Clinical trial NCT05308433: Cybersickness imAgiNg Olfactory Evocation
Official title: Cybersickness imAgiNg Olfactory Evocation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Keywords: fMRI
Lead sponsor: Central Hospital, Nancy, France
Sponsor class: OTHER
First posted: 2022-04-04
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: The aim of this study is to, using fMRI, compare brain activations during olfactory imagery induced by different visual supports (words, pictures, colors and colored arrangements) in healthy subjects.

This will allow us to choose the best olfactory imagery facilitator and to assess its effect on cybersickness.


Eligibility criteria: Inclusion Criteria:

* to be of French nationality who has always lived in metropolitan France;
* to be right-handed person;
* to be enrolled in a social security plan;
* to be able to understand the instructions given;
* to have underwent a pre-inclusion medical examination;
* to give a written consent;
* Person with a strong capacity for olfactory imagination: having obtained a score strictly below 2.5 on the fVOIQ olfactory imagination questionnaire.

Exclusion Criteria:

* to have an inability to read French;
* to be recognized as a synesthete;
* to have a professional activity requires intense olfactory activity;
* to have a partial or total loss of smell (hyposmia, anosmia);
* to have qualitative smell disorders (carcosomia, hyperosmia, phantosmia, parosmia);
* to have smell disorders of neurological, post-traumatic or neurodegenerative origin;
* to have uncorrected or poorly corrected visual disturbances;
* to have vestibular disorder diagnosed;
* any contraindication to MR examination (active medical device, ferromagnetic foreign body, pregnancy, morbid obesity, claustrophobia, ... );
* subject under a measure of legal protection.

Primary outcomes:
measure: Comparison of cerebral activations between the different supports mediating the olfactory imagination during the execution of the fMRI tasks.
timeFrame: Baseline (J0)
Secondary outcomes:
measure: Determination of the visual support allowing the strongest olfactory imagination during the fMRI by subjective evaluations using two 4-level Likert scales.
timeFrame: Baseline (J0)
measure: Determination of the visual support allowing the strongest olfactory imagination during the fMRI test by the cerebral activations in areas recognized for their implications in the olfactory imagination.
timeFrame: Baseline (J0)
measure: Description of the evolution of the cardiac activity during olfactory imagination tasks in fMRI.
timeFrame: Baseline (J0)
measure: Description of the evolution of the respiratory activity during olfactory imagination tasks in fMRI.
timeFrame: Baseline (J0)
measure: Evaluation of the state of discomfort in virtual reality by measuring the cardiac activity.
timeFrame: Baseline (J0) and 6 months maximum after J0 (V1)
measure: Evaluation of the state of discomfort in virtual reality by the "Simulator Sickness Questionnaire" (SSQ) before and after immersion.
timeFrame: Baseline (J0) and 6 months maximum after J0 (V1)
Other outcomes:
Locations:
city: Nancy
country: France
facility: CHRU Nancy
Study officials:
References:
citation: Fantin L, Ceyte H, Ramdane-Cherif Z, Jacquot M, Hossu G. French Vividness of Olfactory Imagery Questionnaire: A Potential Tool for Diagnosing Olfactory Loss by Assessing Olfactory Imagery? Front Psychol. 2020 Dec 21;11:606667. doi: 10.3389/fpsyg.2020.606667. eCollection 2020.