Clinical trial NCT05038111: Medical Records Investigation of Whether Perioperative Dexmedetomidine Will Reduce the Duration of Mechanical Ventilation or Hospital Length of Stay in Patients Undergoing Minimally Invasive Cardiac Surgery
Official title: Medical Records Investigation of Whether Perioperative Dexmedetomidine Will Reduce the Duration of Mechanical Ventilation or Hospital Length of Stay in Patients Undergoing Minimally Invasive Cardiac Surgery
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Mechanical Ventilation
Hospital Length of Stay
Minimally Invasive Cardiac Surgery
Keywords: mechanical ventilation
hospital length of stay
dexmedetomidine
Minimally Invasive Cardiac Surgery
Lead sponsor: Far Eastern Memorial Hospital
Sponsor class: OTHER
First posted: 2021-09-08
Enrollment: 81
Sex: ALL
Minimum age (years): 20
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients were eligible for inclusion if they had undergone minimal invasive off-pump coronary artery bypass graft (CABG), valvular surgery or combined procedures at Far Eastern Memorial Hospital, New Taipei City, Taiwan between January 1, 2020 and August 31, 2020. Additionally patients were included if they were aged 20 years or older and were excluded if it was emergency surgery, if they had postoperative mechanical ventilation more than 6 hours or if they were extubated in the operating room.

Brief summary: The concept of enhanced recovery after surgery (ERAS) is utilizing in multiple specialties widely. Early tracheal extubation is one of the components of ERAS that enhances postoperative recovery and reduces the length of stay in intensive care unit (ICU).Dexmedetomidine is a highly selective, shorter-acting α2-adrenergic receptor agonist that has both analgesic and sedativeeffects.It was associated with decreased mortality, time to extubation, and hospital length of stay in cardiac surgical patients according to previous studies.The purpose of this study was to investigate the effect of perioperative dexmedetomidine on patients undergoing minimally invasive cardiac surgery(MICS) who were early extubated after surgery.


Eligibility criteria: Inclusion Criteria:

* Patients undergone minimal invasive off-pump coronary artery bypass graft (CABG), valvular surgery or combined procedures at Far Eastern Memorial Hospital, New Taipei City, Taiwan between January 1, 2020 and August 31, 2020.
* Age above 20 y/o

Exclusion Criteria:

* Emergency surgery
* Postoperative mechanical ventilation more than 6 hours
* Extubated in the operating room

Primary outcomes:
measure: postoperative mechanical ventilation duration
timeFrame: up to 1 week
measure: ICU and hospital length of stay
timeFrame: through admission, up to 1 month
Secondary outcomes:
measure: postoperative complications
timeFrame: according to ICD 10 on medical record, daily to discharge, up to 1 month
Other outcomes:
Locations:
city: New Taipei City
country: Taiwan
facility: Far Eastern Memorial Hospital
Study officials:
affiliation: Far Eastern Memorial Hospital
name: Tsung-Hua Yang, MD
role: PRINCIPAL_INVESTIGATOR
References: