Clinical trial NCT05472636: Evaluation of 41 Cases of Pediatric Granuloma Annulare
Official title: Clinical and Histopathological Evaluation of 41 Cases of Pediatric Granuloma Annulare
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Granuloma Annulare
Keywords: Granuloma Annulare
Pediatric Dermatology
Pediatric Granuloma Annulare
Lead sponsor: Istanbul Training and Research Hospital
Sponsor class: OTHER_GOV
First posted: 2022-07-25
Enrollment: 41
Sex: ALL
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients under the age of 18 who were admitted to the dermatology outpatient clinic between 2008-2021 and diagnosed with granuloma annulare

Brief summary: INTRODUCTION: Granuloma annulare is a non-infectious, granulomatous disease that can affect children and adults. Although there are many studies examining adult patients, there are limited studies examining pediatric granuloma annulare cases. It is aimed to examine the demographic, clinical, and pathological features of pediatric granuloma annulare cases in this study.

MATERIALS and METHODS: This study was performed retrospectively in a single-center, tertiary dermatology hospital. Forty-one patients, under the age of 18 who were admitted to the dermatology outpatient clinic between 2008-2021 and diagnosed with granuloma annulare were scanned from the hospital database and patient photograph archive. Demographic characteristics, and clinical and histopathological features were evaluated.

Detailed description: Granuloma annulare; is a non-infectious, granulomatous skin reaction with potential triggers that can affect the adult and pediatric age group. Diabetes mellitus, hyperlipidemia, and malignancy have been described in association with adult granuloma annulare cases. While there are studies on the clinical, pathological features and associated diseases in patients with adult granuloma annulare, a limited number of studies have been conducted on pediatric granuloma annulare patients. Therefore, clinical and histopathological evaluation of pediatric granuloma annulare cases was planned in our study.

This study was performed retrospectively in a single-center tertiary dermatology hospital. Patients under the age of 18 who were admitted to the dermatology outpatient clinic between 2008-2021 and diagnosed with granuloma annulare were scanned from the hospital database and patient photograph archive. Cases with uncertain diagnosis were not included in the study. Cases with dermatological findings recorded in detail and/or diagnosed histopathologically were included in the study. Demographic features, lesion localization, lesion characteristics (size, elementary lesion, color), involvement (localized/generalized), histopathological features, concomitant diseases, differential diagnoses in cases with histopathology, regression time and recommended treatments were recorded.

Eligibility criteria: Inclusion Criteria:

* Being under 18 years old
* Having granuloma annulare
* Applying to the Istanbul Training and Research Hospital, Dermatology Outpatient Clinic between 2008-2021
* Consenting to participate in the study

Exclusion Criteria:

-Being over 18 years old

Primary outcomes:
measure: Evaluation of the genders of the pediatric patients with granuloma annulare
timeFrame: day 0
measure: Evaluation of the ages of the pediatric patients with granuloma annulare
timeFrame: day 0
measure: Evaluation of the concomitant diseases of the pediatric patients with granuloma annulare
timeFrame: day 0
measure: Evaluation of the lesion localization of the pediatric patients with granuloma annulare
timeFrame: day 0
measure: Evaluation of the lesion duration of the pediatric patients with granuloma annulare
timeFrame: day 0
measure: Evaluation of the lesion type of the pediatric patients with granuloma annulare
timeFrame: day 0
measure: Evaluation of the mean size of the lesion
timeFrame: day 0
measure: Evaluation of the clinical involvement
timeFrame: day 0
measure: Histopathological evaluation of the infiltration type of the pediatric patients with granuloma annulare
timeFrame: day 0
measure: Histopathological evaluation of the infiltration pattern of the pediatric patients with granuloma annulare
timeFrame: day 0
measure: Evaluation of epidermal findings
timeFrame: day 0
measure: Evaluation of depth of infiltrate
timeFrame: day 0
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Istanbul Training and Research Hospital
Study officials:
References: