Clinical trial NCT03291561: Perioperative Electroacupuncture After Operation
Official title: Effect of Perioperative Electroacupuncture After Operation for Pancreatic Cancer and Periampullary Carcinoma Patients: A Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Acupuncture
Gastrointestinal Function
Lead sponsor: Cancer Institute and Hospital, Chinese Academy of Medical Sciences
Sponsor class: OTHER
First posted: 2017-09-25
Enrollment: 400
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Evaluate the effect of perioperative electroacupuncture on rapid rehabilitation for the pancreatic cancer and periampullary carcinoma patients after operation .

Detailed description: The trial is funded by Cancer Foundation of China. The trial is prepared to be registered on the clinicaltrail.gov. Quality assurance plan: every participant is enrolled or excluded by two practiced investigators. And two investigators participated in all steps of the trail, including the record of the data, and the investigators will compare the data. If the data is consistent, the investigators would record the data; if not, the data would be checked and decided by the two investigators. All the steps and data are site monitored and audited by the workers of research and financial department of National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences.

Data check: the investigators compare data entered into the registry against predefined rules for range or consistency with other data fields in the registry. Source data verification to assess the accuracy, completeness, or representativeness of registry data by comparing the data to external data sources, including medical records and electronic case report forms. Data dictionary that contains detailed descriptions of each variable used by the registry, including the source of the variable, coding information, and normal ranges if relevant.

Standard Operating Procedures to address registry operations and analysis activities, such as participants recruitment, data collection, data management, data analysis, reporting for adverse events, and change management. All registry operations would be done according to specific steps, and by two practiced investigators. Sample size assessment to specify the number of participants or participant years necessary to demonstrate an effect. According to the formula to differ advantages and disadvantages, the investigators need at least 400 participants to take part in the trail.

The investigators can recruit about 200 participants every year according to previous experiences, so the investigators should recruit at least for two years. Plan for missing data: the investigators would collect as much data as possible, and the investigators exclude the participants who cannot cooperate on recruitment. And the investigators manage situations according to statistical principles where variables are reported as missing, unavailable, "non-reported," uninterpretable, or considered missing because of data inconsistency or out-of range results. Statistical analysis plan: Kaplan-Meier method would be used to analyze the difference of survival time between the two groups, and the local control rate of the two groups would be compared by chi square test. Statistical analyses would be performed by using IBM SPSS Statistics(version 20; IBM, Chicago, USA). The level of significance is defined as P \< 0.05.

Eligibility criteria: Inclusion Criteria:

1. gastric cancer with gastrectomy
2. less than 3 months life expectancy
3. voluntary and good compliance

Exclusion Criteria:

1. history of abdominal surgery, radiotherapy or chemotherapy
2. metastatic disease.

Primary outcomes:
measure: Gastrointestinal function score
timeFrame: day 1 after surgery
measure: Gastrointestinal function score
timeFrame: day 3 after surgery
measure: Gastrointestinal function score
timeFrame: day 5 after surgery
measure: Gastrointestinal function score
timeFrame: day 7 after surgery
Secondary outcomes:
measure: Physical fitness index
timeFrame: day 1 after surgery
measure: Physical fitness index
timeFrame: day 3 after surgery
measure: Physical fitness index
timeFrame: day 5 after surgery
measure: Physical fitness index
timeFrame: day 7 after surgery
Other outcomes:
Locations:
city: Beijing
country: China
facility: National Cancer Center/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College
state: Beijing
Study officials:
affiliation: Cancer Institute and Hospital, Chinese Academy of Medical Sciences
name: Chengfeng Wang, B.A
role: PRINCIPAL_INVESTIGATOR
References: