Clinical trial NCT06824571: Effects of Taurine Supplementation on Repetitive Sprint Performance and Exhaustion Time in College Students Under High-Temperature and High-Humidity Conditions
Official title: Effects of Taurine Supplementation on Repetitive Sprint Performance and Exhaustion Time in College Students Under High-Temperature and High-Humidity Conditions
Study type: INTERVENTIONAL
Overall status: COMPLETED
Phase: NA
Conditions: Exercise Performance in Extreme Environments
Lead sponsor: Xi'an Medical University
Sponsor class: OTHER
First posted: 2025-02-13
Enrollment: 16
Sex: ALL
Minimum age (years): 20
Maximum age (years): 26
Standard ages: CHILD
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: CROSSOVER
Intervention model description: This study utilized a single-blind, randomized, crossover-controlled design to evaluate the effects of taurine supplementation at varying doses (6g, 4g, 1g) and placebo on exercise performance under high-temperature and high-humidity conditions. Each participant received all four interventions (high-dose, medium-dose, low-dose, and placebo) in randomized order, with a washout period between treatments to minimize carryover effects. This design allows each participant to serve as their own control, enhancing the precision of the comparisons across conditions.
Primary purpose: BASIC_SCIENCE

Brief summary: This study is designed to evaluate the effects of acute pre-exercise taurine supplementation at different doses on the performance of college students during exhaustive exercise and subsequent repetitive sprint (RS) activities in a high-temperature, high-humidity environment. Sixteen college students (8 male, 8 female) will participate in a single-blind, randomized, crossover-controlled trial. Participants will be divided into four groups: high-dose taurine (6g), medium-dose taurine (4g), low-dose taurine (1g), and placebo. Key performance metrics such as peak power (PP), mean power (MP), fatigue index (FI), exhaustion time (ET), reverse vertical jump height, heart rate (HR), blood lactate (BLA), and ratings of perceived exertion (RPE) will be measured.

The objective of this study is to assess how taurine supplementation influences exercise performance under these challenging environmental conditions. This study will help to better understand taurine's potential effects on exercise performance and contribute to nutritional strategies for athletes exposed to extreme conditions.

Detailed description: This study is designed to evaluate the effects of taurine supplementation on exercise performance under extreme environmental conditions of high temperature and high humidity. The primary goal is to investigate whether taurine supplementation can enhance performance during exhaustive exercise and subsequent repetitive sprints (RS). Sixteen college students (8 male, 8 female) will participate in a single-blind, randomized, crossover-controlled trial. Participants will be divided into four groups receiving either high-dose (6g), medium-dose (4g), low-dose (1g) taurine supplementation, or placebo.

The study will involve a protocol with exhaustive exercise followed by six repetitive sprints. Performance metrics such as peak power (PP), mean power (MP), and fatigue index (FI) will be recorded. Additionally, physiological parameters, including heart rate (HR) and blood lactate (BLA), as well as subjective measures like ratings of perceived exertion (RPE), will be monitored. A standardized measurement protocol will be used to ensure consistency and accuracy across trials.

Eligibility criteria: Inclusion Criteria:

* School students
* Aged between 18 and 28 years
* No exercise-related risk, as indicated by a "no" response to all questions in the Physical Activity Readiness Questionnaire (PAR-Q)
* No taurine-based supplements consumed in the last month.

Exclusion Criteria :

* Individuals who do not meet the inclusion criteria
* Individuals with a history of cardiovascular issues, respiratory problems, or any condition that may impair exercise performance
* Participants who did not provide a "no" response to all questions in the Physical Activity Readiness Questionnaire (PAR-Q)
* Participants who consumed taurine-based supplements in the month preceding the study.

Primary outcomes:
measure: Change from Baseline in Peak Power (Watts)
timeFrame: Measured at the end of each sprint on Day 1 and Day 7.
measure: Change from Baseline in Mean Power (Watts)
timeFrame: Measured after all 6 sprints on Day 1 and Day 7.
measure: Change from Baseline in Fatigue Index (%/s)
timeFrame: Measured across all 6 sprints on Day 1 and Day 7.
measure: Change from Baseline in Exhaustion Time (seconds or minutes)
timeFrame: Measured at the point of exhaustion during exhaustive exercise on Day 1 and Day 7.
measure: Change from Baseline in Blood Lactate Levels (mmol/L)
timeFrame: Measured at baseline (pre-exercise), immediately after exercise, and at specific recovery intervals on Day 1 and Day 7.
Secondary outcomes:
measure: Change from Baseline in Ratings of Perceived Exertion (RPE)
timeFrame: Measured continuously during exhaustive exercise and repetitive sprint activity on Day 1 and Day 7.
Other outcomes:
Locations:
city: Beijing
country: China
facility: Capital University of Physical Education and Sports
state: Beijing
Study officials:
affiliation: Xi'an Medical University
name: Xiaodong Cheng, PhD
role: PRINCIPAL_INVESTIGATOR
References: