Clinical trial NCT06189911: Perioperative Blood Transfusion in Open Liver Resection
Official title: The Risk Factors for Perioperative Blood Transfusion in Open Liver Resection, a Retrospective Cohort Study Development of a Transfusion Scoring System to Predict the Requirement for Perioperative Blood Transfusion in Open Liver Resection
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Blood Loss, Postoperative
Keywords: liver resection
risk factors
blood transfusion
scoring system
Lead sponsor: Chiang Mai University
Sponsor class: OTHER
First posted: 2024-01-05
Enrollment: 1201
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All adult patients who underwent an elective open liver resection in our specialized hepato-biliary center from January 2006 through December 2017

Brief summary: This observational study is specifically designed to identify the pre-operative risk factors that significantly contribute to perioperative packed red cell transfusions in open liver resection procedures.

The main question it aims to answer are:

1. What are the risk factors of peri-operative blood transfusion in open liver resection procedures
2. What are the difference outcomes between patients who receive blood transfusion and the other group.

Researcher will compare perioperative factor and post operative outcomes between transfused and non-transfused group

Detailed description: After approval of the study protocol from the institutional review board of Chiangmai University (Approval number: ANE-2564-08020), we performed a retrospective review of all patients who underwent an elective open liver resection in our specialized hepato-biliary center from January 2006 through December 2017. This retrospective inquiry comprised 808 patients.

The data was systematically retrieved from electronic medical records. Baseline characteristics including age, gender, body mass index (BMI), co-morbidity, American Society of Anesthesiologists (ASA) classification, diagnosis, hepatitis profile, Child-Pugh classification, cirrhosis, the largest tumor size, previous liver resection, and pre-operative laboratory investigations were collected.

The following intra-operative data were collected: type of liver resection, hilar resection, vascular reconstruction, volume and type of fluid administration, estimated blood loss, packed red cell and blood product transfusion, and operation time. The definitions of liver resection and the type of hepatectomy were aligned with the anatomic classification of the Brisbane 2000 Terminology

Eligibility criteria: Inclusion Criteria:

* All genders age above 18 year old who underwent open liver resection from 2006-2017
* Elective open liver resection

Exclusion Criteria:

* Patients who death during the course of a surgical operation

Primary outcomes:
measure: the pre-operative risk factors of perioperative packed red cell transfusions in open liver resection procedures.
timeFrame: the transfusion of packed red cells during the operation and 48 hours after surgery
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Chiang Mai University
name: Warangkana Lapisatepun, M.D.
role: PRINCIPAL_INVESTIGATOR
References: