Clinical trial NCT06987461: Study of the Use of Non-invasive Ventilation in Bronchial Dilatation Disease
Official title: Study of the Use of Non-invasive Ventilation in Bronchial Dilatation Disease (BRONCHINIV)
Study type: OBSERVATIONAL
Overall status: RECRUITING
Conditions: Bronchial Dilatation Disease
Bronchectasie
Keywords: bronchial dilatation disease
Non-invasive ventilation
efficiency
Lead sponsor: Centre Hospitalier Intercommunal Creteil
Sponsor class: OTHER
First posted: 2025-05-23
Enrollment: 70
Sex: ALL
Minimum age (years): 18
Standard ages: ADULT
OLDER_ADULT
Accepts healthy volunteers: no
Observational model: COHORT
Time perspective: OTHER
Sampling method: NON_PROBABILITY_SAMPLE
Study population: Population currently being treated for bronchial dilatation treated with long-term NIV

Brief summary: This is a medical record data collection study. The goal of this non-interventional and retrospective study is to describe the characteristics of the population currently being monitored for bronchial dilatation who have been treated with long-term NIV. This is a study based on data from medical records.

The assessment criteria will be :

* Epidemiological characteristics of the population with bronchial dilatation on long-term NIV
* Reasons for initiation of NIV
* NIV adjustment methods

Detailed description: Non-invasive ventilation is a treatment sometimes used for severe severe bronchial dilatation, but to date there are no studies its efficacy.

The expected results in this context are :

* a description of the characteristics of patients with severe bronchial on non-invasive ventilation (NIV)
* a better understanding, during NIV management, of the settings used, the tolerance and effectiveness of NIV in reducing exacerbations, hospital admissions and patient mortality.
* move towards better patient management

Data will be extracted from patient medical records and the PMSI.

Eligibility criteria: Inclusion Criteria:

* Patients over 18 years
* Predominant diagnosis of bronchiectatic disease, excluding cystic fibrosis, confirmed by computed tomography
* Introduction of long-term NIV at a given point in the patient's care

Exclusion Criteria:

* Patient's opposition to participating in this study
* Cystic fibrosis
* Predominant diagnosis of COPD or asthma, traction bronchiectasis, bronchiectasis resulting from focal endobronchial lesion, sarcoidosis or active allergic bronchopulmonary aspergillosis.

Primary outcomes:
measure: epidemiological characteristics of the population with bronchial dilation under long-term NIV
timeFrame: Through study completion, an average of 1 year
measure: Reasons for placing under NIV
timeFrame: Through study completion, an average of 1 year
measure: Non-invasive ventilation adjustment modalities
timeFrame: Through study completion, an average of 1 year
Secondary outcomes:
measure: Number of acute exacerbations (according to international recommendations) after initiation of NIV
timeFrame: Through study completion, an average of 1 year
measure: Stabilization of respiratory functional tests evolution of FEV1 (%, slope) of PaCO2
timeFrame: Through study completion, an average of 1 year
Other outcomes:
Locations:
city: Créteil
country: France
facility: Centre Hospitalier Intercommunal de Créteil
city: Créteil
country: France
facility: Centre Hospitalier Universitaire Henri Mondor
city: Dijon
country: France
facility: Centre Hospitalier Universitaire de Dijon
city: Rennes
country: France
facility: Centre Hospitalier Universitaire de Rennes
city: Toulouse
country: France
facility: Centre Hospitalier Universitaire Toulouse
Study officials:
References: