Clinical trial NCT02941861: Factors Influencing the 3-Year Recurrence of Liver Carcinoma After Surgery
Official title: Factors Influencing the 3-Year Recurrence of Liver Carcinoma After Surgery
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Liver Cancer
Recurrence
Keywords: Hepatocellular carcinoma
Cholangiocarcinoma
Recurrence
Lead sponsor: Chulabhorn Hospital
Sponsor class: OTHER
First posted: 2016-10-21
Enrollment: 67
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: There were 33 and 34 patients underwent liver resection for Hepatocellular carcinoma and Cholangiocarcinoma respectively between February 2010 to December 2013. All patients were staged according to the tumor-node metastasis (TNM) system and appraised by the hospital tumor board conference. After surgery, an attending physician followed up patients by tumor marker and imaging as standard treatment as well as diagnosed its recurrence. In addition, all recurrence cases had standard treatments till the end of life. The survival was classified as the dates between the operation and the death.

Brief summary: Objective:

1. To study the factors that influence the 3- year recurrence of liver carcinoma after surgery
2. To study the related factors affecting recurrence of liver carcinoma after surgery

Detailed description: Liver carcinoma including 80% Hepatocellular carcinoma (HCC) and 20% Cholangiocarcinoma (CCA) becomes the leading causes of death in East and South-East Asia. Though hepatectomy is the treatment of choice for early stage cancer, the recurrence has been reported as 30%, 62% and 79% in 1st, 3rd and 5th year respectively. Chulabhorn hospital, a cancer institute established in 2011, has been performing a 3-years retrospective study on the influencing factors and its correlation to liver carcinoma after surgery.

Eligibility criteria: Inclusion Criteria:

* All patients underwent liver resection for Hepatiocellular carcinoma and Cholangiocarcinoma respectively including having pathology results between February 2010 to December 2013. Data was received from Cholabhron Hospital's patient database.

Exclusion Criteria:

* All patients having no pathology results were not included.
* All patients having no show for follow up recording were excluded.

Primary outcomes:
measure: Recurrence rate of Liver Carcinoma after surgery
timeFrame: 3 years
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
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