Clinical trial NCT04758897: Clinical Study of VG161 in Subjects With Advanced Malignant Solid Tumors
Official title: A Dose Ascending, Open Phase I Clinical Study to Evaluate the Safety, Tolerability and Pharmacokinetics Characteristics of VG161 in Subjects With Advanced Malignant Solid Tumors
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
Conditions: Advanced Malignant Solid Tumor
Keywords: Solid Tumor
Lead sponsor: CNBG-Virogin Biotech (Shanghai) Ltd.
Sponsor class: INDUSTRY
First posted: 2021-02-17
Enrollment: 18
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: VG161 is a recombinant human-IL12/15/PDL1B oncolytic HSV-1 Injectable. This Phase I study will be conducted in HSV-seropositive subjects with advanced malignant solid tumors that are refractory to conventional therapies. This is an open label study to determine the safety and tolerability of VG161, and recommended dose of VG161 for Phase II trials.

Detailed description: The trial will be conducted in 7 dose ascending cohorts, including 3 single dose accelerated titration design pilots and 4 multiple dose escalation groups.

Descriptive statistics will be used to summarize all data.

Eligibility criteria: Inclusion Criteria:

1. Males or females aged within 18 to 80 years.
2. Subject with late stage carcinoma which is refractory/relapsed after and/or intolerant of standard therapies or for which no standard therapy exists.
3. There is at lease one injectable tumor lesion that meet the requirements of the assigned dose level. The superficial lesions are preferred, and the deep lesions that can be injected under the guidance of B ultrasound or computed tomography (CT) scan can also be selected.
4. Eastern Cooperative Oncology Group (ECOG) scores 0 or 1.
5. Life expectancy is at least 3 months.
6. Required organ function:

1) Hematology blood (no blood transfusion or colony stimulating factor treatment within 14 days): Absolute neutrophil count (ANC)≥1.5×10\^9L, Platelets ( PLT)≥75×10\^9L, hemoglobin (Hb)≥85g/L; 2) Liver function: Total Serum bilirubin (TBIL)≤1.5×ULN (the upper limit of the reference range), Alanine aminotransferase (ALT)≤3×ULN, aspartate aminotransferase (AST)≤3×ULN (acceptable for patients with liver metastasis or liver cancer: TBIL≤5×ULN, AST≤5×ULN, ALT≤5×ULN); 3) Renal function: Serum creatinine≤1.5×ULN, and creatinine clearance≥50 ml/min (calculated per Cockcroft-Gault formula); 4) Coagulation function: activated partial thromboplastin time (APTT)≤1.5×ULN, international standardized ratio (INR)≤1.5×ULN.

7. Subjects of childbearing potential (male and female) must agree to use a reliable contraceptive method (hormone or barrier method or abstinence) during the study and for at least 90 days following the last dose; females of childbearing potential must have a negative blood or urine pregnancy test within 7 days of study enrollment.

8. Signed written informed consent.

Exclusion Criteria:

1. Subject in prior anti-tumor therapies such as chemotherapy, radiotherapy, biotherapy, endocrinotherapy, targeted therapy, immunotherapy within 4 weeks of study treatment initiation.
2. Participation in clinical trials of any other investigational agents within 4 weeks of study treatment initiation.
3. Major organ surgery (excluding puncture biopsy) or significant trauma within 4 weeks of study treatment initiation.
4. Patients who received systemic treatment with either corticosteroids ( \>10 mg/ daily prednisone or equivalent) or other immunosuppressive medications within 14 days of study treatment initiation.
5. Subjects with any ≥Grade 1 toxicity (as per NCI CTC AE Version 5.0) related to prior anti-cancer therapy (except for toxicity that the investigator assessed to be no safety risk, such as alopecia.).
6. Subjects with any uncontrolled active Central Nervous System (CNS) metastasis or meningeal metastasis with clinical symptoms.
7. Seronegative for Herpes Simplex Virus (HSV) (HSV-1IgG and HSV-1IgM).
8. Subjects with the relapse of HSV infection and relevant clinical manifestations, such as lip herpes, herpes keratitis, herpes dermatitis, and genital herpes.
9. Subjects with other uncontrolled active infections.
10. Known history of immunodeficiency and test positive of human immunodeficiency virus (HIV).
11. Active infection of hepatitis B (HBV) (hepatitis b virus titer higher than the detection limit or those requiring antiviral therapy), or hepatitis C virus (HCV).
12. History of severe cardiovascular disease:

1)Ventricular arrhythmias requiring clinical intervention; 2)QTc interval \>480 ms; 3)Acute coronary syndrome, congestive heart failure, stroke or other cardiovascular events of III grade or above within 6 months; 4)The cardiac function grade≥II or left ventricular ejection fraction (LVEF) \<50% per the New York Heart Association (NYA); 5)Uncontrolled hypertension. 13. Subjects with active or past autoimmune diseases that are likely to recur (e.g. systemic lupus erythematosus, rheumatoid arthritis, vasculitis, etc.); acceptable for patients with clinically stable autoimmune thyroiditis.

14. Subjects with any prior ≥Grade 3 immune-related adverse event (irAE) while receiving any previous immunotherapy agent.

15. known to have alcohol or drug dependence. 16. Persons with mental disorders or poor compliance. 17. Pregnant or lactating women. 18. Subjects with any significant unrelated systemic illness that to the investigator's opinion would compromise the subject's eligibility to participate the study.

Primary outcomes:
measure: MTD/RP2D
timeFrame: 1 month
measure: Occurence of DLT
timeFrame: 1 month
measure: Numbers of DLT
timeFrame: 1 month
measure: Occurence of AE and SAE（NCI CTCAE 5.0）
timeFrame: 7 months
measure: Frequency of AE and SAE（NCI CTCAE 5.0）
timeFrame: 7 months
Secondary outcomes:
measure: Tmax(h)
timeFrame: At the end of Cycle 1 (each cycle is 28 days)
measure: Cmax(copies/ugDNA)
timeFrame: At the end of Cycle 1 (each cycle is 28 days)
measure: ORR
timeFrame: 7 months
measure: DCR
timeFrame: 7 months
measure: mPFS
timeFrame: 7 months
measure: CD3+, CD4+, CD8+
timeFrame: 7 months
measure: IL15
timeFrame: 7 months
measure: PD-L1, PD-1
timeFrame: 7 months
measure: Existence of Biomarkers
timeFrame: 4 months
Other outcomes:
Locations:
city: ShangHai
country: China
facility: ShangHai East hospital
state: Shanghai
city: ShangHai
country: China
facility: Xin Hua Hospital Affiliated to ShangHai Jiao Tong University School of Medicine
state: Shanghai
Study officials:
affiliation: Shanghai East Hospital
name: Jin Li, doctor
role: PRINCIPAL_INVESTIGATOR
References: