Clinical trial NCT05346211: The Effect of Curcumin Supplementation on Recovery From Exercise-induced Muscle Damage
Official title: The Effect of Curcumin Supplementation on Recovery From Exercise-induced Muscle Damage
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Exercise Induced Muscle Damage
Lead sponsor: St Mary's University College
Sponsor class: OTHER
First posted: 2022-04-26
Enrollment: 36
Sex: ALL
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: Recent evidence suggests that curcumin supplementation may reduce muscle inflammation, oxidative markers, and muscle damage. The most favourable dosage to elicit these ergogenic effects are yet to be established; both 750mg \& 1500mg has been shown to be effective. Curcumin supplementation has been ingested in numerous different ways however, no previous research to date has used curcumin in a hydrolysed (drinkable) format. The aim of this study is to investigate whether hydrolysed curcumin can reduce indices of muscle damage and improve recovery, whilst also examining a potential dose-response effect.


Eligibility criteria: Inclusion Criteria:

Inclusion criteria are as follows:

* between the age of 18-35
* non-smoker
* no previous history of cardiovascular, respiratory, or neurological problems
* not taking anticoagulant medication
* injury-free in the 3 months prior to scheduled participation in the study

Exclusion Criteria:

Exclusion criteria include:

* hypertension (\<140/80)
* any blood diseases or clotting issues,
* injury, or previous injury in \<3 months

Primary outcomes:
measure: Blood markers
timeFrame: Baseline
measure: Blood markers
timeFrame: immediately post muscle damage intervention
measure: Blood markers
timeFrame: 24 hours post
measure: Blood markers
timeFrame: 48 hours post
measure: Blood markers
timeFrame: 72 hours post
measure: Ford and Fort
timeFrame: Baseline
measure: Ford and Fort
timeFrame: Immediately post muscle damage intervention
measure: Ford and Fort
timeFrame: 24 hours post
measure: Ford and Fort
timeFrame: 48 hours post
measure: Ford and Fort
timeFrame: 72 hours post
measure: Soreness
timeFrame: Baseline
measure: Soreness
timeFrame: Immediately post muscle damage intervention
measure: Soreness
timeFrame: 24 hours post
measure: Soreness
timeFrame: 48 hours post
measure: Soreness
timeFrame: 72 hours post
measure: Soreness
timeFrame: Baseline
measure: Soreness
timeFrame: Immediately post muscle damage intervention
measure: Soreness
timeFrame: 24 hours post
measure: Soreness
timeFrame: 48 hours post
measure: Soreness
timeFrame: 72 hours post
measure: Soreness
timeFrame: Baseline
measure: Soreness
timeFrame: Immediately post muscle damage intervention
measure: Soreness
timeFrame: 24 hours post
measure: Soreness
timeFrame: 48 hours post
measure: Soreness
timeFrame: 72 hours post
measure: Muscle Structure
timeFrame: Baseline
measure: Muscle Structure
timeFrame: Immediately post muscle damage intervention
measure: Muscle Structure
timeFrame: 24 hours post
measure: Muscle Structure
timeFrame: 48 hours post
measure: Muscle Structure
timeFrame: 72 hours post
measure: Muscle Function
timeFrame: Baseline
measure: Muscle Function
timeFrame: Immediately post muscle damage intervention
measure: Muscle Function
timeFrame: 24 hours post
measure: Muscle Function
timeFrame: 48 hours post
measure: Muscle Function
timeFrame: 72 hours post
measure: Muscle Function
timeFrame: Baseline
measure: Muscle Function
timeFrame: Immediately post muscle damage intervention
measure: Muscle Function
timeFrame: 24 hours post
measure: Muscle Function
timeFrame: 48 hours post
measure: Muscle Function
timeFrame: 72 hours post
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Northumbria University
name: Luke Hughes, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: St. Mary's University, Twickenham
name: Jess Hill, PhD
role: PRINCIPAL_INVESTIGATOR
References: