Clinical trial NCT06890598: Study of Olomorasib (LY3537982) in Combination With Standard of Care in Participants With Resected or Unresectable KRAS G12C-mutant Non-Small Cell Lung Cancer
Official title: A Phase 3, Multicenter, Double-Blind, Placebo-controlled Study Assessing the Efficacy and Safety of Olomorasib in Combination With Standard of Care Immunotherapy in Participants With Resected or Unresectable KRAS G12C-Mutant, Non-Small Cell Lung Cancer - SUNRAY-02
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE3
Conditions: Carcinoma, Non-Small-Cell Lung
Lead sponsor: Eli Lilly and Company
Sponsor class: INDUSTRY
Collaborators: name: AstraZeneca
First posted: 2025-03-24
Enrollment: 700
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The main purpose of this study is to assess if olomorasib in combination with pembrolizumab is more effective than the pembrolizumab and placebo combination in part A in participants with resected KRAS G12C-mutant NSCLC and to assess if olomorasib in combination with durvalumab is more effective than the durvalumab and placebo combination in part B in participants with unresectable KRAS G12C-mutant non-small cell lung cancer. The study may last up to 3 years for each participant.


Eligibility criteria: Inclusion Criteria:

* Histological or cytological confirmation of NSCLC.

  * Part A

    1. Clinical Stage II-IIIB (N2) treated with presurgical chemoimmunotherapy, with residual tumor present at time of surgery. Patients with a pathologic complete response are not eligible.
    2. Pathologic Stage II-IIIB (N2) NSCLC treated with initial upfront resection.
  * Part B - Clinical Stage III, unresectable NSCLC, without progression on concurrent platinum-based chemoradiotherapy.
* Must have disease with evidence of KRAS G12C mutation.
* Must have known programmed death-ligand 1 (PD-L1) expression
* Must have an ECOG performance status of 0 or 1.
* Able to swallow oral medication.
* Must have adequate laboratory parameters.
* Contraceptive use should be consistent with local regulations for those participating in clinical studies.
* Women of childbearing potential must

  * Have a negative pregnancy test.
  * Not be breastfeeding during treatment

Exclusion Criteria:

* Have known changes in the EGFR or ALK genes.
* Have another type of cancer that is progressing or required active treatment within the past 3 years before screening.
* Have an active autoimmune disease that required systemic treatment in the past 2 years. Endocrine replacement therapy is allowed.
* Had any immune-related side effect or allergic reaction (Grade 3 or higher) from a previous immunotherapy medicine, or any immune-related side effect greater than Grade 1 that has not resolved. This does not apply for people with hormone-related diseases who are now on stable hormone replacement therapy.

Primary outcomes:
measure: Part A: Disease-Free Survival (DFS) by Investigator Assessment
timeFrame: Randomization to disease recurrence or death from any cause (Estimated as approximately 48 months).
measure: Part B: Progression-Free Survival (PFS)
timeFrame: Randomization to disease progression or death from any cause (Estimated as approximately 3 years).
Secondary outcomes:
measure: Part A & B: Overall Survival (OS)
timeFrame: Randomization to disease progression or death from any cause (Estimated as approximately 5 years).
measure: Part A & B: Change from baseline in health-related quality of life (HRQoL), measured by European Organization for Research & Treatment of CancerQualityofLifeQuestionnaire-Core 30 (EORTC QLQ-C30)
timeFrame: Randomization through end of treatment (Estimated as approximately 3 years).
measure: Part B: Objective Response Rate (ORR) per RECIST 1.1 by BICR
timeFrame: Randomization to disease progression or death from any cause (Estimated as approximately 3 years).
measure: Part B: Duration of Response (DOR) per RECIST 1.1 by BICR
timeFrame: Randomization to disease progression or death from any cause (Estimated as approximately 3 years).
measure: Part B: Disease Control Rate (DCR) per RECIST 1.1 by BICR
timeFrame: Randomization to disease progression or death from any cause (Estimated as approximately 3 years).
measure: Part B: Time to Response (TTR) per RECIST 1.1 by BICR
timeFrame: Randomization until the date that measurement criteria for CR or PR (whichever is first recorded) are first met (Estimated as approximately 3 years).
measure: Part B: Progression-Free Survival 2 (PFS2) by investigator assessment
timeFrame: Randomization to disease progression on next line of treatment or death from any cause (Estimated as approximately 3 years).]
measure: Part B: Changes in Non-Small Cell Lung Cancer (NSCLC)-related symptoms, measured by the NSCLC-Symptom Assessment Questionnaire (SAQ)
timeFrame: Randomization through end of treatment (Estimated as approximately 3 years).
measure: Part B: Time to worsening of NSCLC-related symptoms, as measured by NSCLC-SAQ
timeFrame: Randomization through end of treatment (Estimated as approximately 3 years).
measure: Part B: Changes in patient-reported pulmonary symptoms of cough, chest pain, and dyspnea, measured by NSCLC-SAQ
timeFrame: Randomization through end of treatment (Estimated as approximately 3 years).
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: University of Alabama at Birmingham
state: Alabama
city: Huntsville
country: United States
facility: Clearview Cancer Institute
state: Alabama
city: Tucson
country: United States
facility: The University of Arizona Cancer Center - North Campus
state: Arizona
city: Springdale
country: United States
facility: Highlands Oncology Group
state: Arkansas
city: Los Angeles
country: United States
facility: UCLA Hematology/Oncology - Santa Monica
state: California
city: Oceanside
country: United States
facility: Profound Research LLC
state: California
city: Orange
country: United States
facility: University of California, Irvine (UCI) Health - UC Irvine Medical Center
state: California
city: Palo Alto
country: United States
facility: Stanford Cancer Center
state: California
city: San Diego
country: United States
facility: Kaiser Permanente San Diego Mission Road
state: California
city: Walnut Creek
country: United States
facility: BASS Cancer Center
state: California
city: Hartford
country: United States
facility: Hartford Hospital (HH)
state: Connecticut
city: Washington
country: United States
facility: Sibley Memorial Hospital
state: District of Columbia
city: Boca Raton
country: United States
facility: Boca Raton Regional Hospital
state: Florida
city: Fort Myers
country: United States
facility: Florida Cancer Specialists - South
state: Florida
city: Jacksonville
country: United States
facility: University of Florida - Jacksonville
state: Florida
city: Miami
country: United States
facility: Miami Cancer Institute at Baptist Health, Inc.
state: Florida
city: Saint Petersburg
country: United States
facility: Florida Cancer Specialists North
state: Florida
city: Saint Petersburg
country: United States
facility: Comprehensive Hematology Oncology
state: Florida
city: Tampa
country: United States
facility: Moffitt Cancer Center
state: Florida
city: West Palm Beach
country: United States
facility: Florida Cancer Specialists East
state: Florida
city: Chicago
country: United States
facility: University of Illinois at Chicago
state: Illinois
city: Chicago
country: United States
facility: University of Chicago Medical Center
state: Illinois
city: North Chicago
country: United States
facility: Captain James A. Lovell Federal Health Care Center
state: Illinois
city: Springfield
country: United States
facility: Springfield Clinic Main Campus
state: Illinois
city: Fort Wayne
country: United States
facility: Parkview Research Center at Parkview Regional Medical Center
state: Indiana
city: Indianapolis
country: United States
facility: Franciscan Health
state: Indiana
city: Westwood
country: United States
facility: The University of Kansas Cancer Center - Westwood
state: Kansas
city: Lexington
country: United States
facility: Baptist Health Lexington
state: Kentucky
city: Lexington
country: United States
facility: CHI Saint Joseph Cancer Center - East
state: Kentucky
city: Baton Rouge
country: United States
facility: Mary Bird Perkins Cancer Center
state: Louisiana
city: New Orleans
country: United States
facility: Ochsner Clinic Foundation
state: Louisiana
city: Baltimore
country: United States
facility: University of Maryland
state: Maryland
city: Baltimore
country: United States
facility: Johns Hopkins Bayview Medical Center
state: Maryland
city: Worcester
country: United States
facility: Reliant Medical Group
state: Massachusetts
city: Detroit
country: United States
facility: Karmanos Cancer Institute
state: Michigan
city: Saint Louis
country: United States
facility: Missouri Baptist Medical Center
state: Missouri
city: Hackensack
country: United States
facility: John Theurer Cancer Center at Hackensack University Medical Center
state: New Jersey
city: Buffalo
country: United States
facility: Roswell Park Cancer Institute
state: New York
city: New York
country: United States
facility: Columbia University Irving Medical Center
state: New York
city: New York
country: United States
facility: Memorial Sloan Kettering Cancer Center
state: New York
city: Northport
country: United States
facility: Northport VA Medical Center
state: New York
city: Cleveland
country: United States
facility: Cleveland Clinic
state: Ohio
city: Portland
country: United States
facility: Providence Portland Medical Center
state: Oregon
city: Portland
country: United States
facility: Providence St. Vincent Medical Center
state: Oregon
city: Portland
country: United States
facility: Kaiser Permanente Interstate Medical Office Central
state: Oregon
city: Portland
country: United States
facility: Oregon Health and Science University
state: Oregon
city: Philadelphia
country: United States
facility: Thomas Jefferson University, Sidney Kimmel Cancer Center - Clinical Trials Office
state: Pennsylvania
city: Pittsburgh
country: United States
facility: AHN Allegheny General Hospital
state: Pennsylvania
city: Charleston
country: United States
facility: Medical University of South Carolina
state: South Carolina
city: West Columbia
country: United States
facility: Lexington Medical Center
state: South Carolina
city: Chattanooga
country: United States
facility: Tennessee Oncology Chattanooga
state: Tennessee
city: Knoxville
country: United States
facility: University of Tennessee Medical Center
state: Tennessee
city: Nashville
country: United States
facility: Sarah Cannon Research Institute
state: Tennessee
city: Nashville
country: United States
facility: SCRI Oncology Partners
state: Tennessee
city: Nashville
country: United States
facility: Tennessee Oncology
state: Tennessee
city: Fort Worth
country: United States
facility: The Center for Cancer and Blood Disorders
state: Texas
city: Houston
country: United States
facility: Houston Methodist Hospital
state: Texas
city: Houston
country: United States
facility: University of Texas MD Anderson Cancer Center
state: Texas
city: San Antonio
country: United States
facility: USO - Texas Oncology - San Antonio
state: Texas
city: Sugar Land
country: United States
facility: USO - Texas Oncology Gulf Coast
state: Texas
city: The Woodlands
country: United States
facility: USO - US Oncology Research Network
state: Texas
city: Charlottesville
country: United States
facility: University of Virginia Health System
state: Virginia
city: Richmond
country: United States
facility: VCU Health Adult Outpatient Pavillion
state: Virginia
city: Edmonds
country: United States
facility: Swedish Cancer Institute - Edmonds
state: Washington
city: Seattle
country: United States
facility: Swedish Medical Center
state: Washington
city: Spokane Valley
country: United States
facility: Cancer Care Northwest - Vercler
state: Washington
city: Vancouver
country: United States
facility: Northwest Cancer Specialists PC
state: Washington
city: Milwaukee
country: United States
facility: Medical College of Wisconsin
state: Wisconsin
city: North Tamworth
country: Australia
facility: Tamworth Hospital
state: New South Wales
city: Auchenflower
country: Australia
facility: Icon Cancer Centre Wesley
state: Queensland
city: Birtinya
country: Australia
facility: Sunshine Coast University Hospital
state: Queensland
city: Kurralta Park
country: Australia
facility: ICON Cancer Centre - Kurralta Park
state: South Australia
city: Heidelberg
country: Australia
facility: Austin Health
state: Victoria
city: Shepparton
country: Australia
facility: Goulburn Valley Health
state: Victoria
city: Traralgon
country: Australia
facility: Latrobe Regional Health
state: Victoria
city: Perth
country: Australia
facility: Sir Charles Gairdner Hospital
state: Western Australia
city: Linz
country: Austria
facility: Ordensklinikum Linz GmbH Elisabethinen
state: Oberösterreich
city: Graz
country: Austria
facility: Medizinische Universität Graz
state: Steiermark
city: Wien
country: Austria
facility: Klinik Floridsdorf
city: Edegem
country: Belgium
facility: Antwerp University Hospital
state: Antwerpen
city: Auderghem
country: Belgium
facility: CHIREC - site delta
state: Bruxelles-Capitale, Région De
city: Leuven
country: Belgium
facility: UZ Leuven
state: Vlaams-Brabant
city: Roeselare
country: Belgium
facility: AZ Delta vzw
state: West-Vlaanderen
city: Fortaleza
country: Brazil
facility: Centro de Pesquisa Clínica do Instituto do Câncer do Ceará
state: Ceará
city: Belo Horizonte
country: Brazil
facility: Oncocentro de Minas Gerais
state: Minas Gerais
city: Londrina
country: Brazil
facility: Hospital de Cancer de Londrina
state: Paraná
city: Belem
country: Brazil
facility: CTO - Centro de Tratamento Oncológico
state: Pará
city: Natal
country: Brazil
facility: Liga Norte Riograndense Contra o Câncer
state: Rio Grande Do Norte
city: Bento Gonçalves
country: Brazil
facility: Hospital Tacchini
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Hospital São Lucas da PUCRS
state: Rio Grande Do Sul
city: Barretos
country: Brazil
facility: Fundação Pio XII - Hospital de Câncer de Barretos
state: São Paulo
city: Campinas
country: Brazil
facility: Centro de Pesquisa Sao Lucas
state: São Paulo
city: Sao Paulo
country: Brazil
facility: Instituto D'Or de Pesquisa e Ensino (IDOR)
state: São Paulo
city: Rio de Janeiro
country: Brazil
facility: Centro de Tratamento de Tumores Botafogo para Oncoclinicas Rio de Janeiro SA
city: Rio de Janeiro
country: Brazil
facility: Instituto D'Or Pesquisa e Ensino
city: São Paulo
country: Brazil
facility: Icesp - Instituto Do Câncer Do Estado de São Paulo
city: São Paulo
country: Brazil
facility: Hospital Santa Catarina - Paulista
city: São Paulo
country: Brazil
facility: Centro Paulista de Oncologia Clínica
city: Providencia
country: Chile
facility: K2 Oncology
state: Región Metropolitana De Santiago
city: Santiago
country: Chile
facility: FALP
state: Región Metropolitana De Santiago
city: Santiago
country: Chile
facility: Bradfordhill
state: Región Metropolitana De Santiago
city: Beijing
country: China
facility: Cancer Hospital Chinese Academy of Medical Science
state: Beijing
city: Beijing
country: China
facility: China-Japan Friendship Hospital
state: Beijing
city: Beijing
country: China
facility: Peking University People's Hospital
state: Beijing
city: Beijing
country: China
facility: Beijing Cancer hospital
state: Beijing
city: Chongqing
country: China
facility: The Second Affiliated Hospital Chongqing Medical University
state: Chongqing
city: Foshan
country: China
facility: The First People's Hospital of Foshan
state: Guangdong
city: Guangzhou
country: China
facility: Guangdong Provincial People's Hospital
state: Guangdong
city: Guangzhou
country: China
facility: The First Affiliated Hospital of Guangzhou Medical University
state: Guangdong
city: Shantou
country: China
facility: Cancer Hospital of Shantou University Medical College
state: Guangdong
city: Shenzhen
country: China
facility: ShenZhen People's Hospital
state: Guangdong
city: Shenzhen
country: China
facility: Cancer Hospital Chinese Academy of Medical Sciences. Shenzhen Center
state: Guangdong
city: Zhongshan
country: China
facility: Zhongshan Peoples Hospital
state: Guangdong
city: Liuzhou
country: China
facility: Liuzhou People's Hospital
state: Guangxi
city: Nanning
country: China
facility: Guangxi Medical University Affiliated Tumor Hospital
state: Guangxi
city: Harbin
country: China
facility: Harbin Medical University Cancer Hospital
state: Heilongjiang
city: Anyang
country: China
facility: Anyang Cancer Hospital
state: Henan
city: Luoyang
country: China
facility: The First Affiliated Hospital of Henan University of Science &Technology
state: Henan
city: Wuhan
country: China
facility: Tongji Hospital Tongji Medical,Science & Technology
state: Hubei
city: Wuhan
country: China
facility: Hubei Cancer Hospital
state: Hubei
city: Changsha
country: China
facility: Xiangya Hospital Central South University
state: Hunan
city: Changsha
country: China
facility: Xiangya Hospital Central South University
state: Hunan
city: Changsha
country: China
facility: Hunan Cancer Hospital
state: Hunan
city: Changsha
country: China
facility: Hunan Cancer Hospital
state: Hunan
city: Zhuzhou
country: China
facility: ZhuZhou Central Hospital
state: Hunan
city: Suzhou
country: China
facility: The First Affiliated Hospital of Soochow University
state: Jiangsu
city: Changchun
country: China
facility: Jilin Cancer Hospital
state: Jilin
city: Xi'an
country: China
facility: The First Affiliated Hospital of Xi'an Jiaotong University
state: Shaanxi
city: Jinan
country: China
facility: Jinan Central Hospital
state: Shandong
city: Jinan
country: China
facility: Shandong Cancer Hospital
state: Shandong
city: Shanghai
country: China
facility: Shanghai Chest Hospital
state: Shanghai
city: Shanghai
country: China
facility: Fudan University Shanghai Cancer Center
state: Shanghai
city: Shanghai
country: China
facility: Shanghai Pulmonary Hospital
state: Shanghai
city: Cheng Du
country: China
facility: West China Hospital, Sichuan University
state: Sichuan
city: Chengdu
country: China
facility: The Third People's Hospital of Chengdu (CDTPH)
state: Sichuan
city: Chengdu
country: China
facility: Sichuan Cancer hospital
state: Sichuan
city: Neijiang
country: China
facility: The Second People's Hospital of Neijiang
state: Sichuan
city: Tianjin
country: China
facility: Tianjin Medical University Cancer Institute & Hospital
state: Tianjin
city: Tianjin
country: China
facility: Tianjin Medical University Cancer Institute & Hospital
state: Tianjin
city: Hangzhou
country: China
facility: Zhejiang Provincial People's Hospital
state: Zhejiang
city: Hangzhou
country: China
facility: Zhejiang Cancer Hospital
state: Zhejiang
city: Hangzhou
country: China
facility: Zhejiang Cancer Hospital
state: Zhejiang
city: Hangzhou
country: China
facility: The Second Affiliated hospital of Zhejiang University school of medicine
state: Zhejiang
city: Linhai
country: China
facility: Taizhou Hospital of Zhejiang Province
state: Zhejiang
city: Ostrava
country: Czechia
facility: Nemocnice AGEL Ostrava - Vitkovice a.s.
state: Ostrava Město
city: Prague
country: Czechia
facility: Fakultni nemocnice Bulovka
state: Praha 8
city: Nice
country: France
facility: Centre Antoine-Lacassagne
state: Alpes-Maritimes
city: Pessac
country: France
facility: CHU Bordeaux Haut-Leveque
state: Aquitaine
city: Marseille
country: France
facility: Assistance Publique Hôpitaux de Marseille - Hôpital Nord
state: Bouches-du-Rhône
city: Toulouse
country: France
facility: CHU de Toulouse - Hopital Larrey
state: Haute-Garonne
city: Rennes
country: France
facility: Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou
state: Ille-et-Vilaine
city: La Tronche
country: France
facility: Chu Grenoble Alpes
state: Isère
city: Saint Herblain
country: France
facility: Institut de Cancérologie de l'Ouest
state: Loire-Atlantique
city: Vantoux
country: France
facility: Hôpital Robert Schuman
state: Lorraine
city: Reims
country: France
facility: Institut Jean Godinot
state: Marne
city: Lyon Cedex08
country: France
facility: Centre Leon Berard
state: Rhône-Alpes
city: Bron
country: France
facility: Hospices Civils de Lyon - Hopital Louis Pradel
state: Rhône
city: Villejuif
country: France
facility: Gustave Roussy
state: Val-de-Marne
city: Poitiers
country: France
facility: Centre Hospitalier Universitaire de Poitiers
state: Vienne
city: Paris
country: France
facility: Institut Curie
city: Paris
country: France
facility: Groupe hospitalier Paris saint Joseph
state: Île-de-France
city: Paris
country: France
facility: Hôpital Européen Georges Pompidou
state: Île-de-France
city: Heidelberg
country: Germany
facility: Thoraxklinik-Heidelberg gGmbH
state: Baden-Württemberg
city: Stuttgart
country: Germany
facility: Robert Bosch Krankenhaus GmbH
state: Baden-Württemberg
city: Tübingen
country: Germany
facility: Universitaetsklinikum Tuebingen
state: Baden-Württemberg
city: Donauwörth
country: Germany
facility: Onkologiezentrum Donauwörth
state: Bayern
city: Gauting
country: Germany
facility: Asklepios Fachkliniken München-Gauting
state: Bayern
city: Nürnberg
country: Germany
facility: Klinikum Nürnberg Nord
state: Bayern
city: Cologne
country: Germany
facility: MV-Zentrum für Onkologie und Hämatologie
state: Nordrhein-Westfalen
city: Düsseldorf
country: Germany
facility: Florence-Nightingale-Krankenhaus
state: Nordrhein-Westfalen
city: Köln
country: Germany
facility: Klinikum Köln-Merheim
state: Nordrhein-Westfalen
city: Halle
country: Germany
facility: Krankenhaus Martha-Maria Halle-Dölau
state: Sachsen-Anhalt
city: Chemnitz
country: Germany
facility: Klinikum Chemnitz
state: Sachsen
city: Leipzig
country: Germany
facility: St. Elisabeth-Krankenhaus Leipzig
state: Sachsen
city: Grosshansdorf
country: Germany
facility: LungenClinic Grosshansdorf
state: Schleswig-Holstein
city: Erfurt
country: Germany
facility: HELIOS Klinikum Erfurt
state: Thüringen
city: Berlin
country: Germany
facility: Vivantes Klinikum im Friedrichshain - Landsberger Allee
city: Berlin
country: Germany
facility: Evangelische Lungenklinik Berlin
city: Berlin
country: Germany
facility: DRK Kliniken Berlin Mitte
city: Georgsmarienhütte
country: Germany
facility: Franziskus-Hospital Harderberg
city: Hamburg
country: Germany
facility: Asklepios Klinik Harburg
city: Patras
country: Greece
facility: University Hospital of Patras
state: Achaḯa
city: Athens
country: Greece
facility: Agios Savvas Regional Cancer Hospital
state: Attikí
city: Athens
country: Greece
facility: Errikos Dunant Hospital Center
state: Attikí
city: Athens
country: Greece
facility: Thoracic General Hospital of Athens "I Sotiria"
state: Attikí
city: Heraklion
country: Greece
facility: University General Hospital of Heraklion
state: Irakleío
city: Thessaloniki
country: Greece
facility: Agios Loukas Clinic
state: Kentrikí Makedonía
city: Thessaloniki
country: Greece
facility: European Interbalkan Medical Center
state: Thessaloníki
city: Larissa
country: Greece
facility: University General Hospital of Larissa
state: Thessalía
city: Farkasgyepu
country: Hungary
facility: Farkasgyepui Tudogyogyintezet
state: Veszprém
city: Budapest
country: Hungary
facility: Országos Onkológiai Intézet
city: Budapest
country: Hungary
facility: Budapesti Uzsoki Utcai Kórház
city: Patna
country: India
facility: Savera Cancer & Multi Speciality Hospital
state: Bihar
city: New Delhi
country: India
facility: Rajiv Gandhi Cancer Institute And Research Centre
state: Delhi
city: Ahmedabad
country: India
facility: Hemato Oncology Clinic
state: Gujarat
city: Rohtak
country: India
facility: Pandit Bhagwat Dayal Sharma Post Graduate Institute of Medical Sciences
state: Haryana
city: Thalassery
country: India
facility: Malabar Cancer Centre - Thalassery
state: Kerala
city: Thiruvananthapuram
country: India
facility: Regional Cancer Centre - Thiruvananthapuram
state: Kerala
city: Aurangabad
country: India
facility: Galaxy Superspeciality Hospital
state: Maharashtra
city: Mumbai
country: India
facility: Sir H. N. Reliance Foundation Hospital and Research Centre
state: Maharashtra
city: Pune
country: India
facility: Deenanath Mangeshkar Hospital & Research Centre
state: Maharashtra
city: Pune
country: India
facility: Medipoint Hospitals Pvt. Ltd.
state: Maharashtra
city: Udaipur
country: India
facility: Pacific Medical College & Hospital
state: Rajasthan
city: Chennai
country: India
facility: Rajiv Gandhi Government General Hospital
state: Tamil Nadu
city: Namakkal
country: India
facility: Thangam Cancer Center - Namakkal
state: Tamil Nadu
city: Varanasi
country: India
facility: Tata Memorial Centre - Homi Bhabha Cancer Hospital
state: Uttar Pradesh
city: Kfar Saba
country: Israel
facility: Meir Medical Center
state: HaMerkaz
city: Ramat Gan
country: Israel
facility: Sheba Medical Center
state: HaMerkaz
city: Haifa
country: Israel
facility: Rambam Health Care Campus
state: HaTsafon
city: Jerusalem
country: Israel
facility: Shaare Zedek Medical Center
state: Yerushalayim
city: Meldola
country: Italy
facility: Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori
state: Emilia-Romagna
city: Monza
country: Italy
facility: Ospedale San Gerardo-ASST Monza
state: Lombardia
city: Milan
country: Italy
facility: ASST Grande Ospedale Metropolitano Niguarda
state: Milano
city: Naples
country: Italy
facility: Azienda Ospedaliera Dei Colli
state: Napoli
city: Orbassano
country: Italy
facility: Azienda Sanitaria Ospedaliera S Luigi Gonzaga
state: Piemonte
city: Bari
country: Italy
facility: Instituto Tumori Giovanni Paolo II
state: Puglia
city: Rome
country: Italy
facility: Istituto Nazionale Tumori Regina Elena
state: Roma
city: Catania
country: Italy
facility: Policlinico "G. Rodolico"
state: Sicilia
city: Verona
country: Italy
facility: Azienda Ospedaliera Universitaria Integrata Verona - Ospedale Borgo Trento
state: Veneto
city: Genova
country: Italy
facility: Ospedale San Martino
city: Nagoya
country: Japan
facility: Aichi Cancer Center Hospital
state: Aichi
city: Kashiwa
country: Japan
facility: National Cancer Center Hospital East
state: Chiba
city: Sapporo
country: Japan
facility: Hokkaido University Hospital
state: Hokkaido
city: Himeji
country: Japan
facility: Himeji Medical Center
state: Hyogo
city: Kanazawa
country: Japan
facility: Kanazawa University Hospital
state: Ishikawa
city: Yokohama
country: Japan
facility: Kanagawa Cardiovascular and Respiratory Center
state: Kanagawa
city: Yokohama
country: Japan
facility: Kanagawa cancer center
state: Kanagawa
city: Natori
country: Japan
facility: Miyagi Cancer Center
state: Miyagi
city: Niigata-shi
country: Japan
facility: Niigata Cancer Center Hospital
state: Niigata
city: Hirakata
country: Japan
facility: Kansai Medical University Hospital
state: Osaka
city: Sakai
country: Japan
facility: NHO Kinki Chuo Chest Medical Center
state: Osaka
city: Hidaka
country: Japan
facility: Saitama Medical University International Medical Center
state: Saitama
city: Nagaizumi-cho,Sunto-gun
country: Japan
facility: Shizuoka Cancer Center
state: Shizuoka
city: Bunkyo ku
country: Japan
facility: Tokyo Metropolitan Komagome Hospital
state: Tokyo
city: Bunkyo-ku
country: Japan
facility: Juntendo University Hospital
state: Tokyo
city: Koto
country: Japan
facility: The Cancer Institute Hospital of JFCR
state: Tokyo
city: Yonago
country: Japan
facility: Tottori University Hospital
state: Tottori
city: Fukuoka
country: Japan
facility: Kyushu University Hospital
city: Kyoto
country: Japan
facility: University Hospital,Kyoto Prefectural University of Medicine
city: Wakayama
country: Japan
facility: Wakayama Medical University Hospital
city: Cheongju-si
country: Korea, Republic of
facility: Chungbuk National University Hospital
state: Chungcheongbuk-do [Chungbuk]
city: Bupyeong-gu
country: Korea, Republic of
facility: The Catholic University of Korea, Incheon St. Mary's Hospital
state: Incheon-gwangyeoksi [Incheon]
city: Hwasun-gun
country: Korea, Republic of
facility: Chonnam National University Hwasun Hospital
state: Jeonranamdo
city: Goyang-si
country: Korea, Republic of
facility: National Cancer Center
state: Kyǒnggi-do
city: Seongnam
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
state: Kyǒnggi-do
city: Suwon-si
country: Korea, Republic of
facility: The Catholic University Of Korea St. Vincent's Hospital
state: Kyǒnggi-do
city: Yangsan
country: Korea, Republic of
facility: Pusan National University Yangsan Hospital
state: Kyǒngsangnam-do
city: Busan
country: Korea, Republic of
facility: Pusan National University Hospital
state: Pusan-Kwangyǒkshi
city: Gangnam-gu
country: Korea, Republic of
facility: Gangnam Severance Hospital, Yonsei University Health System
state: Seoul-teukbyeolsi [Seoul]
city: Seoul
country: Korea, Republic of
facility: The Catholic University of Korea, Eunpyeong St. Mary's Hospital
state: Seoul-teukbyeolsi [Seoul]
city: Seoul
country: Korea, Republic of
facility: Severance Hospital, Yonsei University Health System
state: Seoul-teukbyeolsi [Seoul]
city: Seoul
country: Korea, Republic of
facility: Konkuk University Medical Center
state: Seoul-teukbyeolsi [Seoul]
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center
state: Seoul-teukbyeolsi [Seoul]
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
state: Seoul-teukbyeolsi [Seoul]
city: Seoul
country: Korea, Republic of
facility: The Catholic Univ. of Korea Seoul St. Mary's Hospital
state: Seoul-teukbyeolsi [Seoul]
city: Seoul
country: Korea, Republic of
facility: The Catholic University of Korea, Yeouido St. Mary's Hospital
state: Seoul-teukbyeolsi [Seoul]
city: Seoul
country: Korea, Republic of
facility: Korea University Guro Hospital
state: Seoul-teukbyeolsi [Seoul]
city: Daegu
country: Korea, Republic of
facility: Keimyung University Dongsan Hospital
state: Taegu-Kwangyǒkshi
city: Deagu
country: Korea, Republic of
facility: Kyungpook National University Chilgok Hospital
state: Taegu-Kwangyǒkshi
city: Nam-gu
country: Korea, Republic of
facility: Yeungnam Univeristy Medical Center
state: Taegu-Kwangyǒkshi
city: Harderwijk
country: Netherlands
facility: Ziekenhuis St. Jansdal
state: Gelderland
city: Breda
country: Netherlands
facility: Amphia Ziekenhuis, locatie Breda Molengracht
state: Noord-Brabant
city: Tilburg
country: Netherlands
facility: ETZ Elisabeth
state: Noord-Brabant
city: Amsterdam
country: Netherlands
facility: Nederlands Kanker Instituut - Antoni van Leeuwenhoek (NKI-AVL)
state: Noord-Holland
city: Amsterdam
country: Netherlands
facility: Amsterdam UMC, locatie VUmc
state: Noord-Holland
city: Zwolle
country: Netherlands
facility: Isala, locatie Zwolle
state: Overijssel
city: Utrecht
country: Netherlands
facility: St. Antonius Ziekenhuis, locatie Utrecht
city: Arendal
country: Norway
facility: Sorlandet Sykehus Arendal
state: Aust-Agder
city: Drammen
country: Norway
facility: Drammen Sykehus, Vestre Viken HF
state: Buskerud
city: Bergen
country: Norway
facility: Haukeland Universitetssjukehus
state: Hordaland
city: Gjøvik
country: Norway
facility: Sykehuset Innlandet HF Gjøvik
state: Oppland
city: Oslo
country: Norway
facility: Oslo Universitetssykehus Ullevål
city: Poznan
country: Poland
facility: Wielkopolskie Centrum Pulmonologii i Torakochirurgii
state: Wielkopolskie
city: Szczecin
country: Poland
facility: One Day Med
state: Zachodniopomorskie
city: Kielce
country: Poland
facility: Swietokrzyskie Centrum Onkologii, Samodzielny Publiczny Zaklad Opieki Zdrowotnej
state: Świętokrzyskie
city: Coimbra
country: Portugal
facility: Centro Hospitalar E Universitário De Coimbra
city: Lisboa
country: Portugal
facility: Hospital da Luz Lisboa
city: Porto
country: Portugal
facility: Hospital CUF Porto
city: Porto
country: Portugal
facility: Instituto Português de Oncologia do Porto Francisco Gentil, EPE
city: Bucharest
country: Romania
facility: Lotus-Med
state: București
city: Bucharest
country: Romania
facility: SC Memorial Healthcare International SRL
state: București
city: Ovidiu
country: Romania
facility: Ovidius Clinical Hospital OCH
state: Constanța
city: Cluj
country: Romania
facility: Institutul Oncologic
city: Banska Bystrica
country: Slovakia
facility: Fakultna nemocnica s poliklinikou F.D.Roosevelta Banska Bystrica
state: Banskobystrický Kraj
city: Bratislava
country: Slovakia
facility: Univerzitná nemocnica Bratislava - Nemocnica Ružinov
state: Bratislavský Kraj
city: Kosice
country: Slovakia
facility: Vychodoslovensky Onkologicky ustav a.s.
city: Santiago de Compostela
country: Spain
facility: CHUS - Hospital Clinico Universitario
state: A Coruña [La Coruña]
city: Palma
country: Spain
facility: Hospital Universitari Son Espases
state: Balears [Baleares]
city: Barcelona
country: Spain
facility: Parc de Salut Mar - Hospital del Mar
state: Barcelona [Barcelona]
city: Barcelona
country: Spain
facility: Hospital Universitari Vall d'Hebron
state: Barcelona [Barcelona]
city: Hospitalet
country: Spain
facility: Instituto Catalan de Oncologia - Hospital Duran i Reynals
state: Barcelona [Barcelona]
city: Barcelona
country: Spain
facility: Hospital Clínic de Barcelona
state: Catalunya [Cataluña]
city: Jerez de la Frontera
country: Spain
facility: Hospital Jerez de la Frontera
state: Cádiz
city: Las Palmas de Gran Canaria
country: Spain
facility: Hospital Insular de Gran Canaria
state: Las Palmas
city: Madrid
country: Spain
facility: Hospital General Universitario Gregorio Marañon
state: Madrid, Comunidad De
city: Madrid
country: Spain
facility: Hospital Universitario Ramón y Cajal
state: Madrid, Comunidad De
city: Madrid
country: Spain
facility: Hospital Universitario 12 de Octubre
state: Madrid, Comunidad De
city: Pozuelo de Alarcon
country: Spain
facility: Hospital Universitario Quironsalud Madrid
state: Madrid
city: Pamplona
country: Spain
facility: Complejo Hospitalario de Navarra
state: Navarra
city: Valencia
country: Spain
facility: Hospital Clinico de Valencia
state: Valenciana, Comunitat
city: Badajoz
country: Spain
facility: Hospital Infanta Cristina
city: Málaga
country: Spain
facility: H.R.U Málaga - Hospital General
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen Del Rocio
city: Zaragoza
country: Spain
facility: Hospital Clínico Universitario Lozano Blesa
city: Göteborg
country: Sweden
facility: Sahlgrenska Universitetssjukhuset Östra
state: Västra Götalands Län [se-14]
city: Baden
country: Switzerland
facility: Kantonsspital Baden
city: Fribourg
country: Switzerland
facility: HFR Fribourg - Hôpital Cantonal
city: Zürich
country: Switzerland
facility: UniversitätsSpital Zürich
city: Changhua County
country: Taiwan
facility: Changhua Christian Hospital
state: Changhua
city: Hualien City
country: Taiwan
facility: Hualien Tzu Chi Medical Center
state: Hualien
city: Kaohsiung Niao Sung Dist
country: Taiwan
facility: Chang Gung Memorial Hospital at Kaohsiung
state: Kaohsiung
city: New Taipei City
country: Taiwan
facility: Far Eastern Memorial Hospital
state: New Taipei
city: New Taipei City
country: Taiwan
facility: New Taipei Municipal TuCheng Hospital
state: New Taipei
city: Taichung City
country: Taiwan
facility: Chung Shan Medical University Hospital
state: Taichung
city: Tainan City
country: Taiwan
facility: Chi Mei Medical Center
state: Tainan
city: Tainan City
country: Taiwan
facility: Chi Mei Hospital - Liouying Branch
state: Tainan
city: Taipei City
country: Taiwan
facility: National Taiwan University Cancer Center (NTUCC)
state: Taipei
city: Douliu City
country: Taiwan
facility: National Taiwan University Hospital Yun-Lin Branch Dou-Liou Region
state: Yunlin
city: Chiayi
country: Taiwan
facility: Buddhist Dalin Tzu Chi General Hospital
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Medical University Chung-Ho Memorial Hospital
city: Kaohsiung
country: Taiwan
facility: E-Da hospital
city: Taichung
country: Taiwan
facility: Taichung Veterans General Hospital
city: Tainan
country: Taiwan
facility: National Cheng Kung University Hospital
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hospital
city: Taoyuan
country: Taiwan
facility: Chang Gung Medical Foundation-Linkou Branch
city: Pendik
country: Turkey
facility: Marmara Universitesi Pendik Egitim Arastirma Hastanesi
state: İstanbul
city: Adapazari
country: Turkey
facility: Sakarya University School of Medicine
state: Sakarya
city: Adana
country: Turkey
facility: Baskent University Dr. Turgut Noyan Research and Training Center
city: Adana
country: Turkey
facility: Adana City Hospital
city: Antalya
country: Turkey
facility: Antalya Egitim ve Arastırma Hastanesi
city: Edirne
country: Turkey
facility: Trakya University
city: Gaziantep
country: Turkey
facility: Gaziantep Universitesi Sahinbey Arastirma ve Uygulama Hastanesi
city: Istanbul
country: Turkey
facility: İ.A.Ü VM Medical Park Florya Hastanesi
city: Izmir
country: Turkey
facility: Izmir Atatürk Training and Research Hospital
city: Samsun
country: Turkey
facility: Samsun Medical Park Hastanesi
city: East Sussex
country: United Kingdom
facility: University Hospitals Sussex NHS Foundation Trust
state: Brighton And Hove
city: Torquay
country: United Kingdom
facility: Torbay Hospital
state: Devon
city: Huddersfield
country: United Kingdom
facility: Huddersfield Royal Infirmary
state: England
city: London
country: United Kingdom
facility: Royal Marsden Hospital (Chelsea)
state: Kensington And Chelsea
city: London
country: United Kingdom
facility: Royal Marsden Hospital (Sutton)
state: Sutton
city: Birmingham
country: United Kingdom
facility: Heartlands Hospital
city: Manchester
country: United Kingdom
facility: The Christie NHS Foundation Trust
Study officials:
affiliation: Eli Lilly and Company
name: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM to 5 PM Eastern Time (UTC/GMT - 5 hours, EST)
role: STUDY_DIRECTOR
References: