Clinical trial NCT02069028: Effectiveness of Different Interventions for Implementing Surviving Sepsis Campaign (SSC) Guidelines on Compliance and Mortality: Systematic Review and Meta-analysis
Official title: Effectiveness of Different Interventions for Implementing Surviving Sepsis Campaign (SSC) Guidelines on Compliance and Mortality: Systematic Review and Meta-analysis
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Sepsis
Septic
Septicemia
Keywords: surviving sepsis campaign
sepsis
septic
septicemia
mortality
compliance
Lead sponsor: King Abdullah International Medical Research Center
Sponsor class: OTHER
First posted: 2014-02-21
Enrollment: 30
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Research articles

Brief summary: This is a systematic review and Meta-Analysis of interventions for implementation of Surviving Sepsis Campaign guidelines and their impact on compliance and mortality reduction

Detailed description: The implementation of the sepsis resuscitation bundle recommended by the SSC guidelines has been shown to increase compliance and reduce mortality in several settings. Different implementation strategies have been utilized, including education, posters, reminders, audit and feedback, paper-based and electronic sepsis screening tools, clinical pathway and sepsis response teams. Different studies showed a considerable variation effect on compliance and mortality.It has been suggested that implantation strategies vary in there effect from low impact for human-based interventions such as education and training, rules and policies, reminders, checklists and double checks, however, reaching high effect for system based interventions like automation and computerization and forcing function. However, this has not been studied in relation to the implementation of SSC bundle. As such, many projects continue to invest on low-impact interventions with modest change in compliance and mortality. Multiple interventions were adopted by different centers worldwide to implement SSC guidelines. These interventions vary on their level of compliance and outcomes. The effectiveness of intervention if system oriented is more effective than human oriented. The hierarchy of effectiveness assigning forcing function intervention on the top of the pyramid and the training and education on the bottom.

The investigators hypothesize that interventions system based interventions are more likely to be more effective in improving the compliance with sepsis resuscitation bundle and in improving mortality.

The aim of this study is to assess the effectiveness of different interventions for implementation of Surviving Sepsis Campaign guidelines and their impact on compliance and mortality reduction.

Eligibility criteria: Inclusion Criteria:

Any study or data

1. assessing any intervention method for implementing SSC guidelines in regards to compliance and mortality,
2. has a comparison group,
3. reported data on sepsis resuscitation bundle compliance and mortality

Exclusion Criteria:

Any study used other than SSC guidelines in sepsis management will be excluded.

Primary outcomes:
measure: Surviving Sepsis Campaign (SSC) Guidelines Compliance and Mortality
timeFrame: 2002 - 2014 (12 years)
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References: