Clinical trial NCT02550405: The Behavioral and Brain Mechanism of IGD
Official title: The Behavioral and Brain Mechanism of Internet Gaming Disorder
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Internet Gaming Disorder
Lead sponsor: Beijing Normal University
Sponsor class: OTHER
First posted: 2015-09-15
Enrollment: 204
Sex: MALE
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: NON_RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: This project aims to investigate whether anodal tDCS of dlPFC enhances cognitive regulation over craving an emotions.


Eligibility criteria: Inclusion Criteria:

* Inclusion criteria for IGDs were:

  1. a score of 67 or higher on the CIAS;
  2. engagement in Internet gaming for over 14 hours per week for a minimum of one year; and
  3. reporting of Internet gaming as their primary online activity;
* Inclusion criteria for HCs were:

  1. a score \< 60 on the CIAS;
  2. never having spent more than 2 hours per week engaged in Internet gaming

Exclusion Criteria:

* for all participants:

  1. current or history of use of illegal substances and gambling;
  2. current or history of psychiatric or neurological illness; and
  3. current use of psychotropic medications

Primary outcomes:
measure: Brain resting state functional connectivity as measured by fMRI
timeFrame: Detecting changes between two different time points (baseline and 6 weeks)
measure: Brain activation during a cue-induced craving task as measured by fMRI
timeFrame: Detecting changes between two different time points (baseline and 6 weeks)
Secondary outcomes:
measure: Brain activation during the Cups task as measured by fMRI
timeFrame: Detecting changes between two different time points (baseline and 6 weeks)
measure: Brain activation during the mixed gambling task tasks as measured by fMRI
timeFrame: Detecting changes between two different time points (baseline and 6 weeks)
measure: Brain structure as measured by structural MRI
timeFrame: Detecting changes between two different time points (baseline and 6 weeks)
measure: IGD severity measured by Chen Internet addiction scale
timeFrame: Detecting changes between two different time points (baseline and 6 weeks)
measure: Craving as measured by brief questionnaire of Internet (gaming) craving
timeFrame: Detecting changes between two different time points (baseline and 6 weeks)
measure: Impulsivity as measured by Barratt impulsive scale (BIS-II)
timeFrame: Detecting changes between two different time points (baseline and 6 weeks)
measure: weekly online (gaming) time
timeFrame: Detecting changes between two different time points (baseline and 6 weeks)
Other outcomes:
Locations:
city: Beijing
country: China
facility: State Key Laboratory of Cognitive Neuroscience and Learning
state: Beijing
Study officials:
affiliation: Institute of Developmental Psychology, Beijing Normal University
name: XiaoYi Fang, PhD
role: STUDY_CHAIR
affiliation: State Key Laboratory of Cognitive Neuroscience and Learning
name: JinTao Zhang, PhD
role: STUDY_CHAIR
affiliation: Institute of Developmental Psychology, Beijing Normal University
name: CuiCui Xia, MEd
role: PRINCIPAL_INVESTIGATOR
affiliation: Faculty of Education Beijing Normal University
name: LinYuan Deng, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Institute of Developmental Psychology, Beijing Normal University
name: Lu Liu, BS
role: PRINCIPAL_INVESTIGATOR
affiliation: State Key Laboratory of Cognitive Neuroscience and Learning
name: Ben Liu, BSM
role: PRINCIPAL_INVESTIGATOR
affiliation: State Key Laboratory of Cognitive Neuroscience and Learning
name: ShanShan Ma, BS
role: PRINCIPAL_INVESTIGATOR
affiliation: State Key Laboratory of Cognitive Neuroscience and Learning
name: YuanWei Yao, BS
role: PRINCIPAL_INVESTIGATOR
affiliation: School of Psychology Central China Normal University
name: Qinxue Liu, PhD
role: PRINCIPAL_INVESTIGATOR
affiliation: Institute of Developmental Psychology, Beijing Normal University
name: Nan Zhou, MEd
role: PRINCIPAL_INVESTIGATOR
affiliation: Institute of Developmental Psychology, Beijing Normal University
name: ShuMeng Hou, MEd
role: PRINCIPAL_INVESTIGATOR
References:
citation: Dong G, Potenza MN. A cognitive-behavioral model of Internet gaming disorder: theoretical underpinnings and clinical implications. J Psychiatr Res. 2014 Nov;58:7-11. doi: 10.1016/j.jpsychires.2014.07.005. Epub 2014 Jul 17.
citation: Liu L, Yao YW, Li CR, Zhang JT, Xia CC, Lan J, Ma SS, Zhou N, Fang XY. The Comorbidity Between Internet Gaming Disorder and Depression: Interrelationship and Neural Mechanisms. Front Psychiatry. 2018 Apr 23;9:154. doi: 10.3389/fpsyt.2018.00154. eCollection 2018.
citation: Deng LY, Liu L, Xia CC, Lan J, Zhang JT, Fang XY. Craving Behavior Intervention in Ameliorating College Students' Internet Game Disorder: A Longitudinal Study. Front Psychol. 2017 Apr 10;8:526. doi: 10.3389/fpsyg.2017.00526. eCollection 2017.