Clinical trial NCT06124170: Improved Pain Management in Knee Osteoarthritis-related Surgeries
Official title: Evaluating the Effectiveness of Continuously Improved Pain Management in Knee Osteoarthritis-related Surgeries
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Knee Osteoarthritis
Total Knee Arthroplasty
Unicompartmental Knee Arthroplasty
High Tibial Osteotomy
Pain Management
Lead sponsor: Sichuan Provincial People's Hospital
Sponsor class: OTHER
First posted: 2023-11-09
Enrollment: 714
Sex: ALL
Minimum age (years): 50
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The medical records of 714 patients (142 men, 40 women; mean age: 38.5 years; age range: 18-64 years) with moderate or severe knee OA who had undergone TKA (n=551), UKA (n=92), or HTO (n=71) in a group of joint surgery at Sichuan Provincial People's Hospital between March 2016 and February 2022 were retrospectively analyzed. Clinical data, including age, weight, height, anesthesia grade, surgery, and time, as well as continuously improved perioperative pain management measures, were recorded.

Brief summary: In recent years, pain management coordinated with enhanced recovery after surgery (ERAS) has been widely applied and rapidly developed in orthopedics, showing promising prospects. Since 2016, our hospital has used a series of continuously improved pain management schemes for patients with knee OA who underwent total knee arthroplasty (TKA), unicompartmental knee arthroplasty (UKA), and high tibial osteotomy (HTO). Here, we retrospectively analyze these patients' clinical data to compare the effects of different pain intervention measures during the perioperative period on postoperative pain, functional exercise, hospital stay, and prognosis of the three surgical methods in an attempt to provide a feasible solution for pain management of these patients.

Detailed description: We retrospectively analyzed the clinical data of patients with knee osteoarthritis (OA) who received surgical treatment to provide a feasible solution for perioperative pain management of these patients. The medical records of 714 patients with knee OA who had undergone total knee arthroplasty (n=551), unicompartmental knee arthroplasty (n=92) and high tibial osteotomy (n=71) were retrospectively analyzed and the cases were divided into Groups A, B, and C, according to the continuously optimized pain management. Clinical data including anesthesia grade, surgery time, functional exercise, hospital stay, pain, emotion, complications and prognosis were compared.

Eligibility criteria: Inclusion Criteria:

* first knee surgery were 50-80 years old had complete clinical and follow-up data

Exclusion Criteria:

* American Society of Anesthesiologists Physical Status grade≥4 comorbidity with three or more systemic diseases long-term anxiety and depression, contraindications of painkillers, long-term alcoholism, or taking painkillers concomitant limb pain caused by spinal degeneration

Primary outcomes:
measure: visual analogue score (VAS)
timeFrame: 24 hours after surgery
measure: visual analogue score (VAS)
timeFrame: 72 hours after surgery
Secondary outcomes:
measure: Quadriceps muscle strength
timeFrame: 24 hours after surgery
measure: Quadriceps muscle strength
timeFrame: 72 hours after surgery
measure: Scope of activities to knee joint
timeFrame: 24 hours after surgery
measure: Scope of activities to knee joint
timeFrame: 72 hours after surgery
Other outcomes:
measure: Self-Rating Anxiety Scale (SAS)
timeFrame: 24 hours after surgery
measure: Self-Rating Anxiety Scale (SAS)
timeFrame: 72 hours after surgery
measure: Self-Rating Depression Scale (SDS)
timeFrame: 24 hours after surgery
measure: Self-Rating Depression Scale (SDS)
timeFrame: 72 hours after surgery
Locations:
city: Chengdu
country: China
facility: Sichuan Provincial People's Hospital
state: Sichuan
Study officials:
References: