Clinical trial NCT04442087: Study of Seroprevalence of Anti-SARS-CoV2 Among Children of Hospital Workers in AP-HP
Official title: Seroprevalence of Anti-SARS-CoV2 Among Children According to Parents' SARS-CoV2 Serological Status. Study in a Hospital Population Assistance Publique-Hôpitaux Paris
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: SARS-CoV2
Keywords: SARS-CoV2
COVID-19
Serology
Hospital workers
Children
Lead sponsor: Assistance Publique - Hôpitaux de Paris
Sponsor class: OTHER
First posted: 2020-06-22
Enrollment: 563
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: BASIC_SCIENCE

Brief summary: The purpose of this study is to define seroprevalence of anti-SARS-CoV2 among children of Hospital Workers in APHP, particularly exposed population, according to parents' SARS-CoV2 serological status.


Eligibility criteria: Inclusion Criteria:

Hospital workers :

1. Individuals aged over 18, having a professional activity at the APHP (employees, interns, volunteers)
2. Affiliated to a social security regimen
3. Have at least one child under the age of 18 living in the same house.
4. have signed consent

Child (ren), spouse and other member (s) residing at household:

Child (ren), spouse and any other member residing in the household of a professional of the Paris Center Hospitals meeting the inclusion criteria above.

Exclusion Criteria:

Refuse to participate in research

Primary outcomes:
measure: Seroprevalence of antibodies anti- SARS Cov2 in blood sample of children of Hospital workers
timeFrame: at inclusion
measure: Seroprevalence of antibodies anti- SARS Cov2 in saliva sample of children of Hospital workers
timeFrame: at inclusion
Secondary outcomes:
measure: Number of Asymptomatic Children with a positive seroloy
timeFrame: At inclusion
measure: Number of severely symptomatic Children with a positive serology
timeFrame: At inclusion
measure: Prevalence of different clinical symptoms in children with a positive serology
timeFrame: At inclusion
measure: Serological result of each member of the family
timeFrame: At inclusion
measure: Number of spouses of hospital workers with a positive serology
timeFrame: At inclusion
measure: Number of Asymptomatic spouses of hospital workers with a positive serology
timeFrame: At inclusion
measure: Number of severely symptomatic spouses of hospital workers with a positive serology
timeFrame: At inclusion
measure: Comparison of Serological result obtained in blood and saliva samples
timeFrame: At inclusion
measure: Risk factors based on a questionnaire for children and adults
timeFrame: At inclusion
Other outcomes:
Locations:
city: Paris
country: France
facility: Centre d'investigation clinique (CIC) Necker Cochin in Necker Children's Hospital
Study officials:
affiliation: Assistance Publique - Hôpitaux de Paris
name: Solen KERNEIS, MD
role: STUDY_DIRECTOR
affiliation: Assistance Publique - Hôpitaux de Paris
name: Flore ROZENBERG, MD, PhD
role: STUDY_DIRECTOR
affiliation: Assistance Publique - Hôpitaux de Paris
name: Jean-Marc TRELUYER, MD, PhD
role: PRINCIPAL_INVESTIGATOR
References: