louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06648551: Diagnostic Performance of Controlling Nutritional Status as a Nutritional Screening Tool in Patients With Inflammatory Bowel Disease
Official title: Diagnostic Performance of CONUT as a Nutritional Screening Tool in Patients With Inflammatory Bowel Disease
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Inflammatory Bowel Disease 5
Lead sponsor: Hospital General de Mexico
Sponsor class: OTHER_GOV
First posted: 2024-10-18
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Ulcerative Colitis patients

Brief summary: The objective of this observational study is to determine the diagnostic performance of CONUT as a nutritional screening tool in patients with Inflammatory Bowel Disease. The main questions to be answered are:

What is the sensitivity and specificity of CONUT as a nutritional screening tool in patients with Inflammatory Bowel Disease?

The participants will:

Undergo body composition analysis and a medical history review to understand the characteristics of their current condition, apply the GLIM criteria, and conduct their nutritional assessment.


Eligibility criteria: Inclusion Criteria:

* Age 18 years and older
* Gender unspecified
* Histologically confirmed Ulcerative Colitis
* Diagnosis confirmed by a specialist physician

Exclusion Criteria:

* Patients with any amputation or prosthesis
* Patients with a pacemaker
* Patients with any neoplasm
* Pregnancy or lactation
* With comorbidities such as diabetes, hypertension, heart failure, thyroid problems

Primary outcomes:
measure: Diagnostic test
timeFrame: one year
Secondary outcomes:
Other outcomes:
Locations:
city: Mexico City
country: Mexico
facility: Nallely Hernandez Bueno
state: Cuauhtemoc
Study officials:
References:
Clinical trial NCT00851851: New Non-invasive Methods for Real-time Monitoring of Organ Function.
Official title: New Non-invasive Methods for Real-time Monitoring of Organ Function.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Acute Renal Failure
Chronic Renal Failure
Keywords: Surgical patients
Lead sponsor: Washington University School of Medicine
Sponsor class: OTHER
First posted: 2009-02-26
Enrollment: 641
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Surgical patients.

Brief summary: Measuring novel proteins in the urine of surgical patients that can be used to diagnose impending acute or chronic renal failure.


Eligibility criteria: Inclusion Criteria:

* Patients \> 18 years of age

Exclusion Criteria:

* Patients at end stage renal disease
* Patients dependent on dialysis at time of surgery

Primary outcomes:
measure: To identify acute, chronic or lack of renal failure
timeFrame: Pre-op, intraoperative, post operatively (1-6 months)
Secondary outcomes:
Other outcomes:
Locations:
city: St. Louis
country: United States
facility: Barnes Jewish Hospital
state: Missouri
Study officials:
affiliation: Washington University School of Medicine
name: Jerry Morrissey, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00724451: Observational Study Assessing Chronic Hepatitis C Management in Clinical Practice in Italy (Study P05488 AM1)
Official title: Prospective, Observational, Multicentre Study Evaluating HCV Patients Characteristics of Eligibility and Disease Management in Real Clinical Practice
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Hepatitis C
Hepatitis C, Chronic
Lead sponsor: Merck Sharp & Dohme LLC
Sponsor class: INDUSTRY
First posted: 2008-07-29
Enrollment: 1128
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Consecutive adult patients with chronic hepatitis C seen in common clinical practice at approximately 54 sites in Italy. Treatment for hepatitis C is determined at the local site (pegylated interferon a or b/ribavirin).

Brief summary: The goal of this study is to elucidate the reasons why patients with chronic hepatitis C (CHC) would not be considered eligible for antiviral treatment. The study is conducted in common clinical practice at approximately 54 sites in Italy. Patients deemed eligible for antiviral therapy will be treated at the discretion of the physician with either peginterferon alfa-2a or peginterferon alfa-2b, both in combination with ribavirin, in accordance with approved labeling. A secondary objective of this study is to define "treatment failure" and to evaluate the reasons for treatment discontinuation.

Detailed description: Probability sampling: Consecutive adult patients with chronic hepatitis C in clinical practice at approximately 54 sites in Italy will be included in the study. The decision as to treatment choice falls at the discretion of the treating physician.

Eligibility criteria: Inclusion Criteria:

* Willingness to sign an Informed Consent
* Male and female patients \>=18 years of age with Chronic Hepatitis C
* Not previously treated with Peg-Interferons
* Positive for serum hepatitis C virus (HCV)-ribonucleic acid (RNA)

Exclusion Criteria:

* Previous treatment with peginterferon
* Participation in a therapeutic Good Clinical Practice (GCP) clinical study within 30 days prior to study start

Primary outcomes:
measure: Number of Participants Not Eligible for Antiviral Treatment by Reason for Non-eligibility
timeFrame: Measured at baseline
Secondary outcomes:
measure: Number of Participants Discontinued From Treatment by Reason for Discontinuation
timeFrame: 24 weeks after the end of treatment (total of 48 to 72 weeks)
measure: Number of Participants With Treatment Failure by Reason for Failure
timeFrame: 24 to 48 weeks
Other outcomes:
Locations:
Study officials:
References:
citation: Vukotic R, Gamal N, Andreone P. Prospective, observational real-life study on eligibility for and outcomes of antiviral treatment with peginterferon alpha plus ribavirin in chronic hepatitis C. Dig Liver Dis. 2015 Feb;47(2):151-6. doi: 10.1016/j.dld.2014.11.002. Epub 2014 Nov 13.
Clinical trial NCT04252651: Association of Cytokines With the Development of Complications in Burn and Toxic Epidermal Necrolysis (TENS) Patients
Official title: Association of Cytokines With the Development of Complications in Burn and Toxic Epidermal Necrolysis (TENS) Patients
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Inflammatory Response
Multi Organ Failure
Nosocomial Infection
Deep Vein Thrombosis
Lead sponsor: Joseph M. Still Research Foundation, Inc.
Sponsor class: OTHER
First posted: 2020-02-05
Enrollment: 65
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Samples size will be patients from the burn ICU.

Brief summary: This study will involve blood draws to test for specific cytokines. The study goal is to gain a better understanding of the role of inflammatory response in the development of specific complications in burn and TENS patients.


Eligibility criteria: Inclusion Criteria:

* is ≥18 years of age
* has been admitted to the Joseph M. Still Burn Center at Doctors Hospital Augusta with a burn diagnosis, or TENS OR SJS diagnosis (confirmed or non-confirmed), with an expected length of stay to be at least 7 days
* the subject or their legally authorized representative is able to provide informed consent
* has a negative urine or serum pregnancy test at screening (if female and has potential for pregnancy)

Exclusion Criteria:

* is moribund, or in the opinion of the investigator is not expected to survive
* has sustained an electrical burn

Primary outcomes:
measure: Cytokine Response that develops into complications
timeFrame: up to one year
Secondary outcomes:
Other outcomes:
Locations:
city: Augusta
country: United States
facility: Joseph M. Still Burn Center at Doctors Hospital
state: Georgia
Study officials:
affiliation: Joseph M. Still Research Foundation, Inc.
name: Michael Quinn, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03831451: Stroke Ready: A Stroke Preparedness Brief Intervention
Official title: Stroke Ready: A Stroke Preparedness Brief Intervention
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Stroke
Keywords: stroke preparedness
behavioral intervention
Lead sponsor: University of Michigan
Sponsor class: OTHER
First posted: 2019-02-05
Enrollment: 129
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: Subjects will be randomized to a brief face-to-face stroke preparedness intervention compared to a healthy lifestyle stroke risk reduction intervention. After completing the outcome assessment, subjects will have the opportunity to receive the intervention that they were not initially randomized too.
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This is a randomized controlled behavioral intervention trial to assess the efficacy of a brief intervention to increase stroke preparedness.

Detailed description: This is a randomized controlled behavioral intervention trial to assess the efficacy of a brief intervention to increase stroke preparedness. Subjects will be randomized to a brief face-to-face stroke preparedness intervention compared to a healthy lifestyle stroke risk reduction intervention. The primary outcome is behavioral intent to call 911 using a self-administered survey

Eligibility criteria: Inclusion Criteria:

* over 18 years of age

Exclusion Criteria:

* none

Primary outcomes:
measure: Change in Behavioral Intent to Call 911
timeFrame: Immediately (up to 10 minutes) before the brief intervention and then immediately (up to 10 minutes) after completing the brief intervention
Secondary outcomes:
Other outcomes:
Locations:
city: Flint
country: United States
facility: Hamilton Community Health Network
state: Michigan
city: Flint
country: United States
facility: Hasselbring Senior Center
state: Michigan
Study officials:
affiliation: University of Michigan
name: Lesli Skolarus, MD, MS
role: PRINCIPAL_INVESTIGATOR
References:
citation: Robles MC, Springer MV, Corches CL, Burke JF, Lin CC, Oliver A, Skolarus LE. Stroke Ready Very Brief Intervention Improves Immediate Postintervention Stroke Preparedness. Circ Cardiovasc Qual Outcomes. 2020 Dec;13(12):e006643. doi: 10.1161/CIRCOUTCOMES.120.006643. Epub 2020 Nov 26. No abstract available.
Clinical trial NCT00013351: Restricted Useful Field View as a Risk Factor in Older Adults
Official title: Restricted Useful Field View as a Risk Factor in Older Adults
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Vision Impairment
Keywords: Aging adult, attention, falls, vision
Lead sponsor: VA Office of Research and Development
Sponsor class: FED
First posted: 2001-03-16
Enrollment: 150
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: PROSPECTIVE

Brief summary: The relationship between Useful Field of Vision (UFOV) and falls taken by the elderly will be investigated. UFOV is a test which measures visual attention. The test has been used in correlating the visual attention in the elderly with their driving safety record. The test is administered using a computer and consists of three parts: a) subject views figures which appear in the center of the computer screen and identified them as quickly as possible; b)the subject has to identify figures in the center of the screen while at the same time point to another symbol which will appear in one of eight places on the outer portion of the screen; c) the third section is similar to the second except while the subject is identifying and pointing there is a background noise.


Eligibility criteria: Vision impaired adults at risk for falls

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Decatur
country: United States
facility: VAMC, Decatur
state: Georgia
Study officials:
affiliation: Program Analysis and Review Section (PARS), Rehabilitation Research & Development Service
name: John Fryer, Ph.D. Asst. Director
affiliation: Program Analysis and Review Section (PARS), Rehabilitation Research & Development Service
name: Nancy Rocheleau, Program Analyst
References:
Clinical trial NCT05013151: The Effect of Dates and Castor Oil on the Initiation of Spontaneous Labor in Primigravida Parturients
Official title: The Effect of Dates and Castor Oil on the Initiation of Spontaneous Labor in Primigravida Parturients- a Prospective Randomized Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Effect of Dates and Castor Oil on Spontaneous Labor
Lead sponsor: Carmel Medical Center
Sponsor class: OTHER
First posted: 2021-08-19
Enrollment: 450
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Finding a natural and efficient method to improve the chance of entering spontaneous labor beyond 39 weeks of gestation will address both the medical necessity and the will of many parturients to avoid medical interventions.

In this study we aim to evaluate the effect of dates and castor oil on the initiation of spontaneous labor in primigravida parturients.


Eligibility criteria: Inclusion Criteria:

* Pregnant women who come to the obstetrical emergency department for normal check up between 39+4 and 40+2 weeks of gestation
* Primipara
* Bishop cervical score below 5
* Low risk pregnancy
* Singleton pregnancy
* Vertex presentation
* Women who haven't consumed dates over once a week in month prior the checkup and haven't consumed castor oil prior to enrollment.

Exclusion Criteria:

* Any medical indication for labor induction
* Regular contractions
* Premature rupture of membranes
* Women who consumed dates over once a week in month prior the checkup or consumed castor oil prior to enrollment.

Primary outcomes:
measure: Rates of spontaneous entry into labor
timeFrame: 2 weeks after enrollment
Secondary outcomes:
measure: Cervical ripening- Bishop score
timeFrame: 2 weeks after enrollment
Other outcomes:
Locations:
city: Haifa
country: Israel
facility: Carmel Medical Center
Study officials:
affiliation: Lady Davis Carmel Medical Center
name: Lena Sagi-Dain, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT02375451: Effect of Childhood Radioiodine Therapy on Salivary Function
Official title: Effect of Childhood Radioiodine Therapy on Salivary Function
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Xerostomia
Hyperthyroidism
Thyroid Cancer
Lead sponsor: Boston Children's Hospital
Sponsor class: OTHER
First posted: 2015-03-02
Enrollment: 70
Sex: ALL
Minimum age (years): 3
Maximum age (years): 55
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who have receive I-131 therapy in childhood for thyroid disease, compared to a control group of patients who have never receive I-131 therapy

Brief summary: Radioiodine (I-131) therapy for thyroid disease is known to decrease salivary function in adult patients. The impact of pediatric I-131 exposure on salivary function is unknown. The investigators goals are to answer this question by measuring salivary gland function before and after I-131 administration in children who receive radioiodine therapy at our hospital for thyroid disease.

Detailed description: Radioiodine (I-131) therapy for thyroid disease is known to decrease salivary function in adult patients. The impact of pediatric I-131 exposure on salivary function is unknown. The investigators goals are to answer this question by measuring salivary gland function before and after I-131 administration in children who receive radioiodine therapy at our hospital for thyroid disease. We will use a Modified Shirmer Test to measure saliva production and a questionnaire to evaluation symptoms of xerostomia.

Eligibility criteria: Inclusion Criteria:

* Patients who have been treated with radioiodine therapy
* Patients who have never received radioiodine therapy (negative control group)

Exclusion Criteria:

* Non-English speaking subjects will be excluded due to our lack of translation support resources at this time. Of note, participation in our study cannot benefit participants in any way.

Primary outcomes:
measure: Salivary function (MST value)
timeFrame: 0 to 50 years after radioiodine treatment
measure: Responses to Dry Mouth Questionnaire
timeFrame: At time of visit up to 4 months thereafter.
Secondary outcomes:
measure: Caries history (number of caries noted in dental records)
timeFrame: 1 year before radioiodine administration to 4 months after study visit.
Other outcomes:
Locations:
city: Boston
country: United States
facility: Boston Children's Hospital
state: Massachusetts
Study officials:
References:
Clinical trial NCT03434951: Intrathecal Morphine and Local Infiltration Analgesia in Total Knee Arthroplasty
Official title: Intrathecal Morphine and Local Infiltration Analgesia in Total Knee Arthroplasty, a Randomized Controlled Study
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE4
Conditions: Pain, Postoperative
Lead sponsor: South Carelia Central Hospital
Sponsor class: OTHER
First posted: 2018-02-15
Enrollment: 120
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Double-blinded randomized control study investigating intrathecal morphine as an additive to spinal anesthesia in patients undergoing elective total knee arthroplasty. The investigators aim to include a total of 120 patients, randomized to two equal groups. Participants in the intervention group are administered intrathecal 0,2mg morphine and 12,5mg bupivacaine for spinal anaesthesia. Participants in the placebo group are administered 12.5mg bupivacaine and saline to match the volume of intervention goup. Primary end points are opioid consumption and possible adverse effects.


Eligibility criteria: Inclusion Criteria:

* elective primary total knee arthroplasty
* ASA I-III
* written consent

Exclusion Criteria:

* rearthroplasty
* ASA IV-V
* inadequate spoken finnish for reliable pain assessment
* Dementia or otherwise impaired cognition
* contraindication for any medication or substance used in survey protocol
* weight \<50kg or BMI ≥35 kg/m2
* preoperative SpO2 less than 93%
* clinical suspicion that subject can not use PCA adequately
* history of substance abuse or current excessive use of alcohol
* preoperative use of either pregabalin, gabapentin or strong opiates

Primary outcomes:
measure: intravenous oxycodone consumption
timeFrame: 48 hours
Secondary outcomes:
measure: Adverse effects of 0,2mg intrathecal morphine
timeFrame: 48 hours
measure: Mobilization time
timeFrame: 48 hours
measure: Patient satisfaction
timeFrame: 28 days
Other outcomes:
Locations:
city: Lappeenranta
country: Finland
facility: South Carelia Central Hospital
Study officials:
affiliation: South Carelia Central Hospital
name: Seppo Mustola, MD, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT05208151: Creative Drama in Physiotherapy and Rehabilitation Education
Official title: The Perceived Effect of Communication Skills Education Integrated With Creative Drama on Physiotherapy and Rehabilitation Students' Empathy and Communication Skills to Develop With the Patient: A Randomized Controlled Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Educational Problems
Keywords: Education
Lead sponsor: Acibadem University
Sponsor class: OTHER
First posted: 2022-01-26
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 25
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SCREENING

Brief summary: Candidates who will provide the health services of the future should be ready to provide the safe and best health care services. In order to achieve this, it is recommended to use new training programs and methods that will provide similar situations to the working environment in the training of health workers. There are very few studies on the empathy and communication perceptions that creative drama education will create with the patient on physiotherapy and rehabilitation department students. Therefore, this study, the investigators aimed to investigate the perceived effect of communication skills training integrated with creative drama on physiotherapy and rehabilitation students' empathy and communication skills that will develop with the patient.


Eligibility criteria: Inclusion Criteria:

* Being willing to take FZT 233 Effective Communication with Creative Drama in Health course in any of the fall or spring semesters.

Exclusion Criteria:

* Desire to take FZT 233 Effective Communication with Creative Drama in Health course at his own request.

  * Not wanting to participate in the study
  * Having a diagnosed psychological disorder and/or receiving psychological treatment

Primary outcomes:
measure: interpersonal communication questionnaire
timeFrame: Change from Baseline interpersonal communication questionnaire at 14 weeks
measure: Jefferson Doctor Empathy Scale
timeFrame: Change from Baseline Jefferson Doctor Empathy Scale at 14 weeks
Secondary outcomes:
measure: Visual analog scale-communication
timeFrame: Change from Baseline Visual analog scale at 14 weeks
measure: Visual analog scale-anxiety/stress
timeFrame: Change from Baseline Visual analog scale at 14 weeks
measure: Visual analog scale-motivation
timeFrame: Change from Baseline Visual analog scale at 14 weeks
Other outcomes:
Locations:
city: İstanbul
country: Turkey
facility: Acıbadem University
Study officials:
References: