Clinical trial NCT06013397: Effectiveness of Ketogenic Diet in MELAS Syndrome
Official title: Clinical Trial of Ketogenic Diet in the Treatment of Mitochondrial Encephalomyopathy With Lactic Acidosis and Stroke-like Episodes(MELAS)
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: MELAS Syndrome
Ketogenic Dieting
Lead sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University
Sponsor class: OTHER
First posted: 2023-08-28
Enrollment: 100
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The goal of this clinical trial is to evaluate the effectiveness of ketogenic diet in patients with MELAS syndrome. The main questions it aims to answer are:

Clarify the curative effects of ketogenic diet in the treatment of MELAS disease.

Prevent the aggravation of MELAS disease, and improve the quality of life of patients.

Provide reliable evidence-based medical basis for the clinical application of ketogenic diet in the treatment of MELAS syndrome patients.

The clinical data of the participants treated with ketogenic diet will be collected, including the completion of ketogenic diet and clinical data at the start of treatment and after 1 month, 3 months, 6 months and 12 months

Detailed description: Ketogenic diet initiation and follow-up:

1. Before starting ketogenic diet treatment, patients with abnormal indexes such as liver, kidney, lipid, humoral immunity, hematuria, routine biochemical, electrolyte, trace elements and bone metabolism should be excluded, energy and nutrients should be calculated according to their height and weight, and patients will be taught with ketogenic diet treatment education
2. Patients were initiated ketogenic diet after a short period of fasting (fasting no more than 48 hours). After treatment was initiated, 13 of the calculated target energy was given on the first day, 23 of the target energy was given on the second day, and the target amount was reached on the third day. Nutritionists made appropriate adjustments to the target energy according to the level of blood keto measured by patients
3. Weekly follow-up via telemedicine system or social media, outpatient follow-up at the initiation of ketogenic therapy and at 1 month, 3 months, 6 months, and 12 months respectively. Outpatient follow-up was done in a joint clinic with a dietitian and a neurologist to evaluate the effects and side effects of ketogenic therapy on a compliant diet and related clinical examinations

Clinical data collection:

1. Demographic information and Medical history collection Gender, age, education level age of onset, genetic test, drug use, past history, personal history, family history
2. Clinical symptom collection According to the Newcastle Mitochondrial Disease Adult Scale(NMDAS), including migraine headaches, seizures, stroke-like episodes and etc.
3. Biochemical indicators Blood glucose, keto, lactate and pyruvate monitoring, dietary status, dietary ratio changes, energy changes, weight changes
4. Cognitive function assessment Cognitive function was assessed using Fepsy software
5. Diagnostic Examination Cranial MRI, scalp EEG

Eligibility criteria: Inclusion Criteria:

* Patients who meet the diagnostic criteria of MELAS and have received MELAS standard therapy but are not satisfied with the therapeutic effect, and voluntarily underwent ketogenic therapy

Exclusion Criteria:

* Diseases with porphyria and disturbances in fatty acid transport and oxidation, severe electrolyte metabolism abnormalities, severe hemodynamic instability, acute respiratory infections, uncontrolled systemic infections, severe liver and renal failure, cholesterolemia (\>300mgdl), abnormal coagulation, acute pancreatitis, eating disorders, ketogenic diet intolerance, significant weight loss, poor compliance

Primary outcomes:
measure: Change from Baseline Clinical Symptom Score in 1 Year
timeFrame: Baseline, 1 month, 3 months, 6 months and 12 months
measure: Change from Baseline Biochemical indicators in 1 Year
timeFrame: Baseline, 1 month, 3 months, 6 months and 12 months
measure: Change from Baseline Biochemical indicators in 1 Year
timeFrame: Baseline, 1 month, 3 months, 6 months and 12 months
measure: Hamilton Anxiety Scale (HAMA)
timeFrame: Baseline, 1 month, 3 months, 6 months and 12 months
measure: Hamilton Depression Scale(HAMD
timeFrame: Baseline, 1 month, 3 months, 6 months and 12 months
measure: Wechsler Intelligence Scale(WISC)
timeFrame: Baseline, 1 month, 3 months, 6 months and 12 months
measure: Mini-mental State Examination(MMSE)
timeFrame: Baseline, 1 month, 3 months, 6 months and 12 months
measure: Change from Baseline Diagnostic Examination in 1 Year
timeFrame: Baseline, 1 month, 3 months, 6 months and 12 months
Secondary outcomes:
measure: Demographic Information and Medical History Collection
timeFrame: Baseline
Other outcomes:
Locations:
city: Hangzhou
country: China
facility: Second Affiliated Hospital, School of Medicine, Zhejiang University
state: Zhejiang
Study officials:
affiliation: Second Affiliated Hospital, School of Medicine, Zhejiang University
name: Shuang Wang, doctor
role: PRINCIPAL_INVESTIGATOR
References: