Clinical trial NCT04508270: Significance of Early Mobilization After VATS-L
Official title: Physiological Evidence for Early Mobilization in Thoracoscopic Lobectomy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Lung Neoplasm
Physiology
Exercise
Lung Function
Arterial Oxygen Saturation
Keywords: Postoperative mobilization
Physiology
Thoracoscopy
Lobectomy
Lead sponsor: Rigshospitalet, Denmark
Sponsor class: OTHER
First posted: 2020-08-11
Enrollment: 24
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients scheduled for VATS-L.

Brief summary: The main endpoint is physiological rehabilitation after VATS-L under early mobilization. The secondary endpoints are exploring the effect of early mobilization on postoperative physiology.

Investigators hypothesis that early mobilization is clearly advantaged to advance the physiological recovery.


Eligibility criteria: Inclusion Criteria:

1. VATS lobectomy;
2. Speak and understand Danish or English;
3. Informed consent obtained.

Exclusion Criteria:

1. Co-VATS lobectomy (more than one lobe resection);
2. Supplementary oxygen therapy later 6 h after surgery;
3. No willing to wear electronic device;
4. No willing to exam arterial oxygen saturation.

Primary outcomes:
measure: Postoperative forced expiratory volume in one second (FEV1)
timeFrame: Through study completion, an average of 3 days
measure: Postoperative arterial oxygen saturation.
timeFrame: Through study completion, an average of 3 days
Secondary outcomes:
measure: The quantization of activity counts
timeFrame: Through study completion, an average of 3 days
measure: The quantization of pain
timeFrame: Through study completion, an average of 3 days
measure: length of stay in hospital
timeFrame: Through study completion, an average of 3 days
measure: Duration of chest tube
timeFrame: Through study completion, an average of 2 days
measure: Postoperative complications
timeFrame: up to 30 days
Other outcomes:
Locations:
city: Copenhagen
country: Denmark
facility: Rigshospitalet
Study officials:
affiliation: Rigshospitalet, Denmark
name: Lin Huang, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Rigshospitalet, Denmark
name: Henrik Kehlet, Professor, MD, DMSc
role: STUDY_DIRECTOR
affiliation: Rigshospitalet, Denmark
name: Rene H Petersen, Professor, MD, PhD
role: STUDY_CHAIR
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citation: Kirkeby-Garstad I, Wisloff U, Skogvoll E, Stolen T, Tjonna AE, Stenseth R, Sellevold OF. The marked reduction in mixed venous oxygen saturation during early mobilization after cardiac surgery: the effect of posture or exercise? Anesth Analg. 2006 Jun;102(6):1609-16. doi: 10.1213/01.ANE.0000219589.03633.BF.
citation: Huang L, Kehlet H, Petersen RH. Effect of posture on pulmonary function and oxygenation after fast-tracking video-assisted thoracoscopic surgery (VATS) lobectomy: a prospective pilot study. Perioper Med (Lond). 2021 Sep 2;10(1):26. doi: 10.1186/s13741-021-00199-z.