Clinical trial NCT03879993: Resistance Training in People Living With HIV/AIDS
Official title: Effects of Resistance Training in People Living With HIV/AIDS
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: HIV/AIDS
Keywords: Exercise
Cognition
Body composition
Inflammatory biomarkers
CD4
Lead sponsor: State University of Maringá
Sponsor class: OTHER
First posted: 2019-03-19
Enrollment: 49
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this study will be to verify effects of resistance training in people living with HIV/AIDS.

Detailed description: The aim of this study was verify effects of resistance training in cognitive function, body composition and biochemical parameters of inflammation and oxidative stress in people living with HIV/AIDS. The sample was composed by patients with HIV/AIDS of both sexes. The patients were randomized in two groups, a exercise group (EG), which was receive intervention with eight weeks of resistance training, and a control group (CG), that was not to do exercise. The cognitive function was analyzed with Stroop Test and Trail Test; body composition was evaluated by bioimpedance; blood tests was use to analyze biochemical parameters of inflammation and oxidative stress. For statistical analysis was used ANOVA of two factors for repeated measurements, having the (EG and PG) group and the time (pre and post exercise). Level of significance adopted was P \< 0,05.

Eligibility criteria: Inclusion Criteria:

* Clinical diagnostic for HIV/AIDS.
* Clinical condition and viral count stabilized.
* Have been using (HAART) for 6 months or more.
* Not have participated in physical exercise programs in six months before beginning of study.
* Not have muscle or joint injuries that make it impossible to practice physical activity.
* Not be pregnant.

Exclusion Criteria:

* Not attending more than 15% of the intervention sessions or visits to the laboratory.
* Aggravation of the disease.
* Stick to a physical activity program in addition to that offered by the study.

Primary outcomes:
measure: Change in Cognitive Function
timeFrame: Baseline and eight weeks
Secondary outcomes:
measure: CD4 / CD8
timeFrame: Baseline and eight weeks
measure: Concentration of Inflammatory markers
timeFrame: Baseline and eight weeks
measure: Health cellular
timeFrame: Baseline and eight weeks
Other outcomes:
measure: Change in body composition
timeFrame: Baseline and eight weeks
measure: Change in body circumferences
timeFrame: Baseline and eight weeks
measure: Change brachial blood pressure
timeFrame: Baseline and eight weeks
measure: Change autonomic cardiac modulation
timeFrame: Baseline and eight weeks
measure: Change in handgrip strength
timeFrame: Baseline and eight weeks
measure: Change in flexibility
timeFrame: Baseline and eight weeks
measure: Training load control
timeFrame: Baseline and eight weeks
Locations:
city: Maringá
country: Brazil
facility: State University of Maringá
state: PR
Study officials:
affiliation: State University of Maringá
name: Ademar Avelar, PhD
role: PRINCIPAL_INVESTIGATOR
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