Clinical trial NCT05381493: Incidence and Outcomes of Acute Kidney Injury in Trauma Patients Admitted to Critical Care
Official title: Incidence and Outcomes of Acute Kidney Injury in Trauma Patients Admitted to Critical Care
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Acute Kidney Injury
Trauma; Complications
Keywords: Trauma
Acute Kidney Injury
Intensive Care Unit
Lead sponsor: Ankara University
Sponsor class: OTHER
Collaborators: name: Bengi Şafak
name: Keziban Sanem Çakar Turhan
name: Mustafa Onur Karaca
name: Uğur Aydoğan
name: Ali Abbas Yılmaz
name: Mustafa Kemal Bayar
First posted: 2022-05-19
Enrollment: 171
Sex: ALL
Minimum age (years): 18
Maximum age (years): 97
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: all type of trauma patients admitted to level 3 ICU

Brief summary: Acute kidney injury (AKI) is a common complication that increases lenght of stay and mortality in trauma patients admitted to the intensive care unit (ICU). The aim of this study is to identify the incidence and outcomes of trauma patients, defined by Kidney Disease Improving Global Outcomes (KDIGO) criteria, at single center level 3 ICU.

Detailed description: Trauma can cause high mortality and morbidity by affecting different organ systems. Acute kidney injury (AKI) is a common complication in trauma patients admitted to the intensive care unit (ICU). Direct kidney injury, hypotension, hypoperfusion, rhabdomyolysis, abdominal compartment syndrome, sepsis and critical care medications are possible causes of AKI in trauma patients. The incidence of AKI can be up to 10%, and mortality rate up to 60-80% in trauma patients. Since AKI is not only a rare complication but also a risk factor for mortality in critically ill trauma patients, it is essential to establish a strategy to prevent AKI and related complications, to determine the incidence and risk factors of AKI, and to improve patients outcomes. Survivors of AKI may have variable recovery of kidney function and might prone to late morbidity and mortality. In this study incidence of AKI was defined using the KDIGO criteria according to the change of serum creatine levels.

171 all type of trauma patients admitted to level 3 ICU, from January 2014 to December 2018 included the retrospectve observational study. Demographic data, type of injury, rates of complications, risk factors for AKI, mortality, lenght of stay (LOS) in ICU were evaluated. Acute Physiology and Chronic Health Evaluation (APACHE II and IV) score, Simplified Acute Physiology Score (SAPS II and III), Glasgow Coma Scale (GCS), Injury Severity Score (ISS) and, Trauma Injury Severity Score (TRISS) were calculated on the day of admission. AKI was defined using the KDIGO criteria according to the serum creatinine. The SPSS 11.5 program was used for statistical analysis.

Eligibility criteria: Inclusion Criteria:

* all type of trauma patients admitted to level 3 ICU, from January 2014 to December 2018

Exclusion Criteria:

-

Primary outcomes:
measure: Acute kidney injury in trauma patients
timeFrame: one week
Secondary outcomes:
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Süheyla Karadağ Erkoç
Study officials:
affiliation: Ankara University
name: Süheyla Karadağ Erkoç
role: PRINCIPAL_INVESTIGATOR
References: