Clinical trial NCT03288805: Cohort Study in South China
Official title: Prospective Cohort Study of Chronic Diseases in South China
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Chronic Disease
Lead sponsor: Sun Yat-sen University
Sponsor class: OTHER
Collaborators: name: Guangxi Medical University
name: Hainan Medical College
name: Guangzhou No.12 People's Hospital
name: Fujian Medical University
name: The First Affiliated Hospital of Xiamen University
name: Shenzhen Fifth People's Hospital
name: Guangzhou Medical University
First posted: 2017-09-20
Enrollment: 110000
Sex: ALL
Minimum age (years): 35
Maximum age (years): 74
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult Chinese (35-74 years old) who have been living in South China including Guangdong, Fujian, Guangxi and Hainan provinces for more than 5 years.

Brief summary: Healthy Chinese residents from South China will be recruited and followed up for at least 4 years to evaluate the association between climate, diet and lifestyle and risks for the development of chronic diseases. Physical examination, questionnaire survey and biological sample collection will be conducted at baseline and the incidence of chronic diseases will be investigated during follow-up.

Detailed description: 110,000 adult Chinese (35 to 74 years old) without chronic diseases and major disability who have been living in South China including Guangdong, Fujian, Guangxi and Hainan for more than 5 years will be recruited. All participants will be prospectively followed up for the incidence of chronic diseases (stroke, coronary heart disease, malignant neoplasms, chronic obstructive pulmonary diseases, diabetes and hypertension) and their risk factors (impaired glucose tolerance and obesity). Information about socio-demographic, diet, lifestyle, psychological status, medical history and current medication will be collected by questionnaires. Physical examinations including height, weight, waist and hip circumferences, blood pressure, fat mass and vital capacity will be conducted. Besides, blood, urine and fecal samples will be collected for further analysis. Annual meteorological data throughout the study period will also be collected. The associations between climate, diet and lifestyle and risks for chronic diseases will be evaluated.

Eligibility criteria: Inclusion Criteria:

* adult Chinese (35-74 years old) who have been living in South China including Guangdong, Fujian, Guangxi and Hainan provinces for more than 5 years.

Exclusion Criteria:

* any subject diagnosed with stroke, coronary heart disease, malignancy, chronic obstructive pulmonary disease, diabetes and hypertension.
* any subject who suffer from major disability and cannot participate in the study.

Primary outcomes:
measure: Incidence of chronic disease
timeFrame: 4 years
Secondary outcomes:
measure: Risk factors for chronic diseases
timeFrame: 4 years
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Sun Yat-Sen University
state: Guangdong
Study officials:
affiliation: School of Public Health,Nutrition and Food Hygiene,Sun Yat-sen University
name: Min Xia
role: PRINCIPAL_INVESTIGATOR
References: