Clinical trial NCT03342651: Preoperative Vitamin D Levels and Respiratory Complications of General Anesthesia
Official title: Evaluation of the Effect of Preoperative Vitamin D Levels and Respiratory Complications of General Anesthesia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Vitamin D Deficiency
Keywords: Vitamin D
general anesthesia
respiratory complications
Lead sponsor: T.C. ORDU ÜNİVERSİTESİ
Sponsor class: OTHER
First posted: 2017-11-17
Enrollment: 95
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Vitamin D deficiency is a commonly observed health problem in the world. With a role in many chronic diseases and especially lung diseases, the importance of vitamin D deficiency in anesthesia management is increased. This research aims to investigate whether there is a correlation between the respiratory complications occurring in patients under general anesthesia and preoperative vitamin D levels.

Detailed description: This study included 95 adult cases aged from 18-65 years operated under general anesthesia. The cases had total 25-hydroxyvitamin D (25OHD) levels identified in blood samples before the operation. Patients given routine general anesthesia and postoperative monitoring procedures were assessed in terms of respiratory complications during anesthesia induction, extubation, anesthesia recovery and the first 24 hours postoperative.

This research observed that patients with low preoperative 25OHD vitamin levels encountered respiratory complications related to general anesthesia more often. Especially in the early postoperative period there is a very significant difference between complications and low 25OHD vitamin levels. Our study results show that low vitamin D levels may be a potential risk in terms of respiratory complications related to general anesthesia causing severe morbidity and mortality increase. The results lead to the consideration that optimizing vitamin D levels in the preoperative period for patients undergoing general anesthesia may aid in reducing complications.

Eligibility criteria: Inclusion Criteria:

- American Society of Anesthesiologists I - II risk classification, healthy adult surgery cases

Exclusion Criteria:

* Thoracic surgery, those with severe respiratory, neuromuscular or endocrine system diseases, those with difficult intubation, morbid obesity, using vitamin D supplements and those who smoked

Primary outcomes:
measure: Relationship between Vitamin D levels and respiratory complications
timeFrame: Perioperative period
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Ordu University, Turkey
name: Nilay Taş, Assoc.Prof.
role: PRINCIPAL_INVESTIGATOR
affiliation: Ordu University, Turkey
name: Tevfik Noyan, Prof.
role: STUDY_CHAIR
affiliation: Ordu University, Turkey
name: Özgür Yağan, Assoc. Prof.
role: STUDY_CHAIR
affiliation: Ordu University, Turkey
name: Volkan Hancı, Prof.
role: STUDY_CHAIR
affiliation: Ordu University, Turkey
name: Ebru Çanakçı, Ass. Prof.
role: STUDY_CHAIR
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