louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02619409: Evaluation of the Duration of Bupivacaine Spinal Block in Orthopedic Procedures With and Without Epinephrine Wash
Official title: Evaluation of the Duration of Bupivacaine Spinal Block as the Primary Anesthetic for Orthopedic Procedures With and Without Epinephrine Wash
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Arthropathy of Hip
Arthropathy of Knee
Lead sponsor: Medical University of South Carolina
Sponsor class: OTHER
First posted: 2015-12-02
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Bupivacaine spinal is commonly performed as the primary anesthetic for orthopedic procedures. In some cases the duration of the block is inadequate. An epinephrine wash is sometimes performed to prolong the duration of the block. The epinephrine wash may prolong the duration of the block, and if it does, to what extent?


Eligibility criteria: Inclusion Criteria:

* 18 years of age or older
* Patients scheduled for total hip or knee replacement

Exclusion Criteria:

* Patients taking anticoagulation
* Infection at or near the intended needle insertion site
* Patients with sacral decubitus ulcer at or near the intended needle insertion site aortic stenosis
* Complex spine anatomy
* ASA class greater than III
* Failed SAB as determined by the staff anesthesiologist

Primary outcomes:
measure: Duration of Sensory Block
timeFrame: 12 hours
measure: Duration of Motor Block
timeFrame: 12 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Charleston
country: United States
facility: Medical University of South Carolina
state: South Carolina
Study officials:
affiliation: Medical University of South Carolina
name: Eric Bolin, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06990009: The Effect of Physical Exercise After Childbirth
Official title: The Effect of Physical Exercise on Sleep Quality, Quality of Life and Fatigue in Postpartum Women
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Postpartum
Keywords: exercise
quality of life
fatigue
sleep
postpartum
Lead sponsor: Istanbul University - Cerrahpasa
Sponsor class: OTHER
Collaborators: name: Istanbul University - Cerrahpasa
First posted: 2025-05-25
Enrollment: 108
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: a randomized controlled trial
Primary purpose: PREVENTION

Brief summary: Postpartum women are recommended to engage in physical activity including moderate intensity aerobic and strengthening exercises for at least 150 minutes within one week. The benefits of postpartum exercise include strengthening abdominal muscles, increasing energy, preventing postpartum depression, reducing stress, improving sleep quality and losing excess weight gained during pregnancy. However, activity levels of women who have given birth are reported to be very low, despite the great benefits of exercise on physical and mental health. In a meta-analysis, it was stated that exercise can be used for counseling and therapeutic purposes to improve postpartum quality of life and reduce fatigue.

Detailed description: Although studies evaluating sleep quality, quality of life and fatigue of postpartum women have been found in the literature, no study evaluating the effect of postpartum physical exercise in Turkey has been found yet. Accordingly, this study was planned to evaluate the effect of physical exercise on sleep quality, quality of life and fatigue in postpartum women.

Eligibility criteria: Inclusion Criteria:

* Be over 18 years of age
* Be able to read and write in Turkish
* Be in the 24th postpartum hour
* Have had a vaginal delivery
* Have had a single live birth -Have had a single live birth
* Be primiparous
* Have given birth at term -Have given birth at term
* Accept to participate in the study
* Have no musculoskeletal disorder preventing exercise
* Have no chronic disorder preventing exercise
* Using a smart phone

Exclusion Criteria:

* Having a regular exercise program
* Having a baby in intensive care
* Having a psychiatric treatment in the postpartum period
* Being multiparous
* Willing to voluntarily leave the study
* Did not perform the exercises more than two days in a week

Primary outcomes:
measure: Physical exercise increases sleep quality in postpartum women
timeFrame: 8 week
measure: Physical exercise increases the quality of life in postpartum women
timeFrame: 8 week
measure: Physical exercise reduces fatigue in postpartum women
timeFrame: 8 week
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Istanbul University - Cerrahpasa
name: Tülay YILMAZ
role: STUDY_DIRECTOR
References:
Clinical trial NCT01978509: The Affect of Low-Volume Bowel Preparation for Hospitalized Patients Colonoscopies
Official title: The Affect of Low-Volume Bowel Preparation for Hospitalized Patients Colonoscopies
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Colonoscopy
Keywords: Colonoscopy
Lead sponsor: Mayo Clinic
Sponsor class: OTHER
First posted: 2013-11-07
Enrollment: 32
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: The purpose of this study is to compare the efficacy of a low-volume bowel preparation versus a high-volume bowel preparation for bowel cleansing on hospitalized patients undergoing colonoscopies.


Eligibility criteria: Inclusion criteria:

1. Inpatient colonoscopy
2. Age 18 years and older
3. Able to give consent
4. Split dose colonoscopies for all patients

Exclusion criteria:

1. Unable to give consent
2. Pregnant or lactating women
3. Renal impairment (GFR \<30)
4. Ileus
5. Ascites
6. Toxic megacolon
7. Gastrointestinal obstruction
8. Allergy to study drugs
9. Toxic colitis
10. Not able to split the dose of bowel preparations to be used
11. Contraindication to bowel preparation
12. Risk for aspiration
13. Risk of severe cardiac arrhythmias

Primary outcomes:
measure: Bowel Cleansing
timeFrame: 24 hours
Secondary outcomes:
measure: Cancellation or Delay of Procedure Due to Poor Bowel Preparation
timeFrame: 24 hours
Other outcomes:
measure: Patient Tolerance
timeFrame: 24 hours
measure: Cecal Intubation
timeFrame: 24 hours
Locations:
city: Scottsdale
country: United States
facility: Mayo Clinic in Arizona
state: Arizona
Study officials:
affiliation: Mayo Clinic
name: Francisco Ramirez, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Hernandez PV, Horsley-Silva JL, Snyder DL, Baffy N, Atia M, Koepke L, Buras MR, Lim ES, Ruff K, Umar SB, Islam S, Ramirez FC. Effect of bowel preparation volume in inpatient colonoscopy. Results of a prospective, randomized, comparative pilot study. BMC Gastroenterol. 2020 Jul 13;20(1):227. doi: 10.1186/s12876-020-01373-1.
Clinical trial NCT00205309: Airway IgA: Respiratory Tract IgA Levels in Critically Ill Intubated Patients
Official title: Respiratory Tract IgA Levels in Critically Ill Intubated Patients
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Intubation
Critically Ill
Keywords: intubated patients
Lead sponsor: University of Wisconsin, Madison
Sponsor class: OTHER
First posted: 2005-09-20
Enrollment: 13
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Intubated intensive care patients

Brief summary: This study will examine the impact of acute illness on sequential airway IgA levels in intensive care patients who will require prolonged intubation. Infections are the most common cause of late deaths in non-head injured trauma patients and a frequent cause of morbidity and mortality in hospitalized patients, especially intubated Intensive Care Unit (ICU) patients. Nosocomial pneumonia is the most common of these infections, and its incidence in defined populations of critically injured patients is responsive to route and type of nutrition. This study will focus on the mechanisms of specific immune mucosal defenses in intestinal and extraintestinal sites and link enteral feeding (or lack of it) with maintenance (or deterioration) of respiratory mucosal defenses.


Eligibility criteria: Inclusion Criteria:

* Subjects must be intubated, intensive care patients.

Exclusion Criteria:

* No severe pulmonary contusions or evidence of airway bleeding

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Madison
country: United States
facility: University of Wisconsin Hospital and Clinics
state: Wisconsin
Study officials:
affiliation: University of Wisconsin Medical School
name: Kenneth Kudsk, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01201109: Carpal Tunnel Release in Diabetic Patients
Official title: Five Years Follow-up After Carpal Tunnel Release in Diabetic and Non-diabetic Patients
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Carpal Tunnel Syndrome
Diabetes
Nerve Entrapment
Keywords: Carpal tunnel syndrome
Entrapment neuropathies
Diabetes
Lead sponsor: Skane University Hospital
Sponsor class: OTHER
First posted: 2010-09-14
Enrollment: 66
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Prospective series of matched diabetic and non-diabetic patients who were operated for carapl tunnel syndrome 5 years ago.

Brief summary: The aim of this study is to extend a previously reported 1 year follow-up on carpal tunnel release, in matched diabetic and non-diabetic patients,to compare outcomes 5 years after surgery.

Detailed description: The Follow-up investigation includes:

1. Clinical examination of sensory and motor function
2. Generic and disease specific self-administered questionnaires
3. Nerve conduction study
4. Vibration threshold testing

Eligibility criteria: Inclusion Criteria:

* diabetic and non-diabetic patients operated for carpal tunnel syndrome 5 years ago.

Exclusion Criteria:

* previous carpal tunnel release in the hand under study
* clinical signs of nerve entrapment other than CTS
* cervical radiculopathy, inflammatory joint disease
* renal failure
* thyroid disorders
* previous wrist fracture on the affected side
* daily long-term exposure to vibrating tools
* pregnancy

Primary outcomes:
measure: Patient self-reported outcome questionnaire
timeFrame: 5 years after carpal tunnel release
Secondary outcomes:
measure: Nerve conduction study and vibrotactile sense
timeFrame: 5 years after carpal tunnels release
Other outcomes:
Locations:
city: Malmö
country: Sweden
facility: Dept of Hand Surgery, Skåne University Hospital
Study officials:
name: Lars Dahlin, Md, PhD
role: STUDY_CHAIR
References:
citation: Thomsen NOB, Dahlin LB. Vibrotactile sense 5 years after carpal tunnel release in people with diabetes: A prospective study with matched controls. Diabet Med. 2021 Jul;38(7):e14453. doi: 10.1111/dme.14453. Epub 2020 Nov 26.
Clinical trial NCT05067309: Termination of Early Pregnancy in Scarred Uterus With Lletrozole and Misoprostol Compared to Misoprostol Alone
Official title: Termination of Early Pregnancy in Scarred Uterus With Letrozole and Misoprostol Compared to Misoprostol Alone
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Termination of Early Pregnancy in Scarred Uterus
Lead sponsor: Sohag University
Sponsor class: OTHER
First posted: 2021-10-05
Enrollment: 1
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Termination of early pregnancy in scarred uterus with letrozole and misoprostol compared to Misoprostol alone

Brief summary: Termination of early pregnancy in scarred uterus with letrozole and misoprostol compared to Misoprostol alone


Eligibility criteria: Inclusion Criteria:

* Minimum age of 18 years for mother.

  * Non-viable fetus (missed abortion or blighted ovum) in the 1st trimester of pregnancy evidenced by criteria for diagnosis by TVS .
  * Previous C.S or Myomectomy (1 or more )
  * lack of any maternal diseases such as: heart disease, asthma, history of thromboembolism, cancer, renal failure, and liver diseases.

Exclusion Criteria:

* \* Medical problem in patient

  * Emergency conditions which need intervention .
  * History of allergy to misoprostol or letrozole drugs.

Primary outcomes:
measure: Complete abortion of early pregnancy with letrozole then misoprostol
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Sohag
country: Egypt
facility: Ahmed Elsayed Aref
city: Sohag
country: Egypt
facility: Ahmed Elsayed Aref
Study officials:
References:
Clinical trial NCT03398109: Effectiveness of Toric Intraocular Lenses for Treating Corneal Astigmatism in Patients With Cataract and Previous DALK
Official title: Customized Toric Intraocular Lens Implantation in Eyes With Cataract and Corneal Astigmatism After Deep Anterior Lamellar Keratoplasty (DALK): a Prospective Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Corneal Astigmatism in Cataract Patients and Previous DALK
Lead sponsor: Fondazione G.B. Bietti, IRCCS
Sponsor class: OTHER
First posted: 2018-01-12
Enrollment: 10
Sex: ALL
Minimum age (years): 65
Maximum age (years): 80
Standard ages: OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: the purpose of this study was to assess the efficacy of custom made toric intraocular lens implantation in patients with simultaneous post-DALK high corneal astigmatism and cataract.

Detailed description: Patients undergoing cataract surgery after DALK for keratoconus were enrolled. Total corneal astigmatism (TCA)was assessed by a rotating Scheimpflug camera combined with Placido disk corneal topography (Sirius; CSO, Firenze, Italy). A customized toric IOL (FIL 611 T, Soleko) was implanted in all eyes. One year postoperatively, refraction was measured, the IOL position was recorded, and vectorial and non-vectorial analysis were performed to evaluate the correction of astigmatism.

Eligibility criteria: Inclusion Criteria:

* Corneal suture removal had been performed in all cases at least 1 year before cataract surgery.

Corneal astigmatism was stable at least since 6 months before the cataract surgery

Exclusion Criteria:

* other ocular pathologies as glaucoma, retinal disease.

Primary outcomes:
measure: Measure postoperative refractive astigmatism
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Fondazione G.B. Bietti
name: Domenico Schiano-Lomoriello, MD
role: STUDY_DIRECTOR
References:
citation: Schiano Lomoriello D, Savini G, Naeser K, Colabelli-Gisoldi RM, Bono V, Pocobelli A. Customized Toric Intraocular Lens Implantation in Eyes with Cataract and Corneal Astigmatism after Deep Anterior Lamellar Keratoplasty: A Prospective Study. J Ophthalmol. 2018 Jul 3;2018:1649576. doi: 10.1155/2018/1649576. eCollection 2018.
Clinical trial NCT06437756: Effects of Theraband Resistance Training on Muscle Strength in Coronary Artery Diseases
Official title: Effects of Theraband Resistance Training on Muscle Strength in Coronary Artery Diseases
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Coronary Artery Disease
Lead sponsor: Riphah International University
Sponsor class: OTHER
First posted: 2024-05-31
Enrollment: 38
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: To compare the effects of Theraband Resistance Training with Conventional Resistance Training on muscle strength in coronary artery diseases


Eligibility criteria: Inclusion Criteria:

* Participants having a documented diagnosis of CAD, confirmed by a medical professional.
* Individuals with a history of myocardial infarction (heart attack), angina, or evidence of significant coronary artery stenosis.
* Stable CAD who were not experiencing acute coronary events, such as recent heart attacks or unstable angina.
* Patients who were able to perform exercises with TheraBand.
* Reduced muscle strength of upper limb/lower limb

Exclusion Criteria:

* Patients over the age of 75 years.
* Exclude individuals with a recent history of Theraband resistance training.
* Severe cardiovascular complications such as heart failure with reduced ejection fraction, severe arrhythmias, or uncontrolled hypertension.
* Patients with unstable conditions or cardiac episodes.
* Individuals who had undergone major cardiovascular surgery (e.g., coronary artery bypass grafting) within the last six months.
* Ejection fraction \< 40%

Primary outcomes:
measure: Hand Held Dynamometer
timeFrame: 6 week
measure: Modified BORG Scale
timeFrame: 6 week
measure: Chadler Fatigue Scale
timeFrame: 6 week
measure: 6 Min walk test (Distance in meters)
timeFrame: 6 week
measure: The 30 Second Sit to Stand Test(30SSST) for lower limb strength
timeFrame: 6 week
Secondary outcomes:
Other outcomes:
Locations:
city: Islamabad
country: Pakistan
facility: Al Nafees Medical Hospital
state: Federal
Study officials:
affiliation: Riphah International University
name: Muhammad Iqbal Tariq, PhD*
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00547456: Consequences of Nocturnal and Daytime Hypoxemia in COPD
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Chronic Obstructive Pulmonary Disease
Lead sponsor: Northwell Health
Sponsor class: OTHER
First posted: 2007-10-22
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SUPPORTIVE_CARE

Brief summary: We will determine whether oxygen therapy lowers the level of substances in the blood which cause inflammation, which is one of the adverse effects of COPD and whether oxygen improves overall well being and quality of life as well as sleep quality.

Detailed description: Hypothesis: Isolated nocturnal hypoxemia contributes to chronic systemic inflammation in COPD by activating circulating neutrophils.

Eligibility criteria: Inclusion Criteria:

* Adult males or females with a diagnosis of COPD screened for nocturnal desaturation as indicated above.
* Clinical stability defined by absence of treatment change or need for acute care within the last two months.
* Weight stable, within 5%, in the previous three months as measured during office visits.
* Willingness to participate in a clinical study.

Exclusion Criteria:

* Acute illness within the preceding 2 months.
* Patients who received systemic glucocorticoid therapy within the past month.
* Clinical and/or overnight pulse oximetry evidence of obstructive sleep apnea (OSA). The Multivariate Apnea Prediction Questionnaire (MAP) will be given to all patients to assess the likelihood of OSA based on common symptoms of this disorder. While we recognize that this screening instrument was not evaluated specifically in COPD patients, it assesses common signs and symptoms of OSA. This tool has been shown to identify OSA with 95% sensitivity (63). In addition, the ODI 4% will be determined from the overnight pulse oximetry recording. Patients will be excluded if the MAP score is \> 0.4 or if the ODI 4% is \>15/hour, which is suggestive of the concomitant presence of obstructive sleep apnea.
* Hypercapnia defined as PaCO2 \> 50 mmHg on resting arterial blood gas
* Previous diagnosis of erythrocytosis, pulmonary vascular disease, pleural effusions, ischemic heart disease or congestive heart failure.
* No chronic illnesses known to affect the inflammatory response such as infection, collagen vascular disease, liver disease, thyroid disease or diabetes.
* Primary care or pulmonary physician refusal.
* Patient refusal for any reason.
* Lack of capacity to participate in the informed consent process.

Primary outcomes:
measure: Demonstration of Improvement in Systemic Inflammation, Sleep Quality and Health Related Quality of Life With Nocturnal Oxygen Supplementation.
timeFrame: 4 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: New Hyde Park
country: United States
facility: North Shore LIJ Health System
state: New York
Study officials:
affiliation: Northwell Health
name: Rubin Cohen, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04019756: IDENTIFICATION OF URINARY MICROBIOTE IN PATIENTS WITH DIAGNOSTIC-RELATED CYSTOSCOPY
Official title: IDENTIFICATION OF URINARY MICROBIOTE IN PATIENTS WITH DIAGNOSTIC-RELATED CYSTOSCOPY
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Cystoscopy
Lead sponsor: Assistance Publique Hopitaux De Marseille
Sponsor class: OTHER
First posted: 2019-07-15
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: OTHER
Sampling method: PROBABILITY_SAMPLE
Study population: Any present patient meeting the inclusion criteria of the study will be offered to participate in the study. For this purpose during the hospitalization or consultation of the patient, the investigator or his collaborator.

Brief summary: Identify by culture the urinary microbiota of patients with bladder cancer (at the time of diagnosis) and controls.Identify by metagenomics the urinary microbiota of patients with bladder cancer (at the time of diagnosis) and controls.

Detailed description: Relationships between the human microbiota and various pathologies such as cancer have been demonstrated. The microbiota would have an influence on the effectiveness of anticancer treatments.

Bladder cancers are five times more common in men than women, and this difference in incidence has long been explained by a higher smoking rate among men. However, the increase in smoking among women has not led, as in the case of lung cancer, to a significant increase in bladder cancer among them.

Urine bladder has long been considered "sterile" by generations of researchers. Recent studies have shown that most urine is not sterile but instead contains a different microbiota in both men and women. In women Actinobacteria, including Mycobacteria, and Bacteroidetes have been detected.

BCG therapy is used in the treatment of bladder cancer. BCG, in addition to being a vaccine to prevent tuberculosis, is a mycobacterium belonging to the phylum Actinobacteria \[4\]. Controversial studies have suggested the same potential for Lactobacillus casei. Lactobacillii are Firmicutes found both in the urinary microbiota of men and women.

Thus microbiota composed mainly of Actinobacteria could be associated with a lower incidence of bladder cancers in women.

Eligibility criteria: Inclusion Criteria:

* Person receiving a cystoscopy in the context of a suspicion of bladder cancer
* Person and / or legal guardian for minors who have been informed about the study and have not expressed opposition to participate in the study.
* Affiliated person or beneficiary of a social security scheme.

Exclusion Criteria:

* Vulnerable person: pregnant, parturient or nursing woman,
* person under guardianship or curatorship, or deprived of liberty by a judicial or administrative decision.
* Person treated with antibiotics

Primary outcomes:
measure: Matrix Assisted Laser Desorption Ionisation - Time of Flight
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References: