Clinical trial NCT02457000: Sleep, Circadian Rhythm & Skin Health
Official title: Sleep, Circadian Rhythm & Skin Health
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Healthy
Psoriasis
Eczema
Acne
Keywords: Sleep
Skin
Circadian Rhythm
Lead sponsor: University Hospitals Cleveland Medical Center
Sponsor class: OTHER
First posted: 2015-05-29
Enrollment: 59
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: OTHER
Sampling method: PROBABILITY_SAMPLE
Study population: Adults from Northeast Ohio who are either healthy, normal volunteers or have skin pathology including but not limited to eczema, psoriasis, acne, and other inflammatory dermatoses

Brief summary: The purpose of this study is to explore the mechanisms behind how sleep quality may affect skin aging, skin integrity and skin disease.


Eligibility criteria: Inclusion Criteria:

* Males or females ages 18 years and above
* Capable of giving informed consent
* Adults who are either healthy, normal volunteers or those with a skin disease including but not limited to eczema, psoriasis, acne or other inflammatory dermatoses
* Fitzpatrick Skin Type I-VI
* In good general health
* Willing to cooperate with study instructions

Exclusion Criteria:

* Volunteers 18 years or younger
* Any serious medical or physical condition that would cause the subject significant discomfort with study procedures
* Women who are pregnant, nursing, or who may become pregnant in the next 3 months

Primary outcomes:
measure: Analysis of Sleep Pattern via Actigraphy, Polysomnography & Questionnaires
timeFrame: 7-14 days
measure: Evaluation of skin (both in terms of skin aging and skin disease)
timeFrame: Only once during the study or at specific time points depending on what other procedures are being performed
Secondary outcomes:
measure: Sample Analysis (from skin, blood, urine, saliva and hair follicle samples)
timeFrame: Only once during the study or at specific time points depending on what other procedures are being performed
measure: Skin Barrier Recovery (via TEWL measurement)
timeFrame: Only once during the study or at specific time points depending on what other procedures are being performed
measure: MED Testing & Recovery from UV-induced erythema
timeFrame: 24 hours
Other outcomes:
Locations:
city: Cleveland
country: United States
facility: University Hospitals Cleveland Medical Center
state: Ohio
Study officials:
affiliation: University Hospitals Cleveland Medical Center
name: Kevin Cooper, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Oyetakin-White P, Suggs A, Koo B, Matsui MS, Yarosh D, Cooper KD, Baron ED. Does poor sleep quality affect skin ageing? Clin Exp Dermatol. 2015 Jan;40(1):17-22. doi: 10.1111/ced.12455. Epub 2014 Sep 30.
citation: Rogiers V; EEMCO Group. EEMCO guidance for the assessment of transepidermal water loss in cosmetic sciences. Skin Pharmacol Appl Skin Physiol. 2001 Mar-Apr;14(2):117-28. doi: 10.1159/000056341.
citation: Vierkotter A, Ranft U, Kramer U, Sugiri D, Reimann V, Krutmann J. The SCINEXA: a novel, validated score to simultaneously assess and differentiate between intrinsic and extrinsic skin ageing. J Dermatol Sci. 2009 Mar;53(3):207-11. doi: 10.1016/j.jdermsci.2008.10.001. Epub 2008 Dec 6.