louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01393197: Transcatheter Arterial Chemoembolization With KMG Microsphere Treating Advance-stage Hepatocellular Carinomas (TACE-KMG)
Official title: Clinical Trial of Transcatheter Arterial Chemoembolization (TACE)With KMG Microsphere Treating Advance-stage Hepatocellular Carinomas
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Carcinoma, Hepatocellular
Keywords: HCC
TACE
Lead sponsor: Tianjin Medical University Cancer Institute and Hospital
Sponsor class: OTHER
First posted: 2011-07-13
Enrollment: 2480
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the effects of Transcatheter Arterial Chemoembolization (TACE) with KMG microsphere in treating HCC. And to determine which one is better,KMG microsphere or lipiodol?

Detailed description: The most important part of effect in TACE is embolization .But there is no clinical trials on which one is better,KMG microsphere or lipiodol? what effect did chemo play in the TACE treating HCC? Which one is better,routine dose or low dose? Experts in USA and Japan had their own researches and standpoints.We think it is important to push a clinical trail to answer these problem.

Eligibility criteria: Inclusion Criteria:

* Hepatocellular Carinomas with diagnosis of pathology or cytology or consistent with China 2001 guideline of Clinical Diagnosis Hepatocellular Carinomas clinical stage（The Barcelona Liver Clinic staging system,BCLC B and C)，or can not receive surgical intervention
* liver function:Child-Pugh A、B
* PST 0-1（Eastern Cooperative Oncology Group Performance Score ,ECOG）
* Lifespan≥6 months
* First time to receive treatment
* Can accept the follow up
* informed consent was gotten
* the number of lesion ≤ 5

Exclusion Criteria:

* pregnant or lactation woman
* emotional disturbance
* serious heart ,lung disfunction or serious diabetes mellitus
* serious reactiveness infections;（exp:type B or C hepatitis）
* liver function :Child-Pugh Score C
* thrombocyte\<6×109/L
* diffuse HCC
* widespread metastasis
* serious atherosclerosis
* acquired immunodeficiency syndrome;AIDS
* thrombosis or thrombosis event in 6 months
* renal inadequacy who need hemodialysis or peritoneal dialysis
* with other tumors except basal cell carcinoma and carcinoma in situ of cervix
* serious alimentary tract hemorrhage in 4 weeks

Primary outcomes:
measure: Time to progression
timeFrame: 3 years
Secondary outcomes:
measure: total survival
timeFrame: 3 years
measure: remission rate
timeFrame: 3 years
Other outcomes:
Locations:
city: Tianjin
country: China
facility: Tianjin Medical University Cancer Institute and Hospital
state: Tianjin
Study officials:
affiliation: Tianjin Medical University Cancer Institute and Hospital
name: Zhi Guo, MD
role: STUDY_CHAIR
References:
Clinical trial NCT01137097: Lateral Neck Sentinel Lymph Node Biopsy(LSLNB)in PTC
Official title: Value of Sentinel Lymph Node Biopsy to Lateral Neck Lymph Node in Thyroid Carcinoma: Prospective Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
PHASE3
Conditions: Thyroid Neoplasm
Lead sponsor: Samsung Medical Center
Sponsor class: OTHER
First posted: 2010-06-04
Enrollment: 278
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Objective: To investigate the incidence of lateral neck node occult metastasis and to show the usefulness of sentinel lymph node biopsy (SLNB) in the detection of lateral neck node metastasis in thyroid carcinoma, the investigators used a radioisotope to detect the sentinel lymph node.

Summary Background Data: Although occult lymph node metastasis to the lateral neck compartment is common in papillary thyroid carcinoma, the incidence and patterns of lateral neck node metastasis in papillary carcinoma are not known.

Detailed description: On the day of the operation, patients underwent preoperative lymphoscintigraphy after the intratumoral injection of a Tc-99m phytate 1 mCi in 0.1-0.2 mL 0.9% NaCl under ultrasonographic guidance. Total thyroidectomy or lobectomy with central neck dissection preceded SLN detection to avoid interference by primary tumor radioactivity. After total thyroidectomy or lobectomy, the dissections were performed toward the internal jugular chain beneath the sternocleidomastoid muscle. A handheld, collimated gamma probe and lymphoscintigraphy were used to scan the lateral compartments (through skin and under the SCM) for "radioactive" lymph nodes. Removed SLNs were submitted immediately for frozen biopsy. If any of the SLNs were positive for metastasis on the frozen sections, MRND was performed immediately. In cases for which the frozen section was negative but the final pathology report detailed microscopic positivity in the lateral sentinel nodes, RAI ablations were performed without additional MRND.

Eligibility criteria: Inclusion Criteria:

* Cases with tumors larger than 1 cm in size or with suspicious central neck node metastasis in Papillary thyroid cancer

Exclusion Criteria:

* The patient with definite metastatic lymph node in lateral neck compartment

Primary outcomes:
measure: The usefulness of lateral sentinel lymph node biopsy in PTC
timeFrame: at Oct 2011
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
Study officials:
affiliation: Samsung Medical Center
name: Se Kyung Lee, M.D
role: STUDY_DIRECTOR
References:
Clinical trial NCT04025697: Complete Denture Tooth Movement in Digital Light Processing Versus Conventional Fabrication Techniques
Official title: Complete Denture Tooth Movement in Digital Light Processing Versus Conventional Fabrication Techniques: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Rapid Prototyping in Dentures
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2019-07-19
Enrollment: 14
Sex: ALL
Minimum age (years): 40
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The purposes of this study are to compare the denture tooth movement, the amount of occlusal adjustment needed and the chairside time required for CAD-CAM and conventional dentures.

PICOT Format:

P: completely edentulous patients. I: Complete denture fabricated by digital light processing method. C: Complete denture fabricated by the conventional method.

O:

Primary Outcome: Denture tooth movement

Secondary outcomes:

* Amount of occlusal adjustments needed
* Chairside time T: Three months with a wash-up period of 2 weeks


Eligibility criteria: Inclusion Criteria:

* Age ranging from 40-70 years.
* Cooperative patients with no history of psychological diseases.
* Completely edentulous patients with types I, II and III mandibles according to McGarry et al.

Exclusion Criteria:

* Pathological changes of residual ridges
* Patients with xerostomia.
* Patients with flabby ridges.
* Temporomandibular disorders and neuromuscular disorders e.g. Parkinson's disease

Primary outcomes:
measure: The amount of tooth movement
timeFrame: 8 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Cairo University
name: Iman A Radi
role: STUDY_DIRECTOR
References:
Clinical trial NCT02243397: Molecular and Cellular Analysis of Breast Cancer
Official title: Molecular and Cellular Analysis of Breast Cancer
Study type: OBSERVATIONAL
Overall status: SUSPENDED
Conditions: Breast - Female
Breast - Male
Lead sponsor: Stanford University
Sponsor class: OTHER
First posted: 2014-09-17
Enrollment: 500
Sex: FEMALE
Minimum age (years): 18
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: breast cancer patients at Stanford Cancer Center

Brief summary: The purpose of the study is to investigate the different types and subtypes of cells found in breast tumors. The investigators will do this using a variety of molecular analysis tools that may allow for improved tests. The different types of cells in breast cancer impacts the way individuals respond to various treatments.


Eligibility criteria: Inclusion Criteria:

1. Histologically proven diagnosis of breast cancer or a carcinoma of unknown primary consistent with the presentation of a primary breast malignancy.
2. 18 years of age or older.
3. Ability to understand and the willingness to sign a written informed consent do

Exclusion Criteria:

* None

Primary outcomes:
measure: levels of GM-CSF in plasma
timeFrame: 10 years
Secondary outcomes:
Other outcomes:
Locations:
city: Stanford
country: United States
facility: Stanford University Cancer Institute
state: California
Study officials:
affiliation: Stanford University
name: Kathleen Horst
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05125497: Natural Cycle, Minimal Stimulation and Conventional IVF: a Registry-based Study
Official title: Natural Cycle, Minimal Stimulation and Conventional IVF: a Registry-based Comparison of the IVF Treatments, Their Efficacy and Pregnancy Outcomes
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: IVF
Lead sponsor: Universitätsklinik fur Frauenheilkunde, Inselspital Bern
Sponsor class: OTHER
First posted: 2021-11-18
Enrollment: 3000
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients aiming to do In Vitro Fertilisation with fresh embryo transfer

Brief summary: International prospective registry-based study of different types of In Vitro Fertilisation (IVF) and their outcome.

Detailed description: One year of prospective collection of descriptive In-Vitro-Fertilisation data. The data will be collected in 13 In-Vitro-Fertilisation-centres

Eligibility criteria: Inclusion criteria: In Vitro Fertilisation and signed informed consent

Exclusion criteria:

* Medical freezing
* Social freezing
* thawed cycles

Primary outcomes:
measure: Implantation rate
timeFrame: 1 year
Secondary outcomes:
measure: Number of oocytes
timeFrame: 1 Year
measure: Clinical pregnancy rate
timeFrame: 1 year
measure: Pregnancy outcome
timeFrame: 1 year
measure: In Vitro Fertilisation complications rates
timeFrame: 1 year
Other outcomes:
Locations:
city: Bern
country: Switzerland
facility: Universitätsfrauenklinik Bern
Study officials:
References:
Clinical trial NCT03309397: Stress Urinary Incontinence of Sporting Teenager
Official title: Stress Urinary Incontinence in Teenage Girls Practicing Sports
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Urinary Incontinence, Stress
Keywords: adolescent sports
Lead sponsor: University Hospital, Brest
Sponsor class: OTHER
First posted: 2017-10-13
Enrollment: 103
Sex: FEMALE
Minimum age (years): 10
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Sporting Young Girl

Brief summary: Physical activity and sport are beneficial to the cardiovascular system, the musculoskeletal system and many chronic pathologies. The High Authority of Health (HAS) recommends a regular practice. However, depending on the discipline and level of practice, it may be responsible for traumatic injuries, degenerative musculoskeletal injuries, overtraining, eating disorders or cardiovascular events. It also promotes urinary stress incontinence, by increasing intra-abdominal pressure in some situations.

The prevalence of urinary leakage in the athlete depends of the practiced physical activity. A classification of the sports activities can be carried out according to the risk of increased pressures on the pelvic floor:

* high-risk sports: trampoline (10.17), acrobatic gymnastics, aerobics, athletics (jumping hedges, heights, triple jump), horse riding, basketball, volleyball, handball, martial arts;
* moderate-risk sports: tennis, skiing ...
* low risk sports: walking, swimming, cycling, rollerblading, golf ... In sports, urinary incontinence also depends of the practiced movements (jumps, abdominal exercises ...), and the occurence of sports activity. This disorder has even become one of the concerns of federal sports authority (INSEP).

However, there is no data regarding stress incontinence of sports teenagers found n the literature on


Eligibility criteria: Inclusion Criteria:

* Between 10 and 18 years
* Consultation in medical sporting center

Exclusion Criteria:

* urge incontinence

Primary outcomes:
measure: prevalence of stress urinary incontinence in adolescent girls engaged in extra-scholar sports
timeFrame: Day 0
Secondary outcomes:
measure: Delay of urinary incontinence according to the first menstruations
timeFrame: 12 months
Other outcomes:
Locations:
city: Brest
country: France
facility: CHRU de Brest
Study officials:
References:
Clinical trial NCT03964597: Objective Measurements of Lens Opacification After Intravitreal Injections
Official title: Objective Measurements of Lens Opacification After Intravitreal Injections (MOC-IVT)
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Lens Opacification
Intravitreal Injections (IVT)
Keywords: Cataract
objective scatter index (OSI)
average lens density (ALD)
Lead sponsor: Fondation Ophtalmologique Adolphe de Rothschild
Sponsor class: NETWORK
First posted: 2019-05-28
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with an indication for intravitreal injection (IVT) for medical condition.

Brief summary: The main hypothesis is the opacification of the lens would be increase by the IVT.

The opacification of the lens can be objectived by :

* the objective scatter index (OSI) on the OQAS device
* the average lens density (ALD) on the IOLMaster device.

Eligible patients will be followed at least 12 months after in intravitreal injection and the opacification of their lens is regularly controlled with OSI and ALD.

The objective is to study the dynamics of lens opacification in IVT-treated eyes evaluated by OSI for at least 1 year.


Eligibility criteria: Inclusion criteria:

* An indication of an intravenous injection of a dexamethasone 700 μg (Ozurdex®) or anti-VEGF for at least one of the two eyes for macular edema or neovessels linked to DMLA, retinal venous occlusion, diabetic macular edema or posterior uveitis
* Phake patient, at least of the injected eye

Exclusion criteria:

- Pseudophakia of the injected eye

Primary outcomes:
measure: Value of the OSI (Objective Scatter Index) in one year of follow-up after IVT
timeFrame: 12 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04582097: Ramipril in Pediatric Patients on Hemodialysis
Official title: Impact of Angiotensin-converting Enzyme Inhibitor on Pediatric Hemodialysis Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
PHASE3
Conditions: Hemodialysis
Keywords: angiotensin-convertting enzyme inhibitor
ramipril
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2020-10-09
Enrollment: 135
Sex: ALL
Minimum age (years): 8
Maximum age (years): 16
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of the study is to evaluate the effect of Ramipril in pediatric patients on regular hemodilaysis

Detailed description: Evaluate the effect of Ramipril on blood pressure, heart rate, Endothelial dysfunction and inflammatory markers in pediatric patients on regular hemodilaysis and the correlation of response with ACE I/D polymorphisms.

Eligibility criteria: Inclusion Criteria:

* Patients \< 16 years old
* Patients who have been on regular HD for 6 months or longer
* Hypertension at enrollment

Exclusion Criteria:

* History of active connective tissue disease
* Acute infection within 1 month prior to the study
* Advanced liver disease
* Gastrointestinal dysfunction requiring parental nutrition or active malignancy
* Use of medications such as immunosuppressive drugs within 1 month prior to the study
* Use of anti-inflammatory medications
* Use of vitamin E at a dose higher than 60 IU per day or vitamin C higher than 500 mg per day
* History of myocardial infarction or cerebrovascular event within 3 months prior to the study
* History of ACE inhibitor-associated angioedema
* Inability to discontinue ACE inhibitors or ARBs

Primary outcomes:
measure: concentration of Asymmetric dimethylarginine (ADMA)
timeFrame: 16 weeks
measure: concentration of high-sensitivity C-reactive protein (Hs-CRP )
timeFrame: 16 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Ain Shams University Hospital
Study officials:
affiliation: university
name: Ain Sh University
role: PRINCIPAL_INVESTIGATOR
References:
citation: Ateya AM, El Hakim I, Shahin SM, El Borolossy R, Kreutz R, Sabri NA. Effects of Ramipril on Biomarkers of Endothelial Dysfunction and Inflammation in Hypertensive Children on Maintenance Hemodialysis: the SEARCH Randomized Placebo-Controlled Trial. Hypertension. 2022 Aug;79(8):1856-1865. doi: 10.1161/HYPERTENSIONAHA.122.19312. Epub 2022 Jun 10.
Clinical trial NCT01897597: Clinical Drug Trial in Healthy Male Subjects to Determine and Compare the Blood Concentrations of BI 144807 Following Administration as Oral Solution and Tablet Under Fasted and Fed Conditions
Official title: An Open-label, Single Dose, Randomised, Crossover Trial in Healthy Male Subjects to Investigate the Relative Bioavailability of Tablet and Oral Solution of Two Doses of BI 144807 and Relative Bioavailability of BI 144807 When Administered as Tablet Under Fed and Fasted Conditions
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Healthy
Lead sponsor: Boehringer Ingelheim
Sponsor class: INDUSTRY
First posted: 2013-07-12
Enrollment: 31
Sex: MALE
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The purpose of this trial is to investigate the relative bioavailability of a BI 144807 tablet formulation compared to the oral solution formulation after single dose administration (intermediate and high dose) under fasted conditions. Further objectives are to assess whether and to what extent food affects single dose pharmacokinetics of BI 144807 administered as tablet, and to compare the relative bioavailability of two different tablet formulations.


Eligibility criteria: Inclusion criteria:

- Healthy male subjects

Exclusion criteria:

- Any relevant deviation from healthy condition

Primary outcomes:
measure: Area under the concentration-time curve of the analyte in plasma over the time interval from 0 to the last quantifiable data point (AUC0-tz)
timeFrame: 48 hours
measure: Maximum measured concentration of the analyte in plasma (Cmax)
timeFrame: 48 hours
Secondary outcomes:
measure: Area under the concentration-time curve of the analyte in plasma over the time interval from 0 extrapolated to infinity (AUC0-inf)
timeFrame: 48 hours
Other outcomes:
Locations:
city: Biberach
country: Germany
facility: 1313.9.1 Boehringer Ingelheim Investigational Site
Study officials:
affiliation: Boehringer Ingelheim
name: Boehringer Ingelheim
role: STUDY_CHAIR
References:
Clinical trial NCT05398497: FreezIng bReaST Cancer in Brazil: a Before-after Study
Official title: Evaluation of Cryoablation in the Local Treatment of Early Breast Cancer
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Breast Cancer
Breast Neoplasms
Keywords: cryoablation, cryotherapy, breast cancer
Lead sponsor: Hospital do Coracao
Sponsor class: OTHER
First posted: 2022-06-01
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Image-guided tumor ablation is a non-surgical, minimally invasive therapy available for local therapy of some carcinomas as an alternative to surgical treatment. This study assesses whether cryoablation can be used as an alternative to surgery in cases of early invasive breast carcinoma.

Detailed description: Purpose: To evaluate the effectiveness of cryoablation in the local treatment of breast cancer, through the absence of neoplastic cells (invasive or in situ).

Outline

1. Core biopsy
2. Mammogram
3. Magnetic resonance imaging
4. Ultrasound
5. Tumor Cryoablation
6. Mammogram (post-cryoablation)
7. Magnetic resonance imaging (post-cryoablation)
8. Ultrasound (post-cryoablation)
9. Surgery
10. Evaluation of outcomes

Eligibility criteria: Inclusion Criteria:

* Unifocal primary invasive breast carcinoma
* Pathological report should be complete (with the result of ER, PR , HER2, KI67 and FISH report of ERBB2 gene if necessary)
* Maximum tumor size ≤2.5 cm in its greatest diameter
* Ultrasound visible lesion

Exclusion Criteria:

* Multifocal or multicentric invasive breast carcinoma
* Ductal carcinoma in-situ
* Breast cancer with skin involvement
* Clinically positive axilla (N1, N2 or N3)
* Distance from lesion and skin less than 5 mm
* Prior neoadjuvant systemic therapy for breast cancer
* Distant metastasis

Primary outcomes:
measure: Tumor ablation
timeFrame: 1 month
Secondary outcomes:
measure: Negative predictive value of magnetic resonance imaging (MRI)
timeFrame: 14 days and 28 days
measure: Accuracy of conventional imaging methods (mammography and ultrasound)
timeFrame: 14 days and 28 days
measure: Measurement of the ice ball by ultrasound
timeFrame: 14 days and 28 days
Other outcomes:
Locations:
city: São Paulo
country: Brazil
facility: Hcor
state: SP
Study officials:
affiliation: Hospital do Coracao
name: Alexandre B Cavalcanti, PhD
role: STUDY_DIRECTOR
affiliation: Hospital do Coracao
name: Bruna MP Vianna
role: PRINCIPAL_INVESTIGATOR
affiliation: Hospital do Coracao
name: Vanessa M Sanvido, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Hospital do Coracao
name: Afonso CP Nazário, Professor
role: PRINCIPAL_INVESTIGATOR
References: