Clinical trial NCT05003297: Neutrophil to Lymphocyte Ratio (NLR) and Platelet to Lymphocyte Ratio (PLR) as an Inflammatory Markers to Predict Length of Hospital Stay After Total Laparoscopic Hysterectomy (TLH) for Benign Indications
Official title: Can Neutrophil to Lymphocyte Ratio (NLR) and Platelet to Lymphocyte Ratio (PLR) be Used as Inflammatory Markers to Predict Length of Hospital Stay After Total Laparoscopic Hysterectomy (TLH) for Benign Indications?
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Inflammation
Hospital Stay
Total Laparoscopic Hysterectomy
Lead sponsor: Gaziosmanpasa Research and Education Hospital
Sponsor class: OTHER_GOV
First posted: 2021-08-12
Enrollment: 150
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients whom have undergone TLH without any postoperative surgical complications

Brief summary: Due to short hospital stay, rapid return to work, less pain, and good cosmetic results, laparoscopic hysterectomy ( LH) has substantially increased the era of hysterectomy procedures especially for the last two decades. The main reason for this is probably that LH leads to fewer inflammatory responses when compared to open abdominal hysterectomy. Although the inflammatory response is supposed to be lower with total laparoscopic hysteroscopy (TLH), unpredictable inflammatory response as a result of the operation has been still unenlightened and it can be associated with hospital stay.

Detailed description: IInflammatory response after surgery is an ordinary outcome which ends up with tissue repair. The increase in neutrophil levels accompanied with a decrease in lymphocyte levels is characteristic for the inflammatory response. Therefore, neutrophil to lymphocyte ratio (NLR) comes out as a simple index of inflammation. In the literature, NLR was shown not only to be associated with surgical complications but also the length of hospital stays in certain surgeries. Another inflammatory marker index of hemogram is the platelet to lymphocyte ratio (PLR). As a result of endothelial tissue damage, platelets are gathered in the affected area. Therefore, an increase in the number of platelets is inevitable for inflammation. Hence, PLR appears to be another simple index of inflammation due to the increase of platelets and the decrease of lymphocytes. PLR has also shown to be associated with length of hospital stay in various surgeries. NLR and PLR are both newly recommended inflammatory markers to estimate the prognosis of surgical treatment in clinics. Investigations regarding NLR and PLR concerning prognosis of patients after surgeries including gynecological cancer, cardiac surgeries, and emergency surgeries are available in prior literature. Investigators aimed to investigate the possible effects of inflammatory parameters, that can be easily obtained from complete blood count in the post-operative first day of total laparoscopic hysterectomy, to the length of hospital stay in patients without any complications.

Eligibility criteria: Inclusion Criteria:

* Patients whom have undergone TLH

Exclusion Criteria:

* Ureter injury
* Bladder injury,
* Bowel injury,
* Superficial inferior mesenteric artery injury
* Vaginal cuff hematoma
* Vaginal cuff dehiscence
* Endometriosis
* Endometrial cancer
* Cervical cancer
* Chronic lymphocytic leukemia
* Behçet disease
* Electrolyte imbalance
* Thyroid disease
* Using anti-inflammatory medications
* Having severe intraabdominal adhesions

Primary outcomes:
measure: Postoperative NLR values compared in patients who were hospitalized for more than 3 days and equal to or less than 3 days.
timeFrame: 4 years
measure: Postoperative PLR values compared in patients who were hospitalized for more than 3 days and equal to or less than 3 days.
timeFrame: 4 years
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References: