Clinical trial NCT02674659: The Effect of Resistance Training on Proprotein Subtilisin Convertase Kexin 9 Level After Coronary Bypass Surgery
Official title: The Effect of Resistance Training on Proprotein Subtilisin Convertase Kexin 9 (PCSK-9) Level in Patients After Coronary Bypass Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Coronary Artery Disease
Keywords: resistance training, PCSK9, coronary artery bypass grafting
Lead sponsor: National Cardiovascular Center Harapan Kita Hospital Indonesia
Sponsor class: OTHER
First posted: 2016-02-04
Enrollment: 87
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: This research add resistance training to patients who undergo cardiac rehabilitation program after coronary bypass surgery, comparing the level of PCSK9 level on that group to another group who receives conventional rehabilitation program (only aerobic exercise)

Detailed description: The PCSK9 level measured before and after cardiac rehabilitation program (around 3-4 weeks), and compared between two groups. ELISA method will be used to measure plasma PCSK9 level.

Resistance training will be given by professional trainer in gymnasium of National Cardiovascular Center Harapan Kita supervised by cardiologists, following rules from American College of Sports Medicine guideline regarding to exercise after cardiac event.

Eligibility criteria: Inclusion Criteria:

* post elective coronary artery bypass surgery
* \> 18 years old
* sign informed consent

Exclusion Criteria:

* contraindications of resistance training (unstable angina, uncontrolled blood pressure (systolic \> 160 mmHg diastolic \> 100 mmHg), acute heart failure, pulmonary diseases, arrhythmia malignant)
* musculoskeletal pain, visual analog scale \>3
* post congenital heart disease surgery
* post elective coronary artery bypass surgery with malfunction valves (operated or not)

Primary outcomes:
measure: PCSK-9 Level
timeFrame: 3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program)
Secondary outcomes:
measure: Low Density Lipoprotein
timeFrame: 3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program)
measure: Body Mass Index
timeFrame: 3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program)
measure: High-Density Lipoprotein
timeFrame: 3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program)
measure: Total Cholesterol
timeFrame: 3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program)
measure: Triglyceride
timeFrame: 3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program)
measure: Fasting Blood Glucose
timeFrame: 3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program)
measure: Systolic Blood Pressure
timeFrame: 3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program)
measure: Diastolic Blood Pressure
timeFrame: 3-4 weeks (after completion of 12 sessions of cardiac rehabilitation program)
Other outcomes:
Locations:
Study officials:
affiliation: National Cardiovascular Center Harapan Kita
name: Bambang Dwiputra, MD
role: PRINCIPAL_INVESTIGATOR
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