louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01213953: Isolation and Authentication of Mesenchymal Stem Cell-like Progenitor Cells From the Degenerated Intervertebral Disc of Lumbar Spine
Official title: Isolation and Authentication of Mesenchymal Stem Cell-like Progenitor Cells From the Degenerated Intervertebral Disc of Lumbar Spine
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Lower Back Pain
Disc Degeneration
Keywords: Vertebral disc, mesenchymal stem cell.
Lead sponsor: Taipei Medical University WanFang Hospital
Sponsor class: OTHER
First posted: 2010-10-04
Enrollment: 20
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The patients received the surgery of discectomy for the degenerative disc.

Brief summary: The study is designed for evaluating the presence of mesenchymal stem cells of vertebral disc. Isolation and authentication of these cells may be applied for the vertebral disc regeneration and the research tissue engineering.

Detailed description: We will collect the degenerative disc from adults and isolate the mesenchymal stem cell-like precursors cells. The function of osteogenic, chondrogenic, and lipogenic differentiation will be authenticated. The results will offer the information for cell source of tissue engineering in the future.

Eligibility criteria: Inclusion Criteria:

* The adults with disc degeneration（age \>= 20 years old） A. Herniated intervertebral disc. B. Spondylolisthesis. C. Spondylolysis. D. Other causes of disc degeneration.

Exclusion Criteria:

* Age \< 20 years old.
* Pregnancy.
* Spinal tumors.
* Spinal infections.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Taipei Medical University - WanFang Hospital
Study officials:
affiliation: Taipei Medical University Shuang Ho Hospital
name: Hsieh-Hsing Lee
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02062853: Continuous Quality Improvement (CQI) Pilot Study Evaluating the Utility of an Educational Video
Official title: CQI Pilot Study Evaluating the Utility of an Educational Video in the Setting of Topical 5-fluorouracil Therapy to Treat Actinic Keratoses and Its Influence on Patient Satisfaction
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Actinic Keratoses
Lead sponsor: University of California, Davis
Sponsor class: OTHER
First posted: 2014-02-14
Enrollment: 44
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The primary aim of this study is to evaluate the effects of prospective patient education on patient satisfaction with administration of topical 5% 5-fluorouracil cream for the treatment of actinic keratosis involving the face, scalp, upper chest, dorsal hands and forearms. Specifically, this study aims to determine if prospective patient viewing of an educational video delineating treatment effects and expectations improves patient satisfaction and treatment completion rates.


Eligibility criteria: Inclusion Criteria:

* Subjects with a clinical diagnosis of actinic keratoses with at least 6 clinically-diagnosed actinic keratoses on the face, bald scalp, arms, upper chest, OR dorsal hands classified as grade I, mild (slightly palpable actinic keratoses, more easily felt than seen), and II, moderate (moderately thick hyperkeratotic actinic keratoses, easily felt).

Exclusion Criteria:

* Patients using interferon or interferon inducers, immunomodulators, cytotoxic or immunosuppressor drugs, corticosteroids, retinoids, or investigational drugs within 4 weeks prior to enrollment.
* Patients who have been treated with any topical drug for actinic keratoses lesions less than 8 weeks prior to enrollment.
* Patients with invasive tumors within the treated area (e.g. invasive squamous cell carcinoma)
* Patients who have exhibited any dermatological disease within the treated or adjacent (3 cm distance) area at the time of screening.
* Patients who have known allergies to fluorouracil (5-FU).

Primary outcomes:
measure: Level of Patient Satisfaction in Relation to Treatment Effects and Expectations of 5-fluorouracil Cream
timeFrame: 4 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Sacramento
country: United States
facility: University of California-Davis, Department of Dermatology
state: California
Study officials:
affiliation: University of California, Davis
name: Nasim Fazel, M.D., D.D.S.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06679153: A Phase 2 Study of VVN461 Ophthalmic Solution for Noninfectious Anterior Uveitis
Official title: A Randomized, Double-masked, Active-controlled, Multi-center Phase 2 Clinical Study Evaluating the Efficacy and Safety of 0.5% and 1.0% VVN461 Ophthalmic Solution in Patients With Noninfectious Anterior Uveitis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Anterior Uveitis
Lead sponsor: VivaVision Biotech, Inc
Sponsor class: INDUSTRY
First posted: 2024-11-07
Enrollment: 89
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This is a multicenter, double-masked, randomized, active-controlled, parallel-comparison study conducted at sites in the China in subjects with Noninfectious Anterior Uveitis

Detailed description: In this study, subjects who meet the inclusion/exclusion criteria will be randomized to receive one of the three treatments prednisolone acetate during the Screening/Baseline Visit (Day-2 to Day 1). Starting from Visit 1 (Day 1), subjects will be administered one drop of the investigational product in the study eye in following dose regimens: 6 times per day (Q2h, 2 hours apart) for 7 days; 4 times per day (QID) for 7 days；2 times per day (BID) for 7 days；once a day (QD) for 7 days. Subjects will return to clinic for study assessments on Day 3 (Visit 2), Day 7 (Visit 3), Day 14 (Visit 4), Day 21 (Visit 5) and Day 28 (Visit 6, end of study) or early withdrawal/termination visit.

Eligibility criteria: Inclusion Criteria:

* Age 18-70 years at the time providing signed informed consent
* At least 1 eye diagnosed with noninfectious anterior uveitis at the time of screening
* Willing and able to comply with study requirements and visit schedule

Exclusion Criteria:

* Diagnosis of intermediate uveitis, posterior uveitis or panuveitis in either eye at the time of screening

Primary outcomes:
measure: ACC score of ≥2 grade from baseline at Day 14
timeFrame: Day 14
Secondary outcomes:
measure: ACC score of 0
timeFrame: Baseline to Day 28
Other outcomes:
Locations:
city: Beijing
country: China
facility: Peking University First Hospital
Study officials:
References:
Clinical trial NCT06218953: The Impact of Preoperative Anemia on Postoperative Anemia and Related Nutrient Abnormalities After Bariatric Surgery
Official title: The Impact of Preoperative Anemia on Postoperative Anemia and Related Nutrient Abnormalities After Bariatric Surgery
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Anemia
Bariatric Surgery
Lead sponsor: China-Japan Friendship Hospital
Sponsor class: OTHER
First posted: 2024-01-23
Enrollment: 400
Sex: ALL
Minimum age (years): 16
Maximum age (years): 70
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: OTHER
Sampling method: PROBABILITY_SAMPLE
Study population: Patients who underwent bariatric surgery aged between 16 and 70 years will receive follow-up for at least 1 year.

Brief summary: This study aims to assess the impact of preoperative anemia status on anemia and related nutrient abnormalities 1 year after bariatric surgery.

Detailed description: This study aims to assess the impact of preoperative anemia status on anemia and related nutrient abnormalities (ferritin deficiency, vitamin B12 deficiency, folate deficiency, and low transferrin saturation level) at 1 year after bariatric surgery.

Eligibility criteria: Inclusion Criteria:

* Patients who underwent bariatric surgery (sleeve gastrectomy and Roux-en-Y gastric bypass)
* Age between 16 and 70 years
* Patients who have complete 1-year follow-up data

Exclusion Criteria:

* Baseline renal failure
* Vegetarian
* Postoperative bleeding (it was defined as a drop in hemoglobin levels \> 3 g/dL or a confirmed blood loss requiring treatment after surgery)

Primary outcomes:
measure: Odds ratio (OR) for anemia by preoperative anemia status
timeFrame: 1 year
Secondary outcomes:
measure: Percentage of postoperative anemia
timeFrame: 1 year
measure: Percentage of anemia severity
timeFrame: 1 year
measure: Percentage of ferritin deficiency
timeFrame: 1 year
measure: Percentage of vitamin B12 deficiency
timeFrame: 1 year
measure: Percentage of folate deficiency
timeFrame: 1 year
measure: Percentage of low transferrin saturation level
timeFrame: 1 year
Other outcomes:
Locations:
city: Beijing
country: China
facility: Yuntao Nie
Study officials:
affiliation: China-Japan Friendship Hospital
name: Yuntao Nie, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05635253: Influence of Polishing After Bleaching on Color Change and Enamel Morphology
Official title: Influence of Polishing After Bleaching on Color Change and Enamel Morphology: Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Tooth Discoloration
Morphologic Change
Tooth Sensitivity
Lead sponsor: Universidade Federal do Para
Sponsor class: OTHER
First posted: 2022-12-02
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: PREVENTION

Brief summary: This trial evaluated the influence of polishing on enamel color change after in-office bleaching treatment. It also evaluated the influence of polishing on tooth morphology and sensitivity.


Eligibility criteria: Inclusion Criteria:

* Individuals aged 18 to 30 years old of both sexes;
* With good oral hygiene;
* With no sensitivity to tactile and evaporative stimuli;
* Who have not undergone previous bleaching treatment, and with no caries lesions.

Exclusion Criteria:

* patients undergoing fixed orthodontic treatment;
* patients allergic to the bleaching product;
* drug users or pregnant women;
* patients with carious lesions, defective restorations and/or periodontal disease, patients with systemic diseases, pulpitis or patients using analgesics.

Primary outcomes:
measure: Influence of polishing on color after tooth whitening
timeFrame: 14 days
Secondary outcomes:
measure: Surface morphology of whitening enamel with and without polishing
timeFrame: 14 days
measure: Influence of polishing on sensitivity after tooth whitening
timeFrame: 14 days
Other outcomes:
Locations:
city: Belém
country: Brazil
facility: Cecy Martins Silva
state: PA
Study officials:
References:
Clinical trial NCT05527353: AMH for the Identification of PCOM in PCOS Diagnosis
Official title: Human Anti-MülleRian Hormone for Diagnosis of PCOS Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Polycystic Ovary Syndrome
Keywords: polycystic ovary syndrome
PCOS
anti-müllerian hormone
AMH
antral follicle count
polycystic ovarian morphology
Lead sponsor: Oulu University Hospital
Sponsor class: OTHER
Collaborators: name: Roche Diagnostics GmbH
First posted: 2022-09-02
Enrollment: 1800
Sex: FEMALE
Minimum age (years): 32
Maximum age (years): 37
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: As the study is population-based, all non-pregnant women born in Northern Finland between July 1985-December 1987 will be invited to participate in the study. Most women will be white with a small minority (estimated below 3%) of indigenous Sámi people.

Brief summary: The purpose of this study is to validate the anti-müllerian hormone (AMH) cut-off established and validated in the APHRODITE study, for the determination of PCOM as part of the diagnosis of PCOS, using the Elecsys AMH Plus immunoassay.

Detailed description: The study participants will be women born July 1985-Dec 1987 in Northern Finland; the study partially links to the Northern Finland Birth Cohort 1986. Female subjects included in this cohort will be invited to participate in the study with the aim to enroll up to 1800 subjects. Each enrolled subject will have one study visit, where the clinical data required for assessing their PCOS status will be recorded, including a gynecological examination by transvaginal ultrasound to determine polycystic ovarian morphology (PCOM) status (antral follicle count and ovarian volume). Study subjects will also have blood drawn for serum collection, where hormonal parameters relevant for PCOS will be measured. The collected serum will also be used to measure the AMH levels using the Roche Elecsys AMH test.

Eligibility criteria: Inclusion Criteria:

* Female
* Born July 1985-Dec 1987 in Northern Finland
* Signed informed consent regarding ROCHE collaboration

Exclusion Criteria:

* Unwilling to undergo gynecological examination including transvaginal ultrasound (TVUS)
* Unwilling to have blood drawn
* Pregnancy

Primary outcomes:
measure: The validation of the performance of the AMH cut-off, established in the APHRODITE study, to diagnose PCOM in the context of PCOS diagnosis.
timeFrame: Baseline
Secondary outcomes:
measure: Prevalence of PCOS in general population
timeFrame: Baseline
Other outcomes:
Locations:
city: Oulu
country: Finland
facility: Oulu University Hospital
Study officials:
affiliation: Oulu University Hospital, University of Oulu
name: Terhi T Piltonen, Professor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04432753: Effect of Incidental Findings Information on Lung Cancer Screening Intent
Official title: Effect of Incidental Findings Information on Lung Cancer Screening Intent: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Neoplasm of Lung
Decision Support Techniques
Mass Screening
Keywords: Incidental Findings
Lead sponsor: UNC Lineberger Comprehensive Cancer Center
Sponsor class: OTHER
Collaborators: name: UNC Cecil G. Sheps Center for Health Services Research
First posted: 2020-06-16
Enrollment: 419
Sex: ALL
Minimum age (years): 55
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SCREENING

Brief summary: This online randomized controlled trial seeks to determine if inclusion of incidental findings information in a lung cancer screening decision aid affects screening intent among screening-eligible individuals. Participants will view either a decision aid with incidental findings information or without and indicate their intent to pursue lung cancer screening.

Hypothesis: Inclusion of incidental findings in a decision aid will decrease intent to screen among participants.


Eligibility criteria: Inclusion Criteria:

* 55-80 year old male or female
* Current or former smoker who quit within the last 15 years
* At least 30 pack years of smoking

Exclusion Criteria:

* N/A

Primary outcomes:
measure: Percentage of individuals who plan to pursue lung cancer screening
timeFrame: Day 1
Secondary outcomes:
measure: Mean score on scale of lung cancer screening knowledge
timeFrame: Day 1
measure: Mean rating of benefit and harms of screening
timeFrame: Day 1
measure: Percentage of Time Lung Cancer Screening Benefit and Harms are ranked first and last
timeFrame: Day 1
measure: Mean ranking of benefit and harms of screening
timeFrame: Day 1
measure: Percentage of time each lung cancer screening harm is ranked highest of the five potential harms
timeFrame: Day 1
measure: Mean ranking of incidental findings attribute
timeFrame: Day 1
Other outcomes:
Locations:
city: Chapel Hill
country: United States
facility: University of North Carolina at Chapel Hill
state: North Carolina
Study officials:
affiliation: University of North Carolina, Chapel Hill
name: Stephen Clark, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: University of North Carolina, Chapel Hill
name: Daniel Jonas, MD, MPH
role: STUDY_DIRECTOR
References:
citation: Clark SD, Reuland DS, Brenner AT, Jonas DE. Effect of Incidental Findings Information on Lung Cancer Screening Intent: a Randomized Controlled Trial. J Gen Intern Med. 2022 Nov;37(14):3676-3683. doi: 10.1007/s11606-022-07409-4. Epub 2022 Feb 2.
Clinical trial NCT04523753: Endoscopy for Bleeding Situations in Surgical Patients
Official title: Emergency Endoscopy for Gastrointestinal Bleeding Situations in Surgical Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hemorrhage
Keywords: surgical patients, gastrointestinal bleeding
Lead sponsor: University Hospital Tuebingen
Sponsor class: OTHER
First posted: 2020-08-24
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients of the University Hospital of Tübingen Department of General, Visceral and Transplantation Surgery with gastrointestinal bleeding situations were enrolled for this retrospective analysis

Brief summary: Retrospective analysis of surgical patients with relevant gastrointestinal bleeding situations and indication for endoscopy for bleeding

Detailed description: We performed an analysis of all adult, surgial patients with indication for emergency endoscopy because of relevant gastrointestinal bleeding situations. A retrospective analysisof the incidence, causes, endoscopic findings and therapy and the outcome of bleeding situations during a 24-mounths interval in the years 2017, 2018 and 2019 was performed at our tertiary centre. Informed consent was obtained from all participants. Patient records as well as database were analyzed for therapy-specific items.

Eligibility criteria: Inclusion Criteria:

* Patients of the University Hospital of Tübingen Department of General, Visceral and Transplantation Surgery with gastrointestinal bleeding situations

Exclusion Criteria:

* younger patients
* patients without indication for emergency endoscopy for bleeding situations

Primary outcomes:
measure: rate identification of bleeding sources
timeFrame: 24 months
Secondary outcomes:
Other outcomes:
Locations:
city: Tuebingen
country: Germany
facility: University Hospital of Tuebingen
Study officials:
References:
Clinical trial NCT01441453: Transient Elastography in Hepatectomy for Hepatocellular Carcinoma
Official title: Value of Transient Elastography in Predicting Postoperative Liver Failure in Patients Undergoing Liver Resection for Hepatocellular Carcinoma.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Surgery
Hepatocellular Carcinoma
Keywords: Hepatocellular carcinoma
Cirrhosis
Liver resection
FibroScan
Lead sponsor: IRCCS Azienda Ospedaliero-Universitaria di Bologna
Sponsor class: OTHER
First posted: 2011-09-27
Enrollment: 120
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The purpose of this study is to determine whether liver transient elastography performed before the surgical procedure is able to predict liver failure in patients undergoing hepatectomy for hepatocellular carcinoma.


Eligibility criteria: Inclusion Criteria:

* Patients already scheduled to undergo liver resection fo hepatocellular carcinoma

Primary outcomes:
measure: Cut-off value of liver stiffness measured in kilopascal (kPa) able to predict the occurrence of postoperative liver failure.
timeFrame: Participants will be followed for the duration of postoperative hospital stay, an expected average of 4 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Bologna
country: Italy
facility: General Surgery and Organ Transplantation Unit, Policlinico Sant'Orsola-Malpighi
Study officials:
affiliation: Policlinico Sant'Orsola-Malpighi, University of Bologna, Italy
name: Matteo Cescon, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04759053: Effectiveness of Core-Needle US Guided Biopsy as Primary Tool For Diagnosis of Thyroid Nodules
Official title: Effectiveness of Core-Needle US Guided Biopsy as Primary Tool For Diagnosis of Thyroid Nodules, A Prospective Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Thyroid Nodule
Thyroid Diseases
Thyroid Gland; Node
Keywords: Thyroid nodule
Core needle biopsy
FNB
Lead sponsor: Kafrelsheikh University
Sponsor class: OTHER
Collaborators: name: Alexandria University
First posted: 2021-02-17
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: The study aimed to determine the best intervention between Core biopsy and Fine needle aspiration in diagnosis of thyroid malignancy.


Eligibility criteria: Inclusion Criteria:

* patients with nodules larger than 1 cm in diameter and suspicious ultrasound criteria with TIRADS category III or higher.

Exclusion Criteria:

* Patients with a history of hemodynamic instability or inadequate coagulation profile were excluded

Primary outcomes:
measure: Number of samples in FNB and CNB matching the final pathology
timeFrame: 7 days
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT00658853: Effective High Aerobic Intensity Endurance Training Regimes in Chronic Obstructive Pulmonary Disease (COPD) Patients
Official title: Effective High Aerobic Intensity Interval Training to Improve Maximal Oxygen Uptake in COPD Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pulmonary Disease, Chronic Obstructive
Hyperoxia
Keywords: COPD
training
VO2peak
performance
ventilation
high aerobic intensity treadmill walking
one leg training by cycling
Lead sponsor: Norwegian University of Science and Technology
Sponsor class: OTHER
First posted: 2008-04-15
Enrollment: 26
Sex: ALL
Minimum age (years): 20
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: 4 times 4 minutes interval training with and without hyperoxia is more effective than low intensity endurance training.


Eligibility criteria: Inclusion Criteria:

* COPD

Exclusion Criteria:

* Heart disease
* Walking or cycling inabilities
* Other diseases

Primary outcomes:
measure: VO2peak
timeFrame: 10 weeks
measure: Ventilation
timeFrame: 10 weeks
measure: FEV1
timeFrame: 10 weeks
measure: Walking performance
timeFrame: 10 weeks
Secondary outcomes:
measure: Quality of life
timeFrame: 3 months
measure: SPSS
timeFrame: 3 months
Other outcomes:
Locations:
city: Trondheim
country: Norway
facility: Norwegian University of Science and Technology
Study officials:
affiliation: Norwegian University of Science and Technology
name: Jan Helgerud, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Bjorgen S, Helgerud J, Husby V, Steinshamn S, Richadson RR, Hoff J. Aerobic high intensity one-legged interval cycling improves peak oxygen uptake in chronic obstructive pulmonary disease patients; no additional effect from hyperoxia. Int J Sports Med. 2009 Dec;30(12):872-8. doi: 10.1055/s-0029-1238292.