Clinical trial NCT00380198: A Comparison Study of Apadenoson and Adenosine to Treadmill Exercise Stress.
Official title: A Randomized, Double-Blind Comparison of Apadenoson and Adenosine to Treadmill Exercise Stress for Single-Photon Emission Computed Tomography (SPECT) Myocardial Perfusion Imaging (MPI)
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE3
Conditions: Coronary Artery Disease
Lead sponsor: Forest Laboratories
Sponsor class: INDUSTRY
First posted: 2006-09-25
Enrollment: 1500
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: DIAGNOSTIC

Brief summary: The purpose of this clinical research study is to compare Apadenoson and adenosine to treadmill exercise stress SPECT MPI


Eligibility criteria: Inclusion Criteria:

* Clinically appropriate for exercise stress testing

Exclusion Criteria:

* Contraindication to adenosine stress or inability to perform treadmill exercise test

Primary outcomes:
measure: Agreement between MPI Summed Stress Scores for extent and severity of disease
Secondary outcomes:
measure: Comparison of imaging data to 6 month event data or angiography
Other outcomes:
Locations:
city: Huntsville
country: United States
facility: Local Institution
state: Alabama
city: Santa Rosa
country: United States
facility: Local Institution
state: California
city: Bridgeport
country: United States
facility: Local Institution
state: Connecticut
city: Guilford
country: United States
facility: Local Institution
state: Connecticut
city: Newark
country: United States
facility: Local Institution
state: Delaware
city: Fort Lauderdale
country: United States
facility: Local Institution
state: Florida
city: Gainsville
country: United States
facility: Local Institution
state: Florida
city: Jacksonville Beach
country: United States
facility: Local Institution
state: Florida
city: Jacksonville
country: United States
facility: Local Institution
state: Florida
city: Jacksonville
country: United States
facility: Local Institution
state: Florida
city: Jupiter
country: United States
facility: Local Institution
state: Florida
city: Miami
country: United States
facility: Local Institution
state: Florida
city: Stuart
country: United States
facility: Local Institution
state: Florida
city: Tamarac
country: United States
facility: Local Institution
state: Florida
city: Honolulu
country: United States
facility: Local Institution
state: Hawaii
city: Aurora
country: United States
facility: Local Institution
state: Illinois
city: Bannockburn
country: United States
facility: Local Institution
state: Illinois
city: LaGrange
country: United States
facility: Local Institution
state: Illinois
city: Lombard
country: United States
facility: Local Institution
state: Illinois
city: Winfield
country: United States
facility: Local Institution
state: Illinois
city: Indianapolis
country: United States
facility: Local Institution
state: Indiana
city: Overland Park
country: United States
facility: Local Institution
state: Kansas
city: Louisville
country: United States
facility: Local Institution
state: Kentucky
city: Baton Rouge
country: United States
facility: Local Institution
state: Louisiana
city: Auburn
country: United States
facility: Local Institution
state: Maine
city: Westminster
country: United States
facility: Local Institution
state: Maryland
city: St. Louis Park
country: United States
facility: Local Institution
state: Minnesota
city: Tupelo
country: United States
facility: Local Institution
state: Mississippi
city: Kansas City
country: United States
facility: Local Institution
state: Missouri
city: Albany
country: United States
facility: Local Institution
state: New York
city: West Islip
country: United States
facility: Local Institution
state: New York
city: Cincinnati
country: United States
facility: Local Institution
state: Ohio
city: Lorain
country: United States
facility: Local Institution
state: Ohio
city: Sandusky
country: United States
facility: Local Institution
state: Ohio
city: Westlake
country: United States
facility: Local Institution
state: Ohio
city: Wyomissing
country: United States
facility: Local Institution
state: Pennsylvania
city: Simpsonville
country: United States
facility: Local Institution
state: South Carolina
city: Chattanooga
country: United States
facility: Local Institution
state: Tennessee
city: Johnson City
country: United States
facility: Local Institution
state: Tennessee
city: Houston
country: United States
facility: Local Institution
state: Texas
city: Richmond
country: United States
facility: Local Institution
state: Virginia
city: Madison
country: United States
facility: Local Institution
state: Wisconsin
Study officials:
affiliation: Bristol-Myers Squibb
name: Robert Mittleman, MD
role: STUDY_DIRECTOR
References: