Clinical trial NCT04975828: Correlation Between Micro Vascular Complications and Severity of Coronary Artery Disease in Type 2 DM
Official title: Correlation Between Micro Vascular Complications and Severity of Coronary Artery Disease in Type 2 DM
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Patients With Type 2 DM Who Underwent Coronary Angiography Due to Coronary Artery Disease and Presence of Microvascular Complications in Same Patients
Lead sponsor: Sohag University
Sponsor class: OTHER
First posted: 2021-07-23
Enrollment: 70
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: RETROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: This study enrolled 100 patients known type 2 DM with coronary artery disease and coronary angiography done to diagnosis coronary artery disease then assess microvascular complications in those patients by fundus examination-neurologic examination-albumin creatinine ratio-EGFR. IN STUDY investigator exclude any other cause can lead to microvascular complications example hypertension.

aim of study to early predict coronary artery disease in patient with type 2 DM if microvascular complication presenet by non invasive investigation as stress ECG.

Brief summary: Diabetes is a major cause of morbidity and mortality worldwide and it contributes substantially to healthcare costs. Type 2 Diabetes mellitus is the most common type of diabetes accounting for approximately (90%) of all cases.

Type 2 DM carries a two to six times risk of death from cardiovascular etiologies, such that age adjusted prevalence of white Americans for coronary artery disease (CAD) is double in those with type 2 DM than those without .


Eligibility criteria: Inclusion Criteria:

100 Cases were selected with type II (DM) patients who had been admitted for coronary angiography because of suspected (CAD) to the Catheter lab unit of Sohag University Hospital.

Exclusion Criteria:

1. Type 1 DM.
2. Smoker.
3. Hypertension.
4. Pregnant women.
5. Patient known non diabetic retinal disease non diabetic. nephropathy or neuropathy.
6. History of familial dyslipidemia.

Primary outcomes:
measure: correlation between microvascular complications and severity of coronary disease in type2 DM.
timeFrame: 4 months
Secondary outcomes:
Other outcomes:
Locations:
city: Sohag
country: Egypt
facility: Osama R Elsherief
Study officials:
References:
citation: Ybarra-Munoz J, Jurado-Campos J, Garcia-Gil M, Zabaleta-Del-Olmo E, Mir-Coll T, Zabalegui A, Vidal J, Romeo JH. Cardiovascular disease predicts diabetic peripheral polyneuropathy in subjects with type 2 diabetes: A 10-year prospective study. Eur J Cardiovasc Nurs. 2016 Jun;15(4):248-54. doi: 10.1177/1474515114565215. Epub 2014 Dec 19.
citation: Dal Canto E, Ceriello A, Ryden L, Ferrini M, Hansen TB, Schnell O, Standl E, Beulens JW. Diabetes as a cardiovascular risk factor: An overview of global trends of macro and micro vascular complications. Eur J Prev Cardiol. 2019 Dec;26(2_suppl):25-32. doi: 10.1177/2047487319878371. Epub 2019 Nov 13.
citation: Glovaci D, Fan W, Wong ND. Epidemiology of Diabetes Mellitus and Cardiovascular Disease. Curr Cardiol Rep. 2019 Mar 4;21(4):21. doi: 10.1007/s11886-019-1107-y.