louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02361632: Does Adding Milk to Coffee Change Gastric Volume?
Official title: Does Adding Milk to Coffee Change Gastric Volume?
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Respiratory Aspiration of Gastric Content
Lead sponsor: University of Aarhus
Sponsor class: OTHER
Collaborators: name: Aarhus University Hospital Skejby
First posted: 2015-02-12
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The intention of this study is to determine wether coffee added milk change gastric volume in comparison with gastric volume after drinking black coffee

Detailed description: Thirty participants - divided in tree groups - drink coffee with or without milk after six hours fast for solid food. Each group drinks both coffee with or without milk in different order. Two hours after drinking coffee gastric volume is measured by Magnetic Resonance Imagining.

Eligibility criteria: Inclusion Criteria:

* Healthy volunteers

Exclusion Criteria:

* Former or present gastric history, pregnancy, claustrophobia, metal implants

Primary outcomes:
measure: Change in gastric volume after 175 ml coffee with 20% full fat milk compared with gastric volume after 175 ml black coffee .
timeFrame: "Up to 1 year" asses and proces
Secondary outcomes:
measure: Change in gastric volume after 175 ml coffee with 50% full fat milk compared with gastric volume after 175 ml black coffee
timeFrame: "Up to 1 year" asses and proces
Other outcomes:
Locations:
Study officials:
affiliation: Aarhus University Hospital Skejby
name: Karin T Beier, MEd
role: STUDY_CHAIR
References:
citation: Larsen B, Larsen LP, Sivesgaard K, Juul S. Black or white coffee before anaesthesia?: A randomised crossover trial. Eur J Anaesthesiol. 2016 Jun;33(6):457-62. doi: 10.1097/EJA.0000000000000457.
Clinical trial NCT01638832: Association of Non-alcoholic Fatty Liver Disease and Coronary Artery Disease
Official title: Association of Non-alcoholic Fatty Liver Disease and Coronary Artery Disease
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Nonalcoholic Steatohepatitis (NASH)
Keywords: NASH; coronary artery disease
Lead sponsor: Johann Wolfgang Goethe University Hospital
Sponsor class: OTHER
First posted: 2012-07-12
Enrollment: 572
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: This study will evaluate the association of non-alcoholic fatty liver disease and coronary artery disease. All patients presenting for coronary angiogram will receive the following examination:

* Transient Elastography and Controlled Attenuation Parameter using the FibroScan
* blood examination including biochemical markers The results of non-invasive liver steatosis and fibrosis measurement are compared with the results of coronary angiogram concerning the presence or absence of coronary artery disease.


Eligibility criteria: Inclusion Criteria:

* Male or female, 18 years and older
* Written consent
* Coronary angiogram planned

Exclusion Criteria:

* Patients with mental diseases
* Pregnancy or lactation
* Ascites

Primary outcomes:
measure: Liver fibrosis scores I-IV (METAVIR)
Secondary outcomes:
measure: Steatosis fibrosis scores I-III
Other outcomes:
Locations:
city: Frankfurt am Main
country: Germany
facility: Klinikum der J. W. Goethe-Universität
Study officials:
affiliation: Klinikum der J. W. Goethe-Universität Frankfurt am Main
name: Mireen Friedrich-Rust, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01057732: Effects of Parathyroidectomy on Cardiovascular Risk Factors in Primary Hyperparathyroidism
Official title: The Effect of Parathyroidectomy on Cardiovascular Risk Factors in Patients With Primary Hyperparathyroidism
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Primary Hyperparathyroidism
Lead sponsor: HaEmek Medical Center, Israel
Sponsor class: OTHER
First posted: 2010-01-27
Enrollment: 76
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with Primary hyperparathyroidism referred to Endocrine clinic. Controls recruited in community-based health centers.

Brief summary: Primary hyperparathyroidism (PHPT) is associated with increased cardiovascular morbidity. The benefit of surgical treatment in this respect is unclear.

This study was performed to evaluate the impact of parathyroidectomy (PTX) on cardiovascular risk profile.

Detailed description: Patients with primary hyperparathyroidism (PHPT) have been shown to have an increased morbidity and mortality mainly due to cardiovascular disease. The precise mechanism of cardiovascular disease in PHPT is not well understood and probably multifactorial. Functional or structural alterations of vascular endothelial and smooth muscle cells may impair the vascular reactivity and lead to accelerated atherogenesis. Several cardiovascular risk factors such as obesity, hypertension, insulin resistance and hyperlipidemia are more prevalent in PHPT compared with controls.Patients with severe form of PHPT had a greater probability of metabolic syndrome (MS) and insulin resistance than patients with mild PHPT and eucalcemic subjects. Although the excess in cardiovascular mortality is significantly and independently related to serum calcium, the connection between the biochemical disturbances and the cardiovascular disorders in PHPT patients is not necessarily a cause-and-effect relationship. Indeed, the impact of surgical cure of hyperparathyroidism on cardiovascular risk factors and mortality is controversial. Some studies suggest that hypertension, dyslipidemia, and derangement of glucose metabolism improve after removal of overactive parathyroid tissue. Others have shown that cardiovascular risk markers remained unaltered after parathyroidectomy (PTX).

The aim of this study was to evaluate whether successful PTX is associated with decreased cardiovascular risk. We investigated indices of metabolic syndrome and insulin resistance as well as various cardiovascular risk factors in patients with manifest PHPT before and one year after successful PTX.

Eligibility criteria: Inclusion Criteria:

* Patients with primary hyperparthyroidism

Exclusion Criteria:

* Individuals with known diabetes mellitus,coronary heart disease, stroke

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Afula
country: Israel
facility: Endocrine Institute, Haemek Medical Center
Study officials:
References:
Clinical trial NCT00000232: Alternate Day Buprenorphine Administration, Phase IX - 14
Official title: Alternate Day Buprenorphine Administration, Phase IX
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Opioid-Related Disorders
Lead sponsor: University of Vermont
Sponsor class: OTHER
Collaborators: name: National Institute on Drug Abuse (NIDA)
First posted: 1999-09-21
Enrollment: 0
Sex: ALL
Minimum age (years): 22
Maximum age (years): 51
Standard ages: ADULT
Accepts healthy volunteers: no
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine if four times a subjects' daily maintenance dose will hold for 120 hours without changes in agonist and antagonist effects.


Eligibility criteria: Please contact site for information.

Primary outcomes:
measure: Drug use
measure: Opioid withdrawal
measure: Opioid agonist effects
measure: Dose identification
measure: Pupil diameter
Secondary outcomes:
Other outcomes:
Locations:
city: Burlington
country: United States
facility: Treatment Research Center
state: Vermont
Study officials:
affiliation: University of Vermont
name: Warren Bickel, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00579332: Effects of Brassica or Indole-3-carbinol on Prostatectomy Patients With PSA Recurrence
Official title: Effects of Brassica or Indole-3-Carbinol on Prostatectomy Patients With PSA Recurrenc
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
PHASE3
Conditions: Biochemical Failure
Keywords: PSA
biochemical failure
Lead sponsor: Vanderbilt University
Sponsor class: OTHER
Collaborators: name: American Institute of Cancer Prevention
First posted: 2007-12-24
Enrollment: 16
Sex: MALE
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Pilot and feasibility diet and phyto-agent intervention among healthy men at risk for prostate cancer progression.


Eligibility criteria: Inclusion Criteria:

* Men with PSA recurrence following prostatectomy

Exclusion Criteria:

* Not using exogenous hormones

Primary outcomes:
measure: change in blood PSA levels
timeFrame: 6 months
Secondary outcomes:
measure: monitor for health events
timeFrame: 6 months
Other outcomes:
Locations:
city: Nashville
country: United States
facility: Vanderbilt_University
state: Tennessee
Study officials:
affiliation: Vanderbilt University
name: Jay H Fowke, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02837432: The Effect of Cortisol Administration on Neural Correlates of Emotion in Depression
Official title: The Effect of Cortisol Administration on Neural Correlates of Emotion in Depression
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: EARLY_PHASE1
Conditions: Depression
Keywords: Depression
Cortisol
Sadness
Genetics
Stress
Lead sponsor: Stanford University
Sponsor class: OTHER
First posted: 2016-07-19
Enrollment: 192
Sex: ALL
Minimum age (years): 21
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: There is good evidence to suggest that the pathological version of sadness that people with Major Depression experience could be caused by the failure of the hormone cortisol to properly inhibit sadness-related brain activity in the subgenual cingulate cortex. This project investigates if the subgenual cingulate cortex has become insensitive to cortisol in patients with depression and tests for variants of the cortisol receptor genes that could predispose individuals to develop cortisol insensitivity.


Eligibility criteria: https://redcap.stanford.edu/surveys/?s=3F7WCENPND

Inclusion Criteria:

* Healthy Participants must have no Axis 1 mental disorder
* Participants with depression must meet minimum severity levels (Hamilton \>7)
* All participants must weight less than 280 pounds for the purposes of MRI scanning

Exclusion Criteria:

In order to protect against risk associated with taking Hydrocortisone, all participants must not have any of the following:

* Psychotropic medications
* Recent surgery
* Endocrine disorders
* Liver disease
* Kidney disease
* Thyroid disorder
* History of malaria
* Tuberculosis
* Osteoporosis
* Glaucoma/cataracts
* Chronic expressed infections (herpes --including ocular herpes, HIV, etc.)
* History of congestive heart failure
* History of recurring seizures
* Stomach Ulcers
* Comorbid psychosis
* Current use of illicit drugs
* High Blood pressure

In order to protect against risks associated with MRI scanning participants must not be/have any of the following:

* \>280 lbs
* In-dwelling ferrous metals
* Left Handed
* Abnormal Hearing
* Claustrophobic
* Head injury with loss of consciousness

Primary outcomes:
measure: Sadness-induced subgenual cingulate activity as measured by functional magnetic resonance imaging.
timeFrame: 2 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Stanford
country: United States
facility: Department of Psychiatry and Behavioral Sciences, 401 Quarry Road
state: California
Study officials:
affiliation: Stanford University
name: Keith Sudheimer, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04379232: Surgical Activity During the Covid-19 Pandemic: Results for 112 Patients in a French Tertiary Care Center
Official title: Surgical Activity During the Covid-19 Pandemic: Results for 112 Patients in a French Tertiary Care Center: A Retrospective Observational Cohort Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Digestive Cancer
Gynaecological Cancer
Head and Neck Cancer
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2020-05-07
Enrollment: 112
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Every patient operated on during Covid pandemic at Croix-Rousse Hospital, hospices civils de Lyon, Lyon, France

Brief summary: Background

After the emergence of Covid-19 in China, Hubei Province, the epidemic quickly spread to Europe. France was quickly hit and the Croix-Rousse hospital at the Hospices Civils de Lyon was one of the first French university hospital to receive patients infected with Sars-COV2. The predicted massive influx of patients motivated the cancellation of all elective surgical procedures planned to free hospitalization beds and to free intensive care beds. Nevertheless, patients who had to be canceled had to be properly selected to avoid a life threatening. The retained surgical indications were surgical emergencies, oncologic surgery and organ transplantation.

The objective was to describe the organization of the Croix-Rousse hospital to allow the continuation of these surgical activities while limiting the exposure of patients to the Sars Cov2.


Eligibility criteria: Inclusion Criteria:

* surgical management
* \> 18 years old

Exclusion Criteria:

* \< 18 years old

Primary outcomes:
measure: Symptoms of Covid after surgery
timeFrame: Screening test are performed if the patient becomes symptomatic up to 14 days after surgery. In case of symptoms patients are tested within 24 hours.
Secondary outcomes:
Other outcomes:
Locations:
city: Lyon
country: France
facility: Croix-Rousse Hospital, Hospices Civils de Lyon
Study officials:
References:
Clinical trial NCT01276132: Patient Satisfaction and Safety Outcomes After Enrollment in a Same-Day (SD) Percutaneous Coronary Intervention Program
Official title: Patient Satisfaction and Safety Outcomes After Enrollment in a Same-Day (SD) Percutaneous Coronary Intervention Program
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: To Evaluate Clinical Outcomes, Safety, and Satisfaction of Patients Who Have Participated in a Same Day Outpatient Percutaneous Coronary Artery Intervention
Keywords: percutaneous coronary artery intervention
coronary disease
Lead sponsor: University of Chicago
Sponsor class: OTHER
First posted: 2011-01-13
Enrollment: 59
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Every patient who presents to the Cardiac Catheterization Laboratory for coronary angiography will be given the opportunity to participate in this program. The determination on whether or not a patient is selected to undergo Same-Day PCI is based on the clinical decision of the practicing physician according to conventionally accepted inclusion and exclusion criteria. The decision on whether or not to participate in the questionnaire study will not affect any treatment decisions. The only exclusion criteria will be if the patient declines participation. The investigators would like to enroll 250 patients over a three year period.

Brief summary: Subjects in this study have recently had or are scheduled for a (percutaneous coronary intervention) PCI as part of their normal, routine medical care. This procedure should restore the blood flow in the vessels of the heart.

Recent studies have shown that stable patients who undergo PCI and are discharged home after 4 hours of observation do not suffer any more complications compared to patients who stay in the hospital overnight. In addition, studies suggest that patients express increased satisfaction at being discharged after 4 hours.

The University of Chicago is one of the first US medical centers to institute a formal program of same-day discharge after PCI. This study will seek, through a analysis of medical information and satisfaction questionnaires, to assess whether this particular same-day discharge program can improve patient satisfaction and preserve patient safety.


Eligibility criteria: Inclusion Criteria:

* age 18 and up
* undergoes coronary angiography in the Cardiac Catheterization Laboratory

Exclusion Criteria:

* if the subject declines participation

Primary outcomes:
measure: To evaluate clinical outcomes, safety, and satisfaction of patients who have participated in a same-day outpatient percutaneous coronary artery intervention program
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Chicago
country: United States
facility: University of Chicago Medical Center
state: Illinois
Study officials:
affiliation: University of Chicago
name: Atman Shah, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01120132: Study Evaluating the Efficacy of Administration of Cyclosporine (Low Dose and High Dose) and Prednisolone Acetate Compared to Its Components and Vehicle in Patients With Allergic Conjunctivitis
Official title: A Multi-Center, Randomized, Double-Masked Evaluation of the Efficacy of Administration of FOV1101-00 (Cyclosporine Low Dose and High Dose) and Prednisolone Acetate Compared to Its Components and Vehicle in Patients With Mild Ongoing Ocular Allergic Inflammation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Allergic Conjunctivitis
Lead sponsor: Fovea Pharmaceuticals SA
Sponsor class: INDUSTRY
First posted: 2010-05-10
Enrollment: 716
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine the efficacy and safety of the administration of cyclosporine and prednisolone acetate compared to placebo in the treatment of allergic conjunctivitis.


Eligibility criteria: Inclusion Criteria:

* history of ocular allergies and a positive skin test reaction to perennial allergens within the past 24 months and a history of chronic eye irritation
* visual acuity score ≥ 0.60 (EDTS)
* negative urine pregnancy test for female patients, and use of adequate birth control throughout the study period.

Exclusion Criteria:

* active ocular infection; preauricular lymphadenopathy or ocular condition that could affect study; glaucoma or abnormal intraocular pressure; ocular surgery within past 3 months; history of asthma, pregnancy or nursing
* contraindications or known allergies to the study drug(s)

Primary outcomes:
measure: Diary assessment of signs and symptoms of ocular allergy
timeFrame: During the 28 days of treatment
Secondary outcomes:
measure: Diary and office assessments of various ocular and nasal allergy signs and symptoms
timeFrame: During 28 days of treatment
measure: Safety
timeFrame: During the 28 days of treatment
Other outcomes:
Locations:
city: Andover
country: United States
facility: ORA
state: Massachusetts
Study officials:
affiliation: Fovea Pharmaceuticals SA
name: Marie-Louise Jacques, MD MBA
role: STUDY_CHAIR
References:
Clinical trial NCT05947032: Supervised Endurance Training Among Pulmonary Arterial Hypertension Patients
Official title: Effects of Supervised Endurance Training Versus Home-based Exercise Plan on Functional Capacity and Fatigue Among Pulmonary Arterial Hypertension Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pulmonary Arterial Hypertension
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2023-07-14
Enrollment: 50
Sex: ALL
Minimum age (years): 20
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To compare the effects of supervised endurance training versus home based exercise plan on functional capacity and fatigue among pulmonary arterial hypertension patients.


Eligibility criteria: Inclusion Criteria:

* Patients with pulmonary arterial hypertension, not pregnant and tobacco free.
* Age = 21 to 82
* Patients with documented PAH diagnosed by echocardiography (enlarged RA an enlarged RV with a thick wall, septal shift by enlarged chambers of right side of heart, an elevated mPAP) or a resting mean pulmonary arterial pressure equal to 25mm Hg determined by right heart catheterization.
* Patients on stable PH therapies, sedentary, and had no pulmonary rehabilitation for 6 months prior to enrolment.

Exclusion Criteria:

* Patients will be excluded if they are not able to complete 6MWT.
* A documented pulmonary capillary wedge pressure greater then or equal to 15 mm Hg.
* Significant hepatic, renal, metabolic or mitochondrial dysfunctions; severe psychiatric disease; use of beta-adrenergic blockers or antiretroviral therapies; and any musculoskeletal or neurological condition that would limit walking or exercise performance.
* Patients with a history of heart failure.

Primary outcomes:
measure: Fatigue Severity Scale
timeFrame: 4 weeks
measure: Human Activity Profile
timeFrame: 4 weeks
measure: 6MWT Distance
timeFrame: 4 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Peshawar
country: Pakistan
facility: Lady Reading hospital
state: Khyber Pakhtunkhwa
Study officials:
affiliation: Riphah International University
name: Muhammad Iqbal Tariq, PhD*
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01732432: Endometriosis and Frequency of Endometriosis-associated Ovarian Carcinomas (EAOC)
Official title: Endometriosis and Frequency of Endometriosis-associated Ovarian Carcinomas (EAOC) - Epidemiological and Molecular Pathological Aspects
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Endometrioid Carcinoma
Clear Cell Carcinoma
Endometriosis
Lead sponsor: University Hospital, Basel, Switzerland
Sponsor class: OTHER
First posted: 2012-11-22
Enrollment: 0
Sex: FEMALE
Minimum age (years): 30
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: primary care hospital, university hospital

Brief summary: The purpose of this study is to determine whether a relationship exists between a previously established diagnosis of endometriosis and the consecutive risk of developing a clear cell or endometrioid ovarian carcinoma. All histopathological records since 1980 with these diagnoses (endometriosis, clear cell and endometrioid ovarian carcinoma) will be reviewed. Cancer registry data will be assessed to investigate differences in survival of women with endometriosis-associated ovarian carcinomas and those ovarian carcinoma patients without previous diagnosis of endometriosis.


Eligibility criteria: Inclusion Criteria:

* endometrioid ovarian carcinoma
* clear cell ovarian carcinoma
* endometriosis, atypical endometriosis
* borderline tumors with endometriosis

Exclusion Criteria:

* undifferentiated carcinomas
* germ cell tumors
* sex cord-stromal tumors

Primary outcomes:
measure: incidence and clinical outcome of endometriosis-associated ovarian carcinomas
timeFrame: 30 years
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: University Hospital Basel, University of Basel
name: Ellen Obermann, MD, Dr.
role: PRINCIPAL_INVESTIGATOR
affiliation: Institute of Pathology, University Hospital Basel, University of Basel
name: Ellen C Obermann, MD
role: PRINCIPAL_INVESTIGATOR
References: