louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05749809: The Relationship Between Lower Extremity Selective Motor Control and Gait in Children With Cerebral Palsy
Official title: The Relationship Between Lower Extremity Selective Motor Control and Gait in Children With Cerebral Palsy
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Cerebral Palsy
Lead sponsor: Tokat Gaziosmanpasa University
Sponsor class: OTHER
First posted: 2023-03-01
Enrollment: 32
Sex: ALL
Minimum age (years): 5
Maximum age (years): 20
Standard ages: CHILD
ADULT
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Cerebral palsy

Brief summary: The aim of this study is to examine the relationship between lower extremity selectivity and gait in children with cerebral palsy. 32 volunteer children with CP between the ages of 5-20 will participate in the study. The Selective Control Assessment of the Lower Extremity (SCALE) questionnaire will be used to assess lower extremity selectivity, and the Edinburgh observational gait scale will be used to assess gait. Both assessments are observational.


Eligibility criteria: Inclusion Criteria:

* Between the ages of 5-20
* Diagnosed with CP

Exclusion Criteria:

* Medical complications that limit participation in assessments (for example, severe visual impairment)
* Lower extremity surgery or botox surgery in the last 6 months
* Mental problems that cannot understand the commands given

Primary outcomes:
measure: Edinburgh Visual Gait Score
timeFrame: Baseline
measure: Selective Control Assessment of the Lower Extremity (SCALE)
timeFrame: Baseline
Secondary outcomes:
Other outcomes:
Locations:
city: Tokat
country: Turkey
facility: Faculty of Health Sciences, Tokat Gaziosmanpaşa University
Study officials:
References:
Clinical trial NCT01831609: Biomarker Analysis of Solid Cancers Such as Gastrointestinal Cancer
Official title: Biomarker Analysis of Solid Cancers Such as Gastrointestinal Cancer
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Sarcoma
Keywords: Gastrointestinal
Genitourinary
Rare Cancer
Lead sponsor: Samsung Medical Center
Sponsor class: OTHER
First posted: 2013-04-15
Enrollment: 1000
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: 1. Patients with histologically confirmed gastrointestinal, genitourinary, sarcoma, rare cancer

Brief summary: To prospectively collect ascites, pleural fluid, circulating tumor cells and derived primary cultures from metastatic cancer patients. The specimens will be analyzed using DNA/RNA/proteomic approaches.


Eligibility criteria: Inclusion Criteria:

1. Patients with histologically confirmed gastrointestinal, genitourinary, sarcoma, rare cancer
2. Written informed consent
3. body fluid derived from cancer, available for drainage and collection

Exclusion Criteria:

* patients who do not give informed consent form for research use of biomaterials/biospecimens

Primary outcomes:
measure: Biomarker analyses to predict treatment response in metastatic cancer
timeFrame: 3 year
Secondary outcomes:
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center
Study officials:
affiliation: Samsung Medical Center
name: Jeeyun Lee, professor
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02918656: Presenting Summary Information From Cochrane Systematic Reviews
Official title: Presenting Summary Information From Cochrane Systematic Reviews: Randomized Controlled Trial of Infographics Presentation vs. Standard Word Summaries
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Understanding Cochrane Systematic Reviews
Keywords: Cochrane
Abstract
Infographics
Understanding
Lead sponsor: University Hospital of Split
Sponsor class: OTHER
Collaborators: name: Croatian Science Foundation
First posted: 2016-09-29
Enrollment: 171
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: The objective of the investigators study is to evaluate the efficacy of infographics in presenting information, in terms of understanding and remembering research results, compared to standard PLS formats and scientific summary formats (SciSum).

Detailed description: The investigators will conduct a randomized control trial (RCT) with three different formats of the same systematic review summary (infographics, PLS and scientific summary). The content of these three formats is based on the same systematic review, but the ways of data presentation will differ: visual presentation, plain language, and scientific language. The trial will be performed at the beginning of the 2016/2017 academic year, with first year university students as participants. The trial will be voluntary and anonymous. The survey will consist of 4 parts: 1) demographic data, 2) one format of the summary (randomly assigned), 3) comprehension test of the information given in the summary, 4) accessibility of information and overall satisfaction with the given summary assessed by survey and 5) health numeracy test. All materials will be in Croatian. The materials used in this research will be assessed by experts in order to confirm face validity of developed questions.

Eligibility criteria: Inclusion Criteria:

* Eligible participants will be first-year university students without experience with Cochrane review summaries, because prior familiarization with Cochrane summaries could make information uptake easier by those participants.

Exclusion criteria:

* Participants who give the positive answer to the survey question about familiarity with the Cochrane will be excluded from the study analysis.

Primary outcomes:
measure: Understanding
timeFrame: One-hour after the intervention
Secondary outcomes:
measure: Reading Experience
timeFrame: One hour after the intervention
measure: Accessibility of Relevant Information
timeFrame: One hour after the intervention
measure: Health Numeracy Score
timeFrame: One hour after the intervention
Other outcomes:
Locations:
city: Split
country: Croatia
facility: School of Medicine
Study officials:
affiliation: Professor at Medical School of Split
name: Ana Marušić, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00371956: Raloxifene for Prevention of Bone Loss in Postmenopausal Patients Receiving Chronic Corticosteroid Therapy
Official title: Raloxifene for Prevention of Bone Loss in Postmenopausal Patients Receiving Chronic Corticosteroid Therapy: a Randomized Double-blind Placebo-controlled Study
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Osteoporosis
Keywords: raloxifene
estrogen
receptor
modulation
osteoporosis
steroid
Steroids
Lead sponsor: Tuen Mun Hospital
Sponsor class: OTHER_GOV
Collaborators: name: Eli Lilly and Company
First posted: 2006-09-04
Enrollment: 114
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study is a double-blind placebo-controlled trial evaluating the efficacy of raloxifene in the prevention of bone mineral density loss in patients receiving long term corticosteroids.


Eligibility criteria: Inclusion Criteria:

1. Postmenopausal patients with various chronic rheumatic diseases receiving chronic steroid therapy.
2. Stable disease for at least 6 months prior to study with a stable dose of steroid (prednisone \<= 10 mg/day or equivalent).
3. Baseline bone mineral density (BMD) of the lumbar spine T score \< -1.0.

Exclusion Criteria:

1. Patients with a history of thromboembolism.
2. Patients with positive antiphospholipid antibodies.
3. History of allergic reactions or intolerance to raloxifene or other SERMs.
4. Patients receiving bisphosphonates, parathyroid hormone, SERMs, anticonvulsants or anti-cytokine therapies within 6 months prior to study entry.
5. Patients with known bone disorders such as osteomalacia, renal osteodystrophy, and hyperparathyroidism.
6. Patients with abnormal uterine bleeding of unknown etiology.
7. Patients with serum creatinine level of \>= 200 umol/L.

Primary outcomes:
measure: Bone turnover and bone mineral density
timeFrame: 12 months
Secondary outcomes:
measure: Fracture, safety
timeFrame: 12 months
Other outcomes:
Locations:
city: Hong Kong
country: China
facility: Tuen Mun Hospital
Study officials:
affiliation: Tuen Mun Hospital Hong Kong
name: CC MOK, MD, FRCP
role: PRINCIPAL_INVESTIGATOR
References:
citation: Mok CC, Ying KY, To CH, Ho LY, Yu KL, Lee HK, Ma KM. Raloxifene for prevention of glucocorticoid-induced bone loss: a 12-month randomised double-blinded placebo-controlled trial. Ann Rheum Dis. 2011 May;70(5):778-84. doi: 10.1136/ard.2010.143453. Epub 2010 Dec 27.
Clinical trial NCT02108756: Efficacy and Safety of L-Pantoprazole Sodium Injection to Treat Upper Gastrointestinal Ulcer Bleeding
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Bleeding Gastric Ulcer
Bleeding Duodenal Ulcer
Lead sponsor: Chia Tai Tianqing Pharmaceutical Group Co., Ltd.
Sponsor class: INDUSTRY
First posted: 2014-04-09
Enrollment: 272
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the safety and Efficacy of L- Pantoprazole sodium to treat upper gastrointestinal ulcer bleeding.


Eligibility criteria: Inclusion Criteria:

1. Age: 18-65 years, gender:both.
2. Patients whose Forrest classification were in Ⅰ b-Ⅱ c were diagnosed with non-variceal duodenal and / or gastric ulcer bleeding by endoscopy within 24 hours and patients manifested vomiting and / or black stools and other symptoms of upper gastrointestinal bleeding.
3. Patients were diagnosed with upper gastrointestinal bleeding mild to moderate;
4. Informed consent granted.
5. Patients agreed to take medicine and assess.

Exclusion Criteria:

1. Patients were diagnosed with upper gastrointestinal bleeding by endoscopy caused by esophageal varices and portal hypertensive gastropathy, Mallory-Weiss syndrome, dieulafoy disease.
2. Pregnant women or breastfeeding women.
3. Patients who had undergone surgery because of ulcer complications or gastrectomy, gastrointestinal anastomosis within 30 days before the trial.
4. Patients were diagnosed with gastrinoma or gastric malignancy.
5. Patients had other associated complications, which may affect the efficacy.
6. Patients who like alcohol abuse, drug addicts or others which are not suitable for drug trials.
7. Patients who were allergic to any ingredient of any PPI and allergies.
8. Patients diagnosed with small vessel spurting who had to undergo endoscopic hemostasis or surgery or severe gastrointestinal bleeding.
9. Patients suffering from serious heart, brain, lung, liver, kidney disease or severe hypertension.
10. Patients who had coagulopathy, whose PT wasmore three seconds than normal controls, whose APTT\> 1.5 times the upper limit of normal or low-dose heparin treatment.
11. Patients whose systolic blood pressure less than 90mmHg or lower \> 30mmHg than the baseline systolic blood pressure, pulse pressure less than 20mmHg, hematocrit less than 20%.
12. Patients who participated in other clinical trials within three months before this trial.
13. Patients who need to use other drugs which may affect the trial during the trial or a week before the trial.
14. Patients who were considered unsuitable for selected candidates.

Primary outcomes:
measure: Hemostatic success rate
timeFrame: 6 days
Secondary outcomes:
Other outcomes:
Locations:
city: Xi'an
country: China
facility: The first affiliated hospital of the Fourth Military Medical University
state: Shaanxi
Study officials:
References:
Clinical trial NCT00456456: The Daily Habits Survey
Official title: The Daily Habits Survey
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Food Consumption, Sleep, and Behavior
Lead sponsor: American University
Sponsor class: OTHER
First posted: 2007-04-05
Enrollment: 300
Sex: ALL
Minimum age (years): 11
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: yes
Observational model: DEFINED_POPULATION
Time perspective: OTHER

Brief summary: Online survey for 11-17 year olds about behavior, sleep, and food consumption patterns. This survey can be completed on any computer that has internet access.

Detailed description: The following opportunity is a reserach project at the American University Behavioral Pharmacology and Health Promotions Laboratory (BPHP). The study population is 11-17 year olds. The 30 minute online survey asks questions about behavior, sleep, and typical food consumption. The purpose of this survey is to better understand these habits in young people and the effects of these habits on behavior and sleep. This information will provide us with a better understanding of the daily habits in young people and guide the direction of future research projects.

Eligibility criteria: Inclusion Criteria:

* 11-17 years old

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Washington
country: United States
facility: American University
state: District of Columbia
Study officials:
affiliation: American University
name: Britta Anderson, BA
role: PRINCIPAL_INVESTIGATOR
affiliation: American University
name: Laura Juliano, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT05734456: Comparison Between Modified Bass and Horizontal Brushing Techniques
Official title: Comparison Between Modified Bass and Horizontal Brushing Techniques for the Adequate Removal of Plaque in Dental Students; A Randomized Control Trial
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Tooth Plaque
Keywords: Toothbrushing technique
modified bass method
horizontal brushing technique
Lead sponsor: CMH Lahore Medical College and Institute of Dentistry
Sponsor class: OTHER
Collaborators: name: Bkahtawar Amin Medical and Dental College Multan
name: Sharif Medical Research Center
First posted: 2023-02-21
Enrollment: 83
Sex: ALL
Minimum age (years): 19
Maximum age (years): 24
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Undergraduate dental students in recognized dental colleges in Pakistan

Brief summary: The goal of this observational study is to determine mean plaque scores to compare the effectiveness after using modified bass and horizontal brushing technique in undergraduate dental students. The main question\[s\] it aims to answer are:

* Modified bass method is less effective than the horizontal brushing technique for plaque removal in undergraduate dental students
* Modified bass method is more effective than the horizontal brushing technique for plaque in undergraduate dental students.

Participants will check plaque scores with the help of probe and disclosing agents after applying both techniques in a separate quadrant on the same subject. Researchers will compare modified bass and a horizontal brushing technique to see which one is reliable and more effective.


Eligibility criteria: Inclusion Criteria:

* Dental students between the ages of 19-24; irrespective of gender
* Informed consent

Exclusion Criteria:

* Students undergoing orthodontic treatment
* Students having periodontal pocket
* Students who underwent scaling less or equal to 3 months ago

Primary outcomes:
measure: Plaque Index
timeFrame: 24 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Multan
country: Pakistan
facility: Bakhtawar Amin, College of Dentistry, Multan
state: Punjab
Study officials:
affiliation: Bakhtawar Amin Medical & Dental College
name: Mehvish Saleem
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04374656: Prevalence of SARS-CoV-2 in Conjunctival Swab Samples Among Patients With Conjunctivitis During the COVID-19 Pandemic
Official title: Prevalence of SARS-CoV-2 in Conjunctival Swab Samples Among Patients Presenting With Conjunctivitis to the Ophthalmology Clinics During the COVID-19 Pandemic
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Conjunctivitis
SARS-CoV-2
COVID-19
Ocular Infection, Viral
Ocular Inflammation
Keywords: conjunctivitis
SARS-CoV-2
COVID-19
Ocular Infection
viral conjunctivitis
ocular inflammation
conjunctival swab
PCR
Lead sponsor: Johns Hopkins University
Sponsor class: OTHER
First posted: 2020-05-05
Enrollment: 36
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients present or are referred to the ophthalmology clinic due to red eye complaints, suspected viral conjunctivitis, or keratoconjunctivitis will be consecutively approached and recruited if they show a willingness to participate.

Brief summary: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a newly identified, highly contagious RNA virus causing respiratory infectious disease, Coronavirus Disease 2019 (COVID-19). Conjunctivitis has been reported as a rare finding of the disease, and preliminary studies showed that the virus RNA could be detected in ocular secretions using polymerase chain reaction (PCR) assays when conjunctivitis present. This study aims to estimate the proportion of SARS-CoV-2 associated conjunctivitis among patients with suspected viral conjunctivitis presented to the ophthalmology clinics of Wilmer Eye Institute during the COVID-19 pandemic. The investigators also aim to identify whether SARS-CoV-2 associated conjunctivitis is an isolated finding or an early sign of COVID-19.


Eligibility criteria: Inclusion Criteria:

* Age 18 years old or older
* Willingness to participate
* Presents with red eye complaint

Exclusion Criteria:

* Adults lacking capacity to consent
* Adults with special needs due to physical, medical, developmental or cognitive conditions

Primary outcomes:
measure: Proportion of conjunctival samples tested positive for SARS-CoV-2
timeFrame: 1 year
Secondary outcomes:
measure: Proportion of nasal samples tested positive for SARS-CoV-2 among patients with positive conjunctival samples
timeFrame: 1 year
measure: Proportion of nasopharyngeal samples tested positive for SARS-CoV-2 among patients with positive conjunctival samples
timeFrame: 1 year
measure: Rate of development of COVID-19 in the study patient population
timeFrame: 1 year
measure: Positive conjunctival sample rate in patient developed COVID-19
timeFrame: 1 year
Other outcomes:
Locations:
city: Baltimore
country: United States
facility: Wilmer Eye Institute
state: Maryland
Study officials:
affiliation: Wilmer Eye Institute at Johns Hopkins University
name: Sezen Karakus, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05574556: Electromiographic Analysis of the Quadriceps After Trauma
Official title: Electromiographic Analysis of the Quadriceps in Individuals Undergoing Neuromuscular Electro-stimulation Intervention, Verbal Command and Neuromatrix
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Leg Injury
Bone Fracture
Lead sponsor: Faculdade de Ciências Médicas da Santa Casa de São Paulo
Sponsor class: OTHER
First posted: 2022-10-10
Enrollment: 74
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: ANALYSIS OF THE QUADRICEPS AFTER TRAUMA IN LOWER MEMBERSINTERVENTION

Brief summary: The lower limb is the region most affected by fractures in the human body. The magnitude of the trauma can cause injuries to structures adjacent to the fracture, promoting joint instability and consequently predisposition to osteoarthritis. The treatment of fractures can be performed conservatively or surgically, and one of the consequences of the surgery is arthrogenic muscle inhibition, which presents itself as a marked muscle weakness due to inhibition of the central nervous system that prevents adequate muscle activation. However, recruiting the quadriceps is the most commonly used goal to determine the patient's return to activities. Physiotherapy has several resources for the functional activation of the quadriceps muscle, such as neuromuscular electrostimulation (NMES), verbal command of muscle activation and neuromatrix techniques. Thus, the objective of this study will be to analyze, by means of electromyography, the myoelectric activity of the quadriceps muscle in individuals undergoing physical therapy intervention, affected by some fracture of the lower limb.


Eligibility criteria: Inclusion Criteria:

* trauma in lower member intervention

Exclusion Criteria:

* neuromuscular disease

Primary outcomes:
measure: electromyography
timeFrame: one time - during the procedure
Secondary outcomes:
measure: myoelectric activity of the quadriceps muscle
timeFrame: one time - during the procedure
Other outcomes:
Locations:
city: Sao Paulo
country: Brazil
facility: Claudio Cazarini Júnior
state: São Paulo
Study officials:
References:
Clinical trial NCT00449956: MK0507A Clinical Study in Patients With Glaucoma and Ocular Hypertension (0507A-149)(COMPLETED)
Official title: Multicenter, Double-Blind, Active Comparator-controlled Study to Evaluate the Safety and Efficacy of MK0507A in Patients With Glaucoma and Ocular Hypertension Who Are Inadequately Controlled on Beta-Blockers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Glaucoma
Lead sponsor: Merck Sharp & Dohme LLC
Sponsor class: INDUSTRY
First posted: 2007-03-21
Enrollment: 474
Sex: ALL
Minimum age (years): 20
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The clinical study compares safety and efficacy of MK0507A (dorzolamide 1.0% / timolol 0.5%) with 1) timolol 0.5% and with 2) concomitant therapy with dorzolamide 1.0% / timolol 0.5% in patients with glaucoma and ocular hypertension.


Eligibility criteria: Inclusion Criteria:

* Patients with glaucoma and ocular hypertension

Exclusion Criteria:

* History of ocular surgery within 3 months
* Administration contradiction to timolol and dorzolamide

Primary outcomes:
measure: Change in Intraocular Pressure (IOP) From Baseline at 8 Weeks
timeFrame: 8 weeks
Secondary outcomes:
measure: Percent Change From Baseline in Intraocular Pressure (IOP) at 8 Weeks
timeFrame: 8 Weeks
measure: Percent Change From Baseline in Outflow Pressure Reduction Rate at 8 Weeks
timeFrame: 8 weeks
Other outcomes:
Locations:
Study officials:
affiliation: Merck Sharp & Dohme LLC
name: Medical Monitor
role: STUDY_DIRECTOR
References:
citation: Kitazawa Y, Araie M; Research Group on MK-0507A. [Double-masked, phase III comparative study of the combination ophthalmic solution of the 1% dorzolamide hydrochloride/0.5% timolol maleate (MK-0507A) in patients with glaucoma and ocular hypertension]. Nippon Ganka Gakkai Zasshi. 2011 Jun;115(6):495-507. Japanese.