Clinical trial NCT02499536: Relationship Between Atelectasis on Ultrasound and PaO2/FiO2
Official title: Relationship Between Intraoperative Atelectasis Findings on Transthoracic Lung Ultrasound and PaO2/FiO2
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Atelectasis, Postoperative
Keywords: Atelectasis
Postoperative
Lung ultrasound
Lead sponsor: Severance Hospital
Sponsor class: OTHER
First posted: 2015-07-16
Enrollment: 26
Sex: ALL
Minimum age (years): 20
Maximum age (years): 65
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: The aim of this study is to find out relationship between PaO2/FiO2 and atelectasis finding on intraoperative lung ultrasound.

Detailed description: Patients aged 20\~65 with ASA class (American Society of Anesthesiologists physical status classification) 1 or 2 who are scheduled to undergo general anesthesia by using endotracheal intubation and arterial line cannulation will participate in this study. The patients with abnormal chest x-ray finding, pregnancy, arrhythmia, ischemic heart disease will be excluded from this study as well as the patients who are scheduled to undergo lung or heart surgery.

After 5 minutes preoxygenation, patients will be monitored with pulse oxymetry, noninvasive blood pressure. General anesthesia will be proceeded with typical method and endotracheal intubation and arterial cannulation will be proceeded. After ventilator adjustment (tidal volume as 8 times of the patient's ideal body weight), airway pressures(peak and plateau) will be recorded. Subsequently, arterial blood sampling will be proceeded while examination of the atelectasis findings on lung ultrasound before surgery. Lung ultrasound examination will be proceeded on 6 sections of patient's basal segments of the lung, including anterior, lateral, posterior segment. Juxtapleural consolidation, loss of A lines, presence of B lines, air bronchogram, loss of sliding sign and presence of pulse sign on lung ultrasound finding will be investigated and recorded.

Same ultrasound examination and arterial blood sampling will be followed after surgery ends.

The results of PaO2/FiO2 on arterial blood samplings will be compared with findings on lung ultrasound before and after surgery.

Eligibility criteria: Inclusion Criteria:

* Patients aged 20\~65
* with ASA class 1 or 2
* who are scheduled to undergo general anesthesia by using endotracheal intubation and arterial line cannulation

Exclusion Criteria:

* The patients with abnormal chest x-ray finding,
* pregnancy,
* arrhythmia,
* ischemic heart disease

Primary outcomes:
measure: Intraoperative lung ultrasound for atelectasis
timeFrame: Baseline (Before surgery begins) and Postoperative (Just after the surgery ends)
measure: Change in PaO2/FiO2
timeFrame: Baseline (Before surgery begins) and Postoperative (Just after the surgery ends)
Secondary outcomes:
measure: Airway pressure change
timeFrame: Baseline (Before surgery begins) and Postoperative (Just after the surgery ends)
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Gangnam Severance Hospital
state: Gangnam-gu
Study officials:
affiliation: Department of anesthesiology and pain medicine, Gangnam Severance hospital
name: Ji young Kim, MD, PhD
role: STUDY_DIRECTOR
References:
citation: Lichtenstein D, Meziere G, Seitz J. The dynamic air bronchogram. A lung ultrasound sign of alveolar consolidation ruling out atelectasis. Chest. 2009 Jun;135(6):1421-1425. doi: 10.1378/chest.08-2281. Epub 2009 Feb 18.