Clinical trial NCT06524661: Anterior Segment Changes After Pars Plana Vitrectomy With SO Using AS-OCT
Official title: Anterior Segment Changes After Pars Plana Vitrectomy With Silicone Oil Tamponade And After Silicone Oil Evacuation Using AS-OCT.
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Glaucoma
Keywords: ASOCT
Glaucoma
Silicone
vitrectomy
angle
Lead sponsor: Minia University
Sponsor class: OTHER
First posted: 2024-07-29
Enrollment: 30
Sex: ALL
Minimum age (years): 16
Maximum age (years): 75
Standard ages: CHILD
ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Patients who are phakic with rhegmatogenous retinal detachment

Brief summary: To evaluate changes in ACA induced by pars plana vitrectomy with SO 1000cs injection in vitreo-retinal surgery in phakic eyes using AS-OCT and changes in the IOP preoperatively, post-operatively and post-silicone oil evacuation.

Detailed description: Abstract Introduction Ocular hypertension and secondary glaucoma are relatively common and serious complications in silicone filled eyes which may end in blindness. Reports have described the percentage of incidence to be within 3 - 30 % of silicon filled eye which are complicated with secondary glaucoma. \[1\] Aim of study Evaluation of changes in anterior chamber angle and intra-ocular pressure (IOP) in patients with rhegmatogenous retinal detachment (RRD) who underwent pars plana vitrectomy (PPV) with silicone oil (SO) 1000cs tamponade and after silicone oil evacuation.

Population The study was a prospective interventional study. The study included 30 eyes from 30 patients with rhegmatogenous retinal detachment (RRD) who are going to undergo PPV with SO injection. The study was conducted at Ophthalmology department, Minia University Hospital in Egypt between April 2023 and April 2024.

Eligibility criteria: Inclusion Criteria:

* • Patients with rhegmatogenous retinal detachment who are going to undergo vitreoretinal surgery with silicone oil 1000cs injection as tamponade

Exclusion Criteria:

* Patients with history of intraocular surgery, laser therapy or intravitreal injection.
* Patients with significant corneal opacity.
* Patients with ocular diseases as retinal vein occlusion, uveitis and proliferative diabetic retinopathy.
* Patients with preexisting glaucoma or family history of glaucoma.
* Patients with nystagmus.
* Patient with tractional retinal detachment, exudative retinal detachment or intraocular foreign body.
* Patients with anterior chamber abnormalities including posterior synechia, peripheral anterior synechia, hyphaema and iris abnormalities.
* Patients with severe proliferative vitreoretinopathy grade C or more.

Primary outcomes:
measure: Assessement of the changes in anterior chamber angle after vitrectomy with silicone oil injection
timeFrame: postoperative evaluation for 3 months duration (5 visits pre-ppv then one week, one month, three months )
Secondary outcomes:
Other outcomes:
Locations:
city: Minya
country: Egypt
facility: Faculty of medicine ,Minia university
Study officials:
References:
citation: Calik B, Ozturk M, Serdarogullari H, Elcioglu M. Evaluation of anterior segment parameters using pentacam in silicone oil-injected patients after pars plana vitrectomy. Indian J Ophthalmol. 2013 Nov;61(11):621-5. doi: 10.4103/0301-4738.123137.