Clinical trial NCT04497597: A Study of Oral Upadacitinib Tablets to Assess Treatment Patterns, Achievement of Treatment Targets and Maintenance of Response in Adult Participants With Moderate to Severe Rheumatoid Arthritis
Official title: Upadacitinib Treatment Patterns, Achievement of Treatment Targets and Maintenance of Response in Moderate to Severe Rheumatoid Arthritis Patients in Real-World Practice (UPHOLD)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Rheumatoid Arthritis (RA)
Keywords: Rheumatoid Arthritis
Upadacitinib
RINVOQ
Lead sponsor: AbbVie
Sponsor class: INDUSTRY
First posted: 2020-08-04
Enrollment: 1532
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adults receiving Upadacitinib according to the product prescribing information, for moderate to severe active Rheumatoid Arthritis (RA).

Brief summary: Rheumatoid Arthritis (RA) is an inflammatory disease of the joints causing pain, stiffness, swelling and loss of joint function. Despite the range of treatment options for RA steadily increasing, many patients remain sub-optimally managed, with sustained clinical remission rarely achieved. This study will assess the treatment patterns, achievement of treatment targets and maintenance of response.

Upadacitinib is a drug approved for the treatment of moderately to severely active rheumatoid arthritis. Adult participants with moderate to severe RA who have been prescribed upadacitinib by their physicians will be enrolled. Approximately, 1660 participants will be enrolled this study, worldwide.

Participants will not receive Upadacitinib as part of this study, but will be followed for response to treatment for up to 24 months.

There may be higher burden for participants in this trial compared to their standard of care. Participants will attend regular visits, every 3 months, during the course of the study at a hospital or clinic and will be asked to provide additional information by questionnaire at each visit.


Eligibility criteria: Inclusion Criteria:

* Confirmed diagnosis of moderate to severe active Rheumatoid Arthritis (RA).
* Physician decision on patient treatment with upadacitinib must have been reached prior to and independently of recruitment in the study.
* Upadacitinib prescribed in accordance to the applicable approved label and local regulatory and reimbursement policies.
* French Participants Only: Taking oral glucocorticoids ≥5 mg/day of prednisone or equivalent for at least 3 months prior to study start.

Exclusion Criteria:

- Prior treatment with Upadacitinib.

Primary outcomes:
measure: Percentage of Participants Who Achieve Remission
timeFrame: At Month 6
measure: Percentage of Participants Who Achieve Remission at 6 Months and Maintain Remission
timeFrame: At Month 12
Secondary outcomes:
measure: Percentage of Participants Who Achieve Remission at 6 Months and Maintain Remission
timeFrame: At Month 24
measure: Percentage of Participants Who Achieve Low Disease Activity (LDA) at 6 months that maintain LDA
timeFrame: Through Month 24
measure: Percentage of Participants Who Achieve Remission at 3 Months and Maintain Remission
timeFrame: Through Month 24
measure: Percentage of Participants Who Achieve Remission at 6 Months and Maintain Remission Grouped by Glucocorticoid Dose
timeFrame: At Month 12
measure: Percentage of Participants Who Achieve LDA at 3 months that maintain LDA Grouped by Glucocorticoid Dose
timeFrame: Through Month 6
measure: Percentage of Participants in LDA that Achieve Glucocorticoid Dose <5 mg/Day Per Visit
timeFrame: Through Month 24
measure: Percentage of Participants in Remission that Achieve Glucocorticoid Dose <5 mg/Day Per Visit
timeFrame: Through Month 24
measure: Percentage of Participants Who Achieved a Glucocorticoid Dose <5 mg/Day Without Conventional Synthetic Disease Modifying Anti Rheumatic Drug (csDMARD) Intensification
timeFrame: At Month 6
measure: Percentage of Participants Who Initiated Upadacitinib as Combination Therapy (csDMARD +/- Glucocorticoids) That Moved to Monotherapy (+/- Glucocorticoids)
timeFrame: Through Week 24
measure: Of the Participants Initiating Upadacitinib as Combination Therapy (csDMARD +/- Glucocorticoids) and Achieve Remission at 6 months, the Percentage of Participants that Maintain Remission Grouped by Maintenance of Combination Therapy Strategy
timeFrame: Through Month 24
measure: Of the Participants Initiating Upadacitinib as Combination Therapy (csDMARD +/- Glucocorticoids) and Achieve LDA at 6 months, the Percentage of Participants that Maintain LDA Grouped by Maintenance of Combination Therapy Strategy
timeFrame: Through Month 24
measure: Of the Participants Initiating Upadacitinib as Monotherapy Therapy (+/- Glucocorticoids) and Achieve Remission at 6 months, the Percentage of Participants that Maintain Remission Grouped by Maintenance of Monotherapy
timeFrame: Through Month 24
measure: Of the Participants Initiating Upadacitinib as Monotherapy Therapy (+/- Glucocorticoids) and Achieve LDA at 6 months, the Percentage of Participants that Maintain LDA Grouped by Maintenance of Monotherapy
timeFrame: Through Month 24
measure: Percentage of Participants Who Do Not Achieve Remission at Any Point in the Study
timeFrame: Through Month 24
measure: Time to the Discontinuation of Upadacitinib
timeFrame: Through Month 24
measure: Time to First Treatment Adjustment
timeFrame: Baseline (Month 0) Through Month 24
measure: Percentage of Participants Achieving LDA Grouped by Therapy Strategy
timeFrame: Through Month 24
measure: Percentage of Participants Achieving Remission Grouped by Therapy Strategy
timeFrame: Through Month 24
measure: Change in Medication Burden Treatment Burden Questionnaire (TBQ) in Participants, Grouped by Therapy Strategy
timeFrame: Through Week 24
measure: Change in Physical Function Health Assessment Questionnaire - Disability Index (HAQ-DI) in Participants, Grouped by Therapy Strategy
timeFrame: Baseline (Month 0) Through Month 24
measure: Change in Pain Visual Analogue Scale (VAS) in participants, Grouped by Therapy Strategy
timeFrame: Baseline (Month 0) Through Month 24
measure: Change in Morning Stiffness in Participants, Grouped by Therapy Strategy
timeFrame: Baseline (Month 0) Through Month 24
measure: Change in Functional Assessment of Chronic Illness Therapy - Fatigue (FACIT-F) in Participants, Grouped by Therapy Strategy
timeFrame: Baseline (Month 0) Through Month 24
Other outcomes:
Locations:
city: La Plata
country: Argentina
facility: Hospital Italiano La Plata /ID# 222190
state: Buenos Aires
city: Quilmes
country: Argentina
facility: CER Instituto Medico /ID# 222193
state: Buenos Aires
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: Organizacion Medica de Investigacion (OMI) /ID# 222187
state: Ciudad Autonoma De Buenos Aires
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: CIER Centro de Investigaciones en Enfermedades Reumaticas /ID# 231769
state: Ciudad Autonoma De Buenos Aires
city: Rosario
country: Argentina
facility: Instituto CAICI S.R.L /ID# 222191
state: Santa Fe
city: San Miguel de Tucuman
country: Argentina
facility: CIMER Centro Integral de Medicina Respiratoria /ID# 222188
state: Tucuman
city: Buenos Aires
country: Argentina
facility: DOM Centro de Reumatologia /ID# 222194
city: Cordoba
country: Argentina
facility: Instituto Medico Strusberg /ID# 222189
city: Santiago Del Estero
country: Argentina
facility: Instituto de Cardiologia /ID# 226634
city: Broadmeadow
country: Australia
facility: Genesis Research Services /ID# 224060
state: New South Wales
city: Paramatta
country: Australia
facility: BJC Health /ID# 223884
state: New South Wales
city: Adelaide
country: Australia
facility: Private Practice - Scott Walter Graf /ID# 223958
state: South Australia
city: Camberwell
country: Australia
facility: Emeritus Research /ID# 223883
state: Victoria
city: Murdoch
country: Australia
facility: Joint West Rheumatology /ID# 223886
state: Western Australia
city: Klagenfurt am Wörthersee
country: Austria
facility: Klinikum Klagenfurt am Wörthersee /ID# 239628
state: Kaernten
city: Hollabrunn
country: Austria
facility: Ordination Dr. Leeb /ID# 224293
state: Niederoesterreich
city: Gleisdorf
country: Austria
facility: Dr. Georg Kurtz /ID# 225477
state: Steiermark
city: Vienna
country: Austria
facility: Dr. Maya Thun /ID# 224299
state: Wien
city: Vienna
country: Austria
facility: Ordination Doz. Grisar /ID# 224298
state: Wien
city: Vienna
country: Austria
facility: Rheuma-Zentrum Wien-Oberlaa GmbH /ID# 227853
state: Wien
city: Bruxelles
country: Belgium
facility: CHU Saint Pierre /ID# 223041
state: Bruxelles-Capitale
city: Charleroi
country: Belgium
facility: Rhumaconsult SPRL /ID# 221825
state: Hainaut
city: Hasselt
country: Belgium
facility: Reuma Instituut Hasselt /ID# 221822
state: Limburg
city: Godinne
country: Belgium
facility: Duplicate_CHU UCL Namur - site Godinne /ID# 222797
state: Namur
city: Aalst
country: Belgium
facility: Algemeen Stedelijk Ziekenhuis /ID# 224121
state: Oost-Vlaanderen
city: Sint-Niklaas
country: Belgium
facility: Private practice Sint-Niklaas /ID# 224123
state: Oost-Vlaanderen
city: Aalst
country: Belgium
facility: Onze Lieve Vrouw Hospital /ID# 223042
city: Brugge
country: Belgium
facility: AZ Sint-Jan Brugge /ID# 223713
city: Brugge
country: Belgium
facility: AZ Sint Lucas /ID# 223093
city: Genk
country: Belgium
facility: Reumacentrum /ID# 222799
city: Genk
country: Belgium
facility: ReumaClinic /ID# 221353
city: Gistel
country: Belgium
facility: Maertens, Gistel, BE /ID# 221823
city: Liege
country: Belgium
facility: CHU de Liege /ID# 222201
city: Sijsele
country: Belgium
facility: AZ Alma Campus Sijsele /ID# 222214
city: Laon CEDEX
country: France
facility: Centre Hospitalier de Laon /ID# 224857
state: Aisne
city: Moulins
country: France
facility: Polyclinique saint Odilon /ID# 225576
state: Allier
city: Cannes CEDEX
country: France
facility: CH Cannes - les Broussailles /ID# 226160
state: Alpes-Maritimes
city: Strasbourg
country: France
facility: CHU Strasbourg - Hopital de Hautepierre /ID# 222450
state: Bas-Rhin
city: Marseille
country: France
facility: Hopital Saint Joseph /ID# 227221
state: Bouches-du-Rhone
city: Caen
country: France
facility: cabinet liberal- Dr CORNILLE /ID# 227869
state: Calvados
city: Angouleme CEDEX 9
country: France
facility: Centre Hospitalier d'Angouleme /ID# 226064
state: Charente
city: Dijon
country: France
facility: CHU Dijon /ID# 223799
state: Cote-d Or
city: Niort CEDEX
country: France
facility: CH Georges Renon /ID# 225197
state: Deux-Sevres
city: Besancon
country: France
facility: CHU de Besancon - Jean Minjoz /ID# 222463
state: Doubs
city: Mennecy
country: France
facility: Cabinet de rhumatologie /ID# 227740
state: Essonne
city: St Michel Sur Orge
country: France
facility: Cabinet Rhumatologie St Michel Sur Orge /ID# 225176
state: Essonne
city: Brest
country: France
facility: Hopital de la Cavale Blanche /ID# 222462
state: Finistere
city: Morlaix
country: France
facility: CH des Pays de Morlaix /ID# 223795
state: Finistere
city: Limoges CEDEX 1
country: France
facility: CHU Limoges - Dupuytren 1 /ID# 222457
state: Franche-Comte
city: Bordeaux
country: France
facility: CHU Bordeaux - Hopital Pellegrin /ID# 224837
state: Gironde
city: TOULOUSE Cedex 9
country: France
facility: CHU Toulouse - Hopital Purpan /ID# 223150
state: Haute-Garonne
city: Tarbes CEDEX 9
country: France
facility: CH Bigorre - Site de la Gespe /ID# 225141
state: Hautes-Pyrenees
city: Roubaix Cedex 1
country: France
facility: CH Roubaix - Hopital Victor Provo /ID# 225032
state: Hauts-de-France
city: Montpellier Cedex 5
country: France
facility: CHU Montpellier - Hopital Saint Eloi /ID# 222452
state: Herault
city: Montpellier Cedex 5
country: France
facility: CHU Montpellier - Hopital Saint Eloi /ID# 223394
state: Herault
city: Montpellier
country: France
facility: Clinique Beau Soleil /ID# 224238
state: Herault
city: Bobigny
country: France
facility: Hopital Avicenne - APHP /ID# 224248
state: Ile-de-France
city: La Tronche
country: France
facility: CHU Grenoble - Hopital Michallon /ID# 223211
state: Isere
city: Les Abrets En Dauphine
country: France
facility: Cabinet médical /ID# 225000
state: Isere
city: Roanne
country: France
facility: CH Roanne /ID# 224729
state: Loire
city: Reims
country: France
facility: Cabinet médical /ID# 225321
state: Marne
city: Thionville
country: France
facility: Cabinet de Rhumatologie Poincare /ID# 224755
state: Moselle
city: Compiegne
country: France
facility: Cabinet liberal - Compiegne - Dr Banse /ID# 227099
state: Oise
city: Paris CEDEX 14
country: France
facility: Hopitaux Universitaires Paris Centre-Hopital Cochin /ID# 222986
state: Paris
city: Nantes
country: France
facility: CHU de Nantes, Hotel Dieu -HME /ID# 225787
state: Pays-de-la-Loire
city: Nice CEDEX 1
country: France
facility: CHU Nice -Hopital Pasteur /ID# 222460
state: Provence-Alpes-Cote-d Azur
city: Caluire Et Cuire
country: France
facility: Infirmerie Protestante /ID# 222438
state: Rhone
city: Pierre Benite CEDEX
country: France
facility: HCL - Hopital Lyon Sud /ID# 222447
state: Rhone
city: Aix les Bains
country: France
facility: Cabinet medical /ID# 225366
state: Savoie
city: Amiens CEDEX 1
country: France
facility: CHU Amiens-Picardie Site Sud /ID# 222444
state: Somme
city: Peronne
country: France
facility: Cabinet libéral du Dr PAUPIERE /ID# 238723
state: Somme
city: Albi
country: France
facility: Cabinet medical /ID# 224850
state: Tarn
city: La Roche Sur Yon
country: France
facility: CHD Vendée- La Roche-sur-Yon - Les Oudairies /ID# 229086
state: Vendee
city: Aix En Provence Cedex 1
country: France
facility: CH du Pays d'AIX /ID# 229561
city: Annecy
country: France
facility: Cabinet Novel d'Annecy /ID# 232310
city: Arras
country: France
facility: Centre Hospitalier d'Arras /ID# 223172
city: Boulogne sur Mer
country: France
facility: Centre Hospitalier de Boulogne Sur Mer /ID# 222991
city: Cahors
country: France
facility: Centre Hospitalier Jean Rougie /ID# 224242
city: Chambray Les Tours
country: France
facility: CHRU Tours - Hopital Trousseau /ID# 222445
city: Cholet
country: France
facility: Centre Hospitalier de CHOLET /ID# 222455
city: Clamart
country: France
facility: Hia Percy /Id# 225642
city: Clermont Ferrand
country: France
facility: CHU Clermont Ferrand - Hopital Gabriel Montpied /ID# 223801
city: Corbeil Essonnes
country: France
facility: C. H. Sud Francilien /ID# 222446
city: Haguenau
country: France
facility: Cabinet medical /ID# 225142
city: La Rochelle
country: France
facility: CH La Rochelle - Hopital Saint Louis /ID# 224240
city: Le Puy en Velay
country: France
facility: CH Emile Roux Le Puy en Velay /ID# 223688
city: Lille
country: France
facility: CHU Lille - Hôpital Roger Salengro /ID# 223170
city: Lyon
country: France
facility: Clinique de la Sauvegarde /ID# 223424
city: Monaco
country: France
facility: CH Princesse Grace /ID# 222451
city: Montauban
country: France
facility: Ch Montauban /Id# 231854
city: Montauban
country: France
facility: ELSAN - Clinique du Pont de Chaume /ID# 224898
city: Mulhouse
country: France
facility: Ch Mulhouse /Id# 223442
city: Orléans
country: France
facility: Centre Hospitalier Régional d'Orléans - Hôpital de la Source /ID# 223591
city: Paris
country: France
facility: AP-HP - Hopital Saint-Antoine /ID# 222441
city: Paris
country: France
facility: Hopital Pitie Salpetriere /ID# 222443
city: Paris
country: France
facility: Cabinet medical /ID# 224855
city: Paris
country: France
facility: Centre de Soins Osteoarticulaires Ambulatoires /ID# 224737
city: Paris
country: France
facility: AP-HP - Hopital Bichat - Claude-Bernard /ID# 222449
city: Paris
country: France
facility: GH Diaconesses Croix Saint-Simon /ID# 229126
city: Rennes CEDEX 2
country: France
facility: CHU de Rennes - Hospital Sud /ID# 222458
city: Rouen
country: France
facility: Clinique Saint-Hilaire /ID# 223833
city: Rouen
country: France
facility: Hôpital Charles-Nicolle /ID# 223589
city: Saint-Mandé cedex
country: France
facility: Hôpital d'instruction des armées Bégin /ID# 222440
city: Sainte Maxime
country: France
facility: Cabinet rhumatologie Dr NECTOUX /ID# 225828
city: St Nazaire
country: France
facility: CH Saint Nazaire /ID# 225750
city: St-Priest-en-Jarez
country: France
facility: Centre Hospitalier Universitaire de Saint Étienne - Hôpital Nord /ID# 222456
city: Strasbourg
country: France
facility: Groupe Médical Spécialisé - Le Premium /ID# 223719
city: Tuebingen
country: Germany
facility: Praxis Dr. Haas /ID# 225187
state: Baden-Wuerttemberg
city: Templin
country: Germany
facility: Rheumatologische-Immunologische Praxis Templin /ID# 226924
state: Brandenburg
city: Baden-baden
country: Germany
facility: ACURA Rheumazentrum Baden-Bade /ID# 225225
city: Bamberg
country: Germany
facility: Rheumapraxis Prof Dr Karin Manger /ID# 224086
city: Berlin
country: Germany
facility: Praxis fuer Rheumatologie und Innere Medizin /ID# 225222
city: Braunschweig
country: Germany
facility: Eisterhues, Braunschweig, DE /ID# 225186
city: Cologne
country: Germany
facility: Rheumatologie in Veedel /ID# 224999
city: Cologne
country: Germany
facility: Dres. Karger/Baerlecken /ID# 224809
city: Ehringshausen
country: Germany
facility: Praxis Dilltal /ID# 226925
city: Erfurt
country: Germany
facility: MVZ Ambulantes Rheumazentrum Erfurt /ID# 224812
city: Gommern
country: Germany
facility: Helios Fachklinik Vogelsang-Gommern /ID# 222949
city: Hamburg
country: Germany
facility: Asklepios MVZ Nord SH GmbH /ID# 225048
city: Heidelberg
country: Germany
facility: Heilig, Heidelberg, DE /ID# 225223
city: Leipzig
country: Germany
facility: Praxis internistische Rheumatologie /ID# 239226
city: Leverkusen
country: Germany
facility: Dres. Teipel/Toussaint/Saech /ID# 226923
city: Magdeburg
country: Germany
facility: Aurich & Sieburg, Magdeburg /ID# 230701
city: Pfarrkirchen
country: Germany
facility: Die Fachaerzte im Rottal - Nephrologie, Rheumatologie /ID# 223866
city: Planegg
country: Germany
facility: MVZ für Rheumatologie Dr. M. Welcker /ID# 226926
city: Trier
country: Germany
facility: Krankenhaus der Barmherzigen Brüder Trier /ID# 226927
city: Patras
country: Greece
facility: Olympion General Clinic /ID# 224130
state: Achaia
city: Athens
country: Greece
facility: 251 Airforce General Hospital /ID# 225065
state: Attiki
city: Athens
country: Greece
facility: General Hospital of Athens Gennimatas /ID# 225064
state: Attiki
city: Athens
country: Greece
facility: General Hospital of Athens Ippokratio /ID# 224164
state: Attiki
city: Athens
country: Greece
facility: University General Hospital Attikon /ID# 224136
state: Attiki
city: Athens
country: Greece
facility: General Hospital Asklepieio Voulas /ID# 224131
state: Attiki
city: Alexandroupoli
country: Greece
facility: University General Hospital of Alexandroupolis /ID# 224880
state: Evros
city: Heraklion
country: Greece
facility: University General Hospital of Heraklion PA.G.N.I /ID# 224133
state: Kriti
city: Athens
country: Greece
facility: Naval Hospital of Athens /ID# 224135
city: Patras
country: Greece
facility: General Hospital of Patras Agios Andreas /ID# 224132
city: Thessaloniki
country: Greece
facility: Bioclinic Thessaloniki /ID# 224879
city: Thessaloniki
country: Greece
facility: General Hospital of Thessaloniki Hippokrateio /ID# 229965
city: Thessaloniki
country: Greece
facility: Euromedica General Clinic /ID# 224134
city: Dublin 20
country: Ireland
facility: Hermitage Medical Clinic /ID# 239556
state: Dublin
city: Dublin 8
country: Ireland
facility: St James Hospital /ID# 224201
state: Dublin
city: Elm Park
country: Ireland
facility: St Vincent's University Hospital /ID# 224200
state: Dublin
city: Tallaght
country: Ireland
facility: Tallaght University Hospital /ID# 231260
state: Dublin
city: Afula
country: Israel
facility: HaEmek Medical Center /ID# 222138
state: H_efa
city: Hadera
country: Israel
facility: Hillel Yaffe Medical Center /ID# 222170
state: H_efa
city: Haifa
country: Israel
facility: Rambam Health Care Campus /ID# 222118
state: H_efa
city: Haifa
country: Israel
facility: The Lady Davis Carmel Medical Center /ID# 223851
state: H_efa
city: Kfar Saba
country: Israel
facility: Meir Medical Center /ID# 222116
state: HaMerkaz
city: Nahariya
country: Israel
facility: Galilee Medical Center /ID# 222113
state: HaTsafon
city: Ramat Gan
country: Israel
facility: The Chaim Sheba Medical Center /ID# 222034
state: Tel-Aviv
city: Tel Aviv
country: Israel
facility: Tel Aviv Sourasky Medical Center /ID# 222117
state: Tel-Aviv
city: Haifa
country: Israel
facility: Rabin Medical Center /ID# 222694
city: Torette
country: Italy
facility: Azienda Ospedaliero Universitaria Ospedali Riuniti Do Ancona /ID# 229440
state: Ancona
city: Cona
country: Italy
facility: Azienda Ospedaliero Universitaria di Ferrara - Ospedale Sant'Anna /ID# 228788
state: Ferrara
city: Arenzano
country: Italy
facility: ASL 3 Genovese - Ospedale la Colletta /ID# 228892
state: Genova
city: Rome
country: Italy
facility: Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Universita Cattolica /ID# 229061
state: Lazio
city: Milan
country: Italy
facility: Ospedale San Raffaele IRCCS /ID# 229059
state: Milano
city: Milan
country: Italy
facility: ASST Grande Ospedale Metropolitano Niguarda /ID# 228807
state: Milano
city: Rozzano
country: Italy
facility: Istituto Clinico Humanitas /ID# 227943
state: Milano
city: Rome
country: Italy
facility: Fondazione Policlinico Universitario Campus Bio-Medico di Roma /ID# 229063
state: Roma
city: Rome
country: Italy
facility: Sapienza University /ID# 228014
state: Roma
city: Turin
country: Italy
facility: Ospedale Mauriziano di Torino /ID# 228888
state: Torino
city: Alessandria
country: Italy
facility: Azienda Ospedaliera Nazionale SS. Antonio e Biagio e Cesare Arrigo /ID# 228889
city: Bari
country: Italy
facility: Azienda Ospedaliera Universitaria Consorziale Policlinico /ID# 228580
city: Bergamo
country: Italy
facility: Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII (Presidio Papa Giovanni /ID# 228967
city: Brescia
country: Italy
facility: ASST Spedali civili di Brescia /ID# 228970
city: Chieti
country: Italy
facility: Ospedale Ss. Annunziata /ID# 228809
city: Milan
country: Italy
facility: ASST Gaetano Pini/Presidio Ospedaliero Pini /ID# 228556
city: Modena
country: Italy
facility: Azienda Ospedaliero-Universitaria di Modena /ID# 228554
city: Napoli
country: Italy
facility: AOU Universita degli Studi della Campania Luigi Vanvitelli /ID# 229057
city: Napoli
country: Italy
facility: Ospedale San Giovanni Bosco /ID# 228552
city: Palermo
country: Italy
facility: Azienda Ospedaliera Civico Di Cristina Benfratelli- P.O. Civico /ID# 228912
city: Palermo
country: Italy
facility: Azienda Ospedaliera Universitaria Paolo Giaccone /ID# 228160
city: Pavia
country: Italy
facility: Fondazione IRCCS Policlinico /ID# 227937
city: Pisa
country: Italy
facility: Azienda Ospedaliero Universitaria Pisana /ID# 228550
city: Potenza
country: Italy
facility: Azienda Ospedaliera Regionale San Carlo /ID# 228648
city: Rome
country: Italy
facility: Azienda Ospedaliero-Universitaria Sant'Andrea /ID# 227942
city: Salerno
country: Italy
facility: Azienda Ospedaliera Universitaria "San Giovanni di Dio e Ruggi d'Aragona /ID# 229065
city: Siena
country: Italy
facility: Azienda Ospedaliero-Universitaria Senese-Ospedale Santa Maria delle Scotte /ID# 227938
city: Udine
country: Italy
facility: Azienda Ospedaliera Universitaria Friuli Centrale/Presidio Ospedaliero Universit /ID# 228551
city: Verona
country: Italy
facility: Azienda Ospedaliera Universitaria di Verona/Ospedale Borgo Trento /ID# 228553
city: Hawalli
country: Kuwait
facility: Mubarak Hospital /ID# 224139
city: Kuwait City
country: Kuwait
facility: Ameeri Hospital /ID# 224140
city: Kuwait
country: Kuwait
facility: KOC Hospital /ID# 224138
city: Mexico City
country: Mexico
facility: RM Pharma Specialists S.A de C.V. /ID# 224359
state: Ciudad De Mexico
city: Mexico City
country: Mexico
facility: CINTRE, Centro de Investigación y Tratamiento Reumatológico SC /ID# 240836
state: Ciudad De Mexico
city: Guadalajara
country: Mexico
facility: Centro Integral en Reumatologia S.A de C.V /ID# 224363
state: Jalisco
city: Guadalajara
country: Mexico
facility: Clinica de Investigacion en Reumatologia y Obesidad S.C. /ID# 224361
state: Jalisco
city: Guadalajara
country: Mexico
facility: Private Office Dr. Orozco /ID# 243257
state: Jalisco
city: Guadalajara
country: Mexico
facility: Centro de Estudios de Investigación Básica y Clínica, S.C. /ID# 224364
state: Jalisco
city: Monterrey
country: Mexico
facility: Consultorio Medico Privado - Miryam Eguia Bernal /Id# 243255
state: Nuevo Leon
city: Mexico City
country: Mexico
facility: Centro Especializado en Diabetes, Obesidad y Prevencion de Enfermedades Cardiova /ID# 224360
city: Puebla
country: Mexico
facility: Consultorio Privado Jorge Rojas Serrano /Id# 243258
city: Syktyvkar
country: Russian Federation
facility: LLC MC RevmaMed /ID# 239162
state: Komi, Respublika
city: Moscow
country: Russian Federation
facility: Moscow Regional Research and Clinical Institute n.a. Vladimirskiy (MONIKI) /ID# 224852
state: Moskovskaya Oblast
city: Samara
country: Russian Federation
facility: Samara Regional Clinical Hospital n.a. V. D. Seredavin /ID# 227852
state: Samarskaya Oblast
city: St. Petersburg
country: Russian Federation
facility: Nort-Western State Medical University n.a. Mechnikov /ID# 223419
state: Sankt-Peterburg
city: Tyumen
country: Russian Federation
facility: GBUZ TO Regional Clinical Hospital No. 1 /ID# 241113
state: Tyumenskaya Oblast
city: Khanty-Mansyisk
country: Russian Federation
facility: District clinical hospital /ID# 227662
city: Moscow
country: Russian Federation
facility: City Clinical Hospital #52 /ID# 242947
city: Omsk
country: Russian Federation
facility: Omsk Regional Clinic Hospital /ID# 232029
city: Orenburg
country: Russian Federation
facility: Orenburg State Medical University /ID# 243615
city: Petrozavodsk
country: Russian Federation
facility: Republican hospital named after V.A. Baranov /ID# 227661
city: Samara
country: Russian Federation
facility: Clinic of Samara State Medical University /ID# 241168
city: St. Petersburg
country: Russian Federation
facility: Clinical Rheumatologic Hospital No 25 /ID# 242475
city: St. Petersburg
country: Russian Federation
facility: Military Medical Academy n.a. Kirov /ID# 242351
city: Surgut
country: Russian Federation
facility: Budgetary Institution of the Khanty-Mansiysk Autonomous Okrug-Yugra Surgut Dist /ID# 243313
city: Tomsk
country: Russian Federation
facility: Nebbiolo Clinical Research Center /ID# 224900
city: Ulyanovsk
country: Russian Federation
facility: Ulyanovsk Regional Clinical Hospital /ID# 239164
city: Voronezh
country: Russian Federation
facility: Voronezh State Medical Univers /ID# 224854
city: Yaroslavl
country: Russian Federation
facility: Yaroslavl State Medicat University /ID# 224851
city: Jeddah
country: Saudi Arabia
facility: Saudi German Hospital Jeddah /ID# 243234
city: Jeddah
country: Saudi Arabia
facility: King Abdulaziz University Hospital /ID# 222724
city: Jeddah
country: Saudi Arabia
facility: International Medical Center /ID# 243235
city: Mushait
country: Saudi Arabia
facility: Saudi German Hospital /ID# 224137
city: Riyadh
country: Saudi Arabia
facility: King Fahad Medical City /ID# 222917
city: A Coruña
country: Spain
facility: Complejo Hospitalario Universitario A Coruña /ID# 231818
state: A Coruna
city: Mérida
country: Spain
facility: Hospital de Mérida /ID# 231826
state: Badajoz
city: Terrassa
country: Spain
facility: Hospital Universitari Mútua Terrassa /ID# 231822
state: Barcelona
city: Viladecans
country: Spain
facility: Hospital de Viladecans /ID# 231823
state: Barcelona
city: Plasencia
country: Spain
facility: Hospital Virgen del Puerto /ID# 240149
state: Caceres
city: Jerez de la Frontera
country: Spain
facility: Hospital Universitario de Jerez de la Frontera /ID# 231844
state: Cadiz
city: Córdoba
country: Spain
facility: Hospital Universitario Reina Sofia /ID# 231843
state: Cordoba
city: Getafe
country: Spain
facility: Hospital Universitario de Getafe /ID# 231825
state: Madrid
city: Cartagena
country: Spain
facility: Hospital General Universitario Santa Lucia /ID# 238780
state: Murcia
city: El Palmar
country: Spain
facility: Hospital Clinico Universitario Virgen de la Arrixaca /ID# 231847
state: Murcia
city: Lorca
country: Spain
facility: Hospital Rafael Mendez /ID# 231846
state: Murcia
city: Vigo
country: Spain
facility: Hospital Xeral Cies (CHUVI) /ID# 231819
state: Pontevedra
city: San Cristóbal de La Laguna
country: Spain
facility: Hospital Universitario Canarias /ID# 231848
state: Santa Cruz De Tenerife
city: Calatayud
country: Spain
facility: Hospital Ernest Lluch Martin /ID# 238779
state: Zaragoza
city: Almeria
country: Spain
facility: Hospital Universitario Torrecardenas /ID# 241931
city: Badajoz
country: Spain
facility: Hospital Perpetuo Socorro /ID# 231827
city: Barcelona
country: Spain
facility: Hospital Parc de Salut del Mar /ID# 240000
city: Barcelona
country: Spain
facility: Hospital Santa Creu i Sant Pau /ID# 231821
city: Barcelona
country: Spain
facility: Hospital General de Granollers /ID# 238778
city: Granada
country: Spain
facility: Hospital Universitario Virgen de las Nieves /ID# 231841
city: Huelva
country: Spain
facility: Hospital Juan Ramon Jimenez /ID# 231840
city: Jaen
country: Spain
facility: Hospital Universitario de Jaen /ID# 231842
city: Madrid
country: Spain
facility: Hospital Universitario Ramon y Cajal /ID# 241901
city: Malaga
country: Spain
facility: Hospital Universitario Virgen de la Victoria /ID# 240150
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen Macarena /ID# 231837
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen del Rocio /ID# 231836
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen de Valme /ID# 231838
city: Zaragoza
country: Spain
facility: Hospital Royo Villanova /ID# 231824
city: Aarau
country: Switzerland
facility: Kantonsspital Aarau AG /ID# 222354
state: Aargau
city: Basel Town
country: Switzerland
facility: Universitätsspital Basel /ID# 224160
state: Basel-Stadt
city: St. Gallen
country: Switzerland
facility: Kantonsspital St. Gallen /ID# 224158
state: Sankt Gallen
city: Weinfelden
country: Switzerland
facility: Rheumatologisches Versorgungszentrum Weinfelden /ID# 222346
state: Thurgau
city: Lausanne
country: Switzerland
facility: CHUV, Centre hospitalier universitaire vaudois /ID# 224161
state: Vaud
city: Bern
country: Switzerland
facility: Inselspital, Universitaetsspital Bern /ID# 224951
city: Fribourg
country: Switzerland
facility: HFR Fribourg - Hôpital cantonal /ID# 224163
city: Taipei City
country: Taiwan
facility: National Taiwan University Hospital /ID# 241050
state: Taipei
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Medical University Chung-Ho Memorial Hospital /ID# 241052
city: Taichung
country: Taiwan
facility: China Medical University Hospital /ID# 241051
city: Tainan
country: Taiwan
facility: Chi-Mei Medical Center /ID# 241745
city: Taipei City
country: Taiwan
facility: Tri-Service General Hospital /ID# 241746
city: Taoyuan City
country: Taiwan
facility: Linkou Chang Gung Memorial Hospital /ID# 241053
city: Abu Dhabi
country: United Arab Emirates
facility: Cleveland Clinic Abu Dhabi /ID# 223176
city: Dubai
country: United Arab Emirates
facility: Integrated Rheumatology and Arthritis Center /ID# 223177
city: Dubai
country: United Arab Emirates
facility: Departnent of Medicine-Rheumatology Al Baraha Hospital and Al Qasmi Hospital Min /ID# 223178
city: Dubai
country: United Arab Emirates
facility: Drt Sulaiman Al Habib Hospital /ID# 226575
city: Montevideo
country: Uruguay
facility: Asociacion Española /ID# 222009
city: Montevideo
country: Uruguay
facility: Medica Uruguaya /ID# 222008
Study officials:
affiliation: AbbVie
name: ABBVIE INC.
role: STUDY_DIRECTOR
References: