Clinical trial NCT06621628: Polarized Light Therapy in Patients With CREST Syndrome.
Official title: Polarized Light Therapy and Hand Grip Strengthening Exercises in Patients With CREST Syndrome.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: CREST Syndrome
Keywords: Polarized light therapy
Resisted exercise
CREST syndrome
Modified Rodnon skin score
and Hand Grip Dynamometer
Lead sponsor: New Ismailia National University
Sponsor class: OTHER
First posted: 2024-10-01
Enrollment: 60
Sex: ALL
Minimum age (years): 16
Maximum age (years): 21
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: to evaluate the efficacy of the Polarized light therapy and Hand Grip Strengthening exercises in patients with CREST syndrome.
Primary purpose: TREATMENT

Brief summary: to evaluate the efficacy of the Polarized light therapy and Hand Grip Strengthening exercises in patients with CREST syndrome

Detailed description: Measurement of the skin thickness via the modified Rodnon skin score (RSS) and Hand Grip Dynamometer (HGD) . Methods:- Sixty patients, who had hand involvement of patients with CREST syndrome, were participated in the study. Their ages were ranged from 16 to 45 years. The participants were selected from the dermatology departments of Cairo university hospitals and Om El-Misrieen hospital, randomly distributed into three equal groups. Group A: (Study group): This group included 20 patients who had CREST syndrome with scleroderma in the dorsum of hands and who received the BLT with traditional physical therapy program (stretching, strengthening and active exercise) patients received 3 sessions per week for 12 weeks (3 months),time of session is 15 minutes. Group B: This group included 20 patients who have CREST syndrome with scleroderma in the dorsum of hands and who received resisted exercise with traditional physical therapy program (stretching, strengthening and active exercise) patients received 3 sessions per week for 12 weeks (3 months), time of session is 15 minutes and Group C:This group included 20 patients who had CREST syndrome with scleroderma in the dorsum of hands and who received combination of (BLT and resisted exercise) with traditional physical therapy program (stretching, strengthening and active exercise) exercise program (stretching, strengthening and active exercise).patients received 3 sessions per week for 12weeks (3 months), time of session was 15 minutes.

Eligibility criteria: Inclusion Criteria:

* The patients' ages ranged from 16 to 21 years.
* Patients who had hand involvement of patients with CREST syndrome particularly dorsum of the hand.
* All patients were conscious.
* All patients were randomly chosen (male and female).

Exclusion Criteria:

* Patients who are diabetic or hypertensive.
* Patients those familiar with the BLT and resisted exercise via the hand grip strengthener.
* Patients with hemorrhage specially hemorrhage of digestive system and those with bleeding per rectum.
* Patients with severe fungal diseases and acute viral diseases.
* Patients with active tuberculosis and tumors as well as those with peacemakers.
* Patients with polyneuropathy.
* Patients with thyroid problems

Primary outcomes:
measure: skin thickness
timeFrame: 12 weeks
measure: hand grip strength and pinch gauge
timeFrame: 12 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Ismailia
country: Egypt
facility: Khadra Mohamed Ali
city: Ismailia
country: Egypt
facility: Mohamed Abdel Moenem Abo El Ros
Study officials:
affiliation: Cairo University
name: Zakaria E Mowafy, Ph.D
role: STUDY_DIRECTOR
References: