Clinical trial NCT06404359: Effects of a Strength Physical Exercise Program in Colorectal Cancer Patients Undergoing Chemotherapy Treatment
Official title: Effects of a Strength Physical Exercise Program in Colorectal Cancer Patients Undergoing Chemotherapy Treatment
Study type: INTERVENTIONAL
Overall status: NOT_YET_RECRUITING
Phase: NA
Conditions: Oncology
Chemotherapy-induced Peripheral Neuropathy
Keywords: Exercise
Physiotherapy
Lead sponsor: University of Salamanca
Sponsor class: OTHER
First posted: 2024-05-08
Enrollment: 40
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: PREVENTION

Brief summary: Chemotherapy is a crucial treatment in the fight against colon cancer, but unfortunately, its impact is not limited to cancer cells alone. Chemotherapy drugs, designed to attack fast-growing cells, also affect healthy tissues, leading to various side effects. One of the most common adverse effects is peripheral neuropathy, a condition that affects the peripheral nerves and can manifest as tingling sensations, numbness, pain or weakness in the extremities.

Chemotherapy-induced peripheral neuropathy can be especially challenging for colon cancer patients, as it further aggravates quality of life during an already difficult period. Nerves responsible for motor and sensory function are compromised, affecting the patient's ability to perform daily activities and weakening their physical endurance. This phenomenon adds to the emotional and physical burden of fighting cancer.

However, there are tools that can positively influence these adverse effects, such as physical exercise. Although it may seem contradictory, regular physical exercise has been shown to have beneficial effects on peripheral neuropathy. Physical exercise can improve blood circulation and promote regeneration of damaged peripheral nerves. In addition, exercise helps to alleviate the pain and discomfort associated with neuropathy, thereby strengthening patients' functional capacity.

It is essential to emphasize that any exercise plan must be tailored to the individual capabilities of each patient, and medical supervision is essential. Therefore, the combination of chemotherapy and carefully planned physical exercise offers a comprehensive strategy to address both the disease and its side effects, providing colon cancer patients with a better quality of life during their journey to recovery.


Eligibility criteria: Inclusion Criteria:

* People diagnosed with colorectal cancer and who are receiving chemotherapy treatment.
* Sedentary people who have not performed physical activity in the last 8 weeks.
* Ability to understand the evaluation tests and the performance of the exercises.
* Presence of XXX symptoms (If we focus on neuropathy, it should be inclusion criteria).
* Voluntary participation in the study.

Exclusion Criteria:

- Present contraindication/s for physical exercise (musculoskeletal diseases, severe cardiovascular disease, bone metastases,...).

Primary outcomes:
measure: Chemotherapy-induced neuropathy
timeFrame: Baseline and immediately after the intervention
Secondary outcomes:
measure: Wellbeing
timeFrame: Baseline and immediately after the intervention
measure: Body Mass Index
timeFrame: Baseline and immediately after the intervention
measure: Oxygen consumption
timeFrame: Before and after the intervention
measure: Anxiety and depression
timeFrame: Baseline and immediately after the intervention
measure: Fatigue
timeFrame: Baseline and immediately after the intervention
measure: Sleep quality
timeFrame: Baseline and immediately after the intervention
measure: Sex
timeFrame: Baseline
measure: Heighth
timeFrame: Baseline
Other outcomes:
Locations:
Study officials:
References: