Clinical trial NCT03203109: Determinants of Balance Recovery After Stroke - Retrospective Study
Official title: Determinants of Balance Recovery After Stroke
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Stroke
Keywords: lateropulsion
pusher syndrome
posture
balance
PASS
verticality perception
gait
Lead sponsor: University Hospital, Grenoble
Sponsor class: OTHER
First posted: 2017-06-29
Enrollment: 300
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: consecutive patients admitted in neurorehabilitation ward after first hemispheric stroke

Brief summary: Retrospective cohort study of consecutive patients investigated in a neurorehabilitation ward after a first hemispheric stroke. Postural and gait disorders in relation to referential of verticality have been analyzed in routine care.

Detailed description: 300 consecutive patients, admitted in our department for neurorehabilitation after a first hemispherical stroke, have been enrolled retrospectively. During their hospitalisation, all patients have been routinely evaluated with clinical scales, evaluating motor and cognitive deficits. Postural and visual vertical (VV) assessments have been performed 1 to 4 times during in-patient-stay.

The objective was to analyse the determinants of balance recovery after stroke, in particular the impact of wrong referential of verticality.

Data collection was performed by means of medical records. Observation period covered from january 2012 to february 2018.

Eligibility criteria: Inclusion Criteria:

first hemispheric stroke patient non-opposed to inclusion

Exclusion Criteria:

history of neurological disorders interfering with balance history of vestibularly disorders interfering with balance unstable medical conditions history of cognitive disorders

Primary outcomes:
measure: Posture
timeFrame: admission and monthly, up to 3 months
Secondary outcomes:
measure: Balance
timeFrame: admission and monthly, up to 3 months
measure: Gait
timeFrame: admission and monthly, up to 3 months
measure: Postural disorders
timeFrame: admission and monthly, up to 3 months
measure: Visual vertical perception
timeFrame: admission and monthly, up to 3 months
measure: Postural vertical perception
timeFrame: admission and monthly, up to 3 months
measure: Walking distance
timeFrame: admission and monthly, up to 3 months
measure: Gait velocity
timeFrame: admission and monthly, up to 3 months
measure: Pressure sensitivity (Hand and foot)
timeFrame: admission and monthly, up to 3 months
measure: Spasticity
timeFrame: admission and monthly, up to 3 months
measure: Laterality
timeFrame: admission and monthly, up to 3 months
measure: Disability
timeFrame: admission and monthly, up to 3 months
measure: Neuropsychological Assessment 1
timeFrame: admission and monthly, up to 3 months
measure: Neuropsychological Assessment 2
timeFrame: admission and monthly, up to 3 months
measure: Neuropsychological Assessment 3
timeFrame: admission and monthly, up to 3 months
measure: Neuropsychological Assessment 4
timeFrame: admission and monthly, up to 3 months
measure: Neuropsychological Assessment 5
timeFrame: admission and monthly, up to 3 months
measure: Neuropsychological Assessment 6
timeFrame: admission and monthly, up to 3 months
measure: Neuropsychological Assessment 7
timeFrame: admission and monthly, up to 3 months
measure: Neuropsychological Assessment 8
timeFrame: admission and monthly, up to 3 months
measure: Neuropsychological Assessment 10
timeFrame: admission and monthly, up to 3 months
measure: Falls
timeFrame: at discharge, the number of falls is totalized
measure: Visual field defect (hemianopia/quadranopia)
timeFrame: admission and monthly, up to 3 months
measure: Identification of brain structures involved in the stroke
timeFrame: once, at 2 month
Other outcomes:
Locations:
Study officials:
affiliation: University Hospital, Grenoble
name: Dominic Pérennou, MD PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Perennou D, Chauvin A, Piscicelli C; Collaborators for the posturography study in the Determinants of Balance Recovery After Stroke (DOBRAS) cohort; Hugues A, Dai S. Determining an optimal posturography dataset to identify standing behaviors in the post-stroke subacute phase. Cross-sectional study. Ann Phys Rehabil Med. 2023 May;66(4):101707. doi: 10.1016/j.rehab.2022.101707. Epub 2023 Jan 4.
citation: Dai S, Piscicelli C, Clarac E, Baciu M, Hommel M, Perennou D. Lateropulsion After Hemispheric Stroke: A Form of Spatial Neglect Involving Graviception. Neurology. 2021 Apr 27;96(17):e2160-e2171. doi: 10.1212/WNL.0000000000011826. Epub 2021 Mar 15.
citation: Dai S, Piscicelli C, Lemaire C, Christiaens A, Schotten MT, Hommel M, Krainik A, Detante O, Perennou D. Recovery of balance and gait after stroke is deteriorated by confluent white matter hyperintensities: Cohort study. Ann Phys Rehabil Med. 2022 Jan;65(1):101488. doi: 10.1016/j.rehab.2021.101488. Epub 2021 Nov 11.
citation: Dai S, Piscicelli C, Clarac E, Baciu M, Hommel M, Perennou D. Balance, Lateropulsion, and Gait Disorders in Subacute Stroke. Neurology. 2021 Apr 27;96(17):e2147-e2159. doi: 10.1212/WNL.0000000000011152. Epub 2020 Nov 11.