Clinical trial NCT03866798: Study to Evaluate the Efficacy and Safety of PANZYGA in Pediatric Patients With Chronic Immune Thrombocytopenia (ITP)
Official title: Post-Marketing Study to Evaluate the Efficacy and Safety of PANZYGA in Pediatric Patients With Chronic Immune Thrombocytopenia (ITP)
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE4
Conditions: Chronic Immune Thrombocytopenia
Lead sponsor: Octapharma
Sponsor class: INDUSTRY
First posted: 2019-03-07
Enrollment: 6
Sex: ALL
Minimum age (years): 1
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This is a prospective, open-label, single-arm, multicenter, Phase 4 study evaluating the efficacy and safety of PANZYGA in pediatric patients with chronic ITP.


Eligibility criteria: Inclusion Criteria:

1. Females and males aged from ≥1 year to \<18 years old
2. Confirmed diagnosis of Chronic Immune Thrombocytopenia (ITP) according to American Society of Hematology (ASH) 2019 guidelines
3. Platelets count \<30x10\^9/L at the Baseline Visit
4. Voluntarily given written informed consent (provided by patient's parent or legal guardian) and assent (provided by patient \[if age-appropriate per IRB (Institutional Review Board) requirements\])
5. Sexually active females who have been using at least 1 acceptable form of birth control for a minimum of 30 days (or a minimum of 3 months for hormonal contraceptives) prior to the Screening visit and must agree to use at least 1 acceptable method of contraception throughout the study and for 30 days after the last dose of PANZYGA. Acceptable methods of birth control for this study include: intrauterine device (IUD), hormonal contraception, male or female condom, spermicide gel, diaphragm, sponge, or cervical cap. For non-sexually active females who have begun menstruating, abstinence is considered an acceptable method of birth control.
6. Parent or legal guardian must agree and be willing to assist the participant attend study visits, and to follow all protocol requirements and instructions of the study doctor

Exclusion Criteria:

1. Thrombocytopenia secondary to other diseases (such as Acquired Immunodeficiency Syndrome \[AIDS\] or systemic lupus erythematosus \[SLE\]), drug-related thrombocytopenia, or congenital thrombocytopenia
2. Administration of intravenous immunoglobulin (IGIV) or anti-D immunoglobulin within 3 weeks (+/- 3 days) before enrollment
3. Administration of thrombopoietin receptor agonists when the dose has NOT been stable within 3 weeks before enrollment and a dosage change is planned before Day 32
4. Administration of oral immunosuppressants when the dose has NOT been stable during the preceding 2 months (2 weeks for long-term corticosteroid therapy) and a dosage change is planned before Day 32 (Note: topical agents and inhaled corticosteroid therapy use is permitted)
5. Administration of long-term anti-prolific agents or attenuated androgen therapy when the dose has NOT been stable during the preceding 2 months and a dosage change is planned before Day 32
6. Nonresponsive to previous treatment with IGIV or anti-D immunoglobulin
7. Evidence of an active major bleeding episode at Screening
8. Splenectomy in the previous 3 months or planned splenectomy throughout the study period
9. Evans syndrome (experiencing active disease with 2 out of 3 of the following: autoimmune thrombocytopenia, autoimmune hemolytic anemia, and/or autoimmune neutropenia)
10. Known or suspected human immunodeficiency virus (HIV), hepatitis B virus (HBV), and/or hepatitis C virus (HCV) infections
11. Emergency surgery in the previous 4 weeks
12. Severe liver and/or kidney disease (alanine aminotransferase \[ALT\] \>3x upper limit of normal (ULN), aspartate aminotransferase \[AST\] \>3x upper limit of normal (ULN), and/or creatinine \>120 µmol/L)
13. History of severe hypersensitivity to blood or plasma derived products, or any component of the PANZYGA
14. Known immunoglobulin A (IgA) deficiency and antibodies against IgA
15. History of, or suspected alcohol or drug abuse in the previous year
16. Females who are pregnant or nursing
17. Unable or unwilling to comply with the study protocol
18. Receipt of any other investigational medicinal product within 3 months before study entry
19. Risk factors\* for thromboembolic events in whom the risks outweigh the potential benefit of PANZYGA treatment.
20. Any other condition(s), that in the Investigator's opinion, make it undesirable for the patient to participate in the study or may interfere with protocol compliance.

    * Risk factors include, but are not limited to: obesity, advanced age, hypertension, diabetes, a history of atherosclerosis/vascular disease or thrombotic events, hyperlipidemia, multiple cardiovascular risk factors, acquired or inherited thrombophilic disorders, prolonged periods of immobilization, severe hypovolemia, central venous catheterization, active malignancy and/or known or suspected hyperviscosity.

Primary outcomes:
measure: Platelet Count Increase
timeFrame: 8 Days
Secondary outcomes:
measure: Days to Reach Platelet Count of at Least 50x10^9/L
timeFrame: Through study completion, up to 37 days
measure: Duration of Platelet Response
timeFrame: Through study completion, up to 37 days
measure: Maximum Platelet Count
timeFrame: Through study completion, up to 37 days
Other outcomes:
Locations:
city: Sacramento
country: United States
facility: Octapharma Research Site
state: California
city: Minneapolis
country: United States
facility: Octapharma Research Site
state: Minnesota
city: Rochester
country: United States
facility: Octapharma Research Site
state: Minnesota
city: Columbus
country: United States
facility: Octapharma Research Site
state: Ohio
city: Toledo
country: United States
facility: Octapharma Research Site
state: Ohio
city: Philadelphia
country: United States
facility: Octapharma Research Site
state: Pennsylvania
city: Providence
country: United States
facility: Octapharma Research Site
state: Rhode Island
city: Houston
country: United States
facility: Octapharma Research Site
state: Texas
Study officials:
References: