Clinical trial NCT02736487: Effect of Short-term Portable Air Purifier Use on Occupant Health Indicators
Official title: Effect of Short-term Portable Air Purifier Use on Occupant Health Indicators
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Non-smoking, Healthy Adults
Keywords: Air Pollution
Exposure Assessment
Filtration
Cardiovascular Outcomes
Respiratory Outcomes
Short-term Intervention
Lead sponsor: Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Sponsor class: OTHER
Collaborators: name: Duke University
name: Tsinghua University
name: Rutgers University
First posted: 2016-04-13
Enrollment: 72
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: PREVENTION

Brief summary: The purpose of this research project is to examine whether short-term use of portable air pollution filtration can result in changes in indoor airborne pollutants and impact on cardiovascular and respiratory health outcomes of the inhabitants.

Detailed description: This study will focus on evaluating the short-term benefits of a common portable air purifier technology in reducing air pollutant exposure and the anticipated concomitant health impacts. High ambient levels of various air pollutants in the Shanghai area serve as a useful model to test the portable air purifier intervention in a realistic setting. As most people using a portable air purifier would only be able to do so in their residences, the investigators have designed our study only to test residential air purifier use. Our hypothesis is that the reduction in pollutant concentrations in indoor air caused by the air purifier will result in measurable reductions in risk factors for cardiovascular and respiratory diseases.

Eligibility criteria: Inclusion Criteria:

* Healthy, non-smoking adults
* Live in the dormitory building at Shanghai First People's Hospital (South Section).

Exclusion Criteria:

* Current smokers
* Has any of the following diseases: chronic respiratory, cardiovascular, liver, renal, hematological disease; diabetes mellitus;
* Has any other diseases that may confound or complicate the effects of the intervention
* Pregnant females

Primary outcomes:
measure: Change from baseline FEV1 (forced expiratory volume in the first second of exhalation) within 2h after the filtration intervention
timeFrame: Within 2h after the filtration intervention
measure: Change from baseline R5 (airway resistance measured at 5Hz) within 2h after the filtration intervention
timeFrame: Within 2h after the filtration intervention
measure: Change in baseline exhaled nitric oxide (eNO) within 2h after the filtration intervention
timeFrame: Within 2h after the filtration intervention
measure: Change in exhaled nitric oxide (eNO) at 6h after filtration intervention compared to baseline
timeFrame: 6h after filtration intervention
measure: Change from baseline PWV (pulse wave velocity) within 2h after the filtration intervention
timeFrame: Within 2h after the filtration intervention
Secondary outcomes:
measure: Change from baseline urinary biomarkers of inflammation and oxidative stress at 0h after the filtration intervention
timeFrame: At 0h after the filtration intervention
measure: Change in baseline urinary biomarkers of inflammation and oxidative stress at 6h after filtration intervention
timeFrame: 6h after filtration intervention
measure: Change in baseline urinary biomarkers of inflammation and oxidative stress at 24h after filtration intervention
timeFrame: 24h after filtration intervention
measure: Changes in baseline blood biomarkers of inflammation, oxidative stress and coagulation within 1h after filtration intervention
timeFrame: Within 1h after filtration intervention
measure: Changes in baseline blood biomarkers of inflammation, oxidative stress and coagulation right after filtration intervention
timeFrame: 24h after filtration intervention
measure: Change in the duration of deep sleep on the first night and the second night of study participation
timeFrame: On the first night and the second night of study participation
Other outcomes:
Locations:
city: Shanghai
country: China
facility: Shanghai First People's Hospital
state: Shanghai
Study officials:
affiliation: Duke University
name: Junfeng Zhang, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Tsinghua University
name: Yinping Zhang, PhD
role: PRINCIPAL_INVESTIGATOR
References: