Clinical trial NCT05672771: The Effects of Mixed Working Memory Training on Subsequent Training Gains Among Older Adults
Official title: The Effects of Mixed Working Memory Training on Subsequent Training Gains Among Older Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Cognitive Aging
Lead sponsor: University of Illinois at Urbana-Champaign
Sponsor class: OTHER
Collaborators: name: National Institute on Aging (NIA)
First posted: 2023-01-05
Enrollment: 90
Sex: ALL
Minimum age (years): 60
Maximum age (years): 90
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: BASIC_SCIENCE

Brief summary: While an intellectually active and socially integrated lifestyle shows promise for promoting cognitive resilience, the mechanisms underlying any such effects are not well understood. The aim of the current project is test the implications of the "mutualism" hypothesis, which suggests that intellectual function emerges out of the reciprocal influence of growth in abilities as they are exercised in the ecology of everyday life. Such a view implies that improvement in one component will enhance the modifiability of a related component. An additional aim was to test the idea that mutualistic effects will be enhanced by more diverse training in related skills, such as interleaved training of multiple skills, relative to single-component training.

A "successive-enrichment" paradigm was developed to test this with working memory (WM) as the target for training given its centrality in models of attention, intellectual function, and everyday capacities such as reasoning and language comprehension. All participants receive the same target training, but the nature of the training that precedes it is manipulated. Outcome measures include pre- to posttest gains in working memory and episodic memory, as well as the rate of gain in learning the target task. The principle of enhanced mutualism would predict that more diverse experiences related to the target skill will enhance efficiency in acquiring the target skill.

Detailed description: Within conventional assessments of transfer that examine the effects of training on measures of function at a single time point, these ideas has not been tested. In this project, a "successive-enrichment" paradigm was used to examine improvement in cognitive skills as a function of different conditions for earlier training. The target for training is working memory (WM) given its centrality in models of attention, intellectual function, and everyday capacities such as reasoning and language comprehension.

In the successive-enrichment paradigm, all participants receive the same target training, but the nature of the training that precedes it is manipulated. Thus, in Phase 2, all participants are trained for 10 days on the reading span task (RdgS), in which the task is to verify sensibility in a set of sentences and retain in memory an alphabetic character presented after each sentence. The set size adapts to the participant's skill (in both accuracy of sensibility decisions and memory for the letter set). In Phase 1, participants are randomly assigned to one of four groups designed to test the assumption that related and diverse experiences with the target skill differentially enhance the rate of learning the new skill. In the Same Task (ST) control, participants train on the RdgS, and were expected to be at ceiling in Phase 2. In the Different Single condition (DS), participants trained on a WM task different from that in Phase 1 (the lexical decision span). In the Different Mixed (DM) condition, participants trained on two different interleaved WM tasks, the lexical decision span and the category span. In the non-WM Placebo Control (PC), participants train on a speeded lexical decision task (matched in materials and verbal decision component to the lexical decision span the but requiring no simultaneous memory.

Outcome measures include pre- to posttest gains in working memory and episodic memory, as well as the rate of gain in learning the RdgS in Phase 2. The PC and ST controls define the lower and upper limits of performance, respectively. The principle of enhanced mutualism would predict that the DM group will show more efficient learning of the RdgS in Phase 2 than the DS group, which will both show more efficient learning than the PC group.

Eligibility criteria: Inclusion Criteria:

* Native English speakers or acquisition of English before age 6 yrs old
* Self-report of hearing ability sufficient to engage with lab personnel
* No stroke in the last 3 years
* No current cancer treatment involving radiation or chemotherapy - No self-reported learning disability
* No self-reported psychiatric disorder
* Willingness to be randomly assigned to training conditions
* No plans that would limit participation during the activity period
* No participation in a cognitive intervention program in the last year

No additional Exclusion Criteria.

Primary outcomes:
measure: Change in Overall Working Memory
timeFrame: Change from baseline to 5-6 wks after pretest
measure: Change in Reading Span
timeFrame: Change from Baseline to 5-6 weeks after pretest
Secondary outcomes:
measure: Training Gains on the Reading Span Task in Phase 2
timeFrame: 2 weeks
Other outcomes:
Locations:
city: Urbana
country: United States
facility: Beckman Institute
state: Illinois
Study officials:
affiliation: University of Illinois at Chicago
name: Elizabeth A L Stine-Morrow, PhD
role: PRINCIPAL_INVESTIGATOR
References:
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