Clinical trial NCT01857687: Evaluation of FFR, WSS, and TPF Using CCTA
Official title: Noninvasive Evaluation of Ischemia Causing Coronary Stenosis, Wall Shear Stress, and Total Plaque Force Using Coronary CT Angiography (CCTA) and Physics-based Analytic Model Derived From Conservation of Energy
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: To Assess the Feasibility of CT-derived FFR, WSS and TPF on Coronary Atherosclerotic Plaque
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2013-05-20
Enrollment: 100
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients with coronary artery stenosis

Brief summary: To assess the feasibility of CT-derived computed fractional flow reserve (FFRCT), wall shear stress and total plaque force on coronary atherosclerotic plaque and to collect the preliminary data to apply those parameters for the prediction of clinical outcomes in patients with coronary artery stenosis.


Eligibility criteria: Inclusion Criteria:

* Consecutive patients with available CCTA within 3 months of invasive angiography and invasive imaging methods (IVUS or OCT)

Exclusion Criteria:

* Poor CT images (unable to reconstruct 3 dimensional coronary artery model)

Primary outcomes:
measure: CT-derived computed fractional flow reserve
timeFrame: at time of evaulation
Secondary outcomes:
measure: wall shear stress
timeFrame: at time of evaulation
measure: total plaque force
timeFrame: at time of evaulation
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Seoul National University hospital
city: Seoul
country: Korea, Republic of
facility: Seoul National University Hospital
Study officials:
References:
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