Clinical trial NCT06537388: High Frequency Jet Ventilation Versus Conventional Positive Pressure Ventilation for EBUS
Official title: Comparison of High Frequency Jet Ventilation and Conventional Positive Pressure Ventilation for Endobronchial Ultrasound Examinations
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Intermittent Positive-Pressure Ventilation
High-Frequency Jet Ventilation
Ultrasonography, Interventional
Lead sponsor: Erasme University Hospital
Sponsor class: OTHER
First posted: 2024-08-05
Enrollment: 428
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients who underwent EBUS for any indication at Erasme University Hospital using either HFJV or IPPV between january 1st 2019 and december 31st 2019 or january 1st 2023 and december 31st 2023.

Brief summary: Endobronchial ultrasound (EBUS) is frequently used in pneumology for diagnostic procedures like mediastinal biopsies. This procedure is usually done under general anesthesia. Different methods of ventilation are used according to center and physician preferences. In this retrospective study, complications of 2 types of ventilation will be analyzed:

* High frequency jet ventilation (HFJV)
* Conventional intermittent positive pressure ventilation (IPPV) Descriptive statistics will be used to present the data. Both ventilation techniques will be compared after propensity score matching. For HFJV patients from 2019 will be analyzed and for IPPV patients from 2023, as the team changed its practice over time.


Eligibility criteria: Inclusion Criteria:

* All patients who underwent EBUS at Erasme University Hospital using either HFJV or IPPV between january 1st 2019 and december 31st 2019 or january 1st 2023 and december 31st 2023.

Exclusion Criteria:

* Incomplete medical chart
* Patients who expressed an opposition to the use of their medical data
* Age \< 18 years

Primary outcomes:
measure: Hypoxia
timeFrame: 24 hours
measure: Severe hypoxia
timeFrame: 24 hours
measure: Hemodynamic instability
timeFrame: 24 hours
measure: Cardiac arrythmia
timeFrame: 24 hours
measure: Laryngospasm
timeFrame: 24 hours
measure: ICU admission
timeFrame: 24 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Brussels
country: Belgium
facility: Hôpital Universitaire de Bruxelles - Hôpital erasme
Study officials:
References:
citation: Prasad KT, Sehgal IS, Gupta N, Singh N, Agarwal R, Dhooria S. Endoscopic ultrasound (with an echobronchoscope)-guided fine-needle aspiration for diagnosis of a mediastinal lesion in a mechanically ventilated patient: A case report and systematic review of the literature. Indian J Crit Care Med. 2016 Oct;20(10):608-612. doi: 10.4103/0972-5229.192057.
citation: Anwar M, Fritze R, Base E, Wasserscheid T, Wolfram N, Koinig H, Hackner K, Lambers C, Schweiger T, Errhalt P, Hoda MA. Infraglottic versus supraglottic jet-ventilation for endobronchial ultrasound-guided transbronchial needle aspiration: A randomised controlled trial. Eur J Anaesthesiol. 2020 Nov;37(11):999-1007. doi: 10.1097/EJA.0000000000001220.
citation: Poling HE, Wolfson B, Siker ES. A technique of ventilation during laryngoscopy and bronchoscopy. Br J Anaesth. 1975 Mar;47(3):382-4. doi: 10.1093/bja/47.3.382.
citation: Klain M, Smith RB. High frequency percutaneous transtracheal jet ventilation. Crit Care Med. 1977 Nov-Dec;5(6):280-7. doi: 10.1097/00003246-197711000-00007. No abstract available.
citation: Hautmann H, Gamarra F, Henke M, Diehm S, Huber RM. High frequency jet ventilation in interventional fiberoptic bronchoscopy. Anesth Analg. 2000 Jun;90(6):1436-40. doi: 10.1097/00000539-200006000-00034.