Clinical trial NCT04516798: The Reflex Mechanism Underlying Neuromuscular Effects Of The Whole Body Vibration
Official title: The Reflex Mechanism Underlying The Neuromuscular Effects Of The Whole Body Vibration
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Reflex, Ankle, Decreased
Keywords: whole body vibration
tonic vibration reflex
muscle spindle
Lead sponsor: Istanbul Physical Medicine Rehabilitation Training and Research Hospital
Sponsor class: OTHER_GOV
First posted: 2020-08-18
Enrollment: 8
Sex: ALL
Minimum age (years): 20
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Self controlled experimental study
Primary purpose: BASIC_SCIENCE

Brief summary: This study was conducted to determine whether the spinal reflex mechanism underlying the neuromuscular effects of whole body vibration (WBV) is tonic vibration reflex. Local and whole body vibration reflex latencies were measured in young adult healthy volunteers.

Detailed description: A total of eight volunteers were included according to the inclusion and exclusion criteria. The subjects were vibrated while standing upright with the WBV device (PowerPlate® Pro5). The 30, 35 and 40 Hz WBVs were applied for thirty seconds for each frequency with an amplitude of 2 mm. In the same session, 100, 135 and 150 Hz local vibrations were applied to the right Achilles tendon for thirty seconds for each frequency. 100, 135 and 150 Hz local vibrations were then applied to the right heel for thirty seconds for each frequency with an interval of five seconds. Vibration stimuli were recorded accelerometers. Reflex muscle responses were recorded from the right soleus muscle at a sampling rate of 40 KHz. Recording electrodes were placed on the belly of the right soleus muscle and the ground electrode was placed on the right medial malleolus.

The data were recorded with the PowerLab device, the records were processed and analyzed offline from the LabChart program. After the EMG records are filtered and rectified, reflex latencies were measured by cumulative averaging method using the accelerometer records as triggers (Karacan I, Cakar HI, Sebik O, Yilmaz G, Cidem M, Kara S, Türker KS.A new method to determine reflex latency induced by high rate stimulation of the nervous system.Front Hum Neurosci.2014 Jul 18; 8: 536.doi: 10.3389 / fnhum.2014.00536). After determining the Achilles tendon vibration reflex latency and the reflex latency induced by WBV, it was compared with statistical methods.

Eligibility criteria: Inclusion Criteria:

* Healthy
* Young adult (20-40 years old)
* Both gender
* Volunteer

Exclusion Criteria:

* Cardiac disorder (Rhythm / conduction disorder, Cardiac pacemaker, Ischemic heart disease)
* Finding or suspected active deep vein thrombosis,
* History of deep vein thrombosis and pulmonary embolism,
* Orthostatic hypotension
* Hypertension
* Presence of fracture in the lower limb
* Achilles Contractures
* Active inflammatory, rheumatological or infectious disease in the lower limb
* Peripheral nerve lesions such as polyneuropathy, radiculopathy in the lower limb
* Those with a history of Achilles tendinopathy / bursitis
* Those with a history of kidney stones
* Patients with dizziness and balance problems,
* Cases with lesions on the skin surface where electrodes were attached
* Those with communication-cooperation problems
* Having a history of panic attacks

Primary outcomes:
measure: reflex latency
timeFrame: during intervention, an average of 8 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: İstanbul
country: Turkey
facility: Istanbul Physical Medicine Rehabilitation Training & Research Hospital
Study officials:
affiliation: Istanbul Physical Medicine Rehabilitation Training & Research Hospital
name: Ilhan Karacan, Assoc Prof
role: PRINCIPAL_INVESTIGATOR
References:
citation: Yildirim MA, Topkara B, Aydin T, Paker N, Soy D, Coskun E, Ones K, Bardak A, Kesiktas N, Ozyurt MG, Celik B, Onder B, Kilic A, Kucuk HC, Karacan I, Turker KS. Exploring the receptor origin of vibration-induced reflexes. Spinal Cord. 2020 Jun;58(6):716-723. doi: 10.1038/s41393-020-0419-5. Epub 2020 Jan 15.
citation: Aydin T, Kesiktas FN, Baskent A, Karan A, Karacan I, Turker KS. Cross-training effect of chronic whole-body vibration exercise: a randomized controlled study. Somatosens Mot Res. 2020 Jun;37(2):51-58. doi: 10.1080/08990220.2020.1720635. Epub 2020 Feb 5.
citation: Karacan I, Cakar HI, Sebik O, Yilmaz G, Cidem M, Kara S, Turker KS. A new method to determine reflex latency induced by high rate stimulation of the nervous system. Front Hum Neurosci. 2014 Jul 18;8:536. doi: 10.3389/fnhum.2014.00536. eCollection 2014.