Clinical trial NCT06320288: Analysis of Trunk and Center of Mass Control Development During Gait in Children With Cerebral Palsy (VERTEBRAL)
Official title: Analysis of Trunk and Center of Mass Control Development During Gait in Children With Cerebral Palsy
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Children With Cerebral Palsy
Lead sponsor: Union de Gestion des Etablissements des Caisses d'Assurance Maladie - Nord Est
Sponsor class: OTHER
First posted: 2024-03-20
Enrollment: 270
Sex: ALL
Minimum age (years): 18
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Children with cerebral palsy presenting gait pattern disorders receive consultation and/or care (day or full hospitalization) at the Flavigny-sur-Moselle CMPRE.

Brief summary: During the acquisition of posturokinetic abilities such as walking, postural control of the trunk is of paramount importance. Indeed, its development is strongly linked to the overall motor function of children. In cerebral palsy (CP), a term that refers to a set of motor disorders following a perinatal lesion, deficits in axial control are present from early childhood. These deficits are strongly correlated with the functional deficits observed in this population. In particular, during walking, deviations of the trunk (amplitudes, accelerations) are observed in the three planes of space. While recent literature increasingly questions the impact of trunk control deficit on the walking of children with CP, elements are still missing for a holistic understanding of the interaction between locomotor and postural disorders in children with CP. In particular, no study has focused on the deviations of trunk control and the center of mass (which is a global indicator of balance strategies) during the development and maturation of walking in children with CP. Therefore, the primary objective of this cross-sectional observational study will be to characterize the development of trunk control and center of mass during walking in children with CP.


Eligibility criteria: Inclusion Criteria:

* Children (\< 18 years) with cerebral palsy
* GMFCS I to III
* Independent walking with or without technical walking aids (walker, crutches, etc.)
* Able to understand the instructions of various clinical assessments and functional explorations
* Affiliated with a social security scheme

Exclusion Criteria:

Children with cerebral palsy

* Neuro-orthopaedic surgery of the lower limbs or trunk within the last 12 months
* Botulinum toxin A injections within the last 6 months
* Therapeutic intervention targeting trunk control last 6 months

Typically developing children

* Surgery on lower limbs or trunk last 12 months
* Neurological and/or orthopedic pathology that may influence gait

Primary outcomes:
measure: Trunk and center-of-mass accelerations and acceleration variability
timeFrame: At the end of the one-day experimental
Secondary outcomes:
measure: Gait Variability Index
timeFrame: At the beginning of the one-day experimental
measure: Trunk Control Measurement Scale score (TCMS)
timeFrame: At the beginning of the one-day experimental
measure: Early Clinical Assessment of Balance score
timeFrame: At the beginning of the one-day experimental
Other outcomes:
Locations:
city: Nancy
country: France
facility: Institut Régional de Médecine Physique et de Réadaptation
Study officials:
References: