Clinical trial NCT06828705: Establish the First International Database on Semi-quantitative Values Obtained in Scintigraphy With Datscan® in Cadmium-Zinc-Telluride Camera
Official title: Establish the First International Database on Semi-quantitative Values Obtained in Scintigraphy With Datscan® in Cadmium-Zinc-Telluride (CZT) Camera (VERITON-CT)
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Neurodegenerative Diseases
Lead sponsor: Central Hospital, Nancy, France
Sponsor class: OTHER
First posted: 2025-02-14
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Maximum age (years): 99
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Adult patients who have undergone a Datscan® scintigraphy on the VERITON-CT camera in the nuclear medicine department of the Nancy University Hospital and who have an established clinical diagnosis, in the absence of neurodegenerative pathology or Parkinson's disease or Lewy body disease

Brief summary: Datscan scintigraphy is a nuclear medicine examination allowing the diagnosis of neurodegenerative pathologies linked to damage to dopaminergic pathways, such as Parkinson's disease (essential for the differential diagnosis of essential tremor).

Detailed description: Datscan scintigraphy is a nuclear medicine examination allowing the diagnosis of neurodegenerative pathologies linked to damage to dopaminergic pathways, such as Parkinson's disease (essential for the differential diagnosis of essential tremor).

There are several types of cameras allowing its performance:

* Conventional Anger cameras and,
* CZT (Cadmium-Zinc-Telluride) semiconductor cameras. At the Nancy University Hospital, the nuclear medicine department has a wide-field Cadmium-Zinc-Telluride camera: VERITON-CT (Spectrum Dynamics). The interpretation of this examination is purely visual.

The objectives are therefore to:

* Create the first international database of semi-quantitative values in 3D scintigraphy with Datscan performed with a VERITON-CT camera.
* Compare this database with another database from a conventional Anger camera (Lyon Nuclear Medicine Department) to show its superiority.

Eligibility criteria: Inclusion Criteria:

* Adult patients who have undergone a Datscan scintigraphy on the VERITON camera in the nuclear medicine department of the Nancy University Hospital and who have an established clinical diagnosis, -Absence of neurodegenerative pathology or Parkinson's disease or Lewy body disease.
* The clinical diagnosis can only be established after two years of clinical follow-up.

Exclusion Criteria:

* Excluded from this research will be the patients opposed to the use of their data, minors, atypical Parkinsonian syndromes,
* patients who died before two years of clinical follow-up,
* patients who had their Datscan examination carried out on a camera other than the VERITON and - patients lost to follow-up.

Primary outcomes:
measure: To create the first international database of Datscan by camera VERITON-CT.
timeFrame: One day
Secondary outcomes:
measure: Compare this database with another database from another type of camera (Lyon nuclear medicine team) to show its superiority.
timeFrame: One day
Other outcomes:
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Study officials:
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