Clinical trial NCT00878709: Study Evaluating The Effects Of Neratinib After Adjuvant Trastuzumab In Women With Early Stage Breast Cancer
Official title: A Randomized, Double-Blind, Placebo-Controlled Trial Of Neratinib (HKI-272) After Trastuzumab In Women With Early-Stage HER-2/Neu Overexpressed/Amplified Breast Cancer
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Breast Cancer
Keywords: HER-2/erbB-2 positive breast cancer
breast cancer
adjuvant therapy
neratinib
HKI-272
Nerlynx
PB-272
Lead sponsor: Puma Biotechnology, Inc.
Sponsor class: INDUSTRY
First posted: 2009-04-09
Enrollment: 2840
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to investigate whether neratinib can further reduce the risk of recurrence from previously diagnosed HER-2 positive breast cancer after adjuvant treatment with trastuzumab.


Eligibility criteria: Inclusion Criteria:

* Stage II through IIIC HER-2/erbB-2 positive breast cancer with node positive disease.
* Been treated for early breast cancer with standard of care duration of trastuzumab.
* Could have been treated neoadjuvantly but have not reached pathologic complete response.

Exclusion Criteria:

* Positive clinical and radiologic assessments for local or regional recurrence of disease at the time of study entry.
* History of heart disease.
* Corrected QT (QTc) interval \>0.45 seconds
* History of gastrointestinal disease with diarrhea as the major symptom.

Primary outcomes:
measure: Invasive Disease-free Survival (iDFS) in Neratinib Arm Compared to Placebo Arm at Year 2
timeFrame: From randomization until time of event up to 2 years
measure: Kaplan-Meier Estimates of Invasive Disease-free Survival (iDFS) at Year 2 by Treatment Arms
timeFrame: From randomization until time of event up to 2 years
Secondary outcomes:
measure: Overall Survival (OS)
timeFrame: Randomization until death due to any cause (up to 119 Months)
measure: Disease-free Survival Including Ductal Carcinoma in Situ (DFS-DCIS) in Neratinib Arm Compared to Placebo Arm at Year 2
timeFrame: From randomization until time of event up to 2 years
measure: Kaplan-Meier Estimates of Disease-free Survival Including Ductal Carcinoma in Situ (DFS-DCIS) at Year 2 by Treatment Arms
timeFrame: From randomization until time of event up to 2 years
measure: Distant Disease-free Survival (DDFS) in Neratinib Arm Compared to Placebo Arm at Year 2
timeFrame: From randomization until time of event up to 2 years
measure: Kaplan-Meier Estimates of Distant Disease-free Survival (DDFS) at Year 2 by Treatment Arms
timeFrame: From randomization until time of event up to 2 years
measure: Percentage of Participants With Time to Distant Recurrence (TTDR) Event in Neratinib Arm Compared to Placebo Arm at Year 2
timeFrame: From randomization until time of event up to 2 years
measure: Kaplan-Meier Estimates of Time to Distant Recurrence (TTDR) Survival at Year 2 by Treatment Arms
timeFrame: From randomization until time of event up to 2 years
measure: Central Nervous System Recurrence in Neratinib Arm Compared to Placebo Arm at Year 2
timeFrame: From randomization until time of event up to 2 years
measure: Cumulative Incidence of Central Nervous System Recurrence (CNS) at Year 2
timeFrame: From randomization until time of event up to 2 years
Other outcomes:
measure: Invasive Disease-free Survival (iDFS) in Neratinib Arm Compared to Placebo Arm at Year 5
timeFrame: From randomization until time of event up to 5 years
measure: Kaplan-Meier Estimates of Invasive Disease-free Survival (iDFS) at Year 5 by Treatment Arms
timeFrame: From randomization until time of event up to 5 years
measure: Disease-free Survival Including Ductal Carcinoma in Situ (DFS-DCIS) in Neratinib Arm Compared to Placebo Arm at Year 5
timeFrame: From randomization until time of event up to 5 years
measure: Distant Disease-free Survival (DDFS) in Neratinib Arm Compared to Placebo Arm at Year 5
timeFrame: From randomization until time of event up to 5 years
measure: Percentage of Participants With Time to Distant Recurrence (TTDR) Event in Neratinib Arm Compared to Placebo Arm at Year 5
timeFrame: From randomization until time of event up to 5 years
measure: Cumulative Incidence of Central Nervous System Recurrence (CNS) at Year 5
timeFrame: From randomization until time of event up to 5 years
Locations:
city: Anniston
country: United States
facility: Anniston Oncology
state: Alabama
city: Birmingham
country: United States
facility: Birmingham Hematology and Oncology Associates, LLC
state: Alabama
city: Phoenix
country: United States
facility: Arizona Oncology Associates, PC - HAL
state: Arizona
city: Sedona
country: United States
facility: Arizona Oncology Associates, PC - NAHOA
state: Arizona
city: Tucson
country: United States
facility: Arizona Oncology Associates
state: Arizona
city: Tucson
country: United States
facility: Arizona Cancer Center
state: Arizona
city: Jonesboro
country: United States
facility: Northeast Arkansas Clinic
state: Arkansas
city: Beverly Hills
country: United States
facility: Cedars-Sinai Medical Group
state: California
city: Gilroy
country: United States
facility: Ronald Yanagihara, M.D.
state: California
city: Glendale
country: United States
facility: Glendale Adventist Medical Center Cancer Services
state: California
city: Greenbrae
country: United States
facility: California Cancer Care
state: California
city: Highland
country: United States
facility: Beaver Medical Group, L.P.
state: California
city: Long Beach
country: United States
facility: Breastlink Medical Group
state: California
city: Long Beach
country: United States
facility: Long Beach Memorial Medical Center
state: California
city: Mission Hills
country: United States
facility: Facey Medical Group
state: California
city: Newport Beach
country: United States
facility: Gynecologic Oncology Associates
state: California
city: Oxnard
country: United States
facility: Ventura County Hematology-Oncology Specialists
state: California
city: Rancho Mirage
country: United States
facility: Desert Hematology Oncology Medical Group, Inc
state: California
city: San Francisco
country: United States
facility: Helen Diller Family University of California San Francisco Comprehensive Cancer Center
state: California
city: San Francisco
country: United States
facility: San Francisco Oncology Associates
state: California
city: Santa Rosa
country: United States
facility: Redwood Regional Medical Group
state: California
city: Soquel
country: United States
facility: The Cancer Prevention and Treatment Center
state: California
city: Southington
country: United States
facility: Cancer Center of Central Connecticut
state: Connecticut
city: Stamford
country: United States
facility: Hematology Oncology, PC
state: Connecticut
city: Torrington
country: United States
facility: Connecticut Oncology and Hematology
state: Connecticut
city: Washington
country: United States
facility: Washington Cancer Institute at Washington Hospital Center
state: District of Columbia
city: Aventura
country: United States
facility: Innovative Medical Research of South Florida, Inc.
state: Florida
city: Boynton Beach
country: United States
facility: University Cancer Institute, LLC
state: Florida
city: Deerfield Beach
country: United States
facility: North Broward Medical Center
state: Florida
city: Fort Lauderdale
country: United States
facility: Broward General Medical Center
state: Florida
city: Gainesville
country: United States
facility: Florida Cancer Specialists and Research Institute
state: Florida
city: Lakeland
country: United States
facility: Lakeland Regional Cancer Center
state: Florida
city: Loxahatchee Groves
country: United States
facility: Hematology Oncology Associates
state: Florida
city: Ocala
country: United States
facility: Florida Cancer Affiliates - Ocala
state: Florida
city: Orange City
country: United States
facility: Mid-Florida Hematology & Oncology Centers, PA
state: Florida
city: Orlando
country: United States
facility: Cancer Centers of Florida
state: Florida
city: Orlando
country: United States
facility: M.D. Anderson Cancer Center Orlando
state: Florida
city: Plantation
country: United States
facility: Florida Cancer Research Institute
state: Florida
city: Port Saint Lucie
country: United States
facility: Hematology Oncology Associates of Treasure Coast
state: Florida
city: Saint Petersburg
country: United States
facility: Florida Cancer Specialists, P.L.
state: Florida
city: Tamarac
country: United States
facility: Oncology and Hematology of West Broward
state: Florida
city: Zephyrhills
country: United States
facility: Florida Medical Clinic, P.A.
state: Florida
city: Albany
country: United States
facility: Phoebe Cancer Center
state: Georgia
city: Atlanta
country: United States
facility: Piedmont Cancer Institute
state: Georgia
city: Augusta
country: United States
facility: Augusta Oncology Associates (ACORN), P.C.
state: Georgia
city: Fort Gordon
country: United States
facility: Dwight David Eisenhower Army Medical Center
state: Georgia
city: Honolulu
country: United States
facility: Straub Clinic & Hospital
state: Hawaii
city: Pocatello
country: United States
facility: Portneuf Medical Center
state: Idaho
city: Chicago
country: United States
facility: Rush University Medical Center
state: Illinois
city: Decatur
country: United States
facility: Cancer Care Specialists of Illinois, Decatur Memorial Hospital Clinical Research
state: Illinois
city: Joliet
country: United States
facility: Midwest Center for Hematology/Oncology
state: Illinois
city: Moline
country: United States
facility: Medical Arts Associates, Ltd
state: Illinois
city: Niles
country: United States
facility: Advocate Medical Group
state: Illinois
city: Niles
country: United States
facility: Cancer Care & Hematology Specialists of Chicagoland
state: Illinois
city: Quincy
country: United States
facility: Quincy Medical Group, Cancer Center at Blessing Hospital
state: Illinois
city: Skokie
country: United States
facility: North Shore Cancer Research Associates
state: Illinois
city: Skokie
country: United States
facility: Orchard Healthcare Research, Inc.
state: Illinois
city: Skokie
country: United States
facility: Orchard Research, LLC
state: Illinois
city: Springfield
country: United States
facility: Simmons Cancer Institute
state: Illinois
city: Springfield
country: United States
facility: Springfield Clinic, LLP
state: Illinois
city: Zion
country: United States
facility: Midwestern Regional Medical Center
state: Illinois
city: Indianapolis
country: United States
facility: Central Indiana Cancer Centers
state: Indiana
city: Indianapolis
country: United States
facility: Hematology Oncology of Indiana
state: Indiana
city: Munster
country: United States
facility: Community Hospital
state: Indiana
city: Ashland
country: United States
facility: Ashland-Bellefonte Cancer Center
state: Kentucky
city: Paducah
country: United States
facility: Purchase Cancer Group
state: Kentucky
city: Baton Rouge
country: United States
facility: Hematology-Oncology Clinic
state: Louisiana
city: Marrero
country: United States
facility: Crescent City Research Consortium, LLC
state: Louisiana
city: Lewiston
country: United States
facility: Central Maine Healthcare Corp
state: Maine
city: Portland
country: United States
facility: Mercy Hospital Oncology/Hematology Center
state: Maine
city: York
country: United States
facility: York Hospital Oncology Treatment Center
state: Maine
city: Baltimore
country: United States
facility: Medical Oncology & Hematology Mercy Medical Center
state: Maryland
city: Baltimore
country: United States
facility: Harry and Jeanette Weinberg Cancer Center
state: Maryland
city: Westminster
country: United States
facility: Alliance Hematology Oncology, PA Carroll County Cancer Center
state: Maryland
city: Boston
country: United States
facility: Massachusetts General Hospital
state: Massachusetts
city: Boston
country: United States
facility: Massachusetts General Hospital - Gillette Center
state: Massachusetts
city: Worcester
country: United States
facility: University of Massachusetts Memorial Medical Center
state: Massachusetts
city: Detroit
country: United States
facility: Barbara Ann Karmanos Cancer Institute
state: Michigan
city: Grand Rapids
country: United States
facility: Cancer and Hematology Centers of Western Michigan
state: Michigan
city: Grand Rapids
country: United States
facility: Medical Specialty Associates
state: Michigan
city: Petoskey
country: United States
facility: Northern Michigan Hematology/Oncology
state: Michigan
city: Minneapolis
country: United States
facility: Minnesota Oncology Hematology, PA
state: Minnesota
city: Saint Louis Park
country: United States
facility: Park Nicollet Institute
state: Minnesota
city: Tupelo
country: United States
facility: North Mississippi Hematology and Oncology Associates, Ltd.
state: Mississippi
city: Jefferson City
country: United States
facility: Capitol Comprehensive Cancer Care Clinic
state: Missouri
city: Saint Joseph
country: United States
facility: St. Joseph's Oncology
state: Missouri
city: Saint Louis
country: United States
facility: Washington University School of Medicine Siteman Cancer Center
state: Missouri
city: Springfield
country: United States
facility: Mercy Medical Research Institute
state: Missouri
city: Missoula
country: United States
facility: Montana Cancer Specialists
state: Montana
city: Lincoln
country: United States
facility: Southeast Nebraska Hematology & Oncology Consultants, PC
state: Nebraska
city: North Platte
country: United States
facility: Great Plains Regional Medical Center
state: Nebraska
city: Cherry Hill
country: United States
facility: The Center for Cancer and Hematologic Disease
state: New Jersey
city: Elizabeth
country: United States
facility: Trinitas Comprehensive Cancer Center
state: New Jersey
city: Livingston
country: United States
facility: Saint Barnabas Health Care System
state: New Jersey
city: Morristown
country: United States
facility: Summit Medical Group
state: New Jersey
city: Mountain Lakes
country: United States
facility: Oncology and Hematology Specialist
state: New Jersey
city: Neptune
country: United States
facility: Jersey Shore University Medical Center
state: New Jersey
city: Paramus
country: United States
facility: The Valley Hospital, Luckow Pavilion
state: New Jersey
city: Voorhees
country: United States
facility: Cooper University Hospital
state: New Jersey
city: Bronx
country: United States
facility: Eastchester Center for Cancer Care
state: New York
city: Lake Success
country: United States
facility: ProHealth Care Associates
state: New York
city: New York
country: United States
facility: NYU Clinical Cancer Center
state: New York
city: New York
country: United States
facility: Columbia University Medical Center, Herbert Irving Comprehensive Cancer Center
state: New York
city: Concord
country: United States
facility: NorthEast Oncology Associates Carolinas Medical Center NorthEast
state: North Carolina
city: Durham
country: United States
facility: Duke University Medical Center Medical Oncology
state: North Carolina
city: Raleigh
country: United States
facility: Raleigh Hematology Oncology Associates Cancer Centers of North Carolina
state: North Carolina
city: Wilmington
country: United States
facility: Hanover Medical Specialists, PA
state: North Carolina
city: Bismarck
country: United States
facility: Mid Dakota Clinic, PC
state: North Dakota
city: Cincinnati
country: United States
facility: The Christ Hospital Cancer Center
state: Ohio
city: Cincinnati
country: United States
facility: University of Cincinnati
state: Ohio
city: Cleveland
country: United States
facility: University Hospitals, Cleveland Medical Center
state: Ohio
city: Cleveland
country: United States
facility: MetroHealth Medical Center
state: Ohio
city: Middletown
country: United States
facility: Signal Point Hematology/Oncology, Inc.
state: Ohio
city: Oklahoma City
country: United States
facility: Mercy Physicians of Oklahoma
state: Oklahoma
city: Bend
country: United States
facility: Bend Memorial Clinic
state: Oregon
city: Corvallis
country: United States
facility: Samaritan Hematology & Oncology Consultants
state: Oregon
city: Portland
country: United States
facility: Northwest Cancer Specialist, P.C.
state: Oregon
city: Portland
country: United States
facility: Providence Cancer Center Oncology and Hematology Care - Westside
state: Oregon
city: Portland
country: United States
facility: Kaiser Permanente Northwest Region Oncology Hematology
state: Oregon
city: Portland
country: United States
facility: Oregon Health and Science University
state: Oregon
city: Springfield
country: United States
facility: Willamette Valley Cancer Institute and Research Center
state: Oregon
city: Bethlehem
country: United States
facility: Oncology-Hematology of Lehigh Valley, PC
state: Pennsylvania
city: Gettysburg
country: United States
facility: Gettysburg Cancer Center
state: Pennsylvania
city: Harrisburg
country: United States
facility: Pinnacle Health Cancer Center Community Campus
state: Pennsylvania
city: Monongahela
country: United States
facility: Sweeney-Melenyser Pavillion
state: Pennsylvania
city: Philadelphia
country: United States
facility: Perelman Center for Advanced Medicine
state: Pennsylvania
city: Philadelphia
country: United States
facility: Thomas Jefferson University
state: Pennsylvania
city: Philadelphia
country: United States
facility: Temple University Hospital
state: Pennsylvania
city: Philadelphia
country: United States
facility: Albert Einstein Cancer Center
state: Pennsylvania
city: Sayre
country: United States
facility: Guthrie Clinic, Limited
state: Pennsylvania
city: Willow Grove
country: United States
facility: Abington Hematology Oncology Associates, Inc
state: Pennsylvania
city: Pawtucket
country: United States
facility: Pawtuket Memorial Hospital
state: Rhode Island
city: Charleston
country: United States
facility: Charleston Hematology Oncology Associates, PA
state: South Carolina
city: Charleston
country: United States
facility: Medical University of South Carolina Hollings Cancer Center
state: South Carolina
city: Columbia
country: United States
facility: Francisco Gonzalez MD PA
state: South Carolina
city: Florence
country: United States
facility: McLeod Oncology and Hematology Associates
state: South Carolina
city: Hilton Head Island
country: United States
facility: South Carolina Cancer Specialists
state: South Carolina
city: Sumter
country: United States
facility: Santee Hematology Oncology
state: South Carolina
city: Sioux Falls
country: United States
facility: Avera Medical Oncology and Hematology - Avera Cancer Institute
state: South Dakota
city: Chattanooga
country: United States
facility: University Hematology/Oncology Associates PLLC
state: Tennessee
city: Cookeville
country: United States
facility: Cookeville Regional Cancer Center
state: Tennessee
city: Germantown
country: United States
facility: The Jones Clinic, PC
state: Tennessee
city: Knoxville
country: United States
facility: Thompson Cancer Survival Center
state: Tennessee
city: Nashville
country: United States
facility: Nashville Breast Center
state: Tennessee
city: Nashville
country: United States
facility: Vanderbilt-Ingram Cancer Center
state: Tennessee
city: Austin
country: United States
facility: Texas Oncology, P.A.
state: Texas
city: Bedford
country: United States
facility: Texas Oncology, P.A.
state: Texas
city: Corpus Christi
country: United States
facility: Coastal Bend Cancer Center
state: Texas
city: Corpus Christi
country: United States
facility: South Texas Institute of Cancer
state: Texas
city: Corpus Christi
country: United States
facility: Cancer Specialists of South Texas, P.A.
state: Texas
city: Dallas
country: United States
facility: Center for Oncology Research
state: Texas
city: Dallas
country: United States
facility: Texas Oncology, P.A.
state: Texas
city: Dallas
country: United States
facility: Texas Oncology - Baylor Charles A. Sammons Cancer Center
state: Texas
city: Dallas
country: United States
facility: University of Texas Southwestern Medical Center Simmons Cancer Center
state: Texas
city: Denton
country: United States
facility: Texas Oncology, P.A.
state: Texas
city: El Paso
country: United States
facility: El Paso Cancer Treatment Center - West
state: Texas
city: El Paso
country: United States
facility: Center for Integrative Cancer Medicine, PA
state: Texas
city: Fort Worth
country: United States
facility: Texas Oncology
state: Texas
city: Garland
country: United States
facility: Texas Oncology, P.A.
state: Texas
city: Houston
country: United States
facility: Texas Oncology - Memorial City
state: Texas
city: Houston
country: United States
facility: The Methodist Hospital Breast Center
state: Texas
city: Houston
country: United States
facility: Medicus Alliance Clinical Research Org., Inc.
state: Texas
city: Houston
country: United States
facility: Jabboury Foundation for Cancer Research, Inc.
state: Texas
city: Paris
country: United States
facility: Texas Oncology, P.A.
state: Texas
city: San Antonio
country: United States
facility: Cancer Care Centers of South Texas
state: Texas
city: San Antonio
country: United States
facility: South Texas Oncology & Hematology
state: Texas
city: Sugar Land
country: United States
facility: Texas Oncology P.A.
state: Texas
city: Tyler
country: United States
facility: East Texas Medical Center Cancer Institute
state: Texas
city: Tyler
country: United States
facility: Texas Oncology
state: Texas
city: Waco
country: United States
facility: Texas Oncology Cancer Care and Research Center
state: Texas
city: Ogden
country: United States
facility: North Utah Associates
state: Utah
city: Salt Lake City
country: United States
facility: Utah Cancer Specialists
state: Utah
city: Bennington
country: United States
facility: Southwestern Vermont Regional Cancer Center
state: Vermont
city: Rutland
country: United States
facility: Rutland Regional Medical Center
state: Vermont
city: Fairfax
country: United States
facility: Inova Schar Cancer Institute
state: Virginia
city: Fairfax
country: United States
facility: Virginia Cancer Specialists, PC
state: Virginia
city: Norfolk
country: United States
facility: Virginia Oncology Associates
state: Virginia
city: Kirkland
country: United States
facility: Cascade Cancer Center
state: Washington
city: Spokane
country: United States
facility: Cancer Care Northwest-North
state: Washington
city: Tacoma
country: United States
facility: Northwest Medical Specialties PLLC
state: Washington
city: Wenatchee
country: United States
facility: Wenatchee Valley Medical Center
state: Washington
city: Morgantown
country: United States
facility: West Virginia University Mary Babb Randolph Cancer Center
state: West Virginia
city: Wheeling
country: United States
facility: Wheeling Hospital
state: West Virginia
city: Green Bay
country: United States
facility: Aurora BayCare Medical Center
state: Wisconsin
city: Racine
country: United States
facility: Wheaton Franciscan Cancer Care-All Saints
state: Wisconsin
city: Sydney
country: Australia
facility: Sydney West Cancer Trials Centre
state: New South Wales
city: South Brisbane
country: Australia
facility: Iron Cancer Care South Brisbane
state: Queensland
city: Adelaide
country: Australia
facility: The Queen Elizabeth Hospital
state: South Australia
city: Kurralta Park
country: Australia
facility: Ashford Cancer Centre Research
state: South Australia
city: North Adelaide
country: Australia
facility: North Adelaide Oncology Calvary Hospital North Adelaide
state: South Australia
city: Melbourne
country: Australia
facility: Royal Melbourne Hospital
state: Victoria
city: Melbourne
country: Australia
facility: The Western Hospital
state: Victoria
city: Nedlands
country: Australia
facility: Hollywood Private Hospital
state: Western Australia
city: Nassau
country: Bahamas
facility: Affinity Research Limited
city: Aalst
country: Belgium
facility: OLVZ Medische Oncologie
city: Brugge
country: Belgium
facility: Az. St. Jan
city: Bruxelles
country: Belgium
facility: Cliniques Universitaires de Bruxelles
city: Hasselt
country: Belgium
facility: VZW Jesseziekenhuis - Campus Virga Jesse
city: Ieper
country: Belgium
facility: Jan Yperman Ziekenhuis
city: Kortrijk
country: Belgium
facility: AZ Groeninge ampus Maria's Voorzienigheid (MV) Oncologisch Centrum
city: Liege
country: Belgium
facility: Centre Hospitalier Regional de La Citadelle
city: Liège
country: Belgium
facility: CHU de Liège - Domaine Universitaire du Sart Tilman
city: Mons
country: Belgium
facility: C.H.U. Ambroise Paré
city: Oostende
country: Belgium
facility: AZ Damiaan - Site Sint-Jozef
city: Ronse
country: Belgium
facility: AZ Zusters van Barmhartigheid
city: Sint Niklaas
country: Belgium
facility: AZ Nikolaas
city: Turnhout
country: Belgium
facility: Sint-Elisabethziekenhuis
city: Porto Alegre
country: Brazil
facility: Hospital Sao Lucas da Pontificia Universidade Catolica do Rio Grande do Sul
state: RS
city: Plovdiv
country: Bulgaria
facility: District Dispensary for Oncology Diseases Internal Unit- Plovdiv EOOD, Ist
city: Plovdiv
country: Bulgaria
facility: District Dispensary for Oncology Diseases Internal Unit- Plovdiv EOOD, Second
city: Sofia
country: Bulgaria
facility: District Dispensary for Oncology Diseases Internal Unit- Sofia EOOD
city: Sofia
country: Bulgaria
facility: Specialised Hospital of Active Treatment in Oncology
city: Varna
country: Bulgaria
facility: Interdistrict Dispensary for Oncology Diseases
city: Edmonton
country: Canada
facility: Cross Cancer Institute
state: Alberta
city: Lethbridge
country: Canada
facility: Jack Ady Cancer Centre
state: Alberta
city: Vancouver
country: Canada
facility: BC Cancer Agency
state: British Columbia
city: Winnipeg
country: Canada
facility: CancerCare Manitoba
state: Manitoba
city: London
country: Canada
facility: London Regional Cancer Program
state: Ontario
city: Newmarket
country: Canada
facility: Stronach Regional Cancer Centre at Southlake
state: Ontario
city: Oshawa
country: Canada
facility: R.S. McLaughlin Durham Regional Cancer Centre
state: Ontario
city: Toronto
country: Canada
facility: University Health Network, Princess Margaret Hospital
state: Ontario
city: Weston
country: Canada
facility: Humber River Regional Hospital - Church Street Site
state: Ontario
city: Montreal
country: Canada
facility: Hopital Maisonneuve Rosemont
state: Quebec
city: Montreal
country: Canada
facility: C.H.U.M. - Hopital Notre-Dame, Departement d'Oncologie
state: Quebec
city: Montreal
country: Canada
facility: Hopital du Sacre-Coeur de Montreal
state: Quebec
city: Quebec
country: Canada
facility: Centre Hospitalier Affilie Universitaire de Quebec Hopital du St-Sacrement
city: Quebec
country: Canada
facility: CSSS Alphonse-Desjardins
city: Hangzhou
country: China
facility: Zhejiang Cancer Hospital
state: Zhejiang
city: Beijing
country: China
facility: Cancer Hospital, Chinese Academy of Medical Sciences
city: Beijing
country: China
facility: Peking Union Medical College Hospital of Chinese Academy of Medical Sciences
city: Beijing
country: China
facility: The Hospital Affiliated Academy Military Medical Science, Chinese People's
city: Beijing
country: China
facility: Chinese People's Liberation Army General Hospital
city: Guangzhou
country: China
facility: Sun Yat-Sen University Cancer Center
city: Guangzhou
country: China
facility: Southern Medical University Nanfang Hospital
city: Shanghai
country: China
facility: Fudan University Shanghai Cancer Center
city: Tianjin
country: China
facility: Tianjin Cancer Hospital
city: Monteria
country: Colombia
facility: Oncomedica S.A. IMAT
state: Cordoba
city: Pereira
country: Colombia
facility: Oncologos del Occidente
state: Risaralda
city: Bogota
country: Colombia
facility: Administradora Country S.A-Clinica del Country
city: Osijek
country: Croatia
facility: University Hospital Centre Osijek, Department of Radiotherapy and Oncology
city: Varazdin
country: Croatia
facility: General Hospital Varazdin
city: Zagreb
country: Croatia
facility: Klinicki bolnicki centar "Sestre Milosrdnice"
city: Zagreb
country: Croatia
facility: University Hospital Center Zagreb
city: Brno
country: Czechia
facility: Fakultni nemocnice Brno
city: Brno
country: Czechia
facility: Masarykuv Onkologicky ustav
city: Jihlava
country: Czechia
facility: Nemocnice Jihlava
city: Nova Ves pod Plesi
country: Czechia
facility: Institut Onkologie a Reahabilitace na Plesi
city: Pardubice
country: Czechia
facility: Multiscan s. r. o.
city: Praha
country: Czechia
facility: Fakultni Nemocnice v Motole
city: Aalborg
country: Denmark
facility: Aalborg Sygehus
city: Aarhus C
country: Denmark
facility: Aarhus University Hospital
city: Copenhagen
country: Denmark
facility: Rigshospitalet
city: Esbjerg
country: Denmark
facility: Sydvestjysk Sygehus
city: Herlev
country: Denmark
facility: Herlev Hospital
city: Hillerod
country: Denmark
facility: Hillerod Hospital
city: Naestved
country: Denmark
facility: Næstved Sygehus
city: Odense C
country: Denmark
facility: Odense Universitetshospital
city: Roskilde
country: Denmark
facility: Roskilde University Hospital
city: Sonderborg
country: Denmark
facility: Sygehus Sonderjylland
city: Vejle
country: Denmark
facility: Vejle Sygehus
city: Viborg
country: Denmark
facility: Regionshospital Viborg
city: Saint Herblain
country: France
facility: Centre Rene Gauducheau
state: Cedex
city: Bordeaux, Cedex
country: France
facility: C.H.U. De Bordeaux Saint Andre
city: Caen
country: France
facility: Centre François Baclesse
city: Clermont-Ferrand
country: France
facility: Centre Hospitalier de Montluçon
city: Dijon
country: France
facility: Centre Georges Francois Leclerc
city: Grenoble
country: France
facility: Oncologie department, Hopital albert Michalon
city: Le Chesnay
country: France
facility: Hopital de Versailles
city: Lille
country: France
facility: Centre Oscar Lambret
city: Paris Cedex 10
country: France
facility: Hopital Saint Louis
city: Paris cedex 13
country: France
facility: Hopital La Pitie-Salpetriere
city: Paris
country: France
facility: Institut Curie, Département d'Oncologie Médicale
city: Perigueux
country: France
facility: Service d'Oncologie et de Radiotherapie, Polyclinique Francheville, 38
city: Rouen, Cedex 1
country: France
facility: Centre Henri Becquerel
city: Saint Priest en Jarez
country: France
facility: Institute de Cancerologie de la Loire
city: Saint-Nazaire
country: France
facility: Pole Hospitalier Mutualiste
city: Strasbourg
country: France
facility: Clinique Sainte Anne Centre de Radiothérapie
city: Strasbourg
country: France
facility: CHU Strasbourg
city: Tours
country: France
facility: CHU Bretonneau Centre Henry Kaplan
city: Villejuif
country: France
facility: Institut Gustave Roussy
city: Villejuif
country: France
facility: CHU Paul Brousse
city: Aachen
country: Germany
facility: Marienhospital
city: Augsburg
country: Germany
facility: Onkologische Praxis
city: Bamberg
country: Germany
facility: Sozialstiftung Bamberg Klinik fuer Haematologie und Internistische Onkologie
city: Berlin
country: Germany
facility: Onkologische Schwerpunktpraxis
city: Berlin
country: Germany
facility: Praxisklinik Krebsheilkunde fuer Frauen
city: Berlin
country: Germany
facility: Onkologische Schwerpunktpraxis
city: Berlin
country: Germany
facility: Frauenarzt-Zentrum-Zehlendorf
city: Duesseldorf
country: Germany
facility: Universitaetsklinikum Duesseldorf, Frauenklinik
city: Duesseldorf
country: Germany
facility: Luisenkrankenhaus
city: Düsseldorf
country: Germany
facility: Universitaetsklinikum Duesseldorf
city: Erfurt
country: Germany
facility: Facharzt fuer Frauenheilkunde und Geburtshilfe
city: Frankfurt am Main
country: Germany
facility: Onkologische Gemeinschaftspraxis Frankfurt
city: Frankfurt am Main
country: Germany
facility: Frauenklinik der J.W. Goethe-Universitaet
city: Frankfurt am Main
country: Germany
facility: Staedtische Kliniken Frankfurt am Main-Hoechst Frauenklinik
city: Freiburg
country: Germany
facility: Praxis für interdisziplinaere Onkologie & Haematologie GbR
city: Georgsmarienhuette
country: Germany
facility: Klinikum St. Georg/Franziskus, Abteilung fuer Senologie
city: Hameln
country: Germany
facility: Kreiskrankenhaus Hameln, Onkologische Ambulanz
city: Hannover
country: Germany
facility: Facharzt fuer Frauenheilkunde
city: Heidelberg
country: Germany
facility: Onkologische Schwerpunktpraxis
city: Heidelberg
country: Germany
facility: Nationales Centrum fuer Tumorerkrankungen
city: Kempten
country: Germany
facility: Klinikum Kempten - Oberallgaeu
city: Kiel
country: Germany
facility: MTV Abts & Partner Kiel
city: Luebeck
country: Germany
facility: Universitaetsfrauenklinikum Schleswig-Holstein
city: Magdeburg
country: Germany
facility: Universitaetsklinikum Magdeburg A.oe.R.
city: Mainz
country: Germany
facility: Klinikum der Johannes-Gutenberg-Universitaet
city: Muenchen
country: Germany
facility: Fachpraxis fuer Innere Medizin
city: Muenchen
country: Germany
facility: Klinik und Poliklinik fuer
city: Muenchen
country: Germany
facility: Praxis Gynaekologie Arabella Muenchen
city: Offenbach
country: Germany
facility: Klinik fuer Gynaekologie und Geburtshilfe
city: Oldenburg
country: Germany
facility: Pius-Hospital Oldenburg
city: Oldenburg
country: Germany
facility: Klinikum Oldenburg GmbH
city: Recklinghausen
country: Germany
facility: Oncologianova GmbH
city: Tuebingen
country: Germany
facility: Universitaetsfrauenklinik Tuebingen
city: Vechta
country: Germany
facility: St. Marienhospital Vechta
city: Westerstede
country: Germany
facility: Gemeinschaftspraxis fuer Haematologie und Onkologie
city: Wiesbaden
country: Germany
facility: Klinik für Gynaekologie und gyn. Onkologie
city: Witten
country: Germany
facility: Marienhospital Witten
city: Heraklion
country: Greece
facility: University Hospital of Heraklion
state: Creete
city: Chania
country: Greece
facility: General Hospital of Chania Ag. Georgios
state: Crete
city: Alexandroúpoli
country: Greece
facility: University General Hospital of Alexandroupoli, Department of Medical Oncology
city: Athens
country: Greece
facility: Hippokratio General Hospital of Athens
city: Athens
country: Greece
facility: Hippokration Hospital Athens
city: Larissa
country: Greece
facility: University General Hospital of Larissa
city: Rio Patras
country: Greece
facility: University Hospital of Patras
city: Thessaloniki
country: Greece
facility: Euromedica General Clinic
city: Hong Kong
country: Hong Kong
facility: UNIMED Medical Institute, Comprehensive Centre for Breast Diseases
state: Wanchai
city: Hong Kong
country: Hong Kong
facility: Department of Clinical Oncology, Tuen Mun Hospital
city: Hong Kong
country: Hong Kong
facility: Queen Mary Hospital, Department of Clinical Oncology, Professorial Block
city: Hong Kong
country: Hong Kong
facility: Queen Mary Hospital, Department of Medicine, Blk K
city: Hong Kong
country: Hong Kong
facility: Queen Mary Hospital, Department of Medicine
city: Budapest
country: Hungary
facility: Semmelweis Egyetem Radiologiai és Onkoterapias Klinika
city: Budapest
country: Hungary
facility: Fovarosi Onkormanyzat Szent Imre Korhaz
city: Budapest
country: Hungary
facility: Orszagos Onkologiai Intezet "B" Belgyogyaszati osztaly
city: Gyula
country: Hungary
facility: Bekes M. Kepviselotest. Pandy Kalman Korhaz, Megyei Onkol. Kp., Klin. Onkol. es Sugartherapias Oszt.
city: Kaposvar
country: Hungary
facility: Kaposi Mor Oktato Korhaz, Onkologiai Centrum
city: Kecskemet
country: Hungary
facility: Bacs-Kiskun Megyei Korhaz Onkoradiologiai Kozpont
city: Miskolc
country: Hungary
facility: Borsod-Abauj-Zemplen M. Korhaz es Egyetemi Okt. K., Klin. Onk., Sugarterapias es Kozp. Szuro Centrum
city: Nyiregyhaza
country: Hungary
facility: Josa Andras Oktatokorhaz Egeszsegugyi Szolgaltato Nonprofit Kft. / Onkoradiologiai Osztaly
city: Veszprem
country: Hungary
facility: Veszprem Megyei Csolnoky Ferenc Korhaz Nonprofit Zrt.
city: Beer Sheva
country: Israel
facility: Soroka University MC, Department of Oncology
city: Haifa
country: Israel
facility: Rambam Health care campus, Oncology institute
city: Rehovot
country: Israel
facility: Kaplan Medical Center, Department of Oncology
city: Tel Hashomer
country: Israel
facility: Sheba Medical Center, Oncology Institute Tel Hashomer
city: Avellino
country: Italy
facility: Azienda Ospedaliera San Giuseppe Moscati
city: Brindisi
country: Italy
facility: Presidio Ospedaliero di Summa - Antonio Perrino
city: Catania
country: Italy
facility: Azienda Ospedaliera Universitaria "Policlinico Vittorio Emanuele"
city: Catanzaro
country: Italy
facility: Fondazione per la Ricerca e la Cura dei Tumori Tommaso Campanella
city: Monza
country: Italy
facility: Azienda Ospedaliera San Gerardo
city: Napoli
country: Italy
facility: Fondazione Giovanni Pascale
city: Napoli
country: Italy
facility: Unita' Operativa Complessa Oncologia Medica, A.O.R.N. "Cardarelli"
city: Orbassano (TO)
country: Italy
facility: Azienda Ospedaliera San Luigi Gonzaga
city: Padova
country: Italy
facility: IRCCS Istituto Oncologico Veneto di Padova
city: Pisa
country: Italy
facility: Azienda Ospedaliero-Universitaria Pisana
city: Reggio Calabria
country: Italy
facility: Azienda Ospedaliera Bianchi Melacrino Morelli
city: Roma
country: Italy
facility: Universita Campus Bio-Medico
city: Roma
country: Italy
facility: Oncologia Medica A, Istituti Fisioterapici Ospitalieri
city: Roma
country: Italy
facility: Ospedale San Pietro Fatebenefratelli
city: Sora (FR)
country: Italy
facility: Ospedale SS Trinita
city: Terni
country: Italy
facility: Azienda Ospedaliera S. Maria
city: Treviglio, BG
country: Italy
facility: Ospedale Treviglio e Caravaggio, UO Oncologia Medica
city: Viagrande (CT)
country: Italy
facility: Istituto Oncologico del Mediterraneo
city: Viterbo
country: Italy
facility: Ospedale Belcolle Viterbo
city: Aichi
country: Japan
facility: Aichi Cancer Center
city: Chiba
country: Japan
facility: Chiba Cancer Center
city: Chiba
country: Japan
facility: National Cancer Center Hospital East
city: Ehime
country: Japan
facility: National Hospital Organization Shikoku Cancer Center
city: Fukuoka
country: Japan
facility: National Hospital Organization Kyushu Cancer Center
city: Fukuoka
country: Japan
facility: Kurume Daiichi Social Insurance Hospital
city: Hiroshima
country: Japan
facility: Hiroshima City Hospital
city: Hokkaido
country: Japan
facility: National Hospital Organization Hokkaido Cancer Center
city: Hyogo
country: Japan
facility: Hyogo Cancer Center
city: Kagoshima
country: Japan
facility: Hakuaikai Medical Corporation Sagara Hospital
city: Kanagawa
country: Japan
facility: Kanagawa Cancer Center
city: Kanagawa
country: Japan
facility: Tokai University Hospital
city: Kumamoto
country: Japan
facility: Kumamoto Municipal Hospital
city: Kyoto
country: Japan
facility: Kyoto University Hospital
city: Niigata
country: Japan
facility: Niigata Cancer Center Hospital 2-15-3
city: Osaka
country: Japan
facility: Osaka Medical Center for Cancer and Cardiovascular Diseases
city: Osaka
country: Japan
facility: National Hospital Organization Osaka National Hospital
city: Osaka
country: Japan
facility: Osaka University Hospital
city: Saitama
country: Japan
facility: Saitama Cancer Center
city: Shizuoka
country: Japan
facility: Shizuoka Cancer Center
city: Tochigi
country: Japan
facility: Jichi Medical University Hospital
city: Tokyo
country: Japan
facility: Tokyo Metropolitan Cancer and Infectious disease Center Komagome Hp
city: Tokyo
country: Japan
facility: The Cancer Institute Hospital of Japanese Foundation for Cancer Research
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
state: Korea
city: Gyeonggi-do
country: Korea, Republic of
facility: National Cancer Center, Center for Breast Cancer
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital, Department of Internal Medicine
city: Seoul
country: Korea, Republic of
facility: Korea University Anam Hospital, Department of Oncology/Hematology
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center
city: Kaunas
country: Lithuania
facility: The Hospital of Lithuanian University of Health Sciences Kauno klinikos Oncology and Haematology Clinic
city: Vilnius
country: Lithuania
facility: Oncology Institute of Vilnius University
city: Kuala Lumpur
country: Malaysia
facility: University Malaya Medical Centre
city: Floriana
country: Malta
facility: Sir Paul Boffa Hospital
city: Guadalajara
country: Mexico
facility: Nucleo de Especialidades Oncológicas
state: Jalisco
city: Amstelveen
country: Netherlands
facility: Ziekenhuis Amstelland
city: Apeldoorn
country: Netherlands
facility: Gelre ZH
city: Breda
country: Netherlands
facility: Amphia Ziekenhuis - Interne Geneeskunde
city: Den Haag
country: Netherlands
facility: Haga Ziekenhuis
city: Eindhoven
country: Netherlands
facility: Maxima Medisch Centrum
city: Schiedam
country: Netherlands
facility: Vlietland Ziekenhuis
city: Sittard-Geleen
country: Netherlands
facility: Orbis Medisch Centrum
city: Auckland
country: New Zealand
facility: Auckland Hospital
city: Skopje
country: North Macedonia
facility: University Clinic for Radiotherapy and Oncology
city: Surco
country: Peru
facility: Clínica Vista Alegre / Unidad de Investigacion
state: Lima
city: Bialystok
country: Poland
facility: Bialostockie Centrum Onkologii im. M. Sklodowskiej- Curie w Bialymstoku
city: Bydgoszcz
country: Poland
facility: Centrum Onkologii im. prof. Franciszka Łukaszczyka
city: Bydgoszcz
country: Poland
facility: Centrum Medyczne Ostrobramska Niepubliczny Zaklad Opieki Zdrowotnej "Magodent"
city: Gdansk
country: Poland
facility: Uniwersyteckie Centrum Kliniczne w Gdansku
city: Gdynia
country: Poland
facility: Szpital Morski im. PCK Gdynskie Centrum Onkologii Oddzial Chemioterapii
city: Jelenia Gora
country: Poland
facility: Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Wojewodzki Oddzial
city: Krakow
country: Poland
facility: Samodzielny Publiczny Zaklad Opieki Zdrowotnej Szpital Uniwersytecki w
city: Olsztyn
country: Poland
facility: Zaklad Opieki Zdrowotnej MSWiA z Warminsko - Mazurskim Centrum Onkologii w
city: Olsztyn
country: Poland
facility: Olsztynski Osrodek Onkologiczny Kopernik Sp. z o.o.
city: Tarnow
country: Poland
facility: Szpital Wojewodzki im. Sw. Lukasza Samodzielny Publiczny Zaklad Opieki
city: Warszawa
country: Poland
facility: Centrum Medyczne Ostrobramska Niepubliczny Zaklad Opieki Zdrowotnej "Magodent"
city: Cluj-Napoca
country: Romania
facility: Institutul Oncologic "Prof. Dr. Ion Chiricuta"
state: Cluj
city: Craiova
country: Romania
facility: SC Oncolab S.R.L.
state: Dolj
city: Bucuresti
country: Romania
facility: Spitalul Universitar de Urgenta Bucuresti
city: Belgrade
country: Serbia
facility: Institute of Oncology and Radiology of Serbia
city: Nis
country: Serbia
facility: Clinical centre Nis
city: Singapore
country: Singapore
facility: National Cancer Centre Singapore
city: Bratislava
country: Slovakia
facility: Interna onkologicka klinika
city: Kosice
country: Slovakia
facility: Oddelenie radioterapie a onkologie
city: Poprad
country: Slovakia
facility: Poliklinika ADUS
city: Elche
country: Spain
facility: Hospital General Universitario de Elche
state: Alicante
city: Torrevieja
country: Spain
facility: Hospital de Torrevieja
state: Alicante
city: Badalona
country: Spain
facility: Hospital Universitari Germans Trias i Pujol
state: Barcelona
city: Hospitalet de Llobregat
country: Spain
facility: ICO de Barcelona - Hospital Duran i Reynals, Hospitalet de Llobregat Consorci Sanitari de Terrassa
state: Barcelona
city: Terrassa
country: Spain
facility: Hospital Mutua de Terrassa
state: Barcelona
city: Terrassa
country: Spain
facility: Consorci Sanitari de Terrassa
state: Barcelona
city: Barbastro
country: Spain
facility: Hospital de Barbastro
state: Huesca
city: Palma de Mallorca
country: Spain
facility: Hospital Universitari Son Espases
state: Islas Baleares
city: Alcorcon
country: Spain
facility: Hospital Universitario Fundacion de Alcorcon
state: Madrid
city: Majadahonda
country: Spain
facility: Hospital Puerta de Hierro-Majadahonda
state: Madrid
city: La Laguna
country: Spain
facility: Hospital Universitario de Canarias
state: Santa Cruz De Tenerife
city: Bilbao
country: Spain
facility: Hospital De Basurto
state: Vizcaya
city: A Coruna
country: Spain
facility: Centro Oncologico de Galicia
city: Barcelona
country: Spain
facility: Hospital Universitario Vall D´Hebron
city: Barcelona
country: Spain
facility: Hospital Clinic i Provincial de Barcelona
city: Caceres
country: Spain
facility: Hospital San Pedro de Alcantara
city: Cadiz
country: Spain
facility: Hospital Universitario Puerta del Mar
city: Castellon
country: Spain
facility: Consorcio Hospitalario Provincial de Castellon
city: Cordoba
country: Spain
facility: Hospital Universitario Reina Sofia
city: Girona
country: Spain
facility: ICO de Girona - Hospital Universitario de Girona Dr. Josep Trueta
city: Guadalajara
country: Spain
facility: Hospital Universitario de Guadalajara
city: Jaen
country: Spain
facility: Complejo Hospitalario de Jaen
city: Las Palmas de Gran Canaria
country: Spain
facility: Hospital Universitario Insular de Gran Canaria
city: Lleida
country: Spain
facility: Hospital Universitari Arnau de Vilanova de Lleida
city: Madrid
country: Spain
facility: Hospital General Universitario Gregorio Marañon
city: Madrid
country: Spain
facility: Hospital Universitario Ramon y Cajal
city: Madrid
country: Spain
facility: Hospital Clinico San Carlos
city: Madrid
country: Spain
facility: Hospital Madrid Norte Sanchinarro. Centro Integral Oncologico Clara Campal
city: Malaga
country: Spain
facility: Hospital Clinico Universitario Virgen de La Victoria
city: Santa Cruz de Tenerife
country: Spain
facility: Hospital Universitario Nuestra Señora de Candelaria
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen del Rocio
city: Toledo
country: Spain
facility: Hospital Virgen de la Salud
city: Valencia
country: Spain
facility: Fundacion Instituto Valenciano de Oncologia
city: Valencia
country: Spain
facility: Hospital Clinico Universitario de Valencia
city: Zamora
country: Spain
facility: Hospital Provincial de Zamora
city: Zaragoza
country: Spain
facility: Hospital Universitario Miguel Servet
city: Lund
country: Sweden
facility: Onkologiska Kliniken
city: Lund
country: Sweden
facility: Skanes Onkologiska Kliniken
city: Aarau
country: Switzerland
facility: Hirslanden Medical Center Tumor Center
city: Baden
country: Switzerland
facility: Kantonsspital Baden
city: Olten
country: Switzerland
facility: Kantonsspital Olten-Medizinische Onkologie
city: Thun
country: Switzerland
facility: Spital STS AG
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Medical University Chung-Ho memorial Hospital
city: Kwei-Shan, Taoyuan
country: Taiwan
facility: Chang Gung Medical Foundation, Linkou Branch
city: Taipei TOC
country: Taiwan
facility: National Taiwan University Hospital
city: Besevler/Ankara
country: Turkey
facility: Gazi Universitesi Tip Fakultesi
city: Bornova/Izmir
country: Turkey
facility: Ege Universitesi Tip Fakultesi
city: Capa/Istanbul
country: Turkey
facility: Istanbul Universitesi Istanbul Tip Fakultesi
city: Cerrahpasa/Istanbul
country: Turkey
facility: Istanbul Universitesi Cerrahpasa Tip Fakultesi, Ic Hastaliklari Anabilim Dali
city: Demetevler/Ankara
country: Turkey
facility: Dr. Abdurrahman Yurtaslan Onkoloji Egitim ve Arastirma Hastanesi
city: Gorukle/Bursa
country: Turkey
facility: Uludag Universitesi Tip Fakultesi
city: Inciralti/Izmir
country: Turkey
facility: Dokuz Eylul Universitesi Tip Fakultesi
city: Istanbul
country: Turkey
facility: Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi
city: Sehitkamil/Gaziantep
country: Turkey
facility: Gaziantep Universitesi
city: Sihhiye/Ankara
country: Turkey
facility: Hacettepe Universitesi Tip Fakultesi
city: Rhyl
country: United Kingdom
facility: Betsi Cadwaladr University Health Board
state: Denbighshire
city: Burton-on-Trent
country: United Kingdom
facility: Queens Hospital
state: Staffs
city: Leeds
country: United Kingdom
facility: St James's University Hospital
city: Leicester
country: United Kingdom
facility: University Hospitals of Leicester
city: London
country: United Kingdom
facility: St. Bartholomew's Hospital
city: London
country: United Kingdom
facility: Guy's Hospital
city: London
country: United Kingdom
facility: Charing Cross Hospital, Department Of Medical Oncology
city: Manchester
country: United Kingdom
facility: Christie Hospital
city: Norwich
country: United Kingdom
facility: Norfolk & Norwich University Hospitals
city: Nottingham
country: United Kingdom
facility: Nottingham City Hospital
city: Sheffield
country: United Kingdom
facility: Weston Park Hospital
city: Swansea
country: United Kingdom
facility: Singleton Hospital
city: Westcliff-on-Sea
country: United Kingdom
facility: Southend University Hospital
Study officials:
affiliation: Puma Biotechnology, Inc.
name: Senior Vice President Clinical Science and Pharmacology
role: STUDY_DIRECTOR
References:
citation: Iwata H, Masuda N, Kim SB, Inoue K, Rai Y, Fujita T, Chiu J, Ohtani S, Takahashi M, Miyaki T, Lu YS, Xu B, Yap YS, Bustam A, Yao B, Zhang B, Bryce R, Chan A. Neratinib after trastuzumab-based adjuvant therapy in patients from Asia with early stage HER2-positive breast cancer. Future Oncol. 2019 Jul;15(21):2489-2501. doi: 10.2217/fon-2019-0143. Epub 2019 May 29.
citation: Chia SKL, Martin M, Holmes FA, Ejlertsen B, Delaloge S, Moy B, Iwata H, von Minckwitz G, Mansi J, Barrios CH, Gnant M, Tomasevic Z, Denduluri N, Separovic R, Kim SB, Jakobsen EH, Harvey V, Robert N, Smith J 2nd, Harker G, Zhang B, Eli LD, Ye Y, Lalani AS, Buyse M, Chan A. PIK3CA alterations and benefit with neratinib: analysis from the randomized, double-blind, placebo-controlled, phase III ExteNET trial. Breast Cancer Res. 2019 Mar 11;21(1):39. doi: 10.1186/s13058-019-1115-2.
citation: Mortimer J, Di Palma J, Schmid K, Ye Y, Jahanzeb M. Patterns of occurrence and implications of neratinib-associated diarrhea in patients with HER2-positive breast cancer: analyses from the randomized phase III ExteNET trial. Breast Cancer Res. 2019 Feb 27;21(1):32. doi: 10.1186/s13058-019-1112-5.
citation: Delaloge S, Cella D, Ye Y, Buyse M, Chan A, Barrios CH, Holmes FA, Mansi J, Iwata H, Ejlertsen B, Moy B, Chia SKL, Gnant M, Smichkoska S, Ciceniene A, Martinez N, Filipovic S, Ben-Baruch NE, Joy AA, Langkjer ST, Senecal F, de Boer RH, Moran S, Yao B, Bryce R, Auerbach A, Fallowfield L, Martin M. Effects of neratinib on health-related quality of life in women with HER2-positive early-stage breast cancer: longitudinal analyses from the randomized phase III ExteNET trial. Ann Oncol. 2019 Apr 1;30(4):567-574. doi: 10.1093/annonc/mdz016.
citation: Martin M, Holmes FA, Ejlertsen B, Delaloge S, Moy B, Iwata H, von Minckwitz G, Chia SKL, Mansi J, Barrios CH, Gnant M, Tomasevic Z, Denduluri N, Separovic R, Gokmen E, Bashford A, Ruiz Borrego M, Kim SB, Jakobsen EH, Ciceniene A, Inoue K, Overkamp F, Heijns JB, Armstrong AC, Link JS, Joy AA, Bryce R, Wong A, Moran S, Yao B, Xu F, Auerbach A, Buyse M, Chan A; ExteNET Study Group. Neratinib after trastuzumab-based adjuvant therapy in HER2-positive breast cancer (ExteNET): 5-year analysis of a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Oncol. 2017 Dec;18(12):1688-1700. doi: 10.1016/S1470-2045(17)30717-9. Epub 2017 Nov 13.
citation: Chan A, Delaloge S, Holmes FA, Moy B, Iwata H, Harvey VJ, Robert NJ, Silovski T, Gokmen E, von Minckwitz G, Ejlertsen B, Chia SKL, Mansi J, Barrios CH, Gnant M, Buyse M, Gore I, Smith J 2nd, Harker G, Masuda N, Petrakova K, Zotano AG, Iannotti N, Rodriguez G, Tassone P, Wong A, Bryce R, Ye Y, Yao B, Martin M; ExteNET Study Group. Neratinib after trastuzumab-based adjuvant therapy in patients with HER2-positive breast cancer (ExteNET): a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial. Lancet Oncol. 2016 Mar;17(3):367-377. doi: 10.1016/S1470-2045(15)00551-3. Epub 2016 Feb 10.