Clinical trial NCT00268775: Implementation Strategies for a Simple Intervention to Reduce Longterm Benzodiazepine Use in Dutch Community Pharmacies
Official title: Implementation Strategies Aimed at a Simple Patient-directed Intervention to Reduce Long-term Use of Benzodiazepines in Dutch Community Pharmacies
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Benzodiazepines Therapeutic Use
Keywords: community pharmacy services
patient care
outcome assessment
benzodiazepines therapeutic use
Lead sponsor: Radboud University Medical Center
Sponsor class: OTHER
Collaborators: name: Zorgverzekeraar CZ
name: Scientific Institute for Dutch Pharmacists, The Netherlands
First posted: 2005-12-22
Enrollment: 20000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP

Brief summary: The purpose of this study is to compare the effect of two implementation strategies for a simple patient-directed intervention to reduce long-term benzodiazepine use in Dutch community pharmacies.

Detailed description: In Dutch community pharmacies many projects have been undertaken in the field of pharmaceutical care, with mixed results. It is not yet clear which elements exactly contribute to the success of these projects and to implementation of pharmaceutical care.

One of the subjects to which attention is paid in community pharmacies, is the undesirable long-term use of benzodiazepines. Treatment methods for discontinuation of long-term benzodiazepine use have been studied rather extensively. A simple patient-directed discontinuation letter proved to be effective in several studies.

Comparison: a minimal intervention group (pharmacists carrying out the intervention guided by a manual only) compared to a maximal intervention group (pharmacists receiving a manual, a training aimed at better cooperation and communication with family practitioners and some support in the management of the project).

Eligibility criteria: Inclusion Criteria:

* benzodiazepine use for more than 3 months in the last 12 months AND for more than 60 days in the last 2 months

Exclusion Criteria:

* treatment by psychiatrist, treatment of alcohol- or drug misuse, psychotic episodes in history, epilepsy, terminal disease, not mastering the Dutch language, individual criteria used by the family practitioner

Primary outcomes:
measure: percentage of general practitioners that reviewed and returned the list of longterm users.
measure: percentage of letters sent by the pharmacists in the four months after receiving the manual.
measure: percentage of long-term benzodiazepine users that managed to quit or significantly reduce their use in months 0-3, 4-6 and 10-12 after receiving the letter.
Secondary outcomes:
measure: evaluation of the implementation strategies
Other outcomes:
Locations:
city: Asten
country: Netherlands
facility: Apotheek Asten
city: Bakel
country: Netherlands
facility: Apotheek Bakel-Milheeze
city: Bergeyk
country: Netherlands
facility: Kring-apotheek Bergeyk
city: Berlicum
country: Netherlands
facility: Apotheek Berlicum
city: Best
country: Netherlands
facility: Lloyds Apotheek van Kollenburg
city: Best
country: Netherlands
facility: Apotheek de Schakel
city: Best
country: Netherlands
facility: Apotheek Heivelden
city: Beuningen
country: Netherlands
facility: Apotheek Blanckenburgh
city: Bladel
country: Netherlands
facility: Apotheek Bladel
city: Bocholtz
country: Netherlands
facility: Apotheek Bocholtz
city: Brunssum
country: Netherlands
facility: Apotheek van de Wouw
city: Budel
country: Netherlands
facility: Apotheek Budel
city: Den Bosch
country: Netherlands
facility: Apotheek Schellekens
city: Den Bosch
country: Netherlands
facility: Apotheek Cleij
city: Den Bosch
country: Netherlands
facility: Apotheek Empel
city: Deurne
country: Netherlands
facility: Apotheek in 't Groen
city: Deurne
country: Netherlands
facility: Apotheek Koolen-Motké
city: Deurne
country: Netherlands
facility: Apotheek de Schelde
city: Druten
country: Netherlands
facility: Apotheek Druten
city: Eersel
country: Netherlands
facility: Apotheek de Kempen
city: Elsloo
country: Netherlands
facility: Apotheek Elsloo
city: Ewijk
country: Netherlands
facility: Apotheek Ewijk
city: Eygelshoven
country: Netherlands
facility: Apotheek Eygelshoven
city: Geldrop
country: Netherlands
facility: Lloyds Apotheek Geldrop
city: Gemert
country: Netherlands
facility: Apotheek het Frans Brugske
city: Gemert
country: Netherlands
facility: Apotheek Lindner
city: Gennep
country: Netherlands
facility: Apotheek de Duivenakker
city: Gennep
country: Netherlands
facility: Apotheek Gennep
city: Goes
country: Netherlands
facility: Apotheek de Pijlers
city: Goes
country: Netherlands
facility: Zeeuwse Apotheek
city: Goes
country: Netherlands
facility: Apotheek de Goese Polder
city: Groesbeek
country: Netherlands
facility: Apotheek Groesbeek
city: Hapert
country: Netherlands
facility: Linde apotheek
city: Heeswijk-Dinther
country: Netherlands
facility: Apotheek Heeswijk-Dinther
city: Helmond
country: Netherlands
facility: Apotheek Tendijck
city: Helmond
country: Netherlands
facility: Service Apotheek de Bus
city: Helmond
country: Netherlands
facility: Service apotheek Vondellaan
city: Helmond
country: Netherlands
facility: Apotheek de Luifel
city: Helmond
country: Netherlands
facility: Apotheek Brouwhuis
city: Helmond
country: Netherlands
facility: Kring-apotheek de Rijpel
city: Herkenbosch
country: Netherlands
facility: Lloyds Apotheek Herkenbosch
city: Herten
country: Netherlands
facility: Apotheek Hegtermans
city: Herten
country: Netherlands
facility: Apotheek Herten-Merum
city: Kerkrade
country: Netherlands
facility: apotheek Kerkrade-centrum
city: Kerkrade
country: Netherlands
facility: Apotheek Schonefeld
city: Kerkrade
country: Netherlands
facility: Apotheek Bleijerheide
city: Kerkrade
country: Netherlands
facility: Apotheek Medische Centrum West Kerkrade
city: Kerkrade
country: Netherlands
facility: Apotheek Terwinselen
city: Landgraaf
country: Netherlands
facility: Apotheek Waubach
city: Landgraaf
country: Netherlands
facility: Apotheek Landgraaf
city: Landgraaf
country: Netherlands
facility: Apotheek MC Putstraat
city: Landgraaf
country: Netherlands
facility: Apotheek Schaesberg
city: Landgraaf
country: Netherlands
facility: Apotheek Nieuwenhagen
city: Maarheeze
country: Netherlands
facility: Apotheek Maarheeze
city: Maasbracht
country: Netherlands
facility: Apotheek Craveld
city: Maasbracht
country: Netherlands
facility: Apotheek Maasbracht
city: Malden
country: Netherlands
facility: Service apotheek Malden
city: Meerlo
country: Netherlands
facility: Apotheek Maasdorpen
city: Melick
country: Netherlands
facility: Lloyds Apotheek de Roerstreek
city: Middelburg
country: Netherlands
facility: Apotheek Ringeling
city: Middelburg
country: Netherlands
facility: Apotheek Hummelen
city: Middelburg
country: Netherlands
facility: Apotheek Stromenwijk 't Zand
city: Middelburg
country: Netherlands
facility: Apotheek Welsinge
city: Middelburg
country: Netherlands
facility: Apotheek Dauwendaele
city: Nijmegen
country: Netherlands
facility: Apotheek van der Ploeg
city: Nijmegen
country: Netherlands
facility: Kring-apotheek Beckers
city: Oost-Souburg
country: Netherlands
facility: Apotheek Souburg
city: Posterholt
country: Netherlands
facility: Lloyds Apotheek Postert
city: Reusel
country: Netherlands
facility: Apotheek Reusel
city: Roermond
country: Netherlands
facility: Lloyds Apotheek Clemens-Haan
city: Roermond
country: Netherlands
facility: Reinald apotheek
city: Roermond
country: Netherlands
facility: Apotheek Hendrickx-Maasniel
city: Roermond
country: Netherlands
facility: Lloyds Apotheek Donderberg
city: Roermond
country: Netherlands
facility: Apotheek Roermond Zuid
city: Rosmalen
country: Netherlands
facility: Apotheek Rosmalen-Walschot
city: Rosmalen
country: Netherlands
facility: Apotheek Rosmalen
city: Simpelveld
country: Netherlands
facility: apotheek Simpelveld-Bocholtz
city: Sint Michielsgestel
country: Netherlands
facility: Apotheek Hopveld
city: Sittard
country: Netherlands
facility: Apotheek de Baandert
city: Tilburg
country: Netherlands
facility: Wandelbos Apotheek
city: Valkenswaard
country: Netherlands
facility: Apotheek de Belleman
city: Valkenswaard
country: Netherlands
facility: Apotheek Valkenswaard
city: Valkenswaard
country: Netherlands
facility: Apotheek Vlaslant
city: Valkenswaard
country: Netherlands
facility: Apotheek Dommeldal
city: Veghel
country: Netherlands
facility: apotheek 't Zuid
city: Veldhoven
country: Netherlands
facility: Veldhovense Apotheek
city: Veldhoven
country: Netherlands
facility: Apotheek Zonderwijk
city: Wijchen
country: Netherlands
facility: Apotheek van Poppel
city: Wijchen
country: Netherlands
facility: Apotheek Dr. H. Kilian
city: Wijchen
country: Netherlands
facility: Apotheek Wijchen-Zuid
Study officials:
affiliation: Scientific Institute for Dutch Pharmacists, The Netherlands
name: Peter G de Smet, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Centre for Quality of Care Research Nijmegen
name: Michel Wensing, PhD
role: STUDY_DIRECTOR
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