Clinical trial NCT02884583: Association Between Asthma and Food Allergy
Official title: Association Between Asthma and Food Allergy in Children and Adults
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Food Allergy Suspected
Food Allergy Proved
Keywords: Food allergy
asthma
Predictive factor
Exacerbation
Prevalence
Lead sponsor: University Hospital, Montpellier
Sponsor class: OTHER
First posted: 2016-08-31
Enrollment: 200
Sex: ALL
Minimum age (years): 5
Maximum age (years): 65
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: DIAGNOSTIC

Brief summary: Prevalences of food allergies and asthma increased in the population during the last decades. These two pathologies, responsible for a real burden, are often associated and are to be considered as comorbidities; this aspect is more and more studied in the literature and many authors tried to find a link between diets and asthma. The narrow link between these two atopic pathologies and the fact that food allergy can come along with respiratory symptoms also in patients without history of asthma must be better understood, considered into the management of food allergy. The main objective of this study is to study the prevalence of signs and/or symptoms suggestive of bronchial hyperreactivity, during an oral food challenge (OFC) in patients older than 5 years. The secondary objective is to study the risk factors to develop asthma during a food allergy reaction.

This historical-prospective single center study , was realized in the Allergy Unit of the University Hospital of Montpellier. All the patients having been hospitalized for a positive OFC between January, 2001 and January, 2016 were included. The diagnosis of asthma was established according to the recommended international clinical and physiological criteria. Prevalence of bronchial hyperreactivity during OFC among those with positive OFC, was calculated. The search for risk factors was made by a logistic regression univariate then multivariate, completed by a decision tree.


Eligibility criteria: Inclusion Criteria:

* Patient hospitalized for oral food challenge at the hospital

Exclusion Criteria:

* Patient want to leave the protocol
* Patient take medication forbidden during the study

Primary outcomes:
measure: Number of patient with bronchospasm in OFC
timeFrame: up to 3 hours
Secondary outcomes:
measure: Questionnaire for the assessment of the responsible food of allergy
timeFrame: up to 3 hours
measure: the eliciting dose
timeFrame: up to 3 hours
measure: The grade of the allergic reaction shown during the last food ingestion of the concerned food
timeFrame: up to 3 hours
measure: The presence of one or several sensitisations associated with respiratory allergens
timeFrame: up to 3 hours
measure: The level of specific immunoglobulin E of the concerned food
timeFrame: up to 3 hours
measure: The time of appearance of the first signs of atopy
timeFrame: up to 3 hours
measure: questionnaire for the assessment of the mode of clinical expression of food allergies
timeFrame: up to 3 hours
Other outcomes:
Locations:
city: Montpellier
country: France
facility: University hospital of Montpellier
Study officials:
References: