louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04215705: Quadratus Lumborum Block III Versus Peritubal Local Infiltration
Official title: Postoperative Analgesic Efficiency of Quadratus Lumborum Block III Versus Peritubal Local Infiltration in Patients Undergoing exPercutaneous Percutaneous Nephrolithotomy Operation : a Randomized Comparative Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Postoperative Pain
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2020-01-02
Enrollment: 80
Sex: ALL
Minimum age (years): 21
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Investigators compare post operative analgesic efficacy of peritubal local infiltration versus Quadratus Lumborum Block III . In patients undergoing Percutaneous Nephrolithotomy operation


Eligibility criteria: Inclusion Criteria:

* patient with pelvic renal stone less than 2 cm
* Americans society of Anesthesiologists physical status I, II
* BMI\<35

Exclusion Criteria:

* patient refusal to participate in the study
* Americans society of Anesthesiologists physical status III or above
* major hepatic, renal or cardiovascular disease
* BMI \> 35
* coagulopathy
* psychological disorders.

Primary outcomes:
measure: Postoperative analgesia
timeFrame: 24 hours
measure: Analgesic requirement
timeFrame: 24 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Ain Shams University hosptal
state: Abbasya
Study officials:
References:
Clinical trial NCT00558805: Family Intervention for Suicidal Youth: Emergency Care
Official title: Family Intervention for Suicidal Youth: Emergency Care
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Suicide, Attempted
Lead sponsor: Centers for Disease Control and Prevention
Sponsor class: FED
First posted: 2007-11-15
Sex: ALL
Minimum age (years): 10
Maximum age (years): 18
Standard ages: CHILD
ADULT
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: This project evaluates a brief intervention in the emergency department (ED) for adolescents presenting with suicide attempts. The intervention aims to capitalize on the opportunity offered by the ED visit to deliver an effective intervention, improve adherence to follow-up care, decrease the risk of repeat suicide attempts, and improve clinical and functioning outcomes.


Eligibility criteria: Inclusion Criteria:

* 10-18 years
* Suicidal patient presenting to Emergency Department

Exclusion Criteria:

* Acute psychosis/symptoms that impede consent/assessment
* No parent/guardian to consent (youth \<18)
* Youth not English-speaking
* Parents/guardians not English or Spanish-speaking.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Los Angeles
country: United States
facility: UCLA Emergency Medical Center
state: California
city: Los Angeles
country: United States
facility: Los Angeles County Harbor-UCLA Medical Center
state: California
Study officials:
affiliation: University of California, Los Angeles
name: Joan R Asarnow, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Asarnow JR, Baraff LJ, Berk M, Grob CS, Devich-Navarro M, Suddath R, Piacentini JC, Rotheram-Borus MJ, Cohen D, Tang L. An emergency department intervention for linking pediatric suicidal patients to follow-up mental health treatment. Psychiatr Serv. 2011 Nov;62(11):1303-9. doi: 10.1176/ps.62.11.pss6211_1303.
Clinical trial NCT01282905: Hydrogen Sulfide Detoxification and Butyrate Metabolism in Ulcerative Colitis
Official title: Impact of the Mucosal Detoxification Mechanism of Hydrogen Sulphide on the Oxidation Pathway of Butyrate in Ulcerative Colitis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Ulcerative Colitis
Lead sponsor: KU Leuven
Sponsor class: OTHER
First posted: 2011-01-25
Enrollment: 106
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: IBD patients clinic (Universitaire Ziekenhuizen Leuven)

Brief summary: The purpose of this study is to evaluate the relation between sulphide detoxification and butyrate metabolism at the level of gene expression and enzyme activity in ulcerative colitis patients and healthy controls.


Eligibility criteria: Inclusion Criteria:

- Ulcerative colitis patients: patients diagnosed with ulcerative colitis

Exclusion Criteria:

* Healthy controls: no diagnosis of inflammatory bowel diseases
* Intake of antibiotics in the last month before the study

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Leuven
country: Belgium
facility: KULeuven
Study officials:
affiliation: KU Leuven
name: Kristin Verbeke, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05264805: Effectiveness of Port Site Bupivacaine Injection in Postoperative Pain Reduction After Lap. Chole
Official title: A Randomized Controlled Trial of Port Site Subcutaneous Injection of Bupivacaine to Determine the Effectiveness of Postoperative Pain Relief After Laparoscopic Cholecystectomy
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE3
Conditions: Pain, Postoperative
Keywords: #Post operative pain
#laparoscopic cholecystectomy
Lead sponsor: Hamdard University
Sponsor class: OTHER
First posted: 2022-03-03
Enrollment: 166
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Group A:

Study group: Patient receiving intervention i.e 20ml of 0.25% buvivacaine infiltration at laparoscopic port site.

Group B:

Control group: no intervention
Primary purpose: TREATMENT

Brief summary: To determine the effectiveness of port site bupivacaine infiltration in postoperative pain reduction after laparoscopic cholecystectomy.

Detailed description: The study is being done to determine the effectiveness of port site bupivacaine infiltration in postoperative pain reduction after laparoscopic cholecystectomy.

Eligibility criteria: Inclusion Criteria:

1. Patients of both the gender of age \>18 years and \<45years
2. Patients undergoing elective laparoscopic cholecystectomy under general anesthesia.
3. Patients with A.S.A grade I and II.

Exclusion Criteria:

1. Patients with known allergic reactions to local anesthetics.
2. Patients converted to open procedure.
3. Patients developing intra-operative complications.
4. Patients undergoing for laparoscopic cholecystectomy for acute cholecystitis.
5. Patients with obesity and chronic illness.
6. Patients with history of opioids, steroids, NSAIDs and alcohol use.

Primary outcomes:
measure: Post laparoscopic port site pain assessment
timeFrame: Pain assessment from 0hour (patient received in recovery room) till 12hours postoperatively at interval of 3hours i.e. 0,3,6,9,12 hour
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02399605: Subcutaneous Electrical Stimulation in the Prevention of Postoperative Ileus
Official title: Subcutaneous Electrical Stimulation in the Prevention of Postoperative Ileus in Colorectal Surgery
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Ileus
Lead sponsor: Hospital General Universitario Elche
Sponsor class: OTHER
First posted: 2015-03-26
Enrollment: 500
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Assess whether the application of electrical stimulation in patients undergoing subcutaneous colon cancer in a Multimodal Rehabilitation Program (Fast track) decreases the incidence of postoperative ileus, improving the results of morbidity and mortality, hospitalization and health care costs.

Detailed description: Prospective randomized study on the application of subcutaneous abdominal electrical stimulation in the postoperative of colonic surgery and its relationship with the appearance of postoperative ileus.

Eligibility criteria: Inclusion Criteria:

* Patients undergoing colorectal surgery.
* Signing informed consent.

Exclusion Criteria:

* Patients with no oral nutrition (dysphagia, esophageal stricture, pyloric stenosis)
* Patients with contraindications for electrical stimulation.
* Psychiatric Disorders
* HIV
* Pregnant or breastfeeding
* intestinal obstruction
* uncontrolled infection
* ASA IV
* No acceptance or failure to follow protocol multimodal rehabilitation.

Primary outcomes:
measure: Time to first flatus
timeFrame: Participants will be followed for the duration of hospital stay, an expected average of 5 days
Secondary outcomes:
Other outcomes:
Locations:
city: Alicante
country: Spain
facility: Pedro Moya
city: Elche
country: Spain
facility: Pedro Moya
Study officials:
affiliation: HGU ELCHE
name: Pedro Moya, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05605405: Prevalence and Associated Factors of Functional Gastrointestinal Disorders Among Children
Official title: Prevalence and Associated Factors of Functional Gastrointestinal Disorders Among Children Attending Assuit University Children Hospital
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Functional Gastrointestinal Disorders
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2022-11-04
Enrollment: 269
Sex: ALL
Minimum age (years): 1
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Children having functional GI symptoms according Rome IV criteria

Brief summary: The definition of Functional Gastrointestinal Disorders (FGIDs) has changed over time from the absence of organic disease to a stress-related or psychiatric disorder to a motility disorder, and with Rome III, to a disorder of GI functioning, then Rome iv in 2016 defined FGIDs as : disorders of gut-brain interaction. It is a group of disorders classified by GI symptoms related to any combination of the following: motility disturbance, visceral hypersensitivity,altered mucosal and immune function, altered gut microbiota, and altered central nervous system (CNS) processing. FGIDs are observed in infants and young children worldwide with variable frequency related studies done in variable places around the worled show the following results : the prevalence of FGIDs in Chinese infants and young children is 27.3%.and 40 % in south american infants and 30 % of african infants and 35.1 % of infants presented to tertiary care hospital in Istunbul.Turkey.

Detailed description: The etiology of these disorders remains uncertain and thought to be due to subtle alteration of the normal development or maladaptive behavioral response to a variety of internal or external stimuli .As a group of disorders; FGIDs in young children are a major challenge to the already overstretched pediatric gastroenterology services across the world .Infants and young children with FGIDs visit medical professionals more frequently and experience poor quality of life . In addition, FGIDs in infancy are linked with detrimental repercussions such as maternal depression, poor infant and mother bonding,and poor physical growth .

Eligibility criteria: Inclusion Criteria:

* Age group 1 to 18 years old

Exclusion Criteria:

* Age group bwlow 1 year and above 18 years

Having other git problem as :

* GIT bleeding
* H pylori infection
* Cow's milk protein allergy or IBD or any other symptoms suggestive to organic GI disease

Primary outcomes:
measure: Prevalence of functional gastrointestinal disorders among children attending gastrointerology clinic of Assuit University Children Hospital
timeFrame: 50 weeks
measure: The associated factors
timeFrame: 50 weeks
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT00136305: Comparing Asthma Action Plans for Pediatric Asthma
Official title: Relative Effectiveness of Pictorial and Written Asthma Action Plans for Pediatric Asthma
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE2
Conditions: Asthma
Keywords: pediatric asthma
asthma action plans
patient education
medication adherence
Lead sponsor: Children's Mercy Hospital Kansas City
Sponsor class: OTHER
Collaborators: name: Katherine B. Anderson Associates Endowment Fund
First posted: 2005-08-29
Enrollment: 4
Sex: ALL
Minimum age (years): 6
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate and compare the relative effectiveness of two asthma action plans (pictorial versus written) in terms of asthma action plan knowledge, medication use, and family satisfaction with asthma education.

Detailed description: Asthma medical regimens are complex for families, requiring changes in the types and amounts of medication based on the frequency and intensity of symptoms. Written asthma action plans (AAP's) are commonly used to provide a set of instructions to help parents and children implement these complicated regimens. However, written AAP's require substantial literacy levels, so for younger children, low-literacy families, or non-English speaking families, a pictorial version of the AAP may be more understandable and useful. The study aims to validate a newly developed, fully pictorial AAP in terms of its relative impact on parent- and child-reported knowledge of the action plan, medication use, and parent- and child-reported satisfaction, when compared to a standard-care written AAP.

Eligibility criteria: Inclusion Criteria:

* Children who are new patients
* Receive a diagnosis of persistent asthma
* Are in need of an asthma action plan

Exclusion Criteria:

* Diagnosed with intermittent asthma
* An established patient who already has an asthma action plan
* Not English or Spanish speaking

Primary outcomes:
measure: Scores on the Asthma Action Plan Knowledge Interview
timeFrame: 1 month
Secondary outcomes:
measure: Adherence to Controller Medication
timeFrame: 1 month
measure: Rescue Medication Use
timeFrame: 1 month
measure: Family satisfaction survey scores
timeFrame: 1 month
Other outcomes:
Locations:
city: Kansas City
country: United States
facility: The Children's Mercy Hospitals and Clinics
state: Missouri
Study officials:
affiliation: The Children's Mercy Hospitals and Clinics
name: Christina D Adams, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01774305: Effect of Single-dose Dexmedetomidine on Airway Reflex in Adult With Oral Intubation After Thyroidectomy
Official title: Effect of Single-dose Dexmedetomidine on Airway Reflex in Adult With Oral Intubation After Thyroidectomy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Coughing
Lead sponsor: Yonsei University
Sponsor class: OTHER
First posted: 2013-01-23
Enrollment: 141
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Coughing during emergence from general anaesthesia may lead to dangerous effects including laryngospasm, detrimental haemodynamic changes. Post-thyroidectomy bleeding occurs in 1-4% of patients, and severe coughing may cause bleeding. Dexmedetomidine, a potent α adrenoreceptor agonist, is theoretically appropriate for reducing airway and haemodynamic reflexes during emergence from anaesthesia.

In this study, we investigated whether intravenous single-dose dexmedetomidine at the end of surgery reduces coughing during extubation after thyroidectomy.


Eligibility criteria: Inclusion Criteria:

* ASA physical status 1 or 2 patients patients scheduled for thyroidectomy

Exclusion Criteria:

* Severe cardiovascular disease history of motion sickness active status of upper respiratory infection allergy to dexmedetomidine patients who cannot understand Korean

Primary outcomes:
measure: Coughing Grade
timeFrame: from the time of eye opening to 5 min after extubation
Secondary outcomes:
measure: Emergence Time
timeFrame: from sevoflurane discontinuation, up to the time of eye opening (estimated time : from 5 min to 10 min)
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Gangnam severance hospital
Study officials:
References:
citation: Lee JS, Choi SH, Kang YR, Kim Y, Shim YH. Efficacy of a single dose of dexmedetomidine for cough suppression during anesthetic emergence: a randomized controlled trial. Can J Anaesth. 2015 Apr;62(4):392-8. doi: 10.1007/s12630-014-0295-6. Epub 2014 Dec 19.
Clinical trial NCT01251705: Comparation of Different Devices to Measure Corneal Thickness
Official title: Comparation of Different Devices to Measure Corneal Thickness
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Corneal Thickness
Keywords: Cornea
SL OCT
Spectral OCT Cornea modul
ultrasound pachymetry
Pentacam
Lead sponsor: Technische Universität Dresden
Sponsor class: OTHER
First posted: 2010-12-02
Enrollment: 70
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: volunteers without corneal disease

Brief summary: Comparison of different methods for measuring peoples corneal thickness

Detailed description: Volunteers with healthy corneas will be measured by different instruments to detect their corneal thickness. First interindividual difference between the instruments will be reviewed. People will be measured again two times on two different days to examine an interindividual difference in all instruments.

Eligibility criteria: Inclusion Criteria:

* healthy cornea

Exclusion Criteria:

* myopia or astigmatism over 1,5 dpt
* corneal surgery
* acute ocular inflammation
* lost of vision

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Dresden
country: Germany
facility: Departement of Ophthalmology
state: Saxonia
Study officials:
affiliation: Departement of Ophthalmology University of Dresden
name: Haustein, Doctor med.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06508905: Sleep Buddy Application in Hospitalized Children
Official title: The Effect of Sleep Companion Application on Psychosocial Symptoms in Hospitalized Children
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Main Heading (Descriptor) Terms
Keywords: hospital
child
sleep companion
psychosocial symptoms
Lead sponsor: Istanbul Medipol University Hospital
Sponsor class: OTHER
First posted: 2024-07-18
Enrollment: 97
Sex: ALL
Minimum age (years): 6
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The study was planned as a randomized controlled experimental study to investigate the effect of sleep companion application on psychosocial symptoms in hospitalized school children aged 6-12 years.

Detailed description: The sample of the study consisted of a total of 97 school-age children hospitalized in the Pediatrics and Pediatric Surgery-Endocrine Service of the Health Services Application and Research Hospital of a university hospital and in the Pediatrics Service of a state hospital. Children who met the inclusion criteria and whose written and verbal consent was obtained from their parents for participation in the study after being informed were included in the study.

The study was completed as 50 control and 47 experimental group with 3 missing persons in the experimental group.

Data were collected using the "Introductory Information Form" and "Psychosocial Symptoms Diagnostic Scale for Hospitalized Children (PSDS)" tools.

The toy, which was selected as a sleep companion for the children in the experimental group, was introduced to the children and accompanied them for 3 days during their hospitalization. The experimental and control groups were observed for psychosocial symptoms.

The data will be analyzed with SPSS software.

Eligibility criteria: Inclusion Criteria:

* Hospitalized school-age children (6-12 years old),
* No mental disability,
* Volunteer to participate in the research,
* No allergies,
* Children who are hospitalized for at least 3 days

Exclusion Criteria:

* Hospitalized children under 6 years of age and over 12 years of age,
* Predicted discharge in less than 3 days,
* Children with a sleeping companion

Primary outcomes:
measure: Psychosocial symptoms diagnostic scale
timeFrame: Used 3 days after the sleep companion app. The scale administration took 15 minutes.
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Medipol University
state: Beykoz
Study officials:
affiliation: Medipol University
name: Aysel Kokcu Dogan, Ph.D
role: STUDY_DIRECTOR
References:
Clinical trial NCT04988698: Factors Predicting the Duration of Effectiveness of Viscosupplementation in Knee Arthosis
Official title: Factors Predicting the Duration of Effectiveness of Viscosupplementation in Knee Arthosis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Knee Osteoarthritis
Keywords: viscosupplementation
Lead sponsor: Hopital Nord Franche-Comte
Sponsor class: OTHER
First posted: 2021-08-03
Enrollment: 103
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: A questionnaire is administered by the investigator during the medical consultation. No act is performed outside of patient care.

Brief summary: Knee osteoarthritis is a frequent condition whose prevalence is estimated at 7.6% of the French population aged 40 to 75, or approximately 2 million individuals . Viscosupplementation (VS) is a symptomatic treatment of knee osteoarthritis recommended by a large number of learned societies. It consists of the intra-articular injection (IA) of hyaluronic acid (HA), to reduce knee pain by restoring normal joint homeostasis impaired by endogenous HA deficiency.

The IA administration of HA can be performed using 2 protocols: repeated weekly injections (3, sometimes 5 injections) and single injections. To date and there is no argument to favor either protocol. Regardless of the formula used, the safety of HA is excellent (RR of adverse reaction versus saline = 1.01, 95% CI 0.96-1.07, P = 0.6). The indication for viscosupplementation is the symptomatic treatment of mild to moderate knee osteoarthritis after failure and / or intolerance of analgesics or nonsteroidal anti-inflammatory drugs (NSAIDs). In this indication, after HA injection the responder rate is in the order of 70% to 75% at 6 months and approximately 50% at 12 months. However, the predictors of the duration of effectiveness of SV are still unknown. The objective of the study is to research the factors influencing the duration of the effectiveness of SV, under real life conditions.


Eligibility criteria: Inclusion Criteria:

* All adult outpatients, of both sexes, regardless of age, with a doctor-accepted diagnosis of knee OA and who have been treated with SV within the past 3 years

Exclusion Criteria:

* Patients who have not been treated with SV in the past 3 years.
* Patients who have been treated with VS for an indication other than osteoarthritis of the knee.
* Patients in whom the assessment could not be performed reliably

Primary outcomes:
measure: Investigate the factors influencing the duration of the effectiveness of SV, under real-life conditions
timeFrame: At inclusion
Secondary outcomes:
measure: Research for predictive factors will be carried out on the duration of satisfaction
timeFrame: At inclusion
Other outcomes:
Locations:
city: Trévenans
country: France
facility: Hôpital Nord Franche-Comté
Study officials:
References: