Clinical trial NCT05654298: Influence of Ubrogepant and Sumatriptan on the Dermal Blood Flow Response to Histamine, Cinnamaldehyde and Capsaicin
Official title: Influence of Ubrogepant and Sumatriptan on the Dermal Blood Flow Response After a Histamine Skin Prick as Well as After the Topical Application of Cinnamaldehyde and Capsaicin
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Migraine
Lead sponsor: Universitaire Ziekenhuizen KU Leuven
Sponsor class: OTHER
First posted: 2022-12-16
Enrollment: 20
Sex: MALE
Minimum age (years): 18
Maximum age (years): 45
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: BASIC_SCIENCE

Brief summary: The involvement of calcitonin gene-related peptide (CGRP) in the cinnamaldehyde-induced dermal blood flow increase and in the mechanism of action of triptans will be investigated. The capsaicin-induced dermal blood flow will be incorporated as a positive control; histamine skin pricks as a negative control. Changes in dermal blood flow will be measured with laser speckle contrast imaging.


Eligibility criteria: Inclusion Criteria:

1. Subject is a white male ≥ 18 and ≤ 45 years of age at the time of screening.
2. Subject is a nonsmoker for at least 6 months prior to the study start.
3. Subject has a body mass index ≥ 18 and ≤ 30 kg/m2.
4. Subject has a clear increase in histamine-induced dermal blood flow.
5. Subject has an increase in capsaicin- and cinnamaldehyde-induced dermal blood flow of at least 100% as determined during the screening visit.
6. Subject is judged to be in good health on the basis of medical history, physical examination and vital signs.
7. Subject understands the procedures and agrees to comply with them for the entire length of the study by giving written informed consent.

Exclusion Criteria:

1. Subject has excessive hair growth on the volar surface of the forearm.
2. Subject has a past or present history of diffuse dermatological conditions including eczema, scleroderma, psoriasis, urticaria, dermatographism and dermatitis.
3. Subject has any abnormality on the skin of the forearm, possibly interfering with the study assessments including tattoos, keloids, tumors, ulcers, burns, flaps and grafts.
4. Subject cannot avoid excessive tanning (any exposure to sunlight or a tanning bed which would cause a sunburn reaction) throughout the study and cannot cover the forearms 24 hours before and after each study visit.
5. Subject currently uses lotions, oils, depilatory preparations, makeup or other topical treatments on the arms and on a regular basis which cannot be discontinued for the duration of the study; subject has used any topical treatments within 7 days of the start of the study.
6. Subject has a past or present history of (symptomatic) asthma.
7. Subject has a history of severe allergic reactions to food or drugs or adverse experiences of a serious nature related to the administration of either a marketed or investigational drug, including histamine, cinnamaldehyde, capsaicin, ubrogepant or sumatriptan.
8. Subject currently uses any prescription or nonprescription drugs on a regular basis which cannot be discontinued for the duration of the study; subject has used any prescription or nonprescription medication within 14 days or 5 half-lives of the start of the study.
9. Subject is a habitual and heavy consumer of coffee or caffeinated beverages (more than approximately 4 cups of tea, coffee or cola per day) at the time of the study. Subjects who have reduced their consumption to ≤ 4 cups per day at least 1 week prior to enrollment may participate. Subjects who cannot refrain from caffeinated beverages 24 hours before the study visit.
10. Subject is unable to refrain from drinking alcohol 24 hours prior to histamine application, is currently a regular user (including "recreational use") of any illicit drugs, or has a history of drug (including alcohol) abuse. A drug screen will include amphetamines/ methamphetamines, methylenedioxymethamphetamine, benzodiazepines, barbiturates, cocaine, cannabis, tricyclic antidepressants, methadone and opiates.
11. Subject cannot refrain from being around secondhand smoke 24 hours prior to histamine application or uses nicotine-containing products. Ex-smokers should have ceased smoking at least 6 months prior to screening.
12. Subject has any of the following vital sign measurements at screening: heart rate ≤ 40 or ≥ 100 beats/min, diastolic blood pressure ≤ 50 or ≥ 89 mmHg and/or systolic Blood Pressure ≤ 90 or ≥ 139 mmHg.
13. Subject has been involved in testing an investigational drug in another clinical study within the last 4 weeks or 5 half-lives.
14. Subject has evidence of a clinically significant active infection, fever of 38°C or above at the time of the study visits.
15. Subject has a history or current cardiovascular (e.g. myocardial infarction, ischemic heart disease, coronary vasospasm, peripheral vascular disease, mild or severe hypertension or mild uncontrolled hypertension and patients who show symptoms of ischemic heart disease,), respiratory, hepatic (e.g. severe liver insufficiency), renal (e.g. severe renal impairment), gastrointestinal or neurological (e.g. cerebrovascular accident or transient ischemic attacks) disorders capable of significantly altering the absorption, metabolism or elimination of drugs.
16. Subject is in a situation or has a condition, which, in the opinion of the investigator, may interfere with safe and optimal participation in the study.
17. Subject has a history of any illness or disorder, which, in the opinion of the investigator, might confound the results of the study.

Primary outcomes:
measure: Change in Dermal Blood Flow induced by topical application of cinnamaldehyde
timeFrame: AUC(0-60minutes)
measure: Change in Dermal Blood Flow induced by topical application of capsaicin
timeFrame: AUC(0-60minutes)
measure: Change in Dermal Blood Flow induced by histamine Skin Prick Test
timeFrame: AUC(0-60minutes)
Secondary outcomes:
Other outcomes:
Locations:
city: Leuven
country: Belgium
facility: Center for Clinical Pharmacology
Study officials:
References: