Clinical trial NCT05220371: Influence of Specific Collagen Peptides on Recovery After Exercise Induced Muscle Damage
Official title: Influence of Specific Collagen Peptides on Parameters of Biomechanical and Systemic Recovery After Exercise-induced Muscle Damage
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Recovery
Keywords: Collagen peptides
Concurrent training
Ultrasound
MVC
RFD
Lead sponsor: University of Vienna
Sponsor class: OTHER
Collaborators: name: CRI Collagen Research Institute GmbH
First posted: 2022-02-02
Enrollment: 50
Sex: MALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The present study aims at investigating the potential influence of specific collagen peptides on recovery after exercise induced muscle damage with focus on long-term effects.


Eligibility criteria: Inclusion Criteria:

* No subjective symptoms during physical exertion
* Stable weight and dietary behaviour
* Body Mass Index (BMI) between 18.5 and 24.9
* No extensive strength/endurance sports so far (less than 3 h/week)
* No complaints during strenuous physical activity

Exclusion Criteria:

* Circumstances that impair/prevent sporting activity (e.g. chronic heart disease, arrhythmia, heart valve disease, arthritis etc.)
* Intolerance/aversion to animal protein
* Arterial hypertension (high blood pressure) (syst \> 200 mmHg and/or diast \> 105 mmHg) at rest
* Presence of insulin-dependent diabetes mellitus
* Liver and/or kidney disease that precludes a high protein load
* Collagen supplementation or regular intake of other dietary supplements in the last 6 months.

Primary outcomes:
measure: Change in maximal voluntary contraction (MVC)
timeFrame: Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
measure: Change in rate of force development (RFD)
timeFrame: Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
measure: Change in countermovement jump height (CMJ)
timeFrame: Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
measure: Change in subjective pain score
timeFrame: Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
measure: Change in Achilles tendon cross-sectional area
timeFrame: Baseline and after 12 weeks
measure: Change in Vastus Lateralis fibre length
timeFrame: Baseline (pre, post, 24 hours, 48 hours) and after 12 weeks (pre, post, 24 hours, 48 hours)
measure: Change in collagen related blood markers
timeFrame: Baseline (pre, post, 2 hours, 24 hours, 48 hours) and after 12 weeks (pre, post, 2 hours, 24 hours, 48 hours)
measure: Change in Achilles tendon echo intensity
timeFrame: Baseline and after 12 weeks
measure: Change in Vastus Lateralis echo intensity
timeFrame: Baseline and after 12 weeks
measure: Change in body composition parameters (fat mass, fat-free mass, extracellular mass, body cell mass)
timeFrame: Baseline and after 12 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Vienna
country: Austria
facility: University of Vienna, Institute of Sport Science
Study officials:
affiliation: University of Vienna, Institute of Sport Science
name: Daniel Koenig, Prof. Dr.
role: PRINCIPAL_INVESTIGATOR
References: