Clinical trial NCT03614871: Snuff Use, Smoking, Periodontal Health and Premature Death: 30-year Study
Official title: Snuff Use, Smoking, Periodontal Health and Premature Death: 30-year Study
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Tobacco Use
Periodontitis
Keywords: Tobacco
Calculus
Gingiva
Oral hygiene
Periodontitis
Biofilm
Lead sponsor: University of Helsinki
Sponsor class: OTHER
Collaborators: name: Karolinska Institutet
First posted: 2018-08-03
Enrollment: 1676
Sex: ALL
Minimum age (years): 30
Maximum age (years): 40
Standard ages: ADULT
Accepts healthy volunteers: yes
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Swedish national database sample

Brief summary: Snuff use and smoking associated with poor periodontal health, especially if used together.

Detailed description: Aim: The investigators investigated how snuff use and smoking affect periodontal health parameters and mortality in a Swedish cohort, hypothesizing that snuff use increases the risks.

Material and methods: Study cohort of 1 532 subjects aged 30 to 40 (758 men and 774 women) from Stockholm area was clinically examined and followed up from 1985 to 2015. Associations were analysed between periodontal health parameters, snuff use, smoking and age of death. For analyses, all subjects were classified into four groups: "dual-users" (current and ex-snuffers, current and ex-smokers); "pure snuffers" (current and ex-snuffers); "pure smokers" (non-snuffers, current and ex-smokers) and "non-users" (non-snuffers and non-smokers). Cross-tabulation, chi-square and Fisher's exact tests were used.

Eligibility criteria: Inclusion Criteria:

* In 1985-1986 a sample was selected from the registry file of all inhabitants of the Stockholm area, of people born on the 20th of any month from 1945 to 1954.The sample comprised 3200 people. They were informed about the purpose of the study and called for clinical investigation. 1681 (52.5%) individuals, 840 men and 841 women, participated in the study. From the remaining 1519 non-respondents to the initial call, 100 randomly selected subjects, 45 men and 55 women, were reinformed and persuaded and finally agreed to participate in this investigation. They were used as a drop-out control sample.

Exclusion Criteria:

* Other people

Primary outcomes:
measure: Periodontal Pockets
timeFrame: 1985
measure: Missing teeth
timeFrame: 1985
measure: Gingival Index (GI)
timeFrame: 1985
measure: Premature death
timeFrame: From year 1985 to year 2015
measure: Plaque Index (PI)
timeFrame: 1985
measure: Calculus Index (CI)
timeFrame: 1985
Secondary outcomes:
Other outcomes:
Locations:
Study officials:
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