Clinical trial NCT04709354: Clinical and Dermoscopic Comparison of Rheumatoid Arthritis, Ankylosing Spondylitis and Psoriasis Patients' Nails
Official title: Clinical and Dermoscopic Evaluation of Nail Findings of Rheumatoid Arthritis, Ankylosing Spondylitis and Psoriatic Arthritis Patients and Comparison With Psoriasis Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Psoriasis Circinata
Psoriatic Arthritis
Rheumatoid Arthritis
Spondylarthropathies
Psoriatic Nail
Keywords: Psoriasis
Psoriatic Arthritis
Psoriatic Nail
Dermoscopy
Lead sponsor: Bezmialem Vakif University
Sponsor class: OTHER
First posted: 2021-01-14
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients over 18 years with psoriasis, rheumatoid arthritis, ankylosing spondylitis

Brief summary: This study evaluates the fingernail findings of the rheumatoid arthritis, spondylopathy and psoriatic arthritis patient groups with the fingernails of psoriasis patients clinically and dermatoscopically and investigates the benefit of dermoscopy in the differentiation of these patients.

Detailed description: Psoriasis is a common chronic inflammatory disease with many comorbidities. Dermatologists have a very important role in the early diagnosis of psoriatic arthritis, which is one of the most important comorbidities of psoriasis. Therefore, studies have been conducted on many factors predicting the risk of psoriatic arthritis and it has been concluded that nail involvement is closely related to psoriatic arthritis.For this reason, the importance of nail examination in the follow-up of psoriasis patients has increased significantly. Nail examination should be done carefully to predict the risk of developing psoriatic arthritis, especially at the beginning of the disease and subclinical types, and dermoscopy should be used to identify patients who may be clinically uncertain.

In addition, rheumatoid arthritis and spondylopathy patients have a lot in common with psoriatic arthritis patients.In these patients, there is no clear distinction to diagnose joint involvement, and their distinction is mostly based on the presence or absence of skin findings.Nail findings have an important place among this skin findings in the diagnosis of these patients.

Based on all these, this study questions the benefit of clinical and dermoscopic examination of nail findings in the early stages to differentiate these patients, as well as comparing the nail findings and revealing the differences and similarities.

Eligibility criteria: Inclusion Criteria:

* Psoriasis confirmed by dermatologist.
* Rheumatoid arthritis, ankylosing spondylitis confirmed by rheumatologist (newly diagnosed).

Exclusion Criteria:

* Unable to consent and understand
* Patients with confirmed onychomycosis
* Patients receiving biological therapy

Primary outcomes:
measure: Comparation of clinical features of nails
timeFrame: six months
measure: Comparation of dermoscopic features of nails
timeFrame: six months
measure: NAPSI (Psoriasis Area and Severity index)
timeFrame: six months
measure: PASI (Psoriasis Area and Severity Index)
timeFrame: six months
Secondary outcomes:
measure: Demographic characteristics
timeFrame: through study completion, an average of 6 months
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Bezmialem Vakıf Univesity
Study officials:
affiliation: Bezmialem University
name: Nahide MD Onsun, Prof
role: STUDY_DIRECTOR
affiliation: Bezmialem University
name: Begüm MD Güneş
role: PRINCIPAL_INVESTIGATOR
References:
citation: Yorulmaz A, Artuz F. A study of dermoscopic features of nail psoriasis. Postepy Dermatol Alergol. 2017 Feb;34(1):28-35. doi: 10.5114/ada.2017.65618. Epub 2017 Feb 7.
citation: Wanniang N, Navya A, Pai V, Ghodge R. Comparative Study of Clinical and Dermoscopic Features in Nail Psoriasis. Indian Dermatol Online J. 2020 Jan 13;11(1):35-40. doi: 10.4103/idoj.IDOJ_51_19. eCollection 2020 Jan-Feb.
citation: Zabotti A, Errichetti E, Zuliani F, Quartuccio L, Sacco S, Stinco G, De Vita S. Early Psoriatic Arthritis Versus Early Seronegative Rheumatoid Arthritis: Role of Dermoscopy Combined with Ultrasonography for Differential Diagnosis. J Rheumatol. 2018 May;45(5):648-654. doi: 10.3899/jrheum.170962. Epub 2018 Feb 15.