Clinical trial NCT04654871: Effects of Glucosamine and Chondroitin Sulfate Supplementation in Addition to Resistance Exercise Training and Manual Therapy in Patients With Knee Osteoarthritis
Official title: Effects of Glucosamine and Chondroitin Sulfate Supplementation in Addition to Resistance Exercise Training and Manual Therapy in Patients With Knee Osteoarthritis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Osteoarthritis
Osteoarthritis, Knee
Keywords: chondroitin sulfate
resistance exercise
strength training
manual therapy
glucosamine
joint mobilization
Lead sponsor: Foundation University Islamabad
Sponsor class: OTHER
First posted: 2020-12-04
Enrollment: 24
Sex: ALL
Minimum age (years): 40
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Osteoarthritis (OA) IS one of the most common joint disorders, affecting not only the joints but also the surrounding muscles, which become weak. Resistance exercise reduces pain and improves function in patients with OA of the knee. Nonsteroidal anti-inflammatory drugs (NSAIDs) are widely used by patients with OA to reduce pain and thereby maintain the ability to perform daily activities. However, there is accumulating evidence for a negative effect of NSAIDs, thus many patients with OA are treated with dietary supplementations such as glucosamine and chondroitin sulfate, and some studies show a beneficial effects on cartilage and pain. However, their effect on OA symptoms and cartilage remains controversial. Thus, it is important to investigate whether a potentially beneficial effect of glucosamine and chondroitin sulfate with resistance exercise and manual therapy in patients with knee OA.


Eligibility criteria: Inclusion Criteria:

* knee osteoarthritis for at least 3 months
* knee pain no more than 8/10
* Grade III or less on radiograph (Kellgren classification)

Exclusion Criteria:

* Malignancy
* Any additional Inflammatory disorders
* Infection
* Knee trauma
* lower limb fracture
* Lumbar radiculopathy or myelopathy
* knee surgery or replacement
* Intra-articular steroid therapy in the last 2 months

Primary outcomes:
measure: Visual Analogue Scale
timeFrame: 2 weeks
measure: Visual Analogue Scale
timeFrame: 4 weeks
measure: Knee Injury and Osteoarthritis Outcome Score
timeFrame: 2 weeks
measure: Knee Injury and Osteoarthritis Outcome Score
timeFrame: 4 weeks
measure: Knee Joint Range of Motion
timeFrame: 2 weeks
measure: Knee Joint Range of Motion
timeFrame: 4 weeks
measure: Body Composition
timeFrame: 2 weeks
measure: Body Composition
timeFrame: 4 weeks
measure: Fall risk
timeFrame: 2 weeks
measure: Fall risk
timeFrame: 4 weeks
measure: 5 repetition sit to stand test
timeFrame: 2 weeks
measure: 5 repetition sit to stand test
timeFrame: 4 weeks
measure: Modified sphygmomanometer dynamometry
timeFrame: 2 weeks
measure: Modified sphygmomanometer dynamometry
timeFrame: 4 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Islamabad
country: Pakistan
facility: Foundation University Institute of Rehabilitation Sciences.
state: Federal
Study officials:
References:
citation: Babur MN, Siddiqi FA, Tassadaq N, Arshad Tareen MA, Osama M. Effects of glucosamine and chondroitin sulfate supplementation in addition to resistance exercise training and manual therapy in patients with knee osteoarthritis: A randomized controlled trial. J Pak Med Assoc. 2022 Jul;72(7):1272-1277. doi: 10.47391/JPMA.2444.