Clinical trial NCT04078737: Clopidogrel With Aspirin in High-risk Patients With Acute Non-disabling Cerebrovascular Events II
Official title: Clopidogrel With Aspirin in High-risk Patients With Acute Non-disabling Cerebrovascular Events II
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Stroke
Transient Ischemic Attack
Keywords: stroke
transient ischemic attack
acute treatment
acute non-disabling cerebrovascular event
clopidogrel
ticagrelor
clopidogrel combined with ASA
ticagrelor combined with ASA
recurrence of stroke and other vascular events
CYP2C19 loss-of-function allele(s) carrier
Lead sponsor: Beijing Tiantan Hospital
Sponsor class: OTHER
Collaborators: name: Ministry of Science and Technology of the People´s Republic of China
First posted: 2019-09-06
Enrollment: 6412
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The primary objective of this trial is to assess the effects of ticagrelor plus aspirin versus clopidogrel plus aspirin on reducing the 3-month risk of any stroke (both ischemic and hemorrhagic, primary outcome) when initiated within 24 hours of symptom onset in CYP2Y19 LOF alleles carriers with TIA or minor stroke.

Detailed description: According to the Global Burden of Disease(GBD) Study 2016, China bears the greatest lifetime risk of stroke from 25-year-age onward. Minor ischemic events, including minor stroke and TIA, were major parts of stroke manifestations. Events (CHANCE) has shown that 21-day dual antiplatelet therapy (clopidogrel and aspirin) compared to aspirin alone which initiated within 24 hours after symptoms onset would reduce 32% risk of stroke recurrence within 90 day, but not in carriers of CYP2C19 loss-of-function (LOF) alleles. The primary purpose of this study is to compare ticagrelor plus aspirin with clopidogrel plus aspirin on reducing the 3-month risk of any stroke (both ischemic and hemorrhagic, primary outcome) when initiated within 24 hours of symptom onset in CYP2Y19 LOF alleles carriers with TIA or minor stroke.

Both intent analysis (ITT) and compliance program set (PPS) were used for analysis.

We will use Kaplan-Meier estimates of the cumulative risk of stroke (ischemic or hemorrhagic) event during maximum 90-day follow-up, with hazards ratios and 95% CI calculated using Cox proportional hazards methods and the log-rank test to evaluate the treatment effect. All statistics will be 2-sided with P\<0.05 considered significant, accounting for interim analyses.

All patients who received study drugs and with at least one safety follow-up record will be included in the safety population. The data for safety evaluation included adverse reactions observed during the trial and changes in laboratory data before and after treatment.

Eligibility criteria: Inclusion Criteria

1. 40 years or older than 40 years；
2. Acute cerebral ischemic event due to：

   * Acute non-disabling ischemic stroke (NIHSS≤3 at the time of randomization)or，
   * TIA with moderate-to-high risk of stroke (ABCD2 score ≥ 4 at the time of randomization)；
3. Can be treated with study drug within 24 hours of symptoms onset\*(\*Symptom onset is defined by the "last seen normal" principle)；
4. CYP2C19 loss-of-function allele carriers；
5. Informed consent signed.

Exclusion Criteria

1. Malformation, tumor, abscess or other major non-ischemic brain disease (e.g., multiple sclerosis) on baseline head CT or MRI.
2. Isolated or pure sensory symptoms (e.g., numbness), isolated visual changes, or isolated dizziness/vertigo without evidence of acute infarction on baseline head CT or MRI.
3. Iatrogenic causes (angioplasty or surgery) of minor stroke or TIA.
4. Preceding moderate or severe dependency (modified Rankin scale \[mRS\] score 3-5).
5. Contraindication to clopidogrel, ticagrelor or aspirin

   * Known allergy
   * Severe renal (creatinine exceeding 1.5 times of the upper limit of normal range) or hepatic (ALT or AST \> twice the upper limit of normal range) insufficiency
   * Severe cardiac failure (NYHA level: III to IV)
   * History of hemostatic disorder or systemic bleeding
   * History of thrombocytopenia or neutropenia
   * History of drug-induced hematologic disorder or hepatic dysfunction
   * Low white blood cell (\<2×109/L) or platelet count (\<100×109/L)
6. Hematocrit (HCT) \<30%
7. Clear indication for anticoagulation (presumed cardiac source of embolus, e.g., atrial fibrillation, prosthetic cardiac valves known or suspected endocarditis)
8. History of intracranial hemorrhage or amyloid angiopathy
9. History of aneurysm (including intracranial aneurysm and peripheral aneurysm)
10. History of asthma or COPD (chronic obstructive pulmonary disease)
11. High-risk for bradyarrhythmia (first-degree or second-degree AV block caused by sinus node disease, and brady-arrhythmic syncope without pacemaker)
12. History of hyperuricemia nephropathy
13. Anticipated requirement for long-term (\>7 days) non-steroidal anti-inflammatory drugs (NSAIDs)
14. Planned or likely revascularization (any angioplasty or vascular surgery) within the next 3 months
15. Scheduled for surgery or interventional treatment requiring study drug cessation
16. Severe non-cardiovascular comorbidity with life expectancy \< 3 months
17. Inability to understand and/or follow research procedures due to mental, cognitive, or emotional disorders
18. Dual antiplatelet treatment (or more than two antiplatelet agents) in 72 hours before randomization
19. Current treatment (last dose given within 10 days before randomization) with heparin therapy or oral anti coagulation
20. Intravenous thrombolytic therapy (such as intravenous rtPA) or mechanical thrombectomy within 24 hours prior to randomization
21. Gastrointestinal bleed within 3 months or major surgery within 30 days
22. Diagnosis or suspicious diagnosis of acute coronary syndrome
23. Participation in another clinical study with an experimental product during the last 30 days
24. Currently receiving an experimental drug or device
25. Pregnant, currently trying to become pregnant, or of child-bearing potential and not using birth control

Primary outcomes:
measure: Any new stroke events (ischemic stroke or hemorrhagic stroke) within 3 months
timeFrame: 3 months after randomization
Secondary outcomes:
measure: Any new stroke events within 30 days and 1 year
timeFrame: 30 days and 1 year after randomization
measure: New clinical vascular events including stroke, TIA, myocardial infarction, and vascular deaths within 3 months and 1 year
timeFrame: 3 months and 1 year after randomization
measure: New ischemic stroke within 3 months and 1 year
timeFrame: 3 months and 1 year after randomization
measure: Disabling stroke (Modified Rankin Scale score, mRS>1) at 3 months and 1 year
timeFrame: 3 months and 1 year after randomization
measure: Incidence and severity of recurrent stroke and TIA during follow-up to 3 months and 1-year
timeFrame: 3 months and 1 year after randomization
measure: Neurological impairment at 3 months (NIHSS increased≥4 from baseline)
timeFrame: 3 months after randomization
measure: Quality of Life (EuroQol EQ-5D scale) at 3 months and at 1 year
timeFrame: 3 months and 1 year after randomization
measure: Stratified analysis
timeFrame: 3 months and 1 year after randomization
Other outcomes:
measure: Moderate and severe bleeding events according to the GUSTO criteria
timeFrame: 3 months after randomization
measure: Moderate and severe bleeding events according to the GUSTO criteria
timeFrame: 1 year after randomization
measure: All bleeding events
timeFrame: 3 months and 1 year after randomization
measure: Total mortality
timeFrame: 3 months and 1 year after randomization
measure: Incidence symptomatic intracranial hemorrhagic events
timeFrame: 3 months and 1 year after randomization
measure: Adverse events
timeFrame: 3 months and 1 year after randomization
Locations:
city: Anqing
country: China
facility: Anqing Municipal Hospital
state: Anhui
city: Bengbu
country: China
facility: The First Affiliated Hospital of Bengbu Medical College
state: Anhui
city: Beijing
country: China
facility: Beijing Chaoyang Hospital, Capital MedicalUniversity（west Hospital）
state: Beijing
city: Beijing
country: China
facility: Beijing Tian tan Hospital
state: Beijing
city: Beijing
country: China
facility: Beijing Shunyi Airport Hospital
state: Beijing
city: Beijing
country: China
facility: The First Hospital of Fangshan District
state: Beijing
city: Beijing
country: China
facility: Beijing Coal Group Hospital
state: Beijing
city: Beijing
country: China
facility: Peking University Third Hospital
state: Beijing
city: Chongqing
country: China
facility: Chongqing People's Hospital
state: Chongqing
city: Chongqing
country: China
facility: The Second Affiliated Hospital of Chongqing Medical University
state: Chongqing
city: Chongqing
country: China
facility: Chongqing Sanbo Chang 'an Hospital
state: Chongqing
city: Chongqing
country: China
facility: Daping Hospital of Army Military Medical University
state: Chongqing
city: Chongqing
country: China
facility: The First Affiliated Hospital of Chongqing Medical University
state: Chongqing
city: Chongqing
country: China
facility: Chongqing Fifth People's Hospital
state: Chongqing
city: Chongqing
country: China
facility: The Third Affiliated Hospital of Chongqing Medical University
state: Chongqing
city: Chongqing
country: China
facility: People's Hospital of Rongchang District, Chongqing,
state: Chongqing
city: Chongqing
country: China
facility: Chongqing Three Gorges Central Hospital
state: Chongqing
city: Chongqing
country: China
facility: Chongqing Kaizhou District People's Hospital
state: Chongqing
city: Chongqing
country: China
facility: Chongqing Fuling Central Hospital
state: Chongqing
city: Chongqing
country: China
facility: Chongqing Nanchuan District People's Hospital
state: Chongqing
city: Chongqing
country: China
facility: Xiushan Tujia and Miao Autonomous County People's Hospital
state: Chongqing
city: Fuzhou
country: China
facility: The Third Affiliated Hospital of Fujian University of Traditional Chinese Medicine
state: Fujian
city: Fuzhou
country: China
facility: Fuzhou Second Hospital
state: Fujian
city: Sanming
country: China
facility: Sanming First Hospital Affiliated to Fujian Medical University
state: Fujian
city: Wuwei
country: China
facility: Wuwei People's Hospital
state: Gansu
city: Zhangye
country: China
facility: Zhangye People's Hospital Affiliated to Hexi College
state: Gansu
city: Dongguan
country: China
facility: Dongguan People's Hospital
state: Guangdong
city: Guangzhou
country: China
facility: The Second Affiliated Hospital of Guangzhou Medical University
state: Guangdong
city: Guangzhou
country: China
facility: Nanfang Hospital Of Southern Medical University
state: Guangdong
city: Guangzhou
country: China
facility: The First Affiliated Hospital of Jinan University
state: Guangdong
city: Shantou
country: China
facility: The first Affiliated Hospital of Shantou University Medical College
state: Guangdong
city: Guiyang
country: China
facility: Guiyang Second People's Hospital
state: Guizhou
city: Guiyang
country: China
facility: Affiliated Hospital of Guizhou Medical University
state: Guizhou
city: Danzhou
country: China
facility: Hainan West Central Hospital
state: Hainan
city: Haikou
country: China
facility: The First Affiliated Hospital of Hainan Medical University
state: Hainan
city: Baoding
country: China
facility: Affiliated Hospital of Hebei Medical University
state: Hebei
city: Baoding
country: China
facility: Affiliated Hospital of Hebei University
state: Hebei
city: Chengde
country: China
facility: The Affiliated Hospital of Chengde Medical College
state: Hebei
city: Hejian
country: China
facility: Hejian People's Hospital
state: Hebei
city: Hengshui
country: China
facility: HaLixun InternationalPeace Hospital
state: Hebei
city: Hengshui
country: China
facility: Hengshui fourth People Hospital（Department of Neurology ward 2）
state: Hebei
city: Hengshui
country: China
facility: The Fourth People's Hospital of Hengshui City（Department of Neurology ward 1）
state: Hebei
city: Shijiazhuang
country: China
facility: The Second Hospitalof Hebei Medical University
state: Hebei
city: Zhangjiakou
country: China
facility: The First Affiliated Hospital of Hebei North University
state: Hebei
city: Zhuozhou
country: China
facility: Second Central Hospital of Baoding
state: Hebei
city: Daqing
country: China
facility: Daqing Oilfield Gengeal Hospital
state: Heilongjiang
city: Daqing
country: China
facility: Daqing People's Hospital
state: Heilongjiang
city: Harbin
country: China
facility: The First Hospital of Harbin Medical University
state: Heilongjiang
city: Harbin
country: China
facility: The Second Hospital of Harbin Medical University（Department of Neurology ward 1）
state: Heilongjiang
city: Harbin
country: China
facility: The Second Hospital of Harbin Medical University（Department of Neurology ward ）
state: Heilongjiang
city: Jiamusi
country: China
facility: The First Affiliated Hospital of Jiamusi University
state: Heilongjiang
city: Mudanjiang
country: China
facility: Hongqi Hospital affiliated to Mudanjiang Medical University
state: Heilongjiang
city: Qiqihar
country: China
facility: Qiqihar Rongjian Institute of Stroke Prevention and Treatment
state: Heilongjiang
city: Anyang
country: China
facility: Anyang People's Hospital
state: Henan
city: Changge
country: China
facility: Changge People's Hospital
state: Henan
city: Jiaozuo
country: China
facility: Xiuwu County People's Hospital
state: Henan
city: Jiyuan
country: China
facility: Jiyuan People's Hospital
state: Henan
city: Kaifeng
country: China
facility: Kaifeng Central Hospital
state: Henan
city: Kaifeng
country: China
facility: weishi county Central Hospital
state: Henan
city: Luohe
country: China
facility: Luohe Central Hospital
state: Henan
city: Luoyang
country: China
facility: Luoyang Central Hospital
state: Henan
city: Luoyang
country: China
facility: The first Affiliated Hospital of Henan University of Science and Technology
state: Henan
city: Luoyang
country: China
facility: The Second Affiliated Hospital of Henan University of Science and Technology
state: Henan
city: Luoyang
country: China
facility: Luoyang New District People's Hospital
state: Henan
city: Pingdingshan
country: China
facility: Pingdingshan First People's Hospital
state: Henan
city: Sanmenxia
country: China
facility: Sanmenxia Central Hospital
state: Henan
city: Shangqiu
country: China
facility: Shangqiu Fourth People's Hospital
state: Henan
city: Shangqiu
country: China
facility: Suixian county Hospital of Traditional Chinese Medicine
state: Henan
city: Xingyang
country: China
facility: Xingyang People's Hospital
state: Henan
city: Xinxiang
country: China
facility: The first Affiliated Hospital of Xinxiang Medical University
state: Henan
city: Zhengzhou
country: China
facility: The First Affiliated Hospital of Henan University of Traditional Chinese Medicine
state: Henan
city: Zhengzhou
country: China
facility: Gongyi People's Hospital
state: Henan
city: Zhoukou
country: China
facility: Zhoukou Yongshan Hospital
state: Henan
city: Zhumadian
country: China
facility: Zhumadian Hospital of Traditional Chinese Medicine
state: Henan
city: Wuhan
country: China
facility: Wuhan No.1 Hospital
state: Hubei
city: Wuhan
country: China
facility: The Central Hospital of Wuhan
state: Hubei
city: Changsha
country: China
facility: First hospital of Changsha city
state: Hunan
city: Chenzhou
country: China
facility: Chenzhou First People's Hospital
state: Hunan
city: Chenzhou
country: China
facility: Fourth People's Hospital of Chenzhou
state: Hunan
city: Hengyang
country: China
facility: The First Affiliated Hospital of Nanhua University
state: Hunan
city: Loudi
country: China
facility: Loudi City Central Hospital
state: Hunan
city: Shaoyang
country: China
facility: shaoyang Central Hospital
state: Hunan
city: Xiangtan
country: China
facility: Xiangtan Central Hospital
state: Hunan
city: Yueyang
country: China
facility: Yueyang Second People's Hospital
state: Hunan
city: Baotou
country: China
facility: The first Affiliated Hospital of Baotou Medical College
state: Inner Mongolia Autonomous Region
city: Baotou
country: China
facility: Baotou CentralHospital
state: Inner Mongolia Autonomous Region
city: Baotou
country: China
facility: The second Affiliated Hospital of Baotou Medical College
state: Inner Mongolia Autonomous Region
city: Bayan Nur
country: China
facility: Wuyuan County People's Hospital
state: Inner Mongolia Autonomous Region
city: Buri
country: China
facility: Hulun Buir People's Hospital
state: Inner Mongolia Autonomous Region
city: Chifeng
country: China
facility: Chifeng City Hospital
state: Inner Mongolia Autonomous Region
city: Chifeng
country: China
facility: Affiliated Hospital of Chifeng University
state: Inner Mongolia Autonomous Region
city: Hohhot
country: China
facility: Inner Mongolia People's Hospital
state: Inner Mongolia Autonomous Region
city: Hohhot
country: China
facility: Inner Mongolia International Mongolian Hospital
state: Inner Mongolia Autonomous Region
city: Shangrao
country: China
facility: Shangrao City People's Hospital
state: Jiang XI
city: Huai'an
country: China
facility: Huaian Hospital of Traditional Chinese Medicine
state: Jiangsu
city: Huai'an
country: China
facility: Lianshui County People's Hospital
state: Jiangsu
city: Lianyungang
country: China
facility: The Second People's Hospital of Lianyungang
state: Jiangsu
city: Nanjing
country: China
facility: Nanjing Jiangning Hospital
state: Jiangsu
city: Nanjing
country: China
facility: The Second Affiliated Hospital of Nanjing Medical University
state: Jiangsu
city: Nanjing
country: China
facility: Nanjing Gulou Hospital
state: Jiangsu
city: Nanjing
country: China
facility: BenQ Hospital affiliated to Nanjing Medical University
state: Jiangsu
city: Nanjing
country: China
facility: Jiangsu Provincial Hospital of Traditional Chinese Medicine
state: Jiangsu
city: Nanjing
country: China
facility: Nanjing Brain Hospital
state: Jiangsu
city: Nanjing
country: China
facility: The Fourth Affiliated Hospital of Nanjing Medical University
state: Jiangsu
city: Nanjing
country: China
facility: Nanjing Jiangbei People's Hospital
state: Jiangsu
city: Nanjing
country: China
facility: Nanjing Gaochun People's Hospital
state: Jiangsu
city: Nantong
country: China
facility: Nantong 6th People's Hospital
state: Jiangsu
city: Nantong
country: China
facility: Nantong Hospital of Traditional Chinese Medicine
state: Jiangsu
city: Nantong
country: China
facility: The Third People's Hospital in Tongzhou District, Nantong
state: Jiangsu
city: Nantong
country: China
facility: Affiliated Hospital of Nantong University
state: Jiangsu
city: Nantong
country: China
facility: Nantong First People's Hospital
state: Jiangsu
city: Nantong
country: China
facility: Nantong Second People's Hospital
state: Jiangsu
city: Nantong
country: China
facility: Nantong Fourth People's Hospital
state: Jiangsu
city: Nantong
country: China
facility: Nantong Third People's Hospital
state: Jiangsu
city: Nantong
country: China
facility: Tongzhou District People's Hospital of Nantong City
state: Jiangsu
city: Nantong
country: China
facility: Rudong County People's Hospital
state: Jiangsu
city: Nantong
country: China
facility: Rugao People's Hospital
state: Jiangsu
city: Nantong
country: China
facility: Hai 'an People's Hospital
state: Jiangsu
city: Nantong
country: China
facility: Tongzhou District 8th People's Hospital of Nantong City
state: Jiangsu
city: Suqian
country: China
facility: Siyang County People's Hospital
state: Jiangsu
city: Suqian
country: China
facility: Siyang Kangda Hospital
state: Jiangsu
city: Suqian
country: China
facility: Suqian People's Hospital
state: Jiangsu
city: Suzhou
country: China
facility: Suzhou Municipal Hospital
state: Jiangsu
city: Suzhou
country: China
facility: The Second Affiliated Hospital of Soochow University
state: Jiangsu
city: Taizhou
country: China
facility: Taizhou People's Hospital
state: Jiangsu
city: Taizhou
country: China
facility: Xinghua People's Hospital
state: Jiangsu
city: Wuxi
country: China
facility: Wuxi People's Hospital
state: Jiangsu
city: Wuxi
country: China
facility: Affiliated Hospital of Jiangnan University
state: Jiangsu
city: Wuxi
country: China
facility: Yixing People's Hospital
state: Jiangsu
city: Wuxi
country: China
facility: Jiangyin People's Hospital
state: Jiangsu
city: Xuzhou
country: China
facility: xuzhou Central Hospital
state: Jiangsu
city: Xuzhou
country: China
facility: Xuzhou coal mining group General Hospital
state: Jiangsu
city: Xuzhou
country: China
facility: Affiliated Hospital of Xuzhou Medical University（Department of Neurology ward 1）
state: Jiangsu
city: Xuzhou
country: China
facility: Affiliated Hospital of Xuzhou Medical University（Department of Neurology ward 2）
state: Jiangsu
city: Yangzhou
country: China
facility: Subei People's Hospital of Jiangsu province
state: Jiangsu
city: Yangzhou
country: China
facility: Affiliated Hospital of Yangzhou University
state: Jiangsu
city: Zhenjiang
country: China
facility: The fourth peoples hospital of zhenjiang city
state: Jiangsu
city: Ganzhou
country: China
facility: Ganzhou city people's Hospital
state: Jiangxi
city: Jingdezhen
country: China
facility: The First People's Hospital of Jingdehzne City
state: Jiangxi
city: Jiujiang
country: China
facility: Affiliated Hospital of Jiujiang College
state: Jiangxi
city: Jiujiang
country: China
facility: Jiujiang first people's Hospital
state: Jiangxi
city: Nanchang
country: China
facility: First Affiliated Hospital of Nanchang University
state: Jiangxi
city: Nanchang
country: China
facility: Jiangxi Provincial People's Hospital
state: Jiangxi
city: Changchun
country: China
facility: Sino-Japanese Friendship Hospital Of Jilin University
state: Jilin
city: Changchun
country: China
facility: The First Hospital Of Jilin University
state: Jilin
city: Changchun
country: China
facility: Jilin Provincial People's Hospital
state: Jilin
city: Dalian
country: China
facility: Xinhua Hospital affiliated to Dalian University
state: Liaoning
city: Huludao
country: China
facility: Second People's Hospital of Huludao City
state: Liaoning
city: Shenyang
country: China
facility: Shengjing Hospital of China Medical University
state: Liaoning
city: Shenyang
country: China
facility: First People's Hospital of Shenyang
state: Liaoning
city: Guyuan
country: China
facility: Guyuan people's hospital
state: Ningxia Hui Autonomous Region
city: Shizuishan
country: China
facility: The Fifth People's Hospital of Ningxia Hui Autonomous Region
state: Ningxia Hui Autonomous Region
city: Shizuishan
country: China
facility: The Second People's Hospital of Shizuishan
state: Ningxia Hui Autonomous Region
city: Shizuishan
country: China
facility: Shizuishan First People's Hospital
state: Ningxia Hui Autonomous Region
city: Shizuishan
country: China
facility: Second people's Hospital of shizuishan
state: Ningxia Hui Autonomous Region
city: Yinchuan
country: China
facility: General Hospital of Ningxia Medical University
state: Ningxia Hui Autonomous Region
city: Yinchuan
country: China
facility: Yinchuan First People's Hospital
state: Ningxia Hui Autonomous Region
city: Yinchuan
country: China
facility: Cardiovascular and Cerebrovoscular Hospital of General Hospital of Ningxia Med. Univ
state: Ningxia Hui Autonomous Region
city: Yinchuan
country: China
facility: People's Hospital of Ningxia Hui Autonomous Region
state: Ningxia Hui Autonomous Region
city: Zhongwei
country: China
facility: Zhongwei People's Hospital
state: Ningxia Hui Autonomous Region
city: Baoji
country: China
facility: Baoji High-tech People's Hospital
state: Shaanxi
city: Weinan
country: China
facility: weinan Central Hospital
state: Shaanxi
city: Xi'an
country: China
facility: Xi 'an Hi-tech Hospital
state: Shaanxi
city: Xi'an
country: China
facility: Xi 'an Fengcheng Hospital
state: Shaanxi
city: Xi'an
country: China
facility: Xian 141 Hospital
state: Shaanxi
city: Dezhou
country: China
facility: Dezhou People's Hospital
state: Shandong
city: Dezhou
country: China
facility: Ningjin County People's Hospital
state: Shandong
city: Jinan
country: China
facility: Shandong Provincial Hospital
state: Shandong
city: Liaocheng
country: China
facility: Liaocheng City Third People's Hospital
state: Shandong
city: Liaocheng
country: China
facility: Liaocheng People's Hospital
state: Shandong
city: Liaocheng
country: China
facility: Liaocheng Veterans Hospital
state: Shandong
city: Liaocheng
country: China
facility: The Brain Hospital of Liaocheng People's Hospital
state: Shandong
city: LiaoCheng
country: China
facility: Guanxian People's Hospital
state: Shandong
city: Liaocheng
country: China
facility: Liaocheng City Second People's Hospital
state: Shandong
city: Liaocheng
country: China
facility: Dongchangfu people's Hospital
state: Shandong
city: Liaocheng
country: China
facility: Liaocheng Central Hospital
state: Shandong
city: Linqing
country: China
facility: Linqing People's Hospital
state: Shandong
city: Qingdao
country: China
facility: Qingdao Municipal Hospital
state: Shandong
city: Qingdao
country: China
facility: Affiliated Hospital of Qingdao University Medical College
state: Shandong
city: Qingdao
country: China
facility: Qingdao West Coast New Area People's Hospital
state: Shandong
city: Weifang
country: China
facility: Affiliated Hospital of Weifang Medical University
state: Shandong
city: Weifang
country: China
facility: Sunshine Union Hospital
state: Shandong
city: Weihai
country: China
facility: weihai Central Hospital
state: Shandong
city: Weihai
country: China
facility: Wendeng District People's Hospital
state: Shandong
city: Yantai
country: China
facility: Penglai People's Hospital
state: Shandong
city: Yantai
country: China
facility: Yantai Beihai Hospita
state: Shandong
city: Shanghai
country: China
facility: Putuo District Central Hospital
state: Shanghai
city: Shanghai
country: China
facility: Shanghai 7th People's Hospital
state: Shanghai
city: Changzhi
country: China
facility: Changzhi People's Hospital
state: Shanxi
city: Changzhi
country: China
facility: Heping Hospital affiliated to Changzhi Medical College
state: Shanxi
city: Datong
country: China
facility: Datong Fifth People's Hospital
state: Shanxi
city: Datong
country: China
facility: The Third People's Hospital of Datong
state: Shanxi
city: Taiyuan
country: China
facility: Shanxi cardiovascular disease hospital
state: Shanxi
city: Taiyuan
country: China
facility: Shanxi Bethune Hospital
state: Shanxi
city: Taiyuan
country: China
facility: Taiyuan Iron and Steel (Group) Co, Ltd,General Hospital
state: Shanxi
city: Taiyuan
country: China
facility: The First Hospital of Shanxi Medical University
state: Shanxi
city: Xi'an
country: China
facility: Xi 'an First Hospital
state: Shanxi
city: Shenzhen
country: China
facility: Shenzhen Integrated Chinese and Western Medicine Hospital
state: Shenzhen
city: Shenzhen
country: China
facility: Shenzhen Luohu People's Hospital
state: Shenzhen
city: Shenzhen
country: China
facility: Shenzhen Second People's Hospital
state: Shenzhen
city: Shenzhen
country: China
facility: Huazhong University of Science and Technology Union Shenzhen Hospital
state: Shenzhen
city: Chengdou
country: China
facility: West China Hospital Of Sichuan University
state: Sichuan
city: Chengdu
country: China
facility: Chengdu second Municipal People'sHospital
state: Sichuan
city: Chengdu
country: China
facility: Sichuan Provincial People's Hospital
state: Sichuan
city: Dazhou
country: China
facility: dazhou Central Hospital
state: Sichuan
city: Tianjin
country: China
facility: Tianjin Medical University General Hospital
state: Tianjin
city: Guiyang
country: China
facility: First Affiliated Hospital of Xinjiang Medical University
state: Xinjiang Autonomous Region
city: Urumqi
country: China
facility: People's Hospital Of Xinjiang Uygur Autonomous Region
state: Xinjiang Autonomous Region
city: Yining
country: China
facility: Friendship Hospital of Ili Kazak Autonomous Prefecture
state: Xinjiang Autonomous Region
city: Kunming
country: China
facility: First People's Hospital of Yunnan Province
state: Yunnan
city: Hangzhou
country: China
facility: Hangzhou first people's Hospital
state: Zhejiang
city: Lishui
country: China
facility: lishui municipal Central Hospital
state: Zhejiang
city: Ruian
country: China
facility: Zhejiang Wenzhou Medical College Third Affiliated Hospital
state: Zhejiang
city: Taizhou
country: China
facility: Taizhou First People's Hospital
state: Zhejiang
Study officials:
affiliation: Beijing Tian Tan Hospital, Capital Medical University, Beijing, China
name: Yongjun Wang, M.D
role: PRINCIPAL_INVESTIGATOR
References:
citation: Wang A, Xie X, Tian X, Johnston SC, Li H, Bath PM, Zuo Y, Jing J, Lin J, Wang Y, Zhao X, Li Z, Jiang Y, Liu L, Meng X, Wang Y. Ticagrelor-Aspirin Versus Clopidogrel-Aspirin Among CYP2C19 Loss-of-Function Carriers With Minor Stroke or Transient Ischemic Attack in Relation to Renal Function: A Post Hoc Analysis of the CHANCE-2 Trial. Ann Intern Med. 2022 Nov;175(11):1534-1542. doi: 10.7326/M22-1667. Epub 2022 Nov 1.
citation: Wang A, Meng X, Tian X, Johnston SC, Li H, Bath PM, Zuo Y, Xie X, Jing J, Lin J, Wang Y, Zhao X, Li Z, Jiang Y, Liu L, Wang F, Wang Y, Huang P, Chen G, Wang Y; CHANCE-2 Investigators. Effect of Hypertension on Efficacy and Safety of Ticagrelor-Aspirin Versus Clopidogrel-Aspirin in Minor Stroke or Transient Ischemic Attack. Stroke. 2022 Sep;53(9):2799-2808. doi: 10.1161/STROKEAHA.122.038662. Epub 2022 Jun 3.
citation: Wang Y, Meng X, Wang A, Xie X, Pan Y, Johnston SC, Li H, Bath PM, Dong Q, Xu A, Jing J, Lin J, Niu S, Wang Y, Zhao X, Li Z, Jiang Y, Li W, Liu L, Xu J, Chang L, Wang L, Zhuang X, Zhao J, Feng Y, Man H, Li G, Wang B; CHANCE-2 Investigators. Ticagrelor versus Clopidogrel in CYP2C19 Loss-of-Function Carriers with Stroke or TIA. N Engl J Med. 2021 Dec 30;385(27):2520-2530. doi: 10.1056/NEJMoa2111749. Epub 2021 Oct 28.
citation: Wang Y, Johnston C, Bath PM, Meng X, Jing J, Xie X, Wang A, Pan Y, Xu A, Dong Q, Wang Y, Zhao X, Li Z, Li H; CHANCE-2 Investigators. Clopidogrel with aspirin in High-risk patients with Acute Non-disabling Cerebrovascular Events II (CHANCE-2): rationale and design of a multicentre randomised trial. Stroke Vasc Neurol. 2021 Jun;6(2):280-285. doi: 10.1136/svn-2020-000791. Epub 2021 May 5.