Clinical trial NCT03059771: Mobile Enhancement of Motivation in Schizophrenia
Official title: Mobile Enhancement of Motivation in Schizophrenia: A Pilot Trial of a Personalized Text Message Intervention for Motivation Deficits
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Schizophrenia
Schizo Affective Disorder
Psychosis
Lead sponsor: Indiana University
Sponsor class: OTHER
Collaborators: name: Indiana Clinical and Translational Sciences Institute
name: American Psychological Foundation
name: Indiana University-Purdue University Indianapolis Department of Psychology
First posted: 2017-02-23
Enrollment: 59
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Motivation deficits are a strong determinant of poor functional outcomes in people with schizophrenia. Mobile interventions are a promising approach to improving these deficits, as they can provide frequent cues and reinforcements that support goal-directed behavior. The primary aims of this study are to conduct a pilot study using a randomized design to 1) Test the feasibility and acceptability of a personalized mobile text message intervention, Mobile Enhancement of Motivation in Schizophrenia (MEMS) and to 2) Test the preliminary effectiveness of MEMS compared to a control condition.

Detailed description: Objectives: Motivation deficits are one of the strongest determinants of poor functional outcomes in people with schizophrenia. Mobile interventions are a promising approach to improving these deficits, as they can provide frequent cues and reinforcements that support goal-directed behavior. The objective of this study is to conduct a pilot study using a randomized design to 1) Test the feasibility and acceptability of a personalized mobile text message intervention, Mobile Enhancement of Motivation in Schizophrenia (MEMS) and to 2) Test the preliminary effectiveness of MEMS compared to a control condition. Methods: Up to forty outpatients with a schizophrenia-spectrum disorder will be recruited. All participants will set individualized recovery goals to complete over an eight-week period; those randomized to receive MEMS will also receive three sets of personalized, interactive text messages each weekday to reinforce and cue goal completion. Before and after the eight-week period, participants in both groups will complete validated measures of motivation. Both groups will also report their goal attainment after eight weeks. Results: It is anticipated that those in the MEMS group will demonstrate greater goal attainment and improvements in motivation compared to the control group. Discussion: This project will test the initial feasibility, acceptability, and effectiveness of a novel intervention for improving one of the most debilitating aspects of schizophrenia.

Eligibility criteria: Inclusion Criteria:

* Schizophrenia-spectrum diagnosis
* Have a text-message enabled cell-phone
* Are a current client at a participating community mental health center
* Are in a non-acute phase of illness or have no medication changes or hospitalizations in the prior 30 days
* Demonstrate a minimum of moderate motivation impairments according to the Clinical Assessment Interview for Negative Symptoms (CAINS; Kring et al., 2013)
* Have an English reading level at or above the fourth grade according to the Graded Word List (Pray \& Ross, 1969)

Primary outcomes:
measure: Goal completion
timeFrame: follow-up (8 weeks)
Secondary outcomes:
measure: Motivation and Pleasure Scale-Self-Report (MAP-SR)
timeFrame: baseline and follow-up (8 weeks)
measure: Intrinsic Motivation Index
timeFrame: baseline and follow-up (8 weeks)
Other outcomes:
Locations:
city: Indianapolis
country: United States
facility: Midtown Community Mental Health Center
state: Indiana
Study officials:
References:
citation: Luther L, Fischer MW, Johnson-Kwochka AV, Minor KS, Holden R, Lapish CL, McCormick B, Salyers MP. Mobile enhancement of motivation in schizophrenia: A pilot randomized controlled trial of a personalized text message intervention for motivation deficits. J Consult Clin Psychol. 2020 Oct;88(10):923-936. doi: 10.1037/ccp0000599. Epub 2020 Aug 13.