louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03814070: Prosthesis and Implant Survival in Immediately Loaded Temporary Full Arch Restorations
Official title: Prosthesis and Implant Survival in Immediately Loaded Full Arch Restorations Using Fiber Reinforced Versus Non-reinforced Temporary Frameworks: A Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Completely Edentulous Patients
Lead sponsor: Cairo University
Sponsor class: OTHER
First posted: 2019-01-23
Enrollment: 114
Sex: ALL
Minimum age (years): 30
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: In immediate loading of implants of completely edentulous patients, the most common post-surgical complication following the surgery noted in the dental literature is fracture of the provisional restoration with rates ranging from 4.17% to 41%. Most of these fractures occur because polymethyl methacrylate (PMMA) materials are inadequate and have low rigidity to withstand extended periods of heavy occlusal use.

Fractures of full arch provisional restorations during healing are concerning, because they eliminate cross-arch stabilization and disrupt stress distribution patterns which might jeopardize implant osseointegration affecting the survival rates for implants. Therefore, it is important to look for another material that has higher rigidity than PMMA and can withstand masticatory forces for extended periods without fractures or load concentration on the implants during the osseointegration period.


Eligibility criteria: Inclusion Criteria:

* Completely edentulous patients.
* Patients with proper amount of attached gingiva (≥2 mm)

Exclusion Criteria:

* Patients having a medical condition that absolutely contraindicates implant placement.
* Patients with uncontrolled diabetes, assessed by measuring glycosylated hemoglobin (HbA1c). (greater than 6.4 percent)
* Potentially uncooperative patients who are not willing to go through the proposed interventions.
* Moderate-to-heavy daily smokers\* (who report consuming at least 11 cigarettes/day).
* Patients with history of bruxism
* If insertion torque for the implants is less than 35 Ncm

Primary outcomes:
measure: Prosthesis survival
timeFrame: 4 months
Secondary outcomes:
measure: Implant survival
timeFrame: 4 months
measure: Peri-implant crestal bone loss during healing
timeFrame: 4 months
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04603170: Relationships of Executive Functions, Severity of Psychiatric Symptoms With Response to Therapy
Official title: University of Bojnord
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Patient Acceptance of Health Care
Lead sponsor: University of Bojnord
Sponsor class: OTHER
First posted: 2020-10-26
Enrollment: 164
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The statistical population included all adult outpatients with anxiety and depression disorders who referred to psychiatric offices in Bojnord city Sample was selected among the clients of psychiatric offices who received the diagnosis of anxiety and depression disorders and volunteer to participate in the study were sample (n=164)

Brief summary: This study was conducted to investigate the moderating role of executive functions in the relationship between the severity of psychiatric symptoms and response to therapy. The statistical population of this study was all outpatients with anxiety disorders and depression who referred to psychiatric clinics.

Detailed description: This study was conducted to investigate the moderating role of executive functions in the relationship between the severity of psychiatric symptoms and response to drug therapy in depressed and anxious patients. The statistical population of this study was all outpatients with anxiety disorders and depression who referred to psychiatric clinics. 164 participants completed Outcome Questionnaire, Brief Symptom Inventory, and Behavior Rating Inventory of Executive Function (BRIEF).

Eligibility criteria: Inclusion Criteria:

receiving a diagnosis of anxiety and depression disorders, age over 18 years, and taking drug medication prescribed by psychiatrists for at least one month.-

Exclusion Criteria:

* having psychotic disorders, age under 18 years and absence from treatment.

Primary outcomes:
measure: Outcome questionnaire
timeFrame: ONE WEEK
measure: Brief Symptom Inventory
timeFrame: ONE WEEK
measure: Behavior Rating Inventory of Executive Function
timeFrame: ONE WEEK
Secondary outcomes:
Other outcomes:
Locations:
city: Bojnourd
country: Iran, Islamic Republic of
facility: Malahat Amani
state: North Khorsan
Study officials:
affiliation: University of Bojnord
name: Malahat amani, ph.d
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00458770: Study of Hypothalamic Metabolism in Spontaneous Cluster Headache Attacks
Official title: Study of Hypothalamic Metabolism in Spontaneous Cluster Headache Attacks
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Cluster Headache
Keywords: Comparison of a spontaneous acute cluster headache attack and rest (no pain) in ten patients with cluster headache defined with IHS criteria
Lead sponsor: Assistance Publique Hopitaux De Marseille
Sponsor class: OTHER
First posted: 2007-04-11
Enrollment: 1
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: Cluster headache is characterized by unilateral excruciating head pain and autonomic dysfunction. Hypothalamic overactivity was observed in nitrate-induced cluster-headache and in only one case of spontaneous cluster headache 'Sprenger et al, 2004). This prompted the application of hypothalamic deep brain stimulation. The aim of this data is to precise the localisation of the hypothalamic activation.


Eligibility criteria: Inclusion Criteria:

* cluster headache in crisis
* no serious illnesses in progress as cancer, autoimmune disease, liver disease
* patient without chronic psychiatric disease excluding moderate and reactional depression
* no demential disease
* no anxious or depressive disease
* no contraindication to PET scan (pregnancy and breast-feeding)
* social security cover
* written informed consent

Exclusion Criteria:

* No effective contraception taken
* unable to realize a decubitus of 15 minutes long

Primary outcomes:
measure: To confirm the existence of a hypothalamic promoter at the origin of Spontaneous Cluster Headache Attacks
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Marseille
country: France
facility: Pôle de Neurosciences Cliniques CHU Timone
Study officials:
affiliation: Pôle de Neurosciences Cliniques CHU Timone, 204 rue St Pierre, Marseille 13385 cedex 5 France
name: Anne DONNET, PH
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05270070: Digital Versus Traditional Booking System for Clinical Appointments
Official title: A Pilot Study: Comparing Digital to Traditional Booking System for Clinical Appointments
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Health Informatics
Keywords: digital booking
telephone booking
Lead sponsor: Canadian Forces Health Services Centre Ottawa
Sponsor class: OTHER
Collaborators: name: Canadian Department of National Defense
First posted: 2022-03-08
Enrollment: 61
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients referred to the Canadian Forces Health Services Centre for physical medicine and rehabilitation consultation.

Brief summary: In the Canadian Forces Health Services Ottawa clinical administrative resources are currently constrained, directly impacting workflow and patient care. Given the nature of the current EMR and digital health infrastructure, DBS is not currently being employed. Therefore, investigators sought to determine the relative benefit of using an online booking system when compared to TB. To the investigator's knowledge, validation of this type has not been conducted in this setting.

Detailed description: Introduction: The impact of digital booking systems (DBS) on clinical care, administrative efficiency and health care costs have not previously been explored in the Canadian Forces Health Services. No show rates were shown to be reduced by 6-42% percent compared to traditional booking (TB) depending on the system and the clinic. Therefore, investigators sought to determine the relative benefit of using an online booking system when compared to TB.

Methods: Main outcome variables included total time for booking all patients between groups including the start to end dates of each intervention, the number of hours spent on the phone / answering emails, and the number of phone calls and emails received, and the number of phone calls / emails regarding booking problems, cancellations, changes and no shows. Descriptive and mean comparative statistics will be used to determine any differences between groups.

Eligibility criteria: Inclusion Criteria:

* Patients that have never been seen for new consultations

Exclusion Criteria:

* none

Primary outcomes:
measure: Total time for booking all patients
timeFrame: ~3 months
Secondary outcomes:
measure: Percent of Patients Booked
timeFrame: ~3 months
measure: Average Time Spent per Patient
timeFrame: ~3 months
Other outcomes:
Locations:
city: Ottawa
country: Canada
facility: Canadian Forces Health Services Centre
state: Ontario
Study officials:
affiliation: Canadian Forces Health Services Centre
name: Gaurav Gupta, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02640170: Intraoperative Imaging With ICG Registry
Official title: Intraoperative Imaging With ICG Registry
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Lung Nodule, Breast, Kidney,Parathyroid, Mediastinal, Skin Mass, Soft Tissue, Prostate, Stomach Pleural, Head and Neck, and Are at Risk of Recurrence
Lead sponsor: Abramson Cancer Center at Penn Medicine
Sponsor class: OTHER
First posted: 2015-12-28
Enrollment: 291
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with a diagnosis of any resectable solid tumor, including but not limited to lung nodule, breast, kidney,parathyroid, mediastinal, skin mass, soft tissue, prostate, stomach pleural, head and neck, and are at risk of recurrence

Brief summary: The purpose of this registry is to monitor the rate of recurrence in patients who undergo cancer surgery.

Detailed description: Our objective is to collect prospective data on cancer subjects who undergo surgery and intraoperative imaging. The registry will include (but not limited to) cancer type, stage, intraoperative challenges to the surgeon, usage and results of intraoperative imaging, and recurrence surveillance.

In this protocol, subjects that receive intraoperative imaging will provide us the opportunity to record what tissues fluoresce in the operating room, and then to identify if these lesions are cancer when the histopathology is performed. Also, we will monitor any side effects or potential toxicities that may occur. This data can then be used to predict if a subject is more likely to develop a local recurrence due to missed cancer cells, metastatic lymph nodes or synchronous lesions.

Eligibility criteria: Inclusion Criteria:

Inclkusion Criteria

* Adult patients \>= 18 years of age
* Patients presenting with any solid tumor and/or diseased tissue even benign nodules presumed to be resectable and are at risk for recurrence.
* Good operative candidate as determined by the treating physician and/or multidisciplinary team
* Subject capable of giving informed consent and participating in the process of consent.

Exclusion Criteria None

Primary outcomes:
measure: Number of subjects registered
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Philadelphia
country: United States
facility: Abramson Cancer Center of the University of Pennsylvania
state: Pennsylvania
Study officials:
affiliation: Abramson Cancer Center at Penn Medicine
name: Sunil Singhal, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Newton AD, Predina JD, Corbett CJ, Frenzel-Sulyok LG, Xia L, Petersson EJ, Tsourkas A, Nie S, Delikatny EJ, Singhal S. Optimization of Second Window Indocyanine Green for Intraoperative Near-Infrared Imaging of Thoracic Malignancy. J Am Coll Surg. 2019 Feb;228(2):188-197. doi: 10.1016/j.jamcollsurg.2018.11.003. Epub 2018 Nov 22.
Clinical trial NCT02411942: Study Comparing Adapalene Gel 0.3% to Differin® and Both to a Placebo Control in Treatment of Acne Vulgaris
Official title: A Multi-Center, Double-Blind, Randomized, Placebo Controlled, Parallel-Group Study Comparing Adapalene Gel 0.3% to Differin® (Adapalene Gel 0.3%) and Both Active Treatments to a Placebo Control in the Treatment of Acne Vulgaris
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Acne Vulgaris
Lead sponsor: Taro Pharmaceuticals USA
Sponsor class: INDUSTRY
First posted: 2015-04-08
Enrollment: 753
Sex: ALL
Minimum age (years): 12
Maximum age (years): 40
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The objectives of this study are to evaluate the therapeutic equivalence and safety of Adapalene Gel 0.3% and Differin® (adapalene gel 0.3%).

Detailed description: The objectives of this study are to evaluate the therapeutic equivalence and safety of Adapalene Gel 0.3% and Differin® (adapalene gel 0.3%) in the treatment of acne vulgaris and to demonstrate the superiority of the efficacy of the test and reference products over the placebo.

Eligibility criteria: Inclusion Criteria:

* Healthy male or non-pregnant female aged ≥ 12 and ≤ 40 years with a clinical diagnosis of acne vulgaris.
* Subjects aged 18 years and older must have provided written consent. Subjects aged 12 to 17 years must have provided written assent accompanied by written consent from their legally acceptable representative. All subjects or their legally acceptable representatives must sign Health Insurance Portability and Accountability Act authorization.
* Must have a minimum of ≥ 25 non-inflammatory lesions and ≥ 20 inflammatory lesions and ≤ 2 nodulocystic lesions at baseline on the face.
* Must have a definite clinical diagnosis of acne vulgaris severity grade 2, 3, or 4 as per the Investigator's Global Assessment.

Exclusion Criteria:

* Female subjects who are pregnant, nursing or planning to become pregnant during study participation.
* Have a history of hypersensitivity or allergy to adapalene, retinoids and/or any of the study medication ingredients.
* Presence of any skin condition that would interfere with the diagnosis or assessment of acne vulgaris.

Primary outcomes:
measure: Change in inflammatory lesion counts
timeFrame: Week 12
measure: Change in non-inflammatory lesion counts
timeFrame: Week 12
Secondary outcomes:
measure: Clinical response of success
timeFrame: Week 12
Other outcomes:
Locations:
Study officials:
affiliation: http://catawbaresearch.com/contact/
name: Catawba Research
role: STUDY_CHAIR
References:
Clinical trial NCT06734442: Thoracoscopy for Idiopathic Pneumothorax in Children
Official title: Surgical Management of Primary Spontaneous Pneumothorax in Children
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Spontaneous Pneumothorax
Idiopathic Pneumothorax
Bleb Lung
Child, Only
Keywords: Video-Assisted Thoracoscopy
Spontaneous Idiopathic Pneumothorax
Blebectomy
Lung Wedge
Pleural Abrasion
Retrospective Study
Child
Lead sponsor: University Hospital, Clermont-Ferrand
Sponsor class: OTHER
Collaborators: name: Central Hospital, Nancy, France
First posted: 2024-12-16
Enrollment: 23
Sex: ALL
Minimum age (years): 0
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who were operated from 2014 to 2022

Brief summary: The goal of this retrospective study is to describe the outcomes of spontaneous idiopathic pneumothorax treated by thoracoscopy with pleural abrasion and blebectomy.

The main questions it aims to answer are:

* are there risk factors leading to pneumothorax recurrence?
* are pleural abrasion and blebectomy really diminishing the recurrence of pneumothorax?

Detailed description: The investigators describe the outcomes of the participants: length of stay, operating time, type and time before recurrence, occurrence of contralateral pneumothorax also treated by thoracoscopy, with pleural abrasion and blebectomy

Eligibility criteria: Inclusion Criteria:

* Patients younger than 18 years old who had a video-assisted thoracoscopy with pleural abrasion and blebectomy for spontaneous idiopathic pneumothorax

Exclusion Criteria:

* Patients older than 18 years old who had a video-assisted thoracoscopy with pleural abrasion and blebectomy for spontaneous idiopathic pneumothorax

Primary outcomes:
measure: Recurrence of pneumothorax
timeFrame: Through study completion, an average of 2 years
Secondary outcomes:
measure: Other complications after surgery
timeFrame: Through study completion, an average of 2 years
measure: Operating Time
timeFrame: Intraoperative
measure: Length of stay
timeFrame: From admission to discharge home, up to 20 days
measure: The time between the surgery and postoperative consultation dates
timeFrame: Through study completion, an average of 2 years
Other outcomes:
Locations:
city: Clermont-Ferrand
country: France
facility: University Hospital, Clermont-Ferrand
state: Auvergne
Study officials:
References:
citation: Demir M, Akin M, Kaba M, Filiz S, Sever N, Karadag CA, Dokucu AI. Thoracoscopic Resection in the Treatment of Spontaneous Pneumothorax. Sisli Etfal Hastan Tip Bul. 2020 Mar 25;54(1):94-97. doi: 10.14744/SEMB.2018.88310. eCollection 2020.
citation: Pogorelic Z, Gudelj R, Bjelanovic D, Jukic M, Elezovic Baloevic S, Glumac S, Furlan D. Management of the Pediatric Spontaneous Pneumothorax: The Role of Video-Assisted Thoracoscopic Surgery. J Laparoendosc Adv Surg Tech A. 2020 May;30(5):569-575. doi: 10.1089/lap.2019.0742. Epub 2020 Mar 11.
Clinical trial NCT06298942: Naturally Banded Versus Synthetic Banding of Sleeve Gastrectomy
Official title: Naturally Banded Versus Synthetic Banding of Sleeve Gastrectomy
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Obesity, Morbid
Lead sponsor: Minia University
Sponsor class: OTHER
First posted: 2024-03-07
Enrollment: 250
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: to compare banding sleeve gastrectomy using silicone ring Versus using natural flap ( round ligament of the liver)

Detailed description: to compare banding sleeve gastrectomy using silicone ring Versus using natural flap ( round ligament of the liver) as regard weight loss, complications rat and cost

Eligibility criteria: Inclusion Criteria:

* obese patients with BMI more than 40 with or without co-morbidity or more than 35 with co-morbidity
* patients fit for laparoscopic surgery
* give approval to share in the study

Exclusion Criteria:

* patients refused to share in the study
* patients unfit for surgery
* patients aged less than 18 and older than 65
* patient with previous upper abdominal surgery either for obesity or other diseases
* revisional bariatric procedures

Primary outcomes:
measure: total cost
timeFrame: 12 hours
measure: food intolerance
timeFrame: 1 year
Secondary outcomes:
measure: %EWL
timeFrame: 1 year
measure: complications rate
timeFrame: 1 year
measure: improvement of comorbidities
timeFrame: 1 year
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04007042: Validation of a Short Questionnaire (SSI) for Sleep Disorders in Patients With Alcohol
Official title: Validation of a Short Questionnaire (SSI) for Sleep Disorders in Patients With Alcohol
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Alcohol Dependence
Sleep Disorder
Lead sponsor: Centre Hospitalier Universitaire de Nīmes
Sponsor class: OTHER
First posted: 2019-07-05
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients with alcohol abuse or dependence

Brief summary: Sleep disorders are very common in alcohol patients (40-90% according to studies) These sleep disorders may persist after withdrawal and represent a major factor in relapse.

In a previous study, the investigators validated a simple sleep questionnaire (the "Short Sleep Index = SSI") from a multicentre series of 602 American patients (Perney et al., Alcohol Alcohol 2012) The SSI is obtained from the Hamilton score (baseline score for anxiety and depression)

Detailed description: to compare the SSI with a reference sleep questionnaire (Pittsburg Quality Sleep Index) in alcohol patients in different situations: Ambulatory or hospitalization

Eligibility criteria: Inclusion Criteria Sick people with alcohol abuse or dependence Inpatient or outpatient follow-up (Nîmes University Hospital, Grau du Roi Hospital, Montpellier, Centre de Soins d'Accompagnement et de Prévention en Addictologie (CSAPA of Nîmes University Hospital) Agreeing to answer the questionnaire Not having a cognitive deficit or psychiatric pathology that makes interrogation unreliable

* Exclusion criteria : NA

Primary outcomes:
measure: to compare the SSI with a reference sleep questionnaire (Pittsburg Quality Sleep Index
timeFrame: Day 1
Secondary outcomes:
measure: compare the duration of these 2 tests
timeFrame: Day 1
Other outcomes:
Locations:
Study officials:
References: