Clinical trial NCT06286683: Impact of Early Mobilization on SAH Patients Physiological Parameters
Official title: Impact of Early Out-of-bed Mobilization on Physiological Parameters of Patients Admitted to Intensive Care for Subarachnoid Hemorrhage
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Subarachnoid Hemorrhage
Keywords: Early mobilization
Brain perfusion
Transcranial doppler
Near-infrared spectroscopy
Lung Ultrasound
Lead sponsor: Assistance Publique - Hôpitaux de Paris
Sponsor class: OTHER
First posted: 2024-02-29
Enrollment: 100
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients admitted to intensive care for aneurysmal subarachnoid hemorrhage (SAH) and eligible for their first outof-bed mobilization

Brief summary: The aim of the study is to evaluate the physiological response to out-of-bed mobilization in patients admitted to the intensive care unit for subarachnoid hemorrhage. More specifically, the aim is to measure the impact on cerebral perfusion, lung aeration, cardiovascular and respiratory parameters.

Detailed description: In patients with subarachnoid hemorrhage, the mobilization strategy has been little studied. Several studies have already evaluated the consequences of mobilization in bed. Because of the deleterious consequences of prolonged bed rest, and in line with recommendations, practices have evolved towards early out-of-bed mobilization, which has shown benefits. However, the physiological consequences of out-of-bed mobilization have not yet been assessed. The aim of this study is to measure the impact of early out-of-bed mobilization of patients admitted for SAH on neuro-cardio-pulmonary physiological parameters.

Eligibility criteria: Inclusion Criteria:

Age ≥ 18 years

* Aneurysmal SAH
* Severity score World Federation Neurological Surgeons I to IV
* Secured aneurysm
* Eligible for their first early mobilization

Exclusion Criteria:

* Sedated patient
* Disturbed alertness, coma
* Unsecured aneurysm
* Patients under legal protection (guardianship, curatorship, safeguard of justice)

Primary outcomes:
measure: Impact on lung aeration
timeFrame: at T0 before initiation of out-of-bed mobilization, and 15 minutes after moving to the chair.
Secondary outcomes:
measure: Impact on cerebral blood flow
timeFrame: At T0 before initiation of out-of-bed mobilization, immediately after moving to the edge the bed, immediately after moving to the chair.
measure: Impact on cerebral tissue oxygenation
timeFrame: At T0 before initiation of out-of-bed mobilization, immediately after moving to the edge the bed, immediately after moving to the chair.
measure: Impact on heart rate
timeFrame: At T0 before initiation of out-of-bed mobilization, immediately after moving to the edge the bed, immediately after moving to the chair.
measure: Impact on arterial pressure
timeFrame: At T0 before initiation of out-of-bed mobilization, immediately after moving to the edge the bed, immediately after moving to the chair.
measure: Impact on Saturation
timeFrame: At T0 before initiation of out-of-bed mobilization, immediately after moving to the edge the bed, immediately after moving to the chair.
measure: Impact on neurological examination
timeFrame: At T0 before initiation of out-of-bed mobilization, immediately after moving to the edge the bed, immediately after moving to the chair.
measure: Impact on patient comfort
timeFrame: At T0 before initiation of out-of-bed mobilization, immediately after moving to the edge the bed, immediately after moving to the chair.
Other outcomes:
Locations:
city: Paris
country: France
facility: Adéla FOUDHAÏLI
Study officials:
References: