Clinical trial NCT04181671: Low Resistance Venous Blood Flow Restriction Training (LR-VBFRT) on Biceps Brachii Muscle Performance
Official title: Effects of Low Resistance Venous Blood Flow Restriction Training (LR-VBFRT) on Biceps Brachii Muscle Performance
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Muscle Weakness Condition
Keywords: Exercise Training
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2019-11-29
Enrollment: 40
Sex: MALE
Minimum age (years): 20
Maximum age (years): 28
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Both experimental and control groups will be treated at the same time following their respective protocols
Primary purpose: TREATMENT

Brief summary: Resistance training has been widely recognized as an effective stimulus for increasing skeletal muscle size and strength. This study intends to compare the effects of high resistance training without blood flow restriction and the low resistance training with blood flow restriction training on bicep muscle performance.

Detailed description: The study is Randomized Control Trail, which is being conducted in RIPHAH COLLEGE OF REHABILITATION SCIENCES. Sample size of 40 individual was calculated using Epitool with 95% confidence interval (CI) and power 80%. Individual will be screened out according to inclusion criteria. Individuals will be allocated randomly into two groups, 20 in high resistance training group and 20 in low resistance training with blood flow restriction group by sealed envelope method.

High resistance training will be use in control group.Low resistance with blood flow restriction training will be used in experimental group.

Assessment will be done on baseline 2-4 days prior to the intervention and after 8 weeks of training.

Data will be analyzed on SPSS version 21.

Eligibility criteria: Inclusion Criteria:

* Males
* Age: 20-28 year
* Body mass index: 18.5-24.9

Exclusion Criteria:

* Vascular Disease
* Upper Limb Pathology Requiring Surgical Intervention
* Upper Limb Musculoskeletal Issues
* Blood Pressure \>140/90
* Coronary Artery Disease
* Venous Thromboembolism
* Congenital Cardiac Diseases
* Syncope, Arrhythmias, Smokers
* Alcohol Use
* Supplements Intake
* whey Protein Intake

Primary outcomes:
measure: Muscle strength
timeFrame: Baseline
measure: Muscle strength
timeFrame: Post 6 weeks
measure: 1 Repetition maximum
timeFrame: Baseline
measure: 1 Repetition maximum
timeFrame: Post 6 weeks
measure: Bicep Muscle power
timeFrame: Baseline
measure: Bicep Muscle power
timeFrame: Post 6 weeks
measure: Bicep muscle endurance testing
timeFrame: Baseline
measure: Bicep muscle endurance testing
timeFrame: Post 6 weeks
measure: Arm circumference
timeFrame: Baseline
measure: Arm circumference
timeFrame: Post 6 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Rawalpindi
country: Pakistan
facility: RCRAHS Potohar campus
state: Punjab
Study officials:
affiliation: Riphah International University
name: Huma Riaz, PHD*
role: PRINCIPAL_INVESTIGATOR
References:
citation: Campos GE, Luecke TJ, Wendeln HK, Toma K, Hagerman FC, Murray TF, Ragg KE, Ratamess NA, Kraemer WJ, Staron RS. Muscular adaptations in response to three different resistance-training regimens: specificity of repetition maximum training zones. Eur J Appl Physiol. 2002 Nov;88(1-2):50-60. doi: 10.1007/s00421-002-0681-6. Epub 2002 Aug 15.
citation: Lixandrao ME, Ugrinowitsch C, Laurentino G, Libardi CA, Aihara AY, Cardoso FN, Tricoli V, Roschel H. Effects of exercise intensity and occlusion pressure after 12 weeks of resistance training with blood-flow restriction. Eur J Appl Physiol. 2015 Dec;115(12):2471-80. doi: 10.1007/s00421-015-3253-2. Epub 2015 Sep 1.
citation: Mattar MA, Gualano B, Perandini LA, Shinjo SK, Lima FR, Sa-Pinto AL, Roschel H. Safety and possible effects of low-intensity resistance training associated with partial blood flow restriction in polymyositis and dermatomyositis. Arthritis Res Ther. 2014 Oct 25;16(5):473. doi: 10.1186/s13075-014-0473-5.
citation: Wilson JM, Lowery RP, Joy JM, Loenneke JP, Naimo MA. Practical blood flow restriction training increases acute determinants of hypertrophy without increasing indices of muscle damage. J Strength Cond Res. 2013 Nov;27(11):3068-75. doi: 10.1519/JSC.0b013e31828a1ffa.
citation: Loenneke JP, Allen KM, Mouser JG, Thiebaud RS, Kim D, Abe T, Bemben MG. Blood flow restriction in the upper and lower limbs is predicted by limb circumference and systolic blood pressure. Eur J Appl Physiol. 2015 Feb;115(2):397-405. doi: 10.1007/s00421-014-3030-7. Epub 2014 Oct 22.