Clinical trial NCT06845683: Effects of Dual-Task and Progressive Wall Squat Training in Stroke Survivors
Official title: Effects of Dual-Task and Progressive Wall Squat Training on Cognition, Balance and Functional Mobility in Stroke Survivors
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Stroke Ischemic
Keywords: Balance
cognition
dual-task
functional mobility
stroke survivors
wall squat
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2025-02-25
Enrollment: 50
Sex: ALL
Minimum age (years): 45
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Assignment
Primary purpose: TREATMENT

Brief summary: To determine the Effects of Dual-Task and Progressive Wall Squat Training on Cognition, Balance and Functional mobility in Stroke Survivors.

Detailed description: A stroke is a neurological disorder in which clots or ruptured vessels obstruct blood vessels, causing abnormal blood flow in the brain. This may lead to the unexpected death of brain cells and aggravate illnesses like depression and dementia.It is a disease with significant health and social consequences because of its high frequency and rate. Stroke is thought to affect 9.2% of the population in Europe, with a rate of 191.9 per 100,000 people annually. According to estimates, between 25 and 74% of those who survive this illness need assistance or become totally reliant on their everyday activities.The primary long-term effects of a stroke are dysphagia, paralysis, motor impairments, cognitive decline, and speech difficulties.

Dual-task training entails doing a motor task and a cognitive task at the same time. This method's justification is that a lot of daily tasks necessitate multitasking, and dual-task training can improve both cognitive and motor abilities by promoting brain plasticity and the interaction of the two systems. In the dual task training, cognitive task (like naming animals or counting backwards) is combined with a lower limb strengthening exercise called wall squats. Both tasks gradually increase in difficulty and intensity based on how well each person performs. By testing the muscle strength, endurance, and coordination of stroke survivors as well as their attention, memory, and executive function, this training seeks to improve their cognitive abilities, balance, and functional mobility.

Eligibility criteria: Inclusion Criteria:

* Age: Stroke patients aged 45 to 65 years.
* Individuals with a single ischemic stroke.
* Within the first 2 months post-stroke. (Subacute stage)
* Medically stable without acute conditions interfering with exercise.
* Mini-Mental State Examination (MMSE) score≥24
* Ability to walk 10m without assistance

Exclusion Criteria:

* Unstable Medical Conditions (cardiovascular, respiratory, or other medical conditions)
* Recent Stroke or Medical Event
* Other Neurological Conditions such as Presence of other neurological conditions (e.g., Parkinson's disease).
* Uncontrolled Hypertension: Systolic BP \>160 mm Hg or diastolic BP \>100 mm Hg

Primary outcomes:
measure: MOCA (Montreal Cognitive Assessment)
timeFrame: 8 weeks
measure: Tinneti POMA (Balance, gait)
timeFrame: 8 weeks
measure: Rivermead mobility index
timeFrame: 8 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Society Hospital
state: Punjab
Study officials:
affiliation: Riphah International University Pakistan
name: Aruba Saeed, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Morice E, Moncharmont J, Jenny C, Bruyneel AV. Dancing to improve balance control, cognitive-motor functions and quality of life after stroke: a study protocol for a randomised controlled trial. BMJ Open. 2020 Sep 30;10(9):e037039. doi: 10.1136/bmjopen-2020-037039.
citation: Buvarp D, Rafsten L, Sunnerhagen KS. Predicting Longitudinal Progression in Functional Mobility After Stroke: A Prospective Cohort Study. Stroke. 2020 Jul;51(7):2179-2187. doi: 10.1161/STROKEAHA.120.029913. Epub 2020 Jun 17.
citation: Lee Y, Kim K. The influence of Gait Training Combined with Portable Functional Electrical Stimulation on motor function, balance and gait ability in stroke patients. J Back Musculoskelet Rehabil. 2022;35(6):1171-1178. doi: 10.3233/BMR-210154.
citation: Hurd MD, Goel I, Sakai Y, Teramura Y. Current status of ischemic stroke treatment: From thrombolysis to potential regenerative medicine. Regen Ther. 2021 Oct 12;18:408-417. doi: 10.1016/j.reth.2021.09.009. eCollection 2021 Dec.
citation: Spano B, Lombardi MG, De Tollis M, Szczepanska MA, Ricci C, Manzo A, Giuli S, Polidori L, Griffini IA, Adriano F, Caltagirone C, Annicchiarico R. Correction: Spano et al. Effect of Dual-Task Motor-Cognitive Training in Preventing Falls in Vulnerable Elderly Cerebrovascular Patients: A Pilot Study. Brain Sci. 2022, 12, 168. Brain Sci. 2024 Apr 11;14(4):370. doi: 10.3390/brainsci14040370.
citation: Kuriakose D, Xiao Z. Pathophysiology and Treatment of Stroke: Present Status and Future Perspectives. Int J Mol Sci. 2020 Oct 15;21(20):7609. doi: 10.3390/ijms21207609.