Clinical trial NCT01529398: Sensorimotor Training Versus Resistance Training in Patients With Knee Osteoarthritis
Official title: Efficacy of a Sensorimotor Training in Patients With Knee Osteoarthritis: a Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
PHASE3
Conditions: Knee Osteoarthritis
Keywords: knee osteoarthritis
exercise therapy
resistance training
proprioception
Lead sponsor: Federal University of São Paulo
Sponsor class: OTHER
First posted: 2012-02-08
Enrollment: 96
Sex: ALL
Minimum age (years): 50
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: People with knee osteoarthritis (OA) have functional instability and defective neuromuscular function, it was recently suggested that sensorimotor exercises may be important and needed to improve the effectiveness of training programs for these patients. This study objective was to compare the effectiveness of a supervised resistance muscular training (RT) versus sensorimotor training (SMT) for patients with Knee OA, on decrease of pain and functional improvement.


Eligibility criteria: Inclusion Criteria:

* Patients diagnosed with tibiofemoral osteoarthritis;
* Both genders;
* Age\> 50 years \<75 years;
* Completion of clinical and radiological criteria of the American College of Rheumatology (ACR) criteria for knee OA;
* No physical activity in the previous 3 months;
* Education level from the 4th grade of primary school.

Exclusion Criteria:

* uncontrolled hypertension;
* decompensated diabetes mellitus;
* uncontrolled thyroid diseases;
* cardiorespiratory disease (ischemia, arrhythmia, chest pain, or exercise-induced bronchospasm), liver abnormalities;
* Patients with grade IV functional limitation that needed devices to walk(Kellgren-Lawrence radiographic classification);
* Patients in a period of sick leave by the INSS or any other related factor;
* Other rheumatic diseases.

Primary outcomes:
measure: Visual analogue scale of pain (VAS)
timeFrame: 16 weeks
measure: Get Up and Go Test
timeFrame: 16 weeks
Secondary outcomes:
measure: Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)
timeFrame: 16 weeks
measure: electromyographic analysis of quadriceps muscle (EMG)
timeFrame: 16 weeks
measure: isometric quadriceps strength
timeFrame: 16 weeks
measure: Medical Outcomes Study Short Form (SF-36)
timeFrame: 16 weeks
measure: Berg Balance Test
timeFrame: 16 weeks
measure: Tinetti Test
timeFrame: 16 weeks
measure: activities of daily living scale (ADLS)
timeFrame: 16 weeks
Other outcomes:
Locations:
city: São Paulo
country: Brazil
facility: Department of Rheumatology and Physiotherapy of Interlagos Ambulatory - Santo Amaro University
Study officials:
affiliation: Federal University of São Paulo and Santo Amaro University
name: Virginia FM Trevisani, MD, MS, PhD
role: STUDY_DIRECTOR
affiliation: Federal University of São Paulo
name: Maria S Peccin, PT, MS, PhD
role: STUDY_CHAIR
affiliation: Federal University of São Paulo
name: Marcelo Abrahão, PT
role: STUDY_CHAIR
affiliation: Federal University of São Paulo
name: Alvaro N Atallah, MD, PhD
role: STUDY_DIRECTOR
affiliation: Federal University of São Paulo
name: Aline B Gomiero, PT
role: PRINCIPAL_INVESTIGATOR
affiliation: Federal University of São Paulo
name: Andrea H Kayo, PT, MS
role: STUDY_CHAIR
References:
citation: Fitzgerald GK, Piva SR, Gil AB, Wisniewski SR, Oddis CV, Irrgang JJ. Agility and perturbation training techniques in exercise therapy for reducing pain and improving function in people with knee osteoarthritis: a randomized clinical trial. Phys Ther. 2011 Apr;91(4):452-69. doi: 10.2522/ptj.20100188. Epub 2011 Feb 17.
citation: Fitzgerald GK, Childs JD, Ridge TM, Irrgang JJ. Agility and perturbation training for a physically active individual with knee osteoarthritis. Phys Ther. 2002 Apr;82(4):372-82.
citation: Diracoglu D, Aydin R, Baskent A, Celik A. Effects of kinesthesia and balance exercises in knee osteoarthritis. J Clin Rheumatol. 2005 Dec;11(6):303-10. doi: 10.1097/01.rhu.0000191213.37853.3d.
citation: Fransen M, McConnell S. Exercise for osteoarthritis of the knee. Cochrane Database Syst Rev. 2008 Oct 8;(4):CD004376. doi: 10.1002/14651858.CD004376.pub2.
citation: Gomiero AB, Kayo A, Abraao M, Peccin MS, Grande AJ, Trevisani VF. Sensory-motor training versus resistance training among patients with knee osteoarthritis: randomized single-blind controlled trial. Sao Paulo Med J. 2018 Jan-Feb;136(1):44-50. doi: 10.1590/1516-3180.2017.0174100917. Epub 2017 Dec 7.