louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01485705: Retrospective Examination of Initial Care of Severe Bacterial Infections of the Child
Official title: Frequency, Consequences and Determinants of Sub-optimal Care in the Initial Care of Severe Bacterial Infections of the Child
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Bacterial Infection
Keywords: severe bacterial infection
Lead sponsor: Nantes University Hospital
Sponsor class: OTHER
First posted: 2011-12-05
Enrollment: 371
Sex: ALL
Minimum age (years): 1
Maximum age (years): 16
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The aim of the study is to determine the frequency of sub-optimal care in the initial care (before arrival at the intensive care unit) of children from "West France regions" suffering of severe bacterial infections.The characteristic "optimal or not" of the initial medical care will be determined by 2 independent experts, blinded from each other and blinded from the issue of the care. In case of a discordance between the two experts, a third expert will be demanded. Three possibilities of conclusion will be proposed to the experts: "sure sub-optimal medical care", "possible suboptimal care" and "optimal care".


Eligibility criteria: Inclusion Criteria:

* Child from West France regions
* Aged between 1 month and 16 years old,
* Admitted at the intensive care unit for a severe bacterial infection and with the first symptoms appeared when child was at home or hospitalized since less than 48h
* Children dead at home will also be included in this study via the mobil medical urgency help unit (french term : "SAMU")

Exclusion Criteria:

* Patient not fulfilling inclusion criteria
* Child with a nosocomial infection
* Child dead or admitted at the intensive care unit following a pertussis- Child not admitted at the intensive care or not dead at home in a context of infection.
* Child with viral or fungic infection admitted at the intensive care unit.

Primary outcomes:
measure: Frequency of optimal care and of non optimal care in the initial care (before arrival at the intensive care unit) of children (from West France regions) suffering of severe bacterial infections.
timeFrame: 1day
Secondary outcomes:
measure: characteristics of sub-optimal cares
timeFrame: 1 day
measure: determinants of sub-optimal cares
timeFrame: 1 day
measure: consequences of initial sub-optimal cares
timeFrame: 1 day
Other outcomes:
Locations:
city: Nantes
country: France
facility: CHU of Nantes
Study officials:
References:
Clinical trial NCT06731205: Long-term Renal Prognosis of Neonatal Acute Kidney Injury
Official title: Long-term Renal Prognosis of Neonatal Acute Kidney Injury: A Multicenter, Prospective Cohort Study
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Neonatal Acute Kidney Injury
Keywords: Neonatal Acute Kidney Injury
Long-Term Prognosis
Prognosis and Predictive Factors
Biomarkers
Lead sponsor: Guangzhou Women and Children's Medical Center
Sponsor class: OTHER
First posted: 2024-12-12
Enrollment: 1852
Sex: ALL
Maximum age (years): 28
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who gave birth, were admitted to NICU and were diagnosed with neonatal AKI from Jan 2025 to Dec 2025 at the Women and Children's Medical Center of Guangzhou Medical University and other hospitals participating in this project.

Brief summary: The goal of this observational study is to conduct a multicenter, prospective neonatal acute kidney injury (AKI) follow-up cohort to describe the clinical characteristics of chronic kidney disease (CKD) in AKI cases within 1 year of follow-up and screen for effective biomarkers that can early warn of CKD progression. Ultimately, a neonatal AKI adverse prognosis warning model based on multidimensional data will be established to provide new data and new models for CKD management.


Eligibility criteria: Inclusion Criteria:

* Delivered in this hospital and subsequently admitted to the NICU during the study period;
* Diagnosed with neonatal AKI according to the 2015 KDIGO neonatal AKI criteria;
* Age \<28 days.

Exclusion Criteria:

* Severe hydronephrosis diagnosed by prenatal renal ultrasound;
* Patients with congenital urinary malformations, including solitary kidney, cystic dysplasia, multicystic dysplastic kidney, renal dysplasia, and obstructive uropathy;
* Newborns who required congenital heart surgery within the first 7 days after birth;
* Newborns whose mothers had a history of renal failure;
* Death within 48 hours after birth;
* Other genetic syndromes or medical conditions were not eligible for inclusion according to the attending neonatologist's judgment.

Primary outcomes:
measure: Incidence of chronic kidney disease (CKD)
timeFrame: 1-3 years
Secondary outcomes:
measure: Mortality
timeFrame: 1-3 years
measure: Incidence of renal replacement therapy
timeFrame: 1-3 years
measure: Incidence of proteinuria
timeFrame: 1-3 years
measure: Incidence of height retardation
timeFrame: 1-3 years
measure: Incidence of hypertension
timeFrame: 1-3 years
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT02309905: Evaluation of Tele-expertise for Inmates With a Dermatological Lesion
Official title: Evaluation of Tele-expertise for Inmates With a Dermatological Lesion
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Skin Disease
Keywords: inmates
skin lesion
telemedicine
Lead sponsor: Assistance Publique - Hôpitaux de Paris
Sponsor class: OTHER
Collaborators: name: Agence Regionale de Sante d'Ile de France
First posted: 2014-12-05
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Inmates

Brief summary: The purpose of this study is to determine whether Tele-expertise would be effective and cost-effective by reducing the number of secure transportations for inmates in need of a dermatological consultation


Eligibility criteria: Inclusion Criteria:

* Dermatological expertise required

Exclusion Criteria:

* None

Primary outcomes:
measure: Proportion of a dermatological expertise among those required
timeFrame: 1 month after the end of the study
Secondary outcomes:
measure: Number of hospitalizations for a dermatological reason
timeFrame: 1 month after the end of the study
measure: Overall costs
timeFrame: 6 months after the end of the study
measure: Time to a dermatological expertise
timeFrame: 1 month after the end of the study
measure: Number of usual consultations needed after Tele-expertise
timeFrame: 1 month after the end of the study
Other outcomes:
Locations:
city: Cergy-Pontoise
country: France
facility: UCSA Osny
city: Meaux
country: France
facility: UCSA Meaux
city: Nanterre
country: France
facility: UCSA Nanterre
city: Réau
country: France
facility: UCSA Réau
city: Villepinte
country: France
facility: UCSA Villepinte
Study officials:
affiliation: Versailles Hospital
name: François Moreau, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: DRCD URC Eco. Assistance Publique - Hôpitaux de Paris
name: Isabelle Durand-Zaleski, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Kidholm K, Ekeland AG, Jensen LK, Rasmussen J, Pedersen CD, Bowes A, Flottorp SA, Bech M. A model for assessment of telemedicine applications: mast. Int J Technol Assess Health Care. 2012 Jan;28(1):44-51. doi: 10.1017/S0266462311000638.
citation: Zarca K, Charrier N, Mahe E, Guibal F, Carton B, Moreau F, Durand-Zaleski I. Tele-expertise for diagnosis of skin lesions is cost-effective in a prison setting: A retrospective cohort study of 450 patients. PLoS One. 2018 Sep 24;13(9):e0204545. doi: 10.1371/journal.pone.0204545. eCollection 2018.
citation: Charrier N, Zarca K, Durand-Zaleski I, Calinaud C; ARS Ile de France telemedicine group. Efficacy and cost effectiveness of telemedicine for improving access to care in the Paris region: study protocols for eight trials. BMC Health Serv Res. 2016 Feb 8;16:45. doi: 10.1186/s12913-016-1281-1.
Clinical trial NCT02871505: The Association Between Molecular Typing of Treponema Pallidum and Treatment Efficacy and Clinical Findings
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Syphilis
Lead sponsor: Peking Union Medical College Hospital
Sponsor class: OTHER
First posted: 2016-08-18
Enrollment: 150
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The investigators compare the treatment results and clicical presentations of different Molecular subtyping of Treponema pallidum


Eligibility criteria: Inclusion Criteria

1. Persons with confirmed early symptomatic syphilis (primary or secondary) or high-titer latent syphilis

Exclusion Criteria:

1. Pregnant woman
2. Known allergy to penicillin
3. RPR titers were found to be 1:8 or less

Primary outcomes:
measure: rapid plasma regain titer
timeFrame: 6 months after treatment
Secondary outcomes:
Other outcomes:
Locations:
city: Beijing
country: China
facility: Department of Dermatology and Venereology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
Study officials:
References:
Clinical trial NCT01373905: Stepwise Positive End Expiratory Pressure Elevation For Lung Recruitment in Acute Respiratory Distress Syndrome (ARDS)
Official title: Stepwise PEEP Elevation With Determination of the Alveolar Collapsing Pressure Versus Sustained Lung Inflation as a Recruitment Maneuver in Patients With ARDS
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Acute Respiratory Distress Syndrome
Keywords: ARDS
PEEP
Recruitment maneuver
Lead sponsor: University of Alexandria
Sponsor class: OTHER
First posted: 2011-06-15
Enrollment: 24
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Acute respiratory distress syndrome is a severe lung disease caused by a variety of direct and indirect issues. It is characterized by inflammation of the lung parenchyma leading to impaired gas exchange and persistent hypoxemia. This condition is often fatal, usually requiring mechanical ventilation. Recruitment maneuver aimed to enhance the effect of mechanical ventilation.The objective of this study was to compare safety and efficacy of two lung recruitment maneuvers.

Detailed description: In patients with acute respiratory distress syndrome (ARDS), protective lung strategy and positive end expiratory pressure (PEEP) therapy should be started as early as possible to avoid lung damage by high pressures, volumes and fraction of inspired oxygen (FiO2). Recruitment is a strategy aiming at re-expanding the collapsed lung tissue and then maintaining an adequate level of PEEP to prevent subsequent de-recruitment. The objective of this study was to compare safety and efficacy of two lung recruitment maneuvers (RM): stepwise PEEP elevation with determination of the alveolar collapsing pressure versus sustained lung inflation in ARDS patients

Eligibility criteria: Inclusion Criteria:

* ARDS
* lung injury score more than 2.5
* on mechanical ventilation

Exclusion Criteria:

* hemodynamic instability
* left heart failure
* pneumothorax
* COPD
* restrictive lung disease

Primary outcomes:
measure: All cause mortality
timeFrame: 30 days
Secondary outcomes:
measure: Efficacy
timeFrame: 24 hours
Other outcomes:
Locations:
city: Alexandria
country: Egypt
facility: Faculty of Medicine
Study officials:
affiliation: Faculty of Medicine, Alexandria University, Egypt
name: Ahmed M El-Mehalawy, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Borges JB, Okamoto VN, Matos GF, Caramez MP, Arantes PR, Barros F, Souza CE, Victorino JA, Kacmarek RM, Barbas CS, Carvalho CR, Amato MB. Reversibility of lung collapse and hypoxemia in early acute respiratory distress syndrome. Am J Respir Crit Care Med. 2006 Aug 1;174(3):268-78. doi: 10.1164/rccm.200506-976OC. Epub 2006 May 11.
Clinical trial NCT01484405: Anterolateral Versus Posterior Approach for Total Hip Arthroplasty After Displaced Femoral Neck Fracture
Official title: Anterolateral Versus Posterior Approach for Total Hip Arthroplasty After Displaced Femoral Neck Fracture
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Femur Fracture
Keywords: surgical approach for total hip arthroplasty
Lead sponsor: Florida Orthopaedic Institute
Sponsor class: NETWORK
Collaborators: name: Orthopaedic Trauma Association
First posted: 2011-12-02
Enrollment: 16
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: There are two surgical approaches (incision types) used by surgeons who do total hip replacements. The purpose of this study is to determine which type of surgical approach (incision type) produces the best results for patients who have a total hip replacement.

Null Hypothesis : There is no difference in complication rate, functional outcome, surgical time, or blood loss when comparing outcomes in patients receiving THA to hemiarthroplasty or ORIF for femoral neck fractures.

Detailed description: Patients undergoing Total hip Arthroplasty following displaced femoral neck fracture, will be consented and randomized to one of two surgical approaches ( anterior or posterior).

Eligibility criteria: Inclusion Criteria:

* Displaced femoral neck fracture
* Age 65 years or older
* Acute, femoral neck fracture

Exclusion Criteria:

Cognitive impairment

* Active Infection
* Limited functional capacity (nursing home resident, non-ambulatory, severe cardiorespiratory disease)
* Limited life expectancy
* Pathologic fracture (tumor)
* Acetabular fractures

Primary outcomes:
measure: dislocation rates
timeFrame: 12 months
Secondary outcomes:
measure: other complications
timeFrame: 12 months
Other outcomes:
Locations:
city: Tampa
country: United States
facility: Tampa general Hospital
state: Florida
city: Tampa
country: United States
facility: St Josephs Hospital
state: Florida
Study officials:
affiliation: Florida Orthopaedic Institute
name: David Watson, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01501305: Influence of Carob and Probiotics on Acute Diarrhea in Children
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
PHASE2
Conditions: Diarrhea
Keywords: influence
carob powder
probiotics
duration
Lead sponsor: Hillel Yaffe Medical Center
Sponsor class: OTHER_GOV
First posted: 2011-12-29
Enrollment: 100
Sex: ALL
Minimum age (years): 3
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Comparison of Carob powder with probiotics vs oral hydration solution in diarrhea treatment in children.


Eligibility criteria: Inclusion Criteria:

* Acute diarrhea

Exclusion Criteria:

* Dehydration
* Chronic diseases
* Chronic diarrhea (more than 2 weeks)
* Septic shock
* Hypovolemia
* On medication
* Pregnancy

Primary outcomes:
measure: Reduction in diarrhea
timeFrame: One week
Secondary outcomes:
measure: Number of days until no diarrhea bowel movements
timeFrame: 1 week
Other outcomes:
Locations:
city: Hadera
country: Israel
facility: Hillel Yaffe Medical Center
Study officials:
References:
Clinical trial NCT00600405: The Efficacy of Tamsulosin in the Treatment of Ureteral Stones in Emergency Department Patients
Official title: The Efficacy of Tamsulosin in the Treatment of Ureteral Stones in Emergency Department Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Nephrolithiasis
Ureteral Calculi
Keywords: Nephrolithiasis
Ureteral Calculi
Lead sponsor: MaineHealth
Sponsor class: OTHER
Collaborators: name: Maine Medical Center Mentored Research Committee
First posted: 2008-01-25
Enrollment: 81
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine the efficacy of the α-adrenergic antagonist tamsulosin in the treatment of adult emergency department (ED) patients with ureteral colic secondary to lower ureteral calculus. We hypothesize that there will be no difference in outcomes for subjects treated with and without tamsulosin.

Detailed description: This prospective, randomized controlled trial seeks to compare outcomes for adult emergency department patients with lower ureteral calculus. Subjects will be randomized to receive treatment with ibuprofen and oxycodone alone (standard therapy) or standard therapy plus tamsulosin 0.4mg orally once daily for ten days.

Eligibility criteria: Inclusion Criteria:

* 18 years of age or older;
* able to read, write, and speak English;
* able to use the NRS pain scale; and
* computed tomography diagnosed single lower ureteral calculus

Exclusion Criteria:

* allergy or sensitivity to the study drug (tamsulosin hydrochloride \[Flomax\]);
* sulfa/sulfonamide allergy;
* inability to provide informed consent;
* lithiasis of the ureteral intramural tract;
* acute or chronic renal failure;
* fever;
* presence of multiple ureteral stones;
* peptic ulcer disease;
* liver failure;
* concomitant treatment with alpha-lytic drugs, calcium antagonists, nitrates, or vardenafil (Levitra);
* pregnancy;
* breastfeeding; or
* a history of urinary surgery or endoscopic treatment.

Primary outcomes:
measure: Rate of spontaneous ureteral stone expulsion
timeFrame: 48, 120, 336 hours
Secondary outcomes:
measure: Time to spontaneous ureteral stone expulsion.
timeFrame: 48, 120, 336 hours
measure: Self-reported NRS-11 pain scores.
timeFrame: 48, 120, 336 hours
measure: Number of colicky pain episodes.
timeFrame: 48, 120, 336 hours
measure: Number of days missed work or usual functional ability.
timeFrame: 48, 120, 336 hours
measure: Number of return ED visits or unscheduled PCP visits for continued pain.
timeFrame: 48, 120, 336 hours
measure: Amount of narcotic pain medication used.
timeFrame: 48, 120, 336 hours
measure: Adverse medication-related events.
timeFrame: 48, 120, 336 hours
Other outcomes:
Locations:
city: Portland
country: United States
facility: Maine Medical Center
state: Maine
Study officials:
affiliation: MaineHealth
name: Andrew D Perron, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01353105: Evaluation and Reconditioning of Marginal Lung Donors to Transplantation by ex Vivo Lung Perfusion
Official title: Evaluation and Reconditioning of Marginal Lung Donors to Transplantation by ex Vivo Lung Perfusion
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Respiratory Tract Diseases
Keywords: cystic fibrosis
chronic obstructive pulmonary disease
pulmonary fibrosis
Lead sponsor: InCor Heart Institute
Sponsor class: OTHER
Collaborators: name: Fundação de Amparo à Pesquisa do Estado de São Paulo
First posted: 2011-05-12
Enrollment: 20
Sex: ALL
Minimum age (years): 12
Maximum age (years): 70
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Only about 15% of the potential candidates for lung donation are considered suitable for transplantation. A new method for ex vivo lung perfusion (EVLP) has been developed and can be used for evaluation and reconditioning of "marginal" and unacceptable lungs. The ´purpose of this study is to analyse the executability and safety of ex vivo lung perfusion pulmonary ex vivo in marginal donors.

Detailed description: Donor Inclusion criteria:

* Age \< 55 years-old;
* Smoking history \< 20 pack-year;
* Clear chest radiograph;
* Absence of significant chest trauma;
* Absence of purulent secretions and gastric contents at bronchoscopy;
* PaO2 \< 300 mm Hg (FIO2 1.0, PEEP 5 cmH2O)

Exclusion criteria:

* Lungs presenting PO2 \< 400 mmHg after ex vivo lung perfusion

Eligibility criteria: Inclusion Criteria:

* Age \< 55 years-old;
* Smoking history \< 20 pack-year;
* Clear chest radiograph;
* Absence of significant chest trauma;
* Absence of purulent secretions and gastric contents at bronchoscopy;
* PaO2 \< 300 mm Hg (FIO2 1.0, PEEP 5 cmH2O)

Exclusion Criteria:

* Lungs presenting PO2 \< 400 mmHg after ex vivo lung perfusion

Primary outcomes:
measure: 30-days mortality
timeFrame: 30 days after ex vivo lung transplantation
measure: Respiratory complications (primary graft dysfunction, infection, rejection, bronchiolitis obliterates syndrome)
timeFrame: 30 days after the ex vivo lung transplantation
measure: 12-months survival
timeFrame: 12 months survival after ex vivo lung transplantation
Secondary outcomes:
measure: Oxygenation index (PaO2/FiO2)on ICU arrival and 72 hours
timeFrame: 72 hours after ex vivo lung transplantation
measure: Mechanical ventilation time
timeFrame: 30 days after ex vivo lung transplantation
measure: Hospital and ICU time of stay
timeFrame: 12 months after ex vivo lung transplantation
measure: Non-respiratory complications (arrhythmia, renal failure, sepsis)
timeFrame: 30 days after ex vivo lung transplantation
Other outcomes:
Locations:
city: São Paulo
country: Brazil
facility: INCOR - Heart Institute
state: SP
Study officials:
affiliation: InCor Heart Institute
name: Fabio B Jatene, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03708705: Liquid Biopsy-based Monitoring System for Relapse of HCC After Liver Transplantation: A Multi-center and Prospective Study
Official title: Liquid Biopsy-based Monitoring System for Relapse of Hepatocellular Carcinoma Associated With Hepatitis B After Liver Transplantation: A Multi-center and Prospective Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Hepatocellular Carcinoma
Lead sponsor: Zhejiang University
Sponsor class: OTHER
First posted: 2018-10-17
Enrollment: 500
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: hospitalization patients

Brief summary: This study aims to develop a novel, reliable, liquid biopsy-based biomarker system for relapse of HCC associated with hepatitis B after liver transplantation.

Detailed description: Relapse of hepatocellular carcinoma (HCC) is one of the leading causes of death after liver transplantation (LT). Detection of cancer at an earlier stage of the disease can be critical to improve patient survival. Liquid biopsy is a revolutionary technique that is opening previously unexpected perspectives. It consists of circulating extracellular vesicles, nucleic acids (DNA and RNA) and circulating tumor cells. The detection and isolation of circulating tumor cells, circulating tumor DNA and exosomes, as a source of genomic and proteomic information in patients with cancer. Regarding these promising and potential transformative tools, as well as the issues still needed to be addressed for adopting various liquid biopsy approaches into clinical practice. This study aims to develop a novel, reliable, liquid biopsy-based biomarker system for relapse of HCC associated with hepatitis B after liver transplantation.

Eligibility criteria: Inclusion Criteria:

transplants for HCC

Exclusion Criteria:

Liver transplantation due to other disease

Primary outcomes:
measure: relapse rate of tumor
timeFrame: two years
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References: