Clinical trial NCT03995693: Fuel Selection During Eccentric Cycling With Glucose Ingestion
Official title: Fuel Selection During Eccentric Cycling: Comparison With Concentric Cycling and the Effect of Glucose Ingestion During Exercise
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Exercise
Damage Muscle
Nutrition
Keywords: eccentric exercise
13C-glucose
exercise mode
Lead sponsor: Université de Montréal
Sponsor class: OTHER
First posted: 2019-06-24
Enrollment: 75
Sex: MALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SEQUENTIAL
Primary purpose: BASIC_SCIENCE

Brief summary: This study compares fuel selection during eccentric and concentric cycling, with (placebo) or without glucose ingestion during exercise. After a 2-week familiarization and habituation with the ergometers, subjects will complete four experimental conditions in a randomized order: concentric with placebo, eccentric with placebo, concentric with glucose, eccentric with glucose.

Detailed description: Cycling on a cycle ergometer typically requires repeated concentric muscle contractions to push on the pedals and produce mechanical work. An eccentric cycling ergometer has a motor that rotates the cranks with a predetermined torque, the cyclist needs to resist to the movement of the cranks. This leads to eccentric muscle contractions, the work is thus produced while the muscle is lengthening (negative work). This mode of exercise is known to produce a lower oxygen consumption (energy cost) for the same mechanical power output and also leads to muscle damage which can interfere with fuel selection.

Eligibility criteria: Inclusion Criteria:

* Low alcohol consumption (\<3 drinks/week)
* Non-smokers
* Not regularly taking medication for a known pathology
* Regularly practices endurance sports (cycling, running, etc.)

Exclusion Criteria:

* Intolerant to glucose (according to WHO standards)
* Musculoskeletal injury or illness affecting exercise performance
* Failure to respect protocol guidelines (diet, exercise prior to experimentation, etc.)

Primary outcomes:
measure: Exogenous glucose oxidation
timeFrame: Average over the 35 minutes of eccentric or concentric exercise
measure: Maximal voluntary force production
timeFrame: Change between baseline and end of exercise
measure: Central and skin temperature
timeFrame: Average over the 35 minutes of eccentric or concentric exercise
measure: Perceived exertion
timeFrame: Average over the 35 minutes of eccentric or concentric exercise
Secondary outcomes:
measure: Blood insulin concentration
timeFrame: For 0 minutes corresponds to the beginning of exercise, at -31, -1, 14, 29, 44, 49, 59 and 69 minutes
measure: Blood glucose concentration
timeFrame: For 0 minutes corresponds to the beginning of exercise, at -31, -1, 14, 29, 44, 49, 59 and 69 minutes
measure: Blood free-fatty acid concentration
timeFrame: For 0 minutes corresponds to the beginning of exercise, at -31, -1, 14, 29, 44, 49, 59 and 69 minutes
measure: Blood lactate concentration
timeFrame: For 0 minutes corresponds to the beginning of exercise, at -31, -1, 14, 29, 44, 49, 59 and 69 minutes
measure: Total carbohydrate, fat and protein oxidation
timeFrame: Average over the 35 minutes of eccentric or concentric exercise
measure: Pain perception: VAS
timeFrame: Average over the 35 minutes of eccentric or concentric exercise
measure: Affective response
timeFrame: Average over the 35 minutes of eccentric or concentric exercise
Other outcomes:
Locations:
city: Montréal
country: Canada
facility: Centre d'éducation physique et sportive de l'Université de Montréal (CEPSUM)
state: Quebec
Study officials:
affiliation: Université de Montréal
name: Jonathan Tremblay, PhD
role: PRINCIPAL_INVESTIGATOR
References: