Clinical trial NCT05567549: Evaluation of Sarcopenia in Elderly at the Emergency Department
Official title: Frequency of Sarcopenia and Relation With Mortality in Elderly at the Emergency Department
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Sarcopenia
Lead sponsor: Ege University
Sponsor class: OTHER
First posted: 2022-10-05
Enrollment: 300
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Observational model: CASE_ONLY
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients over 65 years of age, who can walk independently, who do not have lower extremity fractures or neuromuscular disease, will constitute the study population.

The mortality rate over the age of 65 was found to be 11%. Considering that the mortality rate with sarcopenia was 28%, it was found that 63 patients were required for the effect of sarcopenia on mortality with a 95% confidence interval and 0.5% margin of error. Since the incidence of sarcopenia in the emergency department was 33%, 200 patients were planned to be included in the study.

Brief summary: The goal of this observational study is to evaluate in elderly patients for the frequency of sarcopenia and its relationship with mortality in a university hospital.

The main questions it aims to answer are;

1. What is the frequency of sarcopenia in elderly patients at emergency department?
2. Is sarcopenia associated with mortality in an elderly patient admitted to the emergency department?


Eligibility criteria: Inclusion Criteria:

1. Above the age of 65 admitted to the emergency department
2. Able to walk without support
3. No lower extremity fracture
4. No disease with neuromuscular involvement

Exclusion Criteria:

1. In the presence of a cerebrovascular event
2. Those in need of critical intervention when applying to the emergency department
3. Unconscious patients

Primary outcomes:
measure: Mortality
timeFrame: 0-28 days
Secondary outcomes:
Other outcomes:
Locations:
city: İzmir
country: Turkey
facility: Ege University
Study officials:
References:
citation: Morley JE. Sarcopenia: diagnosis and treatment. J Nutr Health Aging. 2008 Aug-Sep;12(7):452-6. doi: 10.1007/BF02982705. No abstract available.
citation: Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, Martin FC, Michel JP, Rolland Y, Schneider SM, Topinkova E, Vandewoude M, Zamboni M; European Working Group on Sarcopenia in Older People. Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing. 2010 Jul;39(4):412-23. doi: 10.1093/ageing/afq034. Epub 2010 Apr 13.
citation: Roberts S, Collins P, Rattray M. Identifying and Managing Malnutrition, Frailty and Sarcopenia in the Community: A Narrative Review. Nutrients. 2021 Jul 5;13(7):2316. doi: 10.3390/nu13072316.
citation: Hung SK, Kou HW, Hsu KH, Wu CT, Lee CW, Leonard Goh ZN, Seak CK, Chen-Yeen Seak J, Liu YT, Seak CJ; SPOT investigators. Sarcopenia is a useful risk stratification tool to prognosticate splenic abscess patients in the emergency department. J Formos Med Assoc. 2021 Mar;120(3):997-1004. doi: 10.1016/j.jfma.2020.08.039. Epub 2020 Sep 9.
citation: McQuade C, Kavanagh DO, O'Brien C, Hunter K, Nally D, Hickie C, Ward E, Torreggiani WC. CT-determined sarcopenia as a predictor of post-operative outcomes in patients undergoing an emergency laparotomy. Clin Imaging. 2021 Nov;79:273-277. doi: 10.1016/j.clinimag.2021.05.015. Epub 2021 May 18.