louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00522977: Echo-Cardiographic Assessment of Cardiovascular Characteristics During Pregnancy and Postpartum Periods
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Pregnancy
Keywords: Myocardial strain
Myocardial function
Pregnancy
Postpartum
Echocardiography
Myocardial adaptation to pregnancy
Systolic function
Diastolic function
Lead sponsor: Hillel Yaffe Medical Center
Sponsor class: OTHER_GOV
First posted: 2007-08-30
Enrollment: 400
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Healthy women in first trimester of pregnancy.

Brief summary: The purpose of this echocardiographic study is to restudy the longitudinal changes in cardiac size and function during and after pregnancy in healthy women using relatively new parameters of systolic and diastolic function as well as classical measures of left ventricle (LV) function using contemporary echocardiographic machines.

We, the researchers at Hillel Yaffe Medical Center, will assess diastolic function and its possible relation to shortness of breath.

Detailed description: A comprehensive echocardiographic study of the heart will be conducted in the first, second and third trimesters of pregnancy and 3 months postpartum.

Determination of left ventricular dimensions, transvalvular Doppler flow, ejection fraction, stroke volume, cardiac output, pulmonary vein flow, tissue Doppler, flow propagation, global and segmental strain parameters, timing of peak strain and various parameters of diastolic function will be obtained.

From these data normal values for various stages of pregnancy will be determined as well as range for changes expected during longitudinal follow-up will be determined.

Eligibility criteria: Inclusion Criteria:

* Healthy women
* First trimester of a normal pregnancy
* Normal baseline echocardiogram

Exclusion Criteria:

* Pregnancy with more than one fetus.
* Any hemodynamically significant cardiac condition
* Any known systemic disease
* Poor quality echocardiogram

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Hadera
country: Israel
facility: Hille Yaffe Medical Center
Study officials:
affiliation: Hillel Yaffe Medical Center
name: David S Blondheim, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Hillel Yaffe Medical Center
name: Asnat Walfisch, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Hillel Yaffe Medical Center
name: Mordechai Hallak, Prof.
role: STUDY_CHAIR
affiliation: Hillel Yaffe Medical Center
name: Avraham Shotan, MD
role: STUDY_DIRECTOR
affiliation: Hillel Yaffe Medical Center
name: Kazatzker Mark, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01018277: Effect of Mobilization on Acute Postoperative Pain and Nociceptive Function
Official title: Effect of Mobilization on Acute Postoperative Pain and Nociceptive Function After Total Knee Arthroplasty: A Prospective, Consecutive, Trial
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pain, Postoperative
Pain Sensitivity, Postoperative
Lead sponsor: Hvidovre University Hospital
Sponsor class: OTHER
Collaborators: name: Lundbeck Foundation
First posted: 2009-11-23
Enrollment: 26
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients operated with TKA

Brief summary: Aim of the present study is twofold.

* First we want to evaluate the effect of mobilization on acute postoperative pain
* Second to test weather chances in pain sensitivity are occurring following surgery and mobilization after total knee arthroplasty

Detailed description: Little is known about the effect of mobilization on acute postoperative pain and mobilization induced pain, and if altered pain sensitivity occur under these circumstances.

* First we want to evaluate the effect of mobilization on acute postoperative pain using the visual analog scale (VAS)
* Second to test weather chances in pain sensitivity are occurring following surgery and mobilization after total knee arthroplasty, using two simple tools, the Pain Matcher and a Pressure Algometer.

Eligibility criteria: Inclusion Criteria:

* Patients scheduled for total unilateral knee arthroplasty

Exclusion Criteria:

* Cognitive dysfunction or peripheral / central neurological dysfunction inconsistent with protocol completing
* Alcohol and medical abuse (as defined by the National Health Service of Denmark
* Daily use of opioids or glucocorticoids

Primary outcomes:
measure: Pain score on the visual analog scale (difference before and after two mobilisation seances)
timeFrame: up to 24 hours
Secondary outcomes:
measure: Pain score on the visual analog scale (difference before and after two mobilisation seances)
timeFrame: up to 24 hours
measure: Pain sensitivity measured with pressure algometry and with pain matcher (difference before and after two mobilisation seances and difference before and after surgery)
timeFrame: up to 24 hours
Other outcomes:
Locations:
city: Copenhagen
country: Denmark
facility: Hvidovre University Hospital
state: Hvidovre
Study officials:
affiliation: Hvidovre University Hospital
name: Troels Haxholdt Lunn, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02374177: The Effects of Anaesthetic Agents on Postoperative Delirium
Official title: The Effects of Anaesthetic Agents on Postoperative Delirium in the Patients Undergoing Off-pump Coronary Artery Bypass Grafting Surgery
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Delirium
Lead sponsor: Konkuk University Medical Center
Sponsor class: OTHER
First posted: 2015-02-27
Enrollment: 292
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The medical records of the patients undergoing off-pump CABG in Konkuk University Medical Centre from Jan 2010 to Aug 2014 were retrospectively reviewed.

Brief summary: The purpose of this study is to prove the correlation between the post-operative delirium (POD) and anesthetic agents. The investigators hypothesized that intravenous anaesthetics would show the lower incidence of POD, compared with inhalation anaesthetics in off-pump CABG.

Detailed description: The medical records of the patients undergoing off-pump coronary artery bypass grafting (CABG) in Konkuk University Medical Centre from Jan 2010 to Aug 2014 were retrospectively reviewed.

Eligibility criteria: Inclusion Criteria:

* Patients undergoing off-pump coronary artery bypass grafting

Exclusion Criteria:

* Other concurrent surgery
* Conversion from off-pump coronary artery bypass grafting to on-pump coronary artery bypass grafting

Primary outcomes:
measure: Incidence of postoperative delirium
timeFrame: up to postoperative 7 days
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Konkuk University Medical Center
name: Seong-Hyop Kim, Professor
role: PRINCIPAL_INVESTIGATOR
References:
citation: Koster S, Hensens AG, van der Palen J. The long-term cognitive and functional outcomes of postoperative delirium after cardiac surgery. Ann Thorac Surg. 2009 May;87(5):1469-74. doi: 10.1016/j.athoracsur.2009.02.080.
Clinical trial NCT04112277: Observational Prospective Study of Opiate-free Anesthesia for Anterior Total Hip Replacement
Official title: Observational Prospective Study of Opiate-free Anesthesia for Anterior Total Hip Replacement
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Rehabilitation
Analgesia
Anesthesia
Lead sponsor: Hôpital Privé Sévigné
Sponsor class: OTHER
First posted: 2019-10-02
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with ASA (American Society of Anesthesiology) I-III for whom a total Hip Prosthesis is programmed anteriorly (Hueler Method).

Brief summary: Opioid-free anesthesia (ATO) is a multimodal anaesthesia combining different analgesic and anesthetic modalities thus excluding opiates as an intraoperative. Recent studies have found a benefit from the ATO on postoperative rehabilitation and reduced length of hospitalization.

Periarticular infiltration with a local anesthetic is one of the measures proposed in OFA during the PTH.

PTH remains a painful procedure and the occurrence of morphinic-related side effects in sometimes elderly patients is often observed.

The main objective of this study is to assess the feasibility of ATO in anterior hip replacement under general anesthesia with the primary endpoint of morphine consumption measured 24 hours after surgery.


Eligibility criteria: Inclusion Criteria:

* Age 18 and 85
* ASA (American Society of Anesthesiology) I-III
* Total Hip Prosthesis programmed anteriorly
* Prior obtaining free and informed written consent .Affiliation or beneficiary of a social security scheme. Patients affiliated with or beneficiaries of a social security plan and not included in another trial.

Exclusion Criteria:

* Pregnant women or breastfeeding Spinal anesthesia Patient on long-term opiate Body Mass Index (BMI) - 20 or 45kg/m2 Incomprehension of the ENS scale Unaccompanied cardiac conduction disorder, Adam-Stokes syndrome Preoperative Spontaneous Cardiac Frequency - 40 beats/min Left ventricle ejection fraction - 40% Unpaired sleep apnea syndrome (OSA) Adult incompetent, adults under guardianship or curatorial or deprived of liberty Allergy to one of the protocol products or their excipients: levobupivacaine, paracetamol, pregabalin, ketoprofen, dexmedetomidine Paracetamol-specific contraindication: hepatocellular deficiency Ketoprofen-specific contraindications: creatinine clearance - 60ml/min, ATCD of perforated peptic ulcer, heart failure, progressive hemorrhage, asthma associated with ketoprofen use Contraindications to nefopam: symptomatic prostate disorders, angle-closing glaucoma, epilepsy Participation in another clinical study

Primary outcomes:
measure: Cumulative morphine consumption
timeFrame: 24 hours after the procedure
Secondary outcomes:
Other outcomes:
Locations:
city: Cesson-Sévigné
country: France
facility: Hopital Privé Sévigné
Study officials:
References:
Clinical trial NCT00246077: Quality of Life of Children With Sickle Cell Disease Who Are Getting Chronic Transfusions With a Lifeport
Official title: Quality of Life of Children With Sickle Cell Disease Who Are Receiving Chronic Transfusion Therapy With a Lifeport Device
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Anemia, Sickle Cell
Keywords: chronic transfusion therapy
quality of life
Lead sponsor: Children's Mercy Hospital Kansas City
Sponsor class: OTHER
First posted: 2005-10-30
Enrollment: 5
Sex: ALL
Minimum age (years): 8
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Time perspective: OTHER

Brief summary: This study is being done to see what impact having a Lifeport device has on quality of life for children with sickle cell who are getting chronic transfusions, from the child's perspective.

Detailed description: There is a paucity of research that focuses specifically on quality of life (QoL) among patients with sickle cell. This study aims to explore the QoL of children who are receiving chronic transfusion therapy (CTT) using a Lifeport device, which allows them to undergo erythrocytapheresis, rather than standard transfusion therapy. Erythrocytapheresis is less time consuming and is associated with less iron overload than conventional transfusion therapy; however, little is known about the implications for the child's QoL. This study will explore QoL from the child's perspective.

Eligibility criteria: Inclusion Criteria:

* Individuals with a diagnosis of sickle cell disease between the ages of 8 \& 18 years
* currently receiving chronic transfusion therapy via a Lifeport device
* Individuals have been utilizing the Lifeport for at least 6 months and no more than 18 months
* Individuals have received transfusions previously using conventional transfusion therapy (simple or exchange transfusions)
* Individuals have permission of parents (when applicable) and assent

Exclusion Criteria:

* Individuals who, in the opinion of the study staff, would suffer negative consequence, psychosocial trauma, or undue stress as a result of participation

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Kansas City
country: United States
facility: The Children's Mercy Hospital
state: Missouri
Study officials:
affiliation: Children's Mercy Hospital Kansas City
name: Susan Sarcone, RN
role: STUDY_DIRECTOR
References:
Clinical trial NCT06367777: Cervical/Thoracic Neuromodulation and Nociceptive Processing
Official title: Investigating the Effects of the Neuromodulation of the Cervical and the Low-thoracic Spinal Cord on Nociceptive Processing in Healthy Volunteers - an Randomized, Sham-controlled, Double-blinded Study
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Nociceptive Pain
Keywords: tsDCS
non-invasive neuromodulation
healthy volunteers
Lead sponsor: Université Catholique de Louvain
Sponsor class: OTHER
First posted: 2024-04-16
Enrollment: 24
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: Several studies have demonstrated that direct currents delivered through the skin at the level of the low-thoracic spinal cord can influence spinal cord function. In human volunteers, anodal low-thoracic transcutaneous spinal direct current stimulation (tsDCS) alters spinal processing of nociceptive inputs. Whether cervical tsDCS is able to do the same is less well known. In this double-blinded, sham-controlled and cross-over trial, the investigators will compare the effects on the nociceptive processing of healthy volunteers of cervical and low-thoracic tsDCS.

Detailed description: The investigators will compare the effects on the nociceptive processing of healthy volunteers of cervical and low-thoracic tsDCS. This study will be a double-blinded, sham-controlled, cross-over trial. Each participant will undergo three experimental sessions (anodal cervical tsDCS and sham thoracic tsDCS vs. sham cervical tsDCS and anodal thoracic tsDCS vs. sham cervical tsDCS and sham thoracic tsDCS), separated by at least one week.

Eligibility criteria: Inclusion Criteria:

Healthy young adults

Exclusion Criteria:

* Known medical conditions (e.g., diabetes, neuropathy, psychiatric disorders, seizure, migraine, pacemaker or other implanted medical devices...)
* Use of any medication (except contraception)

Primary outcomes:
measure: Change in contact-heat evoked potentials amplitude
timeFrame: Throughout the entire study, approximately during 6 months
Secondary outcomes:
measure: Change in intensity of perception to contact-heat nociceptive stimuli
timeFrame: Throughout the entire study, approximately during 6 months
measure: Change in skin temperature
timeFrame: Throughout the entire study, approximately during 6 months
measure: Change in cutaneous blood flow
timeFrame: Throughout the entire study, approximately during 6 months
Other outcomes:
Locations:
city: Brussels
country: Belgium
facility: UCLouvain
Study officials:
affiliation: Université Catholique de Louvain
name: André Mouraux, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Lenoir C, Jankovski A, Mouraux A. Anodal Transcutaneous Spinal Direct Current Stimulation (tsDCS) Selectively Inhibits the Synaptic Efficacy of Nociceptive Transmission at Spinal Cord Level. Neuroscience. 2018 Nov 21;393:150-163. doi: 10.1016/j.neuroscience.2018.10.007. Epub 2018 Oct 12.
Clinical trial NCT04523077: Association of Oral Lichen Planus and Thyroid Disease
Official title: Association of Oral Lichen Planus and Thyroid Disease
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Oral Lichen Planus
Thyroid Diseases
Keywords: oral lichen planus
thyroid diseases
Lead sponsor: University of Zagreb
Sponsor class: OTHER
First posted: 2020-08-21
Enrollment: 50
Sex: FEMALE
Minimum age (years): 35
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The study included female patients of the Department of Oral Medicine, age matched, with oral lichen planus and without oral lichen planus or other immune disorders. All patients included in the study made blood test and the results were analyzed with statistical methods.

Brief summary: Thyroid disease is a common endocrine disorder. Oral lichen planus (OLP) is a chronic autoimmune disease that occurs on the oral mucosa in 1-2% of the general population.The purpose of this study was to determine whether there is an association between thyroid disease and oral planus lichen in the population of our patients. In the last few years, a couple of studies have been published in the world literature that have studied the possible association of these diagnoses in different populations. Most of the results showed a higher prevalence of thyroid disease in the population of lichen patients, compared with patients without lichen, although some results are contradictory. Some authors believe that the onset of OLP precedes thyroid dysfunction. In the population of Croatian patients with lichen, no research has been done to study the possible connection between these two diseases. The obtained results could help clarify whether there is a connection between these two diagnoses in the population of our lichen patients and enable earlier detection of patients with thyroid hypofunction.


Eligibility criteria: Inclusion Criteria:

* for test group: female patients of the Department of Oral Medicine School of Dental Medicine University of Zagreb with clinically and histopathologically confirmed oral lichen planus
* for control group: female patients of the Department of Oral Medicine School of Dental Medicine University of Zagreb, without oral lichen planus or other immune disorders; age matched to test group

Exclusion Criteria:

* male patients; female patients with immune disorders; female patients which are not age-matched to test group

Primary outcomes:
measure: The prevalence of thyroid diseases in patients with oral lichen planus
timeFrame: January 2020-April 2020
Secondary outcomes:
Other outcomes:
Locations:
city: Zagreb
country: Croatia
facility: School of Dental Medicine, University of Zagreb
Study officials:
References:
Clinical trial NCT05618977: The Effect of Dramatization Simulation on Nursing Students' Ethical Attitudes
Official title: The Effect of Dramatization Simulation on Nursing Students' Ethical Attitudes: A Mixed Method Research
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: ETIC
Lead sponsor: Çankırı Karatekin University
Sponsor class: OTHER
First posted: 2022-11-16
Enrollment: 60
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: Nursing students face many ethical problems in their clinical practice. It is very likely that they will encounter ethical problems after graduation. For this reason, students should be given an ethical attitude before graduating. It is very difficult to gain an ethical attitude. Ethical issues, on the other hand, are very difficult to gain as they are a limited concept. Therefore, different methods should be used in teaching. Dramatization simulation is one of the teaching methods used recently. It is especially effective in making abstract concepts that are difficult to understand concrete. It is thought that students participating in a dramatized simulation will be effective in gaining ethical attitudes by recognizing ethical problems more easily. This research will be carried out to determine the effect of dramatization simulation on the ethical attitudes of nursing students.

Detailed description: The effect of dramatization simulation on the ethical attitudes of nursing students will be evaluated.

Eligibility criteria: Inclusion Criteria:

\* Students who agreed to participate in the study

Exclusion Criteria:

* Not participating in dramatization simulation applications,
* Not participating in classroom ethical case studies

Primary outcomes:
measure: Ethical attitude
timeFrame: Four weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Cankiri
country: Turkey
facility: Cankiri Karatekin University
Study officials:
References:
Clinical trial NCT05716477: Blood Test (Guardant Shield™) for Screening of Colorectal Cancer in Underserved Patients
Official title: The Ohio State University Guardant Shield™ Colorectal Cancer Screening Project
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Colorectal Carcinoma
Lead sponsor: Ohio State University Comprehensive Cancer Center
Sponsor class: OTHER
Collaborators: name: Guardant Health, Inc.
First posted: 2023-02-08
Enrollment: 146
Sex: FEMALE
Minimum age (years): 45
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Recruit women age 45 years and older who are in need of colorectal cancer screening from minority and underserved populations via a community mammography van.

Brief summary: This clinical trial evaluates the use of a blood test (Guardant Shield™) for colorectal cancer screening. Colorectal cancer is the third leading cancer and cause of death in the United States. Screening may help doctors find colorectal cancer early when it is easier to treat yet nearly a third of all people eligible for screening have never had a screening test performed. Currently, doctors use a stool- based test such as the fecal immunochemical test (FIT) and visual tests such as a colonoscopy. Blood based testing such as Guardant Shield™, may provide a quick and effective way to screen patients that are hard to reach or with limited access (underserved).

Detailed description: PRIMARY OBJECTIVES:

I. Recruit women age 45 years and older who are in need of colorectal cancer screening from minority and underserved populations via a community mammography van.

II. Obtain data regarding knowledge, attitudes and beliefs about colorectal cancer screening.

OUTLINE:

Participants undergo blood specimen collection and complete survey on study. Participants may optionally undergo standard of care FIT testing on study.

Eligibility criteria: Inclusion Criteria:

* Women aged 45 years of age and older who are in need of colorectal screening
* Do not have a history of cancer
* Able to read and understand English
* Have a provider to receive the results of the test and who will follow-up test results
* Able to provide informed consent

Primary outcomes:
measure: Number of patients consented
timeFrame: Up to 2 years
measure: Percentage of patients consented
timeFrame: Up to 2 years
measure: Knowledge about colorectal screening
timeFrame: Up to 2 years
measure: Attitudes about colorectal screening
timeFrame: Up to 2 years
measure: Beliefs about colorectal screening
timeFrame: Up to 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Columbus
country: United States
facility: Ohio State University Comprehensive Cancer Center
state: Ohio
Study officials:
affiliation: Ohio State University Comprehensive Cancer Center
name: Electra D Paskett, PhD
role: PRINCIPAL_INVESTIGATOR
References: