Clinical trial NCT04364061: Post Exercise Substrate Oxidation, Appetite and Energy Intakes in Overweight/Obese Postmenopausal Women (EScAPE)
Official title: Comparison of Acute Cycling Modalities on Enjoyment, Post Exercise Substrate Oxidation, Appetite and Energy Intakes Over 24h in Postmenopausal Women With Overweight or Obesity
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Overweight
Postmenopausal
Keywords: Exercise Modalities
Postmenopausal women
High-intensity interval exercise
CHO and FAT oxidation
Appetite
Energy intakes
Enjoyment
Lead sponsor: Laboratoire des Adaptations Métaboliques à l'Exercice en conditions Physiologiques et Pathologiques
Sponsor class: OTHER
Collaborators: name: CREPS Auvergne Rhône-Alpes / Vichy
First posted: 2020-04-27
Enrollment: 12
Sex: FEMALE
Minimum age (years): 50
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: PREVENTION

Brief summary: High-intensity interval exercise (HIIT), as compared to moderate intensity continuous training (MICT), is a time-efficient strategy to decrease total and abdominal fat mass (FM). However, the mechanisms underlying such adaptations are not yet elucidated and research are still needed to establish the optimal HIIT according to subject characteristics. The aim of this study was to compare acute HIIE and MICE cycling exercises on enjoyment, post-exercise substrate oxidation, appetite and energy intakes over 24h in postmenopausal women with overweight or obesity. It is hypothesized that compared with the traditional MICE, HIIE could favor greater enjoyment, higher 2h-post-exercise fat oxidation and a similar energy intakes over 24h despite different post-exercise appetite perceptions.

Detailed description: The aim of this study was to compare acute HIIE and MICE cycling exercises on enjoyment, post-exercise substrate oxidation, and appetite and energy intakes over 24h in postmenopausal women with overweight or obesity.

Using a randomized crossover design, 12 postmenopausal women completed 3 cycling exercises at 6-days intervals:

i) Moderate Intensity Continuous Exercise (MICE) which consisted of 35 min cycling at 60-65% theorical Peak Heart Rate (thPHR) ii) High Intensity Interval Exercise 1 (HIIE 1) 60 cycles of speeding up for 8 s at 80-90%thPHR followed by pedaling slowly for 12 s (20min) iii) High Intensity Interval Exercise 2 (HIIE 2) which consisted of repeated 10 x 1min at 80-90% thPHR followed by pedaling slowly for 1min.

Substrate oxidation (CHO and FAT) were measured at rest and 2h- post exercise. Enjoyment, perceived exertion and appetite were recorded and post-exercise energy intakes were assessed over 24h.

Eligibility criteria: Inclusion Criteria:

* postmenopausal women (spontaneous amenorrhea for at least 12 months)
* with overweight or obesity (BMI \> 25 kg/m2 and ≤ 40 kg/m2)

Exclusion Criteria:

* medical contraindications to intense physical activity,
* painful joints,
* taking hormone replacement therapy,
* taking B-blockers.

Primary outcomes:
measure: Post-exercise (2 hours) CHO and FAT oxidation
timeFrame: 2 hours post-exercise
Secondary outcomes:
measure: Enjoyment
timeFrame: Immediately post-exercise
measure: Rate Perceive Exertion (RPE)
timeFrame: During exercise (5-10-15 and 20 minutes for HIIE1 and 2 ; 9-18-27 and 35 minutes for MICE) which corresponds at 25-50-75 and 100% of bout completion.
measure: Appetite
timeFrame: Before, immediately post-exercise, 60 minutes and 120 minutes post-exercise
measure: Energy intakes
timeFrame: 24 hours post-exercise
Other outcomes:
Locations:
city: Bellerive-sur-Allier
country: France
facility: CREPS Auvergne Rhône-Alpes / Vichy
state: Allier
Study officials:
affiliation: CREPS Auvergne Rhône-Alpes / Vichy
name: Claire MOREL, Dr
role: PRINCIPAL_INVESTIGATOR
References: