Clinical trial NCT02876770: Melatonin Supplementation and Performance
Official title: Nocturnal Melatonin Ingestion Ameliorates Short Term Maximal Performances on the Following Day
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: EARLY_PHASE1
Conditions: Motor Activity
Lead sponsor: University of Sfax
Sponsor class: OTHER
First posted: 2016-08-24
Enrollment: 12
Sex: MALE
Minimum age (years): 20
Maximum age (years): 23
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The present study aimed to evaluate the possible effect of nocturnal melatonin ingestion upon short-term performances, on the following morning. Twelve soccer players from a Tunisian squad (22.9 ±1.3 years, 1.80±0.05 m, and 72.0±8.8 kg) were volunteered to perform three testing sessions, with one test session per day. During each session, MEL (5mg) , MEL (8mg) or placebo were ingested, in a randomized order, before nocturnal sleep. The next morning (08:00h), participants performed the following psycho-cognitive and physical tests: Hooper's index, reaction time, vigilance, handgrip strength , squat jump , modified agility test , Wingate anaerobic test (peak power , mean power and fatigue index ). Rating of perceived exertion was recorded immediately after the WanT, and blood lactate measures were taken after 3min of recovery. Blood glucose was measured before and 3 min after the Wingate test.


Eligibility criteria: Inclusion Criteria:

The participants were recruited based on the following criteria: (i) paticipants must be trained at 4-6 days per week for an average of 2 h daily and (ii) they must have at least 8 years of training experience

Exclusion Criteria:

* Subjects were excluded from the study if they present one of the following criteria : heart failure, antioxidant supplementation within 3 months before the study, lower-limb injuries

Primary outcomes:
measure: Hooper's index score
timeFrame: At 07:30 am in the following day of the supplementation
measure: handgrip strength (in Kg)
timeFrame: At 07:30 am in the following day of the supplementation
measure: Blood lactate (µmol/l)
timeFrame: Blood lactate was measured only 3 minutes after physical testing in the following day of the supplementation
measure: reaction time (in secondes)
timeFrame: At 07:30 am in the following day of the supplementation
measure: vigilance score
timeFrame: At 07:30 am in the following day of the supplementation
measure: squat jump (in centimeters)
timeFrame: At 07:30 am in the following day of the supplementation
measure: agility (in secondes)
timeFrame: At 07:30 am in the following day of the supplementation
measure: anaerobic capacity (In watts)
timeFrame: At 07:30 am in the following day of the supplementation
measure: glucose level (µmol/l)
timeFrame: At 07:30 am in the following day of the supplementation (rest condition) and 3 minutes after physical testing in each experimental session
measure: Rating of perceived exertion score
timeFrame: Rating of perceived exertion score was measured 3 minutes after physical testing in the following day of the supplementation
Secondary outcomes:
Other outcomes:
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