Clinical trial NCT00625898: BETH Study: Treatment of HER2 Positive Breast Cancer With Chemotherapy Plus Trastuzumab vs Chemotherapy Plus Trastuzumab Plus Bevacizumab
Official title: A Multicenter Phase III Randomized Trial of Adjuvant Therapy for Patients With HER2-Positive Node-Positive or High Risk Node-Negative Breast Cancer Comparing Chemotherapy Plus Trastuzumab With Chemotherapy Plus Trastuzumab Plus Bevacizumab
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE3
Conditions: Breast Cancer
Keywords: HER2 positive breast cancer
invasive breast cancer
bevacizumab
NSABP
Roche
CIRG
trastuzumab
cyclophosphamide
docetaxel
carboplatin
5-fluorouracil
epirubicin
Lead sponsor: NSABP Foundation Inc
Sponsor class: NETWORK
Collaborators: name: Cancer International Research Group (CIRG)
name: Hoffmann-La Roche
name: Genentech, Inc.
First posted: 2008-02-29
Enrollment: 3509
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The trial will determine the value of adding bevacizumab to chemotherapy plus trastuzumab in patients with resected node-positive or high risk node-negative, HER2-positive breast cancer.

Detailed description: This Phase III, randomized, open-label trial will determine whether the regimens of chemotherapy plus trastuzumab plus bevacizumab improve invasive disease-free survival (IDFS) relative to the regimens of chemotherapy plus trastuzumab. Secondary aims include determining whether the addition of bevacizumab to chemotherapy plus trastuzumab will improve disease-free survival (DFS), overall survival (OS), recurrence-free interval (RFI), and distant recurrence-free interval (DRFI). The benefit of adding bevacizumab for IDFS, DFS, OS, RFI, and DRFI will also be evaluated for each of the two chemotherapy regimens. The cardiac and non-cardiac toxicities of each of the regimens will also be evaluated.

Following local determination that the tumor is HER2-positive for gene amplification by in situ hybridization or is IHC 2+ or 3+, a tumor sample must be submitted for HER2 testing by a designated central laboratory. If central testing confirms that the tumor is HER2-positive (either positive by FISH or IHC 3+) and all other eligibility criteria have been met, the patient will be randomized to a regimen of chemotherapy and trastuzumab with or without bevacizumab.

Patients in the trial will be enrolled in one of two chemotherapy regimen cohorts. One cohort will receive 6 cycles of docetaxel/carboplatin plus trastuzumab (TCH) with or without bevacizumab; the other cohort will receive 3 cycles of docetaxel plus trastuzumab given with or without bevacizumab followed by 3 cycles of 5-Fluorouracil, Epirubicin, Cyclophosphamide (TH-FEC). With both regimens, patients will continue trastuzumab with or without bevacizumab following chemotherapy to complete 1 year of targeted therapy. Following completion of chemotherapy, patients will also receive adjuvant radiotherapy and endocrine therapy as clinically indicated.

The trial will be conducted by investigators affiliated with the Cancer International Research Group (CIRG) and the National Surgical Adjuvant Breast and Bowel Project (NSABP). CIRG and NSABP investigators will only enroll patients in the TCH regimen cohort. Additional investigators, referred to in the protocol as Independent Investigators, will enroll patients in both the TCH regimen or the TH-FEC regimen cohort depending on institutional preference for the one regimen that will be used by that institution for the duration of the trial.

Patients will be given the option of allowing their tumor samples to be used for the BETH translational research and correlative science studies. Also, patients will be asked to consent to the submission of blood and serum samples at scheduled time points during the study.

LVEF assessments will be performed before study entry and then at scheduled time points during therapy and at 18, 36, and 60 months following randomization.

The planned sample size for the trial is 3,000 patients randomized in the faster accruing cohort and a minimum of 3,500 patients overall.

Eligibility criteria: Inclusion Criteria:

* Life expectancy of at least 10 years, excluding their diagnosis of breast cancer.
* Women who have had breast reconstruction utilizing tissue expanders must be in agreement with delaying surgery to replace the tissue expanders with permanent implants until 3 months following the last dose of bevacizumab
* Women of reproductive potential must agree to use an effective non-hormonal method of contraception (for example condoms, some intrauterine devices, diaphragms, vasectomized partner, or abstinence) during therapy and for at least 6 months after the last dose of bevacizumab and/or trastuzumab.
* Submission of tumor samples from the breast surgery for central HER2 testing is required for all patients prior to enrollment in the BETH Trial
* Signed and dated IRB/EC-approved consent
* ECOG performance status of 0 or 1
* The tumor must be unilateral invasive adenocarcinoma of the breast on histologic examination.
* The breast cancer must be HER2-positive based on test results as follows: Local testing (if available) should demonstrate that the tumor is IHC 2+ or 3+ or is considered to be HER2-positive for gene amplification by FISH, CISH, or other in situ hybridization (ISH) method. If local ISH test results are considered equivocal, the tumor can be submitted for central HER2 testing. (If local testing is not possible, the tumor can be submitted for central HER2 testing.) Central testing (a requirement for ALL patients) must demonstrate that the tumor is HER2-positive which is defined as FISH-positive and/or IHC 3+.
* All of the following staging criteria (according to the 6th edition of the AJCC Cancer Staging Manual) must be met: By pathologic evaluation, primary tumor must be pT1-3; By pathologic evaluation, ipsilateral nodes must be pN0, pN1 (pN1mi, pN1a, pN1b, pN1c), pN2a, pN3a, or pN3b. If pN0, at least one of the following criteria must be met: Pathologic tumor size \> 2.0 cm; ER negative and PgR negative; Histologic and/or nuclear grade 2 (intermediate) or 3 (high); or Age \< 35 years
* Patients must have undergone either a total mastectomy or breast conserving surgery (lumpectomy).
* For patients who undergo lumpectomy, the margins of the resected specimen must be histologically free of invasive tumor and ductal carcinoma in situ (DCIS) as determined by the local pathologist. If pathologic examination demonstrates tumor at the line of resection, additional operative procedures may be performed to obtain clear margins. If tumor is still present at the resected margin after re-excision(s), the patient must undergo total mastectomy to be eligible. (Patients with margins positive for lobular carcinoma in situ \[LCIS\] are eligible without additional resection.)
* For patients who undergo mastectomy, margins must be free of gross residual tumor. Patients with microscopic positive margins are eligible.
* Patients must have completed one of the following procedures for evaluation of pathologic nodal status: Sentinel lymphadenectomy followed by removal of additional non-sentinel lymph nodes if the sentinel node (SN) is positive; Sentinel lymphadenectomy alone if pathologic nodal staging based on sentinel lymphadenectomy is pN0, pN1mi or pN1b; or Axillary lymphadenectomy without SN isolation procedure.
* The interval between the last surgery for breast cancer (treatment or staging) and randomization must be at least 28 days but no more than 84 days.
* Patients must have ER analysis performed on the primary tumor prior to randomization. If ER analysis is negative, then PgR analysis must also be performed.
* The most recent postoperative blood counts, performed within 6 weeks prior to randomization, must meet the following criteria: ANC must be greater than or equal to 1200/mm3; Platelet count must be greater than or equal to 100,000/mm3; and Hemoglobin must be greater than or equal to 10 g/dL.
* The following criteria for evidence of adequate hepatic function must be met based on the results of the most recent postoperative tests performed within 6 weeks prior to randomization: total bilirubin must be less than or equal to upper limit of normal (ULN) for the lab unless the patient has a bilirubin elevation \> ULN to 1.5 x ULN due to Gilbert's disease or similar syndrome involving slow conjugation of bilirubin; and alkaline phosphatase must be less than or equal to 2.5 x ULN for the lab; and AST must be less than or equal to 1.5 x ULN for the lab. Alkaline phosphatase and AST may not both be \> the ULN.
* Patients with AST or alkaline phosphatase \> ULN are eligible for inclusion in the study if liver imaging (CT, MRI, PET scan, or PET-CT scan performed within 3 months prior to randomization) does not demonstrate metastatic disease and the requirements for evidence of adequate hepatic function are met.
* Patients with alkaline phosphatase that is \> ULN but less than or equal to 2.5 x ULN are eligible for inclusion in the study if a bone scan,PET scan, or PET-CT scan (performed within 3 months prior to randomization) does not demonstrate metastatic disease.
* The following criteria for renal function must be met based on the results of the most recent postoperative tests performed within 6 weeks prior to randomization: Serum creatinine must be less than or equal to ULN for the lab. Measured or calculated creatinine clearance must be \> 60 mL/min.
* A urine sample must be tested for protein by determination of the urine protein/creatinine (UPC) ratio or by urine dipstick. UPC ratio must be less than 1.0. Urine dipstick must indicate 0-1+ protein. If dipstick reading is greater than or equal to 2+, determine the UPC ratio, which must be less than 1.0, or collect a 24-hour urine specimen, which must demonstrate \< 1.0 g of protein per 24 hours.
* LVEF assessment must be performed within 3 months prior to randomization. The LVEF must be greater than or equal to 55% regardless of the cardiac imaging facility's lower limit of normal (LLN).
* The ECG (performed within 3 months prior to randomization) must not have demonstrated any of the following conditions: ventricular arrhythmias except for benign premature ventricular contractions; supraventricular and nodal arrhythmias requiring a pacemaker or not controlled with medication; and conduction abnormality requiring a pacemaker.

Exclusion Criteria:

* Inflammatory breast cancer.
* Definitive clinical or radiologic evidence of metastatic disease. (Chest imaging \[mandatory for all patients\] and other imaging \[if required\] must have been performed within 3 months prior to randomization.)
* Synchronous or previous contralateral invasive breast cancer (Patients with synchronous or previous contralateral DCIS or LCIS are eligible).
* History of ipsilateral invasive breast cancer regardless of treatment or ipsilateral DCIS treated with excision and RT. (Patients with history of ipsilateral LCIS are eligible.)
* History of non-breast malignancies within the 5 years prior to study entry, except for the following: carcinoma in situ of the cervix, carcinoma in situ of the colon, melanoma in situ, and basal cell and squamous cell carcinomas of the skin.
* Previous therapy with anthracyclines, taxanes, carboplatin, trastuzumab, or bevacizumab for any malignancy.
* RT, chemotherapy, and/or targeted therapy, administered for the currently diagnosed breast cancer prior to randomization.
* Continued therapy with any hormonal agent such as raloxifene or tamoxifen (or other SERM) or an aromatase inhibitor. (Patients are eligible if these medications are discontinued prior to randomization.)
* Any sex hormonal therapy, e.g., birth control pills, ovarian hormone replacement therapy, etc. Patients are eligible if these medications are discontinued prior to randomization.
* Cardiac disease (history of and/or active disease) that would preclude the use of the drugs included in the treatment regimens. This includes but is not confined to: Active cardiac disease - angina pectoris that requires the use of anti-anginal medication; ventricular arrhythmias except for benign premature ventricular contractions; supraventricular and nodal arrhythmias requiring a pacemaker or not controlled with medication; conduction abnormality requiring a pacemaker; valvular disease with documented compromise in cardiac function; and symptomatic pericarditis. History of cardiac disease - myocardial infarction documented by elevated cardiac enzymes or persistent regional wall abnormalities on assessment of LV function; history of documented CHF; and documented cardiomyopathy.
* Uncontrolled hypertension defined as systolic blood pressure (BP) \> 150 mmHg or diastolic BP \> 90 mmHg, with or without anti-hypertensive medication. (BP must be assessed within 28 days prior to randomization.) Patients with initial BP elevations are eligible if initiation or adjustment of BP medication lowers pressure to meet entry criteria.
* History of hypertensive crisis or hypertensive encephalopathy.
* History of TIA or CVA.
* History of any arterial thrombotic event within 12 months before randomization.
* Symptomatic peripheral vascular disease.
* Intrinsic lung disease resulting in dyspnea.
* Unstable diabetes mellitus.
* Active infection or chronic infection requiring chronic suppressive antibiotics.
* Any significant bleeding within 6 months before randomization, exclusive of menorrhagia in premenopausal women.
* Non-healing wound, skin ulcers, or incompletely healed bone fracture.
* Major surgical procedure, open biopsy, or significant traumatic injury within 28 days prior to planned start of study therapy.
* Anticipation of need for major surgical procedures during study therapy and for at least 3 months following completion of bevacizumab.
* Gastroduodenal ulcer(s) documented by endoscopy to be active within 6 months before randomization.
* History of GI perforation, abdominal fistulae, or intra-abdominal abscess.
* Known bleeding diathesis or coagulopathy.
* Requirement for therapeutic doses of coumadin or equivalent.
* Sensory/motor neuropathy greater than or equal to grade 2, as defined by the NCI CTCAE v3.0.
* Conditions that would prohibit administration of corticosteroids.
* Chronic daily treatment with corticosteroids (dose of \> 10 mg/day methylprednisolone equivalent) (excluding inhaled steroids).
* History of hypersensitivity reaction to drugs formulated with polysorbate 80.
* Pregnancy or lactation at the time of study entry. (Note: Pregnancy testing must be performed within 14 days prior to randomization according to institutional standards for women of child-bearing potential.)
* Other non-malignant systemic disease that would preclude the patient from receiving study treatment or would prevent required follow-up.
* Psychiatric or addictive disorders or other conditions that, in the opinion of the investigator, would preclude the patient from meeting the study requirements.
* Use of any investigational product within 4 weeks prior to enrollment in the study.

Primary outcomes:
measure: Invasive Disease-free Survival (IDFS)
timeFrame: up to 10 years
Secondary outcomes:
measure: Invasive disease-free survival (IDFS) within chemotherapy cohorts
timeFrame: up to 10 years
measure: Disease-free survival (DFS)
timeFrame: up to 10 years
measure: Overall survival (OS)
timeFrame: Time from randomization until death from any cause or up to a maximum of 10 years from study entry
measure: Recurrence-free interval (RFI)
timeFrame: Time from randomization until local, regional or distant recurrence or up to a maximum of 10 years from study entry
measure: Distant recurrence-free interval (DRFI)
timeFrame: Time from randomization until distant disease recurrence only or up to a maximum of 10 years from study entry
measure: Cardiac toxicity. Cumulative incidence of severe cardiac events defined as definite or probable cardiac death, or NYHA Class III or IV CHF
timeFrame: 2-3 weeks after cycle 3; 2-3 weeks after last chemotherapy dose; 7, 10, 18, 36, and 60 months from randomization
measure: Non-cardiac toxicity. Frequencies of adverse events categorized using the NCI CTCAE v3.0.
timeFrame: within 3 days of each chemotherapy cycle; 2-3 weeks following last chemotherapy dose; every 6 weeks during targeted therapy; every 6 months through year 5; every 12 months years 6 - 10
measure: Identification of biomarkers (from tumor and serum/plasma) predictive for the level of benefit from the addition of bevacizumab to standard adjuvant systemic treatment for HER2-positive breast cancer as well as for cardiac toxicity
timeFrame: baseline, during therapy and follow-up, within 2 weeks of LVEF assessments, any protocol-specified cardiac event, and after diagnosis of recurrence
Other outcomes:
Locations:
city: Birmingham
country: United States
facility: University of Alabama at Birmingham
state: Alabama
city: Decatur
country: United States
facility: Clearview Cancer Institute-Decatur
state: Alabama
city: Huntsville
country: United States
facility: Clearview Cancer Institute
state: Alabama
city: Huntsville
country: United States
facility: Clearview Cancer Institute- Huntsville
state: Alabama
city: Flagstaff
country: United States
facility: Northern Arizona Hematology & Onclogy Associates
state: Arizona
city: Sedona
country: United States
facility: Northern Arizona Hematology & Oncology Associates
state: Arizona
city: Alhambra
country: United States
facility: Central Hematology/Oncology Medical Group, Inc.
state: California
city: Bakersfield
country: United States
facility: Comprehensive Blood and Cancer Center
state: California
city: Baldwin Park
country: United States
facility: Kaiser Permanente-Baldwin Park
state: California
city: Bellflower
country: United States
facility: Kaiser Permanente-Bellflower
state: California
city: Burbank
country: United States
facility: Providence Saint Joseph Medical Center
state: California
city: Encinitas
country: United States
facility: Hematology-Encinitas
state: California
city: Encinitas
country: United States
facility: Scripps Clinic Encinitas
state: California
city: Fontana
country: United States
facility: Kaiser Permanente-Fontana
state: California
city: Fullerton
country: United States
facility: St. Jude Heritage Healthcare
state: California
city: Hawthorne
country: United States
facility: Breastlink Medical Group, Inc
state: California
city: Huntington Beach
country: United States
facility: Pacific Shores Medical Group
state: California
city: Irvine
country: United States
facility: Kaiser Permanente-Irvine
state: California
city: La Jolla
country: United States
facility: Hematology-La Jolla
state: California
city: La Jolla
country: United States
facility: Sabina R. Wallach, MD., AMC
state: California
city: La Jolla
country: United States
facility: Scripps Cancer Center-San Diego
state: California
city: Lancaster
country: United States
facility: Antelope Valley Cancer Center
state: California
city: Los Angeles
country: United States
facility: Kaiser Permanente-Sunset
state: California
city: Los Angeles
country: United States
facility: Kaiser Permanente-West Los Angeles
state: California
city: Oakland
country: United States
facility: Kaiser Permanente-Oakland
state: California
city: Oceanside
country: United States
facility: North County Oncology Medical Clinic, Inc.
state: California
city: Panorama City
country: United States
facility: Kaiser Permanente-Panorama City
state: California
city: Panorama City
country: United States
facility: Kaiser Permanente-Orange County
state: California
city: Pasadena
country: United States
facility: Wilshire Oncology Medical Group
state: California
city: Redondo Beach
country: United States
facility: Cancer Care Associates Medical Group, Inc.
state: California
city: Riverside
country: United States
facility: Kaiser Permanente-Riverside
state: California
city: Roseville
country: United States
facility: Kaiser Permanente-Roseville
state: California
city: Roseville
country: United States
facility: Sutter Roseville Medical Center
state: California
city: Roseville
country: United States
facility: Kaiser Permanente-Sacramento
state: California
city: Sacramento
country: United States
facility: Sutter Medical Center
state: California
city: Sacramento
country: United States
facility: Sutter Medical Group
state: California
city: San Diego
country: United States
facility: Peter T. Reissman, MD, Inc
state: California
city: San Diego
country: United States
facility: William Stanton, MD, Inc
state: California
city: San Diego
country: United States
facility: Kaiser Permanente-San Diego
state: California
city: San Diego
country: United States
facility: Sharp Rees-Stealy
state: California
city: San Diego
country: United States
facility: Scripps Clinic-Rancho Bernardo
state: California
city: San Francisco
country: United States
facility: Kaiser Permanente-San Francisco
state: California
city: San Francisco
country: United States
facility: Kaiser Permanente-Hayward
state: California
city: Santa Barbara
country: United States
facility: Sansum Clinic
state: California
city: Santa Barbara
country: United States
facility: Santa Barbara Hematology Oncology Medical Group
state: California
city: Santa Clara
country: United States
facility: Kaiser Permanente-Santa Clara
state: California
city: Santa Maria
country: United States
facility: Central Coast Medical Oncology Corporation
state: California
city: South San Francisco
country: United States
facility: Kaiser Permanente-South San Francisco
state: California
city: Stanford
country: United States
facility: Stanford University Medical Center
state: California
city: Valencia
country: United States
facility: UCLA/Santa Clarita Valley Cancer Center
state: California
city: Vallejo
country: United States
facility: Kaiser Permanente-Vallejo
state: California
city: Vista
country: United States
facility: San Diego Pacific Oncology & Hematology-Vista
state: California
city: Walnut Creek
country: United States
facility: Kaiser Permanente-Walnut Creek
state: California
city: Woodland Hills
country: United States
facility: Kaiser Permanente-Woodland Hills
state: California
city: Aurora
country: United States
facility: University of Colorado Cancer Center
state: Colorado
city: Colorado Springs
country: United States
facility: Penrose Cancer Center
state: Colorado
city: Denver
country: United States
facility: Kaiser Permanente-Franklin
state: Colorado
city: Denver
country: United States
facility: Cypress Hematology/Oncology
state: Colorado
city: Denver
country: United States
facility: Rocky Mountain Cancer Center - Midtown
state: Colorado
city: Denver
country: United States
facility: CCOP-Colorado Cancer Research Prog. Inc.(Administrative Only)
state: Colorado
city: Edwards
country: United States
facility: Shaw Regional Cancer Center
state: Colorado
city: Greeley
country: United States
facility: North Colorado Medical Center
state: Colorado
city: Lafayette
country: United States
facility: Kaiser Permanente Rock Creek
state: Colorado
city: Loveland
country: United States
facility: McKee Medical Center
state: Colorado
city: Wheat Ridge
country: United States
facility: Exempla Lutheran Medical Center
state: Colorado
city: Avon
country: United States
facility: Oncology Associates P.C.-Avon
state: Connecticut
city: Bridgeport
country: United States
facility: Medical Specialists of SWIM
state: Connecticut
city: Bridgeport
country: United States
facility: Bridgeport Hospital
state: Connecticut
city: Fairfield
country: United States
facility: Medical Specialists of Fairfield
state: Connecticut
city: Fairfield
country: United States
facility: Oncology Associates of Bridgeport-Fairfield
state: Connecticut
city: Hartford
country: United States
facility: Hartford Hospital
state: Connecticut
city: Hartford
country: United States
facility: Connecticut Multi Specialty Group-Hartford
state: Connecticut
city: Hartford
country: United States
facility: Oncology Associates P.C.-Hartford
state: Connecticut
city: Meriden
country: United States
facility: Medical Oncology and Hematology, P.C.
state: Connecticut
city: Norwich
country: United States
facility: Eastern Connecticut Hematology & Oncology Associates
state: Connecticut
city: Trumbull
country: United States
facility: Black Rock Medical Group
state: Connecticut
city: Trumbull
country: United States
facility: Oncology Associates of Bridgeport-Trumbull
state: Connecticut
city: Waterbury
country: United States
facility: Medical Oncology & Hematology, P.C.
state: Connecticut
city: Wethersfield
country: United States
facility: Connecticut Multi Specialty Group-Wethersfield
state: Connecticut
city: Willimantic
country: United States
facility: Oncology Associates P.C.-Willimantic
state: Connecticut
city: Newark
country: United States
facility: CCOP, Christiana Care Health Services Inc.
state: Delaware
city: Washington
country: United States
facility: Washington Cancer Institute
state: District of Columbia
city: Washington
country: United States
facility: Sibley Memorial Hospital
state: District of Columbia
city: Washington
country: United States
facility: Washington Oncology-Hematology Center, PC-Washington
state: District of Columbia
city: Boca Raton
country: United States
facility: Lynn Cancer Institute
state: Florida
city: Bonita Springs
country: United States
facility: Florida Cancer Specialists-Bonita Springs
state: Florida
city: Bradenton
country: United States
facility: Florida Cancer Specialists-Bradenton
state: Florida
city: Brandon
country: United States
facility: Florida Cancer Specialists, Brandon
state: Florida
city: Cape Coral
country: United States
facility: Florida Cancer Specialists-Cape Coral Parkway
state: Florida
city: Cape Coral
country: United States
facility: Florida Cancer Specialists-Cape Coral Del Prado
state: Florida
city: Clearwater
country: United States
facility: Florida Cancer Specialists
state: Florida
city: Englewood
country: United States
facility: Florida Cancer Specialists-Englewood
state: Florida
city: Fort Myers
country: United States
facility: Florida Cancer Specialists-Fort Myers Broadway
state: Florida
city: Fort Myers
country: United States
facility: Florida Cancer Specialists-Fort Myers Summerlin
state: Florida
city: Gainesville
country: United States
facility: Robert R. Carroll, MD, PA
state: Florida
city: Jacksonville
country: United States
facility: Integrated Community Oncology Network
state: Florida
city: Lakeland
country: United States
facility: Lakeland Regional Cancer Center
state: Florida
city: Naples
country: United States
facility: Florida Cancer Specialists-Naples Goodlette
state: Florida
city: Naples
country: United States
facility: Florida Cancer Specialists-NAPA Ridge
state: Florida
city: Orange Park
country: United States
facility: Integrated Community Oncology Network
state: Florida
city: Orlando
country: United States
facility: Florida Hospital Cancer Institute
state: Florida
city: Palm Harbor
country: United States
facility: Florida Cancer Specialists, Cornerstone
state: Florida
city: Port Charlotte
country: United States
facility: Florida Cancer Specialists-Port Charlotte
state: Florida
city: Saint Petersburg
country: United States
facility: Florida Cancer Specialists-Park Place
state: Florida
city: Sarasota
country: United States
facility: Florida Cancer Specialist-Cattleman
state: Florida
city: Sarasota
country: United States
facility: Florida Cancer Specialists-Downtown
state: Florida
city: Tampa
country: United States
facility: Florida Cancer Specialists
state: Florida
city: Tampa
country: United States
facility: Florida Cancer Specialists
state: Florida
city: Venice
country: United States
facility: Florida Cancer Specialists-Venice Island
state: Florida
city: Venice
country: United States
facility: Florida Cancer Specialists-Venice
state: Florida
city: West Palm Beach
country: United States
facility: Palm Beach Cancer Institute
state: Florida
city: Albany
country: United States
facility: Phoebe Putney Memorial Hospital
state: Georgia
city: Athens
country: United States
facility: Northeast Georgia Cancer Care, LLC
state: Georgia
city: Atlanta
country: United States
facility: Grady Healthsystem
state: Georgia
city: Atlanta
country: United States
facility: Emory University
state: Georgia
city: Augusta
country: United States
facility: Augusta Oncology Associates
state: Georgia
city: Austell
country: United States
facility: Northwest Georgia Oncology Centers PC
state: Georgia
city: Carrollton
country: United States
facility: Northwest Georgia Oncology Centers PC
state: Georgia
city: Cartersville
country: United States
facility: Northwest Georgia Oncology Centers PC
state: Georgia
city: Lawrenceville
country: United States
facility: Suburban Hematology-Oncology Associates
state: Georgia
city: Macon
country: United States
facility: Central Georgia Cancer Care
state: Georgia
city: Macon
country: United States
facility: Georgia Cancer Specialists
state: Georgia
city: Marietta
country: United States
facility: Georgia Cancer Specialists
state: Georgia
city: Snellville
country: United States
facility: Suburban Hematology Oncology Associates PC
state: Georgia
city: Honolulu
country: United States
facility: Oncare Hawaii, Inc-POB2
state: Hawaii
city: Honolulu
country: United States
facility: Straub Clinic and Hospital
state: Hawaii
city: Honolulu
country: United States
facility: University of Hawaii
state: Hawaii
city: Honolulu
country: United States
facility: Oncare Hawaii, Inc-KMP
state: Hawaii
city: Coeur d'Alene
country: United States
facility: Kootenai Cancer Center
state: Idaho
city: Meridian
country: United States
facility: Mountain States Tumor Institute
state: Idaho
city: Twin Falls
country: United States
facility: Mountain States Tumor Institute
state: Idaho
city: Arlington
country: United States
facility: Cancer Care & Hematology Specialists of Chicagoland
state: Illinois
city: Chicago
country: United States
facility: MBCCOP, John H. Stroger, JR., Hospital of Cook County-Chicago
state: Illinois
city: Chicago
country: United States
facility: Rush University Medical Center
state: Illinois
city: Decatur
country: United States
facility: Crossroads Cancer Center
state: Illinois
city: Decatur
country: United States
facility: Cancer Care Specialists-Central Illinois
state: Illinois
city: Decatur
country: United States
facility: Decatur Memorial Hospital
state: Illinois
city: Naperville
country: United States
facility: Edward Hospital
state: Illinois
city: Plainfield
country: United States
facility: Edward Cancer Center Plainfield
state: Illinois
city: Winfield
country: United States
facility: Cancer Care and Hematology Specialists of Chicagoland
state: Illinois
city: Yorkville
country: United States
facility: Yorkville Family Practice
state: Illinois
city: Bloomington
country: United States
facility: Cancer Care of Southern Indiana
state: Indiana
city: Corydon
country: United States
facility: Corydon Hospital Medical Plaza
state: Indiana
city: Elkhart
country: United States
facility: Elkhart Clinic
state: Indiana
city: Elkhart
country: United States
facility: Michiana Hematology-Oncology, P.C. (Elkhart)
state: Indiana
city: Gary
country: United States
facility: Waverly Hematology Oncology
state: Indiana
city: Jeffersonville
country: United States
facility: Clark Medical Building
state: Indiana
city: Kokomo
country: United States
facility: Howard Regional Health System
state: Indiana
city: LaPorte
country: United States
facility: Michiana Hematology-Oncology, P.C. (LaPorte)
state: Indiana
city: New Albany
country: United States
facility: Cancer Care Center
state: Indiana
city: Plymouth
country: United States
facility: Michiana Hematology-Oncology PC
state: Indiana
city: Plymouth
country: United States
facility: Oncology, P.C. Plymouth
state: Indiana
city: South Bend
country: United States
facility: South Bend Clinic
state: Indiana
city: South Bend
country: United States
facility: Michiana Hematology-Oncology, P.C. (Main Office)
state: Indiana
city: South Bend
country: United States
facility: Northern Indiana Cancer Research Consortium
state: Indiana
city: South Bend
country: United States
facility: Michiana Hematology-Oncology, P.C. Cedar St.
state: Indiana
city: Terre Haute
country: United States
facility: Providence Medical Group
state: Indiana
city: Bettendorf
country: United States
facility: Hematology and Medical Oncology Consultants-Bettendorf
state: Iowa
city: Davenport
country: United States
facility: Hematology and Medical Oncology Consultants-Davenport
state: Iowa
city: Iowa City
country: United States
facility: University of Iowa
state: Iowa
city: Lawrence
country: United States
facility: Lawrence Memorial Hospital
state: Kansas
city: Lexington
country: United States
facility: University of Kentucky Medical Center
state: Kentucky
city: Louisville
country: United States
facility: NortonHealthcare Pavillion
state: Kentucky
city: Louisville
country: United States
facility: Norton Medical Plaza II
state: Kentucky
city: Louisville
country: United States
facility: Norton Medical Plaza West
state: Kentucky
city: Louisville
country: United States
facility: Old Brownsboro Crossing
state: Kentucky
city: Baton Rouge
country: United States
facility: Baton Rouge General Medical Center
state: Louisiana
city: Bangor
country: United States
facility: Eastern Maine Medical Center
state: Maine
city: Baltimore
country: United States
facility: Mercy Medical Center
state: Maryland
city: Baltimore
country: United States
facility: Greater Baltimore Medical Center
state: Maryland
city: Baltimore
country: United States
facility: Franklin Square Hospital Center
state: Maryland
city: Baltimore
country: United States
facility: Harry & Jeannette Weinberg Cancer Institute
state: Maryland
city: Baltimore
country: United States
facility: Hematology-Oncology Associates
state: Maryland
city: Bethesda
country: United States
facility: Carolyn Hendricks, MD
state: Maryland
city: Bethesda
country: United States
facility: Suburban Hospital
state: Maryland
city: Chevy Chase
country: United States
facility: The Office of Frederik Smith
state: Maryland
city: Chevy Chase
country: United States
facility: Washington Oncology-Hematology Center, PC-Chevy Chase
state: Maryland
city: Rockville
country: United States
facility: Associates in Oncology/Hematology
state: Maryland
city: Salisbury
country: United States
facility: Peninsula Regional Oncology & Hematology
state: Maryland
city: Salisbury
country: United States
facility: Peninsula Regional Medical Center
state: Maryland
city: Silver Spring
country: United States
facility: Holy Cross Hospital
state: Maryland
city: Wheaton
country: United States
facility: Oncology Care Associates
state: Maryland
city: North Adams
country: United States
facility: Berkshire Hematology Oncology, P.C.-North Adams
state: Massachusetts
city: Pittsfield
country: United States
facility: Berkshire Hematology Oncology, P.C.
state: Massachusetts
city: Adrian
country: United States
facility: Bixby Medical Center
state: Michigan
city: Ann Arbor
country: United States
facility: CCOP, St. Joseph Mercy Hospital
state: Michigan
city: Battle Creek
country: United States
facility: Battle Creek Health System
state: Michigan
city: Bay City
country: United States
facility: Bay Regional Medical Center
state: Michigan
city: Bay City
country: United States
facility: Dr. Cook and Abramson - Bay City
state: Michigan
city: Brighton
country: United States
facility: St. Joseph Mercy Woodland Health Center
state: Michigan
city: Brownstown
country: United States
facility: Josephone Ford Cancer Center
state: Michigan
city: Dearborn
country: United States
facility: Henry Ford Medical Center-Fairlane
state: Michigan
city: Detroit
country: United States
facility: Henry Ford Hospital
state: Michigan
city: Escanaba
country: United States
facility: UP Hematology/Oncology Assoc.-Doctor's Park Family Physicians
state: Michigan
city: Flint
country: United States
facility: CCOP Hurley Medical Center
state: Michigan
city: Flint
country: United States
facility: Genesys Hurley
state: Michigan
city: Flint
country: United States
facility: Sing and Arora
state: Michigan
city: Grand Blanc
country: United States
facility: Genesys Regional Medical Center
state: Michigan
city: Grand Rapids
country: United States
facility: Grand Rapids Clinical Oncology Program
state: Michigan
city: Grand Rapids
country: United States
facility: Spectrum Health Hospitals
state: Michigan
city: Grand Rapids
country: United States
facility: St. Mary's Health Services
state: Michigan
city: Grosse Pointe Woods
country: United States
facility: CCOP, St. John Hospital and Medical Center
state: Michigan
city: Hancock
country: United States
facility: Portage Internal Medical Associates
state: Michigan
city: Iron Mountain
country: United States
facility: UP Hematology/Oncology Associates
state: Michigan
city: Ironwood
country: United States
facility: UP Hematology/Oncology Associates-Gogebic Range
state: Michigan
city: Kalamazoo
country: United States
facility: West Michigan Cancer Center
state: Michigan
city: Lambertville
country: United States
facility: Hematology/Oncology Associates of OH and MI, PC
state: Michigan
city: Lansing
country: United States
facility: CCOP, Sparrow Health System
state: Michigan
city: Lansing
country: United States
facility: Michigan State University - Breslin Cancer Center
state: Michigan
city: Lapeer
country: United States
facility: Hematology Oncology-Lapeer
state: Michigan
city: Lapeer
country: United States
facility: Lapeer Regional Hospital
state: Michigan
city: Laurium
country: United States
facility: Keewanaw Memorial Hospital
state: Michigan
city: Livonia
country: United States
facility: St. Mary Mercy Hospital - Livonia
state: Michigan
city: Marquette
country: United States
facility: Marquette General Hospital
state: Michigan
city: Marquette
country: United States
facility: Upper Peninsula Hematology/Oncology Associates
state: Michigan
city: Mount Clemens
country: United States
facility: Community Cancer Care Specialists-Mt. Clemens
state: Michigan
city: Mount Clemens
country: United States
facility: Mount Clemens Regional Medical Center
state: Michigan
city: Muskegon
country: United States
facility: Hackley Hospital
state: Michigan
city: Niles
country: United States
facility: Michiana Hematology-Oncology PC
state: Michigan
city: Royal Oak
country: United States
facility: CCOP, William Beaumont Hospital
state: Michigan
city: Saginaw
country: United States
facility: CCOP, St. Mary's Medical Center
state: Michigan
city: Saint Joseph
country: United States
facility: Lakeside Cancer Specialists, PLLC
state: Michigan
city: Saint Joseph
country: United States
facility: Michiana Hematology-Oncology, PC Lakeland
state: Michigan
city: Sault Sainte-Marie
country: United States
facility: Chippewa Medical Associates
state: Michigan
city: Shelby
country: United States
facility: Osteopathic Medical Oncology Hematology
state: Michigan
city: Traverse City
country: United States
facility: Munson Medical Center
state: Michigan
city: Warren
country: United States
facility: CCOP, St. John Macomb Hospital
state: Michigan
city: West Bloomfield
country: United States
facility: Henry Ford Medical Center-West Bloomfield
state: Michigan
city: Wyoming
country: United States
facility: Metro Health Hospital
state: Michigan
city: Burnsville
country: United States
facility: Minnesota Oncology Hematology-Burnsville
state: Minnesota
city: Burnsville
country: United States
facility: Park Nicollet Clinic
state: Minnesota
city: Coon Rapids
country: United States
facility: Hubert H. Humphrey Cancer Center - Coon Rapids
state: Minnesota
city: Edina
country: United States
facility: Minnesota Oncology Hematology-Edina
state: Minnesota
city: Edina
country: United States
facility: Fairview Southdale Medical Oncology Clinic
state: Minnesota
city: Fridley
country: United States
facility: Hubert H. Humphrey Cancer Center - Fridley
state: Minnesota
city: Maplewood
country: United States
facility: Minnesota Oncology Hematology PA - Maplewood
state: Minnesota
city: Minneapolis
country: United States
facility: Minnesota Oncology Hematology-Minneapolis
state: Minnesota
city: Robbinsdale
country: United States
facility: Hubert H. Humphrey Cancer Center-Robbinsdale
state: Minnesota
city: Saint Louis Park
country: United States
facility: Park Nicollet Health Services
state: Minnesota
city: Saint Paul
country: United States
facility: Minnesota Hematology Oncology-St. Paul
state: Minnesota
city: Waconia
country: United States
facility: Minnesota Oncology Hematology-Waconia
state: Minnesota
city: Woodbury
country: United States
facility: Minnesota Oncology Hematology
state: Minnesota
city: Southaven
country: United States
facility: University of Tennessee Cancer Institute
state: Mississippi
city: Columbia
country: United States
facility: University of Missouri-Ellis Fischel
state: Missouri
city: Joplin
country: United States
facility: Freeman Cancer Institute
state: Missouri
city: Joplin
country: United States
facility: St. John's Regional Health Center-Joplin
state: Missouri
city: Kansas City
country: United States
facility: Saint Luke's Hospital
state: Missouri
city: Kansas City
country: United States
facility: CCOP, Kansas City (Administrative Only)
state: Missouri
city: Springfield
country: United States
facility: St. John's Regional Health Center
state: Missouri
city: Springfield
country: United States
facility: Cox Health Systems
state: Missouri
city: Billings
country: United States
facility: Hematology Oncology Centers of the Northern Rockies
state: Montana
city: Henderson
country: United States
facility: Comprehensive Cancer Centers of Nevada (Siena)
state: Nevada
city: Las Vegas
country: United States
facility: University Medical Center of Southern Nevada
state: Nevada
city: Las Vegas
country: United States
facility: Cancer and Blood Specialists- Shadow Lane
state: Nevada
city: Las Vegas
country: United States
facility: Cancer Consultants
state: Nevada
city: Las Vegas
country: United States
facility: Nevada Cancer Institute
state: Nevada
city: Reno
country: United States
facility: Renown Regional Medical Center
state: Nevada
city: Reno
country: United States
facility: Alpine Hematology-Oncology
state: Nevada
city: Berkeley Heights
country: United States
facility: Summit Medical Group
state: New Jersey
city: Englewood
country: United States
facility: Drs. Forte, Schleider, Attas and Condemi, PA
state: New Jersey
city: Hamilton
country: United States
facility: Cancer Institute of New Jersey at Hamilton
state: New Jersey
city: Long Branch
country: United States
facility: Monmouth Medical Center
state: New Jersey
city: Morristown
country: United States
facility: Morristown Memorial Hospital
state: New Jersey
city: New Brunswick
country: United States
facility: Cancer Institute of New Jersey
state: New Jersey
city: Newark
country: United States
facility: University of Medicine and Dentistry of New Jersey
state: New Jersey
city: Newark
country: United States
facility: Newark Beth Israel Medical Center
state: New Jersey
city: Sparta
country: United States
facility: Sparta Cancer Treatment Center
state: New Jersey
city: Summit
country: United States
facility: Overlook Hospital
state: New Jersey
city: Albany
country: United States
facility: New York Oncology Hematology PC-Albany
state: New York
city: Albany
country: United States
facility: NY Oncology Hematology PC at Albany Medical Center
state: New York
city: Amsterdam
country: United States
facility: Amsterdam Community Cancer Program
state: New York
city: Canandaigua
country: United States
facility: Interlakes Oncology & Hematology, P.C.
state: New York
city: East Syracuse
country: United States
facility: Hematology Oncology Assaociates of CNY, CCOP
state: New York
city: Hudson
country: United States
facility: NY Oncology Hematology PC-Hudson Carvell Cancer Tx Prog.
state: New York
city: Latham
country: United States
facility: NY Oncology Hematology PC- Latham- Capital District Oncology Hematology
state: New York
city: New York
country: United States
facility: Beth Israel Medical Center
state: New York
city: New York
country: United States
facility: St. Luke's-Roosevelt Hospital Center
state: New York
city: Rexford
country: United States
facility: Riverview Cancer Care Medical Association
state: New York
city: Rome
country: United States
facility: Hematology Oncology Associates of CNY, CCOP
state: New York
city: Stony Brook
country: United States
facility: University Hospital and Medical Center - SUNY
state: New York
city: Stony Brook
country: United States
facility: University Hospital and Medical Center-SUNY
state: New York
city: Syracuse
country: United States
facility: Hematology Oncology Assoc. of CNY, CCOP (Comm. General Hospital Satellite Office)
state: New York
city: Troy
country: United States
facility: Troy Cancer Treatment Program
state: New York
city: Asheville
country: United States
facility: Cancer Care of Western North Carolina
state: North Carolina
city: Asheville
country: United States
facility: CCOP, Mission Hospitals, Inc.
state: North Carolina
city: Asheville
country: United States
facility: Cancer Center of NC at Asheville
state: North Carolina
city: Charlotte
country: United States
facility: Carolinas Hematology-Oncology Associates - Tyron St
state: North Carolina
city: Charlotte
country: United States
facility: Carolinas Medical Center - Blumenthal Cancer Center
state: North Carolina
city: Charlotte
country: United States
facility: CCOP Presbyterian Hospital
state: North Carolina
city: Charlotte
country: United States
facility: Mecklenburg Medical Group - Morehead Medical Dr
state: North Carolina
city: Charlotte
country: United States
facility: Mecklenburg Medical Group - Cameron Valley Pkwy
state: North Carolina
city: Charlotte
country: United States
facility: Carolinas Hematology Oncology Associates - Harris Blvd.
state: North Carolina
city: Charlotte
country: United States
facility: Carolinas Hematology-Oncology - John J. Delaney
state: North Carolina
city: Goldsboro
country: United States
facility: CCOP, Wayne Memorial Hospital
state: North Carolina
city: Greensboro
country: United States
facility: Moses Cone Regional Cancer Center
state: North Carolina
city: Hickory
country: United States
facility: Northwestern Carolina Oncology & Hematology, PA
state: North Carolina
city: Huntersville
country: United States
facility: Carolina BioOncology Institute
state: North Carolina
city: Akron
country: United States
facility: Akron City Hospital
state: Ohio
city: Akron
country: United States
facility: Akron General Medical Center
state: Ohio
city: Alliance
country: United States
facility: Alliance Cancer Center
state: Ohio
city: Canton
country: United States
facility: Aultman Hospital
state: Ohio
city: Canton
country: United States
facility: Tri County Hematology/Oncology
state: Ohio
city: Cincinnati
country: United States
facility: Kenwood Office
state: Ohio
city: Cincinnati
country: United States
facility: Oncology/Hematology Care Clinical Trials LLC
state: Ohio
city: Cincinnati
country: United States
facility: North Treatment Center - Blue Ash Medical Center
state: Ohio
city: Cincinnati
country: United States
facility: Oncology/Hematology Care Clinical Trials LLC, Cincinnati, OH Blue Ash Med. Cntr. (Administrative Only)
state: Ohio
city: Cincinnati
country: United States
facility: Oncology/Hematology Care Clinical Trials LLC
state: Ohio
city: Cleveland
country: United States
facility: Case Western Reserve/University Hospitals-Ireland Cancer Cntr.
state: Ohio
city: Dayton
country: United States
facility: Dayton Physicians-LLC-Hematology & Medical Oncology Division
state: Ohio
city: Fairfield
country: United States
facility: Healthplex
state: Ohio
city: Greenville
country: United States
facility: Dayton Physicians, LLC - Greenville
state: Ohio
city: Hamilton
country: United States
facility: Hamilton Office
state: Ohio
city: Kettering
country: United States
facility: Dayton Clinical Oncology Program-Kettering
state: Ohio
city: Kettering
country: United States
facility: Marian A. Llenado Lee, MD, Inc.
state: Ohio
city: Maumee
country: United States
facility: Northwest Ohio Oncology Center
state: Ohio
city: Orange Village
country: United States
facility: UHHS - Chagrin Highlands
state: Ohio
city: South Euclid
country: United States
facility: UHHS Green Road-Ireland Cancer Center
state: Ohio
city: Sylvania
country: United States
facility: Flower Memorial Hospital
state: Ohio
city: Toledo
country: United States
facility: Bayview Oncology Associates
state: Ohio
city: Toledo
country: United States
facility: Toledo Clinic
state: Ohio
city: Westlake
country: United States
facility: UHHS Westlake-Ireland Cancer Center
state: Ohio
city: Portland
country: United States
facility: Northwest Cancer Specialists-Portland
state: Oregon
city: Portland
country: United States
facility: Providence Portland Medical Center
state: Oregon
city: Portland
country: United States
facility: Adventist Medical Center
state: Oregon
city: Portland
country: United States
facility: Northwest Cancer Specialists-Adventist Office
state: Oregon
city: Portland
country: United States
facility: CCOP, Columbia River Oncology
state: Oregon
city: Portland
country: United States
facility: Providence Oncology and Hematology Care Clinic
state: Oregon
city: Portland
country: United States
facility: Providence St. Vincent Medical Center
state: Oregon
city: Allentown
country: United States
facility: Lehigh Valley Hospital
state: Pennsylvania
city: Danville
country: United States
facility: Geisinger Clinic
state: Pennsylvania
city: Donora
country: United States
facility: Hematology Oncology Associates of NE PA
state: Pennsylvania
city: Ephrata
country: United States
facility: Ephrata Cancer Center at Ephrata Community Hospital
state: Pennsylvania
city: Greensburg
country: United States
facility: UPMC Cancer Centers Arnold Palmer Pavilion-Mountainview
state: Pennsylvania
city: Greensburg
country: United States
facility: UPMC Cancer Centers Arnold Palmer-Oakbrook
state: Pennsylvania
city: Indiana
country: United States
facility: UPMC Cancer Centers-Indiana
state: Pennsylvania
city: Johnstown
country: United States
facility: UPMC Cancer Centers-John P. Murtha Cancer Center
state: Pennsylvania
city: McKeesport
country: United States
facility: UPMC Cancer Centers - McKeesport Hospital
state: Pennsylvania
city: Media
country: United States
facility: Riddle Memorial Hospital
state: Pennsylvania
city: Mount Pleasant
country: United States
facility: UPMC Cancer Centers Arnold Palmer-Mt. Pleasant
state: Pennsylvania
city: Philadelphia
country: United States
facility: Kimmel Cancer Center at Jefferson
state: Pennsylvania
city: Philadelphia
country: United States
facility: Cancer Center at Center One
state: Pennsylvania
city: Philadelphia
country: United States
facility: Albert Einstein Healthcare Network
state: Pennsylvania
city: Pittsburgh
country: United States
facility: Allegheny General Hospital/Allegheny-Singer Research Institute
state: Pennsylvania
city: Pittsburgh
country: United States
facility: NSABP Foundation, Inc
state: Pennsylvania
city: Pittsburgh
country: United States
facility: University of Pittsburgh
state: Pennsylvania
city: Pittsburgh
country: United States
facility: UPMC Cancer Centers - UPMC St. Margaret
state: Pennsylvania
city: Pittsburgh
country: United States
facility: Hillman Cancer Center
state: Pennsylvania
city: Pittsburgh
country: United States
facility: UPMC Cancer Centers - UPMC Passavant
state: Pennsylvania
city: Scranton
country: United States
facility: Mercy Hospital
state: Pennsylvania
city: Scranton
country: United States
facility: Scranton Hematology Oncology
state: Pennsylvania
city: Scranton
country: United States
facility: Hematology and Oncology Associates
state: Pennsylvania
city: State College
country: United States
facility: Mount Nittany Medical Center
state: Pennsylvania
city: Uniontown
country: United States
facility: UPMC Cancer Centers-Uniontown
state: Pennsylvania
city: Wexford
country: United States
facility: UPMC Cancer Centers - Wexford
state: Pennsylvania
city: York
country: United States
facility: York Hospital
state: Pennsylvania
city: Knoxville
country: United States
facility: Thompson Oncology Group-Blount
state: Tennessee
city: Knoxville
country: United States
facility: Thompson Cancer Survival Center-Dowell Springs
state: Tennessee
city: Knoxville
country: United States
facility: Thompson Cancer Survival Center
state: Tennessee
city: Knoxville
country: United States
facility: Thompson Oncology Group-West
state: Tennessee
city: Memphis
country: United States
facility: The West Clinic
state: Tennessee
city: Dallas
country: United States
facility: Texas Oncology- Sammons CC
state: Texas
city: Fort Worth
country: United States
facility: The Center for Cancer and Blood Disorders
state: Texas
city: Houston
country: United States
facility: Baylor College of Medicine
state: Texas
city: Houston
country: United States
facility: Ben Taub General Hospital
state: Texas
city: Lubbock
country: United States
facility: Covenant Health System dba Joe Arrington Cancer Research & Treatment Center
state: Texas
city: Plano
country: United States
facility: North Texas Regional Cancer Center
state: Texas
city: Murray
country: United States
facility: Intermountain Medical Center
state: Utah
city: Ogden
country: United States
facility: McKay-Dee Hospital
state: Utah
city: Provo
country: United States
facility: Utah Valley Regional Medical Center
state: Utah
city: Saint George
country: United States
facility: Dixie Medical Center
state: Utah
city: Salt Lake City
country: United States
facility: LDS Hospital
state: Utah
city: Richmond
country: United States
facility: VCU Massey Cancer Center at Stony Point
state: Virginia
city: Richmond
country: United States
facility: MBCCOP, Virginia Commonwealth University
state: Virginia
city: Bellevue
country: United States
facility: Overlake Internal Medicine
state: Washington
city: Spokane
country: United States
facility: Rockwood Cancer Treatment Center - Sinto Ave
state: Washington
city: Spokane
country: United States
facility: Rockwood Cancer Treatment Center
state: Washington
city: Vancouver
country: United States
facility: Southwest Washington Hospital
state: Washington
city: Vancouver
country: United States
facility: Northwest Cancer Specialists-136th Ave
state: Washington
city: Vancouver
country: United States
facility: Northwest Cancer Specialists-134th St.
state: Washington
city: Morgantown
country: United States
facility: West Virginia University Hospitals Inc.
state: West Virginia
city: Burlington
country: United States
facility: Oncology Alliance-Burlington
state: Wisconsin
city: Franklin
country: United States
facility: Oncology Alliance-Franklin
state: Wisconsin
city: Glendale
country: United States
facility: Oncology Alliance
state: Wisconsin
city: Green Bay
country: United States
facility: Aurora BayCare Medical Center
state: Wisconsin
city: Kenosha
country: United States
facility: Oncology Alliance-Kenosha South
state: Wisconsin
city: Kenosha
country: United States
facility: Oncology Alliance-Kenosha North
state: Wisconsin
city: Marshfield
country: United States
facility: CCOP, Marshfield Clinic
state: Wisconsin
city: Menomonee Falls
country: United States
facility: Oncology Alliance-Menomonee Falls
state: Wisconsin
city: Mequon
country: United States
facility: Oncology Alliance-Mequon
state: Wisconsin
city: Milwaukee
country: United States
facility: Oncology Alliance-South
state: Wisconsin
city: Racine
country: United States
facility: Oncology Alliance-Racine
state: Wisconsin
city: Waukesha
country: United States
facility: Oncology Alliance-Waukeska
state: Wisconsin
city: Weston
country: United States
facility: Marshfield Clinic Weston Center
state: Wisconsin
city: Derqui
country: Argentina
facility: Hospital Universitario Austral
state: Buenos Aires
city: La Plata
country: Argentina
facility: Breast Clinica de la mama
state: Buenos Aires
city: Rosario
country: Argentina
facility: Centro Oncologico Rosario (COR)
state: Sante Fe
city: Buenos Aires
country: Argentina
facility: Hospital Britanico de Buenos Aires
city: Buenos Aires
country: Argentina
facility: CEMIC
city: Campbelltown
country: Australia
facility: Macarthur Cancer Center
state: New South Wales
city: Kogarah
country: Australia
facility: St. George Hospital
state: New South Wales
city: Liverpool
country: Australia
facility: Cancer Therapy Center
state: New South Wales
city: St. Leonards
country: Australia
facility: North Shore Private Hospital
state: New South Wales
city: St. Leonards
country: Australia
facility: Royal North Shore Hospital
state: New South Wales
city: Wollongong
country: Australia
facility: Southern Medical Day Care
state: New South Wales
city: Herston
country: Australia
facility: Royal Brisbane & Women's Hospital
state: Queensland
city: South Brisbane
country: Australia
facility: Mater Adult Hospital
state: Queensland
city: Ashford
country: Australia
facility: Ashford Cancer Center
state: South Australia
city: Bedford
country: Australia
facility: Flinders Medical Centre
state: South Australia
city: Frankston
country: Australia
facility: Frankston Hospital
state: Victoria
city: Melbourne
country: Australia
facility: The Alfred Hospital
state: Victoria
city: Perth
country: Australia
facility: Mount Medical Center
state: Western Australia
city: Subiaco
country: Australia
facility: Berdat Family Comprehensive Cancer Centre
state: Western Australia
city: Graz
country: Austria
facility: Krankenhaus Barmherzige Brueder Graz, Medizinische Abteilung
city: Graz
country: Austria
facility: Universitatsfrauenklinik Graz
city: Graz
country: Austria
facility: Medizinische Universitat Graz - Onkologie
city: Innsbruck
country: Austria
facility: AI University Hospital Innsbruck
city: Kufstein
country: Austria
facility: Bezirkskrankenhaus Kufstein, Innere Medizin
city: Leoben
country: Austria
facility: Landeskrankenhaus Leoben, Abteilung fur Haemato-Onkologie
city: Linz
country: Austria
facility: Krankenhaus Barmherzige Schwestern Linz, Kooperative Studiengruppe, Chirurgie
city: Salzburg
country: Austria
facility: AI Universitätsklinikum der PMU Landeskliniken
city: Vienna
country: Austria
facility: AKH Vienna
city: Vienna
country: Austria
facility: Medizinische Universitaet Wien-Allgemeines Krankenhaus, Onkologie
city: Vienna
country: Austria
facility: Krankenhaus Hietzing, Gynaekologische Abteilung
city: Voecklabruck
country: Austria
facility: Landeskrankenhaus Voecklabruck, 2. Medizinische Abteilung
city: Wels
country: Austria
facility: Klinikum Wels-Grieskirchen, Kooperative Gruppe Wels/4. Medizinische Abteilung
city: Brasschaat
country: Belgium
facility: AZ Klina
city: Charleroi
country: Belgium
facility: C. H. Notre-Dame and Reine Fabiola
city: Ottignies
country: Belgium
facility: Clinique St Pierre
city: Wilrijk
country: Belgium
facility: Medical Institute St. Augustinus
city: Sarajevo
country: Bosnia and Herzegovina
facility: Clinical Centre University of Sarajevo
city: Goiania
country: Brazil
facility: Centro Goiano de oncologia
state: GO
city: Belo Horizonte
country: Brazil
facility: Lifecenter Sistema de Saude S/A
state: MG
city: Rio de Janeiro
country: Brazil
facility: Instituto Nacional de Cancer
state: RJ
city: Rio de Janeiro
country: Brazil
facility: Clinica Oncologistas Associados
state: RJ
city: Ijui
country: Brazil
facility: Assoiacao hospital de caridade de ijui
state: RS
city: Porto Alegre
country: Brazil
facility: Hospital Das Clinicas de Porto Alegre-HCPA
state: RS
city: Porto Alegre
country: Brazil
facility: Irmandade da Santa Casa de Misericoria de Porto Alegre Nucleo de Novos Tratamentos
state: RS
city: Porto Alegre
country: Brazil
facility: Clinica de Oncologia de Porto Alegre
state: RS
city: Jau
country: Brazil
facility: Fundacao Dr. Amaral Carvalho
state: SP
city: Piracicaba
country: Brazil
facility: Instituto de Oncologia Clinica de Piracicaba
state: SP
city: Santo Andre
country: Brazil
facility: Centro de Oncologia e Hematologia da Faculdade de Medicina do ABC
state: SP
city: Sao Paulo
country: Brazil
facility: Instituto do Cancer de Sao Paulo
state: SP
city: Sorocaba
country: Brazil
facility: Conjunto Hospitalar de Sorocaba
city: Plovdiv
country: Bulgaria
facility: District Oncology Dispensary Plovdiv
city: Sofia
country: Bulgaria
facility: MHAT "Tsaritsa Yoanna-ISUL" EOOD
city: Calgary
country: Canada
facility: Tom Baker Cancer Centre
state: Alberta
city: Edmonton
country: Canada
facility: Cross Cancer Institute, Dept of Medicine
state: Alberta
city: North Vancouver
country: Canada
facility: Lion's Gate Hospital
state: British Columbia
city: St. Johns
country: Canada
facility: Dr. H. Bliss Murphy Cancer Centre
state: Newfoundland and Labrador
city: Brampton
country: Canada
facility: William Osler Health Center
state: Ontario
city: Mississauga
country: Canada
facility: Credit Valley Hospital
state: Ontario
city: New Market
country: Canada
facility: Southlake Regional Health Centre
state: Ontario
city: Ottawa
country: Canada
facility: Ottawa Hospital Regional Cancer Centre
state: Ontario
city: Toronto
country: Canada
facility: St. Michaels Hospital
state: Ontario
city: Weston
country: Canada
facility: Humber River Regional Hospital
state: Ontario
city: Windsor
country: Canada
facility: Windsor Regional Cancer Centre
state: Ontario
city: Greenfield Park
country: Canada
facility: Hopital Charles LeMoyne
state: Quebec
city: Montreal
country: Canada
facility: Hopital Maisonneuve Rosemont
state: Quebec
city: Montreal
country: Canada
facility: Royal Victoria Hospital
state: Quebec
city: Montreal
country: Canada
facility: Montreal General Hospital
state: Quebec
city: Montreal
country: Canada
facility: Jewish General Hospital
state: Quebec
city: Montreal
country: Canada
facility: Hospital du Sacre-Coeur
state: Quebec
city: Montreal
country: Canada
facility: University of Montreal Hospital Group
state: Quebec
city: Quebec City
country: Canada
facility: Centre Hospitalier Affilie Universitaire De Quebec, Hospital du St-Sacrement
state: Quebec
city: Rancagua
country: Chile
facility: Hospital Regional Rancagua
state: VI Region
city: Beijing
country: China
facility: Chinese Academy of Medical Science
city: Beijing
country: China
facility: The Pla 307 Hospital
city: Beijing
country: China
facility: Chinese PLA General Hospital
city: Changchun
country: China
facility: Jilin Cancer Hospital
city: Chengdu
country: China
facility: West China Hospital, Sichuan University
city: Fuzhou
country: China
facility: Fuzhou General Hospital of Nanjing Military Area
city: Guangzhou
country: China
facility: Sun Yat-sen University Hospital
city: Hangzhou
country: China
facility: 1st Affiliated Hospital of Zhejiang University
city: Hangzhou
country: China
facility: Zhejiang Tumor Hospital
city: Tianjin
country: China
facility: Tianjin Cancer Hospital
city: Zagreb
country: Croatia
facility: University Hospital Zagreb
city: Praha 8
country: Czechia
facility: FN Na Bulovce
city: Cairo
country: Egypt
facility: National Cancer Institute
city: Tartu
country: Estonia
facility: Tartu University Hospital Clinic of Hematology and Oncology
city: Amiens
country: France
facility: CHU D'Amiens
city: Beauvais
country: France
facility: CH-Service Hemato-Oncologie
city: Bordeaux
country: France
facility: Clinique Bordeaux Nord Aquitaine
city: Brest
country: France
facility: CHU Morvan
city: Colmar
country: France
facility: Hopital Pasteur
city: Creteil
country: France
facility: Ch intercommunal de creteil
city: Dechy
country: France
facility: Centre Leonard de Vinci
city: Grenoble
country: France
facility: Institut Daniel Hollard
city: La Roche sur Yon Cedex
country: France
facility: CHD les Oudairies
city: Limoges
country: France
facility: Clinique Francois Chenieux
city: Limoges
country: France
facility: CHU Dupuytren
city: Marseille
country: France
facility: Hopital St. Joseph
city: Montpellier
country: France
facility: Centre Regional de Lutte contre le Cancer (CRLC) Val d'Aurelle
city: Nantes Cedex
country: France
facility: Centre Catherine de Sienne
city: Neuilly sur Seine
country: France
facility: Clinique Hartmann
city: Paris Cedex 12
country: France
facility: Hopital St. Antoine
city: Paris
country: France
facility: CHU Hotel Dieu
city: Rouen
country: France
facility: Clinique Saint Hilaire
city: Strasbourg
country: France
facility: Pole de cancerologie prive
city: Strasbourg
country: France
facility: CLCC Paul Strauss
city: Toulouse Cedex
country: France
facility: Institution Claudius Regaud
city: Toulous
country: France
facility: Polyclinique du Parc
city: Amberg
country: Germany
facility: Klinikum St. Marien Amberg
city: Bad Nauheim
country: Germany
facility: Hochwaldkrankenhaus
city: Böeblingen
country: Germany
facility: Klinikverbund Suedwest - Sindelfingen-Böeblingen Clinical Centre
city: Chemnitz
country: Germany
facility: Klinikum Chemnitz
city: Dresden
country: Germany
facility: Universitaetsklinikum Dresden
city: Duesseldorf
country: Germany
facility: Luisenkrankenhaus
city: Essen
country: Germany
facility: Universitaetsfrauenklinik
city: Frankfurt
country: Germany
facility: Zentrum fur Frauenheilkunde und Geburtshilfe
city: Fulda
country: Germany
facility: Medizinisches Versorgungszentrum Osthessen
city: Hameln
country: Germany
facility: Kreiskrankenhaus Hameln
city: Hanau
country: Germany
facility: Klinikum Stadt Hanau
city: Hannover
country: Germany
facility: Klinikum Hannover Nordstadt
city: Jena
country: Germany
facility: Universitat Frauenklinik Jena
city: Leer
country: Germany
facility: Onkologische schwerpunktpraxis
city: Lemgo
country: Germany
facility: Klinikum Lippe Lemgo
city: Lich
country: Germany
facility: Asklepios Kliniken Lich GmbH
city: Mainz
country: Germany
facility: Universitaetsklinikum Mainz
city: Mainz
country: Germany
facility: St. Vincenz u. Elisabeth Hospital
city: Munich
country: Germany
facility: RotKreuzKlinikum München GmbH
city: Munster
country: Germany
facility: Universitaetsklinikum Munster
city: Mönchengladbach
country: Germany
facility: Ev Krankenhaus Bethesda
city: Recklinghausen
country: Germany
facility: Praxis und Tagesklinik fuer Onkologie und
city: Rosenheim
country: Germany
facility: Klinikum Rosenheim
city: Stadhagen
country: Germany
facility: Klinikum Schaumburg
city: Stendal
country: Germany
facility: Johanniter Krankenhaus
city: Stuttgart
country: Germany
facility: Robert-Bosch-Krankenhaus
city: Traunstein
country: Germany
facility: Fachärzte fürlnnere Medizin, Hämatologie
city: Thessaloniki
country: Greece
facility: P.G. Hospital of Thessaloniki "Papageorgiou"
city: Hong Kong
country: Hong Kong
facility: Prince of Wales Hospital
city: Hong Kong
country: Hong Kong
facility: Queen Elizabeth Hospital
city: Budapest
country: Hungary
facility: Semmelweis Egyetem Clinic of Radiology
city: Debrecen
country: Hungary
facility: DEOEC Onkologiai Tanszek
city: Gyor
country: Hungary
facility: Petz Aladar Megyei Oktato
city: Kaposvar
country: Hungary
facility: Kaposi Mor oktato korhaz Onkologiai tanszek
city: Cork
country: Ireland
facility: Cork University Hospital
city: Dublin 4
country: Ireland
facility: St. Vincent's University Hospital
city: Dublin
country: Ireland
facility: Beaumont Hospital
city: Dublin
country: Ireland
facility: St. James's Hospital
city: Dublin
country: Ireland
facility: Adelaide and Meath National Childrens Hospital
city: Dublin
country: Ireland
facility: Institute for Cancer Research
city: Dublin
country: Ireland
facility: Mater Private Hospital
city: Galway
country: Ireland
facility: University College Hospital Galway
city: Limerick
country: Ireland
facility: Midwestern Regional Hospital
city: Sligo
country: Ireland
facility: Sligo General Hospital
city: Haifa
country: Israel
facility: The Lady Davis Carmel Medical Center/Lynn
city: Kfar
country: Israel
facility: Meir Medical Center
city: Rehovot
country: Israel
facility: Kaplan Medical Center
city: Tel Aviv
country: Israel
facility: Sourasky (Ichilov) Medical Center
city: Zefat
country: Israel
facility: Ziv Medical Center
city: Zerifin
country: Israel
facility: Assaf Harofeh Medical Center
city: Catania
country: Italy
facility: Humanitas Centro Catanese
city: Chieti
country: Italy
facility: (Azienda u.s.I. chieti) - Policinico Ospedaliero
city: Lecce
country: Italy
facility: Ospedale vito fazzi
city: Mirano
country: Italy
facility: Ospedale di Mirano
city: Napoli
country: Italy
facility: IRCCS - Instituto Nazionale per lo Studio e la Cura
city: Pavia
country: Italy
facility: Fondazione Salvatore Maugeri
city: Roma
country: Italy
facility: Ospedale S. Filippo Neri
city: Rome
country: Italy
facility: Regina Elena Cancer Institute
city: San-Giovanni
country: Italy
facility: Ospedale casa sollievo della sofferenza
city: Sassari
country: Italy
facility: Universita-istituto Clinica Medica
city: Taormina
country: Italy
facility: Asl n. 5 -Ospedale s. Vincenzo
city: Gyeonggi-do
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
city: Seoul
country: Korea, Republic of
facility: Severance Hospital
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
city: Seoul
country: Korea, Republic of
facility: Asan Medical Center
city: Riga
country: Latvia
facility: P. Stradina Clinical University Hospital
city: Monterrey
country: Mexico
facility: Opcion Oncologia
city: Arequipa
country: Peru
facility: Hospital Nacional Carlos Alberto Seguin
city: Lima
country: Peru
facility: Hospital Nacional Edgardo Rebagliati Martins
city: Cebu City
country: Philippines
facility: Cebu Doctors University Hospital
city: Bialystok
country: Poland
facility: Regional Oncology Center
city: Gliwice
country: Poland
facility: Centrum Onkologii Instytut im. M.
city: Olsztyn
country: Poland
facility: ZOZ MSWiA z Warminsko-Mazurskim Centrum
city: Olsztyn
country: Poland
facility: Olsztynski Osrodek Onkologiczny "Kopernik"
city: Rybnik
country: Poland
facility: Samodzielny Publiczny Zaklad Opieki
city: Warsaw
country: Poland
facility: Breast Cancer Clinic
city: Coimbra
country: Portugal
facility: HUC
city: Porto
country: Portugal
facility: IPO Francisco Gentil-Porto
city: Alba-Iulia
country: Romania
facility: County Hospital Alba-Iulia
city: Bucharest
country: Romania
facility: Institute of Oncology "AI.Trestioreanu"
city: Cluj-Napoca
country: Romania
facility: Institutul Oncologic "Prof. Dr. I. Chiricuta" Cluj-Napoca
city: Kazan
country: Russian Federation
facility: State Medical Institution "Republican Clinical Oncology Dispensary Ministry of Health of Republic Tatarstan"
city: Moscow
country: Russian Federation
facility: State Institution "Russian Oncological Research Center n.a. N.N. Blokhin of RAMS"
city: Saint Petersburg
country: Russian Federation
facility: Federal State Institution "Research Institute of Oncology n.a. N.N. Petrov Rosmedtechnologiy"
city: Saint Petersburg
country: Russian Federation
facility: Saint-Petersburg State Medical Institution "City Clinical Oncology Dispensary"
city: Belgrade
country: Serbia
facility: Clinical Hospital Center Bezanijska Kosa
city: Nis
country: Serbia
facility: Clinic of Oncology, Clinical Center nis
city: Maribor
country: Slovenia
facility: University Clinical Centre
city: Bloemfontein
country: South Africa
facility: Department of Oncotherapy National Hospital
city: Durban
country: South Africa
facility: Hopelands Cancer Centre
city: Johannesburg
country: South Africa
facility: Johannesburg Hospital
city: Las Palmas
country: Spain
facility: Hospital Universitario Insular de Gran Canaria
state: Canary Islands
city: Alcorcon
country: Spain
facility: Fundacion Hospitalaria de Alcorcon
city: Alicante
country: Spain
facility: Hospital General de Alicante
city: Badajoz
country: Spain
facility: Hospital Perpetuo Socorro
city: Badalona (Barcelona)
country: Spain
facility: Hospital Germans Trias l Pujol
city: Barbastro
country: Spain
facility: Hospital Comarcal de Barbastro
city: Barcelona
country: Spain
facility: Hospital Del Mar
city: Barcelona
country: Spain
facility: Hospital Santa Crue l San Pau
city: Barcelona
country: Spain
facility: Hospital Clinic i Provincial
city: Barcelona
country: Spain
facility: Consorci Sanitari de Terrassa
city: Barcelona
country: Spain
facility: Althaia Xarxa Assistencial de Manresa
city: Barcelona
country: Spain
facility: Hospital Espiritu Santo
city: Caceres
country: Spain
facility: Hospital De San Pedro de Alcantara
city: Elche
country: Spain
facility: Hospital Gral. De Elche
city: Gijon
country: Spain
facility: Hospital de Cabueñes, Oncologia Médica
city: Girona
country: Spain
facility: Instituto Catalan Oncologia de Girona
city: Jaen
country: Spain
facility: Complejo Hospitalario de Jaen
city: La Coruna
country: Spain
facility: Complejo Hospitalario Universitario A Coruna
city: La Coruña
country: Spain
facility: Centro Oncologico de Galicia
city: La Laguna
country: Spain
facility: Hospital Universitario de Canarias
city: Lugo
country: Spain
facility: Hospital Xera Calde
city: Madrid
country: Spain
facility: Hospital Universitario Gregorio Maranon
city: Madrid
country: Spain
facility: Hospital Ruber International
city: Madrid
country: Spain
facility: Fundacion Jimenez Diaz
city: Madrid
country: Spain
facility: Hospital Universitario San Carlos
city: Madrid
country: Spain
facility: Centro Integral de Oncologia "Clara Campal"
city: Malaga
country: Spain
facility: Hospital Clinico Virgen de la Victoria
city: Malaga
country: Spain
facility: Hospital Univesitario Carlos Haya
city: Ourense
country: Spain
facility: Hospital Santa Maria Nai Dr. Cabaleiro
city: Pontevedra
country: Spain
facility: Complejo Hospitalario de Pontevedra
city: Sabadell
country: Spain
facility: Hospital del Parc Tauli
city: Salamanca
country: Spain
facility: Hospital Universitario de Salamanca
city: San Sebastian
country: Spain
facility: Instituto Oncologico de Guipuzcoa
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen del Rocio
city: Torrevieja
country: Spain
facility: Hospital Torrevieja Salud, UTE
city: Valencia
country: Spain
facility: Hospital Clinico Universitario de Valencia
city: Zaragoza
country: Spain
facility: Hospital Clinico Universitario Lozano Blesa
city: Zaragoza
country: Spain
facility: Hospital U. Miguel Servet
city: Goteborg
country: Sweden
facility: Sahlgrenska University Hospital
city: Stockholm
country: Sweden
facility: Karolinska University Hospital
city: Changhua
country: Taiwan
facility: Changhua Christian Hospital
city: Kaohsiung
country: Taiwan
facility: Kaohsiung Medical University Chung
city: Tainan
country: Taiwan
facility: National Cheng Kung University
city: Taipei
country: Taiwan
facility: Sun Yat-Sen Cancer Center
city: Taipei
country: Taiwan
facility: Taipei Veterans General Hospital
city: Taoyuan
country: Taiwan
facility: Chang Gung Memorial Hospital
city: Patumwan
country: Thailand
facility: Chulalongkorn Hospital
state: Bangkok
city: Bangkok
country: Thailand
facility: National Cancer Institute
city: Songkhla
country: Thailand
facility: Songklanagarind Hospital
city: Bournemouth
country: United Kingdom
facility: Royal Bournemouth Hospital
city: Bristol
country: United Kingdom
facility: Bristol Hematology - Oncology Centre
city: Ipswich
country: United Kingdom
facility: Ipswich Hospital
city: Manchester
country: United Kingdom
facility: Christie Hospital NHS Trust
city: Nottingham
country: United Kingdom
facility: Nottingham City Hospital
city: Peterborough
country: United Kingdom
facility: Peterborough District Hospital
city: Truro
country: United Kingdom
facility: Sunrise Cancer Centre
Study officials:
affiliation: NSABP Foundation Inc
name: Norman Wolmark, MD
role: PRINCIPAL_INVESTIGATOR
References: