louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02356393: Serum Magnesium Levels in Desalination Tap Water and Outcomes in Acute Myocardial Infarction Patients
Official title: The Effect of Magnesium Serum Levels on Clinical Outcomes in Patients With Acute Myocardial Infarction by Considering Desalination Drinking Water Levels Patients Fed From.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Myocardial Infarction
Death
Congestive Heart Failure
Acute-MI
Cardiovascular Disease
Keywords: Desalinated Sea Water
Magnesium
Drinking Water
Lead sponsor: Sheba Medical Center
Sponsor class: OTHER_GOV
Collaborators: name: Environment and Health Fund (EHF)
First posted: 2015-02-05
Enrollment: 150
Sex: ALL
Minimum age (years): 35
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: All Subjects 35-75 years of age with the first AMI will be prospectively recruited during 1 year from 2 regions; the Departments of Cardiology at the Sheba Medical center (300 patients, predominantly served by DSW) and the Nahariya Medical Center (150 patients, served by non-DSW).

Brief summary: Association between serum magnesium and clinical outcome in patients with acute MI (AMI) with 1 year follow-up in 300 patients in regions supplied by desalinated drinking water (DSW) (Sheba MC) and 150 patients in regions with non-desalinated drinking water (DW) (Nahariya MC).

Detailed description: Extensive seawater desalination in Israel may decrease magnesium in drinking water (DW), causing hypomagnesemia and adverse health effects. We study the association between consumption of desalinated drinking water (DSW) and serum magnesium in acute MI (AMI) patients, Subjects 35-75 years of age with the first AMI will be prospectively recruited during 1 year from 2 regions; the Departments of Cardiology at the Sheba Medical center (300 patients, predominantly served by DSW) and the Nahariya Medical Center (150 patients, served by non-DSW). Questionnaire will be developed to collect data on demographic variables (at home and work), water and beverages consumption habits (tap water, mineral water), dietary sources of Mg and Mg supplementations. Mg levels will be measured in DW from the patients' homes and in their serum on admission.

Eligibility criteria: Inclusion Criteria:

1. Patients with first AMI
2. Age 35-75

Exclusion Criteria:

1. Patients \> age 75

Primary outcomes:
measure: Number of Major Adverse Cardiovascular Events (MACE)
timeFrame: 1 year
Secondary outcomes:
measure: Age
timeFrame: 1 year
Other outcomes:
Locations:
city: Ramat Gan
country: Israel
facility: Leviev Heart Center, Chaim Sheba Medical Center
Study officials:
affiliation: Haim Sheba medical Center
name: Meital Shlezinger, PhDcandidate
role: STUDY_CHAIR
References:
Clinical trial NCT06639711: Taurine Eye Drops May Prevent the Progression of Cataract
Official title: Taurine Affects the Progression of Senile Cataract: a Single-arm Pre-post Intervention Study
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: PHASE1
PHASE2
Conditions: Cataract
Lead sponsor: University Of Anbar
Sponsor class: OTHER
First posted: 2024-10-15
Enrollment: 50
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: single-arm pre-post intervention study
Primary purpose: PREVENTION

Brief summary: The aim of the current intervention study is to determine the effectiveness of taurine containing eye drops (available under brand name VIZILOTON) to prevent the progression of grade I and II senile cataract.

This study could answer:

* Dose continuous use of taurine-containing eye drops could prevent further deterioration of vision in mild cases of cataract?
* The acceptance/ compliance of participants to taurine-containing eye drops.
* Could long-term use of taurine-containing eye drops cause adverse effect(s)?

Participants will:

* Take taurine-containing eye drops (VIZILOTON eye drops) 4 times a day for one year.
* Visit eye clinic every 3 months for assessment and visual examination.
* Keep notes for their symptoms and their adherence to treatment.


Eligibility criteria: Inclusion Criteria:

* The presence of grade I or II senile cataract on one or two eyes.

Exclusion Criteria:

* clinical signs of glaucoma
* history of amblyopia, eye surgery, argon or YAG laser eye treatment, or major eye trauma
* history of iritis, retinal crystalline deposits, or optic nerve disease
* visually significant fundus pathology

Primary outcomes:
measure: Visual Acuity
timeFrame: 1 Year
Secondary outcomes:
Other outcomes:
Locations:
city: Ramadi
country: Iraq
facility: Al-Nahrain Eye Clinics
state: Anbar
Study officials:
References:
Clinical trial NCT01970111: An Extension Study of KPS-0373 in Patients With Spinocerebellar Degeneration (SCD)
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Spinocerebellar Degeneration
Keywords: Spinocerebellar degeneration (SCD)
Thyrotropin-Releasing Hormone (TRH)
Spinocerebellar Ataxia (SCA)
Cortical Cerebellar Atrophy (CCA)
Lead sponsor: Kissei Pharmaceutical Co., Ltd.
Sponsor class: INDUSTRY
First posted: 2013-10-25
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT

Brief summary: The purpose of this study is to evaluate the long-term safety, efficacy, and pharmacokinetics of KPS-0373 in SCD patients.


Eligibility criteria: Inclusion Criteria:

* Japanese SCD patients with mild to moderate ataxia (Completion of the KPS1301 study)

Exclusion Criteria:

* Less than 75% of compliance in KPS1301 study

Primary outcomes:
measure: SARA (Scale for the Assessment and Rating of Ataxia)
timeFrame: 52 weeks
Secondary outcomes:
measure: SF-8 (QOL)
timeFrame: 52 weeks
Other outcomes:
Locations:
city: Tokyo and Other Japanese Cities
country: Japan
Study officials:
References:
Clinical trial NCT04748211: Effect of Infraclavicular and Interscalen Block on Oxygenitaon of the Forearm
Official title: Effect of Infraclavicular and Interscalen Block on Oxygenitaon of the Forearm : Randomized Controlled Study.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Upper Extremity Fracture
Lead sponsor: Bulent Ecevit University
Sponsor class: OTHER
First posted: 2021-02-10
Enrollment: 104
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: The study will be a two-arm parallel assignment. One group will receive infraclavicular block and the other will receive interscalen block
Primary purpose: TREATMENT

Brief summary: to research the oxygenitaon effects of infraclavicular and interscalene blocks on the forearm.

Detailed description: To research the oxygenation effects of infraclavicular and interscalen blocks on the forearm by comparing the blood flow (BF) values using the USG, Perfusion index (PI) and Near infrared spectroscopy (NIRS) values using the massimo device.

Eligibility criteria: Inclusion Criteria:

* aged between 18-65
* ASA Score I-III
* undergoing elective or emergency arm, elbow and forearm surgery

Exclusion Criteria:

* Patient's refusal for Brachial Plexus Blockage
* Patients who had any neurological disorders preventing the evaluation of the sensory block in the upper extremity,
* Infection in the area to be blocked with ICB or ISB,
* Non-cooperated patients
* Patients with coagulopathy,
* Morbidly obese patients
* Patients with diabetes mellitus
* Patients with hypertension
* Patients with peripheral artery disease
* Patients with allergy to the drugsto be used
* Patients who had trauma in the area scheduled for the block
* Paitens who had deterioration of anatomical integrity because of previous surgery
* Pregnant women
* Patients whose block failed

Primary outcomes:
measure: oxygenation of the forearm
timeFrame: during the procedure three times
Secondary outcomes:
Other outcomes:
Locations:
city: Zonguldak
country: Turkey
facility: Zonguldak Bulent Ecevit University
Study officials:
affiliation: Bulent Ecevit University
name: Eren Açıkgöz, M.D.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05373511: Assessing Body Posture and Postural Balance Among Young Adults With Bronchial Asthma
Official title: Evaluation of Body Posture and Postural Balance Among Young Adults With Bronchial Asthma in the United Arab Emirates - A Correlational Cross Sectional Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Bronchial Asthma
Keywords: body Posture
dynamic Balance
Biodex Balance System
DIERS FORMETRIC 4D posture analysis
Lead sponsor: Centro Universitário Augusto Motta
Sponsor class: OTHER
First posted: 2022-05-13
Enrollment: 124
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: bronchial asthma -18 years above health group ( non bronchial asthma )

Brief summary: The purpose of the study is to assess the relationship between body posture and dynamic balance in adults with childhood-onset asthma and compare them to a non-asthmatic control group matched for gender, age, weight, and height.

Detailed description: Participants will sign a consent form and provide personal information such as gender, age, weight, and height for calculating BMI, pulmonary function test, and respiratory muscle strength test, as well as their asthmatic/clinical history. After collecting demographic information and obtaining consent from participants, they will be asked to remove their T-shirts and stand in the usual relaxed standing position facing the opposite side of the machine's window. When the machine is properly positioned, it will take photographs. which will then be converted into three-dimensional images on the computer for further analysis. When the participant is fully dressed and ready, the second test will be performed using the Biodex balance machine. The parameters and testing mode to begin the dynamic balance test will be entered into the machine, and the procedure will begin. The participants will be thanked for their participation and contribution to our study

Eligibility criteria: Inclusion Criteria:

* For the healthy subjects referred by a consultant pulmonologist/physician
* age- and gender-matched volunteers were recruited from the community

Exclusion Criteria:

* Other health issues, such as cardiorespiratory issues, neurological deficits
* musculoskeletal problems and peripheral vascular diseases\& pregnancy may affect test performance

Primary outcomes:
measure: body posture assessment using DIERS FORMETRIC 4D,
timeFrame: baseline
measure: postural balance assessment by biodex balance system machine
timeFrame: baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Sharjah
country: United Arab Emirates
facility: Gopala Krishna Alaparthi
state: UAE
Study officials:
affiliation: Augusto Motta University Centre
name: Arthur De Sa Ferreira, phd
role: STUDY_CHAIR
References:
Clinical trial NCT03397511: Incorporating Financial Incentives to Increase Smoking Cessation Among Asian Americans Residing in New York City
Official title: Incorporating Financial Incentives to Increase Smoking Cessation Among Asian Americans Residing in New York City: A Feasibility Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Smoking Cessation
Smoking, Cigarette
Lead sponsor: NYU Langone Health
Sponsor class: OTHER
First posted: 2018-01-12
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Financial incentives for motivating health change have been increasingly employed in various healthcare sectors. They can be a potentially effective approach to promote smoking behavioral change and increase the use of evidence-based counseling and pharmacotherapy. Smoking cessation randomized clinical trials (RCT) incorporating financial incentives have been conducted in different populations; however, there has not been a randomized clinical trial coupled with a financial incentive with Asian American cigarette smokers. The purpose of this pilot study is to examine the feasibility of implementing an incentivized smoking cessation program among Asian American smokers in New York City.


Eligibility criteria: Inclusion Criteria:

* Asian American
* current smoker who smokes at least 10 cigarettes daily (verified by a CO level of 8 ppm or above)
* New York City resident
* able to complete three month follow-up assessments in person, can provide a telephone number
* declining the use of Chantix for smoking cessation.

Exclusion Criteria:

* \<18 years old
* pregnant
* cannot provide a telephone number, non-smokers or smokers that smoke fewer than 10 cigarettes daily, users of e-cigarettes or other tobacco products who are not interested in quitting smoking, marijuana users
* not a New York City resident
* unable to complete three month follow-up assessment in person
* unable to provide written consent
* agree to use Chantix for smoking cessation.

Primary outcomes:
measure: Number of patients recruited by implementing Financial Incentive Smoking Cessation Program among Asian American Smokers
timeFrame: One Month
Secondary outcomes:
Other outcomes:
Locations:
city: New York
country: United States
facility: New York University School of Medicine
state: New York
Study officials:
affiliation: NYU Langone Health
name: Donna Shelley, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02289911: FAST Learning Methods
Official title: Comparison of Two Learning Methods in Focused Assessment With Sonography for Trauma (FAST) Training Among Paramedics
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Trauma
Keywords: ultrasound
Lead sponsor: International Institute of Rescue Research and Education
Sponsor class: OTHER
First posted: 2014-11-13
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Training paramedics in new skills via classroom-based teaching has inherent costs and time constraints. The investigators sought to evaluate whether web-based didactics result in similar knowledge improvement and retention of FAST (Focused Assessment with Sonography for Trauma) compared with the traditional method.

Detailed description: Paramedics were randomized into a classroom group with traditional lectures and a web group that watched narrated lectures online. All participants completed a pre- and post-test, and a second post-test four weeks later. Both groups underwent hands-on training after the first post-test. A control group completed the two initial tests without didactic intervention.

Eligibility criteria: Inclusion Criteria:

* give voluntary consent to participate in the study emergency medical professionals (paramedics, nurses, physicians)

Exclusion Criteria:

* not meet the above criteria

Primary outcomes:
measure: Knowledge (Mean test scores by didactic group for three consecutive multiple choice tests)
timeFrame: 1 MONTH
Secondary outcomes:
measure: Self reported satisfaction
timeFrame: 1 MONTH
Other outcomes:
Locations:
city: Warsaw
country: Poland
facility: International Institute of Rescue Research and Education
state: Masovia
Study officials:
References:
Clinical trial NCT02517411: Physiotherapy in Patients With Stable Chronic Obstructive Pulmonary Disease
Official title: Effects of a Physiotherapy Program in Patients With Stable Chronic Obstructive Pulmonary Disease
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: COPD
Keywords: COPD
physiotherapy
Stable disease
Lead sponsor: Universidad de Granada
Sponsor class: OTHER
First posted: 2015-08-07
Enrollment: 40
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Chronic Obstructive Pulmonary Disease (COPD) is a lung disease that is characterized by incompletely reversible airflow obstruction. It is projected to be the fifth leading burden of disease worldwide by the year 2020. Pulmonary dysfunction reduces exercise capacity in COPD patients, and it has been previously shown that COPD patients suffer deterioration in their quality of life. The objective of this study is to examine the effects of a physical therapy intervention in stable patients with COPD.

Detailed description: Chronic obstructive pulmonary disease (COPD) is one of the leading diseases causing mortality and morbidity, despite advanced pharmacotherapy and therapeutic management. Although COPD primarily affects the lungs, it also implies extrapulmonary manifestations, such as nutritional depletion, skeletal muscle dysfunction, and abnormal respiratory muscles.

Pulmonary rehabilitation is widely used to treat COPD patients and it has been shown that pulmonary rehabilitation should be implemented at all COPD stages, bringing them benefits in terms of improved exercise capacity, symptoms, and quality of life.

Eligibility criteria: Inclusion Criteria:

* COPD diagnosis
* No contraindication of physiotherapy.
* Signed written consent.
* Medical approval for inclusion.

Exclusion Criteria:

* Acute exacerbation in the previous month
* Contraindications of physiotherapy.
* Neurological, orthopedic or heart disease.

Primary outcomes:
measure: Changes in Muscle strength
timeFrame: Baseline, 8 weeks
measure: Changes in Exercise capacity
timeFrame: Baseline, 8 weeks
Secondary outcomes:
measure: Changes in Respiratory function
timeFrame: Baseline, 8 weeks
measure: Changes in Dyspnea perception
timeFrame: Baseline, 8 weeks
measure: Changes in Quality of life
timeFrame: Baseline, 8 weeks
measure: Changes in Fatigue
timeFrame: Baseline, 8 weeks
measure: Impact of COPD
timeFrame: Baseline, 8 weeks
Other outcomes:
measure: Quality of life related to respiratory symptoms
timeFrame: Baseline
measure: Peripheral vascular status
timeFrame: Baseline
measure: Physical activity
timeFrame: Baseline
measure: Cognitive status
timeFrame: Baseline
Locations:
city: Granada
country: Spain
facility: Department of Physical Therapy
Study officials:
affiliation: Universidad de Granada
name: Marie Carmen Valenza, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01864811: Effect of Baby-CIMT in Infants Younger Than 12 Months
Official title: The Efficacy of Constraint Induced Movement Therapy for Babies (Baby-CIMT) in Infants Below 12 Month With Risk of Developing Unilateral Cerebral Palsy, a Study Protocol of a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cerebral Palsy
Hemiplegia
Children
Keywords: infants
unilateral cerebral pares
hand function
early intervention
constraint induced movement therapy
Lead sponsor: Karolinska Institutet
Sponsor class: OTHER
First posted: 2013-05-30
Enrollment: 35
Sex: ALL
Minimum age (years): 3
Maximum age (years): 8
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: A randomized control trial investigating if an early intervention program of modified Constraint Induced Movement Therapy for babies, Baby-CIMT, performed before 12 months of age will improve hand function in children with risk for developing cerebral palsy.

Detailed description: The investigators hypothesis is that Baby-CIMT including intensive specific task oriented training is more preferable than general stimulation which is the assumption for baby massage used in the control group. The intervention protocol is developed at Astrid Lindgren Children hospital, Stockholm Sweden.

Eligibility criteria: Inclusion Criteria:1. A neonatal history of different origin of events affecting the brain, preterm children with predominantly unilateral hemorrhage, venous infarction or with matter lesion or pre, perinatal or early postnatal stroke or Infants referred to the hospital/rehabilitation centers/specialists with signs of asymmetries before 8 month of age, likely to be diagnosed with unilateral cerebral palsy at later age.

Recruitment criteria of child characteristics

* Age can vary, earliest at 3 months of age and at the latest at 8 months
* Sign of asymmetries from mild to clear and severe asymmetries,

Exclusion Criteria:

Severe visual impairment Seizures not controlled by drugs Not unilateral CP at 12 month

Primary outcomes:
measure: Hand Assessment for Infants (HAI)
timeFrame: 12 month post term age
Secondary outcomes:
measure: Alberta Motor Infant Scale
timeFrame: Baseline and12 months post term age
Other outcomes:
measure: To Be a Parent: a questionary
timeFrame: 12 monts post preterm
Locations:
city: Stockholm
country: Sweden
facility: Astrid Lindgren Children Hospital
Study officials:
affiliation: Department of Women's and Children's Health, Karolinska Univeristy
name: Ann-Christin Eliasson, professor
role: PRINCIPAL_INVESTIGATOR
References:
citation: Greaves S, Imms C, Krumlinde-Sundholm L, Dodd K, Eliasson AC. Bimanual behaviours in children aged 8-18 months: a literature review to select toys that elicit the use of two hands. Res Dev Disabil. 2012 Jan-Feb;33(1):240-50. doi: 10.1016/j.ridd.2011.09.012. Epub 2011 Oct 11.