Clinical trial NCT06509087: The Combined Utility of Angio-CT and MRI in Managing Chronic Musculoskeletal Pain: a Prospective Study to Evaluate the Efficacy of Transarterial Microembolization
Official title: The Combined Utility of Angio-CT and MRI in Managing Chronic Musculoskeletal Pain: a Prospective Study to Evaluate the Efficacy of Transarterial Microembolization
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Chronic Musculoskeletal Disease
Transarterial Embolization
Magnetic Resonance Imaging
Angiography
Computed Tomography
Lead sponsor: Tri-Service General Hospital
Sponsor class: OTHER
First posted: 2024-07-19
Enrollment: 60
Sex: ALL
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with chronic musculoskeletal shoulder or knee joint pain who undergo preoperative magnetic resonance imaging (MRI) and receive transarterial microembolization (TAME) performed using fused computed tomography (CT) and angiography systems.

Brief summary: Transarterial microembolization (TAME) is a novel treatment option for chronic musculoskeletal pain, especially suitable for patients who have not responded to conservative treatment or are unsuitable for surgical procedures. This minimally invasive technique primarily targets abnormal neovascularization for embolization, relying heavily on precise information provided by various imaging techniques to ensure the effectiveness and safety of the treatment. This study aims to explore the application of integrating preoperative magnetic resonance imaging (MRI) evidence of patient pain and intraoperative high-resolution synchronous imaging information from fused computed tomography (CT) and angiography systems. This integration is intended to enhance preoperative planning, intraoperative guidance, and final treatment outcome assessment, focusing on its crucial contribution to treatment success. It is hoped that this approach will provide pain intervention physicians with reliable diagnostic tools and safe treatment methods, thereby improving treatment outcomes for patients with chronic musculoskeletal pain.


Eligibility criteria: Inclusion Criteria:

* Patients with chronic musculoskeletal shoulder or knee joint pain in our hospital, including degenerative knee arthritis, adhesive capsulitis of the shoulder, and those confirmed by physical examination or ultrasound-guided injection to have tendinopathy or ligamentopathy, who have failed drug therapy, rehabilitation, or injection treatments, with a duration of symptoms greater than three months, are the target population of this study.

Exclusion Criteria:

* Pregnancy, coagulation disorders, symptoms of relevant local infections or tumors, and patients allergic to contrast agents. Patients must have complete medical records; those who do not meet the inclusion criteria will be excluded.

Primary outcomes:
measure: Pain relief
timeFrame: day 0, day 1, week 1, month 1, month 3, and month 6.
Secondary outcomes:
measure: Functional improvement (for shoulder joint)
timeFrame: day 0, day 1, week 1, month 1, month 3, and month 6.
measure: Functional improvement (for knee joint)
timeFrame: day 0, day 1, week 1, month 1, month 3, and month 6.
Other outcomes:
measure: The technical success rate of TAME procedure
timeFrame: Immediately after the TAME procedure
Locations:
city: Taipei
country: Taiwan
facility: Tri-Service General Hospital
Study officials:
affiliation: Tri-Service General Hospital, National Defense Medical Center
name: Yi-Chih Hsu, M.D.
role: PRINCIPAL_INVESTIGATOR
References: