louisbrulenaudet/clinical-trials huggingface dataset:
Clinical trial NCT05601609: Are Sporadic Colorectal Cancers in Young Distinct From Elderly?
Official title: Are Sporadic Colorectal Cancers in Young Distinct From Elderly?
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Colorectal Neoplasms
Keywords: young colorectal cancer patients
elderly colorectal cancer patients
sporadic colorectal cancer
Lead sponsor: Seoul National University Bundang Hospital
Sponsor class: OTHER
Collaborators: name: Seoul National University Hospital
First posted: 2022-11-01
Enrollment: 1599
Sex: ALL
Minimum age (years): 18
Maximum age (years): 100
Standard ages: ADULT
OLDER_ADULT
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Three tertiary referral hospitals between January 2010 to December 2017

Brief summary: In this study, the investigators compared and evaluated the clinicopathological and oncological characteristics of sporadic colorectal cancer (CRC) in young adults without genetic mutations associated with hereditary CRC syndrome and sporadic CRC in elderly individuals.

Detailed description: The ambiguity in the findings among several previous studies might be because of the difference in the age of the study population, yCRC and eCRC. The family history of CRC and cancer due to Crohn's disease or ulcerative colitis were also not excluded in such previous studies. Most importantly, those studies did not rule out the risk of hereditary cancer through the genetic testing in yCRC. Since hereditary CRC accounts for approximately 34% of those under the age of 35 years, it is necessary to exclude it to accurately compare the clinicopathological characteristics of sporadic cancer developed in yCRC and eCRC.

Eligibility criteria: Inclusion Criteria:

* Histologically confirmed cases of adenocarcinoma in the colon and rectum
* The age at the time of diagnosis should be ≤ 40 years (for yCRC) or ≥ 70 years (for eCRC)
* Genetic testing confirmation of non-hereditary cancer.

Exclusion Criteria:

* Inflammatory bowel disease
* A family history of CRC
* A history of other cancers
* Underwent any emergency operation or palliative surgery
* The Amsterdam criteria with mutations in genes associated with APC, MLH1, MSH2, MSH6

Primary outcomes:
measure: Overall survival outcome in young colorectal cancer (yCRC) and elderly colorectal cancer (eCRC)
timeFrame: The OS was defined as the time period from the date of surgery to the date of death or last follow-up up to 3 years
Secondary outcomes:
measure: Cancer-specific survival outcome in young colorectal cancer (yCRC) and elderly colorectal cancer (eCRC)
timeFrame: CSS was defined as the time period from the date of surgery to the date of death from CRC up to 3years
Other outcomes:
Locations:
city: Seongnam-si
country: Korea, Republic of
facility: Seoul National University Bundang Hospital
state: Gyeonggi-do
Study officials:
affiliation: Seoul National University Bundang Hospital
name: Duck-Woo Kim, MD PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01249209: Outpatient Treatment of Patients With Morbid Obesity - a Two-year Follow up
Official title: Qualitative Retrospective Study Where the Intervention Consisted of Group Therapy and Individual Interviews Over a Two-year Period
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Morbid Obesity
Keywords: obesity
adults
lifestyle intervention
effect after two years treatment for lifestyle change - morbid obesity adults
Lead sponsor: Sykehuset Innlandet HF
Sponsor class: OTHER
First posted: 2010-11-29
Enrollment: 69
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This study is a pilot project to investigate any effect on these markers in conjunction with lifestyle changes / conservative treatment. Useful and significant information in this pilot project is intended to be used as background for further research on this issue in connection with a doctorate.

What is the effect of two years of outpatient treatment for lifestyle change for weight markers, waist, BMI, HbA1c, HDL and LDL cholesterol, triglycerides and uric acid in adults with morbid obesity?


Eligibility criteria: Inclusion Criteria:

* Adults from 18 - 60 years, both sex

Primary outcomes:
Secondary outcomes:
Other outcomes:
Locations:
city: Kongsvinger
country: Norway
facility: Sykehuset Innlandet Kongsvinger
Study officials:
References:
Clinical trial NCT04943393: Remote Neurocognitive and Psychological Assessment in PKU
Official title: Remote Assessment of Working Memory and Anxiety in Individuals With Early-Treated Phenylketonuria (PKU)
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Phenylketonurias
Lead sponsor: University of Missouri-Columbia
Sponsor class: OTHER
First posted: 2021-06-29
Enrollment: 84
Sex: ALL
Minimum age (years): 18
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Individuals age 18-40 years old with and without PKU

Brief summary: PKU is a rare autosomal recessive condition associated with disruption in dopamine synthesis. Although early diagnosis and treatment prevent the severe impairments associated with untreated PKU, individuals with early-treated PKU (ETPKU) nonetheless experience significant sequelae, including impaired working memory and increased risk for anxiety problems. Past research with other clinical populations (e.g., generalized anxiety disorder) suggests that the two phenomena may be linked, with increased anxiety contributing to poorer WM performance. Currently we propose to initiate an exciting new line of research examining the potential relationship between anxiety and WM in ETPKU. The proposed study will also apply remote neuropsychological performance-based assessment to the study of ETPKU and thus overcoming the geographical limitations/challenges associated with recruitment of participants with this rare disease.


Eligibility criteria: Inclusion Criteria:

* Participants with PKU will be included if they were diagnosed as newborns and immediately started on treatment.

Exclusion Criteria:

* Individuals with a history of neurologic compromise or major medical disorder unrelated to PKU (e.g., closed head injury, diabetes, multiple sclerosis) will be excluded. In addition, individuals with PKU will be excluded if they are on a medication called Peg-Valiant/ PEG-PAL/ Pegvaliase/Palynziq.

Primary outcomes:
measure: Working Memory performance
timeFrame: 2.5-3 hrs total over approx 1-3 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Atlanta
country: United States
facility: Emory University
state: Georgia
city: Columbia
country: United States
facility: University of Missouri
state: Missouri
Study officials:
affiliation: University of Missouri-Columbia
name: Shawn Christ, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT02842593: Vascular Responses to High vs Low Repetition Resistance Exercise Training in Young Men
Official title: Vascular Responses to High vs Low Repetition Resistance Exercise Training in Young Men
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Weight-Lifting Exercise Program
Lead sponsor: McMaster University
Sponsor class: OTHER
First posted: 2016-07-25
Enrollment: 60
Sex: MALE
Minimum age (years): 18
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: BASIC_SCIENCE

Brief summary: This study evaluates the effects of two types of resistance exercise training (higher-repetition, lower load vs lower-repetition, higher load vs control) on regional and local measures of arterial stiffness in trained young men.


Eligibility criteria: Inclusion Criteria:

* Male
* Aged 18-30 years old
* Non-obese (Body mass index less than 30 kg/m2)
* Non-smoker
* Healthy based on questionnaire responses
* Resistance trained (Resistance training \> 2 times per week for 2 years, minimum 1 lower body exercise session per week)

Exclusion Criteria:

* Allergies to milk proteins (whey or casein)
* Any acute or chronic illness, cardiac, pulmonary, liver, or kidney abnormalities, uncontrolled hypertension, insulin- or non-insulin dependent diabetes or other metabolic disorders-all ascertained through medical history screening questionnaires
* Arthritic conditions
* Individuals who consume any analgesic or anti-inflammatory drug(s), prescription or non- prescription, chronically will be excluded
* A history of neuromuscular problems
* Individuals on any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications).

Primary outcomes:
measure: Carotid-femoral pulse wave velocity
timeFrame: 12 weeks post exercise training
Secondary outcomes:
measure: Common carotid artery distensibility
timeFrame: 12 weeks post exercise training
measure: Left ventricular mass
timeFrame: 12 weeks post exercise training
Other outcomes:
Locations:
city: Hamilton
country: Canada
facility: McMaster University
state: Ontario
Study officials:
affiliation: McMaster University
name: Stuart M Phillips, PhD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT03135093: Upper Limb Function and Visuospatial Exploration After Stroke
Official title: Assessing Pathological Synergies of Upper Limb Function and the Relationship to Visuospatial Exploration After Stroke
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Stroke
Keywords: synergies
upper limb
vision
Lead sponsor: University of Zurich
Sponsor class: OTHER
First posted: 2017-05-01
Enrollment: 35
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: OTHER
Time perspective: CROSS_SECTIONAL
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Stroke subjects

Brief summary: This project is a cross-sectional, observational mono-center study with prospective data collecting.

This study aims to further explore quality of upper limb movement in relation to characteristics of visuospatial exploration in stroke subjects and healthy subjects by a applying comprehensive measurements of clinical scales and kinematic data in capacity- and performance-based activities. The results will contribute to assessing and monitoring quality of upper limb movements and visuospatial attention and their relationship.


Eligibility criteria: Inclusion Criteria:

* Subjects of 18 years and older with chronic ischemic stroke (\> 6 month) restricted to one hemisphere (confirmed by CT/MRI)
* With impairments in upper limb function and at least partial ability to lift the arm against gravity, flex and extend the fingers
* Without relevant pre-existing limitations in arm and hand function (orthopaedic, muscular, neurologic)
* Written informed consent after participants's information

Exclusion Criteria:

* Increased muscle tone in the upper limb with limited rang of motion
* Severe sensory deficits in the upper limb
* Clinically significant concomitant disease (affecting the upper limb or impaired vision, e.g. due to glaucoma etc.)
* Contraindications on ethical grounds (vulnerable persons)
* Known or suspected non-compliance, drug or alcohol abuse
* Severe communication or cognitive deficits, that cause inability to follow the procedures

Primary outcomes:
measure: Upper limb movement quality
timeFrame: One day
measure: Visuospatial exploration
timeFrame: One day
Secondary outcomes:
Other outcomes:
Locations:
city: Vitznau
country: Switzerland
facility: cereneo Schweiz AG
state: Luzern
Study officials:
References:
citation: Schwarz A, Bhagubai MMC, Nies SHG, Held JPO, Veltink PH, Buurke JH, Luft AR. Characterization of stroke-related upper limb motor impairments across various upper limb activities by use of kinematic core set measures. J Neuroeng Rehabil. 2022 Jan 12;19(1):2. doi: 10.1186/s12984-021-00979-0.
citation: Schwarz A, Veerbeek JM, Held JPO, Buurke JH, Luft AR. Measures of Interjoint Coordination Post-stroke Across Different Upper Limb Movement Tasks. Front Bioeng Biotechnol. 2021 Jan 28;8:620805. doi: 10.3389/fbioe.2020.620805. eCollection 2020.
Clinical trial NCT02810093: Big Data and Text-mining Technologies Applied for Breast Cancer Medical Data Analysis
Official title: SENOMETRY : Big Data and Text-mining Technologies Applied for Breast Cancer Medical Data Analysis
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Breast Cancer
Keywords: Breast cancer
Text mining
Big Data
Machine Learning
Lead sponsor: University Hospital, Strasbourg, France
Sponsor class: OTHER
Collaborators: name: Quantmetry
First posted: 2016-06-22
Enrollment: 10000
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients (men and women) suffering from an in situ or invasive cancer treated at Hôpitaux Universitaires de Strasbourg between years 2000 and 2016.

Brief summary: Primary purpose :

To develop a method to automatically extract and structure the information included in numerous medical records from breast cancer patients.

Secondary purpose :

With this procedure we can analyze the content of ten thousand anonymized textual medical records.

This information should enable us to explore many subjects, such as:

* The impact of certain therapeutic procedures
* The characteristics of sub-groups of patients
* Pregnancy associated breast cancers
* Risk factors


Eligibility criteria: Inclusion Criteria:

* Majority (age \> 18)
* Malignant breast tumors
* signed informed consent

Exclusion Criteria:

* Benign breast pathology
* Patients not initially treated at the Hôpitaux Universitaires de Strasbourg

Primary outcomes:
measure: Validate the reliability of a computer-based, automatic information retrieval method specific to medical records from breast cancer multidisciplinary meetings
timeFrame: 6 months
Secondary outcomes:
measure: Breast cancer recurrence rate after some therapeutic procedures
timeFrame: 6 months
Other outcomes:
Locations:
city: Strasbourg
country: France
facility: University Strasbourg Hospital
Study officials:
affiliation: Strasbourg's University Hospitals
name: Carole Mathelin, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00249093: Effects of Supplementary Oxygen on Dyspnoea and Exercise Tolerance in COPD Patients Given LTOT
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: COPD
Lead sponsor: LHL Helse
Sponsor class: OTHER
Collaborators: name: The norwegian association for heart and lung patients
First posted: 2005-11-07
Enrollment: 20
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: DIAGNOSTIC

Brief summary: The aim of the study is to evaluate effects of supplementary oxygen during exercise on dyspnoea and exercise tolerance in COPD-patients given long-time oxygen treatment


Eligibility criteria: Inclusion Criteria:

* COPD patients (male/female)given long-term oxygen treatment
* Able to perform two separate walking tests

Exclusion Criteria:

* Severe heart failure

Primary outcomes:
measure: dyspnea
measure: exercise tolerance
Secondary outcomes:
Other outcomes:
Locations:
city: Hakadal
country: Norway
facility: Glittreklinikken
Study officials:
affiliation: LHL Helse
name: Morten S Ryg, dr philos
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT01690793: Measurement of Natriuretic Hormone Peptides in Exacerbation of Asthma
Official title: Measurement of Natriuretic Hormone Peptides in Exacerbation of Asthma
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: ASTHMA
Keywords: ASTHMA
ACUTE EXACERBATION OF ASTHMA
Lead sponsor: University of South Florida
Sponsor class: OTHER
First posted: 2012-09-24
Enrollment: 30
Sex: ALL
Minimum age (years): 18
Maximum age (years): 85
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Sampling method: PROBABILITY_SAMPLE
Study population: The Asthma Control Test score of less than 18.

Asthma control test consists of five questions, scored 1-5 each.

Brief summary: The investigators hypothesize that there is a statistically significant decrease of Natriuretic Hormone Peptides (NHPs) in subjects with asthma exacerbation compared to levels following treatment of an exacerbation of asthma.

Detailed description: Overall Study Design

1. Measurement of Natriuretic Hormone Peptides in individuals suffering from exacerbation of asthma.
2. Measurement of Natriuretic Hormone Peptides 5-7 days after initiation of treatment of exacerbation of asthma.
3. Measurement of Natriuretic Hormone Peptides 10-14 days after initiation of treatment of exacerbation of asthma.

3 comparisons of Natriuretic Hormone Peptides levels will be made:

1. Exacerbation compared to 5-7 days after initiation of treatment
2. Exacerbation compared to 10-14 days after initiation of treatment
3. 5-7 days after initiation of treatment compared to 10-14 days after initiation of treatment.

Samples of blood will be secured in the Division of Allergy/Immunology at the University of South Florida, Joy McCann Culverhouse Airways Disease Center. All samples will be appropriately coded to maintain confidentiality. Blood specimens will be held at minus 20 degrees Celsius.

Eligibility criteria: Inclusion Criteria:

* Both genders, age 18-85.
* Females who are pregnant or lactating are not eligible.
* Read and comprehend English.
* Ability to give informed consent.
* Seen in the outpatient setting at one of the clinic.
* The subject must have a history of physician diagnosed asthma for at least 1 year and must have an exacerbation of asthma for entry into the study.

Primary outcomes:
measure: The measurement of NHPs after treatment of an exacerbation of asthma
timeFrame: 14 days
Secondary outcomes:
Other outcomes:
Locations:
city: Tampa
country: United States
facility: Usf Asthma Allergy and Immunology Cru
state: Florida
Study officials:
References:
Clinical trial NCT00386893: Somatosensory Processing in Depression
Official title: Influence of Escitalopram on Somatosensory Processing in Patients With Major Depression
Study type: INTERVENTIONAL
Overall status: WITHDRAWN
Phase: PHASE4
Conditions: Depression
Lead sponsor: Ludwig-Maximilians - University of Munich
Sponsor class: OTHER
Collaborators: name: H. Lundbeck A/S
First posted: 2006-10-12
Enrollment: 0
Sex: ALL
Minimum age (years): 18
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Aim of this study is to investigate neuronal differences (EEG/evoked potentials; functional MRI) between patients with major depression and healthy controls concerning brain activity after acute pain as well as changes of pain related brain activity during treatment with escitalopram.


Eligibility criteria: Inclusion Criteria:

* Psychiatric in or outpatients with acute depressive episode
* Indication for pharmacological treatment

Exclusion Criteria:

* Acute suicidal tendency
* Neurological or severe somatic disorders
* Women during pregnancy or lactation

Primary outcomes:
measure: changes in evoked potentials/functional MRI from baseline to week 4
timeFrame: two assessments, at baseline and week 4
Secondary outcomes:
Other outcomes:
Locations:
city: Munich
country: Germany
facility: Department of Psychiatry and Clin. Radiology, Ludwig-Maximilian-University
state: Bavaria
Study officials:
affiliation: Department of Psychiatry, Ludwig-Maximilians-University
name: Ulrich Hegerl, MD
role: PRINCIPAL_INVESTIGATOR
affiliation: Department of Psychiatry, Ludwig-Maximilians-University
name: Oliver Pogarell, MD
role: PRINCIPAL_INVESTIGATOR
References:
Clinical trial NCT00871793: Effect of Occupational Therapy on the Function and Mobility of Elbow Fractures
Official title: Effect of Occupational Therapy on the Function and Mobility in Supracondylar Humerus Fractures: A Randomized Controlled Trial
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Supracondylar Humerus Fracture
Lead sponsor: Seattle Children's Hospital
Sponsor class: OTHER
First posted: 2009-03-30
Enrollment: 61
Sex: ALL
Minimum age (years): 5
Maximum age (years): 12
Standard ages: CHILD
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Primary purpose: TREATMENT

Brief summary: Supracondylar humerus fracture are common upper extremity injuries in children accounting for over 400 fractures per year and approximately 25% of all fractures treated at Seattle Children's Emergency Department. Most of these fractures are treated with splints and casts though more than one-third undergo surgical fixation followed by casting. Healing is usually complete after 3-4 weeks, when casts (and pins, if fixed operatively) are removed and motion begun. Though stiffness is often a problem after immobilization of adult elbow fractures, stiffness after pediatric elbow fractures is regarded as typically transient. This study addresses the question "Does early motion of the arm with physiotherapy promote the return of function and motion in patients with supracondylar humerus fractures?" The investigators will conduct a prospective randomized trial to determine the effect of six occupational therapy visits over a five week period of time on elbow function and mobility after supracondylar humerus fracture. The investigators will measure motion of the elbow and administer the child and parental Activity Scale for Kids performance versions (ASKp) assessment tool to answer this question.


Eligibility criteria: Inclusion Criteria:

* Have a supracondylar fracture which is isolated, non - comminuted, and less than one week old.
* Will be treated with either casting or surgery.
* Lack head injuries or other fractures.
* Are not cognitively impaired or critically ill.
* Are 5 - 12 years old
* Speak English or Spanish

Exclusion Criteria:

* Requires open reduction to align
* Comminuted or t - intercondylar fracture
* Other fractures on the same limb
* Head injury
* Cognitive impairment
* Critically ill
* Mental disorders
* Fracture occurred more than one week prior to visit.

Primary outcomes:
measure: Activity Scale for Kids performance version (ASKp)
timeFrame: week 1, week 6, week 12, week 24
Secondary outcomes:
Other outcomes:
Locations:
city: Seattle
country: United States
facility: Seattle Children's Hospital
state: Washington
Study officials:
affiliation: University of Washington - Seattle Children's Hospital
name: Gregory Schmale, MD
role: PRINCIPAL_INVESTIGATOR
References: