Clinical trial NCT03510013: 1-1-8 Wash-in for Sevoflurane Low Flow Anesthesia
Official title: 1-1-8 Wash-in for Sevoflurane Low Flow Anesthesia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Anesthesia
Keywords: low flow anesthesia
wash-in
sevoflurane
Lead sponsor: Khon Kaen University
Sponsor class: OTHER
First posted: 2018-04-27
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: All participants will receive sevoflurane 8% with O2:N2O or O2:air 1:1 L/min under controlled ventilation. Time to achieve alveolar concentration of sevoflurane of 1%, 1.5%, 2%, 2.5%, 3% and 3.5% will be recorded.
Primary purpose: TREATMENT

Brief summary: The investigators propose a new wash-in technique for sevoflurane low flow anesthesia with fresh gas flow of O2:N2O or O2:air 1:1 L/min with sevoflurane 8%.

The objective of this study is to identify time to achieve alveolar concentration of sevoflurane at 1, 1.5, 2, 2.5, 3, and 3.5%

Detailed description: The benefits of low flow anesthesia are economic, less pollution, more heat and humidity preservation but it requires appropriate wash-in phase. The current wash-in protocols for sevoflurane are complicated and time consuming. The investigators propose a new 1-1-8 sevoflurane wash-in protocol which is more simple and predictable.

The objective of this study is to identify time to achieve alveolar concentration of sevoflurane at 1, 1.5, 2, 2.5, 3, and 3.5% with 1-1-8 wash-in protocol.

All patients will receive iv propofol 2 mg/kg as induction agent and succinyl choline 1.5 mg/kg for intubation. Then the ventilation will be controlled to achieve end-tidal CO2 30-35 mmHg with O2:N2O or O2:air 1:1 L/min with sevoflurane 8%. Time to achieve alveolar concentration of sevoflurane at 1, 1.5, 2, 2.5, 3, and 3.5% will be recorded and analyzed. After that, the concentration of sevoflurane and anesthetic technique will be adjusted to requirement of anesthesiologist.

Eligibility criteria: Inclusion Criteria:

* ASA classification I-II
* age 18-65 years

Exclusion Criteria:

* BMI \> 35
* contraindicated for N2O
* • with pulmonary or cardiac disease

Primary outcomes:
measure: Time
timeFrame: participants will be followed until alveolar concentration of sevoflurane reaches 3.5%, as expected of 10 minutes
Secondary outcomes:
measure: Heart rate
timeFrame: participants will be followed until alveolar concentration of sevoflurane reaches 3.5%, as expected of 10 minutes]
measure: Blood pressure
timeFrame: participants will be followed until alveolar concentration of sevoflurane reaches 3.5%, as expected of 10 minutes]
Other outcomes:
Locations:
city: Khon Kaen
country: Thailand
facility: Faculty of Medicine, Khon Kaen University
Study officials:
affiliation: Faculty of Medicine, Khon Kaen University
name: Thepakorn Sathitkarnmanee, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Tribuddharat S, Sathitkarnmanee T, Vattanasiriporn N, Thananun M, Nonlhaopol D, Somdee W. 1-1-8 one-step sevoflurane wash-in scheme for low-flow anesthesia: simple, rapid, and predictable induction. BMC Anesthesiol. 2020 Jan 24;20(1):23. doi: 10.1186/s12871-020-0940-2.