Clinical trial NCT06052059: A Study to Evaluate Efficacy and Safety of Tulisokibart (MK-7240) in Participants With Moderately to Severely Active Ulcerative Colitis (MK-7240-001)
Official title: A Phase 3, Randomized, Double-Blind, Placebo-Controlled Program to Evaluate the Efficacy and Safety of MK-7240 in Participants With Moderately to Severely Active Ulcerative Colitis
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE3
Conditions: Ulcerative Colitis
Keywords: Inflammatory Bowel Disease
Lead sponsor: Merck Sharp & Dohme LLC
Sponsor class: INDUSTRY
Collaborators: name: PPD, Part of Thermo Fisher Scientific
First posted: 2023-09-25
Enrollment: 1020
Sex: ALL
Minimum age (years): 16
Maximum age (years): 80
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this protocol is to evaluate the efficacy of tulisokibart in participants with moderately to severely active ulcerative colitis. Study 1's primary hypotheses are that at least 1 tulisokibart dose level is superior to Placebo in the proportion of participants achieving clinical remission according to the Modified Mayo Score at Week 12, and that at least 1 tulisokibart dose level is superior to Placebo in the proportion of participants achieving clinical remission according to the Modified Mayo Score at week 52. Study 2's primary hypothesis is that at least 1 tulisokibart dose level is superior to Placebo in the proportion of participants achieving clinical remission according to the Modified Mayo Score at Week 12.

Detailed description: The protocol consists of 2 studies. Study 1 includes induction and maintenance treatment, and Study 2 includes only induction treatment. Each study has its own hypotheses and outcome measures that will be assessed independently.

Eligibility criteria: Inclusion Criteria:

* Has had ulcerative colitis (UC) (from onset of symptoms) for at least 3 months before randomization
* Has moderately to severely active UC
* Weight ≥40 kg
* Satisfies at least 1 of the following criteria:

  * Has had an inadequate response or loss of response to 1 or more protocol-specified UC treatments
  * Protocol specified corticosteroid dependence
  * Has been intolerant to 1 or more protocol-specified UC treatments
* Is on treatment with any protocol-specified drugs during the study and meets drug stabilization requirements, as applicable
* Adolescent participants ≥16 and \<18 years of age can participate if approved by the country or regulatory/health authority
* A participant assigned female sex at birth is eligible to participate if not pregnant or breastfeeding and Is not a participant of childbearing potential (POCBP); or is a POCBP and uses an acceptable contraceptive method, or is abstinent from penile-vaginal intercourse as their preferred and usual lifestyle (abstinent on a long-term and persistent basis), has a negative highly sensitive pregnancy test (urine or serum) as required by local regulations within 24 hours (for a urine test) or 72 hours (for a serum test) before the first dose of study intervention, medical history, menstrual history, and recent sexual activity has been reviewed by the investigator to decrease the risk for inclusion of a POCBP with an early undetected pregnancy

Exclusion Criteria:

* Has a diagnosis of Crohn's Disease (CD) or indeterminate colitis (inflammatory bowel disease (IBD)-undefined) or other types of colitis or enteritis that may confound efficacy assessment.
* Has a current diagnosis of fulminant colitis and/or toxic megacolon
* Has UC limited to the rectum (i.e, must have evidence of UC extending beyond the rectosigmoid junction, which is \~10 cm from the anal margin)
* Has a current or impending need for colostomy or ileostomy
* Has had a total proctocolectomy or partial colectomy
* Has received fecal microbial transplantation within 4 weeks before randomization
* Has had UC exacerbation requiring hospitalization within 2 weeks before screening
* Has prior or current evidence of definite colonic dysplasia except for low-grade dysplasia that has been completely removed
* Has any active or serious infections without resolution after adequate treatment
* Has had cytomegalovirus infection that resolved less than 4 weeks before screening
* Has a transplanted organ which requires continued immunosuppression
* Has a history of cancer (except fully treated non-melanoma skin cell cancers or cervical carcinoma in situ after complete surgical removal) within the last 5 years
* Is known to be infected with hepatitis B virus (HBV), hepatitis C virus (HCV), or human immunodeficiency virus (HIV)
* Has evidence of active tuberculosis (TB), latent TB not successfully treated (per local guidelines), or inadequately treated TB (for participants with history of TB)
* Has confirmed or suspected COVID-19
* Has a history of drug or alcohol abuse within 6 months prior to screening
* Has had major surgery within 3 months before screening or has a major surgery planned during the study
* Is currently receiving or is planning to receive total parenteral nutrition at any time during study treatment
* Has received UC-related antibiotics and has not been on stable doses for at least 14 days before randomization or has discontinued these medications within 14 days of randomization
* Requires treatment with a therapy that does not adhere to the protocol-specified guidance parameters
* Has received protocol-specified prohibited medications
* Has had prior exposure to tulisokibart or another anti-tumor necrosis factor-like cytokine 1A (TL1A) antibody

Primary outcomes:
measure: Study 1: Percentage of Participants Achieving Clinical Remission Per Modified Mayo Score (MMS) at Week 12
timeFrame: Week 12
measure: Study 1: Percentage of Participants Achieving Clinical Remission Per MMS at Week 52
timeFrame: Week 52
measure: Study 2: Percentage of Participants Achieving Clinical Remission Per MMS at Week 12
timeFrame: Week 12
Secondary outcomes:
measure: Study 1: Percentage of Participants With One or More Adverse Events (AEs)
timeFrame: Up to approximately 52 weeks
measure: Study 1: Percentage of Participants Who Discontinued Study Intervention Due to an AE
timeFrame: Up to approximately 52 weeks
measure: Study 1: Percentage of Participants Achieving Clinical Response Per Partial Modified Mayo Score (pMMS) at Week 2
timeFrame: Week 2
measure: Study 1: Percentage of Participants With Endoscopic Improvement at Week 12
timeFrame: Week 12
measure: Study 1: Percentage of Participants Achieving a Clinical Response Per MMS at Week 12
timeFrame: Week 12
measure: Study 1: Percentage of Participants Achieving Histologic-Endoscopic Mucosal Improvement (HEMI) at Week 12
timeFrame: Week 12
measure: Study 1: Percentage of Participants Achieving Clinical Remission Per pMMS at Week 12
timeFrame: Week 12
measure: Study 1: Percentage of Participants With Endoscopic Remission at Week 12
timeFrame: Week 12
measure: Study 1: Percentage of Participants Reporting No Bowel Urgency at Week 12
timeFrame: Week 12
measure: Study 1: Percentage of Participants Reporting No Abdominal Pain at Week 12
timeFrame: Week 12
measure: Study 1: Percentage of Participants Achieving Inflammatory Bowel Disease Questionnaire (IBDQ) Remission at Week 12
timeFrame: Week 12
measure: Study 1: Change from Baseline in Functional Assessment of Chronic Illness Therapy - Fatigue (FACIT-Fatigue) Score at Week 12
timeFrame: Baseline and Week 12
measure: Percentage of Diagnostic Assay Positive (Dx+) Participants Achieving Clinical Remission Per MMS at Week 12
timeFrame: Week 12
measure: Percentage of Dx+ Participants With Endoscopic Improvement at Week 12
timeFrame: Week 12
measure: Study 1: Percentage of Participants Achieving Histologic-Endoscopic Remission (HER) at Week 12
timeFrame: Week 12
measure: Study 1: Percentage of Participants with Endoscopic Improvement at Week 52
timeFrame: Week 52
measure: Study 1: Percentage of Participants Achieving Corticosteroid-Free Clinical Remission Per MMS at Week 52
timeFrame: Week 52
measure: Study 1: Percentage of Participants Achieving HEMI at Week 52
timeFrame: Week 52
measure: Study 1: Percentage of Participants Achieving Clinical Remission Per pMMS at Week 52
timeFrame: Week 52
measure: Study 1: Percentage of Participants Achieving Sustained Clinical Remission Per MMS at Both Week 12 and Week 52
timeFrame: Week 12 and Week 52
measure: Study 1: Percentage of Participants Reporting No Bowel Urgency at Week 52
timeFrame: Week 52
measure: Study 1: Percentage of Participants Reporting No Abdominal Pain at Week 52
timeFrame: Week 52
measure: Study 1: Percentage of Participants With Endoscopic Remission at Week 52
timeFrame: Week 52
measure: Study 1: Percentage of Participants with Sustained Endoscopic Improvement at Both Week 12 and Week 52
timeFrame: Week 12 and Week 52
measure: Study 1: Percentage of Participants Achieving HER at Week 52
timeFrame: Week 52
measure: Study 1: Percentage of Participants Achieving IBDQ Remission at Week 52
timeFrame: Week 52
measure: Study 1: Change from Baseline in FACIT-Fatigue Score at Week 52
timeFrame: Baseline and Week 52
measure: Study 1: Percentage of Dx+ Participants Achieving Clinical Remission Per MMS at Week 52
timeFrame: Week 52
measure: Study 1: Percentage of Dx+ Participants With Endoscopic Improvement at Week 52
timeFrame: Week 52
measure: Study 2: Percentage of Participants With One or More AEs
timeFrame: Up to approximately 12 weeks
measure: Study 2: Percentage of Participants Who Discontinued Study Intervention Due to an AE
timeFrame: Up to approximately 12 weeks
measure: Study 2: Percentage of Participants with Clinical Response Per pMMS at Week 2
timeFrame: Week 2
measure: Study 2: Percentage of Participants With Endoscopic Improvement at Week 12
timeFrame: Week 12
measure: Study 2: Percentage of Participants Achieving a Clinical Response Per MMS at Week 12
timeFrame: Week 12
measure: Study 2: Percentage of Participants Achieving HEMI at Week 12
timeFrame: Week 12
measure: Study 2: Percentage of Participants Achieving Clinical Remission Per pMMS at Week 12
timeFrame: Week 12
measure: Study 2: Percentage of Participants With Endoscopic Remission at Week 12
timeFrame: Week 12
measure: Study 2: Percentage of Participants Reporting No Bowel Urgency at Week 12
timeFrame: Week 12
measure: Study 2: Percentage of Participants Reporting No Abdominal Pain at Week 12
timeFrame: Week 12
measure: Study 2: Percentage of Participants Achieving IBDQ Remission at Week 12
timeFrame: Week 12
measure: Study 2: Change from Baseline in FACIT-Fatigue Score at Week 12
timeFrame: Baseline and Week 12
measure: Study 2: Percentage of Participants Achieving HER at Week 12
timeFrame: Week 12
Other outcomes:
Locations:
city: Dothan
country: United States
facility: Digestive Health Specialists ( Site 0135)
state: Alabama
city: Fairhope
country: United States
facility: IMC-Gulf Coast Gastroenterology ( Site 0157)
state: Alabama
city: Litchfield Park
country: United States
facility: Research Solutions of Arizona ( Site 3816)
state: Arizona
city: Scottsdale
country: United States
facility: One of a Kind Clinical Research Center ( Site 3852)
state: Arizona
city: Sun City
country: United States
facility: GI Alliance - Sun City ( Site 0103)
state: Arizona
city: Anaheim
country: United States
facility: Clinnova Research ( Site 3803)
state: California
city: Coronado
country: United States
facility: Southern California Research Center ( Site 3828)
state: California
city: La Jolla
country: United States
facility: UCSD - Altman Clinical and Translational Research Institute (ACTRI) ( Site 0113)
state: California
city: Los Angeles
country: United States
facility: Cedars-Sinai Medical Center ( Site 0119)
state: California
city: Aurora
country: United States
facility: University of Colorado Anschutz Medical Campus-Division of Gastroenterology and Hepatology ( Site 0172)
state: Colorado
city: Colorado Springs
country: United States
facility: Peak Gastroenterology Associates ( Site 0116)
state: Colorado
city: Englewood
country: United States
facility: South Denver Gastroenterology, PC ( Site 3849)
state: Colorado
city: Littleton
country: United States
facility: Rocky Mountain Gastroenterology/Topography Health ( Site 3838)
state: Colorado
city: Bristol
country: United States
facility: Connecticut Clinical Research Institute ( Site 0126)
state: Connecticut
city: Hamden
country: United States
facility: Medical Research Center of Connecticut ( Site 0151)
state: Connecticut
city: New Haven
country: United States
facility: Yale University School of Medicine-Digestive Disease ( Site 0163)
state: Connecticut
city: Washington
country: United States
facility: Emerson Clinical Research Institute ( Site 3820)
state: District of Columbia
city: Clearwater
country: United States
facility: Gastroenterology Consultants of Clearwater ( Site 0152)
state: Florida
city: Gainesville
country: United States
facility: University of Florida College of Medicine-Gastroenterology ( Site 3821)
state: Florida
city: Inverness
country: United States
facility: Nature Coast Clinical Research - Inverness ( Site 3806)
state: Florida
city: Kissimmee
country: United States
facility: Central Florida Gastro Research ( Site 0124)
state: Florida
city: Orlando
country: United States
facility: Orlando Health ( Site 0145)
state: Florida
city: Tampa
country: United States
facility: USF Health ( Site 0169)
state: Florida
city: Atlanta
country: United States
facility: Emory University School of Medicine ( Site 3818)
state: Georgia
city: Atlanta
country: United States
facility: Atlanta Gastroenterology Associates - Peachtree Dunwoody ( Site 0115)
state: Georgia
city: Decatur
country: United States
facility: Atlanta Center for Gastroenterology ( Site 0155)
state: Georgia
city: Chicago
country: United States
facility: University of Chicago Medical Center ( Site 0134)
state: Illinois
city: Glenview
country: United States
facility: GI Alliance - Glenview ( Site 0168)
state: Illinois
city: Gurnee
country: United States
facility: GI ALLIANCE - GURNEE ( Site 0107)
state: Illinois
city: Clive
country: United States
facility: Iowa Digestive Disease Center ( Site 0123)
state: Iowa
city: Louisville
country: United States
facility: University of Louisville Hospital-Clinical Trials Unit ( Site 0165)
state: Kentucky
city: Baton Rouge
country: United States
facility: Baton Rouge General Medical Center - Bluebonnet ( Site 0112)
state: Louisiana
city: New Orleans
country: United States
facility: Tulane University School of Medicine-Gastroenterology and Hepatology ( Site 0154)
state: Louisiana
city: Glen Burnie
country: United States
facility: Woodholme Gastroenterology Associates-Woodholme Gastroenterology Associates ( Site 3835)
state: Maryland
city: Boston
country: United States
facility: Massachusetts General Hospital-Crohn's and Colitis Center ( Site 0132)
state: Massachusetts
city: Ann Arbor
country: United States
facility: University of Michigan ( Site 0143)
state: Michigan
city: Clinton Township
country: United States
facility: Clinical Research Institute of Michigan, LLC ( Site 0108)
state: Michigan
city: Farmington Hills
country: United States
facility: Michigan Center of Medical Research (MICHMER) ( Site 3850)
state: Michigan
city: Troy
country: United States
facility: Clinical Research Institute of Michigan, LLC ( Site 0150)
state: Michigan
city: Ypsilanti
country: United States
facility: Huron Gastroenterology ( Site 3836)
state: Michigan
city: Rochester
country: United States
facility: Mayo Clinic in Rochester, Minnesota ( Site 0147)
state: Minnesota
city: Liberty
country: United States
facility: BVL Research - Kansas ( Site 3847)
state: Missouri
city: Saint Louis
country: United States
facility: Washington University School of Medicine ( Site 0129)
state: Missouri
city: Middletown
country: United States
facility: Circuit Clinical /Middletown Medical PC ( Site 3831)
state: New York
city: New York
country: United States
facility: NYU Langone Health - Inflammatory Bowel Disease Center (IBD) ( Site 3846)
state: New York
city: New York
country: United States
facility: Lenox Hill Hospital ( Site 0128)
state: New York
city: New York
country: United States
facility: New York Gastroenterology Associates ( Site 0159)
state: New York
city: Chapel Hill
country: United States
facility: University of North Carolina Medical Center ( Site 0140)
state: North Carolina
city: Greenville
country: United States
facility: Carolina Digestive Diseases and Endoscopy Center ( Site 3809)
state: North Carolina
city: Philadelphia
country: United States
facility: Hospital of the University of Pennsylvania ( Site 0170)
state: Pennsylvania
city: Providence
country: United States
facility: University Gastroenterology ( Site 0164)
state: Rhode Island
city: Orangeburg
country: United States
facility: Gastroenterology Associates of Orangeburg ( Site 0149)
state: South Carolina
city: Nashville
country: United States
facility: Vanderbilt Inflammatory Bowel Disease Clinic ( Site 0131)
state: Tennessee
city: Nashville
country: United States
facility: Quality Medical Research ( Site 3807)
state: Tennessee
city: Garland
country: United States
facility: GI Alliance - Garland ( Site 0109)
state: Texas
city: Houston
country: United States
facility: Baylor College of Medicine Medical Center ( Site 3812)
state: Texas
city: Houston
country: United States
facility: The University of Texas Health Science Center at Houston-Internal Medicine-Division of Gastroentero ( Site 0144)
state: Texas
city: Houston
country: United States
facility: Clinical Trial Network ( Site 3819)
state: Texas
city: Lubbock
country: United States
facility: GI Alliance - Lubbock ( Site 0167)
state: Texas
city: Lubbock
country: United States
facility: Caprock Gastro Research ( Site 0101)
state: Texas
city: Mansfield
country: United States
facility: GI Alliance: Mansfield ( Site 0161)
state: Texas
city: San Antonio
country: United States
facility: CARTA - Clinical Associates In Research Therapeutics Of America ( Site 0122)
state: Texas
city: San Antonio
country: United States
facility: Southern Star Research Institute ( Site 0106)
state: Texas
city: San Marcos
country: United States
facility: GI Alliance - San Marcos ( Site 0130)
state: Texas
city: Southlake
country: United States
facility: GI Alliance - Southlake ( Site 0104)
state: Texas
city: Tyler
country: United States
facility: Tyler Research Institute ( Site 0105)
state: Texas
city: Webster
country: United States
facility: Texas Digestive Disease Consultants ( Site 0136)
state: Texas
city: West Jordan
country: United States
facility: Velocity Clinical Research, Salt Lake City ( Site 3801)
state: Utah
city: Richmond
country: United States
facility: Richmond VA Medical Center ( Site 3845)
state: Virginia
city: Bellevue
country: United States
facility: Washington Gastroenterology - Bellevue ( Site 3844)
state: Washington
city: Tacoma
country: United States
facility: Washington Gastroenterology - Tacoma ( Site 0102)
state: Washington
city: Milwaukee
country: United States
facility: MEDICAL COLLEGE OF WISCONSIN ( Site 0141)
state: Wisconsin
city: Mar del Plata
country: Argentina
facility: Centro de Investigaciones Médicas Mar del Plata ( Site 2101)
state: Buenos Aires
city: Quilmes
country: Argentina
facility: CER medical Institute-Gastroenterology ( Site 2110)
state: Caba
city: Rosario
country: Argentina
facility: Hospital Provincial del Centenario ( Site 2108)
state: Santa Fe
city: San Miguel de Tucumán
country: Argentina
facility: C.I.C.E. 9 de Julio-CICE 9 DE JULIO ( Site 2103)
state: Tucuman
city: Kingswood
country: Australia
facility: Nepean Hospital-Gastroenterology/Hepatology ( Site 2501)
state: New South Wales
city: Sydney
country: Australia
facility: Concord Repatriation General Hospital-Gastroenterology and Liver Services ( Site 2508)
state: New South Wales
city: Brisbane
country: Australia
facility: Royal Brisbane and Women's Hospital ( Site 2500)
state: Queensland
city: Brisbane
country: Australia
facility: Mater Misericordiae Limited-Gastroenterology ( Site 2506)
state: Queensland
city: Adelaide
country: Australia
facility: Royal Adelaide Hospital-Gastroenterology/Hepatology ( Site 2504)
state: South Australia
city: Clayton
country: Australia
facility: Monash Health-Gastroenterology ( Site 2505)
state: Victoria
city: Melbourne
country: Australia
facility: The Alfred Hospital-Gastroenterology ( Site 2503)
state: Victoria
city: Melbourne
country: Australia
facility: St Vincent's Hospital ( Site 2510)
state: Victoria
city: Innsbruck
country: Austria
facility: Universitaetsklinik fuer Innere Medizin I Innsbruck ( Site 0200)
state: Tirol
city: Vienna
country: Austria
facility: Medizinische Universität Wien-Klinik für Innere Medizin III - Abteilung für Gastroenterologie und H ( Site 0202)
state: Wien
city: Salzburg
country: Austria
facility: Uniklinikum Salzburg-Innere Medizin I ( Site 0201)
city: Gent
country: Belgium
facility: UZ Gent ( Site 0300)
state: Oost-Vlaanderen
city: Leuven
country: Belgium
facility: UZ Leuven-Gastroenterology - Inflammatory Bowel Disease ( Site 0301)
state: Vlaams-Brabant
city: Velingrad
country: Bulgaria
facility: MC Velingrad 2017 EOOD ( Site 0406)
state: Pazardzhik
city: Sofia
country: Bulgaria
facility: "Diagnostic - Consultative Center XX - Sofia" EOOD ( Site 0407)
state: Sofia (stolitsa)
city: Plovdiv
country: Bulgaria
facility: DKC V - Plovdiv ( Site 0402)
city: Ruse
country: Bulgaria
facility: MC Rusemed ( Site 0408)
city: Sliven
country: Bulgaria
facility: MHAT Hadzhi Dimitar-Gastroenterology ( Site 0403)
city: Sofia
country: Bulgaria
facility: Diagnostic Consultative Center 22 - Sofia ( Site 0401)
city: Sofia
country: Bulgaria
facility: 4th MHAT ( Site 0409)
city: Veliko Tarnovo
country: Bulgaria
facility: Medica Plus Medical Center ( Site 0404)
city: Calgary
country: Canada
facility: Heritage Medical Research Clinic ( Site 0004)
state: Alberta
city: Lethbridge
country: Canada
facility: SIX08 Gastroenterology ( Site 0013)
state: Alberta
city: Vancouver
country: Canada
facility: G.I.R.I. GI Research Institute Foundation ( Site 0001)
state: British Columbia
city: Barrie
country: Canada
facility: Barrie GI Associates ( Site 0012)
state: Ontario
city: London
country: Canada
facility: University Hospital - London Health Sciences Centre ( Site 0002)
state: Ontario
city: London
country: Canada
facility: Victoria Hospital & Children's Hospital - London Health Sciences Centre ( Site 0007)
state: Ontario
city: Mississauga
country: Canada
facility: West GTA Research Inc. ( Site 0017)
state: Ontario
city: Toronto
country: Canada
facility: Toronto Immune & Digestive Health Institute ( Site 0005)
state: Ontario
city: Vaughan
country: Canada
facility: Toronto Digestive Disease Associates ( Site 0006)
state: Ontario
city: Levis
country: Canada
facility: Centre Intégré de Santé et Service Sociaux de Chaudière-Appalaches ( Site 0015)
state: Quebec
city: Montreal
country: Canada
facility: Montreal General Hospital ( Site 0003)
state: Quebec
city: Ontario
country: Canada
facility: ABP Research Services Corp. ( Site 0016)
city: Quebec
country: Canada
facility: Diex Recherche Quebec ( Site 0008)
city: Valdivia
country: Chile
facility: Clinical Research Chile SpA ( Site 2201)
state: Los Rios
city: Santiago.
country: Chile
facility: Centro de Estudios Clínicos SAGA-CECSAGA ( Site 2203)
state: Region M. De Santiago
city: Santiago
country: Chile
facility: FALP-UIDO ( Site 2208)
state: Region M. De Santiago
city: Santiago
country: Chile
facility: Clínica Universidad de Los Andes ( Site 2202)
state: Region M. De Santiago
city: Santiago
country: Chile
facility: Clínica Alemana de Santiago ( Site 2209)
state: Region M. De Santiago
city: Santiago
country: Chile
facility: Clínica MEDS La Dehesa ( Site 2207)
state: Region M. De Santiago
city: Santiago
country: Chile
facility: CECIM ( Site 2200)
state: Region M. De Santiago
city: Santiago
country: Chile
facility: Pontificia Universidad Catolica de Chile-CICUC ( Site 2205)
state: Region M. De Santiago
city: Hefei
country: China
facility: The First Affiliated Hospital of Anhui Medical University ( Site 3957)
state: Anhui
city: Hefei
country: China
facility: Anhui Provincial Hospital ( Site 3947)
state: Anhui
city: Beijing
country: China
facility: Beijing Friendship Hospital Affiliate of Capital University ( Site 3923)
state: Beijing
city: Beijing
country: China
facility: Peking University Third Hospital ( Site 3909)
state: Beijing
city: Beijing
country: China
facility: Beijing Luhe Hospital Capital Medical University ( Site 3911)
state: Beijing
city: Chongqing
country: China
facility: Chongqing University Three Gorges Hospital ( Site 3928)
state: Chongqing
city: Fuzhou
country: China
facility: The First Affiliated Hospital Of Fujian Medical University ( Site 3904)
state: Fujian
city: Xiamen
country: China
facility: The First Affiliated hospital of Xiamen University-Gastroenterology ( Site 3954)
state: Fujian
city: Dongguan
country: China
facility: Dongguan People's Hospital-Gastroenterology department ( Site 3944)
state: Guangdong
city: Guangzhou
country: China
facility: Guangzhou Medical University 2nd Hospital ( Site 3908)
state: Guangdong
city: Guangzhou
country: China
facility: Southern Medical University Nanfang Hospital-Gastroenterology ( Site 3914)
state: Guangdong
city: Guangzhou
country: China
facility: The Sixth Affiliated Hospital of Sun Yat-sen University ( Site 3906)
state: Guangdong
city: Huizhou
country: China
facility: Huizhou Municipal Central Hospital ( Site 3917)
state: Guangdong
city: Shaoguan
country: China
facility: Yuebei People's Hospital Guangdong ( Site 3948)
state: Guangdong
city: Shenzhen
country: China
facility: The University of Hong Kong-Shenzhen Hospital ( Site 3955)
state: Guangdong
city: Shenzhen
country: China
facility: Shenzhen Hospital of Southern Medical University-Gastroenterology department ( Site 3905)
state: Guangdong
city: Shijiazhuang
country: China
facility: The Second Hospital of Hebei Medical University ( Site 3934)
state: Hebei
city: Zhengzhou
country: China
facility: The Second Affiliated Hospital of Zhengzhou University ( Site 3935)
state: Henan
city: Shiyan
country: China
facility: Taihe Hospital ( Site 3941)
state: Hubei
city: Wuhan
country: China
facility: The Central Hospital of Wuhan ( Site 3939)
state: Hubei
city: Wuhan
country: China
facility: Renmin Hospital of Wuhan University ( Site 3912)
state: Hubei
city: Changsha
country: China
facility: The Second Xiangya Hospital of Central South University ( Site 3930)
state: Hunan
city: Changzhou
country: China
facility: Changzhou No.2 People's Hospital ( Site 3950)
state: Jiangsu
city: NanJing
country: China
facility: Nanjing Drum Tower Hospital The Affiliated Hospital of Nanjing University Medical School ( Site 3900)
state: Jiangsu
city: Nanjing
country: China
facility: Zhongda Hospital Southeast University ( Site 3919)
state: Jiangsu
city: Wuxi
country: China
facility: Wuxi People's Hospital ( Site 3920)
state: Jiangsu
city: Nanchang
country: China
facility: The First Affiliated Hospital of Nanchang University ( Site 3926)
state: Jiangxi
city: Xian
country: China
facility: Tangdu Hospital of Fourth Military Medical University of Chinese People's Liberation Army ( Site 3929)
state: Shaanxi
city: Binzhou
country: China
facility: Binzhou Medical University Hospital ( Site 3953)
state: Shandong
city: Taian
country: China
facility: Taian City Central Hospital-gastroenterology department ( Site 3946)
state: Shandong
city: Shanghai
country: China
facility: Ruijin Hospital Shanghai Jiaotong University School of Medicine-Gastroneterology ( Site 3903)
state: Shanghai
city: Shanghai
country: China
facility: Shanghai East Hospital ( Site 3922)
state: Shanghai
city: Shanghai
country: China
facility: Renji Hospital Shanghai Jiao Tong University School of Medicine ( Site 3915)
state: Shanghai
city: Cheng Du
country: China
facility: West China Hospital, Sichuan University ( Site 3951)
state: Sichuan
city: Tianjin
country: China
facility: Tianjin Medical University General Hospital ( Site 3945)
state: Tianjin
city: Urumqi
country: China
facility: The First Teaching Hospital of Xinjiang Medical University. ( Site 3937)
state: Xinjiang
city: Kunming
country: China
facility: First Affiliated Hospital of Kunming Medical University ( Site 3925)
state: Yunnan
city: Hangzhou
country: China
facility: Sir Run Run Shaw Hospital of Zhejiang University School of Medicine-GI Medicine ( Site 3916)
state: Zhejiang
city: Medellín
country: Colombia
facility: Clínica las Américas ( Site 2318)
state: Antioquia
city: Medellín
country: Colombia
facility: Clinica Medellin S.A ( Site 2317)
state: Antioquia
city: Rionegro
country: Colombia
facility: Clinica Somer-Unidad de Investigacion y Docencia ( Site 2303)
state: Antioquia
city: Barranquilla
country: Colombia
facility: Clinica de la Costa S.A.S. ( Site 2305)
state: Atlantico
city: Bogota
country: Colombia
facility: Fundacion Santa Fe de Bogota ( Site 2316)
state: Cundinamarca
city: Pereira.
country: Colombia
facility: Oncologos del Occidente ( Site 2310)
state: Risaralda
city: Cali
country: Colombia
facility: Fundación Valle del Lili ( Site 2307)
state: Valle Del Cauca
city: Zagreb
country: Croatia
facility: Klinička bolnica Merkur ( Site 0505)
state: Grad Zagreb
city: Zagreb
country: Croatia
facility: Klinički bolnički centar Zagreb ( Site 0501)
state: Grad Zagreb
city: Zagreb
country: Croatia
facility: Poliklinika Bates ( Site 0504)
state: Grad Zagreb
city: Zagreb
country: Croatia
facility: Poliklinika Solmed ( Site 0502)
state: Grad Zagreb
city: Osijek
country: Croatia
facility: Poliklinika Borzan ( Site 0500)
state: Osjecko-baranjska Zupanija
city: Split
country: Croatia
facility: Klinički Bolnički Centar Split ( Site 0503)
state: Splitsko-dalmatinska Zupanija
city: Brno
country: Czechia
facility: Vojenská Nemocnice Brno-Internal department ( Site 0605)
state: Brno-mesto
city: Praha
country: Czechia
facility: Institut Klinicke a Experimentalni Mediciny-Klinika hepatogastroentrologie ( Site 0604)
state: Praha 4
city: Slany
country: Czechia
facility: Nemocnice Slany ( Site 0601)
state: Stredocesky Kraj
city: Hradec Kralove
country: Czechia
facility: Hepato-Gastroenterologie HK ( Site 0602)
city: Santo Domingo
country: Dominican Republic
facility: CEMDOE - Centro Médico de Diabetes, Obesidad y Especialidades ( Site 3601)
state: Distrito Nacional
city: Tampere
country: Finland
facility: Tampereen yliopistollinen sairaala ( Site 4300)
state: Pirkanmaa
city: Joensuu
country: Finland
facility: Pohjois-Karjalan keskussairaala ( Site 4302)
state: Pohjois-Karjala
city: Turku
country: Finland
facility: Turku University Hospital ( Site 4301)
state: Varsinais-Suomi
city: Nice
country: France
facility: Centre Hospitalier Universitaire de Nice - Hôpital l'Archet ( Site 0706)
state: Alpes-Maritimes
city: Pessac
country: France
facility: CHU Bordeaux Haut-Leveque-Service d'Hépato-gastroentérologie ( Site 0700)
state: Aquitaine
city: Marseille
country: France
facility: Assistance Publique Hôpitaux de Marseille - Hôpital Nord ( Site 0714)
state: Bouches-du-Rhone
city: Reims
country: France
facility: Centre Hospitalier Universitaire de Reims - Hôpital Robert Debré ( Site 0705)
state: Champagne-Ardenne
city: Besançon
country: France
facility: CHU Besançon ( Site 0710)
state: Doubs
city: Nimes
country: France
facility: C.H.U. de Nimes. Hopital Caremeau ( Site 0718)
state: Gard
city: Clichy
country: France
facility: Hopital Beaujon ( Site 0716)
state: Hauts-de-Seine
city: Neuilly-sur-Seine
country: France
facility: CMC Ambroise Paré Hartmann - Institut des MICI ( Site 0709)
state: Hauts-de-Seine
city: Montpellier
country: France
facility: CHU SAINT ELOI ( Site 0711)
state: Languedoc-Roussillon
city: Nantes
country: France
facility: Centre Hospitalier Universitaire de Nantes - L' Hopital l'hôtel-Dieu ( Site 0701)
state: Loire-Atlantique
city: Vandoeuvre lès Nancy
country: France
facility: Centre Hospitalier Régional Universitaire de Nancy - Hôpitaux de Brabois ( Site 0708)
state: Meurthe-et-Moselle
city: Pierre-Bénite
country: France
facility: centre hospitalier lyon sud ( Site 0707)
state: Rhone
city: Amiens
country: France
facility: CHU d'Amiens-Picardie - Hôpital Sud-Hepato-gastroentérology ( Site 0712)
state: Somme
city: Creteil
country: France
facility: Hopital Henri Mondor ( Site 0717)
state: Val-de-Marne
city: Le Kremlin-Bicêtre
country: France
facility: Hôpitaux Universitaires Paris Sud - Hôpital Bicêtre ( Site 0715)
state: Val-de-Marne
city: Paris
country: France
facility: Hôpital Saint Antoine ( Site 0703)
city: Paris
country: France
facility: Hôpital Saint-Louis ( Site 0702)
city: Batumi
country: Georgia
facility: LTD High Technology Hospital Medcenter ( Site 0802)
state: Ajaria
city: Tbilisi
country: Georgia
facility: Caraps Medline ( Site 0803)
city: Tbilisi
country: Georgia
facility: New Hospitals ( Site 0800)
city: Tbilisi
country: Georgia
facility: Caucasus Medical Centre ( Site 0801)
city: Ulm
country: Germany
facility: Universitaetsklinikum Ulm. ( Site 0902)
state: Baden-Wurttemberg
city: Munich
country: Germany
facility: Klinikum der Universität München Großhadern-Medizinische Klinik und Poliklinik II ( Site 0907)
state: Bayern
city: Frankfurt am Main
country: Germany
facility: Agaplesion Markus Krankenhaus ( Site 0904)
state: Hessen
city: Hannover
country: Germany
facility: Medizinische Hochschule Hannover ( Site 0913)
state: Niedersachsen
city: Lüneburg
country: Germany
facility: Klinikum Lüneburg ( Site 0908)
state: Niedersachsen
city: Duisburg
country: Germany
facility: Stadtische Kliniken Duisburg, Abtlg. Innere Medizin ( Site 0916)
state: Nordrhein-Westfalen
city: Minden
country: Germany
facility: Gastroenterologische Gemeinschaftspraxis Minden ( Site 0911)
state: Nordrhein-Westfalen
city: Münster
country: Germany
facility: Medizinisches Versorgungszentrum Portal 10 ( Site 0914)
state: Nordrhein-Westfalen
city: Ludwighafen Am Rhein
country: Germany
facility: St. Marien und St. Annastift Krankenhaus ( Site 0901)
state: Rheinland-Pfalz
city: Leipzig
country: Germany
facility: Universitätsklinikum Leipzig ( Site 0909)
state: Sachsen
city: Kiel
country: Germany
facility: Universitaetsklinikum Schleswig-Holstein Campus Kiel ( Site 0903)
state: Schleswig-Holstein
city: Berlin
country: Germany
facility: Charité Campus Virchow-Klinikum ( Site 0906)
city: Brandenburg
country: Germany
facility: Städtisches Klinikum Brandenburg ( Site 0905)
city: Athens
country: Greece
facility: Evangelismos General Hospital of Athens ( Site 4001)
state: Attiki
city: Athens
country: Greece
facility: THORACIC GENERAL HOSPITAL OF ATHENS "I SOTIRIA"-3rd Dept of Internal Medicine and Laboratory, Oncol ( Site 4000)
state: Attiki
city: Nikaia Piraeus
country: Greece
facility: General Hospital of Nikaia-Piraeus "Agios Panteleimon" ( Site 4006)
state: Attiki
city: Thessaloniki
country: Greece
facility: Ippokrateio General Hospital of Thessaloniki ( Site 4004)
state: Kentriki Makedonia
city: Heraklion
country: Greece
facility: University General Hospital of Heraklion-GASTROENTEROLOGY & HEPATOLOGY ( Site 4003)
state: Kriti
city: Kecskemét
country: Hungary
facility: Csőszi Endoszkópos KFT ( Site 1001)
state: Bacs-Kiskun
city: Mohács
country: Hungary
facility: Mohácsi Kórház ( Site 1008)
state: Baranya
city: Békéscsaba
country: Hungary
facility: Békés Megyei Központi Kórház Dr. Réthy Pál Tagkórház-4. Belgyogyaszat Gasztroenterologia ( Site 1007)
state: Bekescsaba
city: Eger
country: Hungary
facility: Heves Vármegyei Markhot Ferenc Oktatókórház és Rendelőintézet ( Site 1012)
state: Heves
city: Gyongyos
country: Hungary
facility: Gyöngyösi Bugát Pál Kórház ( Site 1011)
state: Heves
city: Tatabánya
country: Hungary
facility: Komarom-Esztergom Varmegyei Szent Borbala Korhaz ( Site 1010)
state: Komarom-Esztergom
city: Veszprém
country: Hungary
facility: VeszLife Magánklinika ( Site 1002)
state: Veszprem
city: Budapest
country: Hungary
facility: Synexus Magyarorszag Kft. (Budapest DRS) ( Site 1009)
city: Budapest
country: Hungary
facility: Semmelweis Egyetem ( Site 1006)
city: Budapest
country: Hungary
facility: Pannónia Magánorvosi Centrum ( Site 1004)
city: Afula
country: Israel
facility: Emek Medical Center ( Site 1106)
city: Ashkelon
country: Israel
facility: Barzilai Medical Center ( Site 1109)
city: Haifa
country: Israel
facility: Rambam Health Care Campus ( Site 1101)
city: Haifa
country: Israel
facility: Bnai Zion Medical Center ( Site 1103)
city: Holon
country: Israel
facility: Edith Wolfson Medical Center ( Site 1104)
city: Jerusalem
country: Israel
facility: Shaare Zedek Medical Center ( Site 1108)
city: Kfar Saba
country: Israel
facility: Meir Medical Center. ( Site 1102)
city: Petah Tikva
country: Israel
facility: Rabin Medical Center ( Site 1107)
city: Ramat Gan
country: Israel
facility: Sheba Medical Center ( Site 1100)
city: Monserrato
country: Italy
facility: Policlinico Universitario Monserrato-SC Gastroenterologia ( Site 1207)
state: Cagliari
city: San Giovanni Rotondo
country: Italy
facility: IRCCS Casa Sollievo della Sofferenza ( Site 1213)
state: Foggia
city: Rome
country: Italy
facility: Fondazione Policlinico Tor Vergata ( Site 1209)
state: Lazio
city: Milano
country: Italy
facility: Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico-Gastroenterology and Endoscopy Unit ( Site 1202)
state: Lombardia
city: Rozzano
country: Italy
facility: Istituto Clinico Humanitas-IBD center ( Site 1201)
state: Lombardia
city: Rho
country: Italy
facility: Ospedale Di Circolo-U.O.C. di Gastroenterologia ed Endoscopia Digestiva ( Site 1216)
state: Milano
city: Napoles
country: Italy
facility: A.O.R.N. Ospedale dei Colli - Monaldi V. ( Site 1217)
state: Napoli
city: Rome
country: Italy
facility: Azienda Ospedaliera San Camillo Forlanini ( Site 1204)
state: Roma
city: Rome
country: Italy
facility: Fatebenefratelli Isola Tiberina - Gemelli Isola ( Site 1214)
state: Roma
city: Palermo
country: Italy
facility: Az. Osp. Ospedali Riuniti VILLA SOFIA-CERVELLO-U.O.S.D. Malattie Infiammatorie Croniche Intestinali ( Site 1210)
state: Sicilia
city: Negrar
country: Italy
facility: Ospedale Sacro Cuore Don G. Calabria ( Site 1212)
state: Verona
city: Bologna
country: Italy
facility: IRCCS Azienda Ospedaliero-Universitaria di Bologna, Policlinico di Sant'Orsola ( Site 1208)
city: Milano
country: Italy
facility: ASST Fatebenefratelli Sacco-UOC Gastroenterologia ( Site 1200)
city: Milano
country: Italy
facility: Ospedale San Raffaele-Gastroenterology and Gastrointestinal Endoscopy ( Site 1205)
city: Pavia
country: Italy
facility: Fondazione IRCCS Policlinico San Matteo-General Medicine ( Site 1206)
city: Nagakute
country: Japan
facility: Aichi Medical University Hospital ( Site 2841)
state: Aichi
city: Abiko
country: Japan
facility: Tokatsu Tsujinaka Hospital ( Site 2832)
state: Chiba
city: Kashiwa
country: Japan
facility: Tsujinaka Hospital - Kashiwanoha ( Site 2802)
state: Chiba
city: Sakura
country: Japan
facility: Toho University Sakura Medical Center ( Site 2805)
state: Chiba
city: Matsuyama
country: Japan
facility: Ehime Prefectural Central Hospital ( Site 2868)
state: Ehime
city: Kitakyushu
country: Japan
facility: Kitakyushu Municipal Medical Center ( Site 2873)
state: Fukuoka
city: Kurume
country: Japan
facility: Kurume University Hospital ( Site 2846)
state: Fukuoka
city: Maebashi
country: Japan
facility: Gunma University Hospital ( Site 2850)
state: Gunma
city: Fukuyama
country: Japan
facility: National Hospital Organization Fukuyama Medical Center ( Site 2831)
state: Hiroshima
city: Asahikawa
country: Japan
facility: Asahikawa City Hospital ( Site 2840)
state: Hokkaido
city: Asahikawa
country: Japan
facility: Asahikawa Medical University Hospital ( Site 2815)
state: Hokkaido
city: Sapporo
country: Japan
facility: Sapporo Tokushukai Hospital ( Site 2808)
state: Hokkaido
city: Sapporo
country: Japan
facility: Sapporo Medical University Hospital ( Site 2829)
state: Hokkaido
city: Sapporo
country: Japan
facility: Medical Corporation Sapporo IBD Clinic ( Site 2842)
state: Hokkaido
city: Sapporo
country: Japan
facility: Sapporohigashi Tokushukai Hospital ( Site 2860)
state: Hokkaido
city: Nishinomiya
country: Japan
facility: Hyogo Medical University Hospital ( Site 2830)
state: Hyogo
city: Hitachi
country: Japan
facility: Hitachi General Hospital ( Site 2856)
state: Ibaraki
city: Kanazawa
country: Japan
facility: Ishikawa Prefectural Central Hospital ( Site 2835)
state: Ishikawa
city: Kanazawa
country: Japan
facility: Kanazawa University Hospital ( Site 2839)
state: Ishikawa
city: Morioka
country: Japan
facility: Iwate Medical University Uchimaru Medical Center ( Site 2833)
state: Iwate
city: Kamakura
country: Japan
facility: Gokeikai Ofuna Chuo Hospital ( Site 2801)
state: Kanagawa
city: Kawasaki
country: Japan
facility: St. Marianna University Hospital ( Site 2852)
state: Kanagawa
city: Yokohama
country: Japan
facility: Matsushima Hospital ( Site 2822)
state: Kanagawa
city: Yokohama
country: Japan
facility: Yokohama City University Medical Center ( Site 2865)
state: Kanagawa
city: Tsu
country: Japan
facility: Mie University Hospital ( Site 2838)
state: Mie
city: Fujiidera
country: Japan
facility: Sai Gastroenterology/Proctology Clinic ( Site 2814)
state: Osaka
city: Hirakata
country: Japan
facility: Kansai Medical University Hospital ( Site 2823)
state: Osaka
city: Hamamatsu
country: Japan
facility: Hamamatsu University Hospital ( Site 2874)
state: Shizuoka
city: Hamamatsu
country: Japan
facility: Matsuda Hospital ( Site 2826)
state: Shizuoka
city: Shimizu
country: Japan
facility: National Hospital Organization Shizuoka Medical Center ( Site 2837)
state: Shizuoka
city: Bunkyō
country: Japan
facility: Institute of Science Tokyo Hospital ( Site 2827)
state: Tokyo
city: Chuo
country: Japan
facility: Ginza Central Clinic ( Site 2824)
state: Tokyo
city: Minato-ku
country: Japan
facility: Toranomon Hospital ( Site 2828)
state: Tokyo
city: Minato-ku
country: Japan
facility: Kitasato University Kitasato Institute Hospital ( Site 2817)
state: Tokyo
city: Minato
country: Japan
facility: The Jikei University Hospital ( Site 2843)
state: Tokyo
city: Mitaka-shi
country: Japan
facility: Kyorin University Hospital ( Site 2804)
state: Tokyo
city: Shinagawa-ku
country: Japan
facility: NTT Medical Center Tokyo ( Site 2834)
state: Tokyo
city: Kofu
country: Japan
facility: Yamanashi Prefectural Central Hospital ( Site 2836)
state: Yamanashi
city: Fukui
country: Japan
facility: Fukui Prefectural Hospital ( Site 2844)
city: Fukuoka
country: Japan
facility: Fukuoka University Hospital ( Site 2818)
city: Hiroshima
country: Japan
facility: Hiroshima University Hospital ( Site 2845)
city: Kagoshima
country: Japan
facility: Kagoshima University Hospital ( Site 2848)
city: Kagoshima
country: Japan
facility: Kagoshima IBD Gastroenterology Clinic ( Site 2821)
city: Kyoto
country: Japan
facility: University Hospital,Kyoto Prefectural University of Medicine ( Site 2819)
city: Kyoto
country: Japan
facility: National Hospital Organization Kyoto Medical Center ( Site 2813)
city: Oita
country: Japan
facility: Ishida Clinic of IBD and Gastroenterology ( Site 2820)
city: Okayama
country: Japan
facility: Okayama University Hospital ( Site 2870)
city: Osaka
country: Japan
facility: Infusion Clinic ( Site 2806)
city: Osaka
country: Japan
facility: National Hospital Organization Osaka National Hospital ( Site 2869)
city: Saga
country: Japan
facility: Saga University Hospital ( Site 2812)
city: Saitama
country: Japan
facility: Tokitokai Tokito Clinic Coloproctology Center ( Site 2811)
city: Tokyo
country: Japan
facility: Tokyo Yamate Medical Center ( Site 2803)
city: Toyama
country: Japan
facility: Toyama Prefectural Central Hospital ( Site 2807)
city: Yamagata
country: Japan
facility: Yamagata University Hospital ( Site 2849)
city: Wonju
country: Korea, Republic of
facility: Wonju Severance Christian Hospital-Internal Medicine ( Site 3003)
state: Kang-won-do
city: Suwon-si
country: Korea, Republic of
facility: The Catholic University Of Korea St. Vincent's Hospital-Gastroenterology ( Site 3006)
state: Kyonggi-do
city: Busan
country: Korea, Republic of
facility: Dong-A University Hospital ( Site 3010)
state: Pusan-Kwangyokshi
city: Haeundae-gu
country: Korea, Republic of
facility: Inje University Haeundae Paik Hospital ( Site 3009)
state: Pusan-Kwangyokshi
city: Dongjak-gu
country: Korea, Republic of
facility: Chung-Ang University Hospital ( Site 3008)
state: Seoul
city: Daegu
country: Korea, Republic of
facility: Yeungnam University Medical Center ( Site 3004)
state: Taegu-Kwangyokshi
city: Daejeon
country: Korea, Republic of
facility: The Catholic University of Korea, Daejeon St. Mary's Hospital ( Site 3011)
state: Taejon-Kwangyokshi
city: Seoul
country: Korea, Republic of
facility: Kyung Hee University Hospital ( Site 3013)
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital ( Site 3005)
city: Seoul
country: Korea, Republic of
facility: Kangbuk Samsung Hospital-Internal Medicine ( Site 3002)
city: Seoul
country: Korea, Republic of
facility: The Catholic University of Korea, Eunpyeong St. Mary's Hospital ( Site 3012)
city: Seoul
country: Korea, Republic of
facility: Severance Hospital, Yonsei University Health System-Department of Internal Medicine ( Site 3000)
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center ( Site 3007)
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center ( Site 3001)
city: Adazi
country: Latvia
facility: SIA M & M Centrs ( Site 4502)
state: Adazu Novads
city: Liepaja
country: Latvia
facility: Liepaja Regional Hospital ( Site 4501)
city: Kaunas
country: Lithuania
facility: Hospital of Lithuanian University of Health Sciences Kauno klinikos ( Site 4600)
state: Kauno Apskritis
city: Vilnius
country: Lithuania
facility: VUL SANTAROS KLINIKOS ( Site 4601)
state: Vilniaus Miestas
city: León
country: Mexico
facility: Morales Vargas Centro de Investigacion ( Site 2411)
state: Guanajuato
city: Guadalajara
country: Mexico
facility: PanAmerican Clinical Research - Guadalajara ( Site 2400)
state: Jalisco
city: Tlajumulco De Zuniga
country: Mexico
facility: Centro Medico Clinico Quirurgico Especializado en Investigación ( Site 2403)
state: Jalisco
city: Merida
country: Mexico
facility: Centro Multidisciplinario para el Desarrollo Especializado de la Investigacion Clinica en Yucatan ( Site 2407)
state: Yucatan
city: Chihuahua
country: Mexico
facility: ICARO Investigaciones en Medicina ( Site 2405)
city: Mexico City
country: Mexico
facility: Centro de Investigación y Gastroenterología - S.C. ( Site 2410)
city: Oaxaca
country: Mexico
facility: Oaxaca Site Management Organization S.C. ( Site 2404)
city: Nijmegen
country: Netherlands
facility: Radboudumc ( Site 1402)
state: Gelderland
city: Tilburg
country: Netherlands
facility: ETZ Elisabeth-Department of Gastroenterology and Hepatology ( Site 1403)
state: Noord-Brabant
city: Uden
country: Netherlands
facility: Ziekenhuis Bernhoven-Researchbureau ( Site 1401)
state: Noord-Brabant
city: Amsterdam
country: Netherlands
facility: Onze Lieve Vrouwe Gasthuis ( Site 1405)
state: Noord-Holland
city: Amsterdam
country: Netherlands
facility: Amsterdam UMC, locatie VUmc-IBD Trial Unit ( Site 1400)
state: Noord-Holland
city: Deventer
country: Netherlands
facility: Deventer Ziekenhuis ( Site 1411)
state: Overijssel
city: Rotterdam
country: Netherlands
facility: Erasmus Medisch Centrum ( Site 1410)
state: Zuid-Holland
city: Rotterdam
country: Netherlands
facility: Franciscus Gasthuis & Vlietland, Locatie Gasthuis ( Site 1406)
state: Zuid-Holland
city: Utrecht
country: Netherlands
facility: Universitair Medisch Centrum Utrecht ( Site 1404)
city: Hamilton
country: New Zealand
facility: Waikato Hospital ( Site 2903)
state: Waikato
city: Lower Hutt
country: New Zealand
facility: Hutt Valley District Health board HVDHB ( Site 2902)
state: Wellington
city: Auckland
country: New Zealand
facility: Aotearoa Clinical Trials ( Site 2900)
city: Lørenskog
country: Norway
facility: Akershus Universitetssykehus ( Site 4200)
state: Akershus
city: Oslo
country: Norway
facility: Oslo Universitetssykehus Ullevål ( Site 4201)
city: Wroclaw
country: Poland
facility: Planetmed ( Site 1506)
state: Dolnoslaskie
city: Wroclaw
country: Poland
facility: Melita Medical ( Site 1519)
state: Dolnoslaskie
city: Wroclaw
country: Poland
facility: EMC Instytut Medyczny SA ( Site 1505)
state: Dolnoslaskie
city: Torun
country: Poland
facility: Gastromed Sp. z o. o. ( Site 1513)
state: Kujawsko-pomorskie
city: Lodz
country: Poland
facility: Med-Gastr Sp. z o.o., sp.k ( Site 1515)
state: Lodzkie
city: Lodz
country: Poland
facility: AmiCare Centrum Medyczne - Zgierska ( Site 1517)
state: Lodzkie
city: Nowy Targ
country: Poland
facility: Allmedica ( Site 1508)
state: Malopolskie
city: Warsawa
country: Poland
facility: Vivamed Sp. z o.o. ( Site 1510)
state: Mazowieckie
city: Warszawa
country: Poland
facility: Centrum Zdrowia MDM ( Site 1512)
state: Mazowieckie
city: Warszawa
country: Poland
facility: WIP Warsaw IBD Point Profesor Kierkuś ( Site 1503)
state: Mazowieckie
city: Szczecin
country: Poland
facility: Twoja Przychodnia - Szczecinskie Centrum Medyczne ( Site 1502)
state: Zachodniopomorskie
city: Szczecin
country: Poland
facility: Sonomed Sp. z o. o. ( Site 1516)
state: Zachodniopomorskie
city: Lisbon
country: Portugal
facility: Unidade Local de Saude Lisboa Ocidental - Hospital Egas Moniz ( Site 3306)
state: Lisboa
city: Braga
country: Portugal
facility: Unidade Local de Saude de Braga - Hospital de Braga ( Site 3300)
city: Lisboa
country: Portugal
facility: Hospital dos Lusíadas Lisboa ( Site 3303)
city: Lisboa
country: Portugal
facility: Unidade Local de Saude de Santa Maria - Hospital de Santa Maria ( Site 3305)
city: Viana do Castelo
country: Portugal
facility: ULSAM - Hospital de Santa Luzia ( Site 3302)
city: Viseu
country: Portugal
facility: Unidade Local de Saude Dão-Lafões - Hospital de São Teotónio ( Site 3308)
city: Bucharest
country: Romania
facility: MEMORIAL HEALTHCARE INTERNATIONAL S.R.L ( Site 1606)
state: Bucuresti
city: București
country: Romania
facility: Fundeni Clinical Institute-Gastroenterology and Hepatology Center ( Site 1608)
state: Bucuresti
city: Cluj Napoca
country: Romania
facility: Spitalul Clinic Judetean de Urgenta Cluj Napoca-Gastroenterology ( Site 1605)
state: Cluj
city: Cluj-Napoca
country: Romania
facility: GastroMed ( Site 1609)
state: Cluj
city: Targu Mures
country: Romania
facility: Spitalul Clinic Judetean Mures-Gastroenterology ( Site 1607)
state: Mures
city: Timisoara
country: Romania
facility: S.C Centrul de Gastroenterologie Dr. Goldis S.R.L-Gastroenterology ( Site 1601)
state: Timis
city: Bucuresti
country: Romania
facility: S.C. Centrul Medical Medicum SRL-Gastroenterology ( Site 1604)
city: Belgrade
country: Serbia
facility: Clinical Hospital Center Dragisa Misovic ( Site 1708)
state: Beograd
city: Belgrade
country: Serbia
facility: Clinical Hospital Center Zvezdara-Gastroenterology and hepatology Department ( Site 1705)
state: Beograd
city: Belgrade
country: Serbia
facility: University Medical Center "Bezanijska kosa"-Gastroenterology and hepatology ( Site 1704)
state: Beograd
city: Kragujevac
country: Serbia
facility: Clinical Center Kragujevac ( Site 1703)
state: Beograd
city: Zrenjanin
country: Serbia
facility: General Hospital "Djordje Joanovic" ( Site 1707)
state: Srednjebanatski Okrug
city: Brezno
country: Slovakia
facility: Breznianske centrum gastroenterologie ( Site 1806)
state: Banskobystricky Kraj
city: Slovakia
country: Slovakia
facility: Fakultna nemocnica s poliklinikou F.D.Roosevelta Banska Bystrica ( Site 1802)
state: Banskobystricky Kraj
city: Bratislava
country: Slovakia
facility: Cliniq s.r.o. ( Site 1800)
state: Bratislavsky Kraj
city: Kosice
country: Slovakia
facility: ENDOMED ( Site 1801)
state: Kosicky Kraj
city: Nitra
country: Slovakia
facility: KM Management ( Site 1804)
state: Nitriansky Kraj
city: Sahy
country: Slovakia
facility: Accout Center ( Site 1805)
state: Nitriansky Kraj
city: Johannesburg
country: South Africa
facility: Wits Clinical Research-Research ( Site 3208)
state: Gauteng
city: Soweto
country: South Africa
facility: Wits Clinical Research-Wits Clinical Research Bara ( Site 3206)
state: Gauteng
city: Cape Town
country: South Africa
facility: Panorama Medical Centre ( Site 3209)
state: Western Cape
city: Cape Town
country: South Africa
facility: Spoke Research ( Site 3210)
state: Western Cape
city: Cape Town
country: South Africa
facility: Life Kingsbury Hospital ( Site 3203)
state: Western Cape
city: Cape Town
country: South Africa
facility: Private Practice - Dr. M.N. Rajabally ( Site 3213)
state: Western Cape
city: Badalona
country: Spain
facility: Hospital Germans Trias i Pujol ( Site 3413)
state: Barcelona
city: Terrassa
country: Spain
facility: Hospital Universitari Mutua Terrassa ( Site 3416)
state: Barcelona
city: Galdakao-Usansolo
country: Spain
facility: Hospital Galdakao-Usansolo ( Site 3409)
state: Bizkaia
city: Madrid
country: Spain
facility: Hospital La Princesa-Gastroenterology ( Site 3411)
state: Madrid, Comunidad De
city: Madrid
country: Spain
facility: Fundación Jimenez Diaz ( Site 3420)
state: Madrid, Comunidad De
city: Torrejón de Ardoz
country: Spain
facility: Hospital Universitario de Torrejon ( Site 3417)
state: Madrid, Comunidad De
city: Fuenlabrada
country: Spain
facility: Hospital Universitario de Fuenlabrada-Digestive ( Site 3415)
state: Madrid
city: Valencia
country: Spain
facility: HOSPITAL CLINICO DE VALENCIA ( Site 3406)
state: Valenciana, Comunitat
city: València
country: Spain
facility: Hospital Universitari i Politecnic La Fe-Enfermedad Inflamatoria Intestinal ( Site 3405)
state: Valencia
city: Madrid
country: Spain
facility: HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑON-Aparato Digestivo ( Site 3403)
city: Madrid
country: Spain
facility: Hospital Universitario La Paz-Unidad de Enfermedad Inflamatoria Intestinal ( Site 3402)
city: Bern
country: Switzerland
facility: INTESTO-Gastroenterologische Praxis / Crohn-Colitis Zentrum Bern ( Site 1902)
state: Berne
city: St.Gallen
country: Switzerland
facility: Cantonal Hospital St.Gallen-Klinik für Gastroenterologie / Hepatologie ( Site 1901)
state: Sankt Gallen
city: Zürich
country: Switzerland
facility: UniversitätsSpital Zürich-Gastroenterologie & Hepatologie ( Site 1900)
state: Zurich
city: Changhua County
country: Taiwan
facility: Changhua Christian Hospital ( Site 3104)
state: Changhua
city: Zhu Bei City
country: Taiwan
facility: National Taiwan University BioMedical Park Hospital ( Site 3103)
state: Hsinchu
city: Taichung
country: Taiwan
facility: China Medical University Hospital ( Site 3100)
city: Taipei
country: Taiwan
facility: National Taiwan University Hospital ( Site 3102)
city: Taoyuan
country: Taiwan
facility: Chang Gung Medical Foundation-Linkou Branch ( Site 3101)
city: Istanbul- Fatih
country: Turkey
facility: Istanbul Universitesi Cerrahpasa-Internal Diseases ( Site 3503)
state: Istanbul
city: Ankara
country: Turkey
facility: ANKARA UNIVERSITY IBNI SINA HOSPITAL ( Site 3507)
city: Ankara
country: Turkey
facility: Hacettepe Universite Hastaneleri ( Site 3500)
city: Ankara
country: Turkey
facility: Ankara Bilkent Şehir Hastanesi-Gastroenterology ( Site 3501)
city: Antalya
country: Turkey
facility: Antalya Egitim ve Arastirma Hastanesi ( Site 3508)
city: Istanbul
country: Turkey
facility: Marmara Universitesi Pendik Egitim Arastirma Hastanesi ( Site 3505)
city: Ivano-Frankivsk
country: Ukraine
facility: Communal non-profit enterprise "Regional clinical hospital of Ivano-Frankivsk Regional Council" ( Site 4115)
state: Ivano-Frankivska Oblast
city: Kyiv
country: Ukraine
facility: Center of Family Medicine Plus-Treatment Prevention Unit ( Site 4103)
state: Kyivska Oblast
city: Lviv
country: Ukraine
facility: Communal Non-profit Enterprise of Lviv Regional Council "Lviv Regional Clinical Hospital"-proctology ( Site 4109)
state: Lvivska Oblast
city: Vinnytsia
country: Ukraine
facility: Limited liability company "Medical center Health Clinic"-Gastroenterology, Hepatology and Endocrino ( Site 4107)
state: Vinnytska Oblast
city: Vinnytsia
country: Ukraine
facility: Communal Non-Commercial Enterprise "Vinnytsia City Clinical -Clinical Therapeutic Department #1 ( Site 4111)
state: Vinnytska Oblast
city: Vinnytsya
country: Ukraine
facility: Municipal Nonprofit Enterprise "Vinnytsia Regional Clinical -Gastroenterology department ( Site 4114)
state: Vinnytska Oblast
city: Lutsk
country: Ukraine
facility: Municipal Enterprise "Volyn Regional Clinical Hospital" of V-surgery department (abdominal, colopro ( Site 4113)
state: Volynska Oblast
city: Kyiv
country: Ukraine
facility: Medical Center "Universal Clinic "Oberig" of Limited Liability Company "Kapytal" ( Site 4100)
city: Kyiv
country: Ukraine
facility: Dobrobut Medical Center ( Site 4101)
city: Kyiv
country: Ukraine
facility: Medical Center of Private Enterprise "Sygma" ( Site 4108)
city: Bristol
country: United Kingdom
facility: Southmead Hospital ( Site 2004)
state: Bristol, City Of
city: Cambridge
country: United Kingdom
facility: Addenbrooke's Hospital ( Site 2005)
state: Cambridgeshire
city: Exeter
country: United Kingdom
facility: Royal Devon & Exeter Hospital-IBD Research Group ( Site 2001)
state: Devon
city: Doncaster
country: United Kingdom
facility: Doncaster Royal Infirmary ( Site 2006)
state: England
city: Huddersfield
country: United Kingdom
facility: Huddersfield Royal Infirmary ( Site 2010)
state: England
city: London
country: United Kingdom
facility: Whipps Cross University Hospital-Clinical Research Unit ( Site 2000)
state: England
city: London
country: United Kingdom
facility: St. George's Hospital ( Site 2007)
state: England
city: Southampton
country: United Kingdom
facility: Southampton General Hospital-Gastroenterology ( Site 2003)
state: Hampshire
city: London
country: United Kingdom
facility: University College London Hospital-Clinical Research Facility ( Site 2002)
state: London, City Of
city: West Midlands
country: United Kingdom
facility: Walsall Manor Hospital ( Site 2009)
state: Walsall
Study officials:
affiliation: Merck Sharp & Dohme LLC
name: Medical Director
role: STUDY_DIRECTOR
References: