Clinical trial NCT02467309: Vitamin d Levels in Children With Bacterial Meningitis
Official title: Association of Serum 25-hydroxyvitamin D Levels and Outcomes in Children With Bacterial Meningitis
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Bacterial Meningitis
Lead sponsor: Beijing Children's Hospital
Sponsor class: OTHER
First posted: 2015-06-10
Enrollment: 50
Sex: ALL
Minimum age (years): 1
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients who are diagnosed with bacterial meningitis in infectious diseases department of Beijing Children's Hospital

Brief summary: The purpose of this study is to determine whether deficiency of Vitamin D has association with outcomes of children with bacterial meningitis.

Detailed description: Vitamin D deficiency has been proved in serious diseases patients, including patients in shock, however, few study have been done about association between deficiency of Vitamin D and outcomes of children with bacterial meningitis.

in our study, we will observe incidence of complication and severity of complication between patients who have different Vitamin D status.

Eligibility criteria: Inclusion Criteria:

* Probable bacterial meningitis patients: Clinical manifestation (Any person with sudden onset of fever (\> 38.5 °C rectal or 38.0 °C axillary) and one of the following signs: neck stiffness, altered consciousness or other meningeal sign) with cerebrospinal fluid examination showing at least one of the following:

A. turbid appearance; B.leukocytosis (\> 100 cells/mm3); C.leukocytosis (10-100 cells/ mm3) AND either an elevated protein (\> 100 mg/dl) or decreased glucose (\< 40 mg/dl)

* Confirmed bacterial meningitis patients: A case that is laboratory-confirmed by growing (i.e. culturing) or identifying (i.e. by Gram stain or antigen detection methods) a bacterial pathogen (Hib, pneumococcus or meningococcus) in the cerebrospinal fluid or from the blood in a child with a clinical syndrome consistent with bacterial meningitis

Exclusion Criteria:

* Congenital immunodeficiency patients
* HIV patients
* Patients with corticosteroid treatment for long time
* Patients with disorders in adrenal gland and pituitary gland and hypothalamus
* Patients with tuberculosis

Primary outcomes:
measure: vitamin d level change
timeFrame: change in serum vitamin d level from baseline to 28 days after initial hospitalization
Secondary outcomes:
measure: Clinical assessment of disease severity with Glasgow score
timeFrame: 1 day
measure: Clinical assessment of disease severity with Glasgow score
timeFrame: 7 day
measure: Clinical assessment of disease severity with Glasgow score
timeFrame: 28 day
measure: Clinical assessment of disease severity with pediatric critical illness score
timeFrame: 1 day
measure: Clinical assessment of disease severity with pediatric critical illness score
timeFrame: 7 day
measure: Clinical assessment of disease severity with pediatric critical illness score
timeFrame: 28 day
measure: Clinical assessment of disease severity with cerebrospinal fluid examination
timeFrame: 1 day
measure: Clinical assessment of disease severity with cerebrospinal fluid examination
timeFrame: 7 day
measure: Clinical assessment of disease severity with cerebrospinal fluid examination
timeFrame: 28 day
measure: Assessment of complications
timeFrame: 1 day
measure: Assessment of complications
timeFrame: 7 day
measure: Assessment of complications
timeFrame: 28 day
Other outcomes:
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