Clinical trial NCT02840305: Brain Bases of Natural Scenes's Visual Perception of Natural Scenes
Official title: Brain Bases of Visual Perceptionnatural Scenes of Natural Scenes.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy Volunteer
Keywords: Natural scenes
Brain bases
Visual perception
MRI
Lead sponsor: University Hospital, Grenoble
Sponsor class: OTHER
First posted: 2016-07-21
Enrollment: 141
Sex: ALL
Minimum age (years): 4
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL

Brief summary: Using the available data from psychophysics, cellular electrophysiology and functionnal neuroanatomy of visual pathway, current models of visual recognition suppose that the perception of scenes start with a parallel extraction of differents elementary visual characteristics to different spatial frequencies according to a default processing principle named : 'coarse-to-fine'.

According to this principle, the visual scene's analysis would be decomposed in two steps. Fisrt, the fast analysis of the global information borne by low frequency of the scene will provide an overview of the scene's structure and would enable a first perceptive categorisation which would be then refined, approved or denied by the latest analysis of the most local, detailed and precise information, carried by the very high spatial frequency of the scene.

The research carried out since several years is preparing a biologically plausible model and to find brain bases by different imaging techniques among healthy subjects but also patients with a brain lesion and patients with a peripheral lesion.

The main goal of this Magnetic Resonance Imaging study is to find brain bases of natural scenes's visual perception of the natural scenes.

Three studies in Magnetic Resonance Imaging will be conducted, during which subjects will have to categorize pictures of natural scenes filtered in spatial frequencies. The outcome of this study will allow to refine models of visual recognition, most of them based on analysis of spatial frequencies.


Eligibility criteria: Inclusion Criteria for young adults :

* Subjet over 18 years and less than 30 years
* Affiliation to a social security
* Free signed consent
* Medical exam done before participation to the study
* Normal or corrected visual acuity

Exclusion Criteria four young adults :

* Counter-argument to MRI
* Pregnant, breast-feeding or parturient women
* Adults non protected or unable to express their consent
* Adults protected
* Important earing or visual disorder
* Neuropsychiatric disorder current or past passée ou présente (exept benign epilepsy)
* Severe affection on a general level (cardiac, respiratory, hematologic, renal, hépatic, cancerous)
* Drug treatment in progress (exept anti-epileptic drug) likely to de modulate brain activity

Inclusion Criteria for old adults :

* Subjet over 50 years
* Affiliation to a social security
* Free signed consent
* Medical exam done before participation to the study
* Normal or corrected visual acuity

Exclusion Criteria four old adults :

* Counter-argument to MRI
* Pregnant, breast-feeding or parturient women
* Adults non protected or unable to express their consent
* Adults protected
* Important earing or visual disorder
* Neuropsychiatric disorder current or past passée ou présente (exept benign epilepsy)
* Severe affection on a general level (cardiac, respiratory, hematologic, renal, hépatic, cancerous)
* Drug treatment in progress (exept anti-epileptic drug) likely to de modulate brain activity

Inclusion Criteria for children :

* Children between 4 and 12 years
* Affiliation to a social security
* Free signed consent
* Medical exam done before participation to the study
* Normal or corrected visual acuity

Exclusion Criteria four children :

* Counter-argument to MRI
* Important earing or visual disorder
* Important development disorder and/or acquisitions identified by parents and/or school teachers
* Neuropsychiatric disorder current or past passée ou présente (exept benign epilepsy)
* Severe affection on a general level (cardiac, respiratory, hematologic, renal, hépatic, cancerous)
* Drug treatment in progress (exept anti-epileptic drug) likely to de modulate brain activity

Primary outcomes:
measure: Identify brain bases of natural scenes's visual perception of the natural scenes
timeFrame: About 80 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: La Tronche
country: France
facility: UniversityHospitalGrenoble
Study officials:
affiliation: Grenoble Hospital University
name: Alexandre Krainik, Professor
role: PRINCIPAL_INVESTIGATOR
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