Clinical trial NCT05866133: Relationship of Addictions to Obesity, Physical Activity and Vascular Ageing in Young Adults
Official title: Relationship of Addictions to Obesity, Physical Activity and Vascular Ageing in Young Adults
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Drug Addiction
Technology Addiction
Young Adult
Keywords: Lifestyles
Vascular ageing
Obesity
Lead sponsor: Fundacion para la Investigacion y Formacion en Ciencias de la Salud
Sponsor class: OTHER
Collaborators: name: Castilla-León Health Service
name: Instituto de Investigación Biomédica de Salamanca
First posted: 2023-05-19
Enrollment: 500
Sex: ALL
Minimum age (years): 18
Maximum age (years): 34
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Urban population assigned to the health area of Salamanca. By means of stratified random sampling by age and sex groups with replacement, based on the individual health card (TIS), subjects aged between 18 and 34 years will be selected.

Brief summary: This is a cross-sectional observational study whose objective is to analyse the relationship between behavioural addictions and drug addictions with obesity, physical activity, sedentary lifestyle, arterial stiffness and vascular ageing in young adults, since many of the lifestyles of adulthood are established early in life, and it is easier to prevent them before they start than to achieve their abandonment once they are established as unhealthy lifestyles

Detailed description: Behavioural addictions. Brief Questionnaire of Pathological Gambling (CBJP), Lie/Bet scale, Compulsive Internet Use Scale (CIUS), Smartphone Dependence and Addiction Scale (EDAS-18), Questionnaire of Experiences Related to Video Games (CERV). Drug addictions: Alcohol, Smoking and Substance Involvement Screening Test (ASSIST V3.0), Drug Abuse Screening Test (DAST-20), Alcohol Use Disorders Identification Test (AUDIT) and Fagerström test. Obesity and body composition: Weight, height, waist circumference, hip circumference and Inbody 230®. Diet: Mediterranean Diet Adherence Questionnaire. Physical activity: International Physical Activity Questionnaire (IPAQ), Actigraph GTX3 accelerometer and Marshall questionnaire. Analysis of vascular structure and function and target organ lesions. Pulse wave analysis (PWA) and femoral carotid pulse wave velocity (VOPcf) (Sphygmocor System). Cardio Ankle Vascular Index (CAVI), ankle-ankle pulse wave (VOPbt) and ankle-ankle index (ABI) (Vasera VS-2000®). Retinal vascular injury (TOPCON TRC NW 200). Cardiac lesion (General electric 5000). Kidney Injury: analytical variables. Brain Injury: Montreal Cognitive Assessment (MoCA). Vascular ageing (VOPcf and VOPbt). Other variables. Basal glycaemia, HbA1c. TSH, lipid profile, creatinine and creatinine albumin index and Vit D. Measurement of blood pressure and drug consumption.

Eligibility criteria: Inclusion Criteria:

* Patients between 18 and 34 years of age who agree to participate in the study and do not meet any exclusion criteria.

Exclusion Criteria:

* Subjects who are terminally ill, who are unable to travel to health centres for the corresponding examinations, and who do not sign informed consent.

Primary outcomes:
measure: Pulse wave velocity
timeFrame: 1 year
Secondary outcomes:
measure: Cardio Ankle Vascular Index (CAVI)
timeFrame: 1 year
measure: Pathological gambling
timeFrame: 1 year
measure: Internet use
timeFrame: 1 year
measure: Compulsive use of mobile phones
timeFrame: 1 year
measure: Videogames use
timeFrame: 1 year
measure: Use or abuse of alcohol, tobacco and illegal drugs
timeFrame: 1 year
measure: Problem drug use
timeFrame: 1 year
measure: Excessive alcohol consumption
timeFrame: 1 year
measure: Nicotine dependence
timeFrame: 1 year
measure: Waist and hip circumference
timeFrame: 1 year
measure: Body composition
timeFrame: 1 year
measure: International Physical Activity Questionnaire (IPAQ)
timeFrame: 1 year
measure: Accelerometer
timeFrame: 1 year
measure: Adherence to the Mediterranean diet
timeFrame: 1 year
measure: Sleep quality and quantity
timeFrame: 1 year
measure: Sleep disruption
timeFrame: 1 year
Other outcomes:
Locations:
city: Salamanca
country: Spain
facility: Primary Care Research Unit of Salamanca
Study officials:
affiliation: Primary Care Research Unit
name: Manuel A Gomez-Marcos, Dr
role: PRINCIPAL_INVESTIGATOR
References: