Clinical trial NCT06437197: Evaluation of Using Platelet-Rich Fibrin in Adult Pulpotomy
Official title: Clinical and Radiographic Evaluation of Platelets Rich Fibrin in Adult Pulpotomy: Randomized Clinical Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Irreversible Pulpitis
Keywords: Pulpotomy
Platelet Rich Fibrin
Lead sponsor: Al-Azhar University
Sponsor class: OTHER
First posted: 2024-05-31
Enrollment: 20
Sex: ALL
Minimum age (years): 25
Maximum age (years): 35
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The goal of this interventional randomized clinical trial is to evaluate the use of platelet rich fibrin in full pulpotomy in mature adult teeth.

The main questions it aims to answer are:

1. Does the use of platelet rich fibrin in complete pulpotomy in mature permanent teeth will raise the success rate of full pulpotomy of adult teeth?
2. Does the use of cone beam computed tomography scans will be more effective in early detection of apical periodontitis than periapical radiographs?

Participants will be asked to do the following:

* Receive the pulpotomy treatment of their target tooth.
* Record the pain score in the pain assessment chart.
* Attend the follow-up visits. They'll receive a full pulpotomy treatment of their target tooth. Researchers will evaluate the usage of platelet rich fibrin in performing the pulpotomy procedure of adult teeth and if cone beam computed tomography scans will be more effective in early detection of apical periodontitis than periapical radiographs.


Eligibility criteria: Inclusion Criteria:

1. Patient age: 25-35 years
2. Mature permanent premolar teeth with two separate roots.
3. Clinical diagnosis of irreversible pulpitis.
4. Patients without existing medical condition.

Exclusion criteria:

1. Immature teeth.
2. Non-restorable teeth.
3. Non-vital Teeth.
4. Uncontrolled pulpal bleeding.
5. Periodontally affected teeth.

Primary outcomes:
measure: Radiographic changes in periapical area using periapical radiographs.
timeFrame: 6 and 12 months.
Secondary outcomes:
measure: Postoperative pain
timeFrame: Immediately, 24, 48, 72 hours and 7 days.
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Faculty of Dental Medicine, Al-Azhar university
Study officials:
References:
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