Detailed description: Tripterygium (TW) is a Chinese traditional patent drugs in treating chronic glomerulonephritis. It has been used to treat lupus nephritis for many years with less side effects. We compare the efficacy and safety of TW vs Aza in the maintenance therapy of lupus nephritis.

Eligibility criteria: Inclusion Criteria:

1. Patients who signed written informed consent form;
2. SLE patient, aged between 18-60 years, female or male;
3. Patients diagnosed lupus nephritis according to ISN/RPS 2003 classification criteria, class Ⅲ, Ⅳ,Ⅳ+Ⅴ, Ⅲ+Ⅴ or Ⅴ LN by renal biopsy;
4. All patients received induction therapy for 6-12 months, including MMF, CTX, FK506 or multi-target therapy;
5. When recruited in the study, patients received partial remission or complete remission for 3 months;

   * Complete remission: proteinuria \< 0.4 g/24h, negative urine sediment, serum albumin \> 35 g/L, elevated scr \< 0.3 mg/dl, no extra-renal complications;
   * Partial remission: proteinuria \< 1.0 g/24h, urine RBC \< 500000/ml without casts, serum albumin \> 35 g/L, elevated scr \<0.3 mg/dl, no extra-renal complications.

Exclusion Criteria:

1. Patients who didn't sign written informed consent form or could not obey the protocol;
2. Patients who didn't received the CR or PR criterion;
3. Patients who have impaired liver function, with ALT/GPT or AST/GOT twice more than the normal upper limit;
4. WBC \< 3000/mm3 in peripheral blood;
5. Patients with abnormal of central nervous system.

Primary outcomes:
measure: complete remission rate
timeFrame: 2 years
Secondary outcomes:
measure: renal relapse
timeFrame: 2 years
measure: partial remission
timeFrame: 2 years
Other outcomes:
Locations:
city: Nanjing
country: China
facility: Research Institute of Nephrology,Jinling Hospital
state: Jiangsu
Study officials:
affiliation: Nanjing University School of Medicine
name: Weixin Hu, Doctor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05843409: Mindfulness-based Stress Reduction (MBSR) for Reduction of Chronic Pain and Drug Therapie
Official title: Mindfulness-based Stress Reduction or Usual Treatment for Treatment of Chronic Pain in an Italian Hospital
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Chronic Pain
Lead sponsor: Azienda Socio Sanitaria Territoriale di Lecco
Sponsor class: OTHER
First posted: 2023-05-06
Enrollment: 200
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Randomized Controlled Trial (RCT)
Primary purpose: TREATMENT

Brief summary: Mindfulness-Based Cognitive Therapy (MBCT) combines ideas of traditional cognitive therapies with meditative practices aimed at cultivating mindfulness. Mindfulness-based stress reduction (MBSR) is considered one of the original mindfulness-based interventions. It has been modified to be offered virtually,which has been useful throughout the COVID pandemic, and more importantly, has served to inform other mindfulness approaches, such as trauma-focused therapy. The investigators want to assess the efficacy of MBSR in patients with Chronic Pain undergoing drug treatment.

Detailed description: Mindfulness helps develop the ability to observe and detach from our mental, sensory, and emotional states, and thus increases our awareness and ability to manage emotions.

In the experimental arm, some have been foreseen group sessions, in which a maximum of ten people participate on the Mindfulness-based stress reduction (MBSR).

The protocol provides for eight meetings (one and a half or two hours each) on a monthly basis, for a total duration, therefore, of twelve months.

Eligibility criteria: Inclusion Criteria:

* Patients being treated for Chronic Pain
* Patients with Chronic Pain in Pharmacological Therapy

Exclusion Criteria:

* Patients with Chronic Pain not in Pharmacological Therapy
* Patients without Chronic Pain

Primary outcomes:
measure: Chronic pain assessed with the Brief Pain Inventory (BPI)
timeFrame: 1 year
Secondary outcomes:
measure: Quality of life assessore with EQ5D
timeFrame: 1 year
measure: Drug assumption
timeFrame: 1 year
Other outcomes:
Locations:
city: Lecco
country: Italy
facility: ASST Lecco
Study officials:
affiliation: Rn PhD, Department of Anesthesia and Critical Care, Asst Lecco
name: Vincenzo Damico
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01058109: Study of the Effect of a Calcium-rich Diet on Bone Health in Girls
Official title: Effect of Calcium Foods on Bone Quality in Pubertal Females
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Bone Health
Keywords: bone health, bone density, bone mass
Lead sponsor: Creighton University
Sponsor class: OTHER
First posted: 2010-01-28
Enrollment: 65
Sex: FEMALE
Minimum age (years): 9
Maximum age (years): 9
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The aim of this experimental study was to test the effect of increasing dietary calcium intake to 1500 mg/day on increases in bone quality in adolescent females. The hypothesis to be tested is: adolescent females who consume a high calcium diet will have a greater increase in bone quality, as measured by densitometry and ultrasound, than adolescent females who consume their usual dietary calcium intake.


Eligibility criteria: Inclusion Criteria:

- Inclusion criteria were being female and nine years of age with usual dietary calcium intake 1100 mg/day or less.

Exclusion Criteria:

* Exclusion criteria included history of any of the following: lactose intolerance, milk allergy, corticosteroid or anticonvulsant therapy, familial hypercholesterolemia, mental or physical handicaps, cancer, rheumatoid arthritis, asthma, or any significant health problem reported by the parents. We also excluded any child who had a body mass index (BMI)85th percentile for age and gender and children who practiced or played any organized sport (including gymnastics or dance) more than three times per week.

Primary outcomes:
measure: The specific aim of this project was to test the effect of increasing dietary calcium intake to 1500 mg/day on increases in bone quality in pubertal females beginning at age nine.
timeFrame: 9 years
Secondary outcomes:
Other outcomes:
Locations:
city: Omaha
country: United States
facility: Creighton University
state: Nebraska
Study officials:
affiliation: Creighton University
name: Joan M Lappe, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01938209: A Comparison of Seated Thoracic Manipulation and Targeted Supine Thoracic Manipulation on Cervical Flexion Motion and Pain
Official title: A Randomized Control Trial of the Immediate Effects of Seated Thoracic Manipulation and Targeted Supine Thoracic Manipulation on Cervical Spine Flexion Range of Motion and Pain
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Neck Pain
Lead sponsor: Chatham University
Sponsor class: OTHER
Collaborators: name: Megan J. Olson Hunt
First posted: 2013-09-10
Enrollment: 39
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Thirty-nine patients with cervical spine pain were randomly assigned to either a seated thoracic manipulation or targeted supine thoracic manipulation group. Pain and flexion range of motion measures were taken before and after the intervention.

Detailed description: DESIGN: Randomized clinical trial OBJECTIVES: To determine the effectiveness of seated thoracic manipulation versus targeted supine thoracic manipulation on cervical spine pain and flexion range of motion. There is evidence that thoracic spine manipulation is an effective treatment for patients with cervical spine pain. This evidence includes a variety of techniques to manipulate the thoracic spine. While each of them is effective, no research has compared techniques to determine which produces the best outcomes.

METHODS: Thirty-nine patients with cervical spine pain were randomly assigned to either a seated thoracic manipulation or targeted supine thoracic manipulation group. Pain and flexion range of motion measures were taken before and after the intervention.

Eligibility criteria: Inclusion Criteria:

* Inclusion criteria required patients to be between 18-60 years old with a primary complaint of neck pain

Exclusion Criteria:

* identification of red flags suggestive of nonmusculoskeletal etiology, history of whiplash injury within six weeks of the initial visit, diagnosis of cervical spine stenosis, central nervous system involvement, or signs of nerve root compression (two of the following limited at the same level: strength, sensation, reflexes).

Primary outcomes:
measure: neck pain
timeFrame: pain measure taken immediately on first visit
Secondary outcomes:
measure: neck range of motion
timeFrame: range of motion assessed immediately in first visit
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05583409: SBRT Combined With Osimertinib Compared With Osimertinib for Stage IV NSCLC
Official title: Effect of SBRT Combined With Osimertinib Compared With Osimertinib Alone for Stage IV Non-small Cell Lung Cancer
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Stage IV Non-small Cell Lung Cancer
Lead sponsor: Tongji Hospital
Sponsor class: OTHER
Collaborators: name: Hubei Cancer Hospital
First posted: 2022-10-17
Enrollment: 72
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: SBRT plus Osimertinib versus Osimertinib
Primary purpose: TREATMENT

Brief summary: This is a Prospective, Multicenter, Randomized Controlled study to evaluate Stereotactic Body Radiation Therapy (SBRT) as a potential treatment for stage IV non-small cell lung cancer (NSCLC) that has a mutated epidermal growth factor receptor (EGFR) and has been receiving treatment with Osimertinib


Eligibility criteria: Inclusion Criteria:

1. Patients must have biopsy proven metastatic NSCLC (Stage IV).
2. Patients receiving first-line Osimertinib for EGFR mutant-positive for 3 months and achieved stable disease or partial response.
3. Age 18 to 75 years old.
4. Patients must have measurable disease at baseline.
5. The amount of metastatic focus \<5.
6. ECOG score 0-2 7 Adequate normal organ and marrow function for TKI treatment and radiotherapy.

8. Patients must has sensitizing EGFR mutation (e.g. exon 19 deletion or exon 21 L858R) 9. Patients must provide written informed consent to participate in the study.

Exclusion Criteria:

1. Patients who previously received radiotherapy to the primary site.
2. Patient can't tolerate radiotherapy or targeted therapy;
3. Pregnant or nursing women

Primary outcomes:
measure: PFS
timeFrame: 2 years
Secondary outcomes:
measure: OS
timeFrame: 3 years
Other outcomes:
Locations:
city: Wuhan
country: China
facility: Tongji Hospital Affiliated to Tongji Medical College of Huazhong University of Science and Technology, Wuhan, 430030, Hubei, P. R. China
state: Hubei
Study officials:
affiliation: Tongji Hospital, Affiliated to Tongji Medical College of Huazhong University of Science and Technology
name: Li Zhang, MD,PhD
role: PRINCIPAL_INVESTIGATOR
References: