Clinical trial NCT00633893: Efficacy and Safety Study of Apixaban for Extended Treatment of Deep Vein Thrombosis or Pulmonary Embolism
Official title: A Safety and Efficacy Trial Evaluating the Use of Apixaban for the Extended Treatment of Deep Vein Thrombosis and Pulmonary Embolism
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Venous Thrombosis
Lead sponsor: Bristol-Myers Squibb
Sponsor class: INDUSTRY
Collaborators: name: Pfizer
First posted: 2008-03-12
Enrollment: 2711
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose is to evaluate the effects of an investigational blood thinner, apixaban, in preventing venous thromboembolic (VTE) recurrence or death in patients who have completed their intended treatment for deep vein thrombosis (DVT) or pulmonary embolism (PE)


Eligibility criteria: Inclusion Criteria:

* Men and women ≥ 18 years of age;
* Clinical diagnosis of Deep Vein Thrombosis (DVT) or Pulmonary Embolism (PE);
* Anticoagulant treatment completed
* No recurrence of Venous Thromboembolism (VTE)

Exclusion Criteria:

* Subjects with indications for long-term treatment with a vitamin K antagonist
* Active bleeding or high risk for serious bleeding
* Short life expectancy
* Uncontrolled high blood pressure
* Impaired kidney or liver function

Primary outcomes:
measure: Adjudicated Composite of Symptomatic, Recurrent Venous Thromboembolism (VTE) or All-Cause Death During the Intended Treatment Period - Randomized Population With Imputation
timeFrame: Day 1 up to 12 Months
measure: Adjudicated Composite of Symptomatic, Recurrent Venous Thromboembolism (VTE) or All-Cause Death During the Intended Treatment Period - Randomized Population Without Imputation
timeFrame: Day 1 up to 12 months
Secondary outcomes:
measure: Adjudicated Composite of Recurrent, Symptomatic Venous Thromboembolism (VTE) or VTE-related Death During the Intended Treatment Period - Randomized Population With Imputation
timeFrame: Day 1 up to 12 Months
measure: Adjudicated Composite of Recurrent, Symptomatic Venous Thromboembolism (VTE) or Cardio Vascular (CV) -Related Death During the Intended Treatment Period - Randomized Population With Imputation
timeFrame: Day 1 up to 12 Months
measure: Adjudicated Nonfatal Deep Vein Thrombosis (DVT) During the Intended Treatment Period - Randomized Population With Imputation
timeFrame: Day 1 up to 12 Months
measure: Adjudicated Nonfatal Pulmonary Embolism (PE) During the Intended Treatment Period - Randomized Population With Imputation
timeFrame: Day 1 up to 12 Months
measure: Adjudicated Venous Thromboembolism (VTE) - Related Death During the Intended Treatment Period - Randomized Population With Imputation
timeFrame: Day 1 up to 12 Months
measure: Adjudicated Cardiovascular (CV)-Related Death During the Intended Treatment Period - Randomized Population With Imputation
timeFrame: Day 1 up to 12 Months
measure: Adjudicated All-Cause Death During the Intended Treatment Period - Randomized Population With Imputation
timeFrame: Day 1 up to 12 Months
measure: Number of Participants With an Adjudicated Symptomatic Nonfatal Venous Thromboembolism (VTE) Recurrence or Death (All Cause) During the Intended Treatment Period - Randomized Participants Without Imputation
timeFrame: Day 1 up to 12 Months
measure: Adjudicated Major Bleeding During the Treatment Period - Treated Population
timeFrame: Day 1 up to 12 Months
measure: Adjudicated Composite of Major/Clinically Relevant Non-major Bleeding During the Treatment Period - Treated Participants
timeFrame: Day 1 up to 12 Months
measure: Adjudicated Clinically Relevant Non-major Bleeding During the Treatment Period - Treated Participants
timeFrame: Day 1 up to 12 months
measure: Adjudicated Clinically Relevant Minor Bleeding During the Treatment Period - Treated Participants
timeFrame: Day 1 up to 12 months
measure: Adjudicated Total Bleeding During the Treatment Period - Treated Participants
timeFrame: Day 1 up to 12 months
measure: Adjudicated Composite of Recurrent, Symptomatic Venous Thromboembolism (VTE) or Venous Thromboembolism-related Death During the Intended Treatment Period - Randomized Population Without Imputation
timeFrame: Day 1 up to 12 Months
measure: Adjudicated Composite of Recurrent, Symptomatic Venous Thromboembolism (VTE) or Cardio Vascular (CV) - Related Death During the Intended Treatment Period - Randomized Population Without Imputation
timeFrame: Day 1 up to 12 Months
measure: Adjudicated Nonfatal Deep Vein Thrombosis (DVT) During the Intended Treatment Period - Randomized Population Without Imputation
timeFrame: Day 1 up to 12 Months
measure: Adjudicated Nonfatal Pulmonary Embolism (PE) During the Intended Treatment Period - Randomized Population Without Imputation
timeFrame: Day 1 up to 12 Months
measure: Adjudicated Venous Thromboembolism (VTE)- Related Death During the Intended Treatment Period - Randomized Population Without Imputation
timeFrame: Day 1 up to 12 Months
measure: Adjudicated Cardio Vascular (CV)-Related Death During the Intended Treatment Period - Randomized Population Without Imputation
timeFrame: Day 1 up to 12 Months
measure: Adjudicated All-Cause Death During the Intended Treatment Period - Randomized Population Without Imputation
timeFrame: Day 1 up to 12 Months
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: Alabama Clinical Therapeutics, Llc
state: Alabama
city: Phoenix
country: United States
facility: Cardiovascular Consultants, Ltd.
state: Arizona
city: Tempe
country: United States
facility: Robert J. Bloomberg, Md, Pc
state: Arizona
city: Fort Smith
country: United States
facility: Fort Smith Lung Center
state: Arkansas
city: Banning
country: United States
facility: Beaver Medical Group
state: California
city: La Jolla
country: United States
facility: Scripps Clinic/Scripps Health And Green Hospital
state: California
city: Los Angeles
country: United States
facility: Healthcare Partners Medical Group
state: California
city: Mission Viejo
country: United States
facility: Mission Internal Medical Group
state: California
city: Palm Springs
country: United States
facility: Desert Med Grp Inc, Dba Desert Oasis Healthcare Med Group
state: California
city: Pomona
country: United States
facility: Indus Clinical Research Institute, Inc.
state: California
city: San Francisco
country: United States
facility: Kaiser Permanente Medical Center
state: California
city: Stanford
country: United States
facility: Stanford University Medical Center
state: California
city: Torrance
country: United States
facility: Harbor Ucla Medical Center
state: California
city: Vista
country: United States
facility: Progressive Clinical Research
state: California
city: Aurora
country: United States
facility: Rocky Mountain Internal Medicine
state: Colorado
city: Golden
country: United States
facility: New West Physicians
state: Colorado
city: Newark
country: United States
facility: Alfieri Cardiology
state: Delaware
city: Bay Pines
country: United States
facility: Bay Pines Va Healthcare Systems
state: Florida
city: Clearwater
country: United States
facility: Research Alliance, Inc.
state: Florida
city: Clearwater
country: United States
facility: St. Francis Sleep Allergy & Lung Institute
state: Florida
city: Fort Lauderdale
country: United States
facility: Berma Research Group
state: Florida
city: Hollywood
country: United States
facility: Healthworx
state: Florida
city: Loxahatchee
country: United States
facility: Hematology Oncology Associates
state: Florida
city: Miami
country: United States
facility: South Miami Heart Center
state: Florida
city: Naples
country: United States
facility: Physicians Regional Medical Group
state: Florida
city: Plantation
country: United States
facility: Richard A. Mclean M.D., P.A.
state: Florida
city: Tampa
country: United States
facility: Tampa Clinical Research
state: Florida
city: Vero Beach
country: United States
facility: Primary Care Of The Treasure Coast, Inc.
state: Florida
city: Weston
country: United States
facility: Cleveland Clinic Florida
state: Florida
city: Austell
country: United States
facility: Vascular Surgical Associates, Pc
state: Georgia
city: Decatur
country: United States
facility: Atlanta Institute For Medical Research, Inc
state: Georgia
city: Lawrenceville
country: United States
facility: Gwinnett Biomedical Research
state: Georgia
city: Boise
country: United States
facility: Boise Orthopedic Clinic
state: Idaho
city: Nampa
country: United States
facility: Saltzer Medical Group
state: Idaho
city: Carmel
country: United States
facility: Infectious Disease Of Indiana Psc
state: Indiana
city: New Albany
country: United States
facility: Office Of:Eugene C. Fletcher, Md
state: Indiana
city: Windsor Heights
country: United States
facility: Heartland Vascular Medicine And Surgery
state: Iowa
city: Hazard
country: United States
facility: Kentucky Lung Clinic
state: Kentucky
city: Owensboro
country: United States
facility: Owensboro Heart & Vascular
state: Kentucky
city: Rockport
country: United States
facility: Pen Bay Medical Center
state: Maine
city: Annapolis
country: United States
facility: Anne Arundel Health System Research Institute, Inc.
state: Maryland
city: Hyannis
country: United States
facility: Cape Cod Research Institute
state: Massachusetts
city: Detroit
country: United States
facility: Henry Ford Hospital
state: Michigan
city: Royal Oak
country: United States
facility: William Beaumont Hospital
state: Michigan
city: Kansas City
country: United States
facility: Veterans Affairs Medical Center
state: Missouri
city: Butte
country: United States
facility: Mercury Street Medical Group, Pllc
state: Montana
city: Great Falls
country: United States
facility: Great Falls Clinic, Llp
state: Montana
city: Grand Island
country: United States
facility: Internal Medical Associates Of Grand Island, P.C
state: Nebraska
city: Omaha
country: United States
facility: Creighton University Medical Center
state: Nebraska
city: Buffalo
country: United States
facility: Kaleida Health System
state: New York
city: Goshen
country: United States
facility: Goshen Medical Associates
state: New York
city: Liverpool
country: United States
facility: Sjh Cardiology Associates
state: New York
city: Staten Island
country: United States
facility: Richmond University Medical Center
state: New York
city: Valhalla
country: United States
facility: New York Medical College
state: New York
city: Durham
country: United States
facility: Thomas L. Ortel, Md, Phd
state: North Carolina
city: Fayetteville
country: United States
facility: Valley Internal Medicine
state: North Carolina
city: Raleigh
country: United States
facility: Rex Healthcare
state: North Carolina
city: Statesville
country: United States
facility: Piedmont Healthcare/Research
state: North Carolina
city: Whiteville
country: United States
facility: Whiteville Medical Associates, P.A.
state: North Carolina
city: Wilmington
country: United States
facility: Wilmington Medical Research
state: North Carolina
city: Akron
country: United States
facility: Akron General Medical Center
state: Ohio
city: Canal Fulton
country: United States
facility: Community Health Care, Inc.
state: Ohio
city: Centerville
country: United States
facility: Valley Medical Research
state: Ohio
city: Columbus
country: United States
facility: Ohio State University Medical Center
state: Ohio
city: Columbus
country: United States
facility: Remington Davis Inc.
state: Ohio
city: Toledo
country: United States
facility: Jobst Vascular Center At The Toledo Hospital
state: Ohio
city: Oklahoma City
country: United States
facility: Cor Clinical Research, Llc
state: Oklahoma
city: Phoenixville
country: United States
facility: Pma Medical Specialists
state: Pennsylvania
city: Providence
country: United States
facility: Rhode Island Hospital
state: Rhode Island
city: Charleston
country: United States
facility: Charleston Hematology Oncology Associates, Pa
state: South Carolina
city: Greenville
country: United States
facility: Greenville Hospital System
state: South Carolina
city: Irmo
country: United States
facility: Three Rivers Medical Associates, Pa
state: South Carolina
city: Murrells Inlet
country: United States
facility: Clinical Research Authority, Llc
state: South Carolina
city: Summerville
country: United States
facility: Palmetto Clinical Research
state: South Carolina
city: Bristol
country: United States
facility: Holston Medical Group
state: Tennessee
city: Kingsport
country: United States
facility: Holston Medical Group
state: Tennessee
city: Amarillo
country: United States
facility: Amarillo Heart Clinical Research Institute Inc.
state: Texas
city: Corsicana
country: United States
facility: Corsicana Medical Research
state: Texas
city: Houston
country: United States
facility: Ankur Doshi, Md
state: Texas
city: Tomball
country: United States
facility: Northwest Heart Center
state: Texas
city: Layton
country: United States
facility: Tanner Clinic
state: Utah
city: Salt Lake City
country: United States
facility: University Of Utah Hospital
state: Utah
city: Charlottesville
country: United States
facility: University Of Virginia Health System
state: Virginia
city: Norfolk
country: United States
facility: Sentara York Clinical Research
state: Virginia
city: Bellevue
country: United States
facility: Lake Washington Vascular, Pllc
state: Washington
city: Tacoma
country: United States
facility: Franciscan Research Center
state: Washington
city: Menomonee Falls
country: United States
facility: Medical Assoicates Inc.
state: Wisconsin
city: Capital Federal
country: Argentina
facility: Local Institution
state: Buenos Aires
city: Ciudad Autonoma De Buenos Aire
country: Argentina
facility: Local Institution
state: Buenos Aires
city: Ciudad Autonoma De Buenos Aire
country: Argentina
facility: Local Institution
state: Buenos Aires
city: Ciudad Autonoma De Buenos Aire
country: Argentina
facility: Local Institution
state: Buenos Aires
city: Ciudad De Buenos Aires
country: Argentina
facility: Local Institution
state: Buenos Aires
city: Ciudad De Buenos Aires
country: Argentina
facility: Local Institution
state: Buenos Aires
city: Coronel Suarez
country: Argentina
facility: Local Institution
state: Buenos Aires
city: La Plata
country: Argentina
facility: Local Institution
state: Buenos Aires
city: La Plata
country: Argentina
facility: Local Institution
state: Buenos Aires
city: Mar Del Plata
country: Argentina
facility: Local Institution
state: Buenos Aires
city: San Martin
country: Argentina
facility: Local Institution
state: Buenos Aires
city: Rosario
country: Argentina
facility: Local Institution
state: Santa Fe
city: Rosario
country: Argentina
facility: Local Institution
state: Santa Fe
city: Rosario
country: Argentina
facility: Local Institution
state: Santa Fe
city: Buenos Aires
country: Argentina
facility: Local Institution
city: Buenos Aires
country: Argentina
facility: Local Institution
city: Buenos Aires
country: Argentina
facility: Local Institution
city: Cordoba
country: Argentina
facility: Local Institution
city: Cordoba
country: Argentina
facility: Local Institution
city: Corrientes
country: Argentina
facility: Local Institution
city: Garran
country: Australia
facility: Local Institution
state: Australian Capital Territory
city: Kogarah
country: Australia
facility: Local Institution
state: New South Wales
city: Lismore
country: Australia
facility: Local Institution
state: New South Wales
city: St Leonards
country: Australia
facility: Local Institution
state: New South Wales
city: Herston
country: Australia
facility: Local Institution
state: Queensland
city: Kippa Ring
country: Australia
facility: Local Institution
state: Queensland
city: Woolloongabba
country: Australia
facility: Local Institution
state: Queensland
city: Adelaide
country: Australia
facility: Local Institution
state: South Australia
city: Bedford Park
country: Australia
facility: Local Institution
state: South Australia
city: Launceston
country: Australia
facility: Local Institution
state: Tasmania
city: Box Hill
country: Australia
facility: Local Institution
state: Victoria
city: Clayton
country: Australia
facility: Local Institution
state: Victoria
city: Footscray
country: Australia
facility: Local Institution
state: Victoria
city: Parkville
country: Australia
facility: Local Institution
state: Victoria
city: Richmond
country: Australia
facility: Local Institution
state: Victoria
city: Ringwood East
country: Australia
facility: Local Institution
state: Victoria
city: Windsor
country: Australia
facility: Local Institution
state: Victoria
city: Perth
country: Australia
facility: Local Institution
state: Western Australia
city: Graz
country: Austria
facility: Local Institution
city: Innsbruck
country: Austria
facility: Local Institution
city: Vienna
country: Austria
facility: Local Institution
city: Vienna
country: Austria
facility: Local Institution
city: Wien
country: Austria
facility: Local Institution
city: Wien
country: Austria
facility: Local Institution
city: Salvador
country: Brazil
facility: Local Institution
state: Bahia
city: Brasilia
country: Brazil
facility: Local Institution
state: Distrito Federal
city: Belo Horizonte - Mg
country: Brazil
facility: Local Institution
state: Minas Gerais
city: Belo Horizonte - Mg
country: Brazil
facility: Local Institution
state: Minas Gerais
city: Curitiba
country: Brazil
facility: Local Institution
state: Parana
city: Curitiba
country: Brazil
facility: Local Institution
state: Parana
city: Curitiba
country: Brazil
facility: Local Institution
state: Parana
city: Curitiba
country: Brazil
facility: Local Institution
state: Parana
city: Rio Janeiro
country: Brazil
facility: Local Institution
state: Rio De Janeiro
city: Port Alegre
country: Brazil
facility: Local Institution
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Local Institution
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Local Institution
state: Rio Grande Do Sul
city: Porto Alegre
country: Brazil
facility: Local Institution
state: Rio Grande Do Sul
city: Botucatu
country: Brazil
facility: Local Institution
state: Sao Paulo
city: Campinas
country: Brazil
facility: Local Institution
state: Sao Paulo
city: Santo Andre - Sp
country: Brazil
facility: Local Institution
state: Sao Paulo
city: Sao Jose Do Rio Preto
country: Brazil
facility: Local Institution
state: Sao Paulo
city: Sao Jose Do Rio Preto
country: Brazil
facility: Local Institution
state: Sao Paulo
city: Rio De Janeiro
country: Brazil
facility: Local Institution
city: Sao Paulo
country: Brazil
facility: Local Institution
city: Sao Paulo
country: Brazil
facility: Local Institution
city: Sao Paulo
country: Brazil
facility: Local Institution
city: Sao Paulo
country: Brazil
facility: Local Institution
city: Edmonton
country: Canada
facility: Local Institution
state: Alberta
city: Edmonton
country: Canada
facility: Local Institution
state: Alberta
city: Edmonton
country: Canada
facility: Local Institution
state: Alberta
city: Kelowna
country: Canada
facility: Local Institution
state: British Columbia
city: Victoria
country: Canada
facility: Local Institution
state: British Columbia
city: Hamilton
country: Canada
facility: Local Institution
state: Ontario
city: Hamilton
country: Canada
facility: Local Institution
state: Ontario
city: Toronto
country: Canada
facility: Local Institution
state: Ontario
city: Waterloo
country: Canada
facility: Local Institution
state: Ontario
city: Windsor
country: Canada
facility: Local Institution
state: Ontario
city: Montreal
country: Canada
facility: Local Institution
state: Quebec
city: Montreal
country: Canada
facility: Local Institution
state: Quebec
city: Montreal
country: Canada
facility: Local Institution
state: Quebec
city: Pointe- Claire
country: Canada
facility: Local Institution
state: Quebec
city: St. Jerome
country: Canada
facility: Local Institution
state: Quebec
city: Quebec
country: Canada
facility: Local Institution
city: Temuco
country: Chile
facility: Local Institution
state: Araucania
city: Punta Arenas
country: Chile
facility: Local Institution
state: Magallanes Antartica
city: Independencia
country: Chile
facility: Local Institution
state: Metropolitana
city: Santiago
country: Chile
facility: Local Institution
state: Metropolitana
city: Santiago
country: Chile
facility: Local Institution
state: Metropolitana
city: Santiago
country: Chile
facility: Local Institution
state: Metropolitana
city: Santiago
country: Chile
facility: Local Institution
state: Metropolitana
city: Vina Del Mar
country: Chile
facility: Local Institution
state: Valparaiso
city: Kladno
country: Czech Republic
facility: Local Institution
city: Litomysl
country: Czech Republic
facility: Local Institution
city: Mestec Kralove
country: Czech Republic
facility: Local Institution
city: Ostrava Vitkovice
country: Czech Republic
facility: Local Institution
city: Plzen
country: Czech Republic
facility: Local Institution
city: Praha 13
country: Czech Republic
facility: Local Institution
city: Praha 1
country: Czech Republic
facility: Local Institution
city: Praha 1
country: Czech Republic
facility: Local Institution
city: Praha 2
country: Czech Republic
facility: Local Institution
city: Praha 2
country: Czech Republic
facility: Local Institution
city: Praha 2
country: Czech Republic
facility: Local Institution
city: Praha 4
country: Czech Republic
facility: Local Institution
city: Usti Nad Orlici
country: Czech Republic
facility: Local Institution
city: Arhus C
country: Denmark
facility: Local Institution
city: Braedstrup
country: Denmark
facility: Local Institution
city: Esbjerg
country: Denmark
facility: Local Institution
city: Frederiksberg
country: Denmark
facility: Local Institution
city: Hellerup
country: Denmark
facility: Local Institution
city: Herning
country: Denmark
facility: Local Institution
city: Hilleroed
country: Denmark
facility: Local Institution
city: Naestved
country: Denmark
facility: Local Institution
city: Silkeborg
country: Denmark
facility: Local Institution
city: Arras
country: France
facility: Local Institution
city: Besancon
country: France
facility: Local Institution
city: Brest Cedex
country: France
facility: Local Institution
city: Clamart
country: France
facility: Local Institution
city: Clermont-Ferrand Cedex 01
country: France
facility: Local Institution
city: Dijon
country: France
facility: Local Institution
city: Grenoble
country: France
facility: Local Institution
city: Le Kremlin-Bicetre
country: France
facility: Local Institution
city: Lille Cedex
country: France
facility: Local Institution
city: Limoges Cedex
country: France
facility: Local Institution
city: Lyon Cedex 03
country: France
facility: Local Institution
city: Nantes
country: France
facility: Local Institution
city: Saint-Priest En Jarez
country: France
facility: Local Institution
city: Toulouse Cedex 9
country: France
facility: Local Institution
city: Vernon
country: France
facility: Local Institution
city: Berlin
country: Germany
facility: Local Institution
city: Berlin
country: Germany
facility: Local Institution
city: Berlin
country: Germany
facility: Local Institution
city: Bochum
country: Germany
facility: Local Institution
city: Bonn
country: Germany
facility: Local Institution
city: Cologne
country: Germany
facility: Local Institution
city: Dortmund
country: Germany
facility: Local Institution
city: Dresden
country: Germany
facility: Local Institution
city: Dresden
country: Germany
facility: Local Institution
city: Erfurt
country: Germany
facility: Local Institution
city: Frankfurt
country: Germany
facility: Local Institution
city: Gottingen
country: Germany
facility: Local Institution
city: Karlsbad
country: Germany
facility: Local Institution
city: Krefeld
country: Germany
facility: Local Institution
city: Ludwigshafen
country: Germany
facility: Local Institution
city: Mannheim
country: Germany
facility: Local Institution
city: Mannheim
country: Germany
facility: Local Institution
city: Mannheim
country: Germany
facility: Local Institution
city: Munchen
country: Germany
facility: Local Institution
city: Munich
country: Germany
facility: Local Institution
city: Hong Kong
country: Hong Kong
facility: Local Institution
city: Shatin, N.T
country: Hong Kong
facility: Local Institution
city: Hyderabad
country: India
facility: Local Institution
state: Andhra Pradesh
city: Hyderabad
country: India
facility: Local Institution
state: Andhra Pradesh
city: Ahmedabad
country: India
facility: Local Institution
state: Gujarat
city: Gurgaon
country: India
facility: Local Institution
state: Haryana
city: Bangalore
country: India
facility: Local Institution
state: Karnataka
city: Bengaluru
country: India
facility: Local Institution
state: Karnataka
city: Kochi
country: India
facility: Local Institution
state: Kerala
city: Pune
country: India
facility: Local Institution
state: Maharashtra
city: Mohali
country: India
facility: Local Institution
state: Punjab
city: Ludhiana
country: India
facility: Local Institution
state: Tagore Nagar
city: Chennai
country: India
facility: Local Institution
state: Tamil Nadu
city: Ahmedabad
country: India
facility: Local Institution
city: Bangalore, Karnataka
country: India
facility: Local Institution
city: Bangalore
country: India
facility: Local Institution
city: Chennai
country: India
facility: Local Institution
city: Chennai
country: India
facility: Local Institution
city: New Dehli
country: India
facility: Local Institution
city: Afula
country: Israel
facility: Local Institution
city: Givataim
country: Israel
facility: Local Institution
city: Hadera
country: Israel
facility: Local Institution
city: Haifa
country: Israel
facility: Local Institution
city: Haifa
country: Israel
facility: Local Institution
city: Holon
country: Israel
facility: Local Institution
city: Jerusalem
country: Israel
facility: Local Institution
city: Kfar Saba
country: Israel
facility: Local Institution
city: Kiryat Hadassah
country: Israel
facility: Local Institution
city: Nahariya
country: Israel
facility: Local Institution
city: Petach-Tikva
country: Israel
facility: Local Institution
city: Safed
country: Israel
facility: Local Institution
city: Tel Aviv
country: Israel
facility: Local Institution
city: Tel Hashomer
country: Israel
facility: Local Institution
city: Bollate
country: Italy
facility: Local Institution
city: Bologna
country: Italy
facility: Local Institution
city: Chieti Scalo
country: Italy
facility: Local Institution
city: Cosenza
country: Italy
facility: Local Institution
city: Ferrara
country: Italy
facility: Local Institution
city: Firenze
country: Italy
facility: Local Institution
city: Genova
country: Italy
facility: Local Institution
city: Milano
country: Italy
facility: Local Institution
city: Padova
country: Italy
facility: Local Institution
city: Palermo
country: Italy
facility: Local Institution
city: Pavia
country: Italy
facility: Local Institution
city: Perugia
country: Italy
facility: Local Institution
city: Piacenza
country: Italy
facility: Local Institution
city: Pisa
country: Italy
facility: Local Institution
city: Roma
country: Italy
facility: Local Institution
city: Rozzano (Mi)
country: Italy
facility: Local Institution
city: San Daniele Del Friuli (Ud)
country: Italy
facility: Local Institution
city: Udine
country: Italy
facility: Local Institution
city: Venezia
country: Italy
facility: Local Institution
city: Vicenza
country: Italy
facility: Local Institution
city: Vittorio Veneto (Tv)
country: Italy
facility: Local Institution
city: Busan
country: Korea, Republic of
facility: Local Institution
city: Jongno-Gu
country: Korea, Republic of
facility: Local Institution
city: Seoul
country: Korea, Republic of
facility: Local Institution
city: Seoul
country: Korea, Republic of
facility: Local Institution
city: Seoul
country: Korea, Republic of
facility: Local Institution
city: Seoul
country: Korea, Republic of
facility: Local Institution
city: Tijuana
country: Mexico
facility: Local Institution
state: Baja California
city: Mexico
country: Mexico
facility: Local Institution
state: Distrito Federal
city: Leon
country: Mexico
facility: Local Institution
state: Guanajuato
city: Guadalajara
country: Mexico
facility: Local Institution
state: Jalisco
city: Guadalajara
country: Mexico
facility: Local Institution
state: Jalisco
city: Guadalajara
country: Mexico
facility: Local Institution
state: Jalisco
city: Zapopan
country: Mexico
facility: Local Institution
state: Jalisco
city: Monterrey
country: Mexico
facility: Local Institution
state: Nuevo Leon
city: Monterrey
country: Mexico
facility: Local Institution
state: Nuevo Leon
city: Culiacan
country: Mexico
facility: Local Institution
state: Sinaloa
city: Culiacan
country: Mexico
facility: Local Institution
state: Sinaloa
city: Xalapa
country: Mexico
facility: Local Institution
state: Veracruz
city: Aguascalientes
country: Mexico
facility: Local Institution
city: Chihuahua
country: Mexico
facility: Local Institution
city: Durango
country: Mexico
facility: Local Institution
city: Puebla
country: Mexico
facility: Local Institution
city: Queretaro
country: Mexico
facility: Local Institution
city: San Luis Potosi
country: Mexico
facility: Local Institution
city: San Luis Potosi
country: Mexico
facility: Local Institution
city: Alesund
country: Norway
facility: Local Institution
city: Fredrikstad
country: Norway
facility: Local Institution
city: Gjettum
country: Norway
facility: Local Institution
city: Gjovik
country: Norway
facility: Local Institution
city: Hamar
country: Norway
facility: Local Institution
city: Oslo
country: Norway
facility: Local Institution
city: Cavite
country: Philippines
facility: Local Institution
city: Davao City
country: Philippines
facility: Local Institution
city: Pasig City
country: Philippines
facility: Local Institution
city: Quezon City
country: Philippines
facility: Local Institution
city: Arkonska 4
country: Poland
facility: Local Institution
city: Bialystok
country: Poland
facility: Local Institution
city: Bydgoszcz
country: Poland
facility: Local Institution
city: Bydgoszcz
country: Poland
facility: Local Institution
city: Bydgoszcz
country: Poland
facility: Local Institution
city: Gdansk
country: Poland
facility: Local Institution
city: Gdynia
country: Poland
facility: Local Institution
city: Gdynia
country: Poland
facility: Local Institution
city: Lodz
country: Poland
facility: Local Institution
city: Lublin
country: Poland
facility: Local Institution
city: Lublin
country: Poland
facility: Local Institution
city: Poznan
country: Poland
facility: Local Institution
city: Przeworsk
country: Poland
facility: Local Institution
city: Szczecin
country: Poland
facility: Local Institution
city: Tarnobrzeg
country: Poland
facility: Local Institution
city: Warsawa
country: Poland
facility: Local Institution
city: Warsaw
country: Poland
facility: Local Institution
city: Warsaw
country: Poland
facility: Local Institution
city: Warszawa
country: Poland
facility: Local Institution
city: Warszawa
country: Poland
facility: Local Institution
city: Wroclaw
country: Poland
facility: Local Institution
city: Wroclaw
country: Poland
facility: Local Institution
city: Guarda
country: Portugal
facility: Local Institution
city: Lisboa
country: Portugal
facility: Local Institution
city: San Juan
country: Puerto Rico
facility: Local Institution
city: San Juan
country: Puerto Rico
facility: Local Institution
city: Baia Mare
country: Romania
facility: Local Institution
city: Bucharest
country: Romania
facility: Local Institution
city: Bucharest
country: Romania
facility: Local Institution
city: Bucharest
country: Romania
facility: Local Institution
city: Targu Mures
country: Romania
facility: Local Institution
city: Arkhangelsk
country: Russian Federation
facility: Local Institution
city: Kemerovo
country: Russian Federation
facility: Local Institution
city: Moscow
country: Russian Federation
facility: Local Institution
city: Moscow
country: Russian Federation
facility: Local Institution
city: Moscow
country: Russian Federation
facility: Local Institution
city: Moscow
country: Russian Federation
facility: Local Institution
city: Novosibirsk
country: Russian Federation
facility: Local Institution
city: Novosibirsk
country: Russian Federation
facility: Local Institution
city: Rostov-On Don
country: Russian Federation
facility: Local Institution
city: Ryazan
country: Russian Federation
facility: Local Institution
city: Saint Petersburg
country: Russian Federation
facility: Local Institution
city: Saint-Petersburg
country: Russian Federation
facility: Local Institution
city: Saint-Petersburg
country: Russian Federation
facility: Local Institution
city: Samara
country: Russian Federation
facility: Local Institution
city: Saratov
country: Russian Federation
facility: Local Institution
city: Saratov
country: Russian Federation
facility: Local Institution
city: St Petersburg
country: Russian Federation
facility: Local Institution
city: Tomsk
country: Russian Federation
facility: Local Institution
city: Yaroslavl
country: Russian Federation
facility: Local Institution
city: Singapore
country: Singapore
facility: Local Institution
city: Singapore
country: Singapore
facility: Local Institution
city: Bloemfontein
country: South Africa
facility: Local Institution
state: Free State
city: Centurion
country: South Africa
facility: Local Institution
state: Gauteng
city: Parktown
country: South Africa
facility: Local Institution
state: Gauteng
city: Pretoria
country: South Africa
facility: Local Institution
state: Gauteng
city: Pretoria
country: South Africa
facility: Local Institution
state: Gauteng
city: Durban
country: South Africa
facility: Local Institution
state: Kwa Zulu Natal
city: Pietermaritzburg
country: South Africa
facility: Local Institution
state: Kwa Zulu Natal
city: Bellville
country: South Africa
facility: Local Institution
state: Western Cape
city: George
country: South Africa
facility: Local Institution
state: Western Cape
city: Somerset West
country: South Africa
facility: Local Institution
state: Western Cape
city: Worcester
country: South Africa
facility: Local Institution
state: Western Cape
city: Torrevieja
country: Spain
facility: Local Institution
state: Alicante
city: Badalona
country: Spain
facility: Local Institution
state: Barcelona
city: Majadahonda
country: Spain
facility: Local Institution
state: Madrid
city: San Sebastian De Los Reyes
country: Spain
facility: Local Institution
state: Madrid
city: Cadiz
country: Spain
facility: Local Institution
city: Getafe
country: Spain
facility: Local Institution
city: Girona
country: Spain
facility: Local Institution
city: L'Hospitalet De Llobregat
country: Spain
facility: Local Institution
city: Leon
country: Spain
facility: Local Institution
city: Madrid
country: Spain
facility: Local Institution
city: Madrid
country: Spain
facility: Local Institution
city: Madrid
country: Spain
facility: Local Institution
city: Madrid
country: Spain
facility: Local Institution
city: Mourente
country: Spain
facility: Local Institution
city: Pamplona
country: Spain
facility: Local Institution
city: Salamanca
country: Spain
facility: Local Institution
city: Sant Boi De Llobregat
country: Spain
facility: Local Institution
city: Tarragona
country: Spain
facility: Local Institution
city: Toledo
country: Spain
facility: Local Institution
city: Valencia
country: Spain
facility: Local Institution
city: Chernihiv
country: Ukraine
facility: Local Institution
city: Dnipropetrovsk
country: Ukraine
facility: Local Institution
city: Donetsk
country: Ukraine
facility: Local Institution
city: Ivano-Frankivsk
country: Ukraine
facility: Local Institution
city: Ivano-Frankivsk
country: Ukraine
facility: Local Institution
city: Kharkiv
country: Ukraine
facility: Local Institution
city: Kyiv
country: Ukraine
facility: Local Institution
city: Lviv
country: Ukraine
facility: Local Institution
city: Odesa
country: Ukraine
facility: Local Institution
city: Ternopil
country: Ukraine
facility: Local Institution
city: Vinnytsia
country: Ukraine
facility: Local Institution
city: Zaporizhzhia
country: Ukraine
facility: Local Institution
city: Aberdeen
country: United Kingdom
facility: Local Institution
state: Aberdeenshire
city: Romford
country: United Kingdom
facility: Local Institution
state: Essex
city: London
country: United Kingdom
facility: Local Institution
state: Greater London
city: London
country: United Kingdom
facility: Local Institution
state: Greater London
city: Manchester
country: United Kingdom
facility: Local Institution
state: Greater Manchester
city: Hull
country: United Kingdom
facility: Local Institution
state: Humberside
city: Nottingham
country: United Kingdom
facility: Local Institution
state: Nottinghamshire
city: Bury St. Edmunds
country: United Kingdom
facility: Local Institution
state: Suffolk
city: Coventry
country: United Kingdom
facility: Local Institution
state: West Midlands
city: Dudley
country: United Kingdom
facility: Local Institution
state: West Midlands
Study officials:
affiliation: Bristol-Myers Squibb
name: Bristol-Myers Squibb
role: STUDY_DIRECTOR
References:
citation: Jamieson MJ, Byon W, Dettloff RW, Crawford M, Gargalovic PS, Merali SJ, Onorato J, Quintero AJ, Russ C. Apixaban Use in Obese Patients: A Review of the Pharmacokinetic, Interventional, and Observational Study Data. Am J Cardiovasc Drugs. 2022 Nov;22(6):615-631. doi: 10.1007/s40256-022-00524-x. Epub 2022 May 16.
citation: Liu X, Thompson J, Phatak H, Mardekian J, Porcari A, Johnson M, Cohen AT. Extended anticoagulation with apixaban reduces hospitalisations in patients with venous thromboembolism. An analysis of the AMPLIFY-EXT trial. Thromb Haemost. 2016 Jan;115(1):161-8. doi: 10.1160/TH15-07-0606. Epub 2015 Oct 8.
citation: Agnelli G, Buller HR, Cohen A, Curto M, Gallus AS, Johnson M, Porcari A, Raskob GE, Weitz JI; AMPLIFY-EXT Investigators. Apixaban for extended treatment of venous thromboembolism. N Engl J Med. 2013 Feb 21;368(8):699-708. doi: 10.1056/NEJMoa1207541. Epub 2012 Dec 8.