Clinical trial NCT05585099: Effects of Lower Body Positive Pressure in People With Knee Osteoarthritis
Official title: Effects of Retro Walking Exercise Using Lower Body Positive Pressure on Knee Pain and Physical Function in People With Knee Osteoarthritis
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Knee Osteoarthritis
Lead sponsor: Qassim University
Sponsor class: OTHER
First posted: 2022-10-18
Enrollment: 26
Sex: ALL
Minimum age (years): 40
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The goal of this clinical trial is to compare effects of retro walking exercise versus forward walking using lower body positive pressure on knee pain, physical function, and quadriceps muscle strength in people with mild to moderate knee OA. The secondary aim is to compare effects of retro walking exercise versus forward walking using lower body positive pressure on mobility function, balance, and self-reported health outcomes in people with mild to moderate knee OA. The main questions it aims to answer are:

* Does retro walking exercise improve knee pain, physical function and Quadriceps muscle strength compared to forward walking exercise using lower body positive pressure in people with mild to moderate knee osteoarthritis?
* Does retro walking exercise improve Mobility function, balance, and self-reported health outcomes compared to forward walking exercise using lower body positive pressure in people with mild to moderate knee osteoarthritis?

Participants will walk (retro versus forward) on a lower body positive pressure treadmill.

If there is a comparison group: Researchers will compare \[retro walking compares to forward walking\] to see if \[improve in knee pain, physical function, and quadriceps muscles strength\]


Eligibility criteria: Inclusion Criteria:

* Mild to moderate knee osteoarthritis
* Edge bigger or equal 40 years
* Knee pain reported by participants in the past 30 days
* One or both knees osteoarthritis graded with Kellgren \& Lawrence grade 1 - 3

Exclusion Criteria:

* If they didn't meet the inclusion criteria
* History of hip, knee or ankle injury or surgery within the last year
* Kellgren \& Lawrence grade \> 3 of severe knee OA
* Diagnosed with rheumatoid arthritis
* History of knee injection with any medicine that reduce pain within the last year
* History of other medical condition that would disturb normal walking function
* Receive physical therapy in the last three months
* Pregnant
* Other conditions that are Contra indication to lower body positive pressure.

Primary outcomes:
measure: Numeric pain rating scale
timeFrame: Change from baseline pain at 6 weeks
measure: Knee injury and osteoarthritis outcome score (KOOS)
timeFrame: Change from baseline pain, symptoms, and level of disability at 6 weeks.
measure: Thigh muscle strength test
timeFrame: Change from baseline thigh muscle strength at 6 weeks.
Secondary outcomes:
measure: Five times sit to stand test
timeFrame: Change from baseline balance at 6 weeks.
measure: 3-M Backward Walk Test
timeFrame: Change from baseline backward walking at six weeks.
measure: Timed up and go test
timeFrame: Change from baseline Functional mobility at six weeks.
measure: 4 square step test
timeFrame: Change from baseline dynamic balance and coordination at six weeks
measure: Functional reach test
timeFrame: Change from baseline static balance at six weeks
measure: 10-Meter Walk Test
timeFrame: Change from baseline walking speed at six weeks
measure: 6 minute walk test
timeFrame: Change from baseline aerobic capacity and endurance at six week
measure: Medical Outcomes Study Short Form 12 (SF-12)
timeFrame: Change from baseline quality of life at six weeks
measure: Patient Health Questionnaire -9
timeFrame: Change from baseline depression at six week
measure: Rapid Assessment of Physical Activity
timeFrame: Change from baseline physical activity at six week
Other outcomes:
Locations:
city: Buraydah
country: Saudi Arabia
facility: Qassim university medical city
state: Almuledia
city: Buraidah
country: Saudi Arabia
facility: Medical City in Qassim University
Study officials:
References: