Clinical trial NCT02660749: The Effect Of Tramadol, Metamizol and Dexketoprofen Combination On Chronic Pain Development After Heart Surgery
Official title: The Effect Of Tramadol, Metamizol and Dexketoprofen Combination On Chronic Pain Development After Heart Surgery
Study type: OBSERVATIONAL
Overall status: UNKNOWN
Conditions: Heart Surgery
Lead sponsor: Tobb University of Economics and Technology
Sponsor class: OTHER
First posted: 2016-01-21
Enrollment: 80
Sex: ALL
Minimum age (years): 20
Maximum age (years): 70
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: yes
Observational model: CASE_CONTROL
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Female and male are being participant.

Brief summary: Non Coronary Heart Surgery scheduled for the study , in patients with acute postoperative period Use of tramadol retard, metamizol and dekxketoprofen the effects on pain and character has been seen in the chronic phase targeted.

Detailed description: This prospective study analyzed surgical thoracotomy and sternotomy patients treated with analgesic drug when higher than 4 regularly. Clinical parameters include general demographics, preoperative and postoperative clinical examination status, pain scores, neuropathic pain scores, medication side effects, additional analgesic, antiemetic and lacsatif needs, vital functions, chest drains, blood transfusion needs, duration of cardiopulmonary bypass, cross clamp time and anaesthesia time. The screening tests for neuropathic pain is the Douleur Neuropathique 4. Using at postopertative 3.month DN4 questionnaires predict persistent postoperative neuropathic pain.

Eligibility criteria: Inclusion Criteria:

* Patients included between 20-70 years
* ASA 1-4
* Euroscore value lower than 7
* Undergoned non coronary heart surgery (minithoracotomy and sternotomy)
* Intensive care has been discharged from the service in 24 hours , with patients given tramadol retard , metamizol, Dexketoprofen on postoperatif first day to discharged from the hospital.

Exclusion Criteria:

* Diabetes mellitus
* Chronic renal failure
* COPD
* Uncontrolled hypertension
* Epilepsy
* Psychiatric disease
* Malignancy
* Patients with a history of cerebrovascular disease
* Patients with ischemia
* Patients suffering from chronic pain and analgesic use
* Patients taking antidepressants and antiepileptic drug
* Off-pump technique used or redo undergo cases
* Ongoing postoperative time thoracic or mediastinal drains more than 48 hours remaining patients, bleeding or patients who received repeated revisions due to infection
* More than 24 hours remaining in intensive care patients
* Patients with long discharge duration 1 week
* Patients who discontinued due to side effects of tramadol may begin after medicines.
* Postoperative wound infection.

Primary outcomes:
measure: neuropathic pain assesement by DN4 score after minithoracotomy and sternotomy
timeFrame: outcome measure assessed 3 months after the surgery
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
affiliation: Baskent University Department of Anesthesiology
name: H. Evren Eker, Ass Prof
role: STUDY_DIRECTOR
References: