Clinical trial NCT06637956: The Effect of Intranasally Administered Nitroglycerin on Hemodynamic Response to Laryngoscopy and Intubation Among Patients Undergoing Coronary Artery Bypass Grafting (CABG) Surgery
Official title: The Effect of Intranasally Administered Nitroglycerin on Hemodynamic Response to Laryngoscopy and Intubation Among Patients Undergoing Coronary Artery Bypass Grafting (CABG) Surgery
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Coronary Artery Bypass Grafting
Keywords: Intranasal
nitroglycerin
hemodynamic response
larayngoscopy
intubation
coronary artery bypass grafting
Lead sponsor: RESnTEC, Institute of Research
Sponsor class: OTHER
First posted: 2024-10-15
Enrollment: 58
Sex: ALL
Minimum age (years): 35
Maximum age (years): 60
Standard ages: ADULT
Accepts healthy volunteers: no
Allocation: RANDOMIZED
Intervention model: PARALLEL
Primary purpose: TREATMENT

Brief summary: Numerous preventive medications have been used to lessen the cardiovascular response to laryngoscopy and intubation. Though some advantages have been noted, most of these treatments have not been found to be completely satisfying. However, nitroglycerin is the most widely utilized medicine due to its fast effect, short half-life, and absence of sedative qualities.

Detailed description: The circulatory system under compromise is less resilient to the effects of general anaesthesia. Inducing anaesthesia is a crucial step for cardiac patients because their impaired circulatory systems are less tolerant to depression. During coronary artery bypass grafting surgery, the primary objective of general anesthesia is to reduce sympathetic response to uncomfortable stimuli, including laryngoscopy, intubation, skin incision, sternal splitting, and spreading. A rise in blood pressure is one of the hemodynamic reactions that is typically associated with tracheal intubation and laryngoscopy. The impact of intra nasally delivered nitroglycerin on blood pressure response to laryngoscopy and intubation in patients having non-cardiac surgery is currently contentious; however, this study focus on coronary artery bypass grafting surgery patients.

Eligibility criteria: Inclusion Criteria:

* Both genders
* Patients undergoing coronary artery bypass grafting surgery.
* Patients aged 35-60 years.
* Ejection Fraction between 50-60%.
* American Society of Anesthesiologists Classification 3-4.

Exclusion Criteria:

* Known hypersensitivity to nitroglycerin.
* Anticipated difficult airway.
* Emergency surgery.

Primary outcomes:
measure: Mean aterial pressure
timeFrame: 5 minutes post intubation
measure: Heart rate
timeFrame: 5 minutes post intubation
measure: Systolic blood pressure
timeFrame: 5 minutes post intubation
measure: Diastolic blood pressure
timeFrame: 5 minutes post intubation
Secondary outcomes:
Other outcomes:
Locations:
city: Lahore
country: Pakistan
facility: Department of Anesthesia, Rashid Latif Medical College
state: Punjab
Study officials:
affiliation: Department of anesthesia Rashid Latif Medical college, Lahore, Pakistan
name: Shehryar Ahmed, MS
role: PRINCIPAL_INVESTIGATOR
affiliation: Department of Anesthesia, Shahida Islam Teaching Hospital, Lodhran, Pakistan
name: Syed Shakeel Ahmed, FCPS
role: PRINCIPAL_INVESTIGATOR
References: