louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT03427697: Effect of VR and Accommdation Relax on Controlling Myopia in Children
Official title: Effect of Virtual Reality and Accommodation Relax Techniques in Combination on Controlling Myopia Development in School-aged Children
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Myopia
Accommodation Spasm
Children
Lead sponsor: Beijing Tongren Hospital
Sponsor class: OTHER
First posted: 2018-02-09
Enrollment: 1000
Sex: ALL
Minimum age (years): 6
Maximum age (years): 9
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: This study evaluates the effect of virtual reality and accommodation relax technique on controlling onset and development of myopia in school-aged children. Half of the children will receive head-mounted video display which shows video with virtual reality and accommodation relax technique in combination, while the other half will receive no intervention.


Eligibility criteria: Inclusion Criteria:

* Best corrected visual acuity \>=20/20 for each eye;
* Astigmastism less than 1.5 D;
* Anisometropia less than 1.0D;
* No other ocular or systematic diseases;

Exclusion Criteria:

* Can not endure virtual reality video;
* Can not cooperate with ocular examinations;
* Receiving other interventions for controlling myopia;

Primary outcomes:
measure: Myopia progression
timeFrame: One year
measure: Axial elongation
timeFrame: One year
Secondary outcomes:
measure: Accommodative lag
timeFrame: One week and One month
Other outcomes:
Locations:
city: Beijing
country: China
facility: Beijing Tongren Hospital
state: Beijing
Study officials:
References:
Clinical trial NCT00974597: Comparison of AWBAT™-D and MEPILEX® AG for Treatment of Donor Sites in Burn Surgery
Official title: A Randomized, Prospective Comparison of AWBAT™-D and MEPILEX® AG for Treatment of Donor Sites in Burn Surgery
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Burn Surgery
Keywords: burn
donor site
treatment of burns
Treatment of Donor Sites
Lead sponsor: Aubrey Inc.
Sponsor class: INDUSTRY
First posted: 2009-09-10
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to examine AWBAT™-D compared to Mepilex® Ag for the treatment of donor sites in burn surgery.


Eligibility criteria: Inclusion Criteria:

* Burn wounds requiring skin grafting
* Matched donor sites available
* 1-30% TBSA

Exclusion Criteria:

* Severe inhalation injury
* Pregnancy
* Co-morbidity which may compromise healing
* Known allergy to pork or pork products

Primary outcomes:
measure: Compare rate of healing of donor sites
timeFrame: 6 month follow-up
Secondary outcomes:
measure: Compare complication rates
timeFrame: 6 month follow-up
measure: Compare patient reported perception of pain
timeFrame: 6 month follow-up
measure: Compare clinical outcome (scarring)
timeFrame: 6 month follow-up
Other outcomes:
Locations:
city: Augusta
country: United States
facility: Doctors Hospital of Augusta
state: Georgia
Study officials:
References:
Clinical trial NCT01185197: Myfortic® for Minimal Change Nephrotic Syndrome (MCNS): a Randomized Study
Official title: Myfortic® Combined With Low-dose Steroid in Minimal Change Nephrotic Syndrome
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Nephrosis, Lipoid
Keywords: Minimal Change Nephrotic Syndrome
Corticosteroid
Mycophenolate
Remission
Safety
Lead sponsor: The University of Hong Kong
Sponsor class: OTHER
First posted: 2010-08-19
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Study objective: To investigate the potential therapeutic efficacy of enteric-coated mycophenolate sodium combined with low-dose corticosteroid as first-line treatment for minimal change nephrotic syndrome (MCNS).

Detailed description: This is a prospective, open-label, randomized study in which patients who present for the first time with a clinical diagnosis of idiopathic MCNS proven on renal biopsy will be assigned to either conventional standard-dose prednisolone monotherapy or myfortic combined with low-dose prednisolone treatment for 6 months. Clinical response and relapse rates within 6 months of treatment cessation will be the main outcome parameters.

Eligibility criteria: Inclusion Criteria:

* Male or female 18 - 65 years of age
* First histologic diagnosis of MCNS
* Proteinuria \> 3.5 g/day
* Patients who are willing to give written, informed consent

Exclusion Criteria:

* Presence of secondary causes of MCNS
* History of glomerular disease including MCNS
* eGFR \< 50 ml/min/1.73m2
* Renal histology showing pathologies other than MCNS
* Female of child-bearing age who are unwilling to practice effective contraception
* Patients simultaneously participating in another study or who have participated in another study within the last 30 days of entry into this study

Primary outcomes:
measure: Complete remission (24 hour urine protein < 0.3 g)
timeFrame: at 6 months
Secondary outcomes:
measure: Occurrence of cushingoid facies, striae, acne, weight gain, GI disturbance, cytopenia, infection
timeFrame: at 6 months
Other outcomes:
Locations:
city: Hong Kong
country: China
facility: Queen Mary Hospital
Study officials:
affiliation: The University of Hong Kong
name: Sydney CW Tang, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Azukaitis K, Palmer SC, Strippoli GF, Hodson EM. Interventions for minimal change disease in adults with nephrotic syndrome. Cochrane Database Syst Rev. 2022 Mar 1;3(3):CD001537. doi: 10.1002/14651858.CD001537.pub5.
citation: Ma MKM, Yap DYH, Li CL, Mok MMY, Chan GCW, Kwan LPY, Lai KN, Tang SCW. Low-dose corticosteroid and mycophenolate for primary treatment of minimal change disease. QJM. 2020 Jun 1;113(6):399-403. doi: 10.1093/qjmed/hcz297.
Clinical trial NCT01943097: Evaluation of 18F-dopa and 123I-MIBG Uptake in the Patients With Neuroblastoma
Official title: The Evaluation of the 6-[18F]Fluoro-levo-dopa and 123I-MIBG Uptake in the Patients With Neuroblastoma
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Neuroblastoma
Lead sponsor: National Taiwan University Hospital
Sponsor class: OTHER
First posted: 2013-09-16
Enrollment: 160
Sex: ALL
Maximum age (years): 30
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: CASE_CROSSOVER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Patients With Neuroblastoma

Brief summary: Neuroblastic tumors are childhood neoplasms that possess amino acid decarboxylase (AADC) activity and Meta-iodobenzylguanidine(MIBG), they can theoretically be imaged by (18)F-fluorodihydroxyphenylalanine ((18)F-FDOPA) and (123)I-Meta-iodobenzylguanidine((123)I-MIBG) PET, they are new and specific diagnostic and follow-up tools for neuroendocrine tumors. In this study, we explored the accuracy and clinical role of (18)F-FDOPA and (123)I-MIBG PET in neuroblastic tumors.

METHODS:

Patients with tissue-proven neuroblastic tumors receiving (18)F-FDOPA PET or (123)I-MIBG at initial diagnosis or during follow-ups were enrolled. The sensitivity and specificity of (18)F-FDOPA or (123)I-MIBG PET were compared to each other and compared to(18)F-FDG PET, using tumor histology as the standard.


Eligibility criteria: Inclusion Criteria:

* (1) Diagnosed by clinical criteria(one of below)

  1. Proved as Neuroblastoma by a pathological section
  2. Bone meta with 24 hrs urine VMA(Vanillylmandelic acid )or HVA (Homovanillic acid) elevated
  3. CT or MRI found tumor around adrenal gland or Neuroblastic tumor
* (2) Age between 0-30 years old，Body weight over 2.5kg
* (3) Signed Inform Consent Form

Exclusion Criteria:

* (1)AST and ALT \> 200U/L、Cre \> 2.5mg/dl
* (2)Allerg to 18F-dopa、123I-MIBG
* (3)Subject not fit this study(assessed by PI)
* (4)No more need to arrenge PET because disease progress, assessed by VS

Primary outcomes:
measure: The maximum standardized uptake value and tumor-to-liver uptake ratio
timeFrame: Outcome will be measured in one week after performed.
Secondary outcomes:
Other outcomes:
Locations:
city: Taipei
country: Taiwan
facility: National Taiwan University Children Hospital
Study officials:
References:
Clinical trial NCT06756997: The Effect of Different Sensory Conditions on Sensory Interaction in Balance
Official title: The Effect of Different Sensory Conditions on Sensory Interaction in Balance
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Balance Assessment
Sensory Science
Keywords: balance assessment
sensory condition
Lead sponsor: Bezmialem Vakif University
Sponsor class: OTHER
First posted: 2025-01-03
Enrollment: 31
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: The population of the study will consist of 23 volunteer healthy young adult subjects aged 18-45 years. All subjects will be evaluated and tested at Bezmialem Vakif University, Faculty of Health Sciences, Department of Physiotherapy and Rehabilitation.

Brief summary: The ability of humans to maintain spatial orientation and balance control relies on accurate and complete sensory information. This study aims to investigate the effects of different sensory conditions on the sway index (balance). Adults with normal hearing, vision, and balance abilities will perform the Modified Clinical Test of Sensory Interaction on Balance (mCTSIB), a test from the Biodex Balance System, under varying sensory conditions. The first sensory condition involves situations where the cursor indicating the individual's center of gravity on the device is either visible or hidden. The second condition examines whether the eyes-closed state during the test is achieved through voluntary eye closure or by external equipment (e.g., goggles or eye patches). The values obtained will allow comparisons of the effects of different sensory conditions on the sway index. The study will be conducted between January 2025 and March 2025 at the Bezmialem Vakıf University Cardiac Physiotherapy and Rehabilitation Education and Research Laboratory with healthy young adults. Participants will be selected voluntarily, and the assessments will be conducted in compliance with the guidelines of the Declaration of Helsinki.


Eligibility criteria: Inclusion Criteria:

* Being between the ages of 18 and 45.
* Providing informed consent to participate in the study after receiving detailed information about the research.

Exclusion Criteria:

* Having visual or hearing impairments.
* Presence of musculoskeletal, neurological, or orthopaedic conditions (e.g., lower extremity alignment disorders, excessive anteversion, severe pes planus) that could affect the study results.
* Having mental or physical problems severe enough to impair communication.
* Participation in any rehabilitation program within the past six months.

Primary outcomes:
measure: Modified Clinical Test of Sensory Interaction on Balance (mCTSIB)
timeFrame: "From January 2025 to February 2025
measure: Assessment Form
timeFrame: "From January 2025 to February 2025
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Bezmialem Vakif University
Study officials:
References:
Clinical trial NCT04723797: The Effect of a Physical Activity Program on Burnout Risk Among Secondary School Teachers
Official title: The Effect of a Physical Activity Program on Burnout Risk Among Secondary School: a Randomised Controlled Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Burnout Risk
Physical Activity
Lead sponsor: Vrije Universiteit Brussel
Sponsor class: OTHER
First posted: 2021-01-26
Enrollment: 70
Sex: ALL
Minimum age (years): 21
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomized control trial with a control group, a moderate-intensity intervention group, and a high-intensity intervention group
Primary purpose: PREVENTION

Brief summary: The purpose of this study is to assess the effect of a 6 weeks physical activity program on burnout risk in secondary school teachers. Also, the difference between the effects of moderate en vigorous-intensity physical activity will be investigated.

Detailed description: Given the increased risk of burnout among secondary school teachers, effective interventions are needed. Physical activity may play a big role in preventing and/or reducing burnout. Therefore the purpose of this research is to investigate the effect of physical activity on the risk of burnout in secondary school teachers. The participants in the intervention group will be asked to perform a specific physical activity program (including running and/or cycling at a moderate or vigorous intensity) for 6 weeks. The control group will be asked to keep their lifestyle as it was prior to the study. To assess the effect of this activity program, the participants will have to fill in a questionnaire at three time points. Lastly, the participants have to fill in an activity diary every day, enabling to assess intervention adherence.

Eligibility criteria: Inclusion Criteria:

* Participants who are not meeting the guidelines for physical activity.
* Participants who are willing to run or cycle.

Exclusion Criteria:

* Participants who are not speaking the Dutch language.
* Participants unable or unwilling to give informed consent.
* Participants who are not able to be physically active, due to injuries, physical disabilities, etc.
* Participants who already met the guidelines for physical activity.
* Participants who are following a diet.
* Participants who have been following psychological treatment in the past 6 months.

Primary outcomes:
measure: Burnout risk
timeFrame: 9 weeks
measure: Recovery need
timeFrame: 9 weeks
Secondary outcomes:
measure: School and teaching subjects
timeFrame: 9 weeks
measure: Rate of perceived exertion
timeFrame: 9 weeks
Other outcomes:
Locations:
city: Brussel
country: Belgium
facility: Vrije Universiteit Brussel
Study officials:
References:
Clinical trial NCT01723397: Effect of Nasaleze on Nasal Challenge With Allergen
Official title: Effect of Nasaleze on the Early Reaction to Nasal Challenge With Allergen
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: NA
Conditions: Allergic Rhinitis
Lead sponsor: University of Chicago
Sponsor class: OTHER
First posted: 2012-11-07
Enrollment: 14
Sex: ALL
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The objectives of this protocol are:

1. to confirm the inhibitory effect of Nasaleze on the immediate response to nasal challenge with antigen, and
2. to show that inhibition of the immediate response to nasal challenge with antigen by Nasaleze inhibits subsequent inflammatory events.


Eligibility criteria: Inclusion Criteria

1. Males and females between 18 and 45 years of age.
2. History of grass and/or ragweed allergic rhinitis.
3. Positive skin test to grass and/or ragweed antigen.
4. Positive response to screening nasal challenge.

Exclusion Criteria:

1. Physical signs or symptoms suggestive of renal, hepatic or cardiovascular disease.
2. Pregnant or lactating women.
3. Upper respiratory infection within 14 days of study start.
4. FEV1\<80% of predicted at screening for subjects with history of mild asthma.

Primary outcomes:
measure: Change in Total Nasal Symptom Score After Nasal Challenge With Allergen Versus Diluent
timeFrame: Day 2 after one week pretreatment with Nasaleze or placebo.
Secondary outcomes:
Other outcomes:
Locations:
city: Chicago
country: United States
facility: University of Chicago
state: Illinois
Study officials:
affiliation: University of Chicago
name: Robert M Naclerio, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03279497: Health Game Intervention to Promote the Physical Activity of Early Adolescents
Official title: Health Game Intervention to Promote the Physical Activity of Early Adolescents
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Physical Activity
Health Behavior
Lead sponsor: University of Turku
Sponsor class: OTHER
First posted: 2017-09-12
Enrollment: 180
Sex: ALL
Minimum age (years): 10
Maximum age (years): 13
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: The study evaluates the effectiveness of the game-intervention in promotion of physical activity self-efficacy and physical activity behavior among early adolescents (10-13 year olds). Half of the study participants will receive the game-intervention and half of the study participants will receive a commercially available sport and fitness application for running, cycling and every-day training.

Detailed description: The study evaluates the effectiveness of the game-intervention in promotion of physical activity self-efficacy and physical activity behavior among early 10 to 13 years old adolescents. Participants allocated to the Health game intervention group will use a game called Movenator, during a four week intervention and participants allocated to the Sport and fitness-intervention group will use a commercially available Sport and fitness application for running, cycling and every-day training, during a four week intervention period.

Eligibility criteria: Inclusion Criteria:

* Goes to school at 4th, 5th or 6th grade
* Understands and can communicate either in Finnish
* Has daily access to a smart phone (Android) during free time

Exclusion Criteria:

* Physical activity impairments

Primary outcomes:
measure: Change in Physical activity behavior
timeFrame: at baseline during one week period and at 4 weeks during one week period
Secondary outcomes:
measure: Change in Physical activity self-efficacy
timeFrame: At baseline and at 4 weeks
measure: Actual use of the intervention
timeFrame: During the four week intervention
measure: Usability of the intervention
timeFrame: At 4 weeks
Other outcomes:
Locations:
city: Turku
country: Finland
facility: Primary schools (n=2)
state: Southwest Finland
Study officials:
affiliation: University of Turku
name: Anni Pakarinen, MHSc
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04366297: Intravascular Access of COVID-19 Patient Under Personal Protective Equipment
Official title: Intraosseous Versus Intravenous Access During COVID-19 Patients Performed by Paramedics Wearing Level C Personal Protective Equipment. A Multi-center Prospective Randomized Crossover Single-blinded Simulation Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cardiac Arrest
Emergencies
Keywords: intravascular access
COVID-19
personal protective equipment
medical simulation
Lead sponsor: Lazarski University
Sponsor class: OTHER
Collaborators: name: Poznan University of Medical Sciences
name: Medical University of Bialystok
name: Wroclaw Medical University
First posted: 2020-04-28
Enrollment: 41
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: The current COVID-19 pandemic, this is especially since the transmission of SARS-CoV-2 is thought to occur mainly through respiratory droplets generated by coughing and sneezing, by direct contact with contaminated surfaces and because in a large number of patients COVID-19 disease may be asymptomatic. As recommended by the CDC medical personnel should be equipped with full personal protective equipment (PPE) for AGP in contact with suspected/confirmed COVID-19 patient. Therefore, it is reasonable to search for the most effective methods of intravascular access in those conditions.


Eligibility criteria: Inclusion Criteria:

* paramedic
* consent voluntary participation in the study
* none experience in resuscitation with personal protective equipment

Exclusion Criteria:

* refusal to participate in the study

Primary outcomes:
measure: successful rate of first intravascular access attempt
timeFrame: 1 day
Secondary outcomes:
measure: time to successful access
timeFrame: 1 day
measure: number of attempts to successful access
timeFrame: 1 day
measure: time to infusion
timeFrame: 1 day
measure: complication rates
timeFrame: 1 day
measure: ease of use
timeFrame: 1 day
measure: Preferred intravascular access method
timeFrame: 1 day
Other outcomes:
Locations:
city: Warsaw
country: Poland
facility: Lazarski Univeristy
Study officials:
affiliation: Wroclaw Medical University
name: Jacek Smereka, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Smereka J, Szarpak L, Filipiak KJ, Jaguszewski M, Ladny JR. Which intravascular access should we use in patients with suspected/confirmed COVID-19? Resuscitation. 2020 Jun;151:8-9. doi: 10.1016/j.resuscitation.2020.04.014. Epub 2020 Apr 15. No abstract available.
Clinical trial NCT02689297: Three Different Oral Hygiene Regimes on Three Volatile Sulfur Compounds
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Halitosis
Lead sponsor: Tokyo Medical and Dental University
Sponsor class: OTHER
First posted: 2016-02-23
Enrollment: 30
Sex: MALE
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: The purpose of the study is to evaluate the effect of various oral hygiene regimes on three volatile sulfur compounds.

Detailed description: Thirty male monk volunteers who matched with the including criteria were divided randomly into two groups. Both groups were practiced to brush their teeth with scrubbing method for one week. Then, each group were instructed to do different additional protocol regimen- group A have to do mouth washing and tooth brushing and group B have to practice tongue cleaning addition to tooth brushing for three weeks. At the fifth week, both groups were instructed to practice tooth brushing, mouth washing and tongue cleaning. Three different volatile sulfur compounds were measured by oral chroma. Tongue characteristics, oral examination were checked as the outcomes of this study.

Eligibility criteria: Inclusion Criteria:

* Clinical diagnosis of oral malodor
* No systemic diseases and no severe dental diseases
* At least 20 functional teeth

Exclusion Criteria:

* Risky oral habit (smoking and betel quid chewing)
* Current use of antibiotics or any drugs
* Current use of any kind of mouthwash

Primary outcomes:
measure: Three different volatile sulfur compounds
timeFrame: up to 5weeks
Secondary outcomes:
measure: Oral Health examination
timeFrame: up to 5weeks
measure: Tongue coating characteristics
timeFrame: up to 5weeks
measure: Number of teeth with bleeding on probing
timeFrame: up to 5weeks
measure: Plaque index score
timeFrame: up to 5weeks
Other outcomes:
Locations:
Study officials:
References: