louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05463471: Effect of Balanced Saline Solution and Albumin on Volume Expansion in Shock Patients
Official title: Effect of Balanced Saline Solution and Albumin on Volume Expansion in Shock Patients: a Prospective Randomized Controlled Study
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: PHASE4
Conditions: Shock
Keywords: shock
sodium acetate ringer
albumin
Lead sponsor: Peking Union Medical College Hospital
Sponsor class: OTHER
First posted: 2022-07-19
Enrollment: 500
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To compare the direct effect of sodium acetate ringer injection or albumin on volume expansion in shock patients, and to provide reference for volume resuscitation strategy in shock patients

Detailed description: CI/SVI increase amplitude and maintenance time

Eligibility criteria: Inclusion Criteria:

1. Age ≥ 18 years old, gender unlimited
2. Shock requires volume resuscitation:

   Insufficient tissue perfusion: wet and cold skin, decreased urine volume (\<0.5ml/kg/h), change of consciousness, blood lactate \>2.0mmol/l or vasoactive drugs are required to maintain map\>65mmhg
3. Presence of volume reactivity: (under controlled ventilation) PPV ≥ 15% or passive leg raising test (+) or (under controlled ventilation) IVC variability ≥ 18% or the presence of volume reactivity as judged by clinicians
4. The patient has no obvious restlessness, RASS ≤ 0
5. The legal representative of the subject signs the informed consent form-

Exclusion Criteria:

1. Pregnant and lactating women
2. End stage patients
3. BMI ≤ 15 or BMI ≥ 50
4. Contraindication of indwelling central vein catheter and invasive arterial catheter
5. Patients in ECMO and / or IABP therapy
6. Hemorrhagic shock, blood products such as concentrated red blood cells, plasma and platelets will be infused within 1 hour
7. Myocardial infarction, NYHA grade IV
8. Patients with hyperkalemia, hypercalcemia, hypermagnesemia and hypothyroidism
9. Allergic to compound sodium acetate ringer injection or albumin or with known side effects
10. Other factors that may affect the monitoring and evaluation of relevant indicators

Primary outcomes:
measure: Percentage of Cardiac output Index(CI) change
timeFrame: 2 hour
measure: Percentage of Stroke Volume Index（SVI）change
timeFrame: 2 hour
Secondary outcomes:
measure: Duration of Cardiac output Index(CI) change
timeFrame: 2 hour
measure: Duration of Stroke Volume Index（SVI）change
timeFrame: 2 hour
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01861171: Effect of Green Tea in Obese Pre-hypertensive Women
Official title: Effect of Green Tea on Adiposity, Metabolic Profile, Blood Pressure and Endothelial Function in Obese Pre-hypertensive Women
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obese
Hypertension
Lead sponsor: Rio de Janeiro State University
Sponsor class: OTHER
First posted: 2013-05-23
Enrollment: 30
Sex: ALL
Minimum age (years): 28
Maximum age (years): 59
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: SUPPORTIVE_CARE

Brief summary: The purpose of this study is to evaluate the effects of green tea on body weight, waist circumference, metabolic profile, inflammation, blood pressure and endothelial function in obese pre-hypertensive women.

Detailed description: Crossover randomized controlled double-blinded trial. Twenty women with obesity and pre-hypertension, aged 28-59 years, with stable body weight were randomized to receive a daily supplement of 3 capsules that contained either 500mg of green tea extract (GTE) or a matching placebo for 4 weeks, with a washout period of 2 weeks between the treatments. Endothelial function was evaluated by peripheral arterial tonometry method, using Endo-PAT 2000®.

Eligibility criteria: Inclusion Criteria:

pre-hypertensive women obese adult

Exclusion Criteria:

pregnant smoker elderly

Primary outcomes:
measure: Reduction of blood pressure
timeFrame: 12 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Rio de Janeiro
country: Brazil
facility: Pedro Ernesto Hospital Universitary
Study officials:
affiliation: Pedro Ernesto Universitary Hospital
name: Lívia P Nogueira
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04767971: Clinical Value of G-EYE Colonoscopy in Daily Practice for Adenoma Detection and Time for Polyp Removal
Official title: Clinical Value of G-EYE Colonoscopy in Daily Practice for Adenoma Detection and Time for Polyp Removal
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Adenoma
Colo-rectal Cancer
Keywords: Adenoma
Colorectal Cancer
Lead sponsor: Dr. Horst Schmidt Klinik GmbH
Sponsor class: INDUSTRY
First posted: 2021-02-23
Enrollment: 2795
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Screening and surveillance colonoscopy patients

Brief summary: Colonoscopy parameters will be compared before the introduction of the G-EYE endoscope and after the introduction of the G-EYE endoscope

Detailed description: Colonoscopy parameters such as demographics, findings and procedural times will be compared before the introduction of the G-EYE endoscope and after the introduction of the G-EYE endoscope

Eligibility criteria: Inclusion Criteria:

- Indication for screening or surveillance colonoscopy based on the German guideline for colon cancer screening

Exclusion Criteria:

* Emergency procedure
* Patients with known inflammatory bowel diseases
* Patients with hereditary cancer syndromes
* Patients with acute colonic inflammation (e.g. diverticulitis, ischemic colitis)
* Patients after radiation of the abdomen or pelvis
* Patients with colonic surgery (except appendectomy)
* Patients with incomplete colonoscopy
* Patients with insufficient bowel preparation

Primary outcomes:
measure: Detection rate - measured by adenoma detection rate (% subjects having at least 1 adenoma)
timeFrame: February 2021
measure: Effectiveness of intervention - measured by polyp removal time (mm:ss)
timeFrame: February 2021
Secondary outcomes:
Other outcomes:
Locations:
city: Wiesbaden
country: Germany
facility: Helios Dr. Horst Schmidt Kliniken
Study officials:
affiliation: Helios Dr. Horst Schmidt Kliniken Wiesbaden
name: Ralf Kiesslich, Prof.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03304171: Overall Diet Quality and Breast Cancer Risk
Official title: Diet Quality Scores and Risk of Incident Breast Cancer in Healthy Women
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Invasive Breast Cancer
Incident Breast Cancer
Lead sponsor: University of California, Irvine
Sponsor class: OTHER
First posted: 2017-10-06
Enrollment: 96959
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Female participants of the California Teachers Study who met the eligibility criteria.

The California Teachers Study is comprised entirely of female participants aged 22-104 years old at enrollment who were current and former public school teachers and administrators and completed a 16-page mailed questionnaire at study entry in 1995-1996. Details of the California Teachers Study (CTS) have been described previously (Bernstein L, et al.; 2002).

Brief summary: The purpose of this study was to examine the relationship between indices of overall diet quality and incident breast cancer risk in a large prospective cohort of women.

Detailed description: This study examined the role of overall diet quality on the risk of developing invasive breast cancer among 96,959 women in the California Teachers Study, in which 4,826 women were diagnosed with breast cancer during follow-up (1995-2011). Participants' dietary habits were recorded at baseline (1995) using a 103-item Block95 Food Frequency Questionnaire to allow for the assessment of overall diet quality. Specifically, diet quality was characterized by the Alternate Mediterranean Diet (aMED), Alternative Healthy Eating Index-2010 (AHEI-2010), Dietary Approaches to Stop Hypertension (DASH), and Paleolithic Index scores. Associations between diet quality and the risk of developing breast cancer were examined using multivariate Cox proportional hazard regression models to provide hazard ratios and corresponding 95% confidence intervals.

Eligibility criteria: Inclusion Criteria:

* Participants with no history of cancer diagnosis prior to baseline.
* Participants with no history of myocardial infarction prior to baseline.
* Participants with no history of stroke prior to baseline.
* Participants with no history of diabetes prior to baseline.
* Participants who are not missing excessive dietary data.
* Participants with energy intake values at ≥1% and ≤99% of the population distribution.

Primary outcomes:
measure: Incident Invasive Breast Cancer
timeFrame: 1995-2011
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Bernstein L, Allen M, Anton-Culver H, Deapen D, Horn-Ross PL, Peel D, Pinder R, Reynolds P, Sullivan-Halley J, West D, Wright W, Ziogas A, Ross RK. High breast cancer incidence rates among California teachers: results from the California Teachers Study (United States). Cancer Causes Control. 2002 Sep;13(7):625-35. doi: 10.1023/a:1019552126105.
Clinical trial NCT04836871: Double Filtration Plasmapheresis Combined With Chemotherapy
Official title: Clinical Research of Double Filtration Plasmapheresis Combined With Chemotherapy to Remove M Protein in Multiple Myeloma
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE1
Conditions: Multiple Myeloma
Lead sponsor: Zhongnan Hospital
Sponsor class: OTHER
First posted: 2021-04-08
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Evaluation of double filtration plasmapheresis combined with chemotherapy for the treatment of abnormalities of M protein or renal function due to the multiple myeloma.


Eligibility criteria: Inclusion Criteria:

* Multiple myeloma patients who are diagnosed by bone marrow morphology and immunology
* Patients with stable condition after conventional treatment
* Patients with renal insufficiency or abnormal M protein
* Patients over 18 years of age
* Liver function: blood bilirubin ≤ 35μmol/L, enzymes aspartate transaminase (AST)/aka alanine aminotransferase (ALT) is less than 2 times the upper limit of normal
* Normal heart function
* Physical condition score 0-2 level (ECOG score)
* Obtain an informed consent form signed by the patient or family member

Exclusion Criteria:

* Allergies or obvious contraindications to any of the drugs involved in the plan
* Severe heart disease, including myocardial infarction and cardiac insufficiency.
* Suffering from other organ malignancies
* Active tuberculosis patients and HIV-positive patients
* At the same time suffering from other blood system diseases
* Pregnant or lactating women
* Able to understand or follow the research plan
* Past history of intolerance or allergy to similar drugs
* Patients under 18 years of age
* Participating in other clinical researchers at the same time
* There are any other circumstances that hinder the progress of the research

Primary outcomes:
measure: M protein clearance rate
timeFrame: 1hour
measure: M protein clearance rate
timeFrame: 1hour
measure: creatinine clearance rate
timeFrame: 1hour
measure: creatinine clearance rate
timeFrame: 1hour
measure: albumin concentration
timeFrame: 1hour
measure: albumin concentration
timeFrame: 1hour
measure: serum-free light chain levels
timeFrame: 1hour
measure: serum-free light chain levels
timeFrame: 1hour
measure: blood urea nitrogen
timeFrame: 1hour
measure: blood urea nitrogen
timeFrame: 1hour
measure: Platelet concentrations
timeFrame: 1hour
measure: Platelet concentrations
timeFrame: 1hour
Secondary outcomes:
Other outcomes:
Locations:
city: Wuhan
country: China
facility: Zhongnan Hospital of Wuhan University
state: Hubei
Study officials:
References:
Clinical trial NCT07020871: Correlation of Dry Eye Disease, Problematic Smartphone Use and Sleep Quality in Adolescents and Young Adults
Official title: Correlation of Dry Eye Disease, Problematic Smartphone Use and Sleep Quality in Adolescents and Young Adults
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Dry Eye Disease (DED)
Keywords: dry eye disease
problematic smartphone use
sleep quality
bedtime procrastination
adolescents and young adults
Lead sponsor: Sun Yat-sen University
Sponsor class: OTHER
First posted: 2025-06-13
Enrollment: 453
Sex: ALL
Minimum age (years): 14
Maximum age (years): 35
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: General adolescents and young adults between 14-35 years old

Brief summary: The goal of this observational study is to learn about the status quo and relationship of dry eye, problematic smartphone use, bedtime procrastination, and sleep in adolescents and young adults. The main questions it aims to answer are:

* Is there a positive correlation between problematic smartphone use and dry eye?
* Is problematic smartphone use positively correlated with bedtime procrastination?
* Is bedtime procrastination negatively correlated with sleep quality?
* Is there a negative correlation between sleep quality and dry eye?
* Is there a negative correlation between problematic smartphone use and sleep quality?
* Is there a positive correlation between bedtime procrastination and dry eye?
* Do bedtime procrastination and sleep quality serve as mediating factors in the relationship of problematic smartphone use and dry eye? Participants will be asked to complete several questionnaires and dry eye related examinations.


Eligibility criteria: Inclusion Criteria:

* Adolescents and young adults aged 14 to 35 (including 14,25 years old) ;
* Agree to participate in the studies

Exclusion Criteria:

* Unable to communicate normally;
* With ocular surface diseases other than dry eye and autoimmune diseases;
* Use drugs that may cause damage to the ocular surface, such as anti glaucoma drugs, antidepressants, sex hormones, chemotherapy drugs, etc.;
* With a history of eye trauma or eye surgery;
* With a history of wearing contact lenses within the past month;
* Pregnant and lactating women

Primary outcomes:
measure: Dry eye symptoms
timeFrame: baseline
measure: Problematic smartphone use
timeFrame: baseline
measure: sleep quality
timeFrame: baseline
measure: bedtime procrastination
timeFrame: baseline
measure: dry eye signs
timeFrame: baseline
Secondary outcomes:
measure: Perceived level of stress
timeFrame: baseline
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Sun Yat-sen University
state: Guangdong
Study officials:
affiliation: Sun Yat-sen University
name: Wei Xia PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05781971: Effect of Nutritional Support and Early Rehabilitation on Sepsis
Official title: Department of Intensive Care Medicine, The First Affiliated Hospital of Soochow University
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Life Quality
Hospital Mortality
Lead sponsor: Jinling Hospital, China
Sponsor class: OTHER
Collaborators: name: The First Affiliated Hospital of Soochow University
First posted: 2023-03-23
Enrollment: 1600
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Sepsis is a syndrome of life-threatening organ dysfunction caused by a dysregulated host response to infection.Acute catabolic response in critically ill patients struck by sepsis, manifested by massive protein breakdown in a short time.This pathology frequently leads to prolonged hospitalization and mechanical ventilation, increased mortality, and reduced quality of survival.It is uncertainty whether sepsis patients in ICU can benefit from high protein intake combined with early exercise. Even though the combination has been shown to be beneficial in other populations.In the present study, the investigator will evaluate the effects of a combination of high protein targets combined with early rehabilitation in sepsis patients in ICU.

Detailed description: Existing research results confirm that high target protein support can reduce the mortality of sepsis patients. Early bedside rehabilitation has a good effect on cognitive function after ICU. This study combined high-protein nutritional support with bedside rehabilitation to improve the quality of life in patients with sepsis after ICU.

Eligibility criteria: Inclusion Standard

1. Patients with sepsis
2. Patients aged 18-70 years
3. Time of admission ≤48 h
4. Non-terminal condition

Exclusion Standard

1. Severe acute kidney injury
2. Severe chronic liver disease (MELD score ≥20) or acute hepatic failure
3. Protein allergy
4. Pregnancy and lactation
5. BMI≥30 kg/m²

Primary outcomes:
measure: Hospital Mortality
timeFrame: Day 90
Secondary outcomes:
measure: Nutrition related indicators
timeFrame: Hospital discharge
measure: Physical functioning
timeFrame: Hospital discharge
measure: Prognostic factor
timeFrame: Hospital discharge
measure: Health-related quality of life
timeFrame: Day 90
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT06520371: Percutaneous vs Conventional Radiofrequency Applications for the Treatment of Knee Osteoarthritic Pain
Official title: Comparison of Percutaneous and Conventional Radiofrequency Applications for the Treatment of Knee Osteoarthritic Pain: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Percutaneous
Conventional
Radiofrequency
Knee Osteoarthritis
Pain
Lead sponsor: Tanta University
Sponsor class: OTHER
First posted: 2024-07-25
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study aims to compare percutaneous and conventional radiofrequency applications for the treatment of knee osteoarthritic pain.

Detailed description: Osteoarthritis (OA) is a progressive degenerative joint disease that affects the joint cartilage and surrounding tissues. It mostly affects the weight-bearing joints, and in this respect, the knee joint is one of the joints that is most affected.

Radiofrequency (RF) treatment has been used for several painful conditions such as trigeminal neuralgia, cancer pain, and spinal pain. To destroy nerves or disrupt the transmission of pain signals, originally using producing heat lesions, RF current is applied to the trigeminal ganglion, the spinothalamic tracts of the spinal cord, the medial branches of posterior rami, and the dorsal root ganglion. In addition to these, there have been a few attempts to apply RF current for the treatment of painful conditions of joints of the extremities.

Percutaneous radiofrequency ablation (RFA) of articular sensory nerves has recently emerged as an attractive and minimally invasive approach to treat chronic pain due to large-joint osteoarthritis in select patients.

Eligibility criteria: Inclusion Criteria:

* Age \> 18 years old.
* Both sexes.
* Patients with knee osteoarthritis.
* Previous conservative treatments longer than 3 months.
* Visual analog scale (VAS)≥ 4.
* Radiological osteoarthritis grades 3 and 4 according to the Kellgren-Lawrence grading system (0 = none, 1 = doubtful, 2 = minimal, 3 = moderate, and 4 = severe).

Exclusion Criteria:

* Prior knee surgery.
* Allergies to local anesthetics.
* Connective tissue diseases affect the knee.
* Serious neurologic or psychiatric disorders.
* Injection with steroids or hyaluronic acids during the previous 3 months.
* History of septic arthritis.
* Sciatic pain.
* Cardiac pacemaker users.
* Anticoagulant medications.
* Prior electroacupuncture treatment.

Primary outcomes:
measure: Degree of pain
timeFrame: 12th week post-procedure
Secondary outcomes:
measure: Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) scores
timeFrame: 12th week post-procedure
measure: Patient satisfaction
timeFrame: 12th week post-procedure
measure: Incidence of adverse events
timeFrame: 12th week post-procedure
Other outcomes:
Locations:
city: Tanta
country: Egypt
facility: Tanta University
state: El-Gharbia
Study officials:
References:
Clinical trial NCT06732271: LC-Smart: A Deep Learning-Based Quality Control Model for Laparoscopic Cholecystectomy
Official title: LC-Smart: A Deep Learning-Based Quality Control Model for Laparoscopic Cholecystectomy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Laparoscopic Cholecystectomy
Lead sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Sponsor class: OTHER
First posted: 2024-12-13
Enrollment: 308
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: people with laparoscopic cholecystectomy

Brief summary: Objective: Critical view of safety (CVS) is a successful technique to reduce bile duct injury during laparoscopic cholecystectomy (LC). We aimed to create a deep learning-based quality control model for LC and reduce the learning curve for junior surgeons, which would automatically assess whether surgeons are CVS conscious during procedures.Methods: We retrospectively collected 308 LC videos from public datasets (Cholec80, Endoscapes) and Sun Yat-sen Memorial Hospital. Video frames were labeled using binary classification and feature optimization methods, such as black border clipping and sliding windows. Two neural networks, ResNet-50 and EfficientNetV2-S, were trained and evaluated based on F1 scores and accuracy. Additionally, We created an online CVS recognition system (LC-Smart), tested it using 171 films from two hospitals, and compared the results to two local senior doctors.


Eligibility criteria: Inclusion Criteria:

* complete video data with no missing footage;
* surgical procedure identified as laparoscopic cholecystectomy;
* full visibility of the surgical area in the video;
* successful completion of the procedure;
* absence of significant anatomical variations
* video resolution no less than 720×560.

Exclusion Criteria:

* substantial intraoperative adhesions
* a history of previous abdominal or pelvic procedures
* a conversion to open surgery during the procedure
* significant bleeding that obscured structural identification.

Primary outcomes:
measure: the surgical time
timeFrame: Nov/2023-Nov/2024
Secondary outcomes:
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Sun Yat-sen Memorial Hospital,SUn Yat-sen UNiversity
state: Guangdong
Study officials:
References: