Clinical trial NCT06935370: A Study to Test Whether Vicadrostat (BI 690517) in Combination With Empagliflozin Helps People With Heart Failure and a Weak Pumping Function of the Left Side of the Heart
Official title: EASi-HF Reduced - A Phase III Double-blind, Randomised, Parallel-group Superiority Trial to Evaluate Efficacy and Safety of the Combined Use of Oral Vicadrostat (BI 690517) and Empagliflozin Compared With Placebo and Empagliflozin in Participants With Symptomatic Chronic Heart Failure (HF: NYHA II-IV) and Left Ventricular Ejection Fraction (LVEF) < 40%
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE3
Conditions: Heart Failure
Lead sponsor: Boehringer Ingelheim
Sponsor class: INDUSTRY
First posted: 2025-04-20
Enrollment: 4200
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study is open to adults with chronic heart failure (HF) who have a reduced left ventricular ejection fraction (LVEF) of less than 40%. People can join the study if they have been diagnosed with chronic HF at least 3 months before the study. The purpose of this study is to find out whether a medicine called vicadrostat, in combination with another medicine called empagliflozin, helps people with chronic heart failure.

In this study, participants are put into 2 groups randomly. Participants have an equal chance of being in either group. One group takes vicadrostat and empagliflozin tablets, and the other group takes placebo and empagliflozin tablets. Placebo tablets look like vicadrostat tablets but do not contain any medicine. Participants take the study medicines as tablets once a day for between 1 and about 3.5 years. During this time, they can continue their regular treatment for heart failure.

Participants can stay in the study as long as they benefit from treatment and can tolerate it, for a maximum of about 3.5 years. During this time, they visit the study site regularly. The exact number of visits is different for each participant, depending on how long they stay in the study. The study staff may also contact the participants by phone. Participants also regularly answer questions about their well-being. The doctors document when participants experience worsening of their heart failure symptoms, must go to hospital due to heart failure, or die during the study. The time until these events are observed is compared between the treatment groups to see whether the treatment works. The doctors also regularly check participants' health and take note of any unwanted effects.


Eligibility criteria: Inclusion criteria:

1. At least 18 years old and at least at the legal age of consent in countries where it is greater than 18 years
2. Signed and dated written informed consent in accordance with International Council for Harmonisation of Technical Requirements for Pharmaceuticals for Human Use - Good Clinical Practice (ICH-GCP) and local legislation prior to admission to the trial
3. Male or female participants. Women of childbearing potential (WOCBP) must be ready and able to use highly effective methods of birth control per ICH M3 (R2) that result in a low failure rate of less than 1% per year when used consistently and correctly. A list of contraception methods meeting these criteria and instructions on the duration of their use is provided in the protocol.
4. Chronic heart failure (HF) diagnosed at least 3 months before Visit 1, and in New York Heart Association (NYHA) classes II to IV at Visit 1, with left ventricular ejection fraction (LVEF) \< 40% per local reading (obtained by echocardiography, radionuclide ventriculography, invasive angiography, magnetic resonance imaging (MRI), or computed tomography (CT)).
5. Elevated N-terminal pro-brain natriuretic peptide (NT-proBNP) at Visit 1, analysed at the central laboratory
6. Treated according to best possible standard of care (SOC) (disregarding sodium-dependent glucose co-transporter 2 inhibitor (SGLT2i) and mineralocorticoid receptor antagonist (MRA)) in accordance with applicable heart failure (HF) local/international guidelines and judgement of the investigator.

Additional inclusion criteria apply.

Exclusion criteria:

1. Treatment with an MRA (e.g. spironolactone, eplerenone, finerenone) within 14 days prior to Visit 1 or requiring such treatment before randomisation or planned during the trial based on the judgment of the investigator. Treatment with an MRA should not be discontinued with the intention of study enrolment.
2. Treatment with amiloride or other potassium-sparing diuretic within 14 days prior to Visit 1 or requiring such treatment before randomisation or planned during the trial based on the judgment of the investigator.
3. Receiving the following treatments:

   * A direct renin inhibitor (e.g. aliskiren) at Visit 2
   * More than one angiotensin-converting enzyme inhibitor (ACEi), angiotensin receptor blocker (ARB) or angiotensin receptor-neprilysin inhibitor (ARNi) used simultaneously at Visit 2
   * Other aldosterone synthase inhibitors, e.g. baxdrostat at Visit 2 or planned during the trial
   * Systemic mineralocorticoid replacement therapy (e.g. fludrocortisone) at Visit 2
   * In case of acute decompensated HF:

     * i.v. inotrope, i.v. vasodilating drug (e.g. nitrate, nitroprusside), or i.v. natriuretic peptide (e.g. nesiritide, carperitide), or mechanical support (e.g. intra-aortic balloon pump, endotracheal intubation, mechanical ventilation, any ventricular assist device) within 24 hours prior to randomisation
     * i.v. diuretic with a dose that has been increased/intensified within 6 hours prior to randomisation (a stable dose of an i.v. diuretic is not exclusionary)
4. Myocardial infarction (MI), transient ischemic attack (TIA), stroke, coronary artery bypass graft surgery (CABG), heart valve surgery/intervention or any other major surgery (major according to the investigator's assessment) within 90 days prior to Visit 2, or scheduled for major elective surgery (e.g. hip replacement, CABG)
5. Percutaneous coronary intervention (PCI) or any angiography using iodinated contrast agents in the 7 days prior to Visit 2
6. Heart transplant recipient, awaiting heart transplant, or currently implanted left ventricular assist device (LVAD)
7. Known cardiomyopathy based on infiltrative diseases (e.g. amyloidosis), accumulation diseases (e.g. haemochromatosis, Fabry disease), muscular dystrophies, hypertrophic obstructive cardiomyopathy or known pericardial constriction, or cardiomyopathy with potentially reversible cause such as stress or peripartum cardiomyopathy or cardiomyopathy induced by chemotherapy within 12 months prior to Visit 1 and until Visit 2
8. Acute inflammatory heart disease, such as acute myocarditis, within 90 days preceding prior to Visit 1 and until Visit 2 Further exclusion criteria apply.

Primary outcomes:
measure: Time to first event of Cardiovascular (CV) death, or Hospitalisation for heart failure (HHF), or Urgent heart failure (HF) visit
timeFrame: up to 43 months
Secondary outcomes:
measure: Key secondary endpoint: Time to first event of cardiovascular death or hospitalisation for heart failure
timeFrame: up to 43 months
measure: Key secondary endpoint: Occurrences of hospitalisation for heart failure (first and recurrent)
timeFrame: up to 43 months
measure: Key secondary endpoint: Absolute change from baseline in Kansas City Cardiomyopathy Questionnaire-Total Symptom Score (KCCQ-TSS) at Week 32
timeFrame: at baseline, at week 32
measure: Key secondary endpoint: Time to cardiovascular death
timeFrame: up to 43 months
measure: Key secondary endpoint: Time to all-cause mortality
timeFrame: up to 43 months
measure: Time to first hospitalisation for heart failure
timeFrame: up to 43 months
measure: Time to first occurrence of death from kidney failure, chronic dialysis* or renal transplant or onset of sustained reduction of ≥ 50% estimated glomerular filtration rate (eGFR) or onset of sustained eGFR (CKD-EPI)cr < 10 mL/min/1.73 m²
timeFrame: from baseline, up to 43 months
measure: Absolute change from baseline in Kansas City Cardiomyopathy Questionnaire- Clinical Summary Score (KCCQ-CSS) at Week 32
timeFrame: at baseline, at week 32
measure: Absolute change from baseline in Kansas City Cardiomyopathy Questionnaire-Total Symptom Score (KCCQ-TSS) at Week 52
timeFrame: at baseline, at week 52
measure: Absolute change from baseline in Kansas City Cardiomyopathy Questionnaire- Overall Summary Score (KCCQ-OSS) at Week 32
timeFrame: at baseline, at week 32
measure: Absolute change from baseline in KCCQ-OSS at Week 52
timeFrame: at baseline, at week 52
measure: Absolute change from baseline in systolic blood pressure (SBP) [mmHg] at Week 32 in participants with baseline SBP ≥ 130 mmHg
timeFrame: at baseline, at week 32
measure: Absolute change from baseline in diastolic blood pressure (DBP) [mmHg] at Week 32 in participants with baseline DBP ≥ 80 mmHg
timeFrame: at baseline, at week 32
Other outcomes:
Locations:
city: Mobile
country: United States
facility: Alliance for Multispecialty Research, LLC
state: Alabama
city: Montgomery
country: United States
facility: Drug Research and Analysis Corporation
state: Alabama
city: Covina
country: United States
facility: Valley Clinical Trials, Inc.
state: California
city: Lake Forest
country: United States
facility: Orange County Research Center
state: California
city: Northridge
country: United States
facility: Amicis Research Center
state: California
city: Thousand Oaks
country: United States
facility: Care Access Research
state: California
city: Bridgeport
country: United States
facility: Bridgeport Hospital
state: Connecticut
city: Brandon
country: United States
facility: Bay Area Cardiology
state: Florida
city: Daytona Beach
country: United States
facility: Cardiology Associates Research Co.
state: Florida
city: Gainesville
country: United States
facility: Malcom Randall VA Medical Center
state: Florida
city: Hallandale Beach
country: United States
facility: Velocity Clinical Research-Hallandale Beach-67888
state: Florida
city: Jacksonville
country: United States
facility: University of Florida
state: Florida
city: Jacksonville
country: United States
facility: East Coast Institute For Research, LLC
state: Florida
city: Jacksonville
country: United States
facility: First Coast Cardiovascular Institute
state: Florida
city: Jacksonville
country: United States
facility: Jacksonville Center for Clinical Research
state: Florida
city: Miami
country: United States
facility: University of Miami - Miller School of Medicine
state: Florida
city: Palmetto Bay
country: United States
facility: Innovation Medical Research Center
state: Florida
city: Pembroke Pines
country: United States
facility: Suncoast Research Associates, LLC
state: Florida
city: Port Charlotte
country: United States
facility: Peace River Cardiovascular Center
state: Florida
city: Saint Augustine
country: United States
facility: St. Johns Center for Clinical Research
state: Florida
city: Wellington
country: United States
facility: Cardiology Partners Clinical Research Institute
state: Florida
city: Wesley Chapel
country: United States
facility: Cozy Research LLC
state: Florida
city: Winter Park
country: United States
facility: Clinical Site Partners, LLC
state: Florida
city: Columbus
country: United States
facility: Columbus Regional Research Institute
state: Georgia
city: Johns Creek
country: United States
facility: NSC Research Inc
state: Georgia
city: Arlington Heights
country: United States
facility: Northwest Heart Clinical Research, LLC
state: Illinois
city: Chicago
country: United States
facility: Illinois Masonic Hospital
state: Illinois
city: Libertyville
country: United States
facility: Clinical Investigation Specialists, Inc.
state: Illinois
city: Park Ridge
country: United States
facility: AMR Park Ridge
state: Illinois
city: Springfield
country: United States
facility: Springfield Clinic
state: Illinois
city: Elkhart
country: United States
facility: Midwest Cardiovascular Research and Education Foundation
state: Indiana
city: Indianapolis
country: United States
facility: St. Francis Medical Group-Indiana Heart Physicians, Inc
state: Indiana
city: Merrillville
country: United States
facility: Indiana Medical Research Institute
state: Indiana
city: Munster
country: United States
facility: Cardiovascular Research of Northwest Indiana, LLC
state: Indiana
city: Richmond
country: United States
facility: Reid Hospital
state: Indiana
city: West Des Moines
country: United States
facility: The Iowa Clinic, PC
state: Iowa
city: Wichita
country: United States
facility: Robert J Dole Veterans Affairs Medical Center
state: Kansas
city: Wichita
country: United States
facility: West Houston Area Clinical Trial Consultants, LLC
state: Kansas
city: Louisville
country: United States
facility: Norton Healtcare - Norton Heart and Vascular Institute
state: Kentucky
city: Hammond
country: United States
facility: Heart Clinic of Hammond
state: Louisiana
city: Shreveport
country: United States
facility: Grace Research, LLC-Shreveport-64616
state: Louisiana
city: Baltimore
country: United States
facility: Ascension Saint Agnes Heart Care
state: Maryland
city: Beltsville
country: United States
facility: Metropolitan Cardiovascular Consultants
state: Maryland
city: Bay City
country: United States
facility: McLaren Bay Region Medical Center
state: Michigan
city: Farmington Hills
country: United States
facility: Michigan Healthcare Professionals Pulse Cardiology
state: Michigan
city: Ypsilanti
country: United States
facility: Michigan Heart, PC
state: Michigan
city: Saint Paul
country: United States
facility: Regions Hospital
state: Minnesota
city: Jackson
country: United States
facility: Jackson Heart Clinic, P.A.
state: Mississippi
city: Kansas City
country: United States
facility: North Kansas City Hospital
state: Missouri
city: Kansas City
country: United States
facility: Kansas City VA Medical Center
state: Missouri
city: Saint Louis
country: United States
facility: St. Louis Heart and Vascular, P.C.
state: Missouri
city: Omaha
country: United States
facility: Be Well Clinical Studies
state: Nebraska
city: Bridgewater
country: United States
facility: Advanced Heart Care, LLC
state: New Jersey
city: Manalapan
country: United States
facility: Garden State Heart Care, PC
state: New Jersey
city: New York
country: United States
facility: Mount Sinai Hospital-New York-52529
state: New York
city: New York
country: United States
facility: Icahn School of Medicine at Mount Sinai
state: New York
city: Lenoir
country: United States
facility: IMA Clinical Research Lenoir
state: North Carolina
city: Raleigh
country: United States
facility: WakeMed
state: North Carolina
city: Statesville
country: United States
facility: Piedmont Healthcare
state: North Carolina
city: Wilmington
country: United States
facility: Wilmington Health
state: North Carolina
city: Marion
country: United States
facility: K and R Research LLC
state: Ohio
city: Greenville
country: United States
facility: Bon Secours Medical Group Greenville Specialty Care, LLC
state: South Carolina
city: Rapid City
country: United States
facility: Monument Health
state: South Dakota
city: Amarillo
country: United States
facility: Pharmatex Research
state: Texas
city: Amarillo
country: United States
facility: Amarillo Heart Clinical Research Institute, Incorporated
state: Texas
city: Beaumont
country: United States
facility: NextStage Clinical Research
state: Texas
city: Dallas
country: United States
facility: Texas Health Research and Education Institute
state: Texas
city: Dallas
country: United States
facility: Southwest Family Medicine Associates
state: Texas
city: Fort Worth
country: United States
facility: Helios CR Inc - Fort Worth
state: Texas
city: Houston
country: United States
facility: The Methodist Hospital Research Institute
state: Texas
city: Irving
country: United States
facility: DM Clinical Research Dallas
state: Texas
city: Longview
country: United States
facility: DCOL Center for Clinical Research
state: Texas
city: McKinney
country: United States
facility: North Texas Research Associates
state: Texas
city: McKinney
country: United States
facility: Texas Institute Of Cardiology
state: Texas
city: Richmond
country: United States
facility: Accurate Clinical Research, Inc.
state: Texas
city: Tomball
country: United States
facility: Northwest Heart Center
state: Texas
city: Waco
country: United States
facility: NextStage Clinical Research
state: Texas
city: Manassas
country: United States
facility: Carient Heart and Vascular
state: Virginia
city: Norfolk
country: United States
facility: Sentara Norfolk General Hospital
state: Virginia
city: Bahia Blanca
country: Argentina
facility: Inst de Inv Clinicas-Bahia Blanca
city: Bahia Blanca
country: Argentina
facility: Hospital Regional de Bahia Blanca
city: Caba
country: Argentina
facility: CINME - Centro De Investigaciones Metabolicas
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: Hospital Italiano de Buenos Aires
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: Fundacion Favaloro
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: Mautalen- Salud e Investigacion
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: Centro Medico Dra Laura Maffei
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: Glenny Corp. S.A. Bioclinica Argentina
city: Ciudad Autonoma de Buenos Aires
country: Argentina
facility: Centro de Investigaciones y Prevencion Cardiovascular CIPREC
city: Cordoba
country: Argentina
facility: Sanatorio Allende
city: Cordoba
country: Argentina
facility: Clinica Privada Colombo- Fundacion Clinica Colombo
city: Cordoba
country: Argentina
facility: Instituto Médico DAMIC S.R.L.
city: Cordoba
country: Argentina
facility: Centro Medico Luquez
city: Coronel Suarez
country: Argentina
facility: Clinica Coronel Suárez
city: Córdoba
country: Argentina
facility: Well Medica
city: La Plata
country: Argentina
facility: Hospital Italiano de La Plata
city: Mar del Plata
country: Argentina
facility: Centro de Investigaciones Medicas Mar del Plata
city: Pilar
country: Argentina
facility: Hospital Universitario Austral
city: Quilmes
country: Argentina
facility: Instituto Medico CER
city: Quilmes
country: Argentina
facility: Instituto de Investigaciones Clínicas de Quilmes
city: Ramos Mejía
country: Argentina
facility: DIM Clinica Privada
city: Rosario
country: Argentina
facility: INECO Neurociencias Oroño
city: Rosario
country: Argentina
facility: Instituto de Investigaciones Clinicas de Rosario
city: Rosario
country: Argentina
facility: Instituto Medico Fundacion Grupo Colaborativo Rosario Investigacion y Prevencion Medica
city: Rosario
country: Argentina
facility: Sanatorio Parque
city: Rosario
country: Argentina
facility: Instituto CAICI
city: Salta
country: Argentina
facility: Investigaciones Clinicas Salta (ICSAL)
city: Salta
country: Argentina
facility: Centro Cardiovascular Salta
city: San Martin
country: Argentina
facility: Corporacion Medica de Gral. San Martin S.A.
city: San Miguel de Tucuman
country: Argentina
facility: Investigaciones Clinicas Tucuman
city: San Miguel de Tucuman
country: Argentina
facility: Instituto de Cardiologia SRL
city: San Miguel de Tucuman
country: Argentina
facility: Centro Integral de Arritmias Tucuman
city: San Miguel de Tucuman
country: Argentina
facility: Centro Modelo de Cardiologia
city: San Miguel de Tucuman
country: Argentina
facility: Clinica Mayo
city: San Nicolas
country: Argentina
facility: Instituto de Investigaciones Clinicas San Nicolas
city: Santa Fe
country: Argentina
facility: Centro de Investigaciones Clinicas Baigorria
city: Santa Fe
country: Argentina
facility: Hospital "Dr. José Maria Cullen"
city: Santa Fe
country: Argentina
facility: Centro de Investigaciones Clínicas del Litoral
city: Villa Luro
country: Argentina
facility: CEMEDIC - Centro de Especialidades Medicas
city: Dendermonde
country: Belgium
facility: AZ Sint-Blasius
city: Genk
country: Belgium
facility: Ziekenhuis Oost-Limburg - Campus Sint-Jan
city: Gent
country: Belgium
facility: AZ Sint-Lucas
city: Gilly
country: Belgium
facility: Grand Hôpital de Charleroi - Les Viviers
city: Kortrijk
country: Belgium
facility: Kortrijk - HOSP AZ Groeninge Kennedylaan
city: La Louvière
country: Belgium
facility: La Louvière - UNIV CHU Tivoli
city: Liège
country: Belgium
facility: Liège - HOSP CHR de la Citadelle
city: Belo Horizonte
country: Brazil
facility: Hospital Felicio Rocho
city: Belo Horizonte
country: Brazil
facility: Cardresearch Cardiologia Assistencial e de Pesquisas Ltda
city: Brasília
country: Brazil
facility: L2IP -Instituto de Pesquisas Clínicas Ltda.
city: Brasília
country: Brazil
facility: Hospital DF Star
city: Brasília
country: Brazil
facility: CECAP - Centro de Cardiologia Clínica
city: Campina Grande do Sul
country: Brazil
facility: Hospital Angelina Caron
city: Campinas
country: Brazil
facility: IPECC - Instituto de Pesquisa Clínica de Campinas
city: Campinas
country: Brazil
facility: Hospital PUC-Campinas
city: Campinas
country: Brazil
facility: I9 Pesquisas Clinicas - Loema Instituto de Pesquisa Clínica e Consultores SS Ltda
city: Campo Largo
country: Brazil
facility: Hospital do Rocio
city: Caxias do Sul
country: Brazil
facility: Fundacao Universidade de Caxias do Sul
city: Curitiba
country: Brazil
facility: PUC Trials - Núcleo de Pesquisa Clínica da Escola de Medicina da PUC-PR
city: Goiania
country: Brazil
facility: HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás
city: Goiânia
country: Brazil
facility: Via Medica
city: Marília
country: Brazil
facility: ICM - Instituto do Coracao de Marilia
city: Minas Gerais
country: Brazil
facility: Hospital Vera Cruz
city: Natal
country: Brazil
facility: Instituto Atena de Pesquisa Clinica
city: Passo Fundo
country: Brazil
facility: Instituto Mederi de Pesquisa e Saude
city: Porto Alegre
country: Brazil
facility: Hospital de Clínicas de Porto Alegre
city: Porto Alegre
country: Brazil
facility: Irmandade da Santa Casa de Misericórdia de Porto Alegre
city: Porto Alegre
country: Brazil
facility: Universidade Federal do Rio Grande do Sul
city: Porto Alegre
country: Brazil
facility: Hospital Mae de Deus
city: Ribeirão Preto
country: Brazil
facility: Clinicor Clínica Cardiológica LTDA/ Cardio Prime - CENTRO AVANÇADO DE PESQUISA, ESTUDOS E DIAGNÓSTICO (CAPED)
city: Rio de Janeiro
country: Brazil
facility: Instituto Brasil de Pesquisa Clinica (IBPClin)
city: Rio de Janeiro
country: Brazil
facility: Ruschel Medicina e Pesquisa Clínica
city: Rio de Janeiro
country: Brazil
facility: Instituto D'Or Pesquisa e Ensino - Rio de Janeiro
city: Salvador
country: Brazil
facility: Hospital Cardio Pulmonar
city: Santo Andre
country: Brazil
facility: Pesquisare
city: Santo Andre
country: Brazil
facility: Praxis Pesquisa Medica
city: Sao Paulo
country: Brazil
facility: Cpquali Pesquisa Clinica Ltda
city: Sao Paulo
country: Brazil
facility: Centro de Pesquisa Clinica - CPCLIN
city: Sao Paulo
country: Brazil
facility: CEPIC - Centro Paulista de Investigacao Clinica
city: São José do Rio Preto
country: Brazil
facility: Instituto Domingo Braile
city: São José do Rio Preto
country: Brazil
facility: Fundação Faculdade Regional de Medicina de São José do Rio Preto
city: São José dos Campos
country: Brazil
facility: CIPES - Centro Internacional de Pesquisa Clínica
city: Uberlandia
country: Brazil
facility: Eurolatino Pesquisas Médicas Ltda.
city: Vitória
country: Brazil
facility: CEDOES - Diagnóstico e Pesquisa,Vitória
city: Burgas
country: Bulgaria
facility: Medical Center Doktor Staykov Ltd.
city: Dimitrovgrad
country: Bulgaria
facility: Diamedical Medical Center 2013
city: Gabrovo
country: Bulgaria
facility: Medical Center New Polyclinic Gabrovo Ltd.
city: Kardzhali
country: Bulgaria
facility: Medical Center Rodopimed EOOD
city: Kyustendil
country: Bulgaria
facility: MEDICAL CENTER HERA - Kyustendil EOOD
city: Pernik
country: Bulgaria
facility: Ambulatory Individual Practice for Cardiology Specialized Medical Care
city: Pleven
country: Bulgaria
facility: Medical Center Medconsult Pleven LTD
city: Pleven
country: Bulgaria
facility: MHAT Heart and brain
city: Plovdiv
country: Bulgaria
facility: UMHAT Sv.Georgi
city: Sofia
country: Bulgaria
facility: Medical Center For Specialized Medical Help In Cardiovascular Diseases OOD
city: Sofia
country: Bulgaria
facility: National Multiprofile Transport Hospital, Sofia
city: Sofia
country: Bulgaria
facility: Diagnostic Consultative Center Alexandrovska
city: Sofia
country: Bulgaria
facility: University Multidisciplinary Hospital for Active Treatment Sveta Ekaterina EAD
city: Sofia
country: Bulgaria
facility: University Multiprofile Hospital for Active Treatement "Alexandrovska" EAD
city: Sofia
country: Bulgaria
facility: Medical Center Hera EOOD
city: Sofia
country: Bulgaria
facility: MHAT "Tsaritsa Yoanna-ISUL" Clinic of Cardiology, Sofia
city: Sofia
country: Bulgaria
facility: ASOMHIDC - Individual practice "Cardio Tonus" EOOD
city: Sofia
country: Bulgaria
facility: Diagnostic Consultation Center XX-Sofia EOOD
city: Sofia
country: Bulgaria
facility: MHAT "St. Sofia"
city: Sofia
country: Bulgaria
facility: Kalimat Medical Center Ltd.
city: Sofia
country: Bulgaria
facility: Medical Center Intermedica Ltd.
city: Sofia
country: Bulgaria
facility: Medical Center Medicabilis Ltd.
city: Veliko Tarnovo
country: Bulgaria
facility: Medical Centre Nevromedics EOOD
city: Yambol
country: Bulgaria
facility: Multiprofile Hospital For Active Treatment St. Panteleimon Yambol AD
city: Cambridge
country: Canada
facility: Cambridge Cardiac Care Centre
state: Ontario
city: Cambridge
country: Canada
facility: Saul Vizel Medicine Professional Corporation
state: Ontario
city: Hamilton
country: Canada
facility: Premier Clinical Trial Network
state: Ontario
city: Kitchener
country: Canada
facility: Elevate Clinical Research - KMH Hamilton
state: Ontario
city: Mississauga
country: Canada
facility: KMH Cardiology Centres (Mississauga)
state: Ontario
city: Oakville
country: Canada
facility: Oakville Trafalgar Memorial Hospital
state: Ontario
city: Oshawa
country: Canada
facility: James Cha, MD
state: Ontario
city: Peterborough
country: Canada
facility: Kawartha Cardiology Clinical Trials
state: Ontario
city: Sarnia
country: Canada
facility: CardioQuest Research Centre
state: Ontario
city: St. Catharines
country: Canada
facility: Niagara Health System - St. Catharines Site
state: Ontario
city: Sudbury
country: Canada
facility: Health Sciences North
state: Ontario
city: Brossard
country: Canada
facility: ViaCar Recherches Cliniques Inc. (Brossard)
state: Quebec
city: Trois-Rivieres
country: Canada
facility: Diex Recherche (Trois-Rivieres)
state: Quebec
city: St. Jean sur Richelieu
country: Canada
facility: CardioVasc HR Inc.
city: Santiago
country: Chile
facility: Enroll Spa
city: Santiago
country: Chile
facility: CeCim - Centro de Estudios Clinicos e Investigacion Medica
city: Talcahuano
country: Chile
facility: Hospital Las Higueras
city: Talca
country: Chile
facility: Centro de Investigación del Maule
city: Temuco
country: Chile
facility: CECMI Ltda
city: Viña del Mar
country: Chile
facility: CINVEC - Centro de Investigacion Clinica V Reg.,Vina del Mar
city: Beijing
country: China
facility: Beijing AnZhen Hospital
city: Beijing
country: China
facility: Cardiovascular Institute and Fu Wai Hospital
city: Changchun
country: China
facility: Jilin Province People's Hospital
city: Changchun
country: China
facility: The First Hospital of Jilin University
city: Changchun
country: China
facility: China-Japan Union Hospital of Jilin University
city: Changde City
country: China
facility: Changde Second People's Hospital
city: Changsha
country: China
facility: Hunan Province People's Hospital (The First Affiliated Hospital of Hunan Normal University)
city: Changsha
country: China
facility: The Second Xiangya Hospital Of Central South University
city: Changsha
country: China
facility: The Third Hospital of Changsha
city: Chengdu
country: China
facility: People's Hospital of Sichuan Province
city: Chenzhou
country: China
facility: Chenzhou No.1 people's Hospital
city: Chongqing
country: China
facility: Second Affiliated Hospital Chongqing Medical University
city: Chongqing
country: China
facility: Chongqing Three Gorges Central Hospital
city: Dalian
country: China
facility: Affiliated Zhongshan Hospital of Dalian University
city: Deyang
country: China
facility: People's Hospital of Deyang City
city: Foshan
country: China
facility: The First People's Hospital of Foshan
city: Fuzhou
country: China
facility: The First Affiliated Hospital of Fujian Medical University
city: Guangzhou
country: China
facility: The First Affiliated Hospital of Guangzhou University of Chinese Medicine
city: Guangzhou
country: China
facility: Guangdong Provincial People's Hospital
city: Guangzhou
country: China
facility: Third Affiliated Hospital of Guangzhou Medical University
city: Guangzhou
country: China
facility: The Affiliated Panyu Central Hospital of Guangzhou Medical University
city: Guiyang
country: China
facility: Guizhou People's Hospital
city: Haikou
country: China
facility: Hainan General Hospital
city: Harbin
country: China
facility: The First Affiliated Hospital of Harbin Medical University
city: Jiangmen
country: China
facility: Jiangmen Central Hospital
city: Jinan
country: China
facility: Center Hospital of Jinan
city: Lanzhou
country: China
facility: The Second Affiliated Hospital of Lanzhou Medical University
city: Linfen
country: China
facility: Linfen Central Hospital
city: Luoyang
country: China
facility: Luoyang Third People's Hospital
city: Luoyang
country: China
facility: The First Affiliated Hospital of Henan University of Science and Technology
city: Nanchang
country: China
facility: Jiangxi Province Integrated Tractional Chinese Medicine& Western Medicine Hospital
city: Nanchang
country: China
facility: The First Affiliated Hospital of Nanchang University
city: Nanjing
country: China
facility: Zhongda Hospital Southeast University
city: Nanjing
country: China
facility: Nanjing Jiangning Hospital
city: Nanning
country: China
facility: The First Affiliated Hospital of Guangxi Medical University
city: Nanyang
country: China
facility: Nanyang First People's Hospital
city: Nanyang
country: China
facility: Nanyang Second General Hospital
city: Ningbo
country: China
facility: Ningbo Second Hospital
city: Ningbo
country: China
facility: The First Affiliated Hospital of Ningbo University
city: Panjin
country: China
facility: Panjin Liao Oil Gem Flower Hospital
city: Pingxiang
country: China
facility: Pingxiang People's Hospital
city: Shanghai
country: China
facility: Zhongshan Hospital Affiliated to Fudan University
city: Shanghai
country: China
facility: Tongren hospital, Shanghai Jiaotong University School of Medicine
city: Shanghai
country: China
facility: Shanghai General Hospital
city: Shenyang
country: China
facility: Shengjing Hospital of China Medical University
city: Shenyang
country: China
facility: People's Hospital of Liaoning Province
city: Shenzhen
country: China
facility: Shenzhen People's Hospital
city: Shijiazhuang
country: China
facility: The Second Hospital of Hebei Medical University
city: Tai'an
country: China
facility: Taian City Central Hospital
city: Taiyuan
country: China
facility: Shanxi Cardiovascular Hospital
city: Taiyuan
country: China
facility: Shanxi Bethune Hospital
city: Tianjin
country: China
facility: Tianjin Union Medical Center Nankai University Affiliated Hospital
city: Tianjin
country: China
facility: The 2nd Hospital of Tianjin Medical University
city: Wuhan
country: China
facility: Hubei Province Zhongshan Hospital
city: Wuhan
country: China
facility: Renmin Hospital of Wuhan University
city: XI An
country: China
facility: Shaanxi Provincial People's Hospital
city: Xinxiang
country: China
facility: Xinxiang Central Hospital
city: Xuancheng
country: China
facility: The People's Hospital Of Xuancheng City
city: Yinchuan
country: China
facility: The first People's Hosptal of Yinchuan
city: Yueyang
country: China
facility: Yueyang Central Hospital
city: Yuncheng
country: China
facility: Yuncheng Central Hospital
city: Zhangjiakoou
country: China
facility: The First Affiliated Hospital of Hebei North University
city: Zhengzhou
country: China
facility: The First Affiliated Hospital of Zhengzhou University
city: Zhenjiang
country: China
facility: Affiliated Hospital of Jiangsu University
city: Armenia
country: Colombia
facility: Cardiomet CEQUIN S.A.S
city: Barranquilla
country: Colombia
facility: Centro de Investigacion Medico Asistencial S.A.S
city: Barranquilla
country: Colombia
facility: Corazon IPS S.A.S.
city: Bogota
country: Colombia
facility: Fundacion Santa Fe de Bogota
city: Bogota
country: Colombia
facility: Administradora Country S.A.S.
city: Bogota
country: Colombia
facility: Fundacion Hospital Infantil Universitario de San José
city: Cali
country: Colombia
facility: IPS Centro Medico Julián Coronel S.A.
city: Cartagena
country: Colombia
facility: Centro de Diagnostico Cardiologico para la Investigacion Bio
city: Manizales
country: Colombia
facility: IPS médicos internistas de Caldas S.A.S.
city: Santa Marta
country: Colombia
facility: T Y C Inversiones S A S Grupsalud
city: Bilovec
country: Czechia
facility: MUDr. Hana Burianova
city: Brandys nad Labem
country: Czechia
facility: Medicus Services Ltd.
city: Brandýs nad Labem
country: Czechia
facility: Interni Ordinace s.r.o.
city: Brno
country: Czechia
facility: Internal and Cardiology Practice, MUDr. Karel Kamenik, Brno
city: Brno
country: Czechia
facility: Fakultni nemocnice u sv. Anny v Brne
city: Chrudim
country: Czechia
facility: MUDr. Jan Hubac, s.r.o. Kardiologicka ambulance
city: Jaromer
country: Czechia
facility: EDUMED s.r.o.
city: Litovel
country: Czechia
facility: MUDr Petra Maskova PhD
city: Louny
country: Czechia
facility: KardioBusak s.r.o.
city: Marianske Lazne
country: Czechia
facility: InterKardioML s.r.o.
city: Olomouc
country: Czechia
facility: MUDr. Zdenek Vomacka kardiologie a interna s.r.o.
city: Praha 10
country: Czechia
facility: MUDr. Jan KVASNICKA CSc. Angiologie kardiologie a interna
city: Praha 1
country: Czechia
facility: Kardiologie Vinohrady s r o
city: Praha 4
country: Czechia
facility: Institute For Clinical And Experimental Medicine
city: Praha 5
country: Czechia
facility: University Hospital Motol
city: Praha
country: Czechia
facility: Fakultni Thomayerova nemocnice
city: Slany
country: Czechia
facility: Hospital Slany, Internal Department
city: Trutnov
country: Czechia
facility: Kardiologicka ambulance MUDr. Ferkl s.r.o.
city: Uherske Hradiste
country: Czechia
facility: Clinical Trials Services s.r.o
city: Aabenraa
country: Denmark
facility: Sygehus SonderJylland/ Sonderborg
city: Copenhagen NV
country: Denmark
facility: Bispebjerg og Frederiksberg Hospital
city: Copenhagen S
country: Denmark
facility: Amager-Hvidovre Hospital
city: Copenhagen
country: Denmark
facility: Rigshospitalet
city: Herlev
country: Denmark
facility: Herlev and Gentofte Hospital
city: Holbæk
country: Denmark
facility: Holbæk Sygehus
city: Hvidovre
country: Denmark
facility: Hvidovre Hospital
city: Roskilde
country: Denmark
facility: Sjællands Universitetshospital
city: Slagelse
country: Denmark
facility: Slagelse Sygehus
city: Bad Friedrichshall
country: Germany
facility: SLK-Kliniken Heilbronn GmbH
city: Bamberg
country: Germany
facility: Dres. Haas/Kirschner/Wagner
city: Bonn
country: Germany
facility: GFO Kliniken Bonn
city: Bonn
country: Germany
facility: Universitätsklinikum Bonn AöR
city: Coburg
country: Germany
facility: SANA Kliniken Oberfranken Coburg GmbH
city: Erfurt
country: Germany
facility: Helios Klinikum Erfurt
city: Hannover
country: Germany
facility: Medizinische Hochschule Hannover
city: Jena
country: Germany
facility: Universitätsklinikum Jena
city: Kiel
country: Germany
facility: Universitätsklinikum Schleswig-Holstein, Campus Kiel
city: Langen
country: Germany
facility: Asklepios Klinik Langen-Seligenstadt GmbH
city: Lüneburg
country: Germany
facility: Praxis Oedeme
city: Neuwied
country: Germany
facility: Marienhaus Klinikum St. Elisabeth, Neuwied
city: Papenburg
country: Germany
facility: Dr. Andreas Wilke Dr. Andrej Malazhavy und Detelin Lalev Denchev Fachaerzte Innere Medizin und Kardiologie Partnerschaft
city: Regensburg
country: Germany
facility: Universitätsklinikum Regensburg
city: Wallerfing
country: Germany
facility: Gemeinschaftspraxis Dr. Josef Grosskopf und Dr. Wilma Grosskopf
city: Wermsdorf
country: Germany
facility: Kardiologische Praxis, Wermsdorf
city: Bekescsaba
country: Hungary
facility: Belgyogyaszati es Kardiologiai Maganrendelo
city: Budapest
country: Hungary
facility: Buda Hospital of the Hospitaller Order of Saint John of God
city: Budapest
country: Hungary
facility: Obudai Egeszegugyi Centrum
city: Budapest
country: Hungary
facility: Belvaros-Lipotvaros Egeszsegugyi Szolgalat
city: Budapest
country: Hungary
facility: Gottsegen National Cardiovascular Center
city: Budapest
country: Hungary
facility: Semmelweis University
city: Budapest
country: Hungary
facility: Privat Doktor Egeszseguegyi Szolgaltato Zrt.
city: Budapest
country: Hungary
facility: Zugloi Egeszsegugyi Szolgalat
city: Miskolc
country: Hungary
facility: Borsod-Abauj-Zemplen Megyei Korhaz es Egyetemi Oktato Korhaz
city: Miskolc
country: Hungary
facility: IPR Hungary Kft.
city: Mosonmagyarovar
country: Hungary
facility: TaNa Med Kft.
city: Pecs
country: Hungary
facility: Coromed-Smo Kft.
city: Szekszard
country: Hungary
facility: Tolna Varmegyei Balassa Janos Korhaz
city: Zalaegerszeg
country: Hungary
facility: Belvarosi Egeszseghaz Kft.
city: Aurangabad
country: India
facility: Kamal Nayan Bajaj Hospital
city: Bangalore
country: India
facility: Narayana Institute of Cardiac Sciences
city: Bikaner
country: India
facility: S.P. Medical College & Associated Group of Hospitals
city: Chennai
country: India
facility: Tamil Nadu Government Multi Super Speciality Hospital TNGMSSH
city: Chennai
country: India
facility: Apollo Hospitals
city: Gurgaon
country: India
facility: Medanta-The Medicity
city: Kochi
country: India
facility: Lisie Hospital
city: Kolkata
country: India
facility: IPGMER and SSKM Hospital
city: Nashik
country: India
facility: Supe Heart & Diabetes Hospital & Research Centre
city: Nashik
country: India
facility: Chopda Medicare and Research Centre Pvt Ltd
city: New Delhi
country: India
facility: Max Super Speciality Hospital, Delhi
city: Patna
country: India
facility: Indira Gandhi Institute of Medical Sciences
city: Surat
country: India
facility: Nirmal Hospital
city: Surat
country: India
facility: Unicare Heart Institute
city: Vishakhapatnam
country: India
facility: King George Hospital
city: Bergamo
country: Italy
facility: Humanitas Gavazzeni
city: Bergamo
country: Italy
facility: ASST Papa Giovanni XXIII
city: Foggia
country: Italy
facility: Az.Osp. Universitaria "Ospedali Riuniti"
city: Napoli
country: Italy
facility: Azienda Ospedaliera Universitaria "Federico II"
city: Pavia
country: Italy
facility: Fondazione IRCCS Policlinico S. Matteo
city: Pisa
country: Italy
facility: Azienda Ospedaliera Universitaria Pisana
city: Roma
country: Italy
facility: Azienda Ospedaliera Sant'Andrea-Università di Roma La Sapienza
city: Rozzano
country: Italy
facility: Istituto Clinico Humanitas
city: Amagasaki-shi
country: Japan
facility: Hyogo Prefectural Amagasaki General Medical Center
city: Asahi-shi
country: Japan
facility: Asahi General Hospital
city: Fukuoka, Chikushino
country: Japan
facility: Fukuokaken Saiseikai Futsukaichi Hospital
city: Hachioji-shi
country: Japan
facility: Minamino Cardiovascular Hospital
city: Hamada-shi
country: Japan
facility: National Hospital Organization Hamada Medical Center
city: Hamamatsu-shi
country: Japan
facility: JA-Shizuoka Enshu Hospital
city: Himeji-shi
country: Japan
facility: Hyogo Prefectural Harima-Himeji General Medical Center
city: Hiratsuka-shi
country: Japan
facility: Hiratsuka Kyosai Hospital
city: Hitachinaka-shi
country: Japan
facility: Hitachi Ltd. Hitachinaka General Hospital
city: Ishikawa, Kanazawa
country: Japan
facility: National Hospital Organization Kanazawa Medical Center
city: Iwakuni-shi
country: Japan
facility: National Hospital Organization Iwakuni Clinical Center
city: Kamakura-shi
country: Japan
facility: Tokushukai Shonan Kamakura General Hospital
city: Kanagawa, Fujisawa
country: Japan
facility: Shonan Fujisawa Tokushukai Hospital
city: Kanagawa, Miura-gun
country: Japan
facility: Tokushukai Hayama Heart Center
city: Kanonji-shi
country: Japan
facility: Mitoyo General Hospital
city: Kasama-shi
country: Japan
facility: Ibaraki Prefectural Central Hospital
city: Kasugai-shi
country: Japan
facility: Kasugai Municipal Hospital
city: Kawaguchi-shi
country: Japan
facility: Saiseikai Kawaguchi Hospital
city: Kishiwada-shi
country: Japan
facility: Tokushukai Kishiwada Tokushukai Hospital
city: Kobe-shi
country: Japan
facility: National Hospital Organization Kobe Medical Center
city: Kumamoto-shi
country: Japan
facility: Kumamoto University Hospital
city: Kumamoto-shi
country: Japan
facility: Japanese Red Cross Kumamoto Hospital
city: Kure
country: Japan
facility: National Hospital Organization Kure Medical Center and Chugoku Cancer Center
city: Matsudo-shi
country: Japan
facility: Chibanishi General Hospital
city: Matsumoto-shi
country: Japan
facility: Shinshu University Hospital
city: Matsuyama-shi
country: Japan
facility: Ehime Prefectural Central Hospital
city: Matsuyama-shi
country: Japan
facility: Matsuyama Shimin Hospital
city: Meguro-ku
country: Japan
facility: National Hospital Organization Tokyo Medical Center
city: Mito-shi
country: Japan
facility: Mito Saiseikai General Hospital
city: Miyagi, Sendai
country: Japan
facility: Sendai Cardiovascular Center
city: Nagasaki, Nagasaki
country: Japan
facility: Nagasaki Harbor Medical Center
city: Nagoya-shi
country: Japan
facility: Nagoya Kyoritsu Hospital
city: Nakano-shi
country: Japan
facility: Hokushin General Hospital
city: Okayama, Okayama
country: Japan
facility: Juzenkai The Sakakibara Heart Institute of Okayama
city: Ome-shi
country: Japan
facility: Ome Municipal General Hospital
city: Omura-shi
country: Japan
facility: Nagasaki Medical Center
city: Osaka-shi
country: Japan
facility: Osaka Metropolitan University Hospital
city: Osaka-shi
country: Japan
facility: Osaka General Medical Center
city: Saitama, Saitama
country: Japan
facility: Kosekai Iwatsuki-minami Hospital
city: Sakai-shi
country: Japan
facility: Osaka Rosai Hospital
city: Sapporo-shi
country: Japan
facility: Teine Keijinkai Hospital
city: Sendai-shi
country: Japan
facility: NHO Sendai Medical Center
city: Shimonoseki-shi
country: Japan
facility: NHO Kanmon Medical Center
city: Suita-shi
country: Japan
facility: National Cerebral and Cardiovascular Center
city: Suita-shi
country: Japan
facility: The University of Osaka Hospital
city: Tachikawa-shi
country: Japan
facility: Tachikawa Hospital
city: Takasaki-shi
country: Japan
facility: National Hospital Organization Takasaki General Medical Center
city: Tanabe-shi
country: Japan
facility: NHO Minami Wakayama Medical Center
city: Tokushima-shi
country: Japan
facility: Tokushima Prefectural Central Hospital
city: Tomakomai-shi
country: Japan
facility: Tomakomai City Hospital
city: Toyota-shi
country: Japan
facility: Toyota Memorial Hospital
city: Ueda-shi
country: Japan
facility: NHO Shinshu Ueda Medical Center
city: Yokohama-shi
country: Japan
facility: Yokohama Sakae Kyosai Hospital
city: Busan
country: Korea, Republic of
facility: Inje University Busan Paik Hospital
city: Busan
country: Korea, Republic of
facility: Dong-A University Hospital
city: Busan
country: Korea, Republic of
facility: Pusan National University Yangsan Hospital
city: Gwangju
country: Korea, Republic of
facility: Chonnam National University Hospital
city: Incheon
country: Korea, Republic of
facility: Gachon University Gil Medical Center
city: Seongnam
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
city: Seoul
country: Korea, Republic of
facility: Severance Hospital
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
city: Seoul
country: Korea, Republic of
facility: Korea University Guro Hospital
city: Wonju-si, Gangwon State
country: Korea, Republic of
facility: Yonsei University Wonju Severance Christian Hospital
city: Aguascalientes
country: Mexico
facility: Hospital Cardiologica Aguascalientes
city: Culiacan
country: Mexico
facility: Centro Especializado de Investigación Medical Group Culiacan
city: Culiacan
country: Mexico
facility: Centro para el Desarrollo de la Medicina y de Asistencia Medica Especializada S.C.
city: Guadalajara
country: Mexico
facility: Cardiologia Clinica e Intervencionista
city: Irapuato
country: Mexico
facility: Proactive CR Mexico S.A. de C.V.
city: Mazatlan
country: Mexico
facility: Centro de Estudios de Alta Especialidad de Sinaloa CEAES
city: Monterrey
country: Mexico
facility: Cardiolink Clin Trials S.C.
city: Monterrey
country: Mexico
facility: Hospital Universitario Dr Jose Eleuterio Gonzalez
city: México
country: Mexico
facility: Clinstile S.A. de C.V.
city: Queretaro
country: Mexico
facility: Centro de Estudios Clinicos de Queretaro S.C
city: Tijuana
country: Mexico
facility: Centro de Investigacion Cardiovascular y Metabolica
city: Torreon
country: Mexico
facility: CIMAB S.A. de C.V.
city: 's-HERTOGENBOSCH
country: Netherlands
facility: Jeroen Bosch Ziekenhuis-Hertogenbosch
city: Amsterdam
country: Netherlands
facility: Amsterdam University Medical Center
city: Eindhoven
country: Netherlands
facility: Catharina Ziekenhuis
city: Groningen
country: Netherlands
facility: Universitair Medisch Centrum Groningen
city: Maastricht
country: Netherlands
facility: Maastricht University
city: Nieuwegein
country: Netherlands
facility: St. Antonius ziekenhuis, locatie Nieuwegein
city: Zwolle
country: Netherlands
facility: Isala Zwolle
city: Bielsko-Biala
country: Poland
facility: American Heart Of Poland Sp. Z O.O.
city: Bydgoszcz
country: Poland
facility: INTERCORE Medical Center
city: Bydgoszcz
country: Poland
facility: Pratia Bydgoszcz Clinical Research Site
city: Bydgoszcz
country: Poland
facility: NZOZ Medical Center KERmed
city: Gdansk
country: Poland
facility: Poradnia Kardiologiczna Jaroslaw Jurowiecki
city: Gdynia
country: Poland
facility: Medical Centre Pratia Gdynia
city: Krakow
country: Poland
facility: Specjalistyczna Praktyka Lekarska Ewa Mirek-Bryniarska
city: Kraków
country: Poland
facility: Linden Sp. z o.o. sp.k.
city: Kraków
country: Poland
facility: Pratia MCM Krakow
city: Legnica
country: Poland
facility: Beata Miklaszewicz & Dariusz Dabrowski Cardiamed Sp. j.
city: Lodz
country: Poland
facility: Santa Sp. z o.o. Santa Familia PTG Lodz
city: Lublin
country: Poland
facility: Velocity Lublin
city: Lublin
country: Poland
facility: Zanamed Medical Clinic Sp. z o.o.
city: Piaseczno
country: Poland
facility: NZOZ HEUREKA, Piaseczno
city: Plock
country: Poland
facility: CBK Med Clinic SP Z O O
city: Rzeszow
country: Poland
facility: MEDYK Medical Center
city: Siedlce
country: Poland
facility: Lukmed Lukasz Wozniak
city: Skierniewice
country: Poland
facility: Velocity Skierniewice Sp. z o.o
city: Skórzewo
country: Poland
facility: Centrum Medyczne Pratia Poznan
city: Staszow
country: Poland
facility: Velocity Staszow
city: Warsaw
country: Poland
facility: ETG Warszawa
city: Warszawa
country: Poland
facility: Balsammedica Sp. z o. o.
city: Warszawa
country: Poland
facility: MTZ Clinical Research Powered by Pratia
city: Wroclaw
country: Poland
facility: 4. Military Clinical Hospital with Polyclinic SP ZOZ
city: Wroclaw
country: Poland
facility: Sedimed Sp. z o.o.
city: Zarow
country: Poland
facility: NZOZ Centrum Medyczne SERAFIN-MED Halina Serafin
city: Baia Mare
country: Romania
facility: Spitalul Judetean De Urgenta Dr. Constantin Opris Baia Mare
city: Balotesti
country: Romania
facility: Spitalul Clinic De Urgenta Prof Dr Agrippa Ionescu
city: Braila
country: Romania
facility: Spitalul Judetean de Urgenta Braila
city: Brasov
country: Romania
facility: S.C.Centrul Medical Unirea S.R.L.
city: Brasov
country: Romania
facility: Spitalul Clinic Judetean de Urgenta Brasov
city: Bucharest
country: Romania
facility: Emergency University Hospital, Bucharest
city: Bucuresti
country: Romania
facility: Clinica Medicala Data Plus SRL
city: Cluj-Napoca
country: Romania
facility: Cluj Napoca Clinical County Hospital
city: Cluj-Napoca
country: Romania
facility: Spitalul Angiocare SRL
city: Craiova
country: Romania
facility: Emergency County Hospital Craiova
city: Oradea
country: Romania
facility: Spitalul Clinic Judetean de Urgenta Bihor
city: Pitesti
country: Romania
facility: Sal Med Srl
city: Suceava
country: Romania
facility: U 2 Serv Com Srl
city: Targu Mures
country: Romania
facility: Cmi Dr. Podoleanu Cristian
city: Targu Mures
country: Romania
facility: Spitalul Clinic Judetean de Urgenta Targu Mures
city: Targu-Mures
country: Romania
facility: Country Clinical Emergency Hospital, Targu-Mures
city: Timisoara
country: Romania
facility: S.C Medicali's S.R.L
city: Timisoara
country: Romania
facility: Timisoara Municipal Emergency Clinical Hospital
city: Al Ahsa
country: Saudi Arabia
facility: King AbdulAziz University Hospital
city: Dammam
country: Saudi Arabia
facility: King Fahad Specialist Hospital - Research Center
city: Riyadh
country: Saudi Arabia
facility: King Faisal Specialist Hospital and Research Center
city: Riyadh
country: Saudi Arabia
facility: King Fahad Medical City
city: Belgrade
country: Serbia
facility: Clinical Center " Dr Dragisa Misovic Dedinje"
city: Belgrade
country: Serbia
facility: University Clinical Center of Serbia
city: Kragujevac
country: Serbia
facility: University Clinical Center of Kragujevac
city: Niska Banja
country: Serbia
facility: Institute for Treatment and Rehabilitation, Niska Banja
city: Nis
country: Serbia
facility: University Clinical Center Nis
city: Pancevo
country: Serbia
facility: General Hospital Pancevo
city: Smederevo
country: Serbia
facility: General Hospital Sveti Luka
city: Sremska Kamenica
country: Serbia
facility: Institute of Cardiovascular Diseases of Vojvodine
city: Zajecar
country: Serbia
facility: Health Centre Zajecar
city: Banska Bystrica
country: Slovakia
facility: Kardiointerna s r o
city: Banska Bystrica
country: Slovakia
facility: Stredoslovensky Ustav Srdcovych A Cievnych Chorob A S
city: Bardejov
country: Slovakia
facility: Alian s.r.o.
city: Bratislava
country: Slovakia
facility: Cliniq s.r.o.
city: Bratislava
country: Slovakia
facility: Nemocnica AGEL Zvolen a s
city: Bratislava
country: Slovakia
facility: Premedix Clinic
city: Brezno
country: Slovakia
facility: Nemocnica s poliklinikou Brezno n.o.
city: Kosice
country: Slovakia
facility: Medical Group Kosice s.r.o
city: Kosice
country: Slovakia
facility: KARDIO R s r o
city: Kosice
country: Slovakia
facility: CARDIO D&R spol.s.r.o. Kosice
city: Lucenec
country: Slovakia
facility: KARDIO 1 s.r.o.
city: Lucenec
country: Slovakia
facility: Kardiomed s.r.o.
city: Martin
country: Slovakia
facility: Kvc-Kardiovaskularne Centrum
city: Nitra
country: Slovakia
facility: Cardiocenter Nitra, s.r.o
city: Nove Zamky
country: Slovakia
facility: Cardioamb s.r.o
city: Barcelona
country: Spain
facility: Hospital Vall Hebron
city: Barcelona
country: Spain
facility: Hospital Clínic de Barcelona
city: Madrid
country: Spain
facility: Hospital General Universitario Gregorio Marañón
city: Madrid
country: Spain
facility: Hospital Universitario 12 de Octubre
city: Madrid
country: Spain
facility: Hospital La Paz
city: Malaga
country: Spain
facility: Hospital Virgen de la Victoria
city: Sanlucar de Barrameda
country: Spain
facility: Hospital Virgen del Camino
city: Santiago de Compostela
country: Spain
facility: Complexo Hospitalario Universitario De Santiago
city: Torrejón de Ardoz
country: Spain
facility: Pratia ES Hospital Universitario de Torrejon
city: Valencia
country: Spain
facility: Hospital Clínico de Valencia
city: Valencia
country: Spain
facility: Hospital General Universitario de Valencia
city: Valencia
country: Spain
facility: Hospital Politècnic La Fe
city: Villamartin
country: Spain
facility: Hospital Virgen de las Montañas, Villamartin
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Medical University Chung-Ho Memorial Hospital
city: Kaohsiung
country: Taiwan
facility: E-Da Hospital
city: Taichung
country: Taiwan
facility: Taichung Veterans General Hospital
city: Taipei City
country: Taiwan
facility: Taipei Medical University Hospital
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hospital
city: Taipei
country: Taiwan
facility: Tri-Service General Hospital
city: Taipei
country: Taiwan
facility: Chang-Hua Christian Hospital
city: Adana
country: Turkey
facility: Cukurova Universitesi Tip Fakultesi Gog. Hast. Anabilim Dali
city: Ankara
country: Turkey
facility: Etlik City Hospital
city: Erzurum
country: Turkey
facility: Ataturk Universitesi Tip Fakultesi
city: Eskisehir
country: Turkey
facility: Osmangazi Uni Medical Faculty
city: Gaziantep
country: Turkey
facility: Gaziantep University Medical Faculty Sahinbey Educational Research Hospital
city: Istanbul
country: Turkey
facility: Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi
city: Istanbul
country: Turkey
facility: Medical Park Pendik Hospital
city: Izmir
country: Turkey
facility: Dokuz Eylul University Faculty of Medicine
city: Kutahya
country: Turkey
facility: Kutahya Health Science University Evliya Celebi Research and Training Hospital
city: Malatya
country: Turkey
facility: Inonu Uni. Med. Fac., Battalgazi
city: Mersin
country: Turkey
facility: Mersin University Medical Faculty
city: Uskudar / Istanbul
country: Turkey
facility: Siyami Ersek Heart Hospital
city: Bristol
country: United Kingdom
facility: Southmead Hospital
city: Chichester
country: United Kingdom
facility: St Richard's Hospital
city: Exeter
country: United Kingdom
facility: Royal Devon and Exeter Hospital, Wonford
city: Halifax
country: United Kingdom
facility: Calderdale Royal Hospital
city: London
country: United Kingdom
facility: St Bartholomew's Hospital
city: Ha Noi
country: Vietnam
facility: Hanoi Heart Hospital
city: Hanoi
country: Vietnam
facility: Bach Mai hospital
city: Hanoi
country: Vietnam
facility: Tam Anh General Hospital
city: Ho Chi Minh City
country: Vietnam
facility: Nguyen Tri Phuong Hospital
city: Ho Chi Minh city
country: Vietnam
facility: Tam Anh HCMC
city: Ho Chi Minh
country: Vietnam
facility: Military Hospital 175
city: Ho Chi Minh
country: Vietnam
facility: Thong Nhat Hospital HCMC
city: Ho Chi Minh
country: Vietnam
facility: Cho Ray Hospital
city: Ho Chi Minh
country: Vietnam
facility: University Medical Center HCMC
city: Ho Chi Minh
country: Vietnam
facility: Trung Vuong Hospital
Study officials:
References: