Clinical trial NCT04433078: RepurpoSing Old Drugs TO SuppRess a Modern Threat: COVID-19 STORM
Official title: RepurpoSing Old Drugs TO SuppRess a Modern Threat: The STORM Trial
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: PHASE2
Conditions: Cytokine Storm
SARS-CoV-2
Keywords: Doxycycline
Cytokine Storm
SARS-CoV-2
Lead sponsor: Temple University
Sponsor class: OTHER
First posted: 2020-06-16
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: This study will randomize 20 patients with confirmed or highly suspected early stage severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) patients to Doxycycline (100 mg BID) or Placebo.
Primary purpose: TREATMENT

Brief summary: The primary aim of this study is to test whether Doxycycline can benefit patients with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections by inhibiting the replication of the virus while at the same time blocking the development of cytokine storms or inhibiting cytokine-associated coagulopathy respectively. The investigators hypothesize that Doxycycline will will improve survival and reduce morbidity in SARS-CoV-2 infected patients.

A secondary aim is to identify genetic variants that predict either an unusually mild disease or an unusually severe disease - knowledge that can be used to design new and precise medications and to be able to predict patients who might get into early trouble and to therefore hospitalize them.

Detailed description: This study will randomize 20 patients with confirmed or highly suspected early stage severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to Doxycycline (100 mg BID) or Placebo and then assess the progression of their disease over the next three weeks with the primary endpoint being days alive and out of the hospital.

The investigators will collect specimens for measurement of viral burden (nasopharyngeal luminex (SARS-CoV-2), SARS-CoV-2 serum quantitative viral load, SARS-CoV-2 IgM/IgG antibodies), markers of inflammation (WBC, ESR, TNFa, IL-1, IL-6, IL-1B), and cardiac dysfunction (CRP, pro-BNP, hsTnT).

Eligibility will be based on history and physical examination findings - collated into a clinical suspicion score. The decision to enroll based on clinical suspicion score rather than confirmed SARS-CoV-2 disease is based on the variable and unacceptably high false negative rate of the nasopharyngeal PCR test for in early disease.

Clinical Suspicion Score: Greater than or equal to 6/20 (at least 4 points of which must be clinical) will be eligible for enrollment.

Clinical Criteria: Max 12 points

* Fever (2 points)
* Cough (2 points)
* Dyspnea (2 points)
* Chest pain (1 point)
* Myalgias (1 point)
* Fatigue (1 point)
* GI symptoms (1 point)
* Loss of Smell (1 point)
* Loss of Taste (1 point)

Exposure Criteria: Max 8 points

* Contact with known COVID+ (2 points)
* Healthcare worker -- frequent \<6 feet contact for 15 minutes (2 points)
* High-risk work -- supermarket, deli, transportation (2 points)
* Endemic community -- prison/jail/nursing home/LTAC/SNF/rehab/homeless/homeless shelter (2 points)

Genetic variants may explain why patients who are infected with SARS-CoV-2 have either a relatively benign or an inappropriately aggressive response to an infectious insult. Medications may be more or less effective in that group of patients harboring genetic variants of a disease-related protein. To better understand this, whole genome sequencing and analysis will be performed on all study patients.

Eligibility criteria: Inclusion Criteria:

* Confirmed or highly suspected early stage severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), disease with clinical suspicion score \>6/20, not requiring hospitalization
* Age ≥18 years
* Willing to sign the informed consent form
* Willing to take study drug or placebo as directed for 21 days

Exclusion Criteria:

* Confirmed or highly suspected early stage severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), disease with clinical suspicion score \>6/20, requiring hospitalization
* Suspected or confirmed convalescent severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), within the prior 4 weeks
* Age \<18 years' old
* Inability to take medications orally
* Inability to provide written consent
* Known sensitivity/allergy to doxycycline or tetracyclines
* Current use of doxycycline for another indication
* Pregnancy
* A known diagnosis of myasthenia gravis
* History of Clostridium Difficile infection within past 12 months
* Sun sensitivity
* Individuals using medications which could lower doxycycline levels, including barbiturates, phenytoin, carbamazepine, warfarin
* Individuals using isotretinoin

Primary outcomes:
measure: Time Free of Either Hospitalization, Hypoxemia, ICU Admission or Death
timeFrame: 21 days
Secondary outcomes:
measure: NP SARS-CoV-2 PCR
timeFrame: 21 days
measure: SARS-CoV-2 Serum Quantitative Viral Load
timeFrame: 21 days
measure: SARS-CoV-2 IgM/IgG Antibodies
timeFrame: 21 days
measure: White Blood Cell Count (WBC)
timeFrame: 21 days
measure: Absolute Lymphocyte Count (ALC)
timeFrame: 21 days
measure: C-Reactive Protein (CRP)
timeFrame: 21 days
measure: N-Terminal Pro-B-Type Natriuretic Peptide (Pro-BNP)
timeFrame: 21 days
measure: High Sensitivity Troponin I (hsTnT)
timeFrame: 21 days
measure: Tumor Necrosis Factor Alpha (TNF-a)
timeFrame: 21 days
measure: IL-1
timeFrame: 21 days
measure: IL-1B
timeFrame: 21 days
measure: IL-6
timeFrame: 21 days
Other outcomes:
Locations:
city: Philadelphia
country: United States
facility: Temple University Hospital
state: Pennsylvania
Study officials:
affiliation: Temple University
name: Arthur M Feldman, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References: