louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04995861: A Comparison Between The Analgesic Efficacy of Adductor Canal Block Alone and Adductor Canal With IPACK (Interspace Between Popliteal Artery and Capsule of the Knee) Block for Knee Surgeries
Official title: A Comparison Between The Analgesic Efficacy of Adductor Canal Block Alone and Adductor Canal With IPACK (Interspace Between Popliteal Artery and Capsule of the Knee) Block for Knee Surgeries
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Nerve Blocks
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2021-08-09
Enrollment: 50
Sex: ALL
Minimum age (years): 21
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: A comparison between The analgesic efficacy of adductor canal block alone and adductor canal with IPACK (interspace between popliteal artery and capsule of the knee) block for knee surgeries


Eligibility criteria: Inclusion Criteria:

* patients undergoing knee surgery i.e. arthroscopy, total knee replacement, ACL repair.
* ASA physical status I to III
* Sex (males and females)
* Age 21-70 years.

Exclusion Criteria:

* Hypersensitivity to local anesthetics. Preexisting peripheral neuropathy. Infection near site of infections e.g. osteomyelitis, septic knee joint. Etc. Patient refusal. PAny contraindications for spinal anesthesia. ( eg: coagulopathy, use of anticoagulants

Primary outcomes:
measure: Assessment of post operative pain
timeFrame: One year
Secondary outcomes:
measure: Range of movement and ambulation
timeFrame: One year
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Ain Shams University
Study officials:
References:
Clinical trial NCT00477061: Morphine Analgesia in Patients With Acute Appendicitis
Official title: Double Blind Randomized Study of Morphine Analgesia in Patients With Acute Appendicitis
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Appendicitis
Keywords: MORPHINE
ANALGESIA
ACUTE APPENDICITS
Lead sponsor: Tehran University of Medical Sciences
Sponsor class: OTHER
First posted: 2007-05-22
Enrollment: 71
Sex: ALL
Minimum age (years): 13
Maximum age (years): 75
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The purpose of the study is to evaluate morphine effect on pain reduction and diagnostic accuracy in patients admitted to emergency ward with the diagnosis of acute appendicitis.

Detailed description: Analgesic administration for pain control in patients with acute abdominal pain, regarding acute appendicitis, is controversial. Despite the results previous studies indicating the safeness of analgesic use in ED for acute abdominal pain, physicians still prefer to postpone their use after performing surgical evaluations. Since many patients admitted to ED are unlikely to receive prompt surgical consultation, many of them need pain relief to prevent unnecessary suffering. On the other hand such pain relief must not interfere with the diagnosis and treatment of patients and do not cause any complications. Morphine is a common and effective analgesic which, if shown to have no effect on correct diagnosis of acute abdomen, can be used for this purpose.

Thus we evaluated morphine effect on pain reduction and diagnostic accuracy in patients admitted to ED with the diagnosis of acute appendicitis.

Eligibility criteria: Inclusion Criteria:

* clinical signs of acute appendicitis
* planned for appendectomy
* supposed to wait for at least 1 hour in the ED before operation

Exclusion Criteria:

* suspicion to perforated appendicitis
* being under the age of 13
* pregnancy (according to history and ß-HCG result)
* opium addiction
* systolic blood pressure of less than 90 mmHG
* known cases of chronic obstructive pulmonary disease (COPD)
* known sensitivity to morphine
* history of sickle cell disease
* self administration of analgesics before enrollment
* refusal to participate

Primary outcomes:
measure: Pain Intensity
Secondary outcomes:
measure: Diagnostic Accuracy
Other outcomes:
Locations:
city: Tehran
country: Iran, Islamic Republic of
facility: Sina General Hospital
Study officials:
affiliation: Tehran University of Medical Sciences
name: Asieh Golozar, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Amoli HA, Golozar A, Keshavarzi S, Tavakoli H, Yaghoobi A. Morphine analgesia in patients with acute appendicitis: a randomised double-blind clinical trial. Emerg Med J. 2008 Sep;25(9):586-9. doi: 10.1136/emj.2007.050914.
Clinical trial NCT01188161: Postural Effects of Being Rotated in a Whole Body Gyroscope
Official title: The Effects of Whole Body Rotations in the Pitch and Yaw Planes on Postural Stability
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Falls
Balance
Movement Disorders
Keywords: Posturography
Balance
Falls
Gyroscope
Rotational Chair
Vestibular
Movement Disorders
Lead sponsor: Carrick Institute for Graduate Studies
Sponsor class: OTHER
First posted: 2010-08-25
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Normal healthy volunteers without a history of vertigo or dizziness

Brief summary: Subjects will be secured and rotated in a whole body gyroscope, similar to a flight trainer for astronauts. The rotations will be in many directions and the speed will be at 90 deg/sec. The effects of this rotation on the ability to stand upright will be measured.

Detailed description: Computerized dynamic posturography (CDP) testing will be obtained after practice sessions on all subjects using a CAPS Pro system (Vestibular Technologies, Cheyenne WY, USA). All tests will be conducted with the subject standing on a perturbing foam cushion. Six different conditions will be tested in sequence without the subjects stepping away from the foam/platform in order to assess if the center of sway position changed with the changing test conditions: (1) Eyes Open Head Neutral, (2) Eyes Closed Head Neutral, (3) Eyes Closed Head Right, (4) Eyes Closed Head Left, (5) Eyes Closed Head Flexed, (6) Eyes Closed Head Extended. Subjects will be continuously rotated in a computer-controlled multi-axis chair (Gyrostim by UltraThera Technologies, Inc.) in combinations of whole body Pitch and Yaw simultaneously over a 40 second profile at 90 deg/sec (15 RPM). The acceleration rates to 90 degrees per second as well as deceleration rates will be linear and occur in 1 second. We will utilize rotations that will represent all combinations of pitch and yaw with Pitch direction changing two times and Yaw direction four times (Backward Pitch -20 seconds with right Yaw-10 seconds to left Yaw-10 seconds, to Forward Pitch- 20 seconds with right Yaw-10 seconds to left Yaw 10 seconds). Post rotational CDP testing will be compared to the Pre Rotational CDP,

Eligibility criteria: Inclusion Criteria:

* Normal Healthy Adults without a history of vertigo or dizziness

Exclusion Criteria:

* History of dizziness or vertigo

Primary outcomes:
measure: Computerized Dynamic Posturography
timeFrame: 10 minutes after Rotation
Secondary outcomes:
Other outcomes:
Locations:
city: Marietta
country: United States
facility: Life University
state: Georgia
Study officials:
affiliation: Life University
name: Stephanie Sullivan, DC
role: STUDY_CHAIR
References:
Clinical trial NCT01316861: Efficacy and Safety of Oral Acarbose Treatment in Patients With Type 2 Diabetes Mellitus
Official title: A Prospective, Randomized, Multicenter Study of the Efficacy and Safety of Oral Acarbose Treatment in Patients With Type 2 Diabetes Mellitus
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Type 2 Diabetes Mellitus
Lead sponsor: EMS
Sponsor class: INDUSTRY
First posted: 2011-03-16
Enrollment: 79
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The Purpose of This Study is to Evaluate the Efficacy and Safety of Acarbose in Type 2 Diabetic Patients Using Two Different Formulations of Acarbose 50mg.

Detailed description: Study Design:

* Multicenter
* Phase III
* Randomized
* Double Blind
* Prospective and Comparative
* Experiment duration: 105 days
* 5 visits
* Efficacy
* Adverse event

Eligibility criteria: Inclusion Criteria:

* Patients must be able to understand the study procedures agree to participate and give written consent.
* Diagnosed with type 2 diabetes mellitus (t2dm)b
* Female patients of childbearing potential (i.e., ovulating, pre-menopausal, not surgically sterile) which agree to use a medically accepted contraceptive regimen for the duration of the study.

Exclusion Criteria:

* Pregnancy or risk of pregnancy.
* Lactation
* Any pathology or past medical condition that can interfere with this protocol
* Other conditions deemed reasonable by the medical investigator as to the disqualification of the individual from study participation.
* Known hypersensitivity / intolerance to acarbose or any of its excipients

Primary outcomes:
measure: Glycosylated hemoglobin (HbA1c)
timeFrame: Change from baseline to day 98
Secondary outcomes:
measure: Decrease in mean Fasting Plasma Glucose (FPG)
timeFrame: Change from baseline to day 14, 28, 42, 70 and 98
measure: Safety will be evaluated by the Adverse events occurence
timeFrame: Day 105
Other outcomes:
Locations:
city: Sao Jose Dos Campos
country: Brazil
facility: Marcio Antonio Pereira Clinica
state: SP
Study officials:
affiliation: EMS S/A
name: Felipe Pinho, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT04911283: Brucella Serology and History of Brucellosis in Patients With Modic Changes Type 1
Official title: Mehmet Akif İnan Education and Research Hospital
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Brucellosis
Spinal Degeneration
Lead sponsor: Sanliurfa Mehmet Akif Inan Education and Research Hospital
Sponsor class: OTHER
First posted: 2021-06-03
Enrollment: 118
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with MCs and age/sex-matched healthy controls

Brief summary: Objective: This study aims to examine Brucella serology and history of brucellosis in patients with lumbar Modic changes (MCs) type 1, considering results from cross-sectional and case-control comparisons.

Design: In comparative cross-sectional design, MCs type 1 patients (study group) and MCs type 2 patients (comparator group) were examined in terms of Brucella serology by using agglutination with Coombs test. In addition, in comparative case-control design, both of the MCs groups and age/sex-matched healthy controls were investigated for their medical history regarding brucellosis.


Eligibility criteria: Inclusion Criteria:

* Patients with lumbar Modic changes type 1
* Patients with lumbar Modic changes type 2
* Participant who given informed consent for the study

Exclusion Criteria:

* Patients aged\<18 years
* History of serious lumbar trauma
* Lumbar spinal surgery
* Scoliosis
* Cooperation disorder

Primary outcomes:
measure: Serology for brucellosis
timeFrame: 30 minutes
measure: History of brucellosis
timeFrame: 7 minutes
Secondary outcomes:
Other outcomes:
Locations:
city: Şanlıurfa
country: Turkey
facility: Mehmet Akif İnan Hospital
Study officials:
affiliation: Mehmet Akif İnan Hospital
name: Veysel Delen
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01770483: The Role Of Nitazoxanide, Interferon Alfa And Ribavirin In Treatment Of Hepatitis C Infected Type 2 Diabetic Patients
Official title: The Role Of Nitazoxanide, Interferon Alfa And Ribavirin In Treatment Of Hepatitis C Infected Type 2 Diabetic Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Hepatitis C, Chronic
DIABETES MELLITUS Type 2
Keywords: Nitazoxanide,
Sustained viral response
Type 2 DIABETICS
Lead sponsor: Services Institute of Medical Sciences, Pakistan
Sponsor class: OTHER_GOV
Collaborators: name: Getz Pharma
First posted: 2013-01-17
Enrollment: 66
Sex: ALL
Minimum age (years): 35
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to investigate if nitazoxanide used in combination with interferon alfa and ribavirin is effective in treating Hepatitis c infected type 2 Diabetic patients by improving their sustained viral response by more than 80%.Considering that the study is being conducted in a third world country like Pakistan, the standard treatment of hepatitis C is not cost effective. The aim is to introduce a new treatment comparable in efficacy to peginterferon and also cost effective.

Detailed description: After taking proper informed consent from patients, patients who fulfill the research criteria are randomized into 2 groups (control/study). Patients in both groups will be treated with conventional interferon alfa and Ribavirin.Those in study group will be given tab nitazoxanide 500mg twice daily in addition to conventional treatment. The patients will be followed up at regular intervals: 0,4,12,24,48 week.At each visit Hepatitis C Virus(PCR)RNA, Liver function tests, complete blood count will be done.

Eligibility criteria: Inclusion Criteria:

* Hepatitis C genotype 3a
* Hepatitis C Virus(PCR)RNA Detected
* Alanine transaminase \>60
* Diabetic HbA1c\<8
* BMI\>23

Exclusion Criteria:

* Previously treated Hepatitis C patients
* Pregnant females
* Decompensated liver disease,Child class B OR above
* Thyroid disease,Thyroid stimulating hormone\>10,0.05
* Absolute neutrophil count\<1500,Platelets\<80,000,Hb\<10g Female,\<11g Male
* Severe cardiac disease,New York Heart Association2
* Moderate to severe depression assessed by Beck Depression Inventory scale

Primary outcomes:
measure: Sustained Viral Response,
timeFrame: 48 WEEK
Secondary outcomes:
measure: Normalization of Alanine Transferase Test
timeFrame: 48week
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Endocrinology and Diabetes management centre
state: Punjab
Study officials:
affiliation: Principal SIMS/Services hospital lahore
name: FAISAL MASUD, FRCP
role: STUDY_DIRECTOR
affiliation: Senior registrar ,Services hospital lahore/SIMS
name: AMENA MIRZA, MRCP,FCPS
role: PRINCIPAL_INVESTIGATOR
affiliation: House Officer Services Hospital Lahore
name: Madiha Fida, MBBS
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06654583: Effectiveness of Developed Interactive Play Mat In Pediatric Physical Therapy
Official title: Effectiveness of Developed Interactive Play Mat In Pediatric Physical Therapy
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Pediatric ALL
Lead sponsor: Superior University
Sponsor class: OTHER
First posted: 2024-10-23
Enrollment: 54
Sex: ALL
Minimum age (years): 2
Maximum age (years): 5
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The proposed study seeks to innovate by harnessing the potential of an interactive play mat, integrating haptic feedback and captivating sensory stimuli, to facilitate and expedite the motor skill development process in children with delayed milestones.

Detailed description: This research endeavors to contribute substantively to the field of pediatric therapy by providing an engaging, effective, and accessible intervention that aligns with the specific needs of this vulnerable population.

Eligibility criteria: Inclusion Criteria:

* Delayed Milestones, 2-5 Years of age

Exclusion Criteria:

* Spina Bifida, Hydrocephalus

Primary outcomes:
measure: Gross motor function classification system
timeFrame: 12 Months
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Chaudary Muhammad Akram Teaching Hospital, Azra Naheed Medical College, Superior University
state: Punjab
Study officials:
References:
Clinical trial NCT04042883: Acute Normovolemic Hemodilution in Off-pump CABG
Official title: Acute Normovolemic Hemodilution Using Hydroxyethyl Starch (HES 130/0.4) in Patients Undergoing Off-pump Coronary Artery Bypass Grafting Surgery: Effects on Central and Peripheral Perfusion
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Acute Normovolemic Hemodilution
Off-Pump Coronary Artery Bypass Surgery
Keywords: Perfusion
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2019-08-02
Enrollment: 50
Sex: ALL
Minimum age (years): 40
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: To study the effects of Acute normovolemic hemodilution on central and peripheral perfusion in patients Undergoing off-pump coronary artery bypass grafting surgery

Detailed description: Off-pump coronary artery bypass surgery is an alternative to conventional coronary artery bypass grafting using cardiopulmonary bypass (CPB). It avoids adverse effects of CPB such as systemic inflammatory response, impaired myocardial protection, and air or plaque embolism. However, OPCAB surgery involves displacement and manipulation of the heart to expose target coronary arteries. These manipulations cause hemodynamic instability as a result of transient annulo-mitral distortion and acute mitral regurgitation, compression of the right ventricle, and impaired cardiac contractility due to epicardial stabilizers. signs of impaired perfusion such as metabolic acidosis, increased serum lactate and decreased urine output are commonly seen intraoperatively

Excessive surgical bleeding causes hypovolemia and hemodynamic instability, anemia, and reduced oxygen delivery to tissues

Acute normovolemic hemodilution (ANH) is an alternative method of management of intraoperative blood loss, in which a certain volume of blood is collected from the patient, stored at room temperature and replaced by an equal volume of colloid solution. By the end of surgery, this blood is returned to the patient, usually within eight hours of collection, with little deterioration of platelets or coagulation factors

This work aims to study the effects of Acute normovolemic hemodilution on central and peripheral perfusion in patients Undergoing off-pump coronary artery bypass grafting surgery

Eligibility criteria: Inclusion Criteria:

* Patients scheduled for off- pump CABG surgery

Exclusion Criteria:

* Ejection fraction less than 40%
* Hematocrit less than 11 g/dl
* patients with severe renal impairment

Primary outcomes:
measure: Central venous oxygen saturation
timeFrame: Intraoperative
measure: The perfusion index
timeFrame: Intraoperative
measure: Serum lactate
timeFrame: Intraoperative
Secondary outcomes:
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Assiut University
Study officials:
References:
Clinical trial NCT03206983: Efficacy of the Canabrava/s Pupil Expansion Device in Cataract Surgery With Small Pupils: The First 30 Cases
Official title: Efficacy of the Canabrava/s Pupil Expansion Device in Cataract Surgery With Small Pupils: The First 30 Cases
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Small Pupil
Cataract
Keywords: Small pupil
Lead sponsor: Santa Casa de Misericórdia de Belo Horizonte
Sponsor class: OTHER
First posted: 2017-07-02
Enrollment: 29
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: To evaluate the intraoperative stability, safety and overall efficacy of the Canabrava Ring (AJL - SPAIN) when used to expand pupils with less diameter than 5 mm and pupils with sphincter synechiae.

Detailed description: In this consecutive case series, 30 eyes of 29 patients underwent cataract surgery using a new disposable small-pupil expansion device, Canabrava's Ring (AJL Ophthalmic, Spain). It is the first iris expansion ring produced with indents that do not align with each other in the superior and inferior regions, resulting in a small vertical length (0.4mm) that minimizes risk of endothelial contact. All eyes had poorly preoperatively dilated pupils of less than 5mm. Fifteen eyes had significant infective or traumatic pathology preoperatively. Vertical and horizontal pupil diameters were evaluated pre-, intra- and 1 month postoperatively, and were used to calculate pupil circumference. Intraoperative and postoperative pupil circumference comprised the primary outcomes of interest.

Eligibility criteria: Inclusion Criteria:

* clinical indication for cataract surgery, age of at least 18 years, pupil diameter less than 5mm after dilation with phenylephrine and tropicamide, and lens with any degree of opacity.

Exclusion Criteria:

* eyes unable to perceive light during visual acuity testing, pupils with a diameter greater than 5mm and clear lenses

Primary outcomes:
measure: Incidence of adverse events
timeFrame: 30 days after surgery
Secondary outcomes:
measure: Stability of the device during surgery
timeFrame: During surgery
Other outcomes:
Locations:
Study officials:
affiliation: Santa Casa de Misericórdia de Belo Horizonte
name: Sergio Canabrava, MD
role: STUDY_CHAIR
References: