Clinical trial NCT01809561: Telomeres Evaluation in Endometriosis
Official title: Telomeres Evaluation in Endometriosis
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Endometriosis
Keywords: endometriosis
telomere
telomerase
Lead sponsor: Meir Medical Center
Sponsor class: OTHER
First posted: 2013-03-12
Enrollment: 30
Sex: FEMALE
Minimum age (years): 15
Maximum age (years): 60
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: women facing surgical treatment

Brief summary: The purpose of the study is to assess the telomere array of different endometriosis tissue and endometrium from women with endometriosis compared to healthy women.

Our hypothesis is that telomere shortening and high telomerase activity will be found in tissues from women with endometriosis.

Detailed description: The purpose of the study is to assess the telomere array of different endometriosis tissue and endometrium from women with endometriosis compared to healthy women. Our hypothesis is that telomere shortening and high telomerase activity will be found in tissues from women with endometriosis, compared to women without endometriosis.

A prospective study that compares telomeres and telomerase levels in different lesions of endometriosis and endometrial tissue of women with endometriosis and healthy women without endometriosis. The study group will consist of women with suspected endometriosis facing surgical treatment and the control group will consist of healthy women facing gynecologic surgery for different indication.

We will sample endometrial tissue in both groups. In the study group we additionally will sample endometriosis lesion.

The samples collected will test for histological diagnosis of endometriosis and verification tests will be done to characterize the telomeres array and telomerase levels and other characteristics for genomic instability such as spontaneous aneuploidy.

expect telomere shortening and high telomerase activity in endometrial tissue and in endometriosis tissue sample, that won't characterize samples from women without endometriosis.

Eligibility criteria: Inclusion Criteria:

* women with suspected endometriosis facing surgical treatment

Exclusion Criteria:

* no endometriosis on histology
* malignant finding on histology

Primary outcomes:
measure: characterize the telomeres array and telomerase levels and other characteristics for genomic instability such as spontaneous aneuploidy in endometriosis tissue.
timeFrame: the tissue sample will colect at time of surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Kfar-Saba
country: Israel
facility: OBGYN department, Meir Medical Center
Study officials:
affiliation: MeirMc, Israel
name: Ron Schonman, DR
role: STUDY_CHAIR
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