Clinical trial NCT07027397: One Year of Velocity-based Resistance Training in Older People Living in Nursing Homes
Official title: One Year of Velocity-based Resistance Training in Older People Living in Nursing Homes: Effects on Skeletal Muscle Mass, Muscle Function, and Physical and Cognitive Function
Study type: INTERVENTIONAL
Overall status: ACTIVE_NOT_RECRUITING
Phase: NA
Conditions: Aging
Muscle Mass and Strength
Muscle Power
Frailty Syndrome
Cognitive Function
Lead sponsor: University of Castilla-La Mancha
Sponsor class: OTHER
First posted: 2025-06-18
Enrollment: 15
Sex: ALL
Minimum age (years): 65
Standard ages: OLDER_ADULT
Accepts healthy volunteers: yes
Allocation: NA
Intervention model: SINGLE_GROUP
Primary purpose: TREATMENT

Brief summary: This study is an exercise intervention assessing the efficacy of a velocity-based resistance training (VBRT) in institutionalized older adults.

The aim of this study is to assess the effects of one year of velocity-based resistance training on skeletal muscle mass, muscle function, and physical and cognitive function in older adults living in nursing homes.

Detailed description: Evidence supports the fact that resistance exercise training is effective in improving old adult's health and palliate age-related disorders. New approaches in resistance training are emerging to maximize monitoring control, providing more tailored and potentially more effective exercise interventions. Among them, the velocity-based resistance training (VBRT) is being established in healthy populations or populations with pathologies. However, the effects of long-term VBRT in institutionalized older adults are still unknown.

Thus, the aim of this study is to assess the effects of one year of velocity-based resistance training on skeletal muscle mass, muscle function, and physical and cognitive function in older adults living in nursing homes.

Eligibility criteria: Inclusion Criteria:

* Older people living permanently in nursing home.
* Age ≥ 65 years old.
* Are able to walk with/without assistance.
* Have ability to communicate with the research team.

Exclusion Criteria:

* Terminal illness.
* Any illness not controled (cardiac, pulmonary, etc).
* If there is a risk of bone fracture according to medical staff.

Primary outcomes:
measure: Change in muscle power
timeFrame: T0 (baseline); T1 (post 6 weeks); T2 (post 12 weeks); T3 (post 23 weeks) and T4 (post 39 weeks).
measure: Changes in neuromuscular performance of lower-body
timeFrame: T0 (baseline); T1 (post 6 weeks); T2 (post 12 weeks); T3 (post 23 weeks) and T4 (post 39 weeks).
Secondary outcomes:
measure: Change in physical function based on the Short Physical Performance Battery score
timeFrame: T0 (baseline); T1 (post 6 weeks); T2 (post 12 weeks); T3 (post 23 weeks) and T4 (post 39 weeks).
measure: Change in frailty (score) using Fried's Frailty Criteria and Frailty Trait Scale - Short Form
timeFrame: T0 (baseline); T1 (post 6 weeks); T2 (post 12 weeks); T3 (post 23 weeks) and T4 (post 39 weeks).
measure: Change in muscle mass using ultrasonography.
timeFrame: T0 (baseline); T1 (post 6 weeks); T2 (post 12 weeks); T3 (post 23 weeks) and T4 (post 39 weeks).
measure: Change in disability using Barthel and Lawton scales
timeFrame: T0 (baseline); T1 (post 6 weeks); T2 (post 12 weeks); T3 (post 23 weeks) and T4 (post 39 weeks).
measure: Change in cognitive function using Mini-Mental State Examination
timeFrame: T0 (baseline); T1 (post 6 weeks); T2 (post 12 weeks); T3 (post 23 weeks) and T4 (post 39 weeks).
measure: Change in handgrip strength
timeFrame: T0 (baseline); T1 (post 6 weeks); T2 (post 12 weeks); T3 (post 23 weeks) and T4 (post 39 weeks).
Other outcomes:
Locations:
city: Toledo
country: Spain
facility: University of Castilla-La Mancha
Study officials:
affiliation: University of Castilla-La Mancha
name: Julian Alcazar, PhD
role: PRINCIPAL_INVESTIGATOR
References: