Clinical trial NCT05425407: Effects of Collagen Peptide Supplementation on Muscle and Tendon Damage and Function
Official title: A Randomized Double-blinded Placebo-controlled Study to Evaluate the Effect of Collagen Peptide (Collagen Peptan) Supplementation on Muscle and Tendon Damage, Repair, and Functional Capacity During Exercise Training Overload
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Exercise
Healthy Male Subjects
Keywords: Whey protein
Collagen peptide
Muscle and tendon overload training
Lead sponsor: KU Leuven
Sponsor class: OTHER
Collaborators: name: Rousselot BVBA
First posted: 2022-06-21
Enrollment: 22
Sex: MALE
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The aim of the study is to investigate the acute and short-term effects of collagen peptides (Collagen Peptan) on muscle and connective tissue during an eccentric overload training period. Currently, all studies investigating the effects of post-exercise collagen supplementation did this in the absence of whey proteins, which are part of the standard recommendations for post-exercise recovery. The investigators will therefore investigate whether the combined intake of whey proteins and collagen peptides ensures a better recovery of exercise performance and whether it can prevent or reduce symptoms of muscle and tendon overload during a three-week eccentric overload training period (n = 22).


Eligibility criteria: Inclusion Criteria:

* Sports participation, including general fitness training, between 2 and 5 hours max per week
* Body mass index between 18.5 and 25

Exclusion Criteria:

* Any kind of injury/pathology that is a contra-indication to perform high-intensity exercise - Intake of any medication or nutritional supplement that could impact muscle protein synthesis and/or exercise performance during the period of the study
* Intake of any whey protein, casein of branched-chain amino acid (BCAA) supplements from 1 month prior to the start of the study
* Blood donation within 3 months prior to the start of the study
* Smoking
* Current participation in another research trial
* Any other argument to believe that the subject is unlikely to successfully complete the full study

Primary outcomes:
measure: Change in countermovement jump performance
timeFrame: Pretest - 48 hours after the first training session (day 3 of training intervention) - Posttest (day 22 of training intervention)
measure: Change in maximal isometric knee-extension force of the right leg
timeFrame: Pretest - 48 hours after the first training session (day 3 of training intervention) - Posttest (day 22 of training intervention)
measure: Change in anteroposterior thickness of the right patellar tendon
timeFrame: Pretest - 48 hours after the first training session (day 3 of training intervention) - Posttest (day 22 of training intervention)
measure: Change in neovascularization of the right patellar tendon
timeFrame: Pretest - 48 hours after the first training session (day 3 of training intervention) - Posttest (day 22 of training intervention)
Secondary outcomes:
measure: Change in pain perception at the muscular level (VAS scale)
timeFrame: Training 1 (day 1 of training intervention) - Training 2 (day 3 of training intervention) - Training 8 (day 9 of training intervention) - Training 17 (day 19 of training intervention) - Posttest (day 22 of training intervention)
measure: Change in pain perception of the patellar tendon of the right leg (VISA-P)
timeFrame: Pretest - Training 1 (day 1 of training intervention) - Training 17 (day 21 of training intervention) - Posttest (day 22 of training intervention)
measure: Change in the blood concentration of creatine kinase
timeFrame: Pretest - Training 2 (day 3 of training intervention) - Posttest (day 22 of training intervention)
measure: Change in the blood concentration of Interleukin 6 (IL-6)
timeFrame: Pretest - Training 2 (day 3 of training intervention) - Posttest (day 22 of training intervention)
measure: Change in the blood concentration of N-terminal propeptide of type I procollagen (P1NP)
timeFrame: Pretest - Training 2 (day 3 of training intervention) - Posttest (day 22 of training intervention)
Other outcomes:
Locations:
city: Leuven
country: Belgium
facility: Exercise Physiology Research Group
state: Vlaams-Brabant
Study officials:
References: