louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03881033: Determination of Optimal Mask Ventilation Mode in Pediatrics Using Real-time Ultrasonography
Official title: Determination of Optimal Mask Ventilation Mode in Pediatrics Using Real-time Ultrasonography
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Ventilator Lung
Ultrasound
Lead sponsor: Ajou University School of Medicine
Sponsor class: OTHER
First posted: 2019-03-19
Enrollment: 70
Sex: ALL
Minimum age (years): 1
Maximum age (years): 5
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The peak inspiratory pressure during face mask ventilation for general anesthesia is closely correlated with gastric insufflation. High pressure increases the amount of air in stomach and low pressure could decrease the tidal volume, therefore ideal pressure means the pressure guarantee adequate ventilation with minimal gastric insufflation.

The aim of this study is finding the proper pressure and mode of face mask ventilation in pediatric patients.


Eligibility criteria: Inclusion Criteria:

* The ASA class I,II and 1-5 years pediatric patients need general anesthesia

Exclusion Criteria:

* Oropharyngeal or facial pathology accompanied
* Obese (BMI \> 30 kg/m2)
* GI tract obstruction

Primary outcomes:
measure: The degree of atelectasis
timeFrame: 1min after ventilator-on
Secondary outcomes:
measure: The incidence of gastric insufflation
timeFrame: During face mask ventilation
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01368133: The Observational Study of Growth Hormone-secreting Pituitary Tumors
Official title: The Observational Study of the Structures and Functions of Multiple Organs in Patients With Growth Hormone-secreting Tumors
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Acromegaly
Pituitary Tumor
Keywords: acromegaly
pituitary tumor
Lead sponsor: Huashan Hospital
Sponsor class: OTHER
Collaborators: name: National Natural Science Foundation of China
First posted: 2011-06-07
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The acromegaly patients at Huashan Hospital will be recruited anf followed up prior to surgery and one month, 3 months, 6 months and 12 months after surgery.

Brief summary: The major purpose of this study is to evaluate the changes of multiple organs in patients with growth hormone-secreting pituitary tumors before and after surgery. Plasma, DNA samples and pituitary tumor tissues will be kept for further analysis.

Detailed description: Multiple organs or systems will be affected by excessive growth hormones in patients with acromegaly. The major purpose of this study is to evaluate the changes before and after the pituitary surgery.

Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of acromegaly
* \> 18 years old

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Huashan Hospital
Study officials:
affiliation: Huashan Hospital
name: Yao Zhao, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01671033: Treatment of Panic Disorder Via Internet With a Wireless Temperature Biofeedback Ring
Official title: Muscle Relaxation With Biofeedback Via Internet for Panic disorder-a Randomized Pilot Study
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Panic Disorder
Keywords: Panic disorder
cognitive behavior therapy
Internet
Lead sponsor: Chimei Medical Center
Sponsor class: OTHER
Collaborators: name: National Cheng Kung University
First posted: 2012-08-23
Enrollment: 9
Sex: ALL
Minimum age (years): 20
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: From the scarce literature it showed that computer/internet-aided cognitive behavior therapy (CBT) was superior to waitlist and placebo assignment across outcome measures, and the effects of computer/internet-aided CBT were equal to therapist-delivered treatment across anxiety disorders. The aim of this study is to evidence the effectiveness of internet-based relaxation with biofeedback treatment for panic disorder.

Detailed description: All participants had access to a computer with an internet connection and received the treatment via internet.

Eligibility criteria: Inclusion Criteria:

1. The participant must fulfill DSM-IV criteria for panic disorder.
2. The participant must be between 20 and 60 years of age.
3. The participant must have the Panic Disorder Severity Scale(PDSS) score ≧8.
4. If the participant is taking prescribed drugs for panic disorder, a) the dosage have to be constant for 6 weeks before starting treatment, and b) the participant have to agree to keep the dosage constant for 2 months after starting treatment.
5. If the participant was already in therapy, the contact must have lasted at least 3 months and not be based on cognitive behavior therapy.
6. All participants have access to a computer with an Internet connection.

Exclusion Criteria:

1. The participant suffers from any other psychiatric disorder in immediate need of treatment.
2. The participant fulfills DSM-IV criteria for major depression.
3. The participant has epilepsy, kidney problems, strokes, organic brain syndrome, emphysema, heart disorders, or chronic hypertension.
4. The participant has alcoholism or substance dependence.

Primary outcomes:
measure: Score Change of The Panic Disorder Severity Scale(PDSS)
timeFrame: Baseline / Week 4/ Week 8/ Week12/ Week 16
Secondary outcomes:
measure: Score Change of relaxation-rating
timeFrame: Baseline / Week 4/ Week 8/ Week 12/ Week 16
Other outcomes:
Locations:
city: Tainan
country: Taiwan
facility: Chimei Medical Center
Study officials:
affiliation: Chimei Medical Center
name: Fong-Lin Jang, M.D.
role: STUDY_DIRECTOR
References:
Clinical trial NCT01262833: Pudendal Assessment in Erectile Dysfunction
Official title: A Cohort Study of the Functional Significance of Internal Pudendal Artery Stenoses in Patients With Erectile Dysfunction
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Erectile Dysfunction
Lead sponsor: University of Pennsylvania
Sponsor class: OTHER
First posted: 2010-12-17
Enrollment: 10
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: sexually active men, scheduled for cardiac catheterization or peripheral artery catheterization, who have at least one risk factor for ED

Brief summary: The study will address the role of internal pudendal artery disease in erectile dysfunction (ED), and whether it might eventually be amenable to intervention with stenting. There is currently a small trial investigating the potential benefit of stenting for erectile dysfunction, but the relationship between pelvic arterial stenoses and erectile dysfunction is not yet proven. The investigators intend to perform angiography on patients both with and without erectile dysfunction, to see whether internal pudendal artery disease is more common in the population with erectile dysfunction. In addition to angiography, stenoses will be examined using fractional flow reserve. The degree of internal pudendal artery disease will then be correlated with the degree of erectile dysfunction using a validated questionnaire, the International Index of Erectile Function (IIEF). Patients will then complete IIEF questionnaires for 5 years to assess the relationship between internal pudendal artery disease and progression of erectile dysfunction.


Eligibility criteria: Inclusion Criteria:

* As above, men with one risk factor for ED such as age\>55, diabetes, hyperlipidemia, smoking, hypertension, coronary disease or peripheral arterial disease

Exclusion Criteria:

* Patients with ED from a non-arterial cause, including hormonal, neurological, or trauma-related (as determined by past medical history routinely performed prior to catheterization)
* Patients requiring urgent catheterization (e.g. acute coronary syndrome or cardiogenic shock)
* Patients with a creatinine \>1.5 mg/dL and those deemed at increased renal risk (such as from receiving \>200 mL of dye during the primary procedure, post renal transplant or single kidney), as the additional contrast dye required for angiography would pose an undue risk of progressive kidney disease
* Patients with other illnesses that reduce their life expectancy to less than one year

Primary outcomes:
measure: Pudendal Assessment in Erectile Dysfunction
timeFrame: Up to Five years
Secondary outcomes:
measure: Pudendal Assessment in Erectile Dysfunction
timeFrame: up to five years
Other outcomes:
Locations:
city: Philadelphia
country: United States
facility: University of Pennsylvania
state: Pennsylvania
Study officials:
affiliation: University of Pennsylvania
name: Howard Herrmann, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00965133: Endurance Training in Young Persons With Cerebral Palsy; Evaluation of Training Method and Effect
Official title: Enthusiasm - Sweat - Satisfaction! In Youngster With CP
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cerebral Palsy
Lead sponsor: Reidun Lauglo
Sponsor class: OTHER
Collaborators: name: Rosenborgklinikken
name: Norwegian University of Science and Technology
name: St. Olavs Hospital
First posted: 2009-08-25
Enrollment: 24
Sex: ALL
Minimum age (years): 10
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The hypotheses of the study are that children / youth with CP will by possibly use of technical aids be able to perform high intensity endurance training by walking / running on a treadmill, and that this training will improve their health by increased aerobic capacity and quality of life.


Eligibility criteria: Inclusion Criteria:

* Person with CP, GMFCS-level I-IV, age 10-17 years
* Living in Mid-Norway
* Wants to increase his / her level of physical activity

Exclusion Criteria:

* Completes less than 75% of the total number of training sessions
* Not able to complete the testing and training procedures due to sickness, injury or other physical and psychological conditions

Primary outcomes:
measure: Aerobic capacity
timeFrame: Sept. 2009 - april 2010
Secondary outcomes:
measure: Quality of life
timeFrame: Sept. 2009 - April 2010
Other outcomes:
Locations:
city: Trondheim
country: Norway
facility: Rosenborgklinikken
Study officials:
References:
citation: Lauglo R, Vik T, Lamvik T, Stensvold D, Finbraten AK, Moholdt T. High-intensity interval training to improve fitness in children with cerebral palsy. BMJ Open Sport Exerc Med. 2016 May 9;2(1):e000111. doi: 10.1136/bmjsem-2016-000111. eCollection 2016.
Clinical trial NCT03389633: Does Cardiac Rehabilitation Reduce the Risk of Recurrence of Atrial Fibrillation Following the First Catheter Ablation?
Official title: Does Cardiac Rehabilitation Reduce the Risk of Recurrence of Atrial Fibrillation Following the First Catheter Ablation?
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Atrial Fibrillation
Lead sponsor: Hasselt University
Sponsor class: OTHER
First posted: 2018-01-03
Enrollment: 462
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Many risk factors contribute to the onset of atrial fibrillation. This study is specifically concerned with the effect of addressing these risk factors by cardiac rehabilitation on the risk of recurrence of atrial fibrillation following catheter ablation. A non-randomized, retrospective study was performed on patients treated with a catheter ablation for atrial fibrillation. The intervention group consisted of patients who chose to participate in the cardiac rehabilitation program. The control group only received standard care. The primary objective was to examine whether cardiac rehabilitation following the first ablation for atrial fibrillation resulted in a reduction of the time to or the risk of recurrence of atrial fibrillation or the need for a second ablation within 1 year after the first ablation. A Kaplan-Meier analysis was used to examine the primary objective. The secondary objectives of this study were to examine whether cardiac rehabilitation following the first ablation for atrial fibrillation had an effect on the evolution of the patients' BMI (a Mann-Whitney U test), the number of recurrences of atrial fibrillation (a Poisson regression) and the proportion of patients who need to continue treatment with antiarrhythmics 3 months following the first ablation (a chi-square test).

Detailed description: The intervention group follows a 3 months rehab program consisting of training, education, coaching and medical follow-up. The control group are patients that chose not to follow this program. This is a retrospective non randomized trial

Eligibility criteria: Inclusion Criteria:

* an ablation for AF (Atrial fibrillation)

Exclusion Criteria:

* a complicated ablation
* a prosthetic heart valve
* a severe valvulopathy,
* hyperthyroidism at the time of the ablation,
* pregnancy and breastfeeding,
* intensive sport (more than 1 hour a day),
* a myocardial infarction or a thromboembolic event within 3 months after the ablation,
* a pacemaker
* end-stage renal disease.

Primary outcomes:
measure: Number of recurrences of atrial fibrillation or need for new ablation
timeFrame: from 3 months after discharge until 1 year
Secondary outcomes:
measure: The proportion of patients who needed to continue treatment with antiarrhythmics
timeFrame: month 3 until one year
Other outcomes:
Locations:
Study officials:
affiliation: Jessa Hospital
name: Paul Dendale, prof. dr.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06757933: Comparison Of Spencer Technique And Isotonic Exercise In Patients With Adhesive Capsulitis
Official title: Comparison Of Spencer Technique And Isotonic Exercise In Patients With Adhesive Capsulitis
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Adhesive Capsulitis, Shoulder
Lead sponsor: Superior University
Sponsor class: OTHER
First posted: 2025-01-03
Enrollment: 64
Sex: ALL
Minimum age (years): 30
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This study examines the efficacy of two forms of therapy for Adhesive Capsulitis, a condition characterized by stiffness, pain, and limited mobility in the shoulder joint. It is also commonly known as "Frozen Shoulder".

Detailed description: Patients between the ages of 30 and 55 were randomly assigned to one of two groups for the trial held at the Saleem Free Hospital Okara and Dar-ul-Shifa Hospital. Group 2 engaged in isotonic exercises that emphasized concentric and eccentric motions of forward flexion and extension, whereas Group 1 was given the Spencer approach, which involved seven different movements. A goniometer and the Numeric Pain Rating Scale were used to measure the range of motion and pain. SPSS 20 was used to analyze the data and assess how well the treatments worked. The findings provided light on how well manual therapy and exercise compare in terms of reducing pain and increasing shoulder movement in people with adhesive capsulitis.

Eligibility criteria: Inclusion Criteria

* Both genders aged 30-55 years
* Unilateral Adhesive Capsulitis
* Pain lasting for more than one month
* Capsular pattern of motion restriction
* Diabetic patients were included.

Exclusion Criteria

* Participants with rotator cuff tear
* Rheumatoid and gouty arthritis
* Tumors of the shoulder region
* Peripheral nerve injuries
* Shoulder girdle fracture and dislocation
* History of shoulder surgery were excluded.

Primary outcomes:
measure: The Numeric Pain Rating Scale
timeFrame: 12 Months
measure: goniometer
timeFrame: 12 Months
Secondary outcomes:
Other outcomes:
Locations:
city: Okāra
country: Pakistan
facility: Dr. Saleem Memorial Free Hospital Address: College road, Depalpur Rd, adjacent baldia hall, Okara
state: Punjab
Study officials:
References:
Clinical trial NCT05645133: QPlus Pediatric Reference Interval
Official title: Evaluation of a Pediatric Reference Interval Using QPLUS System
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Pediatric ALL
Healthy
Keywords: QPlus
Quantra
Pediatric
Reference Range
Lead sponsor: HemoSonics LLC
Sponsor class: INDUSTRY
First posted: 2022-12-09
Enrollment: 93
Sex: ALL
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Pediatric patients with normal coagulation function who have been scheduled to undergo a procedure and blood sampling access has been established. All genders, racial and ethnic profiles will be described.

Brief summary: Evaluation of coagulation results reported by the Qplus Quantra System to determine pediatric reference range intervals.

Detailed description: Single center observational study of the pediatric patient population (\< 18yrs) with normal coagulation function to determine the reference range interval for the clotting parameters reported by the Quantra QPlus system.

Eligibility criteria: Inclusion Criteria:

* \<18yrs
* Scheduled for procedure requiring anesthesia
* Access to blood sampling
* Consented

Exclusion Criteria:

* \>18yrs of age
* pre-term babies
* patients with know hematological disorders
* Difficult to obtain blood sampling
* Has received a blood product transfusion within the last 24hrs.
* Legal guardian unwilling to consent

Primary outcomes:
measure: Reference range interval for measurement of clot time (CT) parameter
timeFrame: Baseline, after access placement before any procedures
measure: Reference range interval for measurement of clot time (CTH) parameter
timeFrame: Baseline, after access placement before any procedures
measure: Reference range interval for measurement of clot stiffness (CS) parameter
timeFrame: Baseline, after access placement before any procedures
measure: Reference range interval for measurement of Fibrinogen Contribution to clot stiffness (FCS) parameter
timeFrame: Baseline, after access placement before any procedures
measure: Reference range interval for measurement of Platelet Contribution to clot stiffness (PCS) parameter
timeFrame: Baseline, after access placement before any procedures
Secondary outcomes:
Other outcomes:
Locations:
city: Miami
country: United States
facility: Nicklaus Childrens Hospital
state: Florida
Study officials:
affiliation: Nicklaus Childrens
name: Christopher Tirotta, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02792933: Air Versus Saline Solution for the Localization of the Epidural Space in Labour Analgesia
Official title: Localization of the Epidural Space Using the Loss of Resistance Technique for Labour Analgesia: A Randomized Controlled Trial Comparing Air Versus Saline Solution
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Effects of Anesthesia Spinal and Epidural in Pregnancy
Lead sponsor: Instituto de Investigación Hospital Universitario La Paz
Sponsor class: OTHER
First posted: 2016-06-08
Enrollment: 400
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: Epidural space localization using loss of resistance technique with air (ALOR) is controversial in obstetric analgesia due to a minor efficacy and risk of complications, compared with loss of resistance technique with saline (SLOR). This randomized prospective study will compare the efficacy and incidence of most common complications of both techniques in obstetric analgesia.

Detailed description: A local ethics committee has approved the study. A statistical power calculation was performed and 177 patients per group will be necessary to confirm a 20% difference of efficacy of the block at 30 minutes (α=0,05; β=0,1). Epidural catheter will be inserted and a standardized analgesic protocol will initiate. The efficacy of the block will be assessed after 30 minutes and at delivery. The apparition of adverse effects during puncture and labour will be annotated. The need for repuncture of the block and the repercussion of the technique on the delivery and the fetus will be recorded as well. At 24 hours, investigators will assess the incidence of pain at the site of puncture (PSP) and the level of maternal satisfaction on a 0 to10 numeric scale.

Eligibility criteria: Inclusion criteria:

* Parturients asking for epidural analgesia during labour .
* Age between 18 and 45 years.
* Spontaneous or induced.
* Cervical dilatation inferior to 6 cm.
* Written informed consent.

Exclusion criteria:

* Infection in the puncture site.
* Refusal of the patient.
* Coagulopathy.
* Severe hypovolaemia.
* Intracranial hypertension.
* Severe aortic or mitral stenosis.
* Systemic infection.
* Non collaborating patient.
* Incapacity of communicating or lack of comprehension of the study by the parturient
* Prior neurological symptoms or demyelinising lesions.
* Valvular stenosis.
* Severe spinal deviation.
* Patient previously operated of spinal surgery in the site of puncture.

Primary outcomes:
measure: Analgesia obtained 30 minutes after the puncture of the epidural block (variation of pain score)
timeFrame: 30 min
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Antibas PL, do Nascimento Junior P, Braz LG, Vitor Pereira Doles J, Modolo NS, El Dib R. Air versus saline in the loss of resistance technique for identification of the epidural space. Cochrane Database Syst Rev. 2014 Jul 18;2014(7):CD008938. doi: 10.1002/14651858.CD008938.pub2.