Clinical trial NCT02646605: Depression Amongst HIV Positive Patients in Lilongwe
Official title: Prevalence of Depression Amongst HIV Positive Patients Attending ART Clinic at Lighthouse Clinic, Lilongwe
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: HIV
AIDS
Keywords: Depression
AIDS
HIV
Lead sponsor: University of North Carolina, Chapel Hill
Sponsor class: OTHER
Collaborators: name: Fogarty AIDS international training research program
First posted: 2016-01-05
Enrollment: 206
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Men and women accessing HIV care at Lighthouse clinic, Lilongwe, Malawi will be invited to participate.

Brief summary: Quantitative, validated tools of depression screening will be used to collect data to determine the prevalence of depression and its association with antiretroviral (ARV) adherence amongst HIV positive patients attending ART clinic at Lighthouse Lilongwe, Malawi.

Detailed description: Preliminary data on prevalence and associations will be collected from 200 HIV positive adult men and women attending ART clinic at the Lighthouse in Lilongwe, Malawi. Quantitative, validated tools of depression screening will be used. A short structured demographic questionnaire will be used to collect demographic data. For depression, a Patient Health Questionnaire (PHQ) will be used while alcohol use will be assessed by Alcohol Use Disorders Identification Test (AUDIT) screening tool. The data collected will provide baseline data planning, program development and evaluation, and to promote comprehensive care provision for the people living with AIDS attending ART clinics in Malawi.

Eligibility criteria: Inclusion Criteria:

* 18 years and above
* HIV positive men and women accessing care at LH
* Both ART naïve and on ART
* Registered with LH
* Receiving primary care and/ or ART from LH

Exclusion Criteria:

* Too sick to comprehend consent or requiring admission
* Known mentally ill patient on psychiatric drugs
* Less than 18 years old

Primary outcomes:
measure: Prevalence of depression amongst HIV positive patients attending ART clinic at Lighthouse Lilongwe, Malawi
timeFrame: enrollment
Secondary outcomes:
Other outcomes:
Locations:
city: Lilongwe
country: Malawi
facility: Lighthouse Clinic
Study officials:
affiliation: University of North Carolina, Chapel Hill
name: Mina Hosseinipour, MD, MPH
role: PRINCIPAL_INVESTIGATOR
References:
citation: Malawi Demographic Profile 2012
citation: Mwale M.C. et al (2006) The Prevalence Of Psychological Distress And Associated Factors Among People Living With Aids Attending Antiretroviral Therapy Clinics In Mzuzu, Malawi: A Cross Sectional Descriptive study. Accessed on 09 June 2012 from www.medcol.mw/mph/.../Charles%20M%20%20Mwale.pdf
citation: Guilbert JJ. The world health report 2002 - reducing risks, promoting healthy life. Educ Health (Abingdon). 2003 Jul;16(2):230. doi: 10.1080/1357628031000116808. No abstract available.
citation: Rochon PA, Mashari A, Cohen A, Misra A, Laxer D, Streiner DL, Dergal JM, Clark JP, Gold J, Binns MA. Relation between randomized controlled trials published in leading general medical journals and the global burden of disease. CMAJ. 2004 May 25;170(11):1673-7. doi: 10.1503/cmaj.1031006.
citation: World Health Organisation. (2005). Promoting Mental Health: concepts, emerging evidence, practice: report of the world health organisation, Dept of Mental Health and Substance Abuse in collaboration with the Victorian Health Promotion Foundation & the University of Melbourne. Geneva: World Health Organisation.