louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT02697097: Hip Muscle Strength in FAI Versus Normal Controls
Official title: Muscle Strength in Femoroacetabular Impingement: A Comparative Study of Patients With FAI Versus Normal Controls
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Femoro-acetabular Impingement
Keywords: Hip Muscle Strength
FAI
Lead sponsor: Cambridge University Hospitals NHS Foundation Trust
Sponsor class: OTHER
First posted: 2016-03-03
Enrollment: 20
Sex: ALL
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Control Arm Group - Medical Students who fit the inclusion criteria and are between ages of 18-30.

FAI Comparison Group - Participants will be recruited from Young Adult Hip Clinic, meeting the defined inclusion criteria and also being between the ages of 18-30.

Brief summary: Hip Muscle Strength in femoro-acetabular impingement participants versus normal controls.

To investigate the hip muscle strength in a normal control group and compare this to patients who have a diagnosis of femoro-acetabular impingement (diagnosed clinically and with confirmed radiological features).


Eligibility criteria: Inclusion Criteria:

* Males and Females.
* Aged 18-30.
* Control group - Normal range of movement and no evidence of femoro-acetabular impingement on clinical examination (negative impingement test, no symptoms).
* Participants with femoro-acetabular impingement as diagnosed clinically and on radiological imaging for the comparison group (MRI).

Exclusion Criteria:

* Patients under the age of 18.
* Patients over the age of 30.
* Control group - evidence of underlying pathology affecting the hip, abnormal range of motion, evidence of femoro-acetabular impingement on clinical examination.
* Previous surgery of the hip joints.
* Medical history of arthritis (including rheumatoid and reactive).
* Family history of femoro-acetabular impingement (control arm participants).
* Patients who are currently experiencing or have experienced hip pain in the previous 1 year (control arm).
* Other conditions (e.g. neurological, muscular dystrophy etc) which may affect hip muscle strength.

Primary outcomes:
measure: Muscle Strength on Dynamometer
timeFrame: 3 months
Secondary outcomes:
measure: Kinematics of the Hip - Range of Movement
timeFrame: 3 months
Other outcomes:
Locations:
city: Cambridge
country: United Kingdom
facility: Addenbrooke's Hospital
state: Cambridgeshire
Study officials:
affiliation: Consultant Trauma and Orthopaedic Surgeon - Principal Investigator
name: Vikas Khanduja, MA, FRCS (Orth)
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00544297: A Study to Examine the Safety and Toleration of PEP005 Topical Gel in Patients With Actinic Keratoses on the Top of the Hand
Official title: A Multi-center, Open-label Study to Examine the Safety and Toleration of 0.05% PEP005 Topical Gel in Patients With Actinic Keratoses on the Dorsum of the Hand
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE2
Conditions: Actinic Keratosis
Keywords: Actinic Keratosis
Topical
Dermatology
Hand
Lead sponsor: Peplin
Sponsor class: INDUSTRY
Collaborators: name: Omnicare Clinical Research
First posted: 2007-10-16
Enrollment: 12
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to examine the safety and toleration of PEP005 Topical Gel, administered on an actinic keratosis (AK) treatment area on the top of a hand.

Detailed description: Actinic keratoses (AK) is a common skin condition characterized by rough, scaly patches or sores on the top layer of the skin which if left untreated can progress to skin cancer. Current treatments can cause scarring and hypopigmentation, be inconvenient, or require long treatment duration. Non-invasive alternative therapy for treatment of AK lesions is thus being researched.

Eligibility criteria: Inclusion Criteria:

* Male patients at least 18 years of age.
* Post-menopausal female patients
* 4 to 8 clinically typical, visible and discrete AK lesions within an area on the dorsum of one hand.
* Written informed consent has been obtained.
* Agreement from the patient to allow photographs of the selected AK treatment area to be taken and used as part of the study data package.

Primary outcomes:
measure: Incidence of Adverse Events (AEs) and Serious Adverse Events (SAEs); and Local Skin Responses (LSR)
timeFrame: 57 days
Secondary outcomes:
measure: The complete clearance rate of AK lesions; partial clearance rate of AK lesions and baseline clearance rate of AK lesions.
timeFrame: 57 days
Other outcomes:
Locations:
city: San Diego
country: United States
facility: Skin Surgery Medical Group Inc
state: California
city: Snellville
country: United States
facility: Gwinnett Clinical Research Centre
state: Georgia
city: San Antonio
country: United States
facility: Dermatology Clinical Research Centre of San Antonio
state: Texas
city: Tyler
country: United States
facility: Dermatology Associates of Tyler
state: Texas
Study officials:
affiliation: Chief Medical Officer and VP Medical Affairs
name: Arthur P Bertolino, MD
role: STUDY_DIRECTOR
References:
Clinical trial NCT01528397: Reconstruction of Proper Digital Nerve Defects in the Thumb Using a Pedicled Nerve Graft
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Nerve Injury
Keywords: defect
dorsal branch of the proper digital nerve
proper digital nerve
second dorsal metacarpal artery
pedicled nerve graft.
Lead sponsor: The Second Hospital of Tangshan
Sponsor class: OTHER
Collaborators: name: Chinese PLA General Hospital
First posted: 2012-02-08
Enrollment: 14
Sex: ALL
Minimum age (years): 15
Maximum age (years): 60
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: A proper digital nerve (PDN) defect in the thumb can produce partial or complete sensory loss which can result in functional disability. This article reports the treatment of the thumb PDN defect using a pedicled nerve graft harvested from the dorsal branch of the PDN. Fourteen patients with the thumb PDN defect underwent a new surgical procedure in which the pedicled nerve graft was used to bridge nerve defect. For comparison, the investigators also collected a consecutive series of 21 patients with thumb PDN defects treated using a nonvascularized sural nerve graft. This study was designed to evaluate the efficacy of pedicled nerve grafting for PDN defects in the thumb.

Detailed description: At final follow-up, the investigators measured the sensibility of the thumb pulps and the donor sites using the Semmes-Weinstein monofilament test and static 2-point discrimination (2PD) test. The test points were at the centers of the radial and ulnar portions of the thumb pulp and the donor sites separately. Each area was tested 3 times with a Dellon-Mackinnon discriminator. Two out of 3 correct answers were considered proof of perception before proceeding to another lower value.

Eligibility criteria: Inclusion Criteria:

1. thumb PDN defects between the middle of the distal phalanx and the metacarpophalangeal joint;
2. PDN defects of single or both sides;
3. PDN defects 1-4 cm in length.

Exclusion Criteria:

1. injury to the course of the pedicle or the donor sites;
2. PDN defects less than 1 cm or longer than 4 cm;
3. no Doppler sound at the location of the second dorsal metacarpal artery (SDMA).

Primary outcomes:
measure: static 2-point discrimination (2PD) test
timeFrame: 22 months
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Chen C, Tang P, Zhang X. Reconstruction of proper digital nerve defects in the thumb using a pedicle nerve graft. Plast Reconstr Surg. 2012 Nov;130(5):1089-1097. doi: 10.1097/PRS.0b013e318267d56b.
Clinical trial NCT03033797: Augmentative and Alternative Communication in Games With Virtual Reality in Intellectual Disabilities
Official title: Augmentative and Alternative Communication in Games With Virtual Reality in Intellectual Disabilities
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Intellectual Disability
Keywords: assitive technology
virtual reality games
intellectual disability
augmentative and alternative communication
Lead sponsor: Faculdade de Medicina do ABC
Sponsor class: OTHER
First posted: 2017-01-27
Enrollment: 165
Sex: ALL
Minimum age (years): 7
Maximum age (years): 14
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: PREVENTION

Brief summary: Background: Games using motion capture from webcam have become increasingly popular. A population that lacks much stimulus in the teaching-learning process has under-explored the benefits of this kind of games: The Intellectually Disabled. The aim of this study is to analyse the effectiveness of games with virtual reality in the total reaction time. Method: A convenience sample of 165 Intellectually Disabled participants will have their performance measured using a virtual reality game. The intervention is to play two different games twice, in two sessions with an interval of, at least, seven days between the sessions. Participants will be randomized between two raters, both master students.


Eligibility criteria: Inclusion Criteria:

* All the children that uses to go the institution where the data collection will be realised (APAE).

Exclusion Criteria:

* Those who decline to participate
* Those who are not present in the two days of evaluation.

Primary outcomes:
measure: total reaction time
timeFrame: 6 minutes
Secondary outcomes:
measure: time MoviLetrando
timeFrame: up to 15 days
measure: acerts MoviLetrando
timeFrame: up to 15 days
Other outcomes:
Locations:
city: São Paulo
country: Brazil
facility: Associação de Pais e Amigos dos Excepcionais
Study officials:
References:
Clinical trial NCT02080897: Evaluating Quality of Life in Patients With Soft Tissue Sarcoma Presenting With Metastatic Lung Disease
Official title: Evaluating Quality of Life in Patients With Soft Tissue Sarcoma Presenting With Metastatic Lung Disease Using the ESAS-Sarcoma Modified Questionnaire
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Soft Tissue Sarcoma
Metastatic Lung Disease
Keywords: non-surgical
palliative surgery
Lead sponsor: Duke University
Sponsor class: OTHER
First posted: 2014-03-07
Enrollment: 4
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients presenting with soft tissue sarcoma with metastatic lung disease

Brief summary: The purpose of this study is to evaluate the role of palliative surgery in improving Quality of Life (QoL) and symptom control for patients who present with a Soft Tissue Sarcoma (STS) and metastatic lung disease. Responses to clinical Edmonton Symptom Assessment System - Sarcoma Modified ( ESAS-SM) questionnaire for patients who have undergone surgery for resection of the primary tumour will be compared to those that are unable to have surgery. Data collected from this questionnaire can highlight the benefits in patients' QoL who receive palliative surgical resection, and whether these benefits surmount those who are not treated with palliative surgery.


Eligibility criteria: Inclusion Criteria:

* Patients with soft tissue sarcoma with at least one pulmonary metastasis
* Metastatic lung disease must have been present at time of initial presentation

Exclusion Criteria:

* All patients under 18 will be excluded
* Patients who have been previously undergone surgical resection of the primary tumor

Primary outcomes:
measure: Change in QoL score using patient-response questionnaire
timeFrame: questionnaire will be obtained at initial presentation and at up to 7 additional visits (6 weeks, 3 months, 6 months, 12 months, 24 months, 36 months and 60 months after initial presentation or treatment)
Secondary outcomes:
Other outcomes:
Locations:
city: Durham
country: United States
facility: Duke University Health System
state: North Carolina
Study officials:
affiliation: Duke University
name: William Eward, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03116997: Study of Recovery of Strength After Surgery Comparing Two Different Medications for Reversal of Muscle Relaxant
Official title: Randomized Controlled Assessor Blinded Clinical Trial of Sugammadex Versus Neostigmine /Glycopyrrolate for Reversal of Rocuronium Induced Neuromuscular Blockade: Time to Discharge From Post Anesthesia Care Unit and Patient Satisfaction With Recovery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Surgery
Keywords: neuromuscular blockade
sugammadex
SUG
neostigmine
NEO/GLYCO
17-207
Lead sponsor: Memorial Sloan Kettering Cancer Center
Sponsor class: OTHER
First posted: 2017-04-17
Enrollment: 201
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The purpose of this study is to compare two different medications (neostigmine/glycopyrrolate and sugammadex) to see if one drug improves patient comfort regarding the return of muscle strength after surgery.


Eligibility criteria: Inclusion Criteria:

* Adult patients age 18 years of age or greater who are capable of giving consent
* Undergoing surgical procedures of expected length 6 \</= hours requiring NMB

Exclusion Criteria:

* Pregnancy
* History of documented anaphylaxis or contraindication to any of the study medications
* Active coronary disease with a positive cardiac stress test
* History of severe chronic obstructive pulmonary disease (COPD) defined as an FEV1 \< 50% of predicted
* Serum Creatinine \>/= 2.0 mg/dL
* Severe hepatic dysfunction accompanied by coagulopathy

  * Definition:
  * Known liver Disease AND
  * INR \> 1.5 (except for patients on anticoagulants) AND
  * Platelet count \<100,00/ul without other obvious cause
* Chronic sustained release opioid for \> 2 weeks duration pre op (in the 30 days prior to surgery)
* Use of toremifene
* Significant cognitive impairment or documented psychologic impairment
* Myasthenia gravis or other neuromuscular disease
* Patients who are not eligible for standard anesthetic induction, eg, those needing rapid sequence induction or awake fiberoptic bronchial intubation.
* American Society of Anesthesiologists (ASA) Status \> 3

Primary outcomes:
measure: Measure Participants' Recovery Time Post-Surgery
timeFrame: 1 day
Secondary outcomes:
Other outcomes:
Locations:
city: Basking Ridge
country: United States
facility: Memoral Sloan Kettering Basking Ridge
state: New Jersey
city: Commack
country: United States
facility: Memorial Sloan Kettering Commack
state: New York
city: Harrison
country: United States
facility: Memoral Sloan Kettering Westchester
state: New York
city: New York
country: United States
facility: Memorial Sloan Kettering Cancer Center
state: New York
Study officials:
affiliation: Memorial Sloan Kettering Cancer Center
name: German Echeverry, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00500097: Diabetic Retinopathy and Diabetic Macular Edema Screening by Non-Physicians With Limited Training
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Diabetic Retinopathy
Lead sponsor: Ministry of Health, Thailand
Sponsor class: OTHER_GOV
First posted: 2007-07-12
Enrollment: 840
Sex: ALL
Minimum age (years): 15
Maximum age (years): 80
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NON_RANDOMIZED
Intervention model: FACTORIAL
Primary purpose: SCREENING

Brief summary: The purpose is to assess accuracy of digital retinal image interpretation by technicians and direct ophthalmoscopy by nurses for the determination of diabetic retinopathy severity and the presence of diabetic macular edema for the identification of referrals to ophthalmologists. The results of both screening methods were compared with comprehensive eye examination by ophthalmologists.

Detailed description: Diabetic visual disabilities have increasingly become a global concern since a number of diabetic patients are expected to surge dramatically in the coming decade. Essential means to minimize this problem are detecting vision-threatening diabetic retinopathy early in the course of disease and timely interventions by ophthalmologists.

The American Diabetes Association had issued a guideline for the detection and recommended regular comprehensive eye examination as a preferred method. However, it is not likely that there will be ophthalmologists enough to comprehensively examine the surging number of diabetic patients. Other practical screening methods, such as an interpretation of digital retinal images or direct ophthalmoscopy employed by other health care providers, for identifying the retinopathy for referral to ophthalmologists, should minimize this problem.

Eligibility criteria: Inclusion Criteria:

* diabetic patients defined by WHO criteria
* lived in the geographic area of participated hospitals

Exclusion Criteria:

* have contraindications for receiving mydriatic medications
* have ocular media not clear enough for making diagnosis by any of the screening equipment
* have other retina diseases precluded the diagnosis of diabetic retinopathy

Primary outcomes:
measure: Sensitivity, specificity, kappa coefficient
timeFrame: cross-sectional
Secondary outcomes:
Other outcomes:
Locations:
city: Bangkok
country: Thailand
facility: Department of Ophthalmology, Rajavithi Hospital
Study officials:
affiliation: Department of Ophthalmology, Rajavithi Hospital, Bangkok, Thailand 10400
name: Paisan Ruamviboonsuk, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT06004297: Influence of Combined Double-Bundle ACL Reconstruction With Lateral Retinacular Release to Prevent Patellofemoral Malalignment in Isolated ACL Rupture
Official title: Influence of Combined Double-Bundle ACL Reconstruction With Lateral Retinacular Release to Prevent Patellofemoral Malalignment in Isolated ACL Rupture: a Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: ACL Injury
Lead sponsor: Indonesia University
Sponsor class: OTHER
First posted: 2023-08-22
Enrollment: 100
Sex: ALL
Minimum age (years): 16
Maximum age (years): 40
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Anterior knee pain which might be due to patellofemoral malalignment is an inevitable post operative complication after an ACL reconstruction (ACLR). We combined the double bundle ACLR technique with lateral release technique to prevent patellofemoral malalignment post ACLR.


Eligibility criteria: Inclusion Criteria:

* unilateral isolated total ACL rupture
* normal BMI

Exclusion Criteria:

* flexion contracture more than 200, presence of anterior knee pain before surgery, Q angle \>140 in males and \>170 in females, presence of a patellar tilting, rupture of other ligaments, and muscular dysfunction.

Primary outcomes:
measure: TTTG value
timeFrame: 6 months
Secondary outcomes:
measure: Kujala score
timeFrame: 6 months
Other outcomes:
Locations:
city: Jakarta
country: Indonesia
facility: Faculty of Medicine Universitas Indonesia
Study officials:
References:
Clinical trial NCT06262997: Effectiveness of Pilates and Taping in Office Workers With Neck Pain
Official title: Effectiveness of Pilates and Kinesiotape Applications in Office Workers With Neck Pain
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Neck Pain
Keywords: Neck Pain
Office Workers
Postural Awareness
Quality of Daily Life
Range of Motion
Lead sponsor: Tarsus University
Sponsor class: OTHER
First posted: 2024-02-16
Enrollment: 42
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: One group will receive only pilates training. Other group participants will receive kinesiobant application in addition to pilates training.
Primary purpose: TREATMENT

Brief summary: The aim of this study is to investigate the effectiveness of pilates and kinesiotape applications in office workers with neck pain. In this direction, neck pain and disability, pain threshold, muscle strength, range of motion, core endurance, postural awareness and quality of life will be evaluated.

Detailed description: The aim of this randomized controlled experimental study was to investigate the effectiveness of Pilates and kinesiotape in office workers with neck pain. In this study where a total of 42 office workers will be followed for 8 weeks, individuals will be randomly divided into two groups. The training groups will consist of 3 people each. The control group will receive only Pilates training and the experimental group will receive kinesio taping in addition to Pilates training. Individuals will be analyzed for neck pain and disability, pain threshold, muscle strength, range of motion, core endurance, postural awareness and quality of life.

Eligibility criteria: Inclusion Criteria:

* Have been office workers for at least 1 year
* Using a computer at a desk for at least 3 hours a day
* Having neck pain for more than 6 weeks
* Having neck pain rated at or above 3/10 on a visual analog scale

Exclusion Criteria:

* Having neurological and rheumatologic chronic diseases
* Having received physical therapy in the last 6 months
* Having a history of trauma to the spine
* Having a history of surgery in the cervical spine
* Having diagnosed cervical/lumbar disc and spine pathologies
* Having an allergic reaction to taping

Primary outcomes:
measure: Neck Disability Index
timeFrame: 2 months
Secondary outcomes:
measure: Pain PressureThreshold
timeFrame: 2 months
measure: Muscle Strength
timeFrame: 2 months
measure: Range of Motion
timeFrame: 2 months
measure: Prone Bridge Test
timeFrame: 2 months
measure: Sits Up Test:
timeFrame: 2 months
measure: Postural Habits and Awareness Scale
timeFrame: 2 months
measure: Short Form 36
timeFrame: 2 months
Other outcomes:
Locations:
city: Mersin
country: Turkey
facility: Tarsus University
Study officials:
affiliation: Tarsus University
name: Evrim Göz
role: STUDY_DIRECTOR
References: