louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT00392483: Reuptake of an E-Learning Programme in General Practice
Official title: The Use and Diffusion of an E-learning Programme in Diagnostic Evaluation of Dementia Among General Practitioners in Denmark
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Education
Dementia
Keywords: Heading Health Plan Implementation
Computer-Assisted Instruction
General Practice
Dementia
Lead sponsor: Research Unit Of General Practice, Copenhagen
Sponsor class: OTHER
Collaborators: name: Ministry of the Interior and Health, Denmark
First posted: 2006-10-26
Enrollment: 3632
Sex: ALL
Minimum age (years): 30
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All GPs in Denmark

Brief summary: The evaluate the use and diffusion of an E-learning programme in Diagnostic Evaluation of Dementia among General Practitioners (GPs) in Denmark.

The hypothesis are:

1. The GPs do not use the guided instructions
2. The GPs using the programme are more frequently younger GPs.
3. GPs working in rural areas will use the programme more frequently

Detailed description: In a period from november 2006 to may 2007 all log files of those GPs who log on to the E-learning programme are kept by the Danish Medical Association. They are handed over to the principal investigator in an anonymous form.

Eligibility criteria: GPs stopping working as GPs in study period

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Copenhagen
country: Denmark
facility: Research Unit of General Practice
state: Capital
Study officials:
affiliation: Research Unit of General Practice
name: Frans B Waldorff, PhD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Waldorff FB, Steenstrup AP, Nielsen B, Rubak J, Bro F. Diffusion of an e-learning programme among Danish General Practitioners: a nation-wide prospective survey. BMC Fam Pract. 2008 Apr 25;9:24. doi: 10.1186/1471-2296-9-24.
Clinical trial NCT05706883: Clinical and Molecular Findings in Patients With Cervical/Supraclavicular Metastasis From Non-small-cell Lung Cancer (NSCLC)
Official title: Mutational Profile of Patients With and Without Neck and Supraclavicular Lymph Nodes Metastasis From Advanced Non-squamous Non-small-cell Lung Cancer: a Prospective Cohort Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Lung Cancer Metastatic
Lead sponsor: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Sponsor class: OTHER
First posted: 2023-01-31
Enrollment: 348
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients with clinical and radiological suspicion of advanced lung cancer

Brief summary: Despite the availability of highly effective endoscopy-based and computed tomography (CT)-based biopsy procedures, up to 50% of patients with advanced lung cancer potentially eligible for targeted therapies or immunotherapy do not have access to a diagnosis or to a thorough molecular profiling for different reasons. Enlarged and/or positron emission tomography (PET) positive cervical/supraclavicular lymph nodes (CSLs) are ideal targets for a minimally invasive diagnosis of lung cancer through a percutaneous ultrasound-guided biopsy (US-NAB). However, the prevalence of metastatic involvement of CSLs in patients with advanced lung cancer was never specifically assessed. Furthermore, the possible association of malignant CSLs involvement with molecular status was never investigated, unlike what was done for several other metastatic sites.


Eligibility criteria: Inclusion Criteria:

* Age \>18 years at the time of the procedure;
* Suspected advanced, treatment naïve non-squamous NSCLC ;
* Indication to biopsy for diagnosis and/or molecular profiling;
* Written informed consent to the study participation.

Exclusion Criteria:

* Patients with known non-squamous NSCLC sent for re-biopsy after first or second line treatment;
* Inability to stop anticoagulant or antiplatelet therapy before the procedure (except acetylsalicylic acid 100 mg/day);
* Platelet count \<50.000 per μL;
* Inability or unwillingness to provide a written informed consent.

Primary outcomes:
measure: Prevalence of KRAS mutation
timeFrame: 2 months
Secondary outcomes:
measure: Prevalence of EGFR, ALK, ROS1, BRAF, RET, MET, NTRK
timeFrame: 2 months
measure: Tumor proportion score of PD-L1
timeFrame: 2 months
measure: Prevalence of cervical/supraclavicular lymph node metastasis
timeFrame: 2 months
measure: Predictors of cervical/supraclavicular lymph node metastasis
timeFrame: 6 months
Other outcomes:
Locations:
city: Roma
country: Italy
facility: Fondazione Policlinico Universitario Agostino Gemelli IRCCS
Study officials:
affiliation: Fondazione Policlinico Universitario A. Gemelli, IRCCS
name: Rocco Trisolini, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00808483: Walking Skill Training Program Effects in Patients With Total Hip Arthroplasty
Official title: Effect of a Walking Skill Training Program in Patients Who Have Undergone Total Hip Arthroplasty: Followup One Year After Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Arthroplasty, Replacement, Hip
Exercise Therapy
Keywords: total hip arthroplasty
physical functioning
training program
self-efficacy
exercise therapy
walking
Lead sponsor: University of Oslo
Sponsor class: OTHER
First posted: 2008-12-15
Enrollment: 68
Sex: ALL
Minimum age (years): 45
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Rehabilitation plays an important part after total hip arthroplasty. In this common practice few studies have been performed on this issue.

The aims of this study were:

1. to examine the immediate effects of a walking skill training program on walking, stair climbing, balance, self-reported physical functioning physical functioning, pain and self-efficacy compared to a control group without supervised physiotherapy
2. to examine whether the effects persisted 12 months after surgery


Eligibility criteria: Inclusion Criteria:

* Primary cox arthrosis
* Good written and oral Norwegian language

Exclusion Criteria:

* Severe hip arthrosis in the other hip or severe gon arthrosis that restricted walking
* Neurological disorders
* Rheumatoid arthritis

Primary outcomes:
measure: 6 Minutes Walk Test (6MWT)
timeFrame: 5 months and 12 months
Secondary outcomes:
measure: Hip Dysfunction and Osteoarthritis Outcome Score (HOOS)
timeFrame: 5 months and 12 months
measure: Harris Hip Score (HHS)
timeFrame: 5 months and 12 months
measure: Self-efficacy
timeFrame: 5 months and 12 months
measure: Stair Climbing Test (ST)
timeFrame: 5 months and 12 months
measure: ROM Extension
timeFrame: 5 months and 12 months
measure: Index of Muscle Function (IMF)
timeFrame: 5 months and 12 months
measure: Figure-of-eight Test
timeFrame: 5 months and 12 months
Other outcomes:
Locations:
city: Oslo
country: Norway
facility: Department of health science, University of Oslo
state: Oslo 0317
Study officials:
affiliation: University of Oslo
name: Kristi E Heiberg, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Bærum Hospital Vestre Viken
name: Kristi E Heiberg, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02081183: A Study to Evaluate Efficacy of CellCept (Mycophenolate Mofetil) in Patients With Lupus Nephritis
Official title: A Study to Evaluate the Efficacy of CellCept, Administered in a Sequential Treatment Scheme, in Delaying Progressive Renal Damage in Patients With Lupus Nephritis
Study type: INTERVENTIONAL
Overall status: TERMINATED
Phase: PHASE3
Conditions: Lupus Nephritis
Lead sponsor: Hoffmann-La Roche
Sponsor class: INDUSTRY
First posted: 2014-03-07
Enrollment: 16
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study will compare the efficacy of CellCept \[0.5-2 grams per day (g/day) orally (p.o.)\] and cyclophosphamide \[0.5-1 grams per square meter (g/m2) quarterly\] as maintenance treatment for patients with lupus nephritis. All patients will receive induction treatment with cyclophosphamide (0.5-1g/m2 monthly) for 6 months, and will then be randomized to the maintenance phase of the study for a further 6 months, followed by 6 months of treatment-free follow-up. The anticipated time on study treatment is 12 months.


Eligibility criteria: Inclusion Criteria:

* adult patients \>=18 years of age;
* diagnosis of systemic lupus erythematosus and lupus nephritis (class III, IV or V).

Exclusion Criteria:

* patients who have received cytotoxic drugs in previous 8 weeks;
* systemic infections;
* hepatitis B or C, or HIV.

Primary outcomes:
measure: Creatinine Clearance
timeFrame: 18 months
measure: Urinary Protein
timeFrame: 18 months
measure: Serum Creatinine
timeFrame: 18 months
measure: Serum Albumin
timeFrame: 18 months
Secondary outcomes:
Other outcomes:
Locations:
city: Barquisimeto
country: Venezuela
city: Caracas
country: Venezuela
Study officials:
affiliation: Hoffmann-La Roche
name: Clinical Trials
role: STUDY_CHAIR
References:
Clinical trial NCT06954883: Augmented Reality Distraction for Reducing Pain in Pediatric Dental Procedures
Official title: Effectiveness of Augmented Reality as a Distraction Technique for Reducing Pain and Anxiety in Pediatric Dental Extractions: A Parallel-Group, Double-Blind Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Dental Anxiety
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2025-05-02
Enrollment: 60
Sex: ALL
Minimum age (years): 6
Maximum age (years): 10
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: This is a parallel-group, randomized controlled trial with a 1:1 allocation ratio. Participants were randomized into either the experimental group (augmented reality distraction during dental procedures) or the control group (standard tell-show-do technique). Each participant received only one of the two interventions. No crossover occurred between groups
Primary purpose: TREATMENT

Brief summary: This randomized controlled trial evaluates the effectiveness of augmented reality (AR) as a distraction technique to reduce procedural pain and anxiety in children aged 6-10 undergoing primary tooth extraction. Participants will be randomly assigned to receive either AR distraction via VR goggles or standard tell-show-do behavior management during local anesthesia administration and extraction.

Detailed description: Pain and anxiety are major challenges in pediatric dental care. AR presents an innovative, non-pharmacological technique to manage procedural distress. The study compares AR distraction versus conventional behavioral guidance in terms of self-reported pain (Wong-Baker FACES), dental anxiety (CFSS-DS), and physiological anxiety (heart rate monitoring). A double-blind design will ensure unbiased outcomes.

Eligibility criteria: Inclusion Criteria:

* Children aged 6-10 years

Indicated for anterior primary tooth extraction

No previous exposure to local anesthesia

Exclusion Criteria:

* Medically compromised children

Children with cognitive or communication impairments

Children who underwent similar treatment within the past 3 months

Primary outcomes:
measure: Pain Score using Wong-Baker FACES Scale
timeFrame: Immediately post-procedure
Secondary outcomes:
measure: 1. Children's Fear Survey Schedule-Dental Subscale
timeFrame: baseline, pre-procedure, immediately after the procedure
measure: Heart Rate as physiological indicator of anxiety
timeFrame: baseline, pre-procedure, immediately after the procedure
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT01721083: Comparison of Two Methods of Immunization for Intramuscular Injections
Official title: Comparison of Two Methods of Immunization for Intramuscular Injections
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Consequences of Immunization Method
Keywords: intramuscular injection
bunch
z-track
Lead sponsor: Christiana Care Health Services
Sponsor class: OTHER
First posted: 2012-11-04
Enrollment: 511
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This study is designed to compare two different styles of intramuscular injection (Bunch versus Z-Track)during flu vaccination with the following outcome measures as basis for comparison: perceive pain, redness, medication leakage, other complications within 72 hours in healthy adult volunteer subjects.

Detailed description: This study is designed to compare two different styles of intramuscular injection (Bunch versus Z-Track)during flu vaccination with the following outcome measures as basis for comparison: perceive pain, redness, medication leakage, other complications within 72 hours in healthy adult volunteer subjects.

Eligibility criteria: Inclusion Criteria:

* healthy adults without latex allergy over 18 years of age

Exclusion Criteria:

* latex allergy
* illness
* 18 years or less

Primary outcomes:
measure: Perceived pain
timeFrame: 72 hours
Secondary outcomes:
measure: Medication leakage
timeFrame: 72 hours
measure: Redness at injection site
timeFrame: 72 hours
Other outcomes:
Locations:
city: Newark
country: United States
facility: Christiana Care Health System
state: Delaware
Study officials:
affiliation: Christiana Care Health Services
name: Lynn E Bayne, PhD, ARNP, NNP-BC
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01743183: Influence of Respiratory Muscle Training in Elderly Hypertensive Women With Respiratory Muscle Weakness
Official title: Influence of Respiratory Muscle Training in Elderly Hypertensive Women With Respiratory Muscle Weakness
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Hypertension
Keywords: hypertension
Lead sponsor: Universidade Federal do Rio Grande do Norte
Sponsor class: OTHER
Collaborators: name: Foundation for research support from the state of Rio Grande do Norte (FAPERN)
First posted: 2012-12-06
Enrollment: 4
Sex: FEMALE
Minimum age (years): 60
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This study aims to evaluate pulmonary function and respiratory muscle strength in a group of elderly women with hypertension before and after a respiratory muscle training.

Detailed description: It is a respiratory muscle training using the Threshold for 5 weeks, with a load of 30% of maximal inspiratory pressure obtained in manometer for 30 minutes daily. Furthermore, the assessment includes: test 6-minute walk, the quality of life questionnaire, MINICHAL, the IPAQ short version, manometer and spirometry.

Eligibility criteria: Inclusion Criteria:

* diagnosis of hypertension controlled by antihypertensive;
* aged between 60 and 80 years;
* absence of dementia or cognitive impairments that limit tests;
* absence of recent myocardial infarction;
* absence of musculoskeletal limitations that limit tests;
* availability of time on training days.

Exclusion Criteria:

* clinical instability;
* inability to perform any test.

Primary outcomes:
measure: manovacuometry
timeFrame: 6 weeks
Secondary outcomes:
measure: spirometry
Other outcomes:
measure: quality of life
measure: functional capacity
measure: IPAQ
Locations:
city: Natal
country: Brazil
facility: Universidade Federal do Rio Grande do Norte
state: Rio Grande do Norte
Study officials:
affiliation: Universidade Federal do Rio Grande do Norte
name: Patrícia Nogueira
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT05914883: The NORwegian Atrial Fibrillation Self-SCREENing
Official title: The NORwegian Atrial Fibrillation Self-SCREENing
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Atrial Fibrillation
Lead sponsor: Oslo University Hospital
Sponsor class: OTHER
Collaborators: name: Sorlandet Hospital HF
name: Haukeland University Hospital
name: St. Olavs Hospital
name: University Hospital of North Norway
First posted: 2023-06-22
Enrollment: 35000
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Participants will be randomized to screening with continuous ECG screening for 3-7 days, or control/standard of care
Primary purpose: SCREENING

Brief summary: Atrial fibrillation (AF) is common, increases the risk of mortality, stroke and heart failure, and portending significant burden to patients, societal health and health economy. One of three AF cases are undiagnosed. Several methods for detection of AF exist, but most of them have major limitations and are associated with resource-demanding diagnostic workup in the speciality health care services.

Detailed description: This randomized clinical trial will evaluate whether self-screening for AF with the ECG247 patch monitor will reduce AF-related morbidity.

Eligibility criteria: Inclusion Criteria:

* Age ≥65 years and minimum one other risk factor for stroke according to the CHA2DS2-VASc risk score: Age ≥75 years, Diabetes, Heart failure, Hypertension, Previous stroke/TIA and/or Vascular disease
* Informed consent for participation

Exclusion Criteria:

* History of AF (self-reported)
* Use of anticoagulation therapy
* Pacemaker/CRT device
* No smart phone

Primary outcomes:
measure: Stroke
timeFrame: 5 years
Secondary outcomes:
Other outcomes:
Locations:
city: Oslo
country: Norway
facility: Oslo Unvirsity Hospital
Study officials:
affiliation: Oslo University Hospital
name: Sigrun Halvorsen, PhD
role: STUDY_CHAIR
References:
Clinical trial NCT04464083: IOP Measurements Using ORA After ACXL in Keratoconus
Official title: Intraocular Pressure Measurements Using Ocular Response Analyzer After Accelerated Corneal Collagen Crosslinking With Riboflavin and Ultraviolet A in Keratoconus
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: IOP Readings Before and After Accelerated Corneal Collagen Crosslinking (CXL)
Lead sponsor: Fayoum University
Sponsor class: OTHER
First posted: 2020-07-09
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: all patients with KC and indicated for CXL

Brief summary: The investigators measured IOP by Goldmann applanation tonometry(GAT) before and 6 months after accelerated 8 minutes CXL in using Avedro Kxl ,and correlated with corneal resistance factor(CRF)using ORA, AC angle and CCT using Scheimpflug imaging.


Eligibility criteria: Inclusion Criteria:

* KC patient indicated for CXL

Exclusion Criteria:

* Advanced KC Glaucoma patients

Primary outcomes:
measure: To determine IOP readings before and after accelerated corneal collagen crosslinking
timeFrame: April-October 2020
Secondary outcomes:
Other outcomes:
Locations:
city: Fayoum
country: Egypt
facility: Fayoum University
Study officials:
References:
Clinical trial NCT02937883: Empowerment Intervention for Persons With Young Onset Dementia
Official title: Effects of an Empowerment Intervention for Community-dwelling Persons With Young Onset Dementia and Their Informal Caregivers
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Dementia
Empowerment
Keywords: Daily Activities
Lead sponsor: Radboud University Medical Center
Sponsor class: OTHER
First posted: 2016-10-19
Enrollment: 60
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The purpose of this study is to evaluate the effects of an empowerment intervention for community-dwelling persons with young onset dementia and their informal caregivers.

Detailed description: This study focuses on the evaluation of an empowerment intervention developed for persons with young onset dementia and their informal caregivers. The empowerment intervention focuses on current capacities, maintenance of autonomy, and increasing the opportunities to feel useful. This pragmatic cluster randomized controlled trial aims to investigate (1) the effectiveness of the intervention concerning participants' well-being, quality of life, and behavioral issues, (2) the effect of the intervention on the informal caregivers' sense of competence and perceived distress, and (3) the impact of the intervention on healthcare costs. Furthermore, the investigators aim to study the feasibility of the intervention to frame an implementation strategy.

Participants in the intervention group will receive the intervention for 5 months. Participants of the control group receive care as usual.

Eligibility criteria: Inclusion Criteria:

* Diagnosed with dementia before the age of 65
* Living at home (community-dwelling)

Exclusion Criteria:

* Dementia is caused by Down's syndrome, Huntington's disease, HIV or alcohol-related dementia.
* Limited contact between the person with dementia and the informal caregiver (\<3 times a week)

Primary outcomes:
measure: Changes in self-management abilities
timeFrame: 5 months
Secondary outcomes:
measure: Changes in quality of life
timeFrame: 5 months
measure: Changes in neuropsychiatric symptoms Questionnaire
timeFrame: 5 months
measure: Changes in disability
timeFrame: 5 months
measure: Changes in apathy
timeFrame: 5 months
measure: Caregiver measures:Competence (
timeFrame: 5 months
measure: Caregiver measures: Emotional distress
timeFrame: 5 months
Other outcomes:
measure: Analysis of qualitative focus group interviews with participants, caregivers and health care professionals
timeFrame: 5 months
Locations:
city: Den Haag
country: Netherlands
facility: Florence
Study officials:
affiliation: Radboudumc Nijmegen
name: Raymond T CM Koopmans, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References: