louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05285111: Pilot of Reconnecting to Internal Sensations and Experiences in Undergraduates
Official title: Pilot of Reconnecting to Internal Sensations and Experiences in Undergraduates
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Suicidal Ideation
Eating Disorder Symptom
Lead sponsor: Auburn University
Sponsor class: OTHER
First posted: 2022-03-17
Enrollment: 200
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Project RISE is a randomized control trial. The intervention consists of four modules that focus on multiple aspects of interoception including: body awareness, body sensations/movement, eating, health and self-care, emotional awareness, and understanding the self in relation to others. The comparator condition is called "Health Habits" and is matched for time and attention; participants complete modules related to healthy habits such as financial planning, hygiene, stretching, and healthy eating. Variables of interest include self-report measures of interoception, eating pathology, suicidality, physiological measures of interoception (electrocardiograph; ECG; pain tolerance measured via algometer), and an implicit association test (IAT) with death and life stimuli (meant to measure implicit associations with suicidality). The population will be college students, with current or past suicidality or low interoception.


Eligibility criteria: Inclusion Criteria:

* Low interoceptive awareness
* History of suicidal ideation or attempt
* 18 or older

Exclusion Criteria:

\*Below the age of 18

Primary outcomes:
measure: Multidimensional Assessment of Interoceptive Awareness
timeFrame: within one week of Post-test
measure: Treatment acceptability
timeFrame: within one week of Post-test
Secondary outcomes:
measure: Depression Screening Inventory-Suicidality Subscale
timeFrame: within one week of Post-test
measure: Eating Disorder Examination Questionnaire
timeFrame: within one week of Post-test
measure: Heartbeat perception task
timeFrame: within one week of Post-test
measure: Brief Symptom Inventory
timeFrame: within one week of Post-test
Other outcomes:
Locations:
city: Auburn
country: United States
facility: Auburn University
state: Alabama
Study officials:
References:
Clinical trial NCT05198011: Three-Dimensional Printed Customized Titanium Mesh for Mandibular Augmentation
Official title: Mandibular Ridge Augmentation Using Three-Dimensional Printed Model for Customization of Titanium Mesh
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Alveolar Bone Loss
Lead sponsor: Alexandria University
Sponsor class: OTHER
First posted: 2022-01-20
Enrollment: 14
Sex: ALL
Minimum age (years): 40
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Completely or partially edentulous patients suffer from resorption of the alveolar bone, they always seek rehabilitation which becomes challenging. Alveolar ridge augmentation is widely done now to offer these patients functional and esthetic restoration. Many techniques have been proposed to obtain good results of ridge augmentation. Titanium Mesh (TiMe) is widely used, also digital and computer-guided surgery now plays an important role to improve the techniques and results in ridge augmentation procedures.


Eligibility criteria: Inclusion Criteria:

* Patients will have a posterior mandibular atrophic ridge
* Distance between the crest of the ridge and the superior border of the inferior alveolar canal will be from 5 mm to 7 m
* Adequate inter-arch space

Exclusion Criteria:

* Patients who have any uncontrolled systemic disease contraindicated to oral surgery ( Diabetes, hypertension, and patients under chemotherapy treatment )
* Patients who have any relevant bone disease.
* Patients who are smokers

Primary outcomes:
measure: Change in bone volume
timeFrame: at baseline and 6 months
measure: Operation time
timeFrame: During the procedure
Secondary outcomes:
Other outcomes:
Locations:
city: Alexandria
country: Egypt
facility: Alexandria Faculty of Dentistry
Study officials:
References:
Clinical trial NCT02419911: Comparison FloShield Air System Versus Clearify Visualization System (D-HELP)
Official title: Prospective, Randomized Comparison of the Use of FloShield Air System Versus Clearify Visualization System (D-HELP) During Laparoscopic Surgery to Evaluate the Operative Interruption for Lens Cleaning
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Laparoscopic Surgery
Keywords: gastrointestinal
gynecologic
urologic
bariatric
laparoscopic surgery
Lead sponsor: Minimally Invasive Devices, Inc.
Sponsor class: INDUSTRY
First posted: 2015-04-17
Enrollment: 62
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: This is a post market, prospective, comparison study of the use of the FloShield Air System versus Clearify™ Visualization System (D-HELP) during laparoscopic surgery.

Detailed description: This is a post market, prospective, comparison study of the use of the FloShield Air System versus Clearify™ Visualization System (D-HELP) during laparoscopic surgery. The study will be randomized across two groups, one group will evaluate laparoscopic lens cleaning with D-HELP during laparoscopic surgery and the second group will evaluate laparoscopic lens cleaning using the FloShield Air System during laparoscopic surgery. Each surgery will be captured on video. Study parameters will be evaluated through review of each video by an independent evaluator.

Eligibility criteria: Inclusion Criteria:

* Female or Male;
* 18 years of age or older;
* Patient scheduled for gastrointestinal, gynecologic, urologic or bariatric laparoscopic surgery under the care of the study investigator;
* Suitable candidate for surgery

Exclusion Criteria:

* Unfit for surgery: concomitant disorders incompatible with the study or surgery (at the discretion of the investigator);
* Use of Surgiquest AirSeal®;
* Use of humidified insufflation

Primary outcomes:
measure: number of Laparoscope removals during surgery
timeFrame: 0.5hr - 6hr
Secondary outcomes:
Other outcomes:
Locations:
city: South Miami
country: United States
facility: South Miami Hospital
state: Florida
city: Las Vegas
country: United States
facility: Centennial Hills Medical Center
state: Nevada
city: Cincinnati
country: United States
facility: University of Cincinnati
state: Ohio
Study officials:
affiliation: President and CEO
name: Wayne Poll, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT05858593: Positive Youth Development in the Metaverse
Official title: Positive Youth Development in the Metaverse - Development of a Virtual Reality Afterschool Program for Middle Childhood Youth
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy
Healthy Lifestyle
Childhood ALL
Behavior, Child
Keywords: virtual reality
positive youth development
afterschool program
Lead sponsor: University of Georgia
Sponsor class: OTHER
First posted: 2023-05-15
Enrollment: 31
Sex: ALL
Minimum age (years): 9
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: This pilot study aims to leverage VR's capacity to easily replicate content and allow for multiple users to share the same space and engage in activities as if they're meeting in person. Integrating VR into afterschool programs will allow youth to receive more consistent programming content, even when they are unable to travel to the physical location for the in-person meetings.

Detailed description: This pilot study aims to leverage VR's capacity to easily replicate content and allow for multiple users to share the same space and engage in activities as if they're meeting in person. Integrating VR into afterschool programs will allow youth to receive more consistent programming content, even when they are unable to travel to the physical location for the in-person meetings. It will also empower youth to engage with the afterschool program at their own pace by providing a safe space to learn and practice their socioemotional skills. Implemented at scale, these benefits of a VR-integrated afterschool program will be able to address the issues of health inequity head on by expanding access to high quality afterschool content without incurring high operating costs. The results from this pilot study will provide a critical foundation to apply for an extramurally funded clinical trial to demonstrate the efficacy of a VR-integrated afterschool program on youth mental wellbeing.

Aim 1: Determine feasibility of a VR-integrated afterschool program where youth can access the VR content on their own at home.

Aim 2: Test the hypothesis that complementing the in-person afterschool program with VR will increase a) engagement and b) socioemotional competencies in youth.

Aim 3: Test the hypothesis that youth will demonstrate better mental wellbeing when the in-person afterschool program is complemented with VR.

Eligibility criteria: Inclusion Criteria:

* Children enrolled in the Chess \& Community program
* Between the ages of 9-17
* The parent/primary caregiver of these children

Exclusion Criteria:

* Children who are unable to wear a VR headset will not be recruited

Primary outcomes:
measure: Self-regulation
timeFrame: One-time assessment post-treatment (at 8 weeks)
measure: Mental well-being
timeFrame: One-time assessment post-treatment (at 8 weeks)
Secondary outcomes:
measure: Engagement
timeFrame: 8 weeks
Other outcomes:
Locations:
city: Athens
country: United States
facility: Athens Chess & Community
state: Georgia
Study officials:
References:
Clinical trial NCT06232993: Management of Myofascial Pain in Children With Sleep Bruxism
Official title: Comparative Evaluation of the Effects of Kinesio Tape and Occlusal Splint Use in the Management of Myofascial Pain in Children With Sleep Bruxism: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Bruxism
Lead sponsor: Adiyaman University
Sponsor class: OTHER
First posted: 2024-01-31
Enrollment: 57
Sex: ALL
Minimum age (years): 6
Maximum age (years): 11
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study compared the effectiveness of Kinesio tape and occlusal splint application in improving sleep quality and reducing myofascial pain in children with sleep bruxism.

Detailed description: Forty-seven pediatric patients with sleep bruxism symptoms were randomly assigned into 3 groups for treatment: Kinesio tape group (KT), Occlusal splint group (OS), and Exercise group (EG). The following assessments were made in all 3 groups, before the treatment and at the end of the 1st and 5th week: Wong-Baker Faces Pain Scale (WBFPS), measurement of maximum mouth opening, assessment of pressure pain threshold of the bilateral masseter and temporal muscles, and evaluation of temporal and masseter muscle thickness by ultrasonography.

Eligibility criteria: Inclusion Criteria:

* Children aged 6-11 years \[1\] presented to the clinic and had at least one symptom of sleep bruxism,
* Children and parents who agreed to participate in the study,
* Children who have not been treated for sleep bruxism before,
* Children who can cooperate,
* Children without maxillofacial trauma.

Exclusion Criteria:

* • Children with psychiatric/neurological/systemic disorders,

  * Children with a history of allergies or asthma,
  * Children using orthodontic appliances,
  * Children taking any medication,
  * Children with dental abscess or fistula mouth,
  * Children using a fixed or removable placeholder appliance.

Primary outcomes:
measure: Wong-Baker Faces Pain Scale
timeFrame: Applied before, 1 week after, and 5 weeks after the treatment
Secondary outcomes:
Other outcomes:
Locations:
city: Adıyaman
country: Turkey
facility: Adiyaman Universty
Study officials:
affiliation: Adıyaman U
name: Kamile N Tozar
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00338793: Corticosteroids in the Treatment of Tuberculous Pleurisy
Official title: A Multicenter, Placebo-Controlled, Double-Blind, Randomized Clinical Trial to Evaluate the Efficacy and Safety of Corticosteroids for Treatment of Patients With Tuberculous Pleurisy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Tuberculous Pleurisy
Keywords: Tuberculosis;
Pleural effusion;
Corticosteroids.
Lead sponsor: Guangxi Medical University
Sponsor class: OTHER
Collaborators: name: National Natural Science Foundation of China
name: Ministry of Education, China
name: Bureau of Science and Technology of Guangxi Province, China
First posted: 2006-06-20
Enrollment: 1500
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Tuberculous pleurisy is associated with inflammation and fibrosis. Adjunctive corticosteroids are used for tuberculous pleurisy because their anti-inflammatory effect is thought to minimise pleural reactivity and thereby reduce residual pleural thickening. The purpose is to evaluate the efficacy and safety of oral prednisolone for treatment of adult patients with tuberculous pleurisy.


Eligibility criteria: Inclusion Criteria:

* Signed written informed consent;
* Presented with clinical features suggesting pleural tuberculosis;
* Had not previously received treatment or prophylaxis for tuberculosis;
* Had not recently received treatment with glucocorticoids;
* Were not pregnant or breast-feeding.

Exclusion Criteria:

* Failed to complete the screening procedures;
* Were seropositive for HIV
* Tuberculous meningitis;
* Had risk factors for serious steroid-related adverse events (a history of diabetes or positive urine glucose, a history or clinical finding of hypertension, or a history of peptic ulcer disease or mental illness);
* Standard doses of antituberculosis drugs could not be used (as in participants with concurrent liver disease)
* Psychiatric illness;
* Alcoholism.

Primary outcomes:
measure: Death
measure: Presence of pleural thickening
measure: Pulmonary function at completion of treatment
measure: Adverse drug effects
Secondary outcomes:
measure: Improvement in clinical symptoms and signs (such as pleuritic chest pain, temperature)
measure: Reabsorption of pleural effusion
measure: Failure rate at the end of treatment
Other outcomes:
Locations:
city: Nanning
country: China
facility: Huan-Zhong Shi
state: Guangxi
Study officials:
affiliation: Institute of Respiratory Diseases, First Affiliated Hospital, Guangxi Medical University, Nanning 530021, Guangxi, China
name: Huan-Zhong Shi, MD, PhD
role: STUDY_CHAIR
affiliation: Department of Respiratory Diseases, People's Hospital, Peking University, Beijing, China
name: Zhan-Cheng Gao, MD, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Department of Respiratory Diseases, First Affiliated Hospital, Shanghai Jiaotong University, Shanghai, China
name: Xin Zhou, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03467893: Evaluation of Rebound Effect After Withdrawal of Proton Pump Inhibitor in Geriatric Population
Official title: Evaluation of Rebound Effect After Withdrawal of Proton Pump Inhibitor After 8 Weeks of Treatment in Geriatric Population
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Proton Pump Inhibitor
Lead sponsor: Fondation Hôpital Saint-Joseph
Sponsor class: OTHER
First posted: 2018-03-16
Enrollment: 30
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patient admitted in Leopold Bellan post acute an rehabilitation institution.

Brief summary: Proton pump inhibitor are frequently used and are short term well tolerated ; but few studies show there are adverse event in long term prescription like fracture or pulmonary infection to Clostridum difficile. The fact is that multi medication in old patient increase the iatrogenic risk and decrease the medication compliance. The Proton pump inhibitor (PPI)are overused in this patient category.Several studies suggest the existence of a rebound effect when people were treated more than 8 weeks ; this effect seems to appear around 14 days after with hyperacidity symptoms.

But there are no studies about old patient. So in this context the aim of the study is to evaluate the prevalence of rebound effect occurence after the end of PPI 8 weeks treatment.


Eligibility criteria: Inclusion Criteria:

* patients hospitalized in post acute and rehabilitation service
* more than 65 years old
* PPI prescription more than 8 weeks

Exclusion Criteria:

* PPI prescription under 8 weeks
* PPI prescription for digestive haemorragy

Primary outcomes:
measure: Number of antacids used
timeFrame: Day 14 after end of treatment
Secondary outcomes:
Other outcomes:
Locations:
city: Paris
country: France
facility: Groupe Hospitalier Paris Saint Joseph
state: Ile-de-France
Study officials:
References:
Clinical trial NCT06915493: Blood Glucose Levels in Children During Anesthesia
Official title: Blood Glucose Levels in Children During Anesthesia: Incidence of Hypoglycemia During Anesthesia Induction and Its Relationship to Preoperative Fasting
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Fasting
Keywords: Pediatrics
Children
General anesthesia
Preoperative fasting
Fasting blood glucose
Hypoglycemia
Lead sponsor: Landspitali University Hospital
Sponsor class: OTHER
Collaborators: name: University of Iceland
First posted: 2025-04-08
Enrollment: 350
Sex: ALL
Minimum age (years): 1
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Convenience sample of children undergoing elective intervention under general anesthesia at Landspítali, the University Hospital of Iceland.

Brief summary: This cross-sectional study aims to investigate blood glucose levels in children during general anesthesia and explore the incidence of hypoglycemia after anesthesia induction in relation to preoperative fasting.

Blood glucose will be measured following anesthesia induction and prior to discontinuing the administration of the anesthetic agent.

Detailed description: This cross-sectional study aims to investigate blood glucose levels in children \< 18 years during general anesthesia, and explore the incidence of hypoglycemia after anesthesia induction in relation to preoperative fasting.

The purpose is to evaluate whether guidelines for shortening the preoperative fasting period of children at our hospital have resulted in a shorter fasting duration and prevalence of low blood glucose levels during anesthesia induction. Also to shed light on blood glucose levels during general anesthesia and its correlation with intravenous fluid management and administration of steroidal anti-emetics.

Blood glucose sampling will be obtained and measured following anesthesia induction and prior to discontinuing the anesthetic agent. If general anesthesia lasts longer than one hour, additional blood glucose analysis will be conducted one hour after the first measurement.

Eligibility criteria: Inclusion Criteria:

Children under 18 years of age who undergo intervention under general anesthesia. The parent or guardian understands and speaks Icelandic.

Exclusion Criteria:

Coexisting disease or treatment that may affect fasting blood glucose level; Preoperative intravenous fluid administration; Beta-blockers; Insulin and corticosteroids, endocrine disorders, acute pain, and emergency interventions.

Primary outcomes:
measure: Serum blood glucose level
timeFrame: Immediately/within five minutes after anesthesia induction and prior to discontinuing the anesthesia administration.
Secondary outcomes:
Other outcomes:
Locations:
city: Reykjavik
country: Iceland
facility: Anesthesia Department Landspitali UH
Study officials:
affiliation: Landspitali, the University Hospital of Iceland and University of Iceland
name: Thorunn S Eliasdottir, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05819593: Evaluating Trends in Anaplastic Thyroid Cancer Patients' Clinical Study Experiences
Official title: A Critical Analysis of Anaplastic Thyroid Clinical Trials: Perspectives From Patient Experiences
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Anaplastic Thyroid Cancer
Keywords: anaplastic thyroid cancer
Lead sponsor: Power Life Sciences Inc.
Sponsor class: INDUSTRY
First posted: 2023-04-19
Enrollment: 500
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CROSSOVER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with anaplastic thyroid cancer who are actively considering participating in an observational clinical study, but have not yet completed enrollment and randomization.

Brief summary: Clinical trials can sometimes favor certain demographic groups. Additionally, there is limited research that delves into the factors that influence participation in clinical study, both positive and negative.

The goal is to identify the obstacles and challenges that prevent participation in anaplastic thyroid cancer clinical research, as well as the reasons for withdrawal or discontinuation.

Insights gained from this study will ultimately benefit those with anaplastic thyroid cancer who may be invited to participate in clinical research in the years to come.


Eligibility criteria: Inclusion Criteria:

* Diagnosed with anaplastic thyroid cancer
* Willing to comply with all study related procedures and assessments
* Capable of giving signed informed consent, which includes compliance with requirements and restrictions listed in the informed consent form (ICF) and in the protocol

Exclusion Criteria:

* No documented diagnosis of anaplastic thyroid cancer
* Any serious and/or unstable pre-existing medical disorders
* Pregnant or lactating woman

Primary outcomes:
measure: Number of anaplastic thyroid cancer patients who decide to enroll in a clinical study
timeFrame: 3 months
measure: Rate of anaplastic thyroid cancer patients who remain in a clinical study to completion
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Power Life Sciences Inc.
name: Michael B Gill
role: STUDY_DIRECTOR
References:
citation: Al-Jundi M, Thakur S, Gubbi S, Klubo-Gwiezdzinska J. Novel Targeted Therapies for Metastatic Thyroid Cancer-A Comprehensive Review. Cancers (Basel). 2020 Jul 29;12(8):2104. doi: 10.3390/cancers12082104.
citation: Saini S, Tulla K, Maker AV, Burman KD, Prabhakar BS. Therapeutic advances in anaplastic thyroid cancer: a current perspective. Mol Cancer. 2018 Oct 23;17(1):154. doi: 10.1186/s12943-018-0903-0.
citation: Ljubas J, Ovesen T, Rusan M. A Systematic Review of Phase II Targeted Therapy Clinical Trials in Anaplastic Thyroid Cancer. Cancers (Basel). 2019 Jul 4;11(7):943. doi: 10.3390/cancers11070943.