Clinical trial NCT03345849: A Study of the Efficacy and Safety of Upadacitinib in Participants With Moderately to Severely Active Crohn's Disease Who Have Inadequately Responded to or Are Intolerant to Conventional and/or Biologic Therapies
Official title: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Induction Study of the Efficacy and Safety of Upadacitinib (ABT-494) in Subjects With Moderately to Severely Active Crohn's Disease Who Have Inadequately Responded to or Are Intolerant to Conventional and/or Biologic Therapies
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: PHASE3
Conditions: Crohn's Disease
Keywords: Upadacitinib
ABT-494
Efficacy
Safety
Crohn's Disease
Lead sponsor: AbbVie
Sponsor class: INDUSTRY
First posted: 2017-11-17
Enrollment: 526
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: The objective of this study is to evaluate the efficacy and safety of upadacitinib compared to placebo as induction therapy in adults with moderately and severely active Crohn's disease (CD).

Detailed description: This study includes two parts:

* Part 1: a randomized double-blind placebo-controlled induction period and
* Part 2: an extended treatment period for non-responders from Part 1.

In Part 1, participants will be randomized in a 2:1 ratio to upadacitinib 45 mg once daily (QD) or matching placebo for 12 weeks. The randomization will be stratified by baseline corticosteroid use (yes or no), endoscopic disease severity (Simplified Endoscopic Score for Crohn's disease \[SES-CD\] \< 15 and ≥ 15), and number of prior biologics with prior inadequate response or intolerance (0, 1, \> 1).

Participants who do not achieve clinical response at Week 12 will be able to enroll in Part 2 to receive a double-blind extended treatment with upadacitinib until Week 24. Clinical response is defined as a ≥ 30% decrease in average daily very soft or liquid stool frequency (SF) and/or ≥ 30% decrease in average daily abdominal pain (AP) score (both not worse than Baseline).

Participants who achieve clinical response at Week 12 may be eligible to enter the 52-week, double-blind, maintenance portion of Study M14-430 (NCT03345823).

Eligibility criteria: Inclusion Criteria:

* Confirmed diagnosis of CD for at least 3 months prior to Baseline.
* Confirmed diagnosis of moderate to severe CD as assessed by stool frequency (SF), abdominal pain (AP) score.
* Evidence of mucosal inflammation based on the Simplified Endoscopic Score for Crohn's disease (SES-CD) on an endoscopy confirmed by a central reader.
* Demonstrated an inadequate response or intolerance to one or more conventional and/or biologic therapies (oral locally acting steroids, intravenous or oral corticosteroids, immunosuppressants or biologic therapies for CD), in the opinion of the investigator.

  * Note: Participants who have had inadequate response or intolerance to conventional therapy who have received prior biologic may be enrolled; however, participants must have discontinued the biologic for reasons other than inadequate response or intolerance (e.g., change of insurance, well controlled disease).
* If female, participant must meet the contraception recommendations.

Exclusion Criteria:

* Participant with a current diagnosis of ulcerative colitis or indeterminate colitis.
* Participant not on stable doses of CD related antibiotics, oral aminosalicylates, corticosteroids or methotrexate (MTX).
* Participant with the following ongoing known complications of CD: abscess (abdominal or peri-anal), symptomatic bowel strictures, fulminant colitis, toxic megacolon, \> 2 entire missing segments of the following 5 segments: terminal ileum, right colon, transverse colon, sigmoid and left colon, and rectum, or any other manifestation that might require surgery while enrolled in the study.
* Participant with ostomy or ileoanal pouch.
* Participant diagnosed with conditions that could interfere with drug absorption including but not limited to short gut or short bowel syndrome.
* Screening laboratory and other analyses show abnormal results.

Primary outcomes:
measure: Percentage of Participants With Clinical Remission Per Crohn's Disease Activity Index (CDAI) at Week 12
timeFrame: Week 12
measure: Percentage of Participants With Clinical Remission Per Patient-Reported Outcomes (PROs) at Week 12
timeFrame: Week 12
measure: Percentage of Participants With Endoscopic Response at Week 12
timeFrame: Baseline and Week 12
Secondary outcomes:
measure: Percentage of Participants With Endoscopic Remission at Week 12
timeFrame: Baseline and Week 12
measure: Percentage of Participants Who Discontinued Corticosteroid Use for Crohn's Disease and Achieved Clinical Remission Per CDAI at Week 12
timeFrame: Week 12
measure: Change From Baseline in Functional Assessment of Chronic Illness Therapy - Fatigue (FACIT-Fatigue) at Week 12
timeFrame: Baseline and Week 12
measure: Change From Baseline in Inflammatory Bowel Disease Questionnaire (IBDQ) Total Score at Week 12
timeFrame: Baseline and Week 12
measure: Percentage of Participants Achieving Clinical Response 100 (CR-100) at Week 2
timeFrame: Baseline and Week 2
measure: Percentage of Participants Achieving Clinical Response 100 (CR-100) at Week 12
timeFrame: Baseline and Week 12
measure: Percentage of Participants With Clinical Remission Per CDAI at Week 4
timeFrame: Week 4
measure: Percentage of Participants With Hospitalizations Due to Crohn's Disease (CD) During the 12-Week Induction Period
timeFrame: 12 weeks
measure: Percentage of Participants With Resolution of Extra-Intestinal Manifestation (EIMs) at Week 12
timeFrame: Week 12
measure: Percentage of Participants With Clinical Remission Per PROs at Week 4
timeFrame: Week 4
measure: Percentage of Participants Who Discontinued Corticosteroid Use for Crohn's Disease and Achieved Clinical Remission Per PROs at Week 12
timeFrame: Week 12
Other outcomes:
Locations:
city: Mobile
country: United States
facility: East View Medical Research, LLC /ID# 171176
state: Alabama
city: Mobile
country: United States
facility: CB Flock Research Corporation /ID# 166185
state: Alabama
city: Chandler
country: United States
facility: Delsol Research Management, Ll /Id# 170145
state: Arizona
city: Scottsdale
country: United States
facility: HonorHealth Research Institute - Shea /ID# 164821
state: Arizona
city: Sun City
country: United States
facility: Arizona Arthritis & Rheumatology Research, PLLC /ID# 164803
state: Arizona
city: Coronado
country: United States
facility: Southern California Res. Ctr. /ID# 169655
state: California
city: Covina
country: United States
facility: Citrus Valley Gastroenterology /ID# 166173
state: California
city: Irvine
country: United States
facility: Hoag Memorial Hosp Presbyterian /ID# 222540
state: California
city: Los Alamitos
country: United States
facility: United Medical Doctors /ID# 207449
state: California
city: Los Angeles
country: United States
facility: Gastrointestinal Biosciences Clinical Trials, LLC /ID# 164762
state: California
city: Mission Hills
country: United States
facility: Facey Medical Foundation /ID# 203136
state: California
city: Murrieta
country: United States
facility: United Medical Doctors - Murrieta /ID# 164945
state: California
city: San Diego
country: United States
facility: Ucsd /Id# 164910
state: California
city: San Diego
country: United States
facility: Medical Assoc Research Grp /ID# 169706
state: California
city: San Francisco
country: United States
facility: Univ of California San Francis /ID# 164944
state: California
city: San Pablo
country: United States
facility: Care Access Research /ID# 167767
state: California
city: Colorado Springs
country: United States
facility: Peak Gastroenterology Associates, PC /ID# 170143
state: Colorado
city: Colorado Springs
country: United States
facility: Delta Waves, Inc. /ID# 164776
state: Colorado
city: Wheat Ridge
country: United States
facility: Western States Clinical Res /ID# 164760
state: Colorado
city: Hamden
country: United States
facility: Medical Research Center of CT /ID# 164926
state: Connecticut
city: Clearwater
country: United States
facility: Clinical Research of West Florida, Inc /ID# 205827
state: Florida
city: Clearwater
country: United States
facility: Clinical Research of West Florida, Inc /ID# 208118
state: Florida
city: Coral Springs
country: United States
facility: Advanced Research - Coral Springs /ID# 218021
state: Florida
city: Jacksonville
country: United States
facility: Encore Borland-Groover Clinical Research /Id# 203499
state: Florida
city: Maitland
country: United States
facility: Ctr for Advanced Gastroenterol /ID# 165353
state: Florida
city: Miami
country: United States
facility: Crystal Pharmacology Research /ID# 166081
state: Florida
city: Miami
country: United States
facility: Coral Research Clinic /ID# 164890
state: Florida
city: New Port Richey
country: United States
facility: Advanced Research Institute, Inc /ID# 164921
state: Florida
city: Orlando
country: United States
facility: Endoscopic Research, Inc. /ID# 206136
state: Florida
city: Orlando
country: United States
facility: Omega Research Maitland, LLC /ID# 203481
state: Florida
city: Tampa
country: United States
facility: Clinical Research Trials of Florida, Inc. /ID# 203485
state: Florida
city: Tampa
country: United States
facility: AdventHealth Tampa /ID# 171167
state: Florida
city: Macon
country: United States
facility: Gastroenterology Associates of Central Georgia, LLC /ID# 165478
state: Georgia
city: Roswell
country: United States
facility: Gastroenterology Consultants PC - Roswell /ID# 218220
state: Georgia
city: Suwanee
country: United States
facility: Atlanta Gastroenterology Spec /ID# 164799
state: Georgia
city: Boise
country: United States
facility: Treasure Valley Medical Research /ID# 215032
state: Idaho
city: Chicago
country: United States
facility: Rush University Medical Center /ID# 165497
state: Illinois
city: Chicago
country: United States
facility: University of Chicago Medicine /ID# 165503
state: Illinois
city: Downers Grove
country: United States
facility: DuPage Medical Group /ID# 205328
state: Illinois
city: Evansville
country: United States
facility: MediSphere Medical Research Center /ID# 166175
state: Indiana
city: Indianapolis
country: United States
facility: Indianapolis Gastroenterology /ID# 164938
state: Indiana
city: Iowa City
country: United States
facility: University of Iowa Hospitals and Clinics /ID# 165436
state: Iowa
city: Crestview Hills
country: United States
facility: Tri-State Gastroenterology /ID# 165496
state: Kentucky
city: Louisville
country: United States
facility: University of Louisville /ID# 165366
state: Kentucky
city: Louisville
country: United States
facility: University of Louisville /ID# 168572
state: Kentucky
city: Houma
country: United States
facility: CroNOLA, LLC /ID# 164823
state: Louisiana
city: New Orleans
country: United States
facility: Nola Research Works, LLC /ID# 164759
state: Louisiana
city: Shreveport
country: United States
facility: Louisana Research Center, LLC /ID# 164894
state: Louisiana
city: Baltimore
country: United States
facility: Johns Hopkins University School of Medicine /ID# 211941
state: Maryland
city: Chevy Chase
country: United States
facility: MGG Group Co, Inc.Chevy Chase Clinical Research /ID# 164935
state: Maryland
city: Columbia
country: United States
facility: Gastro Center of Maryland /ID# 171161
state: Maryland
city: Burlington
country: United States
facility: Lahey Hospital and Medical Center /ID# 214726
state: Massachusetts
city: Ann Arbor
country: United States
facility: University of Michigan Comprehensive Cancer Center Michigan Medicine /ID# 164943
state: Michigan
city: Farmington Hills
country: United States
facility: Digestive Health Associates (DHA) - Farmington Hills /ID# 205793
state: Michigan
city: Troy
country: United States
facility: Center for Digestive Health /ID# 164822
state: Michigan
city: Troy
country: United States
facility: Clin Res Inst of Michigan, LLC /ID# 170133
state: Michigan
city: Rochester
country: United States
facility: Mayo Clinic - Rochester /ID# 164783
state: Minnesota
city: Jackson
country: United States
facility: Southern Therapy and Advanced Research (STAR) LLC /ID# 165343
state: Mississippi
city: Omaha
country: United States
facility: Quality Clinical Research Inc. /ID# 170137
state: Nebraska
city: Omaha
country: United States
facility: Duplicate_CHI Nebraska d/b/a CHI Health /ID# 168578
state: Nebraska
city: Las Vegas
country: United States
facility: Las Vegas Medical Research /ID# 168588
state: Nevada
city: Egg Harbor Township
country: United States
facility: AGA Clinical Research Associates, LLC /ID# 164769
state: New Jersey
city: New Brunswick
country: United States
facility: Rutgers Robert Wood Johnson /ID# 166073
state: New Jersey
city: Bronx
country: United States
facility: Montefiore Medical Center - Moses Campus /ID# 166193
state: New York
city: Bronx
country: United States
facility: Advantage Clinical Trials /ID# 168546
state: New York
city: Brooklyn
country: United States
facility: NY Scientific /ID# 164931
state: New York
city: Johnson City
country: United States
facility: United Health Services Hospitals, Inc /ID# 217485
state: New York
city: Lake Success
country: United States
facility: NYU Langone Long Island Clinical Research Associates /ID# 164927
state: New York
city: New York
country: United States
facility: The Mount Sinai Hospital /ID# 170257
state: New York
city: New York
country: United States
facility: Columbia Univ Medical Center /ID# 164782
state: New York
city: Rochester
country: United States
facility: Gastoenterology Group of Rochester /ID# 166177
state: New York
city: Staten Island
country: United States
facility: Richmond University Medical Center /ID# 201857
state: New York
city: Charlotte
country: United States
facility: Atrium Health Carolinas Medical Center /ID# 164932
state: North Carolina
city: Charlotte
country: United States
facility: PMG Research of Charlotte /ID# 171160
state: North Carolina
city: Raleigh
country: United States
facility: Wake Radiology UNC REX Healthcare - Raleigh Office /ID# 164904
state: North Carolina
city: Winston-Salem
country: United States
facility: Wake Forest Baptist Medical Center /ID# 164908
state: North Carolina
city: Fargo
country: United States
facility: Plains Clinical Research Center, LLC /ID# 170140
state: North Dakota
city: Cincinnati
country: United States
facility: Gastro Health Research /ID# 164791
state: Ohio
city: Cincinnati
country: United States
facility: University of Cincinnati /ID# 164825
state: Ohio
city: Cleveland
country: United States
facility: Cleveland Clinic Main Campus /ID# 209231
state: Ohio
city: Columbus
country: United States
facility: The Ohio State University /ID# 170141
state: Ohio
city: Columbus
country: United States
facility: Optimed Research, Ltd. /ID# 205624
state: Ohio
city: Dayton
country: United States
facility: Hometown Urgent Care and Resea /ID# 201291
state: Ohio
city: Englewood
country: United States
facility: Dayton Gastroenterology, Inc. /ID# 167627
state: Ohio
city: Mentor
country: United States
facility: Great Lakes Medical Research, LLC /ID# 202010
state: Ohio
city: Oklahoma City
country: United States
facility: Digestive Disease Specialists /ID# 201064
state: Oklahoma
city: Tulsa
country: United States
facility: Options Health Research, LLC /ID# 164820
state: Oklahoma
city: Tulsa
country: United States
facility: Healthcare Research Consultant /ID# 166195
state: Oklahoma
city: Philadelphia
country: United States
facility: University of Pennsylvania /ID# 168430
state: Pennsylvania
city: Charleston
country: United States
facility: Pharmacorp Clinical Trials /ID# 164916
state: South Carolina
city: Greenville
country: United States
facility: Gastroenterology Associates, P.A. of Greenville /ID# 164771
state: South Carolina
city: Rapid City
country: United States
facility: Rapid City Medical Center - GI Research /ID# 201735
state: South Dakota
city: Germantown
country: United States
facility: Gastro One /ID# 164826
state: Tennessee
city: Johnson City
country: United States
facility: East Tennessee Research Institute /ID# 203613
state: Tennessee
city: Nashville
country: United States
facility: Quality Medical Research /ID# 205263
state: Tennessee
city: Nashville
country: United States
facility: Vanderbilt University Medical Center /ID# 164946
state: Tennessee
city: Arlington
country: United States
facility: TX Clinical Research Institute /ID# 164896
state: Texas
city: Baytown
country: United States
facility: Inquest Clinical Research /ID# 164785
state: Texas
city: Cedar Park
country: United States
facility: Texas Digestive Disease Consultants /ID# 209953
state: Texas
city: Cedar Park
country: United States
facility: Texas Digestive Disease Consultants /ID# 209801
state: Texas
city: Dallas
country: United States
facility: Baylor Scott & White Center for Inflammatory Bowel Diseases /ID# 170144
state: Texas
city: Houston
country: United States
facility: CliniCore International, LLC /ID# 164902
state: Texas
city: Houston
country: United States
facility: Baylor College of Medicine - Baylor Medical Center /ID# 164947
state: Texas
city: Houston
country: United States
facility: Centex Studies, Inc. - Houston /ID# 201214
state: Texas
city: Houston
country: United States
facility: GI Specialists of Houston /ID# 202339
state: Texas
city: Lubbock
country: United States
facility: Caprock Gastro Research, LLC /ID# 215438
state: Texas
city: San Antonio
country: United States
facility: Clinical Associates in Research Therapeutics of America, LLC /ID# 164786
state: Texas
city: San Antonio
country: United States
facility: Southern Star Research Institute, LLC /ID# 169755
state: Texas
city: Sugar Land
country: United States
facility: Carl R. Meisner Medical Clinic /ID# 201061
state: Texas
city: Tyler
country: United States
facility: Tyler Research Institute, LLC /ID# 168687
state: Texas
city: Victoria
country: United States
facility: Gastro Health & Nutrition - Victoria /ID# 167812
state: Texas
city: Bountiful
country: United States
facility: HP Clinical Research /ID# 164933
state: Utah
city: Ogden
country: United States
facility: Advanced Research Institute /ID# 164784
state: Utah
city: Salt Lake City
country: United States
facility: Duplicate_Care Access Research /ID# 164794
state: Utah
city: West Jordan
country: United States
facility: Velocity Clinical Research - Salt Lake City /ID# 166076
state: Utah
city: Bellevue
country: United States
facility: Washington Gastroenterology /ID# 164824
state: Washington
city: Seattle
country: United States
facility: Virginia Mason Medical Center /ID# 164913
state: Washington
city: Vancouver
country: United States
facility: The Vancouver Clinic, INC. PS /ID# 164918
state: Washington
city: Wauwatosa
country: United States
facility: Allegiance Research Specialists /ID# 165346
state: Wisconsin
city: San Isidro
country: Argentina
facility: Cardio Alem /ID# 211285
state: Buenos Aires
city: Ciudad Autonoma Buenos Aires
country: Argentina
facility: Hospital Italiano de Buenos Aires /ID# 215541
state: Ciuadad Autonoma De Buenos Aires
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: Gedyt /ID# 210020
state: Ciuadad Autonoma De Buenos Aires
city: Ciudad Autonoma de Buenos Aire
country: Argentina
facility: Cemic /Id# 169182
state: Ciuadad Autonoma De Buenos Aires
city: Rosario
country: Argentina
facility: Hospital Provincial del Centenario /ID# 171252
state: Santa Fe
city: Cordoba
country: Argentina
facility: Hospital Privado Univesitario /ID# 169230
city: Concord
country: Australia
facility: Concord Repatriation General Hospital /ID# 171512
state: New South Wales
city: North Mackay
country: Australia
facility: Coral Sea Clinical Research institute /ID# 212988
state: Queensland
city: South Brisbane
country: Australia
facility: Mater Misericordiae Limited /ID# 204909
state: Queensland
city: Adelaide
country: Australia
facility: Royal Adelaide Hospital /ID# 171514
state: South Australia
city: Box Hill
country: Australia
facility: Box Hill Hospital /ID# 203736
state: Victoria
city: Murdoch
country: Australia
facility: Fiona Stanley Hospital /ID# 171513
state: Western Australia
city: Vienna
country: Austria
facility: Medizinische Universitaet Wien /ID# 169465
state: Wien
city: Salzburg
country: Austria
facility: Landeskrankenhaus Salzburg-Universitätsklinikum der PMU (LKH) /ID# 214470
city: Woluwe-Saint-Lambert
country: Belgium
facility: UCL Saint-Luc /ID# 200303
state: Bruxelles-Capitale
city: Liège
country: Belgium
facility: CHU de Liege Sart Tilman /ID# 217534
state: Liege
city: Gent
country: Belgium
facility: AZ Sint-Lucas /ID# 200302
city: Banja Luka
country: Bosnia and Herzegovina
facility: University Clinical Centre of the Republic of Srpska /ID# 208051
state: Republika Srpska
city: Tuzla
country: Bosnia and Herzegovina
facility: University Clinical Center Tuzla /ID# 210325
state: Tuzlanski
city: Sarajevo
country: Bosnia and Herzegovina
facility: Clinical Center University of Sarajevo /ID# 203887
city: Sarajevo
country: Bosnia and Herzegovina
facility: Polyclinic and Daily Hospital Dr. Al-Tawil /ID# 217842
city: Goiânia
country: Brazil
facility: Instituto Goiano de Gastroenterologia e Endoscopia Digestiva /ID# 166852
state: Goias
city: Curitiba
country: Brazil
facility: Hospital Nossa Senhora das Graças /ID# 166863
state: Parana
city: Porto Alegre
country: Brazil
facility: Hospital de Clinicas de Porto Alegre /ID# 166862
state: Rio Grande Do Sul
city: Botucatu
country: Brazil
facility: Upeclin Fmb - Unesp /Id# 166867
state: Sao Paulo
city: Ribeirão Preto
country: Brazil
facility: Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto - USP /ID# 166866
state: Sao Paulo
city: Santo André
country: Brazil
facility: Faculdade de Medicina do ABC /ID# 208323
state: Sao Paulo
city: Sao Jose Do Rio Preto
country: Brazil
facility: Kaiser Clinica e Hospital Dia /ID# 166865
state: Sao Paulo
city: Plovdiv
country: Bulgaria
facility: UMHAT Kaspela EOOD /ID# 167613
city: Sofia
country: Bulgaria
facility: Duplicate_Second MHAT Sofia /ID# 167614
city: Stara Zagora
country: Bulgaria
facility: MHAT Trakia /ID# 201679
city: Calgary
country: Canada
facility: University of Calgary /ID# 166974
state: Alberta
city: Edmonton
country: Canada
facility: Allen Whey Khye Lim Professional Corporation /ID# 168044
state: Alberta
city: Edmonton
country: Canada
facility: University of Alberta - Zeidler Ledcor Centre /ID# 166971
state: Alberta
city: Edmonton
country: Canada
facility: South Edmonton Gastroenterology Research Clinic /ID# 166978
state: Alberta
city: New Westminster
country: Canada
facility: Fraser Clinical Trials Inc /ID# 166968
state: British Columbia
city: Vancouver
country: Canada
facility: GIRI Gastrointestinal Research Institute /ID# 166975
state: British Columbia
city: Halifax
country: Canada
facility: QEII - Health Sciences Centre /ID# 169307
state: Nova Scotia
city: London
country: Canada
facility: London Health Sciences Center /ID# 221038
state: Ontario
city: North Bay
country: Canada
facility: Scott Shulman Medicine Professional Corporation /ID# 169066
state: Ontario
city: Oshawa
country: Canada
facility: Taunton Surgical Centre /ID# 168043
state: Ontario
city: Ottawa
country: Canada
facility: Ottawa Hospital Research Institute /ID# 212414
state: Ontario
city: Sudbury
country: Canada
facility: Medicor Research Inc /ID# 166979
state: Ontario
city: Vaughan
country: Canada
facility: Toronto Digestive Disease Asso /ID# 166972
state: Ontario
city: Levis
country: Canada
facility: CISSS de Chaudière-Appalaches, Hôpital Hotel-Dieu de Lévis /ID# 166969
state: Quebec
city: Montreal
country: Canada
facility: Centre Hospitalier de l'Universite de Montreal - CRCHUM /ID# 170120
state: Quebec
city: Montreal
country: Canada
facility: Royal Victoria Hospital / McGill University Health Centre /ID# 170119
state: Quebec
city: Sherbrooke
country: Canada
facility: CIUSSS de l'Estrie - CHUS /ID# 170940
state: Quebec
city: Santiago
country: Chile
facility: Research Group /ID# 203179
state: Region Metropolitana De Santiago
city: Santiago
country: Chile
facility: M y F Estudios Clínicos /ID# 169984
state: Region Metropolitana Santiago
city: Concepción
country: Chile
facility: Hospital Guillermo Grant Benavente de Concepción /ID# 212423
city: Providencia
country: Chile
facility: CTR Estudios Clinicos /ID# 203941
city: Santiago
country: Chile
facility: Hospital Clinico Universidad De Los Andes /ID# 207466
city: Xiamen
country: China
facility: Zhongshan Hospital Xiamen University /ID# 204984
state: Fujian
city: Guangzhou
country: China
facility: The First Affiliated Hospital, Sun Yat-sen University /ID# 205228
state: Guangdong
city: Guangzhou
country: China
facility: Nanfang Hospital of Southern Medical University /ID# 204083
state: Guangdong
city: Guangzhou
country: China
facility: The Sixth Affiliated Hosp Sun /ID# 204077
state: Guangdong
city: Wuhan
country: China
facility: Union Hospital Tongji Medical College Huazhong University of Science and Technol /ID# 204081
state: Hubei
city: Nanjing
country: China
facility: Nanjing Drum Tower Hospital /ID# 204900
state: Jiangsu
city: Nanchang
country: China
facility: The First Affiliated Hospital of Nanchang University /ID# 204092
state: Jiangxi
city: Changchun
country: China
facility: The First Hospital of Jilin University /ID# 206868
state: Jilin
city: Shanghai
country: China
facility: Ruijin Hospital, Shanghai Jiaotong University School of Medicine /ID# 204091
state: Shanghai
city: Hangzhou
country: China
facility: The second Affiliated hospital of Zhejiang University school of Medicine /ID# 204073
state: Zhejiang
city: Hangzhou
country: China
facility: Sir Run Run Shaw Hospital,Meical School Zhejiang University /ID# 204076
state: Zhejiang
city: Beijing
country: China
facility: Beijing Friendship Hospital /ID# 204173
city: Changsha
country: China
facility: The Second Xiangya Hospital of Central South University /ID# 204082
city: Tianjin
country: China
facility: Duplicate_Tianjin Med Univ General Hosp /ID# 206994
city: Wuhan
country: China
facility: Tongji Hospital Tongji Medical College of HUST /ID# 204088
city: Medellín
country: Colombia
facility: Hospital Pablo Tobon Uribe /ID# 202404
state: Antioquia
city: Medellin
country: Colombia
facility: Hospital Universitario San Vic /ID# 200029
city: Zagreb
country: Croatia
facility: Clinical Hospital Dubrava /ID# 171185
state: Grad Zagreb
city: Zagreb
country: Croatia
facility: Klinicki bolnicki centar Sestre milosrdnice /ID# 205535
state: Grad Zagreb
city: Zagreb
country: Croatia
facility: Klinicki bolnicki centar Zagreb /ID# 171203
state: Grad Zagreb
city: Zagreb
country: Croatia
facility: Poliklinika Solmed /ID# 211519
state: Grad Zagreb
city: Split
country: Croatia
facility: UHC Split /ID# 171191
city: Zadar
country: Croatia
facility: Zadar General Hospital /ID# 205536
city: Ceske Budejovice
country: Czechia
facility: Nemocnice Ceske Budejovice a.s. /ID# 224389
city: Hradec Kralove
country: Czechia
facility: Hepato-Gastroenterologie HK, s.r.o. /ID# 171401
city: Ostrava
country: Czechia
facility: ARTROSCAN s.r.o. /ID# 200790
city: Praha
country: Czechia
facility: ResTrial s.r.o. /ID# 208653
city: Herlev
country: Denmark
facility: Herlev Hospital /ID# 202423
state: Hovedstaden
city: Hilleroed
country: Denmark
facility: Nordsjaellands Hospital /ID# 202424
state: Hovedstaden
city: Hvidovre
country: Denmark
facility: Kobenhavns Universitet - Hvidovre Hospital (HH) /ID# 202425
state: Hovedstaden
city: Roskilde
country: Denmark
facility: Duplicate_Sjaellands Universitets Hospital /ID# 209445
state: Sjælland
city: Alexandria
country: Egypt
facility: Clinical Research Center, Faculty of Medicine, Alexandria university. /ID# 171012
city: Alexandria
country: Egypt
facility: Clinical Research Center, Faculty of Medicine, Alexandria university. /ID# 171013
city: Alexandria
country: Egypt
facility: Clinical Research Center, Faculty of Medicine, Alexandria university. /ID# 209564
city: Cairo
country: Egypt
facility: National Hepatology and Tropical Medicine Research Institute /ID# 170989
city: Cairo
country: Egypt
facility: Air Force Specialized Hospital /ID# 170996
city: Menoufiya
country: Egypt
facility: National Liver Institute /ID# 170988
city: Tallinn
country: Estonia
facility: West Tallinn Central Hospital /ID# 202785
city: La Tronche
country: France
facility: CHU Grenoble - Hopital Michallon /ID# 219034
city: Nantes
country: France
facility: Clinique Jules Verne /ID# 219073
city: Valenciennes
country: France
facility: CH Valenciennes /ID# 219035
city: Mannheim
country: Germany
facility: Universitatsklinikum Mannheim /ID# 168759
state: Baden-Wuerttemberg
city: Ulm
country: Germany
facility: Universitaetsklinikum Ulm /ID# 203560
state: Baden-Wuerttemberg
city: Erlangen
country: Germany
facility: Universitaetsklinikum Erlangen /ID# 203552
state: Bayern
city: Frankfurt am Main
country: Germany
facility: Universitaetsklinikum Frankfurt /ID# 203566
state: Hessen
city: Saarbrücken
country: Germany
facility: Zentrum für Gastroenterologie Saar MVZ GmbH /ID# 206741
state: Saarland
city: Kiel
country: Germany
facility: Universitaetsklinikum Schleswig-Holstein Campus Kiel /ID# 168757
state: Schleswig-Holstein
city: Berlin
country: Germany
facility: Gastroenterologie am Mexikoplatz /ID# 203575
city: Essen
country: Germany
facility: Universitaetsmedizin Essen St. Josef Krankenhaus Werden /ID# 203570
city: Frankfurt am Main
country: Germany
facility: Agaplesion Markus Krankenhaus /ID# 168758
city: Halle (Saale)
country: Germany
facility: Universitaetsklinikum Halle (Saale) /ID# 207455
city: Muenster
country: Germany
facility: Medizinisches Versorgungszentrum Portal 10 /ID# 200214
city: Athens
country: Greece
facility: General Hospital of Athens Ippokratio /ID# 167045
state: Attiki
city: Athens
country: Greece
facility: General Hospital of Chest Diseases of Athens SOTIRIA /ID# 202104
state: Attiki
city: Piraeus
country: Greece
facility: Tzaneio general hospital of Piraeus /ID# 206433
state: Attiki
city: Heraklion
country: Greece
facility: University General Hospital of Heraklion PA.G.N.I /ID# 167044
state: Kriti
city: Thessaloniki
country: Greece
facility: General Hospital of Thessaloniki Hippokrateio /ID# 208825
city: Hong Kong
country: Hong Kong
facility: Tuen Mun Hospital /ID# 171218
city: Mohacs
country: Hungary
facility: Mohacsi Korhaz /ID# 209441
state: Baranya
city: Encs
country: Hungary
facility: CRU Hungary Egeszsegugyi és Szolgaltato Kft. /ID# 205547
state: Borsod-Abauj-Zemplen
city: Debrecen
country: Hungary
facility: Debreceni Egyetem Klinikai Kozpont /ID# 216419
state: Hajdu-Bihar
city: Gyöngyös
country: Hungary
facility: Bugat Pal Korhaz /ID# 201893
state: Heves
city: Tatabanya
country: Hungary
facility: Szent Borbala Korhaz /ID# 209897
state: Komarom-Esztergom
city: Budapest
country: Hungary
facility: Obudai Egeszsegugyi Centrum Kft. /ID# 201892
state: Pest
city: Budapest
country: Hungary
facility: Semmelweis Egyetem /ID# 210167
city: Budapest
country: Hungary
facility: Magyar Honvedseg Egeszsegugyi Kozpont /ID# 201724
city: Debrecen
country: Hungary
facility: Debreceni Egyetem Kenezy Gyula Egyetemi Korhaz /ID# 201723
city: Kistarcsa
country: Hungary
facility: Pest Megyei Flor Ferenc Korhaz /ID# 206154
city: Szekesfehervar
country: Hungary
facility: Mentahaz Maganorvosi Kozpont /ID# 201895
city: Cork
country: Ireland
facility: Mercy University Hospital /ID# 206511
city: Be'er Sheva
country: Israel
facility: Soroka University Medical Center /ID# 169913
state: HaDarom
city: Tel Aviv-Yafo
country: Israel
facility: Tel Aviv Sourasky Medical Center /ID# 204877
state: Tel-Aviv
city: Be'Er Ya'Akov
country: Israel
facility: Assaf Harofeh Medical Center /ID# 204872
city: Jerusalem
country: Israel
facility: Hadassah Medical Center-Hebrew University /ID# 169928
city: Petakh Tikva
country: Israel
facility: Rabin Medical Center /ID# 202636
city: Rehovot
country: Israel
facility: Kaplan Medical Center /ID# 170276
city: Rome
country: Italy
facility: Policlinico Universitario Campus Bio-Medico /ID# 168183
state: Lazio
city: Rome
country: Italy
facility: Azienda Ospedaliera San Camillo Forlanini /ID# 168184
state: Lazio
city: Rozzano
country: Italy
facility: Istituto Clinico Humanitas /ID# 168185
state: Milano
city: Rome
country: Italy
facility: Fondazione PTV Policlinico Tor Vergata /ID# 168188
state: Roma
city: Rome
country: Italy
facility: Presidio Columbus-Fondazione Policlinico Universitario Agostino Gemelli IRCCS-Un /ID# 168182
state: Roma
city: Negrar
country: Italy
facility: IRCCS Ospedale Sacro Cuore Don Calabria /ID# 168186
state: Verona
city: Bologna
country: Italy
facility: IRCCS Azienda Ospedaliero-Universitaria di Bologna /ID# 168187
city: Catania
country: Italy
facility: A.O. Per L'Emergenza Cannizzaro /ID# 168190
city: Genova
country: Italy
facility: Policlinico San Martino/Univer /ID# 168191
city: Milano
country: Italy
facility: ASST Fatebenefratelli Sacco - Ospedale Fatebenefratelli e Oftalmico /ID# 168181
city: Milano
country: Italy
facility: ASST Grande Ospedale Metropolitano Niguarda /ID# 170849
city: Modena
country: Italy
facility: Azienda Ospedaliero-Universitaria di Modena /ID# 201897
city: Palermo
country: Italy
facility: A.O. Ospedali Riuniti Villa Sofia - Cervello /ID# 168189
city: Pisa
country: Italy
facility: Azienda Ospedaliero Universitaria Pisana-Stabilimento di Cisanello /ID# 202421
city: Nagakute-shi
country: Japan
facility: Aichi Medical University Hospital /ID# 165971
state: Aichi
city: Nagoya shi
country: Japan
facility: Nagoya City University Hospital /ID# 165970
state: Aichi
city: Nagoya-shi
country: Japan
facility: Nagoya University Hospital /ID# 165969
state: Aichi
city: Toyohashi-shi
country: Japan
facility: Toyohashi Municipal Hospital /ID# 200175
state: Aichi
city: Hirosaki-shi
country: Japan
facility: National Hospital Organization Hirosaki General Medical Center /ID# 165961
state: Aomori
city: Sakura-shi
country: Japan
facility: Toho University Sakura Medical Center /ID# 165963
state: Chiba
city: Chikushino-shi
country: Japan
facility: Fukuoka University Chikushi Hospital /ID# 214404
state: Fukuoka
city: Kurume-shi
country: Japan
facility: Kurume University Hospital /ID# 166012
state: Fukuoka
city: Takasaki-shi
country: Japan
facility: National Hospital Organization Takasaki General Medical Center /ID# 167127
state: Gunma
city: Fukuyama-shi
country: Japan
facility: NHO Fukuyama Medical Center /ID# 167131
state: Hiroshima
city: Hiroshima-shi
country: Japan
facility: Hiroshima University Hospital /ID# 166014
state: Hiroshima
city: Asahikawa-shi
country: Japan
facility: Asahikawa Medical University Hospital /ID# 167120
state: Hokkaido
city: Sapporo-shi
country: Japan
facility: Hokkaido P.W.F.A.C. Sapporo-Kosei General Hospital /ID# 165960
state: Hokkaido
city: Sapporo-shi
country: Japan
facility: Sapporo Medical University Hospital /ID# 167124
state: Hokkaido
city: Sapporo-shi
country: Japan
facility: Sapporo IBD Clinic /ID# 223561
state: Hokkaido
city: Kobe-shi
country: Japan
facility: Aoyama Clinic /ID# 166009
state: Hyogo
city: Nishinomiya-shi
country: Japan
facility: Hyogo College of Medicine College Hospital /Id# 165973
state: Hyogo
city: Kanazawa-shi
country: Japan
facility: Kanazawa University Hospital /ID# 169218
state: Ishikawa
city: Morioka-shi
country: Japan
facility: Iwate Medical University Uchimaru Medical Center /ID# 202464
state: Iwate
city: Kagoshima-shi
country: Japan
facility: Imamura General Hospital /ID# 227137
state: Kagoshima
city: Kagoshima-shi
country: Japan
facility: Idzuro Imamura Hospital /ID# 206654
state: Kagoshima
city: Kagoshima-shi
country: Japan
facility: Sameshima Hospital /ID# 206675
state: Kagoshima
city: Yokohama shi
country: Japan
facility: Yokohama City University Medical Center /ID# 167128
state: Kanagawa
city: Kyoto-shi
country: Japan
facility: Japanese Red Cross Kyoto Daiichi Hosital /ID# 165972
state: Kyoto
city: Kyoto-shi
country: Japan
facility: Kyoto University Hospital /ID# 169889
state: Kyoto
city: Yokkaichi-shi
country: Japan
facility: Yokkaichi Hazu Medical Center /ID# 167196
state: Mie
city: Sendai-shi
country: Japan
facility: Tohoku University Hospital /ID# 167122
state: Miyagi
city: Kashihara-shi
country: Japan
facility: Nara Medical University Hospital /ID# 169219
state: Nara
city: Yamatotakada-shi
country: Japan
facility: Kenseikai Dongo Hospital /ID# 208104
state: Nara
city: Niigata-shi
country: Japan
facility: Niigata University Medical & Dental Hospital /ID# 170045
state: Niigata
city: Oita-shi
country: Japan
facility: Ishida Clinic of IBD and Gastroenterology /ID# 167121
state: Oita
city: Kurashiki-shi
country: Japan
facility: Chikuba Hospital for Proctological and Gastrointestinal Diseases /ID# 166010
state: Okayama
city: Okayama-shi
country: Japan
facility: Okayama University Hospital /ID# 167356
state: Okayama
city: Osaka-shi
country: Japan
facility: Kinshukai Infusion Clinic /ID# 218872
state: Osaka
city: Osaka-shi
country: Japan
facility: Osaka Metropolitan University Hospital /ID# 166015
state: Osaka
city: Suita-shi
country: Japan
facility: Osaka University Hospital /ID# 169663
state: Osaka
city: Takatsuki-shi
country: Japan
facility: Osaka Medical and Pharmaceutical University Hospital /ID# 206326
state: Osaka
city: Saitama-shi
country: Japan
facility: Tokitokai Tokito clinic /ID# 165962
state: Saitama
city: Otsu-shi
country: Japan
facility: Shiga University of Medical Science Hospital /ID# 167129
state: Shiga
city: Hamamatsu-shi
country: Japan
facility: Hamamatsu University Hospital /ID# 224352
state: Shizuoka
city: Sunto-gun
country: Japan
facility: NHO Shizuoka Medical Center /ID# 167125
state: Shizuoka
city: Bunkyo-ku
country: Japan
facility: Tokyo Medical And Dental University Hospital /ID# 165965
state: Tokyo
city: Hachioji-shi
country: Japan
facility: Tokai University Hachioji Hospital /ID# 165967
state: Tokyo
city: Minato-ku
country: Japan
facility: The Jikei University Hospital /ID# 167130
state: Tokyo
city: Mitaka-shi
country: Japan
facility: Kyorin University Hospital /ID# 165966
state: Tokyo
city: Shinjuku-ku
country: Japan
facility: Tokyo Women's Medical University Hospital /ID# 205980
state: Tokyo
city: Toyama-shi
country: Japan
facility: Toyama Prefectural Central Hospital /ID# 217834
state: Toyama
city: Wakayama-shi
country: Japan
facility: Japanese Red Cross Wakayama Medical Center /ID# 200643
state: Wakayama
city: Wakayama-shi
country: Japan
facility: Wakayama Medical University Hospital /ID# 169482
state: Wakayama
city: Yamagata-shi
country: Japan
facility: Yamagata University Hospital /ID# 200157
state: Yamagata
city: Guri
country: Korea, Republic of
facility: Hayang University GuriHospital /ID# 167587
state: Gyeonggido
city: Seongnam si
country: Korea, Republic of
facility: CHA University Bundang Medical Center /ID# 167592
state: Gyeonggido
city: Seoul
country: Korea, Republic of
facility: Kangbuk Samsung Hospital /ID# 167586
state: Seoul Teugbyeolsi
city: Seoul
country: Korea, Republic of
facility: Yonsei University Health System Severance Hospital /ID# 167590
state: Seoul Teugbyeolsi
city: Busan
country: Korea, Republic of
facility: Inje University Haeundae Hospital /ID# 202630
city: Busan
country: Korea, Republic of
facility: Dong-A University Hospital /ID# 167591
city: Busan
country: Korea, Republic of
facility: Pusan National University Hospital /ID# 167589
city: Daegu
country: Korea, Republic of
facility: Kyungpook National University Hospital /ID# 207019
city: Seoul
country: Korea, Republic of
facility: Samsung Medical Center /ID# 167588
city: Seoul
country: Korea, Republic of
facility: Chung-Ang University Hostipal /ID# 207018
city: Riga
country: Latvia
facility: VCA Polyclinic Aura /ID# 169498
city: Riga
country: Latvia
facility: Pauls Stradins Clinical University Hospital /ID# 169519
city: Riga
country: Latvia
facility: Digestive Disease Center Gastro /ID# 169508
city: Kaunas
country: Lithuania
facility: Hospital of Lithuanian University of Health Sciences Kaunas Clinics /ID# 206936
city: Vilnius
country: Lithuania
facility: Vilnius University Hospital Santaros Klinikos /ID# 203286
city: Alor Setar
country: Malaysia
facility: Hospital Sultanah Bahiyah /ID# 202626
state: Kedah
city: Kuala Lumpur
country: Malaysia
facility: Universiti Kebangsaan Malaysia (UKM) Medical Centre /ID# 170773
state: Selangor
city: Kelantan
country: Malaysia
facility: Universiti Sains Malaysia /ID# 200102
city: Victoria de Durango
country: Mexico
facility: Instituto de Investigaciones Aplicadas a la Neurociencias A.C. /ID# 207579
state: Durango
city: Leon
country: Mexico
facility: Morales Vargas Centro de Investigacion S.C. /ID# 203494
state: Guanajuato
city: Guadalajara
country: Mexico
facility: Clinica de Investigacion en Reumatologia y Obesidad S.C. /ID# 207238
state: Jalisco
city: Nijmegen
country: Netherlands
facility: Radboud Universitair Medisch Centrum /ID# 166928
state: Gelderland
city: Heerlen
country: Netherlands
facility: Zuyderland Medisch Centrum /ID# 169700
state: Limburg
city: Amsterdam
country: Netherlands
facility: Onze Lieve Vrouwe Gasthuis /ID# 166929
city: Amsterdam
country: Netherlands
facility: Academisch Medisch Centrum /ID# 166927
city: Enschede
country: Netherlands
facility: Medisch Spectrum Twente /ID# 170298
city: Wroclaw
country: Poland
facility: Vistamed /ID# 208572
state: Dolnoslaskie
city: Krakow
country: Poland
facility: Malopolskie Centrum Kliniczne /ID# 202167
state: Malopolskie
city: Warsaw
country: Poland
facility: WIP Warsaw IBD Point Profesor Kierkus /ID# 224301
state: Mazowieckie
city: Warszawa
country: Poland
facility: Centrum Zdrowia MDM /ID# 200491
state: Mazowieckie
city: Warszawa
country: Poland
facility: Centrum Medyczne Reuma Park /ID# 200490
state: Mazowieckie
city: Guimaraes
country: Portugal
facility: Hospital da Senhora da Oliveira Guimaraes, EPE /ID# 170245
state: Braga
city: Lisbon
country: Portugal
facility: Hospital Egas Moniz /ID# 170253
state: Porto
city: Ponte de Lima
country: Portugal
facility: Unidade Local de Saúde do Alto Minho, EPE - Hospital Conde de Bertiandos /ID# 200607
state: Viana Do Castelo
city: Almada
country: Portugal
facility: Hospital Garcia de Orta, EPE /ID# 170241
city: Porto
country: Portugal
facility: Centro Hospitalar Universitario de Sao Joao, EPE /ID# 170248
city: San Juan
country: Puerto Rico
facility: Mindful Medical Research /ID# 203358
city: San Juan
country: Puerto Rico
facility: School of Medicine University of Puerto Rico-Medical Science Campus /ID# 166771
city: Sector 2
country: Romania
facility: Institutul Clinic Fundeni /ID# 167817
state: Bucuresti
city: Cluj-Napoca
country: Romania
facility: Clinica GASTRO MED SRL /ID# 206369
state: Cluj
city: Timișoara
country: Romania
facility: Cabinet Particular Policlinic Algomed /ID# 167818
city: Kaliningrad
country: Russian Federation
facility: Immanuel Kant Baltic Federal University /ID# 203811
state: Kaliningradskaya Oblast
city: Novosibirsk
country: Russian Federation
facility: LLC Medical Center /ID# 209236
state: Novosibirskaya Oblast
city: Perm
country: Russian Federation
facility: Perm Clinical Center of the Federal Medical and Biological Agency /ID# 202990
state: Permskiy Kray
city: Pyatigorsk
country: Russian Federation
facility: LLC Novaya Klinika /ID# 206616
state: Stavropol Skiy Kray
city: Stavropol
country: Russian Federation
facility: Professor Pasechnikov Gastroenterology and Pankreatology clinic /ID# 202997
state: Stavropol Skiy Kray
city: Kazan
country: Russian Federation
facility: Kazan State Medical University /ID# 169638
state: Tatarstan, Respublika
city: Moscow
country: Russian Federation
facility: Olla-Med Clinic /ID# 208720
city: Murmansk
country: Russian Federation
facility: P.A. Bayandin Murmansk Regiona /ID# 169639
city: Petrozavodsk
country: Russian Federation
facility: Republican hospital named after V.A. Baranov /ID# 206488
city: Pushkin
country: Russian Federation
facility: Euromedservice /ID# 206610
city: Saint Petersburg
country: Russian Federation
facility: X7 Clinical Research Center /ID# 216350
city: St. Petersburg
country: Russian Federation
facility: City Clinical Hospital No. 31 /ID# 208868
city: Belgrade
country: Serbia
facility: Clinical Hosp Center Zvezdara /ID# 168214
state: Beograd
city: Belgrade
country: Serbia
facility: Military Medical Academy /ID# 168783
state: Beograd
city: Belgrade
country: Serbia
facility: University Clinical Center Serbia /ID# 168215
state: Beograd
city: Belgrade
country: Serbia
facility: Clin Hosp Ctr Bezanijska Kosa /ID# 168750
state: Beograd
city: Kragujevac
country: Serbia
facility: University Clinical Center Kragujevac /ID# 205859
state: Sumadijski Okrug
city: Novi Sad
country: Serbia
facility: Clinical Center Vojvodina /ID# 168213
state: Vojvodina
city: Singapore
country: Singapore
facility: KL Ling Gastroenterology and Liver Clinic /ID# 217962
city: Singapore
country: Singapore
facility: Gleneagles Medical Centre /ID# 206531
city: Singapore
country: Singapore
facility: Tan Tock Seng Hospital /ID# 203160
city: Banska Bystrica
country: Slovakia
facility: Fakultna nemocnica s poliklinikou F.D. Roosevelta Banska Bystrica /ID# 169958
city: Nitra
country: Slovakia
facility: KM Management, spol. s.r.o. /ID# 170201
city: Ljubljana
country: Slovenia
facility: Univ Medical Ctr Ljubljana /ID# 217795
city: Bloemfontein
country: South Africa
facility: Farmovs (Pty) Ltd /Id# 207535
state: Free State
city: Johannesburg
country: South Africa
facility: Lenasia Clinical Trial Centre /ID# 205145
state: Gauteng
city: Johannesburg
country: South Africa
facility: Wits Clinical Research Site /ID# 170852
state: Gauteng
city: Cape Town
country: South Africa
facility: Allergy & Immunology (AIU) /ID# 171431
state: Western Cape
city: Cape Town
country: South Africa
facility: Dr JP Wright /ID# 170887
state: Western Cape
city: Cape Town
country: South Africa
facility: Private Practice Dr MN Rajabally /ID# 169853
state: Western Cape
city: Palma de Mallorca
country: Spain
facility: Hospital Universitari Son Espases /ID# 201998
state: Illes Balears
city: Pamplona
country: Spain
facility: Hospital Universitario de Navarra /ID# 202355
state: Navarra
city: A Coruna
country: Spain
facility: Hospital Universitario A Coruna - CHUAC /ID# 203910
city: Barcelona
country: Spain
facility: Hospital Clinic de Barcelona /ID# 201990
city: Girona
country: Spain
facility: Hospital Universitario de Girona Doctor Josep Trueta /ID# 202645
city: Huelva
country: Spain
facility: Hospital Juan Ramon Jimenez /ID# 201995
city: Madrid
country: Spain
facility: Hospital Universitario La Paz /ID# 201994
city: Salamanca
country: Spain
facility: Hospital Universitario de Salamanca /ID# 206358
city: Sevilla
country: Spain
facility: Hospital Universitario Virgen Macarena /ID# 201993
city: Valencia
country: Spain
facility: Hospital Clinico Universitario de Valencia /ID# 209657
city: Valencia
country: Spain
facility: Hospital Universitario y Politecnico La Fe /ID# 201992
city: Halmstad
country: Sweden
facility: Hallands Hospital Halmstad /ID# 170828
state: Hallands Lan
city: Solna
country: Sweden
facility: Karolinska University Hospital Solna /ID# 224488
state: Stockholms Lan
city: Alingsas
country: Sweden
facility: Alingsas lasarett /ID# 170826
state: Vastra Gotalands Lan
city: Boras
country: Sweden
facility: Sodra Alvsborgs sjukhus /ID# 203077
state: Vastra Gotalands Lan
city: Gothenburg
country: Sweden
facility: Sahlgrenska University Hospital /ID# 169171
state: Vastra Gotalands Lan
city: Zürich
country: Switzerland
facility: Universitätsspital Zürich /ID# 170998
state: Zuerich
city: Bern
country: Switzerland
facility: Inselspital, Universitätsspital Bern /ID# 170997
city: Taichung City
country: Taiwan
facility: China Medical University Hospital /ID# 169791
city: Taichung
country: Taiwan
facility: Taichung Veterans General Hospital /ID# 169790
city: Taipei City
country: Taiwan
facility: National Taiwan University Hospital /ID# 169792
city: Kadikoy
country: Turkey
facility: Acibadem Kozyatagi Hospital /ID# 209406
state: Istanbul
city: Melikgazi
country: Turkey
facility: Erciyes University Medical Fac /ID# 171331
state: Kayseri
city: Ankara
country: Turkey
facility: Ankara Univ Medical Faculty /ID# 206409
city: Battalgazi/malatya
country: Turkey
facility: Inonu Universitesi Turgut Ozal /ID# 201268
city: Hatay
country: Turkey
facility: Mustafa Kemal University Medic /ID# 171336
city: Istanbul
country: Turkey
facility: Istanbul University Istanbul Medical Faculty /ID# 171364
city: Istanbul
country: Turkey
facility: Marmara Universitesi Pendik Egitim ve Arastirma Hastanesi /ID# 171332
city: Mersin
country: Turkey
facility: Mersin University Medical /ID# 171338
city: Sisli
country: Turkey
facility: Sisli Etfal Train & Res Hosp /ID# 171334
city: Yenimahalle
country: Turkey
facility: Gazi Universitesi Tip Fakultes /ID# 217444
city: Kyiv
country: Ukraine
facility: Medical Centre of "Ukrainian German Antiulcer Gastroenterology Centre BYK-KYIV" /ID# 203738
state: Kyivska Oblast
city: Kharkiv
country: Ukraine
facility: Kharkiv City Clinical Hospital No.2 n.a. Prof. O.O. Shalimov /ID# 167907
city: Kyiv
country: Ukraine
facility: Kyiv Municipal Clinical Hospital #18 /ID# 207889
city: Kyiv
country: Ukraine
facility: MNI KRC Kyiv Regional Clinical Hospital /ID# 202454
city: Lviv
country: Ukraine
facility: Lviv Railway Clinical Hospital of branch Healthcare Centers of Public Joint Stoc /ID# 167908
city: Vinnytsia
country: Ukraine
facility: CNE Vinnytsya Regional Clinical Hospital named after N.I.Pirogov /ID# 222110
city: Belfast
country: United Kingdom
facility: South Eastern Health and Social Care Trust /ID# 205323
state: Antrim
city: Warrington
country: United Kingdom
facility: Warrington and Halton Hospitals NHS Foundation Trust /ID# 171383
state: Cheshire West And Chester
city: Warrington
country: United Kingdom
facility: Warrington and Halton Hospitals NHS Foundation Trust /ID# 209086
state: Cheshire West And Chester
city: Bath
country: United Kingdom
facility: Royal United Hospitals Bath /ID# 169074
city: Birmingham
country: United Kingdom
facility: University Hospitals Birmingham NHS Foundation Trust /ID# 169070
city: Dudley
country: United Kingdom
facility: The Dudley Group NHS Foundation Trust /ID# 169069
city: London
country: United Kingdom
facility: King's College Hospital NHS Foundation Trust /ID# 169072
city: Newcastle Upon Tyne
country: United Kingdom
facility: The Newcastle Upon Tyne Hospitals NHS Foundation Trust /ID# 169075
city: Stockport
country: United Kingdom
facility: Stockport NHS foundation trust /ID# 208719
city: Taunton
country: United Kingdom
facility: Taunton and Somerset NHS Foundation Trust /ID# 209665
city: Tooting
country: United Kingdom
facility: St George's University Hospitals NHS Foundation Trust /ID# 205552
city: Wolverhampton
country: United Kingdom
facility: The Royal Wolverhampton NHS Trust /ID# 171382
Study officials:
affiliation: AbbVie
name: ABBVIE INC.
role: STUDY_DIRECTOR
References: