louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02615236: Prospective Evaluation of Perineal Ultrasound in Thr Delivery Room to Improve the Diagnosis of OASIS
Official title: Prospective Evaluation of Perineal Ultrasound in Thr Delivery Room to Improve the Diagnosis of OASIS
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Episiotomy
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2015-11-26
Enrollment: 300
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: The aim of the study is to evaluate the role of routine perineal scan using 2D ultrasound immediatly after delivery to diagnose hidden perineal trauma that might affect patient's fecal continance

Detailed description: In countries where there is high prevalence of doing episiotomy in primiparous women, the incidence of sustained obstetric anal sphincter injuries is increasing.

When the tear extend beyond the external anal sphincter its called 'OASIS' that might lead to either immediate of delayed anal incontinence. Anal incontinence is associated with significant medical, hygiene and social problems. Use of perineal ultrasound as a bedside test immediately after vaginal delivery could improve the diagnosis and determining the degree of these perineal traumas. This increased detection could lead to improved primary repair of the external and internal anal sphincter resulting in reduced rates of anal incontinence and improved quality of life for women

Eligibility criteria: Inclusion Criteria:

* primiparous women immediately after vaginal delivery

Exclusion Criteria:

* history of anal incontinence
* previous anal sphincteric injuries
* previous anal surgery

Primary outcomes:
measure: anal incontinence
timeFrame: 3 months after delivery
Secondary outcomes:
measure: pain score
timeFrame: 3 and 12 month after delivery
measure: questionnaire for effect on quality of life
timeFrame: 3 and 12 month after delivery
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty of Medicine, Ain Shams University
state: Al Qahirah
Study officials:
affiliation: Ain Shams University
name: Ahmed kotb, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03618836: Study of the Risk of PREMaturité According to the Balance of Bacterial Flora VAginale
Official title: Study of the Risk of PREMaturité According to the Balance of Bacterial Flora VAginale (PREMEVA2)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Preterm Birth
Keywords: Bacterial vaginosis
Vaginal microbiota
Molecular methods
Next generation sequencing
Lead sponsor: University Hospital, Lille
Sponsor class: OTHER
Collaborators: name: Ministry of Health, France
First posted: 2018-08-07
Enrollment: 1000
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Cohort of pregnant patients in the first trimester

Brief summary: Objective

To compare vaginal microbiota in the first trimester of pregnancy between spontaneous preterm and term deliveries

Detailed description: Material and methods Case-control study nested in a cohort of pregnant patients in the first trimester. Inclusion criteria. : case is defined as spontaneous preterm births between 22 and 36 weeks in one of the 14 centers. The "control" patient will be considered as the following delivery over ≥ 37 weeks in the same center.

Multiple pregnancies, medical interruptions of pregnancy and deaths in utero will be excluded. Regarding the vaginal flora of cases and controls, the microorganisms will be researched and quantified by molecular methods.

Expected results

Patients and control patients will be compared for their demographic, obstetric, clinical and microbiological data. The parameters related to the risk of spontaneous prematurity at the p \<0.20 threshold will then be analyzed by multi-level logistic regression.

Implications At a time when the link between bacterial vaginosis and prematurity is controversial, the detection - or not - of microorganisms linked to the risk of prematurity will be a key issue.

Eligibility criteria: Inclusion Criteria:

* case: spontaneous preterm births between 22 and 36 weeks in one of the 14 centers
* controls : the following delivery over ≥ 37 weeks in the same center

Exclusion Criteria:

* Multiple pregnancies, medical interruptions of pregnancy and deaths in utero

Primary outcomes:
measure: Vaginal Microbiota pattern
timeFrame: 10 years
Secondary outcomes:
measure: Vaginal biological pattern
timeFrame: 10 years
Other outcomes:
Locations:
city: Lille
country: France
facility: Hôpital Jeanne de Flandres, CHRU
Study officials:
affiliation: University Hospital, Lille
name: Damien Subtil, MD,PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00357136: Online Survey on Computer Password Usage.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Lead sponsor: Towson University
Sponsor class: OTHER
First posted: 2006-07-27
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: RETROSPECTIVE

Brief summary: Researchers at Towson University are conducting a study of computer password behaviors among users who have difficulty using their hands and arms (e.g., individuals with carpal tunnel syndrome, high level spinal cord injuries, etc.). Volunteers are needed to take a short 5-10 minute online survey.

The survey is completely confidential and anonymous. If you would like to participate, please visit the URL below. Thank you.

http://pages.towson.edu/jdarcy/securitysurvey.htm

Detailed description: Two researchers from the Department of Computer \& Information Sciences at Towson University are seeking individuals who have difficulty using their hands and arms (e.g., as result of carpal tunnel syndrome, high level spinal cord injuries, etc.) to participate in a survey. The survey should take approximately 10 minutes to complete and all responses will remain completely confidential and anonymous.

The purpose of the survey is to gain insight into the computing behaviors of individuals with upper-body motor impairments. We expect that the results will help researchers and system developers create more effective access control techniques to meet the special needs of this user population. The results should also assist employers in providing improved technical and procedural support to computer users that have difficulties using standard input devices.

If you would like to take the online survey, please go to the following link:

http://www.towson.edu/cosc/securitysurvey

If you prefer a paper version of the survey, please send us an e-mail that contains your mailing address and we will send the survey to you.

Contact information:

John D'Arcy, Ph.D. (jdarcy@towson.edu) Jinjuan Feng, Ph.D. (jfeng@towson.edu) Department of Computer \& Information Sciences Towson University 7800 York Road Towson, MD 21252 U.S.A.

Eligibility criteria: Inclusion Criteria:

* Users who have difficulty using their hands or arms

Exclusion Criteria:

-

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Towson
country: United States
facility: Towson University
state: Maryland
Study officials:
affiliation: Towson University
name: Jinjuan Feng, Ph. D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00173836: Swallowing Pattern of Patients With Nasopharyngeal Cancer Before and After Radiation Therapy: Longitudinal Study and Correction With Saliva Amount
Official title: Swallowing Pattern of Patients With Nasopharyngeal Cancer Before and After Radiation Therapy: Longitudinal Study and Correction With Saliva Amount
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Nasopharyngeal Carcinoma
Keywords: Nasopharyngeal carcinoma
Saliva
Swallowing
Videofluoroscopy
Radiation
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2005-09-15
Enrollment: 122
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Nasopharyngeal cancer patients

Brief summary: Significant evidence has shown that radiation therapy for patients with nasopharyngeal cancer (NPC) can cause swallowing abnormality. Based on our prior cross-sectional study for 184 NPC patients from 1995 to 1999, the findings of videofluoroscopic swallowing study (VFSS) revealed continuous deterioration of swallowing function of these patients even many years after radiation. We conducted a prospective study to evaluate the longitudinal change of swallowing function based on VFSS before, one month, one year and two years after completing radiation therapy. The amount of saliva was measured at the same time of VFSS study to test the relationship of decreased amount of saliva and swallowing function. Comparison of serial VFSS studies in NPC patients (n=84) and normal volunteers (n=38) were obtained. We assume that this study may reveal a complete understanding of changing swallowing patterns in the course of radiation therapy of patients with NPC. From this study, NPC patients can understand their own swallowing function. Therefore, the information may enable for earlier intervention of swallowing training or correction to avoid morbidity of radiation therapy in this patient group.


Eligibility criteria: Inclusion Criteria:

Nasopharyngeal cancer patients \> 20 yrs.

Exclusion Criteria:

pregnant women

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: X-ray fluoroscopy
Study officials:
affiliation: National Taiwan Univserity Hospital and College of Medicine
name: Yeun-Chung Chang, M.D., Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Chang YC, Chen SY, Lui LT, Wang TG, Wang TC, Hsiao TY, Li YW, Lien IN. Dysphagia in patients with nasopharyngeal cancer after radiation therapy: a videofluoroscopic swallowing study. Dysphagia. 2003 Spring;18(2):135-43. doi: 10.1007/s00455-002-0096-x.
Clinical trial NCT04618913: Anticoagulation in Patients With Venous Thromboembolism and Cancer
Official title: VICTORIE (VTE In Cancer - Treatment, Outcomes and Resource Use In Europe)
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Neoplasms
Embolism
Keywords: Venous thromboembolism
Eliquis
Neoplasms
Anti-Coagulation
Lead sponsor: Pfizer
Sponsor class: INDUSTRY
First posted: 2020-11-06
Enrollment: 1
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult patients with a diagnosis of (VTE) venous thromboembolism and active cancer, or a history of cancer, being treated with anticoagulation.

Brief summary: This study is a retrospective analysis of observational cohorts using data from prospectively collected administrative/claims data to investigate treatment patterns,healthcare resource utilisation (HCRU), direct and indirect costs (where feasible), and safety and effectiveness outcomes in patients with VTE and active cancer or patients with VTE and history of cancer who initiate anticoagulant treatment with a VKA, LMWH or NOACs.


Eligibility criteria: Inclusion Criteria:

* A VTE diagnosis
* Active cancer or history of cancer
* Treatment with VKA, NOAC (apixaban, rivaroxaban, dabigatran, edoxaban) or LMWH
* Age ≥ 18 years at the date of index VTE (Venous thromboembolic)

Exclusion Criteria:

* Prior VTE diagnosis
* Diagnosis of prior atrial fibrillation
* Inferior Vena Cava (IVC) filter
* Prior exposure to (OAC) oral anticoagulation or (PAC)parenteral anticoagulation - note: Prophylactic use of (OAC)/(PAC) allowed.
* Pregnancy
* More than one (OAC) oral anticoagulation or (PAC) parenteral anticoagulation dispensed on the index date.
* Patients with less than one day of follow up

Primary outcomes:
measure: Recurrence of Thromboembolism
timeFrame: 6 Months after treatment began as early as 1/1/2013
Secondary outcomes:
Other outcomes:
Locations:
city: London
country: United Kingdom
facility: Pfizer Investigational Site
Study officials:
affiliation: Pfizer
name: Pfizer CT.gov Call Center
role: STUDY_DIRECTOR
References:
Clinical trial NCT03881813: Effectiveness of Two Types of Fixed Lingual Retainers in Preventing Mandibular Incisor Relapse
Official title: Effectiveness of Two Types of Fixed Lingual Retainers in Preventing Mandibular Incisor Relapse
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Relapse
Keywords: fixed retainers
alignment
Lead sponsor: Dow University of Health Sciences
Sponsor class: OTHER
First posted: 2019-03-20
Enrollment: 54
Sex: ALL
Minimum age (years): 14
Maximum age (years): 30
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The study evaluates effectiveness of two types of fixed retainers in post orthodontic patients. Half of the subjects are randomly allocated Group 1 retainer (FRC) and other half is given Group 2 retainer (MSW) and followed for a period of one year.

Detailed description: 54 subjects were recruited and divided into two groups by random allocation. Consents were obtained . Group 1 received fiber reinforced composite retainer and group 2 received multistranded stainless steel wire retainer. The patients were recalled at every three months interval for a period of 12 months. They were evaluated for number of fractures, failure pattern based on adhesive remnant index and relapse tendency by measuring little's irregularity index.

Eligibility criteria: Inclusion Criteria:

* Subjects who have completed fixed appliance orthodontic treatment.
* Subjects who have signed the consent forms.
* Subjects who have accepted the terms and conditions of visiting after every three months for one year.
* Non extraction cases in the mandibular arch with no IPR.
* Patients without caries/ restoration/ fracture on the lower anterior teeth.
* Patients with healthy periodontium with no periodontal disease at that time.

Exclusion Criteria:

* Presence of syndrome or systemic disease.
* Patients taking medications/ drugs.
* Patients with poor oral hygiene.
* Patients with congenitally absent/ missing anterior teeth in the mandibular arch.
* Patients with habit of clenching/ bruxism.
* Patients with history of betel nut chewing.
* Presence of occlusal interferences.

Primary outcomes:
measure: Relapse tendency
timeFrame: 12 months
Secondary outcomes:
measure: Bond failure
timeFrame: 12 months
measure: Failure Pattern
timeFrame: 12 months
Other outcomes:
Locations:
city: Karachi
country: Pakistan
facility: Dow University Of Health Sciences
Study officials:
affiliation: DUHS
name: Nasreen Nagani, BDS
role: PRINCIPAL_INVESTIGATOR
References:
citation: Nagani NI, Ahmed I, Tanveer F, Khursheed HM, Farooqui WA. "Clinical comparison of bond failure rate between two types of mandibular canine-canine bonded orthodontic retainers- a randomized clinical trial". BMC Oral Health. 2020 Jun 29;20(1):180. doi: 10.1186/s12903-020-01167-7.
Clinical trial NCT05902013: Video Laryngoscopy Versus Direct Laryngoscopy for Nasotracheal Intubation
Official title: Video Laryngoscopy Versus Direct Laryngoscopy for Nasotracheal Intubation in Neonates and Infants With Congenital Heart Disease Less Than 1-year of Age Prior Cardiac Surgery: a Pilot Study
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Congenital Heart Disease
Airway Complication of Anesthesia
Keywords: Endotracheal intubation
Lead sponsor: Medical University of Vienna
Sponsor class: OTHER
First posted: 2023-06-13
Enrollment: 180
Sex: ALL
Maximum age (years): 1
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of this study is to perform a pilot study investigating the first attempt intubation success rate differing between video laryngoscope nasotracheal intubation and direct laryngoscope nasotracheal intubation.

The study population will consist of 60 neonates and infants with congenital heart disease less than 1 year of age who need nasotracheal intubation during general anesthesia for cardiac procedures.

Standard nasotracheal intubation will be performed using either a video laryngoscope or direct laryngoscopy. Neonates and infants will be randomly assigned (1:1) to standard video laryngoscopy (with one of the following systems: Storz C-MAC Miller Video Laryngoscope, Karl Storz, Tuttlingen, Germany or Mc Grath Video Laryngoscope, Medtronic, Boulder,USA) or to direct laryngoscopy with one of the following blades: Miller or Macintosh (Heine, Hersching, Germany).


Eligibility criteria: Inclusion criteria.

* Age less than 1 year
* Congenital heart disease
* Scheduled for cardiac surgery
* Planned postoperative ICU stay

Exclusion criteria

* Nostrils not suitable for nasotracheal intubation
* Bleeding during dilation of nostrils

Primary outcomes:
measure: first attempt intubation success rate
timeFrame: study period, 30 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Vienna
country: Austria
facility: Medical University Vienna
Study officials:
affiliation: Medical University of Vienna
name: Eva M Base, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03551613: Effect of Honey Supplementation on Serum Leptin in Malnourished Infants and Children
Official title: Effect of Honey Supplementation on Serum Leptin in Malnourished Infants and Children
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Malnourished Infants and Childern
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2018-06-11
Enrollment: 75
Sex: ALL
Minimum age (years): 6
Maximum age (years): 3
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: This study was a randomized single blinded case control prospective intervention study.

Detailed description: Fifty infants and children of both sexes, aged 6 months to 3 years, with malnutrition were consecutively recruited from the Nutrition Clinic of the Pediatric Hospital, Ain Shams University.

These patients were randomly assigned following a simple randomization procedure (computerized random numbers) to either the honey group (group 1) or the malnourished control group (group 2) with a 1:1 allocation ratio. Each group consisted of 25 patients.

An additional 25 healthy infants and children with the same age range and of both sexes were recruited from the outpatient pediatric clinic of Ain Shams University, Egypt as a healthy control group (group 3).

The inclusion criteria was in whom the under nutrition is caused by inadequate energy intake, while the exclusion criteria included markedly ill patients, and children with chronic or severe systemic illness or malabsorption disorders, chromosomal aberrations, inborn errors of metabolism and cerebral palsy.

History taking with special emphasis on the dietetic history, history of any disease that might interfere with the nutrient intake or their use by the body and history of any acute or chronic illness. And full body Examination which include anthropometric measurements weight, height and mid arm circumference.

Each patient in the intervention group or honey group or group 1 took oral honey in a dose of 2ml/kg/day for 8 weeks; the calculated dose of honey was dissolved in water with a ratio of 1: 3, respectively, and then ingested by the patient before breakfast.

Eligibility criteria: Inclusion Criteria:

simple malnutrition

Exclusion Criteria:

cancer, sepsis, endocrine disorders, neurologic disorders, diabetes mellitus, heart failure renal failure liver cell failure. malabsorption disorders, chromosomal aberrations, inborn errors of metabolism cerebral palsy .

Primary outcomes:
measure: serum leptin
timeFrame: 2 month duration of honey supplementation
measure: anthropometric measurements
timeFrame: 2 month duration of honey supplementation
Secondary outcomes:
measure: frequency of infection and total caloric intake in the honey group
timeFrame: 2 month duration of honey supplementation
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01211613: Chiropractic Manipulation and Medical Care for Low Back Pain
Official title: A Comparison of Chiropractic Manipulation Methods and Standard Medical Care for Low Back Pain
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Low Back Pain
Keywords: Manipulation
Chiropractic
Low Back Pain
Lead sponsor: University of Pittsburgh
Sponsor class: OTHER
Collaborators: name: National Center for Complementary and Integrative Health (NCCIH)
First posted: 2010-09-29
Enrollment: 107
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The investigators will be comparing the effectiveness of two types of chiropractic manipulation and standard medical care for patients with a recent onset of low back pain. The two types of chiropractic treatments being compared will be hands-on (manual) manipulation and mechanical-assisted (Activator) manipulation. The standard medical care will consist of a medical examination and prescription for over-the-counter anti-inflammatory medication.


Eligibility criteria: Inclusion Criteria:

* Age: ≥ 18 years of age
* Ability to read and write English
* Experiencing a new episode of low back pain (LBP) with onset in the past 3 months
* Oswestry Disability Index score between 20-70 points (0-100 scale)
* Numeric pain rating score between 3-8 points (0-10 scale)

Exclusion Criteria:

* Prior history of lumbar spine surgery
* History of unstable spondylolisthesis, spinal stenosis, or scoliosis \> 20°
* Signs or symptoms suggestive of nerve root tension and/or neurological deficit in the lower extremity
* History of metastatic cancer, osteoporosis, long-term corticosteroid use, or any other red flags of serious illness including the following: unexplained weight loss of \>10% of body weight, spinal pain associated with fever, and severe night pain unrelieved by medication
* Receiving any physical therapy, chiropractic therapy, or any other manual therapy for this episode of LBP (within the past 3 months)
* Receiving any on-going medical care for this episode of low back pain
* Current use of opiate or other prescription medications for low back pain

Primary outcomes:
measure: Oswestry Low Back Pain Disability Index
timeFrame: 4 weeks (post treatment)
Secondary outcomes:
measure: Numeric Pain Rating Score.
timeFrame: 4 weeks (post treatment)
Other outcomes:
Locations:
city: Pittsburgh
country: United States
facility: University of Pittsburgh Medical Center: Center for Integrative Medicine
state: Pennsylvania
Study officials:
affiliation: University of Pittsburgh
name: Michael J Schneider, PhD, DC
role: PRINCIPAL_INVESTIGATOR
References:
citation: Schneider MJ, Brach J, Irrgang JJ, Abbott KV, Wisniewski SR, Delitto A. Mechanical vs manual manipulation for low back pain: an observational cohort study. J Manipulative Physiol Ther. 2010 Mar-Apr;33(3):193-200. doi: 10.1016/j.jmpt.2010.01.010.