Clinical trial NCT06811961: Effects of Exercise in Patients with Lipedema
Official title: Effects of Exercise on Edema, Pain, Exercise Capacity, Lower Extremity Muscle Strength and Function in Patients with Lipedema
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: NA
Conditions: Lipedema
Keywords: lipedema
exercise
function
Lead sponsor: Gazi University
Sponsor class: OTHER
First posted: 2025-02-06
Enrollment: 20
Sex: FEMALE
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Randomized controlled prospective study
Primary purpose: TREATMENT

Brief summary: Lipedema is a chronic progressive disease characterized by symmetrical, disproportionate swelling of subcutaneous adipose tissue, which is common in women and mostly seen in the lower extremities and to a lesser extent in the upper extremities. Healthy lifestyle approaches including exercise treatments are very important for lipedema patients in order to prevent disease progression. The aim of this study is to investigate the effects of exercise on edema, pain, exercise capacity, lower extremity muscle strength and function in lipedema patients. Sociodemographic information of the patients, body composition with Tanita InnerScan BC-601-CG device, clinical information regarding lipedema, type and stage of lipedema, inspection, palpation findings will be recorded. Local tissue water percentage will be assessed using Moisturemeter-d compact (MMDc, Delfin Technologies, Kuopio, Finland) device, circumference measurement using tape, pain intensity with Visual Analog Scale, pain threshold with Baseline brand digital algometer device. Muscle strength will be assessed using K-Force hand dynamometer. Functional exercise capacity will be assessed with the 6-minute walk test (6MWT), and lower extremity dysfunction with the lower extremity functional scale. After the assessments are made, the patients will be randomly divided into 2 groups. The patients in the study group will perform group exercises consisting of warm-up, loading and cool-down periods of 40-50 minutes, 2 days a week for 6 weeks, and strengthening exercises applied to the hip muscles and knee extensors with elastic resistance bands, which are decided according to the level of effort perceived by the patient, 3 sets of 10 repetitions, 2 days a week for 6 weeks. The same assessments will be applied to the patients again at the end of the exercise program. The control group will be re-evaluated after 6 weeks with suggestions regarding lipedema and physical activity level, and the obtained data will be compared.


Eligibility criteria: Inclusion Criteria:

* Having a diagnosis of Lipedema,
* Patients with Lipedema stage 1,2 and 3

Exclusion Criteria:

* Individuals with cardiopulmonary, rheumatic or neurological diagnoses that have symptoms severe enough to prevent participation in exercise,
* History of cancer, surgery or trauma that may affect the circulatory system,
* History of liposuction or orthopedic surgery within the last year,
* Individuals who cannot mobilize independently.

Primary outcomes:
measure: Local tissue water percentage
timeFrame: 6 weeks
measure: edema
timeFrame: 6 weeks
measure: Pain severity
timeFrame: 6 weeks
measure: Pain Threshold
timeFrame: 6 weeks
measure: Lower extremity muscle strength
timeFrame: 6 weeks
measure: Lower extremity muscle endurance
timeFrame: 6 weeks
measure: functional exercise capacity
timeFrame: 6 weeks
measure: lower extremity function
timeFrame: 6 weeks
Secondary outcomes:
Other outcomes:
Locations:
city: Ankara
country: Turkey
facility: Gazi University Faculty of Health Sciences
state: Emek
Study officials:
References: