Clinical trial NCT06304298: NLR and PLR Levels Following IPACK Block in Knee Arthroplasty
Official title: The Neutrophil-to-lymphocyte Ratio (NLR) and Platelet-to-lymphocyte Ratio (PLR) Levels Following IPACK Block in Knee Arthroplasty: a Randomized, Controlled Trial.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Knee Arthropathy
Knee Osteoarthritis
Knee Pain Chronic
Lead sponsor: Poznan University of Medical Sciences
Sponsor class: OTHER
First posted: 2024-03-12
Enrollment: 60
Sex: ALL
Minimum age (years): 20
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Effect of iPACK block on NLR and PLR following knee arthroplasty

Detailed description: The NLR is a sensitive indicator of inflammation confirmed in numerous studies and has a predictive and prognostic value. NLR is a cheap, simple, fast-acting, readily available stress and inflammation parameter with high sensitivity and low specificity. Dynamic changes in the NLR precede the clinical state for several hours and may alert clinicians early about the ongoing pathological process. NLR is a new promising marker of cellular immune activation, an important indicator of stress and systemic inflammation. It opens a new dimension for clinical medicine to understand better the biology of inflammation, the linkage, and antagonism between innate and adaptive immunity, and its clinical consequences for health and disease.

NLR is affected not only by surgical trauma but also by the method of anesthesia. In recent years, the influence of regional anesthesiology on reducing the inflammatory response after surgical procedures has been emphasized. However, there have been very few studies evaluating the effect of various methods of anesthesia on the NLR.

This is the first study to investigate the effect of regional anesthesia on the NLR and PLR in patients undergoing knee replacement surgery.

Eligibility criteria: Inclusion Criteria:

* Patients with ASA classification I-III
* Aged 20-90 years
* Who will be scheduled for hip arthroplasty under spinal anesthesia

Exclusion Criteria:

* Patients who have a history of bleeding diathesis
* Take anticoagulant therapy
* History of chronic pain before surgery
* Multiple trauma
* patients unable to assess their pain (dementia)
* patients operated under general anesthesia
* patients having an infection in region of the procedure
* patient who do not accept the procedure

Primary outcomes:
measure: Neutrophil-to-lymphocyte ratio
timeFrame: 12 hours after surgery
Secondary outcomes:
measure: PLR
timeFrame: 12 hours after surgery
measure: PLR
timeFrame: 24 hours after surgery
measure: PLR
timeFrame: 48 hours after surgery
measure: NLR
timeFrame: 24 hours after surgery
measure: NLR
timeFrame: 48 hours after surgery
measure: first need of opiate
timeFrame: 48 hours after procedure
measure: Opioid Consumption
timeFrame: 48 hours after surgery
measure: Pain score
timeFrame: 4 hours after surgery
measure: Pain score
timeFrame: 8 hours after surgery
measure: Pain score
timeFrame: 12 hours after surgery
measure: Pain score
timeFrame: 18 hours after surgery
measure: Pain score
timeFrame: 24 hours after surgery
measure: Pain score
timeFrame: 36 hours after surgery
measure: Pain score
timeFrame: 48 hours after surgery
Other outcomes:
Locations:
city: Poznan
country: Poland
facility: Poznan University of Medical Sciences
state: Poznań
Study officials:
affiliation: Poznań University of Medical Sciences
name: Małgorzata Domagalska, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References: