Clinical trial NCT05815498: A Study of mRNA-1283 Injection Compared With mRNA-1273 Injection in Participants ≥12 Years of Age to Prevent COVID-19
Official title: A Randomized, Observer-Blind, Active-Controlled Phase 3 Study to Investigate the Safety, Immunogenicity, and Relative Vaccine Efficacy of mRNA-1283 Compared With mRNA-1273 in Participants Aged ≥12 Years for the Prevention of COVID-19
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: COVID-19
Keywords: mRNA-1283.222
mRNA-1273.222
mRNA-1283.815
mRNA-1273.815
SARS-CoV-2
SARS-CoV-2 Vaccine
Coronavirus
Virus Diseases
Messenger RNA
COVID-19
COVID-19 Vaccine
Moderna
Lead sponsor: ModernaTX, Inc.
Sponsor class: INDUSTRY
First posted: 2023-04-18
Enrollment: 14246
Sex: ALL
Minimum age (years): 12
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this study (Part 1 and Part 2) is to evaluate the relative vaccine efficacy (rVE), safety, reactogenicity, and immunogenicity of mRNA-1283.222 versus mRNA-1273.222 (Part 1) and mRNA-1283.815 versus mRNA-1273.815 (Part 2).


Eligibility criteria: Key Inclusion Criteria:

* Investigator's assessment that the participant understands and is willing and physically able to comply with protocol-mandated follow-up, including all procedures.
* For female participants of childbearing potential: negative pregnancy test, adequate contraception or has abstained from all activities that could result in pregnancy for at least 28 days prior to the first injection, and agreement to continue adequate contraception or abstinence through 90 days following the vaccine administration.
* Part 1: Has previously received a primary series of an authorized/approved COVID-19 vaccine. For participants ≥18 years of age, at least 1 booster dose must have also been received. Proof of prior vaccination is required. A heterologous vaccine regimen is acceptable.

Part 2: No prior vaccination is required. For participants who have been previously vaccinated, proof of vaccination is required.

Key Exclusion Criteria:

* Has had close contact, as defined by the Centers for Disease Control and Prevention (CDC), with someone who had a SARS-CoV-2 infection in the past 14 days, or COVID-19 in the past 10 days.
* Participant is acutely ill or febrile (temperature ≥38.0 degrees Celsius \[°C\]/100.4 degrees Fahrenheit \[°F\]) 72 hours prior to or at the Screening Visit or Day 1.
* Any medical, psychiatric, or occupational condition, including reported history of substance abuse, that, in the opinion of the investigator, might pose additional risk due to participation in the study or could interfere with the interpretation of study results.
* Has received systemic immunosuppressants or immune-modifying drugs for \>14 days in total within 181 days prior to Screening (for corticosteroids ≥10 milligrams (mg)/day of prednisone equivalent) or is anticipating the need for immunosuppressive treatment at any time during participation in the study.
* Has received or plans to receive any licensed vaccine ≤60 days prior to the study injection (Day 1) or plans to receive a licensed vaccine within 60 days after the study injection.
* Has received systemic immunoglobulins or blood products within 90 days prior to the Screening Visit or plans to receive during the study.
* Has donated ≥450 milliliters (mL) of blood products within 28 days prior to the Screening Visit or plans to donate blood products during the study.
* Has participated in an interventional clinical study within 28 days prior to the Screening Visit based on the medical history interview or plans to do so while participating in this study.

Note: Other inclusion and exclusion criteria may apply.

Primary outcomes:
measure: Part 1: Geometric Mean Ratio (GMR) of Omicron BA.4/5 mRNA-1283.222 Over the Omicron BA.4/5 mRNA-1273.222
timeFrame: Day 29
measure: Part 1: Seroresponse Rate (SRR) Difference of Omicron BA.4/5 Between mRNA-1283.222 and mRNA-1273.222
timeFrame: Day 29
measure: Part 1: GMR of the Ancestral Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) D614G mRNA-1283.222 Over the Ancestral SARS-CoV-2 D614G mRNA-1273.222
timeFrame: Day 29
measure: Part 1: SRR Difference of Ancestral SARS-CoV-2 D641G Between mRNA-1283.222 and mRNA-1273.222
timeFrame: Day 29
measure: Parts 1 and 2: rVE of mRNA-1283 and mRNA-1273 (Variant Formulations) to Prevent the First Event of COVID-19
timeFrame: From 14 days after injection to Day 365
measure: Part 1: Number of Participants with Solicited Local and Systemic Reactogenicity Adverse Reactions (ARs)
timeFrame: Up to Day 7 (7-day follow-up after vaccination)
measure: Part 2: Number of Participants with Solicited Local and Systemic Reactogenicity ARs in Adolescents and Previously Unvaccinated Participants
timeFrame: Up to Day 7 (7-day follow-up after vaccination)
measure: Parts 1 and 2: Number of Participants with Unsolicited Adverse Events (AEs)
timeFrame: Up to Day 28 (28-day follow-up after vaccination)
measure: Parts 1 and 2: Number of Participants with Any Serious AEs (SAEs), Medically Attended AEs (MAAEs), AEs Leading to Withdrawal From Study, and AEs of Special Interest (AESIs)
timeFrame: Day 1 to end of study (EOS) (Day 365)
Secondary outcomes:
measure: Part 1: Geometric Mean Titers (GMTs) of Omicron BA.4/5 and Ancestral SARS-CoV-2 D614G
timeFrame: Days 91, 181, and 365
measure: Part 1: SRR Against Omicron BA.4/5 and Ancestral SARS-CoV-2 D614G
timeFrame: Days 29, 91, 181, and 365
measure: Parts 1 and 2: Number of Participants with a SARS-CoV-2 Infection (Symptomatic or Asymptomatic)
timeFrame: From 14 days after injection to Day 365
measure: Part 2: Number of Participants with Severe COVID-19
timeFrame: From 14 days after injection to Day 365
Other outcomes:
Locations:
city: Huntsville
country: United States
facility: Optimal Research
state: Alabama
city: Vestavia Hills
country: United States
facility: Accel Research Sites- Achieve Clinical Research
state: Alabama
city: Chandler
country: United States
facility: Chandler Clinical Trials
state: Arizona
city: Phoenix
country: United States
facility: Phoenix Clinical Research LLC
state: Arizona
city: Phoenix
country: United States
facility: FRC - CCT Research
state: Arizona
city: Scottsdale
country: United States
facility: Headlands Research Sarasota
state: Arizona
city: Tempe
country: United States
facility: Clinical Research Consortium
state: Arizona
city: Tucson
country: United States
facility: Noble Clinical Research, LLC
state: Arizona
city: Tucson
country: United States
facility: Del Sol research Management LLC.
state: Arizona
city: Little Rock
country: United States
facility: Lynn Institute of the Ozarks
state: Arkansas
city: Anaheim
country: United States
facility: Anaheim Clinical Trials, LLC
state: California
city: Banning
country: United States
facility: Velocity Clinical Research, Banning
state: California
city: Chula Vista
country: United States
facility: Velocity Clinical Research- Chula Vista
state: California
city: Colton
country: United States
facility: Benchmark Research
state: California
city: Huntington Beach
country: United States
facility: Marvel Clinical Research 002, LLC
state: California
city: Huntington Park
country: United States
facility: Velocity Clinical Research Huntington Park
state: California
city: La Mesa
country: United States
facility: Velocity Clinical Research
state: California
city: Lancaster
country: United States
facility: Chemidox Clinical Trials
state: California
city: Long Beach
country: United States
facility: Long Beach Clinical Trials
state: California
city: Los Angeles
country: United States
facility: Velocity Clinical Research- Westlake
state: California
city: North Hollywood
country: United States
facility: Velocity Clinical Research-North Hollywood
state: California
city: Pomona
country: United States
facility: Empire Clinical Research
state: California
city: Riverside
country: United States
facility: CenExel - CITrials
state: California
city: Riverside
country: United States
facility: Artemis Institute for Clinical Research
state: California
city: Rolling Hills Estates
country: United States
facility: Peninsula Research Associates
state: California
city: Sacramento
country: United States
facility: Benchmark Research
state: California
city: San Diego
country: United States
facility: Artemis Institute for Clinical Research
state: California
city: San Diego
country: United States
facility: Acclaim Clinical Research
state: California
city: Aurora
country: United States
facility: Lynn Institute of Denver
state: Colorado
city: Denver
country: United States
facility: Velocity Clinical Research Denver
state: Colorado
city: Fort Collins
country: United States
facility: Tekton Research - Fort Collins
state: Colorado
city: Longmont
country: United States
facility: Tekton Research, Inc- Longmont Center
state: Colorado
city: Coral Gables
country: United States
facility: Alliance for Multispeciality Research - Miami
state: Florida
city: Crystal River
country: United States
facility: Nature Coast Clinical Research
state: Florida
city: Cutler Bay
country: United States
facility: Beautiful Minds Clinical Research Center
state: Florida
city: DeLand
country: United States
facility: Clinical Research Partners LLC
state: Florida
city: DeLand
country: United States
facility: Hillcrest Medical Research, LLC
state: Florida
city: Hallandale Beach
country: United States
facility: Velocity Clinical Research, Hallandale Beach
state: Florida
city: Hialeah
country: United States
facility: Sweet Hope Research Specialty, Inc.
state: Florida
city: Hollywood
country: United States
facility: CenExel Research Centers of America
state: Florida
city: Inverness
country: United States
facility: Nature Coast Clinical Research
state: Florida
city: Jacksonville
country: United States
facility: Encore Research Group-Jacksonville Center for Clinical Research
state: Florida
city: Jacksonville
country: United States
facility: Clinical Neuroscience Solutions, Inc
state: Florida
city: Jupiter
country: United States
facility: Health Awareness INC
state: Florida
city: Lakeland
country: United States
facility: Accel Clinical Research
state: Florida
city: Largo
country: United States
facility: Accel Research Sites
state: Florida
city: Maitland
country: United States
facility: Acclaim Clinical Research
state: Florida
city: Miami Lakes
country: United States
facility: Floridian Clinical Research
state: Florida
city: Miami Lakes
country: United States
facility: Global Health Research Center, Inc.
state: Florida
city: Miami
country: United States
facility: Suncoast Research Group, LLC
state: Florida
city: Miami
country: United States
facility: Clinical Trials of Florida
state: Florida
city: Miami
country: United States
facility: Suncoast Research Associates, LLC
state: Florida
city: Orlando
country: United States
facility: Clinical Neuroscience Solutions (CNS Healthcare site)
state: Florida
city: Orlando
country: United States
facility: Headlands Research Orlando
state: Florida
city: Palmetto Bay
country: United States
facility: Innovation Medical Research Center
state: Florida
city: Pembroke Pines
country: United States
facility: Pines Care Research Center, Inc.
state: Florida
city: Pembroke Pines
country: United States
facility: Suncoast Research Associates, LLC
state: Florida
city: Pinellas Park
country: United States
facility: Synexus
state: Florida
city: Sunrise
country: United States
facility: Precision Clinical Research
state: Florida
city: Tampa
country: United States
facility: Global Health Research Center, Inc.
state: Florida
city: Tampa
country: United States
facility: Santos Research Center CORP
state: Florida
city: West Palm Beach
country: United States
facility: Palm Beach Research Center
state: Florida
city: Atlanta
country: United States
facility: Delricht Research
state: Georgia
city: Atlanta
country: United States
facility: Atlanta Clinical Research Center
state: Georgia
city: Chamblee
country: United States
facility: Baybol Research Institute
state: Georgia
city: Columbus
country: United States
facility: Centricity Research
state: Georgia
city: Decatur
country: United States
facility: Elite Research Network
state: Georgia
city: Eatonton
country: United States
facility: Accel Research Sites Lake Oconee
state: Georgia
city: Norcross
country: United States
facility: Georgia Clinic, PC/CCT Research
state: Georgia
city: Stockbridge
country: United States
facility: Clinical Research Atlanta/Headlands
state: Georgia
city: Meridian
country: United States
facility: Velocity Clinical Research
state: Idaho
city: Chicago
country: United States
facility: Chicago Clinical Research Institute
state: Illinois
city: Chicago
country: United States
facility: Great Lakes Clinical Trials
state: Illinois
city: Valparaiso
country: United States
facility: Velocity Clinical Research Valparaiso
state: Indiana
city: El Dorado
country: United States
facility: Alliance for Multispecialty Research, LLC
state: Kansas
city: Lenexa
country: United States
facility: Johnson County Clin-Trials, Inc (JCCT)
state: Kansas
city: Wichita
country: United States
facility: Alliance for Multispecialty Research, LLC- Wichita
state: Kansas
city: Wichita
country: United States
facility: Tekton Research Inc
state: Kansas
city: Lexington
country: United States
facility: Alliance for Multispecialty Research-Lexington
state: Kentucky
city: Versailles
country: United States
facility: Versailles Family Medicine
state: Kentucky
city: Baton Rouge
country: United States
facility: Meridian Clinical Research
state: Louisiana
city: Covington
country: United States
facility: Benchmark Research
state: Louisiana
city: Covington
country: United States
facility: MedPharmics
state: Louisiana
city: Metairie
country: United States
facility: Benchmark Research
state: Louisiana
city: New Orleans
country: United States
facility: Delricht Research
state: Louisiana
city: Prairieville
country: United States
facility: Delricht Clinical Research
state: Louisiana
city: Eldridge
country: United States
facility: Centennial Medical Group
state: Maryland
city: Boston
country: United States
facility: Brigham and Women's Hospital
state: Massachusetts
city: Brookline
country: United States
facility: DM Clinical Research
state: Massachusetts
city: Southfield
country: United States
facility: Great Lakes Research Institute
state: Michigan
city: Minneapolis
country: United States
facility: Clinical Research Institute
state: Minnesota
city: Gulfport
country: United States
facility: Delricht Research
state: Mississippi
city: Kansas City
country: United States
facility: The Center for Pharmaceutical Research
state: Missouri
city: Saint Louis
country: United States
facility: Sundance Clinical Research, LLC
state: Missouri
city: Springfield
country: United States
facility: Delricht Research
state: Missouri
city: Town And Country
country: United States
facility: Delricht Research
state: Missouri
city: Missoula
country: United States
facility: Montana Medical Research, Inc
state: Montana
city: Fremont
country: United States
facility: CCT research/ Methodist Physicians Clinic- Prairie Fields
state: Nebraska
city: Grand Island
country: United States
facility: Velocity Clinical Research
state: Nebraska
city: Lincoln
country: United States
facility: Meridian Clinical Research, LLC
state: Nebraska
city: Omaha
country: United States
facility: Velocity Clinical Research
state: Nebraska
city: Papillion
country: United States
facility: Papillon Research Centre
state: Nebraska
city: Las Vegas
country: United States
facility: Wr-Crcn, Llc
state: Nevada
city: North Las Vegas
country: United States
facility: Las Vegas Clinical Trials
state: Nevada
city: Warren
country: United States
facility: IMA Clinical Research
state: New Jersey
city: Albuquerque
country: United States
facility: Velocity Clinical Research- New Mexico
state: New Mexico
city: Albuquerque
country: United States
facility: IMA Clinical Research
state: New Mexico
city: East Syracuse
country: United States
facility: Velocity Clinical Research, Syracuse
state: New York
city: New York
country: United States
facility: IMA Clinical Research
state: New York
city: Rochester
country: United States
facility: Rochester Clinical Research, Inc.
state: New York
city: Monroe
country: United States
facility: Monroe Biomedical Research
state: North Carolina
city: Wilmington
country: United States
facility: Trial Management Associates, LLC
state: North Carolina
city: Cincinnati
country: United States
facility: CTI Clinical Research Center
state: Ohio
city: Cincinnati
country: United States
facility: Velocity Clinical Research, Inc
state: Ohio
city: Cincinnati
country: United States
facility: Velocity Clinical Research
state: Ohio
city: Cincinnati
country: United States
facility: Velocity Clinical Research - Cincinnati
state: Ohio
city: Cleveland
country: United States
facility: Velocity Clinical Research
state: Ohio
city: Edmond
country: United States
facility: Tekton Research- Edmond
state: Oklahoma
city: Moore
country: United States
facility: Tekton Research Inc
state: Oklahoma
city: Tulsa
country: United States
facility: Delricht Research
state: Oklahoma
city: Yukon
country: United States
facility: Tekton Research- Yukon
state: Oklahoma
city: Medford
country: United States
facility: Velocity Clinical Research, Medford
state: Oregon
city: Portland
country: United States
facility: Summit Research Headlands LLC
state: Oregon
city: Philadelphia
country: United States
facility: DM Clinical Research
state: Pennsylvania
city: Anderson
country: United States
facility: Synexus Clinical Research US, Inc
state: South Carolina
city: Anderson
country: United States
facility: Velocity Clinical Research-Anderson
state: South Carolina
city: Charleston
country: United States
facility: Delricht Research
state: South Carolina
city: Columbia
country: United States
facility: Velocity Clinical Research
state: South Carolina
city: Greenville
country: United States
facility: Velocity Clinical Research, Greenville
state: South Carolina
city: Myrtle Beach
country: United States
facility: Carolina Health Specialists
state: South Carolina
city: North Charleston
country: United States
facility: Coastal Carolina Research Center
state: South Carolina
city: Spartanburg
country: United States
facility: Spartanburg Medical Research
state: South Carolina
city: Spartanburg
country: United States
facility: Velocity Clinical Research- Spartanburg
state: South Carolina
city: Hendersonville
country: United States
facility: Delricht Research
state: Tennessee
city: Nashville
country: United States
facility: Clinical Research Associates, Inc.
state: Tennessee
city: Austin
country: United States
facility: Benchmark Research
state: Texas
city: Austin
country: United States
facility: Tekton Research Inc
state: Texas
city: Beaumont
country: United States
facility: Tekton Research - Beaumont
state: Texas
city: Brownsville
country: United States
facility: PanAmerican Clinical Research, LLC
state: Texas
city: Brownsville
country: United States
facility: Headlands Research Brownsville
state: Texas
city: Dallas
country: United States
facility: Zenos Clinical Research
state: Texas
city: Fort Worth
country: United States
facility: Ventavia Research Group
state: Texas
city: Fort Worth
country: United States
facility: Benchmark Research
state: Texas
city: Houston
country: United States
facility: DM Clinical Research
state: Texas
city: Houston
country: United States
facility: DM Clinical Research
state: Texas
city: Keller
country: United States
facility: Ventavia Research Group
state: Texas
city: McKinney
country: United States
facility: DELRICHT RESEARCH at ZOMNIR FAMILY MEDICINE
state: Texas
city: Plano
country: United States
facility: Research Your Health
state: Texas
city: Round Rock
country: United States
facility: Be Well Clinical Studies
state: Texas
city: San Antonio
country: United States
facility: Clinical Trials of Texas, Inc.
state: Texas
city: San Antonio
country: United States
facility: Diagnostics Research Group
state: Texas
city: San Antonio
country: United States
facility: Tekton Research -San Antonio
state: Texas
city: Sugar Land
country: United States
facility: DM Clinical Research
state: Texas
city: Tomball
country: United States
facility: DM Clinical Research
state: Texas
city: Bountiful
country: United States
facility: Cope Family Medicine
state: Utah
city: Pleasant View
country: United States
facility: Mountain View Ogden Clinic/CCT Research
state: Utah
city: Salt Lake City
country: United States
facility: JBR Clinical Research
state: Utah
city: Salt Lake City
country: United States
facility: J. Lewis Research, Inc. / Foothill Family Clinic South
state: Utah
city: Newport News
country: United States
facility: Health Research of Hampton Roads, Inc.
state: Virginia
city: Portsmouth
country: United States
facility: Velocity Clinical Research
state: Virginia
city: Richmond
country: United States
facility: Clinical Research Partners, LLC
state: Virginia
city: Hamilton
country: Canada
facility: Hamilton Medical Research group
state: Ontario
city: London
country: Canada
facility: Milestone Research Inc.
state: Ontario
city: Ottawa
country: Canada
facility: Red Maple Trials Inc.
state: Ontario
city: Stoney Creek
country: Canada
facility: Winterberry Family Medicine
state: Ontario
city: Sudbury
country: Canada
facility: Medicor Research Inc.
state: Ontario
city: Toronto
country: Canada
facility: Dr. Anil K. Gupta Medicine Professional Corporation
state: Ontario
city: Toronto
country: Canada
facility: Centricity Research Toronto Manna Multispecialty
state: Ontario
city: Chicoutimi
country: Canada
facility: Intermed groupe santé
state: Quebec
city: Pointe-Claire
country: Canada
facility: Centricity Research Pointe-Claire
state: Quebec
city: Pointe-Claire
country: Canada
facility: Manna Research Inc.
state: Quebec
city: Sherbrooke
country: Canada
facility: Q&T Research Sherbrooke Inc.
state: Quebec
city: Quebec
country: Canada
facility: Clinique spécialisée en allergie
city: Aichi
country: Japan
facility: Public Health Association.Inc
city: Fukuoka
country: Japan
facility: Tenjin Sogo Clinic
city: Hyogo
country: Japan
facility: Yamasaki Family Clinic - internal medicine
city: Kanagawa
country: Japan
facility: Motomachi Takatsuka Naika Clinic - Internal Medicine
city: Nagano
country: Japan
facility: Arakawa Family Clinic
city: Osaka
country: Japan
facility: Koseikai Yotsubashi Clinic - Internal Medicine
city: Sapporo
country: Japan
facility: Medical Corporation of Yamazaki Neurotology, Rhinolaryngology Clinic
city: Tokyo
country: Japan
facility: Dojinkinenkai Meiwa Hospital
city: Tokyo
country: Japan
facility: Medical Corporation Asbo Tokyo Asbo Clinic
city: Tokyo
country: Japan
facility: Metropolitan Clinic - Internal Medicine
city: Tokyo
country: Japan
facility: National Center for Global Health and Medicine
city: Tokyo
country: Japan
facility: Shinei Medical Healthcare Clinic
city: Barnsley
country: United Kingdom
facility: Barnsley Hospital
city: Bath
country: United Kingdom
facility: Royal United Hospital Bath NHS Trust - Royal United Hospital
city: Blackpool
country: United Kingdom
facility: Layton Medical Centre
city: Bournemouth
country: United Kingdom
facility: Dorset Clinical Research Centre (Bournemouth Hospital)
city: Bradford
country: United Kingdom
facility: Bradford Teaching Hospitals NHS Foundation Trust - Bradford
city: Corby
country: United Kingdom
facility: Lakeside Healthcare
city: Doncaster
country: United Kingdom
facility: Rotherham Doncaster and South Humber NHS Foundation Trust
city: Dundee
country: United Kingdom
facility: University of Dundee - NHS Tayside - Ninewells Hospital & Me
city: Edinburgh
country: United Kingdom
facility: Western General Hospital
city: Exeter
country: United Kingdom
facility: Royal Devon & Exeter Hospital
city: Glasgow
country: United Kingdom
facility: CPS Research
city: Glasgow
country: United Kingdom
facility: NHS Greater Glasgow & Clyde
city: Glasgow
country: United Kingdom
facility: Panthera Biopartners - Glasgow - multispeciality
city: Glasgow
country: United Kingdom
facility: Queen Elizabeth University Hospital
city: Gloucester
country: United Kingdom
facility: Gloucestershire Hospitals NHS Foundation Trust - Cheltenham
city: High Wycombe
country: United Kingdom
facility: Velocity Clinical Research High Wycombe
city: Leicester
country: United Kingdom
facility: University Hospitals of Leicester-Leicester Royal Hospital
city: London
country: United Kingdom
facility: Barts Health NHS Trust
city: London
country: United Kingdom
facility: Egin Research
city: London
country: United Kingdom
facility: Guys and St. Thomas NHS Foundation Trust
city: London
country: United Kingdom
facility: Hammersmith Medicines Research (HMR)
city: London
country: United Kingdom
facility: Panthera Biopartners - Enfield
city: London
country: United Kingdom
facility: Richford Gate Medical Practice
city: London
country: United Kingdom
facility: Royal Free London NHS Foundation Trust
city: London
country: United Kingdom
facility: St Georges Healthcare NHS Trust - University of London
city: Manchester
country: United Kingdom
facility: Manchester University NHS Foundation Trust
city: Milton Keynes
country: United Kingdom
facility: Bioluminux Clinical Research
city: Milton Keynes
country: United Kingdom
facility: Stemax Consult Healthcare Services Ltd
city: Newcastle
country: United Kingdom
facility: Newcastle University - Institute of Cellular Medicine (ICM)
city: North London
country: United Kingdom
facility: Velocity Clinical Research
city: Northwood
country: United Kingdom
facility: Accellacare North London
city: Nottingham
country: United Kingdom
facility: Nottingham University Hospitals NHS Trust - Queens Medical Centre (QMC) Campus
city: Peterborough
country: United Kingdom
facility: Wansford and Kings Cliffe Practice
city: Plymouth
country: United Kingdom
facility: University Hospitals Plymouth NHS Trust
city: Portsmouth
country: United Kingdom
facility: Southampton General Hospital - Portsmouth Research Hub
city: Preston
country: United Kingdom
facility: GST NHS Found
city: Preston
country: United Kingdom
facility: Panthera Biopartners Preston
city: Rochdale
country: United Kingdom
facility: Panthera Biopartners - Manchester - multispeciality
city: Runcorn
country: United Kingdom
facility: Warrington and Halton Teaching hospitals NHS Foundation Trust - Halton General Hospital
city: Sheffield
country: United Kingdom
facility: Panthera Biopartners - Sheffield - multispeciality
city: Sheffield
country: United Kingdom
facility: Royal Victoria Infirmary
city: Southampton
country: United Kingdom
facility: Southampton University Hospital NHS Foundation Trust
city: Weston-super-Mare
country: United Kingdom
facility: Pier Health Group
city: Weymouth
country: United Kingdom
facility: Weymouth Research Hub
city: Wrexham
country: United Kingdom
facility: North Wales Clinical Research Centre
Study officials:
References: