Clinical trial NCT02129387: EEG & Behavioral Predictors of Changes in Smoking Trajectories in Young Light Smokers
Official title: EEG & Behavioral Predictors of Changes in Smoking Trajectories in Young Light Smokers
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Nicotine Dependence
Keywords: Nicotine
Smoking Progression
EEG
Young adults
Light smokers
rs1051730 genotype
Lead sponsor: Southern Illinois University Carbondale
Sponsor class: OTHER
First posted: 2014-05-02
Enrollment: 115
Sex: ALL
Minimum age (years): 18
Maximum age (years): 25
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Community sample of young light smokers

Brief summary: The purpose of the proposal is to identify new predictors of smoking progression in young light smokers (YLS: 18-25 years \& cpd \< 5) using an 18-month longitudinal design and to relate these predictors of progression to the genetic profile most highly associated with smoking progression. A number of novel predictors will be assessed in 128 YLS. Predictors will include individual differences (IDs) in EEG, reward sensitivity, attentional performance, and mood during abstinence and in response to standardized and to self-selected acute nicotine doses (ANIC), as well as genetically influenced affective traits, and smoking history. The associations of a compelling genetic functional variant polymorphism, rs16969968, in the alpha5 nicotinic receptor subunit will also be related to smoking progression and the novel predictors. The study is expected to provide insights into IDs in mechanisms and predictors that contribute to smoking trajectories in YLS and thereby lead to targeted pharmacotherapy and behavioral interventions for at-risk YLS.

Detailed description: The purpose of the proposal is to identify new biobehavioral endophenotypes that predict smoking progression in young light smokers (YLS: 18-25 years \& cpd \< 5) using an 18-month longitudinal design and to relate these endophenotypes and progression to the genetic profile most highly associated with smoking progression. A number of novel predictors will be assessed in 128 YLS. Predictors will include individual differences (IDs) in EEG, reward sensitivity, attentional performance, and mood during abstinence and in response to standardized and to self-selected acute nicotine doses (ANIC), as well as genetically influenced affective traits, and smoking history. The associations of a compelling genetic functional variant polymorphism, rs16969968, in the alpha5 nicotinic receptor subunit will also be related to smoking progression and the novel predictors. The study is expected to provide insights into IDs in mechanisms and endophenotypes that contribute to smoking trajectories in YLS and thereby lead to targeted pharmacotherapy and behavioral interventions for at-risk YLS.

Eligibility criteria: Inclusion Criteria:

* smokers of 3 to 30 cigarettes per week for past 6 months

Exclusion Criteria:

* Smoking fewer than 3 or more than 30 tobacco cigarettes per week
* Never smoked more than 30 cigarettes per week
* Psychoactive drug use other than caffeine or occasional marijuana
* Current serious psychiatric diagnosis (e.g., major depressive disorder)
* Recent drug dependence
* Left-handed
* Color blind

Primary outcomes:
measure: change in smoking and salivary cotinine concentration
timeFrame: 18 months
Secondary outcomes:
measure: reason for change in smoke rate
timeFrame: 18 months after initial assessment
Other outcomes:
Locations:
city: Carbondale
country: United States
facility: Southern Illinois University Carbondale Department of Psychology
state: Illinois
Study officials:
affiliation: Southern Illinois University Carbondale
name: David G Gilbert, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Whitton AE, Rabinovich NE, Lindt JD, Pergadia ML, Pizzagalli DA, Gilbert DG. Genetic and Depressive Traits Moderate the Reward-Enhancing Effects of Acute Nicotine in Young Light Smokers. Nicotine Tob Res. 2021 Aug 29;23(10):1779-1786. doi: 10.1093/ntr/ntab072.