Clinical trial NCT05118152: Correlation Between 3D Echocardiography and Cardiopulmonary Exercise Testing in Patients With Single Ventricle
Official title: Correlation Between 3D Echocardiography and Cardiopulmonary Exercise Testing in Patients With Single Ventricle: A Cross-sectional Observational Multicenter Prospective Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Single-ventricle
Congenital Heart Disease
Keywords: univentricular heart
Paediatric cardiology
cardiopulmonary exercise test
3D echocardiography
Lead sponsor: University Hospital, Montpellier
Sponsor class: OTHER
Collaborators: name: University Hospital, Bordeaux
First posted: 2021-11-11
Enrollment: 33
Sex: ALL
Minimum age (years): 8
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with a single ventricle or univentricular heart

Brief summary: Congenital heart disease (CHD) is the leading cause of birth defects, with an incidence of 0.8%. Among CHD, univentricular heart disease or "single ventricle" is rare and complex. As a result of the improved patient care over the last decades, the number of children and adults with single ventricle is increasing significantly. Today, the main challenge is to ensure an optimal follow-up of these new patients in order to improve their life expenctancy as well as their quality of life (QoL). Currently, echocardiography and cardiopulmonary exercice test (CPET) are central in management of patients with single ventricle as part of good clinical practice guidelines.

Single ventricle volumes and function are very difficult to asses with conventional echocardiography because of their complex geometry. Indeed, single ventricle size and morphology vary depending on the patient characteristics and on the initial CHD (before surgical repair). That's why conventional 2D echocardiographic parameters are not reliable for single ventricle assessment.

Magnetic resonance imaging (MRI) is more effective in assessing single ventricle volumes and function. Nevertheless, MRI is not universally available, is not practical in many situations, is expensive, and is a relative contraindication in patients with pacemakers.

Over the past decade, the use of the 3D echocardiography has increased. This is an available tool that can assess ventricular function and volumes in few seconds. Recent studies shown a good correlation between 3D echocardiography and MRI for assessment of ventricular volumes and function in patient with CHD and especially in those with single ventricle.

Moreover, according to some authors, CPET parameters are strongly correlated with risk of hospitalization, risk of death, physical activity and quality of life, especially in patients with single ventricle.

To date, there is no study performed about the relationship between 3D echocardiography and CPET parameters in patients with single ventricle.

Detailed description: This is a cross-sectional, observational, multicenter, and prospective study Eligible patients will be included during their usual medical check-up. As recommended by guidelines, patients with single ventricle have an 2D echocardiography and a CPET annualy. Data required for this study will be collected from patient medical record.

3D echography data acquisition will be performed using 2D ultrasound post-processing by TOMTEC software. No supplementary visit, directly related to the research, will be necessary. This study does not change the usual care management of the patient.

Eligibility criteria: Inclusion criteria:

* Patient over 8 years old with univentricular heart disease as defined by the ACC-CHD classification
* Agreement from adults or parents if minor patients
* CPET performed within the 6 months before or after performing echocardiography

Exclusion criteria:

* Cardiomyopathy unrelated to CHD (eg coronary artery disease, toxic cardiomyopathy)
* Significant clinical status change between performing CPET and performing echocardiography, according to the investigator's opinion

Primary outcomes:
measure: Association between single ventricle volumes and function parameters in 3D echocardiography
timeFrame: day 1
Secondary outcomes:
measure: Association between 3D echocardiography and clinical data collected
timeFrame: day 1
measure: Association between 3D echocardiography and quality of life data usually collected
timeFrame: day 1
measure: ssociation between 3D echocardiography and 2D echocardiography data usually collected
timeFrame: day 1
measure: Association between 3D echocardiography and blood test data usually collected.
timeFrame: day 1
measure: Association between 3D echocardiography and MRI data usually collected.
timeFrame: day 1
measure: Assessment of 3D echocardiography interobserver and intraobserver variability
timeFrame: day 1
Other outcomes:
Locations:
city: Montpellier
country: France
facility: Uh Montpellier
Study officials:
affiliation: UH MONTPELLIER
name: Pascal AMEDRO, MD-PhD
role: STUDY_DIRECTOR
affiliation: UH MONTPELLIER
name: Valentin FEMENIA, resident
role: PRINCIPAL_INVESTIGATOR
References:
citation: Femenia V, Pommier V, Huguet H, Iriart X, Picot MC, Bredy C, Lorca L, De La Villeon G, Guillaumont S, Pasquie JL, Matecki S, Roubertie F, Leobon B, Thambo JB, Jalal Z, Thomas J, Mouton JB, Avesani M, Amedro P. Correlation between three-dimensional echocardiography and cardiopulmonary fitness in patients with univentricular heart: A cross-sectional multicentre prospective study. Arch Cardiovasc Dis. 2023 Apr;116(4):202-209. doi: 10.1016/j.acvd.2023.02.002. Epub 2023 Mar 9.