Clinical trial NCT04810897: Effects of Home-based Exercise in Parkinson's Disease
Official title: Effects of Home-based Exercise Programme in Individuals With Parkinson's Disease
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Parkinson Disease
Keywords: Exercise
Gait characteristics
Lead sponsor: Mahidol University
Sponsor class: OTHER
First posted: 2021-03-23
Enrollment: 20
Sex: ALL
Minimum age (years): 60
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Individuals with Parkinson's disease (PD) who refers from a public hospital and recruits from community.

Brief summary: Home-based exercise program focusing on axial rigidity could be used as an adjunct rehabilitation program to improve rotational movement, gait and functional movement associated with axial rigidity in individuals with PD.

Detailed description: Typically, individuals with PD revert to more primitive movement patterns, which lack many of the automatic postural adjustments and axial movements that accompany simple activities, such as supine to standing, getting up from sitting or turning over in bed. The present study is designed to allow patients and their relatives to perform exercises by themselves conveniently at home. The results were considered a vital component of a complex intervention and were played an integral part in the implementation process of exercises in functional performance. Furthermore, this study will prove sufficient high-quality evidence to investigate whether improvements in function due to exercise-based rehabilitation are associated with reducing axial rigidity in individuals with PD.

Currently, there is a lack of evidence for the effectiveness of home-based exercise programs in PD patients in Thailand. For the present study, we devised a home-based 10-week exercise program focusing on segmental rotation and task-specific movements for turning practice to determine effects on axial mobility and turning. The aimed of this study to examine the effects of a 10-week task specific home-based exercise program on turning kinematics, gait and stepping characteristics, the Functional Reach test (FRT), the Unified Parkinson's Disease Rating Scale (UPDRS), the Freezing of Gait questionnaire (FOG) and the Fall Efficacy Scale International (FES-I) in individuals with PD.

Eligibility criteria: 1. Inclusion Criteria;

   * Clinically diagnosed with PD stages 1.5 to 3 as assessed by the modified Hoehn and Yahr scale
   * The age groups between 50 and 75 years
   * Taking PD medication regularly for at least a month
   * No signs of wearing-off phenomenon
   * Able to walk independently without any assistive device and 6) able to follow commands and instructions
2. Exclusion Criteria;

   * Clinically diagnosed with dementia or other neurological or cardiopulmonary diseases
   * Musculoskeletal problems that could influence the test performance such as arthritis or severe leg pain
   * High blood pressure (more than 140/90 mmHg)
   * Haemodialysis
   * Visual problems that could not be adjusted with lenses or glasses
   * Taking medicine which affected to functional movement.

Primary outcomes:
measure: The Unified Parkinson's Disease Rating Scale (UPDRS),
timeFrame: 3 months
measure: Functional axial rotation - physical (FAR)
timeFrame: 3 months
measure: Gait and turning characteristics
timeFrame: 3 months
Secondary outcomes:
measure: Time Up and Go
timeFrame: 3 months
measure: 10 Meter walk test
timeFrame: 3 months
measure: Global rating scale (GROC)
timeFrame: 3 months
Other outcomes:
Locations:
city: Nakhon Pathom
country: Thailand
facility: Fuengfa Khobkhun
Study officials:
affiliation: Physical Therapy
name: Fuengfa Khobkhun
role: PRINCIPAL_INVESTIGATOR
References: