Clinical trial NCT03041870: Relationship Between Serotonin and Brain Response to Social Dominance and Emotion Perception.
Official title: Relationship Between Serotonin and Brain Response to Social Dominance Perception and Emotion: a Combined [11C]DASB-PET/fMRI Study in Humans
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Healthy Volunteers
Keywords: PET-fMRI
dominance
5HT transporter
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2017-02-03
Enrollment: 34
Sex: MALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: Previous studies have already revealed the involvement of the serotoninergic system in the social behavior process. For example, more serotonin (5HT) was found in dominant male adult monkeys. Little is known about the serotoninergic implication in human's social behavior. The project aims to clarify the role of the serotoninergic system in social behavior in relation to the process of social hierarchical information. In order to determine how serotoninergic system is involved, the investigator will use a new technic TEP-fMRI. This technic allows us to measure the brain activity and the serotoninergic transporter occupancy (using the \[C11\]-DASB) at the same time. The current study aims to investigate whether serotonin transporter (5-HTT) activity correlates with the neural response (BOLD) during the detection of social dominance in facial expressions or other measures of social information processing. Blood sample, SLC6A4 (allele coding for the 5HT transporter) genotyping and neuropsychological questionnaires will give at the investigator more information and allow to investigate whether performance on social information processing is modulated by personality trait and genotype.


Eligibility criteria: Inclusion Criteria:

* French speaking
* Normal vision
* Age from 18 to 45
* Without psychiatric antecedent
* Without any neurologic antecedent
* Not taking psychotropic or anxiolytic drugs
* Having health insurance coverage

Exclusion Criteria:

* The subject does not wish to be notified of any anomalies detected during MRI
* Subjects suffering from claustrophobia
* Subjects carrying magnetic metal objects that cannot be removed as cochlear implant, surgical clips, piercings, pacemakers, mechanical valves
* Subjects participating in a clinical trial or being in a period of exclusion from a previous clinical trial
* Person under guardianship or curatorship or deprived of liberty or in emergencies
* Taking unauthorized treatment in the month before the completion of the review
* Person whose physical or mental condition does not allow him to pass the test study

Primary outcomes:
measure: level of Blood-Oxygen-Level Dependent (BOLD) signal
timeFrame: at day 0
measure: level of serotonin transporter
timeFrame: at day 0
Secondary outcomes:
measure: Behavioral assessment
timeFrame: at day 0
measure: Testosterone Blood level
timeFrame: after the scan session at day 0
measure: Cortisol Blood level
timeFrame: after the scan session at day 0
measure: SLC6A4 genotyping
timeFrame: at day 0
Other outcomes:
Locations:
city: Bron
country: France
facility: Hospices Civils de Lyon
Study officials:
affiliation: Hospices Civils de Lyon - CNRS UMR 5229
name: Christian SCHEIBER
role: PRINCIPAL_INVESTIGATOR
References: