louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT01979575: Trendelenburg Study
Official title: An Observational Study on the Effects of Steep Trendelenburg Position and Pneumoperitoneum on Hemodynamic Changes Observed With Non-invasive Cardiac Monitors
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Comparison of Non-invasive Monitors of Cardiac Function
Keywords: Nexfin
Flotrac
Esophageal
Cardiac output
Lead sponsor: University of California, Davis
Sponsor class: OTHER
First posted: 2013-11-08
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients scheduled for elective surgery.

Brief summary: 1) Observe the hemodynamic and cardiovascular changes associated with the change from the supine to the steep Trendelenburg position, 2) Observe the hemodynamic and cardiovascular changes during intra-abdominal insufflation used during laparoscopic surgical procedures.

Detailed description: This is a single site, prospective, non-blinded, non-randomized, non-interventional study designed to evaluate the hemodynamic and cardiovascular effects of the steep Trendelenburg position on non-invasive or minimally invasive monitors used in the operating room during surgical procedures requiring this patient position.

SPECIFIC AIMS: 1) Observe the hemodynamic and cardiovascular changes associated with the change from the supine to the steep Trendelenburg position. 2) Observe the hemodynamic and cardiovascular changes during intra-abdominal insufflation used during laparoscopic surgical procedures.

HYPOTHESIS: Hemodynamic and cardiovascular changes during alterations in position from supine to steep Trendelenburg and intra-abdominal insufflation measured by non-invasive and minimally invasive monitors will correlate with transthoracic echocardiographic measurements.

Eligibility criteria: Inclusion Criteria:

* Scheduled for elective surgery requiring steep trendelenburg positioning.

Exclusion Criteria:

* BMI \>30. \<18 years. Pregnancy. Prisoners.

Primary outcomes:
measure: An observational study on the effects of steep Trendelenburg position and pneumoperitoneum on hemodynamic changes observed with non-invasive cardiac monitors
timeFrame: One year.
Secondary outcomes:
Other outcomes:
Locations:
city: Sacramento
country: United States
facility: UC Davis Health System
state: California
Study officials:
References:
Clinical trial NCT00214175: Determination of Fraction Size Equivalent Dose (FED) Levels for Intracranial Conformal Avoidance Radiotherapy
Official title: Determination of Fraction Size Equivalent Dose (FED) Levels for Intracranial Conformal Avoidance Radiotherapy
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Glioma
Brain Neoplasms
Keywords: low grade gliomas and benign CNS lesions
Lead sponsor: University of Wisconsin, Madison
Sponsor class: OTHER
Collaborators: name: National Cancer Institute (NCI)
First posted: 2005-09-21
Enrollment: 44
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Study patients will come from the population that is referred to radiotherapy for treatment of their low grade glioma or benign brain lesion and will undergo fractionated radiotherapy. The volunteers will be a spouse or sibling of a patient

Brief summary: The primary objective is to evaluate and quantify the reproducibility of functional magnetic resonance imaging (fMRI) maps of the eloquent brain areas corresponding to specific neurological functions based on activation maps obtained with different thresholds in patients with benign and biopsy proven low-grade brain neoplasms. Another objective is to access the impairment in neurological function in image guided intracranial radiotherapy using neurocognitive assessment tools and to derive dose response curves relating the impairment in a particular neurological function to the FED received by the area of eloquent brain corresponding to it.


Eligibility criteria: Inclusion Criteria:

* Indication for brain radiotherapy.
* Ability to undergo MRI scans and time to participate in neurocognitive testing.

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Madison
country: United States
facility: University of Wisconsin Hospital and Clinics
state: Wisconsin
Study officials:
affiliation: University of Wisconsin, Madison
name: Wolfgang Tome, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00383175: Reading Fluency and Accommodative Lag
Official title: Reading Fluency and Accommodative Lag
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Ocular Accommodation
Keywords: Ocular Accommodation
Reading
Lead sponsor: University of Alabama at Birmingham
Sponsor class: OTHER
Collaborators: name: National Eye Institute (NEI)
First posted: 2006-10-02
Enrollment: 72
Sex: ALL
Minimum age (years): 5
Maximum age (years): 9
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to determine whether special reading glasses improve children's ability to learn to read.

Detailed description: Many children are believed to under accommodate (have a lag of accommodation) when looking at near targets. If this occurs, the retinal image is out of focus. Children who have a lag of accommodation may have difficulty in focusing their eyes at near for long periods of time. This difficulty could reduce their ability to read fluently. Children with above average lags of accommodation will be randomly assigned to a group which receives special reading glasses or a group which does not. The groups will be assessed using a standard test for reading fluency.

Eligibility criteria: Inclusion Criteria:

* Children in grades 1, 2 and 3 who consent and assent to participate

Exclusion Criteria:

* Children in the special education program
* Children who are unwilling to have their eyes dilated or be tested
* Children who are unwilling to wear the glasses

Primary outcomes:
measure: DIBELS test scores .
timeFrame: 1 -2 years
Secondary outcomes:
Other outcomes:
Locations:
city: Eutaw
country: United States
facility: Eutaw Primary School
state: Alabama
Study officials:
affiliation: University of Alabama at Birmingham
name: Robert Kleinstein, OD,MPH,PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01042275: Patient-reported Outcome After Sling Insertion Using the Incontinence Outcome Questionnaire (IOQ)
Official title: Patient-reported Mid- and Long-term Outcome After Insertion of Retropubic and Transobturator Tapes Using the Incontinence Outcome Questionnaire (IOQ)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Stress Urinary Incontinence
Keywords: stress urinary incontinence
retropubic sling
transobturator sling
tension-free vaginal tape
transobturator tape
TVT
TVT-O
TOT
REMEEX
IVS
Lead sponsor: University of Zurich
Sponsor class: OTHER
First posted: 2010-01-05
Enrollment: 628
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: patients who were treated at 2 Swiss public teaching hospitals

Brief summary: Midurethral tapes are by now standard procedure in the surgical treatment of women with stress urinary incontinence. While the retropubic TVT is well documented with long-term results up to 11 years and continence rates of 90 %, the published data for the transoburator tapes (TO) cover follow-up of 3 years only. So far, all tapes establish continence effectively. Recently, the detailed 27-item Incontinence Outcome Questionnaire (IOQ) was constructed to assess patient-reported outcome and quality of life after insertion of a midurethral tape and validated for the German language. The aim of this study was to evaluate patient-reported mid- and long-term outcome after insertion of tension-free vaginal tape (TVT), transobturator sling, outside-in (TOT) and tension-free transobturator tape, inside-out (TVT-O).


Eligibility criteria: Inclusion Criteria:

* incontinence sling
* time frame 1/1999 - 12/2007

Primary outcomes:
measure: patient's satisfaction
timeFrame: 3/2009
Secondary outcomes:
measure: re-admission
timeFrame: 3/2009
Other outcomes:
Locations:
city: Zurich
country: Switzerland
facility: University of Hospital, Clinic for Gynecology
Study officials:
affiliation: Clinic for Gynecology, University Hospital of Zurich
name: Cornelia Betschart, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02040675: Use of NAVA-catheter Positioning Screen to Identify Different Cardiac Arrhythmias
Official title: Use of NAVA-catheter Positioning Screen to Identify Different Cardiac Arrhythmias
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cardiac Arrhythmia
Lead sponsor: ProMedica Health System
Sponsor class: OTHER
First posted: 2014-01-20
Enrollment: 5
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: The population will be a convenience sample of adults with various arrhythmias who are scheduled to undergo an electrophysiology study and-or ablation (EPSA) under general anesthesia (GETA) at The Toledo Hospital.

Brief summary: The purpose of this study is to validate a novel method of diagnosing arrhythmias using the NAVA catheter-positioning screen in patients who have a NAVA catheter in place.

Detailed description: The population will be a convenience sample of adults with various arrhythmias who are scheduled to undergo an electrophysiology study and-or ablation (EPSA) under general anesthesia (GETA) at The Toledo Hospital.

After the patient has been successfully intubated at the beginning of the procedure, a trained nurse, using standard technique for placement of a oro/nasogastric tube, will place an appropriately sized NAVA catheter in the patient. The lumen of the NAVA tube can be used as a conventional oro/nasogastric tube and the electrodes will be connected to the Servo-I ventilator. Although the Servo-I is a ventilator, it will be used only as a monitor for this study. The position of the nasogastric tube will then be refined using the catheter positioning screen as needed.

During the course of the EPSA various arrhythmias may become evident. When these are noted, screen shots will be saved on the Servo-i monitor. Surface and electrogram recordings will be saved at the same time. The NAVA catheter will be disconnected from the Servo-I monitor during the ablation part of the procedure to prevent inadvertent damage to the monitor.

Eligibility criteria: Inclusion Criteria:

* Cardiac arrhythmia

Exclusion Criteria:

* Pregnancy

Primary outcomes:
measure: Types of cardiac arrhythmia
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Toledo
country: United States
facility: Promedica Toledo Hospital
state: Ohio
Study officials:
affiliation: Promedica Toledo CHildren's Hospital
name: Howard Stein, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06789575: Comparison of Bupivacaine Wound Infiltration Versus Wound Instillation to Minimize Postoperative Pain After Thyroid Surgery
Official title: Comparison of Bupivacaine Wound Infiltration Versus Wound Instillation to Minimize Postoperative Pain After Thyroid Surgery
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: PHASE3
Conditions: Thyroid Surgery
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2025-01-23
Enrollment: 102
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Pain management following thyroidectomies, which can cause mild to moderate postoperative pain, particularly in the first 24 hours following surgery, has received little attention . The incision of the wound, neck hyperextension, retraction of the wound margins during surgery, and dissection are the main reasons of post-thyroidectomy discomfort . After thyroid surgery, pain management improves patients' quality of life and facilitates a speedy return to regular daily activities.

the aim of the study to evaluate the effects of bupivacaine instillation after thyroidectomy against infiltration into the surgical field in order to reduce postoperative discomfort following thyroid surgery.

Detailed description: Pain management following thyroidectomies, which can cause mild to moderate postoperative pain, particularly in the first 24 hours following surgery, has received little attention . The incision of the wound, neck hyperextension, retraction of the wound margins during surgery, and dissection are the main reasons of post-thyroidectomy discomfort . After thyroid surgery, pain management improves patients' quality of life and facilitates a speedy return to regular daily activities.

Eligibility criteria: Inclusion Criteria:

* Normal thyroid function patients of both genders scheduled for thyroid surgery will included in this study
* If they are over the age of 18
* If they had an ASA score (American Society of Anesthesiology) I, II.
* A Score of Mallampati I , II.

Exclusion Criteria:

* Patient refused to participate in the study.
* Patients will be excluded if they have any analgesic medication or corticosteroid drug prior surgery or
* A known or suspected allergy to local anesthetics,
* if the duration of surgery is greater than 5 h and if a major complication of surgery or anesthesia (major bleeding, allergy to anesthetic products).
* Patients who have lateral neck dissection associated with Thyroid surgery are excluded.

Primary outcomes:
measure: Total analgesic consumption
timeFrame: 24 hours
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT06946875: Factors Associated With Pain Threshold in Young Adults With Chronic Neck Pain
Official title: The Effect of Pain Intensity, Neck Disability, Anxiety, and Quality of Life on Pain Threshold in Young Adults With Chronic Neck Pain
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Neck Pain Chronic
Lead sponsor: KTO Karatay University
Sponsor class: OTHER
First posted: 2025-04-27
Enrollment: 80
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: PROBABILITY_SAMPLE
Study population: Young Adults with Chronic Neck Pain

Brief summary: The aim of this study was to determine which factors affect treatment expectations in individuals with chronic neck pain.


Eligibility criteria: Inclusion Criteria:

* To be examined by specialised physicians and diagnosed with chronic neck pain, to be physically and mentally fit to participate in the study.

Exclusion Criteria:

* The presence of instability in the neck joints, trauma within the last year, severe osteoporosis, previous neck surgery, physical therapy within the last 6 months, neurological findings or radiculopathy were determined.

Primary outcomes:
measure: Pain Threshold
timeFrame: Baseline
Secondary outcomes:
measure: Visual Analogue Scale
timeFrame: Baseline
measure: Neck Disability Index
timeFrame: Baseline
measure: Nottingham Health Profile
timeFrame: Baseline
measure: Beck Anxiety Scale
timeFrame: Baseline
Other outcomes:
Locations:
Study officials:
References:
Clinical trial NCT04926675: Development of a Money Advice Intervention Within IAPT
Official title: Development of a Money Advice Intervention Within IAPT: Service User Case-studies
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Mental Health Issue
Anxiety
Depression
Lead sponsor: King's College London
Sponsor class: OTHER
First posted: 2021-06-15
Enrollment: 35
Sex: ALL
Minimum age (years): 18
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Intervention model description: Interventional study of adding money advice to psychological treatment compared to usual treatment from routine data collection
Primary purpose: TREATMENT

Brief summary: This study is the second study of a larger project and will begin the process of testing and the development of an integrated intervention on a series of case studies. The combined intervention provides psychological therapy and debt advice in tandem. The treatment pathway is based on interviews and focus groups with service users and staff and the themes that emerged. It will be trialled in the NHS' Improving Access to Psychological Therapies (IAPT) service. Participants routinely accessing this service who have debt issues affecting their mental health will be asked if they'd like to also take up support for their money worries, which will be provided by Citizen's Advice (CA). Researchers will take exit interviews with both service users and staff at the end of the treatment to develop the protocol further. Researchers will also assess measures of mental health and wellbeing that are routinely taken by IAPT to review the intervention.


Eligibility criteria: Inclusion Criteria:

* IAPT clients referred for 'high-intensity' one-to-one treatment in the South London and Maudsley NHS Trust (SLaM)
* Have mental health problems and experience of money problems that are effecting these
* Can access technology

Exclusion Criteria:

* Inability to give informed consent due to mental incapacity (as assessed by IAPT therapists)
* Participants whose care team specify concerns regarding taking part in the study.

Primary outcomes:
measure: Reliable recovery - anxiety
timeFrame: 6-12 weeks
measure: Reliable recovery - depression
timeFrame: 6-12 weeks
measure: Reliable recovery - adjustment
timeFrame: 6 - 12 weeks
Secondary outcomes:
measure: Financial Outcomes and service satisfaction
timeFrame: 6-12 weeks
Other outcomes:
Locations:
city: London
country: United Kingdom
facility: King's College London
Study officials:
affiliation: King's College London
name: Til Wykes, Prof. Dame.
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT04204759: Transcranial Direct Current Stimulation and Antisocial Behavior
Official title: The Effect of Transcranial Direct Current Stimulation of the Prefrontal Cortex on Antisocial Behavior
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Aggression
Keywords: transcranial direct curren stimulation
antisocial behavior
Lead sponsor: Nanyang Technological University
Sponsor class: OTHER
First posted: 2019-12-19
Enrollment: 101
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: The main objective of this study is to investigate the causal relationship between prefrontal cortex activity and antisocial behavior, as well as risk factors for antisocial behavior. Specifically, this study tests the hypothesis that upregulating activity in the prefrontal cortex through a non-invasive form of brain stimulation, transcranial direct current stimulation (tDCS) will reduce antisocial and aggressive behavior. The effects of 3 days of anodal stimulation over the prefrontal cortex are assessed.


Eligibility criteria: Inclusion Criteria:

* Above 18 (with parental consent) or above 21 (without parental consent)
* Able to understand the nature of the study and give informed consent

Exclusion Criteria:

* History of or active neurologic, cardiovascular, or psychiatric disease including anxiety disorders (e.g., PTSD, panic attacks, obsessive-compulsive disorder) and mood disorders (e.g., depression)
* Currently consuming anti-convulsant, anti-psychotic, or sedative/hypnotic medications
* Currently consuming anti-depressants
* History of seizures
* Metallic implants on scalp
* Participated in any other non-invasive brain stimulation study in the same day
* Ever had an adverse reaction to tDCS

Primary outcomes:
measure: Points in the Point Subtraction Aggression Paradigm after stimulation
timeFrame: Within 1 hour after the third consecutive active tDCS or sham session
measure: Antisocial behavior inclinations after stimulation
timeFrame: Within 1 hour after the third consecutive active tDCS or sham session
measure: Moral judgment ratings after stimulation
timeFrame: Within 1 hour after the third consecutive active tDCS or sham session
measure: Delay discounting rates after stimulation
timeFrame: Within 1 hour after the third consecutive active tDCS or sham session
measure: Helping behavior after stimulation
timeFrame: Within 1 hour after the third consecutive active tDCS or sham session
measure: Antisocial behavior after stimulation
timeFrame: Within 1 hour after the third consecutive active tDCS or sham session
Secondary outcomes:
measure: Number of participants with adverse events
timeFrame: Within 1 hour after each of the 20-minute active tDCS or sham sessions
Other outcomes:
Locations:
city: Singapore
country: Singapore
facility: Nanyang Technological University
Study officials:
affiliation: Nanyang Technological University
name: Olivia Choy, PhD
role: PRINCIPAL_INVESTIGATOR
References: