Clinical trial NCT01786928: The Role of Resistance Exercise in Chronic Obstructive Pulmonary Disease Exacerbation
Official title: Impact of Resistance Training During Hospitalization in COPD Patients: a Randomized and Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Chronic Obstructive Pulmonary Disease
Keywords: chronic obstructive pulmonary disease
exacerbation
resistance training
muscle force
Lead sponsor: University of Sao Paulo
Sponsor class: OTHER
Collaborators: name: Fundação de Amparo à Pesquisa do Estado de São Paulo
First posted: 2013-02-08
Enrollment: 34
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine whether resistance exercise are effective in combating the decline in muscle strength during an exacerbation of Chronic Obstructive Pulmonary Disease (COPD).

Detailed description: Acute exacerbations are common in patients with COPD and cause specific signs and symptoms, such as increased dyspnea, productive cough with altered sputum, and fever. With disease progression, exacerbations are frequent and have a negative impact on health related quality of life and pulmonary function as well as increase mortality. More severe exacerbations require hospitalization resulting in enormous health expenditures, severely reducing daily life activities and declining peripheral muscle strength that can be only partially reversed after 3 months. Despite many features have been pointed out as responsible for the decrease in muscle strength during hospitalization, physical inactivity seems the most important.

Resistance training is an interesting therapeutic option to prevent and/or reverse muscular dysfunction due to immobilised in healthy subjects and stable COPD patients because induces hypertrophy of type II fibers, increases muscle strength and exercise tolerance. In addition, provokes lower dyspnea perception during effort compared with other exercise training. Despite these benefits for stable COPD, the impact of a resistance exercise program during hospitalization remains poorly known.

Eligibility criteria: Inclusion Criteria:

* patients hospitalized for exacerbation of COPD

Exclusion Criteria:

* patients presenting change in mental status (confusion, lethargy or coma)
* persistence or worsening in hypoxemia (PaO2\<40mmHg) and/or respiratory acidosis (pH\<7.25) despite oxygen supplementation or use of non-invasive ventilation
* hemodynamic instability requiring vasoactive drugs
* patients transferred to ICU
* hospitalization lower than 5 days
* diseases that prevented the exercises

Primary outcomes:
measure: The benefits of resistance training during exacerbation of COPD on peripheral muscle strength during hospitalization
timeFrame: Will be evaluated on the second day of hospitalization, the day of hospital discharge (this time interval must be longer than five days)
Secondary outcomes:
measure: The benefits of resistance training during exacerbation of COPD on physical activity in daily life
timeFrame: Will be evaluated in the third and fifth day of hospitalization and thirty days after discharge
Other outcomes:
Locations:
city: São Paulo
country: Brazil
facility: University Hospital of sao paulo
Study officials:
affiliation: school of Medicine university of sao paulo
name: Rodrigo C Borges, specialist
role: STUDY_CHAIR
References:
citation: Borges RC, Carvalho CR. Impact of resistance training in chronic obstructive pulmonary disease patients during periods of acute exacerbation. Arch Phys Med Rehabil. 2014 Sep;95(9):1638-45. doi: 10.1016/j.apmr.2014.05.007. Epub 2014 May 28.