louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00002283: A Comparison of Dapsone and Trimethoprim-Sulfamethoxazole in the Treatment of Pneumocystis Carinii Pneumonia (PCP) in Patients With AIDS
Official title: Randomized Prospective Study of Dapsone Versus Trimethoprim-Sulfamethoxazole in the Treatment of First Episode Pneumocystis Carinii Pneumonia in AIDS Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pneumonia, Pneumocystis Carinii
HIV Infections
Keywords: Trimethoprim-Sulfamethoxazole Combination
AIDS-Related Opportunistic Infections
Pneumonia, Pneumocystis carinii
Dapsone
Acquired Immunodeficiency Syndrome
Lead sponsor: NIH AIDS Clinical Trials Information Service
Sponsor class: INDUSTRY
First posted: 2001-08-31
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Primary purpose: TREATMENT

Brief summary: Evaluate the effectiveness rate of dapsone plus trimethoprim as a therapy for the first episode of Pneumocystis carinii pneumonia (PCP) in AIDS patients. Compare the rates and severity of adverse effects using dapsone versus trimethoprim - sulfamethoxazole (TMP / PurposeX). Establish relative toxicities with regard to suitability for outpatient treatment.


Eligibility criteria: Exclusion Criteria

Concurrent Medication:

Excluded:

* Requirement for other medications found to be effective in the treatment of Pneumocystis carinii pneumonia (PCP) (i.e., DFMO, pyrimethamine, and sulfadiazine).

Patients with the following are excluded:

* History of allergic reaction to dapsone.
* Requirement for other medications found to be effective in the treatment of Pneumocystis carinii pneumonia (PCP) (i.e., DFMO, pyrimethamine, and sulfadiazine).
* Patients subsequently found to be glucose-6-phosphate dehydrogenase (G6PD) positive will be withdrawn from the study and treated with another regimen.

Prior Medication:

Excluded:

* Requirement for other medications found to be effective in the treatment of Pneumocystis carinii pneumonia (PCP) (i.e., DFMO, pyrimethamine, and sulfadiazine).

Patients who are glucose-6-phosphate dehydrogenase (G6PD) positive will be withdrawn from the study and treated with another regimen.

Hospitalized patients with first episode of Pneumocystis carinii pneumonia (PCP) documented by GIEMSA or methenamine stain.

* Patients must:
* Be willing and able to give informed consent.
* Be expected to survive 1 week without therapy.
* Have less than 48 hours of treatment for Pneumocystis carinii pneumonia (PCP) for this episode.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Princeton
country: United States
facility: Jacobus Pharmaceutical Co
state: New Jersey
Study officials:
References:
Clinical trial NCT03439683: KAP Asynchrony Survey
Official title: Knowledge, Attitudes And Practices Among Critical Care Professionals Towards Patient-Ventilator Asynchrony
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Respiratory Insufficiency
Ventilation Therapy; Complications
Ventilators, Mechanical
Respiration, Artificial
Lead sponsor: University of Sao Paulo General Hospital
Sponsor class: OTHER
First posted: 2018-02-20
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: health professionals working in the ICU of participating hospitals, involved with patient care.

Brief summary: The investigators developed a web-based survey to assess knowledge, attitudes and practice of health care professionals about patient-ventilator asynchrony.

Detailed description: The investigators developed a survey, consisting of 25 multiple choice questions, and including snapshots of mechanical ventilator waveforms to assess the knowledge, attitudes and practice of physicians, nurses and respiratory therapists working in the ICU and caring for patients under mechanical ventilator about patient-ventilator asynchrony. The survey is web-based and will be sent for health professionals working in the ICU of the participating centers. All data will be treated anonymously with the intent of identifying knowledge gaps and inadequate practice that could be remediated by continuous medical education initiatives

Eligibility criteria: Inclusion Criteria:

* current working in the ICU as a physician, nurse or respiratory therapist

Exclusion Criteria:

* refusal to sign informed consent
* incomplete survey (less than 80% of the questions answered)

Primary outcomes:
measure: Survey score
timeFrame: in 30 minutes (at survey completion)
Secondary outcomes:
measure: attitudes score
timeFrame: in 30 minutes (at survey completion)
measure: Practice score
timeFrame: in 30 minutes (at survey completion)
Other outcomes:
Locations:
city: Sao Paulo
country: Brazil
facility: Hospital das Clínicas -HCFMUSP
state: SP
Study officials:
affiliation: University of Sao Paulo
name: Juliana C Ferreira, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06788483: Self-regulated Flipped Classroom Strategy
Official title: The Effects of Self-regulated Flipped Classroom Strategy on Nursing Students' Self-regulated Learning Abilities, Self-efficacy and Nursing Skill Performance: a Randomized Controlled Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Self-regulated Flipped Classroom Strategy
Self-Efficacy
Lead sponsor: National Defense Medical Center, Taiwan
Sponsor class: OTHER
First posted: 2025-01-23
Enrollment: 110
Sex: ALL
Minimum age (years): 18
Maximum age (years): 19
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: To examine the effect of a self-regulated flipped classroom strategy on nursing students' self-regulation abilities and self-efficacy.


Eligibility criteria: Inclusion Criteria:

* (1) second-year undergraduate nursing students (2) students taking the Adult Nursing course this semesterand (3) willingness to participate in the study.

Exclusion Criteria:

* (1) having to quit school.

Primary outcomes:
measure: self-regulated learning
timeFrame: 4 months
Secondary outcomes:
measure: self-efficacy
timeFrame: 4 months
Other outcomes:
Locations:
city: Chiayi County
country: Taiwan
facility: Ting-Yu, Chen
state: Puzi City
Study officials:
References:
Clinical trial NCT01056783: Proof of Concept Study of OC000459 in Eosinophilic Esophagitis
Official title: A Randomized, Placebo-controlled, Double-blind, Single-centre Proof-of-concept Study of OC000459 in Adult Patients With Active Eosinophilic Esophagitis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Eosinophilic Esophagitis
Keywords: EoE
Lead sponsor: Oxagen Ltd
Sponsor class: INDUSTRY
First posted: 2010-01-26
Enrollment: 26
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This will be a randomised, double blind, placebo controlled, parallel group evaluation of the effect of OC000459 given orally for eight weeks on active eosinophilic esophagitis.


Eligibility criteria: Inclusion Criteria:

* Previously diagnosed and symptomatic isolated eosinophilic esophagitis.
* Relevant eosinophil tissue inflammation as demonstrated by a mean eosinophil load \>= 20 eos/hpf in 8 biopsies at the baseline visit.
* Able to swallow placebo medication successfully under supervision in the clinic
* Free of all medications for EoE (including topical steroids) for at least 2 weeks prior to baseline and free of systemic steroids for at least 90 days before screening. A proton-pump inhibitor is allowed if required for treatment of secondary acid reflux.

Exclusion Criteria:

* Other causes of esophagitis (GERD, peptic ulceration, infection etc.)
* Other causes of eosphagaeal or generalized eosinophilia (i.e. hypereosinophilic syndromes, parasitic infection, GERD)
* The patient's EoE is dependant on the level of seasonal allergens and the patient's participation in the study will occur during the allergy season.
* History of abnormal gastric or duodenal eosinophilia (e.g. HES, Churg Strauss vasculitis, EG or a parasitic infection)
* Receipt of forbidden prescribed or over the counter medication within the 4 weeks prior to the baseline visit and for the duration of the trial, including vitamins and herbal remedies.

Primary outcomes:
measure: Effect of OC000459 on eosinophil load of the esophageal tissue
timeFrame: 8 weeks
Secondary outcomes:
measure: Effect of OC000459 on clinical manifestations of EoE
timeFrame: 8 weeks
measure: Effect of OC000459 on endoscopic alterations
timeFrame: 8 weeks
measure: Effect of OC000459 on EoE related blood and tissue biomarkers
timeFrame: 8 weeks
measure: Safety and tolerability of OC000459 in patients with active EoE
timeFrame: 8 weeks
Other outcomes:
Locations:
city: Olten
country: Switzerland
facility: Swiss EoE Research Group
Study officials:
affiliation: Swiss EoE Research Group
name: Alex Straumann, Dr
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05030883: The Effect of a Protective Message on Critical Evaluation of Fake News
Official title: The Effect of Source Type and Protective Message on the Critical Evaluation of News Messages on Facebook: An Experimental Study in the Netherlands.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Disclosure of Protective Message
Lead sponsor: Tilburg University
Sponsor class: OTHER
First posted: 2021-09-01
Enrollment: 400
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: TREATMENT

Brief summary: Background: Disinformation has become an increasing societal concern, especially due to the speed that news is shared in the current digital era. In particular in the healthcare sector disinformation can lead to serious casualties, as the current COVID-19 crisis clearly shows.

Objective: The main aim of this study was to experimentally examine the effects of information about the source's and a displayed protective warning message on users' critical evaluation of news items, as well as the perception of accuracy of the news item.

Methods: A 3(unreliable versus reliable versus no identified source) x 2 (protective message: with versus without) between subject design has been conducted among 307 participants (mean age = 29 years, SD = 10.9 years).


Eligibility criteria: Inclusion Criteria:

* Facebook user
* older than 18
* Dutch

Exclusion Criteria:

* younger than 18 years
* no facebook

Primary outcomes:
measure: Critical evaluation of source and news
timeFrame: immediately after exposure, 5 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Tilburg
country: Netherlands
facility: Tilburg School of Humanities and Digital Sciences
Study officials:
References:
citation: Folkvord F, Snelting F, Anschutz D, Hartmann T, Theben A, Gunderson L, Vermeulen I, Lupianez-Villanueva F. Effect of Source Type and Protective Message on the Critical Evaluation of News Messages on Facebook: Randomized Controlled Trial in the Netherlands. J Med Internet Res. 2022 Mar 31;24(3):e27945. doi: 10.2196/27945.
Clinical trial NCT00291083: Protocol for Postmenopausal Women at Increased Risk of Developing Breast Cancer
Official title: Study of Manual Nipple Fluid Aspiration IN Post-Menopausal Women
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Breast Cancer
Keywords: NAF
nipple aspirate fluid
breast atypia
high risk for breast cancer
breast epithelial hyperplasia
Ki-67
hormones plus chemoprevention
chemoprevention
Lead sponsor: University of Kansas Medical Center
Sponsor class: OTHER
First posted: 2006-02-13
Enrollment: 229
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Medical center

Brief summary: To examine nipple aspirate fluid for secretions that may be identified as a high risk indicator for development of breast cancer, and compare those to serum analysis.

Detailed description: To examine nipple aspirate fluid analysis in lactating women for local concentration of estrogen, prolactin, glucocorticoids, insulin, parity, prior lactation and age. NAF secretors have been reported to have modest increase in breast cancer risk compared to non-secretors . Estrogen levels have been found to be markedly higher in NAF samples than in the serum collected from the same women. Estradiol and estrone concentrations in premenopausal women are 10x and 20x greater in NAF samples than in serum and 50x and 35x greater in post-menopausal women not on HRT. It has been suggested that the disparity between serum and NAF levels may be due to local estrogen production via aromatase and sulfatase.

Eligibility criteria: Inclusion Criteria:

* women with high a high risk of breast cancer
* Older than 18

Exclusion Criteria:

* anticoagulants
* marked breast tenderness
* pregnant or within twelve months of breast feeding/childbirth

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Kansas City
country: United States
facility: University of Kansas Medical Center
state: Kansas
Study officials:
affiliation: University of Kansas Medical Center
name: Carol J Fabian, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01830283: The Safety, Immunogenicity and Immune Effect Research of the Varicella Vaccine After the 2nd Dose Vaccination
Official title: Phase 4 Study of the Varicella Vaccine After the 2nd Dose Vaccination
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Varicella
Lead sponsor: Beijing Center for Disease Control and Prevention
Sponsor class: OTHER_GOV
First posted: 2013-04-12
Enrollment: 50000
Sex: ALL
Minimum age (years): 4
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: To investigate the safety, immunogenicity and immune effect of the Varicella vaccine after the 2nd dose vaccination in Chao yang district, Bei jing, since the 2nd varicella vaccination was promoted by Beijing Center for Disease Control and Prevention in November, 2012.

Detailed description: "Breakthrough" varicella cases and varicella cases were monitored to evaluate the protective effective in a large population.

Make the basic evaluation of safety for the two dose of varicella vaccination

Monitoring the Varicella virus origin and virus types from illness cases in Chao yang district

Make the evaluation of healthy costs reduce for the varicella emergency vaccination after large number of varicella cases occurred.

Eligibility criteria: Inclusion Criteria:

* Participants were between 4-12 years old
* Participants were in good healthy determined through medical history, physical examination, clinical judgment of the investor

Exclusion Criteria:

* Having a fever (axillary temperature \>37.0℃) before enrollment;
* Having a disease history of seizures, brain and mental disease and the vaccination history of allergies and convulsions;
* Antibiotics allergy;
* Having a problem of intramuscular injection because thrombocytopenia or other blood coagulation disorder;
* Having immunodeficiency or under immunosuppression therapy, radiation therapy;
* Having respiratory diseases, acute infection, chronic disease and HIV infection;
* Having systemic skin rash, skin tinea, herpes;
* Chronic liver and kidney disease;
* Heart disease, and severe hypertension;
* Have received whole blood, plasma or immunoglobulin therapy 3 months before enrollment;
* Have not received other vaccination in 7 days before enrollment

Primary outcomes:
measure: Incidence of varicella after 2 dose vaccination
timeFrame: 5 years
Secondary outcomes:
measure: Adverse event rate of varicella vaccine after 2 dose injection
timeFrame: 5 years
Other outcomes:
measure: Antibody titre of varicella vaccine after 2 dose injection
timeFrame: 6 monthes
Locations:
city: Beijing
country: China
facility: Beijing Chaoyang District Centers for Disease Control and Prevention
Study officials:
affiliation: Beijing Chaoyang District Centers for Disease Control and Prevention
name: Nianmin Shi
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04175483: The Evaluation of Airway Dimension by Using Ultrasonography
Official title: The Evaluation of Airway Dimension by Using Ultrasonography
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Subglottic Airway Diameter in Normal Adults
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2019-11-25
Enrollment: 120
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult healthy volunteers (aged more than 20 years) without pre-existing airway or respiratory diseases, neck tumors and a history of neck operation.

Brief summary: The aim of this study is to measure the dimension of airway in healthy Asian population. We recruit normal volunteer subjects aged more than 20 years old. Subglottic transverse diameter is measured and recorded by ultrasonography.

Detailed description: The aim of this study is to measure the dimension of airway in healthy Asian population. We recruit normal volunteer subjects aged more than 20 years old. Subglottic transverse diameter is measured and recorded by ultrasonography.

Eligibility criteria: Inclusion Criteria:

* Adult healthy volunteers (aged more than 20 years) without pre-existing airway or respiratory diseases, neck tumors and a history of neck operation.

Exclusion Criteria:

* pre-existing airway or respiratory diseases, neck tumors and a history of neck operation.

Primary outcomes:
measure: transverse glottic diameter by ultrasonography
timeFrame: one day
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: Wan-Ching Lien
Study officials:
References:
Clinical trial NCT01758783: Therapy of Radiation Enteritis With Glutamine
Official title: the Efficacy of Glutamine in the Therapy of Radiation Enteritis Among Patients Treated With Radiation of Abdomen and Pelvis.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Radiation Enteritis
Lead sponsor: Nanjing University School of Medicine
Sponsor class: OTHER
First posted: 2013-01-01
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Objective: To evaluate the effects of perioperative glutamine supplemented total parenteral nutrition support on nutritional status, immunologic function and intestinal permeability of patients with chronic radiation intestinal injury.

Methods: The 40 patients with CRII were randomized into two groups, the standard TPN group and glutamine-enriched TPN group. The patients were administered total parenteral nutrition for at least four weeks (two weeks pre-operation and two weeks post-operation). The nutritional status, immunologic function, plasma concentration of glutamine and intestinal permeability were measured at 1 day, 1 week and 2 weeks pre-operation, 3 day, 1 week and 2 weeks post-operation. Nutrition status was determined the plasma concentrations of hemoglobin, albumin, prealbumin, transferrin and triglyceride. Immunologic function were measured by the percentages of CD4+T cells and CD8+T cells, the ratio of CD4 +T cells to CD8+T cells ( CD4 +/CD8 +) was calculated， and serum IgA, IgM and IgG．The intestinal permeability was detected by the urinal ratio of lactulose and mannitol.


Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of chronic radiation enteritis
* Need the operation
* Malnutrition

Exclusion Criteria:

* Hepatic failure
* Kidney failure
* Neoplasm recurrence
* Serious cardiovascular/metabolic disease
* Pregnancy and lactation

Primary outcomes:
measure: inflammatory factor
timeFrame: 2 weeks after the surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Nanjing
country: China
facility: Department of Surgery, Nanjing General Hospital of Nanjing Command
state: Jiangsu
Study officials:
References:
Clinical trial NCT01438983: Oral Candida in Infants and Dietary Type
Official title: Evaluation the Effect of Dietary Type on Oral Candida Carriage in Infants
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Oral Candida
Breastfeeding
Bottle Feeding
Lead sponsor: Shahid Sadoughi University of Medical Sciences and Health Services
Sponsor class: OTHER
First posted: 2011-09-22
Enrollment: 90
Sex: ALL
Minimum age (years): 1
Maximum age (years): 24
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The investigators evaluated 90 infants in 1-24 months (45 breastfeeding and 45 bottle feeding infants) who attended to Yazd nikoopur clinic for regular pediatric appointment.

Brief summary: This is an observational, non-randomised trial to evaluate the effect of dietary type on infants oral candida colonization the investigators evaluated 90 infants in 1-24 months (45 breastfeeding and 45 bottle feeding infants) who attended to Yazd clinic for regular pediatric appointment. Infants with unremarkable health histories, normal weight, free of sign or symptom of oral candidiasis or other mucosal disease. Their mothers were also healthy and without sign or symptom of vagina or mammary candidiasis. Pacifier usage, use of antibiotics in last months, sign or symptom of oral candidiasis in infants or vagina and mammary candidiasis in mothers were exclusion criteria.

Detailed description: After filling in a questionnaire about infants dietary intake, age and sex and their mothers education level and health condition, a pre-moistened sterile cotton swab was taken from dorsal surface of tongue and mid-plate. The swabs were cultured in agar plate containing sabourauds dextrose agar medium with chloramphenicol, and kept in 37 C for 48 hours. The number of candida colonies was counted and germ tube test performed to separate candida albicans from other types. The data was collected and analyzed by SPSS software and chi-square, logistic regression and mann-whitney test. Study hypothesis: feeding by mothers milk reduces oral candida colonization.

Eligibility criteria: Inclusion Criteria:

* healthy infants
* healthy mothers

Exclusion Criteria:

* pacifier usage
* use of antibiotics in last month
* sign or symptom of oral candidiasis in infants
* vagina and mammary candidiasis in mothers

Primary outcomes:
measure: mean number of candida colonies
timeFrame: 6 months
Secondary outcomes:
measure: prevalence of oral candida colonization in infants according to age and sex
timeFrame: 6 months
Other outcomes:
Locations:
city: Yazd
country: Iran, Islamic Republic of
facility: Nastaran Azimi
Study officials:
affiliation: shahid sadoughi university of medical sciences and health science
name: nastaran azimi, dr
role: PRINCIPAL_INVESTIGATOR
References: