Clinical trial NCT03915483: Transfer Effects of Combined Attentional Filter Exercise and Transcranial Direct Current Stimulation
Official title: Cognitive Transfer Effects on Working Memory and Higher Cognitive Functions by Combined Attentional Filter Exercise and tDCS in Healthy Younger Adults
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Healthy
Lead sponsor: German Center for Neurodegenerative Diseases (DZNE)
Sponsor class: OTHER
First posted: 2019-04-16
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Investigation of how a single session of an attentional filter exercise of distractor inhibition combined with tDCS modulates cognitive functions like working memory, decision making and attentional control.

Detailed description: The study is designed as a between subject design with two groups defined by real or sham tDCS. The distractor inhibition exercise is conducted under either sham or real tDCS. Cognitive performance is assessed pre and post tDCS application, complemented by a short-termed follow-up on a consecutive day. Interindividual working memory capacity at baseline is taken into consideration.

Eligibility criteria: Inclusion Criteria:

* right-handed
* aged between 18 and 30 years
* normal or corrected to normal vision
* German-speaking

Exclusion Criteria:

* dyschromatopsia
* neurological or neuropsychiatric diseases
* low seizure threshold
* neurological medication
* metal implants in the head

Primary outcomes:
measure: Performance change in computerized attentional filter exercise
timeFrame: 45 minutes on 1st day (pre) and on consecutive day (post)
measure: Reaction change in computerized attentional filter exercise
timeFrame: 45 minutes on 1st day (pre) and on consecutive day (post)
measure: Performance change in working memory and filtering performance
timeFrame: 30 minutes per pre-assessment, post assessment directly after intervention and short-termed follow-up on the consecutive day
measure: Reaction change in working memory and filtering performance
timeFrame: 30 minutes per pre-assessment, post assessment directly after intervention and short-termed follow-up on the consecutive day
Secondary outcomes:
measure: Spatial Span
timeFrame: 10 minutes per pre-assessment and short-termed follow-up on the consecutive day
measure: Iowa Gambling Task
timeFrame: 7 minutes per pre-assessment, post assessment directly after intervention and short-termed follow-up on the consecutive day
measure: Trait-Anxiety
timeFrame: 2 minutes on first day
measure: State-Anxiety
timeFrame: 2 minutes on first and consecutive day
measure: Assessment of Sleep Quality
timeFrame: 10 minutes on first and consecutive day
measure: Daily Performance Questionnaires
timeFrame: 5 minutes on first and consecutive day
measure: Daily Strategy Questionnaires
timeFrame: 5 minutes on first and consecutive day
Other outcomes:
Locations:
city: Magdeburg
country: Germany
facility: German Center for Neurodegenerative Diseases
state: Sachsen-Anhalt
Study officials:
affiliation: German Center for Neurodegenerative Diseases (DZNE)
name: Notger Müller, Prof. Dr.
role: PRINCIPAL_INVESTIGATOR
References: