Clinical trial NCT02747056: Study of the Personal Identity in Adults With Autism Spectrum Disorder Without Intellectual Deficiency
Official title: Study of the Personal Identity in Adults With Autism Spectrum Disorder Without Intellectual Deficiency
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Autism Spectrum Disorders
Lead sponsor: University Hospital, Strasbourg, France
Sponsor class: OTHER
First posted: 2016-04-21
Enrollment: 102
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The research aims at clarifying the impact of autism on personal identity in adulthood. Two studies will be made in order to compare adults with autistic spectrum disorders without intellectual deficiency and controls. In the first study (Study A), the investigators will ask subjects to tell autobiographical memories and to specify their characteristics by answering focused questions. In the second study (Study B), the investigators will ask subjects to say the self statements which define them. Then, subjects will have to tell and to specify the characteristics of the autobiographical memories linked to these self statements.

Detailed description: Introduction:

Autism associates impairments in social relationships and specific competencies linked to restricted interests. These interests usually focus on mathematics, drawings or foreign language learning and are very significant in the autobiographies of persons with autism without intellectual deficiency. It's seem to be a basement of their self-identity. The personal identity relies on both the self representations and the sense of self. This sense of self supports the self continuity through time which links the present feelings, the autobiographical memories and the future personals projects. The personal identity depends on the memory of life events called "autobiographical memory."

Objectives:

The research aims at clarifying the impact of autism on personal identity in adulthood. Two studies will be made in order to compare adults with autistic spectrum disorders without intellectual deficiency and controls. In the first study (Study A), the investigators will ask subjects to tell autobiographical memories and to specify their characteristics by answering focused questions. In the second study (Study B), the investigators will ask subjects to say the self statements which define them. Then, subjects will have to tell and to specify the characteristics of the autobiographical memories linked to these self statements.

Expected Results:

The first study will inform the investigators on the sense of self and self continuity through time. The investigators predict that it would be difficult for subjects with autism spectrum disorders to give details of their life events. The focused questions should make easier the recollection of the memories. The investigators hypothesize that the memories linked to the typically autistic restricted interests would be more detailed.

The second study will inform the investigators on the memories linked to self representations. The investigators predict that these memories would be, in autism, less detailed and less important for identity. The investigators also hypothesize that the memories linked to the restricted interests would be more detailed and important for the self.

Autobiographical memory and socialization are deeply interconnected. So, the investigators think that this research will help them to elaborate news therapies focused on autobiographical memory improvement. Finally, the investigators want to reduce the social disability in autism.

Eligibility criteria: Study A \& B, Adults with autism spectrum disorders without intellectual deficiency

Inclusion criteria:

* adults with autism spectrum disorders
* 18 to 65 years old

Exclusion criteria:

* treatment with benzodiazepines

Study A \& B, control adults

Inclusion criteria:

* healthy volunteers
* 18 to 65 years old

Exclusion criteria:

* psychiatric disorders

Primary outcomes:
measure: The number of details in the memory (A)/The specificity of the memory (B)
timeFrame: The number of details or the specificity of the memory is assessed from 1 day to 3 months after the inclusion/baseline
Secondary outcomes:
measure: Study A and B: Autistic symptoms questionnaire 1
timeFrame: the Autistic symptoms will be assessed during the initiation/baseline visit at V1
measure: Study A and B: Autistic symptoms questionnaire 2
timeFrame: the Autistic symptoms will be assessed during the initiation/baseline visit at V1
measure: Study A and B: Autistic symptoms questionnaire 3
timeFrame: the Autistic symptoms will be assessed during the initiation/baseline visit at V1
measure: Study A and B:Executives functions, test 1
timeFrame: Executives functions will be assessed during the initiation/baseline visit (V1)
measure: Study Aand B:Executives functions test 2
timeFrame: Executives functions will be assessed during the initiation/baseline visit (V1)
measure: Study A and B:Executives functions test 3
timeFrame: Executives functions will be assessed during the initiation/baseline visit (V1)
measure: Study A and B: The self concept, questionnaire 1
timeFrame: self-concept will be assessed during the initiation/baseline visit (V1)
measure: Study A and B: The self concept, questionnaire 2
timeFrame: self-concept will be assessed during the initiation/baseline visit (V1)
measure: Study A and B: The self concept, questionnaire 3
timeFrame: self-concept will be assessed during the initiation/baseline visit (V1)
measure: Study A: the number of remember/ know/ guess responses, the perspective in recollection and the subjective temporal distance in the memory
timeFrame: This outcome will be assessed on the follow up visit (V2) either one day after the inclusion visit (V1) or within 3 months after V1
measure: Study B:The importance for the self of the memory test1
timeFrame: This outcome will be assessed on the follow up visit (V2) either one day after the inclusion visit (V1) or within 3 months after V1Description
measure: Study B:The importance for the self of the memory test 2
timeFrame: this outcome will be assessed on the follow up visit (V2) either one day after the inclusion visit (V1) or within 3 months after V1Description
measure: Study B:The importance for the self of the memory test 3
timeFrame: this outcome will be assessed on the follow up visit (V2) either one day after the inclusion visit (V1) or within 3 months after V1Description
measure: Study B:The importance for the self of the memory test 4
timeFrame: this outcome will be assessed on the follow up visit (V2) either one day after the inclusion visit (V1) or within 3 months after V1Description
Other outcomes:
Locations:
city: Strasbourg
country: France
facility: Hôpitaux universitaires de Strasbourg
Study officials:
affiliation: Hôpitaux Universitaires de Strasbourg
name: Jean Marie DANION, Prof
role: PRINCIPAL_INVESTIGATOR
References: