Clinical trial NCT02068261: Working Memory Training in Adults With Substance Abuse and Executive Function Deficits.
Official title: Computerized Working Memory Training in Adults With Substance Abuse and Executive Function Deficits: A Randomised Controlled Trial.
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE2
Conditions: Substance Abuse
Executive Dysfunction
Anxiety
Depression
Antisocial Personality
Reading Disabilities
Lead sponsor: Örebro Läns Landsting
Sponsor class: OTHER_GOV
First posted: 2014-02-21
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to evaluate the effects of a computerized working memory training program on substance abuse, psychosocial functioning, cognitive performance and psychiatric problems in adults with substance abuse and attention problems.

Detailed description: The primary aim of this study is to examine the effects of 5 weeks of computerized working memory training on substance abuse. Secondary aims are to explore whether effects are mediated by changes in executive functions and/or moderated by personality. Also, effects on measures of psychosocial functioning, depression, anxiety and attention will be explored. Follow-up assessment will be conducted at 6 months post training.

Eligibility criteria: Inclusion Criteria:

* Treatment seeking adults with substance abuse and executive function deficits.

Exclusion Criteria:

* Acute intoxication or abstinence symptoms of any substance.
* Psychosis.

Primary outcomes:
measure: Change from baseline in substance abuse measured with Substance abuse scales in Adult Self Report (ASR; ASEBA).
timeFrame: Baseline and at 25 weeks
Secondary outcomes:
measure: Change from baseline in Adult Self Report (ASR; ASEBA) Attention problems scale.
timeFrame: Baseline and at 25 weeks
measure: Change from baseline in Adult Self Report (ASR; ASEBA) Internalizing index.
timeFrame: Baseline and at 25 weeks
measure: Change from baseline in Adult Self Report (ASR; ASEBA) Externalizing index.
timeFrame: Baseline and at 25 weeks
measure: Change from baseline in Adult Self Report (ASR; ASEBA) Adaptive functioning scales.
timeFrame: Baseline and at 25 weeks
measure: Change from baseline in Executive functioning measured with Behavior Rating Inventory of Executive Function-Adult (BRIEF-A).
timeFrame: Baseline and at 25 weeks
measure: Change from baseline in verbal working memory measured with performance on Digit span.
timeFrame: Baseline and at 25 weeks
measure: Change from baseline in visual working memory measured with performance on Span board.
timeFrame: Baseline and at 25 weeks
measure: Change from baseline in focused attention measured with performance on Conners Continuous Performance Test-II (CCPT-II).
timeFrame: Baseline and at 25 weeks
measure: Change from baseline in vigilance measured with performance on Conners Continuous Performance Test-II (CCPT-II).
timeFrame: Baseline and at 25 weeks
measure: Change from baseline in reading speed measured with performance on Reading speed in Diagnostic Reading and Writing Test (DLS; Swedish version).
timeFrame: Baseline and at 25 weeks
Other outcomes:
Locations:
city: Örebro
country: Sweden
facility: Psychiatric Research Centre
Study officials:
affiliation: Örebro Läns Landsting
name: Lars Kjellin, Docent
role: STUDY_DIRECTOR
References: