Clinical trial NCT00158197: Long-term Behavior Change - 1
Official title: Behavior Change: Reinforcement Schedule Effects
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Amphetamine-related Disorders
Keywords: Adherence
Amphetamine-Related Disorders
Behavior Therapy
Contingency management
Drug Counseling
health behaviors
methamphetamine
sexual risk behaviors
substance dependence
Lead sponsor: Friends Research Institute, Inc.
Sponsor class: OTHER
Collaborators: name: National Institute on Drug Abuse (NIDA)
First posted: 2005-09-12
Enrollment: 119
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine if different reinforcement procedures (i.e., schedules) produce different patterns of long-term abstinence from methamphetamine. We anticipate that the three contingency management conditions will promote longer periods of abstinence in the year following treatment relative to the standard control group. Furthermore, we predict that the intermittent reinforcement procedures will produce longer periods of continued abstinence (i.e., long-term behavior change) in the year following treatment than the continuous reinforcement procedure. Finally, we predict that the intermittent unpredictable schedule will produce longer lasting behavior change than the intermittent predictable schedule. Methamphetamine use will be measured using urine toxicology and self-report of methamphetamine use.

Detailed description: Briefly the four study conditions are: (1) standard treatment which consists of 16 weeks of psychosocial treatment, (2) continuous contingency management which consists of 16 weeks of psychosocial treatment with a contingency management procedure in effect during the first twelve weeks in which vouchers are made available after each provision of a methamphetamine-negative urine test, (3) intermittent predictable contingency management which consists of 16 weeks of psychosocial treatment with a contingency management procedure in effect during the first twelve weeks in which vouchers are available after the provision of every three consecutive methamphetamine-negative urine samples, and (4) intermittent unpredictable contingency management which consists of 16 weeks of psychosocial treatment with a contingency management procedure in effect during the first twelve weeks in which vouchers are available on one day each week (randomly selected after the first week) for the provision of methamphetamine-negative urine samples provided all urine samples since delivery of the last reinforcer were also methamphetamine negative.

Eligibility criteria: Inclusion Criteria:

* Meet Diagnostic and Statistical Manual of Mental Disorders (DSM-IV) criteria for methamphetamine dependence
* Willing and able to comply with study procedures
* Willing and able to provide written informed consent

Exclusion Criteria:

* Have a medical condition that, in the study Principal Investigator (PI's) judgment, might interfere with safe study participation
* Have a recent (past 30 days) history of suicide attempts and/or current serious suicidal intention or plan as assessed by the Beck Depression Inventory (BDI)
* Have a history of violent criminal behavior or be on parole
* Any other circumstances that, in the opinion of the PI, would interfere with safe study participation

Primary outcomes:
measure: Methamphetamine Use During Intervention
timeFrame: 3x/week for 16 weeks
measure: Methamphetamine Use, Measured by Number of Consecutive Days of Abstinence
timeFrame: 16 Weeks
measure: Methamphetamine Use, Follow-Up
timeFrame: 1x/month for 4 months
Secondary outcomes:
Other outcomes:
Locations:
city: Los Angeles
country: United States
facility: Friends Research Institute
state: California
city: Rancho Cucamonga
country: United States
facility: Friends Research Institute
state: California
Study officials:
affiliation: University of California, Los Angeles
name: John Roll, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Roll JM, Chudzynski J, Cameron JM, Howell DN, McPherson S. Duration effects in contingency management treatment of methamphetamine disorders. Addict Behav. 2013 Sep;38(9):2455-62. doi: 10.1016/j.addbeh.2013.03.018. Epub 2013 Apr 3.