Clinical trial NCT03452956: Cognitive Impairement In Frontotemporal Dementia
Official title: Cognitive Impairement In Frontotemporal Dementia
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Frontotemporal Degeneration
Progressive Supranuclear Palsy
Multiple System Atrophy
Lead sponsor: University of Pennsylvania
Sponsor class: OTHER
First posted: 2018-03-02
Enrollment: 997
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All individuals with a diagnosis of FTD, PSP, or MSA, previously identified by the PI and sub-investigators through other FTD studies (protocol number 702681) and through the PI's extensive FTD clinical practice at the University of Pennsylvania and at Pennsylvania Hospital's Department of Neurology, will be recruited through letters, brochures, and study flyers.

Brief summary: This is an observational study that aims to better understand the genetic causes of frontotemporal degeneration (FTD), Multiple Systems Atrophy (MSA), and Progressive Supranuclear Palsy (PSP). It is hoped the information gathered in this study will help lead to better diagnostics and future treatments.

Detailed description: Comparative and longitudinal studies reveal clinical differences between subgroups of patients with frontotemporal dementia (FTD), including Progressive Non-fluent Aphasia (PNFA), Semantic Dementia (SD), patients with a disorder of social comportment and personality (SOC), and non-aphasic patients with executive dysfunction (EXEC). MRI studies of cortical atrophy and fMRI studies show correlated neural defects in FTD subgroups. The investigators will obtain converging evidence from multiple sources to test hypotheses about the neural basis for cognitive functions such as semantic memory, grammatical processing, and social functioning in these FTD subgroups, while improving clinical care for these patients. Recent studies have linked progressive supra nuclear palsy (PSP) and multiple systems atrophy (MSA) to FTD. The investigators will obtain comparable neuropsychological and biomarker data in order to compare these patient groups.

Eligibility criteria: Inclusion Criteria:

* Individuals who have been diagnosed with FTD, PSP, and MSA

Exclusion Criteria:

* Individuals under 18 years of age
* People with pacemakers or certain metallic implants
* pregnant women

Primary outcomes:
measure: Progression
timeFrame: This is a natural history study - participants are followed from date of enrollment until death, withdrawl, or funding is no longer available, or until 984 months have passed
Secondary outcomes:
measure: Impaired semantic memory in Semantic Dementia (SD).
timeFrame: This is a natural history study - participants are followed from date of enrollment until death, withdrawl, or funding is no longer available, or until 984 months have passed
Other outcomes:
measure: Effortful speech in Progressive Nonfluent Aphasia (PNFA)
timeFrame: This is a natural history study - participants are followed from date of enrollment until death, withdrawl, or funding is no longer available, or until 984 months have passed
measure: Social disinhibition and rule violation in FTD
timeFrame: This is a natural history study - participants are followed from date of enrollment until death, withdrawl, or funding is no longer available, or until 984 months have passed
Locations:
city: Philadelphia
country: United States
facility: University of Pennsylvania
state: Pennsylvania
Study officials:
References: