Clinical trial NCT04830059: The Joint Effect of Air Pollution and Exercise on Cognitive Function
Official title: The Joint Effect of Air Pollution and Exercise on Cognitive Function
Study type: INTERVENTIONAL
Overall status: UNKNOWN
Phase: NA
Conditions: Exercise
Air Pollution
Cognition
Health Promotion
Lead sponsor: Tsinghua University
Sponsor class: OTHER
First posted: 2021-04-02
Enrollment: 93
Sex: ALL
Minimum age (years): 20
Maximum age (years): 30
Standard ages: ADULT
Accepts healthy volunteers: yes
Allocation: RANDOMIZED
Intervention model: PARALLEL
Intervention model description: Double blind randomized controlled trial
Primary purpose: TREATMENT

Brief summary: A double-blind randomized controlled trial design is used in this study. A mixed design of 2 (pollution reduction group vs. no pollution reduction group) × 3 (high intensity intermittent exercise \[HIIT\], moderate intensity of aerobic exercise \[MICT\] and control group \[CONT\]) is used. 93 subjects recruited by advertising will be randomly divided into 6 groups: high intensity exercise group (pollution reduction vs no pollution reduction), moderate intensity aerobic exercise group (pollution reduction vs no pollution reduction) and Stretching group (Control) (pollution reduction vs no pollution reduction).

Detailed description: Environmental intervention program In the pollution reduction groups, the air purification system is used 2 hours before the subjects entered the room to minimize the indoor PM2.5 and PM10.

Exercise intervention program including HIIT, MICT and Stretching (Control) group :

The VO2max of all subjects are measured one week before the experiment. HIIT program: 20 minutes exercise of HIIT (1min of 100% VO2max and 1min of 50% VO2max alternately) and 10 minutes of warm-up and relaxation.

MICT program: 20 minutes exercise of 70-75% VO2max and 10 minutes of warm-up and relaxation.

Stretching control group: 30 minutes of stretching, posture adjustment and rehabilitation courses taught by professional therapists.

Eligibility criteria: Inclusion Criteria:

* No regular exercise in the past six months;
* Healthy people without history of disease;
* Aged between 20 and 30 years old.

Exclusion Criteria:

* Professional athletes;
* Regular exercise in the past six months;
* People who are injured or have a history of disease in the past six months;
* People who have a history of taking medicine in the past six months.

Primary outcomes:
measure: Change of cognitive function
timeFrame: Before and after acute exercise (about 30 minutes).
measure: Change of biomarkers
timeFrame: Before and after acute exercise (about 30 minutes).
measure: Change of oxyhemoglobin
timeFrame: Before and after acute exercise (about 30 minutes).
measure: Change of transcriptions
timeFrame: Before and after acute exercise (about 30 minutes).
measure: Change of metabonomics
timeFrame: Before and after acute exercise (about 30 minutes).
measure: Change of cerebral blood flow
timeFrame: Before and after acute exercise (about 30 minutes).
Secondary outcomes:
measure: Change of cognitive function
timeFrame: Three months (from baseline to the third month)
measure: Change of aerobic capacity
timeFrame: Three months (from baseline to the third month)
measure: Change of cerebral blood flow
timeFrame: Three months (from baseline to the third month)
measure: Change of biomarkers
timeFrame: Three months (from baseline to the third month)
measure: Change of oxyhemoglobin
timeFrame: Three months (from baseline to the third month)
measure: Change of metabonomics
timeFrame: Three months (from baseline to the third month)
measure: Change of transcriptions
timeFrame: Three months (from baseline to the third month)
Other outcomes:
Locations:
city: Beijing
country: China
facility: Tsinghua University
state: Beijing
Study officials:
affiliation: Wanke School of public health, Tsinghua University
name: Qian Di, Sc.D.
role: STUDY_DIRECTOR
affiliation: Department of physical education, Tsinghua University
name: Xindong Ma, PhD
role: STUDY_CHAIR
References: