Clinical trial NCT05710549: Understanding Brain Mechanisms Involved in Autobiographical Memory
Official title: Understanding Brain Mechanisms Involved in Autobiographical Memory Using High-density Electroencephalography and Transcranial Alternating Current Stimulation
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Mild Cognitive Impairment
Alzheimer Disease
Memory Loss
Keywords: autobiographical memory (ABM)
high-density electroencephalography (EEG)
magnetic resonance imaging (MRI)
non-invasive brain stimulation (NIBS)
transcranial alternating current stimulation (tACS)
Lead sponsor: University of Geneva, Switzerland
Sponsor class: OTHER
First posted: 2023-02-02
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The overall objective of this project is to characterize the spatiotemporal dynamics of brain oscillations underpinning autobiographical memory (ABM) and the modulation of the memory network using non-invasive brain stimulation.

Detailed description: Accumulating evidence suggests that activity in distributed networks supporting ABM is altered even decades before the expected onset of clinical symptoms in Alzheimer's disease (AD). Robust network alterations associated with age-related memory and cognitive decline have been linked to abnormal oscillatory brain rhythmic activity and functional dysconnectivity. However, the detailed neural mechanisms are still poorly understood. The investigators propose to precisely characterize the underlying neurophysiological mechanisms that lead to behavioral and cognitive disturbances in ABM of MCI patients. Specifically, hdEEG will be used to characterize the sources and spatiotemporal dynamics of the neuronal activity involved in the ABM network of 40 mild cognitive impairment (MCI) patients and compare it to 40 age-matched, older healthy participants and 40 healthy young participants. The investigators will then apply non-invasive brain stimulation in the form of transcranial alternating current stimulation (tACS) to gain novel insights into the causal role of brain oscillations in the ABM network of MCI patients.

Eligibility criteria: Inclusion Criteria:

Cognitively-Unimpaired Younger and Older Adults

* Age 18 to 35 years old (younger adults)
* Age 55+ years old (older adults)
* without any cognitive impairment (based on the Montreal Cognitive Assessment: MoCA)
* willing and capable to give informed consent for participation in the study after it has been thoroughly explained able
* willing to comply with all study requirements informed consent form was signed

Mild Cognitive Impairment (MCI) patients

* Age 55+ years old
* Clinical Diagnosis of MCI
* Confirmation of diagnosis will be made by the study MD based on a holistic consideration of the participant's cognitive evaluation and history
* Mini-Mental State Examination (MMSE) ≥ 18 (Mild AD ≥ 21)
* CDR ≥ .5
* Demonstration or history of autobiographical memory impairments
* On a stable dose of medications for memory loss including cholinesterase inhibitors (e.g. donepezil, rivastigmine) or memantine as defined as 6 consecutive weeks of treatment at an unchanging dose
* Minimum of completed 8th-grade education
* willing and capable to give informed consent for participation in the study after it has been thoroughly explained - note that to ensure this in the case of the MCI participants, a cut-off of MOCA score \>18 will be applied
* able and willing to comply with all study requirements informed consent form was signed

Exclusion Criteria:

Cognitively-Unimpaired Younger and Older Adults

* any cognitive impairment captured by the Montreal Cognitive Assessment (MoCA) - score \< 26
* major psychiatric co-morbidity including major depressive disorder, schizophrenia, or psychosis
* blindness or other disabilities that prevent task performance
* Contraindication for undergoing MRI
* Any metal in the brain or skull (excluding dental fillings) or elsewhere in the body unless cleared by the responsible covering MD (e.g. MRI compatible joint replacement)

Mild Cognitive Impairment (MCI) patients

* Age \< 55 years old
* Any current diagnosis of a major psychiatric disorder (e.g., schizophrenia, bipolar disorder, major depressive disorder)
* Other than MCI, any history of other progressive or genetic neurologic disorder (e.g. Parkinson's disease, multiple sclerosis, tubular sclerosis) or acquired neurological disease (e.g. stroke, traumatic brain injury, tumor), including intracranial lesions
* History of head trauma resulting in prolonged loss of consciousness
* Current history of poorly controlled headaches including chronic medication for migraine prevention
* History of fainting spells of unknown or undetermined etiology that might constitute seizures
* History of seizures, diagnosis of epilepsy, or immediate (1st-degree relative) family history of epilepsy with the exception of a single seizure of benign etiology (e.g. febrile seizures) in the judgment of a board-certified neurologist
* Any unstable medical condition or chronic (particularly) uncontrolled medical conditions that may cause a medical emergency in case of a provoked seizure (cardiac malformation, cardiac dysrhythmia, asthma, etc.) or study complication
* contraindications to tACS, as recorded on a standardized screening questionnaire, which include a reported seizure within the past two years, use of neuroactive drugs, self-reported presence of specific implanted medical devices (e.g., deep brain stimulator, medication infusion pump, cochlear implant, pacemaker, etc.), or the presence of any active dermatological condition, such as eczema, on the scalp
* Contraindication for undergoing MRI or receiving tACS
* Any metal in the brain or skull (excluding dental fillings) or elsewhere in the body unless cleared by the responsible covering MD (e.g. MRI compatible joint replacement)
* Any devices such as a pacemaker, medication pump, nerve stimulator, TENS unit, ventriculoperitoneal shunt unless cleared by the responsible covering MD

Primary outcomes:
measure: Spatiotemporal dynamic changes measured with electroencephalography (hdEEG)
timeFrame: up to 30 minutes
measure: Cognitive Assessment
timeFrame: baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Geneva
country: Switzerland
facility: University of Geneva, Campus Biotech
Study officials:
affiliation: University of Geneva (UNIGE)
name: Christoph Michel, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Geneva University Hospitals (HUG)
name: Giovanni Frisoni, PhD
role: STUDY_CHAIR
References:
citation: Brechet L, Brunet D, Birot G, Gruetter R, Michel CM, Jorge J. Capturing the spatiotemporal dynamics of self-generated, task-initiated thoughts with EEG and fMRI. Neuroimage. 2019 Jul 1;194:82-92. doi: 10.1016/j.neuroimage.2019.03.029. Epub 2019 Mar 19.
citation: Roehri N, Brechet L, Seeber M, Pascual-Leone A, Michel CM. Phase-Amplitude Coupling and Phase Synchronization Between Medial Temporal, Frontal and Posterior Brain Regions Support Episodic Autobiographical Memory Recall. Brain Topogr. 2022 Mar;35(2):191-206. doi: 10.1007/s10548-022-00890-4. Epub 2022 Jan 26.
citation: Michel CM, He B. EEG source localization. Handb Clin Neurol. 2019;160:85-101. doi: 10.1016/B978-0-444-64032-1.00006-0.