Clinical trial NCT02819128: Investigation of Endemic and Emerging Diseases in Populations of Homeless Households in Marseille.
Official title: Investigation of Endemic and Emerging Diseases in Populations of Homeless Households in Marseille.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Endemic and Emerging Diseases in Populations of Homeless
Lead sponsor: Assistance Publique Hopitaux De Marseille
Sponsor class: OTHER
First posted: 2016-06-30
Enrollment: 722
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Hypothesis:

Homeless people have infections not diagnosed with a potential impact on their health status.

Main Purpose: Improve the etiological diagnosis of endemic and/or emerging pathologies among homeless people.

Detailed description: In Marseilles, the population of homeless is estimated at 1500 individuals, including 800 usually sleeping in the street, 600 in foster homes and a hundred in the structures of care. The precarious living conditions of homeless persons promote the emergence or re-emergence of many communicable infectious diseases homeless people whose symptoms are often overlooked by the subject and rarely established etiologic diagnosis.

Among these diseases, frequently described in the literature are infestation by lice and infectious diseases that they transmit (Bartonella quintana), skin infections, hepatitis E and C and finally the infection with Tropheryma Whipplei. In this study we propose to systematically in homeless subject an etiological diagnosis of pathogens at the origin of these diseases (i) to improve knowledge (ii) to improve their management, (iii) to limit the contagion.

Eligibility criteria: Inclusion Criteria:

* Homeless Subject on the day of the study in one of two shelters for homeless Marseille ( Madrague City and Forbin )
* Major subject ( \> or equal to 18 years)
* Freely about having signed the written informed consent,
* About affiliated with a social security scheme

Exclusion Criteria:

* Minor Subjects ( \< 18 years )
* Major subject under guardianship (L. 1121-8 )
* Subject privated of freedom or under court order (L. 1121-6 )
* Subject refusing to sign the informed consent form ,
* Subject not affiliated with a social security insurance
* Pregnant women , parturient or nursing (L. 1121-7 ) .

Primary outcomes:
measure: Percentage of subjects with an established microbiological diagnosis
timeFrame: 3 years
Secondary outcomes:
measure: Prevalence of skin infections
timeFrame: 1 day
measure: Prevalence of Tropheryma whipplei infections
timeFrame: 1 day
measure: Prevalence of infestation by body lice
timeFrame: 1 day
measure: Percentage of body lice resistant to permethrin
timeFrame: 1 day
measure: Prevalence of infections by Bartonella quintana
timeFrame: 1 day
measure: Prevalence of infection by hepatitis E and C
timeFrame: 1 day
Other outcomes:
Locations:
city: Marseille
country: France
facility: Assistance Publique Hopitaux de Marseille
Study officials:
affiliation: Assistance Publique - Hôpitaux de Marseille
name: Philippe BROUQUI, Pr
role: PRINCIPAL_INVESTIGATOR
References: