Clinical trial NCT00799877: Chronic Plaque Psoriasis (Ps) Registry
Official title: A 10-Year, Post-marketing, Observational Study to Assess Long Term Safety of HUMIRA® (Adalimumab) in Adult Patients With Chronic Plaque Psoriasis (PS)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Chronic Plaque Psoriasis
Keywords: Psoriasis
Moderate Psoriasis
Severe Psoriasis
Chronic Plaque Psoriasis
Severe Chronic Plaque Psoriasis
Registry
Lead sponsor: AbbVie
Sponsor class: INDUSTRY
First posted: 2008-12-01
Enrollment: 6065
Sex: ALL
Minimum age (years): 18
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: primary care clinic, departments of dermatology

Brief summary: The purpose of this study is to evaluate the long-term safety of Humira® in Adult Patients with Chronic Plaque Psoriasis (Ps).

Detailed description: ESPRIT is a 10 year registry of patients taking HUMIRA® for Psoriasis. Patients who volunteer to participate will be asked to provide information about their medical history and experiences with HUMIRA®. No registry specific testing will be performed. Patients will be asked to provide data on their experiences with HUMIRA® approximately every 6 months, or as determined by the study doctor. No drug will be provided as a result of participation in the registry. All treatment decisions are independent of participation in the registry.

Eligibility criteria: Inclusion Criteria:

1. An adult patient (18 years of age or older) with chronic plaque psoriasis who has been prescribed HUMIRA® therapy according to the local product labeling and meets one of the following criteria:

   * New initiated (within 4 weeks of registry entry) on HUMIRA® therapy;
   * Initiated HUMIRA® therapy in the past and:

     * Has received continuous (no more than 70 consecutive days off drug) HUMIRA® therapy and the physician can provide source documentation of SAEs, AEs, of Special Interest, and dosing information since initiation of therapy.

   OR
   * Is entering after participation in an AbbVie HUMIRA (adalimumab) sponsored study and has received continuous (no more than 70 consecutive days off drug) HUMIRA® therapy after the completion of AbbVie sponsored study and physician can provide source documentation of SAEs, AEs of Special Interest, and dosing information since initiation of commercial HUMIRA® (defined as a prescribed/non study drug).
2. Patient is willing to consent to data being collected and provided to AbbVie;
3. Patient is capable of and willing to give written informed consent and to comply with the requirements of the registry.

Exclusion Criteria:

- Patient should not be enrolled if he/she cannot be treated in accordance with the local product label.

Primary outcomes:
measure: Incidence of Serious Adverse Events
timeFrame: Duration of study
measure: Incidence of Adverse Events of Special Interest
timeFrame: Duration of study
measure: Adverse Events that lead to permanent discontinuation of HUMIRA®
timeFrame: Duration of study
Secondary outcomes:
measure: Health Care Utilization
timeFrame: Duration of study
measure: Work Productivity and Activity Impairment Questionnaire: Specific Health Problem
timeFrame: Duration of study
measure: Patient Global Assessment
timeFrame: Duration of study
measure: Patient Health Question-9
timeFrame: Duration of study
measure: Medical Outcomes Social Activities Scale
timeFrame: Duration of study
measure: Patient reported outcome - Dermatology Life Quality Index
timeFrame: Duration of study
measure: Census
timeFrame: Duration of study
measure: Psoriasis Impact and Experience
timeFrame: Duration of study
measure: Illness Cognition
timeFrame: Duration of study
measure: Insurance Status
timeFrame: Duration of study
measure: Rosenberg Self-Esteem Scale
timeFrame: Duration of study
measure: Physician's Global Assessment
timeFrame: Collected approximately every six months.
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: Southview Medical Group, PC /ID# 20961
state: Alabama
city: Birmingham
country: United States
facility: Total Skin and Beauty Derm Ctr /ID# 17156
state: Alabama
city: Birmingham
country: United States
facility: Inverness Dermatology /ID# 76194
state: Alabama
city: Birmingham
country: United States
facility: McLain Medical Associates, PC /ID# 18351
state: Alabama
city: Daphne
country: United States
facility: Deep South Dermatology, PC /ID# 40267
state: Alabama
city: Huntsville
country: United States
facility: Northeast Alabama Dermatology /ID# 76193
state: Alabama
city: Huntsville
country: United States
facility: Yates, Huntsville, AL /ID# 17130
state: Alabama
city: Mobile
country: United States
facility: Mobile Dermatology, P.C. /ID# 19783
state: Alabama
city: Phoenix
country: United States
facility: Medical Dermatology Specialist /ID# 76113
state: Arizona
city: Phoenix
country: United States
facility: Arizona Advanced Dermatology /ID# 20512
state: Arizona
city: Phoenix
country: United States
facility: Camelback Dermatology & Skin Surgery /ID# 18901
state: Arizona
city: Phoenix
country: United States
facility: Alliance Dermatology and MOHs Center, PC /ID# 17087
state: Arizona
city: Phoenix
country: United States
facility: Omni Dermatology Research /ID# 135562
state: Arizona
city: Scottsdale
country: United States
facility: Affiliated Dermatology /ID# 18327
state: Arizona
city: Tucson
country: United States
facility: Specialists in Dermatology /ID# 18864
state: Arizona
city: Fort Smith
country: United States
facility: Johnson Dermatology Clinic /ID# 17088
state: Arkansas
city: Rogers
country: United States
facility: Hull Dermatology, PA /ID# 17086
state: Arkansas
city: Danville
country: United States
facility: Elite MD Adv Derm Laser /ID# 28323
state: California
city: Fremont
country: United States
facility: Center for Dermatology Clinical Research /ID# 20722
state: California
city: Fresno
country: United States
facility: Associates in Research /ID# 17544
state: California
city: Garden Grove
country: United States
facility: Dermatology and Dermatologic /ID# 17145
state: California
city: Glendale
country: United States
facility: Guagenti, Glendale, CA /ID# 28263
state: California
city: La Jolla
country: United States
facility: Miremadi Dermatology /ID# 24323
state: California
city: La Mesa
country: United States
facility: SCRIPPS Clinic /ID# 28147
state: California
city: Lodi
country: United States
facility: Dr. Abdallah Khourdaji /ID# 24307
state: California
city: Long Beach
country: United States
facility: Premiere Clinical Research,LLC /ID# 44719
state: California
city: Los Angeles
country: United States
facility: Kaiser Permanente LA Med Ctr /ID# 24334
state: California
city: Los Angeles
country: United States
facility: Dermatology Research Associates /ID# 17158
state: California
city: Mountain View
country: United States
facility: California Skin Institute /ID# 19769
state: California
city: Northridge
country: United States
facility: Quest Dermatology Research /ID# 71677
state: California
city: Oxnard
country: United States
facility: Dermatology Medical Group of Oxnard /ID# 17102
state: California
city: San Francisco
country: United States
facility: Univ California, San Francisco /ID# 28267
state: California
city: San Gabriel
country: United States
facility: Danesh, San Gabriel, CA /ID# 23068
state: California
city: San Jose
country: United States
facility: Carson, San Jose, CA /ID# 17064
state: California
city: San Ramon
country: United States
facility: East Bay Psoriasis Trmnt Ctr /ID# 17081
state: California
city: Santa Rosa
country: United States
facility: Redwood Family Dermatology /ID# 76119
state: California
city: Upland
country: United States
facility: Skin Physicians & Surgeons Med /ID# 40265
state: California
city: Valencia
country: United States
facility: Advanced Dermatology & Cosmetic Care /ID# 20511
state: California
city: Vallejo
country: United States
facility: Solano Dermatology Associates /ID# 20727
state: California
city: Colorado Springs
country: United States
facility: Colorado Springs Derm Clinic /ID# 28165
state: Colorado
city: Longmont
country: United States
facility: Skin Care Specialists of CO /ID# 17142
state: Colorado
city: Bridgeport
country: United States
facility: Moss and Maiocco, MD, LLC /ID# 69767
state: Connecticut
city: Danbury
country: United States
facility: Notaro, Danbury, CT /ID# 40264
state: Connecticut
city: Danbury
country: United States
facility: Derm Assoc of Western CT /ID# 71673
state: Connecticut
city: New Haven
country: United States
facility: Choi, New Haven, CT /ID# 58982
state: Connecticut
city: Newark
country: United States
facility: Panzer Dermatology & Cosmetic /ID# 17131
state: Delaware
city: Newark
country: United States
facility: Panzer Dermatology & Cosmetic /ID# 17146
state: Delaware
city: Washington
country: United States
facility: George Washington University Hospital /ID# 24270
state: District of Columbia
city: Aventura
country: United States
facility: Private Practice- Dr. Tory Sullivan /ID# 17126
state: Florida
city: Celebration
country: United States
facility: Dermatology and Skin Surgery /ID# 88353
state: Florida
city: Coral Gables
country: United States
facility: Florida Academic Centers Research and Education /ID# 24273
state: Florida
city: Delray Beach
country: United States
facility: Dermatology Associates of the Palm Beaches /ID# 17137
state: Florida
city: Fort Lauderdale
country: United States
facility: Ft. Lauderdale Derm & Cosmetic /ID# 23071
state: Florida
city: Hollywood
country: United States
facility: Hollywood Dermatology /ID# 17129
state: Florida
city: Hollywood
country: United States
facility: Hollywood Dermatology /ID# 19771
state: Florida
city: Lecanto
country: United States
facility: Suncoast Dermatology and Skin Surgery Center /ID# 23067
state: Florida
city: Miami
country: United States
facility: Athenea Assoc Med Research /ID# 69768
state: Florida
city: Naples
country: United States
facility: Assoc. in Med & Surg Derm /ID# 17523
state: Florida
city: Orlando
country: United States
facility: Central Florida Dermatology Associates /ID# 20508
state: Florida
city: Panama City
country: United States
facility: Gulf Coast Dermatology /ID# 20724
state: Florida
city: Pembroke Pines
country: United States
facility: Snyder, Pembroke Pines, FL /ID# 17122
state: Florida
city: Pinellas Park
country: United States
facility: Gary L. Heller - Dermatology Research Cosmetic Center /ID# 17083
state: Florida
city: Plantation
country: United States
facility: Skin and Cancer Associates /ID# 20726
state: Florida
city: Sarasota
country: United States
facility: The Center for Skin Wellness /ID# 42005
state: Florida
city: Stuart
country: United States
facility: Water's Edge Dermatology - Stuart /ID# 76114
state: Florida
city: Tampa
country: United States
facility: Scannon, Tampa, Florida /ID# 28160
state: Florida
city: Tampa
country: United States
facility: University of South Florida /ID# 38289
state: Florida
city: Tampa
country: United States
facility: Ctr for Derm & Skin Surgery /ID# 28210
state: Florida
city: Tampa
country: United States
facility: Geisinger Medical Center /ID# 17521
state: Florida
city: Venice
country: United States
facility: Coast Derm & Skin Cancer Ctr /ID# 40189
state: Florida
city: Vero Beach
country: United States
facility: Heskel, Vero Beach, FL /ID# 69764
state: Florida
city: Alpharetta
country: United States
facility: Hamilton Research, LLC /ID# 20503
state: Georgia
city: Atlanta
country: United States
facility: Parker, Atlanta, GA /ID# 40190
state: Georgia
city: Calhoun
country: United States
facility: Skin Cancer & Cosmetic Derm Ct /ID# 23313
state: Georgia
city: Conyers
country: United States
facility: East Metro Dermatology PC /ID# 20505
state: Georgia
city: Macon
country: United States
facility: Dermatologic Surgery Specialis /ID# 17149
state: Georgia
city: Marietta
country: United States
facility: NW GA Dermatology & Skin Cancer Specialists /ID# 17089
state: Georgia
city: Marietta
country: United States
facility: Paula Nelson MD & Associates /ID# 23076
state: Georgia
city: Newport
country: United States
facility: RI Dermatology & Cosmetic Ctr /ID# 40270
state: Georgia
city: Rome
country: United States
facility: Skin Cancer & Cosmetic Derm /ID# 24305
state: Georgia
city: Rome
country: United States
facility: Northwest Georgia Dermatology /ID# 28162
state: Georgia
city: Tucker
country: United States
facility: Atlanta Derm & Laser Surgery /ID# 28144
state: Georgia
city: Blackfoot
country: United States
facility: Wray, Blackfoot, ID /ID# 24333
state: Idaho
city: Chubbuck
country: United States
facility: Idaho Skin Institute /ID# 76118
state: Idaho
city: Nampa
country: United States
facility: Saltzer Medical Group /ID# 17144
state: Idaho
city: Twin Falls
country: United States
facility: Olmstead, Twin Falls, ID /ID# 24325
state: Idaho
city: Chicago
country: United States
facility: Pinski Dermatology /ID# 17147
state: Illinois
city: Chicago
country: United States
facility: Northwestern University Feinberg School of Medicine /ID# 28169
state: Illinois
city: Chicago
country: United States
facility: John H. Stroger, Jr. Hosp /ID# 40185
state: Illinois
city: Chicago
country: United States
facility: Rush University Medical Center /ID# 47604
state: Illinois
city: Chicago
country: United States
facility: Del Campo, Chicago, IL /ID# 19770
state: Illinois
city: Libertyville
country: United States
facility: Lakeside Dermatology /ID# 247839
state: Illinois
city: Maywood
country: United States
facility: Loyola University Medical Ctr /ID# 23065
state: Illinois
city: Rolling Meadows
country: United States
facility: Arlington Dermatology /ID# 23062
state: Illinois
city: Schaumburg
country: United States
facility: Schaumburg Dermatology, SC /ID# 38294
state: Illinois
city: Wheaton
country: United States
facility: DuPage Medical Group /ID# 18861
state: Illinois
city: Wheaton
country: United States
facility: DuPage Medical Group /ID# 20507
state: Illinois
city: Woodstock
country: United States
facility: Mercy Woodstock Medical Center /ID# 40186
state: Illinois
city: Carmel
country: United States
facility: Shideler Dermatology Group /ID# 69957
state: Indiana
city: Crawfordsville
country: United States
facility: Spencer Dermatology Associates /ID# 71678
state: Indiana
city: Indianapolis
country: United States
facility: Indiana University /ID# 37052
state: Indiana
city: Indianapolis
country: United States
facility: Dawes Fretzin, LLC /ID# 17151
state: Indiana
city: Indianapolis
country: United States
facility: Dawes Fretzin, LLC /ID# 17502
state: Indiana
city: Indianapolis
country: United States
facility: Dermatology Associates of Indiana /ID# 24269
state: Indiana
city: New Albany
country: United States
facility: The Dermatology Center PSC - New Albany /ID# 20501
state: Indiana
city: Plainfield
country: United States
facility: The Indiana Clinical Trials Center /ID# 17153
state: Indiana
city: Hays
country: United States
facility: Great Plains Dermatology, P.A. /ID# 23079
state: Kansas
city: Overland Park
country: United States
facility: Epiphany Dermatology of Kansas LLC /ID# 19764
state: Kansas
city: Topeka
country: United States
facility: Kansas Medical Clinic /ID# 28212
state: Kansas
city: Corbin
country: United States
facility: Knuckles, Corbin, KY /ID# 17101
state: Kentucky
city: Annapolis
country: United States
facility: Anapolis Dermatology Center /ID# 24302
state: Maryland
city: Bethesda
country: United States
facility: Glassman, Bethesda, MD /ID# 17069
state: Maryland
city: Rockville
country: United States
facility: Dermatology and Skin Cancer Specialists, LLC /ID# 65884
state: Maryland
city: White Plains
country: United States
facility: Charles County Dermatology /ID# 18341
state: Maryland
city: Boston
country: United States
facility: Brigham Dermatology Associates /ID# 28207
state: Massachusetts
city: Worcester
country: United States
facility: Worcester Dermatology Assoc. /ID# 37048
state: Massachusetts
city: Ann Arbor
country: United States
facility: David Fivenson, MD, PLC /ID# 20504
state: Michigan
city: Clinton Township
country: United States
facility: Iacobelli, Clinton Twnshp, MI /ID# 38290
state: Michigan
city: Fort Gratiot
country: United States
facility: Hamzavi Dermatology /ID# 25903
state: Michigan
city: Grand Blanc
country: United States
facility: Pinnacle Dermatology - Grand Blanc /ID# 40196
state: Michigan
city: Grand Rapids
country: United States
facility: Stawiski, Grand Rapids, MI /ID# 17124
state: Michigan
city: Norton Shores
country: United States
facility: Lakeshore Dermatology /ID# 24330
state: Michigan
city: Troy
country: United States
facility: Somerset Skin Centre /ID# 17157
state: Michigan
city: Saint Louis
country: United States
facility: St. Louis University /ID# 28150
state: Missouri
city: Saint Louis
country: United States
facility: Metro Hypertension and Kidney /ID# 40184
state: Missouri
city: Saint Louis
country: United States
facility: Dermatology Associates, Inc. /ID# 23075
state: Missouri
city: Wildwood
country: United States
facility: Town Center Dermatology /ID# 28152
state: Missouri
city: Helena
country: United States
facility: Assoc. Derm & Skin Cancer Clin /ID# 24303
state: Montana
city: Omaha
country: United States
facility: Center of Dermatology, P.C. /ID# 23078
state: Nebraska
city: Henderson
country: United States
facility: Academic Dermatology of Nevada /ID# 20513
state: Nevada
city: Las Vegas
country: United States
facility: Linda Woodson Dermatology /ID# 18333
state: Nevada
city: Las Vegas
country: United States
facility: Nathan Adelson Hospice /ID# 18332
state: Nevada
city: Reno
country: United States
facility: Riley, Reno, NV /ID# 36343
state: Nevada
city: Lebanon
country: United States
facility: Dartmouth-Hitchcock Medical Center /ID# 20502
state: New Hampshire
city: Nashua
country: United States
facility: Nashua Dermatology /ID# 18352
state: New Hampshire
city: Belleville
country: United States
facility: Belleville Dermatology Center /ID# 17067
state: New Jersey
city: East Windsor
country: United States
facility: Psoriasis Treatment Center of Central New Jersey /ID# 17148
state: New Jersey
city: Hoboken
country: United States
facility: Fernandez-Obregon, Hoboken, NJ /ID# 23073
state: New Jersey
city: Morristown
country: United States
facility: Fulk, Morristown, TN /ID# 18344
state: New Jersey
city: Somerset
country: United States
facility: UMDNJ R. W. Johnson Med School /ID# 24326
state: New Jersey
city: Summit
country: United States
facility: Derm Consultants of Summit /ID# 24308
state: New Jersey
city: Verona
country: United States
facility: The Dermatology Group, PC /ID# 28158
state: New Jersey
city: Wyckoff
country: United States
facility: Marcus, Wyckoff, NJ /ID# 23074
state: New Jersey
city: Auburn
country: United States
facility: Reflections Dermatology & Psoriasis canter /ID# 19781
state: New York
city: Bayside
country: United States
facility: The Dermatology Center, PSC - Bayside NY /ID# 28170
state: New York
city: Garden City
country: United States
facility: Garden City Dermatology /ID# 42003
state: New York
city: Lawrence
country: United States
facility: Bruckstein, Lawrence, NY /ID# 17063
state: New York
city: New York
country: United States
facility: Scheinfeld, New York, NY /ID# 17136
state: New York
city: New York
country: United States
facility: New York Presbyterian Hospital Weill Cornell Medical Center /ID# 24268
state: New York
city: Oceanside
country: United States
facility: South Nassau Dermatology /ID# 17065
state: New York
city: Rochester
country: United States
facility: The Ctr for Derm at Lifetime /ID# 47603
state: New York
city: Smithtown
country: United States
facility: Dermedx Dermatology, PC /ID# 28163
state: New York
city: Chapel Hill
country: United States
facility: Central Dermatology Center, PA /ID# 17070
state: North Carolina
city: Chapel Hill
country: United States
facility: Dr. Aida Lugo-Somolinos /ID# 24309
state: North Carolina
city: Charlotte
country: United States
facility: Fraser, Charlotte, NC /ID# 19772
state: North Carolina
city: Durham
country: United States
facility: Duke Cancer Center /ID# 24324
state: North Carolina
city: Greensboro
country: United States
facility: Piedmont Dermatology Center /ID# 18326
state: North Carolina
city: New Bern
country: United States
facility: Dermatology Associates of Coastal Carolina /ID# 76116
state: North Carolina
city: Pinehurst
country: United States
facility: Carolina Skin Care /ID# 19773
state: North Carolina
city: Raleigh
country: United States
facility: Andrus and Assoc Dermatology /ID# 20510
state: North Carolina
city: Rocky Mount
country: United States
facility: Boice-Willis Clinic, P.A. /ID# 17125
state: North Carolina
city: Wilmington
country: United States
facility: Crane, Wilmington, NC /ID# 17066
state: North Carolina
city: Wilmington
country: United States
facility: Wilmington Dermatology Center /ID# 69763
state: North Carolina
city: Wilson
country: United States
facility: Polley Clinic of Dermatology /ID# 18334
state: North Carolina
city: Winston-Salem
country: United States
facility: PMG Research of Winston-Salem /ID# 17133
state: North Carolina
city: Akron
country: United States
facility: Hawkins, Akron, Ohio /ID# 28149
state: Ohio
city: Akron
country: United States
facility: Summa Physicians Dermatology /ID# 37051
state: Ohio
city: Athens
country: United States
facility: Oakview Dermatology, LLC /ID# 38298
state: Ohio
city: Austintown
country: United States
facility: Austintown /ID# 76121
state: Ohio
city: Columbus
country: United States
facility: The Ohio State University /ID# 43150
state: Ohio
city: Fairlawn
country: United States
facility: Allied Dermatology and Skin Surgery /ID# 28154
state: Ohio
city: Warren
country: United States
facility: Brodell Medical Inc. /ID# 24304
state: Ohio
city: Oklahoma City
country: United States
facility: Univ Oklahoma HSC /ID# 28145
state: Oklahoma
city: Tulsa
country: United States
facility: Tulsa Dermatology Clinic, Inc. /ID# 71675
state: Oklahoma
city: Portland
country: United States
facility: Oregon Dermatology and Research Center /ID# 24327
state: Oregon
city: Portland
country: United States
facility: Oregon Medical Research Center /ID# 28143
state: Oregon
city: Duncansville
country: United States
facility: Altoona Ctr Clinical Res /ID# 17155
state: Pennsylvania
city: Pittsburgh
country: United States
facility: University of Pittsburgh MC /ID# 17068
state: Pennsylvania
city: Beaufort
country: United States
facility: Mikell, Beaufort, SC /ID# 17143
state: South Carolina
city: Charleston
country: United States
facility: Hampton, Charleston, NC /ID# 18865
state: South Carolina
city: Charleston
country: United States
facility: Coastal Clinical Research Center of the Carolinas /ID# 18353
state: South Carolina
city: Spartanburg
country: United States
facility: Westside Dermatology, LLC /ID# 17541
state: South Carolina
city: Bartlett
country: United States
facility: MidSouth Dermatology /ID# 17128
state: Tennessee
city: Cleveland
country: United States
facility: Skin Cancer & Cosmetic Derm /ID# 65882
state: Tennessee
city: Kingsport
country: United States
facility: Dermatology Associates /ID# 42008
state: Tennessee
city: Arlington
country: United States
facility: Arlington Research Center, Inc /ID# 23063
state: Texas
city: Austin
country: United States
facility: Austin Dermatology Associates /ID# 38296
state: Texas
city: Austin
country: United States
facility: Steiner Ranch Dermatology /ID# 20509
state: Texas
city: Dallas
country: United States
facility: Dermatology Treatment and Research Center /ID# 17545
state: Texas
city: Dallas
country: United States
facility: Aftergut, Dallas, TX /ID# 17041
state: Texas
city: Dallas
country: United States
facility: Texas Dermatology Associates /ID# 28155
state: Texas
city: Dallas
country: United States
facility: Texas Dermatology Associates /ID# 28157
state: Texas
city: Harlingen
country: United States
facility: Schwartz,Harlingen,TX,US /ID# 20725
state: Texas
city: Houston
country: United States
facility: Sonabend, Houston, TX /ID# 17123
state: Texas
city: Houston
country: United States
facility: Heights Dermatology & Aesthetic Center /ID# 28325
state: Texas
city: Houston
country: United States
facility: Memorial Clinical Associates /ID# 17085
state: Texas
city: Houston
country: United States
facility: West Houston Dermatology /ID# 18330
state: Texas
city: Lubbock
country: United States
facility: Lehman Dermatology Clinic /ID# 17082
state: Texas
city: Lubbock
country: United States
facility: Texas Tech University Health Sciences Center - Lubbock /ID# 37050
state: Texas
city: McAllen
country: United States
facility: The Dermatology Inst of S. TX /ID# 38288
state: Texas
city: San Antonio
country: United States
facility: Dermatology Associates of San Antonio /ID# 17150
state: Texas
city: The Woodlands
country: United States
facility: Tucker, The Woodlands, Texas /ID# 38295
state: Texas
city: Spanish Fork
country: United States
facility: Aspen Dermatology, PLLC /ID# 38293
state: Utah
city: Spanish Fork
country: United States
facility: Aspen Dermatology, PLLC /ID# 40183
state: Utah
city: Spanish Fork
country: United States
facility: Aspen Dermatology, PLLC /ID# 40192
state: Utah
city: Ashburn
country: United States
facility: Premier Dermatology /ID# 69958
state: Virginia
city: Tysons Corner
country: United States
facility: Skin and Laser Surgery Center /ID# 40182
state: Virginia
city: Virginia Beach
country: United States
facility: Tidewater Skin Care/Pathology /ID# 71674
state: Virginia
city: Bellingham
country: United States
facility: Dermatology & Laser Center NW /ID# 18324
state: Washington
city: Seattle
country: United States
facility: Dermatology Associates of Seattle /ID# 18328
state: Washington
city: Seattle
country: United States
facility: Dermatology Associates of Seattle /ID# 19802
state: Washington
city: Spokane
country: United States
facility: Premier Clinical Research /ID# 28168
state: Washington
city: Tacoma
country: United States
facility: Komorous, Tacoma, WA /ID# 42007
state: Washington
city: Walla Walla
country: United States
facility: Eastern Washington Dermatology /ID# 17542
state: Washington
city: Bridgeport
country: United States
facility: Saoud, Bridgeport, WV /ID# 17135
state: West Virginia
city: Clarksburg
country: United States
facility: Mountain State Clinical Research /ID# 28146
state: West Virginia
city: Moorefield
country: United States
facility: Hardy County Medical /ID# 28264
state: West Virginia
city: Appleton
country: United States
facility: Dermatology Assoc of WI /ID# 28142
state: Wisconsin
city: Pleasant Prairie
country: United States
facility: Great Lakes Dermatology /ID# 17061
state: Wisconsin
city: Pleasant Prairie
country: United States
facility: Great Lakes Dermatology /ID# 91433
state: Wisconsin
city: Rhinelander
country: United States
facility: Aylesworth, Rhinelander, WI /ID# 18322
state: Wisconsin
city: Sheboygan
country: United States
facility: Shoreline Skin Specialists, SC /ID# 69771
state: Wisconsin
city: St. Pölten
country: Austria
facility: Duplicate_University Hospital St. Polten /ID# 22842
state: Niederoesterreich
city: Linz
country: Austria
facility: Kepler Universitaetsklinikum GmbH /ID# 27922
state: Oberoesterreich
city: Wels
country: Austria
facility: Klinikum Wels-Grieskirchen GmbH /ID# 17543
state: Oberoesterreich
city: Graz
country: Austria
facility: Medizinische Universitaet Graz /ID# 24263
state: Steiermark
city: Vienna
country: Austria
facility: Klinik Landstrasse /ID# 20603
state: Wien
city: Vienna
country: Austria
facility: Dr. Harald Maier /ID# 27921
state: Wien
city: Vienna
country: Austria
facility: Medizinische Universitaet Wien /ID# 18364
state: Wien
city: Vienna
country: Austria
facility: Medizinische Universitaet Wien /ID# 211020
state: Wien
city: Vienna
country: Austria
facility: Klinik Hietzing /ID# 17183
state: Wien
city: Innsbruck
country: Austria
facility: Duplicate_Medizinische Universitat Innsbruck,Universitatsklinik fur Innere Mediz /ID# 22844
city: Salzburg
country: Austria
facility: Landeskrankenhaus Salzburg-Universitätsklinikum der PMU (LKH) /ID# 22843
city: Calgary
country: Canada
facility: Kirk Barber Research, CA /ID# 24204
state: Alberta
city: Edmonton
country: Canada
facility: Stratica Medical /ID# 24266
state: Alberta
city: Surrey
country: Canada
facility: Dr. Chih-ho Hong Medical Inc. /ID# 40199
state: British Columbia
city: Surrey
country: Canada
facility: Enverus Medical Research /ID# 141448
state: British Columbia
city: Vancouver
country: Canada
facility: University of British Columbia - Eye Care Centre, Vancouver General Hospital /ID# 24223
state: British Columbia
city: Winnipeg
country: Canada
facility: Winnipeg Clinic /ID# 37046
state: Manitoba
city: Moncton
country: Canada
facility: Durondel C.P. Inc. /ID# 28136
state: New Brunswick
city: St. John's
country: Canada
facility: Karma Clinical Trials /ID# 37049
state: Newfoundland and Labrador
city: St. John's
country: Canada
facility: Alpha Clinical Research Ctr. /ID# 20581
state: Newfoundland and Labrador
city: St. John's
country: Canada
facility: Nexus Clinical Research /ID# 79198
state: Newfoundland and Labrador
city: St. John's
country: Canada
facility: NewLab Clinical Research Inc. /ID# 18360
state: Newfoundland and Labrador
city: Halifax
country: Canada
facility: Murray, Halifax, CA /ID# 24224
state: Nova Scotia
city: Hamilton
country: Canada
facility: Dermatrials Research /ID# 18363
state: Ontario
city: London
country: Canada
facility: The Guenther Dermatology Research Centre /ID# 79196
state: Ontario
city: Markham
country: Canada
facility: Lynderm Research Inc. /ID# 18362
state: Ontario
city: Newmarket
country: Canada
facility: Entralogix Clinical Research /ID# 79194
state: Ontario
city: Newmarket
country: Canada
facility: Entralogix Clinical Research /ID# 79197
state: Ontario
city: Niagara Falls
country: Canada
facility: Bank on Beauty /ID# 24205
state: Ontario
city: North Bay
country: Canada
facility: North Bay Dermatology Centre /ID# 28138
state: Ontario
city: Peterborough
country: Canada
facility: SKIN Centre for Dermatology /ID# 79195
state: Ontario
city: Toronto
country: Canada
facility: Dr. Jensen Yeung Medicine Professional Corporation /ID# 28141
state: Ontario
city: Waterloo
country: Canada
facility: K. Papp Clinical Research /ID# 28137
state: Ontario
city: Windsor
country: Canada
facility: XLR8 Medical Research /ID# 28140
state: Ontario
city: Drummondville
country: Canada
facility: Dr. Isabelle Delorme Inc. /ID# 79193
state: Quebec
city: Montréal
country: Canada
facility: Innovaderm Research Inc. /ID# 18866
state: Quebec
city: Quebec City
country: Canada
facility: Centre de Dermatologie Maizerets /ID# 20515
state: Quebec
city: Québec
country: Canada
facility: Centre de Recherche dermatologique du Quebec Metropolitain /ID# 18361
state: Quebec
city: Westmount
country: Canada
facility: Dr. Beatrice Wang /ID# 18359
state: Quebec
city: Brno
country: Czechia
facility: Fakultni Nemocnice Brno /ID# 27927
city: Brno
country: Czechia
facility: Fakultni nemocnice u sv. Anny v Brne /ID# 37062
city: Hradec Kralove
country: Czechia
facility: Fakultni nemocnice Hradec Kralove /ID# 40201
city: Olomouc
country: Czechia
facility: Fakultni nemocnice Olomouc /ID# 27930
city: Plzen
country: Czechia
facility: Duplicate_Univ Hosp, Plzen, CZ /ID# 27924
city: Prague 2
country: Czechia
facility: Duplicate_Vseobecna fakultni nemoc Praze /ID# 25907
city: Prague 2
country: Czechia
facility: Duplicate_Vseobecna fakultni nemoc Praze /ID# 27933
city: Praha
country: Czechia
facility: Vseobecna fakultni nemocnice v Praze /ID# 28269
city: Usti Nad Labem
country: Czechia
facility: Krajska zdravotni a.s. Masarykova nemocnice v Usti nad Labem o.z. /ID# 27923
city: Copenhagen NV
country: Denmark
facility: Bispebjerg and Frederiksberg Hospital /ID# 24271
state: Hovedstaden
city: Herlev
country: Denmark
facility: Herlev Hospital /ID# 20602
state: Hovedstaden
city: Aarhus N
country: Denmark
facility: Aarhus University Hospital /ID# 18357
state: Midtjylland
city: Herning
country: Denmark
facility: Hudklinikken /ID# 20729
city: Nice
country: France
facility: Chu de Nice-Hopital L'Archet Ii /Id# 27936
state: Alpes-Maritimes
city: Pierre Benite CEDEX
country: France
facility: HCL - Hopital Lyon Sud /ID# 156129
state: Auvergne-Rhone-Alpes
city: Pierre Benite CEDEX
country: France
facility: HCL - Hopital Lyon Sud /ID# 27940
state: Auvergne-Rhone-Alpes
city: Limoges CEDEX 1
country: France
facility: CHU Limoges - Dupuytren 1 /ID# 25904
state: Franche-Comte
city: Pessac
country: France
facility: CHU Bordeaux - Hopital Haut Leveque /ID# 27934
state: Gironde
city: Lille
country: France
facility: CHRU Lille - Hopital Claude Huriez /ID# 37063
state: Hauts-de-France
city: St. Priest En Jarez
country: France
facility: CHU de SAINT ETIENNE - Hopital Nord /ID# 27942
state: Loire
city: Reims CEDEX
country: France
facility: CHU Reims - Hôpital Robert Debre /ID# 37064
state: Marne
city: Nantes
country: France
facility: CHU de Nantes, Hotel Dieu -HME /ID# 27944
state: Pays-de-la-Loire
city: Poitiers
country: France
facility: Duplicate_CHU de la miletrie /ID# 25906
state: Poitou-Charentes
city: Besancon
country: France
facility: CHRU de Besancon - Site Saint-Jacques /ID# 24202
city: Chambray Les Tours
country: France
facility: CHRU Tours - Hopital Trousseau /ID# 28271
city: Marseille
country: France
facility: AP-HM - Hopital Sainte Marguerite /ID# 28270
city: Nancy
country: France
facility: Hopital Fournier /ID# 27938
city: Paris
country: France
facility: AP-HP - Hopital Saint-Louis /ID# 24203
city: Rouen
country: France
facility: Hôpital Charles-Nicolle /ID# 22845
city: Heidelberg
country: Germany
facility: Universitaetsklinik Heidelberg /ID# 20601
state: Baden-Wuerttemberg
city: Frankfurt am Main
country: Germany
facility: Universitaetsklinikum Frankfurt /ID# 19801
state: Hessen
city: Munster
country: Germany
facility: Universitaetsklinikum Muenster /ID# 37066
state: Niedersachsen
city: Köln
country: Germany
facility: Universitaetsklinikum Koeln /ID# 27950
state: Nordrhein-Westfalen
city: Leipzig
country: Germany
facility: Universitaetsklinikum Leipzig /ID# 20604
state: Sachsen
city: Kiel
country: Germany
facility: Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 22846
state: Schleswig-Holstein
city: Jena
country: Germany
facility: Universitaetsklinikum Jena /ID# 19765
state: Thueringen
city: Bochum
country: Germany
facility: Klinikum Ruhr Univ Bochum /ID# 40200
city: Mainz
country: Germany
facility: Universitaetsmedizin der Johannes Gutenberg-Universitaet Mainz /ID# 37067
city: Athens
country: Greece
facility: General Hospital Andreas Syggros /ID# 22847
state: Attiki
city: Athens
country: Greece
facility: General Hospital Andreas Syggros /ID# 22848
state: Attiki
city: Athens
country: Greece
facility: General Hospital Andreas Syggros /ID# 25905
state: Attiki
city: Piraeus
country: Greece
facility: Tzaneio general hospital of Piraeus /ID# 28237
state: Attiki
city: Crete
country: Greece
facility: Naval Hospital of Crete /ID# 22849
state: Chania
city: Heraklion
country: Greece
facility: University General Hospital of Heraklion PA.G.N.I /ID# 27954
state: Kriti
city: Nea Efkarpia
country: Greece
facility: Duplicate_Papageorgiou General Hospital Thessaloniki /ID# 28232
state: Thessaloniki
city: Athens
country: Greece
facility: Duplicate_Hospital Errikos Ntynan /ID# 28272
city: Giannitsa
country: Greece
facility: General Hospital of Giannitsa /ID# 27951
city: Katerini
country: Greece
facility: General Hospital of Katerini /ID# 27953
city: Thessaloniki
country: Greece
facility: Thessaloniki hospital for skin and venereal diseases- Ippokrateio Thessaloniki /ID# 37068
city: Elm Park
country: Ireland
facility: St Vincent's University Hospital /ID# 43149
state: Dublin
city: Nijmegen
country: Netherlands
facility: Radboud Universitair Medisch Centrum /ID# 24265
state: Gelderland
city: Hoorn Nh
country: Netherlands
facility: Dijklander Ziekenhuis /ID# 18354
state: Noord-Holland
city: Rotterdam
country: Netherlands
facility: Erasmus Medisch Centrum /ID# 24264
state: Zuid-Holland
city: Alkmaar
country: Netherlands
facility: Centrum Oosterwal /ID# 18349
city: Almelo
country: Netherlands
facility: ZiekenhuisGroep Twente /ID# 18355
city: Amsterdam
country: Netherlands
facility: Academisch Medisch Centrum /ID# 22850
city: Breda
country: Netherlands
facility: Amphia Ziekenhuis /ID# 20461
city: Goes
country: Netherlands
facility: Duplicate_Duplicate_Oosterschelde Ziekenhuis /ID# 20462
city: Haarlem
country: Netherlands
facility: Spaarne Gasthuis /ID# 22851
city: Voorburg
country: Netherlands
facility: Diaconessenhuis Voorburg /ID# 18868
city: San Juan
country: Puerto Rico
facility: Dr. Reinaldo Rosario Med Offic /ID# 24328
city: Badalona
country: Spain
facility: Hospital Universitario Germans Trias i Pujol /ID# 17152
state: Barcelona
city: Hospitalet de Llobregat
country: Spain
facility: Hospital Duran i Reynals /ID# 18348
state: Barcelona
city: Alcorcon
country: Spain
facility: Hospital Universitario Fundacion Alcorcon /ID# 20723
state: Madrid
city: Alicante
country: Spain
facility: Hospital General Universitario de Alicante Doctor Balmis /ID# 20730
city: Barcelona
country: Spain
facility: Hospital Universitari Sagrat Cor - Grupo Quiron Salud /ID# 19767
city: Barcelona
country: Spain
facility: Hospital Clinic de Barcelona /ID# 19803
city: Madrid
country: Spain
facility: Hospital Universitario de la Princesa /ID# 18867
city: Madrid
country: Spain
facility: Hospital Universitario 12 de Octubre /ID# 18365
city: Zaragoza
country: Spain
facility: Hospital Clinico Universitario Lozano Blesa /ID# 19763
city: Uppsala
country: Sweden
facility: Uppsala University Hospital /ID# 38283
city: London
country: United Kingdom
facility: The Royal Free London NHS Foundation Trust /ID# 40205
state: London, City Of
city: London
country: United Kingdom
facility: Guys and St Thomas NHS Foundation Trust /ID# 28273
state: London, City Of
city: Glasgow
country: United Kingdom
facility: NHS Greater Glasgow and Clyde /ID# 27956
state: Scotland
city: Cardiff
country: United Kingdom
facility: Cardiff & Vale University Health Board /ID# 40204
state: Wales
city: Aberdeen
country: United Kingdom
facility: NHS Grampian /ID# 37069
city: Leeds
country: United Kingdom
facility: Leeds Teaching Hospitals NHS Trust /ID# 40202
city: Manchester
country: United Kingdom
facility: Northern Care Alliance NHS Group /ID# 40203
Study officials:
affiliation: AbbVie
name: ABBVIE INC.
role: STUDY_DIRECTOR
References:
citation: Lynde CW, Alam MS, Ohson K, Gagne-Henley A, Avadisian M, Vender RB. Enhanced Effectiveness of Adalimumab Compared to Topical/Traditional Systemic Agents in the Treatment of Moderate to Severe Plaque Psoriasis: Results from a Canadian Observational Epidemiologic Study (COMPLETE-PS). Dermatol Ther (Heidelb). 2022 Apr;12(4):921-931. doi: 10.1007/s13555-022-00703-3. Epub 2022 Mar 14.
citation: Menter A, Thaci D, Wu JJ, Abramovits W, Kerdel F, Arikan D, Guo D, Ganguli A, Bereswill M, Camez A, Valdecantos WC. Long-Term Safety and Effectiveness of Adalimumab for Moderate to Severe Psoriasis: Results from 7-Year Interim Analysis of the ESPRIT Registry. Dermatol Ther (Heidelb). 2017 Sep;7(3):365-381. doi: 10.1007/s13555-017-0198-x. Epub 2017 Aug 16.