Clinical trial NCT06248151: Acute Cardiovascular Responses to a Single Exercise Session in Patients With Post-COVID-19 Syndrome
Official title: Acute Cardiovascular Responses to a Single Exercise Session in Patients With Post-Covid-19 Syndrome
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Post-Acute COVID-19 Syndrome
Keywords: Post-Covid 19 Syndrome
Covid-19
fatigue
cardiovascular system
respiratory system
rehabilitation
Lead sponsor: University of Nove de Julho
Sponsor class: OTHER
First posted: 2024-02-08
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The objective of the study is to compare the acute cardiorespiratory and perceptual responses to a physical exercise session in those infected by Covid-19 with and without persistent symptoms.

Detailed description: The study will be a crossover carried out in two groups (with and without persistent symptoms of Covid-19). Participants in both groups will undergo a control session and an exercise session and cardiorespiratory and perceptual responses will be obtained before, during and after the sessions. In the exercise session, participants will perform aerobic exercises, strength exercises and muscle stretching, while in the control session participants will remain seated. Blood pressure, heart rate, cardiac autonomic modulation, peripheral oxygen saturation, vascular function and perception of affect will be obtained.

Eligibility criteria: Inclusion Criteria:

Post-Covid Syndrome group:

* have had a positive RT-PCR test for Covid-19;
* present persistent symptoms of Post Covid 19 syndrome, which have no other health explanation according to the criteria of the World Health Organization (WHO);
* have the cognitive and physical capacity to perform the exercises; It is
* low cardiovascular risk classification according to the American College of Sports Medicine criteria.

Healthy group:

* not present persistent symptoms of Post Covid 19 syndrome, which have no other health explanation according to the criteria of the World Health Organization (WHO);
* have the cognitive and physical capacity to perform the exercises; It is
* low cardiovascular risk classification according to the American College of Sports Medicine criteria.

Primary outcomes:
measure: Change in Blood pressure
timeFrame: Before and 30 and 50 minutes after the end of the exercise and control interventions
measure: Change in Heart rate variability
timeFrame: Before and 30 and 50 minutes after the end of the exercise and control interventions
measure: Change in flow mediated dilation
timeFrame: Before and 30 minutes after the end of the exercise and control interventions
measure: Change in peak exhalation flow
timeFrame: Before and 5 minutes after the end of the exercise and control interventions
measure: Change in oxygen saturation
timeFrame: Before, during and 5 minutes after the end of the exercise and control interventions
Secondary outcomes:
measure: Change in heart rate
timeFrame: Before and continuously during exercise and control interventions
measure: Change in affective response
timeFrame: Before and every 5 minutes during exercise and control interventions
Other outcomes:
Locations:
city: São Paulo
country: Brazil
facility: Universidade Nove de Julho
Study officials:
affiliation: University of Nove de Julho
name: Raphael Dias, PhD
role: STUDY_CHAIR
References: