Clinical trial NCT05989971: The Effect of Continuous Renal Replacement Therapy on the Efficiency of Extracorporeal CO2 Removal
Official title: The Effect of Continuous Renal Replacement Therapy on the Efficiency of Extracorporeal CO2 Removal
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Respiratory Failure With Hypercapnia
Lead sponsor: Southeast University, China
Sponsor class: OTHER
First posted: 2023-08-14
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: using Extracorporeal carbon dioxide removal combined with continuous renal replacement therapy

Brief summary: In the design of extracorporeal carbon dioxide removal (ECCO2R) combined with continuous renal replacement therapy (CRRT) equipment, in model of continuous veno-venous hemofiltration (CVVH) , the HCO3- concentration in the pre membrane lung blood is diluted by the replacement solution, and a decrease in HCO3- leads to a decrease in PCO2. On the other hand, in continuous veno-venous hemodialysis (CVVHD), HCO3- in post membrane blood will exchange interaction. The exchange results of HCO3- determine the impact of CVVHD on the CO2 removal efficiency of the ECCO2R combined CRRT system. This study aims to investigate the effects of CVVH and CVVHD on in vitro CO2 clearance efficiency.

Detailed description: In the design of extracorporeal carbon dioxide removal (ECCO2R) combined with continuous renal replacement therapy (CRRT) equipment, the pre dilution replacement solution for continuous veno-venous hemofiltration (CVVH) enters the extracorporeal bloodstream upstream of the membrane lung, so the HCO3- concentration in the pre membrane lung blood is diluted by the replacement solution. HCO3- and dissolved CO2 are in a dynamic and rapid equilibrium state, and a decrease in HCO3- leads to a decrease in PCO2. On the other hand, in continuous veno-venous hemodialysis (CVVHD), the blood after the membrane needs to undergo material exchange with the dialysate through a filter. The dialysate is usually HCO3- with normal plasma concentration, so HCO3- in post membrane blood will exchange interaction. The exchange results of HCO3- determine the impact of CVVHD on the CO2 removal efficiency of the ECCO2R combined CRRT system. This study aims to investigate the effects of CVVH and CVVHD on in vitro CO2 clearance efficiency.

Eligibility criteria: Inclusion Criteria:

* Using Extracorporeal carbon dioxide removal combined with continuous renal replacement therapy
* 18 years ≤ age ≤ 85 years;

Exclusion Criteria:

* Severe hemodynamic instability (increased dosage of vasoactive drugs or MAP ≤ 65mmHg within two hours);
* Severe electrolyte deficiency (including severe hyponatremia (blood sodium\<130mmol/L) and hypokalemia (blood potassium\<3.0mmol/L));
* Participate in other intervention studies within 30 days;
* Do not consent this research

Primary outcomes:
measure: extracorporeal CO2 removal rate
timeFrame: after 30min of continuous renal replacement therapy
Secondary outcomes:
Other outcomes:
Locations:
city: Nanjing
country: China
facility: Ling Liu
state: Jiangsu
Study officials:
affiliation: Zhongda Hospital
name: Ling Liu
role: STUDY_DIRECTOR
References: