louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06650683: Impact of Providing Nursing Support on Parental Stress Related to Preoperative Care of a Newborn with Hirschsprung's Disease
Official title: Impact of Providing Nursing Support on Parental Stress Related to Preoperative Care of a Newborn with Hirschsprung's Disease
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Hirschsprung Disease
Lead sponsor: Assistance Publique Hopitaux De Marseille
Sponsor class: OTHER
First posted: 2024-10-21
Enrollment: 20
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SEQUENTIAL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Impact of providing nursing support on parental stress related to preoperative care of a newborn with Hirschsprung's disease


Eligibility criteria: Inclusion Criteria:

* Families (one or two parents) with a newborn or infant under 2 months with confirmed or suspected Hirschsprung disease, for whom nursings are effective and performed 1 to 2 times a day while waiting for surgery.
* With a possible return home before surgery
* With an information leaflet and non-opposition form signed by one or both parent(s) or by the legal representative.

Exclusion Criteria:

* The absence of daily nursings
* Initial ineffectiveness of nursings requiring a digestive stoma
* Failure to return home before surgery
* Refusal of one or both parent(s) or legal representative(s)

Primary outcomes:
measure: Questionnary to evaluate stress on parents
timeFrame: From enrollment to the end of treatment at 6 months
Secondary outcomes:
measure: Auto-Questionnary MIB (Mother Infant Bounding) to evaluate the impact of nursing support
timeFrame: From enrollment to the end of treatment at 6 months
measure: Self-Questionnary Burden inventory to evaluate the nursery training provided
timeFrame: From enrollment to the end of treatment at 6 months
Other outcomes:
Locations:
city: Marseille
country: France
facility: APHM
Study officials:
References:
Clinical trial NCT05830383: Application of PDCA Circular Management to Improve Critical Thinking Skills of ICU Nurses Within Five Years of Employment
Official title: Application of PDCA Circular Management to Improve Critical Thinking Skills of ICU Nurses Within Five Years of Employment
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: PDCA Circular Management
Keywords: PDCA circular management;critical thinking skills
Lead sponsor: Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Sponsor class: OTHER
First posted: 2023-04-26
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: Choose about 100 low -age nurses who have been in the ICU in 2022, and conduct a scoring score of the survey and critical thinking skills through the schedule. Based on the survey and scoring results ,Formulate the PDCA circular management process and conduct a judgment of critical thinking skills after intervention.To compare the critical thinking skills survey score before and after.

Detailed description: Through the countermeasure 1-ABC rescue training: Clarify the positions and perform their duties; Countermeasure 2-Advanced Life Support (ACLS) training: Clear division of labor and strengthen the cooperation Tune; Countermeasure 3-Objective Structural Clinical Test (OSCE Exam): Objective, orderly, and organized assessment. The framework and group competitions are evaluated to promote teaching and other measures.The comparison experimental objects use the data of the two questionnaires before and after the PDCA cycle management. Explore the application effect of PDCA circular management within five years of employment.

Eligibility criteria: Inclusion Criteria: (1) ICU nurse within five years of joining the ICU

(2) Voluntary participation in this study.

-

Exclusion Criteria:(1) Clinical nurses who have worked for more than 5 years

(2) Involuntary participation in this study.

-

Primary outcomes:
measure: critical thinking
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: One Case of Individualized Nursing Plan for Sepsis
state: Guangdong
Study officials:
affiliation: colleague
name: huiying Fuhuiying
role: PRINCIPAL_INVESTIGATOR
References:
citation: Boso CM, van der Merwe AS, Gross J. Critical thinking disposition of nursing students: A quantitative investigation. Nurse Educ Pract. 2021 Aug;55:103167. doi: 10.1016/j.nepr.2021.103167. Epub 2021 Jul 30.
citation: Christodoulakis A, Zografakis Sfakianakis M, Tsiligianni I. Suggestions for overcoming the barriers to critical thinking in nursing. Jpn J Nurs Sci. 2023 Jul;20(3):e12525. doi: 10.1111/jjns.12525. Epub 2023 Feb 8.
Clinical trial NCT01981083: Egg Albumin-Based Protein Supplement Versus Renal-specific Supplement in Hemodialysis Patients
Official title: Randomized, Open Label, Controlled Clinical Trial of Egg Albumin-Based Protein Supplement Versus Renal Specific Oral Supplement in Hemodialysis Patients
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Protein-Energy Malnutrition
Kidney Failure, Chronic
Hemodialysis
Keywords: Protein-Energy Malnutrition
Chronic Kidney Disease
Malnutrition-Inflammation Score
Subjective Global Assessment
Hemodialysis
Egg albumin
Lead sponsor: Centro Medico Lic Adolfo Lopez Mate
Sponsor class: OTHER_GOV
First posted: 2013-11-11
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Malnutrition is seen frequently in hemodialysis units in most developing countries. Malnutrition increases morbidity and mortality in this population and its treatment improves patient survival and health status The purpose of this study is to compare two strategies to improve nutritional status in hemodialysis patients: renal-specific oral supplement (237 ml) versus egg albumin-based protein supplement (30 g) on a daily basis.

This trial uses the Malnutrition Inflammation Score (MIS) and Subjective Global Assessment (SGA) in addition to most used biochemical markers to determine nutritional status.


Eligibility criteria: Inclusion Criteria:

* Chronic Kidney Disease in Hemodialysis

Exclusion Criteria:

* Infection
* Liver insufficiency
* Cancer or neoplasia
* Acquired immunodeficiency syndrome
* Intestinal malabsorption syndrome

Primary outcomes:
measure: Change in Malnutrition-Inflammation Score
timeFrame: Bimonthly, up to six months
measure: Change in Subjective Global Assessment
timeFrame: Bimonthly, up to six months
Secondary outcomes:
Other outcomes:
Locations:
city: Toluca
country: Mexico
facility: Centro Medico Lic. Adolfo López Mateos
state: Estado de Mexico
Study officials:
References:
Clinical trial NCT03811483: SepsisFLAGS ( FLuidAndGender)
Official title: Fluid Treatment and the Impact of Gender in a Septic Population
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Sepsis
Keywords: Fluid Therapy
Gender difference
Lead sponsor: Karolinska Institutet
Sponsor class: OTHER
First posted: 2019-01-22
Enrollment: 5000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: PROBABILITY_SAMPLE
Study population: The population is patients admitted at the emergency department at Södersjukhuset in Southern Stockholm. Södersjukhuset has 600 hospital beds and manages most medical fields except for highly specialized care for example neuro and thoracic surgery. 130 000 patients are seeking medical care yearly which makes the emergency department at Södersjukhuset the most frequented in Scandinavia.

Brief summary: In this single-center study the investigators will analyze gender differences among patients with suspected sepsis admitted to the Emergency Department at Södersjukhuset during a period of two years. About 11 000 patients will be included. Patient data including fluid therapy will be drawn from the electronic medical record; Take Care and Clinisoft. In the logistic regression analysis, the investigators will adjust for age, gender, comorbidities, vital signs, preliminary focus of infection, level of care and renal replacement therapy. The aim is to analyze gender differences in fluid treatment and the response to fluid treatment and if the treatment is associated with differences in mortality.


Eligibility criteria: Inclusion Criteria:

* Patients admitted to the emergency department with suspected sepsis (defined by blood culture taken and intravenous sepsis-antibiotics prescribed within 48 hours) and fulfilling sepsis-3 definition of sepsis (sequential organ failure assesment score of 2 or more)

Exclusion Criteria:

* Patients transferred from other hospitals or treatment clinics.

Primary outcomes:
measure: Gender differences in fluid treatment
timeFrame: Fluid therapy during the first six hours (adherence to sepsis bundles) and the first five days after admission.
Secondary outcomes:
measure: Association between amount of fluid and mortality
timeFrame: In-Hospital Mortality, 30- and 90-days mortality
measure: Type of fluids
timeFrame: First five days after admission.
measure: Association between fluid therapy and levels of lactat
timeFrame: First five days efter admission
measure: Association between fluid therapy and need for/ dose of vasopressors/inotropic drugs
timeFrame: First five days efter admission
Other outcomes:
Locations:
city: Stockholm
country: Sweden
facility: Södersjukhuset
state: Stockholms Län
Study officials:
affiliation: Karolinska Institutet, Södersjukhuset
name: Sandra Jonmarker
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05344183: Immediate and Short-term Effects of Low-level Laser
Official title: Immediate and Short-term Effects of Low-level Laser on the Functional Performance of the Lower Limbs of Jumping Athletes
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Fatigue
Muscle Injury
Lead sponsor: Universidade Federal do Amapá
Sponsor class: OTHER
First posted: 2022-04-25
Enrollment: 24
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Athletes experience an exhaustive routine of training, associated with the reduced time of rest, facilitates the appearance of muscle fatigue, which increases the risk of muscle injuries, especially during the execution of the jump. Low Level Lasertherapy is a technique that has been increasingly improved due to the physiological effects it provides in the muscle recovery process. However, there is still a lack of studies focused on the use of this technique in functional improvement, especially in jumping sports. Objectives: To evaluate the immediate and short-term effects of low-level laser on the functional performance of lower limbs of jumping athletes and to evaluate the short-term effects of low-level laser on the activation of the gluteus medius and quadriceps muscles. Methods: This is a brief, double-blind, randomized, placebo-controlled clinical trial. Will be recruited 24 handball and volleyball players aged between 18 to 35 years. The primary outcome of our study is functional performance (modified hop test and modified SEBT), and as a secondary outcome (level of electromyographic activity). After the baseline assessments, the athletes will be randomized and allocated into two groups: Intervention Group (IG, n=12) and Control Group (CG, n=12) and submitted to a fatigue protocol, followed by laser therapy or placebo.


Eligibility criteria: Inclusion Criteria:

* Handball and volleyball athletes;
* Age between 18 and 35 years;
* Both sexes;
* Athletes who maintain a training routine for their sport, at least twice a week

Exclusion Criteria:

* History of acute injury to the lower limbs (LL) in the last 2 months;
* Occurrence of pain and injury during the study;
* Any change in physical activity routine during the week of assessments.

Primary outcomes:
measure: Functional Performance
timeFrame: 6 days
Secondary outcomes:
measure: Muscle activity
timeFrame: 2 days
Other outcomes:
Locations:
city: Macapá
country: Brazil
facility: Renan Lima Monteiro
state: Amapá
Study officials:
References:
Clinical trial NCT04903483: Anesthesia of Endolaryngeal Laser Surgery and Perioperative Side Effects
Official title: Anesthesia of Endolaryngeal Laser Surgery and Perioperative Side Effects
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Anesthesia
Keywords: laser, anesthesia, bispectral index, postoperative delirium
Lead sponsor: University of Pecs
Sponsor class: OTHER
First posted: 2021-05-26
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: the side effects of endolaryngeal laser surgery's anesthesia with or without bispectral index monitoring in patients with smoking
Primary purpose: OTHER

Brief summary: Investigators analyze the anesthesia of the endolaryngeal laser surgery in patients with smoking with or without monitoring of depth of anesthesia (bispectral index)

Detailed description: All participants are informed about the investigation and are signed the Informed Consent before anesthesia. The study takes place at the Department of Otorhinolaryngology, University of Pecs, Hungary. Between June 2021 and May 2022 ASA I or II patients aged 18-65 years, scheduled for elective endolaryngeal laser surgery with TCI (target-controlled infusion, propofol). Exclusion criteria are epilepsy, psychiatric illness, cerebrovascular or congenital neuromuscular disease. Participants are randomized to two anesthetic groups, anesthesia with or without bispectral index monitoring.

Eligibility criteria: Inclusion Criteria:

* endolaryngeal laser surgery with target-controlled anesthesia

Exclusion Criteria:

* epilepsy, psychiatric illness, cerebrovascular or congenital neuromuscular disease

Primary outcomes:
measure: circulation
timeFrame: through study completion, an average of 1 year
measure: cardiac function
timeFrame: through study completion, an average of 1 year
measure: oxygenization
timeFrame: through study completion, an average of 1 year
measure: ventilation
timeFrame: through study completion, an average of 1 year
measure: depth of anesthesia
timeFrame: through study completion, an average of 1 year
Secondary outcomes:
measure: cognitive functions
timeFrame: through study completion, an average of 1 year
Other outcomes:
Locations:
city: Pécs
country: Hungary
facility: Department of Anaesthesiology and Intensive Therapy
state: Ifjuság Str.13.
city: Pecs
country: Hungary
facility: PTE Department of ENT
Study officials:
affiliation: University of Pecs Department of ENT
name: Burian Andras, MD
role: STUDY_CHAIR
References:
Clinical trial NCT04868383: Using Smart Phone Technology to Support PrEP Uptake and Adherence
Official title: Using Smart Phone Technology to Support PrEP Uptake and Adherence in Virginia - Pilot Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: HIV Prevention
PrEP
Adherence, Medication
Keywords: HIV
Prevention
Adherence
Uptake
Lead sponsor: University of Virginia
Sponsor class: OTHER
Collaborators: name: Virginia Department of Health
First posted: 2021-04-30
Enrollment: 62
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: This is a single arm pilot study of a new smartphone app to support adherence to PrEP medication for HIV prevention in public clinics in Virginia.

Detailed description: Testing the impact of a smart phone application's impact on PrEP uptake and adherence.

The app features daily medication reminders, daily mood and stress evaluations, a community message board for social support, and patient-provider secure, HIPAA compliant private messaging between patients and clinic providers. Participants will be recruited from VDH clinics. We will evaluate the adherence and uptake rates of PrEP among study participants. Usage data will be collected from the application, and from participant surveys at 30 day, 3 month, and 6 month study timepoints. Surveys will include questionnaires on medication adherence, empathy of providers, experiences with the app, stigma and disclosure attitudes, and social support, along with mental health screening. The study will be analyzed as a prospective one arm study by comparing baseline to 3M and 6M surveys, along with examining and characterizing app usage across time.

Eligibility criteria: Inclusion Criteria:

* 18 years of age or older
* one or considering being on PrEP for HIV prevention
* Patient at a VDH or VDH funded clinic
* ability to read at a 5th grade reading level

Exclusion Criteria:

* HIV positive individuals
* Persons under the age of 18

Primary outcomes:
measure: Adherence
timeFrame: 6 months
Secondary outcomes:
measure: Usability
timeFrame: 6 months
Other outcomes:
Locations:
city: Charlottesville
country: United States
facility: Virginia Department of Health
state: Virginia
Study officials:
References:
Clinical trial NCT03637283: Anti-VEGF Instead of Intraoperative Fan-shaped Photocoagulation in BRVO Combined With Vitreous Hemorrhage
Official title: Feasibility Study of Anti-VEGF Instead of Intraoperative Fan-shaped Photocoagulation in BRVO Combined With Vitreous Hemorrhage
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Anti-VEGF
Branch Retinal Vein Occlusion
Vitrectomy
Lead sponsor: Wenzhou Medical University
Sponsor class: OTHER
First posted: 2018-08-17
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To evaluate the efficacy and safety of Anti-VEGF instead of intraoperative fan-shaped photocoagulation in BRVO combined with vitreous hemorrhage.


Eligibility criteria: Inclusion Criteria:

1. Age ≥ 18 years old;
2. BRVO is diagnosed
3. Vitreous hemorrhage
4. Vitreous hemorrhage combined with mild retinal fibrovascular proliferation (early fibrous vascular membrane, thin fibrous vascular membrane, loose retinal adhesion and intact local retinal structure)

Exclusion Criteria:

1. BRVO combined with severe retinal fibrovascular proliferation (long-term fibrovascular membrane, thick fibrous vascular membrane and tightly attached to the retina, deformation of local retinal, retinal tear or suspension of retinal vein )
2. BRVO combined with retinal detachment
3. Retinal veins are completely whitened
4. iris neovascularization or neovascular glaucoma
5. Combined glaucoma
6. combined with other retinopathy
7. Received anti-VEGF treatment within 3 months before surgery

Primary outcomes:
measure: Mean change from baseline in best-corrected visual acuity (BCVA)
timeFrame: 3 years
Secondary outcomes:
measure: Mean change from baseline in visual field
timeFrame: 3 years
measure: chang from baseline in structure of retina
timeFrame: 3 years
measure: chang from baseline in retinal neovascularization
timeFrame: 3 years
Other outcomes:
Locations:
Study officials:
affiliation: The Eye Hospital of Wenzhou Medical University
name: Yong Wei, M.D
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03668483: Relation Between Muscle Strength With Exercise Capacity and Dyspnea in LTx
Official title: Relation Between Upper and Lower Limb Muscle Strength With Exercise Capacity and Dyspnea in Patients With Awaiting Lung Transplantation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Lung Transplantation
Pulmonary Rehabilitation
Keywords: rehabilitation
exercise
maximal inspiratory pressure
walk test
muscle strength
dyspnea
lung transplantation
Lead sponsor: Istanbul Medipol University Hospital
Sponsor class: OTHER
First posted: 2018-09-12
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Severe exercise intolerance and shortness of breath are present in lung transplant candidates. Clinical features that reveal these symptoms in terminal period lung patients vary and are unclear. The effect of peripheral muscle strength on exercise capacity and dyspnea will be examined in our study.

Detailed description: Yedikule Chest Diseases Patients who have been accepted to participate in the pre-operative rehabilitation program at the Pulmonary Rehabilitation Unit will be included in the study. A 6-min walk test, peripheral and respiratory muscle strength measurements, and a dyspnea rating scale Mmrc will be applied to the lung transplantation candidates who are trained in 3-month hospital-based preoperative exercise training in the Pulmonary Rehabilitation unit. The tests will be carried out at the beginning and end of rehabilitation. At each testing session, the tests will be performed by the same physiotherapist. The correlations of the test data with each other will be analyzed.

Eligibility criteria: Inclusion Criteria:

* have a diagnosis of terminally severe lung disease,
* being listed for lung transplantation,
* medically stable,
* had no orthopedic or cardiac problems that would prevent them from exercising
* had no transfer problem to the pulmonary rehabilitation center.

Exclusion Criteria:

* Dont except to participate the study
* incompatibility with exhaust
* not completing the program

Primary outcomes:
measure: Changes from baseline the muscle strength
timeFrame: 15 minutes
measure: Changes from baseline the hand grip strength.
timeFrame: 5 minutes
measure: Changes from baseline the maximum inspiratory muscle pressure
timeFrame: 15 minutes
measure: Changes from baseline the distance covered in six-minute walk test
timeFrame: 20 minutes
measure: Changes from baseline the modified Medical Research Council (mMRC) scale
timeFrame: 5 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Yedikule Chest Disease Hospital
state: Zeytinburnu
Study officials:
References: