Clinical trial NCT05432011: PENG Block Plus Lateral Femoral Cutaneous Nerve Block for Posterolateral-approached Total Hip Arthroplasty
Official title: PENG Block Combined to Lateral Femoral Cutaneous Nerve Block vs. PENG Block Combined to Wound Infiltration for Postoperative Analgesia Following Posterolateral-approached Total Hip Arthroplasty
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pain
Postoperative Pain
Acute Pain
Analgesia
Hip Arthropathy
Postoperative Complications
Lead sponsor: Campus Bio-Medico University
Sponsor class: OTHER
First posted: 2022-06-24
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study aims to analyze the effect of Pericapsular Nerve Group (PENG) Block combined with lateral femoral cutaneous nerve block vs. PENG block combined with wound infiltration for analgesia after elective hip replacement performed with a posters-lateral approach.

Half of participants will receive a PENG Block combined with femoral lateral cutaneous nerve block, while the other half will receive PENG Block combined with wound infiltration


Eligibility criteria: Inclusion Criteria:

* Elective hip replacement surgery performed with a poster-lateral approach
* ASA physical status score \< 4

Exclusion Criteria:

* Contraindications to regional anesthesia
* ASA physical status score ≥ 4
* Patient's refusal or inability to sign the informed consent
* Allergies to any drug provided by the study protocol

Primary outcomes:
measure: Static Pain Score
timeFrame: 24 hours
measure: Dynamic Pain Score
timeFrame: 24 hours
Secondary outcomes:
measure: Morphine consumption
timeFrame: 24 hours
measure: Morphine consumption
timeFrame: 6 days
measure: Range of hip motion
timeFrame: 24 hours
measure: Quadriceps Strength
timeFrame: 24 hours
measure: Ability to start physiotherapy during the first postoperative day
timeFrame: 24 hours
measure: Ability to ambulate with the help of a walker during the first postoperative day
timeFrame: 24 hours
measure: Incidence of block complications
timeFrame: 24 hours
measure: Hospital Length of Stay
timeFrame: 6 days
Other outcomes:
Locations:
city: Rome
country: Italy
facility: Campus Bio-medico University Hospital Foundation
Study officials:
affiliation: University Hospital Campus Biomedico of Rome
name: Giuseppe Pascarella, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Pascarella G, Costa F, Del Buono R, Pulitano R, Strumia A, Piliego C, De Quattro E, Cataldo R, Agro FE, Carassiti M; collaborators. Impact of the pericapsular nerve group (PENG) block on postoperative analgesia and functional recovery following total hip arthroplasty: a randomised, observer-masked, controlled trial. Anaesthesia. 2021 Nov;76(11):1492-1498. doi: 10.1111/anae.15536. Epub 2021 Jul 1.
citation: Aliste J, Layera S, Bravo D, Jara A, Munoz G, Barrientos C, Wulf R, Branez J, Finlayson RJ, Tran Q. Randomized comparison between pericapsular nerve group (PENG) block and suprainguinal fascia iliaca block for total hip arthroplasty. Reg Anesth Pain Med. 2021 Oct;46(10):874-878. doi: 10.1136/rapm-2021-102997. Epub 2021 Jul 20.
citation: Giron-Arango L, Peng PWH, Chin KJ, Brull R, Perlas A. Pericapsular Nerve Group (PENG) Block for Hip Fracture. Reg Anesth Pain Med. 2018 Nov;43(8):859-863. doi: 10.1097/AAP.0000000000000847.
citation: Del Buono R, Padua E, Pascarella G, Costa F, Tognu A, Terranova G, Greco F, Fajardo Perez M, Barbara E. Pericapsular nerve group block: an overview. Minerva Anestesiol. 2021 Apr;87(4):458-466. doi: 10.23736/S0375-9393.20.14798-9. Epub 2021 Jan 12.