louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04179097: Photoplethysmographic Dichrotic Notch Reflexes Systemic Hemodynamics
Official title: Dichrotic Notch Positioning in Finger Photoplethysmography Waveform Reflex Systemic Vascular Resistance
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Vascular Diseases
Keywords: Doppler
Photoplethysmography
Lead sponsor: Hospital Privado de Comunidad de Mar del Plata
Sponsor class: OTHER
First posted: 2019-11-26
Enrollment: 15
Sex: ALL
Minimum age (years): 20
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients undergoing regional anesthesia (brachial plexus block) for upper limb surgeries

Brief summary: Changes in the vascular tone of anesthetized patients is common and cause hemodynamic problems. The investigators have previously demonstrated that the shape of the pulse oximetry waveform (photoplethysmography) is closely related to the changes observed in systemic vascular resistence. The main change in pulse waveform is based to the dichrotic notch position. The present study was designed to determine if the dichrotic notch position is related to a local or a systemic change in the vascular tone.

Detailed description: This is a prospective and observational study designed to determine if the changes observed in finger photoplethysmographic waveform of surgical patients is related to a local or a sistemic changes in the vascular tone. The investigators will studied 15 patients undergoing regional brachial plexus anesthesia for upper limb surgeries. Photoplethysmography will be continuously recorded in the thumb of the tested hand (anesthetized hand) and in the thumb of the control, opposite hand. Duplex color and power Doppler will measure flow in the both brachial arteries and in the aorta (supraesternal view). The contour analysis of both, photoplethysmogram and arterial flow velocities will be analyzed, correlated and compared.

Eligibility criteria: Inclusion Criteria:

* Written Inform Consent
* Programmed surgery
* Supine position

Exclusion Criteria:

* Emergency surgery
* Peripheral vascular diseases

Primary outcomes:
measure: Analysis in the position of the dichrotic notch between photoplethysmogram and spectral Doppler waveforms.
timeFrame: 4 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Mar del Plata
country: Argentina
facility: Cecilia M. Acosta
state: Buenos Aires
city: Mar del Plata
country: Argentina
facility: Hospital Privado de Comunidad
state: Buenos Aires
Study officials:
affiliation: Hospital Privado de Comunidad
name: Gerardo Tusman, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02400697: Placental Transfusion Project for Preterm Infants
Official title: Placental Transfusion in Preterm Infants Born at Less Than 34 Weeks of Gestation … Role of "Delayed" Cord Clamping and Umbilical Cord Milking
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Intraventricular Hemorrhage
Sepsis
Necrotizing Enterocolitis
Lead sponsor: Indiana University
Sponsor class: OTHER
First posted: 2015-03-27
Enrollment: 2856
Sex: ALL
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Preterm infants less than 30 weeks gestation or less than 1500 grams and/or preterm infants 30 weeks to less than 34 weeks gestation.

Brief summary: The American College of Obstetrics and Gynecology, American Academy of Pediatrics and the World Health Organization have recently published recommendations related to placental transfusions in preterm infants. This project will review outcomes of preterm infants following a quality improvement implementation process in several delivery centers in Indiana. Centers involved in this project are also part of the Indiana Vermont Oxford Network (IRB#1003-84). Data is recorded for that network and the investigators site will be reviewing that data every 3 months from infants who have completed the Vermont Oxford Network collection. This project will specifically look at the incidence of intraventricular hemorrhage, necrotizing entercolitis, periventricular leukomalacia, sepsis and death following the implementation of the ACOG recommendations.

Detailed description: Centers involved in this project are also part of the Indiana Vermont Oxford Network. Data is recorded for that network and the investigators site will be reviewing that data every 3 months from infants who have completed the Vermont Oxford Network collection. This project will specifically look at the incidence of intraventricular hemorrhage, necrotizing entercolitis, periventricular leukomalacia, sepsis and death following the implementation of the ACOG recommendations.

Eligibility criteria: Inclusion Criteria:

* Preterm infants born at participating hospital who are less than 30 weeks gestation or less than 1500 grams and/or preterm infants 30 weeks to less than 34 weeks gestation

Exclusion Criteria:

* None

Primary outcomes:
measure: Decrease in common complications of preterm birth
timeFrame: 3 years
Secondary outcomes:
Other outcomes:
Locations:
city: Indianapolis
country: United States
facility: Riley Hospital for Children
state: Indiana
Study officials:
affiliation: Indiana University
name: William Engle, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06099405: Yoga Training and Retinal Vasculature
Official title: The Impact of Yoga Training Protocols on Cognition, Aerobic, and Neuromuscular Performances, and Retinal Microvasculature and Microcirculation in Older Persons.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cognitive Change
Lead sponsor: University of Miami
Sponsor class: OTHER
Collaborators: name: McKnight Brain Research Foundation
First posted: 2023-10-25
Enrollment: 34
Sex: ALL
Minimum age (years): 60
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will compare the impact of a novel high-speed, cued yoga program to a standard yoga program on retinal microvasculature, cognition and neuromuscular function.


Eligibility criteria: Inclusion Criteria:

1. 60-90 years of age;
2. Montreal Cognitive Assessment (MoCA) \> 23
3. no memory loss complaints

Exclusion Criteria:

1. uncontrolled cardiovascular or neuromuscular diseases that prevent participation in a training program;
2. cerebrovascular disease;
3. documented HIV infection or other immunodeficiency syndrome;
4. any systemic inflammatory or autoimmune conditions such as rheumatoid arthritis, systemic lupus erythematosus, or other serious concomitant medical illness;
5. a history of ocular surgeries (except for cataract surgery more than 6 months ago) or other ocular diseases;
6. bilateral moderate or severe cataracts;
7. refractive errors of myopia, hyperopia and/or astigmatism more than 6.0 Diopters

Primary outcomes:
measure: Changes in Retinal measured in microliters per second (ul/s)
timeFrame: Baseline, 24 weeks
measure: Changes in Retinal vascular biomarkers
timeFrame: Baseline, 24 weeks
measure: Changes in the Hopkins Verbal Learning Test
timeFrame: Baseline, 24 weeks
measure: Changes in Executive Function
timeFrame: Baseline, 24 weeks
measure: Changes in the Six-Minute Walk Test
timeFrame: Baseline, 24 weeks
measure: Changes in the Timed Up and Go
timeFrame: Baseline, 24 weeks
measure: Changes in One repetition Maximum Strength
timeFrame: Baseline, 24 weeks
measure: Changes in Neuromuscular Power Testing
timeFrame: Baseline, 24 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Coral Gables
country: United States
facility: Laboratory of Neruomuscular Research and Active Aging
state: Florida
Study officials:
affiliation: University of Miami
name: Joseph F. Signorile, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03279705: The efﬁcacy of the Integrated Water Jet Channel Colonoscopy in Water Exchange Method
Official title: Division of Gastroenterology, Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Colonoscopy
Colon Disease
Keywords: water exchange
water jet channel colonoscopy
colonoscopy
cecal insertion time
adenoma detection rate
Lead sponsor: Dalin Tzu Chi General Hospital
Sponsor class: OTHER
First posted: 2017-09-12
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: A total of 120 patients were allocated into one of two groups by computerized randomization. In group A (Two-channel group), clear water was infused through the water jet channel and dirty water was sucked form the accessy channel. In group B (One-channel group), water exchange was done by using the accessory channel for both infusing and suctioning of water.
Primary purpose: DIAGNOSTIC

Brief summary: This prospective randomized controlled trial compared integrated water jet channel colonoscopy with traditional accessory channel colonoscopy in cecal insertion time among patients undergoing WE method colonoscopy.

Detailed description: When the WE method colonoscopy were done with the accessory channel for both infusing and suctioning of water. The water had to be suctioned or infused alternatively and increaed the insertion time.

With the new designed endoscopy that integrated a separate water jet channel for infusing water, infusing and suctioning of water can be done at the same time. Besides, water jet pumping system could provide a powerful jet to help us open the collapse lumen and keep an appropriate distance between the mucosa and the lens, thus preventing loss of visualization. It will help the colonoscopist to find the way during insertion.

Eligibility criteria: Inclusion Criteria:

* Underwent fully sedative colonoscopy with WE method in the outpatient department

Exclusion Criteria:

* Age \< 18 years old or \> 80 years old
* Without standard colon preparation
* Allergy to meperidine or propofol
* With a history of partial colectomy
* Refusal to provide written informed consent.

Primary outcomes:
measure: cecal insertion time
timeFrame: 2 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
Study officials:
affiliation: Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation
name: Yu-Hsi Hsieh
role: STUDY_DIRECTOR
References:
citation: Tseng CW, Koo M, Hsieh YH. Cecal intubation time between the use of one-channel and two-channel water exchange colonoscopy: A randomized controlled trial. J Gastroenterol Hepatol. 2020 Sep;35(9):1562-1569. doi: 10.1111/jgh.15043. Epub 2020 Apr 6.
Clinical trial NCT06714305: Comparison of Effectiveness of Hand Versus Rotary Instrumentation in Pulpectomy of Primary Second Molar Teeth.
Official title: Comparison of Effectiveness of Hand Versus Rotary Instrumentation in Pulpectomy of Primary Second Molar Teeth.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Irreversible Pulpitis (toothache)
Lead sponsor: Shaheed Zulfiqar Ali Bhutto Medical University
Sponsor class: OTHER
First posted: 2024-12-03
Enrollment: 60
Sex: ALL
Minimum age (years): 6
Maximum age (years): 11
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To provide an effective technique for pulpectomy in primary second molar teeth in pakistani population, local studies are required. No local studies have been done so far and limited number of international in vivo studies have been conducted previously. Hence this study will evaluate the effectiveness of this technique in pakistani population. If results of this study will be significant in favor of this technique, it will be applied with confidence in same population. There will be better compliance of patients as procedure will be done in single visit.


Eligibility criteria: Inclusion Criteria:

1. Children of both genders having age 4-6.5 years
2. Children having signs and symptoms of irreversible pulpitis in their second primary molar teeth on clinical examination as per operational definition.

Exclusion Criteria:

1. Children having previously accessed pulpectomy assessed clinically and on periapical radiographs.
2. Children having acute/chronic abcesses in teeth under consideration seen clinically.
3. Children having furcal or periapical radiolucency around teeth under consideration seen on periapical radiograph.
4. Diabetic, haemophilic or medically compromised children found on history
5. Children who fail to attend appointments.

Primary outcomes:
measure: To compare the effectiveness of manual versus rotary instrumentation for pulpectomy in primary second molar teeth irreversible pulpitis
timeFrame: immediately after obturation
Secondary outcomes:
Other outcomes:
Locations:
city: Multan
country: Pakistan
facility: Nishter Institute of Dentistry
state: Punjab
Study officials:
References:
Clinical trial NCT02413905: Characterizing the Gut Microbiota Alteration Associated With Severe Acute Malnutrition
Official title: Characterizing the Gut Microbiota Alteration Associated With Severe Acute Malnutrition
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Severe Malnutrition
Malnutrition
Infant Nutrition Disorders
Child Nutrition Disorders
Kwashiorkor
Marasmus
Lead sponsor: Institut Hospitalo-Universitaire Méditerranée Infection
Sponsor class: OTHER
First posted: 2015-04-10
Enrollment: 100
Sex: ALL
Maximum age (years): 59
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Children from Niamey and Dakar, Senegal

Brief summary: The investigators performed two case-control studies in Niger and Senegal analysing fecal microbiota to characterize the specificity of the gut microbiota alteration associated with severe acute malnutrition (SAM).

Detailed description: Fecal samples of cases (severe acute malnutrition (SAM) ascertained according to the WHO definition) and controls (asymptomatic healthy children ascertained by clinical and anthropometric criteria) were analysed by v3v4 16S rRNA sequencing, redox and pH measurement and using specific polymerase chain reaction targeting Methanobrevibacter smithii and Bacteroides thetaiotaomicron. Based on the literature and oxydative stress reported in SAM, the investigators tested if the proportion of aerotolerant prokaryotes is increased among gut prokaryotes enriched in SAM in comparison to prokaryotes enriched in controls. The investigators further linked this to fecal redox potential and assessed the total number of bacteria in feces by flux cytometry.

Eligibility criteria: Inclusion criteria:

* Children aged 0-59 months of varying nutritional status from Niamey (Niger) and Dakar (Senegal).

Exclusion Criteria:

* Absence of parent or patient consent, antibiotic administration \<2 months before stool collection and insufficient fecal amount. Exclusion criteria for controls included any form of malnutrition, presence of fever, acute respiratory infection (cough), acute or chronic diarrhea in the previous 4 weeks. Symptoms and complications of malnutrition (cough, fever, diarrhoea, vomiting) nor other form of malnutrition (moderate to severe stunting and underweight) were not a reason of exclusion for cases since they are considered as direct consequence and part of severe acute malnutrition.

Primary outcomes:
measure: Aerotolerant Odds ratio (AOR)
timeFrame: 1 day (Participants were not followed as this is a case-contol study only clinical and anthropometric data and fecal samples were collected the day of inclusion)
Secondary outcomes:
Other outcomes:
Locations:
city: Niamey
country: Niger
facility: Hopital National
city: Dakar
country: Senegal
facility: Clinic Notre Dame de L'Esperance, Thiaroye
Study officials:
affiliation: Assistance publique des Hôpitaux de Marseille
name: Matthieu Million
role: STUDY_CHAIR
References:
Clinical trial NCT02092805: rTMS as a Treatment of Visceral Pain Secondary to Malignancy
Official title: Repetitive Transcranial Magnetic Stimulation in Visceral Pain Secondary to Malignancy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Malignancy
Keywords: VAS
VDS
HAM-D
Visceral pain
Malignancy
rTMS
Motor cortex
Analgesia
Dynorphin
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2014-03-20
Enrollment: 34
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to assess the efficacy of rTMS over primary motor cortex in patients suffering from malignant visceral pain. Thirty four patients were included in the study. They are divided randomly into 2 groups using closed envelop as real rTMS group and sham group. Real rTMS over the hand area of motor cortex (20 Hz, 10 trains with inter train interval 30 second with total pulses 2000, intensity 80% of motor threshold) every day for ten consecutive days (5 days/week) and the coil elevated and angled away from the head as sham stimulation. Patients were evaluated by verbal descriptor scale (VDS), visual analog scale (VAS), and Hamilton rating scale for depression (HAM-D) at the baseline, after 1st, 5th, 10th session, 15 day and 1 month after end of sessions. Serum human dynorphin (Dyn) level was measured at baseline, 5th and 10th session.


Eligibility criteria: Inclusion Criteria:

* All patients within age group 18-65 years with malignant visceral pain resistant to medical treatment for at least 2 months or associated with significant adverse effect from medication was involved in this study.

Exclusion Criteria:

* We excluded patients with intracranial metallic devices or with pacemakers or any other device. We also excluded those with extensive myocardial ischemia, unstable angina and those known to have epilepsy.

Primary outcomes:
measure: Visceral pain improvement
timeFrame: one month
Secondary outcomes:
measure: Reduction of depression manifestation
timeFrame: one month
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01255605: Impact of IPT With Sulfadoxin Pyrimetamin on Pregnant Women and Their Babies Outcomes in Peri-urban Areas of Bobo-Dioulasso(Burkina Faso)
Official title: Impact of Intermittent Preventive Treatment (IPT) With Sulfadoxine-pyrimethamine (SP) on the Morbidities Associated With Malaria in Pregnant Women and Newborns in Peri-urban Areas of Bobo-Dioulasso, 5 Years After Its Adoption by the National Program for Fight Against Malaria in Burkina Faso.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Malaria, Pregnancy
Keywords: Intermittent preventive treatment with sulfadoxin-pyrimethamine
in Bobo-Dioulasso peri-urban areas, 5 years after its implementation
Burkina Faso.
Lead sponsor: Université Polytechnique de Bobo-Dioulasso
Sponsor class: OTHER
First posted: 2010-12-07
Enrollment: 772
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Our study population is constitued by pregnant women coming for antenatal care or delivery in two peripheral heath facilities of Bobo-Dioulasso(Lafiabougou and Secteur 24).

Brief summary: The purpose of this is to determine the impact of intermittent preventive treatment (IPT) with sulfadoxine-pyrimethamine (SP) on the morbidities associated with malaria in pregnant women and newborns in rural peri-urban areas of Bobo-Dioulasso, 5 years after its implemented.

Detailed description: Malaria in pregnant women is a crucial issue in Burkina Faso. Faced with this problem, a strategy based on the use of treated nets and intermittent preventive treatment (IPT) based on sulfadoxine-pyrimethamine (SP) was adopted in 2005. Five years after its implementation, the investigators will check whether this strategy is still effective in the preventing maternal and congenital malaria on the one hand and maternal anemia, low birth weight and prematurity on the other hand.

Eligibility criteria: Inclusion Criteria:

* Residing in the health area of Lafiabougou or secteur 24
* Having agreed to give free and informed consent

Exclusion Criteria:

* Bleeding from during the pregnancy
* eclampsia

Primary outcomes:
measure: Peripheral and placental malaria
timeFrame: Peripheral malaria : at antenatal clinics and at delivery. Placental malaria: at delivery
Secondary outcomes:
measure: Maternal anemia, congenital malaria,low birth weight, prematurity.
timeFrame: Maternal anemia: at antenatal clinics and at delivery. Congenital malaria: at delivery. Low birth weight: at delivery. Prematurity: at delivery.
Other outcomes:
Locations:
city: Bobo-Dioulasso
country: Burkina Faso
facility: Institut Supérieur des Sciences de la Santé/Université Polytechnique de Bobo-Dioulasso
state: Houet
Study officials:
affiliation: Centre MURAZ Research Institute
name: Mamoudou Cisse, MD
role: PRINCIPAL_INVESTIGATOR
References: