Clinical trial NCT03903328: Prevalence of Sarcopenia Among Elderly Living in Care Facilities in Klang Valley, Malaysia
Official title: A Preliminary Study of Prevalence of Sarcopenia Among Elderly Living in Care Facilities in Klang Valley, Malaysia
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Sarcopenia
Sarcopenic Obesity
Keywords: muscle strength
physical performance
Sarcopenia
Lead sponsor: Universiti Tunku Abdul Rahman
Sponsor class: OTHER
First posted: 2019-04-04
Enrollment: 205
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Elderly living in long-term care facilities (Institutionalized elderly) in Klang valley. Only Seven facilities allowing access to the study subjects were studied

Brief summary: The primary aim of this study was to investigate the prevalence of age-related progressive decline in muscle mass and strength (Sarcopenia) among Malaysian elderly residing in long-term care facilities. It is a very important condition to study as it is associated with high incidence of fall, hospitalization and mortality.

Detailed description: Over the past few decades, one condition that prominently affects the muscular system, known as sarcopenia, has captured the attention of healthcare experts and researchers. Sarcopenia is a geriatric syndrome characterized by the involuntary, gradual and generalized deterioration of skeletal muscle mass and strength with advancing age. It is to be noted that while sarcopenia is predominantly a syndrome of the elderly, its development may also be observed in various conditions such as disuse, malnutrition and cachexia, all of which are not exclusive only to the elderly. As of now, there are still ongoing research on an international scale with regards to its epidemiology, risk factors, causative factors, adverse clinical complications, prevention and treatment.

Beginning in 1st of October, 2016, Centres for Disease Control and Prevention (CDC) has finally officialised an International Classification of Diseases, Tenth Revision, Clinical Modification (ICD-10- CM) code for sarcopenia after its final proposal since April 2015. This establishment has enabled comprehensible clinical guidelines for diagnosis and treatment of sarcopenia, as well as separate reporting and data collection for sarcopenia in the medical community.

In essence, sarcopenia appears to be one of the most important causes of functional impairment, physical disability and loss of independence in older adults and a prevalence study will help to estimate the deleterious effects of this condition on the elderly living in the care facility, who happen to be the less privileged group as compared to their counterparts dwelling in the community.

Eligibility criteria: Inclusion Criteria:

* Currently residing in a long-term care facility
* Ability to walk, with or without the use of any walking aid
* Citizen of Malaysia

Exclusion Criteria:

* Inability to stand for height, weight and gait speed assessments
* Presence of cardiac pacemaker
* Presence of artificial limbs / prosthesis / metal implants
* Difficult or dangerous behaviours
* Severe cardiac, pulmonary, or musculoskeletal disorders
* Severe cognitive impairment or any disability that makes communication impossible
* Presence of terminal illness
* Co-morbidities associated with high risk of falls (e.g. Parkinson's disease or CVA) or that may directly influence affect gait speed

Primary outcomes:
measure: Skeletal muscle mass
timeFrame: 10 minutes
measure: Grip strength
timeFrame: 1 minute to 10 minutes
measure: Gait speed
timeFrame: less the 10 minutes on an average
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Universiti Tunku Abdul Rahman
name: PRAMOD D SHENOY, MPT
role: PRINCIPAL_INVESTIGATOR
affiliation: Universiti Tunku Abdul Rahman
name: sook Fan Yap, FRCP (UK)
role: STUDY_DIRECTOR
References:
citation: Abizanda P, Navarro JL, Garcia-Tomas MI, Lopez-Jimenez E, Martinez-Sanchez E, Paterna G. Validity and usefulness of hand-held dynamometry for measuring muscle strength in community-dwelling older persons. Arch Gerontol Geriatr. 2012 Jan-Feb;54(1):21-7. doi: 10.1016/j.archger.2011.02.006. Epub 2011 Mar 2.
citation: Abridged Life Tables, Malaysia, 2012-2015. (2015). Department of Statistics Malaysia. Retrieved from: https://www.statistics.gov.my/index.php?r=column/pdfPrev&id=cWxzRWcvMTZrWFp4UStqQmp3MG9QZz09
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citation: Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM, Topinkova E, Vandewoude M, Zamboni M; European Working Group on Sarcopenia in Older People. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010 Jul;39(4):412-23. doi: 10.1093/ageing/afq034. Epub 2010 Apr 13.
citation: Cruz-Jentoft AJ, Landi F, Schneider SM, Zuniga C, Arai H, Boirie Y, Chen LK, Fielding RA, Martin FC, Michel JP, Sieber C, Stout JR, Studenski SA, Vellas B, Woo J, Zamboni M, Cederholm T. Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. Report of the International Sarcopenia Initiative (EWGSOP and IWGS). Age Ageing. 2014 Nov;43(6):748-59. doi: 10.1093/ageing/afu115. Epub 2014 Sep 21.