Clinical trial NCT06760728: Inappropriate Prescribing in the Elderly
Official title: Multicenter Observational Study on the Prevalence of Inappropriate Prescribing in Elderly Patients At Admission and Discharge from a Hospital Ward Using the STOPP/START Criteria
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Prescriptions
Elderly (people Aged 65 or More)
Hospitalized
Prevalence
Keywords: polypharmacotherapy
medication review
Drug interactions
elderly patients
deprescribin
STOPP/START criteria
of potentially inappropriate prescriptions (PIPs)
potential omitted prescriptions (PPOs)
PIPs
POPs
Hospital
Lead sponsor: Regione del Veneto - AULSS n. 7 Pedemontana
Sponsor class: OTHER
Collaborators: name: Azienda Ospedaliera Universitaria Integrata Verona
First posted: 2025-01-07
Enrollment: 100
Sex: ALL
Minimum age (years): 70
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients aged ≥ 70 years admitted to a geriatric ward, regardless of ethnicity, gender, or type of illness, will also be considered eligible for enrollment.

Brief summary: The management of pharmacotherapy in elderly patients is an increasingly critical aspect, as polypharmacy, combined with the pharmacokinetic and pharmacodynamic changes typical of aging, makes older adults more sensitive to the development of adverse reactions. This highlights the importance of appropriate use of pharmacotherapy that considers the risks and benefits of individual treatments. The aim of this study is to measure the prevalence of pharmacological appropriateness using the STOPP/START criteria (version 2) at admission and discharge from an acute geriatric ward, thereby evaluating the impact of hospitalization on medication prescribing.


Eligibility criteria: Inclusion Criteria:

* Patients aged ≥ 70 years admitted to a geriatric ward
* Regardless of ethnicity, gender, or type of illness
* Patients transferred from another ward
* Patients admitted to another ward for support

Exclusion Criteria:

• Patients in the terminal phase (\<6 months life expectancy)

Criteria for exit from the study (Dropout):

* Patients transferred to another hospital ward
* Patients who have deceased

Primary outcomes:
measure: Prevalence of inappropriate prescribing in elderly patients at admission to an acute care hospital using STOPP/START criteria
timeFrame: Data collected at time Day 0 is analyzed by day 4. Data collected at time Day 1 is analyzed by day 4
Secondary outcomes:
measure: Prevalence of inappropriate prescribing in elderly patients at discharge from an acute care hospital using STOPP/START criteria.
timeFrame: Data collected at time Day 0 is analyzed by day 4. Data collected at time Day 1 is analyzed by day 4
measure: Percentage of cases in which inappropriate prescribing will be detected at admission and discharge
timeFrame: Data collected at time Day 0 is analyzed by day 4. Data collected at time Day 1 is analyzed by day 4
measure: Association between the prevalence of inappropriate prescriptions and clinical variables, measured using univariate and multivariate regression.
timeFrame: Data collected at time Day 0 is analyzed by day 4. Data collected at time Day 1 is analyzed by day 4
Other outcomes:
Locations:
city: Santorso
country: Italy
facility: Regione del Veneto - AULSS n. 7 Pedemontana
state: Vicenza
Study officials:
affiliation: Regione del Veneto - AULSS n. 7 Pedemontana
name: Luca Pellizzari Dr. Pellizzari, DR
role: PRINCIPAL_INVESTIGATOR
References: