Clinical trial NCT04566471: Palmoplantar Pustulosis and Generalized Pustular Psoriasis: A National Population-based Analysis of Prevalence
Official title: Palmoplantar Pustulosis and Generalized Pustular Psoriasis: A National Population-based Analysis of Prevalence
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Palmoplantar Pustulosis
Generalized Pustular Psoriasis
Keywords: Generalized pustular psoriasis
Palmoplantar pustulosis
Urban Employee Basic Medical Insurance (UEBMI) data
prevalence
incidence
Lead sponsor: Peking University Third Hospital
Sponsor class: OTHER
First posted: 2020-09-28
Enrollment: 200
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: This study used the Urban Employee Basic Medical Insurance (UEBMI) data from 2012 to 2016 to calculate the epidemiological characteristics of palmoplantar pustulosis and generalized pustular psoriasis. The database includes basic medical insurance data for urban workers and basic medical insurance data for urban residents, which covers 31 provinces, municipalities and autonomous regions. By the end of 2016, the number of people participating in the national basic medical insurance exceeded 1.3 billion, and the coverage rate of the insurance was stable at over 95%.

The database is composed of an insurance coverage database and a reimbursement settlement database. The insurance coverage database involves demographic information, insurance information and payment information; and the reimbursement settlement database involves medical information, disease information and expense information.

Brief summary: This study plans to calculate the prevalence and incidence of palmoplantar pustulosis and generalized pustular psoriasis based on the national medical insurance data and analyze the composition characteristics and some clinical features of patients, through taking into account of the research status of palmoplantar pustulosis and generalized pustular psoriasis and the characteristics of medical insurance data.


Eligibility criteria: Inclusion Criteria:

* The insured population of the national urban employee basic medical insurance and the urban resident basic medical insurance from January 1, 2012, to December 31, 2016 (60 months) (the denominator)
* The patients have been diagnosed with palmoplantar pustulosis or generalized pustular psoriasis (including disease name, English abbreviation and ICD code)
* Both outpatient and inpatient patients are included

Exclusion Criteria:

* The individuals whose information is only contained in the reimbursement settlement database but not in the insurance coverage database will be considered as invalid reimbursement individuals and be excluded from the study (the denominator)
* The patients have been diagnosed with non-PPP and -GPP diseases, such as pustular psoriasis in palm and toe, pustular arthritis osteitis and SAPHO syndrome

Primary outcomes:
measure: prevalence of Palmoplantar pustulosis
timeFrame: From 2012 to 2016 in the Urban Employee Basic Medical Insurance (UEBMI) data of China
measure: prevalence of Generalized pustular psoriasis
timeFrame: From 2012 to 2016 in the Urban Employee Basic Medical Insurance (UEBMI) data of China
Secondary outcomes:
measure: incidence of Palmoplantar pustulosis
timeFrame: From 2012 to 2016 in the Urban Employee Basic Medical Insurance (UEBMI) data of China
measure: incidence of Generalized pustular psoriasis
timeFrame: From 2012 to 2016 in the Urban Employee Basic Medical Insurance (UEBMI) data of China
measure: Economic burden of Palmoplantar pustulosis
timeFrame: From 2012 to 2016 in the Urban Employee Basic Medical Insurance (UEBMI) data of China
measure: Economic burden of Generalized pustular psoriasis
timeFrame: From 2012 to 2016 in the Urban Employee Basic Medical Insurance (UEBMI) data of China
Other outcomes:
Locations:
Study officials:
affiliation: Peking University Third Hospital
name: Siyan Zhan, PhD
role: PRINCIPAL_INVESTIGATOR
References: