louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06534736: Effects of Scapular Stabilization Exercises Combined With Post Facilitation Stretch in Patients With Upper Cross Syndrome: A Randomized Control Trial
Official title: Effects of Scapular Stabilization Exercises Combined With Post Facilitation Stretch in Patients With Upper Cross Syndrome: A Randomized Control Trial
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Upper Cross Syndrome
Lead sponsor: Foundation University Islamabad
Sponsor class: OTHER
First posted: 2024-08-02
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: This is a randomized controlled trial having two groups.Sample will be divided into two groups , Group A and Group B.Group A i.e Control group will receive Post Faciliation Stretch only for 4 weeks on alternative days.Group B i.e intervention hgroup will undergo Scapular Stabilization exercises along with post facilitation stretch for 4 weeks on alternative days
Primary purpose: TREATMENT

Brief summary: Upper Cross Syndrome is characterized by the postural deviation of head , neck , shoulders and altered muscular muscular activation which included weakness of rhomboids , middle and lower trapezius and serratus anterior and tightness of upper trapezius , pectorallis and levator scapulae . It is a combinaton of scapular dyskinesia , forward head posture , rounded shoulder and thoracic kyphosis.This study aims to assess the enduring effects scapular stabilization exercises along with post facilitation stretch on Upper Cross Syndrome with the goal of preventing its reoccurrence over time, If there are improved results by the combination of both treatments than any of them alone , then it can used in combination for better results on patients


Eligibility criteria: Inclusion Criteria

* Aged 18 to 45 with neck pain for more than 3 months
* Both genders males and females
* NPRS scoring of greater than or equal to 4 points
* No History of serious pathology or recent neck trauma
* Diagnosed Upper Cross Syndrome cases using Janda approach

Exclusion Criteria

* Known Scapular or shoulder pathology
* Cervical and thoracic fractures , dislocations or surgeries or whiplash injury

Primary outcomes:
measure: pain intensity
timeFrame: 4 weeks
measure: Neck Disability
timeFrame: 4 weeks
measure: Cervical Range of Motion
timeFrame: 4 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Rawalpindi
country: Pakistan
facility: Foundation University College of Physical Therapy
state: Punjab
Study officials:
References:
Clinical trial NCT06972836: Safety and Efficacy of Awake Uniportal Video Assisted Thoracoscopic Modified Pericardial Window in Recurrent Pericardial Effusion at Mid Term Result
Official title: Safety and Efficacy of Awake Uniportal Video Assisted Thoracoscopic Modified Pericardial Window in Recurrent Pericardial Effusion at Mid Term Result
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Awake Thoracoscope
Pericardial Effusion
Pericadiopleural Window
Keywords: pericardial effusion
pericardiopleural window
Lead sponsor: Zagazig University
Sponsor class: OTHER_GOV
First posted: 2025-05-15
Enrollment: 36
Sex: ALL
Minimum age (years): 25
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: this study compare two surgical techniues at the same time two methods of anathesia with assisstance of thoracoscope for cases of repeated collection of fluid in pericardial sac and observation the result of the two techniques on the operated patients from 3 to 6 months

Detailed description: this study compare two thoracoscopic techniues awake modified pericardial window and pericardial window under general anasethia for cases of repeated collection of fluid in pericardial sac and observation the result of the two techniques on the operated patients from 3 to 6 months

Eligibility criteria: Inclusion Criteria:

* patients who presented with recurrent massive pericardial effusion based on clinical, radiological evidence by Echo and C.T. chest

Exclusion Criteria:

* hemodynamically unstable patients

Primary outcomes:
measure: recurrence of pericardial effusion
timeFrame: follow up each month at out patient clinic for 6 months from the date of surgery
measure: Awake anasethia
timeFrame: from the start till the end of the procedure about 45 min
Secondary outcomes:
Other outcomes:
Locations:
city: Zagazig,,
country: Egypt
facility: cardiothorathic surgery department -faculty of medecine-zagazig univeristy- Egypt
state: El Sharkia
city: Zagazig
country: Egypt
facility: Amr El Sayed Tawfek
state: El Sharkia
Study officials:
affiliation: cardiothoracic surgery department-faculty of medecine-zagazig univeristy-Egypt
name: Amr Tawfek, as prof
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02483936: Efficacy and Safety of Olmesartan Associated With Chlorthalidone Versus Benicar HCT® in Essential Hypertension Control
Official title: Efficacy and Safety Evaluation of the New Association on Fixed Dose of Olmesartan Medoxomil + Chlorthalidone (40mg + 12.5mg and 40mg + 25mg) Compared With BENICAR HCT® in Hypertension Control
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: PHASE3
Conditions: Arterial Hypertension
Lead sponsor: EMS
Sponsor class: INDUSTRY
First posted: 2015-06-29
Enrollment: 348
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the non-inferiority clinical efficacy of two different drug associations in the essential hypertension control.


Eligibility criteria: Inclusion Criteria:

* Signed Consent of the patient;
* Participants with decompensated essential hypertension, classified into stage 1 (with high or very high cardiovascular risk), stage 2 or stage 3 according to the Brazilian Society of Cardiology (2010), who are being treated with monotherapy.

Exclusion Criteria:

* Patients with any clinically significant disease that in the investigator opinion can not participate in the study;
* Secondary hypertension diagnosis or blood pressure above 190x100 mmHg in the screening/randomization visit;
* Morbid obesity or immunocompromised patients;
* Participants with greater than 10 mmHg difference in the measurements of systolic or diastolic blood pressure between the two arms;
* Participants who do not have the two upper limbs;
* Participants with important electrocardiographic changes;
* Creatinine clearance - less than 60 mL / min;
* History of hypertensive emergencies and cardiovascular and / or moderate to severe cerebrovascular events in the past 6 months;
* Microalbuminuria urine sample greater than 30 mg/g;
* Patients with history of hypersensitivity to any of the formula compounds;
* Pregnancy or risk of pregnancy and lactation patients;
* Participation in clinical trial in the year prior to this study;

Primary outcomes:
measure: Efficacy of essential hypertension control based on the reduction of systolic blood pressure at the end of the study.
timeFrame: 60 days
Secondary outcomes:
measure: Safety will be evaluated by the adverse events occurrences
timeFrame: 9 weeks
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT06612736: Nutritional Management of Neurologically Impaired Children Across China
Official title: Real World Evidence Study: Improving Nutritional Management of Neurologically Impaired Children
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Neurological Impairments
Keywords: neurological impairment
enteral nutrition
children
nutritional management
Lead sponsor: Shanghai Jiao Tong University School of Medicine
Sponsor class: OTHER
First posted: 2024-09-25
Enrollment: 586
Sex: ALL
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Children with neurological impairments across China

Brief summary: A retrospective study to (1) investigate clinical characteristics, nutritional status, and nutritional management in neurologically impaired children in China, (2) assess whether enteral nutrition (particularly tube feeding) contributes to improving nutritional outcomes in children with neurological impairments, (3) examine the tolerability of enteral nutrition and whether it can effectively reverse or prevent severe malnutrition.

Detailed description: Electronic health records of children with neurological impairments from 11 medical centers across China between 2015 and 2020 were reviewed. Data were analyzed using SPSS 22.0. Normally distributed data were presented as mean±standard deviation (SD), and non-normally distributed data were presented as median and interquartile range (IQR). Categorical data were presented as frequencies and analyzed using the chi-square test. The Wilcoxon test was used to compare data at different time points. Multivariate logistic regressions were used to analyze the factors influencing gastrointestinal symptoms.

Eligibility criteria: Inclusion Criteria:

(1) age≤18 years, (2) with primary, progressive or non-progressive neurological impairment, (3) received oral nutrition or tube feeding, (4) for tube-fed patients only: at least 1 month of nutritional intervention and at least 1 follow-up visit (i.e. at least at Visit 1)

Exclusion Criteria:

with acquired causes of neurological damage (e.g., traumatic brain injury) or tube-fed patients who received nutritional intervention for less than a month and without follow-up

Primary outcomes:
measure: Weight for age z-score
timeFrame: From diagnosis to 24 months of follow-up
measure: Height for age z-score
timeFrame: From diagnosis to 24 months of follow-up
measure: BMI for age z-score
timeFrame: From diagnosis to 24 months of follow-up
Secondary outcomes:
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine
state: Shanghai
Study officials:
affiliation: Shanghai Children's Medical Center Affiliated to Shanghai Jiaotong University School of Medicine
name: Li Hong, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01060813: Study of the Benefit of Exercise and Aminoacid Supplements in Cirrhotic Patients
Official title: Study of the Benefit of Exercise and Aminoacid Supplements in Cirrhotic Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cirrhosis
Keywords: cirrhosis
exercise
leucin
glutamine synthetase
Lead sponsor: Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Sponsor class: OTHER
First posted: 2010-02-02
Enrollment: 17
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This is a pilot study including 20 cirrhotic patients that will be randomized to receive during 3 months leucine vs leucine plus a programme of physical exercise specially designed for cirrhotic patients. The hypothesis is that physical exercise in cirrhotic patients could increase muscle mass (and therefore glutamine synthetase activity leading to a higher blood ammonium clearance) and quality of life. Safety of physical exercise in cirrhotic patients will be strictly assessed.


Eligibility criteria: Inclusion Criteria:

* compensated liver cirrhosis.

Exclusion Criteria:

* hepatocellular carcinoma,
* active alcoholism (less than 1 year),
* decompensated cirrhosis,
* variceal bleeding less than 3 months,
* contraindication for exercise.

Primary outcomes:
measure: glutamine synthetase activity
timeFrame: three months
Secondary outcomes:
measure: quality of life
timeFrame: three months
Other outcomes:
Locations:
city: Barcelona
country: Spain
facility: Hospital de la Santa Creu i Sant Pau
Study officials:
affiliation: Department of Gastroenterology, Hospital de la Santa Creu i Sant Pau
name: German Soriano, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06253013: CHARM-COPD Program of Care
Official title: A Program of Care in Chronic Obstructive Pulmonary Disease Involving Virtual Pulmonary Rehabilitation, Integrated Care and Remote Clinical Monitoring After Discharge From a Recent Exacerbation: Mixed-Methods Study on Feasibility
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Chronic Obstructive Pulmonary Disease
Keywords: Remote Clinical Monitoring
COPD
Wearables
Digital Health
Self-management
Lead sponsor: University Health Network, Toronto
Sponsor class: OTHER
Collaborators: name: The Salvation Army Toronto Grace Health Centre
name: University of Toronto
First posted: 2024-02-12
Enrollment: 100
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: The investigators' goal for this project is to evaluate the feasibility, acceptability, and actual usage of a program of care for patients with COPD recently discharged after an acute exacerbation. The program of care includes virtual pulmonary rehabilitation, integrated care, and remote clinical monitoring.

Detailed description: The investigators' goal for this project is to evaluate the feasibility, acceptability, and actual usage of a multimodal, individualized program of care for patients with COPD recently discharged from hospital with an acute exacerbation. The program will combine elements of existing standards of care at two institutions, Toronto Grace Health Centre and University Health Network, with emerging technologies.

The investigators want to determine whether the program is considered appropriate and useful to both patients and health care providers, and whether it is feasible to implement. The investigators also want to determine whether it is feasible to conduct a large-scale randomized control trial of the program. The investigators will also explore whether each intervention reduces re-admissions to hospital.

Eligibility criteria: Inclusion Criteria:

* Referred to either Virtual Pulmonary Rehabilitation or Remote Clinical Monitoring at Toronto Grace Health Centre after discharge from UHN hospital with an AECOPD as defined by the clinical team

Exclusion Criteria:

* Pulmonary condition other than COPD as the main respiratory disease such as bronchiectasis or asthma
* Projected life expectancy ≤ 2 months , as determined by the clinical team
* Significant cognitive impairment and absence/inability of a family caregiver to consent and to follow study processes

Primary outcomes:
measure: Feasibility of the program and research study
timeFrame: 90 days
measure: Acceptability by patients and clinicians
timeFrame: 90 days
measure: Actual usage over 90 days
timeFrame: 90 days
Secondary outcomes:
measure: Readmissions within 30 days
timeFrame: 30 days
Other outcomes:
Locations:
city: Toronto
country: Canada
facility: University Health Network
state: Ontario
Study officials:
affiliation: University Health Network, Toronto
name: Robert Wu, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06836713: Paulista Cardiovascular Surgery Registry I
Official title: Surgical Risk Stratification As an Instrument for Innovation in Cardiac Surgery Programs in the Unified Health System of the São Paulo State
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Health Sciences
Medicine
Surgery
Lead sponsor: University of Sao Paulo General Hospital
Sponsor class: OTHER
Collaborators: name: University of Campinas, Brazil
First posted: 2025-02-20
Enrollment: 5222
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients undergoing cardiac surgery (coronary artery bypass grafting and/or heart valve surgery)

Brief summary: Cardiovascular diseases represent the greatest burden of morbidity and mortality for the health system and cardiac surgery has an important impact on their resolutivity. The association and correlation of patients' demographic and clinical relevant information with the resources required for each stratum represent the possibility to adapt, improve and innovate into the healthcare programs. This project aims to remodel the "InsCor" risk score for the formulation of the SP- SCORE (Sao Paulo System for Cardiac Operative Risk Evaluation) in order to better reflects the complexity of cardiac surgical care, The participating hospitals include the Health Technology Assessment Centers in of the Health Secretarlat'HTA Network of São Paulo State (HTA-NATSs / SES-SP). The SP-SCORE will use 10 variables of the InsCor model and others 8 variables with presumed influence in Brazil. The primary endpoints are morbidity and mortality. This project will contribute for the SUS- SP regionalized health-care (RRAS) sustainability and financing of the CABG and/or heart valve surgery programs promoting equitable allocation, increasing access and effectiveness, as well as characterizing the magnitude of available resources and its impact. (AU)


Eligibility criteria: Inclusion Criteria:

* Patients who underwent isolated coronary artery bypass grafting (CABG) surgery, mitral valve surgery, aortic valve surgery, combined mitral + aortic valve surgery, and CABG + heart valve surgery

Exclusion Criteria:

* Patients operated on in an emergency or rescue situation and who underwent percutaneous or transcatheter procedures were excluded from this analysis.

Primary outcomes:
measure: Hospital mortality
timeFrame: Mortality until 30 days after the susrgical procedure
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: instituto do Coração, Hospital das Clinicas HCFMUSP, Faculdade de Medicina, Universidade de SaoPaulo, Sao Paulo, SP, BR
name: Luiz Augusto F Lisboa, PhD
role: STUDY_DIRECTOR
name: Nakazone
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00398736: A Non-invasive Approach to the Assessment of Volume Status in Mechanically Ventilated Septic Patients.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Severe Sepsis
Septic Shock
Keywords: Presence of severe sepsis and septic shock, mechanical ventilation
Lead sponsor: Charite University, Berlin, Germany
Sponsor class: OTHER
First posted: 2006-11-14
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Critically ill patients with sepsis

Brief summary: To evaluate the use of sonographic inferior caval vein assessment in mechanically ventilated septic patients.

Volume assessment in mechanically ventilated patients with inflammation is of major importance to guide fluid therapy. The researchers investigated whether measurement of caval vein diameter correlates with invasively assessed volume-based hemodynamic parameters.


Eligibility criteria: Inclusion Criteria:

* age 18-90
* presence of severe sepsis and septic shock
* invasive hemodynamic monitoring using the picco system

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Charite University Medicine
name: Joerg C Dr. Schefold, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06407336: Comparative Effect of Cylindrical Lenses Verses Spherical Equilient on Contrast Sensitivity
Official title: Comparative Effect of Cylindrical Lenses Verses Spherical Equilient on Contrast Sensitivity
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Low Vision Aids
Lead sponsor: Superior University
Sponsor class: OTHER
First posted: 2024-05-09
Enrollment: 68
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: the concept of spherical equivalent plays a pivotal role in simplifying the prescription and enhancing communication between eye care professionals and patients. The spherical equivalent is a calculated value that condenses the spherical and cylindrical components into a single power.

Detailed description: Mathematically, it is determined by adding half of the cylindrical power to the spherical power (SE = Sphere + (Cylinder/2)). This calculated value serves as a convenient representation of the overall refractive error, aiding in a more straightforward understanding of the prescription. Understanding their individual and collective impact on contrast sensitivity opens up new avenues for refining corrective interventions and enhancing the overall quality of vision. This article aims to demystify the intricate relationship between spherical equivalent and cylindrical correction, and their collective impact on contrast sensitivity.

Eligibility criteria: Inclusion Criteria:

* Patients within 18 to 35 years will be included.
* Both genders will be included.
* Patients having astigmatism will be included.
* Patients having 6/6 corrected vision will be included.
* Eyes having no other ocular pathology will be included.
* Patients having no history of ocular surgery or corneal scar will be included.

Exclusion Criteria:

* i. Eyes having any ocular pathology will be excluded.
* Patients with corneal suture will be excluded.
* Those using contact lenses instead of spectacles for vision correction will be excluded.
* Participants with a history of eye surgery within the past year will be excluded.

Primary outcomes:
measure: Contrast sensitivity
timeFrame: 12 Months
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Sehat Medical Complex Hanjarwal
state: Punjab
Study officials:
References: