Clinical trial NCT03166670: Parasitic Causes of Secretory Diarrhea in Children and Chronically Ill Adult.
Official title: Parasitic Causes of Secretory Diarrhea in Children and Chronically Ill Adult.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Diarrhea, Secretory
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2017-05-25
Enrollment: 100
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: -Children presented with secretory diarrhea(acute watery diarrhea) attend to out clinic lab of Assiut University pediatric hospital or admitted in pediatric hospital(gastroenterology department) during the study period.

2-adult patients having acute watery diarrhea attend to out clinic labs of Assiut University hospital or admitted in gastroenterology, nephrology and oncology department of hospital during the study period.

Brief summary: Diarrhea is one of the most common reasons for people to seek medical advice - but it can range from being a mild, temporary condition, to be life threading condition. It is estimated that there are 2 billion cases of diarrheal disease every year globally, and that 1.9 million children below the age of 5 years, mostly in developing countries, die annually.

Detailed description: Secretory diarrhea has many causes as infection with bacteria, viruses or protozoa. It results from increased chloride secretion, decreased sodium absorption, or increased mucosal permeability . Parasitic pathogens induce Secretory diarrhea as they infect and damage the absorptive villus tips, leaving Secretory crypts unbalanced, to cause net secretion and diarrhea. Parasitic causes include Cryptosporidium parvum or hominis ,Capillaria philippinensis and Giardia lamblia. Cryptosporidiosis is also recognized as a cause of prolonged and persistent diarrhea in children and persons with impaired immunity. The disease is transmitted via the fecal-oral route from infected hosts. It can be also transmitted following animal contact, ingestion of water (mainly during swimming), or through food. Cryptosporidium has emerged as the most frequently recognized cause of water-associated outbreaks of gastroenteritis. This is because of the oocyst stage in its life cycle; Cryptosporidium can resist disinfection, including chlorination, and can survive for a prolonged period in the environment.

Eligibility criteria: Inclusion Criteria:

1. Children presented with secretory diarrhea(acute watery diarrhea) attend to out clinic lab of Assiut University pediatric hospital or admitted in pediatric hospital(gastroenterology department) during the study period.
2. adult patients having acute watery diarrhea attend to out clinic labs of Assiut University hospital or admitted in gastroenterology, nephrology and oncology department of hospital during the study period.

Exclusion Criteria:

1. viral and bacterial causes of diarrhea
2. Patients who were already diagnosed as intestinal inflammatory disease as irritable bowel syndrome.
3. Autoimmune conditions, such as ulcerative colitis, Crohn's disease and coeliac disease.

Primary outcomes:
measure: percentage of patients with positive stool analysis for cryptosporidium
timeFrame: 2 days
Secondary outcomes:
Other outcomes:
Locations:
city: Assiut
country: Egypt
facility: Heba gamal rashed
Study officials:
affiliation: Assuit University, Faculty of medicine
name: Asmaa M Abd elaziz, MD
role: PRINCIPAL_INVESTIGATOR
References:
citation: Pawlowski SW, Warren CA, Guerrant R. Diagnosis and treatment of acute or persistent diarrhea. Gastroenterology. 2009 May;136(6):1874-86. doi: 10.1053/j.gastro.2009.02.072. Epub 2009 May 7.