Clinical trial NCT04233177: The Effect of Trendelenburg Position on CCA Blood Flow
Official title: Influence of Anesthesia, Pneumoperitoneum, and Patient Position on Common Carotid Artery Blood Flow During Laparoscopic Gynecology Operation
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Perfusion
Perioperative/Postoperative Complications
Keywords: Common carotid artery
Trendelenburg
Pneumoperitoneum
Blood flow
Lead sponsor: Seoul National University Hospital
Sponsor class: OTHER
First posted: 2020-01-18
Enrollment: 20
Sex: ALL
Minimum age (years): 20
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: patients undergoing gynecology surgery under trendelenburg position

Brief summary: The investigators will evaluate the change of the common carotid artery blood flow according to patient's position and penumoperitoneum.

Detailed description: The study will include 20 patients undergoing gynecological surgery. The common carotid artery blood flow will be measured using Doppler US during the following conditions; supine position before induction of anesthesia, supine position immediately after induction of anesthesia, supine position with penumoperitoneum, head-down position with or without pneumoperitoneum.

Eligibility criteria: Inclusion Criteria:

* ASA class I,II
* patients undergoing gynecology surgery under trendelenburg position
* Age ranges from 20 to 70

Exclusion Criteria:

* BMI \> 32
* Pregnancy
* Patients who did not agree to study
* Patients with allergies to the drugs used in this study
* Patients with anatomical variations or lesions in cervical or cranial vascular portion
* Patients with arrhythmia that may alter patient's cardiac output(e.g. artrial fibrillation)

Primary outcomes:
measure: Change of the common carotid artery blood flow velocity
timeFrame: 1) baseline, 2) Immediately after induction of anesthesia, 3) immediately after pneumoperitoneum, 4) immediately after Trendelenburg position with penumoperitoneum, 5) Immediately after desufflation in Trendelenburg position
Secondary outcomes:
measure: Change of the common carotid artery beat volume
timeFrame: 1) baseline, 2) Immediately after induction of anesthesia, 3) immediately after pneumoperitoneum, 4) immediately after Trendelenburg position with penumoperitoneum, 5) Immediately after desufflation in Trendelenburg position
measure: Change of the common carotid artery diameter
timeFrame: 1) baseline, 2) Immediately after induction of anesthesia, 3) immediately after pneumoperitoneum, 4) immediately after Trendelenburg position with penumoperitoneum, 5) Immediately after desufflation in Trendelenburg position
measure: Change of mean arterial blood pressure
timeFrame: 1) baseline, 2) Immediately after induction of anesthesia, 3) immediately after pneumoperitoneum, 4) immediately after Trendelenburg position with penumoperitoneum, 5) Immediately after desufflation in Trendelenburg position
measure: Change of cardiac output
timeFrame: 1) baseline, 2) Immediately after induction of anesthesia, 3) immediately after pneumoperitoneum, 4) immediately after Trendelenburg position with penumoperitoneum, 5) Immediately after desufflation in Trendelenburg position
measure: Change of peak inspiration airway pressure
timeFrame: 1) baseline, 2) Immediately after induction of anesthesia, 3) immediately after pneumoperitoneum, 4) immediately after Trendelenburg position with penumoperitoneum, 5) Immediately after desufflation in Trendelenburg position
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Jin-Tae Kim
Study officials:
affiliation: Seoul National University Hospital
name: Jin-Tae Kim, PhD
role: PRINCIPAL_INVESTIGATOR
References: