Clinical trial NCT05641493: A Phase Ib/II Clinical Trial to Evaluate the Safety and Efficacy of HLX208+HLX10 in NSCLC With BRAF V600E Mutation
Official title: A Phase Ib/II Clinical Trial to Evaluate the Safety, Tolerability, Pharmacokinetics, and Preliminary Efficacy of HLX208 （BRAF V600E Inhibitor） Combined With Serplulimab（HLX10, Anti-PD-1 Antibody） in Advanced NSCLC Patients With BRAF V600E Mutation.
Study type: INTERVENTIONAL
Overall status: RECRUITING
Phase: PHASE1
PHASE2
Conditions: Non Small Cell Lung Cancer
Keywords: HLX208
HLX10
BRAF V600E mutation
Lead sponsor: Shanghai Henlius Biotech
Sponsor class: INDUSTRY
First posted: 2022-12-07
Enrollment: 49
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: An open-label, multicenter phase Ib/II clinical study to evaluate safety, tolerability, pharmacokinetics, and efficacy of HLX208 (BRAF V600E Inhibitor) combined with HLX10 （anti-PD-1 monoclonal antibody）in advanced NSCLC patients with BRAF V600 mutation.

Detailed description: This is an open-label, multicenter phase Ib/II clinical study to evaluate safety, tolerability, pharmacokinetics, and efficacy of HLX208 (BRAF V600E Inhibitor) combined with HLX10 （anti-PD-1 monoclonal antibody）in advanced NSCLC patients with BRAF V600 mutation.

For the phase Ib study, HLX208 is administered orally at two dose levels of 600mg BID or 900 mg BID. And HLX10 is administered intravenously at a fixed dose of 300mg every 3 weeks.

For the phase II study, HLX208 is administered orally with the RP2D dose. And HLX10 is administered intravenously at a fixed dose of 300mg every 3 weeks.

Eligibility criteria: Inclusion Criteria:

1. ≥18 and ≤75 years old of age (in phase Ib study) or ≥18 and ≤80 years old of ag (in phase II study) at the time of informed consent.
2. Signed written informed consent.
3. BRAF V600E mutant advanced solid tumors (in phase Ib study) or advanced NSCLC (in phase II study) patients with positive PD-L1 expression (TPS or TC≥1%).
4. Previous failure of standard therapy, intolerance to standard therapy, lack of standard therapy, or currently unsuitable for standard therapy.
5. Prior systemic anti-neoplastic therapy (chemotherapy, radiotherapy, targeted therapy, or traditional Chinese medicine with anti-neoplastic indications) must have been ≥ 2 weeks from the first dose in this study with treatment-related AE resolved to NCI-CTCAE Grade ≤ 1 (except for alopecia)
6. Eastern Cooperative Oncology Group (ECOG) Performance Status of 0-1.
7. Expected survival time ≥ 3 months.
8. At least one measurable target lesion per RECIST v1.1 (brain metastasis could not be considered as the only measurable lesion).
9. With normal major organ functions (no blood transfusions or treatment with colony-stimulating factor within 14 days prior to the first dose in this study).
10. Be able to swallow and retain oral medication and must not have any clinically significant gastrointestinal abnormalities that may alter absorption such as malabsorption syndrome or major resection of the stomach or bow
11. Fertile subjects (male or female) must agree to take effective contraceptive measures from the time of signing the ICF until 90 days after the last dose of HLX208 or 6 months after the last dose of HLX10. Female subjects of childbearing potential must complete a pregnancy test with a negative result within 7 days prior to the first dose.

Exclusion Criteria:

1. For subjects in phase II study: previous treatment with BRAF inhibitors or MEK inhibitors or previous treatment with T cell co-stimulation or immune checkpoint therapy.
2. Known EGFR mutations or ALK rearrangements (except in subjects with EGFR mutations whose disease has progressed after previous EGFR inhibitor treatment).
3. Received strong CYP3A inhibitors or inducers treatment within 1 week prior to the first dose of investigational product.
4. Received major surgery within 28 days prior to the first dose of investigational product. A major surgery is defined as a surgery that takes at least 3 weeks of postoperative recovery before receiving treatment in this study.
5. With uncontrolled pleural effusion, pericardial effusion, or ascites.
6. With symptomatic brain or meningeal metastases (unless the patient has been treated for \>3 months, there is no evidence of progression on imaging within 4 weeks prior to the first dose, and the tumor-related clinical symptoms are stable).
7. With active pulmonary tuberculosis. Patients with previous and current interstitial pneumonia, pneumoconiosis, radiation pneumonitis, drug-related pneumonitis, or severe impaired pulmonary function that may interfere with the detection and management of suspected drug-related pulmonary toxicity.
8. With any serious infection requiring systemic anti-infective therapy within 14 days prior to the first dose of the investigational product.
9. History of other malignant tumors (except for cured carcinoma in situ of the cervical or basal cell carcinoma of the skin) within two years prior to the first dose of investigational product.
10. Being positive (+) for hepatitis B surface antigen (HBsAg) or positive (+) for hepatitis B core antibody (HBcAb), and with hepatitis B virus deoxyribonucleic acid (HBV-DNA) ≥ 2500 copies/mL or 500 IU/mL.
11. Being positive (+) for HCV RNA.
12. Being positive (+) human immunodeficiency virus (HIV) antibody.
13. History of serious cardiovascular and cerebrovascular diseases.
14. Systemic treatment with corticosteroids (\> 10 mg/day prednisone or equivalent) or other immunosuppressive agents within 14 days prior to the first dose of the investigational product or during the study. In the absence of active autoimmune disease, subjects are allowed to use inhaled or topical steroids, or adrenal hormone replacement therapy at an effective dose equivalent to ≤10 mg/day prednisone.
15. Known active or suspected autoimmune diseases. Subjects with autoimmune related hypothyroidism receiving thyroid hormone replacement therapy are allowed to participate in the study. Subjects with stable type 1 diabetes receiving insulin therapy are allowed to participate in the study.
16. Known alcohol of or drug abuse.
17. Pregnant or lactating women.
18. Received live vaccine within 28 days prior to the first dose of investigational product.
19. Have other conditions not suitable for inclusion as judged by the investigator.

Primary outcomes:
measure: MTD (for phase Ib study)
timeFrame: From first dose to the end of Cycle 1 (each cycle is 3 weeks).
measure: DLT (for phase Ib study)
timeFrame: From first dose to the end of Cycle 1 (each cycle is 3 weeks).
measure: ORR (for phase II study)
timeFrame: up to approximately up to 24 months
Secondary outcomes:
measure: PFS
timeFrame: approximately up to 36 months
measure: DCR
timeFrame: approximately up to 24 months
measure: DOR
timeFrame: approximately up to 24 months
measure: TTR
timeFrame: approximately up to 24 months
measure: 12-month OS rate
timeFrame: 12 months
measure: 6-month OS rate
timeFrame: 6 months
measure: OS
timeFrame: approximately up to 48 months
measure: 12-month PFS rate
timeFrame: 12 months
measure: 6-month PFS rate
timeFrame: 6 months
measure: SAE
timeFrame: approximately up to 48 months
measure: AUC0-T
timeFrame: From First administration of HLX 208 to 12 weeks.
measure: AUC0-∞
timeFrame: From First administration of HLX 208 to 12 weeks.
measure: Cmax
timeFrame: From First administration of HLX 208 to 12 weeks.
measure: Tmax
timeFrame: From First administration of HLX 208 to 12 weeks.
measure: t1/2
timeFrame: From First administration of HLX 208 to 12 weeks.
measure: AUCss
timeFrame: From First administration of HLX 208 to 12 weeks.
Other outcomes:
measure: Association of biomarkers with efficacy
timeFrame: approximately up to 48 months
Locations:
city: Shanghai
country: China
facility: Shanghai Chest Hospital, Shanghai Jiao Tong University, School of Medicine
Study officials:
affiliation: Shanghai Chest Hospital, Shanghai Jiao Tong University School Of Medicine
name: Shun Lu, Dr.
role: PRINCIPAL_INVESTIGATOR
References: