Clinical trial NCT04939298: Ultrasound Evaluation of Abdominal Muscle Thickness During Mechanical Ventilation
Official title: Ultrasound Evaluation of Abdominal Muscle Thickness During Mechanical Ventilation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Ventilation Therapy; Complications
Keywords: abdominal muscles
ultrasound
Lead sponsor: Centre Hospitalier de Roanne
Sponsor class: OTHER
Collaborators: name: Centre Hospitalier Universitaire de Saint Etienne
First posted: 2021-06-25
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Weakness of respiratory muscles is frequent after several days of mechanical ventilation. Thereby an acquired diaphragm weakness has been demonstrated, linked to an atrophy which may be identified by a decrease of muscle thickness in echography. This study aims to evaluate with ultrasound the variation of thickness of abdominal muscles after 7 days of mechanical ventilation.

Detailed description: Weakness of respiratory muscles is frequent after several days of mechanical ventilation. Thereby an acquired diaphragm weakness has been demonstrated, linked to an atrophy which may be identified by a decrease of muscle thickness in echography. Weakness of expiratory muscles is also frequent after 7 days of mechanical ventilation, however his cause is not clear: is it present at admission notably in elderly patients, or acquired on mechanical ventilation ? Ultrasound allows to measure the thickness of abdominal muscles which correlates with their strength. This study aims to evaluate with ultrasound the variation of thickness of abdominal muscles after 7 days of mechanical ventilation.

Eligibility criteria: Inclusion Criteria:

* Patient affiliated or entitled to a social security plan
* Expected duration of mechanical ventilation \> 7 days
* Trusted person/relative who has signed a consent to participate in the study

Exclusion Criteria:

* Patient with a pre-existing neuromuscular pathology
* No access to ultrasound Windows (dressing, drainages...)
* Patient transferred from another intensive care unit
* Patient Under guardianship or curators

Primary outcomes:
measure: Thickness of the abdominal muscles (mm)
timeFrame: Day 7
Secondary outcomes:
measure: Thickness of the rectus abdominal muscles (mm)
timeFrame: Day 7
measure: Thickness of the external oblique abdominal muscles (mm)
timeFrame: Day 7
measure: Thickness of the internal oblique abdominal muscles (mm)
timeFrame: Day 7
measure: Thickness of the transverse abdominal muscles (mm)
timeFrame: Day 7
measure: Diaphragmatic thickness (mm)
timeFrame: Day 7
measure: Diaphragmatic thickness (mm)
timeFrame: Immediately after the successful extubation of the patient
measure: Number of day with a contraction of the transverse abdominal muscle
timeFrame: From day 1 to day 7
measure: Caught peak expiratory flow (CPEF) (cmH2O)
timeFrame: Day 7
measure: Maximum expiratory pressure (l/min)
timeFrame: Day 7
measure: Thickness of the external oblique abdominal muscle (mm)
timeFrame: Immediately after the successful extubation of the patient
measure: Thickness of the internal oblique abdominal muscle (mm)
timeFrame: Immediately after the successful extubation of the patient
measure: Thickness of the transverse abdominal muscle (mm)
timeFrame: Immediately after the successful extubation of the patient
measure: Thickness of the rectus abdominal muscle (mm)
timeFrame: Immediately after the successful extubation of the patient
measure: Number of day between day 7 and successful extubation day (days)
timeFrame: From Day 7 to the day when the patient will be extubated successfully
measure: Duration of sedation (Day)
timeFrame: At intensive care unit discharge
measure: Duration of curarization (Day)
timeFrame: At intensive care unit discharge
Other outcomes:
Locations:
city: Roanne
country: France
facility: Centre Hospitalier de Roanne
Study officials:
affiliation: HOPITAL DE ROANNE
name: Pascal Beuret, MD
role: PRINCIPAL_INVESTIGATOR
References: