Clinical trial NCT03304483: Cardiovascular Responses to Spartathlon Running
Official title: Cardiovascular Effects of Ultramarathon Running
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Disorder Heart
Lead sponsor: Aristotle University Of Thessaloniki
Sponsor class: OTHER
First posted: 2017-10-09
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Maximum age (years): 67
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: athletes participating in the ultra marathon running
Primary purpose: SCREENING

Brief summary: The aim of this study is to examine the cardiovascular effects of ultramarathon running and their relation to performance.

Detailed description: The purpose of the study is to determine the changes of cardiovascular morphology and function after an ultramarathon race. 50 entrants to the "Spartathlon 2017" 246-km running race will participate in the study. Cardiac and arterial morphology and function tests will be conducted one day before the race and within 20 minutes of race completion.

Eligibility criteria: Inclusion Criteria:

* Runners at least 18 years old, healthy and sufficiently trained.
* Runners being accepted to participate in the Spartathlon race according to the eligibility criteria (http://www.spartathlon.gr/en/registration-en.html)
* Runners who will volunteer to be examined pre- and post the race

Exclusion Criteria:

* Runners with chronic diseases
* Runners receiving any medication

Primary outcomes:
measure: Change of right ventricular function after one day ultra-marathon running
timeFrame: before and after 1 day running
Secondary outcomes:
measure: Change of left ventricular function after one day ultra-marathon running
timeFrame: before and after 1 day running
measure: Change of carotid artery function after one day ultra-marathon running
timeFrame: before and after 1 day running
Other outcomes:
Locations:
city: Thessaloniki
country: Greece
facility: Laboratory of Sports Medicine
Study officials:
affiliation: Aristotle University of Thessaloniki, Greece
name: Evangelia Kouidi, Professor
role: PRINCIPAL_INVESTIGATOR
References:
citation: Seedhouse EL, Walsh ML, Blaber AP. Heart rate, mean arterial blood pressure, and pulmonary function changes associated with an ultraendurance triathlon. Wilderness Environ Med. 2006 Winter;17(4):240-5. doi: 10.1580/pr27-05-r1.1.
citation: Millet GP, Millet GY. Ultramarathon is an outstanding model for the study of adaptive responses to extreme load and stress. BMC Med. 2012 Jul 19;10:77. doi: 10.1186/1741-7015-10-77.
citation: Cote AT, Phillips AA, Foulds HJ, Charlesworth SA, Bredin SS, Burr JF, Koehle MS, Warburton DE. Sex differences in cardiac function after prolonged strenuous exercise. Clin J Sport Med. 2015 May;25(3):276-83. doi: 10.1097/JSM.0000000000000130.
citation: Jee H, Park J, Oh JG, Lee YH, Shin KA, Kim YJ. Effect of a prolonged endurance marathon on vascular endothelial and inflammation markers in runners with exercise-induced hypertension. Am J Phys Med Rehabil. 2013 Jun;92(6):513-22. doi: 10.1097/PHM.0b013e31829232db.
citation: Blaber AP, Walsh ML, Carter JB, Seedhouse EL, Walker VE. Cardiopulmonary physiology and responses of ultramarathon athletes to prolonged exercise. Can J Appl Physiol. 2004 Oct;29(5):544-63. doi: 10.1139/h04-035.