louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05029752: Feasibility of Digital Thermal Monitoring to Assess Endothelium-Dependent Vasodilation in Patients Undergoing Hematopoietic Cell Transplantation (HCT)
Official title: Feasibility of Digital Thermal Monitoring to Assess Endothelium-Dependent Vasodilation in Patients Undergoing Hematopoietic Cell Transplantation (HCT)
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Vascular
Endothelial
Endothelial Dysfunction
Endothelix
Lead sponsor: M.D. Anderson Cancer Center
Sponsor class: OTHER
First posted: 2021-09-01
Enrollment: 27
Sex: ALL
Minimum age (years): 6
Maximum age (years): 26
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The Vendys II, an FDA-approved device, uses finger digital thermal monitoring (DTM) after a period of blood flow restriction to evaluate vascular health. This study will evaluate the feasibility of using this device to measure the Vascular Reactivity Index (VRI) in children and adolescents/young adults (AYA) undergoing hematopoietic cell transplantation (HCT).

Detailed description: Primary Objective:

-Assess the feasibility of the use of VENDYS-II in children and AYA as a measure of vascular endothelial function, where feasibility is defined as completion of the evaluation by at least 70% of consented participants.

Secondary Objective:

-Summarize the incidence of any adverse events that precludes completion of assessment of endothelium-dependent vasodilation using the Vendys II in children and AYA.

Eligibility criteria: Inclusion Criteria for HCT candidates:

* Children, adolescents and young adults (AYA) 6-26 years of age who are HCT candidates
* Recipients within 30 days prior to or within 14 days after autologous and allogeneic HCT.

  -. Any preparative regimen.
* Willing and eligible to enroll on PA19-0756

Inclusion Criteria for Healthy Donors:

- Healthy HCT donors between the ages of 6-26 years of age.

Exclusion Criteria:

* Any subject who does not consent/assent to participation.

  -. Any subject with an injury or deformation to the index finger which prevents proper fit of the device.
* Any subject with skin toxicity or neuropathy which prevents comfortable use of the device.

Primary outcomes:
measure: The use of VENDYS-II in children and AYA as a measure of vascular endothelial function.
timeFrame: through study completion, an average of 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Houston
country: United States
facility: M D Anderson Cancer Center
state: Texas
Study officials:
affiliation: M.D. Anderson Cancer Center
name: Keri Schadler
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01716052: Women's Mammography Study To Improve Comfort During Mammography
Official title: Women's Mammography Study Attempting to Improve the Comfort During Screening Mammography CTRC#11-45
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Pain
Keywords: Mammogram
Ibuprofen
Pain management
Lead sponsor: The University of Texas Health Science Center at San Antonio
Sponsor class: OTHER
First posted: 2012-10-29
Enrollment: 2
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to determine in a randomized trial whether it is possible to decrease the discomfort of mammography by using the analgesic ibuprofen, or by using a scripted, supportive text informing patients about mammography.

Detailed description: This study is designed to evaluate two methods of reducing pain and discomfort caused by mammography, one of the barriers to the procedure.

Eligibility criteria: Inclusion Criteria:

* Must have signed the informed consent.
* Must either be getting her first mammogram or based on prior experience be expecting level 4 or 5 pain

Exclusion Criteria:

* May not have taken ibuprofen or other pain medication within the last 12 hours.
* Must not have a contraindication for taking ibuprofen e.g:
* No history of allergic reactions to ibuprofen or aspirin
* No recent history with the last year of bleeding from GI tract
* Not pregnant or suspected of being pregnant

Primary outcomes:
measure: Measure of Discomfort of Mammography
timeFrame: 3 years
Secondary outcomes:
Other outcomes:
Locations:
city: San Antonio
country: United States
facility: Cancer Therapy and Research Center at UTHSCSA
state: Texas
Study officials:
affiliation: University of Texas
name: Kenneth Kist, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02039752: Asan Multivessel Registry
Official title: Asan Medical Center Registry for Multivessel
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Coronary Artery Disease
Keywords: Multivessel
Lead sponsor: Asan Medical Center
Sponsor class: OTHER
Collaborators: name: CardioVascular Research Foundation, Korea
First posted: 2014-01-20
Enrollment: 25000
Sex: ALL
Minimum age (years): 19
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with multivessel disease from 1995 in Asan Medical Center

Brief summary: The purpose of this study is to evaluate long-term prognoses of patients with multivessel coronary disease treated medically or surgically or percutaneously in real world practice.


Eligibility criteria: Inclusion Criteria:

* Patients with multivessel disease from 1995 in Asan Medical Center
* Age 19 and more

Exclusion Criteria:

* For prospective cohort, not agreeing to participate with written informed consent form

Primary outcomes:
measure: composite event
timeFrame: 1year
Secondary outcomes:
measure: Death
timeFrame: 1year
measure: Myocardial Infarction
timeFrame: 1year
measure: Stroke
timeFrame: 1year
measure: Revascularization
timeFrame: 1year
measure: Angina symptom
timeFrame: 1year
measure: Bleeding
timeFrame: 1year
measure: Re-hospitalization
timeFrame: 1year
measure: Stent thrombosis
timeFrame: 1year
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center
Study officials:
References:
citation: Kim TO, Kang DY, Ahn JM, Kim SO, Lee PH, Lee J, Kim JH, Kim HJ, Kim JB, Choo SJ, Chung CH, Lee JW, Park SJ, Park DW; Asan Medical Center-Multivessel Revascularization Registry Investigators. Prognostic Impact of Mildly Impaired Renal Function in Patients Undergoing Multivessel Coronary Revascularization. J Am Coll Cardiol. 2022 Apr 5;79(13):1270-1284. doi: 10.1016/j.jacc.2022.01.035.
citation: Kim TO, Ahn JM, Kang DY, Park H, Kim SO, Lee PH, Lee J, Kim JH, Jeong YJ, Yang Y, Hyun J, Kim HJ, Kim JB, Choo SJ, Chung CH, Lee JW, Park SJ, Park DW; Asan-Multivessel Registry Investigators. Long-Term Outcomes After Percutaneous Coronary Intervention With Second-Generation Drug-Eluting Stents or Coronary Artery Bypass Grafting for Multivessel Coronary Disease. Am J Cardiol. 2021 Dec 1;160:21-30. doi: 10.1016/j.amjcard.2021.08.047. Epub 2021 Oct 3.
Clinical trial NCT05668052: A Cross-sectional Study of Covid-19 Pandemic in Zhejiang Province
Official title: A Cross-sectional Study of Covid-19 Pandemic in Zhejiang Province
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Cross-sectional Study
COVID-19 Pandemic
Keywords: Cross-sectional study
COVID-19 Pandemic
Lead sponsor: The First Affiliated Hospital of Zhejiang Chinese Medical University
Sponsor class: OTHER
First posted: 2022-12-29
Enrollment: 500
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: patients with Covid-19

Brief summary: this study adopted a cross-sectional study, collected the medical history and symptoms of patients infected with Covid-19 through a questionnaire survey, and made statistical analysis, so as to provide better clinical guidance.

Detailed description: Recently, there has been an outbreak of covid-19 in Zhejiang Province. In order to comprehensively understand the condition of patients with covid-19 in Zhejiang Province, this study adopted a cross-sectional study, collected the medical history and symptoms of patients infected with Covid-19 through a questionnaire survey, and made statistical analysis, so as to provide better clinical guidance.

Eligibility criteria: Inclusion Criteria:

* A positive nucleic acid test for Covid-19, or a positive antigen test for novel coronavirus, no age limit.

Exclusion Criteria:

* Unable to understand the contents of the questionnaire for various reasons

Primary outcomes:
measure: characters of patients with Covid-19
timeFrame: baseline
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT05415852: Lasers in Onychomycosis
Official title: Comparison Between Different Types of LASER in the Treatment of Onychomycosis, a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Onychomycosis
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2022-06-13
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Onychomycosis is the most common nail disease, representing more than 50% of all onychopathies. Future studies on the absorption spectra of dermatophyte fungi will be needed to develop lasers that effectively exploit absorption differences in fungi and dermal tissue.

Detailed description: Treatments with antifungals may not be successful due to several factors, including the long time required to apply topical medications, the side effects of systemic drugs, and the application of insufficient medication to the target area. Even with adequate systemic or topical therapy, the persistence of fungal infections is not uncommon. In light of these limitations, laser therapy has been proposed as an alternative option for onychomycosis therapy.

Eligibility criteria: Inclusion Criteria:

* Patients with onychomycosis.

Exclusion Criteria:

* Patients with excessive manual work

Primary outcomes:
measure: Onychomycosis severity index
timeFrame: change from baseline at 3 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03205852: Patients Decision-making in Rotator Cuff Surgery
Official title: Do we Really Allow Patient Decision-making in Rotator Cuff Surgery? A Prospective Randomized Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Rotator Cuff Disease
Lead sponsor: Hospital del Mar
Sponsor class: OTHER
First posted: 2017-07-02
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CROSSOVER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients with diagnosis of rotator cuff tears documented by MRI

Brief summary: The objective of this study was to evaluate the effect on patient treatment decision-making if information was given based on the benefit or on the side effect in rotator cuff disorders.


Eligibility criteria: Inclusion Criteria:

* patients diagnosed with rotator cuff tears at their first clinical visit

Exclusion Criteria:

* patients with a previous shoulder surgery, patients with worker's compensation and patients who were unwilling to participate and thereby not sign informed consent

Primary outcomes:
measure: questionnaire of surgery decision
timeFrame: immediate
Secondary outcomes:
measure: Constant Score
timeFrame: immediate
Other outcomes:
Locations:
Study officials:
References:
citation: Torrens C, Miquel J, Santana F. Do we really allow patient decision-making in rotator cuff surgery? A prospective randomized study. J Orthop Surg Res. 2019 Apr 29;14(1):116. doi: 10.1186/s13018-019-1157-2.
Clinical trial NCT03972852: Establishment of an Anaesthetic Protocol for Examinations for Children With Glaucoma or Suspected Glaucoma
Official title: Establishment of an Anaesthetic Protocol for Examinations Under Anaesthesia for Children With Glaucoma or Suspected Glaucoma - Correlation of Bispectral Index (BIS) and Intraocular Pressure (IOP)
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Anesthesia
Intraocular Pressure
Glaucoma, Suspect
Pediatric Glaucoma
Lead sponsor: Johannes Gutenberg University Mainz
Sponsor class: OTHER
First posted: 2019-06-04
Enrollment: 120
Sex: ALL
Minimum age (years): 5
Maximum age (years): 10
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Children with glaucoma or suspected glaucoma for ophthalmological examination or surgery

Brief summary: Correct measurement of the intraocular pressure of children with glaucoma or suspected glaucoma is essential for diagnosis and therapy.

Despite new non-invasive measurement methods most of the children are uncooperative during the ophthalmological examination. Therefore examination under anaesthesia is needed.

A lot of perioperative factors influence the measurement of intraocular pressure.

Established and safe anaesthetic regimes have been modified regarding these factors. Aim of the study is to evaluate, if a standardized anaesthetic protocol generates reliable and reproducible measured values.


Eligibility criteria: Inclusion Criteria:

* Indication for a general anesthesia (laryngeal mask) and ophthalmological examination and probably surgery
* Children with glaucoma or suspected glaucoma
* ASA classification I-III
* written informed consent of the legal representatives

Exclusion Criteria:

* Contraindication for a laryngeal mask airway
* Known allergy to propofol or remifentanil

Primary outcomes:
measure: Correlation of depth of anesthesia an intraocular pressure
timeFrame: 1 day
Secondary outcomes:
measure: Bland Altmann Correlation of Applanation tonometry and rebound tonometry
timeFrame: 1 day
measure: Normal range of pediatric intraocular pressure
timeFrame: 1 day
measure: Correlation of the corneal thickness and the intraocular pressure
timeFrame: 1 day
Other outcomes:
Locations:
city: Mainz
country: Germany
facility: Johannes Gutenberg - Universität
state: Rhineland Palatinate
Study officials:
References:
citation: Pirlich N, Grehn F, Mohnke K, Maucher K, Schuster A, Wittenmeier E, Schmidtmann I, Hoffmann EM. Anaesthetic protocol for paediatric glaucoma examinations: the prospective EyeBIS Study protocol. BMJ Open. 2021 Oct 5;11(10):e045906. doi: 10.1136/bmjopen-2020-045906.
Clinical trial NCT03556852: CARBETOCIN VERSUS RECTAL MISOPROSTOL FOR MANAGEMENT OF THIRD STAGE OF LABOR IN WOMEN AT LOW RISK OF POSTPARTUM HEMORRHAGE
Official title: CARBETOCIN VERSUS RECTAL MISOPROSTOL FOR MANAGEMENT OF THIRD STAGE OF LABOR IN WOMEN AT LOW RISK OF POSTPARTUM HEMORRHAGE
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Postpartum Hemorrhage
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2018-06-14
Enrollment: 150
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 39
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: 150 pregnant women admitted for spontaneous, induced or augmented vaginal delivery and categorized as low risk for postpartum hemorrhage (PPH) were divided randomly into two groups. Carbetocin group (C) received 1 ampoule of Carbetocin (100 μg/ml) (Pabal®, Draxis/Multipharma, Egypt, under license from DRAXIS PHARMA-Canada) added to 10 cc saline and given IV after the delivery of the baby. Misoprostol group (M) received 2 rectal misoprostol tablets (800 μg) (Misotac; SIGMA Pharm, Cairo, Egypt) after the delivery of the baby. Blood samples were tested to measure hemoglobin levels upon admission to the labor room and 12 hours after delivery

Detailed description: 150 pregnant women admitted for spontaneous, induced or augmented vaginal delivery and categorized as low risk for postpartum hemorrhage (PPH) were divided randomly into two groups. Carbetocin group (C) received 1 ampoule of Carbetocin (100 μg/ml) (Pabal®, Draxis/Multipharma, Egypt, under license from DRAXIS PHARMA-Canada) added to 10 cc saline and given IV after the delivery of the baby. Misoprostol group (M) received 2 rectal misoprostol tablets (800 μg) (Misotac; SIGMA Pharm, Cairo, Egypt) after the delivery of the baby. Blood samples were tested to measure hemoglobin levels upon admission to the labor room and 12 hours after delivery

Eligibility criteria: Inclusion Criteria:

singleton pregnancy 36-40 weeks of gestation vertex presentation. normotensive hemoglobinlevel \> 10 gm/dl

• Noncomplicated pregnancy

Exclusion Criteria:

* Women with history of Postpartum hemorrhage in previous deliveries uterine fibroids previous cesarean section medical disorders (e.g. diabetes, anemia, coagulation disorders, cardiac, hepatic and renal diseases) antepartum hemorrhage

Primary outcomes:
measure: prevention of post partum hemorrhage after vaginal delivery
timeFrame: 24 hours after delivery
Secondary outcomes:
measure: drugs side effects
timeFrame: 24 hours after delivery
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Kasr Alainy medical school
Study officials:
affiliation: professor
name: Ahmed Maged
role: PRINCIPAL_INVESTIGATOR
References:
citation: Maged AM, Waly M, Fahmy RM, Dieb AS, Essam A, Salah NM, Hussein EA, Nabil H. Carbetocin versus rectal misoprostol for management of third stage of labor among women with low risk of postpartum hemorrhage. Int J Gynaecol Obstet. 2020 Feb;148(2):238-242. doi: 10.1002/ijgo.13056. Epub 2019 Dec 2.
Clinical trial NCT00185952: Nifedipine vs Placebo for Maintenance Tocolysis of Preterm Labor.
Official title: Nifedipine for the Maintenance Tocolysis of Preterm Labor: Comparison to Placebo in a Prospective, Randomized Double Blind Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Obstetric Labor, Premature
Venous Thrombosis
Lead sponsor: Stanford University
Sponsor class: OTHER
Collaborators: name: Santa Clara Valley Health & Hospital System
First posted: 2005-09-16
Enrollment: 70
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Comparing nifedipine to placebo for the maintenance tocolysis of preterm labor

Detailed description: To estimate whether maintenance nifedipine tocolysis after arrested preterm labor prolongs pregnancy and improves neonatal outcomes.

Eligibility criteria: Inclusion Criteria:

- arrested preterm labor

Exclusion Criteria:

- ruptured membranes, fetal distress, placenta previa, placental abruption, maternal medical contraindication to tocolysis

Primary outcomes:
measure: Achieving 37 weeks gestation
timeFrame: delivery
Secondary outcomes:
measure: Incidence of recurrent preterm labor
timeFrame: Delivery
measure: Neonatal outcomes
timeFrame: Discharge of neonate
Other outcomes:
Locations:
city: Stanford
country: United States
facility: Stanford University School of Medicine
state: California
Study officials:
affiliation: Stanford University
name: Yasser Yehia El-Sayed
role: PRINCIPAL_INVESTIGATOR
References:
citation: Lyell DJ, Pullen KM, Mannan J, Chitkara U, Druzin ML, Caughey AB, El-Sayed YY. Maintenance nifedipine tocolysis compared with placebo: a randomized controlled trial. Obstet Gynecol. 2008 Dec;112(6):1221-1226. doi: 10.1097/AOG.0b013e31818d8386.
citation: Wilson A, Hodgetts-Morton VA, Marson EJ, Markland AD, Larkai E, Papadopoulou A, Coomarasamy A, Tobias A, Chou D, Oladapo OT, Price MJ, Morris K, Gallos ID. Tocolytics for delaying preterm birth: a network meta-analysis (0924). Cochrane Database Syst Rev. 2022 Aug 10;8(8):CD014978. doi: 10.1002/14651858.CD014978.pub2.
Clinical trial NCT06476652: Effect of Simple Simulator-based Training on Initial Performance of Novices Iultrasound-guided Adductor Canal Block
Official title: Effect of Simple Simulator-based Training on Initial Performance of Novices in Ultrasound-guided Adductor Canal Block
Study type: OBSERVATIONAL
Overall status: ENROLLING_BY_INVITATION
Conditions: Anesthesia
Lead sponsor: Prince of Songkla University
Sponsor class: OTHER
First posted: 2024-06-26
Enrollment: 12
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: we choose First-year anesthesiology residents in faculty of medicine, PSU

Brief summary: This prospective descriptive study is effect of simple simulator-based training on initial performance of novices in ultrasound-guided adductor canal block. The main question is Can we improve performance on simple simultor-based training ultrasound-guide adductor canal block?. We evaluate in First-year residents in Anesthesiology, Faculty of medicine, PSU.


Eligibility criteria: Inclusion Criteria:

* First-year anesthesiology residents in faculty of medicine, PSU

Exclusion Criteria:

* Residents with previous experience in ultrasound-guide adductor canal block

Primary outcomes:
measure: The efficiency of using a simple model for injecting local anesthesia through the adductor canal under ultrasound guidance assessed by Design and Validation Regional Anaesthesia Procedural skill Assessment tool
timeFrame: 1 year
Secondary outcomes:
measure: satisfaction and confidence in teaching assessed by pre- and post-test, satisfaction questions
timeFrame: 1 year
Other outcomes:
Locations:
city: Hat Yai
country: Thailand
facility: Department of Anesthesiology, Faculty of Medicine, Prince of Songkla University
state: Songkla
Study officials:
affiliation: Department of Anesthesiology, Faculty of Medicine, Prince of Songkla University
name: Teerawat Krongyut
role: PRINCIPAL_INVESTIGATOR
References: