louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05264428: The Effect of Honey on Lessening the Withdrawal Symptoms
Official title: The Effect of Honey on Lessening the Withdrawal Symptoms According to the Body Constitution
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Smoking Cessation
Withdrawal Symptoms
Lead sponsor: Buddhist Tzu Chi General Hospital
Sponsor class: OTHER
First posted: 2022-03-03
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This project investigates the effect of honey on lessening the withdrawal symptoms according to the body constitution.


Eligibility criteria: Inclusion Criteria:

* the cessation clinic patients aged more than 18
* only take Champix for smoking cessation

Exclusion Criteria:

* diabetes, cancer, renal disease
* with wet and hot body constitution
* allergic to honey
* accepting traditional Chinese medicine intervention

Primary outcomes:
measure: Fagerstrom Test for Nicotine Dependence
timeFrame: Before and after the 4-week trial, 3 and 6 months after the trial
measure: Minnesota Nicotine Withdrawal Scale
timeFrame: Before and after the 4-week trial
Secondary outcomes:
measure: Body Constitution Questionnaire
timeFrame: Before and after the 4-week trial
measure: Tobacco Craving Questionnaire
timeFrame: Before and after the 4-week trial
measure: Depression Anxiety Stress Scales-21
timeFrame: Before and after the 4-week trial
measure: WHOQOL-BREF
timeFrame: Before and after the 4-week trial
measure: Pittsburgh sleep quality index
timeFrame: Before and after the 4-week trial
measure: Readiness to Quit Ladder
timeFrame: Before and after the 4-week trial
Other outcomes:
Locations:
city: Hualien City
country: Taiwan
facility: Hualien Tzu Chi Hospital
Study officials:
References:
Clinical trial NCT03592628: Enhancing Postpartum Discharge Instructions
Official title: Enhancing Postpartum Discharge Instructions for Cesarean Incision Care With Assessment of Comprehension: A Pilot Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Health Literacy
Randomized Controlled Trial
Postpartum
Cesarean Delivery Affecting Newborn
Lead sponsor: Thomas Jefferson University
Sponsor class: OTHER
Collaborators: name: Rebecca Lawrence, BS
name: Sarah Cohen, MD
name: Rebecca Newbrander, MD
name: Jason K. Baxter, MD
First posted: 2018-07-19
Enrollment: 50
Sex: FEMALE
Minimum age (years): 18
Maximum age (years): 50
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: OTHER

Brief summary: Post-cesarean delivery discharge instructions are not currently at an appropriate health literacy level. Enhancing discharge instructions with a visual aid did not improve scores on comprehension quizzes, either immediately or two-weeks post-discharge. However, participants preferred to have access to visual images with discharge instructions.

Detailed description: Objective:

To evaluate the effect of a visual aid on improving comprehension of hospital discharge instructions for cesarean wound care.

Methods:

A randomized control trial with a 1:1 allocation ratio and an intention to treat analysis was performed at an urban, tertiary care center from June-November 2017. Fifty English-speaking patients ages 18-50 who had undergone a cesarean delivery were randomized to receive either standard or enhanced discharge instructions regarding post-cesarean incision care. Enhanced instructions included a visual aid not present in the standard instructions. Participants completed a comprehension quiz prior to hospital discharge and again 2 weeks after discharge as well as the REALM literacy assessment prior to discharge.

Eligibility criteria: Inclusion Criteria:

* Able to consent
* Identified as English speaking
* Had a cesarean delivery during the index hospitalization for delivery of their living newborn

Exclusion Criteria:

* Non-English speaking
* Declined to participate
* Required a translator for communication
* Intellectual disability (as self-identified or as determined by healthcare provider)
* Currently incarcerated

Primary outcomes:
measure: Comprehension Score Two Weeks Post-Discharge
timeFrame: Two weeks
Secondary outcomes:
measure: Immediate Comprehension
timeFrame: 15 minutes
Other outcomes:
Locations:
city: Philadelphia
country: United States
facility: Thomas Jefferson University Hospital
state: Pennsylvania
Study officials:
affiliation: Thomas Jefferson University
name: Rebekah McCurdy, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01402128: Efficacy and Safety of Fermented Barley on Decrement of Body Fat in Obese Subjects
Official title: The Effect of Barley Beta-glucan on Serum Lipids and Body Weight
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
PHASE3
Conditions: Overweight; Hyperlipidemia
Keywords: Soluble fiber
Polycan
Overweight
LDL-C(Low Density Lipoprotein-cholesterol)
Lead sponsor: Chonbuk National University Hospital
Sponsor class: OTHER
First posted: 2011-07-26
Enrollment: 80
Sex: ALL
Minimum age (years): 19
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: Barley, like oats, is a rich source of the soluble fibre β-glucan, which has been shown to significantly lower LDL-cholesterol (LDL-C). However, barley foods have been less widely studied.

Detailed description: This study investigated whether the supplementation of barley β-glucan is reduce the visceral fat as well as the serum low-density lipoprotein cholesterol (LDL-C) and total cholesterol (TC) in mildly hypercholesterolemic subjects. In a 12 week double-blind, controlled study, subjects were randomized to one of treatment group(3.0g/day as β-glucan) or placebo group.

Eligibility criteria: Inclusion Criteria:

* an age from 19 to 70 years,
* a BMI(Body Mass Index) \>23 kg/m\^2,
* an LDL-C(Low Density Lipoprotein-cholesterol) concentration between 110 and 250 mg/dL

Exclusion Criteria:

* they had heart disease, liver or kidney disease, food allergies, daily exercise habits, a body weight increase or decrease \>10 kg in the previous 3 months, irregular lifestyle habits
* they took medication and functional foods known to affect lipid metabolism.

Primary outcomes:
measure: Changes in Body Fat Mass(kg)
timeFrame: 12 weeks
measure: Changes in Percent Body Fat(%)
timeFrame: 12 weeks
Secondary outcomes:
measure: Changes in Visceral Adipose Tissue
timeFrame: 12 weeks
measure: Changes in LDL-C (LDL Low Density Lipoprotein-cholesterol)
timeFrame: 12 weeks
measure: Changes in HDL-C(High Density Lipoprotein-cholesterol)
timeFrame: 12 weeks
measure: Changes in Total Cholesterol
timeFrame: 12 weeks
measure: Changes in Triglyceride
timeFrame: 12 weeks
measure: Changes in FFA(Free Fatty Acid)
timeFrame: 12 weeks
measure: Changes in Apo-A1(Apolipoprotein A1)
timeFrame: 12 weeks
measure: Changes in Apo-B(Apolipoprotein B)
timeFrame: 12 weeks
measure: Changes in Subcutaneous Adipose Tissue
timeFrame: 12 weeks
Other outcomes:
Locations:
city: Jeonju
country: Korea, Republic of
facility: Clinical Trial Center for Functional Foods; Chonbuk National University Hospital
state: Jeollabuk-do
Study officials:
affiliation: Chonbuk National University Hospital
name: Soo-Wan Chae, MD., PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01634828: Method for Improved Intraoperative Blood Loss Estimates
Official title: Method for Improved Intraoperative Blood Loss Estimates
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Improved Intraoperative Blood Loss Estimates
Lead sponsor: University of Utah
Sponsor class: OTHER
First posted: 2012-07-06
Enrollment: 47
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Elective surgical patients

Brief summary: The purpose of this study is to develop a mathematical algorithm which the investigators plan to use to more accurately estimate intraoperative blood loss.


Eligibility criteria: Inclusion Criteria:

All elective surgical patients

Exclusion Criteria:

1. Age \< 18
2. Pregnant women
3. Prisoners
4. Lack of informed consent
5. Attending Physician feels enrollment could interfere with optimal patient care
6. Patients who did not have a preoperative hemoglobin measured as part of their preoperative work-up
7. Patients whose preoperative hemoglobin fraction is abnormal.
8. Patients who will likely require an intraoperative blood transfusion.
9. Patients for whom the intraoperative use of the Cell Saver is anticipated.

Primary outcomes:
measure: Estimate of intraoperative blood loss
timeFrame: duration of surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Salt lake City
country: United States
facility: University of Utah
state: Utah
Study officials:
References:
Clinical trial NCT06440928: Results of Cervical Segmental Mobilization in Patients With Chronic Lateral Epicondylitis
Official title: Investigation of the Effect of Cervical Segmental Mobilization on Pain, Functionality, Grip Strength and Quality of Life in Patients With Chronic Lateral Epicondylitis
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Epicondylitis of the Elbow
Servical Segmental Mobilization
Keywords: Lateral epicondylitis
Servical segmental mobilization
Pain
Quality of life
Grip strenght
Functionality
Lead sponsor: Halic University
Sponsor class: OTHER
First posted: 2024-06-04
Enrollment: 36
Sex: ALL
Minimum age (years): 25
Maximum age (years): 44
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: randomised controlled and experimental study
Primary purpose: SUPPORTIVE_CARE

Brief summary: The aim of our study was to investigate the effect of cervical segmental mobilization on pain, functionality, grip strength and quality of life in patients with chronic lateral epicondylitis. It was planned as a randomized controlled experimental study.


Eligibility criteria: Inclusion Criteria:

* Being between the ages of 25-44
* Being diagnosed with LE by a physician
* Not having any defined pathology in the cervical region
* No neurological problems in the upper extremities
* No history of cervical surgery

Exclusion Criteria:

* Those with a history of infection, tumor, trauma in the cervical area
* Fibromyalgia patients
* Congenital or acquired deformities of the upper extremity
* History of shoulder or elbow surgery or dislocation
* Cervical radiculopathy
* Having had Wiplash

Primary outcomes:
measure: Assessment of Pain
timeFrame: 3 weeks
measure: Quality of Life Short Form-36
timeFrame: 3 weeks
measure: Assessment of Functionality
timeFrame: 3 weeks
measure: Grip Strength
timeFrame: 3 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Yalova
country: Turkey
facility: Yalova University
Study officials:
References:
Clinical trial NCT06466928: Total Pancreatectomies in Germany - Epidemiology, Trends,
Official title: A Nationwide Analysis of Total Pancreatectomy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pancreas Disease
Keywords: Specialization
Pancreatic Surgery
Total Resection
Volume-Outcome-Relationship
Lead sponsor: Medizinische Hochschule Brandenburg Theodor Fontane
Sponsor class: OTHER
Collaborators: name: Margarete-Ammon-Stiftung
First posted: 2024-06-20
Enrollment: 12938
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The study population encompasses all patients that underwent total pancreatectomy in any German hospital (full survey of the German population).

Brief summary: The purpose of this study was to evaluate the real-world mortality rates of total pancreatectomy across Germany and to understand the impact of hospital caseload on surgical outcomes.

Detailed description: This retrospective observational study analyzed routine data from the nationwide German diagnosis-related group statistics, covering the years 2010 to 2020. The data included all inpatient episodes from acute care hospitals. The study focused on mortality rates associated with total pancreatectomy and examined how these rates varied with the complexity of the surgeries and the volume of procedures performed by different hospitals.

The mortality rates for total pancreatectomy in Germany were found to be more than three times higher than those reported by specialized pancreatic centers. Mortality rates increased significantly with the complexity of the total pancreatectomy procedures, especially those involving arterial resections. Hospitals with lower total pancreatectomy caseloads had higher mortality rates compared to high-volume centers.

Results showed that total pancreatectomies are associated with high mortality rates, particularly in hospitals with lower surgical volumes. The findings suggest that the promising outcomes from specialized centers cannot be generalized to all hospitals performing pancreatic surgeries, highlighting the need for a thorough understanding of the learning curve and specialization in pancreatic surgery to reduce mortality risks.

Eligibility criteria: Inclusion Criteria:

* total pancreatectomy between January 2010 and December 2020
* 18 years or older

Exclusion Criteria:

* postmortem pancreatectomy (OPS code 5-525.4)
* removal of a pancreas transplant (OPS code 5-525.3)

Primary outcomes:
measure: In-hospital mortality
timeFrame: 30 days
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Head of Surgery at University Hospital Brandenburg an der Havel
name: Rene Mantke, MD, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT00636428: Clinical Trial of Oral Midazolam in Pediatric Endoscopy
Official title: Clinical Trial of Oral Midazolam in Pediatric Endoscopy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Endoscopy
Keywords: endoscopy
Midazolam
pediatric
sedation
comfort
Lead sponsor: Tabriz University
Sponsor class: OTHER
First posted: 2008-03-14
Enrollment: 50
Sex: ALL
Minimum age (years): 3
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: SUPPORTIVE_CARE

Brief summary: The objective of our study was to compare the safety and efficacy of oral midazolam during pediatric endoscopy.

Detailed description: Although gastrointestinal endoscopy is widely accepted as fundamental to the diagnosis and treatment of digestive disorders in children, considerable controversy and practice differences persist with respect to the methods and agents used to achieve optimal endoscopic sedation.

Comparison:oral midazolam vs midazolam IV in sedation and comfort scale of pediatric endoscopy.

Eligibility criteria: Inclusion Criteria:

* All of patients scheduled for endoscopy participated in the study.

Exclusion Criteria:

Exclusion criteria were as follows:

* Children younger than 3 years;
* Children with significant neurological disability;
* Children with a history of allergies to benzodiazepines, or to their components;
* Children with metabolic, cardiac or renal disease; children with previous - Complications to IV sedation;
* Children with respiratory distress
* Age under 1 mo and bigger than 17y
* History of erythromycin used in 4 week ago

Primary outcomes:
measure: efficacy and safety of endoscopy in children with used midazolam
Secondary outcomes:
measure: The level of sedation
measure: patient complications, ease of performing the procedure, time of preparation, time for recovery
Other outcomes:
Locations:
city: Tabriz
country: Iran, Islamic Republic of
facility: Liver &Gastrointestinal Research center of tabriz medical university
state: East Azarbijan
Study officials:
affiliation: liver &Gastrointestinal Research center of tabriz medical university
name: mandana Rafeey, Dr
role: STUDY_CHAIR
affiliation: tabriz medical university
name: Mandana Rafeey, Dr
role: STUDY_CHAIR
References:
Clinical trial NCT00863928: Effects of Perioperative B&O Suppositories on Post-op Pain and Morphine Use After Laparoscopic Prostatectomy
Official title: Effects of Perioperative Belladonna and Opium Suppositories on Postoperative Pain and Morphine Consumption on Patients After Robotic Assisted Laparoscopic Radical Prostatectomy
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Pain
Lead sponsor: Benaroya Research Institute
Sponsor class: OTHER
Collaborators: name: Virginia Mason Hospital/Medical Center
First posted: 2009-03-18
Enrollment: 135
Sex: MALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This study is evaluating the effect of a Belladonna and Opium suppository administered intraoperatively on post operative pain after laparoscopic radical prostatectomy for prostate cancer. This is a blinded randomized study. 50% of patients will receive the suppository, 50% of patients will not. Neither you or your surgeon will know which group you are in.

Detailed description: All patients undergoing LRP at Virginia Mason Medical Center between November 1, 2008 and July 30, 2009 were offered the opportunity to participate in a randomized double blind clinical trial. Operating surgeons were blinded to suppository placement which was administered after induction of anesthesia. All patients underwent a standardized anesthesia regimen. Post-operative pain was assessed by a visual analog scale (VAS) and post-operative narcotic use was calculated in intravenous morphine equivalents.

Eligibility criteria: Inclusion Criteria:

* Patients scheduled for laparoscopic radical prostatectomy at Virginia Mason, who do not have chronic pain or allergies to opioid analgesics are eligible for this study.

Exclusion Criteria:

* Women are excluded due to the absence of a prostate.
* Children are excluded due to the absence of prostate cancer in this group.
* Patients meeting any of the following will not be eligible for the study:

  * Patients at risk for complications from anticholinergic agents including those with a history of glaucoma, bronchial asthma, convulsive disorder, or high risk for delirium
  * History of previous allergies or adverse reactions to belladonna and opium and/or opioid analgesics
  * History of chronic pain or chronic use of opioid and nonopioid analgesics
  * History of alcohol or opioid dependency/abuse within last three months

Primary outcomes:
measure: Pain Assessment by Visual Analog Scale at Rest
timeFrame: 24 hours
Secondary outcomes:
Other outcomes:
Locations:
city: Seattle
country: United States
facility: Virginia Mason Medical Center
state: Washington
Study officials:
affiliation: Benaroya Research Institute
name: John M Corman, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06808828: Occupational Therapy for Adults Who Have Experienced Intimate Partner Violence (IPV)
Official title: Occupational Therapy for Adults Who Have Experienced Intimate Partner Violence
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Domestic Violence
Keywords: domestic violence
intimate partner violence
occupational therapy
Lead sponsor: Loma Linda University
Sponsor class: OTHER
First posted: 2025-02-05
Enrollment: 25
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Participants will attend a 90-minute session twice a week sessions per week for four weeks. During the session, participants will receive education on resilience and developing healthy lifestyles. Participants will be assessed at baseline with a pre-test and post-intervention with a post-test. In addition, participants will complete the occupational therapy lifestyle medicine check-in at each session.
Primary purpose: TREATMENT

Brief summary: The purpose of this graduate student research study is to understand the effectiveness of an occupational therapy program in a domestic violence shelter. It is expected that participation will last about 6 weeks. Subjects will complete pretests involving lifestyle assessments and a coping scale and then participate in 8 occupational therapy sessions during the 4 weeks of program implementation. The occupational therapy sessions will last approximately 90 minutes. After the program is completed, subjects will complete the posttests.

Procedures and Activities. You will be asked to:

Complete a series of questionnaires about your health, well-being, and daily activities.

Participate in 8 OT sessions that may include activities such as journaling, positive self-talk, coping skills methods, and grounding exercises.

Complete the posttests.


Eligibility criteria: Inclusion Criteria:

* Male or Female 18 years of age or older receiving services from a domestic violence organization

Exclusion Criteria:

* None

Primary outcomes:
measure: Improvement in Healthy Lifestyle
timeFrame: Change between baseline assessment at initial enrollment and completion of Session 8 at 8 weeks post-enrollment.
measure: Improvement in Quality of Life
timeFrame: Change between the baseline assessment and post-test at study completion, up to 9 weeks post-enrollment
measure: Improvement in Coping Skills
timeFrame: Change between the baseline assessment and post-test at study completion, up to 9 weeks post-enrollment.
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Loma Linda University
name: Heather Javaherian, OTD
role: PRINCIPAL_INVESTIGATOR
References: