Clinical trial NCT02433275: CHildhood ASthma and Environment Research Study - CHASER Study
Official title: CHildhood ASthma and Environment Research Study - CHASER Study
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Asthma
Lead sponsor: Istituto per la Ricerca e l'Innovazione Biomedica
Sponsor class: OTHER
First posted: 2015-05-04
Enrollment: 1600
Sex: ALL
Minimum age (years): 5
Maximum age (years): 16
Standard ages: CHILD
Accepts healthy volunteers: no
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Children

Brief summary: "CHildhood ASthma and Environment Research study - CHASER study" is an observational longitudinal study in outpatient clinic of Pediatric Allergology \& Pulmonology (PAP) of Respiratory Disease Research Center (RDRC) within the Institute of Biomedicine and Molecular Immunology (IBIM) of the National Research Council (CNR) of Palermo (RDRC-IBIM CNR), Italy.

The first phase - transversal study will identify determinants of pediatric asthma control

The second phase - longitudinal study, in patients with persistent asthma, will be focused on:

* predictors for asthma exacerbations and loss of control
* real life adherence to asthma therapy guidelines
* phenotypic characterization through the collection of saliva samples
* assessment of alterations and inflammatory changes in the nasal mucosa through nasal brushing
* evaluation of the presence of 8-isoprostane, nicotine, cotinine and bisphenol-A through urine analysis.

Chaser Project is expected to improve the knowledge of pediatric asthma in patients with different level of control, identifying predictors for asthma exacerbations and loss of control.


Eligibility criteria: Inclusion Criteria:

* age 5-16 years
* asthma
* not asthma

Exclusion Criteria:

* chest deformity
* active smoking

Primary outcomes:
measure: Asthma
timeFrame: 5 years
Secondary outcomes:
measure: Measures from saliva samples
timeFrame: 5 years
measure: Measures from nasal brushing
timeFrame: 5 years
measure: Measures from urine samples
timeFrame: 5 years
Other outcomes:
Locations:
city: Palermo
country: Italy
facility: Institute of Biomedicine and Molecular Immunology, IBIM
Study officials:
References:
citation: Cilluffo G, Ferrante G, Fasola S, Malizia V, Montalbano L, Ranzi A, Badaloni C, Viegi G, La Grutta S. Association between Asthma Control and Exposure to Greenness and Other Outdoor and Indoor Environmental Factors: A Longitudinal Study on a Cohort of Asthmatic Children. Int J Environ Res Public Health. 2022 Jan 4;19(1):512. doi: 10.3390/ijerph19010512.
citation: Erkkola RA, Virta LJ, Vahlberg T, Jartti T. Prednisolone for the first rhinovirus induced wheezing reduces use of respiratory medication. Pediatr Allergy Immunol. 2022 Jan;33(1):e13668. doi: 10.1111/pai.13668. Epub 2021 Sep 29. No abstract available.
citation: Cilluffo G, Han YY, Ferrante G, Dello Russo M, Lauria F, Fasola S, Montalbano L, Malizia V, Forno E, La Grutta S. The Dietary Inflammatory Index and asthma burden in children: A latent class analysis. Pediatr Allergy Immunol. 2022 Jan;33(1):e13667. doi: 10.1111/pai.13667. Epub 2021 Sep 27.