Clinical trial NCT06468228: A Study to Assess Disease Activity and Safety of Lutikizumab in Adult and Adolescent Participants With Moderate to Severe Hidradenitis Suppurativa
Official title: A Phase 3 Multicenter, Randomized, Double-Blind Placebo-Controlled Study to Evaluate the Efficacy and Safety of Lutikizumab in Adult and Adolescent Subjects With Moderate to Severe Hidradenitis Suppurativa
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE3
Conditions: Hidradenitis Suppurativa
Lead sponsor: AbbVie
Sponsor class: INDUSTRY
First posted: 2024-06-21
Enrollment: 1280
Sex: ALL
Minimum age (years): 12
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Hidradenitis suppurativa (HS) is a chronic and often painful inflammatory skin disease which includes the forming of lumps, abscesses and scars in areas of the skin such as under the breasts, under armpits, inner thighs, groin and buttocks. This study will compare lutikizumab versus placebo for the treatment of adult and adolescent participants with the signs and symptoms of moderate to severe HS .

Lutikizumab is an investigational drug being developed for the treatment of HS. During Period 1 of the study, participants will placed in 1 of 2 groups called treatment arms. There is a 1 in 2 chance that participants will be assigned to placebo. Around 1280 adult and adolescent participants with moderate to severe HS will be enrolled in the study at approximately 275 sites world wide. During Period 2, participants that were part of the lutikizumab treatment arm in Period 1 will be re-randomized to 1 of 2 lutikizumab treatment arms. Participants that were part of the Placebo arm in Period 1 will start Period 2 with an initiation of lutikizumab followed by a re-randomization to 1 of 2 lutikizumab treatment arms.

In Period 1, participants will receive subcutaneous injections of lutikizumab or placebo every week for 16 weeks. In Period 2, participants that were randomized to lutikizumab in Period 1 will receive subcutaneous injections of lutikizumab every week or every other week for 36-weeks. Participants that were randomized to the placebo arm in Period 1 will receive subcutaneous injections of lutikizumab every week for 16 weeks, then either every week or every other week for 20 weeks.

Period 3 is the Long Term Extentsion (LTE) and through Week 68, participants will continue to receive lutikizumab SC using the same assigned dosing regimen from the end of Period 2 for 16 weeks followed by open-label lutikizumab EOW for 140 weeks.

Participants in the US that complete Periods 1 \& 2 will have the option to enroll in a 156-week open-label Sub-Study that will assess the long term safety and efficacy of lutikizumab in a prefilled pen.

There may be higher treatment burden for participants in this trial compared to their standard of care. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, checking for side effects and completing questionnaires and diaries.


Eligibility criteria: Inclusion Criteria:

* Diagnosis of moderate to severe HS for at least 6 months prior to Baseline as determined by the investigator (i.e., through medical history and interview of participant).
* Total abscess and inflammatory nodule (AN) count of ≥ 5 at Baseline
* Hidradenitis suppurativa (HS) lesions present in at least two distinct anatomic areas at Baseline.
* At least 1 anatomic area of HS involvement characterized as Hurley Stage II or higher at Baseline.

Exclusion Criteria:

* Any evidence of Hepatitis B virus (HBV) or hepatitis C virus (HCV) infection.
* Confirmed positive anti-HIV antibody (HIV Ab) test.
* Evidence of active tuberculosis or meets tuberculosis exclusionary parameter

Primary outcomes:
measure: Percentage of Participants Achieving Hidradenitis Suppurative Clinical Response (HiSCR) 75
timeFrame: At Week 16
measure: Number of Participants with Adverse Events (AEs)
timeFrame: Up to Approximately Week 62
Secondary outcomes:
measure: Percentage of Participants Achieving Numeric Rating Scale (NRS) 30 among Participants with Baseline NRS >=3
timeFrame: At Week 8
measure: Change from Baseline in Dermatology Life Quality Index (DLQI) among participants ≥ 16 years of age at Baseline
timeFrame: At Week 16
measure: Change from Baseline in Hidradenitis Suppurativa Impact Assessment (HSIA)
timeFrame: At Week 16
measure: Change from Baseline in Hidradenitis Suppurativa Symptom Assessment (HSSA) Worst Drainage Score
timeFrame: At Week 16
measure: Change from Baseline in number of Draining Fistulas Count among participants with at least 1 draining fistula at Baseline
timeFrame: At Week 16
measure: Percentage of Participants Achieving HiSCR 90
timeFrame: At Week 16
measure: Change from Baseline in the Patient's Global Assessment of HS-related Skin Pain (NRS)
timeFrame: At Week 8
measure: Change from Baseline in HSSA
timeFrame: At Week 16
measure: Change from Baseline in the Patient's Global Assessment of HS-related Odor (smell), based on the HSSA Question 8
timeFrame: At Week 16
measure: Percentage of Participants with an Occurrence of HS Flare in Period 1
timeFrame: Baseline to Week 16
measure: Change from Baseline in Hidradenitis Suppurativa Impact Assessment (HSIA) Emotional Domain
timeFrame: At Week 16
measure: Change from Baseline in HSIA Mobility Domain
timeFrame: at Week 16
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: Cahaba Dermatology & Skin Health Center /ID# 263795
state: Alabama
city: Phoenix
country: United States
facility: Medical Dermatology Specialists /ID# 263394
state: Arizona
city: Bryant
country: United States
facility: Dermatology Trial Associates /ID# 264587
state: Arkansas
city: North Little Rock
country: United States
facility: Arkansas Research Trials /ID# 263901
state: Arkansas
city: Encino
country: United States
facility: Private Practice - Dr. Tooraj Raoof /ID# 263756
state: California
city: Los Angeles
country: United States
facility: Dermatology Research Associates - Los Angeles /ID# 263765
state: California
city: Redwood City
country: United States
facility: Stanford University School of Medicine - Redwood City /ID# 263711
state: California
city: Sacramento
country: United States
facility: Integrative Skin Science and Research /ID# 264600
state: California
city: Thousand Oaks
country: United States
facility: Clinical Trials Research Institute /ID# 263743
state: California
city: Boca Raton
country: United States
facility: Clearlyderm Dermatology - West Boca /ID# 265023
state: Florida
city: Brandon
country: United States
facility: Apex Clinical Trials /ID# 263815
state: Florida
city: Brandon
country: United States
facility: TrueBlue Clinical Research /ID# 265041
state: Florida
city: Hollywood
country: United States
facility: Skin Care Research - Hollywood /ID# 263805
state: Florida
city: Margate
country: United States
facility: GSI Clinical Research, LLC /ID# 263827
state: Florida
city: Miami
country: United States
facility: Sullivan Dermatology /ID# 263511
state: Florida
city: Ocala
country: United States
facility: Renstar Medical Research - Ocala - Northeast 1st Avenue /ID# 263842
state: Florida
city: Tampa
country: United States
facility: Skin Care Research - Tampa /ID# 263819
state: Florida
city: Tampa
country: United States
facility: Advanced Clinical Research Institute /ID# 263808
state: Florida
city: Tampa
country: United States
facility: University of South Florida /ID# 269624
state: Florida
city: Tampa
country: United States
facility: Alliance Clinical Research of Tampa /ID# 264594
state: Florida
city: Columbus
country: United States
facility: Centricity Research Columbus Dermatology /ID# 266530
state: Georgia
city: Dawsonville
country: United States
facility: Cleaver Medical Group Dermatology /ID# 263845
state: Georgia
city: Boise
country: United States
facility: Treasure Valley Medical Research /ID# 263671
state: Idaho
city: Chicago
country: United States
facility: Northwestern University Feinberg School of Medicine /ID# 265007
state: Illinois
city: Rolling Meadows
country: United States
facility: Arlington Dermatology /ID# 263410
state: Illinois
city: Indianapolis
country: United States
facility: Dawes Fretzin, LLC /ID# 264601
state: Indiana
city: Leawood
country: United States
facility: Dermatology Partners of Leawood /ID# 263533
state: Kansas
city: Bowling Green
country: United States
facility: Equity Medical, LLC /ID# 268590
state: Kentucky
city: Louisville
country: United States
facility: Dermatology Specialists Research (DS Research) - Kentucky /ID# 263343
state: Kentucky
city: New Orleans
country: United States
facility: Tulane University School of Medicine /ID# 263899
state: Louisiana
city: Boston
country: United States
facility: Beth Israel Deaconess Medical Center /ID# 263709
state: Massachusetts
city: Canton
country: United States
facility: Hamzavi Dermatology - Canton /ID# 263538
state: Michigan
city: Clarkston
country: United States
facility: Michigan Center for Medical Research /ID# 263547
state: Michigan
city: Lee's Summit
country: United States
facility: Dermatology and Skin Center of Lees Summit /ID# 263567
state: Missouri
city: Saint Joseph
country: United States
facility: MediSearch Clinical Trials /ID# 263582
state: Missouri
city: Las Vegas
country: United States
facility: Vivida Dermatology- Flamingo /ID# 263716
state: Nevada
city: Lebanon
country: United States
facility: Dartmouth Hitchcock Medical Center - Old Etna Road /ID# 263713
state: New Hampshire
city: Portsmouth
country: United States
facility: ActivMed Practice and Research, LLC /ID# 263387
state: New Hampshire
city: New York
country: United States
facility: Mount Sinai Doctors - Dermatology /ID# 264602
state: New York
city: Winston-Salem
country: United States
facility: Atrium Health Wake Forest Baptist Medical Center /ID# 264507
state: North Carolina
city: Bexley
country: United States
facility: Dermatology of Greater Columbus /ID# 263497
state: Ohio
city: Cleveland
country: United States
facility: University Hospitals Cleveland Medical Center /ID# 263600
state: Ohio
city: Gahanna
country: United States
facility: Ohio State Officenter Gahanna /ID# 263598
state: Ohio
city: Mason
country: United States
facility: Dermatologists of Southwest Ohio - Mason /ID# 263588
state: Ohio
city: Mayfield Heights
country: United States
facility: Apex Clinical Research Center /ID# 272787
state: Ohio
city: Philadelphia
country: United States
facility: Dermatology Partners /ID# 264999
state: Pennsylvania
city: Pittsburgh
country: United States
facility: University of Pittsburgh Medical Center /ID# 264590
state: Pennsylvania
city: Charleston
country: United States
facility: Clinical Research Center of the Carolinas /ID# 263407
state: South Carolina
city: Charleston
country: United States
facility: Medical University of South Carolina /ID# 263890
state: South Carolina
city: Spartanburg
country: United States
facility: ADCS - Spartanburg /ID# 267207
state: South Carolina
city: Arlington
country: United States
facility: Arlington Research Center, Inc /ID# 263895
state: Texas
city: Bellaire
country: United States
facility: Bellaire Dermatology Associates /ID# 263850
state: Texas
city: Cypress
country: United States
facility: Studies in Dermatology LLC /ID# 263399
state: Texas
city: Dallas
country: United States
facility: Reveal Research Institute, Dallas /ID# 267233
state: Texas
city: Houston
country: United States
facility: Center for Clinical Studies - Houston - Binz Street /ID# 263378
state: Texas
city: Plano
country: United States
facility: Texas Dermatology Research Center /ID# 264488
state: Texas
city: San Antonio
country: United States
facility: Texas Dermatology and Laser Specialists /ID# 263778
state: Texas
city: Tyler
country: United States
facility: Dermatology Associates of Tyler /ID# 265002
state: Texas
city: Murray
country: United States
facility: University of Utah /ID# 263818
state: Utah
city: Norfolk
country: United States
facility: Virginia Clinical Research /ID# 264553
state: Virginia
city: Spokane
country: United States
facility: Dermatology Specialists of Spokane /ID# 264499
state: Washington
city: Phillip
country: Australia
facility: Paratus Clinical Research Woden /ID# 263125
state: Australian Capital Territory
city: Darlinghurst
country: Australia
facility: Momentum Clinical Research /ID# 263192
state: New South Wales
city: Kogarah
country: Australia
facility: Premier Dermatology /ID# 263124
state: New South Wales
city: Woolloongabba
country: Australia
facility: Veracity Clinical Research /ID# 263126
state: Queensland
city: East Melbourne
country: Australia
facility: Sinclair Dermatology - Melbourne /ID# 263121
state: Victoria
city: Graz
country: Austria
facility: Medizinische Universitaet Graz /ID# 263306
state: Steiermark
city: Wien
country: Austria
facility: Medizinische Universitaet Wien /ID# 264043
city: Anderlecht
country: Belgium
facility: Universite Libre de Bruxelles - Hopital Erasme /ID# 263097
state: Bruxelles-Capitale
city: Bruxelles
country: Belgium
facility: Cliniques Universitaires UCL Saint-Luc /ID# 263096
state: Bruxelles-Capitale
city: Jette
country: Belgium
facility: Universitair Ziekenhuis Brussel /ID# 263101
state: Bruxelles-Capitale
city: Charleroi
country: Belgium
facility: Grand Hôpital de Charleroi - Les Viviers /ID# 263100
state: Hainaut
city: Liège
country: Belgium
facility: CHU de Liège /ID# 263095
state: Liege
city: Gent
country: Belgium
facility: UZ Gent /ID# 263099
state: Oost-Vlaanderen
city: Leuven
country: Belgium
facility: Universitair Ziekenhuis Leuven /ID# 263098
state: Vlaams-Brabant
city: Banja Luka
country: Bosnia and Herzegovina
facility: Klinicki centar Banja Luka /ID# 265905
state: Republika Srpska
city: Banja Luka
country: Bosnia and Herzegovina
facility: Klinicki centar Banja Luka /ID# 265909
state: Republika Srpska
city: Sarajevo
country: Bosnia and Herzegovina
facility: Clinical Center University of Sarajevo - Bolnička /ID# 265908
city: Sofiya
country: Bulgaria
facility: Acibadem City Clinic Tokuda Hospital /ID# 263300
state: Sofia
city: Sofiya
country: Bulgaria
facility: ASMC-IPSMC-Skin and Venereal Diseases /ID# 262891
state: Sofia
city: Sofiya
country: Bulgaria
facility: Medical Center Hera EOOD /ID# 263010
state: Sofia
city: Pleven
country: Bulgaria
facility: Medical Center Cordis /ID# 262894
city: Sofiya
country: Bulgaria
facility: Diagnostic consultative center Focus-5 /ID# 262893
city: Stara Zagora
country: Bulgaria
facility: UMHAT Professor Stoyan Kirkovich /ID# 262892
city: Calgary
country: Canada
facility: Beacon Dermatology Inc /ID# 264262
state: Alberta
city: Edmonton
country: Canada
facility: Rejuvenation Dermatology - Edmonton Downtown /ID# 265963
state: Alberta
city: Edmonton
country: Canada
facility: Stratica Dermatology /ID# 265856
state: Alberta
city: Kelowna
country: Canada
facility: Interior Dermatology Centre - Probity - PPDS /ID# 266202
state: British Columbia
city: Fredericton
country: Canada
facility: Brunswick Dermatology Center /ID# 264260
state: New Brunswick
city: St. John's
country: Canada
facility: Karma Clinical Trials /ID# 265962
state: Newfoundland and Labrador
city: Cobourg
country: Canada
facility: Skin Health /ID# 267735
state: Ontario
city: Hamilton
country: Canada
facility: Leader Research /ID# 266114
state: Ontario
city: London
country: Canada
facility: DermEffects /ID# 265262
state: Ontario
city: Mississauga
country: Canada
facility: Derm Care Clinic /ID# 265261
state: Ontario
city: Richmond Hill
country: Canada
facility: York Dermatology Clinic & Research Centre /ID# 265265
state: Ontario
city: Toronto
country: Canada
facility: FACET Dermatology /ID# 265267
state: Ontario
city: Waterloo
country: Canada
facility: Private Practice - Dr. Kim Papp Clinical Research /ID# 265266
state: Ontario
city: Québec
country: Canada
facility: Centre de Recherche Saint-Louis /ID# 265855
state: Quebec
city: St-Jérôme
country: Canada
facility: Private Practice - Dr. Angelique Gagne-Henley /ID# 264263
state: Quebec
city: Saskatoon
country: Canada
facility: SkinSense Dermatology /ID# 265964
state: Saskatchewan
city: Quebec
country: Canada
facility: Diex Recherche Quebec Inc. /ID# 265263
city: Osijek
country: Croatia
facility: Klinicki bolnicki centar Osijek /ID# 265916
state: Osjecko-baranjska Zupanija
city: Rijeka
country: Croatia
facility: Specialty hospital Medico /ID# 263922
city: Ostrava
country: Czechia
facility: Fakultní nemocnice Ostrava /ID# 264041
state: Ostrava-mesto
city: Karlovy Vary
country: Czechia
facility: Karlovarska Krajska Nemocnice - Karlovy Vary /ID# 265354
city: Hellerup
country: Denmark
facility: Herlev and Gentofte Hospital /ID# 265839
state: Hovedstaden
city: Aarhus
country: Denmark
facility: Aarhus Universitetshospital - Skejby /ID# 265657
state: Midtjylland
city: Lyon
country: France
facility: Hopital Edouard Herriot /ID# 263456
state: Auvergne-Rhone-Alpes
city: St-Priest-en-Jarez
country: France
facility: Centre Hospitalier Universitaire de Saint Etienne - Hopital Nord /ID# 263459
state: Loire
city: Martigues
country: France
facility: Cabinet medical - Le bateau Blanc /ID# 263465
state: Provence-Alpes-Cote-d Azur
city: Rouen
country: France
facility: Centre Hospitalier Universitaire de Rouen (CHU)- Hopital Charles Nicolle /ID# 263995
state: Seine-Maritime
city: Paris
country: France
facility: Groupe Hospitalier Paris Saint-Joseph /ID# 263996
city: Reims
country: France
facility: Polyclinique Courlancy /ID# 263313
city: Freiburg
country: Germany
facility: Universitaetsklinikum Freiburg /ID# 263659
state: Baden-Wuerttemberg
city: Tübingen
country: Germany
facility: Universitaetsklinikum Tuebingen /ID# 271718
state: Baden-Wuerttemberg
city: Erlangen
country: Germany
facility: Universitaetsklinikum Erlangen /ID# 263075
state: Bayern
city: Memmingen
country: Germany
facility: Beldio Research GmbH /ID# 263074
state: Bayern
city: Darmstadt
country: Germany
facility: Rosenpark Research /ID# 269202
state: Hessen
city: Bad Bentheim
country: Germany
facility: Fachklinik Bad Bentheim /ID# 263067
state: Niedersachsen
city: Bochum
country: Germany
facility: Katholisches Klinikum Bochum /ID# 262976
state: Nordrhein-Westfalen
city: Muenster
country: Germany
facility: Universitaetsklinikum Muenster /ID# 263068
state: Nordrhein-Westfalen
city: Remscheid
country: Germany
facility: Hautarztpraxis Mortazawi /ID# 271673
state: Nordrhein-Westfalen
city: Mainz
country: Germany
facility: Hautarztpraxis Dr. Kirschner /ID# 263656
state: Rheinland-Pfalz
city: Berlin
country: Germany
facility: Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 263076
city: Athens
country: Greece
facility: University General Hospital Attikon /ID# 263413
state: Attiki
city: Athens
country: Greece
facility: General Hospital Andreas Syggros /ID# 263417
state: Attiki
city: Thessaloniki
country: Greece
facility: Hospital of Skin and Venereal Diseases- Thessaloniki /ID# 263416
city: Thessaloniki
country: Greece
facility: Papageorgiou General Hospital /ID# 263415
city: Guatemala City
country: Guatemala
facility: Dermos S.A. /ID# 265857
city: Guatemala
country: Guatemala
facility: Prosalud /Id# 266586
city: Debrecen
country: Hungary
facility: Debreceni Egyetem-Klinikai Kozpont /ID# 263423
state: Hajdu-Bihar
city: Kaposvár
country: Hungary
facility: Somogy Varmegyei Kaposi Mor Oktato Korhaz /ID# 263424
state: Somogy
city: Budapest
country: Hungary
facility: Semmelweis Egyetem /ID# 263451
city: Pécs
country: Hungary
facility: Pécsi Tudományegyetem /ID# 264120
city: Drogheda
country: Ireland
facility: Our Lady of Lourdes Hospital - Drogheda /ID# 265893
state: Louth
city: Cork
country: Ireland
facility: South Infirmary Victoria University Hospital /ID# 265872
city: Dublin
country: Ireland
facility: University College Dublin /ID# 265875
city: Dublin
country: Ireland
facility: Mater Misericordiae University Hospital /ID# 265914
city: Afula
country: Israel
facility: HaEmek Medical Center /ID# 267297
state: H_efa
city: Haifa
country: Israel
facility: Rambam Health Care Campus /ID# 262994
state: H_efa
city: Petah Tikva
country: Israel
facility: Rabin Medical Center /ID# 262992
state: HaMerkaz
city: Naharia
country: Israel
facility: Galilee Medical Center /ID# 262995
state: HaTsafon
city: Ramat Gan
country: Israel
facility: The Chaim Sheba Medical Center /ID# 262993
state: Tel-Aviv
city: Tel Aviv
country: Israel
facility: Tel Aviv Sourasky Medical Center /ID# 266581
state: Tel-Aviv
city: Jerusalem
country: Israel
facility: Hadassah Medical Center-Hebrew University /ID# 262884
city: Florence
country: Italy
facility: AZIENDA USL TOSCANA CENTRO - Ospedale Piero Palagi /ID# 263454
state: Firenze
city: Rozzano
country: Italy
facility: IRCCS Istituto Clinico Humanitas /ID# 263503
state: Lombardia
city: Naples
country: Italy
facility: Azienda Ospedaliera Universitaria Federico II /ID# 263539
state: Napoli
city: Rome
country: Italy
facility: Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Università Cattolica /ID# 263473
state: Roma
city: Catania
country: Italy
facility: AOU Policlinico G. Rodolico - San Marco /ID# 263469
city: Milano
country: Italy
facility: Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico /ID# 263471
city: Nagoya
country: Japan
facility: Nagoya City University Hospital /ID# 263874
state: Aichi
city: Toyoake
country: Japan
facility: Fujita Health University Hospital /ID# 265440
state: Aichi
city: Obihiro-Shi
country: Japan
facility: Takagi Dermatological Clinic /ID# 264810
state: Hokkaido
city: Morioka
country: Japan
facility: Iwate Medical University Uchimaru Medical Center /ID# 273799
state: Iwate
city: Kyoto-shi
country: Japan
facility: University Hospital Kyoto Prefectural University of Medicine /ID# 264291
state: Kyoto
city: Ginowan-shi
country: Japan
facility: University of the Ryukyus Hospital /ID# 264605
state: Okinawa
city: Osaka sayama-shi
country: Japan
facility: Kindai University Hospital /ID# 264322
state: Osaka
city: Osaka-shi
country: Japan
facility: Osaka Metropolitan University Hospital /ID# 265682
state: Osaka
city: Koshigaya
country: Japan
facility: Dokkyo Medical University Saitama Medical Center /ID# 265400
state: Saitama
city: Fukuoka
country: Japan
facility: Fukuoka University Hospital /ID# 263991
city: Tokyo
country: Japan
facility: Nihon University Itabashi Hospital /ID# 264661
city: Busan
country: Korea, Republic of
facility: Pusan National University Hospital /ID# 271496
state: Busan Gwang Yeogsi
city: Cheonan-si
country: Korea, Republic of
facility: SoonChunHyang University Hospital Cheonan /ID# 271320
state: Chungcheongnamdo
city: Ansan-si
country: Korea, Republic of
facility: Korea University Ansan Hospital /ID# 264227
state: Gyeonggido
city: Seongnam
country: Korea, Republic of
facility: CHA Bundang Medical Center /ID# 264225
state: Gyeonggido
city: Seoul
country: Korea, Republic of
facility: Yonsei University Health System Severance Hospital /ID# 271353
state: Seoul Teugbyeolsi
city: Seoul
country: Korea, Republic of
facility: SoonChunHyang University Seoul Hospital /ID# 264224
state: Seoul Teugbyeolsi
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center /ID# 264228
state: Seoul Teugbyeolsi
city: Seoul
country: Korea, Republic of
facility: Hallym University Kangnam Sacred Heart Hospital /ID# 264226
state: Seoul Teugbyeolsi
city: Monterrey
country: Mexico
facility: Eukarya PharmaSite /ID# 265307
state: Nuevo Leon
city: Rotterdam
country: Netherlands
facility: Erasmus Medisch Centrum /ID# 263377
state: Zuid-Holland
city: Hamilton
country: New Zealand
facility: Clinical Trials New Zealand /ID# 265432
state: Waikato
city: Auckland
country: New Zealand
facility: Greenlane Clinical Centre /ID# 263191
city: Stavanger
country: Norway
facility: Stavanger Universitetssykehus /ID# 265997
state: Rogaland
city: Tromsø
country: Norway
facility: Universitetssykehuset I Nord-Norge /ID# 265992
state: Troms
city: Oslo
country: Norway
facility: Oslo University Hospital - Rikshospitalet /ID# 265996
city: Bydgoszcz
country: Poland
facility: Oftalmika sp. z o.o. /ID# 263087
state: Kujawsko-pomorskie
city: Lodz
country: Poland
facility: DERMED Centrum Medyczne Sp. z o.o /ID# 263147
state: Lodzkie
city: Lodz
country: Poland
facility: Santa Sp. z o..o. Santa Familia PTG Lodz /ID# 263181
state: Lodzkie
city: Krakow
country: Poland
facility: Centrum Nowoczesnych Terapii 'Dobry Lekarz' sp.z.o.o. /ID# 263146
state: Malopolskie
city: Warszawa
country: Poland
facility: Klinika Ambroziak Dermatologia /ID# 263173
state: Mazowieckie
city: Guimaraes
country: Portugal
facility: Unidade Local de Saude do Alto Ave, EPE /ID# 265158
state: Braga
city: Lisbon
country: Portugal
facility: CUF Descobertas Hospital /ID# 263188
state: Lisboa
city: Lisboa
country: Portugal
facility: Unidade Local de Saude de Sao Jose, EPE /ID# 265155
city: Porto
country: Portugal
facility: Unidade Local de Saude de Santo Antonio, E.P.E. /ID# 265479
city: Carolina
country: Puerto Rico
facility: Private Practice - Dr. Alma Cruz /ID# 263204
city: San Juan
country: Puerto Rico
facility: Clinical Research Puerto Rico /ID# 263450
city: Bucharest
country: Romania
facility: Spitalul Clinic Colentina /ID# 263303
state: Bucuresti
city: Cluj Napoca
country: Romania
facility: Private Practice - Dr. Orasan Remus /ID# 263305
state: Cluj
city: Bucharest
country: Romania
facility: Centrul Medical Euromed /ID# 263304
city: Jeddah
country: Saudi Arabia
facility: King Abdulaziz Medical City /ID# 266121
state: Makkah
city: Riyadh
country: Saudi Arabia
facility: King Saud University Med City /ID# 266120
city: Belgrade
country: Serbia
facility: Military Medical Academy /ID# 263257
state: Beograd
city: Belgrade
country: Serbia
facility: University Clinical Center Serbia /ID# 263256
state: Beograd
city: Kragujevac
country: Serbia
facility: University Clinical Center Kragujevac /ID# 264211
state: Sumadijski Okrug
city: Novi Sad
country: Serbia
facility: University Clinical Center Vojvodina /ID# 263260
city: Singapore
country: Singapore
facility: National University Hospital /ID# 264673
city: Singapore
country: Singapore
facility: National Skin Centre /ID# 264680
city: Košice
country: Slovakia
facility: Univerzitna nemocnica L. Pasteura Kosice /ID# 263907
state: Kosicky Kraj
city: Nové Zámky
country: Slovakia
facility: Fakultna nemocnica s poliklinikou Nove Zamky /ID# 265944
state: Nitriansky Kraj
city: Bratislava
country: Slovakia
facility: Poliklinika Bezrucova (Cliniq s.r.o.) /ID# 263921
city: Trnava
country: Slovakia
facility: Fakultna nemocnica Trnava /ID# 263905
city: Ljubljana
country: Slovenia
facility: University Medical Centre Ljubljana /ID# 265720
city: Maribor
country: Slovenia
facility: University Medical Centre Maribor /ID# 265827
city: Pretoria
country: South Africa
facility: Global Clinical Trials /ID# 262839
state: Gauteng
city: Chatsworth
country: South Africa
facility: Life Chatsmed Garden Hospital /ID# 270237
state: Kwazulu-Natal
city: Durban
country: South Africa
facility: Ahmed Al-Kadi Private Hospital /ID# 262837
state: Kwazulu-Natal
city: Westville
country: South Africa
facility: Dr Ahmed Ismail Manjra /ID# 262838
state: Kwazulu-Natal
city: Sabadell
country: Spain
facility: Hospital Universitari Parc Tauli /ID# 262942
state: Barcelona
city: Santander
country: Spain
facility: Hospital Universitario Marqués de Valdecilla /ID# 263039
state: Cantabria
city: Málaga
country: Spain
facility: Hospital Universitario Virgen de la Victoria /ID# 262941
state: Malaga
city: Manises
country: Spain
facility: Hospital de Manises /ID# 262938
state: Valencia
city: Madrid
country: Spain
facility: Hospital General Universitario Gregorio Marañón /ID# 262940
city: Valencia
country: Spain
facility: Consorci Hospital General Universitario de Valencia /ID# 262944
city: Solna
country: Sweden
facility: Karolinska University Hospital Solna /ID# 264530
state: Stockholms Lan
city: Örebro
country: Sweden
facility: Universitetssjukhuset Örebro /ID# 265064
city: Buochs
country: Switzerland
facility: Dermatology & Skin Care Clinic /ID# 264030
state: Nidwalden
city: St. Gallen
country: Switzerland
facility: Kantonsspital St.Gallen /ID# 264238
state: Sankt Gallen
city: Zurich
country: Switzerland
facility: University Hospital Zurich /ID# 266142
state: Zuerich
city: Kaohsiung City
country: Taiwan
facility: Kaohsiung Chang Gung Memorial Hospital /ID# 264619
state: Kaohsiung
city: Taipei City
country: Taiwan
facility: National Taiwan University Hospital /ID# 264618
state: Taipei
city: Taichung
country: Taiwan
facility: Taichung Veterans General Hospital /ID# 270741
city: Taipei City
country: Taiwan
facility: Mackay Memorial Hospital /ID# 263661
city: Taipei City
country: Taiwan
facility: Taipei Veterans General Hospital /ID# 265879
city: Taoyuan City
country: Taiwan
facility: Linkou Chang Gung Memorial Hospital /ID# 264620
city: Dunfermline
country: United Kingdom
facility: Queen Margaret Hospital /ID# 264198
state: Fife
city: Gloucester
country: United Kingdom
facility: Gloucestershire Royal Hospital /ID# 265848
state: Gloucestershire
city: London
country: United Kingdom
facility: Disc_Barts Health NHS Trust - The Royal London Hospital /ID# 264121
state: Greater London
city: Harrogate
country: United Kingdom
facility: Harrogate District Hospital /ID# 265632
state: North Yorkshire
city: Bristol
country: United Kingdom
facility: Bristol Royal Infirmary /ID# 263937
Study officials:
affiliation: AbbVie
name: ABBVIE INC.
role: STUDY_DIRECTOR
References: