Clinical trial NCT02796911: Comparative Study of Different Bone Grafts in Accelerating Tooth Movement
Official title: Effectiveness of Bovine Derived Xenograft Versus Bioactive Glass With Periodontally Accelerated Osteogenic Orthodontics in Adults
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Orthodontics
Lead sponsor: King Abdulaziz University
Sponsor class: OTHER
First posted: 2016-06-13
Enrollment: 30
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Objective: Periodontally accelerated osteogenic orthodontics(PAOO) will minimize treatment time. The current study will be carried to evaluate the effectiveness of different bone grafts with a modified, less invasive corticotomy technique in the treatment of adult patients with moderate crowding.

Subjects and Methods: Thirty orthodontic patients will be selected. Patients were randomly classified into three groups. Group I will be treated with a modified technique of corticotomy, whereas group II will be treated with the same technique combined with PAOO using bovine derived xenograft, and group III will be treated with the same technique combined with PAOO using with bioactive glass. The total duration of active orthodontic treatment will be estimated. Probing depth, bone density and root length will be also evaluated. The measurements will be recorded.

Detailed description: Objective: Periodontally accelerated osteogenic orthodontics(PAOO) combines periodontal therapy with orthodontic therapy, which will minimize treatment time. The current study will be carried to evaluate the effectiveness of bovine derived xenograft versus bioactive glass with a modified, less invasive corticotomy technique in the treatment of adult patients with moderate crowding.

Subjects and Methods: Thirty orthodontic patients will be selected. Patients were randomly classified into three groups. Group I will be treated with a modified technique of corticotomy on the labial side only, whereas group II will be treated with the same technique combined with PAOO using bovine derived xenograft, and group III will be treated with the same technique combined with PAOO using with bioactive glass. The total duration of active orthodontic treatment will be estimated from the time of starting the active orthodontic treatment, immediately following the corticotomy procedure, to the time of debonding. Probing depth will be evaluated clinically whereas bone density and root length will be evaluated radiographically. The measurements will be recorded at day of surgery (baseline) (T1), post-treatment at time of debonding (T2), and 9 months post-treatment (T3).

Eligibility criteria: Inclusion Criteria:

* A moderate 4-5mm crowding of the lower anterior teeth
* Good oral hygiene
* Healthy systemic condition

Exclusion Criteria:

* previous orthodontic treatment
* Probing depth values exceeding 3 mm
* Radiographic evidence of bone loss
* Regular administration medication that affects bone metabolism such as prolonged use of corticosteroids, or bisphosphonates and NSAIDs.

Primary outcomes:
measure: Speed of tooth movement
timeFrame: Baseline (T1), post-treatment at time of debonding (T2), and 9 months post-treatment (T3).
Secondary outcomes:
measure: Bone density
timeFrame: Baseline (T1), post-treatment at time of debonding (T2), and 9 months post-treatment (T3).
measure: Root length
timeFrame: Baseline (T1), post-treatment at time of debonding (T2), and 9 months post-treatment (T3).
Other outcomes:
Locations:
city: Jeddah
country: Saudi Arabia
facility: King Abdelaziz University. Faculty of dentistry
Study officials:
References:
citation: Bahammam MA. Effectiveness of bovine-derived xenograft versus bioactive glass with periodontally accelerated osteogenic orthodontics in adults: a randomized, controlled clinical trial. BMC Oral Health. 2016 Nov 30;16(1):126. doi: 10.1186/s12903-016-0321-x.