louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03550898: Can Dynamic Ultrasonography Replace Urodynamics in Follow-up of Patients With Myelomeningocele
Official title: Can Dynamic Ultrasonography Replace Urodynamics in the Follow-up of Patients With Myelomeningocele: A Prospective Concurrent Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Neurogenic Bladder
Myelomeningocele
Keywords: Dynamic Ultrasonography
Spinal Dysraphism
Lead sponsor: Hospital de Clinicas de Porto Alegre
Sponsor class: OTHER
First posted: 2018-06-08
Enrollment: 81
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Dynamic ultrasonography was performed in all patients during the urodynamic study.
Primary purpose: DIAGNOSTIC

Brief summary: Patients with neurogenic bladder need periodic evaluation with urodynamic study, a invasive and uncomfortable procedure.

Aim: To evaluate the accuracy of dynamic ultrasonography as a feasible and noninvasive alternative diagnostic method to identify detrusor overactivity in patients with neurogenic bladder

Detailed description: The urodynamic study and dynamic ultrasonography were performed concurrently, to identify detrusor overactivity, in patients with myelomeningocele and clinical indication for urodynamics, by investigators without verbal or visual contact.

The overactivity was diagnosed through active conformational change of the bladder during filling phase.

Eligibility criteria: Inclusion Criteria:

* All outpatients of the Pediatric Urology Department of the investigator's institution with diagnosis of myelomeningocele and clinical indication for urodynamic study

Exclusion Criteria:

* Previous bladder augmentation surgery
* Current urinary tract infection
* Fail to provide consent for participation

Primary outcomes:
measure: To evaluate the accuracy of dynamic ultrasonography to identify bladder overactivity in neurogenic bladder.
timeFrame: 20 minutes
Secondary outcomes:
measure: To evaluate the accuracy of dynamic ultrasonography to identify maximum cystometric capacity.
timeFrame: 20 minutes
measure: To assess the ability of dynamic ultrasonography to estimate the pressure of detrusor contractions.
timeFrame: 20 minutes
Other outcomes:
Locations:
Study officials:
affiliation: Hospital de Clinicas de Porto Alegre
name: Brasil S Neto
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06614998: Establishment of an Early Warning Screening System for Hemophagocytic Lymphohistiocytosis a Multi-center, Prospective Study
Official title: Establishment of an Early Warning Screening System for Hemophagocytic Lymphohistiocytosis: a Multi-center, Prospective Study
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Hemophagocytic Syndrome
Keywords: hemophagocytic syndrome screening system
Lead sponsor: The Affiliated Hospital of Xuzhou Medical University
Sponsor class: OTHER
First posted: 2024-09-26
Enrollment: 80
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: A three-step screening process identified 80 people with suspected hemophagocytic syndrome

Brief summary: Our three-step screening system uses commonly used clinical and laboratory parameters to effectively identify patients who may be at high risk of HLH, conduct etiology screening early for patients who meet the diagnostic criteria for HLH, and guide standardized treatment. Therefore, this study proposes to establish a highly accurate and convenient hemophagocytic early warning system to improve the early diagnosis of patients with hemophagocytic syndrome and identify suspected HLH patients early. Etiology screening is performed on patients who meet the diagnostic criteria for HLH, high-risk predisposing factors are identified, and precise treatment is guided, thereby improving the success rate of patient treatment and improving the quality of life.


Eligibility criteria: Inclusion Criteria:

Subjects must meet all of the following criteria:

1. Patients who meet the first step screening + have ≥ 3 abnormal screening indicators in the second step
2. Patients who meet the first step screening + have 2 abnormal screening indicators in the second step + patients with high-risk factors for HLH, such as history of lymphoma, EBV infection, autoimmune diseases, etc

Exclusion Criteria:

Exclusion Criteria Subjects who meet one of the following criteria will not be enrolled: 1. Patients with liver cirrhosis, liver cancer, and hepatic encephalopathy 2. Patients with trauma, hepatosplenic rupture and other organ hemorrhage 3. Patients with severe disease such as shock, sepsis, and multiple organ failure 4. Patients with DIC 5. Patients with long-term anemia 6. Patients with acute promyelocytic leukemia 7. Patients with idiopathic deafness 8. Patients who have taken hormones/immunosuppressants 72 hours before admission 9. Hereditary fibrinogen deficiency

Primary outcomes:
measure: The suspected patient was diagnosed with hemophagocytic syndrome after complete NK cell activity, triglyceride tests, etc.
timeFrame: Time forecasting:2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Xuzhou
country: China
facility: Affilitated Hospital of Xuzhou Medical University
state: Jiangsu
Study officials:
References:
Clinical trial NCT00000298: Buprenorphine Combination Tablet Feasibility - 1
Official title: Buprenorphine Combination Tablet Feasibility
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Opioid-Related Disorders
Lead sponsor: National Institute on Drug Abuse (NIDA)
Sponsor class: NIH
First posted: 1999-09-21
Enrollment: 0
Sex: ALL
Minimum age (years): 21
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine target dose range of buprenorphine/naloxone combination tablet that provides therapeutic response in opiate addicts with low to moderate dependence, and to identify appropriate initial induction dose in opiate addicts with low to moderate dependence."


Eligibility criteria: Inclusion Criteria:

Males/Females ages 21-50, opiate dependence according to DSM-IV criteria, self-reported use within the last 30 days, agreeable to conditions of study and signed informed consent

Exclusion Criteria:

Psychiatric disorder that requires medication therapy, history of seizures, pregnant and/or nursing women, dependence on etoh or benzodiazepines or other sedative-hypnotics, acute hepatitis, other medical conditions that deem participation to be unsafe.

Primary outcomes:
measure: Withdrawal symptoms
measure: Opiate use
measure: Opiate craving
Secondary outcomes:
Other outcomes:
Locations:
city: Los Angeles
country: United States
facility: Friends Research Institute
state: California
Study officials:
affiliation: Friends Research Institute, Inc.
name: Walter Ling, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Buprenorphine/nalaxone cmbination tablet: First clinical experience (j. Add Dis 1997, in press). Buprenorphine/naloxone combination tablet: First clincial experience (J Add Dis 1997, in press).
Clinical trial NCT00784498: Procedural Sedation Using Propofol Versus Midazolam/Ketamine in the Adult Emergency Department
Official title: Procedural Sedation for Painful Orthopedic Manipulations With Propofol vs. Midazolam/Ketamine in the Adult Emergency Department
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Procedural Sedation
Keywords: Procedural sedation and analgesia
Emergency Department
propofol versus ketamine and midazolam
painful orthopedic manipulations
Lead sponsor: Tel-Aviv Sourasky Medical Center
Sponsor class: OTHER_GOV
First posted: 2008-11-04
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The use of procedural sedation and analgesia (PSA) to accomplish painful procedures in the emergency department (ED) has become a standard of practice over the last decade. Substantial variance exists regarding usage of medication for PSA, and many anesthetic agents have been proposed for this use.

To our knowledge no head to head study compared the clinical effectiveness, safety profile and amnestic properties of midazolam/ketamine vs. propofol regimens for PSA in the adult ED setting.

This prospective randomized trail can will help to evaluate the effectiveness and safety profile of Midazolam/katamine regimen for ED PSA in adults and will contribute to the discussion regarding propofol roll in the ED.


Eligibility criteria: Inclusion Criteria:

* Patients with orthopedic injuries requiring painful manipulation (i.e. reduction of fracture or dislocation, drainage of abscess, suture of extensive laceration)
* Age between18-65 years
* American Society of Anesthesiologists (ASA) score of 1 or 2
* Systolic blood pressure higher than 90 mmHg and lower than 160 mmHg before initiating sedation
* Willingness and ability to provide an informed consent
* No known hypersensitivity to either medication
* No evidence of intoxication
* No recent heavy meal.

Exclusion Criteria:

* Pregnant women and patients who do not meet the above criteria will be excluded.

Primary outcomes:
measure: The effectiveness and safety profile of procedural sedation using propofol versus midazolam/ketamine.
timeFrame: outcome measures will be monitored continuously and will be documented every few minutes from initiating sedation until the patient returns to his/her basic mental status
Secondary outcomes:
measure: The amnestic properties of procedural sedation with propofol versus midazolam/ketamine.
timeFrame: Recall issues will be assessed after the patient returns to his/her basic mental status and within 72 hours from the procedure (either on a follow up visit or by a phone call)
Other outcomes:
Locations:
city: Tel Aviv
country: Israel
facility: Tel Aviv Sourasky Medical Center
Study officials:
affiliation: Tel Aviv Sourasky Medical Center, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel
name: Pinchas Halpern, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04976998: Role of Ultrasonography in the Diagnosis of Carpal Tunnel Syndrome
Official title: Role of Ultrasonography in the Diagnosis of Carpal Tunnel Syndrome and Detection of Its Severity
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Carpal Tunnel Syndrome
Lead sponsor: Sohag University
Sponsor class: OTHER
First posted: 2021-07-26
Enrollment: 60
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: sohag university hospital patients and attendants

Brief summary: This prospective study aims to evaluate the median nerve in Carpal Tunnel Syndrome by high-frequency ultrasound and color Doppler in comparison with clinical and Nerve conduction studies.

Detailed description: This prospective study aims to evaluate the median nerve anatomical changes in Carpal Tunnel Syndrome by high-frequency ultrasound and color Doppler in comparison with clinical and Nerve conduction studies physiological changes to determine the efficacy of ultrasound to diagnose and determine the severity of carpal tunnel syndrome.

Eligibility criteria: Inclusion Criteria:

* Any Age Group with symptoms, clinical signs and NCS consistent with CTS

Exclusion Criteria:

* Uncooperative Patients .
* Patients with History of previous wrist surgery, fracture or traumatic nerve injury

Primary outcomes:
measure: anatomical changes in the median nerve in carpal tunnel syndrome
timeFrame: imaging within 24 hours from the nerve conduction studies and clinical assessment of the patient
Secondary outcomes:
Other outcomes:
Locations:
city: Sohag
country: Egypt
facility: Sohag University - Faculty of Medicine
Study officials:
affiliation: Sohag University
name: mostafa mm mohamed, MBBCH
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06367998: Effect of Pregabalin on Shoulder Pain in Patients With Central Sensitization After Arthroscopic Rotator Cuff Repair
Official title: The Effect of Pregabalin on Shoulder Pain of Patients With Myofascial Pain Syndrome and Central Sensitization Who Undergo Arthroscopic Rotator Cuff Repair
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: PHASE4
Conditions: Rotator Cuff Tears
Central Sensitisation
Neuropathic Pain
Lead sponsor: The Catholic University of Korea
Sponsor class: OTHER
Collaborators: name: Viatris Korea
First posted: 2024-04-16
Enrollment: 76
Sex: ALL
Minimum age (years): 20
Maximum age (years): 69
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: This study aims to investigate the effects of Pregabalin intake on shoulder pain management in patients with central sensitization undergoing arthroscopic rotator cuff repair. Although Pregabalin is known to be effective in controlling pain after shoulder arthroscopy, research on its efficacy in pain management for patients with central sensitization is scarce. Utilizing a list that identifies central sensitization, this study will explore whether Pregabalin can reduce postoperative pain in these patients and potentially improve joint mobility, emotional, and physical functioning. A prospective randomized study is planned, with inclusion criteria set for patients aged between 19 and 70 who have undergone arthroscopic rotator cuff repair.

The study will compare clinical outcomes up to one year postoperatively between two groups of 38 patients each. The case group will receive standard postoperative medications (NSAIDs) plus Pregabalin oral intake from the day before surgery to six weeks postoperatively, while the control group will receive only the standard postoperative medications without Pregabalin.


Eligibility criteria: Inclusion Criteria:

* Age over 19 to under 70
* Underwent arthroscopic rotator cuff repair due to a tear of the rotator cuff.
* Clinical diagnosis of myofascial pain syndrome
* Central sensitization (Central Sensitization Inventory (CSI) score of 40 or above).

Exclusion Criteria:

* Previous history of Pregabalin prescription
* Hypersensitivity reactions or severe complications after taking Pregabalin.
* Diagnosed with and are being treated for psychiatric disorders
* Localized infection, sepsis, or previous neurological abnormalities
* Uncontrolled hypertension (evidenced by a resting blood pressure of more than 100 mmHg)
* Liver function abnormalities (aspartate aminotransferase or alanine aminotransferase \&gt;60 IU/litre).
* major cardiovascular diseases or renal impairments

Primary outcomes:
measure: The Visual Analogue Scale (VAS) pain score
timeFrame: Preoperative, postoperative 2, 6 weeks, 2, 4, 6 and 12 months
Secondary outcomes:
measure: Constant shoulder score
timeFrame: Preoperative, postoperative 6 months and 12 months
measure: American shouler and elbow surgeons (ASES) score
timeFrame: Preoperative, postoperative 6 months and 12 months
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT06244498: Tranexamic Acid After Pathological Fracture Treated With Modular Arthroplasty
Official title: Tranexamic Acid After Pathological Fracture Treated With Modular Arthroplasty: Retrospective Observational Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Metastases to Bone
Keywords: Blood Transfusion
Neoplasm Metastasis
Bone
Lead sponsor: Podkarpackie Oncological Center
Sponsor class: OTHER
First posted: 2024-02-06
Enrollment: 110
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Investigetor analysed a group of paticipants who underwent surgery for metastatic tumours of the proximal femur using modular prostheses between 2017 and 2021.

Brief summary: This study assesses the safety and efficacy of TXA for patients treated for pathological femur fractures using modular prosthetics.

Detailed description: Tranexamic acid is an efficacious medication for curtailing blood loss, haemoglobin drop, and the requirement for transfusions. Additionally, it is a secure medication, even when administered to oncology patients receiving reduction haemarthroplasty for pathological femoral fractures.

Eligibility criteria: Inclusion Criteria:

* Patological fracture
* Arthroplasty using a modular prosthesis.

Exclusion Criteria:

* threatened fracture
* intraoperative blood transfusion
* fracture fixation

Primary outcomes:
measure: Number of participants who require a blood transfusion.
timeFrame: During Hospitalization (up to day 10)
Secondary outcomes:
measure: Estimeted blood lost after surgery.
timeFrame: During Hospitalization (up to day 3)
measure: Number of participants with embolic complication.
timeFrame: During Hospitalization (up to day 10)
Other outcomes:
Locations:
city: Brzozów
country: Poland
facility: SzSPOO Brzozów
state: Podkarpackie
Study officials:
References:
citation: CRASH-2 collaborators; Roberts I, Shakur H, Afolabi A, Brohi K, Coats T, Dewan Y, Gando S, Guyatt G, Hunt BJ, Morales C, Perel P, Prieto-Merino D, Woolley T. The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. Lancet. 2011 Mar 26;377(9771):1096-101, 1101.e1-2. doi: 10.1016/S0140-6736(11)60278-X.
Clinical trial NCT05747898: Cannula-based Versus Needle-based Subcision for Posttraumatic Atrophic Facial Scars
Official title: Cannula-based Versus Common Needle-based Subcision in the Treatment of Posttraumatic Atrophic Facial Scars: A Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Scar; Atrophy
Lead sponsor: Sohag University
Sponsor class: OTHER
First posted: 2023-02-28
Enrollment: 50
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Each scar was split into two equal halves; the upper right half were treated using a cannula- based subcision approach, while the lower left half was treated using a common needle-based procedure
Primary purpose: TREATMENT

Brief summary: This study aims to evaluate the effectiveness of cannula- based subcision versus common needle subcision in treatment of posttraumatic atrophic facial scars

Detailed description: In addition to cosmetic issues, atrophic scars can lead to psychological issues like social isolation, low self-esteem, and embarrassment. Subcision (Subcutaneous incision-less surgery) has been used for years to treat a variety of skin depressions, including atrophic acne scars and other depressed scars. Numerous modifications have been made throughout time to this surgical method to make it easier and more efficient. Although needle subcision is a straightforward, simple, useful, and practical procedure, it has many side effects and the overall success in this procedure is mild to moderate. So, in this study we evaluated the effectiveness of cannula- based subcision versus common needle subcision in treatment of posttraumatic atrophic facial scars.

Eligibility criteria: Inclusion Criteria:

* Adult Patients (\> 20-years old) with posttraumatic facial scar

Exclusion Criteria:

* other types of scars (e.g; postacne scars), pregnancy, lactation, bleeding or coagulation disorders, liability for keloid formation, history of kobnerization, and patients with systemic diseases (cardiac, chronic renal diseases, chronic liver diseases, asthma and hypertension) at the time of recruitment.

Primary outcomes:
measure: Vancouver scar scale (VSS)
timeFrame: 4 months
Secondary outcomes:
Other outcomes:
Locations:
city: Sohag
country: Egypt
facility: Sohag University
Study officials:
affiliation: Sohag University
name: Marwa Mohamed, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03312998: Incidence of Metal Failure During First Year Following Transpedicular Screws Fixation of Dorsolumbar Spine Fracture
Official title: Incidence of Metal Failure During First Year Following Transpedicular Screws Fixation of Dorso Lumbar Spine Fracture
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: SPINAL Fracture
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2017-10-18
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Recording incidence of metal failure in transpedicular screws fixation of dorsal umbra spine fracture during first year follow up


Eligibility criteria: Inclusion Criteria:

* Adult patients
* post traumatic dorsolumbar spine fracture fixed with short or long segment transpedicular screws
* With or without decompression

Exclusion Criteria:

* pediatric patients
* Pathological fractures

Primary outcomes:
measure: radiological assessment of transpedicular screws after dorsolumbar fixation
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Riaz-ur-Rehman, Azmatullah, Azam F, Mushtaq, Shah M. Treatment of traumatic unstable thoracolumbar junction fractures with transpedicular screw fixation. J Pak Med Assoc. 2011 Oct;61(10):1005-8.
citation: Wang L, Yan J, Li Y, Xu K, Li S, Tang P, Li H. The influence of hydroxypropyl-beta-cyclodextrin on the solubility, dissolution, cytotoxicity, and binding of riluzole with human serum albumin. J Pharm Biomed Anal. 2016 Jan 5;117:453-63. doi: 10.1016/j.jpba.2015.09.033. Epub 2015 Oct 9.
citation: Moon MS, Kim SS, Lee BJ, Moon JL, Lin JF, Moon YW. Radiographic assessment of congenital C2-3 synostosis. J Orthop Surg (Hong Kong). 2010 Aug;18(2):143-7. doi: 10.1177/230949901001800203.
citation: Moon MS, Choi WT, Sun DH, Chae JW, Ryu JS, Chang H, Lin JF. Instrumented ligamentotaxis and stabilization of compression and burst fractures of dorsolumbar and mid-lumbar spines. Indian J Orthop. 2007 Oct;41(4):346-53. doi: 10.4103/0019-5413.36999.