Clinical trial NCT02887105: Memory and Emotion in Acute and Chronic Phases of Cerebrovascular Accident
Official title: Memory and Emotion in Acute and Chronic Phases of Cerebrovascular Accident
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Cerebrovascular Accident
Lead sponsor: Central Hospital, Nancy, France
Sponsor class: OTHER
First posted: 2016-09-01
Enrollment: 76
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients hospitalized for a cerebrovascular accident

Brief summary: The purpose is to determine the relationship between anxiety and cognitive performances in patients with acute and chronic phases of cerebrovascular accident (CVA). Data from neuropsychological assessment concerning cognitive processes (working and episodic memory) sensitive to different dimensions of anxiety will be analyzed.

The secondary purpose is to evaluate how some neurological (hemispherical lateralization of lesions), psychological (depression) and demographic (quality of life) variables can increase the effects of different dimensions of anxiety on cognitive processes, during the acute and/or chronic phase of CVA.

Detailed description: Data will be collected during usual neuropsychological evaluation and cerebral imagery examination (NIHSS, Rankin scale) of patients in acute (0-1 month) and chronic (6 months) phases of CVA.

Eligibility criteria: Inclusion Criteria:

* Acute phase of carotid, vertebrobasilar or lacunar cerebrovascular accident with ischemic or hemorrhagic origin
* Right-handed
* Possible cooperation: understanding of French instructions
* Normal or corrected vision
* Normal or corrected hearing
* Mini-mental state examination score higher than pathologic threshold according to age and sociocultural level of patient
* Possible follow up of patient

Exclusion Criteria:

* Hearing problems
* Vision problems
* Right hemiplegia or acute monoparesis of right upper limb
* Hemispatial neglect
* Apraxia
* Psychiatric or neurological history possibly interfering with neuropsychological evaluation
* Important defect of working memory or executive functions

Primary outcomes:
measure: State of anxiety evaluated with STAI-YA scale
timeFrame: up to 1 month (from CVA)
measure: State of anxiety evaluated with STAI-YA scale
timeFrame: 6 months (from CVA)
measure: Anxiety proneness evaluated with STAI-YB scale
timeFrame: up to 1 month (from CVA)
measure: Anxiety proneness evaluated with STAI-YB scale
timeFrame: 6 months (from CVA)
measure: Apprehension anxiety evaluated with Penn State Worry Questionnaire
timeFrame: up to 1 month (from CVA)
measure: Apprehension anxiety evaluated with Penn State Worry Questionnaire
timeFrame: 6 months (from CVA)
measure: Evaluation of working memory updating with N-back verbal and visuospatial task
timeFrame: up to 1 month (from CVA)
measure: Evaluation of working memory updating with N-back verbal and visuospatial task
timeFrame: 6 months (from CVA)
measure: Evaluation of working memory inhibition with Stimulus-response compatibility task
timeFrame: up to 1 month (from CVA)
measure: Evaluation of working memory inhibition with Stimulus-response compatibility task
timeFrame: 6 months (from CVA)
measure: Evaluation of working memory flexibility with Switching task
timeFrame: up to 1 month (from CVA)
measure: Evaluation of working memory flexibility with Switching task
timeFrame: 6 months (from CVA)
measure: Evaluation of verbal working memory with Wechsler memory scale
timeFrame: up to 1 month (from CVA)
measure: Evaluation of verbal working memory with Wechsler memory scale
timeFrame: 6 months (from CVA)
measure: Evaluation of visuospatial working memory with Wechsler memory scale
timeFrame: up to 1 month (from CVA)
measure: Evaluation of visuospatial working memory with Wechsler memory scale
timeFrame: 6 months (from CVA)
measure: Evaluation of visual episodic memory with Rey and Taylor figure test
timeFrame: 6 months (from CVA)
measure: Evaluation of verbal episodic memory with RL/RI 16 item test
timeFrame: 6 months (from CVA)
Secondary outcomes:
measure: Hemispheric lateralization of lesions detected with MRI
timeFrame: up to 1 month from CVA
measure: Depression state evaluated with Back depression inventory
timeFrame: up to 1 month (from CVA)
measure: Depression state evaluated with Back depression inventory
timeFrame: 6 months (from CVA)
measure: Quality of life evaluated with SF-36 test
timeFrame: after 6 months from CVA
Other outcomes:
Locations:
city: Metz
country: France
facility: Service de Neurologie - Hôpital Bon Secours - CHR de Metz-Thionville
city: Nancy
country: France
facility: Service de Neurologie - Hôpital Central - CHU de Nancy
Study officials:
affiliation: Service de Neurologie - Unité Neurovasculaire - Hôpital Central Nancy
name: Xavier DUCROCQ, Pr
role: PRINCIPAL_INVESTIGATOR
References: