louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05692583: Correlation Between EPB Entrapment Test and Ultrasound Wrist Findings in Patients With deQuervain's Disease
Official title: Correlation Between EPB Entrapment Test and Ultrasound Wrist Findings in Patients With deQuervain's Disease
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: De Quervain Disease
Keywords: de quervain's disease
anatomical variations
EPB entrapment test
Lead sponsor: Velammal Medical College Hospital and Research Institute
Sponsor class: OTHER
First posted: 2023-01-20
Enrollment: 39
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: all adults \>18 years of age with positive Finkelsteins test are included

Brief summary: The goal of this observational study is to learn about the correlation between EPB entrapment test and ultrasound wrist findings in patients with deQuervain's disease The main questions it aims to answer are:

* if correlation exist between EPB entrapment test and ultrasound wrist findings in patients with deQuervain's disease ?
* if the the correlation aid in deciding management of patients with deQuervain's disease Participants will be subjected to
* EPB entrapment test
* ultrasound examination of wrist


Eligibility criteria: Inclusion Criteria:

* Age \>18
* Radial side wrist pain
* Finkelstein test positive
* Failure of non surgical treatment

Exclusion Criteria:

• Patients who underwent Previous surgical release

Primary outcomes:
measure: EPB entrapment test
timeFrame: 1 day
measure: Ultrasound examination of wrist
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
city: Madurai
country: India
facility: Velammal medical college hospital and research institute
state: Tamil Nadu
Study officials:
affiliation: Sri Ramachandra Institute of Higher Education and Research
name: Srinivasan Rajappa, MS, DNB
role: STUDY_DIRECTOR
affiliation: Velammal Medical College Hospital and Research Institute
name: Vijayaraja Elangovan, MS
role: STUDY_CHAIR
affiliation: Velammal medical college hospital and research
name: Gokul Kumar Jeganathan, MBBS
role: PRINCIPAL_INVESTIGATOR
References:
citation: Finkelstein H. STENOSING TENDOVAGINITIS AT THE RADIAL STYLOID PROCESS. JBJS. 1930 Jul;12(3):509-40.
citation: E E. Zur Pathogenese der Tendovaginitis stenosans. Bruns Beitrage Z Klin Chir. 1927;0:746-55.
citation: GILES KW. Anatomical variations affecting the surgery of de Quervain's disease. J Bone Joint Surg Br. 1960 May;42-B:352-5. doi: 10.1302/0301-620X.42B2.352. No abstract available.
citation: Alexander RD, Catalano LW, Barron OA, Glickel SZ. The extensor pollicis brevis entrapment test in the treatment of de Quervain's disease. J Hand Surg Am. 2002 Sep;27(5):813-6. doi: 10.1053/jhsu.2002.35309.
citation: Lee KH, Kang CN, Lee BG, Jung WS, Kim DY, Lee CH. Ultrasonographic evaluation of the first extensor compartment of the wrist in de Quervain's disease. J Orthop Sci. 2014 Jan;19(1):49-54. doi: 10.1007/s00776-013-0481-3. Epub 2013 Oct 17.
Clinical trial NCT01593683: Waitlist-controlled Trial of a Psychological Education Program for Nurses
Official title: Waitlist-controlled Trial of a Psychological Education Program for Nurses
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Psychological Stress
Keywords: Oncology service
Nursing staff
Psychosocial intervention
Coping skills
Lead sponsor: Massachusetts General Hospital
Sponsor class: OTHER
First posted: 2012-05-08
Enrollment: 42
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The purpose of this study is to test a brief education program for oncology nurses, to enhance their skills for managing psychosocial stressors associated with providing direct patient care. The investigators will explore efficacy of the intervention for reducing psychological stress and medical errors.


Eligibility criteria: Inclusion Criteria:

* Must have RN degree
* Must be employed as an oncology nurse in an inpatient, infusion, or ambulatory care unit

Exclusion Criteria:

* Participation in earlier pilot trial of the intervention

Primary outcomes:
measure: Change from baseline in psychological stress as measured by the Perceived Stress Scale and the Maslach Burnout Inventory
timeFrame: At approximately 16 and 32 weeks post-baseline
Secondary outcomes:
measure: Change in from baseline in medical errors as measured by the Medical Errors Questionnaire
timeFrame: At approximately 16 and 32 weeks post-baseline
Other outcomes:
Locations:
city: Boston
country: United States
facility: Massachusetts General Hospital
state: Massachusetts
Study officials:
affiliation: Massachusetts General Hospital
name: William F Pirl, MD, MPH
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01663883: Optic Nerve Head Autoregulation During Changes in Arterial Blood Pressure
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Decreased Vascular Flow
Keywords: Blood flow autoregulation
optic nerve head blood flow
isometric exercise
Autoregulation
ocular physiology
Lead sponsor: Medical University of Vienna
Sponsor class: OTHER
First posted: 2012-08-13
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: Constant despite changes in perfusion pressure. It is observed in many vascular beds of the human body to prevent that variations in perfusion pressure are directly transmitted into changes in blood flow. This is necessary to prevent ischemia and/or hypoxia during decreased blood flow and bleeding or increased capillary pressure during increased blood flow.

In the eye, several studies have reported that retinal blood flow is autoregulated over a wide range of ocular perfusion pressures. Unfortunately only few data are available for the optic nerve head. To gain data about autoregulation is of special importance given that several important ocular diseases such as glaucoma and age-related macular degeneration are associated with impaired autoregulation. In humans most data were collected using laser Doppler flowmetry.

The present study aims to investigate the phenomenon of transient reduction in blood flow and to gain insight in the regulatory mechanisms of optic nerve head blood flow during isometric exercise.


Eligibility criteria: Inclusion Criteria:

* Men and women aged between 18 and 35 years, nonsmokers
* Normal findings in the medical history and physical examination unless the investigator considers an abnormality to be clinically irrelevant
* Normal ophthalmic findings, ametropia less than 3 diopters

Exclusion Criteria:

* Regular use of medication, abuse of alcoholic beverages, participation in a clinical trial in the 3 weeks preceding the study
* Treatment in the previous 3 weeks with any drug (except oral contraceptives)
* Symptoms of a clinically relevant illness in the 3 weeks before the first study day
* Blood donation during the previous 3 weeks

Primary outcomes:
measure: Optic nerve head blood flow
timeFrame: 12 minutes
Secondary outcomes:
measure: Systolic/diastolic blood pressure
timeFrame: 14 minutes
measure: Intraocular pressure
timeFrame: at baseline and minute 13
measure: Pulse rate
timeFrame: 14 minutes
Other outcomes:
Locations:
city: Vienna
country: Austria
facility: Department of Clinical Pharmacology
Study officials:
affiliation: Department of Clinical Pharmacology, Medical University of Vienna
name: Gerhard Garhöfer, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03759483: Diagnostic Efficacy of CNN in Differentiation of Visual Field
Official title: Diagnostic Efficacy of Convolutional Neural Network Based Algorithm in Differentiation of Glaucomatous Visual Field From Non-glaucomatous Visual Field
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Diagnositic Efficacy of Deep Convolutional Neural Network in Differentiation of Glaucoma Visual Field From Non-glaucoma Visual Field
Keywords: Deep convolutional neural network
Visual field
Glaucoma
Lead sponsor: Sun Yat-sen University
Sponsor class: OTHER
First posted: 2018-11-30
Enrollment: 437
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients from clinics in different eye centers across China. Each subject must be diagnosed based on comprehensive medical tests and medical records. The leading center will read all the medical data to give out diagnosis as the gold standard.

Brief summary: Glaucoma is currently the leading cause of irreversible blindness in the world. The multi-center study is designed to evaluate the efficacy of the convolutional neural network based algorithm in differentiation of glaucomatous from non-glaucomatous visual field, and to assess its utility in the real world.

Detailed description: Glaucoma is the world's leading cause of irreversible blind, characterized by progressive retinal nerve fiber layer thinning and visual field defects. Visual field test is one of the gold standards for diagnosis and evaluation of progression of glaucoma. However, there is no universally accepted standard for the interpretation of visual field results, which is subjective and requires a large amount of experience. At present, artificial intelligence has achieved the accuracy comparable to human physicians in the interpretation of medical imaging of many different diseases. Previously, we have trained a deep convolutional neural network to read the visual field reports, which has even higher diagnostic efficacy than ophthalmologists. The current multi-center study is designed to evaluate the efficacy of the convolutional neural network based algorithm in differentiation of glaucomatous from non-glaucomatous visual field, compare its performance with ophthalmologists and to assess its utility in the real world.

Eligibility criteria: Inclusion Criteria:

1. Age≥18;
2. Informed consent obtained;
3. Diagnosed with specific ocular diseases;
4. Able to perform visual field test

Exclusion Criteria:

Incomplete clinical data to support diagnosis

Primary outcomes:
measure: AUC value of convolutional neural network in differentiation of Glaucoma visual field from non-glaucoma visual field
timeFrame: from Jan 2019 to Jan 2020
Secondary outcomes:
measure: Sensitivity and specificity of convolutional neural network in detection of glaucoma visual field
timeFrame: from Jan 2019 to Jan 2020
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Zhongshan Ophthalmic Center
state: Guangdong
Study officials:
References:
Clinical trial NCT05290883: Antithrombotic Activities of a Novel Yoghurt Drink: a Postprandial Study
Official title: Antithrombotic Activities of a Novel Yoghurt Drink: a Postprandial Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cardiovascular Diseases
Lead sponsor: University of Limerick
Sponsor class: OTHER
First posted: 2022-03-22
Enrollment: 5
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: The project aims to investigate the antithrombotic activity of the novel yoghurt drink enriched with polar lipids derived from ovine milk. The health claims the formulated novel or functional food on EFSA guidelines "The scientific requirements for health claims related to antioxidants, oxidative damage and cardiovascular health" and in a particular paragraph 5.4, "Claims on reduced platelet aggregation" "Platelet hyperactivity and hypercoagulability states are more commonly observed in subjects with cardiovascular (CV) risk factors. Healthy subjects or participants at very low risk of CV disease normally have non-activated circulating platelets. Reducing platelet aggregation in subjects with platelet activation during sustained exposure to the food/constituent (e.g., four weeks) would be a beneficial physiological effect".

Within this investigation, the postprandial effects of this novel yoghurt drink against platelet aggregation are going to be studied ex vivo in blood from healthy human subjects as described in previously established procedures.


Eligibility criteria: Inclusion Criteria:

* • Healthy subjects need to have their dietary and dairy intake within the range \[1-2 serves per week\]

Exclusion Criteria:

* Subjects will be excluded from the study if they are

  * Under medication and intake of dietary supplements
  * Treatment for blood clotting disorders or dyslipidaemia

Primary outcomes:
measure: An investigation of anti-platelet or antithrombotic effect of novel yoghurt drink by platelet aggregometry
timeFrame: 0 mins (preprandially) to 240 mins (postprandially)
Secondary outcomes:
Other outcomes:
Locations:
city: Limerick
country: Ireland
facility: University of Limerick
Study officials:
References:
citation: Tsoupras A, Zabetakis I, Lordan R. Platelet aggregometry assay for evaluating the effects of platelet agonists and antiplatelet compounds on platelet function in vitro. MethodsX. 2018 Dec 26;6:63-70. doi: 10.1016/j.mex.2018.12.012. eCollection 2019.
Clinical trial NCT06295783: Prospective Evaluation of the Relation Between Different Questionnaires Measuring Radiation-induced Side-effect
Official title: Prospective Evaluation of the Relation Between Different Questionnaires Measuring Radiation-induced Side-effect
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Radiation
Lead sponsor: M.D. Anderson Cancer Center
Sponsor class: OTHER
First posted: 2024-03-06
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Head and Neck Cancer (HNC) participants undergoing active radiation therapy.

Brief summary: To learn more about how you would rate the intensity or severity of your symptoms during or after radiation therapy using questionnaires with different rating scales.

Detailed description: Primary Objectives:

• To investigate how different toxicity questionnaires with different scoring systems can be reliably translated to each other by estimating different measures of correlation between items and summary scores across different questionnaires.

Eligibility criteria: Inclusion Criteria:

* Age ≥18 years
* English as a primary language
* Participants with a diagnosis of HNC undergoing active curative RT or having received curative RT within the past 5 years at MD Anderson
* Ability to complete the survey(s) of their own volition

Exclusion Criteria:

* Age \< 18 years
* Non-English speaking participants
* Participants who are receiving or have received RT in a non-HN site.
* Participants in follow up and over 5 years from post-treatment
* Neurocognitive deficits that render patients unable to complete the survey(s) on their own.

Primary outcomes:
measure: Safety and adverse events (AEs)
timeFrame: Through study completion; an average of 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Houston
country: United States
facility: MD Anderson Cancer Center
state: Texas
Study officials:
affiliation: M.D. Anderson Cancer Center
name: Amy Moreno, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06979583: Impact of Ureteral Stent and Sheaths Size on Post-Operative Pain
Official title: Impact of Ureteral Stent Size on the Management of Post Ureteroscopy Pain: a Randomized Single Blind Trial
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Ureteral Stent-Related Symptom
Retrograde Intra-renal Surgery
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
First posted: 2025-05-20
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The purpose of this study is to determine if post-operative stent size impacts stent-related pain and discomfort.


Eligibility criteria: Inclusion Criteria:

• Patients undergoing a retrograde intra-renal surgery (RIRS) (only patients undergoing the procedure for stone treatment will be included) who will require post-operative indwelling ureteral stent placement on a string at the conclusion of the procedure.

Exclusion Criteria:

* Patients with intra-operative ureteral injury who will require ureteral stent for extended time (more than 10 days, in that case a stent without a string will be used).
* Patient undergoing ureteroscopy for any indication other than stone extraction.
* Patients who are currently pregnant as determined by clinical presurgical screening.

Primary outcomes:
measure: Pain score post ureteroscopy procedure until stent removal determined by the primary operating team. Stent will be on a string
timeFrame: Starting post-operatively, daily, until stent is removed (estimated 7-14 days)
Secondary outcomes:
measure: Volume of post-operative correspondence between patients and medical system.
timeFrame: 14 days
Other outcomes:
Locations:
city: Rochester
country: United States
facility: Mayo Clinic in Rochester
state: Minnesota
Study officials:
affiliation: Mayo Clinic
name: Meghan A. Cooper, DO
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00954083: A Pilot Trial of a Developmental, Individual-Difference, Relationship-Bases (DIR)/Floortime for Children With Autistic Spectrum Disorders
Official title: A Pilot Randomized Controlled Trial of a DIR/ Floortime Parent Training Intervention for Pre-school Children With Autistic Spectrum Disorders
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Autistic Spectrum Disorders
Lead sponsor: Mahidol University
Sponsor class: OTHER
First posted: 2009-08-06
Enrollment: 32
Sex: ALL
Minimum age (years): 2
Maximum age (years): 6
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Thirty two children age 2-6 years are recruited into the study and the randomization will be stratified for chronological age and symptom severity into 2 main groups, intervention and control. The intervention group will receive an additional target treatment of DIR/Floortime parent training intervention, while the control group will continue on their routine care for 3 months.

Hypothesis: Children in the intervention group show much improvement in climbing the developmental "ladder" and declining in the autistic behaviors.


Eligibility criteria: Inclusion Criteria:

* clinical criteria for Autistic Disorders according to DSM IV
* child is 2 - 6 years of age

Exclusion Criteria:

* children with additional medical diagnosis (e.g., genetic syndromes, diagnosed hearing impairment, diagnosed visual impairment or seizures)
* children who are geographically inaccessible for follow-up visits
* their parents are not literate or known chronic psychiatric or physical illness in the parents

Primary outcomes:
measure: The Functional Emotional Assessment Scale (FEAS) Ratings (the child part)
timeFrame: at the beginning of the first session and at the 3 months follow up
Secondary outcomes:
measure: The Childhood Autism Rating Scale (CARS) Clinical rating of the children (6 point scale related to Greenspan's six Functional Development Level -FDL) Satisfaction of the effectiveness of the intervention of their child (Six-point Likert scale)
timeFrame: at the beginning of the first session and the 3 months follow up
Other outcomes:
Locations:
Study officials:
affiliation: Rehabilitation Medicine, Siriraj Hospital, Bangkok, Thailand
name: Kingkaew Pajareya, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01724983: Ketamine in Bariatric Surgery
Official title: Effects of Ketamine on Recovery From Bariatric Surgery
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE3
Conditions: Morbid Obesity
Keywords: pain
mood
depression
respiration
Lead sponsor: University of Padova
Sponsor class: OTHER
First posted: 2012-11-12
Enrollment: 90
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Ketamine may improve recovery from bariatric surgery.


Eligibility criteria: Inclusion Criteria:

* age \> 18
* obesity (Body Mass Index \> 30)
* ASA classificazion \< 4
* candidate to bariatric surgery

Exclusion Criteria:

* known or presumed pregnancy
* previous surgery on the airway, esophagus or stomach
* uncontrolled psychiatric symptomatology

Primary outcomes:
measure: pain level
timeFrame: postoperatively, up to 3 months
measure: mood level
timeFrame: postoperatively, up to 3 months
Secondary outcomes:
measure: total dosages of analgesic and muscle relaxant drugs
timeFrame: postoperatively, up to 3 months
measure: postanesthetic recovery
timeFrame: postoperatively, up to 24 hours
measure: satisfaction of the patient and of the surgeon
timeFrame: day 1
measure: pulse oximetry saturation
timeFrame: postoperatively, up to 24 hours
measure: lung volumes
timeFrame: postoperatively, up to 48 hours from end of surgery
measure: antihemetic drug dosage
timeFrame: postoperatively, up to 24 hours
measure: vasoactive drugs
timeFrame: intraoperatively and up to 24 hours from surgery end
Other outcomes:
Locations:
city: Padova
country: Italy
facility: Azienda Ospedaliera
state: PD
Study officials:
affiliation: University of Padova
name: Ulderico Freo, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01749683: Myocardial Perfusion Study to Detect Coronary Microvascular Abnormality in Diabetic Patients With Nonfatal Myocardial Infarction
Official title: Myocardial Perfusion Study to Detect Coronary Microvascular Abnormality in Diabetic Patients With Nonfatal Myocardial Infarction
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Myocardial Infarction
Lead sponsor: State University of New York - Upstate Medical University
Sponsor class: OTHER
First posted: 2012-12-17
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 71
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Diabetic and nondiabetic patients will be initially recruited and studied after acute nonfatal MI and revascularization with either PCI or CABG

Brief summary: The goal of this study is to use MCE (myocardial contrast/perfusion echocardiography) to study and compare short/long term change of myocardial perfusion abnormality and cardiac outcome in diabetic patients after nonfatal MI (heart attack), who are treated with different glucose control agents.


Eligibility criteria: Inclusion Criteria:

* Diabetic and nondiabetic patients will be initially recruited and studied after acute nonfatal MI and revascularization with either PCI or CABG

Exclusion Criteria:

* Patients are excluded if they are older than 70 year old, require mechanical ventilation, are receiving intravenous pressors or hemodynamic support, or if the motion of segments associated with infarct-related artery can not be accurately determined.

Primary outcomes:
measure: Perfusion abnormalities in nondiabetic and diabetic patients
timeFrame: short term (3 month) and long term (12 month).
Secondary outcomes:
measure: The effect of different glycemic control strategies on the reduction of coronary injury in diabetic and non-diabetic subjects
timeFrame: short term (3 month) and long term (12 month)
Other outcomes:
Locations:
city: Syracuse
country: United States
facility: SUNY Upstate Medical University
state: New York
Study officials:
References: