Clinical trial NCT04792983: Cognition and the Immunology of Postoperative Outcomes
Official title: Cognition and the Immunology of Postoperative Outcomes
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Cognitive Impairment
Frail Elderly Syndrome
Delirium
Surgery
Keywords: postoperative health outcomes
older surgical patients
delirium
spine surgery
Lead sponsor: Brigham and Women's Hospital
Sponsor class: OTHER
First posted: 2021-03-11
Enrollment: 600
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The cohort will consist of 600 consenting subjects ≥ 65 years of age who present for preoperative evaluation prior to elective spine surgery.

Brief summary: This research will test the hypothesis that immune system disequilibrium / dysfunction explains why preoperative cognitive impairment is a strong predictor of postoperative morbidity in older surgical patients. The investigators propose that cognitive impairment influences surgical morbidity because of underlying immune disequilibrium / dysfunction (risk marker) and that this shapes the immune response to surgery and defines immunological hallmarks of postoperative morbidity (disease marker). The overarching goal of this application therefore is to define and better understand the clinical immunology underlying the relationship between cognition and geriatric surgical morbidity.

Detailed description: This project is designed as a prospective, single-center observational study. The cohort will consist of 600 consenting subjects ≥ 65 years of age that agree to have a study investigator speak with them during their preoperative evaluation prior to elective spine surgery. These ages are chosen as significant clinical data demonstrate increased cognitive impairment in community dwelling elders. Eligibility criteria include: patients ≥ 65 years of age with an American Society of Anesthesiologists (ASA) physical status classification of I-III presenting for elective spinal surgery. Exclusion criteria will include history of stroke (not including transient ischemic attacks, or TIAs) or brain tumor, a history of autoimmune disorders, medications likely to significantly impact inflammation (e.g. steroids), current infection, uncorrected vision or hearing impairment (unable to see pictures or read or hear instructions); limited use of the dominant hand (limited ability to draw); and or inability to speak, read, or understand English.

Patients will be introduced to the study through a flyer provided to them as part of a packet from their surgeon's office. A study team member will speak with those who have agreed during their preoperative evaluation to discuss studies from the department of Anesthesiology and satisfy eligibility criteria. After obtaining informed verbal consent over the telephone, study staff will gain information about the patient's age and years of education. Study staff will conduct the following preoperative measures over the telephone: the Geriatric Depression Scale-Short (GDS), the Beck Anxiety Inventory (BAI), the Visual Analog Scale for Pain (VAS), the Fatigue, Resistance, Ambulation, Illness, and Loss of Weight scale (FRAIL), Instrumental Activities of daily living (IADLs), the Brief Pain Inventory (BPI), the World Health Organization Disability Assessment Schedule (WHODAS). In addition, all patients will be asked if they've had a fall within the last 6 months, whether they've been evaluated for a change in memory or thinking, who accompanied them to their appointment, their employment status and their living situation (alone, institutionalized, living with family members), and whether they have ever tested positive for COVID-19 in a patient survey. The study staff will administer the Montreal Cognitive Assessment (MOCA) simple cognitive screening tool that takes less than 10 minutes to complete and has little or no education, language, or race bias. Frailty will be measured using the Frail Scale. Other measures of cognitive impairment will be obtained by study staff through: documentation on the patient's standard preoperative form, patient or informant report of diagnosis or evaluation for cognitive impairment or memory concerns, and systematic medical record review. Each enrolled patient will be advised to expect a follow up telephone up to 3, 6, and 12- months after surgery to verify data elements and reassess functional outcome.

Delirium will be assessed prospectively once per day on postoperative days 1, 2, and/or 3 by a trained study team member using the Confusion Assessment Method \[CAM\] if the patient remains in the hospital and agrees to the evaluation. Delirium by chart review and CAM-ICU scores from the nursing staff will also be documented. Delirium is most common on postoperative days 1-3 and the CAM is a well-validated measure of delirium in surgical patients. To evaluate cognition and functional status, the MOCA and the WHODAS will be administered 3, 6, and 12- months postoperatively by study staff over the telephone if the patient can be contacted and continue to agree to participate. The investigators will also collect information on secondary outcomes including whether they had a surgical procedure, time to postoperative anesthesia care unit (PACU) discharge, discharge to place other than home (rehabilitation, skilled nursing facility), hospital length of stay (LOS), 30-day reoperation or readmission rate, and 30-day, 6-month, and 1-year mortality when available. These outcomes are recorded in the medical record, the BWH Balanced Scorecard, an electronic database of all hospitalized patients that tabulates 31 elements of the hospital event, or the Brigham and Women's Hospital BWH Research Patient Database Enhanced Query. Data will also be confirmed by a follow up telephone interview.

Eligibility criteria: Inclusion Criteria:

* Patients ≥ 65 years of age
* American Society of Anesthesiologists (ASA) physical status of I-III
* Scheduled for elective spine surgery.

Exclusion Criteria:

* History of stroke (not including transient ischemic attacks, or TIAs)
* History of brain tumor
* History of autoimmune disorders
* Medications likely to significantly impact inflammation (e.g. steroids)
* Current infection
* Uncorrected vision or hearing impairment
* limited use of the dominant hand (limited ability to draw)
* inability to speak, read, or understand English.

Primary outcomes:
measure: MOCA Score, Delirium, and Plasma Inflammatory Mediators
timeFrame: 5 years
measure: MOCA Score, Delirium, and the Cellular Immune Response
timeFrame: 5 years
measure: MOCA Score, Delirium and Extracellular Vesicle Immune Responses to Surgery.
timeFrame: 5 years
Secondary outcomes:
measure: Newly diagnosed perioperative health complications
timeFrame: Up to 30 days after the surgical procedure
measure: Discharge location (Home vs. other than home) on the day of patient discharge from hospital
timeFrame: Up to 30 days after the surgical procedure
measure: 30 day mortality
timeFrame: 30 days after surgical procedure
measure: 30 day re-operation or readmission
timeFrame: 30 days after surgical procedure
measure: 6 month mortality
timeFrame: 6 months after surgical procedure
measure: 1 year mortality
timeFrame: 1 year after surgical procedure
measure: Cognitive health outcome
timeFrame: 3, 6, and 12-months after surgical procedure.
measure: Functional health outcome
timeFrame: Between 6 and 12-months after surgical procedure.
Other outcomes:
Locations:
city: Boston
country: United States
facility: Brigham & Women's Hospital
state: Massachusetts
Study officials:
affiliation: Brigham & Women's Hospital; Harvard Medical School
name: Gregory J Crosby, MD
role: PRINCIPAL_INVESTIGATOR
References: