Clinical trial NCT04437511: A Study of Donanemab (LY3002813) in Participants With Early Alzheimer's Disease (TRAILBLAZER-ALZ 2)
Official title: Assessment of Safety, Tolerability, and Efficacy of Donanemab in Early Symptomatic Alzheimer's Disease
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: PHASE3
Conditions: Alzheimer Disease
Keywords: Alzheimer's
Dementia
Cognitive Impairment
Amyloid Plaque
Lead sponsor: Eli Lilly and Company
Sponsor class: INDUSTRY
First posted: 2020-06-18
Enrollment: 1736
Sex: ALL
Minimum age (years): 60
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The reason for this study is to see how safe and effective the study drug donanemab is in participants with early Alzheimer's disease.

Additional participants will be enrolled to an addendum safety cohort. The participants will be administered open-label donanemab.

Detailed description: TRAILBLAZER-ALZ 2 is a Phase 3, double-blind, placebo-controlled study to evaluate the safety and efficacy of N3pG antibody (donanemab) in participants with early symptomatic AD (prodromal AD and mild dementia due to AD) with the presence of brain amyloid and tau pathology.

Following the double-blind 76-week main study period, a double-blind 78-week long-term extension period is added to further evaluate donanemab efficacy and safety over time. Participants from the addendum safety cohort are not eligible for the extension period.

Eligibility criteria: Inclusion Criteria:

* Gradual and progressive change in memory function reported by participants or informants for ≥ 6 months
* MMSE score of 20 to 28 (inclusive) at baseline
* Meet 18F flortaucipir PET scan (central read) criteria - does not apply to safety cohort
* Meet 18F florbetapir PET scan (central read) criteria
* Have a study partner who will provide written informed consent to participate

Exclusion Criteria:

* Contraindication to MRI or PET scans
* Current treatment with immunoglobulin G (IgG) therapy

Primary outcomes:
measure: Change From Baseline on the Integrated Alzheimer's Disease Rating Scale (iADRS) (Overall Population)
timeFrame: Baseline, Week 76
measure: Change From Baseline on the Integrated Alzheimer's Disease Rating Scale (iADRS) (Intermediate (Low-medium) Tau Population)
timeFrame: Baseline, Week 76
Secondary outcomes:
measure: Change From Baseline on the Mini Mental State Examination (MMSE) Score (Overall Population)
timeFrame: Baseline, Week 76
measure: Change From Baseline on the Mini Mental State Examination (MMSE) Score (Intermediate (Low-medium) Tau Population)
timeFrame: Baseline, Week 76
measure: Change From Baseline on the Alzheimer's Disease Assessment Scale - Cognitive Subscale (ADAS-Cog13) (Overall Population)
timeFrame: Baseline, Week 76
measure: Change From Baseline on the Alzheimer's Disease Assessment Scale - Cognitive Subscale (ADAS-Cog13) (Intermediate (Low-medium) Tau Population)
timeFrame: Baseline, Week 76
measure: Change From Baseline on the Clinical Dementia Rating Scale-Sum of Boxes (CDR-SB) (Overall Population)
timeFrame: Baseline, Week 76
measure: Change From Baseline on the Clinical Dementia Rating Scale-Sum of Boxes (CDR-SB) (Intermediate (Low-medium) Tau Population)
timeFrame: Baseline, Week 76
measure: Change From Baseline on the Alzheimer's Disease Cooperative Study - Instrumental Activities of Daily Living (ADCS-iADL) Score (Overall Population)
timeFrame: Baseline, Week 76
measure: Change From Baseline on the Alzheimer's Disease Cooperative Study - Instrumental Activities of Daily Living (ADCS-iADL) Score (Intermediate (Low-medium) Tau Population)
timeFrame: Baseline, Week 76
measure: Change From Baseline in Brain Amyloid Plaque Deposition as Measured by Amyloid Positron Emission Tomography (PET) Scan
timeFrame: Baseline, Week 76
measure: Change From Baseline in Brain Tau Deposition as Measured by Flortaucipir F18 PET Scan
timeFrame: Baseline, Week 76
measure: Change From Baseline in Brain Volume as Measured by Volumetric Magnetic Resonance Imaging (vMRI)
timeFrame: Baseline, Week 76
measure: Pharmacokinetics (PK): Average Serum Concentration at Steady State of Donanemab
timeFrame: Week 16 to week 20
measure: Number or Participants With Anti-Donanemab Antibodies
timeFrame: Baseline through Week 76
Other outcomes:
Locations:
city: Gilbert
country: United States
facility: Gilbert Neurology
state: Arizona
city: Phoenix
country: United States
facility: Xenoscience
state: Arizona
city: Phoenix
country: United States
facility: Banner Alzheimer's Institute
state: Arizona
city: Scottsdale
country: United States
facility: Perseverance Research Center
state: Arizona
city: Sun City
country: United States
facility: Banner Sun Health Research Institute
state: Arizona
city: Tucson
country: United States
facility: Banner Alzheimer's Institute Tucson
state: Arizona
city: Tucson
country: United States
facility: Center for Neurosciences
state: Arizona
city: Fayetteville
country: United States
facility: Health Initiatives Research
state: Arkansas
city: Carlsbad
country: United States
facility: North County Neurology Associates
state: California
city: Encino
country: United States
facility: Wr- Pri, Llc
state: California
city: Fresno
country: United States
facility: Neuro-Pain Medical Center
state: California
city: Fullerton
country: United States
facility: Neurology Center of North Orange County
state: California
city: Irvine
country: United States
facility: Irvine Clinical Research
state: California
city: La Jolla
country: United States
facility: Kaizen Brain Center
state: California
city: Laguna Hills
country: United States
facility: Senior Clinical Trials, Inc.
state: California
city: Los Alamitos
country: United States
facility: Collaborative Neuroscience Research, LLC
state: California
city: Los Angeles
country: United States
facility: USC Keck School of Medicine
state: California
city: Los Angeles
country: United States
facility: Clinical Research Institute
state: California
city: Napa
country: United States
facility: Neurovations
state: California
city: Newport Beach
country: United States
facility: Hoag Memorial Hospital Presbyterian
state: California
city: Palo Alto
country: United States
facility: Stanford Neuroscience Health Center
state: California
city: Pasadena
country: United States
facility: SC3 Research - Pasadena
state: California
city: Poway
country: United States
facility: PCND Neurology
state: California
city: Redlands
country: United States
facility: Anderson Clinical Research
state: California
city: San Diego
country: United States
facility: Artemis Institute for Clinical Research
state: California
city: San Diego
country: United States
facility: Pacific Research Network
state: California
city: San Diego
country: United States
facility: Sharp Neurocognitive Research Center
state: California
city: San Francisco
country: United States
facility: UCSF Memory and Aging Center
state: California
city: Santa Ana
country: United States
facility: Syrentis Clinical Research
state: California
city: Sherman Oaks
country: United States
facility: California Neuroscience Research Medical Group, Inc.
state: California
city: Tustin
country: United States
facility: Tilda Research
state: California
city: Basalt
country: United States
facility: Mountain Neurological Research Center
state: Colorado
city: Boulder
country: United States
facility: Alpine Clinical Research Center
state: Colorado
city: Colorado Springs
country: United States
facility: Colorado Springs Neurological Associates
state: Colorado
city: Denver
country: United States
facility: Colorado Neurological Research Center, PC
state: Colorado
city: New Haven
country: United States
facility: Institute for Neurodegenerative Disorders
state: Connecticut
city: New Haven
country: United States
facility: Yale University, Alzheimer's Disease Research Unit
state: Connecticut
city: Norwalk
country: United States
facility: Research Center for Clinical Studies
state: Connecticut
city: Stamford
country: United States
facility: Ki Health Partners, LLc, dba New England Institute for Clinical Research
state: Connecticut
city: Washington
country: United States
facility: Georgetown University Medical Center
state: District of Columbia
city: Atlantis
country: United States
facility: JEM Research Institute
state: Florida
city: Aventura
country: United States
facility: VIN-Julie Schwartzbard
state: Florida
city: Boca Raton
country: United States
facility: Neurology Offices of South Florida
state: Florida
city: Boca Raton
country: United States
facility: SFM Clinical Research
state: Florida
city: Delray Beach
country: United States
facility: Brain Matters Research
state: Florida
city: Delray Beach
country: United States
facility: Cohen Medical Associates
state: Florida
city: Doral
country: United States
facility: Integrity Clinical Research
state: Florida
city: Fort Myers
country: United States
facility: Neuropsychiatric Research Center of Southwest Florida
state: Florida
city: Greenacres City
country: United States
facility: Finlay Medical Research
state: Florida
city: Hallandale Beach
country: United States
facility: MD Clinical
state: Florida
city: Hialeah
country: United States
facility: AGA Clinical Trials
state: Florida
city: Hialeah
country: United States
facility: Indago Research & Health Center, Inc
state: Florida
city: Hollywood
country: United States
facility: Infinity Clinical Research, LLC
state: Florida
city: Jacksonville
country: United States
facility: Encore Research Group- Jacksonville Center for Clinical Research
state: Florida
city: Lakeland
country: United States
facility: Accel Research Sites - Lakeland Clinical Research Unit
state: Florida
city: Maitland
country: United States
facility: ClinCloud - Maitland
state: Florida
city: Merritt Island
country: United States
facility: Merritt Island Medical Research, LLC
state: Florida
city: Miami Beach
country: United States
facility: Mount Sinai Cancer Center
state: Florida
city: Miami Lakes
country: United States
facility: Goji Group - Research Trials Group
state: Florida
city: Miami
country: United States
facility: Homestead Associates in Research
state: Florida
city: Miami
country: United States
facility: Finlay Medical Research
state: Florida
city: Miami
country: United States
facility: Optimus U Corporation
state: Florida
city: Miami
country: United States
facility: Miami Jewish health
state: Florida
city: Miami
country: United States
facility: Future Care Solution
state: Florida
city: Miami
country: United States
facility: Allied Biomedical Research Institute
state: Florida
city: Miami
country: United States
facility: New Horizon Research Center
state: Florida
city: Miami
country: United States
facility: Florida International Research Center
state: Florida
city: Miami
country: United States
facility: Ezy Medical Research
state: Florida
city: Miami
country: United States
facility: Miami Dade Medical Research Institute, LLC
state: Florida
city: Miami
country: United States
facility: The Neurology Research Group
state: Florida
city: Miami
country: United States
facility: VIN-Victor Faradji
state: Florida
city: Naples
country: United States
facility: Collier Neurologic Specialists
state: Florida
city: New Port Richey
country: United States
facility: Suncoast Clinical Research, Inc.
state: Florida
city: Ocala
country: United States
facility: Renstar Medical Research
state: Florida
city: Ocoee
country: United States
facility: Sensible Healthcare, LLC
state: Florida
city: Orange City
country: United States
facility: Medical Research Group of Central Florida
state: Florida
city: Orlando
country: United States
facility: Synexus Clinical Research US, Inc.
state: Florida
city: Orlando
country: United States
facility: Headlands Research Orlando
state: Florida
city: Palmetto Bay
country: United States
facility: IMIC, Inc.
state: Florida
city: Pensacola
country: United States
facility: Emerald Coast Neurology - Airport Boulevard
state: Florida
city: Pompano Beach
country: United States
facility: Quantum Laboratories Clinical Research
state: Florida
city: Port Orange
country: United States
facility: Progressive Medical Research
state: Florida
city: Saint Petersburg
country: United States
facility: Suncoast Neuroscience Associates, Inc.
state: Florida
city: Sarasota
country: United States
facility: Intercoastal Medical Group
state: Florida
city: Sarasota
country: United States
facility: Roskamp Institute Clinical Trials Division
state: Florida
city: Stuart
country: United States
facility: Alzheimer's Research and Treatment Center
state: Florida
city: Stuart
country: United States
facility: Brain Matters Research
state: Florida
city: Tallahassee
country: United States
facility: Tallahassee Neurological Clinic
state: Florida
city: Tampa
country: United States
facility: Axiom Clinical Research of Florida
state: Florida
city: Tampa
country: United States
facility: Stedman Clinical Trials
state: Florida
city: Tampa
country: United States
facility: USF Health Byrd Alzheimer's Institute
state: Florida
city: The Villages
country: United States
facility: Charter Research - Lady Lake
state: Florida
city: The Villages
country: United States
facility: Synexus Clinical Research US, Inc.
state: Florida
city: Wellington
country: United States
facility: Alzheimer's Research and Treatment Center
state: Florida
city: West Palm Beach
country: United States
facility: Palm Beach Neurology
state: Florida
city: Winter Park
country: United States
facility: Conquest Research
state: Florida
city: Winter Park
country: United States
facility: Charter Research - Winter Park
state: Florida
city: Buford
country: United States
facility: Gwinnett Research Institute
state: Georgia
city: Columbus
country: United States
facility: Columbus Memory Center, LLC
state: Georgia
city: Decatur
country: United States
facility: NeuroStudies
state: Georgia
city: Gainesville
country: United States
facility: Center for Advanced Research & Education
state: Georgia
city: Boise
country: United States
facility: Northwest Clinical Trials
state: Idaho
city: Chicago
country: United States
facility: Great Lakes Clinical Trials - Andersonville
state: Illinois
city: Elk Grove Village
country: United States
facility: AMITA Health - Alexian Brothers Neurosciences Institute Clinical Research
state: Illinois
city: Park Ridge
country: United States
facility: Advocate Medical Group
state: Illinois
city: Springfield
country: United States
facility: Southern Illinois University School of Medicine
state: Illinois
city: Indianapolis
country: United States
facility: Indiana University
state: Indiana
city: Indianapolis
country: United States
facility: Josephson Wallack Munshower Neurology, PC
state: Indiana
city: Ames
country: United States
facility: McFarland Clinic, PC
state: Iowa
city: Waterloo
country: United States
facility: Covenant Medical Center
state: Iowa
city: Fairway
country: United States
facility: The University of Kansas - Clinical Research Center
state: Kansas
city: Overland Park
country: United States
facility: College Park Family Care Center/Multi Specialty Clinical Res
state: Kansas
city: Topeka
country: United States
facility: Cotton O'Neil Clinical Research Center - Central Office
state: Kansas
city: Wichita
country: United States
facility: Ascension Via Christi Research
state: Kansas
city: Scarborough
country: United States
facility: Maine Medical Center-Maine Medical Partners Neurology
state: Maine
city: Boston
country: United States
facility: Brigham and Women's Hospital
state: Massachusetts
city: Boston
country: United States
facility: Boston Clinical Trials
state: Massachusetts
city: Fall River
country: United States
facility: NECCR PrimaCare Research
state: Massachusetts
city: New Bedford
country: United States
facility: BTC Network
state: Massachusetts
city: Newton
country: United States
facility: Boston Center for Memory
state: Massachusetts
city: Plymouth
country: United States
facility: Donald S. Marks M.D., P.C.
state: Massachusetts
city: Quincy
country: United States
facility: Alzheimers Disease Center
state: Massachusetts
city: Waltham
country: United States
facility: MedVadis Research Corporation
state: Massachusetts
city: Watertown
country: United States
facility: Adams Clinical
state: Massachusetts
city: Farmington Hills
country: United States
facility: QUEST Research Institute
state: Michigan
city: Flowood
country: United States
facility: Precise Research Centers
state: Mississippi
city: Bolivar
country: United States
facility: Citizens Memorial Hospital District
state: Missouri
city: Chesterfield
country: United States
facility: Clinical Research Professionals
state: Missouri
city: North Kansas City
country: United States
facility: North Kansas City Hospital
state: Missouri
city: Ozark
country: United States
facility: Sharlin Health and Neurology
state: Missouri
city: Saint Louis
country: United States
facility: Arch Clinical Trials
state: Missouri
city: Las Vegas
country: United States
facility: Las Vegas Medical Research
state: Nevada
city: Springfield
country: United States
facility: The Cognitive and Research Center of New Jersey
state: New Jersey
city: Toms River
country: United States
facility: Advanced Memory Research Institute of New Jersey
state: New Jersey
city: Toms River
country: United States
facility: Bio Behavioral Health
state: New Jersey
city: Albany
country: United States
facility: Albany Medical College
state: New York
city: Albany
country: United States
facility: Neurological Associates Albany
state: New York
city: Amherst
country: United States
facility: Dent Neurologic Institute
state: New York
city: Buffalo
country: United States
facility: University at Buffalo - UBMD Neurology
state: New York
city: East Syracuse
country: United States
facility: Clarity Clinical Research
state: New York
city: New York
country: United States
facility: NYU Langone Health
state: New York
city: Rochester
country: United States
facility: University of Rochester Medical Center
state: New York
city: Staten Island
country: United States
facility: Richmond Behavioral Associates
state: New York
city: Syracuse
country: United States
facility: SUNY Upstate Medical University
state: New York
city: Charlotte
country: United States
facility: CHS-Behavioral Health Research
state: North Carolina
city: Greensboro
country: United States
facility: Guilford Neurologic Associates, Inc
state: North Carolina
city: Matthews
country: United States
facility: AMC Research
state: North Carolina
city: Morehead City
country: United States
facility: Carteret Medical Group
state: North Carolina
city: Winston-Salem
country: United States
facility: Accellacare - Winston-Salem
state: North Carolina
city: Canton
country: United States
facility: NeuroScience Research Center
state: Ohio
city: Centerville
country: United States
facility: Valley Medical Research
state: Ohio
city: Cleveland
country: United States
facility: Rapid Medical Research
state: Ohio
city: Columbus
country: United States
facility: Ohio State University
state: Ohio
city: Dayton
country: United States
facility: University of Cincinnati Physicians Company, LLC
state: Ohio
city: Dayton
country: United States
facility: Neurology Diagnostics, Inc.
state: Ohio
city: Oklahoma City
country: United States
facility: IPS Research Company
state: Oklahoma
city: Oklahoma City
country: United States
facility: Lynn Health Science Institute
state: Oklahoma
city: Tulsa
country: United States
facility: Central States Research
state: Oklahoma
city: Portland
country: United States
facility: Summit Headlands
state: Oregon
city: Portland
country: United States
facility: Center for Cognitive Health
state: Oregon
city: Abington
country: United States
facility: Abington Neurological Associates, Ltd.
state: Pennsylvania
city: Philadelphia
country: United States
facility: Penn Medicine: University of Pennsylvania Health System
state: Pennsylvania
city: Plymouth Meeting
country: United States
facility: Keystone Clinical Studies
state: Pennsylvania
city: East Providence
country: United States
facility: Rhode Island Mood & Memory Research Institute
state: Rhode Island
city: Columbia
country: United States
facility: Prism Health Richland Department of Neurology Research
state: South Carolina
city: Cordova
country: United States
facility: Neurology Clinic, P.C.
state: Tennessee
city: Memphis
country: United States
facility: Clinical Neuroscience Solutions, Inc. dba CNS Healthcare
state: Tennessee
city: Austin
country: United States
facility: Senior Adults Specialty Research
state: Texas
city: Beaumont
country: United States
facility: Gadolin Research
state: Texas
city: Dallas
country: United States
facility: Kerwin Medical Center
state: Texas
city: Dallas
country: United States
facility: Neurology Consultants of Dallas, PA
state: Texas
city: DeSoto
country: United States
facility: InSite Clinical Research
state: Texas
city: Houston
country: United States
facility: Houston Methodist Hospital
state: Texas
city: Houston
country: United States
facility: The University of Texas Health Science Center at Houston
state: Texas
city: Round Rock
country: United States
facility: Central Texas Neurology Consultants
state: Texas
city: San Antonio
country: United States
facility: Glenn Biggs Institute for Alzheimers & Neurodegenerative Diseases
state: Texas
city: Bennington
country: United States
facility: The Memory Clinic
state: Vermont
city: Arlington
country: United States
facility: Integrated Neurology Services - Falls Church
state: Virginia
city: Norfolk
country: United States
facility: Sentara Norfolk General Hospital
state: Virginia
city: Richmond
country: United States
facility: National Clinical Research, Inc
state: Virginia
city: Bellevue
country: United States
facility: Northwest Clinical Research Center
state: Washington
city: Kirkland
country: United States
facility: EvergreenHealth Medical Center
state: Washington
city: Seattle
country: United States
facility: University of Washington - Harborview Medical Center
state: Washington
city: Spokane
country: United States
facility: Kingfisher Cooperative
state: Washington
city: Tacoma
country: United States
facility: Universal Research Group
state: Washington
city: Erina
country: Australia
facility: Central Coast Neurosciences Research
state: New South Wales
city: Sydney
country: Australia
facility: St Vincent's Hospital
state: New South Wales
city: Sydney
country: Australia
facility: HammondCare Greenwich Hospital
state: New South Wales
city: Sydney
country: Australia
facility: KARA Institute for Neurological Diseases
state: New South Wales
city: Carlton
country: Australia
facility: NeuroCentrix
state: Victoria
city: Glen Iris
country: Australia
facility: Delmont Private Hospital
state: Victoria
city: Malvern
country: Australia
facility: HammondCare
state: Victoria
city: Melbourne
country: Australia
facility: The Alfred Hospital
state: Victoria
city: Parkville
country: Australia
facility: The Royal Melbourne Hospital
state: Victoria
city: Kelowna
country: Canada
facility: OCT Research ULC
state: British Columbia
city: Halifax
country: Canada
facility: True North Clinical Research
state: Nova Scotia
city: New Minas
country: Canada
facility: True North Clinical Research
state: Nova Scotia
city: Newmarket
country: Canada
facility: SKDS Research Inc.
state: Ontario
city: Ottawa
country: Canada
facility: Ottawa Memory Clinic
state: Ontario
city: Ottawa
country: Canada
facility: Bruyère Research Institute
state: Ontario
city: Peterborough
country: Canada
facility: Kawartha Centre - Redefining Healthy Aging
state: Ontario
city: Sarnia
country: Canada
facility: Bluewater Clinical Research Group Inc.
state: Ontario
city: Toronto
country: Canada
facility: Toronto Memory Program
state: Ontario
city: Toronto
country: Canada
facility: Sunnybrook Health Sciences Centre
state: Ontario
city: Toronto
country: Canada
facility: Baycrest Health Sciences
state: Ontario
city: Gatineau
country: Canada
facility: Clinique de la Mémoire de l'Outaouais
state: Quebec
city: Greenfield Park
country: Canada
facility: MoCA Research and Innovation Inc.
state: Quebec
city: Sherbrooke
country: Canada
facility: Q&T Research Sherbrooke Inc.
state: Quebec
city: Sherbrooke
country: Canada
facility: Diex Recherche Sherbrooke Inc.
state: Quebec
city: Quebec
country: Canada
facility: Alpha Recherche Clinique
city: Quebec
country: Canada
facility: ALPHA Recherche Clinique
city: Pilsen
country: Czechia
facility: A-Shine
state: Plzeň-město
city: Praha
country: Czechia
facility: Clintrial s.r.o.
state: Praha 10
city: Prague
country: Czechia
facility: Neuropsychiatrie
state: Praha 6
city: Praha
country: Czechia
facility: Neurologická Ambulance - Forbeli
state: Praha 6
city: Hostivice
country: Czechia
facility: Clinline Services
state: Středočeský Kraj
city: Kladno
country: Czechia
facility: Brain-Soul Therapy
state: Středočeský Kraj
city: Nagoya-shi
country: Japan
facility: Nagoya Ekisaikai Hospital
state: Aichi
city: Nagoya
country: Japan
facility: Chubu Rosai Hospital
state: Aichi
city: Nagoya
country: Japan
facility: Kojunkai Daido Clinic
state: Aichi
city: Obu
country: Japan
facility: National Center for Geriatrics and Gerontology
state: Aichi
city: Inage
country: Japan
facility: Inage Neurology and Memory Clinic
state: Chiba
city: Akashi
country: Japan
facility: Matsui e-clinic
state: Hyogo
city: Himeji
country: Japan
facility: Himeji Central Hospital Affiliated Clinic
state: Hyogo
city: Kobe
country: Japan
facility: Kobe University Hospital
state: Hyogo
city: Kobe
country: Japan
facility: Kobe City Medical Center General Hospital
state: Hyogo
city: Kobe
country: Japan
facility: Kakigi Dementia Happiness Clinic
state: Hyogo
city: Inashiki
country: Japan
facility: Tokyo Medical University Ibaraki Medical Center
state: Ibaraki
city: Toride
country: Japan
facility: Memory Clinic Toride
state: Ibaraki
city: Yokohama
country: Japan
facility: Yokohama City Minato Red Cross Hospital
state: Kanagawa
city: Yufu
country: Japan
facility: Oita University Hospital
state: Oita
city: Kurashiki
country: Japan
facility: Katayama Medical Clinic
state: Okayama
city: Ikeda
country: Japan
facility: Honmachi Clinic
state: Osaka
city: Takatsuki
country: Japan
facility: Takatsuki General Hospital
state: Osaka
city: Chuo-ku
country: Japan
facility: Medical Corporation Chiseikai Tokyo Center Clinic
state: Tokyo
city: Edogawa-ku
country: Japan
facility: Moriyama Neuro Center Hospital
state: Tokyo
city: Hachioji
country: Japan
facility: P-One Clinic
state: Tokyo
city: Shinjuku-ku
country: Japan
facility: Clinical Research Hospital Tokyo
state: Tokyo
city: Sumida-ku
country: Japan
facility: Tokyo Metro Bokutoh Hospital
state: Tokyo
city: Hiroshima
country: Japan
facility: Hiroshima Neurology Clinic
city: Kyoto
country: Japan
facility: Koseikai Takeda Hospital
city: Kyoto
country: Japan
facility: Ishikawa Clinic
city: Kyoto
country: Japan
facility: National hospital Organization Utano National Hospital
city: Oita
country: Japan
facility: Oita Prefectural Hospital
city: Tokushima
country: Japan
facility: Itsuki Hospital
city: Tokyo
country: Japan
facility: Tokyo Asbo Clinic
city: Tokyo
country: Japan
facility: Nippon Medical School Hospital
city: Tokyo
country: Japan
facility: Makita General Hospital
city: Leeuwarden
country: Netherlands
facility: QPS Netherlands B.V
state: Fryslân
city: 's-Hertogenbosch
country: Netherlands
facility: Brain Research Center Den Bosch B.V.
state: Noord-Brabant
city: Amsterdam
country: Netherlands
facility: Brain Research Center
state: Noord-Holland
city: Zwolle
country: Netherlands
facility: Brain Research Center Zwolle
state: Overijssel
city: Scinawa
country: Poland
facility: Ośrodek Badawczo Naukowo Dydaktyczny Chorób Otępiennych Im Księdza Henryka Kardynała Gulbinowicza Uniwersy -T
state: Dolnośląskie
city: Wroclaw
country: Poland
facility: Wroclawskie Centrum Alzheimerowskie
state: Dolnośląskie
city: Bydgoszcz
country: Poland
facility: Centrum Medyczne NEUROMED
state: Kujawsko-pomorskie
city: Lublin
country: Poland
facility: Private Practice - Dr. Urszula Chyrchel- Paszkiewicz
state: Lubelskie
city: Warsawawa
country: Poland
facility: Centrum Medyczne NeuroProtect
state: Mazowieckie
city: Warszawa
country: Poland
facility: FutureMeds Warszawa Centrum
state: Mazowieckie
city: Krakow
country: Poland
facility: Diamond Clinic
state: Małopolskie
city: Białystok
country: Poland
facility: KLIMED Marek Klimkiewicz
state: Podlaskie
city: Białystok
country: Poland
facility: Podlaskie Centrum Psychogeriatrii
state: Podlaskie
city: Gdansk
country: Poland
facility: Centrum Badan Klinicznych PI-House sp. z o.o.
state: Pomorskie
city: Sopot
country: Poland
facility: Centrum Medyczne SENIOR
state: Pomorskie
city: Poznan
country: Poland
facility: Nzoz Neuro-Kard Ilkowski i Partnerzy SPL
state: Wielkopolskie
city: Szczecin
country: Poland
facility: Centrum Medyczne Euromedis
state: Zachodniopomorskie
city: Katowice
country: Poland
facility: Klinika Neuro-Care
state: Śląskie
city: Bayamon
country: Puerto Rico
facility: SCB Research Center
city: San Juan
country: Puerto Rico
facility: INSPIRA Clinical Research
city: San Juan
country: Puerto Rico
facility: Instituto De Neurologia Dra. Ivonne Fraga
city: San Juan
country: Puerto Rico
facility: Barbara Diaz-Hernandez MD Research, Inc.
city: Motherwell
country: United Kingdom
facility: Glasgow Memory Clinic
state: Great Britain
city: London
country: United Kingdom
facility: Re:Cognition Health - London
state: London, City Of
city: Guildford
country: United Kingdom
facility: Re:Cognition Health Guildford
state: Surrey
city: Birmingham
country: United Kingdom
facility: Re:Cognition Health - Birmingham
Study officials:
affiliation: Eli Lilly and Company
name: Call 1-877-CTLILLY (1-877-285-4559) or 1-317-615-4559 Mon - Fri 9 AM - 5 PM Eastern time (UTC/GMT - 5 hours, EST)
role: STUDY_DIRECTOR
References: