Clinical trial NCT05918783: Padeliporfin VTP Using Robotic Assisted Bronchoscopy in Peripheral Lung Cancer
Official title: A Multicenter Open-label Phase 1/1b Study to Evaluate Safety, Feasibility and Early Treatment Effect of Padeliporfin VTP Using Robotic Assisted Bronchoscopy and Cone Beam CT Guidance in Patients With Peripheral Lung Cancer
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE1
Conditions: Peripheral Lung Tumor
Lead sponsor: Impact Biotech Ltd
Sponsor class: INDUSTRY
First posted: 2023-06-26
Enrollment: 36
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: SEQUENTIAL
Intervention model description: Part B recruitment will be opened upon completion of Part A light dose escalation.
Primary purpose: TREATMENT

Brief summary: Phase 1/1b, safety, feasibility, and light dose titration study followed by further study of therapeutic ablation effects.

Patients with high risk of peripheral primary lung cancer, stage 1A1/1A2, for whom surgical treatment is planned, will be recruited. Surgery will be performed at 5-21 days following the VTP procedure.

Study intervention: robotic assisted bronchoscopic Padeliporfin VTP lung ablation: vascular targeted photodynamic therapy using Padeliporfin photosensitizer.

Detailed description: A multicenter, open label, phase 1/1b, safety, feasibility, and light dose titration study followed by further study of therapeutic ablation effects.

Patients with high risk of peripheral primary lung cancer, stage 1A1/1A2, for whom surgical treatment is planned, will be recruited. Patients who are candidates for lung resection will be recruited as a diagnose and treat in the same anaesthesia, protocol; surgery will be performed at least 5 days and up to 21 days following the VTP procedure.

Study intervention will consist of robotic assisted bronchoscopic Padeliporfin VTP lung ablation: vascular targeted photodynamic therapy using Padeliporfin photosensitizer, an ablation mechanism with efficacy related to immune response post-ablation.

Eligibility criteria: Inclusion Criteria:

1. Age ≥18
2. Patients with primary lung lesions who are at high risk for primary lung cancer.

   2.1.Biopsy with intraoperative confirmation of malignancy using on-site cytology will be used as final inclusion prior to study treatment.
3. All patients will be approved by a multi-disciplinary team (thoracic surgery, interventional pulmonology, medical oncology and radiation oncology) as appropriate for bronchoscopic VTP prior to surgical resection.
4. Tumor size targeted for VTP treatment ≤ 2 cm (Part A) and \<3cm (Part B), based on CT scan, including solid or semi-solid tumors.
5. EBUS mediastinal staging performed intraoperative prior to VTP treatment with rapid on-site evaluation negative for nodal involvement of malignancy.
6. Tumor is ≥ 2cm from the central bronchial tree (distal 2 cm of the trachea, carina, and named major lobar bronchi up to their first bifurcation) (Timmerman, 2018).
7. Lung lesion is not contiguous with and ≥ 1 cm from the pleura/fissures.
8. Patient is eligible to undergo bronchoscopy under general anesthesia.
9. Tumor is accessible for Padeliporfin VTP treatment via robotic bronchoscopy
10. ECOG performance score 0-2
11. Estimated life expectancy of ≥3 months
12. Adequate organ system function
13. Negative serum pregnancy test

Exclusion Criteria:

1. Patient has a centrally located lung lesion, as defined by RTOG within 2 cm of the proximal bronchial tree, or within 2 cm of other major mediastinal structure (aorta, heart, trachea, pericardium, superior vena cava, pulmonary artery, esophagus, vertebra's body or spinal canal).
2. Patient has a lung lesion located less than 1 cm from the pleura or fissure
3. Patient has a lung cancer lesion \>2cm in diameter, for the expansion cohort lesion \>2-3 cm
4. Patient has cytologic or histologic evidence of nodal disease
5. Tumor invades major vessels
6. Prior exposure to VTP or PDT treatments
7. Pregnant or breastfeeding women
8. Receiving any other investigational treatment
9. Co-morbidities:

   1. Baseline hypoxia with O2 saturation \<92% on 2L NC or more of oxygen
   2. New York Heart Association (NYHA) stage III/IV heart failure
   3. Unstable coronary artery disease or MI within the last 6 months
   4. Uncontrollable clinically serious arrhythmia
   5. Decompensated/clinically worsening interstitial lung disease or obstructive lung disease.
   6. Unstable cerebrovascular or peripheral vascular disease
   7. Inability to stop anticoagulation or anti-platelet therapy peri-procedure
   8. Evidence of clinically active infection requiring systemic (any route) antibiotic therapy. All prior infections must have resolved following optimal therapy.
   9. Patient has any acute or chronic condition assessed as clinically significant by Investigator which may preclude bronchoscopy procedure
   10. History of medical or psychiatric disease which, in the view of the investigator, would preclude safe treatment or acceptable study compliance
   11. Known severe pulmonary hypertension (mean pulmonary arterial pressure ≥ 50 mmHg)
10. Patient has a cancer diagnosis with active disease requiring further cancer therapy.
11. Patient has had major surgery within the last 4 weeks.
12. Patient has porphyria or hypersensitivity to padeliporfin or porphyrin-like compounds or to any of its excipients.

Primary outcomes:
measure: Safety of robotic assisted bronchoscopic Padeliporfin VTP ablation
timeFrame: Day 30
measure: Feasibility of robotic assisted bronchoscopic Padeliporfin VTP treatment
timeFrame: Day 1
measure: Evaluate Maximum Tolerated light Dose and/or RP2D of Padeliporfin VTP ablation
timeFrame: Day 14
Secondary outcomes:
measure: Evaluation lung surgery feasibility
timeFrame: Day 5-21
measure: Evaluation of the ablation area
timeFrame: 2 days post Padeliprofin VTP
Other outcomes:
Locations:
city: Baltimore
country: United States
facility: Johns Hopkins University School of Medicine
state: Maryland
Study officials:
affiliation: Johns Hopkins University
name: Lonny Yarmus, MD
role: PRINCIPAL_INVESTIGATOR
References: