Clinical trial NCT04666870: Axis Length and Its Relationship With Refractive Error in Chinese University Students
Official title: Shanghai Guanghua Integrated Traditional Chinese and Western Medicine Hospital, Guanghua Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai, China
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Refractive Error - Myopia Axial
Keywords: China
high myopia
hyperopia
emmetropia
Lead sponsor: Shanghai Guanghua Hospital of Integrated Traditional Chinese and Western Medicine
Sponsor class: OTHER
Collaborators: name: Tianjin Eye Hospital
First posted: 2020-12-14
Enrollment: 1901
Sex: ALL
Minimum age (years): 22
Maximum age (years): 26
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The subject recruited for the study were 1935 students

Brief summary: To investigate the relationship between axis length (AL) and refractive error. eyes of low hyperopia to emmetropia subjects, comprising eyes with moderate to high myopia (-11.00D ≤ SE ≤ -4.00D) were analyzed in this cross-sectional study. Cycloplegic refractive error was measured with the autorefractor, AL was measured with the IOL master. Association between AL and refractive error were evaluated by linear regression analysis. The mean of AL and its correlation with SE, sex, and age were evaluated.

Detailed description: To investigate the relationship between axis length (AL) and refractive error (RE). 894 eyes with low hyperopia to emmetropia (-0.50D ≤ spherical equivalent (SE) ≤ +2.00D), comprising 1007 eyes with moderate to high myopia (-11.00D ≤ SE ≤ -4.00D) were analyzed in this study. Cycloplegic RE was measured with the autorefractor, AL was measured with the IOL master. Association between AL and refractive error were evaluated by linear regression analysis. The mean of AL and its correlation with SE, sex, and age were evaluated.

Eligibility criteria: Inclusion Criteria:

with moderate to high myopia (SE ≤ -4.00D) without myopia (-0.50D ≤ spherical power ≤ +2.00D) no concurrent eye disease best corrected visual acuity is 1.0

Exclusion Criteria:

significant systemic illnesses congenital myopia, media opacity uveitis glaucoma intraocular surgery refractive surgery neurologic diseases retinal disease

Primary outcomes:
measure: Axis length
timeFrame: from baseline at 6 months
measure: Refractive Error
timeFrame: from baseline at 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Shanghai Guanghua Integrated Traditional Chinese and Western Medicine Hospital
state: Shanghai
Study officials:
affiliation: Shanghai Guanghua integrated traditional Chinese and Western Medicine Hospital
name: Hongxia Wang, director
role: STUDY_DIRECTOR
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