Clinical trial NCT02827383: Pilot Stair Climbing Study
Official title: Pilot Study to Test the Effect of Fractionalized Vigorous-Intensity Activity on Acute Glucose in Adults at Risk for Type 2 Diabetes
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Prediabetic State
Lead sponsor: University of Georgia
Sponsor class: OTHER
Collaborators: name: University of Illinois at Urbana-Champaign
First posted: 2016-07-11
Enrollment: 10
Sex: ALL
Minimum age (years): 40
Maximum age (years): 64
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: PREVENTION

Brief summary: This pilot study seeks to demonstrate feasibility to conduct data collection and illustrate potential for effect of fractionalized bouts of stair climbing on glucose control in adults at risk for type 2 diabetes.

Detailed description: Objective: Compare the short-term effects of two different fractionalized stair climbing bout protocols on glucose control among adults at risk for type 2 diabetes.

Rationale: Fractionalized physical activity is associated with reduced BMI, glycated hemoglobin, lower 2-hr plasma glucose and insulin sensitivity in cross-sectional studies. Yet, few studies have examined the effects of fractionalized or intermittent physical activity in a prospective manner. Furthermore, the research is limited to patients with diagnosed type 2 diabetes, or using exercise of a moderate intensity.

The hypothesis is that stair climbing, a vigorous-intensity activity, may have a greater health effect. However, this has not been tested in short bouts of activity that are spread out during a day.

Implications: Fractionalized physical activity may be more feasible for adults at risk for, or with diagnosed type 2 diabetes who are not currently active. These short bouts can increase energy expenditure throughout the day, rather than in one long continuous bout as currently recommended.

Eligibility criteria: Inclusion Criteria:

* Age greater than 40 years but less than 65 years (working age adult with reduce physiologic capacity to regulate glucose)
* BMI of overweight or obese (25.0 to 35.0)
* Answered "No" to all questions on the Physical Activity Readiness Questionnaire, or has physician approval to participate
* Hemoglobin A1C% value in the at-risk range of 5.7 to 6.4

Exclusion Criteria:

* Unable to physically perform stair climbing
* Currently exercising for 60 or more minutes weekly.
* Weight over 275 lbs (because stair climbing machine has a weight limit)

Primary outcomes:
measure: Continuous Glucose Monitor
timeFrame: Up to 5 days
Secondary outcomes:
measure: Heart Rate
timeFrame: 2 Intervention Days
Other outcomes:
Locations:
city: Athens
country: United States
facility: Clinical and Translational Research Unit, University of Georgia
state: Georgia
Study officials:
affiliation: University of Georgia
name: Jennifer L Gay, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Gay JL, Buchner DM, Erickson ML, Lauture A. Effect of short bouts of high intensity activity on glucose among adults with prediabetes: A pilot randomized crossover study. Diabetes Res Clin Pract. 2018 Jul;141:168-174. doi: 10.1016/j.diabres.2018.04.045. Epub 2018 May 7.