louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03324893: FCH PET/MRI Parathyroid Localization
Official title: 18F-Fluorocholine PET/MRI for the Localization of Parathyroid Adenomas
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: 18F-fluorocholine
Positron-Emission Tomography
Hyperparathyroidism, Primary
Lead sponsor: University Health Network, Toronto
Sponsor class: OTHER
First posted: 2017-10-30
Enrollment: 47
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: A prospective trial comparing the accuracy of \[F-18\]-FCH PET/MRI to US and 99mTc-MIBI SPECT/CT for pre-operative parathyroid localization in patients with primary hyperparathyroidism


Eligibility criteria: Inclusion Criteria:

* Age ≥ 18 years
* Biochemically proven primary hyperparathyroidism
* Indication for parathyroidectomy as per institutional guidelines

Exclusion Criteria:

* Contraindication for MRI as per current institutional guidelines.
* Contraindication for Gadolinium injection as per current institutional guidelines.
* Renal failure
* Inability to lie supine for at least 45 minutes.
* Any participant who is pregnant or breastfeeding.
* Participants receiving erythropoietin (i.e. for hemochromatosis; might lead to false negative results due to stimulation of bone marrow metabolism)
* Familial HPT syndromes
* Participant currently being treated with any cytotoxic chemotherapy

Primary outcomes:
measure: Accuracy of [F-18]-FCH PET/MRI in localization of diseased parathyroid gland
timeFrame: 1 month postoperatively
Secondary outcomes:
Other outcomes:
Locations:
city: Toronto
country: Canada
facility: UHN
state: Ont
Study officials:
References:
Clinical trial NCT00928993: An Evaluation of Actigraphy as an Indicator of Sleep and Wake in Children
Official title: An Evaluation of Actigraphy as an Indicator of Sleep and Wake in Children
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Sleep Monitoring
Keywords: actigraphy
polysomnography
pediatrics
sleep
To validate Actigraphy against polysomnography
Lead sponsor: Oregon Health and Science University
Sponsor class: OTHER
Collaborators: name: Philips Respironics
First posted: 2009-06-26
Enrollment: 48
Sex: ALL
Minimum age (years): 6
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: pediatric patients receiving sleep study as part of their standard medical care

Brief summary: The purpose of this study is to learn how well an instrument called an Actiwatch-2 can determine whether a child is asleep or awake. The Actiwatch-2 (manufactured by Minimitter/Respironics of Bend, Oregon) is the brand name for an actigraphy monitor; that is, a motion sensor that is typically worn on the wrist and looks like a wrist watch. It measures and records the amount of movement a person makes each minute. After being worn overnight, data are transferred from the Actiwatch to a computer, and a program estimates whether a person is awake or asleep by analyzing the recorded movement data. The enrollment target is 80 participants. Although other actigraphy equipment has been used to monitor sleep in children, the Actiwatch-2 has not been validated in the pediatric population.


Eligibility criteria: Inclusion Criteria:

* Children (ages 6 months to 18 years) who are undergoing a medically necessary sleep study \[polysomnography (PSG)\] in the OHSU Sleep Disorders Laboratory
* ASA classification I and II (children in good health)

Exclusion Criteria:

* ASA classification III, IV (children with a chronic or severe disease).
* Children with developmental delay.
* Children born extremely prematurely (before 32 weeks gestation), as these children and their parents may react differently to experimental procedures
* Children who do not speak English or whose parents do not speak English.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Portland
country: United States
facility: Multnomah Pavilion, OHSU
state: Oregon
Study officials:
affiliation: Oregon Health and Science University
name: Kyle Johnson, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01393093: Transcatheter Arterial Chemoembolization With KMG Microsphere Treating Advance-stage Hepatocellular Carinomas
Official title: Clinical Trial of Transcatheter Arterial Chemoembolization With KMG Microsphere Treating Advance-stage Hepatocellular Carinomas
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Carcinoma, Hepatocellular
Keywords: HCC
TACE
Lead sponsor: Tianjin Medical University Cancer Institute and Hospital
Sponsor class: OTHER
First posted: 2011-07-13
Enrollment: 2840
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: TREATMENT

Brief summary: The purpose of the study is to evaluate the effects of Transcatheter Arterial Chemoembolization (TACE) with KMG microsphere in treating advance-stage Hepatocellular Carinoma(HCC).

Detailed description: This is a prospective, multicentre, random, controlled clinical trial of Transcatheter Arterial Chemoembolization (TACE)with KMG Microsphere Treating Advance-stage Hepatocellular Carinomas.

Eligibility criteria: Inclusion Criteria:

1. Hepatocellular Carinomas with diagnosis of pathology or cytology or consistent with China 2001 guideline of Clinical Diagnosis Hepatocellular Carinomas
2. clinical stage（The Barcelona Liver Clinic staging system,BCLC B and C)，or can not receive surgical intervention
3. liver function:Child-Pugh A、B
4. PST 0-1（Eastern Cooperative Oncology Group Performance Score ,ECOG）
5. Lifespan≥6 months
6. First time to receive treatment
7. Can accept the follow up
8. informed consent was gotten
9. the number of lesion ≤ 5

Exclusion Criteria:

1. pregnant or lactation woman
2. emotional disturbance
3. serious heart ,lung disfunction or serious diabetes mellitus
4. serious reactiveness infections;（exp:type B or C hepatitis）
5. liver function :Child-Pugh Score C
6. thrombocyte\<6×109/L
7. diffuse HCC
8. widespread metastasis
9. serious atherosclerosis
10. acquired immunodeficiency syndrome;AIDS
11. thrombosis or thrombosis event in 6 months
12. renal inadequacy who need hemodialysis or peritoneal dialysis
13. with other tumors except basal cell carcinoma and carcinoma in situ of cervix
14. serious alimentary tract hemorrhage in 4 weeks

Primary outcomes:
measure: Time to progression
timeFrame: 3 years
Secondary outcomes:
measure: total survival
timeFrame: 3 year
measure: remission rate
timeFrame: 3 years
Other outcomes:
Locations:
city: Tianjin
country: China
facility: Tianjin Medical University Cancer Hospital
state: Tianjin
Study officials:
affiliation: Tianjin Medical University Cancer Hospital
name: Zhi Guo, MD
role: STUDY_CHAIR
References:
Clinical trial NCT01023893: Blood Viscosity, End-Stage Renal Disease, And Mortality (BEAM-1)
Official title: Clinical Diagnostic Evaluation Study of Blood Viscosity, End-Stage Renal Disease, And Mortality
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Renal Replacement Therapy
Lead sponsor: ProMetrics, Inc.
Sponsor class: INDUSTRY
First posted: 2009-12-02
Enrollment: 400
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Dialysis clinic

Brief summary: Prospective, real-time observational study of hemodialysis patients treated with erythropoiesis-stimulating agents (ESA) to currently recommended Hgb targets. Subjects will be evaluated dynamically for their blood viscosity status at the beginning and end of the dialysis treatment, and followed prospectively to assess outcomes. Blood specimens will be collected via the subject's hemodialysis port pre- and post-hemodialysis per study assessment visit. Blood will be analyzed at a designated laboratory facility for viscosity over a comprehensive range of shear rates and tested for intradialytic surges in blood viscosity. Subjects will be followed for 48 weeks.


Eligibility criteria: Inclusion Criteria:

* Age \> 18 years old
* On hemodialysis \> 3 months
* On ESA treatment \> 3 months
* Mean Hgb 11 g/dL - 12 g/dL (based on at least 3 Hgb results during the previous 8 weeks)
* Latest Hgb 10.5 g/dL - 12.5 g/dL (measured within 1 week of study)

Exclusion Criteria:

* Inability or unwillingness to provide informed consent
* Large variability in interdialytic weight gain (\>2 kg difference between low and high weight gain over last month)
* More than 1 missed dialysis treatments in past month
* Recent bleeding
* Blood transfusion within 1 month
* Hematologic disease other than anemia
* Active inflammatory disease
* Active infection

Primary outcomes:
measure: Cardiovascular mortality
timeFrame: One year
Secondary outcomes:
measure: All-cause mortality
timeFrame: One year
measure: Vascular access thrombosis
timeFrame: One year
Other outcomes:
Locations:
Study officials:
References:
citation: Vaisman S, Kensey K, Cho YI. Effect of hemodialysis on whole blood viscosity. Int J Artif Organs. 2009 Jun;32(6):329-35. doi: 10.1177/039139880903200603.
citation: Lowe GD, Lee AJ, Rumley A, Price JF, Fowkes FG. Blood viscosity and risk of cardiovascular events: the Edinburgh Artery Study. Br J Haematol. 1997 Jan;96(1):168-73. doi: 10.1046/j.1365-2141.1997.8532481.x.
Clinical trial NCT02581293: Effect of Visceral and Parietal Peritoneum Suturation on Postoperative Vital Signs
Official title: Effect of Visceral and Parietal Peritoneum Suturation on Postoperative Vital Signs
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
Conditions: Postoperative Pain
Lead sponsor: Zeynep Kamil Maternity and Pediatric Research and Training Hospital
Sponsor class: OTHER
First posted: 2015-10-20
Enrollment: 132
Sex: FEMALE
Maximum age (years): 40
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: SCREENING

Brief summary: In this study the investigators want to asses the effect of peritonisation at c-section on postoperative vital signs which was thought to be an indirect finding secondary to increased sympathetic activity originated from pain caused by stretched peritoneum.

Detailed description: At c-section subject will be randomised into four groups:

Group1: Only visceral peritoneum will be closed

Group 2: Only parietal peritoneum will be closed

Group 3: Both of them will be closed

Group 4: None of them will be closed

During the postoperative period all patients will undergo vital sign screening including urine output, blood pressure measurement, pulse rate and VAS score will be determined at post operative 6th hour and 24th hour.

Eligibility criteria: Inclusion Criteria:

* Women underwent uncomplicated c-section

Exclusion Criteria:

* Patient with systemic Diseases
* Pregnant with Obstetric complications
* Pregnant with two or more previous c-sections

Primary outcomes:
measure: Postoperative vital sign (arterial tension)
timeFrame: First postoperative hour
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Meryem Kurek EKEN
state: Üsküdar
Study officials:
affiliation: Zeynep Kamil Education and Research Hospital Obstetric and Gynecology Department
name: Enis Özkaya, Assoc. Prof.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06695793: Niche Investigated: Closure of Hysterotomy & Evaluation of 3 Suturing Techniques (Running, Interrupted, and Locked)
Official title: Niche Investigated: Closure of Hysterotomy & Evaluation of 3 Suturing Techniques (Running, Interrupted, and Locked)
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Caesarean Scar Niche
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2024-11-19
Enrollment: 225
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: This study aims to explore the impact of three different suturing techniques (Running, Interrupted \& Locked) that used to close the uterine incision at the cesarean section on the formation of a cesarean scar niche


Eligibility criteria: Inclusion Criteria:

1. Women with a singleton pregnancy scheduled for elective cesarean section
2. Gestational age at the time of cesarean section between 38 and 40 weeks.
3. Willingness to participate in the study and provide informed consent
4. Age between 18 and 35 years old.
5. BMI \<30

Exclusion Criteria:

1. Known uterine anomalies or previous uterine surgery (e.g, myomectomy, uterine septum resection)
2. Pre-existing medical conditions contraindicating cesarean delivery or affecting uterine healing (e.g., Anemia, Diabetes)
3. Current smokers.
4. Non-cephalic presentation of the fetus.
5. Low-lying anterior wall placenta and placenta previa.
6. Inability to provide informed consent (e.g., cognitive impairment, language barrier)
7. Any condition deemed by the attending physician to pose a risk to the participant or compromise the study's integrity, for example, Patients who will require excessive suturing for further hemostasis or those who require ligation of one or both uterine arteries

Primary outcomes:
measure: Presence of caesarean scar niche and its dimensions.
timeFrame: 6-12 weeks post-cesarean section
Secondary outcomes:
measure: Operative time
timeFrame: during operation
measure: Estimate blood loss
timeFrame: during operation
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Cairo University
city: Cairo
country: Egypt
facility: Cairo University
city: Cairo
country: Egypt
facility: Cairo University
city: Cairo
country: Egypt
facility: Cairo University
city: Cairo
country: Egypt
facility: Cairo University
Study officials:
References:
Clinical trial NCT05993793: Use of Fototherapy in the Treatment of Fissure in Ano
Official title: Use of Fototherapy in the Treatment of Fissura in Ano
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Fissure in Ano
Keywords: fissure
ano
phototherapy
Lead sponsor: Centro de Atenção ao Assoalho Pélvico
Sponsor class: OTHER
First posted: 2023-08-15
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SEQUENTIAL
Primary purpose: TREATMENT

Brief summary: The eligible population consisted of individuals with anal fissure awaiting surgical intervention. Individuals aged 18 years or older were included, diagnosed with anal fissure and who voluntarily agreed to participate in the research. Those who had some pelvic inflammation and who had already undergone a surgical procedure and had recurrence were excluded from the studyThe selected individuals underwent a standardized anamnesis of the service, answered questionnaires on symptoms of intestinal constipation (Rome IV Criteria and the Bristol Scale), underwent a physical evaluation by a trained professional, and then began the application of the research protocol. The Antares brand Laser device was used for 3 sessions with an interval of 24 hours. The Visual Analogue Scale (VAS) was used before starting treatment, after the first and second sessions, and 1 week after the third session. In addition, at the end of the treatment, the closure, or not, of the lesion was verified, and the questionnaires performed prior to phototherapy were reapplied. The VAS assesses the patient's level of pain, which can be divided into mild pain (1-2), moderate pain (3-7), and severe pain (8-10). The Bristol Scale is based on the identification of the patient's consistency of stools, while types 1-2 correspond to constipation, 3-4 indicate normal intestinal rhythm, 5 indicate lack of fiber, and 6-7 correspond to diarrhea.


Eligibility criteria: Inclusion Criteria:

* individuals with the diagnosis of anal fissure that accepted to participate as volunteers in the clinical trial

Exclusion Criteria:

* individuals with pelvic inflammation
* individuals who have been through surgical procedures
* individuals who have relapse

Primary outcomes:
measure: Complete closure of the fissure
timeFrame: 15 days
Secondary outcomes:
Other outcomes:
Locations:
city: Salvador
country: Brazil
facility: Instituto Patrícia Lordelo
state: BA
Study officials:
References:
Clinical trial NCT01274793: Trial for Quantity-Effect Relationship of Acupuncture With Two-ways Regulation to Treat Functional Enteropathy
Official title: Multicentre Randomized Controlled Trial for Quantity-Effect Relationship of Acupuncture With Two-ways Regulation to Treat Functional Enteropathy
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
Conditions: Functional Constipation
Functional Diarrhea
Keywords: functional constipation
functional diarrhea
acupuncture
Lead sponsor: Huazhong University of Science and Technology
Sponsor class: OTHER
Collaborators: name: The Fifth Hospital of Wuhan
name: Wuhan Union Hospital, China
name: Guangzhou University of Traditional Chinese Medicine
First posted: 2011-01-12
Enrollment: 240
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: the objective of this study is to investigate the Dose-Effect Relationship of Acupuncture with Two-ways Regulation Effect to Treat Functional Enteropathy

Detailed description: eligibility criteria: functional constipation,functional diarrhea，irritable bowel syndrome

Eligibility criteria: Inclusion Criteria:

* function constipation function diarrhea

Exclusion Criteria:

* not function constipation not function diarrhea

Primary outcomes:
measure: acupuncture benefits functional constipation
timeFrame: 5 years
Secondary outcomes:
Other outcomes:
Locations:
city: Wuhan
country: China
facility: Institute of Integrated Traditional Chinese and Western Medicine, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
state: Hubei
Study officials:
affiliation: institute of integrated traditional chinese and western medicine，Tongji meidical college,HUST
name: Guangying Huang, doctor
role: STUDY_DIRECTOR
References:
citation: Xu X, Zhang M, Wu X, Zheng C, Huang G. The Effect of Electroacupuncture Treatment with Different Intensities for Functional Diarrhea: A Randomized Controlled Trial. Evid Based Complement Alternat Med. 2022 Jan 4;2022:2564979. doi: 10.1155/2022/2564979. eCollection 2022.
citation: Zheng CH, Huang GY, Xu XH, Wang Y, Zhang MM, Wang W, Jing XH, Zhu B. Electro-acupuncture with different current intensities to treat functional constipation: a study protocol for a randomized controlled trial. Trials. 2013 Oct 22;14:344. doi: 10.1186/1745-6215-14-344.
Clinical trial NCT03064711: Activity and Fatigue of the Respiratory Muscles and Pulmonary Characteristics in Post-Polio Patients
Official title: Comparison of Activity and Fatigue of the Respiratory Muscles and Pulmonary Characteristics Between Post-Polio Patients and Healthy Controls: A Pilot Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Post-polio Syndrome
Lead sponsor: Hadassah Medical Organization
Sponsor class: OTHER
First posted: 2017-02-27
Enrollment: 24
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: Background: Early diagnosis of respiratory impairment in Post-Polio (PPS) patients may delay respiratory decline and future need of invasive respiratory aids.

Objectives: To compare pulmonary function measures, maximal respiratory pressure and activity levels and fatigue of respiratory muscles between patients with PPS and healthy controls.

Design: Cross-sectional study. Setting: Hadassah physical medicine and rehabilitation department, Jerusalem. Patients: Patients with PPS (N=12; 6 males; age 62.1±11.6 years) able to walk for 6 minutes without human assistance; age-matched healthy subjects (N=12; 4 males; age 62.2±6.5 years).

Intervention: None. Measurements: A body plethysmograph was used to quantify forced expiratory volume in the first second of a forced expiratory maneuver, vital capacity, slow vital capacity, Residual Volume (RV), Total Lung Capacity (TLC), and Thoracic Gas Volume (TGV). Also, RV to TLC ratio is calculated. A manometer was used to measure Maximal Inspiratory Pressure (MIP) and Maximal Expiratory Pressure (MEP). A spirometer was used to measure Maximal Voluntary Ventilation (MVV). Surface electromyography (sEMG) recorded diaphragmatic muscle activity during rest and while performing MVV.


Eligibility criteria: Inclusion Criteria:

* Diagnosed with post-polio syndrome
* Able to walk for 6 minutes, with or without walking aids and orthotics but without human assistance

Exclusion Criteria:

* Any neurological or orthopedic condition, unrelated to post-polio syndrome

Primary outcomes:
measure: Median frequency of electromyography
timeFrame: Two hours
Secondary outcomes:
measure: Pulmonary function
timeFrame: Two hours
measure: maximal inspiratory/expiratory pressures
timeFrame: Two hours
Other outcomes:
Locations:
city: Jerusalem
country: Israel
facility: Hadassah Medical Center
Study officials:
References: