Clinical trial NCT03387371: Laser Assisted Nonsurgical Periodontal Treatment
Official title: Clinical and Microbiologic Effects of Nonsurgical Periodontal Treatment Combined With an Erbium: Yttrium Aluminium Garnet Laser
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Chronic Periodontitis
Keywords: chronic periodontitis, laser
Lead sponsor: Bezmialem Vakif University
Sponsor class: OTHER
First posted: 2018-01-02
Enrollment: 38
Sex: ALL
Minimum age (years): 28
Maximum age (years): 58
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Periodontitis is a chronic inflammatory disease caused by mixed infections with the subgingival microbiota being organized as a biofilm that, if untreated, may result in breakdown of the periodontal tissues in susceptible individuals. Evidence from intervention studies shows that mechanical root debridement significantly improves periodontal health by halting the progression of periodontal tissue breakdown. In order to improve effectiveness and efficacy of the removal of the subgingival biofilm, Er:YAG laser therapy has recently been recommended as an alternative to conventional scaling procedures.


Eligibility criteria: Inclusion Criteria:

Greater than 25 years, Clinical diagnosis of moderate to advanced chronic periodontitis, Pocket depth ≥ 5 mm or clinic attachment level ≥ 4 mm at least in two interproximal areas (not on the same tooth), Along with very good oral hygiene scores (GI≤1and PI≤1), At least 4 teeth in each quadrant, Teeth with subgingival plaque sample is collected has no restoration or prothesis

Exclusion Criteria:

Periodontal treatment ( root planning or surgical periodontal treatment) had done before, Systemic disease that could influence the outcome of periodontal therapy, Prophylaxis regime mandatory during periodontal treatment, Use of any drug that could influence the outcome of periodontal therapy, Use of antibiotics within the last 3 months, Use of anti-inflammatory drugs within the last 3 months, Use of removable prothesis Pregnancy, lactation or use of hormone contraceptives, Smoking

Primary outcomes:
measure: Probing Pocket Depth 3
timeFrame: 3. month
measure: Clinic Attachment Level 3
timeFrame: 3. month
measure: Subgingival Plak Sample 1
timeFrame: 1. month
measure: Probing Pocket Depth 6
timeFrame: 6. month
measure: Clinic Attachment Level 6
timeFrame: 6. month
measure: Subgingival Plak Sample 3
timeFrame: 3. month
measure: Subgingival Plak Sample 6
timeFrame: 6. month
Secondary outcomes:
measure: Bleeding On Probing 3
timeFrame: 3. month
measure: Bleeding On Probing 6
timeFrame: 6. month
measure: Plak Index 3
timeFrame: 3. month
measure: Plak Index 6
timeFrame: 6. month
Other outcomes:
Locations:
Study officials:
References:
citation: Zengin Celik T, Saglam E, Ercan C, Akbas F, Nazaroglu K, Tunali M. Clinical and Microbiological Effects of the Use of Erbium: Yttrium-Aluminum-Garnet Laser on Chronic Periodontitis in Addition to Nonsurgical Periodontal Treatment: A Randomized Clinical Trial-6 Months Follow-Up. Photobiomodul Photomed Laser Surg. 2019 Mar;37(3):182-190. doi: 10.1089/photob.2018.4510. Epub 2019 Feb 21.