louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04561141: Post Covid Syndrome: Clinical Pattern and Functional Assessment
Official title: Post Covid Syndrome: Clinical Pattern and Functional Assessment
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Covid19
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2020-09-23
Enrollment: 85
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: will be carried out in Assuit university hospital among health team workers(doctors, nurses, employes), in Emergency room(ER) , clinics , ICU and wards for patients who had covid 19

Brief summary: Aim(s) of the Research :

1. Identify post covid symptoms
2. prevalance of post covid syndrome among survivours

Detailed description: There is currently very limited information on the nature and prevalence of post-COVID-19 symptoms after hospital discharge. On 11th March 2020, corona virus disease 2019 (COVID-19) was declared a global pandemic by the World Health Organisation (WHO). Egypt has been one of the worst affected countries with over 101,500 confirmed cases and more than 5,696 confirmed deaths at the time of writing (17/9 2020) .1 COVID-19 is caused by the corona virus SARSCoV-2 and presents with a wide spectrum of clinical symptoms. Wu et al reported that 81% of people with COVID-19 in China presented with mild symptoms; 14% presented with symptoms of severe respiratory dysfunction; and 5% developed a critical illness with respiratory failure, septic shock, and multiple organ dysfunction or failure.2 The medium and long-term problems experienced by survivors of COVID-19 after discharge from hospital are currently unknown, but there is some emerging evidence. An Italian study followed-up 143 individuals 7 weeks post-discharge and found 53% reporting fatigue, 43% breathlessness and 27% joint pain.3 Post-discharge symptoms may also be predicted from the previous coronavirus outbreaks of Severe Acute Respiratory Syndrome (SARS) in 2002 and Middle East Respiratory Syndrome (MERS) in 2012. A meta-analysis of 28 follow-up studies found that one quarter of hospitalised survivors of SARS and MERS had reduced lung function and exercise capacity at six months post-discharge.4 At one year, post-traumatic stress disorder (PTSD), depression and anxiety, and reduced quality of life were observed Specific data concerning the rehabilitation needs of this group is therefore urgently required.

Eligibility criteria: Inclusion Criteria:

1. patients diagnosed as covid 19 with chest ct and/or nasopharyngeal swab for covid 19
2. age 18 years old and above
3. post covid syndrome after 6 weeks

Exclusion Criteria:

* 1-below age of 18 2 -not confirmed cases 3. symptoms less than 6 weeks

Primary outcomes:
measure: Identify post covid symptoms
timeFrame: after 4 weeks of diagnosis
Secondary outcomes:
measure: prevalance of post covid syndrome among survivours
timeFrame: after 4 weeks of diagnosis
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02143141: Low Pain Prediction in Cesarean Section Patients
Official title: Eliminating Long Acting Spinal Narcotic Use and Its Associated Side Effects for Those Who do Not Need it After Cesarean Delivery
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE4
Conditions: Scheduled Cesarean Sections
Postoperative Pain Management
Side Effects
Keywords: postoperative pain
narcotic side effects
Lead sponsor: Wake Forest University Health Sciences
Sponsor class: OTHER
First posted: 2014-05-20
Enrollment: 13
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The investigators are attempting to see if eliminating the amount of long acting spinal narcotic during cesarean section delivery will demonstrate pain scores with movement when evaluated 24 hours postoperatively as those that receive the standard dosage of spinal narcotic when combined with oral acetaminophen or placebo. The investigators also are evaluating if there are decreased side effects related to decreased narcotic usage.

Detailed description: Subjects are randomized on the morning of surgery to receive a standard dose of spinal narcotic or to receive no long acting spinal narcotic. The subjects may or may not also receive acetaminophen orally postoperatively. Pain scores are done on postoperative day one as well as evaluation of potential narcotic side effects such as nausea/vomiting, itching, and sedation.

Eligibility criteria: Inclusion Criteria:

* anticipated pain level estimated to be in the lowest 20th percentile (calculated \<34.3 utilizing our standard preoperative questionnaire)
* age \>/= 18
* not allergic to any study medications to be utilized in this study
* singleton pregnancy

Exclusion Criteria:

* allergies to morphine or acetaminophen
* diagnosis of a chronic pain disorder
* weight \>300 lbs
* hepatic disease

Primary outcomes:
measure: Pain
timeFrame: 24 hours
Secondary outcomes:
measure: Itching
timeFrame: 24 hours
measure: Nausea/Vomiting
timeFrame: 24 hours
Other outcomes:
Locations:
city: Winston-Salem
country: United States
facility: Forsyth Medical Center
state: North Carolina
Study officials:
affiliation: Wake Forest University Health Sciences
name: Jessica Booth, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01507441: Studying DNA in Samples From Younger Patients With Down Syndrome and Acute Myeloid Leukemia Treated on COG-AAML0431 Clinical Trial
Official title: Whole Exon Sequencing of Down Syndrome Acute Myeloid Leukemia
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Leukemia
Keywords: childhood myelodysplastic syndromes
childhood acute myeloid leukemia/other myeloid malignancies
childhood acute megakaryocytic leukemia (M7)
Lead sponsor: Children's Oncology Group
Sponsor class: NETWORK
Collaborators: name: National Cancer Institute (NCI)
First posted: 2012-01-10
Enrollment: 10
Sex: ALL
Maximum age (years): 3
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Down syndrome children diagnosed with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS).

Brief summary: RATIONALE: Studying samples of blood, tissue, and bone marrow from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.

PURPOSE: This research trial studies DNA samples from patients with Down syndrome and acute myeloid leukemia treated on COG-AAML0431 clinical trial.

Detailed description: OBJECTIVES:

* To identify new genetic abnormalities associated with acute myeloid leukemia (AML) in patients with Down syndrome through whole-genome sequencing.

OUTLINE: This is a multicenter study.

Extracted DNA and RNA from cryopreserved specimens are analyzed for genomic sequencing, gene mutation, and microarray analysis.

Eligibility criteria: DISEASE CHARACTERISTICS:

* Down syndrome children diagnosed with acute myeloid leukemia (AML) or myelodysplastic syndromes (MDS)
* Clinical samples from patients enrolled on the Children's Oncology Group (COG) AAML0431 phase III clinical trial, and from the Children's Hospital of Michigan Cell Bank

  * Diagnostic blast samples and matched remission samples

PATIENT CHARACTERISTICS:

* Not specified

PRIOR CONCURRENT THERAPY:

* Not specified

Primary outcomes:
measure: Identification of unique mutations through whole-genome sequencing
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Children's Hospital of Michigan
name: Jeffrey Taub, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00886041: Role of Laparoscopy in Unexplained Infertility
Official title: Role of Laparoscopy in Unexplained Infertility
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Infertility
Keywords: laparoscopy
unexplained infertility
Lead sponsor: Mansoura University
Sponsor class: OTHER
First posted: 2009-04-22
Enrollment: 512
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: In this randomized controlled trial the investigators were looking for the best policy for management of women with unexplained infertility after normal hysterosalpingogram (HSG). The investigators test the hypothesis that postponing or even bypassing laparoscopy does not affect the outcome of management of women with apparently unexplained infertility.


Eligibility criteria: Inclusion Criteria:

* failure of conception for at least one year
* no pathology demonstrated after the standard infertility work-up including semen analysis, mid-luteal serum progesterone for confirming ovulation and hysterosalpingography for documenting tubal patency
* diagnosed as having unexplained infertility

Primary outcomes:
measure: The outcome measure was the occurrence of clinical pregnancy and miscarriage.
timeFrame: 5 years
Secondary outcomes:
Other outcomes:
Locations:
city: Mansoura
country: Egypt
facility: Mansoura University Hospitals
state: Dakahalia
Study officials:
affiliation: Mansoura University
name: ahmed m badawy, MD PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06091241: ESPBs Vs TAPs for Satisfactory Analgesia Following DIEP Surgery
Official title: ESPBs Vs TAPs for Satisfactory Analgesia Following DIEP Surgery
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Pain
Lead sponsor: University of Kansas Medical Center
Sponsor class: OTHER
First posted: 2023-10-19
Enrollment: 102
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Breast cancer is the second most common cancer diagnosed in American women . For patients who have undergone surgical mastectomy, autologous breast reconstruction is an alternative option to breast implants. Deep Inferior Epigastric Perforator (DIEP) flaps are the gold standard for autologous breast reconstruction . Effective pain control following surgery is imperative and ultrasound-guided bilateral transversus abdominis plane blocks (TAPs) with the infiltration of local anesthetics, such a bupivacaine are a common regional technique of choice . A newer described technique, bilateral Erector Spinae Plane blocks (ESPBs) (which also are an infiltration of local anesthetic) present as an alternative approach for post-operative analgesia. ESPBs have been proven efficacious in reducing intra- and post-operative opioid requirements, lessening the need for rescue analgesics in other similar surgical procedures.

The hypothesis is that preoperative bilateral ESPBs could provide equivalent pain control as a regional analgesic for patients undergoing DIEP flap surgery when compared to preoperative bilateral TAPs


Eligibility criteria: Inclusion Criteria:

* Adult women with breast cancer, ASA 1-3, undergoing DIEP flap surgery

Exclusion Criteria:

* Chronic opioid use contraindications to local anesthetics or regional analgesia Inability to communicate intensity of pain on a numeric analog scale

Primary outcomes:
measure: Numerical Rating Scale
timeFrame: 24 hours post injection
measure: Mean Morphine Equivalents
timeFrame: 24 hours post injection
Secondary outcomes:
measure: Numerical Rating Scale
timeFrame: 12 hours post injection
measure: Michigan Body Map
timeFrame: 24 hours post injection
measure: Mean Morphine Equivalents
timeFrame: 48 hours post injection
measure: Numerical Rating Scale
timeFrame: 48 hours post injection
measure: Numerical Rating Scale
timeFrame: 3 months post-operation
measure: Numerical Rating Scale
timeFrame: 6 months post-operation
Other outcomes:
Locations:
city: Kansas City
country: United States
facility: University of Kansas Medical Center
state: Kansas
Study officials:
References:
Clinical trial NCT06439641: Prevalence and Factors Associated With Sleep Disorders in Inflammatory Bowel Disease
Official title: Prevalence and Factors Associated With Sleep Disorders in Inflammatory Bowel Disease: a Cross-sectional Study at Reims University Hospital
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Inflammatory Bowel Diseases
Crohn Disease
Ulcerative Colitis
Sleep Disorder
Keywords: Inflammatory Bowel Diseases
Crohn's Disease
Ulcerative Colitis
Sleep Disorders
Lead sponsor: CHU de Reims
Sponsor class: OTHER
First posted: 2024-06-03
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Inflammatory bowel diseases (IBD) including Crohn's disease (CD) and ulcerative colitis (UC), are an inflammatory disease that can affect the entire digestive tract from the mouth to the anus for CD and the entire colon and rectum for UC. They mainly affect adolescents and young adults. These pathologies evolve in relapses interspersed with phases of remission. Sometimes associated with extraintestinal manifestations (joint, dermatological, ophthalmological or biliary systems), chronic inflammation of the digestive tract and the resulting symptoms (abdominal pain, diarrhea, rectal syndrome, etc.) lead to a significant alteration in the quality of life of patients in all spheres of activity (professional, sexual, social).

Sleep is a basic neurophysiological state, the normal total duration of which in humans is between six and ten hours per day. It is an essential element of the circadian rhythm in humans, influencing certain cellular functions and in particular the synthesis of cytokines and pro-inflammatory molecules. Sleep disturbances and disruption of the circadian rhythm lead to metabolic and immunological dysfunctions, which may be involved in chronic inflammatory conditions through changes in the immune response.

In the field of IBD, many studies suggest poor sleep quality in patients with IBD. While there seems to be a link between sleep disorders and impaired quality of life with a socio-professional impact in these patients, the links between IBD activity, its treatment and sleep disorders are poorly studied, with discordant results in previous studies.

In order to enrich our knowledge on this topic, the investigators wish to study the prevalence and risk factors associated with sleep disorders in IBD patients in order to improve patients' quality of life


Eligibility criteria: Inclusion Criteria:

* Adult patients with Crohn's disease (CD) or ulcerative colitis (UC) presenting for consultation or hospitalization in Gastroenterology unit

Exclusion Criteria:

* Patients with an identified sleep pathology

Primary outcomes:
measure: Pittsburgh Sleep Quality Index Questionnaire
timeFrame: Only one time at inclusion
Secondary outcomes:
Other outcomes:
Locations:
city: Reims
country: France
facility: Chu Reims
Study officials:
References:
Clinical trial NCT02006836: Glycemic Responses to Majia Pomelos in Type 2 Diabetic Patients
Official title: Glycemic Index & Glycemic Responses to Majia Pomelos
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Diabetes
Keywords: glycemic index
glycemic response
diabetes
pomelo
Lead sponsor: Huazhong University of Science and Technology
Sponsor class: OTHER
First posted: 2013-12-10
Enrollment: 59
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Food intake has a great influence on blood glucose of patients with diabetes. This study was designed to determine the glycemic index (GI) of a particular pomelo named Majia pomelo and its effects on postprandial glucose (PPG) excursions in both healthy subjects and patients with type 2 diabetes (T2DM).

Detailed description: The purpose of this study was to evaluate the GI and effects on glucose excursion of Majia pomelo in both healthy and diabetic subjects. The results may help diabetic subjects and their health care providers in developing a diet that is both medically and culturally appropriate.

Eligibility criteria: Inclusion Criteria:

* In the diabetic and diabetic 2 groups, it required that their diabetes was controlled (HbA1c ≤ 8%) on diet with or without metformin.

Exclusion Criteria:

* Morbid obesity (BMI \> 40 kg/m2)
* Pre diabetes
* Pregnancy
* Presence of gastroenterological disorders
* Alimentary tract surgery
* A history of gastroenteritis in the prior six months
* Any alcohol intake
* Smoking
* Taking any medications (except metformin)
* Poorly controlled diabetes (HbA1c \> 8%)
* Presence of chronic diseases (such as bronchial asthma or rheumatoid arthritis) or acute illness (such as upper respiratory tract or urinary tract infection)

Primary outcomes:
measure: Glycemic Index
timeFrame: 3 days
measure: ∆g of Breakfast With/Without Pomelo
timeFrame: 9 days
measure: ∆g of Lunch With/Without Pomelo
timeFrame: 9 days
measure: ∆g of Dinner With/Without Pomelo
timeFrame: 9 days
measure: AUCs With/Without Pomelo
timeFrame: 9 days
Secondary outcomes:
Other outcomes:
Locations:
city: Wuhan
country: China
facility: Tongji Hospital
state: Hubei
Study officials:
affiliation: Division of Endocrinology, Tongji Hospital, Huazhong University of Science & Technology
name: Xuefeng Yu, PhD MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06266936: Smart Life Smart Living Intercontinental - Medical Students' Cohort
Official title: Smart Life Smart Living Intercontinental - Medical Students' Cohort
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Mental Health Issue
Student Burnout
Lead sponsor: University Hospital, Grenoble
Sponsor class: OTHER
Collaborators: name: University Grenoble Alps
First posted: 2024-02-20
Enrollment: 1564
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The study concerns students over the age of 18 who are regularly enrolled in healthcare courses at a French university.

The study involves longitudinal monitoring of the state of health of the specific population of students in care courses, from their entry into university studies (first year) until their final year of study, i.e. from 5 to 13 years depending on the course and the different universities.

Brief summary: The question of the well-being, quality of life and mental health of care students is unanimously considered to be a central issue among young adults. According to the French Ministry of Higher Education and Research, there will be 194,752 care students in France in 2021-2022. The quality of life and well-being of health students can be affected at several levels. The first is mental health. In France, the mental health of these students has deteriorated considerably in recent years. According to a 2017 survey of 21,768 French medical students, 66% of them had an anxiety disorder and 27% a depressive syndrome. In addition, a number of risk factors have been identified for the mental health of health students.

The aim of the study is to carry out a longitudinal evaluation of the mental health status of care students during their university studies in France through anxiety, depression and perceived stress.


Eligibility criteria: Inclusion Criteria:

* students who are regularly enrolled in healthcare courses at a French university

Exclusion Criteria:

* Age under 18

Primary outcomes:
measure: Synthetic score on standardized assessment scale of anxiety
timeFrame: 1 hour
Secondary outcomes:
measure: Synthetic score on standardized assessment scale of mental health
timeFrame: 1 hour
measure: Synthetic score on standardized assessment scale of stress
timeFrame: 1 hour
Other outcomes:
Locations:
Study officials:
affiliation: University Grenoble Alps
name: Nicolas Vuillerme, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT02535936: Cortical Plasticity in Spastic Diplegia After Selective Dorsal Rhizotomy
Official title: Cortical Plasticity in Spastic Diplegia After Selective Dorsal Rhizotomy
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Spastic Diplegia
Keywords: Cerebral Palsy
Lead sponsor: The University of Texas Health Science Center, Houston
Sponsor class: OTHER
First posted: 2015-08-31
Enrollment: 15
Sex: ALL
Minimum age (years): 3
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The purpose of this study is to characterize the cortical connectivity changes in the brain of spastic diplegic children after Selective Dorsal Rhizotomy.

Detailed description: To establish the structural changes in the corticopyramidal tract using diffusion tractography imaging (DTI) due to selective dorsal rhizotomy and compare the resting state functional connectivity(rsfcMRI) temporal latency differences of spastic diplegics for Selective Dorsal Rhizotomy.

Eligibility criteria: Inclusion Criteria:

* Children diagnosis with Spastic Diplegia and having Selective Dorsal Rhizotomy surgery

Exclusion Criteria:

* No Selective Dorsal Rhizotomy surgery

Primary outcomes:
measure: Change in Fractional Anisotropy as assessed by brain MRI with diffusion tractography imaging (DTI) sequences
timeFrame: Baseline and 12 months
measure: Change in Mean Diffusivity as assessed by brain MRI with diffusion tractography imaging (DTI) sequences
timeFrame: Baseline and 12 months
measure: Change in Radial Diffusivity as assessed by brain MRI with diffusion tractography imaging (DTI) sequences
timeFrame: Baseline and 12 months
measure: Change in Axial Diffusivity as assessed by brain MRI with diffusion tractography imaging (DTI) sequences
timeFrame: Baseline and 12 months
Secondary outcomes:
Other outcomes:
Locations:
city: Houston
country: United States
facility: UTHealth & Children's Memorial Hermann Hospital
state: Texas
Study officials:
affiliation: UTHealth Medical School
name: Manish N Shah, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04626336: Post-operative Hernias After Radical Cystectomy
Official title: Post-operative Hernias After Radical Cystectomy : Incidence and Risks Factors
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Evisceration; Traumatic
Hernia
Keywords: Median hernia
Parastomal hernia
Cystectomy
Lead sponsor: University Hospital, Montpellier
Sponsor class: OTHER
First posted: 2020-11-12
Enrollment: 800
Sex: ALL
Minimum age (years): 40
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients who undergo cystectomy for cancer or not at the CHU de Montpellier, Nîmes and the Beau Soleil clinic

Brief summary: Post-operative hernias after cystectomy are frequent (our review of the literature with meta-analysis found an incidence of evisceration at 5%, median eventrations at 8% and peristomal hernias at 14%). These represent a non-negligible and partially morbidity. avoidable, subject to proper assessment of personal and surgical risk factors


Eligibility criteria: Inclusion criteria:

* having undergone a cystectomy (for cancer or not),
* with or without reconstruction, between 01/01/2010 and 12/31/2020

Exclusion criteria:

- refusing to participate

Primary outcomes:
measure: Type of post-operative hernias
timeFrame: 1 day
measure: Define risk factors Type of risks factors
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
city: Montpellier
country: France
facility: Uhmontpellier
Study officials:
affiliation: University Hospital, Montpellier
name: Guillaume Aujoulat
role: PRINCIPAL_INVESTIGATOR
References: