Clinical trial NCT04773028: The Role of Matrix Metalloproteinase 2 and 9 Enzymes in Developing Chronic Thromboembolic Pulmonary Hypertension
Official title: The Role of Matrix Metalloproteinase 2 and 9 Enzymes in Developing Chronic Thromboembolic Pulmonary Hypertension
Study type: OBSERVATIONAL
Overall status: COMPLETED
Conditions: Chronic Thromboembolic Pulmonary Hypertension
Lead sponsor: Kartal Kosuyolu High Speciality Training and Research Hospital
Sponsor class: OTHER_GOV
First posted: 2021-02-26
Enrollment: 48
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: OTHER
Time perspective: PROSPECTIVE
Sampling method: PROBABILITY_SAMPLE
Study population: Study population has chronic thromboembolic pulmonary hypertension and will be performed pulmonary thromboendarterectomy.

Brief summary: Chronic thromboembolic pulmonary hypertension is an occlusive disease in pulmonary artery.Matrix metalloproteinase enzymes play a substantial role of extracellular matrix remodeling. The clot formed in chronic thromboembolic pulmonary hypertension does not melt and turns into a fibrous state, it occludes the pulmonary artery.In this study, investigators aimed to investigate the role of matrix metalloproteinase enzymes in pulmonary arterial wall remodeling in patients with chronic thromboembolic pulmonary hypertension

Detailed description: Chronic thromboembolic pulmonary hypertension is an occlusive disease in pulmonary artery. Only 4% of patients with acute pulmonary embolism develop chronic thromboembolic pulmonary hypertension and acute pulmonary embolism or deep vein thrombosis is reported in the anamnesis of 75% of those with chronic thromboembolic disease. Therefore, the etiology of the disease is not clear. Altought many studies are done, especially the role of inflamation is emhasised underlie the disease.

Matrix metalloproteinase enzymes play a substantial role of extracellular matrix remodeling. The clot formed in chronic thromboembolic pulmonary hypertension does not melt and turns into a fibrous state, it occludes the pulmonary artery.In this study, investigators aimed to investigate the role of matrix metalloproteinase enzymes in pulmonary arterial wall remodeling in patients with chronic thromboembolic pulmonary hypertension.

Matrix metalloprotinase enzymes are known to play a role in atherosclerosis. This research will investigate whether there is atherosclerosis together with inflamattion in the background of chronic thromboembolic hypertension.

Eligibility criteria: Inclusion Criteria:

* Despite 3 months of anticoagulation therapy
* mean pulmonary arterial pressure \> 20 mmHg
* pulmonary vasculary resistance \> 3 wood
* pulmonary capillary wedge pressure \< 15 mmHg
* perfusion defect in ventilation perfusion scintigraphy
* pulmonary angiography or computed tomography angiography showing pulmonary artery occlusive lesions

Exclusion Criteria:

* Patients undergoing pulmonary thromboendarterectomy concomitant coronary bypass, carotid endarterectomy, aortic valve, ascending aorta, mitral valve, tricuspid valve, pulmonary valve surgery
* Patients who have undergone surgical or percutaneous procedures due to atherosclerotic disease

Primary outcomes:
measure: Concentration of Matrix Metalloproteinase 2 and 9 Enzymes
timeFrame: 1 year
Secondary outcomes:
Other outcomes:
Locations:
city: Istanbul
country: Turkey
facility: Kartal Kosuyolu High Speciality Training and Research Hospital
state: Eyalet/Yerleşke
Study officials:
affiliation: kartal kosuyolu hıgh specıalty training and research hospital
name: mehmet yanartas
role: STUDY_DIRECTOR
References: