Clinical trial NCT03096561: Measurement of Serum Potassium Rate During Accidental Hypothermia.
Official title: A Comparative Study of Serum Potassium Rate Between Peripheral and Central Venous Sample Collection in Patients With Hypothermia Related Cardiac Arrest
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Accidental Hypothermia
Hyperkalemia
Cardiac Arrest
Lead sponsor: University Hospital, Grenoble
Sponsor class: OTHER
Collaborators: name: University Grenoble Alps
name: Centre Hospitalier Universitaire Vaudois
name: Emergency Department, Hospital of Valais, Sion
First posted: 2017-03-30
Enrollment: 12
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Serum Potassium Rate (PR) is a key indicator for medical management of patients with accidental hypothermia particularly for hypothermia related cardiac arrest (CA).

Experts recommend a cut-off value for PR of 12 mmol/l for all hypothermic victims and 8 mmol/l for avalanche casualties. Any patient presenting a PR lower than the cut-off value should be considered for Extracorporeal Rewarming. This therapeutic strategy is vital for patient survival.

However, there is no consensus about what type of vessels should be punctured in order to obtain an accurate potassium rate and what type of measurement technics should be used to measure this potassium rate.

The investigators hypothesize that potassium rate in these patients will differ by 1 mmol/l in blood samples collected from a peripheral vein in contrast to a central vein.

The investigators study is a prospective observational, multicentre study.


Eligibility criteria: Inclusion Criteria:

* Hypothermia related cardiac arrest
* Age \> 18 years
* Core temperature \< 30° C measured in oesophagus at hospital admission

Exclusion Criteria:

* Age \< 18 years
* Known condition of pregnancy or breastfeeding women
* Evidence of trauma-related cardiac arrest
* Cardiac arrest in which reanimation is not justified (frozen body, final stadium of an incurable disease, advance health care directive)

Primary outcomes:
measure: Comparison of potassium rate in central venous blood and blood from a peripheral vein (measured in mmol/l)
timeFrame: 24 hours
Secondary outcomes:
measure: Comparison of potassium rate in venous and arterial blood (measured in mmol/l)
timeFrame: 24 hours
measure: Comparison of potassium rate from laboratory analysis and at bedside via blood gas analyser (measured in mmol/l)
timeFrame: 24 hours
measure: Comparison of the time difference between laboratory analysis and blood gas analyzer at bed side (measured in minutes)
timeFrame: 24 hours
measure: Survival and neurological outcome as measured by the Cerebral Performance Category Scale
timeFrame: 3 months
measure: Study of biological parameters to calculate the Strong Ion Gap (measured in mEq/l) according to the Stewart Approach
timeFrame: 24 hours
Other outcomes:
Locations:
city: Lausanne
country: Switzerland
facility: University Hospital Vaudois
state: Valais
city: Sion
country: Switzerland
facility: Hospital of Valais
state: Valais
Study officials:
References:
citation: Pasquier M, Blancher M, Buse S, Boussat B, Debaty G, Kirsch M, de Riedmatten M, Schoettker P, Annecke T, Bouzat P. Intra-patient potassium variability after hypothermic cardiac arrest: a multicentre, prospective study. Scand J Trauma Resusc Emerg Med. 2019 Dec 16;27(1):113. doi: 10.1186/s13049-019-0694-3.