louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03654183: Predictive Value of Intraoperative Indocyanine Green Clearance Test After Partially Blood Flow Blocking in Postoperative Liver Reserve
Official title: Predictive Value of Intraoperative Indocyanine Green Clearance Test After Partially Blood Flow Blocking in Postoperative Liver Reserve: a Prospective Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Predictive Value of ICG Clearance Measurement During Selective Hepatic Vascular Trial Clamping on Remnant Liver Function After Anatomic Liver Resection
Lead sponsor: Fudan University
Sponsor class: OTHER
First posted: 2018-08-31
Enrollment: 170
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: (a) patients scheduled to undergo major anatomic liver resection according to clinical assessment, (b) patients'expectation of life longer than 3 months, and (c) age between 18 to 80 years old.

Brief summary: Predictive value of intraoperative indocyanine green clearance measurement during selective hepatic vascular trial clamping on remnant liver function after anatomic liver resection.

Detailed description: In this study, we will prospectively and consecutively enroll patients undergoing hemi-hepatectomy or lateral segmentectomy. ICG clearance measurements will be performed both preoperatively and intraoperatively under partial blood blocking of resecting segments. This study will use PHLF, C-D grade, MELD grade and postoperative hospital stay to evaluate and compare the potential of these measurements to predict postoperative liver function. Accordingly, we are supposed to demonstrate the sensitivity and specificity of intraoperative ICG clearance measurement in detecting postoperative liver failure. Furthermore, cut-off values would be defined to identify high, medium or low risk patients.

Eligibility criteria: Inclusion Criteria:

* (a) patients scheduled to undergo major anatomic liver resection according to clinical assessment, (b) patients'expectation of life longer than 3 months, and (c) age between 18 to 80 years old.

Exclusion Criteria:

* (a) patients could not tolerate liver surgery according to preoperative tests, (b) with no need for major liver resection according to intraoperative assessment, (c) had any contraindications to liver surgery, or (d) ICG metabolic disorder.

Primary outcomes:
measure: PHLF
timeFrame: 5 days after surgery
measure: MELD score
timeFrame: 5 days after surgery
measure: Clavien-Dindo grade
timeFrame: 5 days after surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Fudan University Shanghai Cancer Center
Study officials:
affiliation: Fudan University
name: Lu Wang, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT01119183: Improving Patient Understanding of Preeclampsia
Official title: Improving Patient Understanding of Preeclampsia
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Preeclampsia
Keywords: Patient understanding and counseling
Lead sponsor: Northwestern University
Sponsor class: OTHER
First posted: 2010-05-07
Enrollment: 120
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: Participants counseled with the preeclampsia educational tool will have a better understanding of preeclampsia than those not counseled using the tool.


Eligibility criteria: Inclusion Criteria:

* 12-40 weeks pregnant
* No significant hearing or vision impairment
* English speaking

Exclusion Criteria:

* Active diagnosis of preeclampsia
* Significant hearing or vision impairment
* Non-English speaking

Primary outcomes:
measure: Improved understanding of preeclampsia
timeFrame: one week
Secondary outcomes:
Other outcomes:
Locations:
city: Chicago
country: United States
facility: Northwestern University
state: Illinois
Study officials:
References:
citation: You WB, Wolf MS, Bailey SC, Grobman WA. Improving patient understanding of preeclampsia: a randomized controlled trial. Am J Obstet Gynecol. 2012 May;206(5):431.e1-5. doi: 10.1016/j.ajog.2012.03.006. Epub 2012 Mar 13.
Clinical trial NCT05582083: Managed Access Program for Momelotinib in Myelofibrosis
Official title: Managed Access Program for Momelotinib in Patients With a Diagnosis of Intermediate or High-risk Myelofibrosis (MF), Including Primary Myelofibrosis (PMF) or Secondary Myelofibrosis (Post- Polycythemia Vera/ Essential Thrombocytopenia (PV/ET)), With Anaemia
Study type: EXPANDED_ACCESS
Overall status: NO_LONGER_AVAILABLE
Conditions: Myelofibrosis
Primary Myelofibrosis
Keywords: Momelotinib
GSK3070785
Lead sponsor: GlaxoSmithKline
Sponsor class: INDUSTRY
First posted: 2022-10-17
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT

Brief summary: Compassionate use access to Momelotinib/GSK3070785 for eligible participant with diagnosis of intermediate or high-risk myelofibrosis (MF), including primary myelofibrosis (PMF) or secondary myelofibrosis (post- polycythemia vera/ essential thrombocytopenia (PV/ET)), with anemia.


Eligibility criteria: Inclusion Criteria:

* Written informed consent can be obtained from the patient or legally authorised representative as per local regulations
* Diagnosis of intermediate or high-risk myelofibrosis (MF), including primary myelofibrosis (PMF) or secondary myelofibrosis (post- polycythemia vera/ essential thrombocytopenia (PV/ET)), with anemia
* 18 years or older (at the time consent is obtained)
* The patient is willing to abide by the contraception requirements.
* No known hypersensitivity to momelotinib, its metabolites, or any of the formulation excipients

Exclusion Criteria:

* Pregnant or breastfeeding female

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: GlaxoSmithKline
name: GSK Clinical Trials
role: STUDY_DIRECTOR
References:
Clinical trial NCT06424483: Love Group for Geriatric Psychiatry Outpatients
Official title: Awareness, Courage, and Love Group Psychotherapy for Geriatric Psychiatry Outpatients
Study type: INTERVENTIONAL
Overall status: ENROLLING_BY_INVITATION
Phase: NA
Conditions: Loneliness
Keywords: seniors
mental health
Lead sponsor: London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Sponsor class: OTHER
First posted: 2024-05-22
Enrollment: 50
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomized waitlist control group
Primary purpose: TREATMENT

Brief summary: Loneliness is a key predictor of mortality in older adults, and is a prominent risk factor for mental and physical illness in older adulthood. The goal of this study is to determine the feasibility and acceptability of a group loneliness intervention in geriatric psychiatry outpatients. This type of group loneliness intervention is based on functional analytic psychotherapy (FAP), called Awareness, Courage, and Love (ACL) Groups. The objective of this clinical trial is to adapt, implement, and evaluate the ACL group for outpatients.

Detailed description: The objective of this clinical trial is to adapt, implement, and evaluate a type of loneliness group intervention called Awareness, Courage, and Love Groups for older adult outpatients diagnosed with a psychiatric disorder. The following research questions will be answered: (a) Are ACL groups with geriatric psychiatry outpatients feasible and acceptable? (b) Do such ACL groups demonstrate preliminary efficacy?

Eligibility criteria: Inclusion Criteria:

* Older adults with psychiatric disorder(s)

Exclusion Criteria:

* Individuals who are disoriented to person, delirious, unable to tolerate or participate meaningfully in the group, or otherwise unable to provide consent to research and psychotherapy
* Unable to speak English

Primary outcomes:
measure: De Jong Gierveld Loneliness Scale
timeFrame: Up to 2 months
measure: Attendance and attrition (defined as the number of participants that withdraw (numerator)/number of participants randomised (denominator))
timeFrame: Up to 2 months
measure: Quantitative Program Satisfaction
timeFrame: Up to 2 months
measure: UCLA Loneliness Scale (Neto)
timeFrame: Up to 2 months
Secondary outcomes:
measure: Cantril Self-Anchoring Striving Scale
timeFrame: Up to 2 months
measure: Adaptation of Inclusion of Other in Self Scale
timeFrame: Up to 2 months
measure: Relational Health Indices
timeFrame: Up to 2 months
measure: Sacred Moment Qualities
timeFrame: Up to 2 months
Other outcomes:
measure: Satisfaction Questionnaire
timeFrame: Up to 2 months
Locations:
city: London
country: Canada
facility: St. Joseph's Health Care London
state: Ontario
Study officials:
References:
Clinical trial NCT02909283: Sickle Cell Anemia and Cerebral Microcirculation : Multimodal Exploration
Official title: Determinants of Cerebral Oxygenation and Perfusion in SCA Children Based on Combined ASL MRI, NIRS and Hemorheological Investigation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Sickle Cell Disease
Lead sponsor: Imagine Institute
Sponsor class: OTHER
Collaborators: name: Hopital Universitaire Robert-Debre
First posted: 2016-09-21
Enrollment: 64
Sex: ALL
Minimum age (years): 6
Maximum age (years): 16
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patient included will be patients suffering from Sickle Cell Anemia, and coming at the study center in the frame of their annual follow-up visit.

Brief summary: The aim of this study is to evaluate determinants of cerebral oxygenation and perfusion at the microcirculatory level in children with sickle cell anemia (SCA) using combined novel investigational tools: Arterial Spin Labeling (ASL) perfusion MR (Magnetic Resonnance) imaging, brain Near Infra-Red Spectroscopy (NIRS) and red blood cell (RBC) rheological properties.

Detailed description: The investigators hypothesize that brain perfusion and/or oxygenation modifications may be evidenced in SCA children who have no microarteriopathy and may correlate with hemorheological abnormalities and impaired vasomotion. A multimodal approach designed to study a. cerebral perfusion and oxygenation, b. flow motion properties and c. blood rheological parameters might help to describe the different processes involved in cerebral ischemia.

Eligibility criteria: Inclusion Criteria:

* SS or S-beta° genotype;
* age 6-16 years;
* steady state;
* normal TCD (Transcranial Doppler);
* parental study approval and written informed consent.

Exclusion Criteria:

* SC, Sbeta+, SD Punjab genotype
* history of overt stroke,
* intracranial or cervical arterial stenosis,
* abnormal TCD at the time of the study.

Primary outcomes:
measure: Number of patients on which we detect default of cerebral perfusion (in order to correlate them with other clinical or biological parameters)
timeFrame: 1.5 years
Secondary outcomes:
measure: Bifrontal cerebral hemoglobin oxygen saturation
timeFrame: 1.5 years
measure: Description of the global assessment of RBC deformability
timeFrame: 1.5 years
Other outcomes:
Locations:
city: Créteil
country: France
facility: Centre Hospitalier Intercommunal
city: Paris
country: France
facility: Necker - Enfants Malades hospital
Study officials:
affiliation: Hôpital Necker-Enfants Malades
name: Valentine Boursse
role: PRINCIPAL_INVESTIGATOR
affiliation: Centre Hospitalier intercommunal de Créteil
name: Suzanne Verlhac
role: STUDY_DIRECTOR
References:
Clinical trial NCT02641483: Stimulation for Colonic Motility
Official title: Afferent Stimulation to Evoke Recto-colonic Reflex for Colonic Motility
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Neurogenic Bowel Dysfunction
Lead sponsor: VA Office of Research and Development
Sponsor class: FED
First posted: 2015-12-29
Enrollment: 2
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The investigators are testing the effect of electrical stimulation of the rectum on colonic motility. Most individuals with spinal cord injury develop neurogenic bowel dysfunction, which includes slowed colonic motility, which means that stools take longer than normal to pass through the colon. This slowed movement may result in chronic constipation and difficulty emptying the bowels. Individuals typically (without or without caregiver assistance) insert a gloved finger into the rectum and gently stretch it to improve colonic motility for a brief period to empty the bowels. The investigators hypothesize that electrically stimulating the rectum, instead of mechanically stretching it, will produce the same beneficial effect of improving colonic motility. Therefore, this study will compare the two methods. If electrical stimulation effectively improves colonic motility, then the investigator shall develop the approach as a therapeutic intervention in future studies.


Eligibility criteria: Inclusion Criteria:

* Diagnosed neurogenic bowel dysfunction and using digital rectal stimulation
* Neurologically stable
* Skeletally mature
* Suprasacral spinal cord injury, stroke, or multiple sclerosis
* At least 6 months post neurological injury or disease diagnosis

Exclusion Criteria:

* Active sepsis
* Open pressure sores on or around pelvis
* Significant colon trauma or colostomy
* History of autonomic dysreflexia

Primary outcomes:
measure: Compare Changes in Number of Interventions Used to Complete Bowel Routine, Including Electrical Rectal Stimulation (Treatment) Versus Mechanical Rectal Distension (Control)
timeFrame: 1 month
Secondary outcomes:
Other outcomes:
Locations:
city: Syracuse
country: United States
facility: Syracuse VA Medical Center, Syracuse, NY
state: New York
city: Cleveland
country: United States
facility: Louis Stokes VA Medical Center, Cleveland, OH
state: Ohio
Study officials:
affiliation: Louis Stokes VA Medical Center, Cleveland, OH
name: Dennis Bourbeau, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00982683: Association of Lunar Phases With Post-surgical Morbidity
Official title: Association of Lunar Phases With Post-surgical Hemorrhagic Rate
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hemorrhage
Keywords: Surgery
Moon phases
hemorrhage
Lead sponsor: IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
Sponsor class: OTHER
Collaborators: name: University of Genova
First posted: 2009-09-23
Enrollment: 26244
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients operated at the National Cancer Institute, Genoa, Italy, during the period 2001-2008

Brief summary: The potential influence of lunar phases on human life has been widely discussed by the lay press. The purpose of this study was to evaluate a possible relation between the lunar cycle and the hemorrhagic complication rate and surgical outcome.

PATIENTS AND METHODS:

The investigators tested this hypothesis by evaluating the complication rate for 18760 patients who underwent surgery from January 2001 to December 2008 (103 lunar phases) at the National Institute for Cancer Research in Genoa.

The date of definitive surgery was allocated to the lunar phases.


Eligibility criteria: Inclusion Criteria:

* None

Exclusion Criteria:

* None

Primary outcomes:
measure: Dependence analysis between post-surgical complications and lunar phases.
timeFrame: 2001 - 2008
Secondary outcomes:
Other outcomes:
Locations:
city: Genova
country: Italy
facility: National Cancer Institute, Italy
Study officials:
affiliation: National Cancer Institute, Italy
name: Edoardo Raposio, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Sha LR, Xu NT, Song XH, Zhang LP, Zhang Y. Lunar phases, myocardial infarction and hemorrheological character. A Western medical study combined with appraisal of the related traditional Chinese medical theory. Chin Med J (Engl). 1989 Sep;102(9):722-5.
Clinical trial NCT01388283: Inflammatory Markers in Pregnant Women Destined to Develop Preeclampsia
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Preeclampsia
Keywords: prognostic marker
Lead sponsor: Oslo University Hospital
Sponsor class: OTHER
First posted: 2011-07-06
Enrollment: 129
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 43
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Case-control study consisting of 43 women developping preeclampsia and 86 women not developping this disorder. All were of Caucasian origin and were nulliparous.

Brief summary: The purpose of this study is to assess the predictive role of serum inflammatory markers in pregnant women who subsequently develop preeclampsia.


Eligibility criteria: Inclusion Criteria:

* caucasian,
* nulliparous

Exclusion Criteria:

* preexisting cardiovascular diseases,
* diabetes,
* hypertension,
* inflammatory bowel diseases,
* serious organ diseases, and
* development of separate gestational diabetes and/or hypertension.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03413683: Frailty in Older HIV-infected Individuals
Official title: Frailty in Older HIV-infected Individuals in Hong Kong: Risk Factors and Association With Quality of Life and Mortality
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: HIV Infections
Lead sponsor: Chinese University of Hong Kong
Sponsor class: OTHER
First posted: 2018-01-29
Enrollment: 100
Sex: ALL
Minimum age (years): 50
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: HIV-positive patients who attend Infectious Diseases clinic at Prince of Wales Hospital

Brief summary: Frailty has been proposed as a measure of biological (as opposed to chronological) aging. In this study the investigators plan to: (1) measure frailty in a cohort of older HIV-infected individuals in Hong Kong, and its association with mortality and quality of life; (2) identify risk factors predictive of development of frailty in HIV-infected individuals in Hong Kong; and (3) determine the outcomes of HIV-infected individuals in Hong Kong with and without frailty.

The following assessment will be done:

1. Physical examination including measuring height, weight, hip and waist circumference.
2. Grip strength, chair stand test, gait speed test, balance tests, and neurocognitive tests
3. Geriatric syndromes, screening for depression, disability and quality of life.
4. Blood tests during fasting state to measure metabolic parameters.

This is a prospective longitudinal observational study that lasts for 10 years.


Eligibility criteria: Inclusion Criteria:

* HIV infection with positive anti-HIV antibody
* Age ≥50 years

Exclusion Criteria:

* Refuses to consent

Primary outcomes:
measure: Frailty
timeFrame: 10 years
Secondary outcomes:
Other outcomes:
Locations:
city: Sha Tin
country: Hong Kong
facility: Prince of Wales Hospital
Study officials:
affiliation: CUHK
name: Grace Lui
role: PRINCIPAL_INVESTIGATOR
References:
citation: Fried LP, Tangen CM, Walston J, Newman AB, Hirsch C, Gottdiener J, Seeman T, Tracy R, Kop WJ, Burke G, McBurnie MA; Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: evidence for a phenotype. J Gerontol A Biol Sci Med Sci. 2001 Mar;56(3):M146-56. doi: 10.1093/gerona/56.3.m146.
Clinical trial NCT06536283: Opiophobia in Postsurgical Adults With Cancer
Official title: Opiophobia in Postsurgical Adults With Cancer
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Opiophobia
Lead sponsor: M.D. Anderson Cancer Center
Sponsor class: OTHER
Collaborators: name: Sigma Theta Tau International
First posted: 2024-08-02
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: MD Anderson Cancer Center

Brief summary: To learn how people who underwent surgery feel about their prescribed opioid medication after they leave the hospital.

Detailed description: To explore the barriers and fears related to use of opioids among a population of adults who underwent surgery for cancer who were prescribed opioids for home use during the first week following hospital discharge for a surgical treatment of a malignancy.

Eligibility criteria: Inclusion Criteria:

1. Adult patient with cancer admitted for cancer-related surgery
2. inpatient surgical hospital stay lasting at least 23 hours
3. discharged home with a prescription for opioid analgesics
4. able to read, speak, and consent in English.

Exclusion Criteria:

1. Age less than 18 years
2. not discharged with a prescription for opioid analgesia to manage pain
3. individuals for whom there is documentation of inability to provide consent in the medical record.

Primary outcomes:
measure: To explore the barriers and fears related to use of opioids among a population of adults who underwent surgery for cancer.
timeFrame: Through study completion, an average of 1 year.
Secondary outcomes:
Other outcomes:
Locations:
city: Houston
country: United States
facility: The Univerisity of Texas M. D. Anderson Cancer Center
state: Texas
Study officials:
affiliation: M.D. Anderson Cancer Center
name: Eileen Hacker, PHD,RN
role: PRINCIPAL_INVESTIGATOR
References: