Clinical trial NCT04951752: Effect of the Transmuscular Quadratus Lumborum Block on Duration of Stay in Recovery
Official title: Effect of the Transmuscular Quadratus Lumborum Block on Duration of Stay in Recovery: a Single-centre, Retrospective, Observational Study Based on Five Selected Randomised Controlled Trials
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Anesthesia, Local
Lead sponsor: Zealand University Hospital
Sponsor class: OTHER
First posted: 2021-07-07
Enrollment: 307
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients scheduled for elective surgery (hemicolectomy, nephrectomy, percutaneous nephrolithiotomy, hysterectomy of caesarean section).

Brief summary: The study will review data collected in 5 previously completed randomised controlled trials with a new primary outcome: to assess whether administration of the transmuscular quadratus lumborum block has an impact on the time an individual patient stays in the postanaesthesia care unit and how much opioid is consumed during this specified time.


Eligibility criteria: Inclusion Criteria:

- Elective Surgery

Exclusion Criteria:

* Inability to cooperate
* Allergy to local anaesthetics or opioids
* Inability to understand Danish
* Regular intake of opioids
* Local infection at site of injection

Primary outcomes:
measure: Duration of recovery
timeFrame: 0-300 minutes
Secondary outcomes:
measure: Total time spent in recovery
timeFrame: 0-300 minutes
measure: Duration of stay at PACU after completed recovery
timeFrame: 0-300 minutes
measure: Total opioid consumption in PACU
timeFrame: 0-300 minutes
measure: Highest pain score in PACU
timeFrame: 0-300 minutes
Other outcomes:
Locations:
city: Roskilde
country: Denmark
facility: Zealand University Hospital
Study officials:
affiliation: Associate Professor, Zealand University Hospital
name: Jens Børglum Neimann, MD, PhD
role: STUDY_DIRECTOR
References:
citation: Dam M, Hansen C, Poulsen TD, Azawi NH, Laier GH, Wolmarans M, Chan V, Bendtsen TF, Borglum J. Transmuscular quadratus lumborum block reduces opioid consumption and prolongs time to first opioid demand after laparoscopic nephrectomy. Reg Anesth Pain Med. 2021 Jan;46(1):18-24. doi: 10.1136/rapm-2020-101745. Epub 2020 Oct 26.
citation: Hansen CK, Dam M, Steingrimsdottir GE, Laier GH, Lebech M, Poulsen TD, Chan VWS, Wolmarans M, Bendtsen TF, Borglum J. Ultrasound-guided transmuscular quadratus lumborum block for elective cesarean section significantly reduces postoperative opioid consumption and prolongs time to first opioid request: a double-blind randomized trial. Reg Anesth Pain Med. 2019 Jul 14:rapm-2019-100540. doi: 10.1136/rapm-2019-100540. Online ahead of print.
citation: Dam M, Hansen CK, Poulsen TD, Azawi NH, Wolmarans M, Chan V, Laier GH, Bendtsen TF, Borglum J. Transmuscular quadratus lumborum block for percutaneous nephrolithotomy reduces opioid consumption and speeds ambulation and discharge from hospital: a single centre randomised controlled trial. Br J Anaesth. 2019 Aug;123(2):e350-e358. doi: 10.1016/j.bja.2019.04.054. Epub 2019 May 30.