Clinical trial NCT05139836: A Study to Assess Disease Activity in Adolescent and Adult Participants With Atopic Dermatitis Who Receive Oral Upadacitinib Tablets in a Real-World Setting
Official title: Non-Interventional, Prospective Observational Cohort Study to Investigate the Effectiveness and Sustained Disease Control of an Upadacitinib Therapy in Moderate to Severe Atopic Dermatitis Patients Over Two Years
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Atopic Dermatitis
Keywords: Atopic Dermatitis (AD)
Upadacitinib
RINVOQ
Lead sponsor: AbbVie
Sponsor class: INDUSTRY
First posted: 2021-12-01
Enrollment: 772
Sex: ALL
Minimum age (years): 12
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adolescent and adult participants with atopic dermatitis who have been prescribed upadacitinib in the course of routine practice according to relevant approved licenses.

Brief summary: Atopic dermatitis (AD) is a skin condition that may cause a rash and itching due to inflammation of the skin. Therapies spread over the skin may not be enough to control the AD in trial participants who require systemic anti-inflammatory treatment. This study will assess the real-world effectiveness of upadacitinib on early and sustained response along adolescent and adult participants with AD. This study also aims to understand upadacitinib utilization patterns in real-world clinical practice.

Upadacitinib (RINVOQ) is approved in the EU for the treatment of moderate to severe AD in adults and adolescents 12 years and older who are candidates for systemic therapy. Approximately 772 adolescent and adult participants with AD will be enrolled at up to 200 sites in Germany.

Participants will receive oral upadacitinib tablets as prescribed by the physician prior to enrolling in this study in accordance with the terms of the local marketing authorization and professional and reimbursement guidelines with regards to dose, population, and indication. The overall duration of the study is approximately 2 years.

Participants will attend regular visits per routine clinical practice. The effect of the treatment will be checked by medical assessments, checking for side effects, and questionnaires.


Eligibility criteria: Inclusion Criteria:

* Body weight \>=30 kg at baseline for participants between \>=12 and \<18 years of age.
* Physician confirmed diagnosis of moderate to severe atopic dermatitis at the time of enrollment.
* Upadacitinib initiated as per the local label. The decision to prescribe upadacitinib must have been made prior to and independently of study participation.
* Medical and medication history available at least for the last 6 months.

Exclusion Criteria:

- Current participation in interventional research (note: this does not include non-interventional, post-marketing observational studies, or registry participation).

Primary outcomes:
measure: Percentage of Participants Achieving Disease Control Defined by Atopic Dermatitis Control Tool (ADCT) Total Score <7 Points
timeFrame: Month 3
measure: Percentage of Participants Achieving Disease Control Defined by ADCT Total Score <7 Points Among Participants Who Achieved Disease Control at Month 3
timeFrame: Month 24
Secondary outcomes:
measure: Percentage of Participants Achieving Disease Control Defined by ADCT Total Score <7 Points
timeFrame: Up to 24 Months
measure: Percentage of Participants with An ADCT Total Score Reduction >=5 from Baseline
timeFrame: Up to 24 Months
measure: Percentage of Participants Achieving Disease Control as Defined by ADCT Item 4 (Sleep Problems) <1 Point and All Other Items <2 Points
timeFrame: Up to 24 Months
measure: Percentage of Participants Achieving Disease Control as Defined by ADCT Total Score <7 Points at Month 3 and Maintaining Disease Control
timeFrame: Up to 21 Months (Excluding Month 3 - Primary Endpoint)
measure: Absolute Score for ADCT Total Score
timeFrame: Up to 24 Months
measure: Absolute Change from Baseline for ADCT Total Score
timeFrame: Up to 24 Months
measure: Time to Achieve ADCT Total Score Reduction >=5 Points from Baseline
timeFrame: Up to 24 Months
measure: Time to Achieve Disease Control as Defined by ADCT Total Score <7 Points
timeFrame: Up to 24 Months
measure: Percent Change from Baseline for ADCT Total Score
timeFrame: Up to 24 Months
measure: Percentage of Participants Achieving Eczema Area and Severity Index (EASI) 50
timeFrame: Up to 24 Months
measure: Percentage of Participants Achieving EASI 75
timeFrame: Up to 24 Months
measure: Percentage of Participants Achieving EASI 90
timeFrame: Up to 24 Months
measure: Percentage of Participants Achieving EASI 100
timeFrame: Up to 24 Months
measure: Percentage of Participants Achieving Absolute EASI <=7
timeFrame: Up to 24 Months
measure: Absolute Score for EASI
timeFrame: Up to 24 Months
measure: Absolute Change from Baseline for EASI
timeFrame: Up to 24 Months
measure: Percent Change from Baseline for EASI
timeFrame: Up to 24 Months
measure: Time to Achieve EASI 50
timeFrame: Up to 24 Months
measure: Time to Achieve EASI 75
timeFrame: Up to 24 Months
measure: Time to Achieve EASI 90
timeFrame: Up to 24 Months
measure: Time to Achieve EASI 100
timeFrame: Up to 24 Months
measure: Time to Achieve Absolute EASI <=7
timeFrame: Up to 24 Months
measure: Percentage of Participants Achieving EASI 50 in the Head and/or Neck Body Region
timeFrame: Up to 24 Months
measure: Percentage of Participants Achieving EASI 75 in the Head and/or Neck Body Region
timeFrame: Up to 24 Months
measure: Percentage of Participants Achieving EASI 90 in the Head and/or Neck Body Region
timeFrame: Up to 24 Months
measure: Percentage of Participants Achieving EASI 100 in the Head and/or Neck Body Region
timeFrame: Up to 24 Months
measure: Percentage of Participants Achieving Validated Investigator Global Assessment for Atopic Dermatitis (vIGA-AD) <=1
timeFrame: Up to 24 Months
measure: Percentage of Participants Achieving Worst Pruritus Numerical Rating Scale (WP-NRS) <=1
timeFrame: Up to 24 Months
measure: Percentage of Participants Achieving WP-NRS <=3
timeFrame: Up to 24 Months
measure: Percentage of Participants Achieving a WP-NRS Reduction >=4 from Baseline
timeFrame: Up to 24 Months
measure: Absolute Score for WP-NRS
timeFrame: Up to 24 Months
measure: Absolute Change from Baseline for WP-NRS
timeFrame: Up to 24 Months
measure: Percent Change from Baseline for WP-NRS
timeFrame: Up to 24 Months
measure: Time to Achieve WP-NRS <=1
timeFrame: Up to 24 Months
measure: Absolute Change from Baseline for SCORAD Sleep VAS
timeFrame: Up to 24 Months
measure: Absolute Score for Score Atopic Dermatitis (SCORAD) Sleep Visual Analog Scale (VAS)
timeFrame: Up to 24 Months
measure: Percent Change from Baseline for SCORAD Sleep VAS
timeFrame: Up to 24 Months
measure: Percentage of Participants Achieving Dermatology Life Quality Index (DLQI)/Children's Dermatology Life Quality Index (cDLQI) <=1
timeFrame: Up to 24 Months
measure: Percentage of Participants Achieving DLQI/cDLQI <=5
timeFrame: Up to 24 Months
measure: Percentage of Participants Achieving DLQI/cDLQI Reduction >=4 from Baseline
timeFrame: Up to 24 Months
measure: Absolute Score for DLQI/cDLQI
timeFrame: Up to 24 Months
measure: Absolute Change from Baseline for DLQI/cDLQI
timeFrame: Up to 24 Months
measure: Percent Change from Baseline for DLQI/cDLQI
timeFrame: Up to 24 Months
measure: Time to Achieve DLQI/cDLQI <=1
timeFrame: Up to 24 Months
measure: Absolute Score for Hospital Anxiety and Depression Scale for Anxiety (HADS-A)
timeFrame: Up to 24 Months
measure: Absolute Change from Baseline for HADS-A
timeFrame: Up to 24 Months
measure: Percent Change from Baseline for HADS-A
timeFrame: Up to 24 Months
measure: Absolute Score for Hospital Anxiety and Depression Scale for Depression (HADS-D)
timeFrame: Up to 24 Months
measure: Absolute Change from Baseline for HADS-D
timeFrame: Up to 24 Months
measure: Percent Change from Baseline for HADS-D
timeFrame: Up to 24 Months
measure: Absolute Score for Stigmatization (6-Item Stigmatization Scale)
timeFrame: Up to 24 Months
measure: Absolute Change from Baseline for Stigmatization (6-Item Stigmatization Scale)
timeFrame: Up to 24 Months
measure: Percent Change from Baseline for Stigmatization (6-Item Stigmatization Scale)
timeFrame: Up to 24 Months
measure: Absolute Score for Asthma Control Test (ACT) in Participants Having a Confirmed Diagnosis of Asthma at Baseline
timeFrame: Up to 24 Months
measure: Absolute Change from Baseline in ACT in Participants Having a Confirmed Diagnosis of Asthma at Baseline
timeFrame: Up to 24 Months
measure: Percent Change from Baseline in ACT in Participants Having a Confirmed Diagnosis of Asthma at Baseline
timeFrame: Up to 24 Months
measure: Percentage of Participants Achieving Absolute Score >=20 for ACT in Participants Having a Confirmed Diagnosis of Asthma at Baseline
timeFrame: Up to 24 Months
measure: Percentage of Participants Starting on Upadacitinib 15 mg or 30 mg
timeFrame: Baseline
measure: Percentage of Participants with Modification of Upadacitinib Therapy, Timing of Modifications, and Reasons for Modifications
timeFrame: 24 Months
measure: Percentage of Participants with Modification of Concomitant AD Therapy, Timing of Modifications, and Reasons for Modifications
timeFrame: 24 Months
measure: Absolute Score for Skin Pain on the Atopic Dermatitis Symptom Scale (ADerm-SS)
timeFrame: Up to 24 Months
measure: Absolute Change from Baseline for Skin Pain on the ADerm-SS
timeFrame: Up to 24 Months
measure: Percent Change from Baseline for Skin Pain on the ADerm-SS
timeFrame: Up to 24 Months
measure: Absolute Score for Skin Cracking on the ADerm-SS
timeFrame: Up to 24 Months
measure: Absolute Change from Baseline for Skin Cracking on the ADerm-SS
timeFrame: Up to 24 Months
measure: Percent Change from Baseline for Skin Cracking on the ADerm-SS
timeFrame: Up to 24 Months
measure: Absolute Score for Validated Investigator Global Assessment Scale for Atopic Dermatitis (vIGA-AD) of Hand Eczema
timeFrame: Up to 24 Months
measure: Absolute Change from Baseline for vIGA-AD of Hand Eczema
timeFrame: Up to 24 Months
measure: Percent Change from Baseline for vIGA-AD of Hand Eczema
timeFrame: Up to 24 Months
measure: Absolute Score for vIGA-AD of Facial Eczema
timeFrame: Up to 24 Months
measure: Absolute Change from Baseline for vIGA-AD of Facial Eczema
timeFrame: Up to 24 Months
measure: Percent Change from Baseline for vIGA-AD of Facial Eczema
timeFrame: Up to 24 Months
measure: Absolute Score for Pruritis (5-D Pruritis Scale)
timeFrame: Up to 24 Months
measure: Absolute Change from Baseline for Pruritis (5-D Pruritis Scale)
timeFrame: Up to 24 Months
measure: Percent Change from Baseline for Pruritis (5-D Pruritis Scale)
timeFrame: Up to 24 Months
measure: Absolute Score for Flare Frequency
timeFrame: Up to 24 Months
measure: Absolute Change from Baseline for Flare Frequency
timeFrame: Up to 24 Months
measure: Percent Change from Baseline for Flare Frequency
timeFrame: Up to 24 Months
measure: Absolute Score for Flare Duration
timeFrame: Up to 24 Months
measure: Absolute Change from Baseline for Flare Duration
timeFrame: Up to 24 Months
measure: Percent Change from Baseline for Flare Duration
timeFrame: Up to 24 Months
measure: Absolute Score for Patient Self-Reported Global Assessment of Disease Severity (PtGA)
timeFrame: Up to 24 Months
measure: Absolute Change from Baseline for PtGA
timeFrame: Up to 24 Months
measure: Percent Change from Baseline for PtGA
timeFrame: Up to 24 Months
measure: Percentage of Participants Achieving PtGA <=2
timeFrame: Up to 24 Months
measure: Percentage of Participants Achieving PtGA Reduction >=1 from Baseline
timeFrame: Up to 24 Months
measure: Incidence and Type of Adverse Events
timeFrame: Up to 24 Months
Other outcomes:
Locations:
city: Heidelberg
country: Germany
facility: Durani & Durani, Heidelberg,DE /ID# 249172
state: Baden-Wuerttemberg
city: Heidelberg
country: Germany
facility: Universitaetsklinik Heidelberg /ID# 245834
state: Baden-Wuerttemberg
city: Langenau
country: Germany
facility: Hautarztpraxis Langenau /ID# 242279
state: Baden-Wuerttemberg
city: Stuttgart
country: Germany
facility: Flegl MD Stuttgart Germany /ID# 250302
state: Baden-Wuerttemberg
city: Freising
country: Germany
facility: Kurzen, Freising, DE /ID# 241845
state: Bayern
city: Memmingen
country: Germany
facility: Beldio Research GmbH /ID# 245830
state: Bayern
city: Munich
country: Germany
facility: Dermazent /Id# 268146
state: Bayern
city: Nuremberg
country: Germany
facility: Voelkel, Nuremberg, DE /ID# 252445
state: Bayern
city: Wuerzburg
country: Germany
facility: Hautarzte im Novum Medicum Dr. Kreienkamp & Sautter /ID# 276060
state: Bayern
city: Falkensee
country: Germany
facility: Praxis Dres. Freitag/Knoell /ID# 242278
state: Brandenburg
city: Kleinmachnow
country: Germany
facility: Dermatologie Kleinmachnow /ID# 268383
state: Brandenburg
city: Panketal
country: Germany
facility: Praxis Dr. Behnke /ID# 248870
state: Brandenburg
city: Potsdam
country: Germany
facility: Praxis Dr. Asadullah /ID# 243944
state: Brandenburg
city: Potsdam
country: Germany
facility: Hautärzte am Nauener Tor /ID# 261533
state: Brandenburg
city: Bensheim
country: Germany
facility: Hautarztpraxis Dr. Alexander Magerl /ID# 270749
state: Hessen
city: Frankfurt am Main
country: Germany
facility: Universitaetsklinikum Frankfurt /ID# 241766
state: Hessen
city: Oberursel
country: Germany
facility: MediCorium Zentrum fuer Dermatologie und Aesthetik /ID# 243328
state: Hessen
city: Oberursel
country: Germany
facility: MediCorium Zentrum fuer Dermatologie und Aesthetik /ID# 249180
state: Hessen
city: Wiesbaden
country: Germany
facility: Hautcentrum Wiesbaden /ID# 274848
state: Hessen
city: Greifswald
country: Germany
facility: Herrmann, Greifswald, DE /ID# 241889
state: Mecklenburg-Vorpommern
city: Bramsche
country: Germany
facility: Studienzentrum an der Hase GbR Dr. Weyergraf/Dr. Frick/Thomas Heiber /ID# 241658
state: Niedersachsen
city: Hannover
country: Germany
facility: Praxis Dres. Kaspari /Schenck /ID# 241688
state: Niedersachsen
city: Aachen
country: Germany
facility: Hoeller-Obrigkeit, Aachen, DE /ID# 245430
state: Nordrhein-Westfalen
city: Bielefeld
country: Germany
facility: Klinikum Rosenhoehe /ID# 241601
state: Nordrhein-Westfalen
city: Bochum
country: Germany
facility: Katholisches Klinikum Bochum gGmbH /ID# 270537
state: Nordrhein-Westfalen
city: Remscheid
country: Germany
facility: Kramer/Mortazawi, Remscheid /ID# 241824
state: Nordrhein-Westfalen
city: Soest
country: Germany
facility: Karl, Soest, DE /ID# 241909
state: Nordrhein-Westfalen
city: Andernach
country: Germany
facility: Bell, Andernach, DE /ID# 249154
state: Rheinland-Pfalz
city: Koblenz
country: Germany
facility: Grossmann, Koblenz, DE /ID# 242992
state: Rheinland-Pfalz
city: Mainz
country: Germany
facility: Hautarztpraxis Dr. Kirschner /ID# 266738
state: Rheinland-Pfalz
city: Selters
country: Germany
facility: CMS3 Company for Medical Study /ID# 241659
state: Rheinland-Pfalz
city: Simmern
country: Germany
facility: Dermatologisches Studienzentrum am Haut- und Laserzentrum /ID# 243882
state: Rheinland-Pfalz
city: Merzig
country: Germany
facility: HMS GmbH Zimmer /ID# 241657
state: Saarland
city: Magdeburg
country: Germany
facility: Praxis Dr. Raschke /ID# 251398
state: Sachsen-Anhalt
city: Chemnitz
country: Germany
facility: Praxis P. Hausler-Mehlhorn /ID# 241527
state: Sachsen
city: Leipzig
country: Germany
facility: Neubauer, Leipzig, DE /ID# 241823
state: Sachsen
city: Elmshorn
country: Germany
facility: Praxis Dr. Mempel /ID# 241827
state: Schleswig-Holstein
city: Kiel
country: Germany
facility: Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 240096
state: Schleswig-Holstein
city: Mölln
country: Germany
facility: Dermatologie Moelln Praxis Dr. Bodo Segert /ID# 242280
state: Schleswig-Holstein
city: Friedrichroda
country: Germany
facility: Praxis Liebetrau /ID# 271896
state: Thueringen
city: Ahaus
country: Germany
facility: Petri, Ahaus, DE /ID# 243452
city: Ahlen
country: Germany
facility: Dr. Stoeber /ID# 251066
city: Augsburg
country: Germany
facility: Praxis Dr. Mihaescu /ID# 241825
city: Bad Camberg
country: Germany
facility: MVZ medicum.mittelhessen /ID# 266126
city: Bad Kreuznach
country: Germany
facility: Mauer, Bad Kreuznach, DE /ID# 241990
city: Bergen
country: Germany
facility: Timmel/Timm/Vorwerk, Bergen /ID# 241661
city: Berlin
country: Germany
facility: Hautarztpraxis Dr. med. Christiane Handrick /ID# 262667
city: Berlin
country: Germany
facility: Praxis Dermatologie am Savigny /ID# 248846
city: Berlin
country: Germany
facility: Dre. Gellrich/Klein/Soost /ID# 250301
city: Berlin
country: Germany
facility: Schirmer, Berlin, DE /ID# 241684
city: Berlin
country: Germany
facility: Kors, Berlin, DE /ID# 241847
city: Berlin
country: Germany
facility: Dues/Manasterski, Berlin, DE /ID# 243885
city: Berlin
country: Germany
facility: Hautarztzentrum Tegel /ID# 241826
city: Berlin
country: Germany
facility: Haut Pur - Dermatologische Gemeinschaftspraxis /ID# 243943
city: Bingen am Rhein
country: Germany
facility: Hautarztpraxis Dr. Weid /ID# 265213
city: Blaubeuren
country: Germany
facility: Praxis fuer Innere Medizin/Rheumatologie /ID# 241846
city: Bogen
country: Germany
facility: Praxis T. Schadeck /ID# 241768
city: Borna
country: Germany
facility: Barth, Borna, DE /ID# 248871
city: Bremen
country: Germany
facility: Schwichtenberg, Bremen, DE /ID# 241683
city: Cologne
country: Germany
facility: Dr. Hoffmann /ID# 245423
city: Cologne
country: Germany
facility: Derma Köln /ID# 241856
city: Deggendorf
country: Germany
facility: Praxis Dr. Sbornik /ID# 241818
city: Delitzsch
country: Germany
facility: Hautmedizin Delitzsch /ID# 251394
city: Dresden
country: Germany
facility: Richter-Huhn, Dresden, DE /ID# 241822
city: Dueren
country: Germany
facility: Praxis Dr. Korge /ID# 241531
city: Freiburg im Breisgau
country: Germany
facility: Praxis Dr. Hong-Weldemann /ID# 248844
city: Friedberg (Hessen)
country: Germany
facility: Hautarztpraxis Friedberg Dr. med. Wilfried Jungkunz /ID# 248851
city: Gelsenkirchen
country: Germany
facility: Rotterdam, Gelsenkirchen, DE /ID# 241819
city: Gelsenkirchen
country: Germany
facility: Gemeinschaftspraxis Rietkoetter und Jablonka /ID# 241821
city: Gera
country: Germany
facility: Praxis Dr. Lange /ID# 241829
city: Gernsbach
country: Germany
facility: Loth, Gernsbach, DE /ID# 241828
city: Gießen
country: Germany
facility: Hautarztpraxis Dr. Budihardja /ID# 241851
city: Gladbeck
country: Germany
facility: Brinkmann & Partner, Gladbeck, /ID# 241850
city: Goslar
country: Germany
facility: Dr. Krueger /ID# 265150
city: Grossenhain
country: Germany
facility: Grossmann, Grossenhain, DE /ID# 250303
city: Hamburg
country: Germany
facility: Praxis Dr. Wegener /ID# 263731
city: Hamburg
country: Germany
facility: Cutaneum /ID# 249104
city: Hamburg
country: Germany
facility: Dermatologikum Hamburg /ID# 245431
city: Hamburg
country: Germany
facility: Hautarztpraxis Luetten/Sack /ID# 241534
city: Hamburg
country: Germany
facility: Dr. Wrage-Brors /ID# 262705
city: Hamburg
country: Germany
facility: Mensing Derma MVZ GmbH /ID# 272383
city: Hamburg
country: Germany
facility: Praxis Dr. Kasche /ID# 249102
city: Hanau
country: Germany
facility: MVZ Prof. Dr. Ockenfels Haut- und Allergie-Praxisklinik GmbH /ID# 245395
city: Haslach im Kinzigtal
country: Germany
facility: Dr. Buerkle /ID# 250299
city: Haßfurt
country: Germany
facility: Hautarztpraxis Haßberge /ID# 257648
city: Heilbad Heiligenstadt
country: Germany
facility: Gemeinschaftspraxis Dres. Anika Hünermund/Mario Pawlak /ID# 241908
city: Heilbronn
country: Germany
facility: Haut- u. Laserzentrum Heilbronn /ID# 250305
city: Heusenstamm
country: Germany
facility: Hausarztpraxis & Laserzentrum Dr. Zimmermann & Kollegen /ID# 251051
city: Ilmenau
country: Germany
facility: Praxis Dres. Bischoff/Danz /ID# 241852
city: Ingolstadt
country: Germany
facility: Stockmeier, Ingoldstadt, DE /ID# 248877
city: Juelich
country: Germany
facility: Hautarztpraxis Weidgang /ID# 248850
city: Karlsruhe
country: Germany
facility: Derma Sana /ID# 241854
city: Kempen
country: Germany
facility: Dermatologische Praxis Kempen /ID# 248852
city: Krefeld
country: Germany
facility: Praxis Dres. Bornemann/Reinerth /ID# 257649
city: Kulmbach
country: Germany
facility: Dres. Jacobs & Kollegen /ID# 241989
city: Leipzig
country: Germany
facility: Praxis Dres. Wiemers/Wiemers /ID# 241602
city: Lippstadt
country: Germany
facility: Haut- und Allergie-Zentrum Lippstadt /ID# 241929
city: Loehne
country: Germany
facility: Hagemeier, Loehne, DE /ID# 241886
city: Magdeburg
country: Germany
facility: Magdeburger Company for Medical Studies & Services GmbH /ID# 248849
city: Magdeburg
country: Germany
facility: MVZ "Im Altstadtquartier" Magdeburg /ID# 261366
city: Magdeburg
country: Germany
facility: Universitaetsklinikum Magdeburg /ID# 249174
city: Mainz
country: Germany
facility: Hausärzte am Fastnachtsbrunnen /ID# 250304
city: Mainz
country: Germany
facility: Dermatologie Quist-BAG Dres. med. Quist PartG /ID# 243325
city: Miltenberg
country: Germany
facility: Praxis A. Viculova /ID# 266133
city: Munich
country: Germany
facility: Dermatologie im Tal Praxis Dr.med. Maria Leibl /ID# 266128
city: Munich
country: Germany
facility: Hautzentrum am Marienplatz /ID# 248847
city: Munich
country: Germany
facility: Quack, Munich, DE /ID# 241536
city: Mutterstadt
country: Germany
facility: Dr. Gißler-Walter /ID# 248876
city: Mönchengladbach
country: Germany
facility: ZENTderma /ID# 241539
city: Münster
country: Germany
facility: Dr. Rezai /ID# 250298
city: Neu Wulmstorf
country: Germany
facility: Dermatologie im Apfelgarten /ID# 263704
city: Nuremberg
country: Germany
facility: Praxis Dr. Konstantin Ertner /ID# 249153
city: Oelde
country: Germany
facility: Hockmann, Oelde, DE /ID# 241906
city: Quedlinburg
country: Germany
facility: Harzklinikum Dorothea Christiane Erxleben /ID# 251067
city: Reutlingen
country: Germany
facility: Dr. Schaefers /ID# 255492
city: Schwelm
country: Germany
facility: Praxis Dr. Fränken /ID# 241853
city: Stadtroda
country: Germany
facility: Gemeinschaftspraxis fur Dermatologie /ID# 245831
city: Stuttgart
country: Germany
facility: Praxis Dr. Termeer /ID# 241662
city: Vechta
country: Germany
facility: Jasnoch/Kock/Borrosch, Vechta, /ID# 252081
city: Waltershausen
country: Germany
facility: Barnikol, Waltershausen, DE /ID# 241844
city: Wasserburg A. Inn
country: Germany
facility: Praxis Dehmel / Brand-Opitzer /ID# 243884
city: Werne
country: Germany
facility: Dr. Barbara Kempkes, Werne /ID# 241910
city: Wiesbaden
country: Germany
facility: Dr. med. Nicola Möller & Thomas Kurtenbach GbR Dermatologie im Zentrum /ID# 266130
city: Witten
country: Germany
facility: Hautarztpraxis Dr. med. Matthias Hoffmann /ID# 241907
city: Wurzen
country: Germany
facility: Albrecht, Wurzen, DE /ID# 241988
Study officials:
affiliation: AbbVie
name: ABBVIE INC.
role: STUDY_DIRECTOR
References: