Clinical trial NCT03921528: An Active Treatment Study of SRK-015 in Patients With Type 2 or Type 3 Spinal Muscular Atrophy
Official title: Phase 2 Active Treatment Study to Evaluate the Efficacy and Safety of SRK-015 in Patients With Later-Onset Spinal Muscular Atrophy (TOPAZ)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Spinal Muscular Atrophy
Spinal Muscular Atrophy Type 3
Spinal Muscular Atrophy Type 2
SMA
Neuromuscular Diseases
Muscular Atrophy
Atrophy
Muscular Atrophy, Spinal
Neuromuscular Manifestations
Lead sponsor: Scholar Rock, Inc.
Sponsor class: INDUSTRY
First posted: 2019-04-19
Enrollment: 58
Sex: ALL
Minimum age (years): 2
Maximum age (years): 21
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The TOPAZ study will assess the safety and efficacy of SRK-015 in later-onset Spinal Muscular Atrophy (SMA Type 2 and Type 3) in pediatric and adult patients.


Eligibility criteria: Inclusion Criteria:

* Age 5 through 21 years old at the time of screening for Cohorts 1 and 2; Age ≥2 years old at the time of screening for Cohort 3.
* Documented diagnosis of 5q SMA.
* Diagnosed as later-onset (e.g., Type 2 or Type 3) SMA prior to receiving any treatment with therapy approved for SMA.
* Non-ambulatory patients must be able to sit independently (sits up straight with head erect for at least 10 seconds; does not use arms or hands to balance body or support position) per World Health Organization (WHO) motor milestones definition at screening.
* Ambulatory patients must have the ability to independently ambulate without aids or orthotics over 10 meters in 30 seconds or less at screening.
* Receiving the same background SMA therapy (e.g., on an approved survival motor neuron (SMN) upregulator therapy such as nusinersen, or not on any SMA therapy) for at least 6 months prior to screening and anticipated to remain on that therapy throughout the duration of the study.

  * If receiving the SMN upregulator therapy nusinersen, must have completed the loading regimen and initiated maintenance dosing (i.e., completed at least one maintenance dose) with at least 4 weeks after the first maintenance dose having elapsed prior to screening.
* Nutritional status stable over the past 6 months and anticipated to be stable throughout the duration of the study.
* Have no physical limitations that would prevent the patient from undergoing motor function outcome measures throughout the duration of the study.
* Able to receive study drug infusions and provide blood samples through the use of a peripheral intravenous (IV) or a long-term IV access device that the patient has placed for reasons independent from the study throughout the duration of the study.
* Able to adhere to the requirements of the protocol, including travel to the study center and completing all study procedures and study visits.
* For patients who are expected to have reached reproductive maturity by the end of the study, adhere to study specific contraception requirements.

Exclusion Criteria:

* Use of tracheostomy with positive pressure.
* Use of chronic daytime non-invasive ventilatory support for \>16 hours daily in the 2 weeks prior to dosing, or anticipated to regularly receive such daytime ventilator support chronically over the duration of the study.
* Any acute or co-morbid condition interfering with the well-being of the patient within 14 days of screening, including active systemic infection, the need for acute treatment or inpatient observation due to any reason.
* Severe scoliosis and/or contractures at screening. Based on clinical judgement, any scoliosis or contractures present must be stable over the past 6 months, anticipated to be stable for the duration of the study and not prevent the patient from being evaluated on any functional outcome measures throughout the duration of the study.
* Pregnant or breastfeeding.
* Major orthopedic or other interventional procedure, including spine or hip surgery, considered to have the potential to substantially limit the ability of the patient to be evaluated on any functional outcome measures, within 6 months prior to screening, or anticipated for the duration of the study.
* Prior history of a hypersensitivity reaction to a monoclonal antibody (mAb) or recombinant protein bearing an Fc domain (such as a soluble receptor- Fc fusion protein).
* Use of systemic corticosteroids within 60 days prior to screening. Inhaled or topical steroids are allowed.
* Treatment with investigational drugs within 3 months prior to screening.
* Use of therapies with potentially significant muscle effects (such as androgens, insulin-like growth factor, growth hormone, systemic betaagonist, botulinum toxin, or muscle relaxants) or muscle-enhancing supplements within 60 days prior to screening.
* Patient has any other condition, which in the opinion of the Investigator may compromise safety or compliance, would preclude the patient from successful completion of the study, or interfere with the interpretation of the results.

Primary outcomes:
measure: Cohort 1: Change From Baseline in the Revised Hammersmith Scale (RHS) Total Score at Day 364 (Visit 15) [Month 12]
timeFrame: Baseline up to 12 months
measure: Cohort 2 and Cohort 3: Change From Baseline in Hammersmith Functional Motor Scale Expanded (HFMSE) Total Score at Day 364 (Visit 15) [Month 12]
timeFrame: Baseline up to 12 months
Secondary outcomes:
measure: Cohort 1:Change From Baseline in the Revised Hammersmith Scale (RHS) Total Score at Other Prespecified Timepoints
timeFrame: Baseline to 12 months
measure: Cohort 1: Proportion of Patients Achieving Various Magnitudes of Change in RHS Score From Baseline
timeFrame: Baseline to 12 months
measure: Cohort 1: Change From Baseline in 6-Minute Walk Test (6MWT)
timeFrame: Baseline to 12 months
measure: Cohort 1: Change From Baseline in 30-Second Sit-to-Stand
timeFrame: Baseline to 12 months
measure: Cohort 1: Change From Baseline in 10-Meter Walk/Run (From RHS)
timeFrame: Baseline to 12 months
measure: Cohort 1: Change From Baseline in Timed Rise From Floor (From RHS)
timeFrame: Baseline to 12 months
measure: Cohort 2 &3: Change From Baseline in HFMSE Total Score at Other Prespecified Timepoints
timeFrame: Baseline to 12 months
measure: Cohort 2 & 3: Proportion of Patients Achieving Various Magnitudes of Change in HFMSE Score From Baseline
timeFrame: Baseline to 12 months
measure: Cohort 2 & 3: Change in Baseline in Revised Upper Limb Module (RULM) Total Score
timeFrame: Baseline to 12 months
measure: Cohort 2 & 3: Proportion of Patients Achieving a New WHO Motor Development Milestones Relative to Baseline
timeFrame: Baseline to 12 months
measure: Cohort 2 & 3: Proportion of Patients Achieving Various Magnitudes of Change in RULM Score From Baseline
timeFrame: Baseline to 12 months
Other outcomes:
Locations:
city: Phoenix
country: United States
facility: Phoenix Children's Hospital
state: Arizona
city: Palo Alto
country: United States
facility: Stanford University
state: California
city: Aurora
country: United States
facility: Children's Hospital Colorado
state: Colorado
city: Baltimore
country: United States
facility: The Johns Hopkins University
state: Maryland
city: Boston
country: United States
facility: Boston Children's Hospital
state: Massachusetts
city: Grand Rapids
country: United States
facility: Helen DeVos Children's Hospital
state: Michigan
city: New York
country: United States
facility: Columbia University
state: New York
city: Winston-Salem
country: United States
facility: Wake Forest School of Medicine
state: North Carolina
city: Portland
country: United States
facility: Oregon Health & Science University
state: Oregon
city: Dallas
country: United States
facility: Childrens Medical Center Dallas
state: Texas
city: Norfolk
country: United States
facility: Children's Hospital of The King's Daughters
state: Virginia
city: Milano
country: Italy
facility: ASST Grande Ospedale Metropolitano Niguarda
city: Roma
country: Italy
facility: Centro Clinico Nemo Pediatrico Policlinico A. Gemelli-Università Cattolica Sacro Cuore
city: Utrecht
country: Netherlands
facility: Universitair Medisch Centrum Utrecht
city: Barcelona
country: Spain
facility: Hospital Sant Joan de Déu
city: Valencia
country: Spain
facility: Hospital Universitari i Politecnic La Fe
Study officials:
affiliation: Johns Hopkins University
name: Thomas O. Crawford, MD
role: PRINCIPAL_INVESTIGATOR
References: