Clinical trial NCT04022707: High Speed Circuit Training and Cognition
Official title: The Impact of Circuit Resistance Training on Cognition and Estimated Maximal Oxygen Consumption in Older Adults.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Educational Control
Resistance Training
Keywords: Elderly
Circuit training
Cognitive ability
Cardiovascular condition
Lead sponsor: University of Miami
Sponsor class: OTHER
First posted: 2019-07-17
Enrollment: 30
Sex: ALL
Minimum age (years): 60
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Comparison of High-Speed Resistance training and educational control
Primary purpose: TREATMENT

Brief summary: The purpose of this research study is to see if a weight training program can make a positive change in participant fitness as measured by the ability to use oxygen and help the participant remember things.

Detailed description: The purpose of this research study is to see if a weight training program can make a positive change in cardiac fitness, that is a person's ability to use oxygen; and, if the program can help a person's memory, as measured by some standard tests. The researchers will also ask the participant to attend two sessions with researchers at the Bascom-Palmer Eye Institute so they can take pictures of the participants' eyes to see how training changes the number of blood vessels. This can be used by doctors and other clinicians to evaluate improvements blood flow to the brain due to training.

Eligibility criteria: Inclusion Criteria:

1. Men and women between 60 and 85 years of age (inclusive)
2. Ability to provide informed consent
3. No medical contraindication to participation in an exercise program including unstable or active untreated major medical illness (i.e., cardiovascular disease, neurological or neuromuscular diseases, stroke, cancer, etc.).

Exclusion Criteria:

1. Existing muscle-skeletal injury
2. Mini-mental score \<18
3. Enrolled in another exercise program
4. Unstable or active major medical illness
5. Answer "Yes" to any questions on the Elder PAR-Q
6. Pregnancy

Primary outcomes:
measure: Changes in Cognition due to training
timeFrame: Baseline, Week 14
measure: Submaximal cycle ergometer test to measure aerobic capacity
timeFrame: Baseline, Week 14
measure: Change in episodic memory
timeFrame: Baseline, Week 14
measure: Change in attention and inhibitory control
timeFrame: Baseline, Week 14
measure: Change in working memory
timeFrame: Baseline, Week 14
measure: Change in speed of cognitive processing
timeFrame: Baseline, Week 14
measure: Changes in the power muscles can produce
timeFrame: Baseline, Week 14
measure: Change in retinal microvascular density as a marker of cortical changes
timeFrame: Baseline, Week 14
Secondary outcomes:
measure: Changes in body fat-free mass
timeFrame: Baseline, Week 14
measure: Changes in body weight
timeFrame: Baseline, Week 14
Other outcomes:
Locations:
city: Coral Gables
country: United States
facility: Max Orovitz Laboratories
state: Florida
city: Coral Gables
country: United States
facility: Laboratory of Neruomuscular Research and Active Aging
state: Florida
Study officials:
affiliation: University of Miami
name: Joseph Signorile, PhD
role: PRINCIPAL_INVESTIGATOR
References: