louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT06001905: Research on the Construction of Cord Blood Storage Decision Aid Network Platform Based on "Internet +"
Official title: Research on the Construction of Cord Blood Storage Decision Aid Network Platform Based on "Internet +"
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Pregnant Women
Lead sponsor: Qianfoshan Hospital
Sponsor class: OTHER
Collaborators: name: Shandong Nursing Association
First posted: 2023-08-21
Enrollment: 400
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Only pregnant women have the right to decide whether to store umbilical cord blood. Therefore, pregnant women who have been registered in our hospital were selected in this study. The first test should be performed after 12 weeks of gestation, so pregnant women over 12 weeks of gestation should be selected.

Brief summary: Cord blood, as an important alternative source of hematopoietic stem cells, can be used to reconstruct bone marrow hematopoietic and immune function, and is an effective means to treat children with blood diseases. However, at present, the collection rate of cord blood is not high in our country, only the mother have the right to decide whether or not. At the same time, domestic studies on cord blood collection are still very limited, for the lack of effective programs and policies, which can not provide help to improve the collection level of cord blood. Therefore, in order to improve the rate of umbilical cord blood collection, it is particularly necessary to build tools to help pregnant women decide whether to retain cord blood. This topic will investigate and analyze the cognition and retention intention of pregnant women for umbilical cord blood collection. At the same time, the related process of pregnant women for umbilical cord blood retention will be deeply explored. Based on the results of quantitative and qualitative investigation, Internet technology will be used to build a network platform for pregnant women for umbilical cord blood storage decision AIDS, and the effectiveness of this tool will be evaluated. To provide theoretical basis for clinical medical workers and umbilical cord blood bank staff to establish the decision plan of cord blood storage.


Eligibility criteria: Inclusion Criteria:

* Age \> 18 years old;

  * Pregnant women whose gestational age ≥12 weeks and registered in our hospital;

    * With a certain level of education, can complete the questionnaire independently;

      * Informed consent to participate in the study

Exclusion Criteria:

* There are patients with mental illness;

  * Participated in other clinical studies in the past three months.

Primary outcomes:
measure: Construct the network platform of cord blood storage decision aid tool
timeFrame: 2024.07.10
Secondary outcomes:
Other outcomes:
Locations:
city: Jinan
country: China
facility: Zhongguo
Study officials:
References:
Clinical trial NCT05949905: A Stage-matched Intervention Based on Transtheoretical Model of Change in Changing the Videogaming Behavior
Official title: Efficacy of a Stage-matched Intervention Based on Transtheoretical Model of Change in Changing the Digital Gaming Behavior Among Male High School Students: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: ENROLLING_BY_INVITATION
Phase: NA
Conditions: Video Game Addiction
Keywords: High school students
Problematic digital gaming
Transtheoretical Model of Change
Lead sponsor: University of Baghdad
Sponsor class: OTHER
Collaborators: name: Melak Obaid Nghaimesh
First posted: 2023-07-18
Enrollment: 144
Sex: MALE
Minimum age (years): 15
Maximum age (years): 20
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: SEQUENTIAL
Primary purpose: PREVENTION

Brief summary: A Stage-matched randomized controlled trial seeks to change the problematic digital gaming behavior among high school male students.

Detailed description: The researchers will use two groups (study and control) in which participants will be randomly selected and assigned in each of the study and control groups using simple random sampling.

The study intervention will be designed based on each Stage of Change of the Transtheoretical Model of Change in that participants in each Stage of Change will receive the intervention that matches the Stage of Change they would be in.

A 12-week interval would be considered between administering the intervention and posttest 1 and the same interval would be used between posttest 1 and posttest 2.

Eligibility criteria: Inclusion Criteria:

* High school male students who do not experience any psychiatric-mental disorder.

Exclusion Criteria:

* High school male students who experience any psychiatric-mental disorder.

Primary outcomes:
measure: Stages of Change Scale for Digital Gaming Behavior
timeFrame: 6 months
Secondary outcomes:
Other outcomes:
Locations:
city: Baghdad
country: Iraq
facility: University of Baghdad
Study officials:
References:
Clinical trial NCT04833205: Clinical Efficacy and Safety of EGFR-TKI Combined With Nimotuzumab in the Treatment of Leptomeningeal Metastases From Lung Cancer
Official title: Clinical Efficacy and Safety of EGFR-TKI Combined With Nimotuzumab in the Treatment of Leptomeningeal Metastases From Lung Cancer
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE2
Conditions: Leptomeningeal Metastasis
Lung Cancer
Keywords: Leptomeningeal Metastasis
,Nimotuzumab
Lung Cancer
EGFR-TKI
Lead sponsor: Hebei Medical University
Sponsor class: OTHER
First posted: 2021-04-06
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: Clinical Efficacy and Safety of EGFR-TKI Combined With Nimotuzumab in the Treatment of Leptomeningeal Metastases From Lung Cancer.


Eligibility criteria: Inclusion Criteria:

* age 18 years or older, gender not limited;
* A definite diagnosis of Leptomeningeal metastases from lung cancer, including cerebrospinal fluid cytology and/or neuroimaging;
* Have a clear history of lung cancer, including histopathological diagnosis, or cytopathology combined with imaging diagnosis
* Patients who received any of EGFR inhibitors (gefitinib, erlotinib, afatinib, osimertinib etc.) meet the diagnostic criteria for secondary resistance and were in a slow progression stage
* Detection results of cerebrospinal fluid, blood gene or lung tissue specimens showed EGFR mutation, and immunohistochemistry results of cerebrospinal fluid, blood gene or lung tissue showed positive EGFR expression
* Bone marrow, liver, kidneys and blood clotting function are relatively stable

Exclusion Criteria:

* Eastern Cooperative Oncology Group scored \> 2 points
* Patients had poor compliance, or for other reasons the investigator considered them unsuitable to participate in the study

Primary outcomes:
measure: progression free survival
timeFrame: 2 years
Secondary outcomes:
measure: Overall Survival
timeFrame: 2 years
measure: Incidence of Treatment-Emergent Adverse Events
timeFrame: 8Weeks
Other outcomes:
Locations:
city: Hebei
country: China
facility: The Second Hospital of Hebei Medical University
state: Shijiazhuang/hebei
city: Hebei
country: China
facility: The Second Hospital of Hebei Medical University
Study officials:
affiliation: The Second Hospital of Hebei Medical University
name: jiao xue qi, master
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03677505: KoMAC Videolaryngoscope for Double-lumen Intubation
Official title: Comparison of the KoMAC Videolaryngoscope With the Macintosh Laryngoscope for Double-lumen Intubation
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Intubation
Keywords: double lumen intubation
videolaryngoscope
Lead sponsor: Ajou University School of Medicine
Sponsor class: OTHER
First posted: 2018-09-19
Enrollment: 60
Sex: ALL
Minimum age (years): 19
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: KoMAC videolaryngoscope is a portable intubating device with an angulated single-use blade of adjustable size and a liquid crystal display monitor mounted on top of the handle, which is similar in shape to the McGrath videolaryngoscope. The purpose of this study was to evaluate the efficacy of the KoMAC videolaryngoscope for double-lumen intubation regarding intubation time, laryngeal view and ease of intubation, compared to Macintosh laryngoscope.


Eligibility criteria: Inclusion Criteria:

* patients scheduled for thoracic surgery requiring one lung ventilation

Exclusion Criteria:

* predicted difficult airway
* rapid sequence intubation
* cervical injury

Primary outcomes:
measure: Intubation time
timeFrame: from 2 min after rocuronium injection to completion of intubation (time interval is about 120 seconds)
Secondary outcomes:
Other outcomes:
Locations:
city: Suwon
country: Korea, Republic of
facility: Ajou University Hospital
state: Gyeonggi-do
Study officials:
affiliation: Ajou University School of Medicine
name: Jong Yeop Kim
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06429605: Evaluating the Efficacy and Safety of Preoperative Administration of Duloxetine for Pain Management in Women Undergoing Hysterectomy Via Vaginal Route
Official title: Evaluating the Efficacy and Safety of Preoperative Administration of Duloxetine for Pain Management in Women Undergoing Hysterectomy Via Vaginal Route
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Vaginal Hysterectomy
Postoperative Pain
vNOTES
Lead sponsor: Erzincan Military Hospital
Sponsor class: OTHER
First posted: 2024-05-28
Enrollment: 80
Sex: FEMALE
Minimum age (years): 20
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Hysterectomy performed through the vaginal route (HVR) is the preferred method for women seeking hysterectomy to address uterine concerns such as premalignant conditions and fibroids. Compared to abdominal or laparoscopic approaches, HVR has shown to lead to quicker recovery times and faster resumption of daily activities. However, effectively managing postoperative pain remains a significant challenge for HVR patients.

Duloxetine, a serotonin-norepinephrine reuptake inhibitor typically prescribed for major depression and anxiety, has also been utilized in treating chronic pain conditions like osteoarthritis and musculoskeletal pain. However, research into its use for alleviating acute postoperative pain is currently limited to a single trial. Additionally, it's unclear whether perioperative duloxetine could enhance overall recovery quality after surgery. This study hypothesized that perioperative duloxetine could improve postoperative recovery for HVR patients, with evaluation using the Quality of Recovery-15 questionnaire (QoR-15).


Eligibility criteria: Inclusion Criteria:

* Patients undergoing HVR ( vaginal natural orifice transluminal endoscopic surgery) hysterectomy and salpingectomy, with the option of additional procedures such as oophorectomy, uterosacral ligament plications, trans obturator tape insertion, colporrhaphy, or sentinel lymphadenectomy
* American Society of Anesthesiologists grade 1-3

Exclusion Criteria:

* patients with chronic non-gynecologic conditions (liver-renal or pulmonary disease)
* those using psychiatric drugs (antidepressants, neuroleptics, lithium) in the last 1 year,
* those with duloxetine allergy
* those using opioids for gynecologic or non-gynecologic conditions
* additional concurrent abdominal procedures
* Total vaginal prolapsus (POPQ 4)

Primary outcomes:
measure: The primary outcome
timeFrame: 8 hours after surgery
Secondary outcomes:
measure: total QoR-15 score.
timeFrame: on postoperative day 2
Other outcomes:
Locations:
city: Muğla
country: Turkey
facility: Mugla Education and Research Hospital
Study officials:
References:
Clinical trial NCT00444405: Surgical Treatment Comparison for Recurrent Lumbar Disc Herniation
Official title: Surgical Treatment Comparison for Recurrent Lumbar Disc Herniation
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Low Back Pain
Recurrent Lumbar Disc Herniation
Keywords: lumbar
disc
herniation
discectomy
fusion
spine
Lead sponsor: Mercy Research
Sponsor class: OTHER
First posted: 2007-03-07
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Adult patients with recurrent lumbar disc herniation.

Brief summary: The purpose of this study is to compare patients who underwent decompression/discectomy with pedicle screw fusion to patients who received decompression/discectomy without fusion.

Detailed description: Lumbar disc herniations are quite common and typically improve after surgical correction. However, some patients develop recurrent herniations at the same level. Controversy exists as to why reherniated discs occur. Moreover, existing research does not settle the issue of whether a second decompression/discectomy or a repeat decompression/discectomy with pedicle screw fusion is the more successful treatment. This study is designed to compare differences in patient-reported pain, physical function, and satisfaction between the two types of surgery patients.

Eligibility criteria: Inclusion Criteria:

* Recurrent lumbar disc herniation by MRI or CT with history of decompression at the same level in the past
* Recurrent symptomatic history (with or without back pain) with radicular leg pain that improved following the first surgery
* Male or female 18-75 years old
* Flexion and extension x-rays that demonstrate an absence of sponylolisthesis or spondylolisthesis with less than 3 mm of movement

Exclusion Criteria:

* Recurrence of disc herniation within 3 months of first decompression
* Multiple level herniated discs
* No history of lumbar back surgery except as in Inclusion criteria above
* Documented severe osteoporosis or osteopenia
* Symptoms of low back pain only
* Diabetes mellitus
* Patients with suspected or diagnosed psychological/psychiatric problems that could compromise the reliability of their results
* Lumbar spondylolisthesis on flexion/extension x-rays \> 3 mm
* History of lumbar spine fractures (new or old)
* Any concurrent medical condition that may interfere with the interpretation of efficacy and safety data during the study
* Autoimmune diseases
* Age less than 18 or greater than 75 years

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: St. John's Health System, Missouri
name: Alan M. Scarrow, MD, JD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00838305: Role of Serotonin in Acute and Subacute MDMA Effects
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: MDMA Mechanism of Action
Keywords: MDMA
citalopram
serotonin
psychedelic
Lead sponsor: California Pacific Medical Center Research Institute
Sponsor class: OTHER
First posted: 2009-02-06
Enrollment: 13
Sex: ALL
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of this study is to measure the effects of MDMA (particularly its emotional effects) and to determine the role of serotonin in these effects. Serotonin is a neurotransmitter, which is a chemical that is released by some brain cells to communicate with other brain cells. Many of the effects of MDMA are thought to be the result of increased serotonin release.

In order to understand the effects of MDMA and role of serotonin in these effects, we will administer MDMA alone and in combination with the antidepressant citalopram (one trade name for this is Celexa). Citalopram decreases the ability of MDMA to release serotonin. Citalopram will therefore decrease any of MDMA's effects that are the result of serotonin release; we want to measure this.


Eligibility criteria: Inclusion Criteria:

* Healthy men or women aged 18 to 50 years
* Experienced with MDMA

Exclusion Criteria:

* Significant physical or psychiatric illness which might impair the ability to safely complete the study or that might be complicated by the study drugs, including prior seizures (after age 8), history of major depression, or other active neurological disease or clinically significant abnormalities on physical examination or screening laboratory values

Primary outcomes:
measure: To determine if administration of the selective serotonin reuptake inhibitor (SSRI) citalopram decreases the subacute (post 24hr) discontinuation effects of MDMA in experienced MDMA users given a modest dose of MDMA
timeFrame: 24 hours
Secondary outcomes:
measure: To determine if administration of the SSRI citalopram decreases the acute (post 1 to 4hr) social and emotional and cognitive effects of MDMA
timeFrame: post 1-4 hours
Other outcomes:
Locations:
city: San Francisco
country: United States
facility: CPMC Research Institute, St.Luke's Hospital
state: California
Study officials:
References:
Clinical trial NCT05314205: Ligation of Inter-sphincteric Fistula Tract for Management of Anal Fistula
Official title: Long-term Outcome of Ligation of Inter-sphincteric Fistula Tract (LIFT) for Management of Trans-sphincteric Anal Fistula
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Anal Fistula
Lead sponsor: Al-Azhar University
Sponsor class: OTHER
First posted: 2022-04-06
Enrollment: 24
Sex: ALL
Minimum age (years): 14
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients from surgery clinic at AlAzhar Hospital

Brief summary: After abscess formation, an anal fistula is a common consequence, with crypto-glandular infection being the most commonly accepted causative cause. The goal of this study was to see how well closure of the inter-sphincteric fistula tract affects the outcome of trans-sphincteric fistula surgery. Patients with perianal trans-sphincteric fistulas who underwent ligation were studied prospectively. All patients had the identical anesthetic approach, followed by the operation with two years' follow-up.


Eligibility criteria: Inclusion Criteria:

* Men and women with trans-sphincteric peri-anal fistulas (according to magnetic resonance fistulogram) of crypto-glandular source with no previous fistula surgery

Exclusion Criteria:

* Individuals with recurrent fistulae or had specific pathology, like Crohn's disease.

Primary outcomes:
measure: Post-operative complication
timeFrame: 2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Abdulkarim Hasan
Study officials:
References:
Clinical trial NCT01533805: Effects of Different Techniques of the Method Pilates in Chronic Low Back Pain
Official title: Effects of Different Techniques of the Method Pilates in Chronic Low Back Pain in Women 46 to 60 Years
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Low Back Pain
Keywords: Lumbago
Exercise therapy
Spine
Lead sponsor: Universidade Gama Filho
Sponsor class: OTHER
First posted: 2012-02-15
Enrollment: 40
Sex: FEMALE
Minimum age (years): 45
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare different methods of application of the Pilates Method with exercises in controlling in low back pain in women aged between 45 and 60 years. Two groups will be formed. One will do Pilates exercises with stabilization segmental. The other group will do classic Pilates exercises. Will be measure pre and pos intervention of the responses already shown above.

Detailed description: The purpose of this study is to identify what type of Pilates exercise is more effective in controlling low back pain is exercise that uses the method of the classical manner or trunk mobilizations with exercises that target the neutral position of the lumbar spine and deep muscles and focus on stabilizing the trunk.

Eligibility criteria: Inclusion Criteria:

* Chronic low back pain classified by visual analogue scale being 3-6 points to more than 3 weeks
* Not be performing any other type of physical therapy

Exclusion Criteria:

* Pregnant women
* Back surgeries
* Cardiovascular and rheumatic diseases

Primary outcomes:
measure: Pain
timeFrame: Up to 8 weeks
Secondary outcomes:
measure: Endurance of the back extensor muscles
timeFrame: Up to 8 weeks
measure: Activity of abdominis transversus
timeFrame: Up to 8 weeks
measure: Functional Limitation
timeFrame: Up to 8 weeks
Other outcomes:
Locations:
city: Rio de Janeiro
country: Brazil
facility: Gama Filho University
state: RJ
Study officials:
affiliation: University Gama Filho
name: Cintia P Souza, bachelor
role: PRINCIPAL_INVESTIGATOR
References: