louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05891405: Cardiac Surgery for Babies Less Than 5 kg:Risk Factors for Morbidity and Mortality
Official title: Cardiac Surgery for Babies Less Than 5 kg:Risk Factors for Morbidity and Mortality
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Cardiac Surgery in Neonates
Lead sponsor: Sohag University
Sponsor class: OTHER
First posted: 2023-06-06
Enrollment: 100
Sex: ALL
Minimum age (years): 1
Maximum age (years): 2
Standard ages: CHILD
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Neonates with congenital heart diseases undergoing surgery for complete or partial treatment with body weight less than 5 kg at time of surgery

Brief summary: Cardiac surgery in babies less than 6 kg of weight is a complex and high-risk procedure. Despite advances in medical technology, mortality and morbidity rates remain high. This study seeks to identify risk factors associated with mortality and morbidity in this population


Eligibility criteria: Inclusion Criteria:

* neonates undergoing surgery for congenital heart diseases

Exclusion Criteria:

* larger body weights than 5 kg

Primary outcomes:
measure: Mortality
timeFrame: 1 month postoperative
Secondary outcomes:
measure: Morbidity
timeFrame: 1 month postoperative
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT03749005: Impact of Three-dimensional Visualization on Operation Strategy and Complications for Pancreatic Cancer
Official title: Impact of Three-dimensional Visualization on Operation Strategy and Complications for Pancreatic Cancer
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Pancreatic Cancer
Keywords: Pancreatic Cancer
Three-dimensional Visualization
Lead sponsor: Zhujiang Hospital
Sponsor class: OTHER
First posted: 2018-11-21
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The patients with Pancreatic Cancer.

Brief summary: The aim of the multi-centre study is to evaluate correctly the impact of three dimensional visualization on operation strategy and complications for Pancreatic Cancer.

Detailed description: Because of the complexity of Pancreatic Cancer, the limitations of 2D images of CT/MRI and the uncertainty of surgeons'experience, it is difficult for the surgeons to diagnosis and assess the operation strategy accurately based on traditional 2D imaging(CT/MRI).The aim of the multi-centre study is to evaluate correctly the impact of three-dimensional visualization on operation strategy and complications for Pancreatic Cancer.

Eligibility criteria: Inclusion Criteria:

1.18 years≤ Age ≤70 years 2.Compling with the diagnosis criteria of Pancreatic Cancer. 3.Primary Pancreatic Cancer without metastasis. 4.The patients are volunteered for the study.

Exclusion Criteria:

1. Patients with mental illness.
2. Patients can't tolerate the operation owe to a variety of basic diseases (such as severe cardiopulmonary insufficiency, renal insufficiency, cachexia and blood system diseases, etc.)
3. The patients refused to take part in the study.
4. There are other co-existed malignant tumors.

Primary outcomes:
measure: Impact on operation strategy of three dimensional visualization technique
timeFrame: 30 days
Secondary outcomes:
measure: Impact on complication of three dimensional visualization technique
timeFrame: 30 days
measure: 1-year disease free survival rate
timeFrame: 12 months
Other outcomes:
Locations:
city: Guangzhou
country: China
facility: Zhujiang Hospital of The Southern Medical University
state: Guangdong
Study officials:
References:
Clinical trial NCT02948205: Analysis of TU-LESS by 3D Laparoscopy in the Treatment of Infertility
Official title: Analysis of Trans-umbilical Laparoendoscopic Single-site Surgery by 3D Laparoscopy in the Treatment of Infertility
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Infertility, Female
Keywords: Infertility, TU-LESS, 3D laparoscopy
Lead sponsor: Shanghai First Maternity and Infant Hospital
Sponsor class: OTHER
First posted: 2016-10-28
Enrollment: 500
Sex: FEMALE
Minimum age (years): 25
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study intends to carry out a prospective, randomized controlled trial to compare the trans-umbilical laparoendoscopic single-site surgery by 3D laparoscopy with normal laparoendoscopic surgery in the treatment of infertility patient, so as to further clarify the safety and curative effect of TU-LESS by 3D laparoscopy and provide evidence-based basis for its application in infertility population.


Eligibility criteria: Inclusion Criteria:

1. Patients are younger than 36 and older than 24.
2. Clearly diagnosed with female Infertility.
3. Infertility within 1 to 10 years.
4. informed consent form signed

Exclusion Criteria:

1. Over the age of 35.
2. Indefinite diagnosis.
3. With severe medical problems (severe liver disease, kidney disease, respiratory diseases, heart disease or uncontrolled diabetes, epilepsy, etc., dysfunction of important organs).
4. abdominal surgery history
5. Unwilling to comply with the research plan.

Primary outcomes:
measure: pain score
timeFrame: in 24 hours after surgery
measure: pregnancy rate
timeFrame: 6 months after surgery
Secondary outcomes:
measure: Operation time
timeFrame: intraoperative
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT06451705: Pecs Block vs Local Infiltration in Mastectomy
Official title: Comparison Between Pectoral Nerve Block II and Local Anesthesia Infiltration of Isobaric Bupivacaine 0.25% 50 MG on Neutrophil-Lymphocyte Ratio, Interleukin-6 Levels, Pain Intensity, and Post-surgical Opioid Requirements in Modified Radical Mastectomy Patients
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pain, Postoperative
Keywords: postoperative pain
modified radical mastectomy
peripheral nerve block
local infiltration anesthesia
pectoralis nerve block
Lead sponsor: Hasanuddin University
Sponsor class: OTHER
First posted: 2024-06-11
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: single-blind randomized trial
Primary purpose: TREATMENT

Brief summary: Studied the comparison between PECS II block and LIA on pain intensity, opioid requirements, RNL, and postoperative IL-6 levels in MRM patients.


Eligibility criteria: Inclusion Criteria:

1. Age: 18-60 years old.
2. Body weight (BW): 50-70 kg.
3. Height (TB): 150-170 cm.
4. Body mass index (BMI): 18.5-29.9 kg/m2.
5. American Society of Anesthesiologists physical status (ASA PS) class I-II.
6. Patients undergoing elective MRM surgery under general anesthesia.

Exclusion Criteria:

1. Patients with contraindications to PECS II block.
2. Patients with contraindications to LIA.
3. Patients with coagulation disorders or receiving anticoagulant therapy.
4. Patients with a history of chronic pain.
5. Patients with a history of allergy to study materials.
6. Patients with a history of previous breast surgery.
7. Patient refuses to participate in the study.

Primary outcomes:
measure: Concentration of Plasma Interleukin-6
timeFrame: 1 hour before surgery, 2 hour after surgery, 12 hour after surgery
measure: Neutrophil-lymphocyte ratio
timeFrame: 1 hour before surgery, 2 hour after surgery, 12 hour after surgery
measure: Pain intensity (Using Numeric Rating Scale)
timeFrame: hour 0, 2, 4, 6, 12, 24
measure: Rescue opioid requirement
timeFrame: Within 24 hours after surgery
Secondary outcomes:
measure: Demographic baseline data
timeFrame: baseline (before the surgery)
measure: Time until first rescue opioid requirement
timeFrame: Within 24 hours after surgery
measure: Nausea and vomiting
timeFrame: Within 24 hours after surgery
Other outcomes:
Locations:
city: Makasar
country: Indonesia
facility: RSUP dr. Wahidin Sudirohusodo
state: Sulawesi Selatan
Study officials:
References:
Clinical trial NCT04292405: Accuracy of Cardiac Acoustic Biomarkers Recorded by the Wearable Cardioverter Defibrillator
Official title: Accuracy of Cardiac Acoustic Biomarkers Recorded by the Wearable Cardioverter Defibrillator
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Heart Failure
Lead sponsor: Zoll Medical Corporation
Sponsor class: INDUSTRY
First posted: 2020-03-03
Enrollment: 60
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Primary Care, Heart Failure, and Cardiology

Brief summary: Evaluate data accuracy of cardiac acoustic biomarkers (CABs) recorded by the Wearable Cardioverter Defibrillator (WCD) as compared to the AUDICOR AM acoustic cardiography recorder.

Detailed description: Single arm, prospective, non significant risk device study to evaluate data accuracy of cardiac acoustic biomarkers (CABs) recorded by the Wearable Cardioverter Defibrillator (WCD) compared with the CABs data simultaneously recorded by an acoustic cardiography recorder, the AUDICOR AM device.

Eligibility criteria: Inclusion Criteria:

* 18 years of age or older
* heart failure or a history of heart failure
* ischemic or non-ischemic cardiomyopathy
* ejection Fraction less than or equal to 40% as measured within the last 6 months

Exclusion Criteria:

* implanted left ventricular assist device
* pacemaker dependency
* currently hospitalized
* atrial fibrillation on their last ECG or having an irregularly irregular pulse

Primary outcomes:
measure: CABs comparison
timeFrame: 2 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Rochester
country: United States
facility: MAYO Clinic
state: Minnesota
Study officials:
affiliation: Director, Clinical Operations, ZOLL
name: Mike Osz
role: STUDY_DIRECTOR
References:
Clinical trial NCT05567705: The Attitudes of Doctors Working in the Surgical Clinic of Patient Blood Management
Official title: The Attitudes of Doctors Working in the Surgical Clinic of a University Hospital for Patient Blood Management: a Survey-based Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: A Survey-based Study
Lead sponsor: Zonguldak Bulent Ecevit University
Sponsor class: OTHER
First posted: 2022-10-05
Enrollment: 91
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Being a doctor working in the surgical clinics of the university hospital

Brief summary: The attitudes of doctors working in the surgical clinic of a university hospital for patient blood management: a survey-based study


Eligibility criteria: Inclusion Criteria:

- Being a doctor working in the surgical clinics of the university hospital

Exclusion Criteria:

* INQUIRING SURVEY QUESTIONS

Primary outcomes:
measure: The attitudes of doctors working in the surgical clinic of a university hospital for patient blood management: a survey-based study
timeFrame: about 2 months
Secondary outcomes:
Other outcomes:
Locations:
city: Zonguldak
country: Turkey
facility: Gamze Küçükosman
Study officials:
References:
Clinical trial NCT04413305: WGS-guided Tracking and Infection Control Measures of CRKP
Official title: WGS-guided Tracking and Infection Control Measures of Carbapenem-resistant Klebsiella Pneumoniae
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Klebsiella Pneumoniae Infection
Lead sponsor: Huashan Hospital
Sponsor class: OTHER
Collaborators: name: Sumitomo Pharmaceuticals (Suzhou) Co. Ltd
First posted: 2020-06-02
Enrollment: 1000
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SCREENING

Brief summary: The objective of this study is to investigate the effect of the infection control measures based on the active screening of carbapenem-resistant Klebsiella pneumoniae and whole-genome based tracking and surveillance though the hospital.


Eligibility criteria: Inclusion Criteria:

1. The patient was admitted to the ICU of neurosurgery in the west hospital of huashan hospital affiliated to fudan university from September 2019 to September 2021, or transferred from the ICU of another hospital
2. The patient is more than 18 years old and less than 80 years old, regardless of gender.
3. Informed consent of the patient;

Exclusion Criteria:

1. Patients participating in other clinical trials at the same time
2. Pregnant

4. People who will affect the outcome of the study: whose specimens could not be received or not enough for testing

Primary outcomes:
measure: Evaluate the influence of WGS-based screen and control measures on the CRKP occurrence rate
timeFrame: 2 years
Secondary outcomes:
measure: Analysis of transmission pattern and route pre and post WGS-based tracking
timeFrame: 2 years
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Infectious department of Huashan Hospital, Fudan University
Study officials:
References:
Clinical trial NCT02394405: Myocardial and Renal Dysfunction by Oxidative Stress Caused by Cardiac Surgery
Official title: Myocardial and Renal Dysfunction by Oxidative Stress Caused by Cardiac Surgery
Study type: OBSERVATIONAL
Overall status: TERMINATED
Conditions: Reperfusion Injury
Lead sponsor: Moscow Regional Research and Clinical Institute (MONIKI)
Sponsor class: OTHER_GOV
First posted: 2015-03-20
Enrollment: 21
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: primary care clinic

Brief summary: Assessment of the severity of oxidative stress caused by the on-pump and off-pump cardiac surgery using mtDNA, nDNA, carbonilated proteins, nitrotyrosine, oxy-LDL, S100b-protein.


Eligibility criteria: Inclusion Criteria:

* shedduled CABG

Exclusion Criteria:

* stroke befor surgery
* miocardial infarction 6 monthes befor surgery
* dementia
* liver cirrhosis

Primary outcomes:
measure: Assay of mtDNA
timeFrame: from baseline whithin 72 hours
Secondary outcomes:
measure: Assay of nDNA
timeFrame: from baseline whithin 72 hours
measure: Assay of carbonilated proteins
timeFrame: from baseline whithin 72 hours
measure: Assay of nitrotyrosine
timeFrame: from baseline whithin 72 hours
measure: Assay of oxy-LDL
timeFrame: from baseline whithin 72 hours
measure: Assay of S100b-protein
timeFrame: from baseline whithin 72 hours
Other outcomes:
Locations:
city: Moscow
country: Russian Federation
facility: Moscow Regional Research and Clinical Institute Moniki n.a. M.F. Vladimirskiy
Study officials:
References:
Clinical trial NCT05520905: TelePrEP for At-risk Youth in Colorado
Official title: Evaluation of the Feasibility, Acceptability, and Effectiveness of TelePrEP for At-risk Youth in Colorado
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Hiv
Keywords: youth
telemedicine
telehealth
HIV
prevention
Lead sponsor: University of Colorado, Denver
Sponsor class: OTHER
Collaborators: name: Gilead Sciences
First posted: 2022-08-30
Enrollment: 100
Sex: MALE
Minimum age (years): 14
Maximum age (years): 24
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: Youth represent the largest proportion of new HIV infections in Colorado, reflective of their inadequate access and uptake of pre-exposure prophylaxis(PrEP)for HIV prevention. Colorado's 2019 HIV/AIDS Prevention Program state-wide review of PrEP barriers showed PrEP eligible individuals do not access PrEP services due to lack of interest, not wanting referral to a navigator, and low estimation of HIV risk. The overall goal is to provide youth at higher risk for HIV with an effective youth informed telemedicine delivery of PrEP (TelePrEP) that addresses PrEP barriers and contributes to ending the HIV epidemic in Colorado. The primary objective will be proportion of youth retained on PrEP 12 months after initiation. The hypotheses are that a TelePrEP model for youth will be acceptable and feasible and will result in successful initiation, persistence and retention on oral PrEP.


Eligibility criteria: Inclusion Criteria:

* HIV negative
* Eligible for PrEP using emtricitabine (F)/tenofovir alafenamide (TAF) (F/TAF) (brand name Descovy) based on current CDC guidance
* assigned male at birth
* has had male sex partners in the past 6 months (and not in a monogamous partnership with a recently tested, HIV-negative man) and
* either any sex without a condom in the past 6 months or
* a bacterial sexually transmitted infection
* Consents to TelePrEPvisits
* Willing to use current insurance coverage for clinic and laboratory services OR willing to be assisted to obtain insurance coverage OR eligible for other coverage such as Title X funds or charity care

Exclusion Criteria:

* HIV-infection or concern for acute HIV infection until ruled out
* Pregnancy
* Persons at risk through receptive vaginal sex including cisgender women and transgender men (persons assigned female sex at birth)
* Persons with only injection drug indications for PrEP without sexual risk indications outlined in inclusion criteria

Primary outcomes:
measure: Retention
timeFrame: 48 weeks
Secondary outcomes:
measure: TelePrEP Feasibility
timeFrame: 48 weeks
measure: TelePrEP Acceptability
timeFrame: 48 weeks
Other outcomes:
measure: Uptake TelePrEP
timeFrame: 48 weeks
measure: TelePrEP visit rate
timeFrame: 48 weeks
measure: TelePrEP Satisfaction
timeFrame: 48 weeks
Locations:
city: Aurora
country: United States
facility: Children's Hospital Colorado
state: Colorado
Study officials:
References:
Clinical trial NCT05329805: Effect of Job Crafting Intervention Program on Harmonious Work Passion and Career Commitment
Official title: Effect of Job Crafting Intervention Program on Harmonious Work Passion and Career Commitment Among Nurses: A Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Nurse's Role
Keywords: Job crafting
harmonious work passion
career commitment
Lead sponsor: Port Said University
Sponsor class: OTHER
First posted: 2022-04-15
Enrollment: 80
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: open-label, two-arm Randomized Control Trail (RCT)
Primary purpose: SUPPORTIVE_CARE

Brief summary: effect of job crafting intervention program on nurses' job crafting behaviors, harmonious work passion and career commitment.

Detailed description: the study aims to evulate the effectiveness ofjob crafting intervention program on nurses' job crafting behaviors, harmonious work passion and career commitment.

Hypotheses:

H1: Nurses participating in the job crafting intervention will report, post intervention, high level of job crafting behaviors compared with those nurse nurses in control group H2: Nurses participating in the job crafting intervention will report, post intervention, high level of harmonious work passion compared with those nurse nurses in control group H3: Nurses participating in the job crafting intervention will report, post intervention, high level of career commitment compared with those nurse nurses in control group this is RCT study among nurses work in EL-Nasar hospital, port said, Egypt

Eligibility criteria: Inclusion Criteria:

* licensed nurses who worked in direct contact with patients in their services
* had at least six month of experience in the nursing profession,
* agreed to participate in the study

Exclusion Criteria:

* participating in any intervention program within the last 12 months

Primary outcomes:
measure: measuring the change of the job crafting behavior of nurses
timeFrame: 3 months
Secondary outcomes:
measure: Harmonious work passion
timeFrame: 3 months
measure: career commitment
timeFrame: 3 months
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT00722605: Multiple Respiration-Correlated Cone Beam Computed Tomography (CT) Scans to Reduce Target Positioning Errors in Radiotherapy Treatment of Thoracic Cancer
Official title: The Use of Multiple Respiration-Correlated Cone Beam CT Scans to Reduce Target Positioning Errors in Radiotherapy Treatment of Thoracic Cancer.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
PHASE2
Conditions: Esophageal Cancer
Lung Cancer
Keywords: lung
esophageal
cone beam ct scan
Lead sponsor: Memorial Sloan Kettering Cancer Center
Sponsor class: OTHER
First posted: 2008-07-25
Enrollment: 16
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The purpose of this study is to use cone-beam CT scans to more accurately position the tumor during radiation and to see whether this method is more effective than the standard method of using 2D images (portal images), which is a type of X-ray. Cone-beam CT is a type of CT scanner attached to the treatment accelerator that produces 3D images of the patient.

The ability to eliminate the tumor with radiation depends in part on the accuracy of delivering the radiation to the lung. The position of the tumor changes because of normal breathing. Therefore, we want to improve the accuracy of the way the radiation is delivered to the tumor. With cone-beam CT scans taken before and during your treatment, we will be able to determine the location of the tumor with 3D images, measure how much the tumor moves as you breathe, and then position you so that the tumor will get the best delivery of radiation.


Eligibility criteria: Inclusion Criteria:

* Patients must have histologic proof of a thoracic malignancy, confirmed at MSKCC and suitable for radiation therapy, in order to be eligible for this study.
* Patients must be older than 18 years of age
* At least part of the tumor must be visible as observed in a diagnostic or planning CT. Patients must have Karnofsky Performance Status ≥ 70%

Exclusion Criteria:

* Pregnant Women

Primary outcomes:
measure: To enhance the accuracy of treatment delivery by using a cone-beam CT guided patient positioning procedure, relative to the standard portal image guided procedure.
timeFrame: conclusion of the study
Secondary outcomes:
measure: To determine the reduction in the proportion of patients with large target positioning errors using the cone-beam CT guided procedure.
timeFrame: conclusion of the study
measure: To gather data on organ motion and setup errors in the thorax and how they vary over the treatment course, in order to develop efficient clinical correction strategies.
timeFrame: conclusion of the study
Other outcomes:
Locations:
city: New York
country: United States
facility: Memorial Sloan Kettering Cancer Center
state: New York
Study officials:
affiliation: Memorial Sloan Kettering Cancer Center
name: Andreas Rimner, MD
role: PRINCIPAL_INVESTIGATOR
References: