Clinical trial NCT06115187: Correlation of Different Ultrasonographic Indices With Clinical Parameters in Carpal Tunnel Syndrome
Official title: Correlation of Different Ultrasonographic Indices With Clinical Parameters in Carpal Tunnel Syndrome
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Carpal Tunnel Syndrome
Keywords: Carpal tunnel syndrome
Ultrasound
Echogenicity
Lead sponsor: Sultan Abdulhamid Han Training and Research Hospital, Istanbul, Turkey
Sponsor class: OTHER
First posted: 2023-11-02
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with diagnosed CTS

Brief summary: The aim of this study is to investigate the relationship between different ultrasonographic indices used in patients with carpal tunnel syndrome and clinical parameters.

The main questions it aims to answer are:

* To what extent are the ultrasonographic parameters used in the diagnosis of carpal tunnel syndrome related to the patient's clinical complaints?
* To what extent are the different ultrasonographic parameters used in the diagnosis of carpal tunnel syndrome correlated with each other?

Detailed description: Carpal tunnel syndrome (CTS) is the most common entrapment neuropathy and the main mechanism is compression of the median nerve under the transverse ligament at the wrist level. In CTS, neuropathic complaints such as numbness, burning and tingling in the palmar face of the first two fingers, which are the innervation area of the median nerve, and fatigue in the hand are the most common symptoms. In the diagnosis of CTS, the diagnosis is made electrodiagnostically along with typical clinical findings. However, in recent years, ultrasound has become one of the most preferred methods in the diagnosis of CTS because it is non-invasive, rapid and correlates with electrodiagnostic methods. Diameter, cross-sectional area and echogenicity of the median nerve at the carpal tunnel entrance are the most frequently evaluated parameters in ultrasonographic examination. In different studies, it is aimed to increase the power of ultrasonography in the diagnosis of CTS with various indices created in addition to standardized measurements. The most commonly used ultrasonographic indices, which have been shown to be correlated with electrodiagnostic diagnostic methods, are the wrist-forearm median nerve cross-sectional area ratio, the ratio of median nerve cross-sectional area to carpal tunnel area at the carpal tunnel entry level, and echogenicity assessment. Although the relationship of these indexes, which are reported to have sufficient diagnostic sensitivity and specificity, with the patient's clinical complaints is shown on a measurement basis, there is not enough data on the comparison of different formulas and their correlation with the patient's clinical complaints, including neuropathic pain.Based on this, this study aimed to investigate the relationship between ultrasonographic indices used in patients diagnosed with CTS and clinical parameters.

Eligibility criteria: Inclusion Criteria:

* Being diagnosed with carpal tunnel syndrome based on clinical and electrodiagnostic findings
* Agreeing to participate in the study

Exclusion Criteria:

* Concomitant history of diabetes, systemic inflammatory disease, active infection and malignancy
* Having a disease with neuropathic pain such as polyneuropathy, radiculopathy,multiple sclerosis
* Not agreeing to participate in the study
* History of surgery due to CTS

Primary outcomes:
measure: median nerve ultrasound
timeFrame: 3 months
measure: median nerve ultrasound
timeFrame: 3 months
measure: median nerve ultrasound
timeFrame: 3 months
measure: median nerve ultrasound
timeFrame: 3 months
measure: median nerve ultrasound
timeFrame: 3 months
measure: median nerve ultrasound
timeFrame: 3 months
Secondary outcomes:
measure: Visual analog scale
timeFrame: 3 months
measure: Upper extremity nerve conduction studies
timeFrame: 3 months
measure: Upper extremity nerve conduction studies
timeFrame: 3 months
measure: Upper extremity nerve conduction studies
timeFrame: 3 months
measure: Upper extremity nerve conduction studies
timeFrame: 3 months
measure: Self Leeds Assessment of Neuropathic Symptoms and Sign
timeFrame: 3 months
measure: Boston Carpal Tunnel Questionnaire
timeFrame: 3 months
measure: hand grip strength
timeFrame: 3 months
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Saglik Bilimleri Universitesi
state: Uskudar
Study officials:
affiliation: Saglik Bilimleri Universitesi
name: Emre Ata, Assoc.Prof
role: STUDY_CHAIR
References: