louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03285009: Movement Patterns in Young Volleyball Athletes
Official title: Optimizing Body and Movement Specific Characteristics in Volleyball Players to Reduces Injuries in Young Athletes.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Injuries
Training
Athlete
Youth
Lead sponsor: Universitaire Ziekenhuizen KU Leuven
Sponsor class: OTHER
First posted: 2017-09-15
Enrollment: 14
Sex: ALL
Minimum age (years): 11
Maximum age (years): 13
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: This project is a consequence of the research chair project studying the same phenomenon in adult volleyball players. The project will make use of and be part of the routine medical screening that is taken by the young players of the first degree of the Leuven Volleyball School, Belgium. All young players must undergo a routine medical investigation and movement screening. This is obliged by the law. The current project will use these data. Outcome parameters will be used to advice the trainer staff of the school to adjust their training interventions. This is normal routine too as the involved medical department has been advising the school for many years. Players will be followed up for 6 weeks. After those 6 weeks, the movement screening will be repeated to evaluate the change in the different outcome parameters. This last screening is not part of a normal routine as players normally are investigated more in a subjective way. The medical team and school want to change that routine.

Data will be used to further improve training modalities and sports performance and reduce injury risk in these young athletes.


Eligibility criteria: Inclusion Criteria:

* All students from the first degree of the Volleyball school will participate
* Male and female athletes will be included
* Signing of an informed consent and assent form (for young kids) to use data for research
* Agreement given by the medical staff to use data and allowing the kids to be accepted by the school

Exclusion Criteria:

* When inclusion criteria are not met

Primary outcomes:
measure: Change of joint mobility
timeFrame: Difference between baseline and 6 weeks
measure: Change of strength
timeFrame: Difference between baseline and 6 weeks
measure: Change in balance score
timeFrame: Difference between baseline and 6 weeks
measure: Change in lower limb joint angles during a single leg drop vertical jump
timeFrame: Difference between baseline and 6 weeks
measure: Change in lumbopelvic stability score
timeFrame: Difference between baseline and 6 weeks
measure: Change in lower limb joint angles during a drop jump
timeFrame: Difference between baseline and 6 weeks
Secondary outcomes:
measure: Individualized web diagram of all outcome measurements
timeFrame: Baseline
measure: Number of injuries
timeFrame: Baseline information from medical investigation
Other outcomes:
Locations:
city: Leuven
country: Belgium
facility: UZ Leuven
Study officials:
affiliation: KU Leuven
name: Filip F Staes, prof
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03399409: Motivational Interviewing in Physiotherapy for Patients With Low Back Pain
Official title: Motivational Interviewing in Physiotherapy for Patients With Low Back Pain: Effects on Adherence to Exercises and on Levels of Incapacity and Pain
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Motivational Interviewing
Lead sponsor: Universidade do Porto
Sponsor class: OTHER
First posted: 2018-01-16
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study aims to evaluate the efficacy of motivational interviewing (MI) on adherence to exercises and on levels of pain and incapacity in patients who engage in physiotherapy for low back pain. Sixty patients attending a 15-day program of physiotherapy for low back pain were allocated to experimental (EG) and control groups (CG). A regular treatment of physiotherapy with at-home exercises is offered to all participants. On day seven, MI is applied to the EG. The CG receives an anti-inflammatory information program.


Eligibility criteria: Inclusion Criteria:

* Adults with low back pain receiving physiotherapy with home exercises

Exclusion Criteria:

* Adults receiving physiotherapy without home exercises or for conditions other than low back pain

Primary outcomes:
measure: Change in adherence to home exercises
timeFrame: Change from Baseline Performance of Exercises at 2 weeks
Secondary outcomes:
measure: Change in levels of pain
timeFrame: Change from Baseline Levels of Pain at 2 weeks
measure: Change in levels of incapacity
timeFrame: Change from Baseline Levels of Incapacity at 2 weeks
Other outcomes:
Locations:
Study officials:
affiliation: Universidade do Porto
name: Irene P carvalho, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01821885: Effectiveness of Spirometry as a Motivational Tool to Quit Smoking
Official title: Effectiveness of Spirometry and the Report of Spirometric Test Results by a Primary Care Physician on Smoking Cessation Rate in Adult Smokers: a Randomized Controlled Trial.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Smoking Cessation
COPD
Keywords: Spirometry
screening
smoking cessation
tobacco
COPD
Lead sponsor: Basque Health Service
Sponsor class: OTHER_GOV
First posted: 2013-04-01
Enrollment: 335
Sex: ALL
Minimum age (years): 40
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The aim of the study is to asses the efficacy of the spirometry and a minimal smoking cessation counselling intervention to quit smoking after a year in patients older than 40 years, smokers of more than 10 packs-year and without a chronic obstructive pulmonary disease (COPD) diagnosis.


Eligibility criteria: Inclusion Criteria:

- Active smokers over 40 years and more than 10 pack-years

Exclusion Criteria:

* Previous diagnosis of respiratory disease (asthma, COPD, interstitial lung disease) that cause alteration of spirometric pattern.
* Patients with limitations in performing spirometry
* Age greater than 80 years
* Institutionalized patients
* Patients with a life expectancy less than 1 year
* Spirometry in the past 2 years

Primary outcomes:
measure: The primary measure of results will be the differences in smoking cessation rates between intervention and control groups
timeFrame: 12 months after been conducted the intervention
Secondary outcomes:
measure: Reduce the number of cigarettes among those who continue smoking
timeFrame: 12 months after been conducted the intervention
measure: Increase smoking abstinence rates in patients with COPD
timeFrame: 12 months after been conducted the intervention
Other outcomes:
Locations:
city: Vitoria-Gasteiz
country: Spain
facility: Basque health service
state: Alava 45
Study officials:
affiliation: Osakidetza
name: Mª Isabel Irizar Aramburu
role: PRINCIPAL_INVESTIGATOR
References:
citation: Irizar-Aramburu MI, Martinez-Eizaguirre JM, Pacheco-Bravo P, Diaz-Atienza M, Aguirre-Arratibel I, Pena-Pena MI, Alba-Latorre M, Galparsoro-Goikoetxea M. Effectiveness of spirometry as a motivational tool for smoking cessation: a clinical trial, the ESPIMOAT study. BMC Fam Pract. 2013 Dec 5;14:185. doi: 10.1186/1471-2296-14-185.
Clinical trial NCT06872385: Profile of Brazilian Climacteric Women: the Brazilian Menopause Study
Official title: Profile of Brazilian Climacteric Women: the Brazilian Menopause Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Menopause
Keywords: menopause
hormone replacement therapy
epidemiology
knowledge
Lead sponsor: Faculdade de Medicina do ABC
Sponsor class: OTHER
First posted: 2025-03-12
Enrollment: 1500
Sex: FEMALE
Minimum age (years): 45
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Women aged between 45 and 65 years who accept to answer an online questionnaire in order to known their opinions on menopause and treatments for menopause, specially hormone therapy

Brief summary: Cross-sectional study with 1,500 women between 45 and 65 years old. Women participate by answering questionnaires prepared to get information about their perceptions and knowledge about menopause, hormone therapy and other treatments for menopause.

Detailed description: This is a cross-sectional study with 1,500 women between 45 and 65 years old. The subjects participate by answering online questionnaires prepared to get information about their perceptions and knowledge about menopause, hormone therapy and other treatments for menopause. The distribution of subjects respect the distribution of Brazilian population according to country regions and according to socioeconomic class, and taking into account the information of last official Brazilian demographic census.

Eligibility criteria: Inclusion Criteria:

* Women between 45 and 65 years of age
* Women able to participate in a questionnaire on a digital platform and who have a device allowing this access

Exclusion Criteria:

* Pregnant or lactating women

Primary outcomes:
measure: Answer to the questionnaire
timeFrame: Day 1
Secondary outcomes:
Other outcomes:
Locations:
city: Santo Andre
country: Brazil
facility: Faculdade de Medicina do ABC
state: SP
Study officials:
affiliation: Faculdade de Medicina do ABC
name: Luciano M Pompei
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00793585: A Controlled Study of Uric Acid on the Progression of IgA Nephropathy
Official title: A Prospective, Randomized Controlled Study of Uric Acid on the Progression of IgA Nephropathy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: IgA Nephropathy
Keywords: IgA nephropathy
Lead sponsor: Sun Yat-sen University
Sponsor class: OTHER
First posted: 2008-11-19
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This prospective, randomized controlled study will evaluate the effect of uric acid on the progression of IgA nephropathy.

Detailed description: It has been reported that hyperuricemia is a risk factor for progression of IgAN. This will be a prospective, randomized study. Eligible IgAN patients will be randomized into the treatment group and the control group. Patients in treatment group will receive allopurinol and usual therapy. Patients in control group will receive usual therapy with placebo. If with hypertension, add the CCB and the β-blocker. Fasting uric acid, serum creatinine, albumin, routine blood test, urine microscopy and dipstick, proteinuria of 24 hours and blood pressure will be measured every month. After followed-up for 6 months, the curative effect of Allopurinol on blood pressure, proteinuria and the progression of IgA nephropathy will be evaluated.

Eligibility criteria: Inclusion Criteria:

1. Subjects of either sex, more than 18 years old, the range of age is 18 to 70 year old.
2. Biopsy-proven IgA nephropathy.
3. Proteinuria between 0.15g/d and 3.0g/d; and serum albumin level\>3.5g/dl.
4. Serum creatinine \< 3 mg/dl.
5. Uric acid \> 6 mg//dl (360umol/dl) in female; Uric acid \>7mg/dl (420umol/dl ) in male.
6. No history of taking ACEI or ARB within 2 weeks.
7. Blood pressure \< 180/110 mmHg.
8. Subjects who agree to participate in the study and sign the informed consent.

Exclusion Criteria:

1. Patients who have received prednisone or immunosuppressive drugs within 2 months.
2. Patients who must take ACEI or ARB due to other diseases.
3. Patients who have the history of allergy to allopurinol.
4. Unwillingness to follow the study protocol.
5. Active gout within 4 weeks.
6. Pregnancy or unwillingness to use contraception.

Primary outcomes:
measure: Change in Renal Function as Measured With eGFR
timeFrame: baseline and 6 months
Secondary outcomes:
measure: The Longitudinal Change in Proteinuria and Blood Pressure(Including Changes in Antihypertensive Drugs Dosing).
timeFrame: baseline and 6 months
Other outcomes:
Locations:
city: GuangZhou
country: China
facility: The 1st Affiliated Hospital, Sun Yet-sen University
state: Guangdong
Study officials:
affiliation: 1st Affiliated Hospital, Sun Yat-Sen University
name: Xueqing Yu, M.D. & Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03506685: Effectiveness of Dry Needling and STM on Pain Management for ACLR
Official title: The Effectiveness of Dry Needling and Soft Tissue Mobilization in the Management of Pain Post ACL Reconstruction: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Pain and Anterior Cruciate Ligament Reconstruction
Keywords: dry needling
ACL reconstruction
knee ROM
pain management
opioid use
Lead sponsor: Keller Army Community Hospital
Sponsor class: FED
First posted: 2018-04-24
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Intervention model description: 2x5 mixed model anova
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine if dry needling (DN) and soft tissue mobilization (STM) is superior to standard treatment protocol for affecting pain, pain medication usage and measurements of range of motion (ROM) after ACL reconstruction surgery compared to a standard treatment protocol. Measurements of pain, pain medication usage, lower extremity functional scale (LEFS) and ROM will be taken day 2 post op and 1 week, 2 weeks, 3 weeks, and 4 weeks post op. It is hypothesized that the inclusion of DN and STM will acutely decrease the demand for pain medication and improve objective measurements when compared to a standard treatment protocol. Findings will potentially lead to insights as to the benefit of applying these interventions to help decrease the demand for pain medication post-surgery.


Eligibility criteria: Inclusion Criteria:

* Age 18-40 Department of Defense( DOD) beneficiaries (17 if Cadet)
* Scheduled for ACL Reconstruction Surgery

Exclusion Criteria:

* Self-Reported Pregnancy
* History of blood borne pathogens/infectious disease/active infection/metal allergy
* Bleeding disorders or currently taking anti-coagulant medications
* Participants who are not fluent in English

Primary outcomes:
measure: Numerical pain rating scale
timeFrame: change from baseline, 2 days post-op, 1 week, 2 week, 3 week, 4 week
Secondary outcomes:
measure: Lower extremity functional scale
timeFrame: change from baseline, 2 days post-op, 1 week, 2 week, 3 week, 4 week
measure: Global rate of change
timeFrame: change from baseline, 2 days post-op, 1 week, 2 week, 3 week, 4 week
measure: knee range of motion
timeFrame: change from baseline, 2 days post-op, 1 week, 2 week, 3 week, 4 week
Other outcomes:
Locations:
city: West Point
country: United States
facility: Keller Army Community Hospital
state: New York
Study officials:
References:
Clinical trial NCT03121885: Human Metabolic Dynamics at Rest and During Aerobic Exercise Under Normobaric Normoxic and Moderate Hypoxic Conditions
Official title: MetaboDyn- Liquid-liquid Extraction of Single Drops of Whole Capillary Blood as a Reliable Method of Measuring Metabolic Effects of Exercise: A Pilot Study.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Energy Metabolism
Hypoxia
Metabolism and Nutrition Disorder
Lead sponsor: Charite University, Berlin, Germany
Sponsor class: OTHER
Collaborators: name: Max Delbrück Center for Molecular Medicine in the Helmholtz Association (MDC) Berlin
First posted: 2017-04-20
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: The aim is to define in detail metabolic pathways at rest and during aerobic exercise in normal and healthy men and women under normobaric normoxic and moderate hypoxic conditions, using metabolomics technologies based on minimally invasive sampling relying on gas chromatography and mass spectrometry.


Eligibility criteria: Inclusion criteria:

* approval and written, informed consent
* healthy adults of varying fitness levels (age \>18 years to 75 years)

Exclusion criteria:

* chronic illness requiring any medication
* pregnancy
* limitations regarding functioning in the hypoxic chamber
* inability to follow simple instructions
* relevant or severe abnormalities in medical history, physical examination, ECG routine laboratory parameters from blood and urine

Primary outcomes:
measure: Coefficient of variation of relative quantities of metabolites and physiological parameters related to its dynamic during exercise under normoxic and hypoxic conditions, using GC-MS.
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Berlin
country: Germany
facility: Charité University Experimental & Clinical Research Center
Study officials:
References:
Clinical trial NCT03081585: Food Reward Processing in the Human Brain
Official title: Integration of Homeostatic Signaling and Food Reward Processing in the Human Brain
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Healthy
Keywords: fmri
neuronal reward processing
hormonal satiety signalling
fasting
Lead sponsor: University of Heidelberg Medical Center
Sponsor class: OTHER
First posted: 2017-03-16
Enrollment: 23
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Healthy normal weight female participants

Brief summary: The aim of this study is to investigate the influence of different metabolic states and hormonal satiety signalling on responses in neural reward networks.

Detailed description: Given the rapid development of obesity world-wide, a better understanding of the interaction between the encoding of food reward in mesocorticolimbic reward pathways and homeostatic energy regulation is of paramount importance for the development of new treatment strategies. Healthy participants will undergo functional magnetic resonance imaging while performing a task distinguishing between the anticipation and the receipt of either food or monetary reward. Every participant will be scanned twice in a counterbalanced fashion, both during a state of hunger (after 24-hours fasting) and satiety. Blood samples will be collected to assess hormonal satiety signalling. We hope to provide new insights into the neurobiological underpinnings of motivational processing and hedonic evaluation of food reward.

Eligibility criteria: Inclusion Criteria:

* BMI \<25 kg/m² and \>18.5 kg/m²
* no lifetime or current medical illness that could potentially affect appetite or body weight
* right-handedness
* normal or corrected-to-normal vision

Exclusion Criteria:

* history of head injury or surgery
* history of neurological disorder
* severe psychiatric disorder (psychosis, bipolar disorder, substance abuse)
* smoking
* borderline personality disorder
* current psychotropic medication
* inability to undergo fMRI scanning (e.g. metallic implants, claustrophobia, Pacemakers)
* pregnancy

Primary outcomes:
measure: Experimental fMRI task (incentive delay task)
timeFrame: 22 min.
measure: Resting state brain activity using functional magnetic resonance imaging
timeFrame: 5 min.
Secondary outcomes:
measure: Analysis of hormonal satiety signaling
timeFrame: 30 min. before scanning
measure: Self-report questionnaire regarding eating behavior (Dutch Eating Behavior Questionnaire)
timeFrame: 30 min.
Other outcomes:
Locations:
Study officials:
affiliation: University Hospital Heidelberg
name: Joe Simon, Dr. Dipl. Psych.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Simon JJ, Wetzel A, Sinno MH, Skunde M, Bendszus M, Preissl H, Enck P, Herzog W, Friederich HC. Integration of homeostatic signaling and food reward processing in the human brain. JCI Insight. 2017 Aug 3;2(15):e92970. doi: 10.1172/jci.insight.92970. eCollection 2017 Aug 3.
Clinical trial NCT06799585: Dental Loupes in Pediatric Dentistry Practice Affect Ergonomic Posture
Official title: Does Wearing Dental Loupes in Pediatric Dentistry Practice Affect Ergonomic Posture?
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Ergonomics
Musculoskeletal Diseases
Pediatric Dentistry
Lead sponsor: Recep Tayyip Erdogan University Training and Research Hospital
Sponsor class: OTHER
First posted: 2025-01-29
Enrollment: 46
Sex: ALL
Minimum age (years): 6
Maximum age (years): 8
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Pediatric population

Brief summary: This study aims to investigate the effect of wearing DL on the working posture of pediatric dentists.

Detailed description: In pulpotomy procedures performed with DL in 23 patients and without DL in 23 patients, photographs will taken at a total of 3 times in each patient: at the beginning of the procedure, 15th and 30th minutes. The working postures of the clinicians will analyzed using the Modified-Dental Operator Posture Assessment Instrument (M-DOPAI) method through these photographs.

Eligibility criteria: Inclusion Criteria:

* indication for pulpotomy in the mandibular right second primary molar,
* 3 (positive)- 4 (definitely positive) according to the Frankl Behavior Scale,
* parents volunteered to participate in the study and signed the informed consent form,
* did not have any systemic disease or disability.

Exclusion Criteria:

* contraindication for pulpotomy in the mandibular right second primary molar
* 2 (negative)- 1 (definitely negative) according to the Frankl Behavior Scale

Primary outcomes:
measure: The effect of wearing DL on the working posture with Modified-Dental Operator Posture Assessment Instrument (M-DOPAI)
timeFrame: 3 month
Secondary outcomes:
Other outcomes:
Locations:
city: Lütfen Seçiniz
country: Turkey
facility: Recep Tayyip Erdoğan University Faculty of Dentistry
state: Ri̇ze
Study officials:
References: