Clinical trial NCT06336083: Familial Form of Carotid Web: a Doppler Ultrasound Study
Official title: Family Screening for Internal Carotid Diaphragm Dysplasia (carotid WEB): a Doppler Ultrasound Study
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Carotid Web
Keywords: echography doppler
carotid web
inheritance
Lead sponsor: University Hospital, Toulouse
Sponsor class: OTHER
First posted: 2024-03-28
Enrollment: 90
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: SCREENING

Brief summary: There is no evidence of familial forms of carotid web. The aim of this study is to determine the prevalence of carotid web among relatives of patient with carotid web using carotid doppler ultrasound.

Detailed description: Carotid web are rare, focal dysplasia of the internal carotid artery and a high risk causes of stroke in young adult. Natural history of these dysplasia remains poorly understood. High prevalence of carotid web among Afro-Caribbean population and the similarity between carotid web and fibromuscular dysplasia, suggest existence of genetic factors. But there has been to our knowledge no familial form of carotid web reported. The aim of this study is to determine the prevalence of carotid web among relatives of patients with carotid web using carotid duplex doppler ultrasound.

Researchers aim to test whether carotid web could be detected in relatives of patients with known carotid web, using duplex doppler ultrasound.

This is a pilot, transversal, single-center study performed at Toulouse University Hospital, France. From 30 carotid web cases aged under 65 (patients with previously known Carotid web, symptomatic or not) followed in neurology department, investigators aim to include 60 first-degree relatives younger than 65 years old. Included relatives will underwent carotid duplex doppler ultrasound to detect carotid web. The primary outcome is the prevalence of carotid web among relatives. Secondary outcomes include : Number of families with at least one relative who has been diagnosed with carotid web, number of relatives who has been diagnosed with carotid web per family, clinical characteristics of patients and morphological characteristics of carotid web.

Eligibility criteria: Inclusion Criteria:

Carotid Web index patients:

* Patients with carotid web confirmed by CT angiogram (CTA) of cervical arteries or digital substraction angiogram (DSA).
* At least one first degree relative aged younger than 65 years old.

Relatives patients :

- First degree relatives of patient with diagnosed carotid web.

Exclusion Criteria:

* Persons placed under judicial protection or under another protection status
* Pregnant or breastfeeding woman.

Primary outcomes:
measure: Evaluation of the prevalence of carotid web by doppler ultrasound in first-degree relatives of patients with carotid web.
timeFrame: Inclusion day
Secondary outcomes:
measure: Description of the clinical characteristics of relatives with carotid web and their index case.
timeFrame: Inclusion day
measure: Description of the morphological characteristics of relatives with carotid web and their index case.
timeFrame: Inclusion day
Other outcomes:
Locations:
city: Toulouse
country: France
facility: CHU de Toulouse, Purpan
Study officials:
affiliation: University Hospital, Toulouse
name: Claire VILLEPINTE, MD
role: PRINCIPAL_INVESTIGATOR
References: