Clinical trial NCT05525728: Integrative Study of Vestibular Pathology
Official title: Integrative Study of Vestibular Pathology With Analysis of Postural, Neurosensory, and Cognitive Disorders: Search for New Markers on the Causes and Consequences of Vertigo
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Dizziness; Syndrome
Keywords: posture
vertigo
cognition
emotion
physiotherapist
vestibular system
balance
Lead sponsor: University Hospital, Caen
Sponsor class: OTHER
First posted: 2022-09-02
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: a group of patient suffering from vestibular pathology will be investigated regardless the etiology of the vertigo or dizziness
Primary purpose: DIAGNOSTIC

Brief summary: Exploratory posturological, neurosensory, cognitive, emotional, personality and general evaluations (quality of life).

The investigators will characterize a sensory profile quantified by one or more scores from a multi-parameter baysian approach. Each parameter and these scores will be correlated to the type of vestibular damage and its recovery in order to establish diagnostic, prognostic and therapeutic follow-up markers.

Detailed description: This is an exploratory neurophysiological work that aims to identify diagnostic, prognostic and therapeutic markers in vestibular pathology.

Theinvestigators wish to characterize the neurosensory profile of individuals using new exploration paradigms provided by a new posturology platform coupled with virtual reality scenarios and by proposing a complete transversal approach in terms of evaluation of the subjects: personality, cognition, emotion including the depressive state, sensory strategy, general data.

Baysian statistical approaches and linear mixed model will be used to determine markers of sensory profile correlated to the vestibular damage for diagnostic, prognostic and therapeutic follow-up.

The investigators aim to be able to better characterize the cognitive-emotional and sensory deficits expressed by the vertiginous and unstable patients, to integrate it into the evaluation of the vestibular pathology, to use these markers to better discriminate the underlying physiopathological mechanisms, and to improve at the same time the diagnosis of the functional attack and the rehabilitation follow-up of the patients.

Eligibility criteria: Inclusion Criteria:

* Male or female patient (18-80 years old)
* Patient with an acute or chronic vestibular pathology according to ENT diagnostic criteria

Exclusion Criteria:

* Subjects under 18 years of age
* Pregnant or breastfeeding women,
* Persons in an emergency situation or unable to give their consent, including adults under guardianship
* Person under legal protection
* Patient presenting a vertigo or postural disorders of non vestibular etiology
* Persons deprived of liberty, minors, protected adults,
* Patients with an intercurrent neurological pathology including cerebellar pathology
* Inclusion of the subject in another interventional research protocol with pharmacological aim during the present study

Primary outcomes:
measure: Posture
timeFrame: through follow-up, an average of 6 months
measure: Cognition
timeFrame: through follow-up, an average of 6 months
measure: Personnality characteristic
timeFrame: through follow-up, an average of 6 months
measure: Sleep
timeFrame: through follow-up, an average of 6 months
measure: Emotion
timeFrame: through follow-up, an average of 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Caen
country: France
facility: Caen University Hospital
city: Vitrolles
country: France
facility: Frédéric Xavier
Study officials:
References: