Clinical trial NCT04115683: Dual Task Training in Parkinson's Disease
Official title: Effect of Dual Task Training on Balance, Gait, Cognition and Neurotrophic Factors in Parkinson's Disease
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Parkinson Disease
Lead sponsor: Gazi University
Sponsor class: OTHER
First posted: 2019-10-04
Enrollment: 20
Sex: ALL
Minimum age (years): 40
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The aim of study is to analyze the effects of dual task training on balance, gait, cognition and neurotrophic factors in Parkinson's disease.

Detailed description: 20 patients diagnosed with Parkinson's disease will be randomly assigned to either intervention or control group. And 10 healty subjects will be included to study in order to determine the reference values.The intervention group will be recieved cognitive and motor dual task training consisting of balance and walking activities 3 days a week for 8 weeks. Control group will be recieved same balance and walking activities in single task condition 3 days a week for 8 weeks. In order to evaluate the effects of the training, evaluations will be performed before and after the training period.

Eligibility criteria: Inclusion Criteria:

* at least 40 years of age
* neurologist-diagnosed Parkinson's Disease
* Hoehn \& Yahr (H\&Y) stages 1 to 3
* 24 or more mini mental status examination score.

Exclusion Criteria:

* other neurologic disorder
* cardiovascular, inflammatory,vestibular or musculoskeletal problems that could prevent them to participate in an exercise program
* had deep brain stimulation history
* visual, auditory, orientational problems that could affect study results

Primary outcomes:
measure: Balance-Postural Stability
timeFrame: 8 weeks
measure: Balance- Limits of Stability
timeFrame: 8 weeks
measure: Balance- Modified Sensory Organization Tests
timeFrame: 8 weeks
measure: Gait Speed
timeFrame: 8 weeks
measure: Cadence
timeFrame: 8 weeks
measure: Stride width
timeFrame: 8 weeks
measure: Stride length
timeFrame: 8 weeks
measure: Montreal Cognitive Assessment (MoCA)
timeFrame: 8 weeks
measure: Change in brain derived neurotrophic factor (BDNF) levels of serum
timeFrame: 8 weeks
measure: Change in vascular endothelial growth factor (VEGF) levels of serum
timeFrame: 8 weeks
measure: Change in insulin like growth factor 1 (IGF-1) levels of serum
timeFrame: 8 weeks
Secondary outcomes:
measure: Hoehn and Yahr Scale for level of physical disability in Parkinson's disease.
timeFrame: 8 weeks
measure: Unified Parkinson's Disease Rating Scale (UPDRS)
timeFrame: 8 weeks
measure: Berg Balance Scale (BBS)
timeFrame: 8 weeks
measure: One-legged Stance Test
timeFrame: 8 weeks
measure: Timed Up and Go (TUG) test
timeFrame: 8 weeks
measure: Activities-Specific Balance Confidence (ABC) Scale
timeFrame: 8 weeks
measure: Stroop Test
timeFrame: 8 weeks
measure: Trail Making Test (TMT) Part A and B
timeFrame: 8 weeks
measure: Short-Form 8-Item Parkinson's Disease Questionnaire (PDQ-8)
timeFrame: 8 weeks
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Gazi University, Faculty of Health Sciences
Study officials:
References: