Clinical trial NCT05815888: Evaluation of Perioperative Lung Ultrasound Scores (LUS) in Living Donor Nephrectomy Surgeries
Official title: Evaluation of Perioperative Lung Ultrasound Scores (LUS) in Living Donor Nephrectomy Surgeries: A Prospective Observational Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Atelectasis, Postoperative
Pulmonary Complication
Lead sponsor: Istanbul University
Sponsor class: OTHER
First posted: 2023-04-18
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult living donor nephrectomy patients who are scheduled for laparascopic nephrectomy

Brief summary: Living donor nephrectomy surgeries can be performed in lateral position with laparoscopic technique which necessitates pneumoperitoneum. Considering the position and the pneumoperitoneum, lungs can be affected macroscopically. In this study, it is aimed to observe whether lungs are affected by the aforementioned entities. The hypothesis is based on possible deterioration of the lungs due to the physical features of laparoscopic nephrectomy. Lung Ultrasound Score (LUS) will be used to evaluate the actual condition of lungs. Accordingly, one hemithorax is consisted of 6 different zones, and depending on the existence of vertical B lines (that refers to atelectasis and consolidation) each zone is scored 0 to 3. Higher scores reflect worse lung conditions that is associated with the severity of atelectasis. The LUS will be performed at three time points that are 5 minutes after intubation (T1), at the end of surgery and before extubation (T2), and at 30th minute in the postanesthesia care unit (T3). Primary outcome will be the difference between T1 and T3, secondary outcomes will include perioperative blood gas analyses, intraoperative mechanic ventilator parameters, intraoperative total amount of fluid given, postoperative pulmonary complications.


Eligibility criteria: Inclusion Criteria:

* \>18 years of age
* Kidney donors
* Nephrectomy for transplantation
* Laparoscopic surgery

Exclusion Criteria:

* Chronic obstructive pulmonary disease grade III-IV
* existing structural lung disease (eg. interstitial lung disease)
* Pulmonary hypertension (\>25 mmHg)

Primary outcomes:
measure: The comparison of T1LUS (After intubation lung ultrasound score) T2LUS (Preextubation Lung ultrasound score)
timeFrame: Up to 6 hours
Secondary outcomes:
measure: Postoperative pulmonary complications
timeFrame: Up to Postoperative 7 days.
measure: Comparison of Postanesthesia care unit (PACU) Partial arterial oxygen pressure (PaO2) and Lung ultrasound score at 30 minutes after extubation
timeFrame: Up to 6 hours
measure: Comparison of Postanesthesia care unit (PACU) Partial arterial carbon dioxide pressure (PaCO2) and Lung ultrasound score at 30 minutes after extubation
timeFrame: Up to 6 hours
measure: Comparison of total given fluid amount (milliliters) and preextubation lung ultrasound score (T2LUS)
timeFrame: Up to 6 hours
measure: Comparison of Lung ultrasound scores (LUS) after intubation(T1) and 30th minute after (T3) extubation
timeFrame: Up to postoperative 1 hour
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Istanbul University Istanbul Faculty of Medicine
Study officials:
References: