Clinical trial NCT04975997: Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Participants With Relapsed or Refractory Multiple Myeloma (RRMM)
Official title: A Phase 3, Two-Stage, Randomized, Multicenter, Open-label Study Comparing Iberdomide, Daratumumab and Dexamethasone (IberDd) Versus Daratumumab, Bortezomib, and Dexamethasone (DVd) in Subjects With Relapsed or Refractory Multiple Myeloma (RRMM)
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE3
Conditions: Multiple Myeloma
Keywords: Iberdomide
CC-220
Daratumumab
Darzalex Faspro
Bortezomib
Velcade
Dexamethasone
MM
Multiple Myeloma
RRMM
CELMoD
Cereblon Modulators
Lead sponsor: Celgene
Sponsor class: INDUSTRY
First posted: 2021-07-26
Enrollment: 864
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This is a multicenter, two-stage, randomized, controlled, open-label, Phase 3 study comparing the efficacy and safety of iberdomide in combination with dexamethasone and daratumumab (IberDd) versus daratumumab, bortezomib, and dexamethasone (DVd) in participants with relapsed or refractory multiple myeloma (RRMM).

Detailed description: This is a multicenter, two-stage, randomized, controlled, open-label, Phase 3 study comparing the efficacy and safety of iberdomide in combination with dexamethasone and daratumumab (IberDd) versus daratumumab, bortezomib, and dexamethasone (DVd) in participants with relapsed or refractory multiple myeloma (RRMM). Approximately 200 patients randomized in stage 1 to one of three iberdomide dose levels of 1, 1.3, or 1.6 mg in combination with daratumumab and dexamethasone (Treatment Arms A1, A2, or A3), or to the DVd comparator arm (Treatment Arm B).

In Stage 2 of the study, approximately 664 additional subjects will be randomized 1:1 between 2 treatment arms:

* Approximately 332 subjects will be randomized to receive Treatment Arm A (IberDd)
* Approximately 332 subjects will be randomized to receive Treatment Arm B (DVd)

Participants in both treatment arms will continue to receive treatment until confirmed progressive disease (PD), unacceptable toxicity or withdrawal of consent. To ensure accuracy and completeness of the primary endpoint assessment of progression-free survival (PFS), participants who permanently discontinue study treatment for any reason, other than confirmed PD or withdrawal of consent, will continue to be followed for disease assessment.

The study will be conducted in compliance with International Council for Harmonisation (ICH) and Good Clinical Practices (GCPs).

Eligibility criteria: Inclusion Criteria

* Documented diagnosis of multiple myeloma (MM) and measurable disease.
* Received 1 to 2 prior lines of anti-myeloma therapy.
* Must have documented disease progression during or after their last anti-myeloma regimen.
* Eastern Cooperative Oncology Group (ECOG) performance status score of 0, 1 or 2.

Exclusion Criteria

* Any condition that confounds the ability to interpret data from the study.
* Has plasma cell leukemia, Waldenstrom's macroglobulinemia or POEMS syndrome (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein, and skin changes), or clinically significant amyloidosis.
* Known central nervous system involvement with MM.
* Prior therapy with iberdomide.
* Other protocol-defined Inclusion/Exclusion criteria apply.

Primary outcomes:
measure: Progression-free Survival (PFS)
timeFrame: Up to approximately 5 years
measure: Minimal Residual Disease (MRD) negative Complete Response (CR) at any time
timeFrame: Up to approximately 5 years
Secondary outcomes:
measure: Overall Survival (OS)
timeFrame: Up to approximately 5 years
measure: Sustainability of Minimal Residual Disease (MRD) negativity
timeFrame: Up to approximately 5 years
measure: Overall Response Rate (ORR)
timeFrame: Up to approximately 5 years
measure: Time to response (TTR)
timeFrame: Up to approximately 5 years
measure: Duration of Response (DoR)
timeFrame: Up to approximately 5 years
measure: Time to Progression (TTP)
timeFrame: Up to approximately 5 years
measure: Time to Next Treatment (TTNT)
timeFrame: Up to approximately 5 years
measure: Progression-free Survival 2 (PFS2)
timeFrame: Up to approximately 5 years
measure: Safety
timeFrame: Up to approximately 5 years
measure: European Organization for Research and Treatment of Cancer - Quality of Life C30 Questionnaire (EORTC QLQ-C30)
timeFrame: Up to approximately 5 years
measure: European Quality of Life Multiple Myeloma Module (EORTC QLQ-MY20)
timeFrame: Up to approximately 5 years
measure: Recommended iberdomide dose for Stage 2
timeFrame: Up to approximately 1 year
measure: Area under the plasma concentration-time curve from time zero to tau (AUC(TAU))
timeFrame: Up to approximately 1 year
measure: Maximum plasma concentration (Cmax)
timeFrame: Up to approximately 1 year
measure: Time to maximum plasma concentration (Tmax)
timeFrame: Up to approximately 1 year
Other outcomes:
Locations:
city: Hot Springs
country: United States
facility: Local Institution - 035
state: Arkansas
city: Cerritos
country: United States
facility: The Oncology Institute Of Hope And Innovation
state: California
city: Corona
country: United States
facility: Local Institution - 683
state: California
city: Fountain Valley
country: United States
facility: Los Angeles Cancer Network - Fountain Valley
state: California
city: Los Angeles
country: United States
facility: USC Norris Comprehensive Cancer Center
state: California
city: Newport
country: United States
facility: USC Norris Comprehensive Cancer Center
state: California
city: New Haven
country: United States
facility: Yale University School Of Medicine
state: Connecticut
city: Fort Myers
country: United States
facility: Local Institution - 029
state: Florida
city: Jacksonville
country: United States
facility: Local Institution - 049
state: Florida
city: Ocala
country: United States
facility: Ocala Oncology Center
state: Florida
city: Saint Petersburg
country: United States
facility: Local Institution - 028
state: Florida
city: Tamarac
country: United States
facility: BRCR Global
state: Florida
city: West Palm Beach
country: United States
facility: Local Institution - 034
state: Florida
city: Weston
country: United States
facility: Cleveland Clinic Florida
state: Florida
city: Atlanta
country: United States
facility: Emory University School of Medicine
state: Georgia
city: Elk Grove Village
country: United States
facility: Alexian Brothers Hospital Network
state: Illinois
city: Urbana
country: United States
facility: Local Institution - 689
state: Illinois
city: Dyer
country: United States
facility: Northwest Cancer Center
state: Indiana
city: Louisville
country: United States
facility: Norton Cancer Institute - St. Matthews Campus
state: Kentucky
city: Alexandria
country: United States
facility: Local Institution - 041
state: Louisiana
city: Baton Rouge
country: United States
facility: Our Lady of the Lake Cancer Institute
state: Louisiana
city: Baton Rouge
country: United States
facility: Local Institution - 027
state: Louisiana
city: New Orleans
country: United States
facility: Local Institution - 696
state: Louisiana
city: Baltimore
country: United States
facility: Greater Baltimore Medical Center
state: Maryland
city: Bethesda
country: United States
facility: Center For Cancer And Blood Disorders
state: Maryland
city: Columbia
country: United States
facility: Maryland Oncology Hematology (Columbia) - USOR
state: Maryland
city: Boston
country: United States
facility: Dana Farber Cancer Institute
state: Massachusetts
city: Worcester
country: United States
facility: University of Massachusetts Memorial Medical Center
state: Massachusetts
city: Burnsville
country: United States
facility: Minnesota Oncology Hematology, P.A. - Burnsville
state: Minnesota
city: Kansas City
country: United States
facility: Local Institution - 694
state: Missouri
city: Kansas City
country: United States
facility: HCA Midwest Health
state: Missouri
city: Billings
country: United States
facility: Intermountain Health St. Vincent Regional Hospital - Cancer Centers of Montana
state: Montana
city: Summit
country: United States
facility: Local Institution - 015
state: New Jersey
city: Bay Shore
country: United States
facility: Local Institution - 042
state: New York
city: New York
country: United States
facility: Manhattan Hematology Oncology Center
state: New York
city: Durham
country: United States
facility: Duke University Hospital
state: North Carolina
city: Cincinnati
country: United States
facility: TriHealth, Good Samaritan Hospital
state: Ohio
city: Cincinnati
country: United States
facility: Local Institution - 644
state: Ohio
city: Cleveland
country: United States
facility: Local Institution - 037
state: Ohio
city: Cleveland
country: United States
facility: Cleveland Clinic - Taussig Cancer Institute
state: Ohio
city: Columbus
country: United States
facility: Ohio Health Corporation
state: Ohio
city: Tulsa
country: United States
facility: Oklahoma Cancer Specialists and Research Institute
state: Oklahoma
city: Portland
country: United States
facility: Oregon Health and Science University
state: Oregon
city: Hershey
country: United States
facility: Local Institution - 048
state: Pennsylvania
city: Chattanooga
country: United States
facility: Tennessee Oncology
state: Tennessee
city: Nashville
country: United States
facility: Tennessee Oncology - Nashville
state: Tennessee
city: Austin
country: United States
facility: Texas Oncology-Austin Midtown
state: Texas
city: Houston
country: United States
facility: Kelsey Seybold Clinic Berthelsen Main Campus
state: Texas
city: Houston
country: United States
facility: Local Institution - 690
state: Texas
city: Newport News
country: United States
facility: USOR - Virginia Oncology Associates - Newport News
state: Virginia
city: Roanoke
country: United States
facility: Blue Ridge Cancer Care
state: Virginia
city: Vancouver
country: United States
facility: Local Institution - 646
state: Washington
city: Madison
country: United States
facility: University Of Wisconsin
state: Wisconsin
city: Ciudad Autanoma De Buenos Aires
country: Argentina
facility: Local Institution - 080
state: Buenos Aires
city: Villa Elisa
country: Argentina
facility: Local Institution - 083
state: Buenos Aires
city: Birtinya
country: Australia
facility: Local Institution - 813
state: Queensland
city: Douglas
country: Australia
facility: Local Institution - 812
state: Queensland
city: Adelaide
country: Australia
facility: Local Institution - 803
state: South Australia
city: Bedford Park
country: Australia
facility: Local Institution - 806
state: South Australia
city: Clayton
country: Australia
facility: Local Institution - 802
state: Victoria
city: East Melbourne
country: Australia
facility: Local Institution - 809
state: Victoria
city: Melbourne
country: Australia
facility: Local Institution - 801
state: Victoria
city: Murdoch
country: Australia
facility: Local Institution - 811
state: Western Australia
city: West Perth
country: Australia
facility: Local Institution - 807
state: Western Australia
city: Camperdown
country: Australia
facility: Local Institution - 804
city: Fitzroy
country: Australia
facility: Local Institution - 800
city: Garran
country: Australia
facility: Local Institution - 808
city: Graz
country: Austria
facility: Local Institution - 155
city: Linz
country: Austria
facility: Local Institution - 154
city: Salzburg
country: Austria
facility: Local Institution - 153
city: St Polten
country: Austria
facility: Local Institution - 156
city: Vienna
country: Austria
facility: Local Institution - 150
city: Wien
country: Austria
facility: Local Institution - 151
city: Wien
country: Austria
facility: Local Institution - 157
city: Brugge
country: Belgium
facility: Local Institution - 172
city: Bruxelles
country: Belgium
facility: Local Institution - 174
city: Curitiba
country: Brazil
facility: Local Institution - 056
state: Parana
city: Porto Alegre
country: Brazil
facility: Local Institution - 058
state: RIO Grande DO SUL
city: Porto Alegre
country: Brazil
facility: Local Institution - 050
state: RS
city: Jau
country: Brazil
facility: Local Institution - 054
state: SAO Paulo
city: Sao Paulo
country: Brazil
facility: Local Institution - 055
state: SP
city: Barretos
country: Brazil
facility: Local Institution - 051
state: São Paulo
city: Rio de Janeiro
country: Brazil
facility: Local Institution - 053
city: Sao Paulo
country: Brazil
facility: Local Institution - 057
city: Sao Paulo
country: Brazil
facility: Local Institution - 052
city: Calgary
country: Canada
facility: Local Institution - 111
state: Alberta
city: Edmonton
country: Canada
facility: Local Institution - 103
state: Alberta
city: Surrey
country: Canada
facility: Local Institution - 112
state: British Columbia
city: Saint John
country: Canada
facility: Local Institution - 104
state: New Brunswick
city: St John's
country: Canada
facility: Local Institution - 110
state: Newfoundland and Labrador
city: Halifax
country: Canada
facility: Local Institution - 101
state: Nova Scotia
city: Ottawa
country: Canada
facility: Local Institution - 109
state: Quebec
city: Saskatoon
country: Canada
facility: Local Institution - 107
state: Saskatchewan
city: Quebec
country: Canada
facility: Local Institution - 108
city: Changsha
country: China
facility: Local Institution - 141
state: Hunan
city: Nanchang
country: China
facility: Local Institution - 129
state: Jiangxi
city: Xian
country: China
facility: Local Institution - 143
state: Shaanxi
city: Shanghai
country: China
facility: Local Institution - 142
state: Shanghai
city: Taiyuan
country: China
facility: Local Institution - 145
state: Shanxi
city: Wenzhou
country: China
facility: Local Institution - 144
state: Zhejiang
city: Beijing
country: China
facility: Local Institution - 140
city: Beijing
country: China
facility: Local Institution - 139
city: Beijing
country: China
facility: Local Institution - 138
city: Changchun
country: China
facility: Local Institution - 126
city: Chaoyang District
country: China
facility: Local Institution - 121
city: Guangzhou
country: China
facility: Local Institution - 135
city: Guangzhou
country: China
facility: Local Institution - 136
city: Hangzhou City
country: China
facility: Local Institution - 128
city: Hangzhou, Zhejiang
country: China
facility: Local Institution - 120
city: Harbin
country: China
facility: Local Institution - 127
city: Nanjing
country: China
facility: Local Institution - 134
city: Shanghai
country: China
facility: Local Institution - 132
city: Shanghai
country: China
facility: Local Institution - 130
city: Shenyang
country: China
facility: Local Institution - 131
city: Suzhu
country: China
facility: Local Institution - 124
city: Tianjin
country: China
facility: Local Institution - 133
city: Wuhan
country: China
facility: Local Institution - 137
city: Xian
country: China
facility: Local Institution - 125
city: Zhengzhou
country: China
facility: Local Institution - 123
city: Brno
country: Czechia
facility: Local Institution - 601
city: Ostrava-Poruba
country: Czechia
facility: Local Institution - 600
city: Prague 2
country: Czechia
facility: Local Institution - 602
city: Aalborg
country: Denmark
facility: Local Institution - 371
city: Odense
country: Denmark
facility: Local Institution - 370
city: Roskilde
country: Denmark
facility: Local Institution - 372
city: Turku
country: Finland
facility: Local Institution - 231
state: Varsinais-Suomi
city: Helsinki
country: Finland
facility: Local Institution - 230
city: Oulu
country: Finland
facility: Local Institution - 232
city: Argenteuil
country: France
facility: Local Institution - 463
city: La Roche -Sur-Yon - Cedex 9
country: France
facility: Local Institution - 462
city: Lille Cedex
country: France
facility: Local Institution - 451
city: Nancy Cedex
country: France
facility: Local Institution - 458
city: Nantes
country: France
facility: Local Institution - 454
city: Paris Cedex
country: France
facility: Local Institution - 452
city: Paris
country: France
facility: Local Institution - 456
city: Pessac
country: France
facility: Local Institution - 464
city: Rouen
country: France
facility: Local Institution - 465
city: Toulouse Cedex 9
country: France
facility: Local Institution - 457
city: Kiel
country: Germany
facility: Local Institution - 308
state: Schleswig-Holstein
city: Frankfurt am Main
country: Germany
facility: Local Institution - 301
city: Hamburg
country: Germany
facility: Local Institution - 300
city: Hamburg
country: Germany
facility: Local Institution - 302
city: Heidelberg
country: Germany
facility: Local Institution - 305
city: Lubeck
country: Germany
facility: Local Institution - 304
city: Patras
country: Greece
facility: Local Institution - 573
state: Achaea
city: Patra
country: Greece
facility: Local Institution - 574
state: Achaia
city: Athens
country: Greece
facility: Local Institution - 571
city: Thessaloniki
country: Greece
facility: Local Institution - 572
city: Thessaloniki
country: Greece
facility: Local Institution - 570
city: Hyderabad
country: India
facility: Local Institution - 932
state: Andhra Pradesh
city: Bangalore
country: India
facility: Local Institution - 930
state: Karnataka
city: Ernakulam
country: India
facility: Local Institution - 934
state: Kerala
city: Mumbai
country: India
facility: Local Institution - 933
state: Maharashtra
city: Kolkata
country: India
facility: Local Institution - 935
state: West Bengal
city: Pondicherry
country: India
facility: Local Institution - 931
city: Cork
country: Ireland
facility: Local Institution - 752
city: Dublin 9
country: Ireland
facility: Local Institution - 750
city: Galway
country: Ireland
facility: Local Institution - 751
city: Afula
country: Israel
facility: Local Institution - 874
state: HaZafon
city: Haifa
country: Israel
facility: Local Institution - 872
city: Jerusalem
country: Israel
facility: Local Institution - 871
city: Tel Aviv
country: Israel
facility: Local Institution - 870
city: Tel Hashomer
country: Israel
facility: Local Institution - 873
city: Roma
country: Italy
facility: Local Institution - 415
state: Lazio
city: Bologna
country: Italy
facility: Local Institution - 400
city: Catania
country: Italy
facility: Local Institution - 408
city: Genova
country: Italy
facility: Local Institution - 414
city: Milano
country: Italy
facility: Local Institution - 404
city: Milano
country: Italy
facility: Local Institution - 407
city: Novara
country: Italy
facility: Local Institution - 410
city: Pavia
country: Italy
facility: Local Institution - 412
city: Pisa
country: Italy
facility: Local Institution - 402
city: Reggio Calabria
country: Italy
facility: Local Institution - 405
city: Reggio Emilia
country: Italy
facility: Local Institution - 413
city: Roma
country: Italy
facility: Local Institution - 401
city: San Giovanni Rotondo FG
country: Italy
facility: Local Institution - 403
city: Terni
country: Italy
facility: Local Institution - 409
city: Udine
country: Italy
facility: Local Institution - 406
city: Matsuyama
country: Japan
facility: Local Institution - 900
state: Ehime
city: Higashi-Ibaraki-gun
country: Japan
facility: Local Institution - 917
state: Ibaraki
city: Shimotsuga
country: Japan
facility: Local Institution - 919
state: Tochigi
city: Nerima-ku
country: Japan
facility: Local Institution - 920
state: Tokyo
city: Shinagawa-ku
country: Japan
facility: Local Institution - 918
state: Tokyo
city: Chuo-shi
country: Japan
facility: Local Institution - 915
state: Yamanashi
city: Aomori
country: Japan
facility: Local Institution - 912
city: Chiba
country: Japan
facility: Local Institution - 916
city: Fukuoka
country: Japan
facility: Local Institution - 911
city: Kamogawa
country: Japan
facility: Local Institution - 903
city: Kyoto-City
country: Japan
facility: Local Institution - 902
city: Nagoya
country: Japan
facility: Local Institution - 910
city: Nagoya
country: Japan
facility: Local Institution - 901
city: Okayama
country: Japan
facility: Local Institution - 905
city: Osaka-Sayama
country: Japan
facility: Local Institution - 908
city: Osaka
country: Japan
facility: Local Institution - 907
city: Sapporo
country: Japan
facility: Local Institution - 913
city: Sendai
country: Japan
facility: Local Institution - 914
city: Shibuya-ku
country: Japan
facility: Local Institution - 906
city: Shinagawa-ku, Tokyo
country: Japan
facility: Local Institution - 909
city: Toyohashi
country: Japan
facility: Local Institution - 904
city: Daegu
country: Korea, Republic of
facility: Local Institution - 974
city: Gyeonggi-do
country: Korea, Republic of
facility: Local Institution - 973
city: Hwasun-gun
country: Korea, Republic of
facility: Local Institution - 975
city: Seoul
country: Korea, Republic of
facility: Local Institution - 971
city: Seoul
country: Korea, Republic of
facility: Local Institution - 976
city: Seoul
country: Korea, Republic of
facility: Local Institution - 972
city: Seoul
country: Korea, Republic of
facility: Local Institution - 970
city: Seoul
country: Korea, Republic of
facility: Local Institution - 977
city: Mexico City
country: Mexico
facility: Local Institution - 182
state: Distrito Federal
city: Guadalajara
country: Mexico
facility: Local Institution - 183
state: Jalisco
city: La Raza
country: Mexico
facility: Local Institution - 181
city: Mexico City
country: Mexico
facility: Local Institution - 180
city: Dordrecht
country: Netherlands
facility: Local Institution - 351
state: Zuid-Holland
city: Amsterdam
country: Netherlands
facility: Local Institution - 354
city: Den Haag
country: Netherlands
facility: Local Institution - 352
city: Bergen
country: Norway
facility: Local Institution - 202
city: Oslo
country: Norway
facility: Local Institution - 200
city: Trondheim
country: Norway
facility: Local Institution - 201
city: Bialystok
country: Poland
facility: Local Institution - 631
state: Podlaskie
city: Krakow
country: Poland
facility: Local Institution - 633
city: Nowy Sacz
country: Poland
facility: Local Institution - 635
city: Poznan
country: Poland
facility: Local Institution - 634
city: Walbrzych
country: Poland
facility: Local Institution - 636
city: Warszawa
country: Poland
facility: Local Institution - 630
city: Coimbra
country: Portugal
facility: Local Institution - 545
city: Lisboa
country: Portugal
facility: Local Institution - 543
city: Lisboa
country: Portugal
facility: Local Institution - 544
city: Porto
country: Portugal
facility: Local Institution - 540
city: Porto
country: Portugal
facility: Local Institution - 541
city: Pretoria
country: South Africa
facility: Local Institution - 791
state: Gauteng
city: Cape Town
country: South Africa
facility: Local Institution - 790
state: Western Cape
city: Kuils River
country: South Africa
facility: Local Institution - 792
state: Western Cape
city: Pamplona
country: Spain
facility: Local Institution - 514
state: Navarra
city: Barcelona
country: Spain
facility: Local Institution - 505
city: Barcelona
country: Spain
facility: Local Institution - 502
city: Barcelona
country: Spain
facility: Local Institution - 511
city: Caceres
country: Spain
facility: Local Institution - 501
city: Cordoba
country: Spain
facility: Local Institution - 509
city: Madrid
country: Spain
facility: Local Institution - 510
city: Madrid
country: Spain
facility: Local Institution - 516
city: Madrid
country: Spain
facility: Local Institution - 504
city: Madrid
country: Spain
facility: Local Institution - 513
city: Malaga
country: Spain
facility: Local Institution - 503
city: Murcia
country: Spain
facility: Local Institution - 508
city: Oviedo
country: Spain
facility: Local Institution - 506
city: Salamanca
country: Spain
facility: Local Institution - 515
city: Santiago de Compostela
country: Spain
facility: Local Institution - 500
city: Valencia
country: Spain
facility: Local Institution - 512
city: Zaragoza
country: Spain
facility: Local Institution - 507
city: Boras
country: Sweden
facility: Local Institution - 272
city: Helsingborg
country: Sweden
facility: Local Institution - 271
city: Chur
country: Switzerland
facility: Local Institution - 851
city: St. Gallen
country: Switzerland
facility: Local Institution - 850
city: Niao-Sung Hsiang Kaohsiung County
country: Taiwan
facility: Local Institution - 955
city: Taichung City
country: Taiwan
facility: Local Institution - 952
city: Taichung
country: Taiwan
facility: Local Institution - 954
city: Tainan, Taiana
country: Taiwan
facility: Local Institution - 951
city: Taipei, Zhongzheng Dist.
country: Taiwan
facility: Local Institution - 956
city: Taipei
country: Taiwan
facility: Local Institution - 950
city: Taoyuan City
country: Taiwan
facility: Local Institution - 953
city: Kavaklıdere
country: Turkey
facility: Local Institution - 778
state: Ankara
city: Yenimahalle
country: Turkey
facility: Local Institution - 776
state: Ankara
city: Pendik
country: Turkey
facility: Local Institution - 777
state: Istanbul
city: Balçova
country: Turkey
facility: Local Institution - 771
state: Izmir
city: Bornova
country: Turkey
facility: Local Institution - 775
state: Izmir
city: Samsun
country: Turkey
facility: Local Institution - 773
state: Kurupelit
city: Ankara
country: Turkey
facility: Local Institution - 770
city: Gaziantep
country: Turkey
facility: Local Institution - 772
city: Kayseri
country: Turkey
facility: Local Institution - 774
city: Nottingham
country: United Kingdom
facility: Local Institution - 702
state: Nottinghamshire
city: Belfast Northern Ireland
country: United Kingdom
facility: Local Institution - 705
city: Birmingham
country: United Kingdom
facility: Local Institution - 700
city: Canterbury Kent
country: United Kingdom
facility: Local Institution - 707
city: Lancashire Blackpool
country: United Kingdom
facility: Local Institution - 704
city: London
country: United Kingdom
facility: Local Institution - 701
city: London
country: United Kingdom
facility: Local Institution - 709
city: Oxford
country: United Kingdom
facility: Local Institution - 706
city: Portsmouth
country: United Kingdom
facility: Local Institution - 711
city: Sutton
country: United Kingdom
facility: Local Institution - 713
city: Wolverhampton
country: United Kingdom
facility: Local Institution - 708
Study officials:
affiliation: Bristol-Myers Squibb
name: Bristol-Myers Squibb
role: STUDY_DIRECTOR
References: