Clinical trial NCT03835533: Platform Study for Prostate Researching Translational Endpoints Correlated to Response to Inform Use of Novel Combinations
Official title: A Multicenter, Open-Label, Exploratory Platform Study to Evaluate Biomarkers and Immunotherapy Combinations for the Treatment of Patients With Metastatic Castration-resistant Prostate Cancer
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Metastatic Castration-resistant Prostate Cancer
Keywords: Metastatic Castration-resistant Prostate Cancer
Immunotherapy
Platform study
NKTR-214
Nivolumab
CDX-301
Poly-ICLC
INO-5151
Lead sponsor: Parker Institute for Cancer Immunotherapy
Sponsor class: OTHER
Collaborators: name: Bristol-Myers Squibb
name: Celldex Therapeutics
name: Cancer Research Institute, New York City
name: Inovio Pharmaceuticals
name: Oncovir, Inc.
First posted: 2019-02-08
Enrollment: 43
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study is designed to evaluate multiple clinical hypotheses and mechanistically-defined combinations to evaluate the safety and efficacy of immunotherapy combinations in participants with mCRPC who have received prior secondary androgen receptor signaling inhibitor therapy (eg, abiraterone, enzalutamide, apalutamide).

Detailed description: This is an open-label, non-randomized, exploratory platform protocol designed to assess the safety and antitumor activity of multiple immunotherapy combinations in participants with mCRPC who have received prior therapy. The platform study will consist of 2 stages: Stage 1, an initial stage to evaluate safety, biomarkers, and clinical activity of a combination and Stage 2, an expanded cohort, when warranted, based on the safety, clinical activity, and/or biomarker results from Stage 1. The Sponsor intends to modify and/or add new combinations to the protocol as data emerge from this and other trials.

Participants must provide consent for archival tissue from a prior biopsy or surgery for prostate cancer and must consent to baseline and on-treatment biopsies, if medically feasible. Participants will be assigned to receive one of the enrolling combination study interventions and will be monitored for safety and response.

Eligibility criteria: Key Inclusion Criteria:

1. Metastatic castration resistant prostate cancer with castrate-level testosterone (\< 50 ng/dL) at screening.
2. Disease progression per Prostate Cancer Working Group 3 (PCWG3) criteria.
3. Provide fresh pre-treatment core needle or incisional biopsy of a metastatic tumor lesion not previously irradiated. Fine needle aspiration is not acceptable.

   1. Additionally, if a pre-treatment biopsy is not medically feasible for participants with bone only disease, formalin-fixed paraffin-embedded (FFPE) tumor specimen in a paraffin block (preferred) or at least 10 slides containing unstained, freshly cut, serial sections must be provided.
   2. For all participants, in addition to fresh pre-treatment biopsy, consent for archival tissue is required.
4. Must be willing to undergo tumor biopsy(ies) on treatment, if medically feasible.
5. Have received and progressed on prior secondary androgen receptor signaling inhibitor therapy (eg, abiraterone, enzalutamide, apalutamide).
6. Participants must discontinue antiandrogen therapy (ie, bicalutamide, flutamide, nilutamide) at least 4-6 weeks prior to registration with no evidence of prostate-specific antigen (PSA) decline after washout.

   1. Bicalutamide: Washout period at least 6 weeks
   2. Flutamide and nilutamide: Washout period at least 4 weeks
7. Participants must discontinue therapies for mCRPC for 5 half-lives or 28 days, whichever is shorter.

   1. Participants will remain on gonadotropin-releasing hormone (GnRH) agents throughout this study.
   2. Prior chemotherapy is allowed if no progression of disease on chemotherapy as defined by PCWG3-modified RECIST 1.1.
   3. Prior treatment with sipuleucel-T, radium-223, or poly ADP ribose polymerase (PARP) inhibitor (eg, olaparib) is allowed.
   4. Tissue biopsy may be performed during washout period.

Key Exclusion Criteria:

1. Has a diagnosis of immunodeficiency or conditions that need systemic corticosteroid replacement therapy \> 10 mg/day prednisone (or equivalent) or other immunosuppressive medications within 28 days prior to the first dose of study intervention. Inhaled steroids are permitted if necessary.
2. Has any active known or suspected autoimmune disease. Participants with vitiligo, type I diabetes mellitus, controlled autoimmune hypothyroidism, psoriasis not requiring systemic treatment, or other conditions under control are permitted to enroll.
3. Has a known history of active TB (Bacillus Tuberculosis).
4. Has known history of, or any evidence of active, non-infectious pneumonitis.
5. Known history of testing positive for human immunodeficiency virus (HIV), known acquired immunodeficiency syndrome (AIDS), or any positive test for hepatitis B or hepatitis C virus representing acute or chronic disease.
6. Has received a live vaccine within 30 days of planned start of study intervention.

   Note: Seasonal influenza vaccines for injection are generally inactivated flu vaccines and are allowed; however intranasal influenza vaccines (eg, Flu-Mist®) are live attenuated vaccines, and are not allowed.
7. Has known active central nervous system (CNS) metastases and/or carcinomatous meningitis. Participants with previously treated brain metastases may participate provided they are stable (without evidence of progression by imaging for at least 4 weeks prior to the first dose of study intervention and any neurologic symptoms have returned to baseline), have no evidence of new or enlarging brain metastases, and are not using steroids for at least 7 days prior to study intervention. This exception does not include carcinomatous meningitis which is excluded regardless of clinical stability.

Primary outcomes:
measure: Number of Participants With Adverse Events (AE) and Serious Adverse Events (SAE)
timeFrame: For AEs, from initiation of study drug through 100 days after last dose, up to 24 months. For SAEs, from signing informed consent (prior to Screening) through 100 days after last dose, up to 24 months.
Secondary outcomes:
measure: Composite Response Rate (CRR)
timeFrame: Initiation of study drug through radiographic progression or initiation of new anti-cancer therapy, whichever occurred first, up to 20 months
measure: Disease Control Rate (DCR)
timeFrame: Initiation of study drug through radiographic progression or initiation of new anti-cancer therapy, whichever occurred first, up to 20 months
measure: Radiographic Progression-free Survival (rPFS)
timeFrame: Initiation of study drug through radiographic progression or initiation of new anti-cancer therapy, whichever occurred first, up to 20 months
measure: Overall Survival (OS)
timeFrame: From initiation of study drug until death due to any cause, up to 2.5 years
measure: Overall Survival (OS) at 12 Months
timeFrame: At 12 months
Other outcomes:
Locations:
city: Los Angeles
country: United States
facility: Angeles Clinic
state: California
city: San Francisco
country: United States
facility: University of California San Francisco
state: California
city: New York
country: United States
facility: Mount Sinai
state: New York
city: New York
country: United States
facility: Memorial Sloan Kettering Cancer Center
state: New York
city: Portland
country: United States
facility: Oregon Health & Science University
state: Oregon
city: Houston
country: United States
facility: The University of Texas MD Anderson Cancer Center
state: Texas
Study officials:
affiliation: Parker Institute for Cancer Immunotherapy
name: Parker Institute for Cancer Immunotherapy
role: STUDY_DIRECTOR
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