Clinical trial NCT02445105: Mobilizing Community Systems to Engage Families in Early Autism Spectrum Disorder (ASD) Detection & Services
Official title: Mobilizing Community Systems to Engage Families in Early Autism Spectrum Disorder (ASD) Detection & Services
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Autism Spectrum Disorder
Lead sponsor: Florida State University
Sponsor class: OTHER
Collaborators: name: Emory University
name: Weill Medical College of Cornell University
name: Drexel University
name: National Institute of Mental Health (NIMH)
First posted: 2015-05-15
Enrollment: 10857
Sex: ALL
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: HEALTH_SERVICES_RESEARCH

Brief summary: This multisite study will compare the effectiveness of universal screening by 3 community service systems using Autism Navigator, a highly interactive web platform that includes an automated screening tool, information about autism for families, and a professional development course on the early signs of autism and effective evidence-based practice with extensive video footage to rapidly build the capacity for early detection. The investigators will also conduct a multisite pragmatic randomized clinical trial to test the effectiveness of an evidence-based Family Engagement Intervention compared to Autism Navigator Enhanced Practice implemented by the 3 community service systems with children who have a positive autism screen to increase the number of children who are screened, referred for evaluation, receive a diagnosis, and receive community-based EI between 18-27 months of age. This study will impact family engagement in community screening and diagnosis by demonstrating the effectiveness of brief manualized engagement interventions. Findings will advance science by providing researchers with a method for recruiting a community sample, allowing for research at younger ages, which could accelerate science.

Detailed description: The American Academy of Pediatrics recommends screening all children for autism spectrum disorder (ASD) at 18 and 24 months because research indicates that earlier intervention maximizes children's outcomes. The earliest signs of ASD are delays in social communication milestones that appear in the first 2 years and yet most children are not diagnosed until 4-5 years of age. Underserved families are identified even later and significantly underrepresented in intervention research. It is vitally important to mobilize community service systems to impact family engagement throughout the process of screening, evaluation, and early intervention (EI) and to support linkages to public community-based EI in order to address health disparities. This collaborative investigation of 4 universities aims to document the effectiveness of an online automated universal screen for communication delay and autism initially at 18 months of age and decision rule for referral to an ASD evaluation, and to study an evidence-based intervention to increase family engagement and expedite receipt of screening, diagnosis, eligibility for EI, and EI services. The study will focus on the youngest age when ASD can be detected reliably, which is 18 months, and compare the effectiveness of screening and referral by 3 different community service systems: 1) primary care including private and public health care agencies and federally qualified health centers; 2) federal programs such as Women, Infants, and Children (WIC) Food and Nutrition Service and Early Head Start; and 3) the National Black Church Initiative (NBCI). Using the Autism Navigator web-based platform the investigators will expand their capacity for universal ASD screening and referral for diagnosis and determining eligibility by EI providers through the public Individuals with Disabilities Education Act (IDEA) Part C system for children birth to 3 years of age. Innovative web-based technology will be integrated at multiple levels- as the basis for an interactive professional development course to enable these community service systems to efficiently learn about autism and implement a universal broadband and autism-specific screening with seamless automation that links to electronic health records and provides families with web-based tools about autism. This multidisciplinary research team will conduct a multisite pragmatic randomized clinical trial to test the effectiveness of an evidence-based Family Engagement Intervention plus Autism Navigator compared to Autism Navigator Enhanced Practice alone. The investigators will also conduct an exploratory study to test strategies to improve uptake of evidence-based intervention by community-based EI providers through the Part C system. This protocol has the potential to lower the age of screening for ASD to 18 months, which will have important implications for earlier access to intervention and improving ASD service systems and be ready for immediate and rapid implementation in community settings across the US. Findings will advance science by providing researchers with a method for recruiting a population-based sample, allowing for research at younger ages, which could accelerate genetic, neuroscience, and intervention research, and lead to transformative changes to community healthcare delivery.

Eligibility criteria: Inclusion Criteria:

1. Community service providers will be recruited from the specific catchment areas of the 4 sites in Florida, Georgia, New York, and Pennsylvania from 3 different community service systems:

   1. primary care including private, public, and military health care agencies and federally qualified health centers;
   2. federal programs including Women, Infants, and Children (WIC) Food and Nutrition Service, Early Head Start, and other social programs supporting low-income families; and
   3. the National Black Church Initiative (NBCI) and other religious networks serving minorities.
2. Children are screened between 9 and 18 months of age by these community service providers who have agreed to be in this study and their families.

Primary outcomes:
measure: Number of children screened by community service provider
timeFrame: 9 to 36 months of age
measure: Child age at screening by community service provider
timeFrame: 9 to 36 months of age
measure: Child age at referral for evaluation by community service provider
timeFrame: 9 to 36 months of age
measure: Child age at entry into intervention
timeFrame: 9 to 36 months of age
Secondary outcomes:
measure: Child autism symptoms measured with the Autism Diagnostic Observation Schedule
timeFrame: when child is 27 and 36 months of age
measure: Child developmental level measured with the Mullen Scales of Early Learning
timeFrame: when child is 27 and 36 months of age
measure: Child adaptive behavior measured with the Vineland Adaptive Behavior Scales
timeFrame: when child is 27 and 36 months of age
measure: Family measure of resources measured with Family Resource Scale completed by parent
timeFrame: when child is 27 and 36 months of age
measure: Family measure of stress measured with Parenting Stress Index completed by parent
timeFrame: when child is 27 and 36 months of age
measure: Family measure of access to community activities measured with Home and Community Activities Survey completed by parent
timeFrame: when child is 27 and 36 months of age
Other outcomes:
Locations:
city: Tallahassee
country: United States
facility: Florida State University
state: Florida
city: Atlanta
country: United States
facility: Emory University
state: Georgia
city: White Plains
country: United States
facility: Weill Cornell Medical College
state: New York
city: Philadelphia
country: United States
facility: Drexel University
state: Pennsylvania
Study officials:
affiliation: Florida State University
name: Amy M Wetherby, PhD
role: PRINCIPAL_INVESTIGATOR
References: