louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01791283: Real-time Comparison of Left Ventricular Strokevolume Measurement by Four Different Methods
Official title: Real-time Comparison of Left Ventricular Strokevolume Measurement by Four Different Methods
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Difference in Measured Results Using Four Different Strokevolume Measurements Simultaneously.
Keywords: Left ventricular stroke volume
Arterial waveform analysis
Esofageal doppler
Ultrasound
Cardiac magnetic Imaging
Limits of agreement
Lead sponsor: University Hospital, Linkoeping
Sponsor class: OTHER
First posted: 2013-02-13
Enrollment: 20
Sex: ALL
Minimum age (years): 20
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Healthy volounteers

Brief summary: Real-time comparison of three different bedside strokevolumemeasurements (arterial waveform analysis, eosofageal doppler and 2D transthoracal ultrasound) validated against cardiac magnetic resonance imaging (CMRI)

Detailed description: 20 healthy volounteers between age of 20-40 years, no previous medical history undergo simoultaneous left ventrikular strokevolume measurements using three different methods at rest. After datasampling and without moving, the subject then undergo Cardiac Magnetic Resonance Imaging with 2D-throughplane and cine tecnology for validation of volume measurements. The data is then analyzed using Bland-Altman calculation.

Eligibility criteria: Inclusion Criteria:Healthy volounteers age 20-40, BMI \< 30, weight \< 100 kg, no medications, sinus rythm on ECG, no contra-indications for MRI, ability to give written informed consent.

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Exclusion Criteria:

* Heart and/or vascular disease such as angina pectoris, arrythmias, claudicatio intermittens e g.
* Diseases in gastrointestinal tract or nose.
* Coagulopathies
* Pregnancy
* Allergys for local anaesthetics
* Claustrofobia

Primary outcomes:
measure: Limits of agreement (LOA) is less than 30% using CMRI as validation for each individual measurement of left ventricular stroke volume.
timeFrame: Study period (1 month)
Secondary outcomes:
Other outcomes:
Locations:
city: Linkoping
country: Sweden
facility: Departement for intensive care medicine, Universitetssjukhuset
Study officials:
affiliation: Intensivvardskliniken, Linkoping University Hospital
name: Goran Liffner, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06910397: The Effect of Probiotics on Gums Health and Bad Breath
Official title: Evaluating The Effect of Probiotics on Oral Health Status and Its Influence on The Gingival Disease and Halitosis in Iraq
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Gingivitis
Keywords: probiotics and gingival health
Lead sponsor: Al-Mustansiriyah University
Sponsor class: OTHER
First posted: 2025-04-04
Enrollment: 90
Sex: ALL
Minimum age (years): 17
Maximum age (years): 25
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: the study is about using healthy bacteria to improve the overall gingival and overall health and prevent or decrease the bad odor of the mouth caused by bad bacteria

Detailed description: The goal of this study is to verify the effect of Probiotics on oral Health Status and eliminate the gingival disease and Halitosis by measuring the levels of salivary biomarkers (cytokine IL-1b and proteases Matrix metalloproteinase (MMP-8) in saliva) and level of volatile sulfur compounds (VSCs) and their effects on improving gingival diseases clinical parameters in person age of (17-25) years old. The participants are randomly divided into two parallel groups (A, B). Group A will take probiotics and group B will take placebo for 28 days. The levels of IL-1b, MMP-8 in saliva, and VSCs measurement will be recorded respectively in different intervals of zero time and repeated on 14 days and 28 days.

Statistical analysis will be done then comparative between two groups

Eligibility criteria: The Inclusion criteria

* Subjects (male and female) between the age range 17-25 years old.
* Subjects with mouth breathing habit.
* Subjects with orthodontic and prosthodontic appliance
* Race from Iraq.
* Subjects having a dentition with ≥20 evaluable teeth (minimum of five teeth per quadrant).

The Exclusion criteria

* History of chronic disease.
* History of systemic disease.
* Patients with autoimmune diseases.
* Patients under antibiotic treatment.
* Pregnant, lactating females.
* History of undergoing nonsurgical and surgical periodontal therapy in the last 6 months.

Primary outcomes:
measure: oral health measures for 90 participant of both group
timeFrame: four weeks(0day,14 day,28 day)
measure: Halitosis (90 participant of both group)
timeFrame: four weeks(0 day,14 day, 28 day)
Secondary outcomes:
measure: The salivary biomarkers (90 participant of both group)
timeFrame: four weeks (0 day,14 day ,28 day)
Other outcomes:
Locations:
city: Bagdad
country: Iraq
facility: AL- Mustansiriyah University College of Dentistry
Study officials:
name: BAYDAA Y Alani, MSc student
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00366197: Prediction of Weaning Outcomes by Using Rate of Change of Rapid Shallow Breathing Index
Official title: Prediction of Weaning Outcomes by Using Rate of Change of Rapid Shallow Breathing Index
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Rapid Shallow Breathing
Keywords: Rapid Shallow Breathing Index
Mechanical Ventilation
Lead sponsor: Atlantic Health System
Sponsor class: OTHER
First posted: 2006-08-21
Enrollment: 100
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Male and Female

Brief summary: This trial examines weaning outcomes using the rapid shallow breathing index rate.

Detailed description: We hypothesize that the trend of the Rapid Shallow Breathing Index or RSBI rate, is a better predictor of weaning outcome than the RSBI as a single value during the weaning trial. patients are recruited during a weaning trial on t-piece and the RSBI during what the RSBI is measured periodically. The outcome is ventilatory status at 24 hours after the weaning trial.

Eligibility criteria: Inclusion Criteria:

* Requires need of mechanical ventilation for \> 48 hours with a tube size no smaller than 7.5

Exclusion Criteria:

* Healthy volunteers

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Morristown
country: United States
facility: Morristown Memorial Hospital
state: New Jersey
Study officials:
affiliation: Atlantic Health System
name: Stanley Fiel, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Atlantic Health System
name: Harris Rana, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Atlantic Health System
name: Salvatore Ruggiero, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Atlantic Health System
name: Erwin Oei, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05880797: Multidimensional and Multimodal Profiling of Oropharyngeal Carcinoma
Official title: Multidimensional and Multimodal Profiling of Oropharyngeal Carcinoma
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Oropharyngeal Carcinoma
Human Papilloma Virus
Lead sponsor: Stanford University
Sponsor class: OTHER
First posted: 2023-05-30
Enrollment: 1000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Participants with known or suspected oropharyngeal carcinoma. All patients with OPC getting surgery at Stanford are invited to participate in the study.

Brief summary: The purpose of this study is to better understand the natural history of oropharyngeal carcinoma (OPC), with or without an association with the human papilloma virus (HPV). For this study, the investigators plan to collect blood from OPC patients prior to treatment and at six subsequent time points.


Eligibility criteria: Inclusion Criteria:

* Patients diagnosed with oropharyngeal carcinoma or patients with cancer of the unknown primary that is HPV associated, or possibly deemed to be originating from the oropharynx.

Exclusion Criteria:

* Not willing to sign consent

Primary outcomes:
measure: Sample collection
timeFrame: prior to start of treatment
measure: Sample collection
timeFrame: up to 36 months post-op
Secondary outcomes:
measure: tumor sample
timeFrame: Day 1
Other outcomes:
Locations:
city: Palo Alto
country: United States
facility: Stanford University
state: California
Study officials:
affiliation: Stanford University
name: Chris Holsinger, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00862797: Pressure Course in the Tube Cuff During Swallowing
Official title: Pressure Course in the Tube Cuff During Swallowing
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Anesthesia
Intensive Care
Keywords: endotracheal tube
swallowing
aspiration
cuff pressure
pneumonia
Lead sponsor: University Hospital Freiburg
Sponsor class: OTHER
First posted: 2009-03-17
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients recovering from general anaesthesia or intensive care patients both intubated with cuffed endotracheal tubes

Brief summary: Leakage of fluid from the subglottic space to the lungs occurs along the longitudinal folds within the wall of endotracheal tube (ETT) cuffs. In this project the researchers investigate the possible effect of swallowing on the pressure course in the ETT cuff.


Eligibility criteria: Inclusion Criteria:

* age over 18 years
* general anaesthesia or intensive care medicine treatment

Exclusion Criteria:

* refusal of written informed consent

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Freiburg
country: Germany
facility: University Medical Center Freiburg
Study officials:
affiliation: University Medical Center Freiburg
name: Daniel Steinmann, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04194177: Evaluation of Thoracic Impedance Tomography During Robotic Surgery
Official title: Evaluation of Two Types of Mechanical Ventilation During Robotic Surgery With the Thoracic Impedance Tomography
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Atelectasis
Lead sponsor: Federico II University
Sponsor class: OTHER
First posted: 2019-12-11
Enrollment: 40
Sex: MALE
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: the evaluation of distribution of mechanical ventilation during robotic surgery


Eligibility criteria: Inclusion Criteria:

* age\>18
* informed consent
* robotic surgery

Exclusion Criteria:

* age\<18
* no consent for the study

Primary outcomes:
measure: distribution of tidal volume
timeFrame: at the end of surgery
Secondary outcomes:
measure: driving pressure
timeFrame: at the end of surgery
Other outcomes:
Locations:
city: Naples
country: Italy
facility: University of Naples Federico II department of Anesthesia and Critical Care
Study officials:
References:
Clinical trial NCT04941677: Exploring Hand Function in People With Schizophrenia Based on Perspective of Sensorimotor Control
Official title: Exploration of the Relationships Between Vocational Performances Ans Sensorimotor Factors of Hands in Schizophrenia
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Schizophrenia
Keywords: hand function
sensorimotor
motor control theory
Lead sponsor: National Cheng-Kung University Hospital
Sponsor class: OTHER
First posted: 2021-06-28
Enrollment: 37
Sex: ALL
Minimum age (years): 20
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Participants with schizophrenia will be recruited from the Department of Internal Medicine in National Cheng Kung University Hospital

Brief summary: The study aims to explore the hand function in people with schizophrenia in the chronic stage.


Eligibility criteria: Inclusion Criteria:

* Age between 20-65 years old
* Diagnosis with schizophrenia or schizoaffective disorder by psychiatrists according to DSM5.
* Remaining the same antipsychotics and the symptom was stable for at least one month before the study.
* Be able to follow comments and have sufficient cognitive ability assessed by Mini-Mental State Examination score \>24

Exclusion Criteria:

* Substance abuse or other medical conditions that may affect movements.
* Using other non-antipsychotics that will affect movements in the same period.

Primary outcomes:
measure: Semmes Weinstein Monofilaments
timeFrame: baseline
measure: Pinch-holding-up-activity test
timeFrame: baseline
measure: Manual Tactile Test
timeFrame: baseline
measure: Purdue pegboard test
timeFrame: baseline
measure: The Valpar 8 simulates assembly work assessment
timeFrame: baseline
Secondary outcomes:
measure: Self-reported version of the graphic Personal and Social Performance (SRG-PSP)
timeFrame: baseline
Other outcomes:
Locations:
city: Tainan
country: Taiwan
facility: National Cheng-Kung University
Study officials:
References:
Clinical trial NCT03818477: Environmental Surveillance (ES) for Polio and AMR Using the TaqMan Array Card
Official title: Evaluation of TaqMan Array Card for Environmental Surveillance of Polio Virus and Antimicrobial Resistance Genes
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Polio
Lead sponsor: University of Virginia
Sponsor class: OTHER
Collaborators: name: Bill and Melinda Gates Foundation
name: International Centre for Diarrhoeal Disease Research, Bangladesh
First posted: 2019-01-28
Enrollment: 8500
Sex: ALL
Maximum age (years): 4
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: ECOLOGIC_OR_COMMUNITY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The investigators will conduct a Supplementary Immunization Activity (SIA) using bivalent oral polio vaccine (bOPV) and administer bOPV to at least 70% of all children under the age of 5 in the participating wards in the urban slums of Mirpur, Dhaka

Brief summary: This study will be used to develop a tool to streamline poliovirus environmental surveillance for the polio endgame and to provide a tool for detecting polio in places where there is no capacity to carry out the gold standard culture-based detection.

Detailed description: This environmental surveillance tool will also include antimicrobial resistance (AMR) genes to describe resistome profile in environmental samples and to better inform us of the potential risks of exposure to these environments

Eligibility criteria: Inclusion Criteria

* birth-4 years of age
* reside in selected urban slums of Mirpur Dhaka, Bangladesh
* receiving bOPV immunization

Exclusion Criteria:

* parent unwilling to consent

Primary outcomes:
measure: Polymerase Chain Reaction (PCR) detection of poliovirus, enteric pathogens and antimicrobial resistance genes from environmental samples
timeFrame: through study completion, an average of 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Dhaka
country: Bangladesh
facility: International Centre for Diarrhoeal Disease Research
Study officials:
affiliation: University of Virginia
name: Mami Taniuchi
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03007277: Evaluation of the French Maternal and Child Protection Services From 11 French Territories That Have Received Common Intervention Guidelines
Official title: Evaluation de l'Intervention Des Services de Protection Maternelle et Infantile de 11 départements français Ayant bénéficié d'un référentiel Commun d'Intervention à Domicile (Projet Panjo : Promotion de la Santé et de l'Attachement Des Nouveau-nés et de Leurs Jeunes Parents : un Outil de Renforcement Des Services de PMI)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Parent-Child Relations
Maltreatment by Parent
Parents
Mental Health Wellness 1
Lead sponsor: L'Agence des Nouvelles Interventions Sociales et de Santé
Sponsor class: OTHER
Collaborators: name: Institut national de prevention et d'education pour la sante
name: Université du Québec a Montréal
First posted: 2017-01-02
Enrollment: 447
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The PANJO study aims to evaluate, within the French public health services, the impact of a home visitors training on parent-child attachment, families outcomes, use of services and child maltreatment indicators.

Detailed description: In translation

Eligibility criteria: Inclusion Criteria:

* Nulliparous
* Pregnant \<32 weeks of amenorrhea
* Answers yes to the following question: "do you feel alone facing the upcoming changes related to your child"

Exclusion Criteria:

* Intends to move outside the area in which she can receive the intervention
* Sees a psychologist or psychiatrist at least once per week
* Refuses to participate

Primary outcomes:
measure: Parental self-efficacy
timeFrame: Child 6th month
measure: Parental Stress Inventory
timeFrame: Child 6th month
measure: Service Use
timeFrame: Child 6th month
measure: Accidents
timeFrame: Child 6th month
measure: Child Maltreatment
timeFrame: Child 6th month
Secondary outcomes:
measure: Pacotis-Parental Impact
timeFrame: Child 6th and 12th month
measure: Parental Stress Inventory - Parental Distress
timeFrame: Child 6th and 12th month
measure: Knowledge of Infant Development Inventory (KIDI questionnaire)
timeFrame: Child 6th and 12th month
measure: Edinburgh Postnatal Depression Scale
timeFrame: Child 6th and 12th month
Other outcomes:
Locations:
city: Saint Denis
country: France
facility: Agence Nationale de Santé Publique
Study officials:
affiliation: L'Agence des Nouvelles Interventions Sociales et de Santé
name: Thomas Saïas, Ph.D.
role: PRINCIPAL_INVESTIGATOR
References:
citation: Saïas, T, Delawarde, C, Colson, S, Planche, M, Vallée, V, Du Roscoät, E, Bonnard, A, Bodard, J, Dugravier, R. De l'expérimentation scientifique à l'implantation dans les services publics : le projet Panjo. Revue Francophone Internationale de Recherche Infirmière, 2 : 232-241, 2016.
Clinical trial NCT06385977: Risk Factors for Chronic Prostatitis Patients in Northwest China
Official title: Risk Factors for Chronic Prostatitis/Chronic Pelvic Pain Syndrome Patients in Northwest China
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Chronic Prostatitis With Chronic Pelvic Pain Syndrome
Lead sponsor: Shaanxi Provincial People's Hospital
Sponsor class: OTHER
First posted: 2024-04-26
Enrollment: 400
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All patients are from Urology Clinic, while all the controls are recruited from the physical examination center of our hospital.

Brief summary: The goal of this observational study is to learn about the risk factors of lifestyle, medication and sexual habits in adult chronic prostatitis / chronic pelvic pain syndrome patients. The main questions it aims to answer are:

* Is lifestyle, medication, and sexual habits related to chronic prostatitis / chronic pelvic pain syndrome
* Is there any medication available to protect men from chronic prostatitis / chronic pelvic pain syndrome.

Participants will:

* Independently receive a survey questionnaire on lifestyle, medication, and sexual habits.
* Symptomatic individuals will undergo additional prostate fluid examination for diagnosis.

Researchers will compare healthy adult males to see if there are differences on lifestyle, medication and sexual habits between the two groups.

Detailed description: All participants were asked to fill out a questionnaire which was modified based on Zhang Ran's research. The questionnaire contained the following parts: patient's general situation, dietary habits, disease status, medication, lifestyle, sexual habits and NIH-CPSI index (National Institutes of Health Chronic Prostatitis Symptom Index). Furthermore, the patients underwent digital rectal examination, expressed prostatic secretion microscopy and microbial culture, urinalysis, urine microbial culture and transrectal ultrasonography.

Eligibility criteria: Inclusion Criteria:

* Discomfort or pain in the pelvic region or perineum;
* Symptoms lasting for at least 3 months;
* NIH-CPSI pain score of ≥ 4;
* Controls are volunteers who do not present any prostatitis-related symptoms.

Exclusion Criteria:

* Prostate cancer;
* Benign prostatic hyperplasia with a post-void residual urine volume of \>50 ml;
* Acute urinary tract infection.

Primary outcomes:
measure: Odds Ratio
timeFrame: baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Xi'an
country: China
facility: Shaanxi Provincial People's Hospital
state: Shaanxi
Study officials:
affiliation: Shaanxi Provincial People's Hospital
name: Chun Du, Professor
role: STUDY_DIRECTOR
References:
Clinical trial NCT05240677: Endoscopy in CKD With Iron Deficiency Anemia
Official title: Value of Esophageogastroduodenscopy in Assessment of Chronic Kidney Disease Patients With Iron Deficiency Anemia Without Gastrointestinal Symptoms
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Chronic Kidney Diseases
Iron-Deficiency Anemia
Lead sponsor: Zagazig University
Sponsor class: OTHER_GOV
First posted: 2022-02-15
Enrollment: 81
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: DIAGNOSTIC

Brief summary: Iron deficiency anemia is very common in CKD patients. Data about gastrointestinal lesions in Arab patients are insufficient.

Detailed description: Iron deficiency anemia without gastrointestinal symptoms needs to be assessed in patients with chronic kidney disease.

Eligibility criteria: * Patients with eGFR is less than 60 ml/m/1.73 m2.
* Patients with iron deficiency anemia.
* Absence of gastrointestinal symptoms.

Primary outcomes:
measure: Rate of upper gastrointestinal endoscopic findings In chronic kidney disease patients with iron deficiency anemia
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Zagazig
country: Egypt
facility: Zagazig university
Study officials:
References: