Clinical trial NCT03647397: PECO Air Purification in Hospital Rooms to Improve Health Outcomes for Pediatric Respiratory Distress
Official title: Use of PECO Air Purification in Hospital Rooms to Improve Health Outcomes for Pediatric Respiratory Distress
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Asthma
Pneumonia
Respiratory Distress Syndrome
Keywords: asthma
environmental intervention
respiratory distress
pediatric hospitalization
pneumonia
bronchiolitis
Lead sponsor: Molekule
Sponsor class: INDUSTRY
Collaborators: name: Mercy Health System
First posted: 2018-08-27
Enrollment: 274
Sex: ALL
Minimum age (years): 1
Maximum age (years): 17
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: PREVENTION

Brief summary: This study will investigate the efficacy of a novel air purification technology, Photo Electrochemical Oxidation (PECO), has on pediatric patients hospitalized for respiratory distress. The study will take place at Mercyhealth Hospital - Rockton Avenue where all 23 pediatric rooms will be outfitted with portable PECO air purifying units. The main outcomes are the length of stay and progression to ICU, which will be compared with historical controls.

Detailed description: The goal of this study is to assess whether using PECO to purify air in a hospital can improve health outcomes for pediatric patients with respiratory distress.

The results of this study will be used in three primary ways:

1. As evidence to support an installation of PECO in hospital HVAC systems to improve the standard of care for patients with respiratory distress
2. Towards dissemination efforts through publication in a peer-reviewed journal and presentation at national and international conferences
3. For informing healthcare providers and stakeholders

There are no plans to repeat this study with other hospital partners

Eligibility criteria: Inclusion Criteria: All pediatric patients who are admitted to the Mercyhealth Hospital - Rockton Avenue following the Start Date and have infectious or non-infectious respiratory distress as defined by the following ICD codes will be included in the study:

* J00-J06: Acute upper respiratory infections
* J09-J18: Influenza and pneumonia
* J20-J22: Other acute lower respiratory infections
* J30-J39: Other diseases of upper respiratory tract
* J40-J47: Chronic lower respiratory diseases
* J60-J70: Lung diseases due to external agents
* J80-J84: Other respiratory diseases principally affecting the interstitium
* J85-J86: Suppurative and necrotic conditions of the lower respiratory tract
* J90-J94: Other diseases of the pleura
* J95-J95: Intraoperative and postprocedural complications and disorders of respiratory system, not elsewhere classified

Exclusion Criteria:

* Any patient admitted to the NICU
* Patients in the ER only
* Any patient with non-respiratory conditions
* Adults

Primary outcomes:
measure: Length of stay
timeFrame: 5 months
Secondary outcomes:
measure: Readmission rate
timeFrame: 1 months
Other outcomes:
Locations:
city: Rockford
country: United States
facility: Mercyhealth Hospital - Rockton Avenue
state: Illinois
Study officials:
affiliation: Molekule
name: Nikhil Rao
role: PRINCIPAL_INVESTIGATOR
References: