Clinical trial NCT05558553: Are Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio, and Systemic Immune Inflammation Score Values Indicators for Postoperative Pain?
Official title: Are Neutrophil-Lymphocyte Ratio, Platelet-Lymphocyte Ratio, and Systemic Immune Inflammation Score Values Indicators for Postoperative Pain?
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Postoperative Pain Status of Patients Who Underwent Elective Laparoscopic Cholecystectomy
Keywords: Laparoscopic cholecystectomy
posoperative pain
neutrophil lymphocyte ratio
platelet lymphocyte ratio
systemic immune inflammation score
tramadol consumption
Lead sponsor: Samsun University
Sponsor class: OTHER
First posted: 2022-09-28
Enrollment: 2
Sex: ALL
Minimum age (years): 18
Maximum age (years): 75
Standard ages: ADULT
OLDER_ADULT
Observational model: OTHER
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Patients who have undergone elective laparoscopic cholecystectomy

Brief summary: Postoperative pain status of patients who underwent elective laparoscopic cholecystectomy.

Detailed description: Subject Researched:

Postoperative pain is a result of the inflammatory response to surgical trauma. Local inflammatory mediator response triggered by surgical incision, dissection, retraction, etc. causes an increase in nociceptor sensitivity and hyperalgesia, resulting in the perception of postoperative pain. With the acute phase response caused by surgical trauma, tissue damage is brought under control, infection is limited and the healing process begins. During the inflammatory response, the level of leukocytes in the blood also changes. Neutrophil/Lymphocyte ratio (NLR), Platelet/Lymphocyte ratio (PLR) and Systemic immune inflammation score (SII) are inexpensive and easily accessible biomarkers calculated from routine hemogram parameters and shown to be helpful in disease investigations and evaluation of treatment response. In this study, the relationship between biomarkers and postoperative pain status due to surgery will be investigated

Eligibility criteria: Inclusion Criteria:

1. Patients aged 18-75 years who underwent elective laparoscopic cholecystectomy.
2. Patients with ASA status1-2-3

Exclusion Criteria:

1. Emergency operated patients
2. Patients switched to open surgery
3. Patients allergic to tramadol
4. Those allergic to paracetamol
5. Those allergic to tenoxicam
6. Patients who cannot use the patient-controlled analgesia device
7. Those with hematological disorders
8. Those receiving immunosuppressive therapy
9. Those with inflammatory disease
10. Those with gastrointestinal tumors
11. Those with rheumatic disease
12. Those with uncontrolled diabetes
13. Those with chronic organ failure
14. Those who use corticosteroids
15. Opioid users
16. Those who have recently had an attack of cholecystitis, pancreatitis

Primary outcomes:
measure: postoperative analgesic consumption
timeFrame: 24 hours
Secondary outcomes:
measure: postoperative pain score
timeFrame: 24 hours
Other outcomes:
Locations:
city: Samsun
country: Turkey
facility: SAMSUN UNIVERSITY Samsun Training and research hospital
city: Samsun
country: Turkey
facility: Samsun Üniversity
Study officials:
affiliation: responsibl investigator
name: Şenay Canikli Adıgüzel
role: STUDY_DIRECTOR
References:
citation: Tasargol O. A Prospective Study on the Predictability of Propofol Injection Pain. Cureus. 2020 Feb 10;12(2):e6945. doi: 10.7759/cureus.6945.