Clinical trial NCT01554033: Study of Huntington Patients in Connection With European Huntington's Disease Network (EHDN)
Official title: Study of Huntington Patients in Connection With European Huntington's Disease Network (EHDN).
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Huntington Disease
Keywords: European Huntington's Disease Network
Huntington patients in KOREA
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
Collaborators: name: European Huntington's Disease Network
First posted: 2012-03-14
Enrollment: 200
Sex: ALL
Minimum age (years): 1
Maximum age (years): 80
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CROSSOVER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: primary care clinic

Brief summary: REGISTRY is a multi-centre, multi-national, prospective, observational study of Huntington's disease (HD) with a control group of volunteers. It is an open-ended study which will include as many eligible participants as willing to participate. The goal of the project is to collect longitudinal data on the phenotypical characteristics of HD gene mutation carriers regardless of whether they display clinical symptoms and signs of the disease and of individuals who are part of an HD family (irrespective of their mutation carrier status), in order to:

* obtain natural history data on a wide spectrum of HD mutation carriers and individuals who are part of an HD family
* relate phenotypical characteristics

  * with genetic factors ('genetic modifiers')
  * with data derived from the study of body fluids (blood, urine - 'wet biomarker') and
  * imaging data ('dry biomarker')
* expedite identification and recruitment of participants for clinical trials
* develop and validate sensitive and reliable outcome measures for detecting onset and change over the natural course of premanifest and manifest HD which may also be potential outcome measures for use in future clinical trials and clinical care.
* plan for future research studies (observational and interventional trials aimed at better symptom control or aimed at slowing or postponing the onset and progression of HD).

Detailed description: To collect prospective data on the phenotypical characteristics of HD mutation carriers regardless of whether they display clinical symptoms and signs of HD and of individuals who are part of an HD family (irrespective of their mutation carrier status), in order to;

* obtain natural history data on a wide spectrum of HD patients, HD mutation carriers and individuals who are part of an HD family
* relate phenotypical characteristics with

  * genetic factors ('genetic modifiers'),
  * data derived from the study of body fluids (blood, urine - 'wet biomarker') and
  * imaging data ('dry biomarker')
* expedite identification and recruitment of participants for clinical trials
* develop and validate sensitive and reliable outcome measures for detecting onset and change over the natural course of premanifest and manifest HD, and which may also be potential outcome measures for use in future clinical trials and clinical care.
* plan for future research studies (observational and interventional trials aimed at better symptom control or aimed at slowing or postponing the onset and progression of HD).

To achieve these objectives, participants are asked to donate biosamples (blood and urine) for studies to identify genetic modifiers of HD and to establish and validate biological markers tracking the progressive course of HD; in this context a family history is requested as well in order to understand the relationships of clinical data sets and biosamples from related donors. In addition, non-mutation carrying family members of participants are asked to consider donating biosamples to serve as controls.

Eligibility criteria: Inclusion Criteria:

The following individuals may be eligible to participate

* Individuals, confirmed HD mutation carrier
* Manifest HD, without CAG testing
* HD family member at-risk, without CAG testing
* HD family member, non-HD mutation carrier
* REGISTRY-CONTROL participants: companion/individual without HD history
* REGISTRY-COMPANION (any of the above). Participants may be male or female and of any age. All participants must be able to provide consent for themselves, have a parent/guardian who can provide parental permission, or have an authorised legal representative who can provide consent.

Exclusion Criteria:

* Participants who are unable to understand the study protocol or unable to give informed consent, and have no legal representative.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Department of Neurology, Seoul National University Hospital
Study officials:
affiliation: Department of Neurology, Seoul National University Hospital
name: Kim Manho, MD, PhD
role: STUDY_CHAIR
References: