Clinical trial NCT05261061: Prognosis of Geriatric Patients 1 Year After Hospitalization for COVID-19
Official title: Prognosis of Geriatric Patients 1 Year After Hospitalization for COVID-19
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: COVID-19
Keywords: COVID-19
1-year prognosis
older patients
Lead sponsor: Assistance Publique - Hôpitaux de Paris
Sponsor class: OTHER
First posted: 2022-03-02
Enrollment: 1000
Sex: ALL
Minimum age (years): 75
Standard ages: OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All consecutive patients hospitalized in acute geriatric unit for medical reason (COVID or other)

Brief summary: Old patients hospitalized in Acute Geriatric Units are characterize by advanced age, frailty, high number of comorbidities, cognitive impairment and loss of functional autonomy. Although, intra-hospital mortality in geriatric population (out of COVID) is low (6%) the long-term prognosis is often worse (30 to 60% of loss of autonomy and 30% of one-year mortality among hospital survivors).

For geriatric patients with COVID19, intra-hospital mortality is higher than in younger Covid patients (1), but also higher than in geriatric patients outside the Covid context (30 vs 6% (2, 3)). Our hypothesis is that geriatric patients surviving hospitalization for COVID-19 have a worse vital and functional prognosis at 12 months than geriatric patients surviving hospitalization for another medical reason.

Detailed description: Old patients hospitalized in Acute Geriatric Units are characterize by advanced age (average 85 years), frailty, high number of comorbidities, cognitive impairment and loss of functional autonomy.These particular state leads to multiple decompensations and the reason for initial hospitalization is often only the "tip of the iceberg". Although, intra-hospital mortality in geriatric population (out of COVID) is low (6%) the long-term prognosis is often worse (30 to 60% of loss of autonomy and 30% of one-year mortality among hospital survivors).

For geriatric patients with COVID19, intra-hospital mortality is higher than in younger Covid patients (1), but also higher than in geriatric patients outside the Covid context (30 vs 6% (2, 3)). This excess mortality is all the more surprising as these patients seem to have fewer comorbidities than those usually hospitalized in acute geriatric units.

Our hypothesis is that geriatric patients surviving hospitalization for COVID-19 have a worse vital and functional prognosis at 12 months than geriatric patients surviving hospitalization for another medical reason.

Eligibility criteria: Inclusion Criteria:

* Age \>=75 years
* Hospitalized for medical reason in acute geriatric unit
* Alive at hospital discharge

Exclusion Criteria:

* Patients hospitalized for surgical reason
* Patients under legal protection
* Patient refusal

Primary outcomes:
measure: One-year mortality
timeFrame: 1 year
Secondary outcomes:
measure: Activity of daily living (ADL) at 1 year
timeFrame: 1 year
measure: SF-12 at one year
timeFrame: 1 year
measure: Clinical Frailty Scale (CFS) at one year
timeFrame: 1 year
measure: rehospitalization at one year
timeFrame: 1 year
Other outcomes:
Locations:
city: Paris
country: France
facility: Service de gériatrie, Hôpital Saint Antoine
Study officials:
affiliation: AP-HP- Sorbonne université
name: Hélène VALLET, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References: