Clinical trial NCT02568371: Biobank Based on the i-Share Student Cohort
Official title: Biobank Based on the i-Share Student Cohort
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Healthy
Keywords: biobank
DNA
genetic
young adults
cohort study
Lead sponsor: University Hospital, Bordeaux
Sponsor class: OTHER
Collaborators: name: National Research Agency, France
First posted: 2015-10-05
Enrollment: 1997
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The bio-Share study is a biological repository embedded within the i-Share study, aiming at collecting blood samples from a subset of 2000 i-Share participants volunteering for this ancillary project.

Brief summary: The bio-Share project aims at collecting blood samples in students participating in the i-Share cohort (www.i-share.fr). Investigators aim at setting up a platform that will enable investigators in the future to study biological determinants of conditions that affect young adults and to test certain hypotheses on the pathophysiology and mechanisms underlying diseases occurring both at a young age and later in life (as early exposures may also impact late onset diseases)

Detailed description: The i-Share cohort was set up to study various important aspects of students' health and to better understand early mechanisms contributing to the occurrence of common diseases representing an important public health burden. The i-Share cohort is funded by an "investment for the future grant" from the French National Research Agency (ANR-10-COHO-05-01) with the aim to recruit 30000 students at the University of Bordeaux, and a few additional partner universities in France and abroad (www.i-share.fr).

The bio-Share study is a biological repository embedded within the i-Share study, aiming at collecting blood samples (for genetic analyses as well as measurement of other biomarkers) from a subset of 2000 i-Share participants volunteering for this ancillary project.

The goal is to set up a platform that will enable investigators in the future to study biological determinants of conditions that affect young adults and to test certain hypotheses on the pathophysiology and mechanisms underlying diseases occurring both at a young age and later in life (as early exposures may also impact late onset diseases).

The biobank will comprise the following biological materials: plasma, serum, whole blood, red blood cells, DNA, RNA. Levels of fasting glucose and lipid levels (total cholesterol, HDL-cholesterol, LDL-cholesterol, triglycerides) will be returned to participants.

Eligibility criteria: Inclusion Criteria:

* Be an i-Share participant in Bordeaux
* Being aged 18 years or more
* Being affiliated or beneficiary of a social security
* Having filled out the first online i-Share questionnaire
* Having signed a written informed consent

Exclusion Criteria:

* Pregnant or breastfeeding women,
* Persons who cannot personally give their consent and adults under guardianship.

Primary outcomes:
measure: The acquisition date of blood samples
timeFrame: Day 1
measure: The number of the aliquots for each of the stored biological samples
timeFrame: Day 1
measure: The total volume of the aliquots for each of the stored biological samples
timeFrame: Day 1
Secondary outcomes:
measure: Glucose (fasting)
timeFrame: Day 1
measure: Total cholesterol (fasting)
timeFrame: Day 1
measure: High-density lipoprotein cholesterol (fasting)
timeFrame: Day 1
measure: Low-density lipoprotein-cholesterol (fasting)
timeFrame: Day 1
measure: Triglycerides (fasting)
timeFrame: Day 1
Other outcomes:
Locations:
city: Bordeaux
country: France
facility: Centre Hospitalier Universitaire de Bordeaux - PELLEGRIN
state: Aquitaine
Study officials:
affiliation: University of Bordeaux, Inserm U897, Bordeaux University Hospital
name: Stephanie DEBETTE, MD, PhD
role: STUDY_DIRECTOR
affiliation: University of Bordeaux, Inserm U897, Bordeaux University Hospital
name: Christophe TZOURIO, MD, PhD
role: STUDY_DIRECTOR
References: