louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06843798: The Relationship Between Ergonomic Knowledge of Healthcare Professionals and Musculoskeletal Disorders
Official title: The Relationship Between Ergonomic Knowledge of Healthcare Professionals and Musculoskeletal Disorders
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Occupational Diseases
Lead sponsor: Uskudar University
Sponsor class: OTHER
First posted: 2025-02-25
Enrollment: 400
Sex: ALL
Minimum age (years): 25
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Healthcare workers

Brief summary: This study aims to investigate the relationship between the ergonomic awareness levels of Healthcare Workers and musculoskeletal disorders.

Detailed description: The present study is planned to be online. Personal information such as age, gender, and occupation will be collected from participants. Ergonomics information will be questioned. The Nordic musculoskeletal disorders questionnaire will be applied for the musculoskeletal disorders of the participants. Occupational burnout caused by musculoskeletal disorders will be investigated with the Maslach Burnout Scale. The degree to which musculoskeletal disorders affect sleep quality will be investigated with the Pittsburgh Sleep Quality Questionnaire.

Eligibility criteria: Inclusion Criteria:

* Being between 25 and 45 years old.
* Being a health worker
* Having at least 2 years of work experience

Exclusion Criteria:

* Participant having a musculoskeletal disorder before the study
* Having had surgery within 6 months
* Being pregnant
* Having a traumatic accident or injury that would affect the study

Primary outcomes:
measure: Maslach Burnout Scale
timeFrame: 1 week
measure: Nordic Musculoskeletal Questionnaire
timeFrame: 1 week
measure: The Pittsburgh Sleep Quality Index
timeFrame: 1 week
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Uskudar University
Study officials:
affiliation: Uskudar University
name: Mustafa ÇAĞIL
role: STUDY_CHAIR
References:
citation: Lietz J, Ulusoy N, Nienhaus A. Prevention of Musculoskeletal Diseases and Pain among Dental Professionals through Ergonomic Interventions: A Systematic Literature Review. Int J Environ Res Public Health. 2020 May 16;17(10):3482. doi: 10.3390/ijerph17103482.
citation: Jacquier-Bret J, Gorce P. Prevalence of Body Area Work-Related Musculoskeletal Disorders among Healthcare Professionals: A Systematic Review. Int J Environ Res Public Health. 2023 Jan 2;20(1):841. doi: 10.3390/ijerph20010841.
citation: Mansoor SN, Al Arabia DH, Rathore FA. Ergonomics and musculoskeletal disorders among health care professionals: Prevention is better than cure. J Pak Med Assoc. 2022 Jun;72(6):1243-1245. doi: 10.47391/JPMA.22-76.
Clinical trial NCT03416998: Photobiomodulation On Muscle Recovery In Professional Soccer Players
Official title: Effect Of Pre-Game Photobiomodulation On Muscle Recovery In Professional Soccer Players: Randomized, Cross-Over, Sham-Controlled, Triple-Blind, Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Muscle Development
Keywords: Photherapy
Photobiomodulation
Creatine Kinase
Soccer
Muscle Recovery
Lead sponsor: University of Nove de Julho
Sponsor class: OTHER
First posted: 2018-01-31
Enrollment: 30
Sex: MALE
Minimum age (years): 15
Maximum age (years): 20
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: Background: Photobiomodulation with low-level laser therapy (LLLT) has been widely used in clinical practice for diverse purposes, such as modulation of the inflammatory process, acceleration of the tissue repair process, pain relief and the enhancement of post-exercise recovery. Studies have demonstrated a beneficial interaction between photobiomodulation and the production of creatine kinase, with a reduction in the release of this marker of muscle damage when laser and/or LEDs is administered prior to high-intensity physical activity. The aim of the proposed study is to determine the influence of pre-exercise phototherapy on post-exercise muscle recovery.

Methods: A randomized, cross-over, sham-controlled, double-blind, clinical trial is proposed. The participants will be healthy professional soccer players aged 15 to 20 years from the same team with a body mass index within the ideal range (20 to 25 kg/m2) and no history of lower limb musculoskeletal injuries or surgery or back surgery in the previous six months. The athletes will be allocated to two groups based on the previously calculated sample size and will be blinded to allocation. Creatine kinase will be measured and the subjective perception of fatigue will be determined for each participant. The volunteers will then be randomly allocated to Group A, which will receive active phototherapy, and Group B, which will receive sham phototherapy. The athletes will undergo reevaluations immediately after as well as 48 hours after a football match. The data will be submitted to statistical analysis and the level of significance will be set to 5%.


Eligibility criteria: Inclusion Criteria:

* Healthy professional soccer players aged 15 to 20 years from the same team with a body mass index in the ideal range (20 to 25 kg/m2) will be included in the study.

Exclusion Criteria:

* A history of musculoskeletal injuries and/or surgeries in the lower limbs or back surgery in the previous six months

Primary outcomes:
measure: Muscle recovery
timeFrame: 30 Minutes
Secondary outcomes:
measure: Subjective muscle recovery
timeFrame: 30 Minutes
Other outcomes:
Locations:
city: São Paulo
country: Brazil
facility: University of Nove de Julho
Study officials:
References:
Clinical trial NCT01767298: Pharmacokinetic Interactions of Valsartan and Hydrochlorothiazide (Double Doses)
Official title: Pharmacokinetic Interactions of Valsartan and Hydrochlorothiazide: An Open-Label, Randomized, Four-Period Crossover Study in Healthy Egyptian Male Volunteers (PART II)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy Normotensive Participants
Keywords: Fixed dose combination
Pharmacokinetics
Valsartan
Hydrochlorothiazide
Lead sponsor: Damanhour University
Sponsor class: OTHER
First posted: 2013-01-14
Enrollment: 24
Sex: MALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER

Brief summary: This study was conducted to compare the rate and extent of absorption of valsartan and hydrochlorothiazide. To maximize the possibility of finding drug-drug interactions, the dose of valsartan and hydrochlorothiazide was doubled (320 mg of VAL and 25 mg of HCT).


Eligibility criteria: Inclusion Criteria:

* At least 18 years old and not more than 45 healthy male volunteers
* Actual weight no more than ± 30% from ideal body weight based on sex, height, and body frame
* Who had passed all the screening parameters
* Free of any drug exposure known to interfere with the pharmacokinetics or assay of fexofenadine for at least 10 days prior to the study
* Who had to be able to communicate effectively with study personnel, be literate, and able to give consent.

Exclusion Criteria:

* A clinically significant abnormal physical exam, medical history, or laboratory studies
* If they showed a sitting SBP of \>140 or \<100 mmHg, DBP \> 90 or \<60mm Hg, or a pulse rate of \> 95 or \< 50 beats/min at screening
* A history of serious intolerance, allergy, or sensitivity to fexofenadine
* The use of any prescription drug within the previous month or use of any over-the-counter medication (with the exception of acetaminophen) within the past 14 days
* A history of blood dyscrasias
* A history of alcohol or drug abuse within the past year
* Donation of blood during the 8 weeks prior to the study or plans to donate blood during or within 8 weeks of completing the study
* Unable to tolerate vein puncture and multiple blood samplings
* Any surgical/medical condition that might alter drug absorption, distribution, metabolism, or excretion
* Cannot follow instructions, in the opinion of the investigator.

Primary outcomes:
measure: Tolerability
timeFrame: Participants will be followed for the duration of study, an expected average of 6 weeks.
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01591798: Efficacy Study of Robotic Surgery for Rectal Cancer
Official title: Clinical Assessment of Laparoscopic and Robotic Surgery for Rectal Cancer - Randomized Phase II Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE2
Conditions: Rectal Neoplasm
Keywords: Rectal cancer
Robotic surgery
Laparoscopic surgery
Lead sponsor: National Cancer Center, Korea
Sponsor class: OTHER_GOV
First posted: 2012-05-04
Enrollment: 146
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: After introducing minimally invasive surgery, robotic surgery has been increasingly used in colorectal cancer. However, there is a few prospective study for robotic surgery. The aim of this trial is to evaluate the effectiveness and safety of robotic surgery in mid or low rectal cancer.

Detailed description: This study was designed as randomized phase II trial (laparoscopic versus robotic). The primary end point is quality of mesorectal excision.

Eligibility criteria: Inclusion Criteria:

* mid or low rectal cancer (within 9cm from anal verge)
* pathologically proven as adenocarcinoma
* written informed consent
* no severe functional disability in lung and heart

Exclusion Criteria:

* invading adjacent organ
* distant metastasis (lung, liver, brain, bone, distant lymph nodes etc.)
* lateral pelvic lymph node metastasis
* Have severe concomitant disease that might limit compliance or completion of the protocol.
* Have any other malignancy that might impact 5-year survival or might be potentially confused with rectal cancer.
* If female, be pregnant or breast feeding.
* Hereditary colorectal cancer (HNPCC, FAP etc)
* emergency operation

Primary outcomes:
measure: Quality of mesorectal excision
timeFrame: 7days after surgery (Pathologic report)
Secondary outcomes:
measure: Short-term postoperative outcome
timeFrame: Within postoperative 30 days
measure: Sexual and urinary function, Quality of life, Anorectal function
timeFrame: Baseline, postop 3 weeks, 3months, 12 months, 24 months, 36 months
measure: Long-term outcome
timeFrame: Postoperative 36 months
Other outcomes:
Locations:
city: Goyang
country: Korea, Republic of
facility: National Cancer Center
state: Gyeonggi
Study officials:
affiliation: National Cancer Center
name: Ji Won Park, Dr.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04440098: Isolated During COVID-19: Effects of COVID-19's Social Restrictions on Loneliness and Psychosocial Symptomatology
Official title: Isolated During COVID-19: Effects of COVID-19's Social Restrictions on Loneliness and Psychosocial Symptomatology
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Loneliness
Depression
Anxiety
Alcohol Abuse
Drug Abuse
Lead sponsor: University of Miami
Sponsor class: OTHER
First posted: 2020-06-19
Enrollment: 1008
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Community sample

Brief summary: This study seeks to gather data and insight on epidemiologic trends of loneliness and other behaviors in the wake of the CDC recommended "social distancing" during the COVID-19 pandemic. The objective of this study is to use a cross-sectional survey to assess the impact of COVID-19's associated recommendations (social distancing, self-isolation, and self-quarantine) on loneliness and psychosocial symptomatology (depression, anxiety, substance abuse) on young adults (18-35 years old).


Eligibility criteria: Inclusion Criteria

* 18-35 years old
* Currently living in the United States

Exclusion Criteria

* Those under 18 years, or older than 35 years
* Adults unable to consent
* Non-English-speaking adults

Primary outcomes:
measure: Loneliness as evaluated by the UCLA loneliness scale
timeFrame: Day 1
measure: Alcohol Use as evaluated by the AUDIT
timeFrame: Day 1
measure: Drug Use as evaluated by the DAST-10
timeFrame: Day 1
measure: Anxiety as evaluated by GAD-7
timeFrame: Day 1
measure: Depression as assessed by CES-D-10
timeFrame: Day 1
Secondary outcomes:
Other outcomes:
Locations:
city: Miami
country: United States
facility: University of Miami
state: Florida
Study officials:
affiliation: University of Miami
name: Viviana E Horigian, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Horigian VE, Schmidt RD, Feaster DJ. Loneliness, Mental Health, and Substance Use among US Young Adults during COVID-19. J Psychoactive Drugs. 2021 Jan-Mar;53(1):1-9. doi: 10.1080/02791072.2020.1836435. Epub 2020 Oct 28.
Clinical trial NCT04167098: Effectiveness of Platelet-rich Plasma for Treatment of Trigger Finger
Official title: A Prospective Randomized Placebo-controlled Trial Comparing Platelet-rich Plasma and Corticosteroid Injection for Treatment of Trigger Finger
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Tendon Entrapment
Keywords: Platelet-Rich Plasma
Trigger Finger
Lead sponsor: Töölö Hospital
Sponsor class: OTHER
First posted: 2019-11-18
Enrollment: 117
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Study purpose is to evaluate the effectiveness of Platelet-rich Plasma (PRP) injection in the treatment of trigger finger. We compare PRP to a corticosteroid (methylprednisolone) injection in a prospective randomized triple-blind placebo-controlled study.

Patients with clinically confirmed trigger finger are randomized (1:1:1 computer generated sequence with random block size) to three parallel groups and will receive an injection of either PRP, corticosteroid or placebo (0.9% saline) around the affected tendon sheath in a double-blind setting.

Baseline data is collected and is followed by a phone call at 1 month, and follow-up visits at 3, 6, 12 and 24 months after the intervention. Unveiling of the allocation is at 6 months post-intervention.

The primary outcome measures are:

* Symptom resolution
* Patient-Rated Wrist Evaluation

Secondary outcomes:

* Quick-Disabilities of the Arm, Shoulder and Hand
* Pain Visual Analogue Score
* Global improvement (7-step Likert-scale)
* Grip strength
* Finger range of motion


Eligibility criteria: Inclusion Criteria:

* Age 18 - 75
* Symptom duration \> 3 months

Exclusion Criteria:

* Diabetes
* Rheumatoid arthritis or other condition requiring continuous oral corticosteroids
* Previous history of surgery or injection to the affected ray
* Alcohol or drug abuse
* Mental instability

Primary outcomes:
measure: Symptom resolution
timeFrame: 24 months
measure: Patient-Rated Wrist Evaluation
timeFrame: 24 months
Secondary outcomes:
measure: Quick-Disabilities of the Arm, Shoulder and Hand
timeFrame: 24 months
measure: Pain (Visual Analogue Scale)
timeFrame: 24 months
measure: Global improvement
timeFrame: 24 months
measure: Grip strength
timeFrame: 24 months
measure: Finger range of motion (ROM)
timeFrame: 24 months
Other outcomes:
Locations:
city: Helsinki
country: Finland
facility: Töölö Hospital (Helsinki University Hospital)
Study officials:
References:
citation: Aspinen S, Nordback PH, Anttila T, Stjernberg-Salmela S, Ryhanen J, Kosola J. Platelet-rich plasma versus corticosteroid injection for treatment of trigger finger: study protocol for a prospective randomized triple-blind placebo-controlled trial. Trials. 2020 Nov 27;21(1):984. doi: 10.1186/s13063-020-04907-w.
Clinical trial NCT04771598: EVALUATING THE EFFICIENCY OF BREATHING EXERCISES PERFORMED BY POST-COVID TELEMEDICINE: Randomized Controlled Study
Official title: EVALUATING THE EFFICIENCY OF BREATHING EXERCISES PERFORMED BY POST-COVID TELEMEDICINE: Randomized Controlled Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Covid19
Lead sponsor: Tokat Gaziosmanpasa University
Sponsor class: OTHER
First posted: 2021-02-25
Enrollment: 52
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomised Controlled Study
Primary purpose: SUPPORTIVE_CARE

Brief summary: As an important non-drug intervention in the treatment of respiratory tract diseases, respiratory rehabilitation training is increasingly accepted in clinical practice. The purpose of pulmonary rehabilitation is not only to improve the physical and mental conditions of the patient, but also to help the patient return to the family and society more quickly.

In light of the widely documented lung injuries associated with COVID-19, concerns are raised regarding the assessment of lung injury in discharged patients. As an important non-drug intervention in the treatment of respiratory diseases, respiratory rehabilitation training is increasingly being accepted in clinical practice The purpose of pulmonary rehabilitation is not only to improve the physical and mental conditions of the patient, but also to help the patient return to the family and society more quickly.

The aim of the study; It is aimed to evaluate the efficiency of breathing exercise in individuals with COVID-19.


Eligibility criteria: Inclusion Criteria:

* 18 years of age or older and who received / will receive treatment with the diagnosis of COVID 19 and completed 2 months after the diagnosis of COVID 19
* Patients who applied to the Pulmonary Diseases outpatient clinic with complaints of dyspnea
* FEV1 / FVC \<80%, FVC \<80%, FEV1 \<80%, FEF25-75\> 50% and / or Patients with respiratory distress in daily living activities

Exclusion Criteria:

* FEV 1 \<50%, FEF 25-75 \<50% detected oxygen saturation \<85% at rest,
* moderately severe heart failure,
* has a disease that restricts its mobilization,
* psychiatric illness,
* advanced stage liver, advanced stage renal failure,
* Myocardial infarction within 4 months
* having a history of unstable angina
* active infectious disease

Primary outcomes:
measure: 6 minute walking test
timeFrame: 1 month
measure: FEV-1
timeFrame: 1 month
measure: FVC
timeFrame: 1 month
measure: FEV1/FVC
timeFrame: 1 month
measure: MVV
timeFrame: 1 month
Secondary outcomes:
measure: St. George's Respiratory Questionnaire
timeFrame: 1 month
Other outcomes:
Locations:
city: Tokat
country: Turkey
facility: Tokat State Hospital
Study officials:
References:
Clinical trial NCT03842098: Korean Medicine Patient Registry of Postoperative Therapy for Musculoskeletal Disorders (KPOP-MD): A Study Protocol
Official title: Korean Medicine Patient Registry of Postoperative Therapy for Musculoskeletal Disorders (KPOP-MD): A Study Protocol
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Musculoskeletal Disorders
Korean Medicine Patient Registry
Post-operative Therapy
Keywords: Korean Medicine Patient Registry
Post-operative Therapy
Musculoskeletal Disorders
Lead sponsor: Gachon University Gil Oriental Medical Hospital
Sponsor class: OTHER
Collaborators: name: Kyunghee University Medical Center
name: CHUNG YEON Korean Medicine Hospital
name: Korean medicine hospital of Daejeon University
name: Wonkwang University Iksan Korean Medicine Hospital
First posted: 2019-02-15
Enrollment: 150
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients who suffers from various symptoms after musculoskeletal surgeries

Brief summary: To create an infrastructure that allows for the conduct of prospective, controlled studies comparing the effectiveness of diagnostic and treatment strategies for patients with musculoskeletal disorders after musculoskeletal operations


Eligibility criteria: Inclusion Criteria:

* aged 19 and over
* Those who have undergone musculoskeletal related surgery (corresponding to the disease classification code M00-99, S00-99) within 3 years
* voluntary applicant who has no problem with communicate with study associates or a mild cognitive impairment patient who scored higher than 23 points in Korean version of the montreal rating questionnaire with voluntary participation

Exclusion Criteria:

* Participants in other clinical trials
* Those who are unlikely to be adhered to the schedule of clinical studies
* Those who are expected to have difficulty understanding and responding to research questionnaires such as illiteracy, mental and physical weakness

Primary outcomes:
measure: Change in musculoskeletal pain intensity
timeFrame: At baseline, enrollment after 3/6/9/12 months
measure: Change in Disability and estimating quality of life
timeFrame: At baseline, enrollment after 3/6/9/12 months
measure: Change in reduction of pain severity by K-WOMAC
timeFrame: At baseline, enrollment after 3/6/9/12 months
measure: Change in Pain and disability of the shoulder by SPADI questionnaire
timeFrame: At baseline, enrollment after 3/6/9/12 months
measure: Change in current health status
timeFrame: At baseline, enrollment after 3/6/9/12 months
measure: Change in Severity assessment of any symptoms other than pain
timeFrame: At baseline, enrollment after 3/6/9/12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Incheon
country: Korea, Republic of
facility: Gachon universiry affiliated Gil oriental medicine hospital
Study officials:
affiliation: Gachon University Gil Oriental Medical Hospital
name: Yun-Kyung Song, PhD
role: PRINCIPAL_INVESTIGATOR
References: