louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03469128: Cognitive Processing Therapy vs. Sertraline for the Treatment of PTSD & SUD in Egyptian Patients
Official title: Cognitive Processing Therapy Versus Sertraline for the Treatment of Post-traumatic Stress Disorder & Substance Use Disorder Egyptian Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Psychologic Manipulation
Keywords: PTSD
CPT
SUD
Lead sponsor: British University In Egypt
Sponsor class: OTHER
First posted: 2018-03-19
Enrollment: 150
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Data were obtained by interviewing 587 patients diagnosed with SUD. Patients were interviewed by a clinician and asked to complete: Mini-International Neuropsychiatric Interview (M.I.N.I), and Clinician-Administered PTSD Scale (CAPS). Patients with comorbid SUD and PTSD were asked to complete: The Brief Addiction Monitor (BAM), PTSD Checklist-Civilian (PCL-5), Beck Depression Inventory (BDI-II), and Timeline Follow Back Interview (TLFB). Patients with comorbid SUD and PTSD were randomized to one of the following groups: 1) received CPT. 2) received Sertraline. 3) the Placebo control group.
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The present research was aimed at comparing the effects of Cognitive Processing Therapy (CPT) with the effects of Sertraline in treating patients who have dual diagnosis PTSD \& SUD. The present study examines the extent to which CPT is effective in treating PTSD symptoms for patients with PTSD and SUD.

Detailed description: Patients with co-occurrence PTSD \& SUD disorders were grouped into 3 groups: first: Cognitive Processing Therapy (CPT) in which participants completed 12 sessions of CPT. Second: were treated by Sertraline. Third: a placebo control group.

Eligibility criteria: Inclusion Criteria:

* Patients diagnosed with SUD

Exclusion Criteria:

* Patients diagnosed with other psychotic disorders

Primary outcomes:
measure: Questionnaire
timeFrame: 3 Months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: The British University in Egypt
name: Amani Elbarazi, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02126228: no Antibiotics for Elective Cesarean With Low Risk of Infection
Official title: A Randomized Controlled Trial on Antibiotics Application For Low Infection-risked Elective Cesarean
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Antibiotics , Elective Cesarean, China
Keywords: antibiotics, cesarean
Lead sponsor: Shandong University
Sponsor class: OTHER
First posted: 2014-04-29
Enrollment: 212
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: antibiotics group:202 none antibiotics group:212

Brief summary: The purpose of this study is to discuss whether the parturients who underwent elective cesarean of such kind do not need prophylactic use of antibiotics and evaluate the risks and economic benefits involved.


Eligibility criteria: Inclusion Criteria:

* Elective cesarean
* With normal temperature;
* No signs of infection;
* Normal degree of cleanliness in vaginal; .Normal amniotic fluid.

Exclusion Criteria:

* Failure of vaginal delivery and emergency cesarean;
* Premature rupture of membranes;
* Antibiotics having been applied to 3 days before cesarean;
* Having inflammation before cesarean: such as vaginitis, pelvic inflammatory disease, chorioamnionitis;
* Having infections in respiratory or urinary system before cesarean;
* Placenta previa or placental abruption;
* With medical and surgical complications;
* BMI ≥ 30kg/m2;
* Total blood loss more than 1000ml within 2 hours after cesarean

Primary outcomes:
measure: Temperature
timeFrame: 3days
Secondary outcomes:
measure: Postpartum hemorrhage volume estimates and Routine blood test.
timeFrame: 3days
Other outcomes:
measure: Observation of puerperal infection
timeFrame: 30days
Locations:
city: Jinan
country: China
facility: 2nd Hospital of Shandong University
state: Shandong
Study officials:
affiliation: Obstetrics of 2nd Hospital of Shandong University
name: YONGPING XU, MD.PhD
role: STUDY_DIRECTOR
References:
citation: Committee opinion no. 465: antimicrobial prophylaxis for cesarean delivery: timing of administration. Obstet Gynecol. 2010 Sep;116(3):791-792. doi: 10.1097/AOG.0b013e3181f68086.
Clinical trial NCT00407628: Neural Correlates of Lower Extremity Motor Recovery in Stroke Patients: Longitudinal Diffusion Spectrum Imaging Studies
Official title: Neural Correlates of Lower Extremity Motor Recovery in Stroke Patients: Longitudinal Diffusion Spectrum Imaging Studies
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Stroke
Keywords: Stroke
Diffusion spectrum tractography
Functional MRI (fMRI)
Lower extremity
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
Collaborators: name: National Science and Technology Council, Taiwan
First posted: 2006-12-05
Enrollment: 24
Sex: ALL
Minimum age (years): 30
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: stroke patients

Brief summary: To investigate the relationship between the integrity of the white matter, including the corticospinal tracts and the corpus callosum, with the recovery of lower extremity function in patients with cerebral stroke at the subacute and chronic stages.

Detailed description: Recent studies have provided strong evidence that motor recovery after adult ischemic stroke is a function of neural plasticity. Up to date, it remains largely unknown as to the relationship between the integrity of the subcortical white matter with the lower extremity function recovery. Given the fact that the white matter is more resistant to ischemia after acute stroke than the gray matter (Falcao et al., 2004) and that the intensity of white matter in stroke has been found to be much greater in many brain areas in stroke than in healthy controls (Wen et al., 2004), it is of interest to study how the integrity of the subcortical white matter, primarily the corticospinal tracts and the corpus callosum, contributes to the recovery of lower extremity function in subacute and chronic stroke with lesions involving different areas of the brain.

Eligibility criteria: Inclusion Criteria:

* between 30 to 80 years old
* diagnosis of the first-time onset of stroke as confirmed by imaging studies
* within 30 days post onset University Hospital
* brain lesions mainly involving either the cortical primary motor cortex (M1) area or confined to the subcortical (M1 spared)
* No neurological or orthopedic problems which would affect their lower extremity function
* no contraindications for MRI studies

Exclusion Criteria:

* medically unstable
* unable to communicate with the experimenters

Primary outcomes:
measure: clinical assessments, included balance, motor, walking,ADL, will be obtained for tests performed on D7, D30 and D90
timeFrame: D30, D90 and D180 post stroke onset
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: China
facility: School and Graduate Institute of Physical Therapy College of Medicine, National Taiwan University
state: Taiwan
Study officials:
affiliation: National Taiwan University Hospital
name: Pei-Fang Tang, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT04004728: Laser Treatment Of Leg Telangiectasias
Official title: Aavaliação do Tratamento de Telangiectasias Dos Membros Inferiores Com Laser 1064mm
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Leg Veins
Keywords: laser
telangiectasias
leg veins
sclerotherapy
Lead sponsor: University of Sao Paulo
Sponsor class: OTHER
First posted: 2019-07-02
Enrollment: 30
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: One leg laser ando the other sclerotherapy.
Primary purpose: TREATMENT

Brief summary: Is 1064 nm YAG Laser better than sclerotherapy to treat leg veins?

Detailed description: Comparison between laser and sclerotherapy in the treatment of telangiectasias of legs.

Eligibility criteria: Inclusion Criteria:

* patients with leg telangiectasias

Exclusion Criteria:

* varicose veins
* DVT
* pregnancy

Primary outcomes:
measure: Changes analysis after treatments of leg telangiectasias´clearance through photography using a scale of improvement.
timeFrame: Analysis of photographic changes previous, and one week after treatment. Patient reanalysis after 1 and 3 months
measure: Changes analysis after treatments of leg telangiectasias´clearance using a questionnaire to classify the pain
timeFrame: 1 week after treatment
measure: Changes analysis after treatments of leg telangiectasias´clearance using a questionnaire to classify the cleaning of vessels
timeFrame: 1 week after treatment
measure: Changes analysis after treatments of leg telangiectasias´clearance using a questionnaire to classify the satisfaction with results
timeFrame: 1 week after treatment
Secondary outcomes:
Other outcomes:
Locations:
city: Sao Paulo
country: Brazil
facility: Vascular Surgery HCFMUSP
Study officials:
affiliation: Hospital das Clinicas, University of Sao Paulo
name: Nelson Wolosker, MD, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT06438328: Effectiveness of Scapular Muscle Training in Improving Grip Strength Among Lateral Epicondylitis Patients
Official title: Effectiveness of Scapular Muscle Training in Improving Grip Strength Among Lateral Epicondylitis Patients
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Lateral Epicondylitis
Lead sponsor: Superior University
Sponsor class: OTHER
First posted: 2024-05-31
Enrollment: 56
Sex: ALL
Minimum age (years): 20
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The effectiveness of scapular muscular training along with conventional physiotherapy on the improving the grip strength of the patients suffering with the lateral epicondylitis was assessed by diving 56 patinets in two grousp as Group A (n=28) was treated with conventional physiotherapy treatment and Group B (n=28) was treated with Scapular strengthening and conventional physiotherapy protocol.


Eligibility criteria: Inclusion Criteria:

* Age: 20-50 years
* Gender: Male and Female
* Pain on the lateral epicondyle
* VAS scoring more than 4
* Positive test: Tomson test, Mill's test , Cozen;s sign and Maudsley's test

Exclusion Criteria:

* Any neurological/ Radiculopathy signs in upper limb
* Cervical pain
* Bilateral elbow pain
* History of elbow or wrist surgery
* Receiving any corticosteroid injection within last 6 months

Primary outcomes:
measure: Severity of Disability
timeFrame: 12 Months
measure: Grip strength:
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Bhakkar
country: Pakistan
facility: Fatima medical center near green town
state: Punjab
Study officials:
References:
Clinical trial NCT06154928: Effects of Warm Water on GI System in Laparoscopic Cholecystectomy Patients
Official title: Investigation of the Effect of Drinking Warm Water on the Gastrointestinal System Functions of Patients Undergoing Laparoscopic Cholecystectomy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Laparoscopic Cholecystectomy
Abdominal Distention
Keywords: Laparoscopic Cholecystectomy
Bowel Movements
Lead sponsor: Kilis 7 Aralik University
Sponsor class: OTHER
Collaborators: name: Hasan Kalyoncu University
First posted: 2023-12-04
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: This single-center randomized controlled study, conducted between January 15 and May 15, 2022, comprised 100 patients equally divided into the Water Group (WG) and Control Group (CG). Patients in the WG were allowed to take warm water orally during the 2nd postoperative hour without waiting for the onset of bowel sounds or flatus while those in the CG were not. GI functions were evaluated at 2, 4, 8, and 12 postoperative hours and the findings were recorded.
Primary purpose: SUPPORTIVE_CARE

Brief summary: Objective: The study was carried out to determine the effect of drinking warm water on GIS functions in patients who underwent laparoscopic cholecystectomy surgery.

Detailed description: Method: The research was completed in Kahramanmaraş Necip Fazıl City Hospital with 100 patients, 50 of whom were in the Study Group (WG) and 50 were in the Control Group (KG). The patients in CG were given warm water to drink at the 2nd hour after surgery. On the other hand, patients in KG were allowed to drink warm water after bowel sounds started and gas was produced. Patients in both groups were 2,4,8,12 after surgery. hours were evaluated in terms of GIS functions. Statistical analysis was done in SPSS 22.0 for Windows package program. A p\<0.05 value was accepted for statistical significance.

Eligibility criteria: Inclusion Criteria:

* over 18 years old
* having surgery

Exclusion Criteria:

* not meeting the sampling criteria
* Refused to participate Canceled surgery

Primary outcomes:
measure: Descriptive Information Form:
timeFrame: up to 18 weeks
Secondary outcomes:
measure: Postoperative Measurement and Evaluation Form:
timeFrame: up to 18 weeks
Other outcomes:
Locations:
city: Kahramanmaraş
country: Turkey
facility: Necip Fazıl Kısakürek Şehir Hastanesi
Study officials:
References:
Clinical trial NCT05455528: Preoperative Renal Insufficiency Predicts Postoperative Adverse Outcomes
Official title: Preoperative Renal Insufficiency Predicts Postoperative Adverse Outcomes: A Matched Cohort Study Using the NSQIP Database
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Renal Insufficiency
Morality
Lead sponsor: Taipei Medical University Hospital
Sponsor class: OTHER
First posted: 2022-07-13
Enrollment: 2421286
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: This study analyze surgical patient data from the American College of SurgeonsNational Surgical Quality Improvement Program (ACS-NSQIP) that was acquired between 2013 and 2018.

Brief summary: The main purpose of this study is to evaluate the risk of postoperative mortality and complications in surgical populations with preoperative renal insufficiency.

Detailed description: This retrospective cohort study use the National Surgical Quality Improvement Program (NSQIP) database to evaluate the risk of postoperative morbidity and mortality in the surgical population. Patients with estimated. glomerular filtration rate(GFR) \< 60 ml/min per 1.73 square meter are defined as the renal insufficiency group. Patients with estimated GFR \> 90 ml/min per 1.73 square meter are defined as patients without renal insufficiency. Propensity score-matching methods and multivariate logistic regression are used to calculate the risk of postoperative morbidity and mortality.

Eligibility criteria: Inclusion Criteria:

* Patients with estimated GFR \< 60 ml/min per 1.73 square meter or currently on dialysis are included in renal insufficiency group.
* Patients with estimated GFR \> 90 ml/min per 1.73 square meter are included in non-renal insufficiency group

Exclusion Criteria:

* Patients population with estimated GFR between 60-90 is not included in the study

Primary outcomes:
measure: Risk of postoperative mortality
timeFrame: 30 days after surgery date
Secondary outcomes:
measure: Risk of postoperative morbidities
timeFrame: 30 days after surgery date
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Taipei Medical University Hospital
state: Taiwan ( R.o.c.)
Study officials:
affiliation: Department of Anesthesiology, Taipei Medical University Hospital, 252 Wuxing St., Taipei 110 Taiwan
name: Chao-Shun Lin, MD, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT06508528: Intervention of Growth Mindset for Intern Nursing Students
Official title: A 12-week Growth Mindset Intervention for Intern Nursing Students
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Growth, Psychological
Lead sponsor: Huzhou University
Sponsor class: OTHER
Collaborators: name: Hangzhou Normal University
name: The Affiliated Hospital of Hangzhou Normal University
First posted: 2024-07-18
Enrollment: 64
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This is a 12-week growth mindset intervention for the nursing students during clinical rotation practice. It aims at promoting the core self-evaluation and professional self-efficacy for them.

Detailed description: 64 intern nursing students from a hospital in China were recruited for this study and randomly assigned to the intervention group and control group.

Eligibility criteria: Inclusion Criteria:

* full-time intern nursing students including Junior college and undergraduate students；
* require a clinical nursing internship for at least 8 months ；
* know the purpose of the study and volunteer to participate in the study.

Exclusion Criteria:

* recently experienced significant stress events such as accidental injuries, nursing accidents, etc；
* receiving other training that may affect this intervention.

Primary outcomes:
measure: growth mindset
timeFrame: We will measure the score of growth mindset before the training, 6 weeks of training, and 12 weeks of training.
measure: core self-evaluation
timeFrame: We will measure the score of core self-evaluation before the training, 6 weeks of training, and 12 weeks of training.
measure: professional self-efficacy
timeFrame: We will measure the score of professional self-efficacy before the training, 6 weeks of training, and 12 weeks of training.
Secondary outcomes:
Other outcomes:
Locations:
city: Hangzhou
country: China
facility: Hangzhou Normal University
Study officials:
affiliation: Huzhou University
name: MeiJuan Cao, Dr.
role: STUDY_DIRECTOR
References:
Clinical trial NCT00393328: Bioequivalence Study of Atazanavir 300 mg Capsule
Official title: Bioequivalence Study of Atazanavir Single 300 mg Capsule Relative to Two Atazanavir 150 mg Capsules in Healthy Subjects
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: HIV Infections
Lead sponsor: Bristol-Myers Squibb
Sponsor class: INDUSTRY
First posted: 2006-10-27
Enrollment: 46
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER

Brief summary: The purpose of this clinical research study is to assess the bioequivalence of atazanavir administered as a single 300 mg capsule relative to two atazanavir 150 mg capsules in healthy subjects.


Eligibility criteria: Inclusion Criteria:

* Healthy male and female subjects between the ages of 18 to 50 years old with a body mass index (BMI) of 18 to 30 kg/m²
* Prior to enrollment, subjects must have physical and laboratory test findings within normal limits, and women of childbearing potential (WOCBP) must have a negative pregnancy test.

Primary outcomes:
measure: Blood atazanavir pharmacokinetic sampling to be collected on days 1, 2 and 3 of each of the 2 periods of the study
Secondary outcomes:
measure: Blood ritonavir pharmacokinetic sampling to be collected on days 1, 2 and 3 of each of the 2 periods of the study
measure: Safety parameters including physical exam (PE), vital signs (VS), electrocardiogram (ECG) and clinical laboratory tests will be collected at study discharge
Other outcomes:
Locations:
city: Hamilton
country: United States
facility: Local Institution
state: New Jersey
Study officials:
affiliation: Bristol-Myers Squibb
name: Bristol-Myers Squibb
role: STUDY_DIRECTOR
References:
Clinical trial NCT00164528: Intervening With Children/Adolescents With FAS/ARND
Official title: Intervening With Children/Adolescents With FAS/ARND
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
PHASE2
Conditions: Treatment
Control
Lead sponsor: Centers for Disease Control and Prevention
Sponsor class: FED
Collaborators: name: University of Washington
First posted: 2005-09-14
Enrollment: 52
Sex: ALL
Minimum age (years): 5
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: ECT

Brief summary: Children diagnosed through the FAS DPN clinic (who receive non-study services through the clinic/referrals) will receive baseline assessment. The baseline assessment for the child will include: medical issues (including medication), intellectual assessment, academic achievement, language, social functioning, executive functioning, neurological assessment, perceived self-confidence, and behavioral observation of parent-child interactions (videotaped and coded). For caregivers, baseline assessment will include: demographics, medical histories, educational history, current services, satisfaction with services, knowledge of FAS, stress, parenting competence, and family functioning.

Detailed description: Functional analysis of challenging behaviors will be conducted. Intervention will be an individualized, multimodal, behavioral consultation. The consultation will include: FAS education, emotional/practical support, and teaching child management strategies specific to children with FAS/ARND, advocacy assistance, and school consultation. Specific procedure will be based on previous findings and experience. In particular, specialized "Behavior Support Plans" will be developed for each child with input from parents, teachers, and clinicians.

Team consultations at the child's home during weekly visits. Instruction will include information on FAS, behavioral strategies, and information for advocating with service systems.

Evaluation Plan: Both interventions: Treatment and control groups will be compared using pre- and post-tests measures. Post-tests will be at the conclusion of the intervention and at a 9-month follow-up (end of school year).

Eligibility criteria: Inclusion Criteria:

* children 5 to 12 years of age

Exclusion Criteria:

-

Primary outcomes:
measure: behavior
Secondary outcomes:
Other outcomes:
Locations:
city: Seattle
country: United States
facility: University of Washington
state: Washington
Study officials:
affiliation: University of Washington
name: Susan Astley, PhD
role: PRINCIPAL_INVESTIGATOR
References: