Clinical trial NCT06782828: Accuracy of FNAC in Diagnosis of Thyroid Nodules
Official title: Accuracy of FNAC in Diagnosis of Thyroid Nodules
Study type: OBSERVATIONAL
Overall status: NOT_YET_RECRUITING
Conditions: Thyroid Nodule
Lead sponsor: Assiut University
Sponsor class: OTHER
First posted: 2025-01-20
Enrollment: 100
Sex: ALL
Minimum age (years): 10
Maximum age (years): 80
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: All patients presented to General Surgery Department with either solitary or multiple suspicious thyroid nodules during time of research.

Brief summary: Detection of degree of accuracy of FNAC in diagnosis of thyroid nodules

Detailed description: Accuracy in diagnosis in any case is required, and this is beneficial to the patient and the physician, and with the development that currently exists and the trend to use less invasive techniques, accuracy of FNAC should be studied well.1.Thyroid nodules are common and the principal method of diagnosis is fine-needle aspiration cytology (FNAC).2. Can investigators depend on FNAC alone in diagnosis of thyroid nodule in the future?!3. In this study, investigators will compare the results of (FNAC) versus (Biopsy) in diagnosis of thyroid nodule in AUH , to detect the degree of accuracy of FNAC.4. FNAC is a simple, safe, cost-effective and accurate diagnostic tool for the initial screening of patients with thyroid nodules.5. Background Routine application of fine needle aspiration cytology (FNAC) has decreased unnecessary referral of thyroid nodules for surgical treatment and has also increased the cancer rates found in surgery materials. Success of thyroid FNAC depends on skilled aspiration, skilled cytological interpretation and rational analysis of cytological and clinical data. The aim of this study was to determine the diagnostic accuracy rates of thyroid FNAC results obtained in our hospital.6. The FNAC is a sensitive, specific, and accurate initial diagnostic test for the preoperative evaluation of patients with thyroid swellings in our setting as well. The correlation of cytological and histopathological diagnoses is an important quality assurance method, as it allows cytopathologists to calculate their false-positive and false negative results.7

Eligibility criteria: Inclusion Criteria:

1. thyroid disease
2. multinodular
3. single nodule
4. TIRAD 3 or more by US
5. thyroid disease underwent FNAC then surgery
6. all age groups
7. patient fit for surgery

Exclusion Criteria:

1. patients with comorbidities.
2. patients unfit for surgery
3. patients who refused surgery.
4. Patient with no diagnostic FNAC.

Primary outcomes:
measure: Incidence of true positive results of FNAC after thyroidectomy
timeFrame: 12 days
measure: Percentage of malignant thyroid nodules not observed by FNAC
timeFrame: 12 days
measure: Incidence of false negative results by FNAC
timeFrame: 12 days
measure: Percentage of total number of true results of FNAC to the total number of cases
timeFrame: 12 days
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
References:
citation: Poller DN, Stelow EB, Yiangou C. Thyroid FNAC cytology: can we do it better? Cytopathology. 2008 Feb;19(1):4-10. doi: 10.1111/j.1365-2303.2007.00492.x. Epub 2007 Oct 3.
citation: Bhise SV, Shaikh A, Hippargekar PM, Kothule S. A Prospective Study of Ultrasonographic and FNAC Correlation of Thyroid Swellings with Histopathology. Indian J Otolaryngol Head Neck Surg. 2022 Oct;74(Suppl 2):1942-1948. doi: 10.1007/s12070-020-01922-w. Epub 2020 Jun 24.
citation: Momin MA, Bhuiyan FU, Chakraborty S, Kar NK. FNAC and Its Utility in Solitary Thyroid Nodule and Its Correlation with Histopathological Examination. Mymensingh Med J. 2019 Apr;28(2):356-363.