Clinical trial NCT01985854: Conversion From Total Intravenous Anesthesia Technique to Desflurane Anesthesia for Long Duration Neurosurgery
Official title: Conversion From Total Intravenous Anesthesia Technique to Desflurane Anesthesia for Long Duration Neurosurgery: A Pilot Study for Assessment of Recovery Parameters
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Patients Undergoing Elective Craniotomy
Keywords: Desflurane
Propofol
Total intravenous anesthesia
Neurosurgery
Lead sponsor: Tokyo Women's Medical University
Sponsor class: OTHER
Collaborators: name: Baxter Healthcare Corporation
First posted: 2013-11-15
Enrollment: 60
Sex: ALL
Minimum age (years): 20
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Since neurological testing during neurosurgery, such as somato-sensory evoked potentials, motor-evoked potentials, auditory evoked potentials and visual evoked potentials are well maintained their wave-form reactivity with total intravenous anaesthesia technique better than inhalational anesthetic techniques, the standard anesthesia method for neurosurgery is usually total intravenous anaesthesia technique. Nonetheless, after finishing recording the evoked potential responses during surgery, facilitation of recovery from general anesthesia is getting important, because the real neurological physical examination is much more sensitive than above electrical evoked potentials to evaluate the results of surgical operation.

We propose to evaluate the recovery parameters after conversion from total intravenous anaesthesia technique to Desflurane anesthesia during long term neurosurgery procedures. The conversion will be initiated upon completion of the neurophysiological electric evoked potentials assessment. Based on the pharmacological properties of desflurane, we hypothesize that recovery after conversion to Desflurane will be faster compared to recovery after total intravenous anaesthesia alone.


Eligibility criteria: Inclusion Criteria:

* Patients undergoing elective craniotomy
* American Society of Anesthesiology Physical Status Ⅰ, II and III
* Age: between 20 to 65 years
* Sex: male or female
* Patients who are postmenopausal or surgically sterilized
* Expected Operation time is longer than 4 hours.

Exclusion Criteria:

-

Primary outcomes:
measure: Time from the discontinuation of anesthesia to extubation
timeFrame: Patients will be followed in the operation room, an expected average of 30 minutes.
Secondary outcomes:
measure: Time from the discontinuation of anesthesia to eye opening
timeFrame: At the end of surgery, duration time from the discontinuation of anesthesia to the eye opening will be measured, averaged expected time is 30 minutes
measure: Cognitive function
timeFrame: Up to 24 hours
measure: Time from the discontinuation of anesthesia to orientation
timeFrame: Up to 24 hours
Other outcomes:
measure: Length of ICU stay
timeFrame: Patients will be followed for the duration of intensive care unit stay, an expected average of 1 week
Locations:
city: Tokyo
country: Japan
facility: Tokyo Women's Medical University Hospital
Study officials:
affiliation: Tokyo Women's Mecical University, Department of Anesthesiology
name: Makoto Ozaki, Ph.D
role: STUDY_CHAIR
References: