louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT07007897: Observational Study - TA- 2025-1
Official title: Toric Alignment Observational Study 2025-1
Study type: OBSERVATIONAL
Overall status: ENROLLING_BY_INVITATION
Conditions: Astigmatism
Lead sponsor: Haag-Streit AG
Sponsor class: INDUSTRY
First posted: 2025-06-06
Enrollment: 100
Sex: ALL
Minimum age (years): 21
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Any individual over the age of 21 seeking elective cataract surgery at the study sites.

Brief summary: This multi-centric, prospective observational study collects biometric datasets as well as associated video recordings of the surgical procedure.


Eligibility criteria: Inclusion Criteria:

* diagnosed with cataracts (any grade),
* Seeking cataract treatment,
* willing to provide informed consent.

Exclusion Criteria:

* Active ocular infections or trauma.
* Poor fixation ability (e.g., severe nystagmus).
* Prior intraocular surgery.
* Seeking toric IOL implantation requiring ink marking.

Primary outcomes:
measure: Biometric data
timeFrame: one-time measurement before surgery
measure: Video recording
timeFrame: during the surgical procedure
Secondary outcomes:
measure: Software algorith
timeFrame: up to 6 months
Other outcomes:
Locations:
city: Mesa
country: United States
facility: East Valley Ophthalmology
state: Arizona
city: Eugene
country: United States
facility: Pacific Clear Vision Institute
state: Oregon
Study officials:
affiliation: Haag-Streit
name: Jan Rübel, PhD
role: STUDY_CHAIR
affiliation: Haag-Streit
name: Julian V Kool van Langenberghe, ing
role: STUDY_DIRECTOR
References:
Clinical trial NCT03834597: GlideScope® Versus Macintosh Laryngoscope for Post-thyroidectomy Assessment of Vocal Cord Mobility
Official title: GlideScope® Versus Macintosh Laryngoscope for Post-thyroidectomy Assessment of Vocal Cord Mobility
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Complication, Postoperative
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2019-02-08
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients undergoing elective thyroid surgery

Brief summary: Vocal cord dysfunction is a serious post-thyroidectomy complication. This can lead to various postoperative clinical consequences as hoarseness of voice, aspiration or stridor . It is also one of the common reasons for post-thyroidectomy malpractice claims.

This study will compare GlideScope® with Macintosh laryngoscope regarding accuracy of assessment of post-thyroidectomy vocal cord mobility.


Eligibility criteria: Inclusion Criteria:

* American Society of Anesthesiologists (ASA) physical status I and II,
* Elective thyroid surgery with
* Normal thyroid profile

Exclusion Criteria:

* History of previous thyroid surgery,
* Preoperative vocal cord dysfunction
* Predicted difficult airway

Primary outcomes:
measure: Vocal cord dysfunction
timeFrame: Intraoperative
Secondary outcomes:
measure: Incidence of traumatic complications
timeFrame: First 24 hours postoperatively
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Ain Shams University hospitals
Study officials:
References:
Clinical trial NCT01450397: MRI Results in Dupuytren's Contracture Before and After Injection With Xiaflex
Official title: MRI Results in Dupuytren's Contracture Before and After Injection With Xiaflex
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Dupuytren's Disease
Keywords: Dupuytren's Contracture
Lead sponsor: Hospital for Special Surgery, New York
Sponsor class: OTHER
Collaborators: name: Auxilium Pharmaceuticals, Inc.
First posted: 2011-10-12
Enrollment: 5
Sex: ALL
Minimum age (years): 35
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine the effects of XIAFLEX on your finger through MRI.

Detailed description: Collagenase injections for the treatment of Dupuytren's Contracture is a newly approved protocol which has shown early efficacy. There are very few studies which examine the MRI appearance of Dupuytren's disease. There are no studies that evaluate the condition of the cord after collagenase injection.

Eligibility criteria: Inclusion Criteria:

* Subject has a diagnosis of Dupuytren's Disease affecting only the metacarpophalangeal joint of the 4th or 5th finger.
* Subject has only one finger affected by the disease.
* Patients will be 35 years of age of older.
* Patients will be able to read, speak, and understand English or have available adequate translation assistance and be able to provide voluntary written consent to participate.

Exclusion Criteria:

* Female patients who are nursing or pregnant, or plan to become pregnant during the treatment phase.
* Patient has a chronic muscular, neurological or neuromuscular disorder that affects the hands.
* Patient has known allergy to collagenase or any other excipient of Xiaflex.
* Patient has received any collagenase treatments before the first dose of Xiaflex.
* Patient with abnormal coagulation, including patients who have received anticoagulant medications other than low-dose aspirin within 7 days of the injection.

Primary outcomes:
measure: The Measured Change in Volume of the Cord by MRI Before and After XIAFLEX Injection and Manual Manipulation.
timeFrame: Baseline and 30 days
Secondary outcomes:
Other outcomes:
Locations:
city: New York
country: United States
facility: Hosptial for Special Surgery
state: New York
Study officials:
affiliation: Hospital for Special Surgery, New York
name: Scott W Wolfe, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01121497: The Effect of Physostigmine on Cognitive Functioning in the Immediate Period After Sedation for Colonoscopy
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Cognitive Dysfunction
Keywords: Sedation
Cognitive decline
Physostigmine
Colonoscopy
Lead sponsor: Rabin Medical Center
Sponsor class: OTHER
First posted: 2010-05-12
Enrollment: 160
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to determine whether the administration of physostigmine in combination with sedation for colonoscopy can minimize the cognitive decline at the time of hospital discharge

Detailed description: Physostigmine, a tertiary cholinesterase inhibitor, which prevents the breakdown of ACh by inhibiting the enzyme acetylcholinesterase (AChE), crosses the blood-brain barrier (BBB), and elevates brain ACh levels. Physostigmine has been shown to improve attention, and performance in working memory. It has also been shown to produce analgesia following systemic or central administration.

Patients undergoing colonoscopy under sedation of propofol and fentanyl show cognitive decline in the immediate period following the procedure. In this study, half the patients will receive physostigmine in combination with the sedation, and their cognitive functioning at the time of hospital discharge will be assessed by standard neuropsychological tests, and compared to that of patients without physostigmine.

Eligibility criteria: Inclusion Criteria:

* Over18 years old
* ASA I-III
* Fluency in Hebrew, Russian, or Arabic
* Absence of serious hearing or vision impairment

Exclusion Criteria:

* History of head trauma, neurological diseases, alcoholism, drug abuse, consumption of psychotropic drugs or antidepressants
* Heart failure (NYHA \> 3)
* Liver failure
* Respiratory problems (asthma, etc.)

Primary outcomes:
measure: Cognitive functioning assessed by standard neuropsychological tests
timeFrame: At time of hospital discharge following colonoscopy procedure
Secondary outcomes:
Other outcomes:
Locations:
city: Petah Tiqva
country: Israel
facility: Hasharon Hospital, Rabin Medical Center
Study officials:
affiliation: Hasharon Hospital, Rabin Medical Center
name: Bezion Beilin, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02869997: Evaluation of the Prognostic Value of the Suppression Ratio Evaluated by BIS Among Patients Admitted to the ICU for Cardiac Arrest
Official title: Evaluation of the Prognostic Value of the Suppression Ratio Evaluated by BIS Among Patients Admitted to the ICU for Cardiac Arrest
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Cardiac Arrest
Lead sponsor: Centre Hospitalier Universitaire de Besancon
Sponsor class: OTHER
First posted: 2016-08-17
Enrollment: 102
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The aim of this study is to evaluate the prognostic value of the suppression ratio monitored by Bispectral Index for prediction of neurologic outcome after cardiac arrest. All patient admitted to our intensive care unit after a cardiac arrest are included. The results of the suppression ratio will be collected in the 6 first hours of admission. We will evaluate the link between suppression ratio and cerebral performance category score collected at three months.


Eligibility criteria: Inclusion Criteria:

* Adult
* Cardiac arrest admitted to the ICU

Exclusion Criteria:

- Pregnancy

Primary outcomes:
measure: Cerebral Performance Category score
timeFrame: 3 months
Secondary outcomes:
Other outcomes:
Locations:
city: Besançon
country: France
facility: CHRU Besançon
Study officials:
affiliation: CHRU Besançon
name: François Belon, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05637697: Angelman Syndrome Video Assessment (ASVA) Source Material Study
Official title: Angelman Syndrome Video Assessment (ASVA) Source Material Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Angelman Syndrome
Keywords: Angelman Syndrome
Lead sponsor: The Emmes Company, LLC
Sponsor class: INDUSTRY
Collaborators: name: Ionis Pharmaceuticals, Inc.
name: Boston Children's Hospital
First posted: 2022-12-05
Enrollment: 73
Sex: ALL
Minimum age (years): 1
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 40 participants with Angelman Syndrome (AS) and their caregivers (AS-caregiver dyads) and up to 15 neurotypically (NT) developing children and their caregivers (NT-caregiver dyads) for a total of up to 55 participant-caregiver dyads. AS-caregiver dyads will be recruited for this study through referrals from collaborators and advocacy groups as well as through direct marketing via social media.

Brief summary: This is a longitudinal, observational, nonrandomized, fully remote study enrolling approximately 55 participant-caregiver dyads. The study includes no treatments or interventions, and participants will not be asked to change their current treatments. The objective of this study is to gather sufficient source material videos to develop a scoring system for ASVA and to perform preliminary validation of that scoring system.


Eligibility criteria: * Caregiver reports that the individual with AS has a laboratory-confirmed diagnosis of Angelman syndrome
* Individual with AS is at least 1 year old
* Caregiver is willing and able to provide informed consent for themselves and oversee study participation
* Caregiver or legal guardian is willing to provide informed consent on behalf of the individual with AS
* Caregiver is comfortable reading and speaking in English
* Caregiver has access to a smartphone or tablet that is compatible with the study app OR caregiver has internet access and is willing to use a wi-fi only device to record and upload videos

NT-Caregiver dyads will be eligible for inclusion if the:

* Neurotypical individual is between 1 and 8 years of age
* Caregiver is willing and able to provide informed consent and oversee study participation and NT individual is willing and able to provide assent, as applicable
* Caregiver is comfortable reading and speaking in English
* Caregiver has access to a smartphone or tablet that is compatible with the study app OR caregiver has internet access and is willing to use a wi-fi only device to record and upload videos Participant-Caregiver dyads will be excluded from the study only if they do not meet the inclusion criteria above.

Primary outcomes:
measure: Source material collection, Baseline
timeFrame: Baseline
measure: Source material collection, Week 12
timeFrame: Week 12
Secondary outcomes:
Other outcomes:
Locations:
city: Kingston
country: United States
facility: Casimir
state: Massachusetts
Study officials:
affiliation: Casimir
name: Mindy Leffler
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04192097: Impact of a Curriculum About Professionalism on Stress Response During a Critical Situation
Official title: Impact of a Curriculum About Professionalism on Stress Response During a Critical Situation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Professional Burnout
Professional Stress
Anesthesia
Medical Education
High Fidelity Simulation
Anxiety State
Keywords: Cardiopulmonary arrest
Family patient meeting
Lead sponsor: University Grenoble Alps
Sponsor class: OTHER
First posted: 2019-12-10
Enrollment: 20
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to evaluate the impact of a curriculum about professionalism on stress response during a critical situation in anesthesiology residents. Residents in anesthesiology will complete a training program on professionalism during their first postgraduate year. They will go through a standardized simulated scenario where they have to manage an intra-hospital cardiorespiratory arrest and then meet the patient's family. Stress response will be assessed and compared to a control group that did not receive the training program.


Eligibility criteria: Inclusion Criteria:

* Residents in anesthesiology (Postgraduate year 1)
* Voluntary

Exclusion Criteria:

* /

Primary outcomes:
measure: Psychological stress response : State Trait Anxiety Inventory (STAI)
timeFrame: 1 year
Secondary outcomes:
measure: Clinical performance on cardiopulmonary arrest
timeFrame: 1 year
measure: Physiological stress response : Standard Deviation
timeFrame: 1 year
measure: Family meeting quality : Gather-Resources-Identify-Educate-Verify-Inquire-"Nuts and bolts"-Give
timeFrame: 1 year
measure: Non technical skills (NTS) : Crisis resource management ( CRM). Score Ottawa
timeFrame: 1 year
measure: Burnout Scale
timeFrame: 1 year
measure: Quality Of Life : WHOQoL
timeFrame: 1 year
measure: Psychological stress response
timeFrame: 1 year
Other outcomes:
Locations:
city: La Tronche
country: France
facility: University hospital Grenoble Alps
Study officials:
References:
Clinical trial NCT01411397: Mesh Hernioplasty Of Strangulated Hernias With Intestinal Resection
Official title: Mesh Hernioplasty Of Strangulated Hernias With Intestinal Resection
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Strangulated Hernia
Keywords: Infection
Prosthesis
Recurrence
Strangulation
Lead sponsor: Mansoura University
Sponsor class: OTHER
First posted: 2011-08-08
Enrollment: 163
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Primary suture repair increases the risk for recurrence, the fact of benefit of mesh repair in elective situations is documented, and many studies have reported beneficial outcomes of mesh hernioplasty in emergency situations. Still there is controversy of using such grafts in presence of intestinal resection.

Detailed description: Patients with acutely incarcerated hernias (with small intestine contents) who underwent polypropylene mesh hernioplasty were included in this prospective study from June 2005 through Jan. 2011, patients were categorized into 2 groups who required intestinal resection anastomosis (group I)or not (group II).

Eligibility criteria: Inclusion Criteria:

* strangulated hernias

Exclusion Criteria:

* above 75, under 18
* recurrent hernia
* peritonitis
* pure omentum contents ASA above 3

Primary outcomes:
measure: wound infection
timeFrame: 5 weeks
Secondary outcomes:
measure: operative time
timeFrame: 3hours
measure: morbidity
timeFrame: 5 months
measure: recurrence of the hernia
timeFrame: 6months
Other outcomes:
Locations:
city: Mansoura
country: Egypt
facility: Mohamed Abdellatif
Study officials:
affiliation: Mansoura University
name: ramadan ellithy, md
role: STUDY_DIRECTOR
References:
Clinical trial NCT00210197: Hypercoagulability After Breast Cancer Surgery
Official title: Plasma Coagulation Parameters and Hypercoagulability After Breast Cancer Surgery
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Breast Cancer
Blood Coagulation Disorders
Keywords: Hypercoagulability
Plasma coagulation parameters
Breast cancer
Lead sponsor: Institut Bergonié
Sponsor class: OTHER
First posted: 2005-09-21
Enrollment: 48
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Breast Cancer

Brief summary: The risk of deep venous thrombosis after radical breast surgery is known. The objective of this study is to explore hypercoagulability after radical breast cancer surgery by studying several factors for haemostasis before, during and after surgery. Ultrasound Doppler examination is realised between 24 and 72 hours post-operatively. Hypercoagulability is defined by a significant increasing level of thrombin-antithrombin, D-dimer and the endogen thrombin potential.


Eligibility criteria: Inclusion criteria:

* Breast cancer
* mastectomy

Exclusion criteria:

* thrombophilia
* anticoagulant treatment

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Bordeaux
country: France
facility: Institut Bergonié - Centre Régional de Luttre Contre le Cancer de Bordeaux et du Sud Ouest
Study officials:
affiliation: Institut Bergonié
name: Youssef KABBANI, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05627297: Applying Artificial Intelligence to Optimize Early-stage Hepatocellular Carcinoma Treatment Based on Multi-modal Image
Official title: Artificial Intelligence to Optimize Early-stage Hepatocellular CarcinomaTreatment Based on Multi-modal Image
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Hepatocellular Carcinoma
Lead sponsor: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
Sponsor class: OTHER
First posted: 2022-11-25
Enrollment: 200
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 200

Brief summary: This study intends to establish two prognostic models based on contrast-enhanced ultrasound (CEUS) and dynamic enhanced magnetic resonance (DE-MRI) multimodal images: prognostic model of liver cancer patients after hepatectomy and prognostic model of liver cancer patients after radiofrequency ablation. Combined with artificial intelligence imaging omics, traditional imaging omics and clinical information, to predict and compare the prognosis of two different treatment methods for early liver cancer, so as to realize the individual selection of treatment methods for early liver cancer patients


Eligibility criteria: Inclusion Criteria:

* Primary single hepatocellular carcinoma confirmed by histology or cytology, with a maximum diameter ≤5.0 cm;

  * Good liver function, Child-Pugh grade A;

    * No serious dysfunction of heart, lung, kidney and other important organs ④ Liver resection or radiofrequency ablation was performed in our hospital, and the study protocol and follow-up procedure were followed.

Exclusion Criteria:

* Patients who cannot perform DCE-MRI examination due to metal implants in the body ② Patients who had received other treatment before DCE-MRI or CEUS;

  * Invisible lesions, diffuse lesions or poor DCE-MRI/CEUS image quality under CEUS; ④ Drug abuse, clinical or psychological or social factors that make informed consent or study implementation affected.

Primary outcomes:
measure: Good/Poor overall survival
timeFrame: 2022/12/01-2025/12/01
Secondary outcomes:
Other outcomes:
Locations:
city: Nanjing
country: China
facility: Nanjing Drum Tower Hospital
state: Jiangsu
Study officials:
affiliation: The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School
name: Wentao Kong
role: STUDY_CHAIR
References:
Clinical trial NCT05441397: Prevalence of Periodontitis Based Upon Principles Presented by the 2017 Classification: A Hospital-based Cross-sectional Study on a Sample of Young Egyptian Dental Patients
Official title: Prevalence of Periodontitis Based Upon Principles Presented by the 2017 Classification: A Hospital-based Cross-sectional Study on a Sample of Young Egyptian Dental Patients
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Periodontitis
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2022-07-01
Enrollment: 464
Sex: ALL
Minimum age (years): 12
Maximum age (years): 39
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Young Egyptian dental outpatients attending the oral diagnosis clinic at faculty of Dentistry, Cairo University

Brief summary: The study aims at determining the Prevalence Of Periodontitis based upon principles presented by the 2017 Classification: A Hospital-Based Cross-Sectional Study on A Sample of Young Egyptian Dental Patients


Eligibility criteria: Inclusion Criteria:

1. Patients whose age from 12 to 39 years old .
2. Patient consulting in the outpatient clinic
3. Provide informed consent.

Exclusion Criteria:

1. Patients having problem in opening their mouth or undergoing inter maxillary fixation where oral examination will not be possible.
2. Patients diagnosed with psychiatric problems or intoxicated with alcohol or drugs

Primary outcomes:
measure: Probing pocket depth Staging & Grading
timeFrame: up to 1 day
measure: Clinical attachment level
timeFrame: up to 1 day
Secondary outcomes:
measure: Nutritional status
timeFrame: up to 1 day
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Cairo University
Study officials:
affiliation: Cairo University
name: Rana T EL-Hanify, BDs
role: PRINCIPAL_INVESTIGATOR
affiliation: lecturer of oral medicine and periodontology ,faculty of dentistry ,Cairo university
name: Nesma M Shemais, PHD
role: STUDY_DIRECTOR
affiliation: associate professor of oral medicine and periodontology ,faculty of dentistry ,Cairo university
name: Weam A el-battawy, PHD
role: STUDY_DIRECTOR
affiliation: professor of oral medicine and periodontology ,faculty of dentistry ,Cairo university
name: Manal M Hosny, PHD
role: STUDY_CHAIR
References: