Clinical trial NCT02177383: Action of Essential Fatty Acids on the Expression of Antioxidant Genes and Athletic Performance
Official title: Scientific Basis of the Action of Foods Rich in Essential Fatty Acids on the Expression of Antioxidant Genes and Athletic Performance
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Oxidative Stress
Exercise
Training Season
Antioxidant Capabilities
Athletic Performance
Lead sponsor: University of the Balearic Islands
Sponsor class: OTHER
Collaborators: name: Instituto de Salud Carlos III
First posted: 2014-06-27
Enrollment: 15
Sex: MALE
Minimum age (years): 16
Maximum age (years): 35
Standard ages: CHILD
ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: There are conflicting evidences of the effects of dietary supplementation with polyunsaturated fatty acids (PUFAs) on athletic performance. The investigators working hypothesis is based on the polyunsaturated fatty acids, given its pro-oxidative character and also by its action on transcription factors can modulate the antioxidant response and oxidative damage induced by physical activity.The overall objective of the study is to establish situations improving athletic performance and study the oxidative balance by manipulation of feeding patterns and consumption of nutritional supplements and investigate the involved mechanisms.

Detailed description: There are conflicting evidences of the effects of dietary supplementation with polyunsaturated fatty acids (PUFAs) on athletic performance. The described effects of PUFAs on the fat metabolism may be modulated by the expression and activity of transcription factor genes, suppressing or expressing genes associated with the synthesis and oxidation of fats and in oxidative stress and inflammation.

The investigators' working hypothesis is based on the polyunsaturated fatty acids, given its pro-oxidative character and also by its action on transcription factors can modulate the antioxidant response and oxidative damage induced by physical activity.

In the field of professional sports and leisure use of food and / or antioxidants in the belief that these elements prevent muscle damage is very established. Most studies in athletes supplemented with antioxidant nutrients revealed no significant effects on physical performance, but it has shown that supplements protect against tissue damage induced by exercise. Recent studies have reported that over 35% of the Spanish people eat diets low or very low quality, which is clearly shown that over 10% of Spaniards have poor intakes (\<2/3 IDR) riboflavin (men) , folate (women), vitamin C, vitamin A, vitamin D and vitamin E.

The overall objective of the study is to establish situations improving athletic performance and study the oxidative balance by manipulation of feeding patterns and consumption of nutritional supplements and investigate the involved mechanisms. The aim of this study is to establish scientific basis for design functional foods improving athletic performance and health and avoiding the negative consequences of the oxidative damage induced by overexertion.

Eligibility criteria: Inclusion Criteria:

* Ages eligible for study: 16 to 35 years
* Genders eligible for study: Male
* Equilibrate diet
* Physical activity of 1-2 hours daily 5-7 days weekly.
* Body mass index (19-25 kg/m2)

Exclusion Criteria:

* Smokers

Primary outcomes:
measure: DHA incorporation in erythrocyte cellular membranes
timeFrame: Baseline, week 8
Secondary outcomes:
measure: DHA on oxidative stress
timeFrame: Baseline, week-8 (pre- and post-exercise)
measure: DHA on inflammation
timeFrame: Baseline, week-8 (pre- and post-exercise)
Other outcomes:
Locations:
city: Palma de Mallorca
country: Spain
facility: University of Balearic Islands
state: Balearic Islands
Study officials:
References:
citation: Capo X, Martorell M, Sureda A, Llompart I, Tur JA, Pons A. Diet supplementation with DHA-enriched food in football players during training season enhances the mitochondrial antioxidant capabilities in blood mononuclear cells. Eur J Nutr. 2015 Feb;54(1):35-49. doi: 10.1007/s00394-014-0683-2. Epub 2014 Mar 19.
citation: Martorell M, Capo X, Sureda A, Tur JA, Pons A. Effects of docosahexaenoic acid diet supplementation, training, and acute exercise on oxidative balance in neutrophils. Appl Physiol Nutr Metab. 2014 Apr;39(4):446-57. doi: 10.1139/apnm-2013-0331. Epub 2013 Nov 4.
citation: Capo X, Martorell M, Sureda A, Tur JA, Pons A. Effects of dietary Docosahexaenoic, training and acute exercise on lipid mediators. J Int Soc Sports Nutr. 2016 Apr 5;13:16. doi: 10.1186/s12970-016-0126-y. eCollection 2016.