Clinical trial NCT06548542: Study of Targeted Therapies for the Treatment of Adult Participants With Moderate to Severe Crohn's Disease
Official title: A Phase 2a Multicenter, Randomized, Platform Study of Targeted Therapies for the Treatment of Adult Subjects With Moderate to Severe Crohn's Disease
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE2
Conditions: Crohn's Disease
Keywords: Crohn's Disease
Risankizumab
ABBV-382
Lutikizumab
Lead sponsor: AbbVie
Sponsor class: INDUSTRY
First posted: 2024-08-12
Enrollment: 500
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: SEQUENTIAL
Primary purpose: TREATMENT

Brief summary: Crohn's disease (CD) is a long-lasting disease that causes severe inflammation (redness, swelling), in the digestive tract, most frequently affecting the bowels. It can cause many different symptoms including belly pain, diarrhea, tiredness, and weight loss. Treatments are available but do not work the same for all patients or may stop working over time. This study will evaluate the effectiveness and adverse events of targeted therapies (TaTs) for adult participants with moderate to severe CD.

The medicines assessed in this study are risankizumab, ABBV-382 and lutikizumab. When participants join the study, they will be randomized into available study treatment groups. Adult participants with CD will be enrolled. Around 500 participants will be enrolled in the study at approximately 300 sites worldwide.

Risankizumab and ABBV-382 are given as an injection under the skin or as an infusion into the vein. Lutikizumab is given as an injection under the skin. Each group includes a 12-week induction period, a 12-week maintenance period, and an optional long-term extension period where medication will be given after the maintenance period.

There may be higher treatment burden for participants in this trial compared to their standard of care treatment without participating in this study. Participants will attend regular visits during the study at a hospital or clinic. The effect of the treatment will be checked by medical assessments, blood tests, endoscopies, checking for side effects and completing questionnaires and a daily diary.


Eligibility criteria: Inclusion Criteria:

* Participants' body weight must be ≥ 40 kg at Baseline.
* Confirmed diagnosis of CD for at least 3 months prior to Baseline. Documentation of biopsy results consistent with the diagnosis of CD as assessed by the Investigator must be available.
* CDAI ≥ 220 at Baseline.
* Endoscopic evidence of mucosal inflammation as documented by an SES-CD of ≥ 6 for ileocolonic or colonic disease or SES-CD of ≥ 4 for isolated ileal disease. All eligible scores exclude the presence of narrowing component and are determined by a reader.
* Participants must demonstrate intolerance or inadequate response to TaTs including biologics

Exclusion Criteria:

* Participant who demonstrated intolerance to p19 inhibitors, including risankizumab.
* Participant who received any investigational TaT (or TaT that becomes approved during the conduct of the study) within 30 days or 5 half-lives prior to Baseline, whichever is longer. Note: If there is documentation of an undetectable (or below the lower limit of quantification/quantitation) drug level measured by a commercially available assay for any of the approved biologics above, there is no minimum washout prior to Baseline.
* Participant who have any of the following: Current diagnosis of UC or indeterminate colitis. Currently known complications of CD such as: Current ostomy or ileoanal pouch; Current short gut or short bowel syndrome; Surgical bowel resection within the past 3 months prior to Baseline.

Primary outcomes:
measure: Percentage of Participants who Achieve Endoscopic Remission
timeFrame: Week 12
Secondary outcomes:
measure: Percentage of Participants With Clinical Remission Per Crohn's Disease Activity Index (CDAI)
timeFrame: Week 12
measure: Percentage of Participants With Clinical Remission Per Stool Frequency/Abdominal Pain Score (SF/APS)
timeFrame: Week 12
measure: Percentage of Participants who Achieve Endoscopic Response
timeFrame: Week 12
Other outcomes:
Locations:
city: Dothan
country: United States
facility: Digestive Health Specialists /ID# 266216
state: Alabama
city: Mobile
country: United States
facility: East View Medical Research /ID# 270377
state: Alabama
city: Coronado
country: United States
facility: Southern California Res. Ctr /ID# 265549
state: California
city: La Jolla
country: United States
facility: UC San Diego Health System /ID# 265565
state: California
city: Sacramento
country: United States
facility: uc davis medical center - patient support services building /ID# 265554
state: California
city: San Diego
country: United States
facility: Clinical Applications Laboratories - San Diego - 3rd Avenue /ID# 267391
state: California
city: Colorado Springs
country: United States
facility: Peak Gastroenterology Associates - Colorado Springs - North Cascade Avenue /ID# 265557
state: Colorado
city: Danbury
country: United States
facility: Danbury Hospital, Western Connecticut Health Network /ID# 265556
state: Connecticut
city: New Haven
country: United States
facility: Yale University School of Medicine /ID# 266786
state: Connecticut
city: Inverness
country: United States
facility: Nature Coast Clinical Research - Inverness /ID# 265874
state: Florida
city: Margate
country: United States
facility: Atlantic Medical Research /ID# 266207
state: Florida
city: Miami
country: United States
facility: A Plus Research /ID# 265878
state: Florida
city: Miami
country: United States
facility: Sanchez Clinical Research /ID# 265887
state: Florida
city: New Port Richey
country: United States
facility: Advanced Research Institute, Inc /ID# 265548
state: Florida
city: Orange City
country: United States
facility: Hillcrest Medical Research, LLC /ID# 267237
state: Florida
city: Orlando
country: United States
facility: Endoscopic Research, Inc. /ID# 267211
state: Florida
city: Tampa
country: United States
facility: AdventHealth Medical Group - Tampa - Bruce B Downs Boulevard /ID# 265538
state: Florida
city: Zephyrhills
country: United States
facility: Florida Medical Clinic - Zephyrhills /ID# 267392
state: Florida
city: Macon
country: United States
facility: Gastroenterology Associates of Central Georgia /ID# 265547
state: Georgia
city: Boise
country: United States
facility: Treasure Valley Medical Research /ID# 267114
state: Idaho
city: Chicago
country: United States
facility: University of Chicago Medical Center /ID# 267400
state: Illinois
city: Peoria
country: United States
facility: OSF St. Francis Medical Center /ID# 266973
state: Illinois
city: Springfield
country: United States
facility: Springfield Clinic Main Campus /ID# 267434
state: Illinois
city: Lexington
country: United States
facility: University of Kentucky Chandler Medical Center /ID# 265564
state: Kentucky
city: Chevy Chase
country: United States
facility: Metropolitan Gastroenterology Group - Chevy Chase /ID# 265877
state: Maryland
city: New Bedford
country: United States
facility: Lucida Clinical Trials /ID# 266548
state: Massachusetts
city: Columbia
country: United States
facility: GI Associates Research, LLC /ID# 267433
state: Missouri
city: Liberty
country: United States
facility: BVL Clinical Research /ID# 265870
state: Missouri
city: Saint Louis
country: United States
facility: Washington University School of Medicine - St. Louis /ID# 266938
state: Missouri
city: Las Vegas
country: United States
facility: Vector Clinical Trials /ID# 265561
state: Nevada
city: Great Neck
country: United States
facility: NYU Langone Long Island Clinical Research Association /ID# 265566
state: New York
city: New York
country: United States
facility: Icahn School of Medicine at Mount Sinai /ID# 266857
state: New York
city: New York
country: United States
facility: Lenox Hill Hospital /ID# 265527
state: New York
city: Yonkers
country: United States
facility: Care Access - Yonkers /ID# 266781
state: New York
city: Asheville
country: United States
facility: Digestive Health Partners - Biltmore Office /ID# 265539
state: North Carolina
city: Durham
country: United States
facility: Velocity Clinical Research - Durham /ID# 267712
state: North Carolina
city: Cincinnati
country: United States
facility: University of Cincinnati /ID# 265589
state: Ohio
city: Columbus
country: United States
facility: The Ohio State University /ID# 265577
state: Ohio
city: Oklahoma City
country: United States
facility: Digestive Disease Specialists - Oklahoma /ID# 265901
state: Oklahoma
city: Hershey
country: United States
facility: Penn State Health Milton South Hershey Medical Center /ID# 267126
state: Pennsylvania
city: Philadelphia
country: United States
facility: University of Pennsylvania /ID# 265904
state: Pennsylvania
city: Orangeburg
country: United States
facility: Gastroenterology Associates of Orangeburg /ID# 267548
state: South Carolina
city: Johnson City
country: United States
facility: GI associates of Northeast Tennessee /ID# 265567
state: Tennessee
city: Cedar Park
country: United States
facility: Gi Alliance - Cedar Park /ID# 268153
state: Texas
city: El Paso
country: United States
facility: Proactive Clinical Research /ID# 267305
state: Texas
city: Garland
country: United States
facility: Digestive Health Associates of Texas (DHAT) Research Institute - Garland /ID# 266935
state: Texas
city: Houston
country: United States
facility: Houston Methodist Hospital /ID# 265533
state: Texas
city: Lubbock
country: United States
facility: Caprock Gastro Research - Lubbock - 80th Street /ID# 265541
state: Texas
city: Mansfield
country: United States
facility: GI Alliance: Mansfield /ID# 266947
state: Texas
city: San Antonio
country: United States
facility: Clinical Associates in Research Therapeutics of America, LLC /ID# 265899
state: Texas
city: San Antonio
country: United States
facility: Sun Research Institute /ID# 266723
state: Texas
city: Southlake
country: United States
facility: Texas Digestive Disease Consultants - Southlake /ID# 265576
state: Texas
city: Tyler
country: United States
facility: Tyler Research Institute, LLC /ID# 265545
state: Texas
city: Ogden
country: United States
facility: Care Access - Ogden /ID# 266428
state: Utah
city: Salt Lake City
country: United States
facility: Care Access - Salt Lake City /ID# 266785
state: Utah
city: Tacoma
country: United States
facility: Washington Gastroenterology - Tacoma /ID# 267302
state: Washington
city: Linz
country: Austria
facility: Ordensklinikum Linz - Barmherzige Schwestern /ID# 265929
state: Oberoesterreich
city: Wels
country: Austria
facility: Klinikum Wels-Grieskirchen GmbH /ID# 266035
state: Oberoesterreich
city: Innsbruck
country: Austria
facility: Medizinische Universitaet Innsbruck /ID# 265930
state: Tirol
city: Salzburg
country: Austria
facility: Landeskrankenhaus Salzburg-Universitaetsklinikum der PMU (LKH) /ID# 265928
city: Wien
country: Austria
facility: Medizinische Universitaet Wien /ID# 265926
city: Bonheiden
country: Belgium
facility: Imelda Ziekenhuis /ID# 265995
state: Antwerpen
city: Anderlecht
country: Belgium
facility: Universite Libre de Bruxelles - Hopital Erasme /ID# 265993
state: Bruxelles-Capitale
city: Brussels
country: Belgium
facility: CHU Saint-Pierre /ID# 266431
state: Bruxelles-Capitale
city: Bruxelles
country: Belgium
facility: Cliniques Universitaires UCL Saint-Luc /ID# 265521
state: Bruxelles-Capitale
city: Liège
country: Belgium
facility: CHU de Liège /ID# 265542
state: Liege
city: Yvoir
country: Belgium
facility: Université Catholique de Louvain-Namur - Centre Hospitalier Universitaire Dinant /ID# 265517
state: Namur
city: Leuven
country: Belgium
facility: UZ Leuven /ID# 265519
state: Vlaams-Brabant
city: Kortrijk
country: Belgium
facility: AZ Groeninge /ID# 265544
state: West-Vlaanderen
city: Liege
country: Belgium
facility: Groupe Sante CHC - Clinique du MontLegia /ID# 265522
city: Sofiya
country: Bulgaria
facility: Hospital Tsaritsa Yoanna /ID# 266235
state: Sofia
city: Sofiya
country: Bulgaria
facility: Medical Center - Doverie /ID# 267050
state: Sofia
city: Sofiya
country: Bulgaria
facility: ACIBADEM City Clinic Diagnostic-Consultative Center /ID# 266239
state: Sofia
city: Plovdiv
country: Bulgaria
facility: Umbal Kaspela /ID# 266234
city: Sofia
country: Bulgaria
facility: 2nd Mhat /ID# 266238
city: Sofia
country: Bulgaria
facility: Acibadem City Clinic Tokuda University Hospital EAD /ID# 267437
city: Sofia
country: Bulgaria
facility: Military Medical Academy Multiprofile Hospital /ID# 267051
city: Varna
country: Bulgaria
facility: Multiprofile Hospital for Active Treatment Sveta Marina /ID# 266237
city: Calgary
country: Canada
facility: University of Calgary /ID# 265524
state: Alberta
city: Edmonton
country: Canada
facility: Gastroenterology and Internal Medicine Research Institute /ID# 265610
state: Alberta
city: London
country: Canada
facility: London Health Sciences Centre - University Hospital /ID# 267298
state: Ontario
city: Vaughan
country: Canada
facility: Toronto Digestive Disease Associates /ID# 267358
state: Ontario
city: Quebec
country: Canada
facility: Diex Recherche Quebec Inc. /ID# 265611
city: Zagreb
country: Croatia
facility: Poliklinika Solmed /ID# 265509
state: Grad Zagreb
city: Osijek
country: Croatia
facility: Poliklinika Borzan d.o.o. /ID# 265503
state: Osjecko-baranjska Zupanija
city: Split
country: Croatia
facility: Klinicki Bolnicki Centar (KBC) Split /ID# 265511
state: Splitsko-dalmatinska Zupanija
city: Rijeka
country: Croatia
facility: Specijalna bolnica Medico Rijeka /ID# 265504
city: Hradec Králové
country: Czechia
facility: Hepato-Gastroenterologie HK /ID# 265387
state: Hradec Kralove
city: Brno
country: Czechia
facility: SurGal Clinic /ID# 265388
state: Jihomoravsky Kraj
city: Prague
country: Czechia
facility: Iscare Klinické Centrum /ID# 265407
state: Praha 9
city: Tallinn
country: Estonia
facility: East Tallinn Central Hospital /ID# 267658
state: Harjumaa
city: Tallinn
country: Estonia
facility: Medicum /ID# 268304
state: Harjumaa
city: Tartu
country: Estonia
facility: Tartu University Hospital /ID# 267656
city: Nice
country: France
facility: Chu de Nice-Hopital L'Archet Ii /Id# 267478
state: Alpes-Maritimes
city: Pessac CEDEX
country: France
facility: Centre Hospitalier Universitaire de Bordeaux /ID# 265721
state: Gironde
city: Toulouse CEDEX 9
country: France
facility: CHU de Toulouse - Hôpital Rangueil /ID# 267479
state: Haute-Garonne
city: Montpellier
country: France
facility: CHU de Montpellier - Hopital Saint Eloi /ID# 265718
state: Herault
city: St-Priest-en-Jarez
country: France
facility: Centre Hospitalier Universitaire de Saint Etienne - Hopital Nord /ID# 265340
state: Loire
city: Vandoeuvre les Nancy
country: France
facility: CHRU de Nancy-Hopital Brabois Adultes /ID# 265703
state: Lorraine
city: Pierre Benite
country: France
facility: Hospices Civils de Lyon - Centre Hospitalier Lyon-Sud /ID# 266851
state: Rhone
city: Nantes
country: France
facility: Clinique Jules Verne /ID# 267480
city: Paris
country: France
facility: Hôpital Saint Antoine /ID# 265725
city: Rennes
country: France
facility: Centre Hospitalier Universitaire de Rennes - Hôpital Pontchaillou /ID# 266848
city: Freiburg
country: Germany
facility: Universitaetsklinikum Freiburg /ID# 265755
state: Baden-Wuerttemberg
city: Mannheim
country: Germany
facility: Universitaetsmedizin Mannheim /ID# 266961
state: Baden-Wuerttemberg
city: Ulm
country: Germany
facility: Universitaetsklinikum Ulm /ID# 266962
state: Baden-Wuerttemberg
city: Erlangen
country: Germany
facility: Universitaetsklinikum Erlangen /ID# 265927
state: Bayern
city: Frankfurt am Main
country: Germany
facility: Markus Krankenhaus /ID# 265938
state: Hessen
city: Frankfurt
country: Germany
facility: Universitaetsklinikum Frankfurt /ID# 266827
state: Hessen
city: Lueneburg
country: Germany
facility: Klinikum Lueneburg /ID# 266886
state: Niedersachsen
city: Ludwigshafen am Rhein
country: Germany
facility: St. Marien- und St. Annastiftskrankenhaus /ID# 265912
state: Rheinland-Pfalz
city: Homburg
country: Germany
facility: Universitaetsklinikum des Saarlandes /ID# 265753
state: Saarland
city: Halle (Saale)
country: Germany
facility: Studiengesellschaft BSF Unternehmergesellschaft /ID# 265751
state: Sachsen-Anhalt
city: Dresden
country: Germany
facility: Universitaetsklinikum Carl Gustav Carus Dresden /ID# 265931
state: Sachsen
city: Leipzig
country: Germany
facility: Eugastro /ID# 266826
state: Sachsen
city: Kiel
country: Germany
facility: Universitaetsklinikum Schleswig-Holstein - Campus Kiel /ID# 265738
state: Schleswig-Holstein
city: Lübeck
country: Germany
facility: Universitaetsklinikum Schleswig-Holstein Campus Luebeck /ID# 267254
state: Schleswig-Holstein
city: Berlin
country: Germany
facility: Charite Universitaetsmedizin Berlin - Campus Mitte /ID# 265752
city: Berlin
country: Germany
facility: DRK Kliniken Berlin - Westend /ID# 265925
city: Berlin
country: Germany
facility: Krankenhaus Waldfriede /ID# 266676
city: Szekszárd
country: Hungary
facility: Clinfan /ID# 267385
state: Tolna
city: Budapest
country: Hungary
facility: Synexus Hungary Clinical Research Centre - Budapest /ID# 267384
city: Budapest
country: Hungary
facility: Semmelweis Egyetem /ID# 267064
city: Budapest
country: Hungary
facility: Semmelweis Egyetem /ID# 267068
city: Szeged
country: Hungary
facility: Szegedi Tudományegyetem /ID# 267386
city: Ballinasloe
country: Ireland
facility: Portiuncula University Hospital /ID# 267771
state: Galway
city: Drogheda
country: Ireland
facility: Our Lady of Lourdes Hospital - Drogheda /ID# 267768
state: Louth
city: Mullingar
country: Ireland
facility: Midland Regional Hospital Mullingar /ID# 267769
state: Westmeath
city: Dublin
country: Ireland
facility: St. Vincent's University Hospital /ID# 267766
city: Dublin
country: Ireland
facility: Beaumont Hospital /ID# 267770
city: Dublin
country: Ireland
facility: Connolly Hospital /ID# 268021
city: Haifa
country: Israel
facility: Rambam Health Care Campus /ID# 267641
state: H_efa
city: Be'er Sheva
country: Israel
facility: Soroka Medical Center /ID# 267235
state: HaDarom
city: Holon
country: Israel
facility: Edith Wolfson Medical Center /ID# 267640
state: HaMerkaz
city: Tel Aviv
country: Israel
facility: Tel Aviv Sourasky Medical Center /ID# 267307
state: Tel-Aviv
city: Monserrato
country: Italy
facility: Azienda Ospedaliero Universitaria di Cagliari - P.O. Duilio Casula /ID# 267287
state: Cagliari
city: San Giovanni Rotondo
country: Italy
facility: Fondazione di Religione e di Culto Casa Sollievo della Sofferenza /ID# 267143
state: Foggia
city: Rozzano
country: Italy
facility: IRCCS Istituto Clinico Humanitas /ID# 265946
state: Lombardia
city: Milan
country: Italy
facility: IRCCS Ospedale San Raffaele /ID# 265951
state: Milano
city: Rome
country: Italy
facility: Azienda Ospedaliera Universitaria Policlinico Tor Vergata /ID# 265935
state: Roma
city: Rome
country: Italy
facility: Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Università Cattolica /ID# 265940
state: Roma
city: Turin
country: Italy
facility: A.O. Ordine Mauriziano di Torino /ID# 267144
state: Torino
city: Negrar
country: Italy
facility: IRCCS Ospedale Sacro Cuore Don Calabria /ID# 265942
state: Verona
city: Catanzaro
country: Italy
facility: Azienda Ospedaliero-Universitaria Renato Dulbecco /ID# 267722
city: Messina
country: Italy
facility: Azienda Ospedaliera Universitaria Gaetano Martino /ID# 267145
city: Busan
country: Korea, Republic of
facility: Inje University Haeundae Paik Hospital /ID# 266380
state: Busan Gwang Yeogsi
city: Busan
country: Korea, Republic of
facility: Dong-A University Medical Center /ID# 266709
state: Busan Gwang Yeogsi
city: Daejeon
country: Korea, Republic of
facility: The Catholic University of Korea, Daejeon St. Mary's Hospital /ID# 265488
state: Daejeon Gwang Yeogsi
city: Dongjak-gu
country: Korea, Republic of
facility: Chungang University Hospital /ID# 266427
state: Seoul Teugbyeolsi
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center /ID# 265489
state: Seoul Teugbyeolsi
city: Daegu
country: Korea, Republic of
facility: Kyungpook National University Chilgok Hospital /ID# 265487
city: Liepaja
country: Latvia
facility: Liepaja Regional Hospital /ID# 267703
city: Riga
country: Latvia
facility: Pauls Stradins Clinical University Hospital /ID# 267705
city: Riga
country: Latvia
facility: Digestive Diseases Center GASTRO /ID# 267707
city: Kaunas
country: Lithuania
facility: Hospital of Lithuanian University of Health Sciences Kaunas /ID# 267695
city: Panevezys
country: Lithuania
facility: Panevezys Republican Hospital /ID# 267709
city: Vilnius
country: Lithuania
facility: Vilnius University Hospital Santaros Klinikos /ID# 267711
city: Tilburg
country: Netherlands
facility: Elisabeth TweeSteden Ziekenhuis /ID# 265729
state: Noord-Brabant
city: Amsterdam
country: Netherlands
facility: Amsterdam UMC, locatie AMC /ID# 268321
state: Noord-Holland
city: Groningen
country: Netherlands
facility: Universitair Medisch Centrum Groningen /ID# 265736
city: Utrecht
country: Netherlands
facility: Universitair Medisch Centrum Utrecht /ID# 265731
city: Lørenskog
country: Norway
facility: Akershus University Hospital /ID# 267642
state: Akershus
city: Alesund
country: Norway
facility: Helse More- og Romsdal HF, Alesund sjukehus /ID# 267632
state: More Og Romsdal
city: Oslo
country: Norway
facility: Oslo Universitetssykehus Ulleval /ID# 267630
city: Bydgoszcz
country: Poland
facility: NZOZ Centrum Medyczne KERmed /ID# 266766
state: Kujawsko-pomorskie
city: Torun
country: Poland
facility: Gastromed Sp. z o.o /ID# 266765
state: Kujawsko-pomorskie
city: Krakow
country: Poland
facility: Malopolskie Centrum Kliniczne /ID# 265943
state: Malopolskie
city: Warsaw
country: Poland
facility: Medical Network Sp.z.o.o. WIP Warsaw IBD Point Profesor Kierkus /ID# 266764
state: Mazowieckie
city: Warszawa
country: Poland
facility: Bodyclinic Sp. z o.o. sp.k. /ID# 265945
state: Mazowieckie
city: Sopot
country: Poland
facility: Endoskopia Sp. z.o.o. /ID# 265934
state: Pomorskie
city: Tychy
country: Poland
facility: H-T Centrum Medyczne Endoterapia /ID# 265937
state: Slaskie
city: Kielce
country: Poland
facility: Polimedica PTG Kielce /ID# 267066
state: Swietokrzyskie
city: Guimaraes
country: Portugal
facility: Unidade Local de Saude do Alto Ave, EPE /ID# 265892
state: Braga
city: Braga
country: Portugal
facility: 2CA-Braga, Hospital de Braga /ID# 265894
city: Coimbra
country: Portugal
facility: Unidade Local de Saude de Coimbra, EPE /ID# 267240
city: Lisboa
country: Portugal
facility: Unidade Local de Saude de Lisboa Ocidental, EPE /ID# 267242
city: Lisboa
country: Portugal
facility: Unidade Local de Saude de Santa Maria, EPE /ID# 266113
city: Viana Do Castelo
country: Portugal
facility: Unidade Local de Saude do Alto Minho, EPE - Hospital de Santa Luzia /ID# 265885
city: Bucharest
country: Romania
facility: Memorial Healthcare International S.R.L. /Id# 267328
state: Bucuresti
city: Bucharest
country: Romania
facility: Spitalul Clinic Colentina /ID# 267208
state: Bucuresti
city: Cluj-Napoca
country: Romania
facility: Clinica Gastro Med SRL /ID# 267204
state: Cluj
city: Timișoara
country: Romania
facility: OncoHelp Association /ID# 267203
state: Timis
city: Belgrade
country: Serbia
facility: Clinical Hospital Center Zvezdara /ID# 265605
state: Beograd
city: Belgrade
country: Serbia
facility: University Clinical Hospital Center "Dr. Dragisa Misovic - Dedinje" /ID# 265607
state: Beograd
city: Belgrade
country: Serbia
facility: Clinical Hospital Center - Bežanijska Kosa /ID# 265604
state: Beograd
city: Leskovac
country: Serbia
facility: Leskovac General Hospital /ID# 265606
state: Jablanicki Okrug
city: Zrenjanin
country: Serbia
facility: General Hospital Djordje Joanovic /ID# 266040
state: Vojvodina
city: Novi Sad
country: Serbia
facility: University Clinical Center Vojvodina /ID# 265603
city: Singapore
country: Singapore
facility: Gastroenterology and Liver Specialist Clinic /ID# 268354
state: Central Singapore
city: Singapore
country: Singapore
facility: Gleneagles Hospital /ID# 268385
state: Central Singapore
city: Singapore
country: Singapore
facility: National University Hospital /ID# 268128
city: Banska Bystrica
country: Slovakia
facility: Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 266064
state: Banskobystricky Kraj
city: Nitra
country: Slovakia
facility: KM Management, spol. s.r.o. /ID# 266070
state: Nitriansky Kraj
city: Prešov
country: Slovakia
facility: Gastro I., s.r.o. /ID# 267159
state: Presovsky Kraj
city: Košice
country: Slovakia
facility: ENDOMED s.r.o /ID# 266068
city: Celje
country: Slovenia
facility: General Hospital Celje /ID# 267699
city: Ljubljana
country: Slovenia
facility: University Medical Centre Ljubljana /ID# 267697
city: Santiago de Compostela
country: Spain
facility: Complejo Hospitalario Universitario de Santiago (CHUS) /ID# 266902
state: A Coruna
city: Seville
country: Spain
facility: Hospital Universitario Virgen Macarena /ID# 266648
state: Sevilla
city: Seville
country: Spain
facility: Hospital Universitario Virgen del Rocio /ID# 266727
state: Sevilla
city: Barcelona
country: Spain
facility: Hospital Clinic de Barcelona /ID# 265415
city: Madrid
country: Spain
facility: Hospital Universitario 12 de Octubre /ID# 265444
city: Madrid
country: Spain
facility: Hospital Universitario La Paz /ID# 265412
city: Pontevedra
country: Spain
facility: Hospital Alvaro Cunqueiro /ID# 266647
city: Valencia
country: Spain
facility: Hospital Universitari i Politècnic La Fe /ID# 265478
city: Bern
country: Switzerland
facility: Intesto /ID# 265728
city: Glasgow
country: United Kingdom
facility: Gartnavel General Hospital /ID# 266407
state: Glasgow City
city: London
country: United Kingdom
facility: Royal Free Hospital /ID# 268065
state: Greater London
city: London
country: United Kingdom
facility: St. George's Hospital /ID# 266335
state: Greater London
city: Oxford
country: United Kingdom
facility: The John Radcliffe Hospital /ID# 266334
state: Oxfordshire
city: Guildford
country: United Kingdom
facility: The Royal Wolverhampton NHS Trust /ID# 268158
state: Surrey
city: Coventry
country: United Kingdom
facility: University Hospital Coventry & Warwickshire NHS Trust /ID# 267128
state: Warwickshire
city: Edinburgh
country: United Kingdom
facility: Western General Hospital, Edinburgh /ID# 266333
city: London
country: United Kingdom
facility: Barts Health NHS Trust /ID# 266410
city: Newcastle upon Tyne
country: United Kingdom
facility: Royal Victoria Infirmary /ID# 268064
Study officials:
affiliation: AbbVie
name: ABBVIE INC.
role: STUDY_DIRECTOR
References: