Clinical trial NCT02673398: Neratinib in Treating Older Patients With Stage IV HER2-Positive Breast Cancer
Official title: Phase II Study of Neratinib in Patients 60 and Older With HER2 Positive Metastatic Breast Cancer
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: HER2 Positive Breast Carcinoma
Stage IV Breast Cancer AJCC v6 and v7
Lead sponsor: City of Hope Medical Center
Sponsor class: OTHER
Collaborators: name: National Cancer Institute (NCI)
First posted: 2016-02-03
Enrollment: 25
Sex: ALL
Minimum age (years): 60
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This phase II trial studies the side effects of and how well neratinib works in treating older patients with stage IV HER2-positive breast cancer. Neratinib may stop the growth of tumor cells by blocking some of the enzymes needed for cell growth.

Detailed description: PRIMARY OBJECTIVES:

I. To estimate the safety and tolerability of neratinib in adults age 60 or older with locally advanced or metastatic HER2 over-expressing breast cancer.

SECONDARY OBJECTIVES:

I. To describe the full toxicity profile including all grade toxicities measured by National Cancer Institute (NCI) Common Terminology Criteria for Adverse Events (CTCAE) version (v)4.0.

II. To estimate the rate of all grades of gastrointestinal (GI) toxicities such as diarrhea, nausea, and vomiting.

III. To estimate the rate of dose reduction, delays and discontinuation related to study drug.

IV. To describe pharmacokinetic parameters of neratinib in adults 60 and older. V. To estimate overall response rate (ORR) and clinical benefit rate (CBR) defined by Response Evaluation Criteria in Solid Tumors (RECIST) 1.1.

VI. To estimate event free survival (EFS), progression-free survival (PFS) and overall survival (OS).

VII. To evaluate the role of cancer-specific geriatric assessment tool in predicting treatment toxicities.

VIII. To estimate adherence rate to neratinib in older adults (percentage of doses of neratinib taken).

IX. To explore the association of pharmacokinetic (PK) parameters and geriatric assessment findings.

X. To explore if serum biomarkers of aging (interleukin \[IL\]-6, C-reactive protein \[CRP\], and D-dimer) are associated with treatment toxicities.

OUTLINE:

Patients receive neratinib orally (PO) once daily (QD) on days 1-28. Cycles repeat every 28 days in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up for 30 days and then periodically thereafter.

Eligibility criteria: Inclusion Criteria:

* Eastern Cooperative Oncology Group (ECOG) performance 0-2
* Life expectancy of greater than 12 weeks
* Histologically or cytologically proven metastatic breast cancer (metastases can be proven with imaging results in certain circumstances provided that the initial tumor was demonstrated histologically)
* Stage IV HER2/Neu positive breast cancer patients who failed previous anti-HER2 targeted therapies
* HER2 positivity as defined by American Society of Clinical Oncology (ASCO)/College of American Pathologists (CAP) guidelines
* If HER2 negative by immunohistochemistry (IHC) or fluorescence in situ hybridization (FISH), but activating somatic mutations of HER2 gene identified through genomic sequencing including but not limited to the following (Clinical Laboratory Improvement Act \[CLIA\] certified lab test): missense substitutions (G309A, G309E, S310F, S310Y, S653C, V659E, R678Q, V697L, T733I, L755S, L755P, E757A, D769H, D769Y, D769N, G776V, G776C, V777L, L841V, V842I, R849W, L869R, R896C); insertions/deletions (A775_G776insYVMA aka Y772_A755dup, G776VinsC, G776AinsVGC, G776 insertions, G778_S779insCPG, P780_781insGSP aka G778_P780dup, L755_T759del) and/or HER3 activating mutations; there is no limitation on the number of prior lines of systemic therapy or HER2-targeted therapies (prior neratinib not allowed)
* Both measurable as well as non-measurable disease will be allowed
* Hemoglobin \>= 9 g/dL (after transfusion, if necessary) within 4 weeks of pre-registration
* Total bilirubin within normal institutional limits within 4 weeks of pre-registration
* Aspartate aminotransferase (AST) (serum glutamic oxaloacetic transaminase \[SGOT\])/alanine aminotransferase (ALT) (serum glutamate pyruvate transaminase \[SGPT\]) =\< 2.5 x institutional upper limit of normal within 4 weeks of pre-registration
* Creatinine clearance \>= 30 mL/min as calculated by Cockcroft-Gault formula within 4 weeks of pre-registration
* Baseline left ventricular ejection fraction LVEF \>= 50% as evaluated by echocardiogram (ECHO) or multiple-gated acquisition scan (MUGA)
* All grade \>= 2 toxicities other than alopecia from prior therapy have resolved by the time of study commencement
* Patient must have completed radiation therapy with adequate recovery of bone marrow and organ functions, before starting neratinib
* Patient with stable or treated brain metastases are eligible; asymptomatic patients with metastatic brain disease who have been on a stable dose of corticosteroids for treatment of brain metastases for at least 14 days are eligible to participate in the study
* Provide written, informed consent to participate in the study and follow the study procedures

Exclusion Criteria:

* Prior treatment with neratinib
* Concurrent usage of other investigational agents, chemotherapy, or hormone therapy; prior chemotherapy, hormonal therapy, targeted therapy, and investigational agents are allowed but all toxicities grade \>= 2 must have resolved by the time of study commencement (except alopecia)
* Any major surgery =\< 28 days prior to the initiation of investigational products
* Received chemotherapy or biologic therapy =\< 3 weeks prior to the start of neratinib
* Active uncontrolled cardiac disease, including cardiomyopathy, congestive heart failure (New York Heart Association functional classification of \>= 2, including individuals who currently use digitalis specifically for congestive heart failure), unstable angina, myocardial infarction within 12 month of enrollment or ventricular arrhythmia
* Concurrent use of digoxin due to cardiac disease; corrected QT (QTc) interval \>= 450 milliseconds in men and \>= 470 milliseconds in women within 2 weeks of registration or known history of QTc prolongation or Torsades de Pointes
* Inability to take oral medication
* Other malignancy within the past 3 years with the exception of: a) adequately treated basal cell carcinoma, squamous cell skin cancer, or thyroid cancer; b) cervix or vulva carcinoma in situ; c) cancer considered cured by surgical resection or unlikely to impact survival during the duration of the study, such as localized transitional cell carcinoma of the bladder, or benign tumors of the adrenal or pancreas
* Significant chronic gastrointestinal disorder with diarrhea as a major symptom (e.g., Crohn?s disease, malabsorption, or grade \>= 2 National Cancer Institute \[NCI\] Common Terminology Criteria for Adverse Events \[CTCAE\] v.4.0 diarrhea of any etiology at baseline)
* Known clinically active infection with hepatitis B or hepatitis C virus
* Evidence of significant medical illness, abnormal laboratory finding or psychiatric illness/social situations that would, in the investigator?s judgment, makes the patient inappropriate for this study

Primary outcomes:
measure: Percent of Participants With Grade 2 or Higher Toxicities
timeFrame: On treatment, 28 days per cycle up to 1 year
Secondary outcomes:
measure: Count of Participants With Grade 3 or Higher Gastrointestinal (GI) Toxicities Such as Diarrhea, Nausea and Vomiting
timeFrame: On treatment, 28 days per cycle up to 1 year
measure: Rate of Participants With a Dose Reduction
timeFrame: On treatment, up to 48 months
measure: Rate of Participants Requiring Hospitalizations
timeFrame: On treatment, up to 48 months
measure: Tumor Response Using Response Evaluation Criteria in Solid Tumors (RECIST)
timeFrame: Participants are evaluated every 12 weeks, up to 48 months
measure: Median Progression-free Survival (PFS) in Months
timeFrame: From the date treatment begins until the first date on which recurrence, progression or death due to any cause, assessed up to 48 months
measure: Median Overall Survival (OS)
timeFrame: Time from start of treatment to death due to any cause, assessed up to 48 months
measure: Cancer-specific Geriatric Assessment Score
timeFrame: At day 0 of treatment
measure: Pharmacokinetics of Steady State Neratinib Concentration Transformed Using a Logarithm Base 2
timeFrame: Day 0 to day 15
Other outcomes:
Locations:
city: Corona
country: United States
facility: City of Hope Corona
state: California
city: Duarte
country: United States
facility: City of Hope Medical Center
state: California
city: Lancaster
country: United States
facility: City of Hope Antelope Valley
state: California
city: Mission Hills
country: United States
facility: City of Hope Mission Hills
state: California
city: Rancho Cucamonga
country: United States
facility: City of Hope Rancho Cucamonga
state: California
city: South Pasadena
country: United States
facility: City of Hope South Pasadena
state: California
city: West Covina
country: United States
facility: City of Hope West Covina
state: California
Study officials:
affiliation: City of Hope Medical Center
name: Mina Sedrak, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Wong CW, Yost SE, Lee JS, Gillece JD, Folkerts M, Reining L, Highlander SK, Eftekhari Z, Mortimer J, Yuan Y. Analysis of Gut Microbiome Using Explainable Machine Learning Predicts Risk of Diarrhea Associated With Tyrosine Kinase Inhibitor Neratinib: A Pilot Study. Front Oncol. 2021 Mar 10;11:604584. doi: 10.3389/fonc.2021.604584. eCollection 2021.
citation: Yuan Y, Lee JS, Yost SE, Stiller T, Blanchard MS, Padam S, Katheria V, Kim H, Sun C, Tang A, Martinez N, Patel ND, Sedrak MS, Waisman J, Li D, Sanani S, Presant CA, Mortimer J. Phase II study of neratinib in older adults with HER2 amplified or HER2/3 mutated metastatic breast cancer. J Geriatr Oncol. 2021 Jun;12(5):752-758. doi: 10.1016/j.jgo.2021.02.020. Epub 2021 Mar 2.