Clinical trial NCT04638205: The Life Paths That Lead Teenagers to Attempted Suicide:Trajectories of Proximal Adversity
Official title: The Life Paths That Lead Teenagers to Attempted Suicide: Trajectories of Proximal Adversity
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Suicide, Attempted
Keywords: Suicide attempt
adolescence
adverse life event
developmental model
trajectories
Lead sponsor: University Hospital, Lille
Sponsor class: OTHER
First posted: 2020-11-20
Enrollment: 120
Sex: ALL
Minimum age (years): 15
Maximum age (years): 24
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patient recruitment will be supported by the VigilanS program. VigilanS is a suicide recurrence prevention device implemented in all establishments in the Hauts-de-France region that receive patients who have attempted suicide (www.dispositifvigilans.org).

Brief summary: Suicidal behaviors seriously alter the vital and functional prognosis of adolescents. Although the literature has lighted out a considerable number of risk factors for suicide attempts in youth, theoretical models - among which bio-psycho-social models - still lack empirical evidence. More specifically, the way adverse life events dynamically interact together and with the individual's diathesis to precipitate suicidal attempts remains unclear. Studies of life trajectories have opened an alternative approach to traditional linear epidemiological analysis to capture such a complex process. To date, adverse trajectories approaches never have been applied to the period immediately preceding the occurrence of the suicidal gesture (proximal adverse trajectories).


Eligibility criteria: Inclusion Criteria:

* Inclusion criteria for cases
* Youth aged 15-24 inclusive
* Who stayed at the hospital or in the emergency room for less than 15 days after a first suicide attempt
* Who were discharged less than 15 days ago
* Who gave their informed consent for majors, or whose parents gave their informed consent for minors Inclusion criteria for controls
* Youth aged 15-24 inclusive
* Who have never experienced any suicidal ideation or suicide attempt
* Who gave their informed consent for majors, or whose parents gave their informed consent for minors Inclusion criteria for informants
* Close relatives of the participant
* Who are major
* Who lived in the same household as the participant or have interacted with him/her for more than half the weeks of the year preceding the index suicide attempt

Exclusion Criteria:

* No consent or consent withdrawal for majors and/or their parents for minors
* Neurological or psychiatric condition altering the capacity to understand

Primary outcomes:
measure: Growth parameters of the patterns of proximal adverse trajectories in adolescents who attempted suicide, as compared to non-suicidal adolescents
timeFrame: 1 year
Secondary outcomes:
measure: Statistical tests comparing the sociodemographic, vulnerabily and psychopathological indicators between the sub-group of adolescents identified from the mixture model.
timeFrame: 1 year
measure: Growth parameters of the patterns of evolution of psychological pain
timeFrame: 1 year
measure: Growth parameters of the patterns of evolution of suicidal ideation intensity
timeFrame: 1 year
Other outcomes:
Locations:
city: Lille
country: France
facility: Hop Fontan - Chu Lille
Study officials:
affiliation: University Hospital, Lille
name: Charles-Edouard Notredame, MD
role: PRINCIPAL_INVESTIGATOR
References: