Clinical trial NCT02431871: Sequelae of Developmental Dysplasia of the Hip
Official title: Structural and Functional Sequelae of Developmental Dysplasia of the Hip
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Developmental Dysplasia of the Hip
Hip Dysplasia
Keywords: Developmental dysplasia of the hip
Hip dysplasia
Occlusal defect
Lead sponsor: University of Oulu
Sponsor class: OTHER
First posted: 2015-05-01
Enrollment: 340
Sex: ALL
Minimum age (years): 10
Maximum age (years): 30
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: 10-30 years old patientstreated for DDH in early childhood in Oulu University Hospital

Brief summary: The aim of this study is to assess long term effects of developmental dysplasia of the hip (DDH) to overall health and quality of life later in life. We compare hip radiographs, hip symptoms, clinical examination, head asymmetry, dental examination and intraoral scans of 170 children and young adults treated for DDH in their childhood with age and sex matched controls.

Detailed description: Developmental dysplasia of the hip (DDH) is the most common musculoskeletal disorder in infancy. However there are few reports of long term effects of successfully treated DDH. Incidence of DDH in neonatal period is approximately 1-10/1000 depending on screening protocols used, the age of the infant during screening and which ultrasonographic findings are considered normal and which DDH. The prevalence of hip dysplasia in adult population is grossly 4 % when using Wibergs Centre-Edge (CE) ≤ 20° as definition of dysplasia. It is still unclear, what is the relation between adult acetabular dysplasia and developmental dysplasia in children. Hip dysplasia overall is a major contributing factor in hip osteoarthrosis and total hip replacement in young adults.

The aim of this study is to assess long term effects of developmental dysplasia of the hip to overall health and quality of life later in life. We compare hip radiographs, hip symptoms, clinical examination, head asymmetry, dental examination and intraoral scans of 170 children and young adults treated for DDH in their early childhood with age and sex matched controls.

Eligibility criteria: Inclusion Criteria for person treated for DDH:

* DDH has been diagnosed by clinical examination, ultrasound examination or by radiological examination and treatment begun before age of 1,5 years.
* Treated in Oulu University Hospital

Exclusion Criteria:

* neurological or developmental condition which can influence hip development such as cerebral palsy or spina bifida
* other significant congenital anomalies of musculoskeletal system such as club feet

Primary outcomes:
measure: Wibergs Centre-Edge Angle
timeFrame: 10 - 30 years after DDH has been treated
Secondary outcomes:
measure: The Copenhagen Hip and Groin Outcome Score (HAGOS)
timeFrame: 10 - 30 years after DDH has been treated
measure: Oral Heath Impact Profile
timeFrame: 10 - 30 years after DDH has been treated
measure: Occlusal asymmetries
timeFrame: 10 - 30 years after DDH has been treated
measure: Presence of facial asymmetry
timeFrame: 10 - 30 years after DDH has been treated
Other outcomes:
measure: Hip deformity
timeFrame: 10 - 30 years after DDH has been treated
measure: Asymmetry in clinical hip examination
timeFrame: 10 - 30 years after DDH has been treated
Locations:
city: Oulu
country: Finland
facility: University of Oulu; Oulu University Hospital
Study officials:
affiliation: University of Oulu
name: Juhana Leppilahti, Professor
role: PRINCIPAL_INVESTIGATOR
affiliation: University of Oulu, Oulu University Hospital, MRC Oulu
name: Marita Valkama, Ph.D., M.D
role: STUDY_DIRECTOR
affiliation: University of Oulu, MRC Oulu
name: Virpi Harila, Ph.D.
role: STUDY_DIRECTOR
References: