Clinical trial NCT02951897: Application of Detecting Circulating Tumor Cells in the Accurate Treatment of Early Stage Lung Adenocarcinoma
Official title: Application of Detecting Circulating Tumor Cells in the Accurate Diagnosis and Treatment of Early Stage Lung Adenocarcinoma
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Lung Adenocarcinoma, Stage I
Diagnoses Diseases
Circulating Tumor Cells
Treatment
Keywords: circulating tumor cells
lung adenocarcinoma
treatment
early diagnosis
Lead sponsor: Third Military Medical University
Sponsor class: OTHER
First posted: 2016-11-01
Enrollment: 120
Sex: ALL
Minimum age (years): 45
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: In 2015-2016, 224,390 cases were newly diagnosed with lung cancer in USA. Of all the cases, 83% are non-small cell lung cancer (NSCLC). Currently, the 5-year survival rate of NSCLC patients is 21%, and more than 25% of early stage NSCLC patients, who have undergone surgical treatment, will have a relapse or progression.

Circulating tumor cells (CTCs), which shed from the primary tumor into the vasculature or lymphatics, can be regarded as a new prognostic factors of metastatic process. Thus far, CTCs-detection technologies can be divided into epithelial cell adhesion molecule (EpCAM)-based detection methods, e.g., the widely used CellSearch® and Adnatest®,and EpCAM-independent detection methods, e.g., ISET® and ScreenCell®. Herein, the investigators used a newly established approach, i.e., CanPatrolTM to detect CTCs in early stage lung Adenocarcinoma cases.

The investigator aim to explore whether CTCs detection prior to surgery can be contributive to the early diagnosis, or may help to predict the prognosis and guide the treatment strategy of early stage lung Adenocarcinoma.


Eligibility criteria: Inclusion Criteria:

* stage I lung adenocarcinoma

Exclusion Criteria:

* cases with any new adjuvant treatment prior to surgery

Primary outcomes:
measure: Disease free survival
timeFrame: From date of diagnosis until the date of first documented progression or date of cancer related death , whichever came first, assessed up to 60 months
Secondary outcomes:
Other outcomes:
Locations:
city: Chongqing
country: China
facility: Daping hospital
Study officials:
References:
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