Clinical trial NCT03595761: Meningitis With Cerebral Vasculitis in Children
Official title: Retrospective Study About 17 Cases of Child With Bacterial Meningitis Coupled With Cerebral Vasculitis
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Bacterial Meningitis
Keywords: cerebral vasculitis
Lead sponsor: University Hospital, Montpellier
Sponsor class: OTHER
First posted: 2018-07-23
Enrollment: 17
Sex: ALL
Minimum age (years): 1
Maximum age (years): 18
Standard ages: CHILD
ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Children with bacterial meningitis, and cerrbal vasculitis

Brief summary: Purulent meningitis are life-threatening diseases in childhood. Cerebral vasculitis have been described in bacterial meningitis, but poor is known about their physiology and their impact on outcome.

The investigators decide to realize a retrospective mono-centric study carried out at Montpellier university hospital which looks back at a 7-year study(2009-2016).

The Investigators selected purulent meningitis cases based on the bacteriological data provided by the HDB (hospital data base). The Investigators divides in two groups : Group A if patients present a cerebral vasculitis ( radiologic diagnostic by RMI or tomodensitometry), in all, cases the diagnosis of vasculitis was confirmed by a radiologist specialised in neuropaediatrics by a second reading;Group B purulent meningitis with a cerebral vasculitis imaging.

Tuberculous meningitis, meningitis in CSF shunt, and in patients having chemotherapy were excluded.

The investigators report clinical and biological finding, inflammatory marker at the onset. The Investigators register also the clinical evolution and sequelae

Detailed description: Meningitis steel are a cause of death in childhood. Cerebral complication are often responsable of poor prognosis. One of these complication vasculitis is steel not weel understood. There are only few study about it on children.

It is a retrospective study about 17 cases of chil which bacterial meningitis coupled wiethe cerebral vasculitis, the Investigators will describe epidemiology, bacteriology, evolution and corticosteroid treatment in this patients.

Eligibility criteria: Inclusion Criteria:

* bacterial meningitis with LCR confirmation

Exclusion criteria:

* tuberculous meningitis, immunosuppressor treatment, material like DVP

Primary outcomes:
measure: Found a difference demographic data
timeFrame: 1 day
measure: Found a difference demographic data
timeFrame: 1 day
measure: Found a difference Clinical manifestation
timeFrame: 1 day
measure: Found a difference Inflammatory parkers
timeFrame: 1 day
measure: Found a difference Infectious agent
timeFrame: 1 day
Secondary outcomes:
measure: Found a difference in the evolution of the diseases between group A and B
timeFrame: 1 day
measure: In the A group, studying the relationship between prescription of steroids pulse and final outcome and presence of sequelae.
timeFrame: 1 day
Other outcomes:
Locations:
city: Montpellier
country: France
facility: Uhmontpellier
Study officials:
affiliation: UH
name: Eric JEZIORSKI
role: STUDY_DIRECTOR
References: