Clinical trial NCT02986997: Over 2000 Epidural Anesthesias for Percutaneous Nephrolithotomy - a Retrospective Analysis
Official title: Over 2000 Procedures of Epidural Anesthesia for Percutaneous Nephrolithotomy - a Retrospective Analysis
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Nephrolithiasis
Anesthesia, Local
Keywords: epidural anesthesia
prone position
percutaneous nephrolithotomy
Lead sponsor: Medical University of Warsaw
Sponsor class: OTHER
First posted: 2016-12-08
Enrollment: 2000
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients that have PNL procedure performed in the Urology Department (Medical University of Warsaw) 2005-2015

Brief summary: Percutaneous nephrolithotomy (PNL) is a renal lithiasis treatment. It is usually two staged: it begins in the lithotomy position for ureteral catheter placement and retrograde pyelography and, subsequently, an optimal renal access is obtained in the prone position. In most of the centers, the PNL is done under general anesthesia (GA) that is associated with a risk of complications due to putting an intubated, muscle-relaxed, unconscious patient in a prone position. In our Department the procedure is usually performed under epidural anesthesia. The aim of this study was to evaluate the epidural anesthesia performed for PNL over the last decade in the Medical University of Warsaw Urology Department

Detailed description: Percutaneous nephrolithotomy is a renal lithiasis endoscopic treatment. It is usually two staged: it begins in the lithotomy position for ureteral catheter placement and retrograde pyelography and, subsequently, an optimal renal access is obtained in the prone position. The PNL is usually two staged. It begins in the lithotomy position for cystoscopic placement of ureteral catheter and retrograde pyelography and, subsequently, a patient is placed mainly in the prone position for percutaneous access and stone removal. This position offers more options for puncture.

In most of the centers, the PNL is done under GA, that is associated with a risk of complications due to putting an intubated, muscle-relaxed, unconscious patient in a prone position. Other complications, including blood transfusion, nausea and vomiting or fever, are more often observed after the general then after the regional anesthesia; the cost of general anesthesia is also higher. The regional anesthesia that can be performed independently for the PNL includes spinal, epidural or combined spinal-epidural blocks. A segmental epidural block is better than spinal anesthesia in terms of hemodynamic stability, postoperative analgesia, patient's satisfaction and reduced incidence of postoperative nausea and vomiting. For epidural anesthesia it takes longer to act than for spinal one but it allows avoiding the motor block so the patient can change the position from lithotomy into prone himself with a little assistance. The position of a patient should not be changed rapidly right after the spinal anesthesia has been performed, due to the risk of too high anesthesia level and hemodynamic complications.

The aim of the study was to evaluate the epidural anesthesia performed for PNL over the last decade in the Medical University of Warsaw Urology Department.

Eligibility criteria: Inclusion Criteria:

* PNL procedure

Exclusion Criteria:

* no PNL procedure

Primary outcomes:
measure: effectiveness of epidural anesthesia for PNL evaluated by a number of participants having this procedure completed
timeFrame: 5 months
Secondary outcomes:
measure: Epidural anesthesia complication rate evaluated by a number of vessel or spinal puncture
timeFrame: 5 months
Other outcomes:
Locations:
city: Warsaw
country: Poland
Study officials:
affiliation: I Department of Anaesthesiology and Intensive Care
name: Karolina Dobronska, MD
role: PRINCIPAL_INVESTIGATOR
References: