Clinical trial NCT06705556: Effect of Active Cycle of Breathing Technique as Add on to Routine Chest Physical Therapy on Respiratory Parameters in Coronary Artery Bypass Graft Patients
Official title: Effects of Pre and Post Operative Active Cycle of Breathing Technique as Add on to Routine Chest Physical Therapy on Respiratory Parameters in Coronary Artery Bypass Graft Patients
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Coronary Artery Bypass Graft
Lead sponsor: University of Faisalabad
Sponsor class: OTHER
First posted: 2024-11-26
Enrollment: 72
Sex: ALL
Minimum age (years): 30
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: SUPPORTIVE_CARE

Brief summary: A controlled trial was conducted to determine the effect of the active cycle of breathing technique (ACBT) in improving respiratory parameters after coronary artery bypass graft surgery. The main aim of this study was to determine the effects of pre and postoperative active cycle of breathing technique (ACBT) in coronary artery disease patients undergoing coronary artery bypass graft surgery in improving respiratory parameters such as arterial blood gas (ABG), oxygen saturation (SpO2) and respiratory rate. The intervention group performed an active cycle of breathing technique with routine chest physical therapy while the control group performed routine chest physical therapy. Arterial blood gas (ABG), oxygen saturation (SpO2), and respiratory rate were measured at baseline and five days after surgery, every 2 hours on postoperative days 1, 2, and 3 and 4 hours on days 4 and 5.

Participants in the intervention group performed preoperative routine chest physical therapy sessions were followed as:

* Incentive spirometry, 3 sessions per day, 10 repetitions
* Percussions, 3 sessions per day, 20 repetitions
* 3-minutes walking, 2 sessions per day
* ACBT, 3 sessions per day

The preoperative chest physiotherapy treatment plan was continued after CABG surgery. In addition to these, the following were included postoperatively:

* Nebulization, 3 sessions per day
* 3 minutes of walking, 2 sessions per day
* ACBT, 3 sessions per day While participants in the control group performed the same pre and postoperative sessions except ACBT.

Detailed description: This single-blinded randomized controlled trial was conducted at the Faisalabad Institute of Cardiology, Faisalabad, Pakistan, to assess the effects the Active Cycle of Breathing Technique (ACBT) as add on to routine chest physical therapy in the preoperative care of coronary artery bypass graft (CABG) patients. The primary aim was to evaluate ACBT's impact on minimizing postoperative respiratory complications. A secondary aim was to educate patients in the preoperative period to reduce surgery-related stress and support respiratory drive.

Patients with coronary artery disease are generally advised bed rest to manage shortness of breath. However, CABG is an invasive procedure that involves the placement of an endotracheal tube, raising infection risks and leading to weakened respiratory muscles due to ventilation effects. Post-surgery, patients often experience reduced lung volumes and altered arterial blood gases. Adding ACBT to chest physical therapy in the preoperative period is intended to improve ventilation and arterial blood gas levels postoperatively.

The study involved 72 male and female patients, aged 30 to 65, with double or triple-vessel coronary disease and a 10 to 15-year disease history, scheduled for CABG. Screening was performed using a custom questionnaire based on inclusion and exclusion criteria, and non-probability purposive sampling was used to select participants. Patients were randomly assigned to either the intervention or control group using the lottery method. The intervention group received ACBT alongside routine chest physical therapy, while the control group received only standard chest physical therapy, both pre- and postoperatively. Patient confidentiality was maintained through informed consent.

Key study parameters included arterial blood gas (ABG) levels, oxygen saturation (SpO2), and respiratory rate, with ABG samples taken from the brachial and radial arteries and analyzed via an ABG analyzer. SpO2 was measured using a pulse oximeter, and respiratory rate was recorded on a cardiac monitor.

Eligibility criteria: Inclusion Criteria:

* Elective coronary artery bypass graft patients
* The study included both male and female
* 30 to 65 years old patients were included in this study
* Adults with stable coronary artery disease for the last 15 years

Exclusion Criteria:

* Patient with unstable vitals
* Preoperative pulmonary dysfunction
* COPD or Emphysema
* Asthma and Severe atelectasis
* Renal disorders
* Connected to the ventilator for more than 48 hours

Primary outcomes:
measure: Arterial blood gas
timeFrame: ABG test was conducted once preoperative for both groups and after surgery every 2 hours on postoperative days 1, 2, and 3, and every 4 hours on days 4 and 5.
Secondary outcomes:
measure: oxygen saturation (SpO₂)
timeFrame: SpO₂ was measured once preoperative for both groups and after surgery every 2 hours on postoperative days 1, 2, and 3, and every 4 hours on days 4 and 5.
measure: Respiratory rate
timeFrame: Respiratory rate was measured once preoperative for both groups and after surgery every 2 hours on postoperative days 1, 2, and 3, and every 4 hours on days 4 and 5.
Other outcomes:
Locations:
city: Faisalabad
country: Pakistan
facility: The University of Faisalabad
state: Punjab
city: Lahore
country: Pakistan
facility: Dr Sana Ashraf
state: Punjab
Study officials:
References: