Clinical trial NCT04541498: Impact of Air Pollution and Climate Changes on the Epidemiology of Cardiovascular Disease
Official title: Impact of Air Pollution and Climate Changes on the Epidemiology of Cardiovascular Disease
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pollution; Exposure
Acute Coronary Syndrome
Chronic Coronary Insufficiency
Particulate Matter Inhalation Injury
Cardiovascular Diseases
Cardiovascular Risk Factor
Keywords: Air pollution
Particulate Matter
Acute Coronary Syndromes
Cardiovascular Disease
Risk factors
Lead sponsor: Medical University of Bialystok
Sponsor class: OTHER
First posted: 2020-09-09
Enrollment: 150000
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: CASE_CROSSOVER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: In primary we focus on Podlaskie Voivodeship. The region is located in north-east Poland which is a developing country as well as one of the poorest regions of the EU. Within four national parks, the region is widely known as the Green Lungs of Poland, mainly due to large areas covered by forests, lack of factories, and relatively low industrialization.

Brief summary: Despite the fact that the topic of air pollution has been in focus of researchers for many years, there are no big studies that take up the matter of its influence on acute coronary, cerebral syndromes and CVD mortality in Europe. Taking into consideration the scarce number of surveys from Europe the investigators decided to analyze the impact of air pollution on cardiovascular diseases and CVD mortality in Poland.

Detailed description: Air quality and its impact on health was put in the spotlight since the infamous Great Smog of London. Since then, it became clear that adverse effects are serious and can no longer be ignored. According to the World Health Organization (WHO) estimations, in last year ambient air pollution caused 4,200,000 deaths worldwide. These statistics included a total of 29,165 deaths that were attributed to air pollution in Poland.

The vast of studies are conducted in highly polluted areas, in which patients are exposed to extreme concentrations like China oraz Indie. Taking into consideration the scarce number of surveys from Europe the investigators decided to analyze the impact of air pollution and cardiovascular diseases in Poland.

Data on morbidity and mortality were collected from the National Statistical Office in Poland. The data of air pollutions and gases were obtained from Voivodeship Inspectorate for Environmental Protection. The daily meteorological data were obtained from the Institute of Meteorology and Water Manageme

Eligibility criteria: Inclusion criteria:

- residents from analysed area.

Exclusion criteria

- none

Primary outcomes:
measure: Incidence of acute coronary syndromes
timeFrame: Through study completion, an average of 1 year
measure: Incidence of cardiovascular mortality
timeFrame: Through study completion, an average of 1 year
measure: Incidence of acute cerebral syndromes
timeFrame: Through study completion, an average of 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Białystok
country: Poland
facility: Department of Invasive Cardiology Medical University of Białystok 24A M. Skłodowskiej-Curie St.
Study officials:
affiliation: Medical University of Bialystok, Department of Invasive Cardiology
name: Lukasz Kuzma, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Kuzma L, Pogorzelski S, Struniawski K, Dobrzycki S, Bachorzewska-Gajewska H. Effect of air pollution on the number of hospital admissions for acute coronary syndrome in elderly patients. Pol Arch Intern Med. 2020 Jan 31;130(1):38-46. doi: 10.20452/pamw.15064. Epub 2019 Nov 19.
citation: Kuzma L, Pogorzelski S, Struniawski K, Bachorzewska-Gajewska H, Dobrzycki S. Exposure to air pollution-a trigger for myocardial infarction? A nine-year study in Bialystok-the capital of the Green Lungs of Poland (BIA-ACS registry). Int J Hyg Environ Health. 2020 Aug;229:113578. doi: 10.1016/j.ijheh.2020.113578. Epub 2020 Aug 3.
citation: Kuzma L, Struniawski K, Pogorzelski S, Bachorzewska-Gajewska H, Dobrzycki S. Gender Differences in Association between Air Pollution and Daily Mortality in the Capital of the Green Lungs of Poland-Population-Based Study with 2,953,000 Person-Years of Follow-Up. J Clin Med. 2020 Jul 23;9(8):2351. doi: 10.3390/jcm9082351.
citation: Kuzma L, Wanha W, Kralisz P, Kazmierski M, Bachorzewska-Gajewska H, Wojakowski W, Dobrzycki S. Impact of short-term air pollution exposure on acute coronary syndrome in two cohorts of industrial and non-industrial areas: A time series regression with 6,000,000 person-years of follow-up (ACS - Air Pollution Study). Environ Res. 2021 Jun;197:111154. doi: 10.1016/j.envres.2021.111154. Epub 2021 Apr 17.
citation: Rogalska E, Kurasz A, Kuzma L, Bachorzewska-Gajewska H, Dobrzycki S, Kozinski M, Sobkowicz B, Tomaszuk-Kazberuk A. Comparing Atrial-Fibrillation Validated Rapid Scoring Systems in the Long-Term Mortality Prediction in Patients Referred for Elective Coronary Angiography: A Subanalysis of the Bialystok Coronary Project. Int J Environ Res Public Health. 2022 Aug 21;19(16):10419. doi: 10.3390/ijerph191610419.