Clinical trial NCT02060097: Effects of Cocoa Flavanol on Skin Aging
Official title: Effects of 24-week Cocoa Flavanol Supplementation on Photo-aged Facial Skin
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Ageing
Photo-aging
Keywords: Anti-aging
High-flavanol cocoa
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2014-02-11
Enrollment: 64
Sex: FEMALE
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Photoaging is caused by the superposition of chronic ultraviolet (UV)-induced damage on the intrinsic aging process, and accounts for the majority of age-associated changes in skin appearance. Reactive oxygen species (ROS) likely contribute to this process. Strategies utilizing endogenous skin antioxidants as well as plant-derived or synthetic compounds have been examined.

Cocoa beans fresh from the tree are exceptionally rich in polyphenols, such as flavanol, and have a higher antioxidant capacity. The present study is designed to investigate the effects of long-term intake of a product rich in cocoa flavanols on facial wrinkles, hydration, elasticity and photosensitivity.


Eligibility criteria: Inclusion Criteria:

* Healthy females aged ≥ 40 years
* Facial wrinkle grade ≥ 2

Exclusion Criteria:

* received medical or cosmetic treatment that interferes with the general aging process at least 3 months before the study
* reported taking functional foods 1 month before the study
* history of acute or chronic disease such as severe liver or kidney disease or uncontrolled diabetes
* history of allergies against any component of trial foods
* any visible skin disease that might be confused with a skin reaction to the test procedure

Primary outcomes:
measure: Change from baseline in skin wrinkles at week 24
timeFrame: baseline, week 24
Secondary outcomes:
measure: Change from baseline in skin elasticity at week 24
timeFrame: baseline, week 24
measure: Change from baseline in minimal erythema dose at week 24
timeFrame: baseline, week 24
measure: Change from baseline in skin hydration at week 12
timeFrame: baseline, week 12
measure: Change from baseline in skin color at week 12
timeFrame: baseline, week 12
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
Study officials:
affiliation: Seoul National University Hospital
name: Jin Ho Chung, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Williams S, Tamburic S, Lally C. Eating chocolate can significantly protect the skin from UV light. J Cosmet Dermatol. 2009 Sep;8(3):169-73. doi: 10.1111/j.1473-2165.2009.00448.x.
citation: Heinrich U, Neukam K, Tronnier H, Sies H, Stahl W. Long-term ingestion of high flavanol cocoa provides photoprotection against UV-induced erythema and improves skin condition in women. J Nutr. 2006 Jun;136(6):1565-9. doi: 10.1093/jn/136.6.1565.
citation: Yoon HS, Kim JR, Park GY, Kim JE, Lee DH, Lee KW, Chung JH. Cocoa Flavanol Supplementation Influences Skin Conditions of Photo-Aged Women: A 24-Week Double-Blind, Randomized, Controlled Trial. J Nutr. 2016 Jan;146(1):46-50. doi: 10.3945/jn.115.217711. Epub 2015 Nov 18.