louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT04811183: Pharmaceutical Consultation and Exchange Between the Pharmacy and the Hospital
Official title: Pharmaceutical Consultation and Exchange Between the Pharmacy and the Hospital
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Diabetes
Keywords: pharmaceutical consultations
adherence
Lead sponsor: Hospices Civils de Lyon
Sponsor class: OTHER
First posted: 2021-03-23
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult patient admitted in the endocrinology service for a type 2 Diabetes who has more than 5 concomitting treatments, on the way to returning home.

Brief summary: Investigators hypothesize that the implementation of a hospital pharmacy consultation and the transmission of its report to pharmacies may improve knowledge, adherence and encourage the development of pharmacist medication reviews. A before-and-after study of the implementation of pharmaceutical consultations will allow the investigators to evaluate the validity of the hypothesis.


Eligibility criteria: Inclusion Criteria:

* Adult patient admitted in the endocrinology service for a type 2 Diabetes who has more than 5 concomitant treatments
* Adult patient that is being discharged for a return home
* Good comprehension of French

Exclusion Criteria:

* Bad comprehension of French

Primary outcomes:
measure: Evolution in the knowledge about the patient's condition
timeFrame: One week
measure: Evolution in the adherence
timeFrame: One week
Secondary outcomes:
Other outcomes:
Locations:
city: Bron
country: France
facility: Hôpital Louis Pradel
Study officials:
References:
Clinical trial NCT02813083: Detection of Pathological Lymphocytes in Patients With Autoimmune Disease
Official title: Detection of Pathological Lymphocytes in Patients With Autoimmune Disease
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Arthritis, Rheumatoid
Lead sponsor: University of Minnesota
Sponsor class: OTHER
First posted: 2016-06-24
Enrollment: 129
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The investigators will enroll 155 rheumatoid arthritis patients from the University of Minnesota Rheumatology clinics.

Brief summary: This study will help the investigators design a method to detect the disease-causing immune cells in patients with rheumatoid arthritis (RA). Such methods are not currently available, but if successful, would help scientists to better understand the causes of RA.

Detailed description: The investigators are interested in learning about the immune cells in the blood that contribute to disease in patients with rheumatoid arthritis (RA). They have developed a method for identifying a specific type of immune cells that can react against normal tissues in the body.

In this study, the investigators will enroll RA patients from the University of Minnesota clinics, collect blood samples from enrolled patients, and process the blood samples to isolate DNA, RNA, serum, and blood cells. They will use the serum to detect whether specific autoantibodies (Anti-cyclic Citrullinated Peptide, or anti-CCP) are present. In cases where anti-CCP antibodies are detected, the investigators may quantify the numbers of immune cells present that contain receptors with the same anti-CCP specificity. They may also test whether the numbers of immune cells with these receptors correlate with measures of disease activity in RA patients.

Eligibility criteria: Inclusion Criteria:

* Diagnosis of rheumatoid arthritis

Exclusion Criteria:

* Use of rituximab immediately prior to visit
* Pregnancy

Primary outcomes:
measure: DAS28-ESR
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Minneapolis
country: United States
facility: University of Minnesota Department of Medicine
state: Minnesota
Study officials:
affiliation: University of Minnesota
name: Daniel Mueller, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03126383: Inflammatory Myopathies in Primary Sjögren's Syndrome
Official title: Characterization of Inflammatory Muscle Involvement in Patients With Primary Sjögren's Syndrome
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Primary Sjögren Syndrome
Lead sponsor: University Hospital, Brest
Sponsor class: OTHER
First posted: 2017-04-24
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Primary Sjögren's syndrome

Brief summary: The AMISS study will characterize the features of muscle disease in patients with primary Sjogren's syndrome (pSS).

Detailed description: Muscle disease is associated with pSS, but this association is not well defined. The AMISS study, a retrospective observational multicentric study, will recruit patients with pSS and muscle involvement in order to characterize in details the features of this association (epidemiological aspects, clinical presentation, biological, radiological and histological findings, treatments and outcomes).

Eligibility criteria: Inclusion Criteria:

* diagnosis of Primary Sjögren's syndrome according to the ACR/EULAR classification criteria
* inflammatory muscle involvement, as diagnosed by the treating physician

Exclusion Criteria:

* Diagnosis of inflammatory myopathy before the diagnosis of pSS

Primary outcomes:
measure: Proportion of patients fulfilling classification criteria for inflammatory myopathies
timeFrame: At diagnosis
Secondary outcomes:
Other outcomes:
Locations:
city: Brest
country: France
facility: CHRU de Brest
Study officials:
References:
Clinical trial NCT06658483: Hand ScleroDerma Lived Experience Scale in Individuals with Systemic Sclerosis
Official title: Investigation of the Turkish Validity and Reliability of the Hand ScleroDerma Lived Experience Scale (HAnDE Scale) Questionnaire in Individuals with Systemic Sclerosis
Study type: OBSERVATIONAL
Overall status: ENROLLING_BY_INVITATION
Conditions: Systemic Sclerosis (SSc)
Hand Function
Lead sponsor: Pamukkale University
Sponsor class: OTHER
First posted: 2024-10-26
Enrollment: 54
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: The study will include individuals aged 18 and older who are receiving treatment for Systemic Sclerosis at two university hospital in Turkey, and meet the inclusion and exclusion criteria.

Brief summary: The aim of this study was to examine the Turkish validity and reliability of the Hand scleroDerma lived Experience Scale (HAnDE Scale) Questionnaire in individuals with SSc.


Eligibility criteria: Inclusion Criteria:

* Being diagnosed with Systemic Sclerosis by a rheumatologist
* Being 18 years of age or older,

Exclusion Criteria:

* Presence of neurological disease
* Presence of any orthopedic problem that will affect functionality
* Presence of orthopedic surgery history
* Inability to speak or understand Turkish fluently.
* Presence of psychiatric disease that will affect cooperation.
* Severe neurological disease that will affect hand functions (peripheral nerve lesion, trauma, operation, cerebrovascular accident).
* Heart failure and lung pathology that will affect daily living activities.

Primary outcomes:
measure: Hand ScleroDerma Lived Experience Scale (HAnDE Scale) Questionnaire
timeFrame: Evaluations started immediately after receiving ethics committee approval and will be completed within 6 months, which is the study period.
Secondary outcomes:
measure: Hand Mobility in Scleroderma Test
timeFrame: Evaluations started immediately after receiving ethics committee approval and will be completed within 6 months, which is the study period.
measure: Scleroderma Skin Involvement: Patient-Reported Outcomes
timeFrame: Evaluations started immediately after receiving ethics committee approval and will be completed within 6 months, which is the study period.
measure: Modified Rodnan Skin Thickness Score
timeFrame: Evaluations started immediately after receiving ethics committee approval and will be completed within 6 months, which is the study period.
measure: Scleroderma Health Assessment Questionnaire
timeFrame: Evaluations started immediately after receiving ethics committee approval and will be completed within 6 months, which is the study period.
Other outcomes:
Locations:
city: Denizli
country: Turkey
facility: Pamukkale University
city: Malatya
country: Turkey
facility: Inonu University
Study officials:
References:
Clinical trial NCT06683183: Ability of the Polar Wearables to Detect Fetal Heart Rate - Pilot Clinical Study
Official title: Ability of the Polar Wearables to Detect Fetal Heart Rate - Pilot Clinical Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Fetal Heart Rate Tracing
Lead sponsor: University of Turku
Sponsor class: OTHER
Collaborators: name: Polar Electro Oy
First posted: 2024-11-12
Enrollment: 11
Sex: FEMALE
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Pregnant women recruited for the study are registered at the hospital ward for pregnant women. The data collection will be conducted after the routine fetal monitoring and will not affect normal monitoring practices.

Brief summary: The aim of this clinical pilot study is

1. to evaluate the ability of the wearables to detect fetal heart rate
2. to evaluate the ability to distinguish the fetal ECG from the ECG of the mother

The participating pregnant women will wear the Polar wearables (chest band, smart watch, arm band) for 15 minutes during of which, the data will be collected with all three wearables and patient monitor (reference device). The data from the wearables will be compared with the patient monitor data referred as golden standard. Background information will be collected with questionnaires from the participants. The data collection will be conducted in hospital environment.


Eligibility criteria: Inclusion Criteria:

* duration of pregnancy at least 29+0 weeks
* single pregnancy
* age at least 18 years
* ability to participate in Finnish. No exclusion criteria

Primary outcomes:
measure: Fetal heart rate
timeFrame: 15 minute data collection
Secondary outcomes:
Other outcomes:
Locations:
city: Turku
country: Finland
facility: Turku University Hospital
Study officials:
References:
Clinical trial NCT01775683: Can we Predict Chronic Homelessness?
Official title: A Case-control Study to Determine Whether a Screening Measure of Executive Dysfunction, the Quick EXIT, is Predictive of Chronic Homelessness
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Cognitive Impairment
Keywords: homelessness
Lead sponsor: Ottawa Hospital Research Institute
Sponsor class: OTHER
First posted: 2013-01-25
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Homeless men and women, greater or equal to 18 years, English-speaking, in Ottawa, ON, Canada

Brief summary: Homeless men and women suffer more illness and sooner death compared to housed people. Among the homeless, there is a group that suffers more illness than others. This group is usually homeless for several months, makes up a smaller proportion of homeless people and uses more resources from emergency shelters than other homeless people. Some have asked if a difference in thinking skills explains how people who are homeless for a long time need more help in getting and keeping housing compared to other homeless persons.

In this study, thinking skills that help a person plan and make decisions will be screened among those who have been homeless for a long time and those who were homeless for a short time. If there is a difference, then screening may change how future homeless people get the help they need.


Eligibility criteria: Inclusion Criteria:

* Men and women, greater than or equal to 18 years old, English speaking
* Group A: currently homeless and/or housed in an emergency shelter or housing facility for chronically homeless individuals ≥ 6 months
* Group B: not homeless ≥4 times in the last 3 years and currently living in stable housing ≥ 6 months and in the last 3 years, has been homeless ≤ 1 month

Exclusion Criteria:

At the time of testing, individuals with the following characteristics will be excluded:

1. Altered mental status (determined by Nurse Coordinator through participant response to questions regarding orientation to person, place and season - score of at least 2/3 is considered intact mental status).
2. Present intoxication (determined by Nurse Coordinator through participant evaluation of odour, either alcohol or non-beverage alcohol).
3. Currently violent or aggressive towards testers (determined by Nurse Coordinator)

Primary outcomes:
measure: The Quick EXIT score
timeFrame: Within 2 weeks of recruitment
Secondary outcomes:
measure: The Colour Trails test score
timeFrame: Within 2 weeks of recruitment
Other outcomes:
Locations:
city: Ottawa
country: Canada
facility: The Ottawa Hospital Rehabilitation Centre
state: Ontario
Study officials:
affiliation: The Ottawa Hospital Rehabilitation Centre
name: Claire Vayalumkal, BASc, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03614897: Prevention of Falls in the Elderly Population
Official title: Prevention of Falls in the Elderly Population
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Accidental Falls
Lead sponsor: The Guthrie Clinic
Sponsor class: OTHER
First posted: 2018-08-03
Enrollment: 43
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: An educational intervention will be utilized to improve care following guidelines for treating individuals at risk of falling. A survey will be administered to providers pre and post education.


Eligibility criteria: Inclusion Criteria:

* Primary care providers in Family Medicine and Internal Medicine

Exclusion Criteria:

* Providers in outlying clinics

Primary outcomes:
measure: Change in Mean Survey Score for Providers' Self-reported View on Vitamin Deficiency as a Cause of Falls
timeFrame: 1year
Secondary outcomes:
Other outcomes:
Locations:
city: Sayre
country: United States
facility: Guthrie Medical Group
state: Pennsylvania
Study officials:
affiliation: The Guthrie Clinic
name: Alicia Harbison, DO
role: PRINCIPAL_INVESTIGATOR
affiliation: The Guthrie Clinic
name: Sheela Prabhu, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Harbison AJ, Prabhu S. Causation and Treatment Algorithms for Elderly Patients who have Fallen in the Twin Tiers. Cureus. 2019 Dec 30;11(12):e6513. doi: 10.7759/cureus.6513.
Clinical trial NCT04370197: Covid-19 Epidemic on Acute Stroke Management
Official title: Impact of th Covid-19 Epidemic on Acute Stroke Management
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Stroke, Acute
Keywords: STROKE , Acute
Covid-19
SARS-COV-2
Mechanical thrombectomy
Thrombolysis
Lead sponsor: University Hospital, Strasbourg, France
Sponsor class: OTHER
First posted: 2020-04-30
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult stroke patients

Brief summary: The Covid-19 pandemic is a pandemic of an emerging infectious disease, coronavirus 2019 (Covid-19), caused by the coronavirus SARS-CoV-2. It appears in November 2019 in the city of Wuhan, China, and spreads worldwide from February 2020. The first cases of infection in France were confirmed on 24 January 2020. As of April 14, 103,573 cases of infection were confirmed, 32,292 hospitalized cases, including 6,730 in intensive care, with 15,729 deaths recorded1. The most affected regions are Ile de France and the Grand Est (in particular the Haut-Rhin department). Containment of the entire French population was introduced on 17 March, with the aim of reducing the spread of the virus and relieving the burden on the health system, particularly the intensive care units.

This unprecedented health crisis, as well as the social containment measures in themselves, has repercussions on other acute medical pthologies, not directly related to the viral infection. It appears that the number of patients treated for acute stroke has suddenly declined since the beginning of the epidemic.

However, it is not clear whether it is the incidence of stroke that has declined or simply the proportion of patients presenting within the time frame that allows for treatment in the acute phase (by thrombolysis or thrombectomy).


Eligibility criteria: Inclusion Criteria:

* Adult patient
* Stroke Patients
* Patient who agreed to participate in this study

Exclusion Criteria:

- Refusal to participate in this study

Primary outcomes:
measure: Study of the effect of pandemic covid-19 on the management of stroke patients
timeFrame: 1 month
Secondary outcomes:
Other outcomes:
Locations:
city: Strasbourg
country: France
facility: Service de Neuroradiologie Interventionnelle
Study officials:
References:
Clinical trial NCT01042197: The Relation Between Vitamin D Production and UVB Exposed Body Surface Area
Official title: Interdependence Between Body Surface Area and UVB Dose in Vitamin D Production: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Vitamin D Status
Keywords: Vitamin D
UVB
Dose-Response
Body surface area
Lead sponsor: Bispebjerg Hospital
Sponsor class: OTHER
Collaborators: name: Vejle Hospital
First posted: 2010-01-05
Enrollment: 92
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of this study is to investigate the relation between vitamin D production after UVB and exposed body surface areas with different UVB doses.

Detailed description: Vitamin D deficiency is very common. Rachitis, osteoporosis, cancer, sclerosis as well as cardiovascular diseases are related to vitamin D deficiency. Elderly people, immigrants as well as patients with malabsorption diseases often have vitamin D deficiency. 90-95 % of the total vitamin D requirements are obtained from the ultraviolet (UV) radiation of the skin.In spite of the risk of skin-cancer, treatment with sunlight radiation is often recommended against vitamin D deficiency. This fact has raised a scientific debate, where concern has been expressed with regard to the risk of skin-cancer. This dilemma should also be examined as no human studies are available on the vitamin D production in the skin after UV-radiation showing the frequency and dose necessary for sufficient production of vitamin D. The lowest exposure frequency, the smallest body surface area and the lowest UV dose should therefore be established to be exposed in order to minimize the risk of skin-cancer by unnecessary UV-radiation. The purpose of the project is therefore to clarify which factors there are of importance for the production of vitamin D in the skin after UVB radiation.

Eligibility criteria: Inclusion Criteria:

* Healthy individuals between 18 - 65 years of age.
* Avoidance of sun bed exposure
* Not Holidaying south of 45 degrees latitude 3 months before
* Avoiding vitamin D supplementation during and two months before

Exclusion Criteria:

* Illness as well as age above 65 years.
* Skin diseases
* Psychiatric diseases
* Drug addiction
* Intake of photosensitive medicine.
* Intake of cholesterol-lowering medicine.
* Pregnancy

Primary outcomes:
measure: Vitamin D (nmol/l) measured in a blood sample to define just how much sun exposure is necessary to obtain a sufficient vitamin D production.
timeFrame: Before and 2 days after the last UVB session.
Secondary outcomes:
Other outcomes:
Locations:
city: Copenhagen Nv
country: Denmark
facility: Bispebjerg Hospital, Department of Dermatology D92, Bispebjerg Bakke 23,
state: Copenhagen
Study officials:
affiliation: Bispebjerg Hospital
name: Hans Christian Wulf, Full Prof.
role: STUDY_CHAIR
References:
Clinical trial NCT00678197: Philippine Child Health and Policy Experiment
Official title: Philippine Child Health and Policy Experiment
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Childhood Illness
Keywords: Quality of care
Access to care
Health Outcomes
Lead sponsor: University of California, San Francisco
Sponsor class: OTHER
First posted: 2008-05-15
Sex: ALL
Minimum age (years): 6
Maximum age (years): 5
Standard ages: CHILD
Accepts healthy volunteers: yes
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The long-term consequences of poverty on child health, including cognitive development, are one of the world's great tragedies. In the Philippines, diarrhea, acute lower respiratory infections, and the attendant problems of malnutrition, are the leading causes of childhood illness. The Philippine government plans to launch a broad national Health Sector Reform Agenda (HSRA) that will address the problems of poverty and illness in children. The introduction of these reforms provides an exceptional opportunity to conduct a social experiment. Four institutions, already involved in the design and implementation of the HSRA, plus leading experts in international health, government, and health measurement will collaborate on this project to collect longitudinal data and measure the impact of HSRA reforms on child health outcomes in a population. We will measure the health impacts of two experimental interventions: (1) expansion of health insurance coverage, and (2) capitation of providers. Our research will measure the impact of health reforms on the physical and cognitive health outcomes of children age 0-4. We will use a block design of 21 sites throughout the Philippines: seven for each of the two interventions, and seven matched controls. We will measure the quality of clinical practice using vignettes and will measure health outcomes using objective clinical tests. We will also use an advanced sampling strategy and panel data to link clinical practice with population health outcomes. This unparalleled research opportunity will yield significant insights about specific, unanswered questions of tremendous importance: Does health care serve as a social intervention that ameliorates the effects of morbidity and malnutrition on cognitive development? How effective are government policies at creating incentives to improve the quality of clinical practice? Do financial and organizational policies actually lead to better health and developmental outcomes? The results from this study will provide insights into the linkages between increased access, high quality care, and health outcomes in children.


Eligibility criteria: Inclusion Criteria:

* Children presenting to participating hospitals

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Manila
country: Philippines
Study officials:
References:
citation: Peabody JW, Florentino J, Shimkhada R, Solon O, Quimbo S. Quality variation and its impact on costs and satisfaction: evidence from the QIDS study. Med Care. 2010 Jan;48(1):25-30. doi: 10.1097/MLR.0b013e3181bd47b2.