Clinical trial NCT03352297: Nanofat in Post Burn Scars on the Face
Official title: Rejuvenation of Post Burn Scars on the Face With Unfiltered Nanofat Injection
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Burn Scar
Keywords: Post burn scar face
Unfiltered nanofat
Adipose tissue growth factors
Adipose stem cells
POSAS
Image J
Face
Lead sponsor: King Edward Medical University
Sponsor class: OTHER
First posted: 2017-11-24
Enrollment: 48
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Quasi-Experimental Study: Unfiltered Nanofat Injected into Postburn Facial Scars Number of Patients: 48 Outcome Assessed on POSAS And with Imaje J Scanning Preop And Postop Statistical Comparison of Scar Done

Detailed description: Objective: To compare the quality of post burn facial scars before and after injection of unfiltered nanofat.

Place and Duration of Study: Plastic Surgery Department, Mayo Hospital, Lahore, from January 2016 to December 2016.

Methodology: 48 patients with post burn facial scars were included, age range 4 to 32 years with Fitzpatrick skin types between 3 and 4. Patients with hypertrophic scars, contractures or keloids were excluded. Scars were assessed by a senior plastic surgeon and the patient on the POSAS. Fat was harvested from the abdomen and/or thighs with a 3 mm multi-port liposuction cannula (containing several sharp side holes of 1 mm) using Coleman's technique, emulsified, and transferred into 1 ml Leur lock syringes for injection into the subdermal or intradermal plane. Final follow up was scheduled at 6 months and scar was rated by the patient and the same surgeon on the POSAS. Pre and post op scar scores were compared and p-values calculated.

Eligibility criteria: Inclusion Criteria:

* Post burn scars on the face
* Fitzpatrick skin types between 3 and 4

Exclusion Criteria:

* Hypertrophic scars
* Contractures
* Keloids

Primary outcomes:
measure: Rejuvenation of post burn scars on the face with unfiltered nanofat injection
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: King Edward Medical University Lahore
name: Saadia Jan, FRCS ed, FCPS
role: PRINCIPAL_INVESTIGATOR
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citation: Jan SN, Bashir MM, Khan FA, Hidayat Z, Ansari HH, Sohail M, Bajwa AB, Shami HB, Hanif A, Aziz F, Choudhery MS. Unfiltered Nanofat Injections Rejuvenate Postburn Scars of Face. Ann Plast Surg. 2019 Jan;82(1):28-33. doi: 10.1097/SAP.0000000000001631.