Clinical trial NCT01594333: Cardiovascular Inflammation Reduction Trial
Official title: A Randomized, Double-blind, Placebo-controlled, Event-driven Trial of Weekly Low-dose Methotrexate (LDM) in the Prevention of Cardiovascular Events Among Stable Coronary Artery Disease Patients With Type 2 Diabetes or Metabolic Syndrome
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Cardiovascular Disease
Keywords: Myocardial Infarction
Stroke
Cardiovascular death
Type 2 Diabetes
Metabolic Syndrome
Cardiovascular Inflammation
Atherothrombosis
Lead sponsor: Brigham and Women's Hospital
Sponsor class: OTHER
Collaborators: name: National Heart, Lung, and Blood Institute (NHLBI)
First posted: 2012-05-09
Enrollment: 4786
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The Cardiovascular Inflammation Reduction Trial (CIRT) is a randomized clinical trial investigating whether taking low-dose methotrexate reduces heart attacks, strokes, or death in people with type 2 diabetes or metabolic syndrome that have had a heart attack or multiple coronary blockages. This trial is funded by the National Heart, Lung, and Blood Institute (NHLBI)/National Institutes of Health (NIH).

Detailed description: While inflammation contributes crucially to atherothrombosis, it is unknown whether inhibition of inflammation per se will lower vascular event rates. The primary aim of the Cardiovascular Inflammation Reduction Trial (CIRT) is to directly test the inflammatory hypothesis of atherothrombosis by evaluating whether or not low-dose methotrexate (LDM) will reduce rates of myocardial infarction, stroke, and cardiovascular death among stable coronary artery disease patients with type 2 diabetes or metabolic syndrome, conditions associated with an enhanced pro-inflammatory response. CIRT is a randomized, double-blind, placebo-controlled, multi-center, event-driven trial that will randomize 7,000 men and women from the United States and Canada. Following a five- to six-week open-label run-in (maximum 8 weeks), eligible participants who have either suffered documented myocardial infarction in the past or have angiographically demonstrated multivessel coronary artery disease in the past will be randomly allocated over a three to four year period to usual care plus placebo or usual care plus LDM. The target methotrexate dose among those allocated to active therapy is 15 to 20 mg po per week, a dose within the range of that commonly used for the treatment of rheumatoid arthritis. All study participants will additionally receive 1.0 mg oral folate to be taken daily six days per week. LDM complications will be minimized through education programs for all investigators and coordinators, through enhanced communication with study participants, by limiting enrollment to those with no evidence of malignancy, hepatitis, renal dysfunction, chronic infection, pulmonary disease, or other risk factors for toxicity; by conducting an initial 5- to 6-week active-therapy run-in (maximum 8 weeks) designed to eliminate individuals who are either intolerant of or unable to adhere to treatment before randomization; and through regular monitoring of liver function and hematologic indices using a centralized methodology designed to ensure participant safety, allow for dose adjustments while maintaining the study blind, and provide an efficient method to address issues of compliance and follow-up on a cost-effective centralized basis. The primary trial endpoint is the rate of myocardial infarction, stroke, or cardiovascular death. Secondary and tertiary endpoints include all-cause mortality, coronary revascularization, incident congestive heart failure, incident peripheral artery disease, incident venous thrombosis, clinically significant aortic stenosis, incident atrial fibrillation, incident diabetes among those with metabolic syndrome but not diabetes at study entry, and hemoglobin A1c (HbA1c) control among those with diabetes at study entry. The trial is event driven such that in the absence of extreme effects, the trial will conclude after accrual of at least 530 primary endpoints, an effect estimated to provide 90 percent power to detect a 25 percent relative risk reduction. The potential clinical impact of CIRT is broad as it has sufficient power to directly address core issues in the inflammatory hypothesis of atherothrombosis, and thus, if successful, will open major new directions for cardiovascular treatment.

Eligibility criteria: Inclusion Criteria:

* Age ≥ 18 years at screening
* Documented past history of myocardial infarction OR past evidence of multivessel coronary artery disease by angiography.

  * To qualify on the basis of past history of myocardial infarction, the event must be documented either by hospital records or by evidence on current ECG of Q waves in two contiguous leads and/or an imaging test demonstrating wall motion abnormality or scar. The patient must also have completed any planned coronary revascularization procedures associated with the qualifying event, and be clinically stable for at least 60 days prior to screening.
  * To qualify on the basis of multivessel coronary disease, there must be past angiographic evidence of atherosclerosis in at least 2 major epicardial vessels defined either as the presence of a stent, a coronary bypass graft, or an angiographic lesion of 60% or greater. Left main coronary artery disease that has been revascularized with a stent or bypass graft will qualify as multivessel disease, as will the presence of a 50% or greater isolated left main stenosis. The patient must also have completed any planned coronary revascularization procedures associated with the qualifying event, and be clinically stable for at least 60 days prior to screening.
* History of type 2 diabetes or metabolic syndrome at time of study enrollment
* Willingness to participate as evidenced by signing the study informed consent

Exclusion Criteria:

* Prior history of chronic infectious disease, tuberculosis, or severe fungal disease; chronic hepatitis B or C infection; renal insufficiency; interstitial pneumonitis, bronchiectasis, or pulmonary fibrosis; known chronic pericardial effusion, pleural effusion, or ascites; chronic liver disease; myeloproliferative disorders in the past 5 years; non-basal cell malignancy or treated lymphoproliferative disease within the past 5 years; known HIV positive; life expectancy of \< 3 years;
* Chronic inflammatory condition such as lupus or rheumatoid arthritis, ulcerative colitis or Crohn's disease
* White blood cell count \< 3,500/ul, hematocrit \< 32 percent, or platelet count \< 75,000/ul
* Liver transaminase levels (AST or ALT) \>upper limit of normal (ULN) or albumin \< the lower limit of normal (LLN);
* Creatinine clearance \< 40 ml/min as estimated with the Cockcroft-Gault equation;
* History of alcohol abuse or unwillingness to limit alcohol consumption to less than 4 drinks per week
* Women of child bearing potential, even if they are currently using contraception, and women intending to breastfeed.
* Men who plan to father children during the study period or who are unwilling to use effective forms of contraception.
* Requirement for use of drugs that alter folate metabolism (trimethoprim/sulfamethoxazol) or reduce tubular excretion (probenecid) or known allergies to antibiotics making avoidance of trimethoprim impossible;
* Current indication for methotrexate therapy;
* Chronic use of oral steroid therapy or other immunosuppressive or biologic response modifiers. Eligible study participants will be encouraged to have up to date pneumococcal and influenza vaccinations as recommended based on their age and underlying medical conditions.
* Chest X-ray evidence in the past 12 months of interstitial pneumonitis, bronchiectasis, or pulmonary fibrosis. For participants who do not have a chest X-ray in the prior 12 months, a chest X-ray will be obtained at baseline as part of the study protocol.
* New York Heart Association Class IV congestive heart failure.

Primary outcomes:
measure: Number of Subjects With Major Adverse Cardiovascular Events
timeFrame: From randomization to trial end (April 2, 2018) up to a maximum of 5 years
measure: Number of Subjects With Major Adverse Cardiovascular Event or Hospitalization for Unstable Angina That Led to Urgent Coronary Revascularization
timeFrame: From randomization to trial end (April 2, 2018) - up to a maximum of 5 years
Secondary outcomes:
measure: Number of Subjects With All-cause Mortality
timeFrame: From randomization to the trial end (April 2, 2018) up to a maximum of 5 years
measure: Number of Subjects With Major Adverse Cardiovascular Event or Any Coronary Revascularization
timeFrame: From randomization to the trial end (April 2, 2018) - up to a maximum of 5 years
measure: Number of Subjects With Hospitalization for Congestive Heart Failure
timeFrame: From randomization to trial end (April 2, 2018) up to a maximum of 5 years
measure: Number of Subjects With Major Adverse Cardiovascular Event, Coronary Revascularization, Hospitalization for Congestive Heart Failure or All Cause Mortality
timeFrame: From randomization to trial end (April 2, 2018) up to a maximum of 5 years
measure: Number of Subjects With New Onset Type 2 Diabetes
timeFrame: From randomization to the trial end (April 2, 2018) - up to 5 years
Other outcomes:
measure: Number of Subjects With Hospitalization for Unstable Angina That Led to Unplanned Coronary Revascularization
timeFrame: From randomization to the trial end (April 2, 2018) up to 5 years
measure: Number of Subjects With Coronary Revascularization
timeFrame: From randomization to trial end (April 2, 2018) up to 5 years
measure: Number of Subjects With Peripheral Artery Disease
timeFrame: From randomization to the trial end (April 2, 2018) - up to 5 years
measure: Number of Subjects With Deep Vein Thrombosis or Pulmonary Embolism
timeFrame: From randomization to the trial end (April 2, 2018) - up to 5 years
measure: Number of Subjects With Aortic Stenosis
timeFrame: From randomization to the trial end (April 2, 2018) - up to 5 years
measure: Number of Subjects With Atrial Fibrillation
timeFrame: From randomization to the trial end (April 2, 2018) - up to 5 years
Locations:
city: Birmingham
country: United States
facility: University of Alabama at Birmingham
state: Alabama
city: Fort Payne
country: United States
facility: Appalachian Research Associates
state: Alabama
city: Guntersville
country: United States
facility: Avant Research Associates, LLC
state: Alabama
city: Huntsville
country: United States
facility: Saadat Ansari MD LLC
state: Alabama
city: Mobile
country: United States
facility: University of South Alabama: Division of Clinical Research
state: Alabama
city: Cottonwood
country: United States
facility: Heart Vascular of Northern Arizona
state: Arizona
city: Mesa
country: United States
facility: CardioVascular Associates of Mesa
state: Arizona
city: Phoenix
country: United States
facility: Arizona Arthritis & Rheumatology Research
state: Arizona
city: Scottsdale
country: United States
facility: Scottsdale Medical Imaging
state: Arizona
city: Scottsdale
country: United States
facility: The Heart Clinic
state: Arizona
city: Tucson
country: United States
facility: Pima Heart
state: Arizona
city: Tucson
country: United States
facility: Southern Arizona VA Health Care System
state: Arizona
city: Little Rock
country: United States
facility: Arkansas Cardiology
state: Arkansas
city: Little Rock
country: United States
facility: Arkansas Heart Hospital
state: Arkansas
city: Anaheim
country: United States
facility: Oracle Clinical Research, Inc.
state: California
city: Culver City
country: United States
facility: Medical Group of Culver City
state: California
city: Fairfield
country: United States
facility: Touro University California- Solano County Affiliated Clinics
state: California
city: Fresno
country: United States
facility: University Of California San Francisco
state: California
city: Fresno
country: United States
facility: VACCHCS
state: California
city: La Jolla
country: United States
facility: UCSD Sulpizio Cardiovascular Center
state: California
city: La Jolla
country: United States
facility: University Of California San Diego
state: California
city: La Quinta
country: United States
facility: Desert Medical Care & Wellness
state: California
city: Lancaster
country: United States
facility: Kumar Medical Corporation
state: California
city: Loma Linda
country: United States
facility: Loma Linda University Health
state: California
city: Loma Linda
country: United States
facility: VA Loma Linda Healthcare System
state: California
city: Long Beach
country: United States
facility: Long Beach Center for Clinical Research
state: California
city: Long Beach
country: United States
facility: Cardiovascular Innovation and Research
state: California
city: Los Alamitos
country: United States
facility: Los Alamitos Cardiovascular
state: California
city: Los Angeles
country: United States
facility: Faye Montegrande Md. Clinical Research
state: California
city: Los Angeles
country: United States
facility: Eastside Clinical Research Associates
state: California
city: Los Angeles
country: United States
facility: Salman Khan A. Medical Corporation
state: California
city: Los Angeles
country: United States
facility: University of Southern California
state: California
city: Los Angeles
country: United States
facility: West LA VA Medical Center
state: California
city: Mather
country: United States
facility: VA Northern California Health Care
state: California
city: Northridge
country: United States
facility: Valley Clinical Trials, Inc.
state: California
city: Orange
country: United States
facility: Orange County Heart Institute & Research
state: California
city: Orange
country: United States
facility: University of CA Irvine Medical Center
state: California
city: Oxnard
country: United States
facility: Diverse Research Solutions
state: California
city: Pasadena
country: United States
facility: Huntington Memorial Hospital
state: California
city: Salinas
country: United States
facility: Central Coast Cardiology
state: California
city: San Diego
country: United States
facility: Richard G. Friedman, MD
state: California
city: San Diego
country: United States
facility: Ritchken and First MDs
state: California
city: San Diego
country: United States
facility: Foundation for Cardiovascular Medicine
state: California
city: San Diego
country: United States
facility: San Diego Cardiac Center
state: California
city: San Diego
country: United States
facility: Veterans Affairs San Diego Healthcare System
state: California
city: San Francisco
country: United States
facility: UCSF at Zuckerberg SF General Hospital
state: California
city: Santa Ana
country: United States
facility: Coastal Heart Medical Group, Inc.
state: California
city: Santa Maria
country: United States
facility: Comprehensive Cardiovascular Care
state: California
city: Stockton
country: United States
facility: Pacific Heart and Vascular Medical Group
state: California
city: Thousand Oaks
country: United States
facility: Manoj D. Aswani M.D.
state: California
city: Vallejo
country: United States
facility: Touro University California- Solano Public Health Affiliated Clinics
state: California
city: Colorado Springs
country: United States
facility: Munni R. Selagamsetty, Md, Pc
state: Colorado
city: Denver
country: United States
facility: Vijay - Aurora Denver Cardiology
state: Colorado
city: Fort Collins
country: United States
facility: Colorado Health Medical Group Heart Center of the Rockies
state: Colorado
city: Fort Collins
country: United States
facility: Medical Center of the Rockies Research
state: Colorado
city: Parker
country: United States
facility: Unrein - Rocky Vista University Health Center
state: Colorado
city: Bridgeport
country: United States
facility: Connecticut Heart and Vascular Center
state: Connecticut
city: Bridgeport
country: United States
facility: Bridgeport Hospital
state: Connecticut
city: Newark
country: United States
facility: Cardiology Physicians/Red Clay Research
state: Delaware
city: Washington
country: United States
facility: Boisey Barnes MD, PC
state: District of Columbia
city: Washington
country: United States
facility: GWU Medical Faculty Associatin, Inc.
state: District of Columbia
city: Aventura
country: United States
facility: Pianko - Aventura Research Center, LLC
state: Florida
city: Boca Raton
country: United States
facility: North Ridge Heart Associates
state: Florida
city: Clearwater
country: United States
facility: St. Francis Medical Institute
state: Florida
city: Coral Gables
country: United States
facility: Gonzalez MD & Aswad MD Health Ser
state: Florida
city: Cutler Bay
country: United States
facility: American Research Institute, Inc.
state: Florida
city: Daytona Beach
country: United States
facility: Daytona Heart Group
state: Florida
city: DeLand
country: United States
facility: Daytona Heart Group
state: Florida
city: Delray Beach
country: United States
facility: Seidman Clinical Trials
state: Florida
city: Delray Beach
country: United States
facility: Steven Cohen MD
state: Florida
city: Doral
country: United States
facility: Infinite Clinical Research
state: Florida
city: Doral
country: United States
facility: International Research Partners, LLC
state: Florida
city: Doral
country: United States
facility: Medical Research Institute at Doral, Inc.
state: Florida
city: Eustis
country: United States
facility: Lake Internal Medicine Assocaties
state: Florida
city: Fort Lauderdale
country: United States
facility: Invesclinic
state: Florida
city: Fort Myers
country: United States
facility: Primary Care Associates
state: Florida
city: Fort Myers
country: United States
facility: Lee Physician Group
state: Florida
city: Gainesville
country: United States
facility: The Cardiac and Vascular Institute
state: Florida
city: Gainesville
country: United States
facility: University of Florida
state: Florida
city: Hialeah
country: United States
facility: Qway Research
state: Florida
city: Hialeah
country: United States
facility: State of the Art Research
state: Florida
city: Hialeah
country: United States
facility: Healing Touch C&C Research
state: Florida
city: Hialeah
country: United States
facility: Luzmed Clinical Research Institute
state: Florida
city: Hialeah
country: United States
facility: Viviana Perez MD Research & Cosmetics
state: Florida
city: Hialeah
country: United States
facility: Elite Cardiac Research Center LLC
state: Florida
city: Hialeah
country: United States
facility: Nova Clinical Research Clinic
state: Florida
city: Hialeah
country: United States
facility: Best Quality Research, Inc.
state: Florida
city: Hollywood
country: United States
facility: South Florida Research Solutions, LLC
state: Florida
city: Homestead
country: United States
facility: John Gutleber Medical Research Office
state: Florida
city: Jupiter
country: United States
facility: Cardiovascular Medical Associates of Palm Beach
state: Florida
city: Kissimmee
country: United States
facility: Hope Clinical Research
state: Florida
city: Kissimmee
country: United States
facility: SIH Research, LLC
state: Florida
city: Miami Lakes
country: United States
facility: Lakes Research, LLC
state: Florida
city: Miami Lakes
country: United States
facility: Veritas Research Corp.
state: Florida
city: Miami Springs
country: United States
facility: Ocean Blue Medical Research Center
state: Florida
city: Miami
country: United States
facility: Medical Research Center of Florida
state: Florida
city: Miami
country: United States
facility: LG Diagnostics, Inc.
state: Florida
city: Miami
country: United States
facility: St. Paul Medical Research Center, Inc.
state: Florida
city: Miami
country: United States
facility: Team Medical Research
state: Florida
city: Miami
country: United States
facility: Paradise Clinical Research, LLC
state: Florida
city: Miami
country: United States
facility: GAD Research Center
state: Florida
city: Miami
country: United States
facility: Innovation Research Institute, Inc.
state: Florida
city: Miami
country: United States
facility: Sanitas Research
state: Florida
city: Miami
country: United States
facility: Segui - Med Care Research
state: Florida
city: Miami
country: United States
facility: South Florida Research Group, LLC
state: Florida
city: Miami
country: United States
facility: Vista Health Research, LLC
state: Florida
city: Miami
country: United States
facility: D De La Vega MD Research Group
state: Florida
city: Naples
country: United States
facility: Southwest Florida Research, LLC
state: Florida
city: Orlando
country: United States
facility: Orlando Healthy Heart Institute
state: Florida
city: Palm Beach Gardens
country: United States
facility: Palm Beach Gardens Research Center, LLC
state: Florida
city: Pembroke Pines
country: United States
facility: Broward Research Center
state: Florida
city: Pembroke Pines
country: United States
facility: Pioneer Clinical Research
state: Florida
city: Pembroke Pines
country: United States
facility: Sandoval - Broward Research Center
state: Florida
city: Saint Petersburg
country: United States
facility: Bay Area Heart Center: 49th Street
state: Florida
city: Saint Petersburg
country: United States
facility: Bay Area Heart Center: 7th Avenue
state: Florida
city: Sweetwater
country: United States
facility: Lenus Research & Medical Group
state: Florida
city: Tamarac
country: United States
facility: DBC Research
state: Florida
city: Weeki Wachee
country: United States
facility: Asclepes Research Centers
state: Florida
city: Wesley Chapel
country: United States
facility: Gupta - Premier Heart and Vascular Center
state: Florida
city: Athens
country: United States
facility: Athens Regional Medical Center
state: Georgia
city: Atlanta
country: United States
facility: Atlanta Veterans Affairs Medical Center
state: Georgia
city: Atlanta
country: United States
facility: Laureate Medical Group at Northside
state: Georgia
city: Atlanta
country: United States
facility: Synergy Therapeutic Partners
state: Georgia
city: Atlanta
country: United States
facility: Northside Hospital
state: Georgia
city: Cumming
country: United States
facility: Atlanta Heart Specialists, LLC
state: Georgia
city: Dalton
country: United States
facility: Heart and Rhythm Specialists
state: Georgia
city: Dunwoody
country: United States
facility: Albert F. Johary MD, PC
state: Georgia
city: Riverdale
country: United States
facility: Infinite Clinical Trials
state: Georgia
city: Smyrna
country: United States
facility: Atlanta Vanguard Medical Associates
state: Georgia
city: Suwanee
country: United States
facility: Herman Clinical Research, LLC
state: Georgia
city: Tucker
country: United States
facility: Atlanta Heart Specialists, LLC
state: Georgia
city: Vidalia
country: United States
facility: Cardiology Associates of Vidalia, P.C.
state: Georgia
city: Honolulu
country: United States
facility: VA Pacific Islands Health Care System
state: Hawaii
city: Boise
country: United States
facility: St. Luke's Idaho Cardiology Associates
state: Idaho
city: Idaho Falls
country: United States
facility: Clinical Research Prime
state: Idaho
city: Arlington Heights
country: United States
facility: Northwest Heart Clinical Research
state: Illinois
city: Chicago
country: United States
facility: University of Chicago Medical Center
state: Illinois
city: Chicago
country: United States
facility: Advocate Med Group-Heart & Vascular Of Illinois
state: Illinois
city: Normal
country: United States
facility: Illinois Heart & Lung Research Center, SC
state: Illinois
city: North Chicago
country: United States
facility: Captain James A. Lovell Federal Health
state: Illinois
city: Olympia Fields
country: United States
facility: Specialty Physicians of Illinois, LLC
state: Illinois
city: Rock Island
country: United States
facility: Advanced CardioVascular Consultants
state: Illinois
city: Dyer
country: United States
facility: Cardiospecialists, LTD
state: Indiana
city: Evansville
country: United States
facility: Martin - Martin Family Practice and Research
state: Indiana
city: Indianapolis
country: United States
facility: Krannert Institute Of Cardiology
state: Indiana
city: Indianapolis
country: United States
facility: Community Hospital South
state: Indiana
city: Indianapolis
country: United States
facility: Indiana Heart Physicians
state: Indiana
city: Muncie
country: United States
facility: Medical Consultants, PC
state: Indiana
city: West Des Moines
country: United States
facility: Iowa Heart Center
state: Iowa
city: Overland Park
country: United States
facility: Stahl - Midwest Heart & Vascular Specialists
state: Kansas
city: Wichita
country: United States
facility: Professional Research Network of KS
state: Kansas
city: Wichita
country: United States
facility: Robert J. Dole VAMC
state: Kansas
city: Lexington
country: United States
facility: University of Kentucky
state: Kentucky
city: Louisville
country: United States
facility: Robley Rex VAMC
state: Kentucky
city: Louisville
country: United States
facility: Stoddard - University of Louisville
state: Kentucky
city: Louisville
country: United States
facility: Bays - L-MARC Research Center
state: Kentucky
city: Owensboro
country: United States
facility: Research Integrity LLC
state: Kentucky
city: Covington
country: United States
facility: Dorothy H. Banish, MD, APMC Study Group
state: Louisiana
city: Crowley
country: United States
facility: Avant Research Associates, LLC
state: Louisiana
city: Hammond
country: United States
facility: North Oaks Cardiology
state: Louisiana
city: Marrero
country: United States
facility: American Clinical Research, LLC
state: Louisiana
city: Natchitoches
country: United States
facility: Otis Barnum D.O.P.C.
state: Louisiana
city: New Orleans
country: United States
facility: Tulane University Office of Health Research
state: Louisiana
city: Shreveport
country: United States
facility: Veterans Affairs Medical Center Shreveport
state: Louisiana
city: Auburn
country: United States
facility: Maine Research Associates
state: Maine
city: Bangor
country: United States
facility: Paul A. Shapero, M.D.
state: Maine
city: Biddeford
country: United States
facility: Southern Maine Health Care
state: Maine
city: Portland
country: United States
facility: InterMed, PA
state: Maine
city: South Portland
country: United States
facility: Maine Medical Partners Maine Health Cardiology
state: Maine
city: Westbrook
country: United States
facility: Maine Centers for Healthcare
state: Maine
city: Baltimore
country: United States
facility: Sinai Center for Thrombosis Research
state: Maryland
city: Charlotte Hall
country: United States
facility: St. Mary's Medical Center
state: Maryland
city: Clinton
country: United States
facility: Calvert Memorial Hospital
state: Maryland
city: Prince Frederick
country: United States
facility: Shah Associates, MD, LLC
state: Maryland
city: Salisbury
country: United States
facility: Peninsula Cardiology Associates
state: Maryland
city: Towson
country: United States
facility: IRC Clinics
state: Maryland
city: Boston
country: United States
facility: Brigham and Women's Hospital
state: Massachusetts
city: Boston
country: United States
facility: St. Elizabeth's Medical Center
state: Massachusetts
city: Boston
country: United States
facility: MGH Cardiology
state: Massachusetts
city: Boston
country: United States
facility: Joslin Diabetes Center
state: Massachusetts
city: Burlington
country: United States
facility: Lahey Hospital and Medical Center
state: Massachusetts
city: Chelsea
country: United States
facility: Massachusetts General Hospital - Chelsea Health Care Center
state: Massachusetts
city: Haverhill
country: United States
facility: Pentucket Medical Associates, Inc.
state: Massachusetts
city: Leeds
country: United States
facility: VA Central Western Massachusetts Healthca
state: Massachusetts
city: Milton
country: United States
facility: South Shore Internal Medicine
state: Massachusetts
city: Peabody
country: United States
facility: Lahey Medical Center
state: Massachusetts
city: Salem
country: United States
facility: North Shore Cardiovascular Associates
state: Massachusetts
city: Worcester
country: United States
facility: Reliant Medical Group
state: Massachusetts
city: Alpena
country: United States
facility: Endeavor Medical Research
state: Michigan
city: Detroit
country: United States
facility: John D. Dingell Veterans Affairs Medical Center
state: Michigan
city: Detroit
country: United States
facility: Trace Research Group at Wayne State University
state: Michigan
city: Detroit
country: United States
facility: Henry Ford Hospital
state: Michigan
city: Flint
country: United States
facility: Flint Clinical Research
state: Michigan
city: Flint
country: United States
facility: Apex Medical Research MI, Inc.
state: Michigan
city: Garden City
country: United States
facility: Garden City Hospital
state: Michigan
city: Grand Blanc
country: United States
facility: Genesys Regional Medical Center
state: Michigan
city: Hamtramck
country: United States
facility: National Clinical LLC
state: Michigan
city: Rochester Hills
country: United States
facility: Academic Cardiology Associates PC
state: Michigan
city: Royal Oak
country: United States
facility: Beaumont Health Center
state: Michigan
city: Saginaw
country: United States
facility: Covenant Medical Center, Inc.
state: Michigan
city: Saginaw
country: United States
facility: Mid-Michigan Heart & Vascular Center
state: Michigan
city: Saint Cloud
country: United States
facility: Centra Care Heart & Vascular Center at St. Cloud Hospital
state: Minnesota
city: Saint Paul
country: United States
facility: United Heart and Vascular Clinic
state: Minnesota
city: Gulfport
country: United States
facility: Gulfside Clinical Research, LLC
state: Mississippi
city: Jackson
country: United States
facility: University of MS Medical Center
state: Mississippi
city: Port Gibson
country: United States
facility: David M. Headley M.D. PA Planters Clinic
state: Mississippi
city: Southaven
country: United States
facility: Stern Cardiovascular Foundation, Inc.
state: Mississippi
city: Bridgeton
country: United States
facility: Center for Advanced Medicine and Research LLC
state: Missouri
city: Columbia
country: United States
facility: Clinical Research Center University of Missouri
state: Missouri
city: Festus
country: United States
facility: Quantum Research LLC
state: Missouri
city: Independence
country: United States
facility: Midwest Cardiology Associates
state: Missouri
city: Joplin
country: United States
facility: Freeman Health System
state: Missouri
city: Kansas City
country: United States
facility: VA Medical Center Kansas City
state: Missouri
city: Osage Beach
country: United States
facility: Lake Regional Cardiovascular Institute
state: Missouri
city: Saint Louis
country: United States
facility: VA St. Louis Health Care System (VASTLHCS)
state: Missouri
city: Saint Louis
country: United States
facility: SLUCare Cardiology
state: Missouri
city: Saint Louis
country: United States
facility: Washington University
state: Missouri
city: Saint Louis
country: United States
facility: Clinical Investigators LLC
state: Missouri
city: Saint Louis
country: United States
facility: Consult and Research Associates
state: Missouri
city: Saint Peters
country: United States
facility: Center for Advanced Medicine and Research
state: Missouri
city: Springfield
country: United States
facility: CoxHealth: Wheeler Heart & Vascular Center
state: Missouri
city: Springfield
country: United States
facility: Mercy Medical Research Institute
state: Missouri
city: Great Falls
country: United States
facility: Great Falls Clinic Clinical Research Deptartment
state: Montana
city: Missoula
country: United States
facility: Cone - Montana Medical Research
state: Montana
city: La Vista
country: United States
facility: Barrett Clinic, P.C.
state: Nebraska
city: Omaha
country: United States
facility: Heart Consultants
state: Nebraska
city: Omaha
country: United States
facility: Alegent Creighton Health
state: Nebraska
city: Omaha
country: United States
facility: University of Nebraska Medical Center
state: Nebraska
city: Las Vegas
country: United States
facility: Internal Medicine Clinic
state: Nevada
city: Las Vegas
country: United States
facility: Red Rock Clinical Research, LLC
state: Nevada
city: Reno
country: United States
facility: Sierra Nevada Health Care System
state: Nevada
city: Reno
country: United States
facility: Renown Inst for Heart & Vasc Health
state: Nevada
city: Nashua
country: United States
facility: Lahey Cardiology
state: New Hampshire
city: Flanders
country: United States
facility: Family Health at Mount Olive
state: New Jersey
city: Hillsborough
country: United States
facility: Cardiocare
state: New Jersey
city: Linden
country: United States
facility: New Jersey Heart
state: New Jersey
city: Neptune
country: United States
facility: Jersey Shore University Medical Center
state: New Jersey
city: New Brunswick
country: United States
facility: Cardiovascular Institute
state: New Jersey
city: North Bergen
country: United States
facility: Palisade Medical Center
state: New Jersey
city: Ridgewood
country: United States
facility: The Valley Hospital
state: New Jersey
city: Robbinsville
country: United States
facility: Mercer Bucks Cardiology
state: New Jersey
city: Somerset
country: United States
facility: Cardio Metabolic Institute
state: New Jersey
city: Teaneck
country: United States
facility: Holy Name Medical Center, Inc.
state: New Jersey
city: Wayne
country: United States
facility: Total Cardiology Care, LLC
state: New Jersey
city: Westwood
country: United States
facility: Westwood Cardiology Associates
state: New Jersey
city: Albuquerque
country: United States
facility: Presbyterian Heart Group
state: New Mexico
city: Albany
country: United States
facility: Albany Medical College
state: New York
city: Albany
country: United States
facility: Albany Stratton VA Medical Center
state: New York
city: Bronx
country: United States
facility: Novel Research of New York, LLC
state: New York
city: Bronx
country: United States
facility: Montefiore Medical Center
state: New York
city: Brooklyn
country: United States
facility: Brown - SUNY Downstate Medical Center
state: New York
city: Buffalo
country: United States
facility: Buffalo Heart Group
state: New York
city: Cooperstown
country: United States
facility: Bassett Healthcare Network
state: New York
city: Cortlandt Manor
country: United States
facility: NYU Hudson Valley Cardiology
state: New York
city: Flushing
country: United States
facility: NYHQ
state: New York
city: Jamaica
country: United States
facility: Jamaica Hospital Medical Center
state: New York
city: Mineola
country: United States
facility: Long Island Heart Associates
state: New York
city: Mineola
country: United States
facility: Winthrop University Hospital
state: New York
city: New Hyde Park
country: United States
facility: Long Island Jewish Medical Center
state: New York
city: New Hyde Park
country: United States
facility: Queens Long Island Medical Group
state: New York
city: New York
country: United States
facility: Chinatown Cardiology, PC
state: New York
city: New York
country: United States
facility: Weill Cornell Medical College and NY Presbyterian
state: New York
city: New York
country: United States
facility: Mount Sinai School of Medicine
state: New York
city: North Massapequa
country: United States
facility: DiGiovanna Institute for Medical Education and Research
state: New York
city: Plattsburgh
country: United States
facility: Champlain Valley Physician Hospital
state: New York
city: Schenectady
country: United States
facility: Cardiology Associates of Schenectady
state: New York
city: Asheville
country: United States
facility: Clinical Study Center of Asheville
state: North Carolina
city: Charlotte
country: United States
facility: Metrolina Internal Medicine
state: North Carolina
city: Charlotte
country: United States
facility: Gaffney Health Services
state: North Carolina
city: Charlotte
country: United States
facility: Carolinas Research Center
state: North Carolina
city: Elizabeth City
country: United States
facility: Eastern Carolina Cardiovascular, PA
state: North Carolina
city: Greenville
country: United States
facility: Eastern Cardiology
state: North Carolina
city: Lenoir
country: United States
facility: Northside Clinical Research
state: North Carolina
city: Mooresville
country: United States
facility: Lake Shore Clinical Research, LLC.
state: North Carolina
city: Morehead City
country: United States
facility: Carteret Medical Group
state: North Carolina
city: Morganton
country: United States
facility: Cardiology Associates of Carolinas, PA
state: North Carolina
city: New Bern
country: United States
facility: Eastern Nephrology Associates, PLLC
state: North Carolina
city: Rocky Mount
country: United States
facility: Boice Willis Clinic
state: North Carolina
city: Sanford
country: United States
facility: Sanford Cardiology
state: North Carolina
city: Wilson
country: United States
facility: Natalie A. Doyle, MD, PA
state: North Carolina
city: Grand Forks
country: United States
facility: Altru Health System Rehab Center
state: North Dakota
city: Akron
country: United States
facility: Akron General Medical Center
state: Ohio
city: Athens
country: United States
facility: Ohio University Heritage College of Osteopathic Medicine
state: Ohio
city: Canton
country: United States
facility: Diabetes and Endocrinology Associates of Stark Cit
state: Ohio
city: Cincinnati
country: United States
facility: The Lindner Research Center
state: Ohio
city: Cleveland
country: United States
facility: Cleveland Clinic
state: Ohio
city: Columbus
country: United States
facility: Optimed Research, LTD
state: Ohio
city: Dayton
country: United States
facility: Dayton Heart Center
state: Ohio
city: Dayton
country: United States
facility: Dayton Veteran Affairs Medical Center
state: Ohio
city: Lancaster
country: United States
facility: Colonnade Medical Group
state: Ohio
city: Middletown
country: United States
facility: Middletown Cardiovascular Associates
state: Ohio
city: Toledo
country: United States
facility: Comprehensive Heart Care, Inc.
state: Ohio
city: Westerville
country: United States
facility: Mount Carmel Clinical Cardiovascular Care
state: Ohio
city: Westlake
country: United States
facility: Premier Physicians
state: Ohio
city: Wooster
country: United States
facility: Wooster Heart Group
state: Ohio
city: Lindsay
country: United States
facility: Unity Clinical Research
state: Oklahoma
city: Oklahoma City
country: United States
facility: COR Clinical Research, LLC
state: Oklahoma
city: Oklahoma City
country: United States
facility: Thadani - VA Medical Center Oklahoma City, OK
state: Oklahoma
city: Oklahoma City
country: United States
facility: Today Clinical Research
state: Oklahoma
city: Oklahoma City
country: United States
facility: Cardiovascular Health Clinic
state: Oklahoma
city: Tulsa
country: United States
facility: Oklahoma State University Center for Health Sciences
state: Oklahoma
city: Corvallis
country: United States
facility: Samaritan Health Services
state: Oregon
city: Medford
country: United States
facility: Southern Oregon Cardiology, LLC
state: Oregon
city: Portland
country: United States
facility: Oregon Health & Science University
state: Oregon
city: Abington
country: United States
facility: Center for Clinical Res. Abington Health
state: Pennsylvania
city: Bethlehem
country: United States
facility: St. Luke's University Hospital
state: Pennsylvania
city: Bristol
country: United States
facility: Renu-Ca Research Institute, Lower Bucks Hospital
state: Pennsylvania
city: Broomall
country: United States
facility: Main Line Health Center, Broomall
state: Pennsylvania
city: Camp Hill
country: United States
facility: Spirit Physician Services, Inc
state: Pennsylvania
city: Chambersburg
country: United States
facility: The Chambersburg Hospital
state: Pennsylvania
city: Doylestown
country: United States
facility: Central Bucks Cardiology
state: Pennsylvania
city: Duncansville
country: United States
facility: Altoona Center for Clinical Research
state: Pennsylvania
city: Ephrata
country: United States
facility: Heart Specialists of Lancaster County
state: Pennsylvania
city: Erie
country: United States
facility: Saint Vincent Consultants in Cardiovascular Diseases, LLC
state: Pennsylvania
city: Feasterville
country: United States
facility: Feasterville Family Healthcare Center
state: Pennsylvania
city: Glen Mills
country: United States
facility: Christiana Care Health System
state: Pennsylvania
city: Harrisburg
country: United States
facility: Pinnacle Health Cardiovascular Institute
state: Pennsylvania
city: Lansdowne
country: United States
facility: George Isajiw, MD
state: Pennsylvania
city: Morrisville
country: United States
facility: Bucks County Clinical Research
state: Pennsylvania
city: Philadelphia
country: United States
facility: Drexel University College of Medicine
state: Pennsylvania
city: Philadelphia
country: United States
facility: Hospital of the University of Pennsylvania
state: Pennsylvania
city: Sellersville
country: United States
facility: Lehigh Valley Health Services
state: Pennsylvania
city: Uniontown
country: United States
facility: Pish Medical Associates, Inc.
state: Pennsylvania
city: Whitehall
country: United States
facility: Lehigh Valley Family Practice
state: Pennsylvania
city: Wilkes-Barre
country: United States
facility: Wilkes-Barre VA Medical Center
state: Pennsylvania
city: Cumberland
country: United States
facility: Partners in Clinical Research
state: Rhode Island
city: Lincoln
country: United States
facility: Ocean State Clinical Research Prtnr
state: Rhode Island
city: Pawtucket
country: United States
facility: Memorial Hospital of Rhode Island
state: Rhode Island
city: Providence
country: United States
facility: The Miriam Hospital
state: Rhode Island
city: Providence
country: United States
facility: Ocean State Research Institute, Inc
state: Rhode Island
city: Columbia
country: United States
facility: South Carolina Heart Center
state: South Carolina
city: Columbia
country: United States
facility: Amistad Research Center, LLC
state: South Carolina
city: Indian Land
country: United States
facility: Charlotte Hearts
state: South Carolina
city: Irmo
country: United States
facility: Miller - SC Internal Medicine Associates.: Irmo
state: South Carolina
city: Pawleys Island
country: United States
facility: Inlet Cardiopulmonary & Associates
state: South Carolina
city: Spartanburg
country: United States
facility: Fusion Clinical Research of Spartanburg
state: South Carolina
city: Spartanburg
country: United States
facility: Palmetto Research Center, LLC
state: South Carolina
city: Chattanooga
country: United States
facility: New Phase Research & Development
state: Tennessee
city: Fayetteville
country: United States
facility: Parkway Medical Group
state: Tennessee
city: Germantown
country: United States
facility: Stern Cardiovascular Foundation, Inc.
state: Tennessee
city: Jackson
country: United States
facility: Kore Cardiovascular Research Institutue
state: Tennessee
city: Knoxville
country: United States
facility: New Phase Research & Development
state: Tennessee
city: Knoxville
country: United States
facility: Cardiovascular Research of Knoxville
state: Tennessee
city: Memphis
country: United States
facility: Ramanathan - VAMC Memphis
state: Tennessee
city: Nashville
country: United States
facility: Clinical Research Center Meharry Medical College
state: Tennessee
city: Austin
country: United States
facility: Avant Research Associates LLC
state: Texas
city: Austin
country: United States
facility: Texas Heart and Vascular Research, LLC
state: Texas
city: Beaumont
country: United States
facility: Southeast TX Clinical Research Center
state: Texas
city: Big Spring
country: United States
facility: Cornerstone Family Medicine
state: Texas
city: Carrollton
country: United States
facility: IMD Medical Center
state: Texas
city: Carrollton
country: United States
facility: Texas Health Physicians Group
state: Texas
city: Dallas
country: United States
facility: Cardiovascular Research Institute of Dallas
state: Texas
city: Dallas
country: United States
facility: North Texas Health Center
state: Texas
city: Dallas
country: United States
facility: The Heart Center of Dallas
state: Texas
city: DeSoto
country: United States
facility: Global Medical Research
state: Texas
city: Fort Worth
country: United States
facility: The Medical Group of Texas
state: Texas
city: Fort Worth
country: United States
facility: Texas Health Physicians Group
state: Texas
city: Haltom City
country: United States
facility: T&R Clinic, P.A.
state: Texas
city: Houston
country: United States
facility: Michele P. Sartori, MD
state: Texas
city: Katy
country: United States
facility: Grand Medical Care
state: Texas
city: Killeen
country: United States
facility: Team Research Of Central Texas
state: Texas
city: Kingwood
country: United States
facility: Houston Heart and Vascular Associates
state: Texas
city: Marshall
country: United States
facility: Grace Research, LLC
state: Texas
city: McAllen
country: United States
facility: Valley Heart Consultants
state: Texas
city: Mineral Wells
country: United States
facility: Heart Center, Palo Pinto General Hospital
state: Texas
city: Mission
country: United States
facility: Valley Central Research Inc
state: Texas
city: North Richland Hills
country: United States
facility: North Hills Medical Research, Inc
state: Texas
city: Palestine
country: United States
facility: Grace Research, LLC
state: Texas
city: Port Arthur
country: United States
facility: Avant Research Associates, LLC
state: Texas
city: San Antonio
country: United States
facility: Santoscoy - Health Texas Research Institute
state: Texas
city: San Antonio
country: United States
facility: Element Research Group
state: Texas
city: San Antonio
country: United States
facility: Schnitzler Cardiovascular Consultants
state: Texas
city: San Antonio
country: United States
facility: San Antonio Endovascular & Heart Institute
state: Texas
city: Sugar Land
country: United States
facility: Acacia Medical Research Institute
state: Texas
city: Sugar Land
country: United States
facility: Health Plus Clinical Research
state: Texas
city: Tomball
country: United States
facility: Lone Star Heart and Vascular Center
state: Texas
city: Tomball
country: United States
facility: Northwest Houston Clinical Research
state: Texas
city: Waco
country: United States
facility: Hillcrest Family Health Center
state: Texas
city: Layton
country: United States
facility: Utah Cardiology, P.C.
state: Utah
city: Salt Lake City
country: United States
facility: Utah Diabetes Center
state: Utah
city: White River Junction
country: United States
facility: VA Medical Center, White River Junction
state: Vermont
city: Burke
country: United States
facility: Burke Internal Medicine & Research
state: Virginia
city: Falls Church
country: United States
facility: Seven Corners Medical Research Center
state: Virginia
city: Hampton
country: United States
facility: Hampton Family Practice Research
state: Virginia
city: Hampton
country: United States
facility: Tidewater Physicians Multispecialty Group
state: Virginia
city: Manassas
country: United States
facility: Virginia Cardiovascular Associates
state: Virginia
city: Manassas
country: United States
facility: Manassas Clinical Research Center
state: Virginia
city: Mechanicsville
country: United States
facility: Tucker Cardiology Associates, P.C.
state: Virginia
city: Newport News
country: United States
facility: TPMG Clinical Research
state: Virginia
city: Norfolk
country: United States
facility: Sentara Norfolk General Hospital
state: Virginia
city: Roanoke
country: United States
facility: Roanoke Heart Institute PLC
state: Virginia
city: Woodbridge
country: United States
facility: Cardinal Internal Medicine Associates
state: Virginia
city: Yorktown
country: United States
facility: Tidewater Physicians Multispecialty Group
state: Virginia
city: Port Orchard
country: United States
facility: Frandsen Family Medicine DBA Sound Medi
state: Washington
city: Spokane
country: United States
facility: Premier Clinical Research
state: Washington
city: Spokane
country: United States
facility: Kootenai Heart Clinics, LLC
state: Washington
city: Spokane
country: United States
facility: Northside Internal Medicine
state: Washington
city: Vancouver
country: United States
facility: Northwest Medical Associates, P.S.
state: Washington
city: Green Bay
country: United States
facility: Cardiology Associates of Bellin Health
state: Wisconsin
city: Madison
country: United States
facility: Dean Foundation
state: Wisconsin
city: Madison
country: United States
facility: University Of Wisconsin
state: Wisconsin
city: Marshfield
country: United States
facility: Marshfield Clinic
state: Wisconsin
city: Milwaukee
country: United States
facility: Columbia St. Mary's
state: Wisconsin
city: Milwaukee
country: United States
facility: Aurora St. Luke's Medical Center
state: Wisconsin
city: North Vancouver
country: Canada
facility: The Medical Arts Health Research Group
state: British Columbia
city: Penticton
country: Canada
facility: The Medical Arts Health Research Group
state: British Columbia
city: Winnipeg
country: Canada
facility: Winnipeg Clinic
state: Manitoba
city: Brampton
country: Canada
facility: Bramalea Medical Centre
state: Ontario
city: Brampton
country: Canada
facility: Brampton Research Associates
state: Ontario
city: Burlington
country: Canada
facility: Philippe R Beaudry Medicine Professional Corporation
state: Ontario
city: Cambridge
country: Canada
facility: Vizel Cardiac Research
state: Ontario
city: Chatham
country: Canada
facility: Dr. Linda Sinnaeve's Office
state: Ontario
city: Cornwall
country: Canada
facility: Scisco Clinical Research
state: Ontario
city: Guelph
country: Canada
facility: Dr. Peter Spadafora Health Center
state: Ontario
city: Hamilton
country: Canada
facility: John Stimac, MD
state: Ontario
city: Hamilton
country: Canada
facility: KMH Cardiology & Diagnostics: Hamilton
state: Ontario
city: Hamilton
country: Canada
facility: Dr. William Liang
state: Ontario
city: Hawkesbury
country: Canada
facility: Source Unique Clinic
state: Ontario
city: Kitchener
country: Canada
facility: Dr. Ronald Fowlis
state: Ontario
city: London
country: Canada
facility: University Hospital
state: Ontario
city: Mississauga
country: Canada
facility: Malton Medical Research
state: Ontario
city: Mississauga
country: Canada
facility: KMH Cardiology & Diagnostics: Mississauga
state: Ontario
city: Mississauga
country: Canada
facility: Sewa Ram Singal Medicine Professional Corporation
state: Ontario
city: Newmarket
country: Canada
facility: Newmarket Cardiology Research Group
state: Ontario
city: Newmarket
country: Canada
facility: Newmarket Cardiology Research Group
state: Ontario
city: Niagara Falls
country: Canada
facility: Portage Medical Centre
state: Ontario
city: North York
country: Canada
facility: Humber River Regional Hospital
state: Ontario
city: Oshawa
country: Canada
facility: Bakbak Medicine Professional Corporation
state: Ontario
city: Oshawa
country: Canada
facility: Dr. James Y. Cha
state: Ontario
city: Ottawa
country: Canada
facility: University Of Ottawa Heart Institute
state: Ontario
city: Peterborough
country: Canada
facility: Kawartha Cardiology Clinical Trials
state: Ontario
city: Pickering
country: Canada
facility: Steeple Hill Medical Centre
state: Ontario
city: Sarnia
country: Canada
facility: Sarnia Institute Of Clinical Research
state: Ontario
city: Scarborough
country: Canada
facility: Scarborough Cardiology Research
state: Ontario
city: Scarborough
country: Canada
facility: Scarborough General Hospital Cardiology Research Associates
state: Ontario
city: Scarborough
country: Canada
facility: Milliken Medical Centre
state: Ontario
city: Smith Falls
country: Canada
facility: Canadian Centre for Research on Diabetes
state: Ontario
city: St. Catharines
country: Canada
facility: Lake Shore Cardiology
state: Ontario
city: St. Thomas
country: Canada
facility: Sardar Medical Clinic
state: Ontario
city: Sudbury
country: Canada
facility: G.S. Cardiac Lab Medicine Professional Corp
state: Ontario
city: Sudbury
country: Canada
facility: Dr. R. Labonte Professional Med Corp
state: Ontario
city: Sudbury
country: Canada
facility: Dr. G. Garrioch, Independent Practice
state: Ontario
city: Thedford
country: Canada
facility: Dr. Laurence Gibbs Medicine Professional Corp.
state: Ontario
city: Tillsonburg
country: Canada
facility: Tillsonburg Medical Centre
state: Ontario
city: Toronto
country: Canada
facility: Humber River Hospital
state: Ontario
city: Toronto
country: Canada
facility: Sunnybrook Health Sciences Centre
state: Ontario
city: Toronto
country: Canada
facility: St. Michael's Hospital
state: Ontario
city: Toronto
country: Canada
facility: Mount Sinai Hospital
state: Ontario
city: Toronto
country: Canada
facility: Toronto General Hospital
state: Ontario
city: Toronto
country: Canada
facility: Weston Road Medical Clinic
state: Ontario
city: Whitby
country: Canada
facility: Dr. Nigel Jagan Medicine Professional Corporation
state: Ontario
city: Windsor
country: Canada
facility: Dr. Nwadiaro Medicine Professional Corp
state: Ontario
city: Brossard
country: Canada
facility: Viacar Recherche Clinique Inc.
state: Quebec
city: Chicoutimi
country: Canada
facility: Ecogene-21
state: Quebec
city: Chicoutimi
country: Canada
facility: Q&T Research Chicoutimi
state: Quebec
city: Greenfield Park
country: Canada
facility: Viacar Recherche Clinique Inc.
state: Quebec
city: Montreal
country: Canada
facility: CHUM Hotel-Dieu
state: Quebec
city: Quebec City
country: Canada
facility: Iucpq
state: Quebec
city: Québec
country: Canada
facility: ALPHA Recherche Clinique
state: Quebec
city: Saint-Jean-sur-Richelieu
country: Canada
facility: CardioVasc HR
state: Quebec
city: Saint-Lambert
country: Canada
facility: ViaCar Recherche Clinique Inc
state: Quebec
city: St. Lambert
country: Canada
facility: Viacar Recherche Clinique
state: Quebec
city: Terrebonne
country: Canada
facility: Hopital Pierre-Le Gardeur
state: Quebec
city: Quebec
country: Canada
facility: Recherche Clinique Sigma, Inc.
city: Bayamón
country: Puerto Rico
facility: Instituto Sanacoop
city: Caguas
country: Puerto Rico
facility: San Juan Bautista School of Medicine
city: Canovanas
country: Puerto Rico
facility: Norma S. Severino-Pacheco, MD
city: Ponce
country: Puerto Rico
facility: Cardiometabolic Research Center
city: San Juan
country: Puerto Rico
facility: Miguel Sosa-Padilla, MD
city: Toa Baja
country: Puerto Rico
facility: Yolanda Sierra Quinones, MD
Study officials:
affiliation: Brigham and Women's Hospital
name: Paul Ridker, MD, MPH
role: PRINCIPAL_INVESTIGATOR
References:
citation: Cui J, Chasman DI, Raychaudhuri S, Xu C, Ridker PM, Solomon DH, Karlson EW. Genetics are not likely to offer clinically useful predictions for elevated liver enzyme levels in patients using low dose methotrexate. Semin Arthritis Rheum. 2022 Aug;55:152036. doi: 10.1016/j.semarthrit.2022.152036. Epub 2022 May 28.
citation: Reiss AB, Teboul I, Kasselman L, Ahmed S, Carsons SE, De Leon J. Methotrexate effects on adenosine receptor expression in peripheral monocytes of persons with type 2 diabetes and cardiovascular disease. J Investig Med. 2022 Aug;70(6):1433-1437. doi: 10.1136/jim-2022-002355. Epub 2022 May 23.
citation: Xu C, Selhub J, Jacques P, Paynter NP, MacFadyen JG, Glynn RJ, Ridker PM, Solomon DH. Adverse effects related to methotrexate polyglutamate levels: adjudicated results from the cardiovascular inflammation reduction trial. Rheumatology (Oxford). 2021 Jun 18;60(6):2963-2968. doi: 10.1093/rheumatology/keaa650.
citation: Sparks JA, Dellaripa PF, Glynn RJ, Paynter NP, Xu C, Ridker PM, Solomon DH. Pulmonary Adverse Events in Patients Receiving Low-Dose Methotrexate in the Randomized, Double-Blind, Placebo-Controlled Cardiovascular Inflammation Reduction Trial. Arthritis Rheumatol. 2020 Dec;72(12):2065-2071. doi: 10.1002/art.41452. Epub 2020 Oct 7.
citation: Ridker PM, MacFadyen JG, Glynn RJ, Bradwin G, Hasan AA, Rifai N. Comparison of interleukin-6, C-reactive protein, and low-density lipoprotein cholesterol as biomarkers of residual risk in contemporary practice: secondary analyses from the Cardiovascular Inflammation Reduction Trial. Eur Heart J. 2020 Aug 14;41(31):2952-2961. doi: 10.1093/eurheartj/ehaa160.
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