Clinical trial NCT02074033: Errors in Prescription Antibiotics in Ventilator-associated Pneumonia
Official title: Determination of Errors in Prescription Antibiotics in Ventilator-associated Pneumonia in Unit of Intensive Care of Clinical Hospital of Federal University of Uberlandia - Brazil
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Pneumonia
Lead sponsor: Federal University of Uberlandia
Sponsor class: OTHER
First posted: 2014-02-28
Enrollment: 130
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: The study is a retrospective study to evaluate the use of antibiotics in the ventilator-associated pneumonia (PAV) in the Intensive Care Unit of the Adult Clinical Hospital of the Federal University of Uberlândia. The UnitAdult Intensive Care has complexity level III and consists of 30 beds.O number of statistically significant sample is 130 patients.

Brief summary: The infection is a major risk to hospitalized patients, especially those admitted to the Intensive Care Unit (ICU) and an unfavorable factor in the outcome of critically ill patients, increasing costs and prolonging hospitalization hospitalar. The ventilator-associated pneumonia (PAV) is considered the most prevalent nosocomial infection in the ICU, occurring in 9% to 68% of patients with prosthetic ventilatória.Due to the high rate of PAV and mortality related to it, is very important both prescription and administration of antibiotics correctly, as deescalation or escalation according the result of cultures.Therefore, the objectives of this study is assess if whether the antibiotic prescribed of ventilator-associated pneumonia following the orientation of literature. Will also be assessed the rate of PAV in patients critically ill adults, the main microorganisms responsible by PAV and determining antimicrobial susceptibility.

Detailed description: In patients who had a diagnosis of ventilator-associated pneumonia by asssistente physician will be assessed initially prescribed antibiotics empirically and what conduct adopted after culture results.

We will be examined whether the antibiotic prescribed following the orientation of literature, considering the dose, interval between doses, dose adjustment for renal failure infusion time, treatment time and conduct after the culture results (deescalation, escalation or maintenance of antimicrobial initially prescribed ) . The deescalation consists of discontinuing the use of antimicrobial or antibiotic change to another with lower coverage and spectrum is performed, escalation occurs when adding a new antibiotic or antibiotic to change the coverage of other larger spectrum after culture results .

Eligibility criteria: Inclusion Criteria:

* Be 18 years of age;
* Having the diagnosis of ventilator-associated pneumonia.

Exclusion Criteria:

* Be under 18 years of age;

Primary outcomes:
measure: Determination of Errors in Prescription Antibiotics in Ventilator-associated Pneumonia in Unit of Intensive Care of Clinical Hospital of Federal University of Uberlandia - Brazil
timeFrame: six months
Secondary outcomes:
Other outcomes:
Locations:
city: Uberlândia
country: Brazil
facility: Ana Carolina Souza Oliveira
state: Minas Gerais
Study officials:
affiliation: Federal University of Uberlandia
name: Ana Carolina Souza Oliveira
role: PRINCIPAL_INVESTIGATOR
affiliation: Federal University of Uberlandia
name: Denise Von Dollinger de Brito
role: PRINCIPAL_INVESTIGATOR
affiliation: Federal University of Uberlandia
name: Thúlio Marquez Cunha
role: PRINCIPAL_INVESTIGATOR
affiliation: Federal University of Uberlandia
name: Fabiola Alves Gomes
role: PRINCIPAL_INVESTIGATOR
References: