louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05901311: A Study of [14C]-LY3537982 in Healthy Participants
Official title: A Phase I, Open-label, Two-part Study of the Absorption, Metabolism, Excretion, and the Absolute Bioavailability of [14C]-LY3537982 in Healthy Adult Subjects
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE1
Conditions: Healthy
Lead sponsor: Eli Lilly and Company
Sponsor class: INDUSTRY
Collaborators: name: Loxo Oncology, Inc.
First posted: 2023-06-13
Enrollment: 16
Sex: ALL
Minimum age (years): 18
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The main purpose of this study is to conduct blood tests to measure how much LY3537982 is in the bloodstream and how the body handles and eliminates LY3537982 in healthy participants. This study will involve a single dose of 14C radiolabeled LY3537982. This means that a radioactive tracer substance, C14, will be incorporated into the study drug LY3537982 to investigate the study drug and its breakdown products and to find out how much of these passes from blood into urine, feces and expired air. The study will also evaluate the safety and tolerability of LY3537982. The study will be conducted in two parts. The study will last up to 71 days and 61 days for part 1 and 2, respectively.


Eligibility criteria: Inclusion Criteria:

* Male and female participants in good health, determined by no clinically significant findings from medical history, physical examination as assessed by the investigator.
* Have a body mass index within the range 18.5 to 32.0 kilograms per meter squared (kg/m²)
* Female participants of non-childbearing potential and male participants who follow standard contraceptive methods.

Exclusion Criteria:

* History or presence of any diseases or conditions of clinical significance by the Investigator (or designee) and/or Sponsor
* Known ongoing alcohol and/or drug abuse within 2 years prior to Screening
* History of significant hypersensitivity, intolerance, or allergy to any drug compound, food, or other substance, unless approved by the Investigator

Primary outcomes:
measure: Pharmacokinetics (PK): Fraction of Dose Excreted in Urine (Feur)
timeFrame: Predose on day 1 up to postdose on day 21 (Part 1)
measure: PK: Cumulative Feur
timeFrame: Predose on day 1 up to postdose on day 21 (Part 1)
measure: PK: Fraction of Dose Excreted in Feces (Fefeces)
timeFrame: Predose on day 1 up to postdose on day 21 (Part 1)
measure: PK: Cumulative Fefeces
timeFrame: Predose on day 1 up to postdose on day 21 (Part 1)
measure: PK: Fraction of Dose Excreted in Expired Air (Feair)
timeFrame: Predose on day 1 up to postdose on day 21 (Part 1)
measure: PK: Absolute Bioavailability (F) of LY3537982
timeFrame: Predose on day 1 up to postdose on day 9 (Part 2)
Secondary outcomes:
Other outcomes:
Locations:
city: Madison
country: United States
facility: Labcorp Clinical Research Unit Inc.
state: Wisconsin
Study officials:
affiliation: Loxo Oncology, Inc.
name: Yingying Guo-Avrutin, MD, PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT00386711: A Study on Improving Detection and Management of Suicide Risk Among Depressed Patients in Primary Care
Official title: A Study on Improving Detection and Management of Suicide Risk Among Depressed Patients in Primary Care
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: PHASE1
Conditions: Depression
Suicide
Keywords: suicide
depressed patients
primary care
Lead sponsor: Nanjing Medical University
Sponsor class: OTHER
First posted: 2006-10-12
Enrollment: 2160
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: improve detection and management of suicide risk among depressed patients in primary care

Detailed description: After intervention of training on the identification and management of depression and suicide risk in primary health care professionals, the ability of detection and management of suicide risk among depressed patients in primary care is expected to be improved compared to baseline evaluation.

Eligibility criteria: Inclusion Criteria:

* consecutive outpatient

Exclusion Criteria:

* severe physical conditions

Primary outcomes:
measure: Kappa of diagnostic consistency
Secondary outcomes:
measure: ratio of optimal managment
Other outcomes:
Locations:
city: Nanjing
country: China
facility: Nanjing Brain Hospital
state: Jiangsu
Study officials:
affiliation: Nanjing Brain Hospital
name: SHUTAO ZHAI, DOCTOR
role: STUDY_DIRECTOR
References:
Clinical trial NCT06648811: The Effect of Kinesio Tape on Pain Management in Laparoscopic Gynecological Surgeries.
Official title: The Effect of Kinesio Tape on Pain Management in Laparoscopic Gynecological Surgeries: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Gynecological Laparoscopy
Lead sponsor: Mersin University
Sponsor class: OTHER
First posted: 2024-10-18
Enrollment: 54
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Kinesio tapes have been used in medicine to reduce pain in various situations. It is an easy applicable and effective tape. The possible affect of this tape will be assessed in patients undergoing gynecological laparoscopic surgeries.

Detailed description: Kinesio tape is frequently used for pain palliation in medicine including orthopedics, physical therapy and rehabilitation, and dentistry. Recent studies show that it alleviates the amount of postoperative perceived pain in obstetrics and general surgery. In our study, we plan to contribute to the medical literature by studying its effect on pain palliation in patients undergoing laparoscopic gynecological surgery.

Eligibility criteria: Inclusion Criteria:

* being older than 18 years old female gender benign gynecologic conditions patients who underwent laparoscopic surgery patients who do not have any predisposing factors that aggreviate pain no history of malignancy no prior abdominal surgery patients who do not regularly take antiinflammatory medication patients who give permission to participate

Exclusion Criteria:

* being younger than 18 years old non-female gender having malignancies patients who underwent laparatomy patients with predisposing factors that aggrevate pain having prior abdominal surgery patients taking regular antiinflammatory medications who do not want to participate

Primary outcomes:
measure: Amount of perceived pain
timeFrame: 36 hours from the operation
Secondary outcomes:
Other outcomes:
Locations:
city: Mersin
country: Turkey
facility: Mersin University
city: Mersin
country: Turkey
facility: Mersin University
Study officials:
References:
Clinical trial NCT02587728: Carpal Tunnel/Amyloidosis Blood Sample Study
Official title: Collection of Peripheral Blood Samples From Patients With Carpal Tunnel Syndrome for Laboratory Screening of Amyloidosis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Carpal Tunnel Syndrome
Amyloidosis
Lead sponsor: University of Miami
Sponsor class: OTHER
First posted: 2015-10-27
Enrollment: 10
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients within 24 months of confirmed diagnosis of Carpal Tunnel Syndrome

Brief summary: Carpal tunnel is an early manifestation of amyloidosis in a significant minority of patients. This specimen collection protocol will allow the investigators to screen patients with carpal tunnel syndrome for amyloidosis.

Detailed description: The investigators propose to assess a high risk population of patients, those with carpal tunnel syndrome, and systematically assess them for Amyloid Light-chain (AL) amyloidosis and Transthyretin-Related Amyloidosis (ATTR) with simple laboratory blood tests. The combination of serum immunofixation electrophoresis together with serum free light chain (FLC) assay approaches 100% sensitivity for identifying the monoclonal protein underlying the illness in patients with AL amyloidosis. In addition to this, testing for transthyretin gene mutations will allow the investigators to identify patients with ATTR. The investigators believe this simple screening panel (serum immunofixation and serum FLC assay and transthyretin mutation analysis) may allow the investigators to identify patients early in the course of their disease, at which point the investigators can intervene with effective treatment and spare patients a significant amount of morbidity and mortality.

Eligibility criteria: Inclusion Criteria:

* 1. Patients with diagnosed carpal tunnel syndrome based on Electromyography (EMG) results.
* 2. Patients with electrographic confirmation of median neuropathy at the wrist
* 3. Age ≥18 years
* 4. Ability to understand and willingness to sign a written informed consent document.

Exclusion Criteria:

* 1. Patients receiving hemodialysis
* 2. Known amyloidosis

Primary outcomes:
measure: Number of Participants Identified with Amyloidosis
timeFrame: Up to 5 years
Secondary outcomes:
Other outcomes:
Locations:
city: Miami
country: United States
facility: University of Miami
state: Florida
Study officials:
affiliation: University of Miami
name: James Hoffman, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03115528: Difference in the Estimation of Prognosis
Official title: What is the Difference in the Estimation of Prognosis of Advanced Cancer Patients Between Medical Oncologist, Gynecological Oncologists, and Palliative Care Physicians?
Study type: OBSERVATIONAL
Overall status: WITHDRAWN
Conditions: Malignant Neoplasms of Independent (Primary) Multiple Sites
Keywords: Malignant neoplasms of independent (primary) multiple sites
Medical oncologists
Palliative care physicians
Questionnaire
Survey
Lead sponsor: M.D. Anderson Cancer Center
Sponsor class: OTHER
First posted: 2017-04-14
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Medical oncologists and palliative care physicians from UT MD Anderson Cancer Center

Brief summary: Objectives:

Primary Objective:

The primary objective is to identify the difference in the estimation of prognosis of advanced cancer patients between medical oncologists, gynecological oncologists, and palliative care physicians

Detailed description: The goal of this research study is to identify the difference in the estimation of prognosis of advanced cancer patients between medical or gynecological oncologists, and palliative care physicians. Up to 140 patients will be enrolled in this study.

Eligibility criteria: Inclusion Criteria:

1. Medical oncologists or gynecological who referred patients to the palliative care team; Palliative Care physicians to whom the patients were referred; Patients with locally advanced, metastatic, or, not curable cancer.
2. 18 years old or older

Exclusion Criteria:

N/A

Primary outcomes:
measure: Estimation of Patient Overall Survival by Oncologists and by Palliative Care Physicians per Estimation of Prognosis Questionnaire
timeFrame: 6 weeks
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: M.D. Anderson Cancer Center
name: Angelique N. Wong, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00750828: Gingival Wetness and Gingival Crevicular Fluid Volume in Patients With Dry Mouth
Official title: Gingival Wetness and Gingival Crevicular Fluid Volume in Patients With Dry Mouth
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Xerostomia
Sjogren's Syndrome
Keywords: Saliva
Sjögren's Syndrome
GCF
Oral Mucosal Wetness
Lead sponsor: Hacettepe University
Sponsor class: OTHER
First posted: 2008-09-11
Enrollment: 28
Sex: FEMALE
Minimum age (years): 46
Maximum age (years): 56
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: The data for this study were taken from 28 subjects at the Department of Periodontology, Hacettepe University from 2004 to 2007. The study group consisted of 14 patients with dry mouth complaints. All of them had the diagnosis of Sjögren's syndrome and ten of them were on therapy for sicca symptoms.

Fourteen randomly selected age-matched systemically healthy females were also included as a control group

Brief summary: The investigators questioned whether patients with dry mouth complaints display any reduction in residual saliva coating the gingiva and other selected mucosal surfaces. We further intended to test the hypothesis that Gingival Crevicular Fluid volume in patients with dry mouth could be different from that of control subjects. Correlations between gingival/mucosal wetness; and unstimulated whole salivary flow rate or minor salivary gland secretion rates and the correlations between clinical periodontal status and salivary measures were also attempted.


Eligibility criteria: Inclusion Criteria:

* For test group dry mouth complaints and with a diagnosis ofSjogren's Syndrome

Exclusion Criteria:

* Other medical problems that effect salivary glands

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Department of Periodontology, Faculty of Dentistry, Hacettepe University,
Study officials:
affiliation: Hacettepe University Faculty of Dentistry Department of Periodontology
name: Burak Demiralp, DDS PhD
role: STUDY_DIRECTOR
References:
Clinical trial NCT00831428: Screening Scottish Swimmers for Asthma and Rhinitis
Official title: A Pilot Study to Identify the Prevalence of Exercise- Induced Asthma and Rhinitis in Scottish Swimmers, Using Mannitol Challenge as a Screening Tool.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Asthma
Rhinitis
Keywords: asthma
rhinitis
swimmers
mannitol
Lead sponsor: University of Dundee
Sponsor class: OTHER
First posted: 2009-01-29
Enrollment: 97
Sex: ALL
Minimum age (years): 11
Maximum age (years): 23
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The Scottish national and district swimming teams

Brief summary: The Scottish National and District swimming teams will be screened for asthma and rhinitis using both mannitol challenge and sport-based exercise challenge.


Eligibility criteria: Inclusion Criteria:

* member of the Scottish national and district swimming team
* informed consent obtained

Exclusion Criteria:

* pregnant, lactating or planning to become pregnant
* concomitant use of medicines (prescribed, over-the-counter or herbal) that may interfere with the trial.
* any clinically significant medical condition, as deemed by the clinical investigators, which may endanger the health of the participant or jeopardise the protocol.
* inability to comply with the protocol.

Primary outcomes:
measure: Tidal Nitric Oxide
timeFrame: This test will be performed prior to entering the pool, and on exiting the pool
Secondary outcomes:
measure: Mannitol Challenge
timeFrame: This test will be performed once on a district and once on a national squad training day
measure: Sport-based Challenge
timeFrame: This test will be performed once on a district and once on a national squad training day
measure: Nasal Nitric Oxide
timeFrame: This test will be performed prior to entering the pool, and on exiting the pool
measure: Skin Prick Test
timeFrame: This test will be performed once on a district and once on a national squad training day
measure: Mini Nasal Lavage
timeFrame: This test will be performed prior to entering the pool, and on exiting the pool
Other outcomes:
Locations:
city: Stirling
country: United Kingdom
facility: The national swimming academy in Stirling
state: Stirlingshire
Study officials:
affiliation: Asthma and Allergy Research Group
name: Karine L Clearie, MBBS, MRCP
role: PRINCIPAL_INVESTIGATOR
affiliation: Asthma and Allergy Research Group
name: Brian J Lipworth, MBchB
role: STUDY_DIRECTOR
References:
citation: Clearie KL, Williamson PA, Vaidyanathan S, Short P, Goudie A, Burns P, Hopkinson P, Meldrum K, Howaniec L, Lipworth BJ. Disconnect between standardized field-based testing and mannitol challenge in Scottish elite swimmers. Clin Exp Allergy. 2010 May;40(5):731-7. doi: 10.1111/j.1365-2222.2010.03461.x. Epub 2010 Mar 1.
Clinical trial NCT06938828: Treatment of Patients With Neck Pain After a Commuting Accident
Official title: Physiotherapy in the Treatment of Patients With Neck Pain After a Commuting Accident; a Retrospective Cohort Study
Study type: OBSERVATIONAL
Overall status: ACTIVE_NOT_RECRUITING
Conditions: Cervical Injury Spine
Keywords: neck pain
physiotherapy
accidents in itinere
Incapacity for work
Lead sponsor: Universidad Católica San Antonio de Murcia
Sponsor class: OTHER
First posted: 2025-04-22
Enrollment: 204
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who have suffered a traffic accident while traveling to or from work between 2022 and 2024.

Brief summary: Introduction. Neck pain is one of the main causes of incapacity for work. The economic impact of neck pain is considerable due to the cost of medical treatment and physiotherapy. Accidents in itinere, those that occur on the way between home and the workplace, can cause pain and functional impairment.

Objective. To analyze the relationship between the time off work following accidents on the way to and from work and the type of treatment received.

Material and method. Multicenter retrospective cohort study. Data will be collected from 146 patients. The primary variable of the study will be the time on sick leave (in days), with the type of intervention received (manual therapy or not) being the dependent variable. The secondary variables, estimated as modifying or confounding, will be the intensity of the pain (visual analog scale), sex, age, occupational cervical strain, type of contract (salaried/self-employed) and the number of physiotherapy sessions received.


Eligibility criteria: Inclusion Criteria:

* Patients of both sexes
* Persons aged 18 to 65
* Patients with a medical diagnosis of neck pain secondary to traffic accidents while commuting
* Persons without a medical diagnosis of another associated pathology
* Patients whose accident occurred between 2022 and 2024.

Exclusion Criteria:

* Patients who have received physiotherapy treatment at another centre during the process
* Patients who requested voluntary discharge for whatever reason.

Primary outcomes:
measure: Measurement of time off work
timeFrame: Screening visit
Secondary outcomes:
measure: Measurement of type of intervention received
timeFrame: Screening visit
measure: Measurement of pain intensity at the time of medical discharge
timeFrame: Screening visit
measure: Measurement of the number of physiotherapy sessions received
timeFrame: Screening visit
measure: Measurement of the type of employment contract of the patients
timeFrame: Screening visit
measure: Measuring the age of the patients
timeFrame: Screening visit
measure: Measurement of patients' occupational cervical strain
timeFrame: Screening visit
measure: Measuring the gender of patients
timeFrame: Screening visit
Other outcomes:
Locations:
city: Murcia
country: Spain
facility: Universidad Católica San Antonio de Murcia
Study officials:
References:
Clinical trial NCT03142828: Implant Healing Abutment and Chlorhexidine
Official title: Effect of the Application of Chlorhexidine in the Pillars of Implant Healing to Prevent Plate Accumulation. Controlled Random Blind Clinical Study.
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE4
Conditions: Periimplantitis
Keywords: chlorhexidine, dental implant, in-situ drug delivery,
Lead sponsor: Universidad de Murcia
Sponsor class: OTHER
First posted: 2017-05-05
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: After the first week, the healling abutment will be randomly distributed in a test group with application of chlorhexidine gel or a control group without the application of the chlorhexidine gel.
Primary purpose: TREATMENT

Brief summary: The work hyposesis is based on the application of a chlorhexidine gel against the non-application on the healing abutments in patients who have received a submerged titanium implant to check its effect on healing and prevention of bacterial plaque accumulation during a period of 1 month.

Detailed description: Once the implants are integrated, and given the consent, the patients will be operated to connect the healing abutments as they come from the manufacturer (Mozo Grau, Ticare®). Patients will follow the study protocol in 2 arms.

The random distribution is made prior to assignment following the internet program https://www.random.org

Eligibility criteria: Inclusion Criteria:

* Good systemic health status (ASA I or II).
* No current pain.
* No use of painkillers or Anti-inflammatory drugs in the prior weeks.
* Older than 18 years.
* Oral hygiene index of ≤ 2 (Löe and Silness).
* A minimum of 2 mm of adhered gum.
* A minimum of 8 mm of vertical bone.
* A minimum of 7 mm of vestibule-lingual bone.
* Scheduled to receive a unitary implant.
* Willing to participate in this controlled study.

Exclusion Criteria:

* Pregnant or nursing women.
* Use of any type of medication that might affect the perception of pain.
* An history of alcohol or drug abuse.
* A requirement for guided regeneration or sinus lifting procedures.
* Failure to comply with the study protocol.

Primary outcomes:
measure: Degree of inflammation
timeFrame: 1 month after second surgery
Secondary outcomes:
Other outcomes:
Locations:
city: Murcia
country: Spain
facility: Odontologic Universitary Clinic
Study officials:
affiliation: Universidad de Murcia
name: Arturo Sánchez-Pérez, Professor
role: PRINCIPAL_INVESTIGATOR
References: