Clinical trial NCT06585332: Handgrip and Respiratory Dysfunction in HD Patients.
Official title: Hand Grip Strength As a Screening Tool for Respiratory Dysfunction in Huntington's Disease
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Huntington Disease
Keywords: Huntington Disease
Respiratory dysfunction
Peak cough flow
Handgrip strength
Screening tool
Lead sponsor: General University Hospital, Prague
Sponsor class: OTHER
First posted: 2024-09-05
Enrollment: 70
Sex: ALL
Minimum age (years): 18
Maximum age (years): 80
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: CASE_ONLY
Time perspective: PROSPECTIVE
Sampling method: NON_PROBABILITY_SAMPLE
Study population: people with confirmed diagnosis of Huntington's disease

Brief summary: Hereditary neurodegenerative diagnosis of Huntington's disease (HD) is associated with a progressive deterioration of the respiratory system function . This fact contributes strongly to the increased risk of aspiration pneumonia as a primary cause of death in people with HD. But regularly objective monitoring of the airway system condition is in common clinical practice almost impossible for high time requirements and the need for specialized expensive devices . This drives the need for a simpler and more cost-effective screening tool. In recent years published studies, working with all ages and genders, show correlation between hand grip strength (HGS) and respiratory parameters. As a second simple screening tool, we chose a short questionnaire called the Index of pulmonary dysfunction.

Detailed description: Goal: To identify a simple method for screening respiratory muscle and cough weakness in Huntington\&#39;s Disease (HD) patients, suitable for clinical practice.

Hypothesis 1: Maximal inspiratory pressure, maximal expiratory pressure, and voluntary peak cough flow will be significantly correlated with maximal hand grip strength in HD patients.

Hypothesis 2: Maximal inspiratory pressure, maximal expiratory pressure, and voluntary peak cough flow will be significantly correlated with the Index of pulmonary dysfunction in HD patients.

Eligibility criteria: Inclusion Criteria:

* Genetic confirmed diagnosis of Huntington's disease

Exclusion Criteria:

* diagnosis of other concomitant neurological diseases;
* a history of cardiovascular or lung disease;
* respiratory symptoms such as cough, phlegm, wheezing, or dyspnea at the time of assessment

Primary outcomes:
measure: Maximal Hand grip strength
timeFrame: Up to 35 weeks (once on a single screening visit)
measure: Voluntary peak cough flow
timeFrame: Up to 35 weeks (once on a single screening visit)
measure: Maximal expiratory pressure, Maximal inspiratory pressure
timeFrame: Up to 35 weeks (once on a single screening visit)
Secondary outcomes:
measure: Index of Pulmonary dysfunction
timeFrame: Up to 35 weeks (once on a single screening visit)
Other outcomes:
Locations:
city: Prague
country: Czechia
facility: General University Hospital
Study officials:
affiliation: General University Hospital
name: Romana Konvalinkova, MS
role: PRINCIPAL_INVESTIGATOR
References:
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