Clinical trial NCT01547975: Retrospective Analysis of Surgical Outcomes After Corneal Transplantation
Official title: Retrospective Analysis of Surgical Outcomes After Corneal Transplantation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Corneal Transplantation
Keywords: surgical outcomes after corneal transplantation
Retrospective analysis
corneal transplantation
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2012-03-08
Enrollment: 1000
Sex: ALL
Maximum age (years): 90
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CROSSOVER
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The patients who received corneal transplantation within full chart records.

Brief summary: Currently, no demographic and surgical results comparing different donor cornea sources were available in Taiwan. National Taiwan University Hospital (NTUH), as one of the largest tertiary medical centers in northern Taiwan, is now in charge of a big part of intense care for patients receiving corneal transplantation. With detailed medical record done of these patients during care in the ward and out-patient clinic, the investigators are competence for this meaningful program.

Detailed description: An insufficient donor supply is a worldwide problem in organ transplantation. Even with corneal transplantations, the most widely performed transplantation, shortages and imbalances in donor supply is a global concern. In National Taiwan University Hospital (NTUH), the investigators performed over one hundred of corneal transplantations every year and the majority of donor corneas were from the eye bank in United States. Previous literature showed satisfactory results in corneal transplantation using foreign donor corneas compared with domestic corneas. However longer preservation time had associated with a statistically significant increased risk of persistence of the postoperative epithelial defect. On the other hand, longer storage times may allow better outcomes in high-risk grafts because of the depletion of donor T cells from the donor cornea into the storage media.

Currently, no demographic and surgical results comparing different donor cornea sources were available in Taiwan. NTUH, as one of the largest tertiary medical centers in northern Taiwan, is now in charge of a big part of intense care for patients receiving corneal transplantation. With detailed medical record done of these patients during care in the ward and out-patient clinic, the investigators are competence for this meaningful program.

Eligibility criteria: Inclusion Criteria:

* The patients who received corneal transplantation within full chart records

Exclusion Criteria:

* The patients have cognitive Impairment.
* No detail or unclear ophthalmologic record.
* Patients or their legal representative have no willing to accept this tracing study.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital, department of Ophthalmology
Study officials:
affiliation: NTUH
name: Wei-Li Chen, MD,PhD
role: STUDY_CHAIR
References: