Clinical trial NCT03133949: Aortitis and Retroperitoneal Fibrosis: Evaluation of Diagnostic Criteria
Official title: Aortitis and Retroperitoneal Fibrosis: Evaluation of Diagnostic Criteria
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Idiopathic Aortitis
Retroperitoneal Fibrosis
Lead sponsor: Centre Hospitalier Universitaire, Amiens
Sponsor class: OTHER
First posted: 2017-04-28
Enrollment: 206
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients with idiopathic inflammatory aortitis or retroperitoneal fibrosis.

Three focus groups will be constituted:

Group 1: it will include all cases of non-idiopathic inflammatory aortitis followed in the participating centers over the last 15 years, Group 2: it will include patients with non-inflammatory aortic conditions (aneurysm, atheroma, annulo-ectasitic aortic disease).

Group 3: it will include patients without aortic pathology matched by age and sex, having a thoracoabdominal scanner or MRI in the participating centers.

Brief summary: Inflammatory aortitis probably represents a heterogeneous group, and the clinical experience accumulated over the last ten years, shared by the experts of the subject, is that the initial clinical, biological or radiological characteristics should make it possible to differentiate them and dismember the Nosological field.

This will be an essential first step before studying prognosis, risk factors, and therapeutic options.

The search for diagnostic criteria on a large series, similar to the study of classification of vascularites of the ACR in 1990, should make it possible to homogenize the diagnoses for the different teams working on the subject, and to begin work Collaborations, which alone can improve patient care in the future.


Eligibility criteria: Inclusion Criteria:

* Cases :

  * All cases of idiopathic aortitis and retroperitoneal fibrosis followed in participating centers over the past 15 years will be collected.
* Witnesses :

  * Group 1: non-idiopathic inflammatory aortitis: all cases of inflammatory aortitis (apart from idiopathic aortites and isolated retroperitoneal fibrosis) followed in the participating centers over the last 15 years will be collected.
  * Group 2: subjects with noninflammatory aortic disease, atheromatous type or annulo-ectasitic disease, matched by age and sex with cases. This group will be used to define the differential characteristics between idiopathic aortitis and noninflammatory aortic pathology.
  * Group 3: This group will include control subjects aimed at defining radiological normality criteria according to age and sex. As the images are machine-dependent, group 3 controls will be randomly selected from the radiology departments that have performed the scanner or MRI of the corresponding control.

Exclusion Criteria:

* Patients under 18 years of age

Primary outcomes:
measure: Analyze the management of patients with aortic and retroperitoneal fibrosis
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
city: Amiens
country: France
facility: CHU Amiens Picardie
state: Picardie
Study officials:
References: