louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06579651: Nailfold Capillaroscopic Pattern Changes and Its Correlation with Interstitial Lung Disease (ILD) in Systemic Sclerosis (SSc) Patients.
Official title: Nailfold Capillaroscopic Pattern Changes and Its Correlation with Interstitial Lung Disease (ILD) in Systemic Sclerosis (SSc) Patients.
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Systemic Sclerosis (SSc)
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2024-08-30
Enrollment: 45
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: cross sectional

Brief summary: Detection of different pattern of nail fold capillary changes in SSc patients. Correlation of nail fold capillary changes in SSc patients with ILD.

Detailed description: SSc is a connective tissue disease characterized by early microvascular damage and dysfunction and immune system activation, as well as progressive fibrosis in the skin and internal organs.

Nailfold videocapillaroscopy (NVC) is the validated technique to assess SSc microvascular damage and is useful for the early diagnosis and follow-up of SSc micro- angiopathy.

Several studies have demonstrated correlations between microvascular damage extent and the severity of internal organ involvement, showing that NVC abnormalities correlate with disease activity and severity and may be also predictive for disease worsening. Furthermore, successful treatments have been shown to reduce NVC abnormalities in SSc cases, and these findings support the importance of NVC in monitoring SSc patients and also suggest its possible role as an outcome measure for microangiopathy in clinical trials.

Three different NVC patterns of microvascular damage have been described (\&#34;early\&#34; , \&#34;active\&#34; , \&#34;late\&#34; ).

Eligibility criteria: Inclusion Criteria:

* Adult SSc Patients

Exclusion Criteria:

- 1-SSc patients aged less than 18 years old. 2-Individuals with other autoimmune diseases (rheumatoid arthritis, dermatomyositis, connective tissue disease).

3-Congestive heart failure and presence of clubbing. 4-history of smoking. 5-Patients unable to co-operate for nail fold capillaroscopic examination.

Primary outcomes:
measure: Nail fold capillary pattern changes in SSc patients
timeFrame: baseline
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT00803751: A Comparison of the Infant Truview EVO2 Video Laryngoscope and the Macintosh Laryngoscope in Pediatric Patients
Official title: A Comparison of the Infant Truview EVO2 Video Laryngoscope and the Macintosh Laryngoscope in Pediatric Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Laryngoscopy
Keywords: Laryngoscopy [E04.580.373]
Lead sponsor: The University of Texas Health Science Center, Houston
Sponsor class: OTHER
First posted: 2008-12-08
Enrollment: 60
Sex: ALL
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: This study is intended to examine the effectiveness of a new type of laryngoscope, the Truview EVO2, in an infant patient population. They device will be tested against the current clinical standard, the Macintosh laryngoscope, in patients undergoing surgery at our hospital in terms of ease of use, view obtained of the vocal cords, and ability to place an endotracheal tube.


Eligibility criteria: Inclusion Criteria:

1. Age less than one year
2. Requiring general anesthesia and orotracheal intubation
3. Weight less than 10 kg
4. ASA class 1-3

Exclusion Criteria:

1. Documented difficult airway
2. Facial deformities

Primary outcomes:
measure: Quality of Laryngeal View Obtained on Comarck Lehane Classification
timeFrame: during laryngoscopy prior to intubation. Few minutes before intubation
measure: Number of Intubation Attempts
timeFrame: during intubation prior to surgery
measure: Quality of Laryngeal View Obtained With 2nd Laryngoscopy
timeFrame: during laryngoscopy prior to intubation (few minutes prior to intubation)
Secondary outcomes:
measure: Time Taken for Intubation
timeFrame: throughout the intubation procedure
measure: POGO Score With 1st Laryngoscopy
timeFrame: Before patient is intubated (few minutes before intubation)
measure: POGO Score With 2nd Laryngoscopy
timeFrame: Before patient is intubated
Other outcomes:
Locations:
city: Houston
country: United States
facility: Memorial Hermann Hospital - Texas Medical Center
state: Texas
Study officials:
affiliation: The University of Texas Health Science Center, Houston
name: Maria Matuszczak, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00539851: Risk Factors for Diabetes After Stem Cell Transplantation
Official title: Risk Factors for Developing Diabetes Mellitus After Allogenic Stem Cell Transplantation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Diabetes Mellitus
Keywords: Allogenic Stem Cell Transplantation
Diabetes Mellitus
Lead sponsor: Vanderbilt University
Sponsor class: OTHER
Collaborators: name: Sanofi
First posted: 2007-10-05
Enrollment: 87
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The patients will be enrolled through the Endocrinology, Hematology and Stem Cell Transplantation Clinics at Vanderbilt University Medical Center.

Brief summary: This study is proposed to investigate the incidence of Post Transplant Diabetes Mellitus (PTDM) as well as associated risk factors for the development of PTDM in patients undergoing allogenic stem cell transplantation.

Detailed description: Allogenic stem cell transplantation from related or unrelated donors has been used successfully to cure patients with a variety of hematological malignancies. Graft-versus-host disease (GVHD) is an alloreactive immune phenomenon, where the activated donor T cells recognizes the recipient as being foreign and effects a cytotoxic response. GVHD occurring in the first 100 days after transplantation is termed acute GVHD and is characterized by hepatitis, dermatitis, and enteritis.

High dose corticosteroids remain one of the cornerstone therapies to treat acute GVHD. However, an association between corticosteroid therapy and the development of diabetes mellitus after solid organ transplantation has become widely recognized. Similarly, post transplant diabetes mellitus (PTDM) has been increasingly noted in the allogenic stem cell transplant population, however, to date, no systematic study has been completed to identify the incidence of PTDM and associated risk factors. We propose to investigate the incidence of PTDM as well as associated risk factors for the development of PTDM in patients undergoing allogenic stem cell transplantation.

Eligibility criteria: Inclusion Criteria:

* 18 - 65 years or age
* Fulfills institutional criteria for and is scheduled to undergo an allogenic stem cell transplantation at VUMC

Exclusion Criteria:

* Younger than 18 years or older than 65 years
* Pre-existing diabetes mellitus
* Positive pregnancy test
* Unable to complete the conditioning regimen prior to stem cell transplantation
* Unable to give informed consent

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Vanderbilt University Medical Center
name: Shubhada Jagasia, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00328354: Mammography SPECT With Rotating Slant Hole Collimator
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Breast Cancer
Lead sponsor: Johns Hopkins University
Sponsor class: OTHER
First posted: 2006-05-19
Enrollment: 0
Sex: FEMALE
Minimum age (years): 35
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Women seen at Johns Hopkins Avon Division of Breast Imaging who have been diagnosed with breast cancer.

Brief summary: The goal is to conduct a pilot study to determine the feasibility of the clinical use of RMSSH SPECT imaging technology for breast imaging and to develop a standardized clinical protocol.

Detailed description: The goal of this protocol is to develop and evaluate a novel SPECT imaging technique for imaging the breast using rotating multi-segment slant-hole (RMSSH) collimators. The motivation is the requirement of a low cost RMSSH collimator and a conventional Large-Field-Of-View (LFOV) camera. It is believed that RMSSH SPECT is particularly suitable for applications in breast imaging.

Eligibility criteria: Inclusion Criteria:

* Women seen at Johns Hopkins Avon Division of Breast Imaging who have been diagnosed with breast cancer.

Exclusion Criteria:

* Pregnant (or possibly pregnant)
* Lactating
* Unable to give consent
* Weights over 300 pounds
* Women who have already undergone definitive surgical treatment to their breast for breast cancer will not be eligible.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Baltimore
country: United States
facility: Johns Hopkins Outpatient Center
state: Maryland
Study officials:
affiliation: Johns Hopkins University
name: Benjamin Tsui, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06539754: Patient Satisfaction During Cesarean Delivery
Official title: Patient Satisfaction of the Environment During Cesarean Delivery
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Patient Satisfaction
Keywords: Cesarean delivery
Lead sponsor: Geisinger Clinic
Sponsor class: OTHER
First posted: 2024-08-06
Enrollment: 48
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The goal of this interventional study is to determine whether listening to music during cesarean delivery increases the participants satisfaction. Participants and their support person will be asked to fill out a short survey and mark their satisfaction on a visual analog scale. Vital signs will be recorded during their procedure.

Detailed description: Currently, our institution does not routinely offer music during cesarean delivery. The goal of this study would be to determine whether music improves patient satisfaction. Also, the study would examine support person satisfaction and changes in maternal vital signs from prior to entering the operating room as compared to prior to exiting the operating room in a sample of patients. If positive satisfaction results are noted in those randomized to the music arm, this would be a low-cost intervention that providers could utilize to increase patient satisfaction during surgery.

This will be a prospective randomized controlled trial to determine whether music being played in the operating room can impact the experience for the patient. Subjects will be randomized via central computer-generated randomization 1:1 to either have music played during their procedure or no music played during their procedure. A per protocol analysis will be performed.

Eligibility criteria: Inclusion Criteria:

* Singleton pregnancy
* Second or third cesarean delivery
* Scheduled cesarean delivery at Geisinger Medical Center
* Able and willing to provide consent
* English speaking
* Greater than or equal to 37 weeks' gestation

Exclusion Criteria:

* Fetal anomaly
* Multifetal gestation
* Hearing loss requiring a sign interpreter or hearing aids
* Planned general anesthesia
* Intrauterine fetal demise
* Participants that present in labor or require urgent/emergent cesarean delivery

Primary outcomes:
measure: Participant satisfaction
timeFrame: This is collected during the study duration, on average 6 hours.
Secondary outcomes:
measure: Support person satisfaction
timeFrame: This is collected through the duration of the study, on average 6 hours,
measure: Heart rate
timeFrame: This will be collected during the study duration, an average 6 hours.
measure: Music and satisfaction
timeFrame: This is collected during the study duration, on average 6 hours.
measure: Blood pressure
timeFrame: This will be collected during the study duration, an average 6 hours.
Other outcomes:
Locations:
city: Danville
country: United States
facility: Geisinger
state: Pennsylvania
Study officials:
affiliation: Geisinger Clinic
name: Awathif D Mackeen, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04862754: Effect of Interval Training on Arterial Stiffness in Women With Hypertension
Official title: Effect of Interval Training on Arterial Stiffness in Women With Hypertension
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Arterial Stiffness
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2021-04-28
Enrollment: 50
Sex: FEMALE
Minimum age (years): 40
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: this study is aiming to assess the chronic effect of the interval training program on arterial stiffness in women with hypertension


Eligibility criteria: Inclusion Criteria:

* physically inactive
* BMI 30-40
* Stage 1 and 2 hypertension
* Elevated BP as systolic BP ≥130 mm Hg and/or diastolic BP ≥85 mm Hg measured at the brachial artery.

Exclusion Criteria:

* Medications known to affect weight or appetite
* Any disease associated with exercise intolerance.
* Women were taking hormone replacement therapy

Primary outcomes:
measure: Central arterial stiffness measurements (Pulse Wave Velocity [PWV], augmentation index )
timeFrame: two months
Secondary outcomes:
measure: blood lipid profile
timeFrame: two months
measure: interleukin 6
timeFrame: two months
measure: blood pressure (systolic and diastolic)
timeFrame: two months
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty of physical therapy
Study officials:
References:
Clinical trial NCT06084754: Effect of Pulsed Electromagnetic Field Stimulation on Localized Pediatric Osteomyelitis
Official title: Effect of Pulsed Electromagnetic Field Stimulation on Localized Pediatric Osteomyelitis : Randomized Control Trail Study
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Osteomyelitis
Keywords: Osteomyelitis
Pulsed Electromagnetic Field
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2023-10-16
Enrollment: 20
Sex: ALL
Minimum age (years): 5
Maximum age (years): 16
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will be applied to evaluate effect of pulsed electromagnetic field on pediatric localized osteomyelitis.

Detailed description: Twenty (11 girls, 9 boys) patients will participate in this study. Their ages ranged from 5 to 16 years. They will randomly divide into two groups. Group A ( study group) will receive pulsed electromagnetic field in addition to medical treatment three times per week for two months , Group B(control group ) will receive medical treatment only.

Eligibility criteria: Inclusion Criteria:

1. All patients suffering from localized osteomyelitis in one or both lower limbs
2. All patients will be assessed by a physician before starting the study procedures.

Exclusion Criteria:

1. Patients with immune disorders .
2. Patients who suffer from any systemic diseases that may interfere with the objectives of the study.

Primary outcomes:
measure: Changing of osteomyelitis signs
timeFrame: pre treatment and post two months of treatment
Secondary outcomes:
Other outcomes:
Locations:
city: Giza
country: Egypt
facility: Physical Therapy Cairo University
Study officials:
affiliation: physical therapy, Cairo university
name: Nessrien A. AbdelRashid, Ass.professor
role: STUDY_DIRECTOR
References:
Clinical trial NCT05307354: The Effectiveness of Tibial Nerve Mobilization in Patients With Tarsal Tunnel Syndrome
Official title: The Effectiveness of Tibial Nerve Mobilization in Patients With Tarsal Tunnel Syndrome
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Nerve Compression Syndromes
Neuropathic Pain
Lead sponsor: Kutahya Health Sciences University
Sponsor class: OTHER
First posted: 2022-04-01
Enrollment: 40
Sex: ALL
Minimum age (years): 20
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: TREATMENT

Brief summary: This randomized, clinical, single-blinded, controlledstudywasinitiallyplannedtoinclude 35 patients diagnosed with tarsal tunnel who applied to Kütahya Health Sciences University, Evliya Çelebi Training and Research Hospital, Physical Medicine and Rehabilitation outpatient clinic.Patients aged 20-55 years who were diagnosed with tarsal tunnel syndrome by electromyography (EMG) in the last 6 months were included in the study. The patients were randomized into two groups using the computer-assisted randomization method. Tibial nerve mobilization and foot-ankle range of motion exercises will be given to the study group, and only foot-ankle joint range of motion exercises will be given to the control group. All the patients were evaluated with the Visual Analog Scale (VAS), Foot Functional Index (FFI), Neuropathic Pain QuestionnaireN (NPQ) and Tibial Nerve ultrasonography before the intervention and at the fourth week of intervention.


Eligibility criteria: Inclusion Criteria:

* Patients aged 20-55 years who were diagnosed with tarsal tunnel syndrome by electromyography (EMG) in the last 6 months were included in the study.

Exclusion Criteria:

* Have a systemic inflammatory disease
* Presence of a cognitive disorder, receiving psychotherapy or any psychiatric treatment, disease affecting the central nervous system
* Being illiterate
* Having hearing, vision problems
* History of foot and ankle surgery
* Any pathology that may cause pain in the foot joint diagnosed on physical examination
* Inadequate function of any extremity that would prevent exercise
* The presence of a balance disorder or a disease that can disrupt the balance
* Diagnosis of advanced cardiac or lung disease for which exercise would be contraindicated

Primary outcomes:
measure: Visual analogue scale
timeFrame: Change from Baseline at 4th weeks
measure: Evaluation of the tibial nerve with ultrasonography
timeFrame: Change from Baseline at 4th weeks
measure: Tinel's Sign
timeFrame: Change from Baseline at 4th weeks
Secondary outcomes:
measure: Foot Function Index
timeFrame: Change from Baseline at 4th weeks
measure: Neuropathic pain questionnaire
timeFrame: Change from Baseline at 4th weeks
Other outcomes:
Locations:
city: Kütahya
country: Turkey
facility: Kutahya Health Sciences University
Study officials:
affiliation: Kutahya Health Sciences University
name: Merve Akdeniz LEBLEBİCİER, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01798654: EUS-FNA for Patients With Antithrombotic Agents
Official title: Safety of Endoscopic Ultrasound-guided Fine Needle Aspiration for Patients With Antithrombotic Agents
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Solid Tumor
Lead sponsor: Hokkaido Pancreatobiliary Endoscopic Intervention Study Group
Sponsor class: NETWORK
Collaborators: name: Hokkaido University Hospital
First posted: 2013-02-26
Enrollment: 84
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: In hospital

Brief summary: The purpose of this study to evaluate a safety of endoscopic ultrasound-guided fine needle aspiration (EUS-FNA) for patients with antithrombotic agents.


Eligibility criteria: Inclusion Criteria:

* Undergo EUS-FNA
* take antithrombotic agents

Exclusion Criteria:

* Cystic lesion

Primary outcomes:
measure: Patients who suffered bleeding complication
timeFrame: One week
Secondary outcomes:
Other outcomes:
Locations:
city: Sapporo
country: Japan
facility: Hokkaido University Graduate School of Medicine
Study officials:
References:
Clinical trial NCT03636854: Quadriceps Concentric vs Eccentric
Official title: Effect of Different Izotonic Quadriceps Exercise Training on Muscle Strength, Muscle Thickness and Balance in Healthy Individuals
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Keywords: Muscle thickness
muscle strength
hop Test
Balance
performance
Lead sponsor: Dokuz Eylul University
Sponsor class: OTHER
First posted: 2018-08-17
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 25
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of the study is to compare the effects of concentric and eccentric exercises on muscle strength, muscle thickness and balance in healthy Individuals. Participants will randomly be divided into 2 groups: Concentric exercise (CE) group, eccentric exercise (EE) group. Concentric exercise group will be doing 2 concentric exercises and eccentric exercise group will be doing 2 eccentric exercise for 8 weeks. The evaluations will be repeated after 8 weeks of training to reveal the effects of concentric and eccentric exercises.


Eligibility criteria: Inclusion Criteria:

* Age between 18-25
* Healthy individuals
* Able to read, write and understand Turkish
* Willing and able to attend study

Exclusion Criteria:

* Any neurological, musculoskeletal or vascular disease in any of the lower extremity
* Having lower extremity musculoskeletal pain
* Previous history of surgery in any of the lower extremity
* Mental and cognitive disorders that would seriously affect cooperation

Primary outcomes:
measure: Change in muscle thickness
timeFrame: Before training and after 8 weeks of training
Secondary outcomes:
measure: Change in muscle strength
timeFrame: Before training and after 8 weeks of training
measure: Change in balance
timeFrame: Before training and after 8 weeks of training
measure: Change in function
timeFrame: Before training and after 8 weeks of training
Other outcomes:
Locations:
city: İzmir
country: Turkey
facility: Dokuz Eylul University
Study officials:
References: