Clinical trial NCT01847261: Effects of Protein Blends on Muscle Protein Synthesis in Healthy Older Adults
Official title: A Randomized, Controlled Double Blind Acute Study: Effects of Protein Blends on Muscle Protein Synthesis and Breakdown in Healthy Older Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Muscle Synthesis
Keywords: soy
whey
muscle
older
mTOR
sarcopenia
Lead sponsor: DuPont Nutrition and Health
Sponsor class: INDUSTRY
First posted: 2013-05-06
Enrollment: 20
Sex: MALE
Minimum age (years): 55
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: During aging there is a tendency for muscle protein synthesis (growth) to become less efficient and the resulting consequence leads to reduced muscle mass (sarcopenia) which can affect strength and mobility. Protein consumption may be one opportunity to alleviate this problem especially when consumed in appropriate amounts following resistance training. This study is designed to determine if a soy dairy protein blend, shown to be effective in younger adults, will produce beneficial muscle protein synthesis in older healthy adults following resistance exercise.


Eligibility criteria: Inclusion Criteria:

55-70 yr olds Stable Body weight

Exclusion Criteria:

1. Exercise training (\>2 weekly sessions of moderate to high intensity aerobic or resistance exercise)
2. Significant heart, liver, kidney, blood, respiratory disease or thyroid issues
3. Peripheral vascular disease
4. Orthopedic injury that prohibits participation in the exercise training
5. Diabetes mellitus or other untreated endocrine disease
6. Active cancer (all groups) and history of cancer
7. Acute infectious disease or history of chronic infections (e.g. TB, hepatitis, HIV, herpes)
8. Neurologic Injury or disease
9. Recent (within 6 months) treatment with anabolic steroids, or corticosteroids.
10. Alcohol or drug abuse
11. Tobacco use (smoking or chewing)
12. Malnutrition (BMI \< 20 kg/m2, hypoalbuminemia, and/or hypotransferrinemia)
13. Obesity (BMI \> 30 kg/m2)
14. Low hemoglobin levels (below normal values)
15. Food allergies
16. Taking dietary supplements such as green tea, omega 3 fatty acids, etc.
17. Females

Primary outcomes:
measure: Fractional Synthetic Rate (Muscle Protein Synthesis)
timeFrame: baseline, 3 hrs, 5 hrs
Secondary outcomes:
measure: Anti-inflammatory and Anti-oxidant Markers
timeFrame: baseline, 3 hrs, 5 hrs
measure: Intracellular Signalling Genes and Proteins
timeFrame: baseline, 3 hrs, 5 hrs
Other outcomes:
Locations:
city: Galveston
country: United States
facility: University of Texas Medical Branch
state: Texas
Study officials:
affiliation: University of Texas
name: Blake Rasmussen, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Borack MS, Reidy PT, Husaini SH, Markofski MM, Deer RR, Richison AB, Lambert BS, Cope MB, Mukherjea R, Jennings K, Volpi E, Rasmussen BB. Soy-Dairy Protein Blend or Whey Protein Isolate Ingestion Induces Similar Postexercise Muscle Mechanistic Target of Rapamycin Complex 1 Signaling and Protein Synthesis Responses in Older Men. J Nutr. 2016 Dec;146(12):2468-2475. doi: 10.3945/jn.116.231159. Epub 2016 Oct 26.