louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00347997: A Study to Evaluate the Safety and Effectiveness of the 217z Laser With Zyoptix for Lasik
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: NA
Conditions: Myopia
Astigmatism
Lead sponsor: Bausch & Lomb Incorporated
Sponsor class: INDUSTRY
First posted: 2006-07-04
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: A Study to demonstrate the safety and efficacy of wavefront laser refractive surgery treatments for myopia and astigmatism.


Eligibility criteria: Inclusion Criteria:

* Myopia with or without astigmatism.

Exclusion Criteria:

* Contraindications to LASIK.

Primary outcomes:
measure: Visual acuity
timeFrame: 24 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Bausch & Lomb Incorporated
name: Mohinder Merchea, OD, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT05872997: Effectiveness of Mobilization With Movement Along With Sensory Motor Training in Patients With Knee Osteoarthritis
Official title: Effectiveness of Mobilization With Movement Along With Sensory Motor Training in Patients With Knee Osteoarthritis
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Knee Osteoarthritis
Lead sponsor: Superior University
Sponsor class: OTHER
First posted: 2023-05-24
Enrollment: 36
Sex: ALL
Minimum age (years): 45
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: to find out the Effectiveness of Mobilization With Movement Along With Sensory Motor Training in Patients With Knee Osteoarthritis


Eligibility criteria: Inclusion Criteria:

* Both genders between age of 45 and 70 with knee pain more than 3 months of presentation in outpatient department. They were also required to stand independently from sitting and prone lying

Exclusion Criteria:

* Patients with any lower limb fractures, any neurological condition, contraindication to manual therapy, post traumatic Knee osteoarthritis, total knee replacement, uncontrolled hypertension, and radiating leg pain

Primary outcomes:
measure: Oxford Scale
timeFrame: 6 Months
measure: Numeric Pain Scale
timeFrame: 6 Months
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Chaudary Muhammad Akram Teaching Hospital
state: Punjab
Study officials:
References:
Clinical trial NCT02812797: Prognostic Value of Adipokine Levels of Patients With Chronic Heart Failure
Official title: Prognostic Value of Adipokine Levels of Patients With Chronic Heart Failure
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Chronic Heart Failure
Keywords: Adipokines
Chronic Heart Failure
Prognosis
Lead sponsor: Chongqing Medical University
Sponsor class: OTHER
First posted: 2016-06-24
Enrollment: 98
Sex: ALL
Minimum age (years): 12
Maximum age (years): 80
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients With Chronic Heart Failure

Brief summary: The purpose of this study is to determine whether expressions of adipokines can provide prognostic information concerning patients with chronic heart failure.


Eligibility criteria: Inclusion Criteria:

* Patients who are giving open chest surgical treatment with a history of chronic heart failure (NYHA II \~ IV) more than 6 months.
* Patients from whom informed consent has been properly obtained in writing prior to start of the trial.

Exclusion Criteria:

* Patients with concurrent infection or any documented inflammatory illness, such as arthritis or connective tissue diseases,or any other malignancy.
* Patients with a history of cardiomyopathy.
* Patients with Chronic arrhythmia.
* Pregnant women
* Severe hepatic dysfunction or End-stage renal failure.
* Uncontrolled hypertension.

Primary outcomes:
measure: All-cause mortality
timeFrame: Change from Baseline at 3, 6 and 12 months
Secondary outcomes:
measure: New York Heart Association (NYHA) Classification
timeFrame: Week:4
measure: re-hospitalization
timeFrame: Change from Baseline at 3, 6 and 12 months
measure: plasma brain natriuretic peptide (BNP) concentration
timeFrame: Week:4
measure: Cardiovascular death
timeFrame: Change from Baseline at 3, 6 and 12 months
measure: Cardiac transplantation
timeFrame: Change from Baseline at 3, 6 and 12 months
Other outcomes:
Locations:
city: Chongqing
country: China
facility: The First Affiliated Hospital of Chongqing Medical University
state: Chongqing
Study officials:
affiliation: Chongqing Medical University
name: Dongying Zhang, doctor
role: STUDY_DIRECTOR
References:
Clinical trial NCT04091997: Macrophage Migration Inhibitory Factor for Diagnosing Endometriosis and Its Severity
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Endometriosis
Keywords: Macrophage migration inhibitory factor
Endometriosis
Laparoscopy
Lead sponsor: Fayoum University Hospital
Sponsor class: OTHER
First posted: 2019-09-17
Enrollment: 300
Sex: FEMALE
Minimum age (years): 19
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Both groups were comparable regarding the baseline characteristics. these included age, parity, Body mass index, symptoms, type of infertility and chronic pelvic pain

Brief summary: Endometriosis is a chronic disease affecting women of reproductive age. Macrophage migration inhibitory factor (MIF) is one of non-invasive blood biomarker that was detected in sera of endometriotic patients.The aim of this study was to evaluate the value of serum macrophage migration inhibitory factor in diagnosing endometriosis in women with infertility and chronic pelvic pain and correlate its level with the stage of the disease. Three hundred patient candidate for diagnostic laparoscopy were included in a case-control observational study

Detailed description: observational case-control study conducted in Fayoum University hospital from March 2016 till September 2018. Three hundred women candidate for diagnostic laparoscopy for either infertility or gynecologic chronic pelvic pain were included. The study group included patients with diagnostic criteria of endometriosis. The control group included other causes of infertility or pelvic pain.

Eligibility criteria: Inclusion Criteria:

* postmenstrual women
* in childbearing period,
* presenting with either gynecologic chronic pelvic pain (CPP) or infertility
* indicated and fit for diagnostic laparoscopy.
* All women must have no hormonal treatment for the last 3 months and.

Exclusion Criteria:

* Women with bleeding tendency,
* suspicious of gynecologic malignancy or
* active infection

Primary outcomes:
measure: level of serum macrophage migration inhibitory factor and stage of the disease
timeFrame: one year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT00945997: Misoprostol for Second Trimester Termination of Pregnancy
Official title: Mifepristone (RU 486) and Misoprostol for Second Trimester Termination of Pregnancy. A Comparison of Two Different Dose Regimens.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Termination of Pregnancy Second Trimester
Keywords: misoprostol
mifepristone
medical abortion
randomised controlled trial
Lead sponsor: Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Sponsor class: OTHER
First posted: 2009-07-24
Enrollment: 176
Sex: FEMALE
Minimum age (years): 16
Maximum age (years): 60
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To compare the efficacy of two different dose regimens of misoprostol administered vaginally in combination with mifepristone in second trimester termination of (non)viable pregnancy.

Detailed description: The study was designed as a prospective double blinded randomised controlled trial, comparing 200µg to 400 µg misoprostol given vaginally at four hour intervals, starting 36-48 hours after the oral administration of mifepristone 200 mg at a gestational age between 14 to 24 weeks.

Eligibility criteria: Inclusion Criteria:

* Women with a gestational age between 14 to 24 weeks, confirmed by ultrasound, requesting termination of pregnancy

Exclusion Criteria:

* No informed consent
* Mifepristone allergy
* Chronic adrenal gland failure
* Kidney failure
* Liver failure
* Chronic use of corticosteroids
* COPD not responsive to treatment
* Cardiovascular disease
* Glaucoma

Primary outcomes:
measure: Expulsion rate and the number of incomplete abortions warranting surgical evacuation of retained products of conception.
timeFrame: 8 weeks
Secondary outcomes:
measure: time between the first administration of misoprostol to to delivery of the foetus
timeFrame: 48 hours
Other outcomes:
Locations:
city: Amsterdam
country: Netherlands
facility: Academic Medical Center
Study officials:
References:
Clinical trial NCT01909297: Comparison of the I-gel, Supreme and Proseal LMA in Paralyzed Patients
Official title: Comparison of the I-gel, Supreme and Proseal LMA in Paralyzed Patients Undergoing Gynaecological Laparoscopic Surgery With Oropharyngeal Leak Pressure
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Airway Complication of Anaesthesia
Keywords: airway management
Lead sponsor: Inonu University
Sponsor class: OTHER
First posted: 2013-07-26
Enrollment: 35
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The investigators aimed to compare of the i-gel, supreme and proseal laryngeal mask airways in paralysed patients undergoing gynaecological laparoscopic surgery with oropharyngeal leak pressure. The investigators also studied their relative ease of insertion, time to insertion and complications of use as secondary outcome measures.

Detailed description: A total of 105 patients scheduled for elective gynaecological laparoscopic procedures in our Inonu University Medical Faculty Hospital were recruited.They were equally randomized into three groups: PLMA, supreme and i-gel groups. All three devices were compared with regard to oropharyngeal leak pressure, number and duration of insertion attempts and complications of airway. Oropharyngeal leak pressure will evaluate including to start,trendelenburg and postoperative at period. Fiberoptic evaluation of the LMA's position were performed after successful insertion and determination of the airway pressures. After one hour patients were evaluated by a blinded independent observer for postoperative complications ( sore throat, dysphonia and dysphagia).

Eligibility criteria: Inclusion Criteria:

* 18- 60 YEARS

Exclusion Criteria:

* ASA 3-4 patients
* BMI 40

Primary outcomes:
measure: change of oropharyngeal leak pressure
timeFrame: 10min, 30 min ,45 min
Secondary outcomes:
measure: easiness of insertion of the device
timeFrame: 2 min
Other outcomes:
measure: postoperative complication
timeFrame: 2 hour after operation
Locations:
city: Malatya
country: Turkey
facility: Inonu University
Study officials:
affiliation: Assistant Prof Dr
name: mukadder sanli, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Singh I, Gupta M, Tandon M. Comparison of Clinical Performance of I-Gel with LMA-Proseal in Elective Surgeries. Indian J Anaesth. 2009 Jun;53(3):302-5.
Clinical trial NCT02916797: Stepping Training Using Feedback in Stroke
Official title: Effects of Stepping Training With and Without the Use of Visually Weight-taking Machine (VWTM) on Walking and Balance Ability in Patients With Stroke
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cerebrovascular Accident
Keywords: Feedback
Physical Therapy
Lead sponsor: Khon Kaen University
Sponsor class: OTHER
First posted: 2016-09-27
Enrollment: 36
Sex: ALL
Minimum age (years): 45
Maximum age (years): 74
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: * Are there differences in immediate effects of stepping training with and without the use of visually weight-taking machine (VWTM) on variables relating to well-controlled walking and walking symmetry in ambulatory patients with stroke?
* Are there differences of 4-week stepping training with and without the use of VWTM on variables relating to well-controlled walking and walking symmetry in ambulatory patients with stroke?

Detailed description: * To compare immediate effects of stepping training with or without the use of VWTM on variables relating to well-controlled walking and walking symmetry in ambulatory patients with stroke.
* To compare effects of 4-week stepping training with or without the use of VWTM on variables relating to well-controlled walking and walking symmetry in patients with stroke.

Eligibility criteria: Inclusion Criteria:

* Subjects are independent ambulatory patients with first stroke episode with the age at least 45-74 years old,
* subacute (post-stroke time \< 6 months) or chronic (post-stroke time ≥ 6 months) stroke
* Independent walking at least 10 meters with or without a walking device
* Able to follow verbal command used in this study

Exclusion Criteria:

* The subjects who have other medical conditions that might affect participation in the study such as uncontrolled underlying diseases (i.e. hypertension, heart disease, thyroid, etc.), deformity in the lower extremities, pain more than 5 out of 10 on a visual analog scale, legally blind or had a history of visual deficits that were unable to be corrected by glasses or contact lens, have a color blindness and inability to communicate or follow the commands used in this study

Primary outcomes:
measure: 10MWT
timeFrame: 4 weeks
Secondary outcomes:
measure: 6MWT
timeFrame: 4 weeks
measure: TUGT
timeFrame: 4 weeks
measure: Lower limb support ability
timeFrame: 4 weeks
Other outcomes:
Locations:
Study officials:
affiliation: School of Physical Therapy,Faculty of Associated Medical Sciences, Khon Kaen University, Thailand
name: Sugalya Amatachay, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01261897: The Efficacy of Adductor-Canal-Blockade on Pain and Morphine Consumption After Total Knee Arthroplasty
Official title: The Efficacy of Adductor-Canal-Blockade on Pain and Morphine Consumption After Total Knee Arthroplasty
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Postoperative Pain
Knee Arthroplasty
Keywords: Adductor-Canal-Blockade
postoperative pain
US-guided nerve block
total knee arthroplasty
Lead sponsor: Rigshospitalet, Denmark
Sponsor class: OTHER
First posted: 2010-12-17
Enrollment: 40
Sex: ALL
Minimum age (years): 40
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The objective of this study is to assess the efficacy of Adductor-Canal-Blockade on pain and morphine consumption after total knee arthroplasty. Our hypothesis is that the Adductor -Canal-Blockade is superior to placebo in reducing pain and morphine consumption after total knee arthroplasty.


Eligibility criteria: Inclusion Criteria:

* Total Knee Arthroplasty in general anaesthesia
* ASA 1-3
* BMI 18-40
* Written informed consent

Exclusion Criteria:

* Can not cooperate to the exam
* Do not speak or understand Danish
* Drug allergy
* Alcohol or drug abuse
* Daily consumption of strong opioids

Primary outcomes:
measure: Pain during 45 degrees active flexion of the knee
timeFrame: 1 hour postoperative
Secondary outcomes:
measure: Pain during 45 degrees active flexion of the knee
timeFrame: 0-6 hours postoperative
measure: Pain during rest
timeFrame: 1-6 hours postoperative
measure: A change in pain score in the ropivacaine group, after activating the block
timeFrame: 30-60 minutes postoperative
measure: Total morphine consumption
timeFrame: 30 minutes - 6 hours postoperative
measure: Postoperative nausea
timeFrame: 1-6 hours postoperative
measure: Postoperative vomiting
timeFrame: 1-6 hours postoperative
measure: Zofran consumption
timeFrame: 1-6 hours postoperative
measure: Sedation
timeFrame: 1-6 hours postoperative
Other outcomes:
Locations:
city: Gentofte
country: Denmark
facility: Department of Anaesthesia-Surgery-Intensive Care, Gentofte Hospital
state: Hellerup
Study officials:
affiliation: Rigshospitalet, Denmark
name: Pia Jæger, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Jaeger P, Grevstad U, Henningsen MH, Gottschau B, Mathiesen O, Dahl JB. Effect of adductor-canal-blockade on established, severe post-operative pain after total knee arthroplasty: a randomised study. Acta Anaesthesiol Scand. 2012 Sep;56(8):1013-9. doi: 10.1111/j.1399-6576.2012.02737.x. Epub 2012 Jul 26.
Clinical trial NCT06807697: Quality of Life Before and After Radiotherapy in Patients With Head and Neck Cancer
Official title: A Pilot Investigation of the Quality of Life Before and After Radiotherapy in Patients With Head and Neck Cancer
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Head and Neck Cancer
Quality of Life (QOL)
Keywords: Quality of Life
Head and Neck Cancer
Radiotherapy
Lead sponsor: University of Turin, Italy
Sponsor class: OTHER
First posted: 2025-02-04
Enrollment: 22
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with Head and Neck Cancer and waiting to undergo curative radiotherapy. HNC patients attach great importance to their health-related quality of life. In addition, there is evidence that the QoL of HNC survivors is poorer than that of the general population due to the significant functional limitations caused by the disease and treatment, this is because the head and neck district is the site of several organs that play an important role in the basic functions of daily life, including breathing, speeching, chewing, and swallowing, and are important for appearance. Moreover, HNC leads to a high incidence of psychosocial problems among survivors, such as depression, social isolation, and addiction and substance abuse, which in turn post to negative consequences with regard to QoL.

Brief summary: Worldwide, head and neck cancers (HNCs) are widespread (650,000 cases per year) and cause more than 330,000 deaths per year. Almost all cases, about 90%, are cancers of the oral cavity, oropharynx, and larynx.

In conventional clinical practice, HNCs are treated primarily with radiation therapy (RT), often used in combination with surgery and/or chemotherapy. Like most anti-neoplastic therapies, RT carries significant adverse effects both acute and chronic. Both types of adverse effects have a significant impact on quality of life (QoL).

The aim of the study is to examine the worsening of QoL in patients with HNC before and after cancer therapy and to assess the extent that each factor has in its worsening.


Eligibility criteria: Inclusion Criteria:

* patients between the ages of 18 and 75 years;
* patients who presented at their first dental visit with a diagnosis of HNC.

Exclusion Criteria:

* patients who had already undergone cancer therapies (excisional surgery or chemotherapy or radiation therapy) at the time of the first dental visit;
* patients with depression or social anxiety;
* patients with language difficulties.

Primary outcomes:
measure: University of Washington Quality of Life Questionnaire version 4.1
timeFrame: 1 month
Secondary outcomes:
Other outcomes:
Locations:
city: Torino
country: Italy
facility: AOU Città della Salute e della Scienza
Study officials:
References:
Clinical trial NCT05096897: Oral Health-related Quality of Life (OHRQoL) in Patients With Inflammatory Bowel Disease (IBD)
Official title: Self-rated Oral Health and Factors Associated With Oral Health-related Quality of Life (OHRQoL) in Patients With Inflammatory Bowel Disease (IBD)
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Inflammatory Bowel Diseases
Periodontitis
Dental Caries
Tooth Loss
Keywords: Crohn disease
Ulcerative Colitis
oral diseases
Oral health-related quality of life
self-questionnaire
Lead sponsor: University Hospital, Lille
Sponsor class: OTHER
First posted: 2021-10-27
Enrollment: 122
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: outpatients of the Service of Gastroenterology of the CHU of Amiens

Brief summary: IBD patients have a higher risk of oral diseases that affect the oral mucosa, the teeth and the tooth supporting tissues. These conditions are often associated with pain, bleeding and impaired masticatory function which may have an impact on the oral health-related quality of life (OHRQoL). However, few studies have investigated the self-evaluation of oral quality of life in IBD patients. The rare existing studies focus on very specific patients (elderly patients, patients with stomas) and do not use validated tools for the evaluation of OHRQoL. We also lack data on the effect of treatments such as immunosuppressants and type of IBD on OHRQoL. The aim of this study is to (i) compare oral quality of life in a cohort of IBD patients versus non-IBD patients and (ii) explore potential factors that influence oral quality of life in IBD


Eligibility criteria: Inclusion Criteria:

* Adults ≥ 18 years of age
* With Crohn's disease or ulcerative colitis
* Able to understand and answer the questions asked

Exclusion Criteria:

* Unable to understand and/or answer questions
* Not willing to participate in the study

Primary outcomes:
measure: GOHAI score
timeFrame: Baseline (One time only on the day of the consultation )
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: University Hospital, Lille
name: Kevimy AGOSSA
role: STUDY_CHAIR
References: