Clinical trial NCT07023705: MLPR As A Diagnostic Marker For Acute Pulmonary Embolism
Official title: Monocyte To Large Platelet Ratio As A Diagnostic Marker For Acute Pulmonary Embolism
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Pulmonary Embolism (Diagnosis)
Diagnosis
Lead sponsor: Ain Shams University
Sponsor class: OTHER
First posted: 2025-06-17
Enrollment: 37
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients presenting to the emergency department with signs and symptoms of pulmonary embolism who underwent CT pulmonary angiography for diagnosis.

Brief summary: A retrospective study to assess the utility of hematological marker (monocyte to large platelet ratio) to diagnose patients with pulmonary embolism

Detailed description: We conducted a retrospective review of emergency department records of patients who presented with signs and symptoms suggestive of pulmonary embolism (PE) and underwent CT pulmonary angiography (CTPA) for diagnosis. Hematological laboratory findings obtained prior to any treatment were collected and compared between two groups based on CTPA results: those with confirmed PE (CT positive) and those without PE (CT negative).

Eligibility criteria: Inclusion Criteria:

* Only patients with the results of full blood count and white blood cell differentiation, measured before the treatment of suspected PE.
* Patients underwent CT pulmonary angiography to confirm or exclude pulmonary embolism diagnosis.

Exclusion Criteria:

* Patient with his¬tory of any myeloproliferative disorder, myelo¬fibrosis, Glanzmann thrombasthenia, May-Heg¬glin anomaly, Bernard-Soulier syndrome, suspicion of disseminated intravascular coagulation.
* Patient receiving any anticoagulant drug at a therapeutic dose.
* Patient with blood transfusion in the last 2 months.
* Patients with acute coronary syndrome, pulmonary edema.
* Patient on immunosuppressive drugs , Oral contraceptive pills .
* Patients with severe renal or hepatic disease.
* Patients with Stroke.
* Patients with malignancy.

Primary outcomes:
measure: Monocyte-to-Large Platelet Ratio (MLPR)
timeFrame: At emergency department admission (baseline lab measurement) before any treatment.
Secondary outcomes:
measure: Mean platelet volume (MPV)
timeFrame: At emergency department admission (baseline lab measurement) before any treatment.
measure: Neutrophil to Lymphocyte Ratio (NLR)
timeFrame: At emergency department admission (baseline lab measurement) before any treatment.
measure: D-Dimer
timeFrame: At emergency department admission (baseline lab measurement) before any treatment.
measure: Platelet Distribution Width (PDW)
timeFrame: At emergency department admission (baseline lab measurement) before any treatment.
measure: Platelet To Lymphocyte (PLR)
timeFrame: At emergency department admission (baseline lab measurement) before any treatment.
Other outcomes:
Locations:
city: Cairo
country: Egypt
facility: Ain Shams University
Study officials:
affiliation: Ain Shams University
name: Reem H Elkabarity, Professor
role: STUDY_CHAIR
affiliation: Ain Shams University
name: Hadil M Abdelhamid, Professor
role: STUDY_DIRECTOR
affiliation: Ain Shams University
name: Azza Lotfy, Professor
role: STUDY_DIRECTOR
affiliation: Ain Shams University
name: Mohamed k Awad, Lecturer
role: PRINCIPAL_INVESTIGATOR
References:
citation: Granger V, Faille D, Marani V, Noel B, Gallais Y, Szely N, Flament H, Pallardy M, Chollet-Martin S, de Chaisemartin L. Human blood monocytes are able to form extracellular traps. J Leukoc Biol. 2017 Sep;102(3):775-781. doi: 10.1189/jlb.3MA0916-411R. Epub 2017 May 2.
citation: Moharamzadeh P, Rahmani F, Foroughifar S, Shahsavarinia K. Reliability of Platelet Indices for Diagnosing Pulmonary Embolism; a Brief Report. Adv J Emerg Med. 2019 Apr 28;3(3):e27. doi: 10.22114/ajem.v0i0.137. eCollection 2019 Summer.
citation: Talay F, Ocak T, Alcelik A, Erkuran K, Akkaya A, Duran A, Demirhan A, Kar Kurt O, Asuk Z. A new diagnostic marker for acute pulmonary embolism in emergency department: mean platelet volume. Afr Health Sci. 2014 Mar;14(1):94-9. doi: 10.4314/ahs.v14i1.15.
citation: Bialas AJ, Kornicki K, Ciebiada M, Antczak A, Sitarek P, Milkowska-Dymanowska J, Piotrowski WJ, Gorski P. Monocyte to large platelet ratio as a diagnostic tool for pulmonary embolism in patients with acute exacerbation of chronic obstructive pulmonary disease. Pol Arch Intern Med. 2018 Jan 31;128(1):15-23. doi: 10.20452/pamw.4141. Epub 2017 Nov 7.