Clinical trial NCT05330637: Study on the Influence of Climatic and Environmental Factors on Respiratory Diseases in Sanya, Hainan Province, China.
Official title: Study on the Influence of Climatic and Environmental Factors on Respiratory or Allergic Diseases in Sanya, Hainan Province, China.
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Asthma
Allergic Rhinitis
Chronic Obstructive Pulmonary Disease(COPD)
Atopic Dermatitis
Eczema
Urticaria
Bronchitis
Bronchiectasis Adult
Emphysema
Keywords: Asthma
Allergic Rhinitis
Climatotherapy
Chronic Obstructive Pulmonary Disease(COPD)
Atopic Dermatitis
Climate
Environment
Lead sponsor: Shanghai Jiao Tong University School of Medicine
Sponsor class: OTHER
First posted: 2022-04-15
Enrollment: 800
Sex: ALL
Minimum age (years): 3
Maximum age (years): 80
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: 1. 50-80 years-old migratory people with asthma, allergic rhinitis, COPD or atypical dermatitis from northeast China.
2. 3-12 years-old children with asthma, allergic rhinitis, atypical dermatitisin in Sanya.

Brief summary: To investigate the Influence of Climatic and Environmental Factors on Respiratory or Allergic Diseases in Sanya.

Detailed description: The study is an observational research, which will recruit the community migratory old people and children at school using cluster sampling in Sanya by Sanya Maternal and Child Health Care Hospital (Sanya Women and Children's Hospital). Sanya Central Hospital(Hainan Third People's Hospital) and People's Hospital of Sanya will assist to diagnose old people disease. The data of climate and environment will be obtained from Sanya Meteorological Administration and Sanya Municipal Ecology and Environment Bureau.

1. The primary purpose is to investigate the influence of the unique tropical climate and environmental factors on the migratory old people with diseases such as asthma, allergic rhinitis, COPD or atopic dermatitis in Sanya from northern China, and to provide scientific evidence for publicity of the tourism and the health care industry.
2. The secondary purpose is to investigate prevalence and risk factors of asthma, allergic rhinitis and atopic dermatitis among children in Sanya, which will provide a base for prevention and control strategies.
3. The third purpose is to retrospectively analyze the influence of climate and environmental factors in Sanya on children with asthma, allergic rhinitis and atopic dermatitis in the past decade, and a comparative analysis of the incidence on children in Sanya and Shanghai.

Eligibility criteria: Inclusion Criteria:

* 50-80 years-old migratory people with asthma, allergic rhinitis, COPD or atopic dermatitis from northern China;
* 3-12 years-old children in Sanya;
* Agree to participate this study.

Exclusion Criteria:

* Disagree to participate this study;
* Having other respiratory diseases which can influence airflow, such as lung cancer, tuberculosis, pneumonia, bronchiectasis, etc;
* Inability to understand the study procedures or inability/reluctance to answer questionnaire judged by the investigator.

Primary outcomes:
measure: The difference of migratory old people with asthma, COPD, allergic rhinitis or atopic dermatitis between winter-spring season in tropical Sanya, Hainan Island and summer-autumn season in northeast China.
timeFrame: 3 year
Secondary outcomes:
measure: Asthma control of migratory old people with asthma.
timeFrame: 1-3 year
measure: Asthma life quality of migratory old people with asthma.
timeFrame: 1-3 year
measure: Lung function of migratory old people with asthma or COPD.
timeFrame: 1-3 year
measure: The respiratory function of migratory old people with COPD.
timeFrame: 1-3 year
measure: Allergens will be detected in migratory old people with asthma, allergic rhinitis or atopic dermatitis.
timeFrame: 1-3 year
measure: Inflammatory factors will be detected in migratory old people with asthma, allergic rhinitis or atopic dermatitis.
timeFrame: 1-3 year
measure: The change of asthma incidence rate in migratory old people .
timeFrame: 1-3 year
Other outcomes:
Locations:
city: Sanya
country: China
facility: Sanya Women and Children's Hospital, Shanghai Children's Medical Center, School of Medicine, Shanghai Jiao Tong University
state: Hainan
Study officials:
affiliation: Shanghai Children's Medicial Center affiliated Shanghai Jiao Tong University School of Medicine
name: Shijian Liu, Ph.D
role: PRINCIPAL_INVESTIGATOR
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