Clinical trial NCT05654311: Performance of EEG During Emergence Agitation in Nasal Surgery.
Official title: The Relationship Between Emergence Agitation and Electroencephalogram in Young Adults Undergoing Nasal Surgery Under General Anesthesia
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Nasal Surgery
Keywords: general anesthesia
electroencephalogram
emergence agitation
sevoflurane
Lead sponsor: Gangnam Severance Hospital
Sponsor class: OTHER
First posted: 2022-12-16
Enrollment: 55
Sex: ALL
Minimum age (years): 19
Maximum age (years): 55
Standard ages: ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: This study collects subjects from a tertiary university hospital.

Brief summary: The purpose of the study is to evaluate the relationship between perioperative electroencephalogram and emergence agitation in the nasal surgery. Previous studies showed that low frequency band wave activity increased during emergence delirium in pediatric patients. It is still not enough to explain the relationship between emergence agitation and electroencephalogram in adults. Researchers will demonstrate the relationship between parameters related electroencephalogram and emergence agitation in adults undergoing nasal surgery.

Detailed description: Researchers use Sedline to perform perioperative EEG measurements of young adult patients undergoing nasal surgery under general anesthesia with sevoflurane. Emergence agitation occurrence and EEG patterns are observed.

The researchers record the patient's sex, type of surgery, pre-education on emergence agitation, preoperative hospital anxiety and depression scale (HADS), postoperative pain, amount of analgesics administered in the surgery/recovery room, and PACU time. Investigators check the correlation between EEG and perioperative variables. Investigators also compare EEG and perioperative variables for those who were given an explanation of emergence agitation and those who were not.

Eligibility criteria: Inclusion Criteria:

* Adult patients aged 19-55 years who are undergoing nasal surgery under general anesthesia using inhalational agent

Exclusion Criteria:

* CNS disease (ex.dementia, stroke, brain tumor, psychological disorder..)
* unable to communicate
* general anesthesia history within 6 months
* disagree to participate in study

Primary outcomes:
measure: EEG band relative power measured in the frontal lobe
timeFrame: From the cessation of sevoflurane inhalation to the extubation of tracheal tubes
measure: occurrence of emergence agitation
timeFrame: From the cessation of sevoflurane inhalation to transfer to the recovery room
Secondary outcomes:
measure: HADS (Hospital Anxiety and Depression Scale)
timeFrame: 1 day before surgery (after admission)
measure: VAS (Visual Analogue Scale)
timeFrame: during 30 minutes after PACU admission
measure: Effect of preoperative education on emergence agitation
timeFrame: up to 6 months after completion of the study
Other outcomes:
Locations:
city: Seoul
country: Korea, Republic of
facility: Gangnam Severance Hospital Yonsei University College of Medicine
Study officials:
References: