Clinical trial NCT01267851: Clinical Database and Biobank of Patients With Gynecologic Neoplasms
Official title: A Large Multicentre Clinical Database and Biobank of Patients With Gynecologic Neoplasms
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Cervical Cancer
Ovarian Cancer
Endometrial Cancer
Choriocarcinoma
Uterine Myoma
Endometriosis
Keywords: gynecologic disease
Lead sponsor: Huazhong University of Science and Technology
Sponsor class: OTHER
Collaborators: name: Zhejiang University
name: Hunan Province Tumor Hospital
name: Guangxi Medical University
name: First Affiliated Hospital Xi'an Jiaotong University
name: West China Second University Hospital
name: Obstetrics & Gynecology Hospital of Fudan University
name: Shanghai First Maternity and Infant Hospital
name: Peking University People's Hospital
name: Wuhan Central Hospital
First posted: 2010-12-29
Enrollment: 1600000
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: gynecologic diseases, such as cervical cancer, ovarian cancer, endometrial cancer, choriocarcinoma, uterine myoma, endometriosis, as well as part of population-based healthy women

Brief summary: The database and biobank establishment started in 1997 in our institute. However, the sample size was too small with respect to our clinical and fundamental scientific research's requirement. Thus the Chinese gynecological oncology study (GOS) group was established to create a large multicentre database and biobank of patients with gynecologic diseases.

Detailed description: The database contains clinical and epidemiologic information about patients with gynecologic neoplasms, such as cervical carcinoma, ovarian carcinoma, etc. With the data gathered from this database, the investigators could further demonstrate the etiology, risk factor, clinical treatment, and other aspects of the complicated gynecologic diseases. The cervical cancer database v1.10 including more than 10,000 cases and more than 200 variables has been established.

The biobank collects blood, fluids, tissue samples, and related clinical data from consenting patients with gynecologic neoplasms, such as cervical cancer, ovarian cancer, endometrial cancer, choriocarcinoma, uterine myoma, endometriosis. Besides, blood samples of population-based healthy people with informed consent are also collected.

Eligibility criteria: Inclusion Criteria:

* patients with informed consent;
* patients with gynecologic diseases;
* patients with intact clinical and pathological information

Exclusion Criteria:

* not included in the inclusion criteria

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Wuhan
country: China
facility: Tongji Hospital of HUST
state: Hubei
Study officials:
References:
citation: Hu T, Li S, Chen Y, Shen J, Li X, Huang K, Yang R, Wu L, Chen Z, Jia Y, Wang S, Cheng X, Han X, Lin Z, Xing H, Qu P, Cai H, Song X, Tian X, Xu H, Xu J, Zhang Q, Xi L, Deng D, Wang H, Wang S, Lv W, Wang C, Xie X, Ma D. Matched-case comparison of neoadjuvant chemotherapy in patients with FIGO stage IB1-IIB cervical cancer to establish selection criteria. Eur J Cancer. 2012 Oct;48(15):2353-60. doi: 10.1016/j.ejca.2012.03.015. Epub 2012 Apr 13.