Clinical trial NCT03351907: Cardiovascular Disease Cohort in Guangdong Province
Official title: Prospective Cohort Study of Cardiovascular Disease in Guangdong Province
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Cardiovascular Disease
Lead sponsor: Sun Yat-sen University
Sponsor class: OTHER
First posted: 2017-11-24
Enrollment: 5000
Sex: ALL
Minimum age (years): 30
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Cardiovascular disease patients (30-85 years old) who have been living in Guangdong province for more than 5 years.

Brief summary: Patients with cardiovascular diseases from Guangdong province will be recruited and followed up for at least 4 years to evaluate the risk factors for cardiovascular-related mortality and disability. Physical examination, questionnaire survey and biological sample collection will be conducted at baseline and the incidence of all-cause and cardiovascular mortality will be investigated during follow-up.

Detailed description: 5,000 patients (30-85 years old) with primary hypertension, coronary heart disease, heart failure or peripheral vascular disease and who have been living in Guangdong province for more than 5 years will be recruited. All participants will be prospectively followed up for the incidence of all-cause and cardiovascular mortality. Information about socio-demographic, diet, lifestyle, psychological status, medical history and current medication will be collected by questionnaires. Physical examinations including height, weight, waist and hip circumferences, blood pressure, fat mass and vital capacity will be conducted.Besides, blood, urine and fecal samples will be collected for further analysis. The associations between diet and lifestyle and risks for cardiovascular disease will be evaluated.

Eligibility criteria: Inclusion Criteria:

* Cardiovascular disease patients (30-85 years old) who have been living in Guangdong province for more than 5 years.
* Patients have been diagnosed with primary hypertension, coronary heart disease, heart failure or peripheral vascular disease, etc.

Exclusion Criteria:

* Patients with cardiogenic (acute pericarditis, rheumatic coronary arteritis, hypertrophic cardiomyopathy, etc.) Or non-cardiogenic chest pain.
* any subject who suffer from malignant tumors, infectious diseases, advanced liver disease, major disability and cannot participate in the study.

Primary outcomes:
measure: All-Cause Mortality
timeFrame: 4 years
Secondary outcomes:
measure: Cardiovascular Mortality
timeFrame: 4 years
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Sun Yat-Sen University
state: Guangdong
Study officials:
affiliation: School of Public Health,Nutrition and Food Hygiene,Sun Yat-sen University
name: Min Xia
role: PRINCIPAL_INVESTIGATOR
References:
citation: Li X, Lin Y, Wang S, Zhou S, Ju J, Wang X, Chen Y, Xia M. Extracellular Superoxide Dismutase Is Associated With Left Ventricular Geometry and Heart Failure in Patients With Cardiovascular Disease. J Am Heart Assoc. 2020 Aug 4;9(15):e016862. doi: 10.1161/JAHA.120.016862. Epub 2020 Jul 29.