Clinical trial NCT00223483: Identification and Analysis of Immunomodulatory Molecules in Patients With Hematologic Disorders and Healthy Volunteers
Official title: Identification and Analysis of Immunomodulatory Molecules From Leukocytes in Patients With Hematologic Disorders and Healthy Volunteers
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hematologic Diseases
Healthy Volunteers
Keywords: Hematologic Diseases
Genomics
Cytokines
Chemokines
Receptors
Lead sponsor: The University of Texas Health Science Center at San Antonio
Sponsor class: OTHER
Collaborators: name: US Department of Veterans Affairs
First posted: 2005-09-22
Enrollment: 512
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Primary care clinic and community samples

Brief summary: This research study goal is to analyze the plasma and the cells that make up part of the immune system. We want to learn how the plasma and cells work. These may influence why one person will develop an infection and another will not, or why one person develops severe symptoms of a disease while others remain without symptoms.

Detailed description: This research study goal is to analyze the plasma and the cells that make up part of the immune system. These cells, called white cells or leukocytes, are present in blood. We want to learn how these cells work to prevent infection and how they respond after an infection occurs. We also want to study certain molecules present on the plasma, on or in these cells, and the genetic material that allows these molecules to be made. These molecules may influence why one person will develop an infection and another will not, or why one person develops severe symptoms of a disease while others remain without symptoms. This study may increase our understanding of a variety of diseases including infections such as HIV, allergic diseases such as asthma, joint diseases such as rheumatoid arthritis, certain cancers, and the rejection process that sometimes occurs after transplantation of an organ.

Eligibility criteria: Inclusion Criteria:

* Must be able to give blood
* Must be able to give informed consent
* Signed, written informed consent

Exclusion Criteria:

* Individuals with a history severe anemia, inadequate venous access, severe blood or coagulation disorders.
* Pregnant women are excluded because it is a unique immunotolerant state and will alter the profile of immunomodulatory molecules.

Primary outcomes:
measure: Repository collection of plasma and serum for future analysis.
timeFrame: 12 years
Secondary outcomes:
Other outcomes:
Locations:
city: San Antonio
country: United States
facility: Department of Veterans Affairs, South Texas Veterans Health Care System, Audie L. Murphy Memorial Veterans Hospital Division
state: Texas
city: San Antonio
country: United States
facility: The University of Texas Health Science Center at San Antonio
state: Texas
Study officials:
affiliation: The University of Texas Health Science Center at San Antonio
name: Cesar O Freytes, MD
role: STUDY_DIRECTOR
References: