Clinical trial NCT05415605: Ultrasound Evaluation of Alveolar Stress by Measurement of Ultrasound Pleural Strain in Healthy Subjects
Official title: Ultrasound Evaluation of Alveolar Stress by Measurement of Ultrasound Pleural Strain in Healthy Subjects
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Ultrasound Strain Measurement
Keywords: lung strain
speckle tracking
lung stress
Lead sponsor: Centre Hospitalier Universitaire de Nīmes
Sponsor class: OTHER
First posted: 2022-06-13
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: OTHER

Brief summary: In the critical patient, lung ultrasound is routinely performed for acute respiratory distress, adult respiratory distress syndrome and for hemodynamic evaluation. Its diagnostic performance is superior to that of chest radiography in the context of pleuropulmonary parenchymal pathologies. The search for lung sliding is performed to diagnose a pneumothorax or to search for the correct placement of the endotracheal intubation tube. However, this analysis is qualitative and is sometimes difficult to interpret. At present, there is no global evaluation technique at the patient's bed allowing to analyze simultaneously the alveolar recruitment, the pulmonary over-distension and the quality of the lung sliding, whereas the pulmonary damage is most often heterogeneous. The justification of our research project is based on the need to develop and validate a means of global and regional quantification of the mechanical and aeration properties of the lung parenchyma by the analysis of the acoustic markers of the pleura (pleural strain) by the ultrasound technique of speckle tracking. The aim is to establish the normal values of the pleural strain in healthy volunteers, in spontaneous ventilation and then in non-invasive mechanical ventilation, in order to vary the lung volume.


Eligibility criteria: Inclusion Criteria:

-Healthy volunteer male or female between 18 and 50 years old

Exclusion Criteria:

* History of traumatic or spontaneous pneumothorax
* History of connective tissue disease
* Any history of chronic respiratory disease
* Presence of an ongoing clinical respiratory Ear-Nose-Throat (ENT) or pulmonary syndrome (rhinitis, sinusitis, bronchitis, lung disease)
* History of gastro-duodenal reflux or stomach surgery

Primary outcomes:
measure: Lung Strain values
timeFrame: during the procedure (30 minutes)
Secondary outcomes:
measure: Ultrasound semiology and normal values
timeFrame: during the procedure (30 minutes)
measure: Variations of the strain under NIV in the different pulmonary zones tested
timeFrame: during the procedure (30 minutes)
measure: Longitudinal and transversal values of lung strain in the different pulmonary zones tested
timeFrame: during the procedure (30 minutes)
measure: Variations of the strain under NIV in the right ventricle
timeFrame: during the procedure (30 min)
measure: Variations of the strain under NIV of the diaphragm
timeFrame: during the procedure (30 minutes)
Other outcomes:
Locations:
city: Nîmes
country: France
facility: CHU de Nîmes, Hôpital Universitaire Carémeau
Study officials:
References: